Positive selection focuses the VH12 B-cell repertoire towards a single B1 specificity with survival function.
D000818:Animals; D000918:Antibody Specificity; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D002470:Cell Survival; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D005803:Genes, Immunoglobulin; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D007147:Immunoglobulin Light Chains / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007135:Immunoglobulin Variable Region / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region