Successful unrelated cord blood transplantation following reduced-intensity conditioning for refractory acute myeloid leukemia.
Patients with relapsed acute myeloid leukemia following autograft have a poor prognosis. The possibility of allograft is frequently time-limited, as the disease reappears before a stem cell donor can be found in the worldwide registries. Cord blood transplantation is a new therapeutic approach, since cord blood units are rapidly available. The authors show how a relapsed chemotherapy-refractory patient was successful transplanted with a mismatched cord blood unit after reduced-intensity conditioning. Twenty-three months after transplantation, the child is in continuous complete remission and has full donor chimerism and no signs of chronic graft-versus-host disease.
Berger
Massimo
M
Department of Paediatrics, Regina Margherita Children's Hospital, University of Turin, Italy.
Vassallo
Elena
E
Nesi
Francesca
F
Venturi
Claudio
C
Madon
Enrico
E
Fagioli
Franca
F
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D006086:Graft vs Host Disease / Q000517:prevention & control; D020544:Graft vs Leukemia Effect / Q000276:immunology; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D012074:Remission Induction; D019172:Transplantation Conditioning; D016896:Treatment Outcome