In vitro activity of daptomycin against gram-positive European clinical isolates with defined resistance determinants.
The in vitro activity of daptomycin against 337 gram-positive European clinical isolates with known resistance genes was determined. The MIC ranges for Staphylococcus aureus, enterococci, pneunococci, and streptococci were 0.03 to 1, 0.25 to 8, 0.12 to 1, and 0.06 to 8 micro g/ml, respectively. For only one streptococcus isolate and seven enterococcus isolates was the MIC 8 micro g/ml.
Fluit
Ad C
AC
Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. A.C.Fluit@lab.azu.nl
Schmitz
Franz-Josef
FJ
Verhoef
Jan
J
Milatovic
Dana
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D017576:Daptomycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005060:Europe; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000235:genetics*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000900:Anti-Bacterial Agents; D017931:DNA Primers; D004269:DNA, Bacterial; D017576:Daptomycin