[Rosuvastatin: pharmacologic features].
The development of more active and safe new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) will increase the armamentarium of therapeutic tools available to the physicians for antiatherosclerotic therapies. Rosuvastatin presents a promising pharmacological profile: high affinity for the enzyme, a relative high hydrophilicity, selective hepatic uptake and activity, minimal cytochrome P450-mediated metabolism. Clinically the drug displays the highest lipid-lowering efficacy in the class with a safety profile similar to the other statins. Drug interaction potential is reduced. Rosuvastatin effectively decreases triglycerides, triglyceride-rich lipoproteins, non-HDL cholesterol, and increases HDL cholesterol. All together these properties will favor the achievement of therapeutic goals in the treated patients.
Bernini
Franco
F
Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Università degli Studi, Campus Universiario, 43100 Parma. fbernini@unipr.it
Catapano
Alberico L
AL
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000517:prevention & control; D001711:Biotransformation; D002784:Cholesterol / Q000097:blood; D004347:Drug Interactions; D005464:Fluorobenzenes / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000517:prevention & control; D006949:Hyperlipidemias / Q000097:blood / Q000517:prevention & control; D000960:Hypolipidemic Agents / Q000494:pharmacology; D007249:Inflammation / Q000517:prevention & control; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood
D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D011743:Pyrimidines; D013449:Sulfonamides; D014280:Triglycerides; D000068718:Rosuvastatin Calcium; D002784:Cholesterol