Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18.
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D016026:Bone Marrow Transplantation / Q000276:immunology; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000502:physiology*; D020868:Gene Silencing; D006131:Growth Inhibitors / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D050856:Interferon Regulatory Factor-1; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018664:Interleukin-12 / Q000502:physiology; D020382:Interleukin-18 / Q000502:physiology; D007694:Killer Cells, Natural / Q000473:pathology; D008231:Lymphopenia / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010750:Phosphoproteins / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017471:Receptors, Interferon / Q000172:deficiency / Q000235:genetics; D050794:STAT1 Transcription Factor; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000473:pathology; D015534:Trans-Activators / Q000502:physiology*; D014162:Transfection; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D000096743:Interferon gamma Receptor
D004268:DNA-Binding Proteins; D006131:Growth Inhibitors; D050856:Interferon Regulatory Factor-1; D007371:Interferon-gamma; D018664:Interleukin-12; D020382:Interleukin-18; D010750:Phosphoproteins; D012333:RNA, Messenger; D017471:Receptors, Interferon; D050794:STAT1 Transcription Factor; D015534:Trans-Activators; D014409:Tumor Necrosis Factor-alpha; D000096743:Interferon gamma Receptor; C494257:IRF1 protein, human; C494258:Irf1 protein, mouse; C494079:STAT1 protein, human; C494080:Stat1 protein, mouse