Detection of the Candida antigen mannan in cerebrospinal fluid specimens from patients suspected of having Candida meningitis.
Cerebrospinal fluid samples from five patients from which Candida cells were cultured were tested for the presence of mannan. Samples from four patients categorized as having proven candidosis reacted positively. Samples from the remaining patient and from patients with other central nervous system infections were negative. Detection of mannan may be valuable in the diagnosis of Candida meningitis.
Verduyn Lunel
Frans M
FM
Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands.
Voss
Andreas
A
Kuijper
Ed J
EJ
Gelinck
L B S
LB
Hoogerbrugge
Peter M
PM
Liem
K L
KL
Kullberg
Bart Jan
BJ
Verweij
Paul E
PE
D000368:Aged; D000946:Antigens, Fungal / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008351:Mannans / Q000134:cerebrospinal fluid*; D016921:Meningitis, Fungal / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008875:Middle Aged; D015203:Reproducibility of Results
D000946:Antigens, Fungal; D015415:Biomarkers; D008351:Mannans