Parallel synthesis of terminal alkynes using a ROMPgel-supported ethyl 1-diazo-2-oxopropylphosphonate.
ROMPgel-supported ethyl 1-diazo-2-oxopropylphosphonate has been prepared, and the supported reagent has been effectively employed in the conversion of a variety of aldehydes into terminal alkynes under mild reaction conditions. The influence of cross-link structure, comonomers, and polymer structure on reaction efficiency has been examined. [structure: see text]
Department of Chemistry, Imperial College London, Exhibition Road, London SW7 2AZ, England. agmb@imperial.ac.uk
Anthony G M
AG
Barrett
Brian T
BT
Hopkins
Andrew C
AC
Love
Livio
L
Tedeschi