Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D017209:Apoptosis; D053148:Caspase 3; D053453:Caspase 9; D020169:Caspases / Q000378:metabolism; D016923:Cell Death; D045744:Cell Line, Tumor; D002470:Cell Survival; D002843:Chromatin / Q000378:metabolism; D004396:Coloring Agents / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D045304:Cytochromes c / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D042963:Electron Transport Complex II / Q000037:antagonists & inhibitors*; D004789:Enzyme Activation; D006801:Humans; D000071058:Huntingtin Protein; D015151:Immunoblotting; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008564:Membrane Potentials; D051379:Mice; D008822:Mice, Transgenic; D008928:Mitochondria / Q000378:metabolism; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000473:pathology; D009574:Nitro Compounds; D009687:Nuclear Proteins / Q000235:genetics*; D010455:Peptides / Q000378:metabolism; D011422:Propionates / Q000494:pharmacology; D012402:Rotenone / Q000494:pharmacology; D012430:Ruthenium Red / Q000494:pharmacology; D013347:Subcellular Fractions; D013997:Time Factors; D014118:Toxins, Biological; D014475:Uncoupling Agents / Q000494:pharmacology
D000959:Antihypertensive Agents; D002843:Chromatin; D004396:Coloring Agents; C086055:HTT protein, human; C506812:Htt protein, mouse; D000071058:Huntingtin Protein; D007166:Immunosuppressive Agents; D009419:Nerve Tissue Proteins; D009574:Nitro Compounds; D009687:Nuclear Proteins; D010455:Peptides; D011422:Propionates; D014118:Toxins, Biological; D014475:Uncoupling Agents; D012402:Rotenone; D012430:Ruthenium Red; C097188:polyglutamine; D016572:Cyclosporine; D045304:Cytochromes c; D007770:L-Lactate Dehydrogenase; D042963:Electron Transport Complex II; C505407:CASP3 protein, human; C506433:CASP9 protein, human; C505409:Casp3 protein, mouse; C506434:Casp9 protein, mouse; D053148:Caspase 3; D053453:Caspase 9; D020169:Caspases; C015392:3-nitropropionic acid