Inhibitors of antibiotic efflux in resistant Enterobacter aerogenes and Klebsiella pneumoniae strains.
In Enterobacter aerogenes and Klebsiella pneumoniae, efflux provides efficient extrusion of antibiotics and contributes to the multidrug resistance phenotype. One of the alkoxyquinoline derivatives studied here, 2,8-dimethyl-4-(2'-pyrrolidinoethyl)-oxyquinoline, restores noticeable drug susceptibility to resistant clinical strains. Analyses of energy-dependent chloramphenicol efflux indicate that this compound inhibits the efflux pump mechanism and improves the activity of structurally unrelated antibiotics on multidrug-resistant E. aerogenes and K. pneumoniae isolates.
Chevalier
Jacqueline
J
EA2197, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
Bredin
Jérôme
J
Mahamoud
Abdallah
A
Malléa
Monique
M
Barbe
Jacques
J
Pagès
Jean-Marie
JM
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002701:Chloramphenicol / Q000378:metabolism / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D021902:Enterobacter aerogenes / Q000187:drug effects* / Q000378:metabolism*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000378:metabolism*; D010641:Phenotype; D011759:Pyrrolidines / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*
C483964:2,8-dimethyl-4-(2'-pyrrolidinoethyl)-oxyquinoline; D000900:Anti-Bacterial Agents; D011759:Pyrrolidines; D011804:Quinolines; D002701:Chloramphenicol