Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.
D000818:Animals; D001120:Arginine / Q000235:genetics; D001412:Bacillus subtilis / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019556:COS Cells; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002384:Catalysis; D003198:Computer Simulation; D004252:DNA Mutational Analysis; D006801:Humans; D000077146:Irinotecan; D007700:Kinetics; D007930:Leucine / Q000235:genetics / Q000378:metabolism; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D011817:Rabbits; D012694:Serine / Q000378:metabolism; D014783:Viscosity
D001426:Bacterial Proteins; D012694:Serine; D000077146:Irinotecan; D001120:Arginine; C091617:4-nitrobenzyl esterase; D002265:Carboxylic Ester Hydrolases; D007930:Leucine; D002166:Camptothecin