The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis.
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology*; D016466:CHO Cells; D019556:COS Cells; D054804:Cathelicidins; D002455:Cell Division; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D006224:Cricetinae; D004247:DNA / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004705:Endocytosis; D005434:Flow Cytometry; D018014:Gene Transfer Techniques; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D021962:Membrane Microdomains / Q000737:chemistry; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry; D010957:Plasmids / Q000378:metabolism; D011509:Proteoglycans / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors
D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D010455:Peptides; D011509:Proteoglycans; D004247:DNA; D008156:Luciferases