Analysis of Fas (Apo-1/CD95) expression in non-small cell lung cancer.
Defects in the apoptotic pathway represent a critical element in the progression of neoplastic disease and may also concur to determine treatment efficacy at the cellular level. Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling. In this study we analyzed, by immunohistochemistry, the expression of Fas protein in a group of 68 NSCLC (non-small cell lung cancer) specimens. Statistical analyses did not show any significant relationship between Fas immunohistochemical expression and clinical parameters of lung cancer patients, except for nodal status. Our data do not support the use of Fas as a molecular prognostic role in NSCLC. On the other hand, considering the role of the Fas-pathway in chemotherapy-induced apoptosis, further studies are required to analyze the potential value of Fas expression in predicting the response of NSCLC patients to chemotherapy.
Third Division of Infective Diseases, D. Cotugno Hospital, Department of Cardiological, Respiratory and Thoracic Medical Sciences, Second University of Naples, Naples, Italy.
Vincenzo
V
Esposito
Alfonso
A
Baldi
Giuseppina
G
Liuzzi
Giuseppe
G
Tonini
Bruno
B
Vincenzi
Paolo
P
Persichetti
Mario
M
Santini
Vincenzo
V
Ambrogi
Tommaso Claudio
TC
Mineo
Vincenzo
V
Montesarchio
Ernst
E
Wolner
Feliciano
F
Baldi
Angela M
AM
Groeger
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D015703:Antigens, CD / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008175:Lung Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D019014:fas Receptor / Q000378:metabolism*
D015703:Antigens, CD; D019014:fas Receptor