Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models.
We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 microCi were well tolerated by healthy A/JCr mice for (213)Bi-18B7 and (188)Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 microCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.
Dadachova
E
E
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. edadachova@aecom.yu.edu
Bryan
R A
RA
Frenkel
A
A
Zhang
T
T
Apostolidis
C
C
Nosanchuk
J S
JS
Nosanchuk
J D
JD
Casadevall
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001729:Bismuth; D001772:Blood Cell Count; D003453:Cryptococcosis / Q000097:blood / Q000532:radiotherapy*; D005260:Female; D005355:Fibrosis; D006402:Hematologic Diseases / Q000097:blood* / Q000209:etiology*; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology*; D051379:Mice; D008805:Mice, Inbred A; D010976:Platelet Count; D016499:Radioimmunotherapy / Q000009:adverse effects*; D011868:Radioisotopes / Q000627:therapeutic use; D012211:Rhenium
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D012211:Rhenium; D001729:Bismuth