Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D019540:Area Under Curve; D001632:Bibenzyls / Q000494:pharmacology*; D002138:Calibration; D045744:Cell Line, Tumor; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D004396:Coloring Agents / Q000494:pharmacology; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D013058:Mass Spectrometry; D051379:Mice; D008956:Models, Chemical; D010766:Phosphorylation; D011355:Prodrugs; D013267:Stilbenes / Q000494:pharmacology*; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D013997:Time Factors
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D004396:Coloring Agents; D011355:Prodrugs; D013267:Stilbenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C063690:combretastatin A-1; C040105:combretastatin; C022616:thiazolyl blue; C058728:fosbretabulin