Synthesis and anti-inflammatory activity of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidine-5-yl]-acetic acid derivatives.
Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium.
Bahekar
Sushilkumar S
SS
Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431 004 MS, India. sushil@chemist.com
Shinde
Devanand B
DB
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D005260:Female; D008297:Male; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use*; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines