[Chronic myelogenous leukemia following therapy for pineal germinoma].
A 13-year-old male was diagnosed as having pineal germinoma in July 1998. Since then, he had been treated with tumor excision, radiation and chemotherapy. In June 2002, he was diagnosed as having the chronic phase of chronic myelogenous leukemia (CML), and following treatment with interferon-alpha, he achieved hematological complete remission. Although CML is rare in secondary leukemia, the present case seemed therapy-related CML because of its clinical course, as the CML occurred after the period with radiation and chemotherapy. This is the first case of secondary CML following therapy for intracranial tumors.
Department of Internal Medicine, Hiroshima City Hospital.
Masaaki
M
Noda
Tomoko
T
Shoda
Yasuo
Y
Takimoto
Hajime
H
Okita
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018237:Germinoma / Q000628:therapy*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology* / Q000628:therapy; D008297:Male; D016609:Neoplasms, Second Primary; D010871:Pinealoma / Q000628:therapy*; D012074:Remission Induction
D000970:Antineoplastic Agents; D016898:Interferon-alpha; D006918:Hydroxyurea