Inhibition of beta-lactamase II of Bacillus cereus by penamaldic derivatives of penicillins.
The penamaldic derivatives of amoxicillin, ampicillin, and penicillins G and V, stabilized with Zn(2+), were obtained from a methanolic medium. The enzymatic kinetic results show that the these derivatives elicit reversible inhibition of the enzyme metallo-beta-lactamase from Bacillus cereus, with inhibition constant values determined at pH 7.0 and 25 degrees C.
Department of Physical Chemistry, School of Pharmacy, University of Granada, E-18071 Granada, Spain. mpgn@platon.ugr.es
Pilar Gutiérrez
PG
Navarro
Bartolomé Quintero
BQ
Osso
Raquel García
RG
Ortiz
Pedro J
PJ
Martínez De Las Parras
María I
MI
Martínez Puentedura
M Carmen
MC
Cabeza González
D000465:Algorithms; D001409:Bacillus cereus / Q000187:drug effects / Q000201:enzymology*; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007700:Kinetics; D010406:Penicillins / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D065093:beta-Lactamase Inhibitors
D004151:Dipeptides; D004791:Enzyme Inhibitors; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; C043897:penamaldic acid