Pharmacodynamic-pharmacokinetic profiles of metformin hydrochloride from a mucoadhesive formulation of a polysaccharide with antidiabetic property in streptozotocin-induced diabetic rat models.
D000268:Adhesiveness; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D046508:Culture Techniques; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy*; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D005079:Excipients / Q000493:pharmacokinetics / Q000494:pharmacology; D005690:Galactose / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D007413:Intestinal Mucosa / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008687:Metformin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D053149:Plant Gums; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D013718:Tensile Strength / Q000187:drug effects; D014014:Tissue Adhesives / Q000493:pharmacokinetics / Q000494:pharmacology; D016896:Treatment Outcome
D001786:Blood Glucose; D005079:Excipients; D007004:Hypoglycemic Agents; D053149:Plant Gums; D014014:Tissue Adhesives; C491916:detarium gum; D013311:Streptozocin; D008687:Metformin; D005690:Galactose