PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats.
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure; D003094:Collagen / Q000378:metabolism; D004562:Electrocardiography; D011345:Fenofibrate / Q000494:pharmacology*; D005355:Fibrosis; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006973:Hypertension / Q000517:prevention & control; D007249:Inflammation / Q000503:physiopathology* / Q000517:prevention & control; D007262:Infusions, Intravenous; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D009206:Myocardium / Q000473:pathology*; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000502:physiology*; D014157:Transcription Factors / Q000187:drug effects / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000378:metabolism; D053773:Transforming Growth Factor beta1
D016328:NF-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; C508962:Tgfb1 protein, rat; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D000804:Angiotensin II; D018799:Intercellular Adhesion Molecule-1; D003094:Collagen; D011345:Fenofibrate