Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans.
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D002809:Chondroitin Sulfates / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects / Q000821:virology*; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism*; D006497:Heparan Sulfate / Q000378:metabolism; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D007739:L Cells; D007781:Lactoferrin / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D014759:Viral Envelope Proteins / Q000378:metabolism
D000998:Antiviral Agents; D002809:Chondroitin Sulfates; D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D007781:Lactoferrin; D014759:Viral Envelope Proteins; C038535:glycoprotein gC, herpes simplex virus type 1