title: Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates.
mesh_terms: D000595:Amino Acid Sequence; D000838:Anions; D001665:Binding Sites; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D004583:Electrons; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D006860:Hydrogen Bonding; D019877:Hydroxymethyl and Formyl Transferases / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry*; D009709:Nucleotide Deaminases / Q000737:chemistry*; D011485:Protein Binding; D011487:Protein Conformation; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity; D013449:Sulfonamides / Q000494:pharmacology; D013763:Tetrahydrofolates / Q000494:pharmacology
chemical_list: D000838:Anions; C486470:BW 1540; C486471:BW 2315; D004791:Enzyme Inhibitors; D009097:Multienzyme Complexes; D013449:Sulfonamides; D013763:Tetrahydrofolates; C113120:inosine monophosphate synthase; D019877:Hydroxymethyl and Formyl Transferases; D009709:Nucleotide Deaminases