Somatostatin inhibits glutamate release from mouse cerebrocortical nerve endings through presynaptic sst2 receptors linked to the adenylyl cyclase-protein kinase A pathway.
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D017729:Presynaptic Terminals / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism*; D017661:Receptors, Presynaptic / Q000819:agonists / Q000502:physiology*; D017481:Receptors, Somatostatin / Q000819:agonists / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013004:Somatostatin / Q000494:pharmacology*
D000067956:Adenylyl Cyclase Inhibitors; D004791:Enzyme Inhibitors; D017661:Receptors, Presynaptic; D017481:Receptors, Somatostatin; D018698:Glutamic Acid; D013004:Somatostatin; C093733:somatostatin receptor 2; D017868:Cyclic AMP-Dependent Protein Kinases; D000262:Adenylyl Cyclases