Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
D000906:Antibodies / Q000276:immunology; D064007:Ataxia Telangiectasia Mutated Proteins; D002166:Camptothecin / Q000494:pharmacology; D018797:Cell Cycle Proteins; D002460:Cell Line; D004249:DNA Damage; D004261:DNA Replication; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases / Q000145:classification; D010766:Phosphorylation; D010769:Phosphothreonine / Q000276:immunology; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism; D011839:Radiation, Ionizing; D051716:Replication Protein A; D013912:Threonine / Q000378:metabolism*; D025521:Tumor Suppressor Proteins
D000906:Antibodies; D064007:Ataxia Telangiectasia Mutated Proteins; D002166:Camptothecin; D018797:Cell Cycle Proteins; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D005047:Etoposide; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases; D010769:Phosphothreonine; D017346:Protein Serine-Threonine Kinases; D021122:Protein Subunits; D051716:Replication Protein A; D013912:Threonine; D025521:Tumor Suppressor Proteins; C497167:RPA1 protein, human; C576324:ATM protein, human; C497263:PRKDC protein, human