Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt.
D017209:Apoptosis; D053148:Caspase 3; D020169:Caspases / Q000009:adverse effects / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D004357:Drug Synergism; D006801:Humans; D007723:Korea; D037102:Lectins / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D014784:Mistletoe / Q000737:chemistry*; D009025:Morpholines / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism* / Q000494:pharmacology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D028321:Plant Preparations / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000737:chemistry; D010940:Plant Proteins / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000737:chemistry; D054790:Ribosome Inactivating Proteins, Type 2; D019098:Telomerase / Q000037:antagonists & inhibitors* / Q000235:genetics; D014118:Toxins, Biological / Q000009:adverse effects / Q000737:chemistry; D015854:Up-Regulation
D053148:Caspase 3; D020169:Caspases; D002867:Chromones; D037102:Lectins; D009025:Morpholines; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010744:Phosphoric Monoester Hydrolases; D010936:Plant Extracts; D028321:Plant Preparations; D010940:Plant Proteins; D054790:Ribosome Inactivating Proteins, Type 2; D019098:Telomerase; D014118:Toxins, Biological; C009674:ribosome inactivating protein, Viscum; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; C505407:CASP3 protein, human