Apoptosis as a tool for therapeutic agents in haematological diseases.
Apoptosis, an active mechanism of cell death, is an important process in many biological systems. Apoptosis is thought to contribute to many disease processes. This notion has raised expectations that therapeutic opportunities will naturally follow once a better understanding of these processes has been achieved. The regulation of apoptosis in normal and malignant haematological diseases represents an important therapeutic approach in the treatment of leukaemia and lymphoma. This review summarises recent developments in the clinical manipulation of apoptosis pathways in haematological therapy.
Alenzi
Faris Q B
FQ
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, PO Box 1982, Dammam 31451, Kingdom of Saudi Arabia. faris_alenzi@hotmail.com
Wyse
Richard K H
RK
Altamimi
Waleed G
WG
D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006402:Hematologic Diseases / Q000188:drug therapy* / Q000473:pathology; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics
D000906:Antibodies; D000970:Antineoplastic Agents