Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.
D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D032065:Mitragyna / Q000737:chemistry; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D017450:Receptors, Opioid, mu / Q000378:metabolism; D046948:Secologanin Tryptamine Alkaloids / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D013623:Tail
D000701:Analgesics, Opioid; D010936:Plant Extracts; D017450:Receptors, Opioid, mu; D046948:Secologanin Tryptamine Alkaloids; C482678:7-hydroxymitragynine; C001801:mitragynine