p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
D048948:14-3-3 Proteins; D000818:Animals; D001665:Binding Sites; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D008868:Microtubule Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D010766:Phosphorylation; D025941:Protein Interaction Mapping; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D021381:Protein Transport; D064067:Rho Guanine Nucleotide Exchange Factors; D014162:Transfection; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D054462:p21-Activated Kinases
D048948:14-3-3 Proteins; C577356:ARHGEF2 protein, human; D020662:Guanine Nucleotide Exchange Factors; D008868:Microtubule Proteins; D064067:Rho Guanine Nucleotide Exchange Factors; D014446:Tyrosine 3-Monooxygenase; C515903:PAK1 protein, human; D017346:Protein Serine-Threonine Kinases; D054462:p21-Activated Kinases