Parkinson's disease patients with bilateral subthalamic deep brain stimulation gain weight.
Weight, body mass index (BMI) and energy expenditure/energy intake (EE/EI) was studied in 19 Parkinson's disease (PD) patients after subthalamic deep brain stimulation (STN-DBS) versus 14 nonoperated ones. Operated patients had a significant weight gain (WG, + 9.7 +/- 7 kg) and BMI increase (+ 4.7 kg/m2). The fat mass was higher after STN-DBS. Resting EE (REE; offdrug/ON stimulation) was significantly decreased in STN-DBS patients, while their daily energy expenditure (DEI) was not significantly different. A significant correlation was found among WG, BMI increase, and pre-operative levodopa-equivalent daily dose, their reduction after STN-DBS, and the differential REE related to stimulation and the REE in the offdrug/OFF stimulation condition. In conclusion, STN-DBS in PD induces a significant WG associated with a reduction in REE without DEI adjustment.
Service de Neurologie, Hôpital Haut Lévèque, Pessac, France.
Frédéric
F
Macia
Caroline
C
Perlemoine
Irène
I
Coman
Dominique
D
Guehl
Pierre
P
Burbaud
Emmanuel
E
Cuny
Henri
H
Gin
Vincent
V
Rigalleau
François
F
Tison
D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D003131:Combined Modality Therapy; D004292:Dominance, Cerebral / Q000502:physiology*; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology / Q000628:therapy; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D016896:Treatment Outcome; D015430:Weight Gain / Q000502:physiology*
D000978:Antiparkinson Agents; D007980:Levodopa