Synthesis, characterization, and preliminary in vivo tests of new poly(ethylene glycol) conjugates of the antitumor agent 10-amino-7-ethylcamptothecin.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D002401:Cathepsin B / Q000737:chemistry; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006868:Hydrolysis; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
C483494:10-amino-7-ethylcamptothecin; D000970:Antineoplastic Agents; D009842:Oligopeptides; D011355:Prodrugs; C483495:monomethoxypolyethylene glycol-carbonyl-glycyl-leucyl-phenylalanyl-glycyl-10-amino-7-ethylcamptothecin; D011092:Polyethylene Glycols; D002401:Cathepsin B; D002166:Camptothecin