Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.
D051702:Activating Transcription Factor 6; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D015153:Blotting, Western; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006023:Glycoproteins / Q000737:chemistry; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D009841:Oligonucleotides / Q000737:chemistry; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D017354:Point Mutation; D043484:Proprotein Convertases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D011485:Protein Binding; D011498:Protein Precursors / Q000737:chemistry; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D012697:Serine Endopeptidases / Q000737:chemistry*; D015843:Serpins / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D051782:Sterol Regulatory Element Binding Protein 2; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism; D014162:Transfection; D014764:Viral Proteins / Q000737:chemistry*; D000515:alpha 1-Antitrypsin / Q000737:chemistry
C497111:ATF6 protein, human; D051702:Activating Transcription Factor 6; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D006023:Glycoproteins; D009841:Oligonucleotides; D010982:Platelet-Derived Growth Factor; D011498:Protein Precursors; C497390:SREBF2 protein, human; D015843:Serpins; D051782:Sterol Regulatory Element Binding Protein 2; D014157:Transcription Factors; D014764:Viral Proteins; D000515:alpha 1-Antitrypsin; C113421:alpha 1-antitrypsin Portland; C075278:platelet-derived growth factor A; D012967:Sodium Dodecyl Sulfate; D043484:Proprotein Convertases; D012697:Serine Endopeptidases; C115575:membrane-bound transcription factor peptidase, site 1