[Potential role of hormesis in risk assessment in occupational toxicology].
Over the past few decades there has been a gradual decline in concentrations of airborne chemical agents in the workplace. This improvement in the workplace has led to a concomitant need to study the effects of low dose exposure in order to assess possible risks. The paradigm used in toxicology to evaluate risk and to establish exposure limits for substances employed in industry, is that the dose-response relationship is expressed by a linear model for carcinogenic substances and by a threshold model for those which are not. Alongside these two traditional models, there has been a recent proposal to describe relationships using hormesis which is characterised by a biphasic curve corresponding to moderate stimulation resulting from response to low doses, and by inhibition at high doses. Although hormesis has been widely observed in experimental contexts, it still has to be tested in occupational toxicology to determine the possibility of obtaining a more accurate evaluation of the risk of exposure to low doses present in the workplace.
Iavicoli
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Istituto di Medicina del Lavoro, Università Cattolica del Sacro Cuore, Roma.
Carelli
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G
D006801:Humans; D009787:Occupational Medicine / Q000379:methods*; D018570:Risk Assessment / Q000379:methods; D014116:Toxicology / Q000379:methods*