[The levels of interleukin  8 in gingival crevicular fluids of chronic periodontitis].
OBJECTIVE
To study the changes of IL-8 levels in chronic periodontitis progress and correlation with clinical parameters.


METHODS
The concentrations and total amounts of IL-8 cytokine in gingival crevicular fluids by double antibody sandwich ABC ELISA in chronic periodontitis (before and after treatment) and healthy control group were determined. Clinical parameters were measured and analysed.


RESULTS
In the chronic periodontitis, IL-8 cytokine was detected,significantly higher than the healthy group. The total amounts of IL-8 and GCF had significant differences between the diseased and healthy groups, as well as between the groups before and after treatment (P<0.01, P<0.05, respectively), but no significant difference was found between these groups in the concentration of IL-8 (P>0.05). There was positive correlation between the total amounts of IL-8 and clinical parameters, between GCF volume and clinical parameters (P<0.01).


CONCLUSIONS
These data indicated that the total amounts of IL-8 exhibited dynamic changes upon progress of chronic periodontitis. The levels of IL-8 in GCF are valuable in judging the degree of chronic periodontitis and in guiding clinical treatment.
Department of Stomatology, Shanghai Sixth People's Hospital, Shanghai 200233, China.
D R
DR
Zou
Y W
YW
Liu
Y
Y
Chen
Q C
QC
Dai