Human tibia bone marrow blood perfusion by non-invasive near infrared spectroscopy: a new tool for studies on microgravity.
Human tibia bone marrow (BM) and tibialis anterior muscle (TA) perfusion index (PI) was assessed non-invasively by near infrared spectroscopy. A decrease in the postis-chaemic reperfusion capability of the human tibia BM and TA muscle was observed for increasing age i.e., PI increases linearly as a function of age, starting from 30 years, both for BM (0.062 %/year, from -4.185 to -0.967 %/s) and TA muscle (0.046 %/year, from -5.760 to -3.883 %/s). The results define a "normal" baseline and demonstrate the sensitivity of the method to PI changes. The present technique should allow one to investigate physio-pathological effects induced by microgravity on tibia BM blood perfusion.
Department of Radiology, Geneva University Hospital, Switzerland. binzoni@medecine.unige.ch
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Binzoni
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Blanchi
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Fasel
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Bounameaux
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Hiltbrand
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Delpy