Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice.
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D001835:Body Weight; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004452:Echocardiography; D006133:Growth Substances / Q000378:metabolism; D006333:Heart Failure / Q000235:genetics; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000096:biosynthesis* / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D005810:Multigene Family; D009206:Myocardium / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D013312:Stress, Physiological; D013997:Time Factors; D015854:Up-Regulation
D016207:Cytokines; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C065700:myotrophin; D012260:Ribonucleases