Responses of rat left ventricle cardiomyocytes to constant 2G-hypergravity.
2G-hypergravity during 33-days led to hypertrophy of cardiomyocytes (CMC) in rat left ventricle accompanied by capillary number and diameter growth. CMC ultrastructure was normal at all experimental stages. Number of intermitochondrial junctions (IMJ) rose after 33 days of 2G in subsarcolemmal pericapillary zone of CMC, indicating probably to enlarged CMC energy needs. Changes in myocardium achieved during 33 days of 2G were reversible at 39 days of 1G (except IMJ number). Repeated 5-days 2G influence (after 33 days of primary 2G influence followed by 39 days of 1G) led again to CMC hypertrophy and to IMJ number rise in all zones of mitochondria localisation. Primary 5-days 2G influence didn't result in CMC hypertrophy, IMJ number rose only in subsarcolemmal pericapillary zone.
Lomonosov Moscow State University, Biological Faculty, Moscow, Russia. tlipina@hotbox.ru
T V
TV
Lipina
M V
MV
Shornikova
V N
VN
Frolov
I B
IB
Krasnov
Yu S
YS
Chentsov