title: Genotypic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates from rural districts of the Western Cape Province of South Africa.
abstract: Genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberculosis isolates from the Western Cape Province of South Africa showed that drug resistance is widespread and recently transmitted. Multidrug-resistant (MDR) isolates comprise 40% of this collection, and a large pool of isoniazid monoresistance may be a future source of MDR tuberculosis.
authors.affiliation: MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg, South Africa.
authors.forename: E M
authors.initials: EM
authors.lastname: Streicher
authors.forename: R M
authors.initials: RM
authors.lastname: Warren
authors.forename: C
authors.initials: C
authors.lastname: Kewley
authors.forename: J
authors.initials: J
authors.lastname: Simpson
authors.forename: N
authors.initials: N
authors.lastname: Rastogi
authors.forename: C
authors.initials: C
authors.lastname: Sola
authors.forename: G D
authors.initials: GD
authors.lastname: van der Spuy
authors.forename: P D
authors.initials: PD
authors.lastname: van Helden
authors.forename: T C
authors.initials: TC
authors.lastname: Victor
mesh_terms: D017931:DNA Primers; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005838:Genotype; D005843:Geography; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D010641:Phenotype; D012424:Rural Population; D013019:South Africa / Q000453:epidemiology; D014376:Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology / Q000635:transmission
chemical_list: D017931:DNA Primers