Recombination in uveitis-causing enterovirus strains.
The complete nucleotide sequences of three human echovirus (EV) 11 strains and one EV19 strain, all of which caused outbreaks of enterovirus uveitis (EU), a new infant disease first identified in 1980 in Siberia, were determined. One EV11 strain which caused an outbreak of sepsis-like disease in Hungary was also sequenced. All four EV11 strains were mosaic recombinants of the prototype EV11 strain Gregory, with their non-structural coding regions and 5' NTRs being more similar to other prototype enteroviruses (EV1, EV9). However, this finding is probably a feature of all circulating enterovirus strains and may not be related to their altered virulence. A full genome sequence comparison of the three subtypes of EU-causing strains excludes the role of recent recombination in their emergence, and points to their independent emergence.
Lukashev
A N
AN
Department of Biochemistry and Pharmacy, Åbo Akademi University, PO Box 66, FIN-20521 Turku, Finland.|Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow 142782, Russia.
Lashkevich
V A
VA
Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow 142782, Russia.
Koroleva
G A
GA
Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow 142782, Russia.
Ilonen
J
J
Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN-20520 Turku, Finland.
Hinkkanen
A E
AE
Department of Biochemistry and Pharmacy, Åbo Akademi University, PO Box 66, FIN-20521 Turku, Finland.
D020121:5' Untranslated Regions; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D029822:Enterovirus B, Human / Q000235:genetics* / Q000302:isolation & purification; D016679:Genome, Viral; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007223:Infant; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D010802:Phylogeny; D011995:Recombination, Genetic; D012426:Russia / Q000453:epidemiology; D018805:Sepsis / Q000473:pathology; D012800:Siberia; D014605:Uveitis / Q000453:epidemiology / Q000821:virology*
D020121:5' Untranslated Regions; D015345:Oligonucleotide Probes