Markedly prolonged jaundice from simultaneous infection with hepatitis E virus and leptospira.
We treated a patient simultaneously infected with hepatitis E virus and Leptospira interrogans, both acquired in China. Severe hyperbilirubinemia required nearly 200 days to resolve, transminase elevation showed a fluctuating course, and liver biopsy specimens showed fibrosis unusual for hepatitis E. Leptospirosis appeared to have altered the course of hepatitis E virus infection in this patient, even though infection with Leptospira was cleared with antibiotics by 50 days after the onset of the hepatitis symptoms.
Suzuki
Asuka
A
Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Kumashiro
Ryukichi
R
Shirachi
Miki
M
Kuroki
Mina
M
Suzuki
Hiroshi
H
Tanikawa
Kyuichi
K
Sata
Michio
M
D016751:Hepatitis E / Q000150:complications* / Q000473:pathology; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D007921:Leptospira interrogans; D007922:Leptospirosis / Q000150:complications*; D008297:Male; D008875:Middle Aged