Paroxetine decreases respiratory irregularity of linear and nonlinear measures of respiration in patients with panic disorder. A preliminary report.
Previous studies indicate that serotonin reuptake inhibitors do not appear to have serious cardiac side effects. However, the effects of these agents on respiratory measures have not been studied in detail. Several studies indicate that patients with anxiety exhibit irregular breathing patterns as measured by tidal volume and respiratory rate. In this study, we evaluated the effects of a serotonin reuptake inhibitor, paroxetine, on respiratory variability in patients with panic disorder (n = 13), using linear and nonlinear measures of regularity, approximate entropy (APEN) and a measure of chaos, the largest Lyapunov exponent (LLE), with pre- and posttreatment lung volume time series (256 s long sampled at 4 Hz). Our results show that paroxetine significantly decreases some of the linear measures of variability and supine APEN and standing LLE of lung volume series after successful treatment. The implications of these findings on respiratory and cardiovascular function have been discussed.
Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich., USA. vikramyershr@yahoo.com
Vikram Kumar
VK
Yeragani
Radhakrishna
R
Rao
Manuel
M
Tancer
Thomas
T
Uhde
D000328:Adult; D000704:Analysis of Variance; D019277:Entropy; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D017711:Nonlinear Dynamics; D016584:Panic Disorder / Q000188:drug therapy* / Q000503:physiopathology; D017374:Paroxetine / Q000627:therapeutic use*; D011187:Posture / Q000502:physiology; D012016:Reference Values; D012119:Respiration / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors