Isoflavones extracted from Sophorae fructus upregulate IGF-I and TGF-beta and inhibit osteoclastogenesis in rat bone marrow cells.
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000502:physiology; D016723:Bone Remodeling / Q000187:drug effects* / Q000502:physiology; D002118:Calcium / Q000737:chemistry / Q000494:pharmacology; D002356:Cartilage / Q000737:chemistry; D002460:Cell Line; D019587:Dietary Supplements; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D019833:Genistein / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012754:Sharks; D029909:Sophora / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry; D014020:Tissue Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D015854:Up-Regulation / Q000235:genetics*
D007529:Isoflavones; D010936:Plant Extracts; D014020:Tissue Extracts; D016212:Transforming Growth Factor beta; D009569:Nitric Oxide; D004958:Estradiol; D007334:Insulin-Like Growth Factor I; D019833:Genistein; D002118:Calcium