Tumor necrosis factor alpha activates the human plasminogen activator inhibitor-1 gene through a distal nuclear factor kappaB site.
D000818:Animals; D001011:Aorta; D001483:Base Sequence; D001665:Binding Sites; D002417:Cattle; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000235:genetics*; D017395:Plasminogen Activator Inhibitor 1 / Q000096:biosynthesis / Q000235:genetics*; D011401:Promoter Regions, Genetic; D020218:Response Elements; D012689:Sequence Homology, Nucleic Acid; D015533:Transcriptional Activation; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*; D014471:Umbilical Veins
D016328:NF-kappa B; D017395:Plasminogen Activator Inhibitor 1; D014409:Tumor Necrosis Factor-alpha