Chemical modification of manganese porphyrins with biomolecules for new functional antioxidants.
Superoxide dismutase (SOD), which catalyzes the reduction of O2*- to H2O2, is the key enzyme for the protection of oxidative stress. Here we have chemically modified manganese (Mn) porphyrins with biomolecules for new functional antioxidants. The Mn-porphyrins were conjugated with the following biochemical functional molecules: (1) catalase, to catalyze reduction of H2O2 to H2O. The resulting conjugate showed dual functions of SOD and catalase; (2) a carbohydrate, to facilitate receptor binding and, hence, active targeting. The resulting conjugate showed both SOD activity and carbohydrate recognition. These results suggest that the antioxidants promise the application to biomedical fields.
Asayama
S
S
Department of Applied Chemistry, Tokyo Metropolitan University. Minami-Osawa, Hachioji, Tokyo 192-0397, Japan.
Mori
T
T
Nagaoka
S
S
Kawakami
H
H
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry; D002374:Catalase / Q000378:metabolism; D002417:Cattle; D007700:Kinetics; D008345:Manganese / Q000737:chemistry*; D015394:Molecular Structure; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002241:Carbohydrates; D011166:Porphyrins; D008345:Manganese; D002374:Catalase; D013482:Superoxide Dismutase