Salt preference of congenic strains derived from the spontaneously hypertensive rat.
Previous studies using reciprocal crosses between the spontaneously hypertensive rat (SHR) and the normotensive Wistar-Kyoto (WKY) strain suggested a role for the Y chromosome in the SHR's exaggerated preference for saline solutions. We have reexamined the role of the Y chromosome in the salt preference of the SHR using a consomic strain derived from SHR and Brown Norway (BN-Lx) progenitors. We also studied congenic lines in which regions of BN-Lx chromosomes 8 and 20 had been introgressed into the SHR genome. Animals were given a choice of water and 0.9% saline to drink over a period of 7 days and their total fluid intake (TFI; water plus saline) and saline preference (proportion of the TFI taken as saline) calculated. SHR bearing the BN-Lx Y chromosome had a significantly reduced saline preference when compared to progenitor SHR. Evidence was also found for the existence of a region on chromosome 8, which influences fluid intake in the SHR. The causative genes involved in these effects however remain to be determined.
Department of Physiology, University of Melbourne, Victoria, Melbourne 3010, Australia. robertdn@unimelb.edu.au
Robert
R
Di Nicolantonio
Vladimir
V
Kren
Vaclav
V
Zidek
Michal
M
Pravenec
D000818:Animals; D020296:Animals, Congenic; D001066:Appetite / Q000235:genetics* / Q000502:physiology; D003433:Crosses, Genetic; D004327:Drinking Behavior / Q000502:physiology; D005518:Food Preferences / Q000502:physiology; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR / Q000235:genetics* / Q000378:metabolism; D011921:Rats, Inbred WKY; D017673:Sodium Chloride, Dietary / Q000378:metabolism*; D013045:Species Specificity; D014998:Y Chromosome
D017673:Sodium Chloride, Dietary