title: Developmental screening and detection of developmental delays in infants and toddlers with fragile X syndrome.
abstract: Three developmental screening tests (the Denver-II, Battelle Developmental Inventory Screening Test, and Early Language Milestone Scale-2) were administered to 18 infants and toddlers (13 boys and 5 girls) with confirmed diagnoses of fragile X syndrome as part of a comprehensive developmental assessment at 9, 12, and 18 months of age. The Denver-II identified delays for 10 of 11 boys at 9 months of age and the Denver-II and the Early Language Milestone Scale-2 identified delays in 100% of the boys at 12 and 18 months. The Battelle Developmental Inventory Screening Test identified delays in 75% of the children at 12 and 18 months. When compared with more comprehensive developmental tests (Mullen Scales of Early Learning and Receptive-Expressive Emergent Language Scale-2), the screening tests concurred at least 76% of the time at the 12- and 18-month assessments. These results indicate that developmental delays could be detected in most children with fragile X syndrome through routine developmental screening by the age of 9 to 12 months.
authors.affiliation: FPG Child Development Institute, University of North Carolina at Chapel Hill, 27599-8180, USA. penny_mirrett@unc.edu
authors.forename: Penny L
authors.initials: PL
authors.lastname: Mirrett
authors.forename: Donald B
authors.initials: DB
authors.lastname: Bailey
authors.forename: Jane E
authors.initials: JE
authors.lastname: Roberts
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Hatton
mesh_terms: D002658:Developmental Disabilities / Q000175:diagnosis* / Q000628:therapy; D042241:Early Diagnosis; D018479:Early Intervention, Educational; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D007223:Infant; D007805:Language Development Disorders / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008403:Mass Screening; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011379:Prognosis