Adherence to oral therapy for type 2 diabetes: opportunities for enhancing glycemic control.
OBJECTIVE
Although diet and exercise are important parts of type 2 diabetes treatment, most patients require pharmacological intervention with multiple agents to maintain adequate glycemic control. This article addresses the numerous patient-related, disease-related, and demographic variables affecting medication adherence in this patient population.


METHODS
Extensive review of scientific literature, clinical practice guidelines, and Internet sources.


CONCLUSIONS
Studies have demonstrated that treatments including multiple medications or frequent dosing had a negative impact on adherence. Practitioners have used several approaches in an effort to improve adherence to oral antidiabetic medical therapy, including increased communication between health care providers and patients, implementation of multidisciplinary programs, and use of treatment regimens with easier dosing (i.e., reduced number of drugs or doses taken per day).


CONCLUSIONS
Options for type 2 diabetes treatments that combine effective medications into a simpler oral-dosage form may motivate and improve patient adherence. Ultimately, simplifying dosing may lead to better glycemic control, thereby reducing the risks associated with long-term consequences of the disease.
University of Illinois, Chicago College of Pharmacy and College of Medicine at Rockford, Illinois, USA. davidb@uic.edu
David
D
Bartels
D000284:Administration, Oral; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D010349:Patient Compliance
D001786:Blood Glucose; D007004:Hypoglycemic Agents