Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression.
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001011:Aorta; D002417:Cattle; D051242:Caveolin 1; D022461:Caveolins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D002460:Cell Line; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D018450:Disease Progression; D004298:Dopamine / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D006029:Glycosuria / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology; D051379:Mice; D016688:Mice, Inbred NOD; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D010656:Phenylephrine / Q000494:pharmacology; D011972:Receptor, Insulin / Q000737:chemistry; D018340:Receptors, Adrenergic, alpha-1 / Q000096:biosynthesis / Q000172:deficiency* / Q000187:drug effects / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000096:biosynthesis / Q000172:deficiency* / Q000187:drug effects / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology; D014664:Vasodilation / Q000502:physiology
D000318:Adrenergic beta-Agonists; C495540:CAV1 protein, human; C495541:Cav1 protein, mouse; D051242:Caveolin 1; D022461:Caveolins; D018340:Receptors, Adrenergic, alpha-1; D018343:Receptors, Adrenergic, beta-2; D011993:Recombinant Fusion Proteins; D010656:Phenylephrine; D009569:Nitric Oxide; D012701:Serotonin; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496315:Nos3 protein, mouse; D011972:Receptor, Insulin; D007545:Isoproterenol; D019331:NG-Nitroarginine Methyl Ester; D004298:Dopamine