Phe393 mutants of cytochrome P450 BM3 with modified heme redox potentials have altered heme vinyl and propionate conformations.
D019943:Amino Acid Substitution / Q000235:genetics*; D001410:Bacillus megaterium / Q000201:enzymology / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry* / Q000235:genetics*; D005290:Ferric Compounds / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry; D006418:Heme / Q000737:chemistry* / Q000235:genetics; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000235:genetics; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000235:genetics*; D009251:NADPH-Ferrihemoprotein Reductase; D010084:Oxidation-Reduction; D010649:Phenylalanine / Q000235:genetics*; D011422:Propionates / Q000737:chemistry*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary / Q000235:genetics; D013059:Spectrum Analysis, Raman; D013379:Substrate Specificity / Q000235:genetics; D014364:Tryptophan / Q000235:genetics; D014443:Tyrosine / Q000235:genetics; D014753:Vinyl Compounds / Q000737:chemistry*
D001426:Bacterial Proteins; D005290:Ferric Compounds; D005296:Ferrous Compounds; D007506:Iron-Sulfur Proteins; D011422:Propionates; D014753:Vinyl Compounds; D014443:Tyrosine; D006418:Heme; D010649:Phenylalanine; D014364:Tryptophan; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase; C052423:flavocytochrome P450 BM3 monoxygenases; C029658:propionic acid