Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus.
Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12beta,13alpha-dihydroxytriptonide (4), respectively, from 1 and 2. Product 4 is a new compound.
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Li-Li
LL
Ning
Jian
J
Han
Xing-Yi
XY
Zhang
Hong-Zhu
HZ
Guo
Kai-Shun
KS
Bi
De-An
DA
Guo
D001711:Biotransformation; D030008:Catharanthus / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D004224:Diterpenes / Q000493:pharmacokinetics*; D004852:Epoxy Compounds; D010616:Phenanthrenes / Q000493:pharmacokinetics*; D014315:Triterpenes / Q000493:pharmacokinetics*
D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; D014315:Triterpenes; C001899:triptolide; C084079:triptonide