Loss of heterozygosity on chromosome 13q: suggestion of a candidate tumor suppressor gene in sporadic breast cancer.
In order to corroborate the assumption that a candidate tumor suppressor gene is located on chromosome 13q21-22 between D13S1313 and D13S162, we examined loss of heterozygosity of six microsatellite markers in this region in 98 sporadic breast tumors. Our data demonstrate that loss of heterozygosity at 13q21-22 is not solely caused by genetic changes in BRCA2, but is also attributable to another gene in this region. There is strong indication of a new tumor suppressor gene located between D13S1313 and D13S162, most probably adjacent to D13S1308, which could play a role in sporadic breast cancer.
Department of Obstetrics and Gynecology, University of Vienna, Vienna, Austria. dan.castillo-tong@akh-wien.ac.at
Dan
D
Tong
Eva
E
Schuster
Klaus
K
Czerwenka
Sepp
S
Leodolter
Robert
R
Zeillinger
D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002882:Chromosomes, Human, Pair 13; D017931:DNA Primers; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D024682:BRCA2 Protein; D017931:DNA Primers; D004273:DNA, Neoplasm