The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells.
D000208:Acute Disease; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001483:Base Sequence; D018797:Cell Cycle Proteins / Q000235:genetics*; D045744:Cell Line, Tumor; D050762:Cyclin-Dependent Kinase Inhibitor p15; D017353:Gene Deletion; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology; D050835:Interferon Regulatory Factors; D016899:Interferon-beta / Q000494:pharmacology; D007951:Leukemia, Myeloid; D051379:Mice; D008969:Molecular Sequence Data; D022423:Myeloid Cells / Q000502:physiology*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics*; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D000099185:Interferon Regulatory Factor-8; D000099232:Proto-Oncogene Protein Spi-1
D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D050762:Cyclin-Dependent Kinase Inhibitor p15; D050835:Interferon Regulatory Factors; D016899:Interferon-beta; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins; D000099185:Interferon Regulatory Factor-8; D000099232:Proto-Oncogene Protein Spi-1; C493968:Cdkn2b protein, mouse