Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence.
The hydrozirconation of alkynes with zirconocene hydrochloride and the dimethylzinc-mediated addition of alkenylzirconocenes to diphenylphosphinoyl imines can be greatly accelerated with microwave irradiation, resulting in a convenient and rapid one-pot process for the preparation of synthetically useful allylic amines.
Wipf
Peter
P
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. pwipf@pitt.edu
Janjic
Jelena
J
Stephenson
Corey R J
CR
D000498:Allyl Compounds / Q000138:chemical synthesis*; D000588:Amines / Q000138:chemical synthesis*; D006859:Hydrogen / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D017640:Silicates / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
D000498:Allyl Compounds; D000588:Amines; D007097:Imines; D017640:Silicates; C003784:zircon; D006859:Hydrogen; D015040:Zirconium