Emergence of nonencapsulated and encapsulated non-b-type invasive Haemophilus influenzae isolates in Portugal (1989-2001).
Phenotypes and genetic relatedness of invasive Haemophilus influenzae strains were evaluated from 1989 through 2001. Among 119 isolates, multidrug resistance decreased (from 50 to 0%), the level of H. influenzae serotype b (Hib) strains declined (from 81 to 16%), the level of noncapsulated strains rose (from 19 to 80%), and the first invasive H. influenzae serotype f strain was described. This study documents changes in invasive H. influenzae infections in Portugal, i.e., the emergence of non-type-b strains that are genetically diverse and unrelated to Hib.
Bajanca
Paula
P
Antibiotic Resistance Unit, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal. paula.lavado@insa.min-saude.pt
Caniça
Manuela
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D018432:Drug Resistance, Multiple / Q000235:genetics; D006192:Haemophilus Infections / Q000175:diagnosis*; D019741:Haemophilus influenzae type b / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D010802:Phylogeny; D011174:Portugal
D000900:Anti-Bacterial Agents