Review of microdialysis in brain tumors, from concept to application: first annual Carolyn Frye-Halloran symposium.
In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily reflect concentrations within the tumor and adjacent brain. This review article introduces to neurological and medical oncologists, as well as pharmacologists, the application of microdialysis in monitoring drug metabolism and delivery within the fluid of the interstitial space of brain tumor and its surroundings. Microdialysis samples soluble molecules from the extracellular fluid via a semipermeable membrane at the tip of a probe. In the past decade, it has been used predominantly in neurointensive care in the setting of brain trauma, vasospasm, epilepsy,and intracerebral hemorrhage. At the first Carolyn Frye-Halloran Symposium held at Massachusetts General Hospital in March 2002, the concept of microdialysis was extended to specifically address its possible use in treating brain tumor patients. In doing so we provide a rationale for the use of this technology by a National Cancer Institute consortium, New Approaches to Brain Tumor Therapy, to measure levels of drugs in brain tissue as part of phase 1 trials.
Benjamin
Ramsis K
RK
Brain Tumor Center, Massachusetts General Hospital, Boston, MA 02114, USA. Ramsis.benjamin@cnsa.com
Hochberg
Fred H
FH
Fox
Elizabeth
E
Bungay
Peter M
PM
Elmquist
William F
WF
Stewart
Clinton F
CF
Gallo
James M
JM
Collins
Jerry M
JM
Pelletier
Robert P
RP
de Groot
John F
JF
Hickner
Robert C
RC
Cavus
Idil
I
Grossman
Stuart A
SA
Colvin
O Michael
OM
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D017321:Clinical Trials, Phase I as Topic / Q000295:instrumentation / Q000379:methods / Q000592:standards; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods / Q000592:standards; D006801:Humans; D017551:Microdialysis / Q000295:instrumentation / Q000379:methods* / Q000592:standards*
D000970:Antineoplastic Agents