Periodontal disease and poor obstetrical outcome.
Maternal infective processes sustained especially by Gram-negative anaerobic bacteria like periodontal disease, during pregnancy, have been demonstrated to perturb the physiologic course of parturition through inflammatory cytokine production, sometimes resulting in preterm labor, preterm premature rupture of membranes and preterm low birth weight. In a matched case-control study, the hypothesis that poor oral health of pregnant women is a risk factor for low birth weight (LBW) was evaluated. Gingival crevicular fluid levels of PGE2 and IL-1beta were measured in order to determine whether mediator levels were related to current pregnancy outcome. Results indicate that GCF-PGE2 and GCF-IL-1beta levels are significantly higher in preterm low birth weight (PLBW) mothers as compared with normal birth weight controls. The data confirm that there is a possible correlation between periodontal problems typical of pregnancy and the occurrence of complications such as preterm low birth weight.
Department of Surgical Science, University of L'Aquila, Unit of Obstetrics and Gynecology, Avezzano Hospital, Italy.
G
G
Carta
G
G
Persia
K
K
Falciglia
P
P
Iovenitti
D016022:Case-Control Studies; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism; D005881:Gingiva / Q000378:metabolism; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D018836:Inflammation Mediators / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism; D010518:Periodontitis / Q000150:complications* / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000382:microbiology; D011256:Pregnancy Outcome
D018836:Inflammation Mediators; D007375:Interleukin-1; D015232:Dinoprostone