title: An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing.
mesh_terms: D017398:Alternative Splicing; D020816:Amino Acid Motifs; D001483:Base Sequence; D001665:Binding Sites; D002460:Cell Line; D003432:Cross-Linking Reagents / Q000494:pharmacology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D004252:DNA Mutational Analysis; D004305:Dose-Response Relationship, Drug; D005091:Exons; D017353:Gene Deletion; D020868:Gene Silencing; D005822:Genetic Vectors; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D009154:Mutation; D010957:Plasmids / Q000378:metabolism; D039102:Poly(A)-Binding Proteins; D038941:Polypyrimidine Tract-Binding Protein / Q000737:chemistry*; D011233:Precipitin Tests; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D012342:RNA, Small Nuclear / Q000378:metabolism; D016601:RNA-Binding Proteins; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D000074019:T-Cell Intracellular Antigen-1; D015533:Transcriptional Activation; D014162:Transfection; D014466:Ultraviolet Rays
chemical_list: C505032:CFTR protein, human; D003432:Cross-Linking Reagents; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D011743:Pyrimidines; D012342:RNA, Small Nuclear; D016601:RNA-Binding Proteins; D017412:Ribonucleoprotein, U1 Small Nuclear; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; C405483:U1 small nuclear RNA; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D038941:Polypyrimidine Tract-Binding Protein