Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D008274:Magnesium / Q000737:chemistry; D051379:Mice; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry; D034741:RNA, Small Interfering / Q000378:metabolism; D016914:Ribonuclease H / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D013997:Time Factors
D016376:Oligonucleotides, Antisense; D010455:Peptides; D034741:RNA, Small Interfering; D004247:DNA; C091139:ribonuclease HII; D016914:Ribonuclease H; C078856:ribonuclease HI; D008274:Magnesium