A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord.
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D001369:Axons / Q000187:drug effects* / Q000637:transplantation; D002478:Cells, Cultured; D002921:Cicatrix / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D021881:DNA, Catalytic / Q000378:metabolism* / Q000494:pharmacology; D004058:Diffusion; D004195:Disease Models, Animal; D005727:Ganglia, Spinal / Q000166:cytology / Q000637:transplantation*; D006025:Glycosaminoglycans / Q000378:metabolism*; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology; D010430:Pentosyltransferases / Q000235:genetics; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D016212:Transforming Growth Factor beta / Q000494:pharmacology; D016896:Treatment Outcome; D000097608:UDP Xylose-Protein Xylosyltransferase
D021881:DNA, Catalytic; D006025:Glycosaminoglycans; D010430:Pentosyltransferases; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D000097608:UDP Xylose-Protein Xylosyltransferase