Synthesis and SAR of 2-arylbenzoxazoles, benzothiazoles and benzimidazoles as inhibitors of lysophosphatidic acid acyltransferase-beta.
2-Arylbenzoxazoles, benzothiazoles and benzimidazoles were identified as new classes of potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-beta (LPAAT-beta). Effects of selected inhibitors on proliferation of tumor cells in vitro were investigated.
Gong
Baoqing
B
Cell Therapeutics, Inc., 201 Elliott Ave. W., Suite 400, Seattle, WA 98119, USA.
Hong
Feng
F
Kohm
Cory
C
Bonham
Lynn
L
Klein
Peter
P
D000217:Acyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D052160:Benzothiazoles; D001583:Benzoxazoles / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology
D001562:Benzimidazoles; D052160:Benzothiazoles; D001583:Benzoxazoles; D004791:Enzyme Inhibitors; D013844:Thiazoles; D000217:Acyltransferases; C018764:2-acylglycerophosphate acyltransferase; C005465:benzothiazole