A genome-wide search for type 2 diabetes susceptibility genes in West Africans: the Africa America Diabetes Mellitus (AADM) Study.
The incidence of type 2 diabetes is growing rapidly, not only in developed countries but also worldwide. We chose to study type 2 diabetes in West Africa, where diabetes is less common than in the U.S., reasoning that in an environment where calories are less abundant, incident cases of type 2 diabetes might carry a proportionately greater genetic component. Through the Africa America Diabetes Mellitus (AADM) study, we carried out a genome-wide linkage analysis of type 2 diabetes in a cohort of 343 affected sibling pairs (691 individuals) enrolled from five West African centers in two countries (Ghana: Accra and Kumasi; Nigeria: Enugu, Ibadan, and Lagos). A total of 390 polymorphic markers were genotyped, and multipoint linkage analysis was conducted using the GENEHUNTER-PLUS and ASM programs. Suggestive evidence of linkage was observed in four regions on three chromosomes (12, 19, and 20). The two largest logarithm of odds scores of 2.63 and 1.92 for chromosomes 20q13.3 and 12q24, respectively, are particularly interesting because these regions have been reported to harbor diabetes susceptibility genes in several other populations and ethnic groups. Given the history of forced migration of West African populations during the slave trade, these results should have considerable relevance to the study of type 2 diabetes in African Americans.
Rotimi
Charles N
CN
Department of Microbiology, National Human Genome Center at Howard University, College of Medicine, Washington, DC, USA. crotimi@howard.edu
Chen
Guanjie
G
Adeyemo
Adebowale A
AA
Furbert-Harris
Paulette
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Parish-Gause
Debra
D
Zhou
Jie
J
Berg
Kate
K
Adegoke
Olufemi
O
Amoah
Albert
A
Owusu
Samuel
S
Acheampong
Joseph
J
Agyenim-Boateng
Kofi
K
Eghan
Benjamin A
BA
Oli
Johnnie
J
Okafor
Godfrey
G
Ofoegbu
Ester
E
Osotimehin
Babatunde
B
Abbiyesuku
Fayeofori
F
Johnson
Thomas
T
Rufus
Theresa
T
Fasanmade
Olufemi
O
Kittles
Rick
R
Daniel
Harold
H
Chen
Yuanxiu
Y
Dunston
Georgia
G
Collins
Francis S
FS
Guass
Debra
D
D000354:Africa, Western; D002874:Chromosome Mapping; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008875:Middle Aged
D005819:Genetic Markers