Pharmaceutical prospects for RNA interference.
RNA interference has proven to be a powerful tool in gene function validation. Recently, the first studies were published reporting a disease-modulating activity of the technique, suggesting a promise for RNA interference as a novel therapeutic strategy. This review discusses the recent advancements in realizing the clinical utility of RNA-interference.
Schiffelers
Raymond M
RM
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands. Raymond@intradigm.com
Woodle
Martin C
MC
Scaria
Puthupparampil
P
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006801:Humans; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000138:chemical synthesis / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*
D034741:RNA, Small Interfering