Human papillomavirus, cytomegalovirus, and adeno-associated virus infections in pregnant and nonpregnant women with cervical intraepithelial neoplasia.
Two hundred eight cervical specimens from two groups of subjects, 165 nonpregnant women and 53 pregnant women with cervical intraepithelial neoplasia (CIN) of grades I to III, were positive by PCR analyses for human papillomaviruses (HPVs), adeno-associated virus type 2 (AAV 2), and human cytomegalovirus (HCMV) in 67, 6, and 4.1% of the cases, respectively. The presence of AAV 2 infection was more frequently associated with pregnancy (17 versus 2.4%) and HPV-positive cervices (odds ratio = 6.358) than HCMV was. Increased HPV infection was strongly associated (P < 0.001) with a higher CIN grade, but there is no evidence that AAV 2 and HCMV infections have any impact on CIN development.
Division of Molecular Medicine, Rudjer Boskovic Institute, University of Zagreb, 10000 Zagreb, Croatia. grce@irb.hr
M
M
Grce
K
K
Husnjak
M
M
Matovina
N
N
Milutin
L
L
Magdic
O
O
Husnjak
K
K
Pavelic
D000328:Adult; D003587:Cytomegalovirus / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology; D000229:Dependovirus / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D010322:Parvoviridae Infections / Q000150:complications* / Q000453:epidemiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011252:Pregnancy Complications, Neoplastic / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000821:virology*