Astrocytic regulation of NMDA receptor subunit composition modulates the toxicity of prion peptide PrP106-126.
D000818:Animals; D000831:Animals, Newborn; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism*; D002450:Cell Communication / Q000502:physiology; D002478:Cells, Cultured; D018920:Coculture Techniques; D003300:Copper / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D018698:Glutamic Acid / Q000378:metabolism; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism / Q000633:toxicity*; D017096:Prion Diseases / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D011328:Prions / Q000378:metabolism / Q000633:toxicity*; D021122:Protein Subunits / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D010446:Peptide Fragments; D011328:Prions; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate; C082632:prion protein (106-126); D016718:Arachidonic Acid; D018698:Glutamic Acid; D003300:Copper