Antineuropathic effects of the antibiotic derivative spicamycin KRN5500.
Excellence in neuropathic pain management continues to challenge the ability of health care providers. Current medications are helpful but often create significant side effects or simply fail to provide adequate analgesia. We report here on a serendipitous finding of the successful attenuation of neuropathic pain in a patient with long-standing monoclonal gammopathy, Raynaud's disease, and neuropathic pain who received the trial chemotherapeutic agent KRN5500. This finding led to animal studies that have provided support for the possible use of KRN5500 in the treatment of neuropathic pain in humans as well as some insight into the possible mechanism(s) of action of this drug.
Center for Functional Pain Neuroimaging and Therapy Research, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. dborsook@dtrx.com
David
D
Borsook
Annabel Davis
AD
Edwards
D000368:Aged; D000700:Analgesics / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000473:pathology; D011115:Polyneuropathies / Q000188:drug therapy* / Q000473:pathology; D011684:Purine Nucleosides / Q000008:administration & dosage*; D011928:Raynaud Disease / Q000188:drug therapy / Q000473:pathology
D000700:Analgesics; D000900:Anti-Bacterial Agents; D011684:Purine Nucleosides; C015502:septacidin