title: Mycoplasma genitalium in chronic non-gonococcal urethritis.
abstract: Seventy-eight men with a history of chronic urethritis were referred for investigation. Of 52 men diagnosed as having persistent or recurrent non-gonococcal urethritis (NGU) at the time of referral, 11 (21%) were infected with Mycoplasma genitalium and three with Chlamydia trachomatis. Men who were M. genitalium-positive had not previously received less antibiotic, in terms of treatment duration, than those who were M. genitalium-negative, suggesting a possible resistance to the antibiotics given. In the current investigation, of 11 M. genitalium-positive men with persistent or recurrent NGU who were treated for four to six weeks with erythromycin, 500 mg four times daily, nine (82%) responded clinically and microbiologically, but later six relapsed without M. genitalium being detected. The results of observing and investigating a patient for about one year, the only one to have concurrent chlamydial and mycoplasmal infections, is presented, a feature being the intermittent persistence of the mycoplasma.
authors.affiliation: Division of Medicine, Imperial College London, St Mary's Hospital, London W2 1NY, UK.
authors.forename: D
authors.initials: D
authors.lastname: Taylor-Robinson
authors.forename: C B
authors.initials: CB
authors.lastname: Gilroy
authors.forename: B J
authors.initials: BJ
authors.lastname: Thomas
authors.forename: P E
authors.initials: PE
authors.lastname: Hay
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D002908:Chronic Disease; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000627:therapeutic use; D006801:Humans; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D045704:Mycoplasma genitalium / Q000302:isolation & purification; D012008:Recurrence; D014526:Urethritis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D004917:Erythromycin