title: Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome.
abstract: This report demonstrates that a rapid decrease of peripheral T cell subsets is a unique characteristic in patients with SARS during acute infection, although total white blood cell counts, red blood cell counts, and platelet counts remain relatively normal. In recovering patients, a rapid and dramatic restoration of peripheral T cell subsets was seen in the periphery. Although the underlying mechanism of the acute decrease of peripheral T cell subsets observed in patients with SARS during the acute stage remains unknown, this clinical characteristic can facilitate an earlier and more accurate diagnosis of SARS.
authors.affiliation: Department of Infectious Diseases, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Beijing, China 100730. tli@21cn.com
authors.forename: Taisheng
authors.initials: T
authors.lastname: Li
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Qiu
authors.forename: Linqi
authors.initials: L
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Zhengyin
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Ma
authors.forename: Hongwei
authors.initials: H
authors.lastname: Fan
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Huanling
authors.initials: H
authors.lastname: Wang
authors.forename: Guohua
authors.initials: G
authors.lastname: Deng
authors.forename: Aixia
authors.initials: A
authors.lastname: Wang
mesh_terms: D015703:Antigens, CD / Q000097:blood; D017252:CD3 Complex / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D018655:Lymphocyte Count; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000503:physiopathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D017252:CD3 Complex