Cancer in US Air Force veterans of the Vietnam War.
Cancer incidence and mortality were summarized in Air Force veterans of the Vietnam War. The index subjects were Operation Ranch Hand veterans who sprayed 2,3,7,8 tetrachlorodibenzo-p-dioxin (dioxin)-contaminated herbicides in Vietnam. Comparisons served in Southeast Asia during the same period but did not spray herbicides. We assessed cancer incidence and mortality using national rates and contrasted cancer risk in each of three Ranch Hand dioxin exposure categories relative to comparisons. The incidence of melanoma and prostate cancer was increased among white Ranch Hand veterans relative to national rates. Among veterans who spent at most 2 years in Southeast Asia, the risk of cancer at any site, of prostate cancer and of melanoma was increased in the highest dioxin exposure category. These results appear consistent with an association between cancer and dioxin exposure.
Akhtar
Fatema Z
FZ
Spec-Pro, Inc, San Antonio, TX, USA.
Garabrant
David H
DH
Ketchum
Norma S
NS
Michalek
Joel E
JE
D000328:Adult; D000337:Aerospace Medicine; D000368:Aged; D016022:Case-Control Studies; D003678:Defoliants, Chemical / Q000009:adverse effects*; D004147:Dioxins / Q000009:adverse effects* / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000453:epidemiology; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects*; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000453:epidemiology; D012044:Regression Analysis; D012306:Risk; D014481:United States / Q000453:epidemiology; D014728:Veterans / Q000706:statistics & numerical data; D014744:Vietnam; D014857:Warfare
D003678:Defoliants, Chemical; D004147:Dioxins