The potential use of stem cells for cochlear repair.
In light of the currently defined characteristics of stem cells, a re-evaluation of hair cell regeneration in birds suggests that there may be a stem cell population located in the inner ear. It is yet to be determined if the mammalian cochlea contains stem cells, but the presence of a mammalian vestibular stem cell population would not appear to be out of the realm of possibility. This paper reviews the latest advances in stem cell biology and suggests that stem cells may be an appropriate biological tool to be used for cochlear repair. The potential use of several types of stem cells, including embryonic, neural and hematopoietic stem cells, as agents for cochlear repair is examined.
Parker
Mark A
MA
Department of Otology and Laryngology, Harvard Medical School, Boston, Mass., USA. mark.parker@tch.harvard.edu
Cotanche
Douglas A
DA
D000818:Animals; D001755:Blastocyst / Q000166:cytology; D002454:Cell Differentiation; D003051:Cochlea / Q000166:cytology / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000502:physiology; D034381:Hearing Loss / Q000628:therapy*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*