[Influence of interferon type I on dendritic cells in vitro - review].
Dendritic cells(DC) are specialized antigen-presenting cells that prime naive T cells to induce initial immune responses. The immature DC capture and process antigens in the periphery, then emigrate to lymphoid organs. There they complete their maturation by upregulating HLA-I, II molecules, costimulatory molecules (eg. CD80, CD86) and adhesive molecules (eg. CD50, CD54, CD58). More studies showed that in vitro only interferons type I (IFN-alpha, beta) accelerate DC maturation in a dose-dependent manner. The DC induced by IFN type I highly express HLA-A, B, C, HLA-DR, costimulatory molecules and adhesive molecules, and they express enhancing effect of T-cells stimulatory activity in vitro. Progress of research in this field was summarized in this paper.
Department of Hematology, Shanxi Clinical Hospital of Xi'an Jiaotong University, Xi'an 710068, China. sunbin@csrc.gov.cn
Xin-Hui
XH
Zhai
Wen-Li
WL
Zhao
D002478:Cells, Cultured; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D007370:Interferon Type I / Q000494:pharmacology*
D007370:Interferon Type I