title: Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor.
mesh_terms: D017209:Apoptosis; D001578:Benzopyrans / Q000494:pharmacology; D020013:Calcium Signaling; D045304:Cytochromes c / Q000187:drug effects / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000502:physiology; D018922:HL-60 Cells; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology; D008564:Membrane Potentials; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology; D009570:Nitriles / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D051028:bcl-2-Associated X Protein
chemical_list: C494826:BAX protein, human; D001578:Benzopyrans; D009570:Nitriles; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D051028:bcl-2-Associated X Protein; C456800:ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate; D045304:Cytochromes c