Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins.
D000818:Animals; D019703:Calcineurin / Q000502:physiology*; D020013:Calcium Signaling; D002478:Cells, Cultured; D017635:Clonal Anergy; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics; D056827:Endosomal Sorting Complexes Required for Transport; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D000075702:Nedd4 Ubiquitin Protein Ligases; D051966:Phospholipase C gamma; D011493:Protein Kinase C / Q000378:metabolism; D000074121:Protein Kinase C-theta; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D010738:Type C Phospholipases / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism; D015854:Up-Regulation; D000099177:Tsg101 Protein
D019703:Calcineurin; D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D007527:Isoenzymes; D000075702:Nedd4 Ubiquitin Protein Ligases; D051966:Phospholipase C gamma; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta; D012333:RNA, Messenger; D014157:Transcription Factors; D010738:Type C Phospholipases; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins; D000099177:Tsg101 Protein; C471637:Itch protein, mouse; C000618461:Nedd4l protein, mouse; C489593:Prkcq protein, mouse