title: Antibodies to non-bilayer phospholipid arrangements induce a murine autoimmune disease resembling human lupus.
abstract: Antibodies recognizing non-bilayer phospholipid arrangements (NPA) in membrane models and in cell membranes in vivo, triggered an autoimmune-like disease in mice. This exhibited features similar to human lupus and was induced by injecting mice either with the H308 monoclonal antibody specific to NPA, with sera from mice which already had developed the autoimmune disease, or with liposomes treated with the NPA inductors chlorpromazine or procainamide; or with these NPA inductors alone. All these procedures revealed the involvement of antibodies to non-bilayer phospholipids in inducing this autoimmune-like disease. Unraveling the mechanisms of these antibodies might contribute to a better understanding of the molecular and immunological basis of autoimmune diseases like lupus and, hopefully, towards the development of better therapeutic strategies.
authors.affiliation: Department of Biochemistry, National School of Biological Sciences, National Polytechnic Institute, México City, México. ibaeza@encb.ipn.mx
authors.forename: Isabel
authors.initials: I
authors.lastname: Baeza
authors.forename: Emma
authors.initials: E
authors.lastname: Leyva
authors.forename: Begoña
authors.initials: B
authors.lastname: Campos
authors.forename: Mónica
authors.initials: M
authors.lastname: Lara
authors.forename: Miguel
authors.initials: M
authors.lastname: Ibáñez
authors.forename: Norberto
authors.initials: N
authors.lastname: Farfán
authors.forename: Héctor
authors.initials: H
authors.lastname: Orozco
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Flores-Romo
authors.forename: Rogelio
authors.initials: R
authors.lastname: Hernández-Pando
authors.forename: Carlos
authors.initials: C
authors.lastname: Wong
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000276:immunology; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D002746:Chlorpromazine / Q000009:adverse effects / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D008081:Liposomes / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010743:Phospholipids / Q000276:immunology*; D011342:Procainamide / Q000009:adverse effects / Q000276:immunology; D013047:Specific Pathogen-Free Organisms
chemical_list: D000889:Anti-Arrhythmia Agents; D014150:Antipsychotic Agents; D001323:Autoantibodies; D008081:Liposomes; D010743:Phospholipids; D011342:Procainamide; D002746:Chlorpromazine