Isolation of 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl) quinolines by Vilsmeier Haack reaction on quinaldines: Construction of diazepino quinoline heterocycles and their antimicrobial and cytogenetic studies.
Application of Vilsmeier conditions to 4-hydroxyquinaldines gives 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl)-quinolines as an intermediate. The latter is utilized to prepare diazepino quinolines on treatment with phenylhydrazine hydrochloride. All the synthesized compounds have been screened for their antibacterial and antifungal as well as cytogenetic activities.
Kumar
Raju Nandha
RN
Department of Chemistry, Bharathiar University, Coimbatore--641 046, India.
Suresh
Thangaraj
T
Mohan
Palathurai Subraminiam
PS
D000328:Adult; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001381:Azepines / Q000737:chemistry; D002478:Cells, Cultured; D020732:Cytogenetic Analysis; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D007097:Imines / Q000737:chemistry; D007202:Indicators and Reagents; D007962:Leukocytes / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D009153:Mutagens; D010659:Phenylhydrazines / Q000737:chemistry; D011798:Quinaldines / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D001381:Azepines; D007097:Imines; D007202:Indicators and Reagents; D009153:Mutagens; D010659:Phenylhydrazines; D011798:Quinaldines; D011804:Quinolines; C030299:phenylhydrazine