title: NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven.
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000477:Alkylating Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007659:Ketones / Q000737:chemistry; D007700:Kinetics; D013058:Mass Spectrometry; D008956:Models, Chemical; D000081223:Polycyclic Sesquiterpenes; D012680:Sensitivity and Specificity; D012717:Sesquiterpenes / Q000494:pharmacology*; D013997:Time Factors; D014162:Transfection
chemical_list: D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D007659:Ketones; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C052673:illudin M; C102714:irofulven; D000429:Alcohol Oxidoreductases; C082646:leukotriene B4 12-hydroxydehydrogenase; C008105:illudin S; D005978:Glutathione