title: Phosphatidylinositol 3-kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-kappa B signaling pathways are required for B cell antigen receptor-mediated cyclin D2 induction in mature B cells.
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000201:enzymology* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000276:immunology; D056742:Cyclin D2; D016213:Cyclins / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics; D016193:G1 Phase / Q000235:genetics / Q000276:immunology; D020868:Gene Silencing / Q000276:immunology; D051550:I-kappa B Kinase; D020672:I-kappa B Proteins / Q000378:metabolism; D048369:MAP Kinase Kinase 1; D048370:MAP Kinase Kinase 2; D020935:MAP Kinase Signaling System / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D020929:Mitogen-Activated Protein Kinase Kinases / Q000502:physiology*; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology; D019869:Phosphatidylinositol 3-Kinases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D011947:Receptors, Antigen, B-Cell / Q000037:antagonists & inhibitors / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000494:pharmacology; D016160:Retinoblastoma Protein / Q000037:antagonists & inhibitors / Q000378:metabolism; D013154:Spleen / Q000201:enzymology / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D056742:Cyclin D2; D016213:Cyclins; D051550:I-kappa B Kinase; D020672:I-kappa B Proteins; D048369:MAP Kinase Kinase 1; D048370:MAP Kinase Kinase 2; D020929:Mitogen-Activated Protein Kinase Kinases; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B; D010455:Peptides; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D011947:Receptors, Antigen, B-Cell; D011993:Recombinant Fusion Proteins; D016160:Retinoblastoma Protein; C486196:Ccnd2 protein, mouse; C000606204:NFKBIA protein, human; C000606205:Nfkbia protein, mouse; C118258:SN50 peptide; C482128:MAP2K2 protein, human; C496564:Chuk protein, mouse; C496562:Ikbkb protein, mouse; C496566:Ikbke protein, mouse; C482125:MAP2K1 protein, human; C482127:Map2k1 protein, mouse