title: Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors.
abstract: The polymer-assisted solution phase synthesis (PASP) of an array of histone deacetylase (HDAc) inhibitors is described. HDAc inhibitors have considerable potential as new anti-proliferative agents. Selected compounds were shown to inhibit both human endothelial cell proliferation, and the formation of tubules (neovascularisation) in an in vitro model of angiogenesis.
authors.affiliation: GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, UK.
authors.forename: Akanksha
authors.initials: A
authors.lastname: Bapna
authors.forename: Emma
authors.initials: E
authors.lastname: Vickerstaffe
authors.forename: Brian H
authors.initials: BH
authors.lastname: Warrington
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow
authors.forename: Tai-Ping D
authors.initials: TP
authors.lastname: Fan
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D018920:Coculture Techniques; D056572:Histone Deacetylase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009389:Neovascularization, Pathologic / Q000473:pathology; D011108:Polymers / Q000737:chemistry*
chemical_list: D056572:Histone Deacetylase Inhibitors; D011108:Polymers