Phosphine oxides as efficient neutral coordinate-organocatalysts for stereoselective allylation of N-acylhydrazones.
Phosphine oxides were found to be efficient neutral coordinate-organocatalysts (NCOs) for the allylation of N-acylhydrazones. Among the phosphine oxides tested, a three carbon-tethered bisphosphine oxide (dppp dioxide) was found to be the most effective, and in the presence of dppp dioxide, less reactive aromatic and [small alpha],[small beta]-unsaturated N-acylhydrazones underwent allylation as well as diastereoselective crotylation. Furthermore, a polymer-supported phosphine oxide was also developed as an effective immobilized NCO.
Ogawa
Chikako
C
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Konishi
Hideyuki
H
Sugiura
Masaharu
M
Kobayashi
Shū
S