[Nasal sinus carcinoma after wood dust exposure. Morphological spectrum of 100 cases].
Sinonasal carcinomas are usually of the squamous cell or transitional cell type. Adenocarcinomas of the inner nose and the paranasal sinus correlate with exposure to wood dust. However, this is only true for adenocarcinomas of the intestinal type and not for salivary gland carcinomas or polymorphous low-grade adenocarcinomas. Of 160 cases with a history of wood dust exposure and malignant tumors of the inner nose, 134 were sinonasal adenocarcinomas of the intestinal type (SNAIT). In addition, there were 24 other carcinomas as well as 1 malignant melanoma and 1 malignant synovial tumor. The SNAIT showed various subtypes with great morphological similarities to colorectal adenocarcinomas (papillary tubular cylinder cell: 72.4%; alveolar goblet cell: 5.2%; signet ring cell: 3.7%; transitional type: 18.7%). Highly differentiated adenocarcinomas (G1) and mucinous adenocarcinomas were relatively frequent: they accounted for 23.1% and 29.1% of the 134 SNAIT, respectively. Apart from wood dust, wood additives are discussed as a carcinogenic factor. With the development of SNAIT, a metaplasia-dysplasia-carcinoma in situ sequence is probable. If the clinical course shows few symptoms, the first manifestation of such a tumor often occurs in an advanced stage.
Donhuijsen
K
K
Institut für Pathologie, Klinikum Braunschweig. k.donhuijsen@klinikum-braunschweig.de
Hattenberger
S
S
Schroeder
H G
HG
D000230:Adenocarcinoma / Q000145:classification / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000209:etiology / Q000473:pathology*; D004391:Dust; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D009669:Nose Neoplasms / Q000145:classification / Q000209:etiology* / Q000473:pathology*; D010255:Paranasal Sinus Neoplasms / Q000145:classification / Q000209:etiology* / Q000473:pathology*; D014934:Wood
D004391:Dust