Efficient resolution of 2,2'-dihydroxy-1,1'-binaphthyl by inclusion complexation with chiral N-(3-chloro-2-hydroxypropyl)-N,N,N-trimethylammonium chloride.
The complete resolution of 2,2[prime or minute]-dihydroxy-1,1[prime or minute]-binaphthyl into its enantiomers by inclusion complexation with a commercially available derivative of choline, is reported. The two enantiomers are recovered in >99% ee from the inclusion complexes by simple dissolution in a diethyl ether-water medium and the resolving agent can be recycled.
Toda
Fumio
F
Department of Chemistry, Faculty of Science, Okayama University of Science, Okayama 700-0005, Japan. toda@chem.ous.ac.jp
Yoshizawa
Kazuhiro
K
Hyoda
Shunji
S
Toyota
Shinji
S
Chatziefthimiou
Spyros
S
Mavridis
Irene M
IM