Personal recollections on the early development of taxol.
All of us who have worked with taxol in the laboratory and the clinic, and the many patients all over the world who have benefited from the drug, owe a great debt of gratitude to Monroe Wall, Mansukh Wani, and their colleagues for the initial isolation and characterization of this compound.
Horwitz
Susan Band
SB
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000266:history* / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000266:history* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D049673:History, 20th Century; D006801:Humans; D008870:Microtubules / Q000737:chemistry; D017239:Paclitaxel / Q000737:chemistry / Q000266:history* / Q000494:pharmacology; D020946:Taxus / Q000737:chemistry; D014481:United States
D000972:Antineoplastic Agents, Phytogenic; D001685:Biological Factors; D017239:Paclitaxel