title: Lack of protective effects of interleukin-4 -589-C/T polymorphism against HIV-1-related disease progression and central nervous system impairment, in children.
abstract: The interleukin (IL)-4 -589-C/T polymorphism has been reported to protect against human immunodeficiency virus type 1 (HIV-1)-related disease progression in white adults. In the present study, the effect of the IL-4 -589 polymorphism on HIV-1-related disease progression was evaluated in a seroprevalent cohort of 1043 children. The IL-4 -589-T allele was more prevalent in Hispanic and in black, non-Hispanic children, compared with white, non-Hispanic children. We found that the IL-4 -589-C/T polymorphism does not affect the risk of HIV-1-related disease progression or central nervous system impairment in children, and this did not differ by race/ethnicity. Our findings suggest that the IL-4 -589-C/T polymorphism is not an important determinant of HIV-1 disease progression in children.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, University of California-San Diego, La Jolla, CA 92093-0672, USA.
authors.forename: Kumud K
authors.initials: KK
authors.lastname: Singh
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hughes
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Spector
mesh_terms: D015526:AIDS Dementia Complex / Q000235:genetics*; D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000503:physiopathology; D044383:Black People; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007223:Infant; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014481:United States; D044465:White People; D001741:Black or African American
chemical_list: D015847:Interleukin-4