Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells.
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D017209:Apoptosis; D015153:Blotting, Western; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D016193:G1 Phase; D006657:Histones / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008527:Medulloblastoma / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D009474:Neurons / Q000378:metabolism; D010648:Phenylacetates / Q000494:pharmacology*; D010654:Phenylbutyrates / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D016192:Resting Phase, Cell Cycle; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D006657:Histones; D010648:Phenylacetates; D010654:Phenylbutyrates; D012333:RNA, Messenger; C025136:phenylacetic acid