Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.
D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002452:Cell Count / Q000379:methods; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004622:Embryo, Mammalian; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004852:Epoxy Compounds; D005260:Female; D007150:Immunohistochemistry / Q000379:methods; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology; D008070:Lipopolysaccharides / Q000009:adverse effects; D008297:Male; D008636:Mesencephalon / Q000166:cytology; D017628:Microglia / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011247:Pregnancy; D051381:Rats; D014316:Tritium / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D004852:Epoxy Compounds; D008070:Lipopolysaccharides; D009573:Nitrites; D010616:Phenanthrenes; D014409:Tumor Necrosis Factor-alpha; D014316:Tritium; C001899:triptolide; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine