Remnant lipoprotein particles induce apoptosis in endothelial cells by NAD(P)H oxidase-mediated production of superoxide and cytokines via lectin-like oxidized low-density lipoprotein receptor-1 activation: prevention by cilostazol.
D000328:Adult; D017209:Apoptosis / Q000187:drug effects*; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects; D053298:Chylomicron Remnants; D002914:Chylomicrons / Q000494:pharmacology; D000077407:Cilostazol; D016207:Cytokines / Q000096:biosynthesis*; D042783:Endothelial Cells / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D019833:Genistein / Q000494:pharmacology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics; D008074:Lipoproteins / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D026901:Membrane Transport Proteins / Q000096:biosynthesis / Q000235:genetics; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000096:biosynthesis / Q000235:genetics; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D010750:Phosphoproteins / Q000096:biosynthesis / Q000235:genetics; D011973:Receptors, LDL / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D013481:Superoxides / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics; D020830:rac1 GTP-Binding Protein / Q000378:metabolism
D053298:Chylomicron Remnants; D002914:Chylomicrons; D016207:Cytokines; D004791:Enzyme Inhibitors; D007375:Interleukin-1; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D010750:Phosphoproteins; D011973:Receptors, LDL; D013777:Tetrazoles; D014409:Tumor Necrosis Factor-alpha; C099252:oxidized low density lipoprotein; D013481:Superoxides; D019833:Genistein; C056558:CYBB protein, human; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; C086986:CYBA protein, human; D009252:NADPH Dehydrogenase; D020830:rac1 GTP-Binding Protein; D000077407:Cilostazol