[Hepatitis C virus infection and primary hepatic large B-cell lymphoma: a non-fortuitous association. Case report and review of literature].
We report a case of hepatitis C virus infection in association with primary hepatic large B-cell non-Hodgkin's lymphoma. Primary hepatic non-Hodgkin's lymphoma is a rare disease. Association of hepatitis C virus infection with primary hepatic B-cell non-hodgkin's lymphoma is probably not fortuitous. Indeed, in case of primary hepatic non-hodgkin's lymphoma' patients are often hepatitis C virus positive. Moreover, several studies have reported a high prevalence of chronic hepatitis C virus infection among patients with B-cell non-Hodgkin's lymphoma whatever the localization of the lymphoma. A recent study found a high rate of remission of a splenic form of lymphoma after treatment of hepatitis C virus infection. Our case report confirms the hypothesis of a key role of hepatitis C virus in the pathogenesis of various forms of B-cell lymphoproliferative disorders and in particular in primary hepatic lymphoma.
Condat
Bertrand
B
Service d'hépato-gastroentérologie, Hôpital Saint-Camille, Bry sur Marne. B.Condat@ch-bry.org
Bonnet
Joëlle
J
Hauuy
Marie-Pierre
MP
Collot
Véronique
V
Charlier
Alain
A
Dugue
Laurent
L
Ngo
Yan
Y
Maftouh
Anouar
A
Diche
Thierry
T
Bandin
Olivia
O
Guigui
Bernard
B
Asli
Bouchra
B
Blazquez
Martine
M
D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000503:physiopathology / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000503:physiopathology / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000503:physiopathology / Q000821:virology*