A family-based association study of attention-deficit hyperactivity disorder and dopamine D2 receptor TaqI A alleles.
BACKGROUND
Over the past 5 years, considerable progress has been made in the identification of polymorphic variation within monoamine system genes that are associated with the attention-deficit hyperactivity disorder (ADHD) phenotype. In this study, we investigated the association of the dopamine D2 receptor (DAD2) TaqI A and ADHD in a Taiwanese sample.


METHODS
The sample consisted of 98 children with ADHD and 154 of their parents. ADHD cases were ascertained from the Child Psychiatric Clinics at Chang Gung Memorial Hospital in the Taipei area, Taiwan. A diagnosis of ADHD was made following clinical interviews plus completion of a standard maternal interview and Conner's revised rating scales by a parent and teacher. Association of DRD2 TaqI A polymorphism in this sample was investigated using a haplotype-based haplotype relative-risk method.


RESULTS
Among our subjects, there was no significant difference in transmission rates between DRD2 TaqI A1 and A2 alleles.


CONCLUSIONS
The results of this study do not support DRD2 playing a major role in Taiwanese children with ADHD.
Huang
Yu-Shu
YS
Department of Child Psychiatry, Chang Gung Memorial Hospital, Taoyuan.
Lin
Shih-Ku
SK
Wu
Yu-Yu
YY
Chao
Chia-Chen
CC
Chen
Chih-Ken
CK
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002648:Child; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D019914:Taq Polymerase
D017448:Receptors, Dopamine D2; D019914:Taq Polymerase