Studies on thiazolopyridines--a novel synthesis of bis-thiazolopyridines as promising antimicrobial agents.
A variety of novel bis-thiazolopyridine derivatives 4a-e were synthesized via the reaction of bis-thiazolinone 3 with different arylcinnamonitrile derivatives (1:2 molar ratio), whereas the reaction of bis-compounds 7a-e with malononitrile in ethanol solution containing a few drops of piperidine afforded the novel bis-thiazolopyridines 8a-e. The structures of the synthesized compounds were established by elemental analyses and spectral data. Some of the newly synthesized compounds show moderate to high antimicrobial activity.
Azab
Mohamed E
ME
Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
El-Hag Ali
Gameel A M
GA
Abd El-Wahab
Ashraf H F
AH
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000890:Anti-Infective Agents; D011725:Pyridines; D013844:Thiazoles