title: A comment on COMET: how to interpret a positive trial?
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D002227:Carbazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D000077261:Carvedilol; D004305:Dose-Response Relationship, Drug; D005060:Europe / Q000453:epidemiology; D006333:Heart Failure / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008790:Metoprolol / Q000008:administration & dosage / Q000627:therapeutic use*; D015337:Multicenter Studies as Topic; D011412:Propanolamines / Q000008:administration & dosage / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D018342:Receptors, Adrenergic, beta-1 / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D018342:Receptors, Adrenergic, beta-1; D000077261:Carvedilol; D008790:Metoprolol