Exogenous attenuation of p21(Waf1/Cip1) decreases mesangial cell hypertrophy as a result of hyperglycemia and IGF-1.
D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000096:biosynthesis* / Q000187:drug effects; D005920:Glomerular Mesangium / Q000473:pathology*; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics* / Q000473:pathology; D006984:Hypertrophy; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D020319:Oligodeoxyribonucleotides, Antisense / Q000494:pharmacology
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D020319:Oligodeoxyribonucleotides, Antisense; D007334:Insulin-Like Growth Factor I