Depletion rates of injected and ingested ivermectin from blood serum of penned white-tailed deer, Odocoileus virginianus (Zimmermann) (Artiodactyla: Cervidae).
Penned female and male white-tailed deer, Odocoileus virginianus (Zimmerman), were administered ivermectin both by direct subcutaneous injection and by ingestion of ivermectin-medicated whole kernel corn. Depletion rates of ivermectin were determined by biweekly and weekly assays of blood serum. No statistical differences were observed between mean peak ivermectin serum concentrations in deer (data of sexes combined) from injection and ingestion studies, and ivermectin concentrations decreased to below detectable within 21 d after injection and 14 d after ingestion.
USDA-ARS-Knipling-Bushland U.S. Livestock Insects Research Laboratory, 2700 Fredericksburg Road, Kerrville, TX 78028-9184, USA. jmpound@ktc.com
J Mathews
JM
Pound
J Allen
JA
Miller
Delbert D
DD
Oehler
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D001711:Biotransformation; D003670:Deer / Q000097:blood*; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate
D000871:Anthelmintics; D007559:Ivermectin