Potential of chemotherapy-herb interactions in adult cancer patients.
OBJECTIVE
The purpose of this study was to examine the specific herbs or vitamins (HV) used by patients receiving chemotherapy. Specifically, the following aspects were investigated: (1) HV use among adult cancer patients receiving chemotherapy, (2) the frequency of potential chemotherapy-HV interactions, (3) communication patterns between oncologists and their cancer patients taking HV, and (4) patients' reactions to two hypothetical scenarios of chemotherapy-HV interactions.


METHODS
Adult cancer patients receiving chemotherapy at a university-based outpatient clinic over a 1-month period were sent a validated eight-page questionnaire regarding the use of complementary/alternative medicine, focusing on HV use. A total of 76 patients participated; relevant medical information was obtained from study participants' charts. The chemotherapy received was compared with HV use to assess for potentially detrimental chemotherapy-HV interactions.


RESULTS
HV use in patients receiving chemotherapy was common (78%), with 27% of the study participants being at risk of a detrimental chemotherapy-HV interaction. Most patients (>85%) would discontinue their HV or ask their medical oncologist for advice if a detrimental chemotherapy-HV interaction was suspected. Although most patients discussed HV use with their oncologist, the majority also relied on their friends and naturopathic physician for information regarding HV.


CONCLUSIONS
Considerable potential exists for detrimental chemotherapy-HV interactions. Methods to improve communication of HV use between cancer patients receiving chemotherapy and health-care practitioners are necessary to identify and minimize the risk of these interactions.
McCune
Jeannine S
JS
University of Washington, Seattle, WA 98195, USA. jmccune@u.washington.edu
Hatfield
Amy J
AJ
Blackburn
Anne A R
AA
Leith
Patricia O
PO
Livingston
Robert B
RB
Ellis
Georgiana K
GK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001294:Attitude to Health; D005260:Female; D041743:Herb-Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000523:psychology; D010349:Patient Compliance; D010353:Patient Education as Topic / Q000379:methods; D008517:Phytotherapy / Q000009:adverse effects*; D010865:Pilot Projects; D010946:Plants, Medicinal / Q000009:adverse effects*; D011369:Professional-Patient Relations; D011795:Surveys and Questionnaires; D013997:Time Factors; D014861:Washington
D000970:Antineoplastic Agents