Mysteries of the transferrin-transferrin receptor 1 interaction uncovered.
How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells? In this issue of Cell, Cheng et al., describe the molecular structure of the human TfR1-Tf complex, This atomic model shows that Tf binds laterally to the TfR1 dimer and extends into the gap between the bottom of the receptor ectodomain and the membrane.
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Children's Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031, Australia.
D000818:Animals; D006801:Humans; D007501:Iron / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011990:Receptors, Transferrin / Q000737:chemistry / Q000378:metabolism*; D014168:Transferrin / Q000737:chemistry / Q000378:metabolism*
D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron