Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D048429:Cell Size; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004268:DNA-Binding Proteins; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D041681:NIH 3T3 Cells; D010766:Phosphorylation; D014176:Protein Biosynthesis; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism*; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication / Q000502:physiology*
D004268:DNA-Binding Proteins; D015852:Eukaryotic Initiation Factor-2; D046911:Macromolecular Substances; D021122:Protein Subunits; D019098:Telomerase