Prevention of thromboembolism with low-molecular-weight heparin in orthopedic surgery: a 5-year experience.
A regimen of prophylaxis of thromboembolism with low molecular weight heparin (LMWH) and unfractionated heparin (UFH) in orthopedic surgery is presented. Over a 5-year period, 11,905 patients have been operated in all fields of orthopedic surgery in a big trauma center. In 498 cases, deep vein thrombosis (DVT) was clinically suspected and phlebography was performed: 122 patients had confirmed DVT (rate 0.98%); 59.8% of the DVT were limited to the calf. Nineteen pulmonary embolisms (rate 0.16%) were diagnosed (3 lethal). Heparin-induced thrombocytopenia type II was diagnosed in 12 of 122 patients. Only one of these had received LMWH. The related rates of DVT were highest for tibial head fractures (12.4%), total knee replacement (6.7%), and multiple trauma (6.4%). The extent of DVT was most severe in multiple trauma. The results proved the regimen to be of good clinical use and showed that more attention has to be paid to fractures, especially of the knee; and to patients with multiple injuries.
Department of Orthopedic Surgery, BG Trauma Centre, Hamburg, Germany. michael.wenzl@chirurgie.uni-luebeck.de
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002986:Clinical Trials as Topic; D004341:Drug Evaluation; D005260:Female; D006493:Heparin / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects*; D019990:Perioperative Care; D010690:Phlebography; D011183:Postoperative Complications / Q000517:prevention & control; D012189:Retrospective Studies; D013923:Thromboembolism / Q000175:diagnosis / Q000517:prevention & control*; D013927:Thrombosis / Q000139:chemically induced
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin