Synthesis and structure-activity relationships of 4,10-dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine derivatives: highly potent and selective AMPA receptor antagonists with in vivo activity.
D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D005849:Gerbillinae; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology; D011719:Pyrazines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
C491785:4,10-dihydro-4-oxo-4H-imidazo(1,2-a)indeno(1,2-e)pyrazine; D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D007093:Imidazoles; D018696:Neuroprotective Agents; D011719:Pyrazines; C473371:RPR 117824; D018091:Receptors, AMPA