Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3.
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002453:Cell Cycle / Q000502:physiology; D002465:Cell Movement / Q000187:drug effects; D004705:Endocytosis / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000037:antagonists & inhibitors*; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D007249:Inflammation / Q000378:metabolism; D039302:Integrin alphaVbeta3 / Q000502:physiology; D007511:Ischemia / Q000378:metabolism; D008024:Ligands; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D020033:Protein Isoforms / Q000819:agonists / Q000737:chemistry; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D051496:Receptor, Fibroblast Growth Factor, Type 1; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology*; D044244:Receptors, Thromboxane A2, Prostaglandin H2 / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000737:chemistry; D019700:Thrombospondin 1 / Q000378:metabolism / Q000494:pharmacology; D013928:Thromboxane A2 / Q000502:physiology; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D019086:Bridged Bicyclo Compounds, Heterocyclic; D005231:Fatty Acids, Unsaturated; D006834:Hydrazines; D039302:Integrin alphaVbeta3; D008024:Ligands; D020033:Protein Isoforms; D017468:Receptors, Fibroblast Growth Factor; D044244:Receptors, Thromboxane A2, Prostaglandin H2; D019700:Thrombospondin 1; D016159:Tumor Suppressor Protein p53; D016222:Fibroblast Growth Factor 2; C061750:7-(3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo(2.2.1)heptan-2-yl)-5-heptenoic acid; D013928:Thromboxane A2; C045749:SQ 29548; C496348:FGFR1 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051496:Receptor, Fibroblast Growth Factor, Type 1