The effects of starches on mechanical properties of paracetamol tablet formulations. I. Pregelatinization of starch binders.
A study has been made of the effects of pregelatinization of native sorghum and plantain starches on the mechanical properties of a paracetamol tablet formulation in comparison with corn starch BP. The mechanical properties tested, viz. tensile strength (T) and brittle fracture index (BFI) of the paracetamol tablets were affected by pregelatinization of the starch. The results suggest that pregelatinized starches may be useful as binders when a particular degree of bond strength and brittleness is desired.
Alebiowu
Gbenga
G
Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria. galebiowu@yahoo.co.uk
Itiola
Oludele Adelanwa
OA
D000082:Acetaminophen / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D019563:Mechanics; D045868:Sorghum / Q000737:chemistry; D013213:Starch / Q000737:chemistry*; D013607:Tablets; D013718:Tensile Strength; D003313:Zea mays / Q000737:chemistry
D013607:Tablets; D000082:Acetaminophen; D013213:Starch