title: Acquisition of high-risk human papillomavirus infections and pap smear abnormalities among women in the New Independent States of the Former Soviet Union.
abstract: The rates of acquisition and the times of incident high-risk (HR) human papillomavirus (HPV) infections and Pap smear abnormalities and their predictive factors were analyzed in women participating in a multicenter screening study in three countries of the New Independent States of the former Soviet Union. The 423 patients were prospectively monitored for a mean of 21.6 months. At the baseline, 118 women were HR HPV DNA negative (Hybrid Capture II assay) and Pap smear negative (group 1), 184 were HPV DNA positive and Pap smear negative (group 2), and 121 were HPV DNA negative and Pap smear positive (group 3). The time to the acquisition of an incident abnormal Pap smear (19.4 months) was significantly longer in group 1 than in group 2 (9.2 months) (P = 0.0001). The times of acquisition of incident HR HPV infection were 16.6 and 11.0 months in group 1 and group 3, respectively (P = 0.006). The monthly rates of acquisition of incident HR HPV infections were very similar in group 1 (1.0%) and group 3 (0.8%), whereas the rate of acquisition of an abnormal Pap smear was significantly higher in group 2 (3.1%) than in group 1 (1.5%) (P = 0.0001). The acquisition of HR HPV infection (but not a positive Pap smear result) was significantly (P = 0.0001) age dependent. The only significant independent (P = 0.001) predictor of the incidence of an abnormal Pap smear result was a high HR HPV load of >20 relative light units/control value (CO) (rate ratio, 2.050; 95% confidence interval, 1.343 to 3.129). Independent predictors of incident HR HPV infection were patient category (a sexually transmitted disease) and ever having been pregnant. The time of acquisition of HR HPV infection was 3 months shorter than that of an abnormal Pap smear. At the baseline the high load of a particular HR HPV type is the single most important predictor of an incident Pap smear abnormality, whereas young age and having a sexually transmitted disease predict incident HR HPV infections.
authors.affiliation: Department of Oral Pathology, Institute of Dentistry, and MediCity Research Laboratory, University of Turku, Turku, Finland. stina.syrjanen@utu.fi
authors.forename: Stina
authors.initials: S
authors.lastname: Syrjänen
authors.forename: Irena
authors.initials: I
authors.lastname: Shabalova
authors.forename: Nicolay
authors.initials: N
authors.lastname: Petrovichev
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kozachenko
authors.forename: Tatjana
authors.initials: T
authors.lastname: Zakharova
authors.forename: Julia
authors.initials: J
authors.lastname: Pajanidi
authors.forename: Jurij
authors.initials: J
authors.lastname: Podistov
authors.forename: Galina
authors.initials: G
authors.lastname: Chemeris
authors.forename: Larisa
authors.initials: L
authors.lastname: Sozaeva
authors.forename: Elena
authors.initials: E
authors.lastname: Lipova
authors.forename: Irena
authors.initials: I
authors.lastname: Tsidaeva
authors.forename: Olga
authors.initials: O
authors.lastname: Ivanchenko
authors.forename: Alla
authors.initials: A
authors.lastname: Pshepurko
authors.forename: Sergej
authors.initials: S
authors.lastname: Zakharenko
authors.forename: Raisa
authors.initials: R
authors.lastname: Nerovjna
authors.forename: Ludmila
authors.initials: L
authors.lastname: Kljukina
authors.forename: Oksana
authors.initials: O
authors.lastname: Erokhina
authors.forename: Marina
authors.initials: M
authors.lastname: Branovskaja
authors.forename: Maritta
authors.initials: M
authors.lastname: Nikitina
authors.forename: Valerija
authors.initials: V
authors.lastname: Grunberga
authors.forename: Alexandr
authors.initials: A
authors.lastname: Grunberg
authors.forename: Anna
authors.initials: A
authors.lastname: Juschenko
authors.forename: Piero
authors.initials: P
authors.lastname: Tosi
authors.forename: Marcella
authors.initials: M
authors.lastname: Cintorino
authors.forename: Rosa
authors.initials: R
authors.lastname: Santopietro
authors.forename: Kari
authors.initials: K
authors.lastname: Syrjänen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology*; D013997:Time Factors; D014586:USSR / Q000453:epidemiology; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral