ICOS: a new costimulatory ligand/receptor pair and its role in T-cell activion.
The inducible costimulator (ICOS) is a new member of the CD28/CD152 receptor family that regulates T-cell activation and function. ICOS binds to a specific ligand on antigen-presenting cells (APC) and cells of the peripheral tissue different from the CD28/CD152 ligands CD80 and CD86. ICOS-L can be induced by inflammatory stimuli in peripheral tissue and on some APC, including monocytes, but is downregulated in B-cell and myeloid leukemia. ICOS-L delivers distinct signals to T cells, presumably important for the maintenance of certain types of immune response, providing the rationale for the development of new therapeutic strategies for the treatment of diseases.
Richter
G
G
Labor für Transplantationsbiologie, Kinderklinik und Poliklinik des Klinikums rechts der Isar der Technischen Universität München, Germany. guenther.richter@lrz.tum.de
Burdach
S
S
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics; D006801:Humans; D060889:Inducible T-Cell Co-Stimulator Protein; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D015448:Leukemia, B-Cell / Q000235:genetics / Q000276:immunology; D007951:Leukemia, Myeloid / Q000235:genetics / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; C556692:ICOS protein, human; C556694:Icos protein, mouse; D060889:Inducible T-Cell Co-Stimulator Protein