Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult.
Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.
Kim
Darrick S H L
DS
Program for Collaborative Research in Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. dkim@curxcel@com
Kim
Jin Yung
JY
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D002396:Catechols / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D016229:Amyloid beta-Peptides; D002396:Catechols; D018696:Neuroprotective Agents; D010936:Plant Extracts; C040115:shogaol