title: Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
mesh_terms: D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D019008:Drug Resistance, Neoplasm; D001330:Electronic Data Processing; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D015723:Gene Library; D006801:Humans; D007621:Karyotyping / Q000379:methods*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D009362:Neoplasm Metastasis; D016019:Survival Analysis; D013940:Thymidylate Synthase / Q000235:genetics*; D013997:Time Factors
chemical_list: D004273:DNA, Neoplasm; D013940:Thymidylate Synthase; D005472:Fluorouracil