Skin strain and its influence on systemic exposure to a glycol ether in offset printing workers.
Under workplace conditions, it is difficult to prove the influence of skin lesions on skin penetration by chemical substances. The aim of the present study was to show whether systemic exposure to glycol ether increases due to lesions of the skin in printing workers. 28 male printers, exposed to 2-(2-butoxyethoxy)ethanol (BEE), were interviewed about the workplace exposure by a standardized questionnaire. The systemic exposure in printers was determined by biological monitoring of the main metabolite of BEE butoxyethoxyacetic acid (BEAA) in urine. Furthermore, clinical examination of the skin, transepidermal water loss, capacitance and skin surface pH measurements were carried out. Erythema and scaliness were the most important factors showing an effect on dermal absorption. The mean urinary BEAA excretions for printers with skin lesions on the hands were higher (20.62 mg/l for scaliness and 14.40 mg/l for erythema) compared to that for printers without detectable skin lesions (12.08 mg/l for scaliness and 13.03 mg/l for erythema). Bioengineering measurements to predict skin strain and percutaneous absorption were only supportive. We were able to show that by using a multiple spectrum of methods an enhancement of percutaneous absorption of BEE could be demonstrated in workers with skin lesions.
Institute and Out-Patient Clinic for Occupational, Social and Environmental Medicine, University Erlangen-Nuremberg, Erlangen, Germany. gintautas.korinth@rzmail.uni-erlangen.de
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G
Korinth
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T
Göen
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M
Lakemeyer
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HC
Broding
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H
Drexler
D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000503:physiopathology; D004306:Dose-Response Relationship, Immunologic; D004784:Environmental Monitoring; D000431:Ethanol; D004986:Ether / Q000009:adverse effects*; D005026:Ethylene Glycols / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D010328:Patch Tests; D011327:Printing; D011336:Probability; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012869:Skin Absorption / Q000187:drug effects; D012879:Skin Physiological Phenomena
D005026:Ethylene Glycols; D004986:Ether; D000431:Ethanol