title: CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
mesh_terms: D000818:Animals; D016227:Benzoquinones; D015153:Blotting, Western; D019556:COS Cells; D002460:Cell Line; D045744:Cell Line, Tumor; D004268:DNA-Binding Proteins / Q000378:metabolism; D003902:Detergents / Q000494:pharmacology; D029721:Drosophila Proteins / Q000502:physiology*; D005822:Genetic Vectors; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D000076249:Heat Shock Transcription Factors; D006801:Humans; D007150:Immunohistochemistry; D047468:Immunoprecipitation; D007763:Lac Operon; D047029:Lactams, Macrocyclic; D051379:Mice; D008957:Models, Genetic; D018832:Molecular Chaperones / Q000737:chemistry; D009154:Mutation; D009687:Nuclear Proteins / Q000502:physiology*; D011485:Protein Binding; D011809:Quinones / Q000494:pharmacology; D013347:Subcellular Fractions / Q000378:metabolism; D014157:Transcription Factors; D014162:Transfection; D019076:Transgenes; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016227:Benzoquinones; C108740:Chi protein, Drosophila; D004268:DNA-Binding Proteins; D003902:Detergents; D029721:Drosophila Proteins; D018840:HSP70 Heat-Shock Proteins; D000076249:Heat Shock Transcription Factors; D047029:Lactams, Macrocyclic; D018832:Molecular Chaperones; D009687:Nuclear Proteins; D011809:Quinones; D014157:Transcription Factors; D025801:Ubiquitin; D016875:tau Proteins; D044767:Ubiquitin-Protein Ligases; C001277:geldanamycin