Downregulation of Ca(2+) and Mg(2+) transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia.
D000818:Animals; D064026:Calbindins; D002118:Calcium / Q000652:urine*; D015220:Calcium Channels / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology; D015536:Down-Regulation / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D008274:Magnesium / Q000097:blood* / Q000502:physiology*; D008297:Male; D008659:Metabolic Diseases / Q000139:chemically induced* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D050916:TRPV Cation Channels; D016559:Tacrolimus / Q000494:pharmacology*
D064026:Calbindins; D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D007166:Immunosuppressive Agents; D064030:S100 Calcium Binding Protein G; D050916:TRPV Cation Channels; C492241:TRPV5 protein, rat; D008274:Magnesium; D002118:Calcium; D016559:Tacrolimus