[Markers in patients with squamous cell carcinoma of the oral cavity. Expression and long-term follow-up of VEGF, FLT-1 and Tie2 in serum].
OBJECTIVE
The quantification of serum or plasma levels of angiogenic factors in patients with malignancies aims at the description of these factors or their receptors and allows a tissue independent study of biological tumor behavior.


METHODS
In 51 patients with untreated squamous cell carcinoma of the oral cavity (SCCOC) and 10 healthy controls, plasma levels of VEGF and serum levels of the VEGF-receptor FLT-1 and the Ang1-receptor Tie2 were measured. Using an ELISA technique, the concentration of these factors was measured preoperatively and postoperatively over a period of 5 weeks.


RESULTS
No statistically significant correlation could be found between the serum and plasma levels and the clinical or pathological parameters. There was no difference between the patients with SCCOC and healthy controls.


CONCLUSIONS
In patients with SCCOC, plasma levels of VEGF and serum levels of FLT-1 and Tie-2 do not provide any further information on the biological tumor behavior like proliferation or expression of metastases.
Klinik für Kiefer- und Gesichtschirurgie, Universitätsspital Zürich. praxis@kiefer-gesichtschirurgie.net
R
R
Schimming
N-C
NC
Gellrich
G
G
Eyrich
D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016326:Extracellular Matrix Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D042787:Receptor, TIE-2 / Q000097:blood*; D012016:Reference Values; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1
D014408:Biomarkers, Tumor; D016326:Extracellular Matrix Proteins; D042461:Vascular Endothelial Growth Factor A; C501162:FLT1 protein, human; D042787:Receptor, TIE-2; D040281:Vascular Endothelial Growth Factor Receptor-1