Use of intravenous polymyxin B during continuous venovenous hemodialysis.
Described here is the case of a 23-year-old male with Acinetobacter baumannii sepsis and acute renal failure requiring continuous venovenous hemodialysis treated successfully with intravenous polymyxin B. The drug was administered as a loading dose of 2.5 mg/kg, followed by 2 doses of 1 mg/kg on days 4 and 8, then 0.8 mg/kg daily to complete a 24-day course. A discussion of dosing recommendations for polymyxins in dialysis is presented.
Department of Internal Medicine, Division of Infectious Diseases, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430 USA. juan.sarria@ttuhsc.edu
J C
JC
Sarria
F
F
Angulo-Pernett
R C
RC
Kimbrough
C S
CS
McVay
A M
AM
Vidal
D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000302:isolation & purification; D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000328:Adult; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009104:Multiple Trauma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D011112:Polymyxin B / Q000008:administration & dosage*; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D018570:Risk Assessment; D016896:Treatment Outcome
D011112:Polymyxin B