A toll-like receptor that prevents infection by uropathogenic bacteria.
Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system.
Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.
Dekai
D
Zhang
Guolong
G
Zhang
Matthew S
MS
Hayden
Matthew B
MB
Greenblatt
Crystal
C
Bussey
Richard A
RA
Flavell
Sankar
S
Ghosh
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D003001:Cloning, Molecular; D018388:Codon, Terminator; D015169:Colony Count, Microbial; D004198:Disease Susceptibility; D004847:Epithelial Cells / Q000378:metabolism; D004926:Escherichia coli / Q000254:growth & development / Q000276:immunology / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000276:immunology* / Q000382:microbiology; D020869:Gene Expression Profiling; D006801:Humans; D007113:Immunity, Innate; D007668:Kidney / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors; D014162:Transfection; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D001743:Urinary Bladder / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology
D018388:Codon, Terminator; D008024:Ligands; D016328:NF-kappa B; D011956:Receptors, Cell Surface; D011993:Recombinant Fusion Proteins; C482902:TLR11 protein, human; C482903:Tlr11 protein, mouse; D051193:Toll-Like Receptors; D014409:Tumor Necrosis Factor-alpha