Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.
D000818:Animals; D044946:Biflavonoids / Q000494:pharmacology*; D002392:Catechin; D042944:Cholestenone 5 alpha-Reductase / Q000037:antagonists & inhibitors*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005947:Glucose / Q000031:analogs & derivatives*; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D011471:Prostatic Neoplasms / Q000378:metabolism; D051381:Rats; D011944:Receptors, Androgen / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics; D013739:Testosterone / Q000378:metabolism
D044946:Biflavonoids; D011944:Receptors, Androgen; C077197:theaflavin digallate; D013739:Testosterone; D005707:Gallic Acid; D002392:Catechin; D042944:Cholestenone 5 alpha-Reductase; D005947:Glucose