A perturbation-based method for calculating explicit likelihood of evolutionary co-variance in multiple sequence alignments.
D000465:Algorithms; D003198:Computer Simulation; D019143:Evolution, Molecular; D014644:Genetic Variation; D016013:Likelihood Functions; D008957:Models, Genetic; D015233:Models, Statistical; D012044:Regression Analysis; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*