Salt preference of congenic strains derived from the spontaneously hypertensive rat.
Previous studies using reciprocal crosses between the spontaneously hypertensive rat (SHR) and the normotensive Wistar-Kyoto (WKY) strain suggested a role for the Y chromosome in the SHR's exaggerated preference for saline solutions. We have reexamined the role of the Y chromosome in the salt preference of the SHR using a consomic strain derived from SHR and Brown Norway (BN-Lx) progenitors. We also studied congenic lines in which regions of BN-Lx chromosomes 8 and 20 had been introgressed into the SHR genome. Animals were given a choice of water and 0.9% saline to drink over a period of 7 days and their total fluid intake (TFI; water plus saline) and saline preference (proportion of the TFI taken as saline) calculated. SHR bearing the BN-Lx Y chromosome had a significantly reduced saline preference when compared to progenitor SHR. Evidence was also found for the existence of a region on chromosome 8, which influences fluid intake in the SHR. The causative genes involved in these effects however remain to be determined.
Di Nicolantonio
Robert
R
Department of Physiology, University of Melbourne, Victoria, Melbourne 3010, Australia. robertdn@unimelb.edu.au
Kren
Vladimir
V
Zidek
Vaclav
V
Pravenec
Michal
M
D000818:Animals; D020296:Animals, Congenic; D001066:Appetite / Q000235:genetics* / Q000502:physiology; D003433:Crosses, Genetic; D004327:Drinking Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR / Q000235:genetics* / Q000378:metabolism; D011921:Rats, Inbred WKY; D017673:Sodium Chloride, Dietary / Q000378:metabolism*; D013045:Species Specificity; D014998:Y Chromosome
D017673:Sodium Chloride, Dietary