The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk.
D000328:Adult; D000483:Alleles; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000235:genetics*; D004717:Endometrium / Q000201:enzymology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism; D002393:Estrogens, Catechol; D005260:Female; D020719:Glucuronides / Q000096:biosynthesis; D014453:Glucuronosyltransferase / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013379:Substrate Specificity; D000099148:UGT1A1 Enzyme
D004958:Estradiol; D002393:Estrogens, Catechol; D020719:Glucuronides; D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme; C001390:2-hydroxyestradiol; C014036:4-hydroxyestradiol