Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants.
D000352:Africa, Northern; D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000235:genetics; D000818:Animals; D001665:Binding Sites; D045744:Cell Line, Tumor; D020022:Genetic Predisposition to Disease; D020662:Guanine Nucleotide Exchange Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D008877:Middle East; D016472:Motor Neuron Disease / Q000209:etiology / Q000235:genetics*; D009154:Mutation; D009447:Neuroblastoma / Q000473:pathology; D011485:Protein Binding; D064067:Rho Guanine Nucleotide Exchange Factors; D013482:Superoxide Dismutase / Q000235:genetics* / Q000633:toxicity; D000072105:Superoxide Dismutase-1; D014162:Transfection
C438187:ALS2 protein, human; D020662:Guanine Nucleotide Exchange Factors; D064067:Rho Guanine Nucleotide Exchange Factors; C000606290:SOD1 protein, human; C000606291:Sod1 protein, mouse; D013482:Superoxide Dismutase; D000072105:Superoxide Dismutase-1