Serious adverse incidents with the usage of low molecular weight heparins in patients with chronic kidney disease.
BACKGROUND
The aim of the study is to describe serious adverse events in patients with renal insufficiency administered low molecular weight heparins (LMWHs).


METHODS
Systematic case note review from July 2002 to March 2003, Hope Hospital, Salford, UK, was used.


RESULTS
Ten patients experienced an adverse incident on LMWH therapy. Five patients were on maintenance hemodialysis therapy, and 1 patient was on continuous ambulatory peritoneal dialysis therapy. Three patients had calculated creatinine clearances of 5, 11, and 33 mL/min (0.08, 0.18, and 0.55 mL/s), and 1 patient had an estimated glomerular filtration rate of 12 mL/min. Age range was 45 to 89 years. Indications for anticoagulation were suspected pulmonary embolism (1 patient), acute coronary syndrome (7 patients), severe nephrotic syndrome (1 patient), and postoperative venous thromboembolic prophylaxis (1 patient). Three patients also were administered aspirin; 1 patient, clopidogrel; and 3 patients, aspirin and clopidogrel. LMWHs used were enoxaparin (6 patients), tinzaparin (3 patients), and dalteparin sodium (1 patient). Bleeding sources were retroperitoneal (1 patient), spontaneous soft tissue (3 patients), gastrointestinal (2 patients), dialysis catheter and cannula sites (2 patients), hemorrhagic pericardial effusion (1 patient), and intracranial (1 patient). Activated partial thromboplastin time was prolonged in 7 of 10 patients, with no other identifiable cause found. Three patients died despite aggressive resuscitation, including packed red blood cell infusions and protamine sulfate administration. Eight of the 10 prescriptions for LMWHs were either started or continued within our directorate, giving an approximate incidence of major hemorrhagic events in patients with chronic kidney disease of 7.8%.


CONCLUSIONS
LMWHs administered at fixed-weight doses and without monitoring show unpredictable anticoagulant effects in patients with chronic kidney disease stages 4 and 5, leading to serious and even fatal adverse incidents.
Department of Renal Medicine, Hope Hospital, Salford, UK.
Vasim
V
Farooq
Janet
J
Hegarty
Thangavelu
T
Chandrasekar
Elizabeth H
EH
Lamerton
Sandip
S
Mitra
John B
JB
Houghton
Philip A
PA
Kalra
Stephen
S
Waldek
Donal J
DJ
O'Donoghue
Grahame N
GN
Wood
D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000453:epidemiology; D015897:Comorbidity; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology / Q000209:etiology; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight