title: Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.
mesh_terms: D000328:Adult; D000368:Aged; D005165:Factor V / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D011486:Protein C / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000378:metabolism; D012307:Risk Factors; D013917:Thrombin / Q000096:biosynthesis / Q000378:metabolism; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics*
chemical_list: D011486:Protein C; D011956:Receptors, Cell Surface; C095381:factor V Leiden; C083864:factor V receptor, human; D005165:Factor V; D013917:Thrombin