Eosinophil function in allergic inflammation: from bone marrow to tissue response.
The role of the eosinophil in the pathophysiology of allergy and asthma has been the focus of intense interest during the past two decades. Although the presence of eosinophils in humans with allergy and asthma is well established, the precise role of this cell in human and animal tissue response is still unclear. However, recent developments in research on many organ systems have provided novel insights into the possible underlying role of the eosinophil in both allergic and nonallergic inflammation. In this review, we examine the pathways associated with eosinophil recruitment and activation, and discuss these findings with reference to clinically defined categories.
Adamko
Darryl
D
Department of Medicine, 550A HMRC, University of Alberta, Edmonton, AB T6G 2S2, Canada. Redwan.Moqbel@ualberta.ca
Lacy
Paige
P
Moqbel
Redwan
R
D000818:Animals; D001853:Bone Marrow / Q000503:physiopathology; D015550:Cell Degranulation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D018925:Chemokines / Q000378:metabolism; D004802:Eosinophilia / Q000378:metabolism / Q000503:physiopathology; D004804:Eosinophils / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism / Q000503:physiopathology*; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D012130:Respiratory Hypersensitivity / Q000378:metabolism / Q000503:physiopathology
D018925:Chemokines