A GABA(B) mystery: the search for pharmacologically distinct GABA(B) receptors.
The classification of neurotransmitter receptors into distinct pharmacological subtypes is of major importance in drug discovery. This quest is particularly important for neurotransmitter systems that are widely distributed. Because gamma-aminobutyric acid (GABA) receptors, both GABA(A) and GABA(B), are found throughout the neuroaxis, they are likely involved in all central nervous system functions. Accordingly, the therapeutic promise of GABA(B) receptor manipulation depends upon the identification of subtypes than can be specifically targeted.
Enna
S J
SJ
Department of Pharmacology, Toxicology and Therapeutics, Kansas University School of Medicine, 3901 Rainbow Blvd., Kansas City, Kansas 66160, USA. senna@kumc.edu
D000085:Acetates / Q000494:pharmacology; D000588:Amines; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001418:Baclofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D001596:Benzylamines / Q000494:pharmacology; D003509:Cyclohexanecarboxylic Acids; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D000077206:Gabapentin; D006801:Humans; D015394:Molecular Structure; D009025:Morpholines / Q000494:pharmacology; D010721:Phosphinic Acids / Q000494:pharmacology; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D012333:RNA, Messenger; D018080:Receptors, GABA-B / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid
C095804:(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid; D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D001596:Benzylamines; D003509:Cyclohexanecarboxylic Acids; D018755:GABA Agonists; D018756:GABA Antagonists; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D009025:Morpholines; D010721:Phosphinic Acids; D020033:Protein Isoforms; D012333:RNA, Messenger; D018080:Receptors, GABA-B; C052329:phaclofen; C083008:CGP 52432; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D001418:Baclofen