Acquisition of high-risk human papillomavirus infections and pap smear abnormalities among women in the New Independent States of the Former Soviet Union.
The rates of acquisition and the times of incident high-risk (HR) human papillomavirus (HPV) infections and Pap smear abnormalities and their predictive factors were analyzed in women participating in a multicenter screening study in three countries of the New Independent States of the former Soviet Union. The 423 patients were prospectively monitored for a mean of 21.6 months. At the baseline, 118 women were HR HPV DNA negative (Hybrid Capture II assay) and Pap smear negative (group 1), 184 were HPV DNA positive and Pap smear negative (group 2), and 121 were HPV DNA negative and Pap smear positive (group 3). The time to the acquisition of an incident abnormal Pap smear (19.4 months) was significantly longer in group 1 than in group 2 (9.2 months) (P = 0.0001). The times of acquisition of incident HR HPV infection were 16.6 and 11.0 months in group 1 and group 3, respectively (P = 0.006). The monthly rates of acquisition of incident HR HPV infections were very similar in group 1 (1.0%) and group 3 (0.8%), whereas the rate of acquisition of an abnormal Pap smear was significantly higher in group 2 (3.1%) than in group 1 (1.5%) (P = 0.0001). The acquisition of HR HPV infection (but not a positive Pap smear result) was significantly (P = 0.0001) age dependent. The only significant independent (P = 0.001) predictor of the incidence of an abnormal Pap smear result was a high HR HPV load of >20 relative light units/control value (CO) (rate ratio, 2.050; 95% confidence interval, 1.343 to 3.129). Independent predictors of incident HR HPV infection were patient category (a sexually transmitted disease) and ever having been pregnant. The time of acquisition of HR HPV infection was 3 months shorter than that of an abnormal Pap smear. At the baseline the high load of a particular HR HPV type is the single most important predictor of an incident Pap smear abnormality, whereas young age and having a sexually transmitted disease predict incident HR HPV infections.
Syrjänen
Stina
S
Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku, Turku, Finland. stina.syrjanen@utu.fi
Shabalova
Irena
I
Petrovichev
Nicolay
N
Kozachenko
Vladimir
V
Zakharova
Tatjana
T
Pajanidi
Julia
J
Podistov
Jurij
J
Chemeris
Galina
G
Sozaeva
Larisa
L
Lipova
Elena
E
Tsidaeva
Irena
I
Ivanchenko
Olga
O
Pshepurko
Alla
A
Zakharenko
Sergej
S
Nerovjna
Raisa
R
Kljukina
Ludmila
L
Erokhina
Oksana
O
Branovskaja
Marina
M
Nikitina
Maritta
M
Grunberga
Valerija
V
Grunberg
Alexandr
A
Juschenko
Anna
A
Tosi
Piero
P
Cintorino
Marcella
M
Santopietro
Rosa
R
Syrjänen
Kari
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology*; D013997:Time Factors; D014586:USSR / Q000453:epidemiology; D014626:Vaginal Smears
D004279:DNA, Viral