Identification of a Mycobacterium tuberculosis strain with stable, low-level resistance to isoniazid.
We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) --> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.
Division of Laboratory Systems, Public Health Practice Program Office, Centers for Disease Control Prevention, Atlanta, Georgia 30341, USA. bdm6@cdc.gov
Bereneice M
BM
Madison
Salman H
SH
Siddiqi
Leonid
L
Heifets
Wendy
W
Gross
Mike
M
Higgins
Nancy
N
Warren
Anthony
A
Thompson
Glenn
G
Morlock
John C
JC
Ridderhof
D000962:Antimalarials / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D016366:Open Reading Frames / Q000235:genetics; D014376:Tuberculosis / Q000382:microbiology
D000962:Antimalarials; D004269:DNA, Bacterial; D007538:Isoniazid