Reactivation of the bacille Calmette-Guérin scar following immune reconstitution during treatment of infant acute lymphoblastic leukemia.
The authors describe an infant presenting at 2 weeks of age with congenital acute lymphoblastic leukemia who had previously received routine bacille Calmette-Guérin (BCG) vaccination at birth. The risk of BCG dissemination in immunocompromised infants is discussed and the use of antimycobacterial prophylaxis in such cases considered.
Swinson
Sophie
S
Department of Pediatrics, University of Oxford, Oxford, United Kingdom.
Hall
Georgina
G
Pollard
Andrew J
AJ
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001500:BCG Vaccine / Q000008:administration & dosage*; D002921:Cicatrix / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007231:Infant, Newborn; D009163:Mycobacterium bovis / Q000502:physiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital / Q000188:drug therapy*; D014376:Tuberculosis / Q000517:prevention & control; D014611:Vaccination; D014775:Virus Activation / Q000187:drug effects*
D001500:BCG Vaccine