Coagulopathy in prostate cancer.
Patients with metastatic hormone-refractory prostate carcinoma may have dramatic and life-threatening coagulation complications from their disease. We report here the case of a man with relapsing disseminated intravascular coagulation, and review the different coagulation disorders that may occur during prostatic carcinoma evolution. We focus mainly on disseminated intravascular coagulation (DIC), the most frequent coagulation complication. Other coagulopathies associated with prostate cancer are thrombocytopenic thrombotic purpura, thrombosis, Trousseau's syndrome and acquired factor VIII inhibitor development.
de la Fouchardière
C
C
Department of Medical Oncology, Centre Léon-Bérard, 28 rue Laennec, 69008 Lyon, France.
Flechon
A
A
Droz
J P
JP
D001778:Blood Coagulation Disorders / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000209:etiology; D013927:Thrombosis / Q000209:etiology