[Effects of hypertriglyceridemia on platelet activities in endogenous hypertriglyceridemic patients].
OBJECTIVE
To explore the effects of hypertriglyceridemia on platelet activities.


METHODS
The plasma prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fg), blood platelet count (BPC) and platelet alpha granule membrane protein-140 (GMP-140) levels in endogenous hypertriglyceridemic patients were determined, and the relationship between platelet activities and fasting plasma lipids was assessed.


RESULTS
It was found that PT, Fg levels, BPC and plasma GMP-140 concentration showed no statistically significant difference between the control and hypertriglyceridemic subjects (P > 0.05). PT was correlated with the levels of plasma BG and apo E (r = 0.500, P = 0.012), the levels of Fg was positively correlated with BG (r = 0.598, P = 0.000), and BPC of HTG subjects was negatively correlated with TG (r = -0.489, P < 0.05). GMP-140 content was positively correlated with the levels of plasma TC and LDL-C (r = 0.647, 0.833, P < 0.01); in HTG patients it was inversely correlated with age and PT (r = -0.480, -0.490, P < 0.05).


CONCLUSIONS
All of these indicated that increasing of coagulation activity in hypertriglyceridemic patients was correlated with dysfunction of plasma lipids and change of apolipoproteins levels. Plasma GMP-140 was not obviously correlated with plasma TG content, but was positively correlated with plasma TC and LDL-C contents.
Apolipoprotein Research Unit, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Tao
T
Shen
Bing-wen
BW
Liu
Yu
Y
Liu
Huai
H
Bai
Zu-hui
ZH
Zhang
D000368:Aged; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism*; D010314:Partial Thromboplastin Time; D015539:Platelet Activation; D011517:Prothrombin Time; D014280:Triglycerides / Q000097:blood
D008077:Lipoproteins, LDL; D019007:P-Selectin; D014280:Triglycerides; D005340:Fibrinogen