Accessory proteins in the biogenesis of G protein-coupled receptors.
Intracellular accessory proteins can be critical for G protein-coupled receptor (GPCR) biogenesis, including aspects of GPCR trafficking. Recent discoveries include the identification of multiple membrane-associated proteins that dictate not only the intracellular sequestration and/or transport of GPCRs, but also modulate-quite dramatically-GPCR ligand specificity subsequent to delivery to the cell surface. These exciting discoveries have shifted earlier paradigms of GPCR functionality.
Department of Pharmacology, University of California, Irvine 92697, USA.
J C
JC
Bermak
Q Y
QY
Zhou
D000818:Animals; D001693:Biological Transport, Active; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005326:Fetal Proteins; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008565:Membrane Proteins / Q000378:metabolism; D018832:Molecular Chaperones; D001678:Organelle Biogenesis; D011506:Proteins / Q000378:metabolism*; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
C476535:DNAJC14 protein, human; D005326:Fetal Proteins; D008024:Ligands; D008565:Membrane Proteins; D018832:Molecular Chaperones; D011506:Proteins; D017447:Receptors, Dopamine D1; D043562:Receptors, G-Protein-Coupled