title: Phosphine oxides as efficient neutral coordinate-organocatalysts for stereoselective allylation of N-acylhydrazones.
abstract: Phosphine oxides were found to be efficient neutral coordinate-organocatalysts (NCOs) for the allylation of N-acylhydrazones. Among the phosphine oxides tested, a three carbon-tethered bisphosphine oxide (dppp dioxide) was found to be the most effective, and in the presence of dppp dioxide, less reactive aromatic and [small alpha],[small beta]-unsaturated N-acylhydrazones underwent allylation as well as diastereoselective crotylation. Furthermore, a polymer-supported phosphine oxide was also developed as an effective immobilized NCO.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Ogawa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sugiura
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi