title: Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function.
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects / Q000276:immunology; D017951:Antigen Presentation / Q000187:drug effects / Q000276:immunology; D018106:CD28 Antigens / Q000032:analysis / Q000276:immunology*; D017252:CD3 Complex / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D018920:Coculture Techniques; D017077:Culture Media, Conditioned / Q000494:pharmacology; D003713:Dendritic Cells / Q000187:drug effects / Q000276:immunology; D005434:Flow Cytometry; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D007376:Interleukin-2 / Q000494:pharmacology; D017493:Leukocyte Common Antigens / Q000032:analysis; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000032:analysis; D018123:Receptors, Interleukin / Q000032:analysis; D053701:Receptors, Interleukin-10; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; C515370:CCR7 protein, human; D018106:CD28 Antigens; D017252:CD3 Complex; D016827:CD8 Antigens; D017077:Culture Media, Conditioned; D015395:Histocompatibility Antigens Class I; D007376:Interleukin-2; D016693:Receptors, Antigen, T-Cell, alpha-beta; D054400:Receptors, CCR7; D019707:Receptors, Chemokine; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D014373:Tuberculin; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D016753:Interleukin-10; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D017493:Leukocyte Common Antigens