DNA variants in the human RAB3A gene are not associated with autism.
Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. Since Rab3a constitutive knockout mice react to novel stimuli with hyperactivity, a further search for association of RAB3A DNA variants with other neurobehavioral disorders such as attention deficit/hyperactivity disorder appears justified.
Institute of Anatomy, University of Zurich, Switzerland. p.dadamo@anatom.unizh.ch.
P
P
D'Adamo
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E
Bacchelli
F
F
Blasi
H-P
HP
Lipp
D
D
Toniolo
E
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Maestrini
D000818:Animals; D001321:Autistic Disorder / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology; D016022:Case-Control Studies; D002888:Chromosomes, Human, Pair 19; D005106:Exploratory Behavior / Q000502:physiology; D006801:Humans; D051379:Mice; D011110:Polymorphism, Genetic; D020826:rab3A GTP-Binding Protein / Q000235:genetics*
D020826:rab3A GTP-Binding Protein