Apolipoprotein E, amyloid, and Alzheimer disease.
Despite important inroads into the molecular pathology of Alzheimer disease, effective long-term treatment for the condition remains elusive. Among the many gene products that are recognized as factors in the disease is apolipoprotein ( (apoE). The risk that specific isoforms of apoE pose with regard to Alzheimer Disease clearly varies, and so the roles that apoE plays in the brain will be crucial to a full understanding of the disease and to efforts to develop effective therapies.
Bales
K R
KR
Neuroscience Discovery Research, Lilly Research Laboratories Indianapolis, IN 46285, USA.
Dodart
J C
JC
DeMattos
R B
RB
Holtzman
D M
DM
Paul
S M
SM
D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D000682:Amyloid / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice
D000682:Amyloid; D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E