Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm.
D000704:Analysis of Variance; D000818:Animals; D001692:Biological Transport; D015153:Blotting, Western / Q000379:methods; D002545:Brain Ischemia / Q000517:prevention & control*; D002452:Cell Count / Q000379:methods; D016923:Cell Death / Q000187:drug effects; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects; D016572:Cyclosporine / Q000627:therapeutic use*; D045304:Cytochromes c / Q000378:metabolism*; D003593:Cytoplasm / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004622:Embryo, Mammalian; D005849:Gerbillinae; D018698:Glutamic Acid / Q000633:toxicity; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D066298:In Vitro Techniques; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D018613:Microscopy, Confocal / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D019311:Staurosporine / Q000633:toxicity; D016559:Tacrolimus / Q000494:pharmacology; D013997:Time Factors; D014404:Tubulin / Q000378:metabolism
D007166:Immunosuppressive Agents; D014404:Tubulin; C462941:beta3 tubulin, mouse; D018698:Glutamic Acid; D016572:Cyclosporine; D045304:Cytochromes c; D006861:Hydrogen Peroxide; D019311:Staurosporine; D016559:Tacrolimus