ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D002843:Chromatin / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000494:pharmacology*; D004195:Disease Models, Animal; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic; D011495:Histone-Lysine N-Methyltransferase / Q000494:pharmacology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000503:physiopathology; D051379:Mice; D051788:Myeloid-Lymphoid Leukemia Protein; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000503:physiopathology; D011519:Proto-Oncogenes; D014157:Transcription Factors; D016335:Zinc Fingers
D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C497422:KMT2A protein, human; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; C497423:Kmt2a protein, mouse; C479519:TRR protein, Drosophila