Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation.
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism; D016466:CHO Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D019556:COS Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002460:Cell Line; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004789:Enzyme Activation / Q000235:genetics / Q000502:physiology; D004815:Epidermal Growth Factor / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D020935:MAP Kinase Signaling System / Q000235:genetics* / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000502:physiology*; D016297:Mutagenesis, Site-Directed / Q000235:genetics / Q000502:physiology; D009154:Mutation / Q000235:genetics / Q000502:physiology*; D009634:Noonan Syndrome / Q000201:enzymology*; D010750:Phosphoproteins / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D054648:Protein Phosphatase 2; D020836:Protein Structure, Quaternary / Q000235:genetics / Q000502:physiology; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D054593:SH2 Domain-Containing Protein Tyrosine Phosphatases; D018909:src Homology Domains / Q000235:genetics / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D000936:Antigen-Antibody Complex; C098587:GAB1 protein, human; D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D004815:Epidermal Growth Factor; D020928:Mitogen-Activated Protein Kinases; D054648:Protein Phosphatase 2; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D017027:Protein Tyrosine Phosphatases; D054593:SH2 Domain-Containing Protein Tyrosine Phosphatases