Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death.
D021581:Active Transport, Cell Nucleus / Q000187:drug effects / Q000502:physiology; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D053477:Apoptotic Protease-Activating Factor 1; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D003593:Cytoplasm / Q000378:metabolism; D018390:Gene Targeting; D017930:Genes, Reporter; D006624:Hippocampus / Q000166:cytology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016328:NF-kappa B / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism*; D010446:Peptide Fragments / Q000633:toxicity*; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics* / Q000378:metabolism; D047888:Receptors, Tumor Necrosis Factor, Type I; D015398:Signal Transduction / Q000502:physiology*; D014162:Transfection; D015854:Up-Regulation / Q000187:drug effects
C506592:APAF1 protein, human; D016229:Amyloid beta-Peptides; D015703:Antigens, CD; C506593:Apaf1 protein, mouse; D053477:Apoptotic Protease-Activating Factor 1; D016328:NF-kappa B; D010446:Peptide Fragments; D011506:Proteins; D012333:RNA, Messenger; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; C078592:amyloid beta-protein (1-40)