In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin.
The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of the drug may be overcome by the use of in situ gel forming systems, which upon instillation as drops into the eye undergo a sol-gel transition in the cul-de-sac. This may result in better ocular availability of the drug. The purpose of this work was to develop an ophthalmic delivery system of the NSAID indomethacin, based on the concept of ion activated in situ gelation. Gelrite gellan gum, a novel ophthalmic vehicle, which gels in the presence of mono or divalent cations present in the lacrimal fluid, was used as the gelling agent. The developed formulations were therapeutically efficacious (in a uveitis induced rabbit eye model) and provided sustained release of the drug over an 8-hour period in vitro.
Balasubramaniam
Jagdish
J
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221 005, India.
Kant
Shri
S
Pandit
Jayanta Kumar
JK
D000818:Animals; D001682:Biological Availability; D003315:Cornea / Q000187:drug effects* / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000494:pharmacology; D004195:Disease Models, Animal; D007213:Indomethacin / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D007267:Injections; D007322:Instillation, Drug; D014677:Pharmaceutical Vehicles; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage* / Q000494:pharmacology; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000009:adverse effects; D013666:Tears / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy; D014822:Vitreous Body
D003692:Delayed-Action Preparations; D014677:Pharmaceutical Vehicles; D011135:Polysaccharides, Bacterial; D012710:Serum Albumin, Bovine; C048288:gellan gum; D007213:Indomethacin