title: Chronic psychological effects of exposure to mercury vapour among chlorine-alkali plant workers.
abstract: BACKGROUND
  Quantitative assessment of nervous system function is essential in characterising the nature and extent of impairment in individuals experiencing symptoms following work-place mercury vapour exposure.
  
  
  OBJECTIVE
  The purpose of this study was the application of standardised tests of behavioural, psychomotor and memory function to understand the neuropsychological effects of mercury in occupationally exposed chlorine-alkali plant workers.
  
  
  METHODS
  The study comprised 45 workers at a chlorine-alkali plant with the mean age of 39.36 +/- 5.94 years, who had been exposed to daily inhalation of mercury vapour over long-term employment of 16.06 +/- 4.29 years. The cumulative mercury index was 155.32 +/- 95.02 micrograms/g creatinine, the mean of urinary mercury concentrations on the first day of the study was 119.50 +/- 157.24 micrograms/g creatinine, and the mean of urinary mercury concentrations 120 days after cessation of exposure was 21.70 +/- 26.07 micrograms/g creatinine. The analysis included tests of behavioural, psychomotor and memory function. The behavioural test battery consisted of: Environmental Worry Scale (EWS), Minnesota Modified Personal Inventory (MMPI-2), Purdue standard 25 minute test, and adapted, 10 minutes test, Bender's Visual-Motor Gestalt test (BGT), and Eysenck Personality Inventory (EPQ). The data were compared to a control group of 32 not directly exposed workers.
  
  
  RESULTS
  In the mercury vapour exposed workers with relatively high level exposure to inorganic mercury vapour (TWA/TLV = 0.12 mg/m3/0.025 mg/m3) we identified somatic depression-hypochondria symptoms with higher scores for scales: hysteria (P < 0.001), schizoid and psycho-asthenia (MMPI-2). The mercury-exposed workers had introvert behaviour (EPQ, MMPI-2). The cognitive disturbances in mercury-exposed workers were identified as: concentration difficulty, psychomotor, perceptual and motor coordination disturbances, and brain effects. We identified fine tremor of the hands in 34 out of 45 mercury-exposed workers (BGT).
  
  
  CONCLUSIONS
  The results point to a relationship between the duration of mercury exposure and the long-term, probably irreversible, psychological disturbances.
authors.affiliation: Division of Occupational Medicine, Tuzla University School of Medicine, Tuzla, Bosnia and Herzegovina. pranicnurka@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Pranjić
authors.forename: O
authors.initials: O
authors.lastname: Sinanović
authors.forename: R
authors.initials: R
authors.lastname: Jakubović
mesh_terms: D000328:Adult; D000468:Alkalies; D002617:Chemical Industry; D017606:Chlorine Compounds; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008630:Mercury Poisoning / Q000523:psychology*; D008875:Middle Aged; D009784:Occupational Diseases / Q000523:psychology*; D016273:Occupational Exposure / Q000009:adverse effects*; D010556:Personality Tests; D014835:Volatilization
chemical_list: D000468:Alkalies; D017606:Chlorine Compounds