[Detection of thrombus precursor protein and its clinical significance].
OBJECTIVE
To discuss the significance of the concentration change of plasma thrombus precursor protein (TpP) in the diagnosis of disseminated intravascular coagulation (DIC) or pre-DIC.


METHODS
Enzyme linked immunosorbent assay (ELISA) was used in the detection of plasma TpP in patients with different diseases (77) and normal adults (47). At the same time, other correlated markers were detected and statistical comparison was proceeded.


RESULTS
The concentration of TpP in the disease group (11.20 +/- 5.10) mg/L or the DIC (13.20 +/- 7.96) mg/L and non-DIC group (8.33 +/- 6.30) was obviously higher than that in the control group (1.29 +/- 1.02, P > 0.001). The concentration TpP in the DIC group was also obviously higher than that in the non-DIC group (P > 0.01). The rate of abnormal level of TpP in the DIC group was 100%, being higher than that of other markers related with DIC.


CONCLUSIONS
Results of this study and pertinent literature showed that TpP detection has higher specificity and sensitivity than D-Dimer or fibrinogen (Fbg) assay in the diagnosis of DIC or pre-DIC. It provides more referable values for the diagnosis, treatment and prognosis of DIC.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. ruiyang2001@hotmail.com
Wen-ning
WN
Wei
Rui
R
Yang
Yan
Y
Yang
Shan-jun
SJ
Song
D000328:Adult; D000368:Aged; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000175:diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005337:Fibrin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis
C465961:thrombus precursor protein, human; D005337:Fibrin