Knockout mouse points to second form of tryptophan hydroxylase.
A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1(-/-)mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1(-/-) mice showed no observed behavioral differences from wild-type littermates. Veenstra-Vanderweele and Cook discuss the ramifications of these findings and what they might mean for designing drugs that target the expression and activity of TPH in differing tissues.
Veenstra-VanderWeele
Jeremy
J
Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA.
Cook
Edwin H
EH
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid; D012701:Serotonin / Q000096:biosynthesis; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000378:metabolism
D007527:Isoenzymes; D012701:Serotonin; D014365:Tryptophan Hydroxylase