[Research of cross-linking reagent for producing hyaluronic acid derivative].
OBJECTIVE
To review the recent advances of cross-linking reagent for producing hyaluronic acid (HA) derivative so as to provide more advice for the development of HA reagent.


METHODS
Recent original articles related to the species, characteristic, cross-linking methodology and mechanism of the cross-linking reagent to producing HA derivative were summarized and systematically analyzed.


RESULTS
The derivatives after special kinds of reagents modification would remain their own good biocompatibility and change their original rheololgical characterization and obtain relative long organism residence time.


CONCLUSIONS
Development of hyaluronic derivatives may widen their medical application.
Chen
Jing-hua
JH
Shanghai Qisheng Biomaterial Institute, Shanghai, P. R. China 201106.
Lin
Cong
C
Gu
Qi-sheng
QS
D001672:Biocompatible Materials / Q000627:therapeutic use; D003432:Cross-Linking Reagents / Q000737:chemistry; D020723:Glucuronic Acid; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000145:classification
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020723:Glucuronic Acid; D006820:Hyaluronic Acid