The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology*; D045744:Cell Line, Tumor; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000378:metabolism; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D009369:Neoplasms / Q000378:metabolism; D000068437:Pemetrexed; D011799:Quinazolines / Q000493:pharmacokinetics / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000502:physiology*; D013876:Thiophenes / Q000494:pharmacology; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D005493:Folic Acid Antagonists; D005971:Glutamates; D011799:Quinazolines; D011956:Receptors, Cell Surface; D013876:Thiophenes; C094299:ZD 9331; D000068437:Pemetrexed; D006147:Guanine; D005492:Folic Acid; C068874:raltitrexed