A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters.
D000081:Acetamides / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000517:prevention & control*; D053818:Chymases; D006224:Cricetinae; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D008297:Male; D010196:Pancreatic Elastase / Q000378:metabolism; D011743:Pyrimidines / Q000627:therapeutic use*; D012697:Serine Endopeptidases / Q000187:drug effects / Q000378:metabolism*
D000081:Acetamides; D004791:Enzyme Inhibitors; C437945:NK3201; D011743:Pyrimidines; D012697:Serine Endopeptidases; D010196:Pancreatic Elastase; D053818:Chymases