General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels.
D000818:Animals; D016466:CHO Cells / Q000187:drug effects; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D002460:Cell Line / Q000187:drug effects; D018118:Chloride Channels / Q000502:physiology*; D006224:Cricetinae; D000242:Cyclic AMP / Q000032:analysis / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003550:Cystic Fibrosis; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism*; D004847:Epithelial Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D000442:Octanols / Q000494:pharmacology*; D018408:Patch-Clamp Techniques
C505032:CFTR protein, human; D018118:Chloride Channels; D000442:Octanols; C093349:cystic fibrosis transmembrane conductance regulator delta F508; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D002118:Calcium