title: Structural determinants for the intracellular degradation of human thymidylate synthase.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002460:Cell Line; D006224:Cricetinae; D004790:Enzyme Induction / Q000235:genetics; D004795:Enzyme Stability / Q000235:genetics; D006801:Humans; D007424:Intracellular Fluid / Q000201:enzymology*; D008024:Ligands; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D010446:Peptide Fragments / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D010447:Peptide Hydrolases / Q000737:chemistry; D046988:Proteasome Endopeptidase Complex; D011487:Protein Conformation; D017434:Protein Structure, Tertiary / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D013940:Thymidylate Synthase / Q000096:biosynthesis / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D044764:Ubiquitin-Activating Enzymes / Q000502:physiology
chemical_list: D008024:Ligands; D010446:Peptide Fragments; D025801:Ubiquitin; D013940:Thymidylate Synthase; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; D044764:Ubiquitin-Activating Enzymes