LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1.
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D002154:Calpain / Q000037:antagonists & inhibitors; D002460:Cell Line; D004268:DNA-Binding Proteins; D004789:Enzyme Activation / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis* / Q000494:pharmacology; D019787:Linoleic Acid; D000071518:Liver X Receptors; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D057093:Orphan Nuclear Receptors; D010168:Palmitates / Q000494:pharmacology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D013230:Stearoyl-CoA Desaturase / Q000378:metabolism*
D064286:ATP Binding Cassette Transporter 1; D018528:ATP-Binding Cassette Transporters; D004268:DNA-Binding Proteins; D005231:Fatty Acids, Unsaturated; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D010168:Palmitates; D018160:Receptors, Cytoplasmic and Nuclear; D019787:Linoleic Acid; D013230:Stearoyl-CoA Desaturase; D002154:Calpain