title: Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid.
abstract: Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, 72076 Tübingen, Germany. wolfgang.krueger@uni-tuebingen.de
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Krueger
authors.forename: Bernd
authors.initials: B
authors.lastname: Kottler
authors.forename: Bernd E
authors.initials: BE
authors.lastname: Will
authors.forename: Alexandra
authors.initials: A
authors.lastname: Heininger
authors.forename: Heinz
authors.initials: H
authors.lastname: Guggenberger
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Unertl
mesh_terms: D000063:Accidents, Traffic; D000081:Acetamides / Q000627:therapeutic use*; D000293:Adolescent; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy; D005260:Female; D006801:Humans; D000069349:Linezolid; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D016106:Methicillin Resistance / Q000235:genetics*; D023303:Oxazolidinones / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid