title: DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.
mesh_terms: D042846:CDC2-CDC28 Kinases / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000378:metabolism; D002478:Cells, Cultured; D051357:Cyclin-Dependent Kinase 2; D050759:Cyclin-Dependent Kinase Inhibitor p21; D004249:DNA Damage / Q000235:genetics*; D004261:DNA Replication; D015536:Down-Regulation / Q000528:radiation effects; D016193:G1 Phase; D006657:Histones / Q000235:genetics*; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D011839:Radiation, Ionizing; D014158:Transcription, Genetic / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: C493956:CDKN1A protein, human; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D006657:Histones; C101693:NPAT protein, human; D009687:Nuclear Proteins; D016159:Tumor Suppressor Protein p53; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2