Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1).
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D002545:Brain Ischemia / Q000097:blood* / Q000209:etiology; D016022:Case-Control Studies; D015550:Cell Degranulation; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D044463:Receptor, PAR-1 / Q000378:metabolism*; D020521:Stroke / Q000097:blood* / Q000209:etiology; D013917:Thrombin / Q000494:pharmacology*
D015415:Biomarkers; D044463:Receptor, PAR-1; D013917:Thrombin