Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.
Vascular endothelial growth factor (VEGF) is a cytokine overexpressed in hypoxic and malignant pathologies. VEGF induces vascular hyperplasia, new bone formation, and edema. These histological abnormalities characterize hypertrophic osteoarthropathy. We describe a case of pulmonary hypertrophic osteoarthropathy with high circulating VEGF levels. Removal of the lung tumor led to a dramatic disappearance of the skeletal abnormalities and to reduction of circulating VEGF levels. Histochemical studies of the excised tumor confirmed abnormal VEGF production.
National Institute of Cardiology and National Institute of Respiratory Diseases, Mexico City, Mexico.
Francisco
F
Olán
Margarita
M
Portela
Carmen
C
Navarro
Miguel
M
Gaxiola
Luis H
LH
Silveira
Victor
V
Ruiz
Manuel
M
Martínez-Lavín
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000097:blood*
D042461:Vascular Endothelial Growth Factor A