Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness.
D000818:Animals; D019070:Cell Lineage / Q000502:physiology; D015870:Gene Expression; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D015851:Interleukin-7 / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008822:Mice, Transgenic; D022423:Myeloid Cells / Q000166:cytology*; D020411:Oligonucleotide Array Sequence Analysis; D020395:Receptors, Interleukin-7 / Q000235:genetics*
D015851:Interleukin-7; D020395:Receptors, Interleukin-7