title: Evidence of sustained forearm vasodilatation after brief isocapnic hypoxia.
abstract: Healthy subjects exposed to 20 min of hypoxia increase ventilation and muscle sympathetic nerve activity (MSNA). After return to normoxia, although ventilation returns to baseline, MSNA remains elevated for up to an hour. Because forearm vascular resistance is not elevated after hypoxic exposure, we speculated that the increased MSNA might be a compensatory response to sustained release of endogenous vasodilators. We studied the effect of isocapnic hypoxia (mean arterial oxygen saturation 81.6 +/- 4.1%, end-tidal Pco2 44.7 +/- 6.3 Torr) on plethysmographic forearm blood flow (FBF) in eight healthy volunteers while infusing intra-arterial phentolamine to block local alpha-receptors. The dominant arm served as control. Forearm arterial vascular resistance (FVR) was calculated as the mean arterial pressure (MAP)-to-FBF ratio. MAP, heart rate (HR), and FVR were reported at 5-min intervals at baseline, then while infusing phentolamine during room air, isocapnic hypoxia, and recovery. Despite increases in HR during hypoxia, there was no change in MAP throughout the study. By design, FVR decreased during phentolamine infusion. Hypoxia further decreased FVR in both forearms. With continued phentolamine infusion, FVR after termination of the exposure (17.47 +/- 6.3 mmHg x min x ml(-1) x 100 ml of tissue) remained lower than preexposure baseline value (23.05 +/- 8.51 mmHg x min x ml(-1) x 100 ml of tissue; P < 0.05). We conclude that, unmasked by phentolamine, the vasodilation occurring during hypoxia persists for at least 30 min after the stimulus. This vasodilation may contribute to the sustained MSNA rise observed after hypoxia.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. rtamisie@bidmc.harvard.edu
authors.forename: Renaud
authors.initials: R
authors.lastname: Tamisier
authors.forename: Daniel
authors.initials: D
authors.lastname: Norman
authors.forename: Amit
authors.initials: A
authors.lastname: Anand
authors.forename: Yoon
authors.initials: Y
authors.lastname: Choi
authors.forename: J Woodrow
authors.initials: JW
authors.lastname: Weiss
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010313:Partial Pressure; D010991:Plethysmography; D012119:Respiration; D013990:Tidal Volume; D014655:Vascular Resistance; D014664:Vasodilation
chemical_list: D002245:Carbon Dioxide