Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002352:Carrier Proteins / Q000737:chemistry*; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016899:Interferon-beta / Q000737:chemistry* / Q000378:metabolism; D007700:Kinetics; D008024:Ligands; D008297:Male; D008565:Membrane Proteins; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000737:chemistry*; D013816:Thermodynamics; D013997:Time Factors
D000998:Antiviral Agents; D002352:Carrier Proteins; C508033:IFNAR2 protein, human; D008024:Ligands; D008565:Membrane Proteins; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta; D016899:Interferon-beta