Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D001665:Binding Sites; D019013:CD40 Antigens / Q000378:metabolism*; D018929:Cell Culture Techniques; D002460:Cell Line; D003564:Cytidine Deaminase / Q000096:biosynthesis / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000378:metabolism; D024202:Electrophoretic Mobility Shift Assay; D004790:Enzyme Induction; D006801:Humans; D015847:Interleukin-4 / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000187:drug effects / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D050800:STAT6 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism*; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D019013:CD40 Antigens; D004268:DNA-Binding Proteins; D016328:NF-kappa B; D012333:RNA, Messenger; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; C494100:Stat6 protein, mouse; D015534:Trans-Activators; D015847:Interleukin-4; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase