Neointimal smooth muscle cells display a proinflammatory phenotype resulting in increased leukocyte recruitment mediated by P-selectin and chemokines.
D000818:Animals; D001013:Aorta, Thoracic / Q000293:injuries; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D003251:Constriction, Pathologic; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D004730:Endothelium, Vascular / Q000293:injuries; D005786:Gene Expression Regulation; D006937:Hypercholesterolemia / Q000378:metabolism; D020672:I-kappa B Proteins / Q000502:physiology; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D039041:Integrin alpha4beta1 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000166:cytology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000502:physiology*; D019007:P-Selectin / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D023063:Receptors, Interleukin-8B / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000502:physiology; D012008:Recurrence; D012212:Rheology; D016176:T-Lymphocyte Subsets / Q000166:cytology
D001057:Apolipoproteins E; D054428:Chemokine CX3CL1; D020523:Chemokines, CX3C; C515539:Cx3cl1 protein, mouse; C515540:Cx3cl1 protein, rat; D016207:Cytokines; D020672:I-kappa B Proteins; D039041:Integrin alpha4beta1; D008565:Membrane Proteins; D016328:NF-kappa B; C000606205:Nfkbia protein, mouse; C000606206:Nfkbia protein, rat; D019007:P-Selectin; D023063:Receptors, Interleukin-8B; D011993:Recombinant Fusion Proteins; D000072000:NF-KappaB Inhibitor alpha