Finite-element simulation of cooling of realistic 3-D human head and neck.
Rapid cooling of the brain in the first minutes following the onset of cerebral ischemia is a potentially attractive preservation method. This computer modeling study was undertaken to examine brain-cooling profiles in response to various external cooling methods and protocols, in order to guide the development of cooling devices suitable for deployment on emergency medical vehicles. The criterion of successful cooling is taken to be the attainment of a 33 degrees C average brain temperature within 30 min of treatment. The transient cooling of an anatomically correct realistic 3-D head and neck with realistically varying local tissue properties was numerically simulated using the finite-element method (FEM). The simulations performed in this study consider ice packs applied to head and neck as well as using a head-cooling helmet. However, it was found that neither of these cooling approaches satisfies the 33 degrees C temperature within 30 min. This central conclusion of insubstantial cooling is supported by the modest enhancements reported in experimental investigations of externally applied cooling. The key problem is overcoming the protective effect of warm blood perfusion, which reaches the brain via the uncooled carotid arterial supply and effectively blocks the external cooling wave from advancing to the core of the brain. The results show that substantial cooling could be achieved in conjunction with neck cooling if the blood speed in the carotid artery is reduced from normal by a factor of 10. The results suggest that additional cooling means should be explored, such as cooling of other pertinent parts of the human anatomy.
Dennis
Brian H
BH
Frontier Simulation Software for Industrial, Science Collaborative Research Center, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Muguro-ku, Tokyo 153-8505, Japan.
Eberhart
Robert C
RC
Dulikravich
George S
GS
Radons
Steve W
SW
D000465:Algorithms; D001831:Body Temperature / Q000502:physiology; D001833:Body Temperature Regulation / Q000502:physiology*; D002545:Brain Ischemia / Q000503:physiopathology / Q000628:therapy; D003080:Cold Temperature; D003198:Computer Simulation; D017679:Cryotherapy / Q000379:methods*; D004735:Energy Transfer; D005240:Feasibility Studies; D020342:Finite Element Analysis; D006257:Head / Q000098:blood supply / Q000502:physiology*; D006260:Head Protective Devices; D006801:Humans; D008954:Models, Biological; D008955:Models, Cardiovascular; D009333:Neck / Q000098:blood supply / Q000503:physiopathology*; D013814:Thermal Conductivity; D013817:Thermography / Q000379:methods