Hydrogels based on the chemically crosslinked polyacrylic acid: biopharmaceutical characterization.
This study is an attempt of biopharmaceutical characterization of hydrogels based on crosslinked polyacrylic acid (PAA). Macrodiisocyanates (MDIC) or oligomethanediisocyanate (DO) were used as crosslinking agents. The drug release rate from such hydrogels is determined by the density of the net and is lowered by a decrease in the PAA : MDIC mass ratio. The increase of the drug concentration in the matrix improved the release process. The drug release from the hydrogels was found to be pH dependent.
Dimitrov
Milen
M
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria.
Lambov
Nikoali
N
Shenkov
Stoicho
S
Dosseva
Veneta
V
Baranovski
Valdimir Y
VY
D000082:Acetaminophen / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry*; D001702:Biopharmaceutics; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D017953:Isocyanates / Q000737:chemistry; D015394:Molecular Structure; D008970:Molecular Weight; D009538:Nicotine / Q000737:chemistry; D013678:Technology, Pharmaceutical
D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D020100:Hydrogels; D017953:Isocyanates; D000082:Acetaminophen; C006903:carbopol 940; D009538:Nicotine