title: Angioedema of the lips and tongue induced by angiotensin-converting enzyme inhibitor. A report of two cases.
abstract: The following case reports describe the clinical presentation, diagnosis and management of two patients who attended Liverpool University Dental Hospital with rapidly increasing swelling of the lips and tongue. Both patients were suffering from angioedema and were taking an angiotension-converting enzyme (ACE) inhibitor (ACEI). A provisional diagnosis of ACEI-induced angioedema was made. An intramuscular injection of chlorpheniramine maleate was given to both patients and they were immediately transferred to the local accident and emergency department. These cases illustrate the potential role of the general dental practitioner in the early recognition and management of this potentially life-threatening condition.
authors.affiliation: Liverpool University, Dental Hospital and School of Dentistry, Liverpool, UK.
authors.forename: Helen A
authors.initials: HA
authors.lastname: Stevenson
authors.forename: John C
authors.initials: JC
authors.lastname: Steele
authors.forename: E Anne
authors.initials: EA
authors.lastname: Field
authors.forename: Campbell J
authors.initials: CJ
authors.lastname: Darroch
mesh_terms: D000368:Aged; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D002744:Chlorpheniramine / Q000627:therapeutic use; D004656:Enalapril / Q000009:adverse effects; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D008047:Lip Diseases / Q000139:chemically induced*; D008297:Male; D020913:Perindopril / Q000009:adverse effects; D014060:Tongue Diseases / Q000139:chemically induced*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D006634:Histamine H1 Antagonists; D002744:Chlorpheniramine; D004656:Enalapril; D020913:Perindopril