RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11alpha signaling.
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D016466:CHO Cells; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology; D006224:Cricetinae; D017931:DNA Primers; D018076:DNA, Complementary / Q000235:genetics; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000502:physiology*; D006801:Humans; D051379:Mice; D018613:Microscopy, Confocal; D011487:Protein Conformation; D020710:RGS Proteins / Q000235:genetics / Q000378:metabolism*; D043643:Receptor, Muscarinic M1 / Q000737:chemistry* / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D017384:Sequence Deletion; D015398:Signal Transduction; D018411:Spodoptera; D014162:Transfection
D017931:DNA Primers; D018076:DNA, Complementary; D020710:RGS Proteins; D043643:Receptor, Muscarinic M1; D011993:Recombinant Fusion Proteins; C105345:Rgs2 protein, mouse; D043802:GTP-Binding Protein alpha Subunits, Gq-G11