Topical application of a protein kinase C inhibitor reduces skin and hair pigmentation.
D000818:Animals; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000078404:Epidermal Cells; D005260:Female; D006168:Guinea Pigs; D006200:Hair Color / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008301:Maleimides / Q000494:pharmacology*; D008543:Melanins / Q000378:metabolism; D008544:Melanocytes / Q000166:cytology / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018613:Microscopy, Confocal; D014442:Monophenol Monooxygenase / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D064546:Protein Kinase C beta; D012880:Skin Pigmentation / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D008543:Melanins; D014442:Monophenol Monooxygenase; D011493:Protein Kinase C; D064546:Protein Kinase C beta; C088060:bisindolylmaleimide