title: Analysis of the information structure of protein sequences: a new method for analyzing the domain organization of proteins.
abstract: The amino acid sequences of gamma-crystallin, Haloalkane Dehalogenase, Phthalate Dioxygenase, Porphobilinogen Deaminase and Myosin Regulatory Domain c-chain were analyzed for their information content. Sites of increased degree of information coordination between residues (IDIC-sites) were identified, and their organization was studied by means of analyzing the information structure of the protein sequences. Relationships between the structural units forming the spatial and informational structure of proteins were demonstrated. Associations of information-coordinated structural elements (IDIC-associations) were mapped onto compact structural domains found in the spatial structures of globular proteins. The proposed method of analyzing the information structure of protein sequences may find applications in the biotechnology and structural chemistry of proteins.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho-Maklaya, 16/10, Moscow, 117997 Russia. alexei_nekrasov@mail.ru
authors.forename: Alexei N
authors.initials: AN
authors.lastname: Nekrasov
mesh_terms: D000595:Amino Acid Sequence; D030562:Databases, Protein; D006867:Hydrolases / Q000737:chemistry; D008958:Models, Molecular; D018994:Myosin Light Chains / Q000737:chemistry; D010105:Oxygenases / Q000737:chemistry; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein / Q000379:methods*; D038222:gamma-Crystallins / Q000737:chemistry
chemical_list: D018994:Myosin Light Chains; D038222:gamma-Crystallins; D010105:Oxygenases; C044732:phthalate dioxygenase; D006867:Hydrolases; C046137:haloalkane dehalogenase