Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR.
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002942:Circular Dichroism; D003300:Copper / Q000494:pharmacology*; D004351:Drug Resistance; D019286:Endopeptidase K / Q000494:pharmacology; D020022:Genetic Predisposition to Disease; D007113:Immunity, Innate; D008345:Manganese / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D009532:Nickel / Q000494:pharmacology; D010446:Peptide Fragments / Q000276:immunology; D011110:Polymorphism, Genetic; D018621:PrPC Proteins / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology; D011489:Protein Denaturation; D017510:Protein Folding; D017433:Protein Structure, Secondary / Q000187:drug effects; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000187:drug effects / Q000276:immunology; D012608:Scrapie / Q000235:genetics; D012756:Sheep / Q000235:genetics*; D012757:Sheep Diseases / Q000235:genetics; D013696:Temperature
D000911:Antibodies, Monoclonal; D010446:Peptide Fragments; D018621:PrPC Proteins; D011993:Recombinant Fusion Proteins; D008345:Manganese; D003300:Copper; D009532:Nickel; D019286:Endopeptidase K