Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D016227:Benzoquinones; D003546:Cysteine Endopeptidases / Q000502:physiology; D006801:Humans; D018796:Immunoconjugates / Q000493:pharmacokinetics*; D047029:Lactams, Macrocyclic; D051379:Mice; D009097:Multienzyme Complexes / Q000502:physiology; D041681:NIH 3T3 Cells; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D046988:Proteasome Endopeptidase Complex; D011809:Quinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D014018:Tissue Distribution; D014183:Transplantation, Heterologous; D000068878:Trastuzumab
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D016227:Benzoquinones; D003546:Cysteine Endopeptidases; D018796:Immunoconjugates; D047029:Lactams, Macrocyclic; D009097:Multienzyme Complexes; D046988:Proteasome Endopeptidase Complex; D011809:Quinones; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; C001277:geldanamycin