The metabolism of pyrazoloacridine (NSC 366140) by cytochromes p450 and flavin monooxygenase in human liver microsomes.
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002384:Catalysis; D002455:Cell Division; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D018076:DNA, Complementary / Q000378:metabolism; D019075:Electrophoresis, Capillary; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D008956:Models, Chemical; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism*; D020033:Protein Isoforms; D011720:Pyrazoles / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013997:Time Factors; D014466:Ultraviolet Rays
D000166:Acridines; D000970:Antineoplastic Agents; D018076:DNA, Complementary; D020033:Protein Isoforms; D011720:Pyrazoles; D011994:Recombinant Proteins; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; C020066:dimethylaniline monooxygenase (N-oxide forming); C104464:CYP3A protein, human; D019388:Cytochrome P-450 CYP1A2; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; C064541:NSC 366140; D010100:Oxygen