Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome.
This report demonstrates that a rapid decrease of peripheral T cell subsets is a unique characteristic in patients with SARS during acute infection, although total white blood cell counts, red blood cell counts, and platelet counts remain relatively normal. In recovering patients, a rapid and dramatic restoration of peripheral T cell subsets was seen in the periphery. Although the underlying mechanism of the acute decrease of peripheral T cell subsets observed in patients with SARS during the acute stage remains unknown, this clinical characteristic can facilitate an earlier and more accurate diagnosis of SARS.
Li
Taisheng
T
Department of Infectious Diseases, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Beijing, China 100730. tli@21cn.com
Qiu
Zhifeng
Z
Zhang
Linqi
L
Han
Yang
Y
He
Wei
W
Liu
Zhengyin
Z
Ma
Xiaojun
X
Fan
Hongwei
H
Lu
Wei
W
Xie
Jing
J
Wang
Huanling
H
Deng
Guohua
G
Wang
Aixia
A
D015703:Antigens, CD / Q000097:blood; D017252:CD3 Complex / Q000097:blood; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D018655:Lymphocyte Count; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000503:physiopathology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D017252:CD3 Complex