title: Tracheobronchial amyloidosis: a case report of successful treatment with external beam radiation therapy.
abstract: Tracheobronchial amyloidosis (TBA) refers to the deposition of localized amyloid deposits within the upper airways. Treatments have historically focused on bronchoscopic techniques including debridement, laser ablation, balloon dilation, and stent placement. Local excisions often prove temporarily effective, with multiple local recurrences and progressive compromise pulmonary function occurring frequently. We present a case of TBA managed with definitive external beam radiation therapy. Eighteen months after moderate-dose radiation, the patient demonstrated improvements in functional status, pulmonary function, bronchoscopic visualization, and CT-based luminal diameters. The literature involving the role of radiation therapy in the treatment of TBA is reviewed.
authors.affiliation: Department of Radiation Oncology, University of Florida College of Medicine, Health Science Center, Gainesville, FL 32610-0385, USA.
authors.forename: Alan T
authors.initials: AT
authors.lastname: Monroe
authors.forename: Rajat
authors.initials: R
authors.lastname: Walia
authors.forename: Robert A
authors.initials: RA
authors.lastname: Zlotecki
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jantz
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000532:radiotherapy*; D001918:Brachytherapy / Q000379:methods*; D001982:Bronchial Diseases / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy*; D001999:Bronchoscopy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D011879:Radiotherapy Dosage; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014133:Tracheal Diseases / Q000150:complications / Q000175:diagnosis / Q000532:radiotherapy*; D016896:Treatment Outcome