The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer.
D000144:Acids, Acyclic / Q000494:pharmacology*; D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology; D001665:Binding Sites; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics*; D002994:Clofibrate / Q000494:pharmacology; D004268:DNA-Binding Proteins; D019281:Dimerization; D015248:Gemfibrozil / Q000494:pharmacology; D005786:Gene Expression Regulation; D051537:Hepatocyte Nuclear Factor 1; D051538:Hepatocyte Nuclear Factor 1-alpha; D051539:Hepatocyte Nuclear Factor 1-beta; D006801:Humans; D006888:Hydroxycholesterols / Q000494:pharmacology; D008024:Ligands; D000071518:Liver X Receptors; D009687:Nuclear Proteins; D057093:Orphan Nuclear Receptors; D011401:Promoter Regions, Genetic; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid; D020218:Response Elements; D014157:Transcription Factors / Q000378:metabolism*
D000144:Acids, Acyclic; D004268:DNA-Binding Proteins; C496487:HNF1A protein, human; C496495:HNF1B protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; C496489:Hnf1a protein, rat; D006888:Hydroxycholesterols; D008024:Ligands; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; C000605215:Nr1h3 protein, rat; D009687:Nuclear Proteins; D057093:Orphan Nuclear Receptors; D011743:Pyrimidines; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D051537:Hepatocyte Nuclear Factor 1; D051539:Hepatocyte Nuclear Factor 1-beta; C007997:25-hydroxycholesterol; C006253:pirinixic acid; D002790:Cholesterol 7-alpha-Hydroxylase; D002994:Clofibrate; D015248:Gemfibrozil; D001629:Bezafibrate