Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst.
Central mucoepidermoid carcinoma (MEC) is an entity whose origin is still controversial. Glandular odontogenic cyst (GOC) is a recently described lesion whose relationship to low-grade central MEC has been reported in the literature. Our aim was to assess the cytokeratin (CK) profile of central MEC and GOC, and compare the results with CK expression in salivary gland MEC and odontogenic cysts and tumors. Eighty-five cases, including 6 central MECs, 23 salivary gland MECs, 10 GOCs, 34 odontogenic cysts and 12 ameloblastomas, were studied through immunohistochemistry using eleven monoclonal anti-CK antibodies. All central MECs expressed CKs 5, 7, 8, 14, and 18 and all GOCs expressed CKs 5, 7, 8, 13, 14, and 19. Comparing CK expression from GOC and central MEC we found differences in CKs 18 (30% vs 100%) and 19 (100% vs 50%). Central MEC and GOC are probably distinct entities with CK profiles similar to lesions of glandular and odontogenic origins, respectively, and expression of CKs 18 and 19 could be useful in their differential diagnosis.
Oral Pathology, School of Dentistry, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, 157 Vila Isabel, CEP: 21550-030, Rio de Janeiro/RJ, Brazil. ramoafop@yahoo.com
Fábio Ramôa
FR
Pires
Sow-Yeh
SY
Chen
Danyel Elias
DE
da Cruz Perez
Oslei Paes
OP
de Almeida
Luiz Paulo
LP
Kowalski
D000328:Adult; D000368:Aged; D018277:Carcinoma, Mucoepidermoid / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007571:Jaw Diseases / Q000378:metabolism* / Q000473:pathology; D007633:Keratins / Q000032:analysis*; D008297:Male; D008336:Mandibular Diseases / Q000378:metabolism / Q000473:pathology; D008439:Maxillary Diseases / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000737:chemistry* / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000737:chemistry* / Q000473:pathology
D007633:Keratins