Thrombin binding to GPIbalpha induces integrin alphaIIbbeta3 dependent platelet adhesion to fibrin in ex vivo flowing whole blood.
D000085:Acetates / Q000494:pharmacology; D000925:Anticoagulants / Q000494:pharmacology; D001769:Blood; D045744:Cell Line, Tumor; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000494:pharmacology; D006801:Humans; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010477:Perfusion; D010973:Platelet Adhesiveness; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000502:physiology; D019038:Platelet Glycoprotein GPIb-IX Complex; D011485:Protein Binding; D013917:Thrombin / Q000378:metabolism* / Q000502:physiology; D013927:Thrombosis / Q000209:etiology / Q000473:pathology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000085:Acetates; D000925:Anticoagulants; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009842:Oligopeptides; D010446:Peptide Fragments; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D019038:Platelet Glycoprotein GPIb-IX Complex; C094990:adhesion receptor; C027539:fibrinopeptides gamma; D014443:Tyrosine; C047981:arginyl-glycyl-aspartic acid; D005337:Fibrin; D005340:Fibrinogen; C084062:lamifiban; D013917:Thrombin