title: Ligands for the peroxisome proliferator-activated receptor-gamma and the retinoid X receptor exert additive anti-inflammatory effects on experimental autoimmune encephalomyelitis.
mesh_terms: D000077556:Alitretinoin; D000704:Analysis of Variance; D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007114:Immunization / Q000379:methods; D007150:Immunohistochemistry / Q000379:methods; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology; D008024:Ligands; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008822:Mice, Transgenic; D017628:Microglia / Q000166:cytology / Q000187:drug effects; D004676:Myelin Basic Protein; D009569:Nitric Oxide / Q000378:metabolism; D010446:Peptide Fragments / Q000235:genetics; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000096:biosynthesis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D018168:Receptors, Retinoic Acid / Q000819:agonists*; D047488:Retinoid X Receptors; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D014157:Transcription Factors / Q000819:agonists*; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: C477819:15-deoxyprostaglandin J2; D016207:Cytokines; D004338:Drug Combinations; D008024:Ligands; D004676:Myelin Basic Protein; D010446:Peptide Fragments; D012333:RNA, Messenger; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018160:Receptors, Cytoplasmic and Nuclear; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; C109168:T-cell receptor Vbeta 8.2; D014157:Transcription Factors; C405723:myelin basic protein Ac1-11(4Y); D000077556:Alitretinoin; D009569:Nitric Oxide; D014212:Tretinoin; D015230:Prostaglandin D2