Chemokine mediated control of dendritic cell migration and function.
Dendritic cells (DC) have historically been viewed as a group of functionally homogeneous cell types that act to stimulate Ag-specific immune responses after migrating to secondary lymphoid organs. DC patterns of chemokine responsiveness have generally been viewed as similar among DC subtypes. Here we discuss recent studies that challenge this view by demonstrating that DC subtypes differ in their response to specific chemokines, their migration patterns, and their capacity to stimulate or inhibit immune response. Thus, individual chemokines may act to regulate the character, strength, and duration of Ag-specific immune responses in a manner that has not previously been appreciated.
Department of Medicine, Division of Cardiology, and Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA. michael.gunn@duke.edu
Michael Dee
MD
Gunn
D000818:Animals; D002465:Cell Movement; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D018121:Receptors, Cytokine / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D018925:Chemokines; D008024:Ligands; D018121:Receptors, Cytokine