title: Opening of the mitochondrial permeability transition pore induces reactive oxygen species production at the level of the respiratory chain complex I.
mesh_terms: D000818:Animals; D016923:Cell Death; D004305:Dose-Response Relationship, Drug; D042967:Electron Transport Complex I / Q000378:metabolism; D004583:Electrons; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000494:pharmacology; D007425:Intracellular Membranes / Q000378:metabolism; D007473:Ion Channels / Q000737:chemistry*; D008928:Mitochondria / Q000473:pathology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D008956:Models, Chemical; D009243:NAD / Q000737:chemistry / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D010539:Permeability; D011487:Protein Conformation; D011725:Pyridines / Q000737:chemistry; D051381:Rats; D017382:Reactive Oxygen Species; D012402:Rotenone / Q000494:pharmacology; D013997:Time Factors
chemical_list: D007473:Ion Channels; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D011725:Pyridines; D017382:Reactive Oxygen Species; D012402:Rotenone; D009243:NAD; D006861:Hydrogen Peroxide; D042967:Electron Transport Complex I; D010100:Oxygen