Dual HIV-1 infection associated with rapid disease progression.
Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per microL was very rapid (<3.4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.
Gottlieb
Geoffrey S
GS
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195-8070, USA. gottlieb@u.washington.edu
Nickle
David C
DC
Jensen
Mark A
MA
Wong
Kim G
KG
Grobler
Jandre
J
Li
Fusheng
F
Liu
Shan-Lu
SL
Rademeyer
Cecilia
C
Learn
Gerald H
GH
Karim
Salim S Abdool
SS
Williamson
Carolyn
C
Corey
Lawrence
L
Margolick
Joseph B
JB
Mullins
James I
JI
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D000328:Adult; D021121:Branched DNA Signal Amplification Assay; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000175:diagnosis* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood / Q000276:immunology; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015163:Superinfection / Q000175:diagnosis / Q000276:immunology / Q000821:virology; D019562:Viral Load
D012367:RNA, Viral