Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis.
Two regimens of albendazole emulsion (AbzE), a novel formulation, were used in the treatment of 264 cases of hepatic cystic echinococcosis. AbzE 10 mg/kg per day (calculated by albendazole base) was administered orally to 71 cases for 6 months to over 1 year. Imaging evaluation at the end of courses showed overall efficacy in 97.2%, (cure rate 60.6%, and inefficacy rate 2.8%); The follow-up study on 62 cases 3-4 years post therapeutic courses showed overall efficacy in 92.0% (cure rate 83.9%, ineffective rate 1.5% and recurrence rate 6.5%); Abz 12.5 mg/kg per day was administered orally to 193 cases for 3 months to over 1 year, resulting in an overall efficacy of 97.9%, (cure rate 75.1% and inefficacy rate 2.1%). The follow-up study in 139 cases 2-4 years post treatment demonstrated efficacy in 89.2%, (cure rate 84.2% and recurrence rate 10.8%); Mild reversible adverse reactions were observed in 14.4% of the patients. Retreatment of recurrent hydatidosis patients with AbzE provided promising results. AbzE is considered to be superior to the albendazole tablet or capsule formulations currently used in treatment of liver cystic hydatid disease.
Chai
Junjie
J
Xinjiang Centers of Diseases Prevention and Control National Hydatid Disease Center of China, Xinjiang, Urumqi 830002, PR China. jchai@xj.cninfo.net
Menghebat
Wei
Jiao
J
Deyu
Sun
S
Bin
Liang
L
Jincao
Shi
S
Chen
Fu
F
Xiong
Li
L
Yiding
Mao
M
Xiuling
Wang
W
Dolikun
Guliber
Yanchun
Wang
W
Fanghua
Gao
G
Shuhua
Xiao
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015766:Albendazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004444:Echinococcosis, Hepatic / Q000188:drug therapy* / Q000469:parasitology; D004446:Echinococcus; D004655:Emulsions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000871:Anthelmintics; D004655:Emulsions; D015766:Albendazole