The serotonin transporter gene in aggressive children with and without ADHD and nonaggressive matched controls.
Using an ethnically homogeneous sample of highly aggressive Caucasian children and their matched controls, we report differential associations of the 5HTTLPR and VNTR polymorphisms with ADHD and aggression, respectively. Given the small sample size and the preliminary nature of our findings, replication is necessary.
Department of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada.
Joseph H
JH
Beitchman
Kristen M
KM
Davidge
James L
JL
Kennedy
Leslie
L
Atkinson
Vivien
V
Lee
Solomon
S
Shapiro
Lori
L
Douglas
D000374:Aggression / Q000523:psychology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000523:psychology*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic / Q000235:genetics; D012701:Serotonin / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin