Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.
D000111:Acetylcysteine / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology*; D000069059:Atorvastatin; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D016922:Cellular Senescence / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects*; D004272:DNA, Mitochondrial / Q000032:analysis; D004268:DNA-Binding Proteins; D003864:Depression, Chemical; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006538:Heptanoic Acids / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D021381:Protein Transport / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism*; D019061:src-Family Kinases / Q000037:antagonists & inhibitors / Q000502:physiology
C412373:AG 1879; D000975:Antioxidants; D004272:DNA, Mitochondrial; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D006538:Heptanoic Acids; D011743:Pyrimidines; D011758:Pyrroles; D017382:Reactive Oxygen Species; D000069059:Atorvastatin; D006861:Hydrogen Peroxide; D019061:src-Family Kinases; C509186:TERT protein, human; D019098:Telomerase; D000111:Acetylcysteine