Noradrenaline-induced contraction mediated by endothelial COX-1 metabolites in the rat coronary artery.
D000818:Animals; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D003331:Coronary Vessels / Q000187:drug effects*; D051545:Cyclooxygenase 1; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology; D005480:Flurbiprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000493:pharmacokinetics; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000493:pharmacokinetics; D009638:Norepinephrine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D012503:Saponins / Q000008:administration & dosage / Q000493:pharmacokinetics
D016166:Free Radical Scavengers; D007527:Isoenzymes; D008565:Membrane Proteins; D017382:Reactive Oxygen Species; D012503:Saponins; D016718:Arachidonic Acid; D005480:Flurbiprofen; D051545:Cyclooxygenase 1; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat; D019331:NG-Nitroarginine Methyl Ester; D009638:Norepinephrine