title: Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.
mesh_terms: D000494:Allosteric Regulation; D019943:Amino Acid Substitution; D001549:Benzamides / Q000737:chemistry; D001665:Binding Sites; D002460:Cell Line; D003514:Cyclohexylamines / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009281:Naphthalenes / Q000737:chemistry; D017434:Protein Structure, Tertiary; D044169:Receptors, Calcium-Sensing / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D014162:Transfection
chemical_list: D001549:Benzamides; D003514:Cyclohexylamines; D008565:Membrane Proteins; C482333:N(1)-(4-chlorobenzoyl)-N(2)-(1-(1-naphthyl)ethyl)-1,2-diaminocyclohexane; C436740:N-(2-hydroxy-3-(2-cyano-3-chlorophenoxy)propyl)-1,1-dimethyl-2-(2-nephthyl)ethylamine; D009281:Naphthalenes; D044169:Receptors, Calcium-Sensing