title: Total synthesis of (+)-tanikolide via oxidative lactonization.
abstract: (+)-Tanikolide has been synthesized in eight linear steps with a 31% overall yield. The key step in the synthesis utilizes a recently developed tandem oxidative cleavage-lactonization of a precursor alkenol to deliver the lactone moiety.
authors.affiliation: Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA. borhan@cem.msu.edu
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Schomaker
authors.forename: Babak
authors.initials: B
authors.lastname: Borhan
mesh_terms: D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D007783:Lactones; C400156:tanikolide