[Hepatic arterial infusion therapy for pancreatic cancer].
BACKGROUND
One of the most difficult factors in curing pancreatic carcinoma is hepatic metastases. Many patients who undergo curative resection have hepatic recurrence, and unresected patients with hepatic metastases have terribly poor prognosis.


OBJECTIVE
In this study, we evaluated the efficacy of hepatic arterial infusion therapy for pancreatic carcinoma.


METHODS
The subjects were 42 patients who underwent curative surgery, and 75 who were treated without resection over the past 10 years. A catheter was inserted from the femoral artery to the proper hepatic artery using the interventional technique. The main drug of this therapy was 5-fluorouracil.


RESULTS
The prophylactic therapy for curative resected cases was effective for pathologically mild venous permeation cases but not effective for severe venous permeation cases. Prophylactic hepatic arterial infusion therapy to prevent hepatic metastasis was not effective for unresected cases; however, for the patients with hepatic metastases this therapy was one of the factors for prolonging survival time.
Dept. of Surgery-II, Yokohama City University School of Medicine.
Yasuhiko
Y
Miura
Michio
M
Ueda
Osamu
O
Kunihiro
Toru
T
Kubota
Itaru
I
Endo
Hitoshi
H
Sekido
Shinji
S
Togo
Hiroshi
H
Shimada
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D011788:Quality of Life; D015996:Survival Rate
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil