The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of esophageal strictures related to caustic injury.
BACKGROUND
To assess the effects of halofuginone, a specific inhibitor of synthesis of collagen type 1, which is the major constituent of fibrosis, on esophageal stricture formation due to caustic ingestion.


METHODS
Sixty rats were divided into four equal groups: control group; sham laparotomy group; caustic injury without treatment group; caustic injury with halofuginone treatment group. Caustic injuries were done by 50% sodium hydroxide. Halofuginone was administered by the first postoperative day. All animals were sacrificed on day 21; and the results were evaluated by hydroxyproline levels, stenosis index, lumen diameter, histopathological evaluation, wall thickness, and animal weights.


RESULTS
Mortality differences were significant comparing group 3 with group 1 and 2 (P = 0.006) and group 4 (P = 0.03). According to hydroxyproline levels, the differences are significantly higher (P <0.001) comparing group 3 with group 1, 2, and 4. The P value was considered significant in all other parameters (P <0.001) for all the groups but group 1 versus group 2 (P >0.05).


CONCLUSIONS
Halofuginone, a specific inhibitor of collagen type 1 synthesis, significantly reduced esophageal stricture occurrence.
Ozçelik
Mehmet Faik
MF
Department of General Surgery, Istanbul University, Cerrahpasa Medical Faculty, 34622 Istanbul, Turkey. ozcelik@istanbul.edu.tr
Pekmezci
Salih
S
Saribeyoğlu
Kaya
K
Unal
Ethem
E
Gümüştaş
Koray
K
Doğusoy
Gülen
G
D000818:Animals; D002057:Burns, Chemical / Q000150:complications / Q000188:drug therapy*; D002424:Caustics; D024042:Collagen Type I / Q000037:antagonists & inhibitors*; D004940:Esophageal Stenosis / Q000209:etiology / Q000517:prevention & control*; D004947:Esophagus / Q000187:drug effects* / Q000473:pathology; D005355:Fibrosis; D007274:Injections, Intraperitoneal; D008297:Male; D023421:Models, Animal; D010880:Piperidines; D011500:Protein Synthesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D011799:Quinazolines / Q000008:administration & dosage / Q000494:pharmacology*; D052999:Quinazolinones; D051381:Rats; D017207:Rats, Sprague-Dawley; D012972:Sodium Hydroxide
D002424:Caustics; D024042:Collagen Type I; D010880:Piperidines; D011500:Protein Synthesis Inhibitors; D011799:Quinazolines; D052999:Quinazolinones; D012972:Sodium Hydroxide; C010176:halofuginone