title: Interventional radiology for renovascular hypertension in children.
abstract: Pediatric renovascular hypertension is an uncommon but important clinical problem. Atherosclerosis is rare in children, who typically suffer from fibromuscular dysplasia, neurofibromatosis type 1, Williams syndrome, or certain other rare conditions. Children with renovascular disease often have involvement of other arteries including the aorta and mesenteric and cerebral vessels. The pediatric interventional radiology service has a vital role in the diagnosis, evaluation, and treatment of renovascular hypertension. Renal vein renin sampling appears to be more useful in children than in adults, because their arterial disease is more often bilateral and segmental. Diagnostic angiography is still superior to less-invasive methods of imaging the renal arteries, especially the smaller branches. Interventional options include angioplasty, stenting, and ethanol ablation. Angioplasty is almost always technically successful and usually gives a worthwhile clinical improvement. Stenting is only used in children when angioplasty fails. Ethanol embolization may be appropriate in children with focal renin-producing areas that are untreatable by angioplasty.
authors.affiliation: Department of Radiology, Great Ormond Street Hospital, London, United Kingdom. mclarc@gosh.nhs.uk
authors.forename: Clare A
authors.initials: CA
authors.lastname: McLaren
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Roebuck
mesh_terms: D000800:Angioplasty, Balloon; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D001027:Aortography; D002648:Child; D002675:Child, Preschool; D000431:Ethanol / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000175:diagnosis* / Q000628:therapy; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging*; D008297:Male; D015642:Radiology, Interventional / Q000379:methods*; D012083:Renin / Q000032:analysis; D015607:Stents
chemical_list: D000891:Anti-Infective Agents, Local; D000431:Ethanol; D012083:Renin