RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide.
D000362:Agar / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology*; D015153:Blotting, Western; D018955:CD36 Antigens / Q000096:biosynthesis; D020169:Caspases / Q000378:metabolism; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D045744:Cell Line, Tumor; D002470:Cell Survival; D008040:Genetic Linkage; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D008024:Ligands; D008156:Luciferases / Q000378:metabolism; D008297:Male; D051379:Mice; D009101:Multiple Myeloma / Q000473:pathology*; D010087:Oxides / Q000494:pharmacology*; D011471:Prostatic Neoplasms / Q000473:pathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology*; D045162:Thiazolidinediones; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism*; D014162:Transfection; D020298:U937 Cells; D014960:X Chromosome / Q000235:genetics
D000970:Antineoplastic Agents; D001152:Arsenicals; D018955:CD36 Antigens; D008024:Ligands; D010087:Oxides; D018160:Receptors, Cytoplasmic and Nuclear; D013778:Tetrazolium Salts; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; D000362:Agar; D008156:Luciferases; D020169:Caspases; C022616:thiazolyl blue; C115174:netoglitazone; D000077237:Arsenic Trioxide