title: Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise training.
abstract: We assessed the effects of coagulation factor VII (FVII) gene polymorphisms, lipid-related polymorphisms, and exercise training-induced plasma lipoprotein lipid changes on FVII level changes with exercise training in middle- to older-aged men and women. Forty-six healthy sedentary men and women were stabilized on a low-fat diet and then underwent baseline testing, 6 mo of endurance exercise training, and final testing. Plasma FVII-Ag levels decreased with exercise training (106.7 +/- 1.4 vs. 104.2 +/- 1.6%, P = 0.005). There were no significant differences in FVII-Ag changes with exercise training between -323 (0/10 bp)/-401 (G/T) haplotype or -402 (G/A) genotype groups. FVII-Ag changes with training were not correlated with changes in plasma lipoprotein lipids. In linear regression analyses, FVII-Ag changes with training remained significant after adjusting for training-induced plasma lipoprotein lipid changes (P = 0.01). FVII changes with training were associated with apolipoprotein E genotype (P = 0.012); this relationship was still evident after adjusting for training-induced plasma lipoprotein lipid changes (P = 0.047). FVII changes with training also were significantly associated with human ATPase binding cassette-1 genotype (P = 0.018); this relationship persisted after accounting for the effect of the training-induced plasma lipoprotein lipid changes (P = 0.045). We conclude that plasma FVII-Ag changes with exercise training are more closely related to selected lipid-related genotypes than FVII gene promoter variants.
authors.affiliation: Department of Kinesiology, University of Maryland, College Park, MD 20742-2611, USA.
authors.forename: Ioana A
authors.initials: IA
authors.lastname: Ghiu
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: Onanong
authors.initials: O
authors.lastname: Kulaputana
authors.forename: Dana A
authors.initials: DA
authors.lastname: Phares
authors.forename: James M
authors.initials: JM
authors.lastname: Hagberg
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015444:Exercise / Q000502:physiology*; D005167:Factor VII / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D005167:Factor VII