The effects of tiazofurin on basal and amphetamine-induced motor activity in rats.
The effects of tiazofurin (TR; 2-beta-d-ribofuranosylthiazole-4-carboxamide), a purine nucleoside analogue on basal and amphetamine (AMPH)-induced locomotor and stereotypic activity of adult Wistar rat males were studied. The animals were injected with low (3.75, 7.5, and 15 mg/kg ip) and high (62.5, 125, and 250 mg/kg ip) TR doses. Neither low nor high TR doses influenced basal locomotor and stereotypic activity in comparison with the corresponding controls treated with saline only. However, pretreatment with TR at any dose applied, except for the lowest one, significantly decreased AMPH-induced (1.5 mg/kg ip) locomotor activity, while AMPH-induced stereotypic activity was inhibited with the two highest TR doses. In addition, TR was detected in the brain by HPLC already 15 min after the injection (125 mg/kg ip) to reach a maximum 2 h after the administration and was detectable in this tissue during the next 4 h. Our results indicate that TR modifies central regulation of the motor activity, possibly by influencing dopaminergic (DA-ergic) transmission.
Laboratory of Electrophysiology and Behaviour, Department of Neurobiology and Immunology, Institute for Biological Research, 29th November 142, 11060 Belgrade, Serbia and Montenegro. janac@ibiss.bg.ac.yu
Branka
B
Janać
Vesna
V
Pesić
Rosica
R
Veskov
Slavica
S
Ristić
Jelena
J
Tasić
Vesna
V
Piperski
Sabera
S
Ruzdijić
Milan
M
Jokanović
Petar
P
Stukalov
Ljubisa
L
Rakić
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D012254:Ribavirin; D000661:Amphetamine; C033706:tiazofurin