Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.
D000595:Amino Acid Sequence; D000818:Animals; D001018:Aortic Diseases / Q000201:enzymology* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000201:enzymology* / Q000503:physiopathology; D019556:COS Cells / Q000201:enzymology; D002522:Chlorocebus aethiops; D054501:Group II Phospholipases A2; D006801:Humans; D006868:Hydrolysis; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D010741:Phospholipases A / Q000235:genetics / Q000378:metabolism*; D054467:Phospholipases A2; D011993:Recombinant Fusion Proteins / Q000502:physiology; D013379:Substrate Specificity
D008077:Lipoproteins, LDL; D011993:Recombinant Fusion Proteins; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2