A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.
D019943:Amino Acid Substitution; D000818:Animals; D001412:Bacillus subtilis / Q000201:enzymology; D001426:Bacterial Proteins; D001665:Binding Sites; D002384:Catalysis; D017124:Conserved Sequence; D006418:Heme / Q000737:chemistry*; D007501:Iron / Q000737:chemistry; D007532:Isoleucine; D007700:Kinetics; D051379:Mice; D008956:Models, Chemical; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000737:chemistry* / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D014633:Valine
D001426:Bacterial Proteins; D007532:Isoleucine; D009569:Nitric Oxide; D006418:Heme; D007501:Iron; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D014633:Valine