title: Codon-optimized genes that enable increased heterologous expression in mammalian cells and elicit efficient immune responses in mice after vaccination of naked DNA.
mesh_terms: D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015153:Blotting, Western; D019556:COS Cells; D002460:Cell Line; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D019295:Computational Biology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015870:Gene Expression; D015683:Gene Products, gag / Q000235:genetics / Q000276:immunology; D005814:Genes, Viral; D015483:HIV Antibodies / Q000096:biosynthesis; D015497:HIV-1 / Q000235:genetics / Q000276:immunology; D006367:HeLa Cells; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D011498:Protein Precursors / Q000235:genetics / Q000276:immunology; D014162:Transfection; D019444:Vaccines, DNA / Q000235:genetics* / Q000494:pharmacology
chemical_list: D003062:Codon; D015683:Gene Products, gag; D015483:HIV Antibodies; D007132:Immunoglobulin Isotypes; D011498:Protein Precursors; D019444:Vaccines, DNA; C059767:p55 gag precursor protein, Human immunodeficiency virus 1