Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
D051017:Apoptosis Regulatory Proteins; D001343:Autophagy / Q000187:drug effects*; D000071186:Beclin-1; D045744:Cell Line, Tumor; D002518:Ceramides / Q000494:pharmacology* / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors; D006801:Humans; D008565:Membrane Proteins; D008854:Microscopy, Electron; D014176:Protein Biosynthesis; D017346:Protein Serine-Threonine Kinases; D011506:Proteins; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors*; D051057:Proto-Oncogene Proteins c-akt; D013629:Tamoxifen / Q000494:pharmacology; D015854:Up-Regulation; D014617:Vacuoles
D051017:Apoptosis Regulatory Proteins; C491997:BECN1 protein, human; D000071186:Beclin-1; D002518:Ceramides; D004791:Enzyme Inhibitors; D008565:Membrane Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D013629:Tamoxifen; D005964:Glucosyltransferases; C023246:ceramide glucosyltransferase; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt