RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D015153:Blotting, Western; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D015536:Down-Regulation; D004789:Enzyme Activation; D017353:Gene Deletion; D005822:Genetic Vectors; D020662:Guanine Nucleotide Exchange Factors; D006160:Guanosine Triphosphate / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D008156:Luciferases / Q000378:metabolism; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009154:Mutation; D016328:NF-kappa B / Q000378:metabolism; D011419:Propidium / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D012190:Retroviridae / Q000235:genetics; D015398:Signal Transduction; D014357:Trypsin / Q000494:pharmacology; D051020:bcl-X Protein; D018631:ras Proteins / Q000378:metabolism
C494812:Bcl2l1 protein, mouse; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; D007075:Immunoglobulin M; D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2; C112278:Rasgrp1 protein, mouse; D051020:bcl-X Protein; D011419:Propidium; D006160:Guanosine Triphosphate; D008156:Luciferases; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases; D014357:Trypsin; D018631:ras Proteins