A unique model system for tumor progression in GBM comprising two developed human neuro-epithelial cell lines with differential transforming potential and coexpressing neuronal and glial markers.
D000368:Aged; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D018929:Cell Culture Techniques / Q000379:methods*; D045744:Cell Line, Tumor / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D066246:ErbB Receptors / Q000378:metabolism; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D007621:Karyotyping; D008297:Male; D018613:Microscopy, Confocal; D009361:Neoplasm Invasiveness / Q000473:pathology; D009419:Nerve Tissue Proteins; D064231:Nestin; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D009418:S100 Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014404:Tubulin / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D000099190:MAP-Kinase-Activated Kinase 2
D066246:ErbB Receptors; D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D064231:Nestin; D017346:Protein Serine-Threonine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D009418:S100 Proteins; D014404:Tubulin; D014746:Vimentin; D000099190:MAP-Kinase-Activated Kinase 2; C577484:NES protein, human; C110294:S100A1 protein