Preimplantation genetic diagnosis for Y-linked diseases: why not?
The introduction of intracytoplasmic sperm injection (ICSI) has allowed men with severe oligozoospermia and non-obstructive azoospermia to achieve fertilization and parenthood. A significant number of these men have translocation defects affecting the long arm of the Y chromosome. Chromosomal anomalies are considered to be a major contributor to the genetic risks of fertilization treatment by ICSI. The most frequently documented genetic cause of male infertility is Y-chromosome deletions, which have been shown to be transmitted to 100% of male offspring. It is appropriate to open a debate on the use of preimplantation genetic diagnosis with ICSI for severe male factor associated with Y-chromosome aberrations.
The Egyptian IVF-ET Centre, 3 Road 161, Hadayek El-Maadi, Cairo, 11431, Egypt. ivf@link.net
Ragaa
R
Mansour
D000818:Animals; D041322:Chromosomes, Human, Y; D030342:Genetic Diseases, Inborn / Q000175:diagnosis*; D006801:Humans; D019836:Preimplantation Diagnosis / Q000941:ethics; D020554:Sperm Injections, Intracytoplasmic