title: p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells.
mesh_terms: D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D053453:Caspase 9; D020169:Caspases / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor; D004249:DNA Damage; D004305:Dose-Response Relationship, Drug; D016193:G1 Phase / Q000187:drug effects / Q000235:genetics; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D008545:Melanoma / Q000201:enzymology* / Q000235:genetics / Q000473:pathology*; D009285:Naphthoquinones / Q000494:pharmacology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D006131:Growth Inhibitors; D009285:Naphthoquinones; D016159:Tumor Suppressor Protein p53; C016101:shikonin; C506433:CASP9 protein, human; D053453:Caspase 9; D020169:Caspases