title: [Research of cross-linking reagent for producing hyaluronic acid derivative].
abstract: OBJECTIVE
  To review the recent advances of cross-linking reagent for producing hyaluronic acid (HA) derivative so as to provide more advice for the development of HA reagent.
  
  
  METHODS
  Recent original articles related to the species, characteristic, cross-linking methodology and mechanism of the cross-linking reagent to producing HA derivative were summarized and systematically analyzed.
  
  
  RESULTS
  The derivatives after special kinds of reagents modification would remain their own good biocompatibility and change their original rheololgical characterization and obtain relative long organism residence time.
  
  
  CONCLUSIONS
  Development of hyaluronic derivatives may widen their medical application.
authors.affiliation: Shanghai Qisheng Biomaterial Institute, Shanghai, P. R. China 201106.
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Chen
authors.forename: Cong
authors.initials: C
authors.lastname: Lin
authors.forename: Qi-sheng
authors.initials: QS
authors.lastname: Gu
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D003432:Cross-Linking Reagents / Q000737:chemistry; D020723:Glucuronic Acid; D006820:Hyaluronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000145:classification
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D020723:Glucuronic Acid; D006820:Hyaluronic Acid