Risk factors for retinopathy of prematurity requiring photocoagulation.
OBJECTIVE
To analyze risk factors other than birthweight (BW) and gestational age for retinopathy of prematurity (ROP) requiring photocoagulation in infants (BW<1500 g).


METHODS
We divided 45 eyes with ROP into three groups (A, without photocoagulation; B, with <6 clock hours photocoagulation; C, with > or =6 clock hours photocoagulation) and analyzed maternal and neonatal factors by multiple logistic regression.


RESULTS
Among 13 factors, the number of days of infection, defined as C-reactive protein (CRP) greater than 1.0 mg/dl, was a significant risk between groups A and B+C [Odds ratio (OR), 1.549; 95% Confidence interval (CI), 1.008-2.381; P=0.046]. Among six after-birth factors, the number of days of infection (OR, 1.404; 95% CI, 1.023-1.928; P=0.036) was significant between groups A and B+C, and the number of blood transfusions (OR, 4.959; 95% CI, 1.002-24.54; P=0.050) and use of rescue surfactant (OR, 413.9; 95% CI, 1.163-147306; P=0.044) were significant between groups B and C.


CONCLUSIONS
CRP should be routinely monitored while observing the progress of preterm infants. The probability of requiring photocoagulation increased in infants who received a blood transfusion or rescue surfactant.
Ikeda
Hiromi
H
Department of Ophthalmology, Hyogo Prefectural Amagasaki Hospital, Hyogo, Japan. mikeda@osaka-u.ac.jp
Kuriyama
Shoji
S
D001724:Birth Weight; D001803:Blood Transfusion; D002097:C-Reactive Protein / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007239:Infections / Q000150:complications; D017075:Laser Coagulation; D012178:Retinopathy of Prematurity / Q000097:blood / Q000209:etiology / Q000601:surgery*; D012189:Retrospective Studies; D012307:Risk Factors
D002097:C-Reactive Protein