title: [Hepatitis C virus infection and primary hepatic large B-cell lymphoma: a non-fortuitous association. Case report and review of literature].
abstract: We report a case of hepatitis C virus infection in association with primary hepatic large B-cell non-Hodgkin's lymphoma. Primary hepatic non-Hodgkin's lymphoma is a rare disease. Association of hepatitis C virus infection with primary hepatic B-cell non-hodgkin's lymphoma is probably not fortuitous. Indeed, in case of primary hepatic non-hodgkin's lymphoma' patients are often hepatitis C virus positive. Moreover, several studies have reported a high prevalence of chronic hepatitis C virus infection among patients with B-cell non-Hodgkin's lymphoma whatever the localization of the lymphoma. A recent study found a high rate of remission of a splenic form of lymphoma after treatment of hepatitis C virus infection. Our case report confirms the hypothesis of a key role of hepatitis C virus in the pathogenesis of various forms of B-cell lymphoproliferative disorders and in particular in primary hepatic lymphoma.
authors.affiliation: Service d'hépato-gastroentérologie, Hôpital Saint-Camille, Bry sur Marne. B.Condat@ch-bry.org
authors.forename: Bertrand
authors.initials: B
authors.lastname: Condat
authors.forename: Joëlle
authors.initials: J
authors.lastname: Bonnet
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Hauuy
authors.forename: Véronique
authors.initials: V
authors.lastname: Collot
authors.forename: Alain
authors.initials: A
authors.lastname: Charlier
authors.forename: Laurent
authors.initials: L
authors.lastname: Dugue
authors.forename: Yan
authors.initials: Y
authors.lastname: Ngo
authors.forename: Anouar
authors.initials: A
authors.lastname: Maftouh
authors.forename: Thierry
authors.initials: T
authors.lastname: Diche
authors.forename: Olivia
authors.initials: O
authors.lastname: Bandin
authors.forename: Bernard
authors.initials: B
authors.lastname: Guigui
authors.forename: Bouchra
authors.initials: B
authors.lastname: Asli
authors.forename: Martine
authors.initials: M
authors.lastname: Blazquez
mesh_terms: D000368:Aged; D005260:Female; D016174:Hepacivirus / Q000472:pathogenicity*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000503:physiopathology / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000503:physiopathology / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000503:physiopathology / Q000821:virology*