A case of sectorial benign flecked retina.
OBJECTIVE
A case of sectorial benign flecked retina not associated with an RDH5 gene mutation is reported.


METHODS
A 51-year-old woman showed multiple yellow-white flecks in both eyes similar to those of benign flecked retina but in only the upper half of the retina. We carried out clinical, electrophysiological, and molecular genetic examinations of the patient.


RESULTS
Visual acuity was 20/20 OD and 20/20 OS. Fluorescein angiography showed diffuse irregular hypofluorescence that did not correspond to the flecked lesions. A Goldmann-Weeker adaptometer test revealed that the visual threshold of the upper retina was approximately 0.6 to 0.8 log units higher than that of the lower retina. No mutations of the RDH5 gene were detected in exons 2-5 or in the flanking intron sequences.


CONCLUSIONS
To our knowledge, this is the first report of sectorial benign flecked retina, and the flecks may not be caused by an RDH5 gene mutation.
Tsuchiya
Takako
T
Department of Ophthalmology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Kato
Masaru
M
Tomita
Natsuyo
N
Koide
Kenro
K
Hata
Norimasa
N
Sato
Miho
M
Hotta
Yoshihiro
Y
Ueno
Makoto
M
Nakamura
Makoto
M
Miyake
Yozo
Y
D000429:Alcohol Oxidoreductases / Q000235:genetics; D003623:Dark Adaptation; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008875:Middle Aged; D012164:Retinal Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D014792:Visual Acuity
D000429:Alcohol Oxidoreductases; C022520:retinol dehydrogenase