title: Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D000242:Cyclic AMP / Q000378:metabolism; D000077270:Exenatide; D005786:Gene Expression Regulation; D005934:Glucagon / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D052216:Glucagon-Like Peptide 1; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D008715:Methionine / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D011498:Protein Precursors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D018027:Receptors, Glucagon / Q000819:agonists* / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D017384:Sequence Deletion / Q000235:genetics; D014443:Tyrosine / Q000235:genetics / Q000378:metabolism*; D014688:Venoms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology
chemical_list: C000593833:GLP1R protein, human; C000593835:Glp1r protein, rat; D000067757:Glucagon-Like Peptide-1 Receptor; D008024:Ligands; D010446:Peptide Fragments; D010455:Peptides; D011498:Protein Precursors; D018027:Receptors, Glucagon; D014688:Venoms; D014443:Tyrosine; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D000077270:Exenatide; D008715:Methionine; D000242:Cyclic AMP