Effect of ibuprofen on bilirubin-albumin binding.
Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.
Division of Neonatology, California Pacific Medical Center, San Francisco, California, USA. ligand@centurytel.net
Charles E
CE
Ahlfors
D000418:Albumins / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D001663:Bilirubin / Q000097:blood*; D001665:Binding Sites; D006801:Humans; D007052:Ibuprofen / Q000097:blood / Q000493:pharmacokinetics*; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood*; D013444:Sulfisoxazole / Q000493:pharmacokinetics
D000418:Albumins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013444:Sulfisoxazole; D001663:Bilirubin; D007052:Ibuprofen