Effect of bovine lactoferrin on a transmissible AIDS-like disease in mice.
The effect of bovine lactoferrin (bLF) was examined on an AIDS-like disease (ALD) in mice. Induction of disease was achieved by inoculation with infected cell-free plasma from diseased mice to uninfected ones. The effect of treatment with bLF was investigated when administered simultaneously with the virus, 20 days prior to infection, or 20 days after infection. Animals underwent clinical surveillance and enumeration of white blood cells (WBC) and lymphocytes, as well as fluorescent staining of CD4 and CD8 bearing cells. Simultaneous administration of bLF and virus did not affect the pattern of ALD progress along the course of the experiment. Pretreatment with bLF prior to virus inoculation abolished on day 21 the detrimental effect of viral infection that lasted for two months. An opposite outcome was observed when bLF was administered 20 days after the virus. It seems that bLF had played a preventive role for a restricted period of time. However, an adverse response was elicited when bLF was administered 20 days after viral infection.
Department of Immunology, Kimron Veterinary Institute, Beit Dagan 50250, Israel. evgenial@moag.gov.il
E
E
Lubashevsky
O
O
Krifucks
R
R
Paz
J
J
Brenner
S
S
Savransky
Z
Z
Trainin
H
H
Ungar-Waron
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes; D005260:Female; D005434:Flow Cytometry; D006529:Hepatomegaly; D016130:Immunophenotyping; D007781:Lactoferrin / Q000276:immunology / Q000494:pharmacology*; D007958:Leukocyte Count; D018655:Lymphocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C; D016183:Murine Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D018709:Statistics, Nonparametric
D007781:Lactoferrin