Non-invasive detection of ketosis and its application in refractory epilepsy.
Ketosis is believed to be necessary to the anticonvulsant mechanism of the ketogenic diet; however, the relationship between ketosis and seizure control has not been established. The various analytical methods for the assessment of ketosis are reviewed, and their application in the area of epilepsy and the ketogenic diet is evaluated. The clinical challenges inherent in interpreting measures of ketosis are discussed, as are suggestions for future studies.
Musa-Veloso
K
K
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Room 308, Toronto, Ontario, Canada M5S 3E2. kathy.musa@utoronto.ca
D000096:Acetone / Q000378:metabolism; D000818:Animals; D004827:Epilepsy / Q000378:metabolism*; D006801:Humans; D007659:Ketones / Q000097:blood / Q000652:urine; D007662:Ketosis / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism / Q000517:prevention & control
D007659:Ketones; D000096:Acetone