Oxidative stress in the pathogenesis of asthma.
Asthma affects 5% to 10% of the population of the United States. In asthmatics, oxidative stress occurs not only as a result of inflammation but also from environmental exposure to air pollution. The specific localization of antioxidants in the lung and the adaptive changes during asthma underscore the importance of oxidative stress, and therapeutic interventions that decrease exposure to environmental reactive oxygen species or augment endogenous antioxidant defenses might be beneficial as adjunctive therapies in asthmatic patients.
Bowler
Russell P
RP
National Jewish Medical and Research Center, K736a, 1400 Jackson Street, Denver, CO, 80206, USA. BowlerR@njc.org
D000975:Antioxidants / Q000378:metabolism; D001249:Asthma / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D014481:United States / Q000453:epidemiology
D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species