title: Markedly prolonged jaundice from simultaneous infection with hepatitis E virus and leptospira.
abstract: We treated a patient simultaneously infected with hepatitis E virus and Leptospira interrogans, both acquired in China. Severe hyperbilirubinemia required nearly 200 days to resolve, transminase elevation showed a fluctuating course, and liver biopsy specimens showed fibrosis unusual for hepatitis E. Leptospirosis appeared to have altered the course of hepatitis E virus infection in this patient, even though infection with Leptospira was cleared with antibiotics by 50 days after the onset of the hepatitis symptoms.
authors.affiliation: Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
authors.forename: Asuka
authors.initials: A
authors.lastname: Suzuki
authors.forename: Ryukichi
authors.initials: R
authors.lastname: Kumashiro
authors.forename: Miki
authors.initials: M
authors.lastname: Shirachi
authors.forename: Mina
authors.initials: M
authors.lastname: Kuroki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Kyuichi
authors.initials: K
authors.lastname: Tanikawa
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
mesh_terms: D016751:Hepatitis E / Q000150:complications* / Q000473:pathology; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D007921:Leptospira interrogans; D007922:Leptospirosis / Q000150:complications*; D008297:Male; D008875:Middle Aged