title: Relationship of plasma HIV-1 RNA dynamics to baseline factors and virological responses to highly active antiretroviral therapy in adolescents (aged 12-22 years) infected through high-risk behavior.
abstract: We characterized the viral dynamics of human immunodeficiency virus (HIV) type 1-infected adolescents receiving highly active antiretroviral therapy regimens (lamivudine [3TC]/zidovudine [ZDV]/efavirenz [EFV], 3TC/ZDV/nelfinavir [NFV], or other regimens) and studied the relationship of viral dynamics with baseline factors and virological responses. Viral decay rates for 115 evaluable subjects were estimated from a viral dynamic model. Viral dynamics in HIV-1-infected individuals aged 12-22 years were similar to those of HIV-1-infected adults and infants. Individuals who received 3TC/ZDV/EFV had a more rapid phase 1 viral decay rate than those who received 3TC/ZDV/NFV or other regimens. Phase 1 viral decay rates were positively correlated with baseline RNA levels and week 1 virus load reductions. Our findings indicate that the 3TC/ZDV/EFV regimen may be more potent than 3TC/ZDV/NFV or other regimens and that early viral dynamics or week 1 virus load reduction measurements may be useful in evaluating the potency of antiretroviral regimens.
authors.affiliation: Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA. hwu@bst.rochester.edu
authors.forename: Hulin
authors.initials: H
authors.lastname: Wu
authors.forename: Janet
authors.initials: J
authors.lastname: Lathey
authors.forename: Ping
authors.initials: P
authors.lastname: Ruan
authors.forename: Steven D
authors.initials: SD
authors.lastname: Douglas
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Spector
authors.forename: Jane
authors.initials: J
authors.lastname: Lindsey
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hughes
authors.forename: Bret J
authors.initials: BJ
authors.lastname: Rudy
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Flynn
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000209:etiology; D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D044383:Black People; D018791:CD4 Lymphocyte Count; D002648:Child; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000209:etiology; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood* / Q000187:drug effects; D012044:Regression Analysis; D012189:Retrospective Studies; D012309:Risk-Taking; D013997:Time Factors; D014481:United States; D019562:Viral Load; D044465:White People; D001741:Black or African American
chemical_list: D012367:RNA, Viral