Mutations of hydrophobic residues in the N-terminal domain of troponin C affect calcium binding and exchange with the troponin C-troponin I96-148 complex and muscle force production.
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000737:chemistry* / Q000378:metabolism; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000378:metabolism; D007700:Kinetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D018485:Muscle Fibers, Skeletal / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009154:Mutation; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D016658:Psoas Muscles / Q000378:metabolism; D011817:Rabbits; D015398:Signal Transduction; D013050:Spectrometry, Fluorescence; D013696:Temperature; D013997:Time Factors; D019209:Troponin C / Q000737:chemistry*; D019210:Troponin I / Q000737:chemistry*
D010455:Peptides; D019209:Troponin C; D019210:Troponin I; D002118:Calcium