An approach for cloning biosynthetic genes of 2-deoxystreptamine-containing aminocyclitol antibiotics: isolation of a biosynthetic gene cluster of tobramycin from Streptomyces tenebrarius.
D000595:Amino Acid Sequence; D000617:Aminoglycosides / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D003001:Cloning, Molecular; D015195:Drug Design; D020869:Gene Expression Profiling / Q000379:methods*; D006595:Hexosamines / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008847:Micromonospora / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D013302:Streptomyces / Q000235:genetics* / Q000378:metabolism; D014031:Tobramycin / Q000737:chemistry / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006595:Hexosamines; D011994:Recombinant Proteins; C007265:2-deoxystreptamine; D014031:Tobramycin