Building mouse phenotype ontologies.
The structured description of mutant phenotypes presents a major conceptual and practical problem. A general model for generating mouse phenotype ontologies that involves combing a variety of different ontologies to better link and describe phenotypes is presented. This model is based on the Phenotype and Trait Ontology schema proposal and incorporates practical limitations and designing solutions in an attempt to model a testbed for the first phenotype ontology constructed in this manner, namely the mouse behavior phenotype ontology. We propose the application of such a model could provide curators with a powerful mechanism of annotation, mining and knowledge representation as well as achieving some level of free text disassociation.
MRC UK Mouse Genome Centre and Mammalian Genetics Unit, Harwell, Oxfordshire, England. g.gkoutos@har.mrc.ac.uk
G V
GV
Gkoutos
E C J
EC
Green
A M
AM
Mallon
J M
JM
Hancock
D
D
Davidson
D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D023281:Genomics / Q000706:statistics & numerical data; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D010641:Phenotype; D012984:Software