title: IS6110-mediated deletion polymorphism in isogenic strains of Mycobacterium tuberculosis.
abstract: Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study provides the first description of an IS6110-mediated deletion event in truly isogenic strains. We also provide further support for the hypothesis that the region from Rv1754 to Rv1765 is a hot spot for IS6110 insertion and deletion events.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Sampson
authors.forename: M
authors.initials: M
authors.lastname: Richardson
authors.forename: P D
authors.initials: PD
authors.lastname: Van Helden
authors.forename: R M
authors.initials: RM
authors.lastname: Warren
mesh_terms: D002876:Chromosomes, Bacterial / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics*; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
chemical_list: D004251:DNA Transposable Elements