title: Loss of PKR activity in chronic lymphocytic leukemia.
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000378:metabolism; D051997:ADP-ribosyl Cyclase 1; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D015536:Down-Regulation; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D017353:Gene Deletion; D050956:HSP40 Heat-Shock Proteins; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins; D010766:Phosphorylation / Q000187:drug effects; D011070:Poly I-C; D012330:RNA, Double-Stranded / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000494:pharmacology; D012097:Repressor Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D019892:eIF-2 Kinase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; C494651:DNAJC3 protein, human; D050956:HSP40 Heat-Shock Proteins; D008562:Membrane Glycoproteins; C104647:PRKRA protein, human; D012330:RNA, Double-Stranded; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53; D019892:eIF-2 Kinase; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1; D011070:Poly I-C