Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2alpha kinase.
D000222:Adaptation, Physiological / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006367:HeLa Cells / Q000166:cytology; D018869:Heat-Shock Response; D006358:Hot Temperature; D006801:Humans; D020014:K562 Cells / Q000166:cytology; D007854:Lead / Q000633:toxicity*; D019892:eIF-2 Kinase / Q000378:metabolism*
D007854:Lead; D019892:eIF-2 Kinase