Pretransplantation risk factors for graft loss after liver transplantation in cirrhotic patients; effect of cytomegalovirus serologic status.
This study analyzes the effect of the preoperative variables of donors and recipients on graft survival after liver transplantation (LT). Preoperative data from a cohort of 122 cirrhotic patients who underwent primary LT were evaluated prospectively. The influence of these variables as risk factors for graft loss was assessed. During follow-up (median: 33 (19-59) months) there were 38 (31.1%) graft losses (22 deaths and 16 retransplantations). Variables that showed statistical association with graft loss on univariate analysis (P<0.150) were: positivity of the CMV serologic status of the donor (P=0.028), the UNOS score of recipient (P=0.048) and advanced donor age (P=0.124). When these variables were introduced into the multivariate study, the CMV serologic status of the donor was the only variable that was independently associated with graft loss (relative risk=2.97, 95% confidence interval=1.05-8.39; P=0.039). Donor CMV-seropositivity is a significant pretransplantation determinant for graft loss in liver transplant recipients.
Gastroenterology Department, Hospital de Mataro, Ctra. Cirera s/n, Mataro, 08304 Barcelona, Spain. jmcastellvi@csm.scs.es
Josep Maria
JM
Castellví
Xavier
X
Xiol
Jordi
J
Guardiola
Isabel
I
Sabaté
Manuel
M
Roca
Carme
C
Lama
Joan
J
Figueras
Eduardo
E
Jaurrieta
Luis
L
Casais
D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000601:surgery*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000145:classification*; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D017211:Treatment Failure