Interferon targeted genes in host defense.
Type I Interferons (IFN) induce the expression of IFN-stimulated genes (ISG). The products of some of these genes have direct antiviral effects, others are involved in immunoregulation or modulate signaling pathways and gene expression, and others yet are mediators of cell growth and death. Their role in autoimmune diseases has been found to be both beneficial and detrimental.
The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, MD, USA.
Myriam S
MS
Kunzi
Paula M
PM
Pitha
D000818:Animals; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007369:Interferon Inducers; D007370:Interferon Type I / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D017471:Receptors, Interferon / Q000502:physiology*; D011994:Recombinant Proteins; D015398:Signal Transduction; D014777:Virus Diseases / Q000276:immunology
D007369:Interferon Inducers; D007370:Interferon Type I; D017471:Receptors, Interferon; D011994:Recombinant Proteins