title: [Method for improving results of local operations for pyo-necrotic disease of the foot associated with diabetes mellitus].
abstract: Under study was the influence of antimetabolite 5-fluoracil with the preferential influence on the lymphocytic link upon the outcomes of local operations in patients with diabetic foot syndrome. The investigation was performed in 95 diabetes mellitus patients who had undergone local operations for pyo-necrotic diseases of the foot. The group of investigation included 55 patients additionally given 5-fluoracil (5 mg/kg) during local operation. The injection of the drug was followed by moderate lympho- and thrombopenia arrested by the 7th day after a single injection, reduced content of the acute phase reactants and a dramatic drop of the content of circulating immune complexes. Clinically it was followed by a rapid disappearance of the inflammation signs in the wound. In the group of patients given 5-fluoracil there were reliably less reamputations, greater number of wounds healing by primary intention after the first local operation and of those successfully closed with the help of plastic operations. No general toxic effects of the used doses of the drug were noted.
authors.forename: N M
authors.initials: NM
authors.lastname: Grekova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Lebedeva
authors.forename: V N
authors.initials: VN
authors.lastname: Bordunovskiĭ
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000963:Antimetabolites / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D017719:Diabetic Foot / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D013492:Suppuration; D016896:Treatment Outcome
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil