Alzheimer's beta-secretase cleaves a glycosyltransferase as a physiological substrate.
D000544:Alzheimer Disease / Q000201:enzymology* / Q000209:etiology; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D010450:Endopeptidases; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D012799:Sialyltransferases / Q000378:metabolism*; D013379:Substrate Specificity; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D016564:Amyloid beta-Protein Precursor; D012799:Sialyltransferases; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase