Subacute toxicity and toxicokinetics of CJ-10882, a type IV phosphodiesterase inhibitor, after 4-week repeated oral administration in dogs.
D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology; D001835:Body Weight / Q000187:drug effects; D003517:Cyclopentanes / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005260:Female; D006834:Hydrazines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D012472:Salivation / Q000187:drug effects; D013950:Thymus Gland / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests; D014839:Vomiting / Q000139:chemically induced
C483181:(E)-((3-cyclopentyloxy-4-methoxyphenyl)methylene)-hydrazinecarboxamide; D003517:Cyclopentanes; D006834:Hydrazines; D010726:Phosphodiesterase Inhibitors