title: Anal canal cancer and chemoradiation treatment in two patients with systemic lupus erythematosus treated by chronic therapeutic immunosuppression.
abstract: Two case reports of anal cancer developing during chronic therapeutic immunosuppression for systemic lupus erythematosus (SLE) and their cancer management are presented. The complex issues of delivery of curative chemoradiation treatment for anal cancer in the context of co-existing autoimmune connective tissue disease (AICD) are discussed. These two cases show that combined chemotherapy and radiation regimens are possible in patients with SLE. However, frequent, careful assessment with judicious and prompt management of haematological and other complications during treatment is important.
authors.affiliation: Department of Academic Radiation Oncology, Christie Hospital NHS Trust, Manchester, UK. vincent.khoo@man.ac.uk
authors.forename: V S
authors.initials: VS
authors.lastname: Khoo
authors.forename: M P
authors.initials: MP
authors.lastname: Saunders
authors.forename: R
authors.initials: R
authors.lastname: Gowda
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: B J
authors.initials: BJ
authors.lastname: Cummings
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents