Direct evidence for increased hydroxyl radicals in angiotensin II-induced cardiac hypertrophy through angiotensin II type 1a receptor.
D000804:Angiotensin II / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D000818:Animals; D001795:Blood Pressure Determination; D006332:Cardiomegaly / Q000139:chemically induced* / Q000378:metabolism; D003497:Cyclic N-Oxides; D004578:Electron Spin Resonance Spectroscopy; D017665:Hydroxyl Radical / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D009589:Nitrogen Oxides; D017382:Reactive Oxygen Species / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1 / Q000187:drug effects*
D003497:Cyclic N-Oxides; D009589:Nitrogen Oxides; D017382:Reactive Oxygen Species; D044140:Receptor, Angiotensin, Type 1; D000804:Angiotensin II; D017665:Hydroxyl Radical; C029217:phenyl-N-tert-butylnitrone