title: Dissociation between carotid artery lesions and lipid parameters in recipients of successful kidney graft.
abstract: BACKGROUND
  The relationships between lipid levels and atherosclerotic lesions of carotid arteries in kidney graft recipients are still unclear.
  
  
  METHODS
  We evaluated carotid morphology in 53 recipients of functioning renal transplantation, and studied the relationship of carotid artery wall lesions with relevant clinical and laboratory risk factors for cardiovascular disease. The patients were on stable, cyclosporine-based immunosuppressive therapy.
  
  
  RESULTS
  The main clinical characteristics of patients were: age, 46.5 +/- 10.1 years; males/females, 40/13; body mass index, 25.8 +/- 4.4 kg/m2; duration of transplantation, 43 +/- 52 months. Ultrasonographic scanning of carotid arteries showed the presence of lesions (intimal-media thickness and/or plaque) in 28 patients (52.8%). These recipients differed from patients without carotid lesions in terms of age (50.4 +/- 9.0 vs 42.2 +/- 9.7 years, p < 0.01) and duration of pre-transplant dialysis (4.6 +/- 3.4 vs 2.3 +/- 1.9 years, p < 0.01), whereas no statistically significant difference was observed as for total cholesterol (230 +/- 44 vs 235 +/- 35 mg/dl), LDL-cholesterol (142 +/- 32 vs 143 +/- 30 mg/dl), HDL-cholesterol (52 +/- 12 vs 58 +/- 20 mg/dl) and triglycerides (178 +/- 94 vs 167 +/- 89 mg/dl). The percentage of post-transplant diabetes was 3-fold higher in patients with carotid lesions (25 vs 8%). No difference was observed as for the following parameters: body mass index, duration of transplantation, fibrinogen levels, DDimer concentrations, reactive C-protein values, prevalence of hypertension, percentage of smokers vs non-smokers.
  
  
  CONCLUSIONS
  The present study supports the view that carotid artery lesions in kidney graft recipients on stable, cyclosporine-based immunosuppressive therapy may not be related to circulating lipid values.
authors.affiliation: Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy. giannaro@immr.med.unipi.it
authors.forename: R
authors.initials: R
authors.lastname: Giannarelli
authors.forename: A
authors.initials: A
authors.lastname: Coppelli
authors.forename: M
authors.initials: M
authors.lastname: Aragona
authors.forename: U
authors.initials: U
authors.lastname: Boggi
authors.forename: V
authors.initials: V
authors.lastname: Napoli
authors.forename: F
authors.initials: F
authors.lastname: Donadio
authors.forename: G
authors.initials: G
authors.lastname: Paleologo
authors.forename: C
authors.initials: C
authors.lastname: Tregnaghi
authors.forename: G
authors.initials: G
authors.lastname: Rizzo
authors.forename: F
authors.initials: F
authors.lastname: Mosca
authors.forename: S
authors.initials: S
authors.lastname: Del Prato
authors.forename: P
authors.initials: P
authors.lastname: Marchetti
mesh_terms: D000328:Adult; D001161:Arteriosclerosis / Q000473:pathology*; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007166:Immunosuppressive Agents; D008055:Lipids; D014280:Triglycerides; D016572:Cyclosporine; D002784:Cholesterol