Bioactive constituents from Asparagus cochinchinensis.
Bioassay-directed fractionation of the dried roots of Asparagus cochinchinensis led to the isolation of a new spirostanol saponin, asparacoside (1), two new C-27 spirosteroids, asparacosins A (2) and B (3), a new acetylenic derivative, 3' '-methoxyasparenydiol (4), and a new polyphenol, 3'-hydroxy-4'-methoxy-4'-dehydroxynyasol (6), as well as five known phenolic compounds, asparenydiol (5), nyasol (7), 3' '-methoxynyasol (8), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (9), and trans-coniferyl alcohol (10). Compounds 1, 6, and 8 demonstrated moderate cytotoxicities in a panel comprised of KB, Col-2, LNCaP, Lu-1, and HUVEC cells, with IC(50) values ranging from 4 to 12 microg/mL. The structures were determined by spectroscopic and chemical methods.
Zhang
Hong-Jie
HJ
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy (M/C877), College of Pharmacy, the University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
Sydara
Kongmany
K
Tan
Ghee Teng
GT
Ma
Cuiying
C
Southavong
Bounhoong
B
Soejarto
D Doel
DD
Pezzuto
John M
JM
Fong
Harry H S
HH
D000107:Acetylation; D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D027761:Asparagus Plant / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D007812:Laos; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D019380:Anti-HIV Agents; D012503:Saponins; D013150:Spirostans; C483638:asparacoside; C483641:asparacosin A; C483643:asparacosin B