New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors.
A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.
Delbecq
Frédéric
F
Groupe de Recherches sur l'Inhibition de la Prolifération Cellulaire UPRES EA 2692, Equipe de Chimie Organique, Université des Sciences et Technologies de Lille, F-59655 Villeneuve d'Ascq, France.
Cordonnier
Guy
G
Pommery
Nicole
N
Barbry
Didier
D
Hénichart
Jean-Pierre
JP
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*; D000096926:Benzenesulfonamides
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D011480:Protease Inhibitors; D013449:Sulfonamides; D000096926:Benzenesulfonamides