The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange.
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004789:Enzyme Activation; D005260:Female; D022001:Focal Adhesions / Q000187:drug effects*; D006801:Humans; D051379:Mice; D009361:Neoplasm Invasiveness / Q000517:prevention & control*; D012964:Sodium / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers / Q000187:drug effects*; D022502:Stress Fibers / Q000187:drug effects*; D041701:Swiss 3T3 Cells; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D000470:Alkaloids; D000970:Antineoplastic Agents; D017923:Sodium-Hydrogen Exchangers; C409085:motuporamine C; D012964:Sodium; D020741:rho GTP-Binding Proteins