MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment.
Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.
Bleiber
Gabriela
G
Institute of Microbiology and Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland.
May
Margaret
M
Suarez
Carlos
C
Martinez
Raquel
R
Marzolini
Catia
C
Egger
Matthias
M
Telenti
Amalio
A
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000503:physiopathology; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015331:Cohort Studies; D017931:DNA Primers; D018450:Disease Progression; D019450:Genes, MDR / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000503:physiopathology; D015497:HIV-1; D006801:Humans; D011110:Polymorphism, Genetic
D017931:DNA Primers