The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces.
D001665:Binding Sites / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D000229:Dependovirus / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D011485:Protein Binding / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D013379:Substrate Specificity; D014764:Viral Proteins / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics*
D004268:DNA-Binding Proteins; D014764:Viral Proteins; C068734:rep proteins, Adeno-associated virus 2; D004720:Endonucleases