Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis.
OBJECTIVE
The aim of the study was to examine the validity and reliability of a quantifiable measure of inflammation using magnetic resonance imaging (MRI) in children with juvenile dermatomyositis (JDM).


METHODS
Children with active JDM, inactive JDM and healthy children received detailed assessments of recognized measures of muscle inflammation including muscle strength (manual muscle testing and myometry) and function (Childhood Myositis Assessment Scale, Childhood Health Assessment Questionnaire), the muscle enzymes lactate dehydrogenase (LDH) and creatine kinase (CK) and T2-weighted MRI scans of the thigh muscles, and these values were correlated with each other.


RESULTS
Ten children with active JDM, 10 with inactive JDM and 20 healthy children completed the study. There was no significant difference in ages between the three groups. The MRI T2 relaxation times were significantly increased in active JDM compared with inactive JDM and healthy children (P = 0.05), indicating a detectable increase in inflammation within the muscles. There were also good correlations between the MRI scores and the measures of muscle strength and function; however, there was no correlation between the MRI and muscle enzymes.


CONCLUSIONS
The MRI T2 relaxation time can be used as a quantitative measure of muscle inflammation and it has good correlations with other measures of disease activity.
Juvenile Dermatomyositis Research Centre, Institute of Child Health, London, UK S.Maillard@ich.ucl.ac.uk
S M
SM
Maillard
R
R
Jones
C
C
Owens
C
C
Pilkington
P
P
Woo
L R
LR
Wedderburn
K J
KJ
Murray
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D018482:Muscle, Skeletal / Q000503:physiopathology*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013848:Thigh