title: Some metabolic abnormalities in type 2 diabetic patients in Jos, north central Nigeria.
abstract: BACKGROUND
  Diabetes mellitus is associated with derangements in the serum levels of several biochemical parameters. This study was conducted in an attempt to obtain the biochemical profiles and their abnormalities in Nigerian type 2 diabetic patients in Jos, North Central Nigeria.
  
  
  METHODS
  Seventy-five (75) Nigerians with type 2 diabetes mellitus and 69 age and sex-matched non-diabetic controls were investigated. Each participant had fasting plasma glucose, plasma lipids, liver, renal function profiles as well as their clinical characteristics assessed.
  
  
  RESULTS
  The clinical characteristics body mass index, waist hip ratio and blood pressures were significantly higher in diabetics than controls (p < 0.05). Renal and lipid profiles were also significantly higher in diabetics. There was no significant difference in the liver profile between diabetics and controls. Diabetics with good glycaemic control had lower frequencies of biochemical abnormalities compared to diabetics with poor control.
  
  
  CONCLUSIONS
  Metabolic abnormalities are common in Nigerians with type 2 diabetes. Our findings support the fact that controlling hyperglycaemic state would be beneficial in preventing the major metabolic abnormalities and hence the complications of diabetes mellitus.
authors.affiliation: Department of Medicine, Faculty of Medical Sciences, University of Jos, Nigeria.
authors.forename: F H
authors.initials: FH
authors.lastname: Puepet
authors.forename: E I
authors.initials: EI
authors.lastname: Agaba
authors.forename: E K
authors.initials: EK
authors.lastname: Chuhwak
mesh_terms: D017677:Age Distribution; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000378:metabolism*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology*; D006949:Hyperlipidemias / Q000453:epidemiology*; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008659:Metabolic Diseases / Q000453:epidemiology; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D017678:Sex Distribution