title: Latent nystagmus: vestibular nystagmus with a twist.
abstract: BACKGROUND
  Latent nystagmus is a horizontal binocular oscillation that is evoked by unequal visual input to the 2 eyes. It develops primarily in humans with congenital esotropia.
  
  
  OBJECTIVE
  To investigate the interrelationship between latent and peripheral vestibular nystagmus and their corollary neuroanatomical pathways.
  
  
  METHODS
  Examination of subcortical neuroanatomical pathways producing latent nystagmus and review of the neurophysiological mechanisms by which they become activated in congenital esotropia.
  
  
  RESULTS
  The vestibular nucleus presides over motion input from the eyes and labyrinths. Latent nystagmus corresponds to the optokinetic component of ocular rotation that is driven monocularly by nasal optic flow during a turning movement of the body in lateral-eyed animals. Congenital esotropia alters visual pathway development from the visual cortex to subcortical centers that project to the vestibular nucleus, allowing this primitive subcortical motion detection system to generate latent nystagmus under conditions of monocular fixation.
  
  
  CONCLUSIONS
  Latent nystagmus is the ocular counterpart of peripheral vestibular nystagmus. Its clinical expression in humans proclaims the evolutionary function of the eyes as sensory balance organs.
authors.affiliation: Departments of Ophthalmology and Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Brodsky
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Tusa
mesh_terms: D004948:Esotropia / Q000151:congenital / Q000503:physiopathology; D005133:Eye Movements; D006801:Humans; D009759:Nystagmus, Pathologic / Q000150:complications / Q000503:physiopathology; D015837:Vestibular Diseases / Q000150:complications / Q000503:physiopathology