Phosphatidylinositol 3-kinase/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity.
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002196:Capillaries / Q000166:cytology*; D053148:Caspase 3; D061945:Caspase Inhibitors; D016895:Culture Media, Serum-Free / Q000494:pharmacology; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology*; D005799:Genes, Dominant; D006801:Humans; D020287:In Situ Nick-End Labeling; D051034:Inhibitor of Apoptosis Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis* / Q000235:genetics; D009363:Neoplasm Proteins; D010100:Oxygen / Q000633:toxicity; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt; D044140:Receptor, Angiotensin, Type 1 / Q000172:deficiency / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D012171:Retinal Vessels / Q000166:cytology; D015398:Signal Transduction / Q000187:drug effects; D000077022:Survivin; D013552:Swine
C107489:BIRC5 protein, human; D061945:Caspase Inhibitors; D016895:Culture Media, Serum-Free; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D044140:Receptor, Angiotensin, Type 1; D000077022:Survivin; D000804:Angiotensin II; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; C505407:CASP3 protein, human; C505409:Casp3 protein, mouse; D053148:Caspase 3; D010100:Oxygen