Treatment of patients with respiratory reactions to aspirin and nonsteroidal anti-inflammatory drugs.
Aspirin exacerbated respiratory disease (AERD) is an adult onset condition manifested as asthma, rhinosinusitis/nasal polyps, and sensitivity to aspirin and other cyclooxygenase-1 (Cox-1)-inhibitor nonsteroidal anti-inflammatory drugs (NSAIDs). There is no cross-sensitivity to highly selective Cox-2 inhibitors.
Simon
Ronald A
RA
Division of Allergy, Asthma and Immunology, Scripps Clinic, 10666 North Torrey Pines Road, 205W, La Jolla, CA 92037, USA. rsimon@scrippsclinic.com
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D003429:Cross Reactions / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects; D019468:Disease Management; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000628:therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D001241:Aspirin