Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition.
D000818:Animals; D017209:Apoptosis; D051033:Apoptosis Inducing Factor; D001253:Astrocytes / Q000166:cytology* / Q000201:enzymology / Q000648:ultrastructure; D005420:Flavoproteins / Q000378:metabolism; D007425:Intracellular Membranes / Q000502:physiology; D008564:Membrane Potentials; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure; D009243:NAD / Q000378:metabolism*; D010539:Permeability; D011065:Poly(ADP-ribose) Polymerases / Q000235:genetics / Q000502:physiology*; D021381:Protein Transport
D051033:Apoptosis Inducing Factor; D005420:Flavoproteins; D008565:Membrane Proteins; C494830:AIFM1 protein, mouse; D009243:NAD; D011065:Poly(ADP-ribose) Polymerases