The possible prognostic significance of immunophenotype in feline alimentary lymphoma: a pilot study.
Twenty-three retrospective biopsy specimens from feline intra-abdominal lymphomas including tumours affecting the gastrointestinal tract, mesenteric lymph nodes, liver and spleen were immunohistochemically labelled with monoclonal antibodies to CD79a (B-cell phenotype) and CD3 (T-cell phenotype). Positive labelling occurred in 15 (65%) and 6 (26%) of the tumours, respectively. No statistically significant relationship was found between tumour cell immunophenotype and age, breed, or gender. There was no significant difference in survival time between the two immunophenotypes, based on the 16 cats for which this information was available.
Department of Pathology and Infectious Diseases, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK.
J C
JC
Patterson-Kane
B Perrins
BP
Kugler
K
K
Francis
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D017252:CD3 Complex / Q000096:biosynthesis; D051925:CD79 Antigens; D002371:Cat Diseases / Q000378:metabolism / Q000473:pathology*; D002415:Cats; D004064:Digestive System / Q000473:pathology*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology* / Q000662:veterinary*; D008297:Male; D008643:Mesentery / Q000473:pathology; D011379:Prognosis; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology
D015703:Antigens, CD; D017252:CD3 Complex; D051925:CD79 Antigens; D011947:Receptors, Antigen, B-Cell