title: The Na+/H+ exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation.
mesh_terms: D000143:Acids / Q000494:pharmacology; D000818:Animals; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000166:cytology / Q000378:metabolism* / Q000648:ultrastructure; D000242:Cyclic AMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000008:administration & dosage; D007425:Intracellular Membranes / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D008854:Microscopy, Electron; D008871:Microvilli / Q000378:metabolism; D009994:Osmolar Concentration; D012333:RNA, Messenger / Q000378:metabolism; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers / Q000235:genetics / Q000378:metabolism*; D013450:Sulfones / Q000008:administration & dosage; D015854:Up-Regulation
chemical_list: D000143:Acids; D002712:Chlorides; D006146:Guanidines; D012333:RNA, Messenger; C513111:Slc9a2 protein, mouse; C000613386:Slc9a3 protein, mouse; D000074083:Sodium-Hydrogen Exchanger 3; D017923:Sodium-Hydrogen Exchangers; D013450:Sulfones; C069139:growth factor-activatable Na-H exchanger NHE-1; C093373:cariporide; D000242:Cyclic AMP