title: Fatal arrhythmia following intraoperative continuous hyperthermic peritoneal perfusion chemotherapy.
abstract: Continuous hyperthermic peritoneal perfusion chemotherapy (CHPPC) offers a safe alternative to manage peritoneal tumor seeding in advanced cancer patients. A 65-year-old male underwent exploratory laparotomy for advanced gastric cancer with intraabdominal carcinomatosis and massive ascites. Life-threatening dysrrhythmia of ventricular rhythm with a rate of 120 beats/min developed during the performance of intraoperative CHPPC following eradication of the main tumor. With timely cardiopulmonary resuscitation, appropriate fluid replacement, correction of electrolyte imbalance, and cooling of body temperature, the patient regained effective cardiopulmonary circulation without sequela.
authors.affiliation: Department of Anesthesiology, Kaohsiung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taiwan, R.O.C.
authors.forename: Nien-Chun
authors.initials: NC
authors.lastname: Chung
authors.forename: Yen-Chin
authors.initials: YC
authors.lastname: Liu
authors.forename: Xuan-De
authors.initials: XD
authors.lastname: Ye
authors.forename: Ying-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Mei-Ching
authors.initials: MC
authors.lastname: Kuo
authors.forename: Kang
authors.initials: K
authors.lastname: Liu
mesh_terms: D000008:Abdominal Neoplasms / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002277:Carcinoma / Q000601:surgery; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007430:Intraoperative Care / Q000009:adverse effects*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D017180:Tachycardia, Ventricular / Q000209:etiology*
chemical_list: D016685:Mitomycin; D002945:Cisplatin