Saponins from the bark of Nephelium maingayi.
Activity-guided fractionation of the bark of Nephelium maingayi, collected in Indonesia, led to the isolation of six new saponins (1-6). The aglycon of 4 was determined to be a new compound, 7alpha-methoxyerythrodiol, and those of 1-3 and of 5 and 6 were identified as erythrodiol and maniladiol (16beta-hydroxyamyrin), respectively. The structures of 1-6 were determined on the basis of spectral data interpretation, and the absolute configurations of their component monosaccharides were determined as their thiazolidine derivatives after acid hydrolysis. Of the isolates, only compounds 1 and 5 showed very weak cytotoxic activity against a panel of human tumor cell lines.
Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Aiko
A
Ito
Hee-Byung
HB
Chai
Leonardus B S
LB
Kardono
Francisca M
FM
Setowati
Johar J
JJ
Afriastini
Soedarsono
S
Riswan
Norman R
NR
Farnsworth
Geoffrey A
GA
Cordell
John M
JM
Pezzuto
Steven M
SM
Swanson
A Douglas
AD
Kinghorn
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D007214:Indonesia; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured; D001617:beta-Glucosidase / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D001617:beta-Glucosidase