Cancer after pre-eclampsia: follow up of the Jerusalem perinatal study cohort.
OBJECTIVE
To compare the incidence of cancer among women with and without a history of pre-eclampsia.


METHODS
Cohort study.


METHODS
Jerusalem perinatal study of women who delivered in three large hospitals in West Jerusalem during 1964-76.


METHODS
37 033 women.


METHODS
Age adjusted and multivariable adjusted hazard ratios for cancer incidence for the entire cohort and for women who were primiparous at study entry.


RESULTS
Cancer developed in 91 women who had pre-eclampsia and 2204 who did not (hazard ratio 1.27, 95% confidence interval 1.03 to 1.57). The risk of site specific cancers was increased, particularly of the stomach, ovary epithelium, breast, and lung or larynx. The incidence of cancer of the stomach, breast, ovary, kidney, and lung or larynx was increased in primiparous women at study entry who had a history pre-eclampsia.


CONCLUSIONS
A history of pre-eclampsia is associated with increases in overall risk of cancer and incidence at several sites. This may be explained by environmental and genetic factors common to the development of pre-eclampsia and cancer in this population.
Paltiel
Ora
O
Braun School of Public Health and Community Medicine, Hadassah-Hebrew University, Jerusalem 91120, Israel. ora@vms.huji.ac.il
Friedlander
Yehiel
Y
Tiram
Efrat
E
Barchana
Micha
M
Xue
Xiaonan
X
Harlap
Susan
S
D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology*; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy