Protective effects of electroacupuncture and Salviae Miltiorrhizae on myocardial ischemia/reperfusion in rabbits.
The aim of present study was to observe the protective effects of electroacupuncture (EA) and Salviae Miltiorrhizae (SM) on myocardial ischemia/reperfusion in rabbits. Acute ischemia/reperfusion of myocardium was set up by ligating left anterior descending branch of coronary artery in 24 rabbits which were divided randomly into control, EA, SM, and EA+SM group. Changes of plasma myocardial zymogram were found after ischemia in these groups. EA and SM were observed to decrease plasma IL-8 and epinephrine concentration and to increase 99mTc-MIBI intake ratio of myocardial mitochondrial, but enhancing or antagonistic effect between EA and SM was negligible. There was positive correlation between concentrations of plasma epinephrine and IL-8. The results indicated that EA and SM could reduce myocardial ischemia/reperfusion injury and protect myocardial mitochondrial by reducing concentrations of plasma epinephrine and IL-8. EA and SM could reduce the release of endogenic epinephrine, which was one of the mechanisms of lowering plasma IL-8.
Wang
Xiang-Rui
XR
Department of Anesiology of RenJi Hospital, Shanghai Second Medical University, Shanghai 200127, PR China. xiangruiwang@vip.sina.com
Lin
Han
H
Wang
Zhen-Hong
ZH
D000818:Animals; D003131:Combined Modality Therapy / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D015671:Electroacupuncture / Q000379:methods*; D004837:Epinephrine / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D017202:Myocardial Ischemia / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy*; D008517:Phytotherapy / Q000379:methods*; D011817:Rabbits; D011877:Radionuclide Imaging; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D016209:Interleukin-8; D004837:Epinephrine