Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth.
D000911:Antibodies, Monoclonal / Q000276:immunology / Q000494:pharmacology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000037:antagonists & inhibitors* / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000037:antagonists & inhibitors / Q000502:physiology; D039302:Integrin alphaVbeta3 / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism*; D019096:Vitronectin / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D018971:Insulin-Like Growth Factor Binding Protein 2; D039302:Integrin alphaVbeta3; D019096:Vitronectin; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II