Nitric oxide-induced apoptosis is mediated by Bax/Bcl-2 gene expression, transition of cytochrome c, and activation of caspase-3 in rat vascular smooth muscle cells.
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D015153:Blotting, Western; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D002452:Cell Count; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D045304:Cytochromes c / Q000235:genetics*; D003593:Cytoplasm / Q000201:enzymology; D004789:Enzyme Activation / Q000502:physiology; D005434:Flow Cytometry; D015870:Gene Expression / Q000235:genetics / Q000502:physiology*; D019254:Genes, bcl-2 / Q000235:genetics*; D020287:In Situ Nick-End Labeling; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D009569:Nitric Oxide / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D051381:Rats; D017207:Rats, Sprague-Dawley; D013778:Tetrazolium Salts; D013844:Thiazoles; D051028:bcl-2-Associated X Protein
C494828:Bax protein, rat; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D013778:Tetrazolium Salts; D013844:Thiazoles; D051028:bcl-2-Associated X Protein; D009569:Nitric Oxide; D045304:Cytochromes c; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; C022616:thiazolyl blue