IL-4-mediated inhibition of IFN-gamma production by CD4+ T cells proceeds by several developmentally regulated mechanisms.
D000818:Animals; D000906:Antibodies / Q000378:metabolism / Q000494:pharmacology; D018106:CD28 Antigens / Q000276:immunology / Q000378:metabolism; D017252:CD3 Complex / Q000276:immunology / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D050990:GATA3 Transcription Factor; D015870:Gene Expression / Q000235:genetics; D007371:Interferon-gamma / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D051379:Mice; D050800:STAT6 Transcription Factor; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation
D000906:Antibodies; D018106:CD28 Antigens; D017252:CD3 Complex; D004268:DNA-Binding Proteins; D050990:GATA3 Transcription Factor; C494748:Gata3 protein, mouse; D050800:STAT6 Transcription Factor; C494100:Stat6 protein, mouse; D015534:Trans-Activators; D015847:Interleukin-4; D007371:Interferon-gamma