Effects of starches on the mechanical properties of paracetamol tablet formulations. II. Sorghum and plantain starches as disintegrants.
This study evaluates the disintegrant properties--tablet disintegration time (DT) and crushing strength--friability/disintegration time (CSFR/DT) ratio of a paracetamol tablet formulation prepared with sorghum and plantain starches in comparison with corn starch BP. The effects of disintegrant concentration, relative density of tablets and the mode of disintegrants addition were studied. The study revealed that the rank order of effectiveness of the starches as disintegrants was corn > plantain > sorghum. The mode of addition of disintegrants, disintegrant concentration and relative density had a significant impact on the disintegrant properties. The tested starches, namely, sorghum and plantain, showed promising results.
Alebiowu
Gbenga
G
Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. galebiowu@yahoo.co.uk
Itiola
Oludele Adelanwa
OA
D000082:Acetaminophen / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005069:Evaluation Studies as Topic; D005079:Excipients; D006245:Hardness Tests; D009549:Nigeria; D010943:Plantago / Q000737:chemistry; D045868:Sorghum / Q000737:chemistry; D013213:Starch / Q000737:chemistry*; D013607:Tablets
D005079:Excipients; D013607:Tablets; D000082:Acetaminophen; D013213:Starch