Combined treatment of cisplatin and overexpression of caspase-activated deoxyribonuclease (CAD) promotes apoptosis in vitro and in vivo.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D019470:Biolistics; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D002478:Cells, Cultured; D002945:Cisplatin / Q000494:pharmacology*; D003131:Combined Modality Therapy; D003851:Deoxyribonucleases / Q000235:genetics* / Q000378:metabolism; D005347:Fibroblasts / Q000201:enzymology / Q000648:ultrastructure; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006258:Head and Neck Neoplasms / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D014162:Transfection
D000970:Antineoplastic Agents; D003851:Deoxyribonucleases; C109663:caspase-activated deoxyribonuclease; D002945:Cisplatin