Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.
D037361:Adenylate Cyclase Toxin / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001886:Bordetella pertussis / Q000235:genetics / Q000276:immunology*; D002454:Cell Differentiation / Q000187:drug effects; D003001:Cloning, Molecular; D016207:Cytokines / Q000096:biosynthesis; D003713:Dendritic Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D004357:Drug Synergism; D005260:Female; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000096:biosynthesis; D066298:In Vitro Techniques; D016753:Interleukin-10 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000008:administration & dosage* / Q000276:immunology; D008562:Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011956:Receptors, Cell Surface / Q000172:deficiency / Q000235:genetics; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D037361:Adenylate Cyclase Toxin; D000276:Adjuvants, Immunologic; D016207:Cytokines; D007074:Immunoglobulin G; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D016753:Interleukin-10