Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene.
D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000235:genetics; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000502:physiology / Q000528:radiation effects; D016158:Genes, p53 / Q000235:genetics* / Q000528:radiation effects; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D009374:Neoplasms, Experimental / Q000235:genetics; D015533:Transcriptional Activation; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D014466:Ultraviolet Rays
D016159:Tumor Suppressor Protein p53; D004247:DNA