[Clinical and laboratory investigation of four acute myeloid leukemia patients with t(3;3) translocation].
OBJECTIVE
To investigate the clinical and laboratory characteristics of four acute myeloid leukemia with t(3;3) translocation.


METHODS
Bone marrow cell chromosome karyotype analysis were carried out with direct method and short-term culture and R-banding technique.


RESULTS
Four AML patients with t(3;3) translocation were identified. They did not obtain complete remission after chemotherapy and the median survival time was 4.5 months.


CONCLUSIONS
t(3;3) translocation is a rare chromosome abnormality, which has mostly been found in myeloid leukemia and the prognosis of these patients is poor.
The First Affiliated Hospital of Medical College of Zhejiang University, Institute of Hematology, Hangzhou 310003, China.
Zhi-mei
ZM
Chen
Jian-guo
JG
Wu
Jie
J
Jin
Ji-yu
JY
Lou
Mao-fang
MF
Lin
D000328:Adult; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic