title: Fetal hydrops, associated with maternal propylthiouracil exposure, reversed by intrauterine therapy.
abstract: Thyroid hormone is essential for fetal neurological development. Among other etiologies, fetal hypothyroidism may be caused by maternal exposure to antithyroid drugs (ATDs). The most common presentation of fetal hypothyroidism is fetal goiter, which can cause dystocia, in addition to airway obstruction in the neonate. Intra-amniotic treatment with levothyroxine normalizes fetal thyroid status and reduces goiter size. We present a case of fetal hypothyroidism diagnosed in a patient who was treated with propylthiouracil (PTU) for Grave's disease. The fetus had marked hydrops fetalis and a large goiter. In addition, anal stenosis, vesicovaginal fistula, bilateral pyelectasia and polydactyly were diagnosed in the neonate. Intra-amniotic treatment with levothyroxine resulted in a regression of the hydrops and a reduction in the goiter size. A euthyroid, non-edematous, non-goitrous neonate was delivered. At the age of 27 months the child's psychomotor development was normal. The present case indicates that hydrops fetalis may be an unusual manifestation of fetal hypothyroidism, caused by intrauterine exposure to maternal antithyroid drugs (ATDs), and that it may be resolved by treatment with intra-amniotic levothyroxine.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah Medical Center, Ein-Kerem, The Hebrew University Medical School, Jerusalem, Israel.
authors.forename: N
authors.initials: N
authors.lastname: Yanai
authors.forename: D
authors.initials: D
authors.lastname: Shveiky
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D006042:Goiter / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D015160:Hydrops Fetalis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D007037:Hypothyroidism / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011295:Prenatal Care / Q000379:methods*; D011441:Propylthiouracil / Q000009:adverse effects*; D016216:Ultrasonography, Prenatal
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil