title: Effect of methylphenidate on time perception in children with attention-deficit/hyperactivity disorder.
abstract: The effects of methylphenidate (MPH) on performance of a time-production task were studied in 17 children with attention-deficit/hyperactivity disorder who participated in 1 test session on and 1 off MPH. Participants held a response lever down for at least 10 but no longer than 14 s. Administration of MPH had no effect on the number of correct responses or on the mean duration of lever holds. MPH administration significantly decreased timing response variability, increased holds of 10- to 11-s duration, and decreased lever holds of extremely short durations. These results indicate that administration of MPH resulted in more precise timing performance without changing the mean duration of lever holds, suggesting an enhancement in working memory.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences--Arkansas Children's Hospital, Little Rock, AR 72202, USA. baldwinronaldL@uams.edu
authors.forename: Ronald L
authors.initials: RL
authors.lastname: Baldwin
authors.forename: John J
authors.initials: JJ
authors.lastname: Chelonis
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Flake
authors.forename: Mark C
authors.initials: MC
authors.lastname: Edwards
authors.forename: Charles R
authors.initials: CR
authors.lastname: Feild
authors.forename: Julie B
authors.initials: JB
authors.lastname: Meaux
authors.forename: Merle G
authors.initials: MG
authors.lastname: Paule
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D002648:Child; D003216:Conditioning, Operant / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D008774:Methylphenidate / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D013998:Time Perception / Q000187:drug effects*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate