title: Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D002490:Central Nervous System / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D005684:Gait / Q000502:physiology; D020143:Gangliosidoses, GM2 / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics / Q000502:physiology; D011597:Psychomotor Performance; D013661:Tay-Sachs Disease / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D054820:beta-Hexosaminidase alpha Chain / Q000235:genetics* / Q000502:physiology
chemical_list: C518253:HEXA protein, human; D054820:beta-Hexosaminidase alpha Chain