title: [Effectiveness of anti-emetics for the prophylaxis of cisplatin-induced delayed emesis: a systematic review].
abstract: We performed a systematic review of the effectiveness of anti-emetics for prophylaxis of cisplatin-induced delayed emesis using meta-analysis. We selected 12 reports of randomized controlled trials from MEDLINE (1966-2003. 4) and The Cochrane Library Issue 1, 2003. Nine of these reports were evaluated as high quality and the others as low quality according to the evaluation criteria of Jadad et al., and only the high-quality reports were subjected to meta-analysis. The statistical results obtained from all 12 reports were also compared with those obtained from the 9 reports of high quality. Corticosteroids significantly reduced the occurrence of delayed emesis. Metoclopramide tended to reduce the occurrence of delayed emesis, although not to a significant extent. In contrast, 5-HT3 receptor antagonists did not show a significant prophylactic effect on delayed emesis. Combination treatments using corticosteroids with metoclopramide or 5-HT3 receptor antagonists did not show significant additional benefits over corticosteroids alone. In conclusion, treatment with corticosteroids without additional metoclopramide or 5-HT3 receptor antagonists appears to be preferable for the prevention of delayed emesis induced by cisplatin.
authors.affiliation: Graduate School, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose City, Tokyo 204-8588, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kubota
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mihara
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Ishii
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohno
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogata
authors.forename: Mizue
authors.initials: M
authors.lastname: Makimura
authors.forename: Norikazu
authors.initials: N
authors.lastname: Kikuchi
authors.forename: Taeko
authors.initials: T
authors.lastname: Kitano
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D016239:MEDLINE; D008787:Metoclopramide / Q000627:therapeutic use; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000305:Adrenal Cortex Hormones; D000932:Antiemetics; D000970:Antineoplastic Agents; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists; D008787:Metoclopramide; D002945:Cisplatin