Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
D000284:Administration, Oral; D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D015195:Drug Design; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000097:blood / Q000378:metabolism; D006601:Hexoses / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008958:Models, Molecular; D009919:Orchiectomy; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
C483481:11-deoxy-11-(carboxy(3,4-dichlorophenethyl)amino)-3-O-(4-methyloxazolidin-2-one-3-yl)carbamoyl-5-O-(3'-N-desmethyl-3'-N-cyclopropylmethyl)desosaminyl-6-O-methylerythronolide A 11,12-(cyclic carbamate); D006601:Hexoses; D007987:Gonadotropin-Releasing Hormone; C013889:cladinose; D004917:Erythromycin