title: Specific structural requirements for the inhibitory effect of thapsigargin on the Ca2+ ATPase SERCA.
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry; D000251:Adenosine Triphosphatases / Q000737:chemistry; D000818:Animals; D001665:Binding Sites; D015153:Blotting, Western; D019556:COS Cells; D000252:Calcium-Transporting ATPases / Q000737:chemistry* / Q000378:metabolism; D002645:Chickens; D004252:DNA Mutational Analysis; D018076:DNA, Complementary / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D019286:Endopeptidase K / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006873:Hydroquinones / Q000494:pharmacology; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D018482:Muscle, Skeletal / Q000378:metabolism; D009154:Mutation; D010649:Phenylalanine / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D013379:Substrate Specificity; D019284:Thapsigargin / Q000494:pharmacology*; D014162:Transfection; D019076:Transgenes
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018076:DNA, Complementary; D004791:Enzyme Inhibitors; D006873:Hydroquinones; D008051:Lipid Bilayers; C019359:2,5-di-tert-butylhydroquinone; D010649:Phenylalanine; D019284:Thapsigargin; D019286:Endopeptidase K; D000251:Adenosine Triphosphatases; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases