Fatal arrhythmia following intraoperative continuous hyperthermic peritoneal perfusion chemotherapy.
Continuous hyperthermic peritoneal perfusion chemotherapy (CHPPC) offers a safe alternative to manage peritoneal tumor seeding in advanced cancer patients. A 65-year-old male underwent exploratory laparotomy for advanced gastric cancer with intraabdominal carcinomatosis and massive ascites. Life-threatening dysrrhythmia of ventricular rhythm with a rate of 120 beats/min developed during the performance of intraoperative CHPPC following eradication of the main tumor. With timely cardiopulmonary resuscitation, appropriate fluid replacement, correction of electrolyte imbalance, and cooling of body temperature, the patient regained effective cardiopulmonary circulation without sequela.
Chung
Nien-Chun
NC
Department of Anesthesiology, Kaohsiung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taiwan, R.O.C.
Liu
Yen-Chin
YC
Ye
Xuan-De
XD
Wang
Ying-Ming
YM
Kuo
Mei-Ching
MC
Liu
Kang
K
D000008:Abdominal Neoplasms / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002277:Carcinoma / Q000601:surgery; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007430:Intraoperative Care / Q000009:adverse effects*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D017180:Tachycardia, Ventricular / Q000209:etiology*
D016685:Mitomycin; D002945:Cisplatin