Restricted expression of endogenous N-tropic XC-positive leukemia virus in hybrids between G and AKR mice: an effect of the Fv-4r gene.
G mice carrying the Fv-4r gene are resistant to exogenous infections of various strains of ecotropic MuLVs (Suzuki, 1975). The expression of endogenous N-tropic XC-positive virus was studied in the progency of a cross between G and AKR mice. In the F1 mice, the virus expression was almost completely supressed, and no leukemia developed during 1 year of observation. Results of successive backcrossings with AKR mice indicated that a single dominant gene, the Fv-4r suffices for supression. It can be concluded that the extensive growth of N-tropic XC-positive virus is a prerequisite for leukemia development in AKR mice.
Odaka
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T
Institute of Medical Science, Shirokanedai 4-6-1, Minato-ku, Tokyo 108, Japan.
Ikeda
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H
Akatsuka
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T
D000818:Animals; D003433:Crosses, Genetic; D004622:Embryo, Mammalian; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D005622:Friend murine leukemia virus / Q000235:genetics* / Q000302:isolation & purification; D007942:Leukemia, Experimental / Q000235:genetics / Q000821:virology*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D010375:Pedigree
C103555:Fv4 protein, mouse; D008565:Membrane Proteins