Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling.
D000818:Animals; D002460:Cell Line; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D002867:Chromones / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051379:Mice; D009025:Morpholines / Q000494:pharmacology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D010766:Phosphorylation; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011106:Polyisoprenyl Phosphates / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000494:pharmacology; D012717:Sesquiterpenes; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014118:Toxins, Biological / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology; D020744:rac GTP-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
D002867:Chromones; D004791:Enzyme Inhibitors; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D009025:Morpholines; D010982:Platelet-Derived Growth Factor; D011106:Polyisoprenyl Phosphates; D011518:Proto-Oncogene Proteins; D011994:Recombinant Proteins; D012717:Sesquiterpenes; D014118:Toxins, Biological; D042461:Vascular Endothelial Growth Factor A; C012258:mevastatin; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D000077340:Fluvastatin; D007334:Insulin-Like Growth Factor I; C004808:farnesyl pyrophosphate; D008148:Lovastatin; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; C002963:geranylgeranyl pyrophosphate