Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma.
D000953:Antigens, Protozoan / Q000378:metabolism*; D001665:Binding Sites; D014408:Biomarkers, Tumor; D019938:Cyclin D1 / Q000096:biosynthesis; D018450:Disease Progression; D017353:Gene Deletion; D017930:Genes, Reporter; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D009687:Nuclear Proteins / Q000096:biosynthesis; D010957:Plasmids / Q000378:metabolism; D011379:Prognosis; D011401:Promoter Regions, Genetic; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis; D051736:Proto-Oncogene Proteins c-mdm2; D034802:RNA-Binding Protein EWS / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000378:metabolism*; D016329:Sp1 Transcription Factor / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
D000953:Antigens, Protozoan; D014408:Biomarkers, Tumor; D019938:Cyclin D1; D008156:Luciferases; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D051736:Proto-Oncogene Proteins c-mdm2; D034802:RNA-Binding Protein EWS; D018719:Erb-b2 Receptor Tyrosine Kinases; D016329:Sp1 Transcription Factor; D042461:Vascular Endothelial Growth Factor A; C061194:Eimeria tenella sporozoite antigen; C497206:MDM2 protein, human