title: Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins.
mesh_terms: D018797:Cell Cycle Proteins; D002460:Cell Line; D016195:G2 Phase; D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000648:ultrastructure*; D008938:Mitosis; D015739:Nocodazole / Q000494:pharmacology; D020411:Oligonucleotide Array Sequence Analysis; D009856:Oncogene Proteins, Viral / Q000502:physiology*; D050725:Papillomavirus E7 Proteins; D011123:Polyploidy; D011494:Protein Kinases / Q000096:biosynthesis; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D016160:Retinoblastoma Protein / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D015854:Up-Regulation; D000097869:Polo-Like Kinase 1
chemical_list: D018797:Cell Cycle Proteins; D015739:Nocodazole; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D000097869:Polo-Like Kinase 1; C068651:E6 protein, Human papillomavirus type 16; C059731:oncogene protein E7, Human papillomavirus type 16