Imexon-induced apoptosis in multiple myeloma tumor cells is caspase-8 dependent.
D000080242:8-Hydroxy-2'-Deoxyguanosine; D017304:Annexin A5 / Q000494:pharmacology; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D017209:Apoptosis; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005434:Flow Cytometry; D005978:Glutathione / Q000378:metabolism; D006588:Hexanones / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000473:pathology*; D010084:Oxidation-Reduction; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D017382:Reactive Oxygen Species; D013997:Time Factors; D019014:fas Receptor / Q000378:metabolism
D017304:Annexin A5; D018931:Antineoplastic Agents, Hormonal; D004791:Enzyme Inhibitors; D006588:Hexanones; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D019014:fas Receptor; C014919:4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one; D003907:Dexamethasone; D000080242:8-Hydroxy-2'-Deoxyguanosine; C505407:CASP3 protein, human; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases; D003849:Deoxyguanosine; D005978:Glutathione