Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD.
Significantly increased plasma total homocysteine levels (t-Hcys) appeared in treated Huntington disease (HD) patients compared to controls and untreated HD subjects. Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.
Andrich
Jürgen
J
Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
Saft
Carsten
C
Arz
Anneliese
A
Schneider
Birgit
B
Agelink
Markus W
MW
Kraus
Peter H
PH
Kuhn
Wilfried
W
Müller
Thomas
T
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002491:Central Nervous System Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D018450:Disease Progression; D004347:Drug Interactions; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000175:diagnosis; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009460:Neurologic Examination; D009687:Nuclear Proteins / Q000235:genetics
D015415:Biomarkers; D002491:Central Nervous System Agents; C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D006710:Homocysteine