Derivative spectrophotometric and fluorimetric methods for determination of rofecoxib in tablets and in human plasma in presence of its photo-degradation product.
D002138:Calibration; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D006801:Humans; D007202:Indicators and Reagents; D007527:Isoenzymes / Q000378:metabolism; D007783:Lactones / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D008565:Membrane Proteins; D010777:Photochemistry; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D012015:Reference Standards; D015203:Reproducibility of Results; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013450:Sulfones; D013607:Tablets
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007202:Indicators and Reagents; D007527:Isoenzymes; D007783:Lactones; D008565:Membrane Proteins; D012996:Solutions; D013450:Sulfones; D013607:Tablets; C116926:rofecoxib; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases