Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo.
D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D002460:Cell Line; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D044464:Receptor, PAR-2 / Q000819:agonists*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D044464:Receptor, PAR-2; C109968:seryl-leucyl-isoleucyl--glycyl-lysyl-valine; C112356:seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide; C016977:amastatin; D000626:Aminopeptidases