Hypocrellin derivative with improvements of red absorption and active oxygen species generation.
A novel diamino-substituted hypocrellin derived from hypocrellin B (HB) was synthesized by a mild method. The red absorption of the resulting product was significantly enhanced relative to the parent hypocrellins and any other hypocrellin derivatives, and the active oxygen species generating abilities were enhanced distinctly, which will remarkably improve its photodynamic therapy effectiveness.
Xu
Shangjie
S
Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China.
Chen
Shen
S
Zhang
Manhua
M
Shen
Tao
T
D017323:Dihematoporphyrin Ether / Q000032:analysis / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D010569:Perylene / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry*; D019800:Phenol; D017319:Photosensitizing Agents / Q000737:chemistry*; D011809:Quinones / Q000032:analysis / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry* / Q000378:metabolism*
D017319:Photosensitizing Agents; D011809:Quinones; D017382:Reactive Oxygen Species; D019800:Phenol; D010569:Perylene; D017323:Dihematoporphyrin Ether; C048388:hypocrellin A