Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP.
D051722:ADAM Proteins; D000071121:ADAMTS4 Protein; D000818:Animals; D002356:Cartilage / Q000737:chemistry*; D002358:Cartilage, Articular / Q000378:metabolism; D002417:Cattle; D019902:Chondrocytes / Q000502:physiology*; D016000:Cluster Analysis; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000096:biosynthesis; D000242:Cyclic AMP / Q000378:metabolism; D054746:Cyclic AMP-Dependent Protein Kinase Type II; D017868:Cyclic AMP-Dependent Protein Kinases / Q000096:biosynthesis; D051546:Cyclooxygenase 2; D004533:Egtazic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D005786:Gene Expression Regulation; D007527:Isoenzymes / Q000096:biosynthesis; D007700:Kinetics; D053509:Matrix Metalloproteinase 13; D019278:Matrix Metalloproteinase 3 / Q000096:biosynthesis; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis; D008666:Metalloendopeptidases / Q000096:biosynthesis; D008957:Models, Genetic; D011348:Procollagen N-Endopeptidase; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis; D012313:RNA / Q000737:chemistry; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction; D013314:Stress, Mechanical; D013718:Tensile Strength; D013997:Time Factors; D014158:Transcription, Genetic; D015854:Up-Regulation
D007527:Isoenzymes; D012333:RNA, Messenger; C070379:1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester; D004533:Egtazic Acid; D012313:RNA; D003094:Collagen; D000242:Cyclic AMP; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D054746:Cyclic AMP-Dependent Protein Kinase Type II; D017868:Cyclic AMP-Dependent Protein Kinases; D051722:ADAM Proteins; D017364:Collagenases; D053509:Matrix Metalloproteinase 13; D008666:Metalloendopeptidases; D011348:Procollagen N-Endopeptidase; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9; D000071121:ADAMTS4 Protein