title: Effects of intranasal estradiol treatment on serum lipoprotein(a) and lipids in hysterectomized women.
abstract: The aim of the present study was to evaluate the effects of intranasal estradiol on lipid metabolism and lipoprotein(a) [Lp(a)] levels. A prospective comparative study was designed: 49 hysterectomized, healthy postmenopausal women received intranasal 17beta-estradiol (E2; 300 microg/day). Blood samples were collected at baseline and at the end of the 3 and 6 months of therapy. After 6 months, the serum levels of total cholesterol, LDL-cholesterol and triglycerides did not show any significant change with intranasal 17beta-E2 therapy. HDL-cholesterol levels at 3 and 6 months of treatment were significantly increased compared with baseline levels (p = 0.031, p = 0.000, respectively). There was a significant change in serum Lp(a) levels at the 6th month (p = 0.003) but not at the 3rd month (p = 0.183) compared with the baseline levels. Further studies are needed to detect whether these changes are significant and permanent or not.
authors.affiliation: Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University School of Medicine, Kahramanmaras, Turkey. hakankiran01@yahoo.com
authors.forename: Hakan
authors.initials: H
authors.lastname: Kiran
authors.forename: Gurkan
authors.initials: G
authors.lastname: Kiran
authors.forename: Hasan C
authors.initials: HC
authors.lastname: Ekerbicer
authors.forename: Metin
authors.initials: M
authors.lastname: Kilinc
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D004958:Estradiol / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood / Q000187:drug effects*; D008875:Middle Aged; D017698:Postmenopause; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D017270:Lipoprotein(a); D014280:Triglycerides; D004958:Estradiol; D002784:Cholesterol