Stereoselective synthesis and preliminary evaluation of (+)- and (-)-3-methyl-5-carboxy-thien-2-yl-glycine (3-MATIDA): identification of (+)-3-MATIDA as a novel mGluR1 competitive antagonist.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D001667:Binding, Competitive / Q000187:drug effects; D016466:CHO Cells; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007202:Indicators and Reagents; D008968:Molecular Conformation; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology*
C465380:3-methyl-aminothiophene dicarboxylic acid; D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D007202:Indicators and Reagents; D018094:Receptors, Metabotropic Glutamate; D013876:Thiophenes; C104077:metabotropic glutamate receptor type 1; C079694:alpha-methyl-4-carboxyphenylglycine; D005998:Glycine