Pancoast's syndrome in a patient with B-cell lymphoma diagnosed and confirmed with immunoglobulin gene rearrangement.
Pancoast's syndrome due to malignant lymphoma is extremely rare. A case of diffuse large B-cell lymphoma presenting as Pancoast's syndrome is described. A 66-year-old man complained of pain and weakness of the right arm, and CXR revealed a right apical lung tumour. Histological findings were consistent with it being a diffuse large cell type lymphoma and Southern blot analysis revealed clonal rearrangement of the immunoglobulin heavy-chain JH. Thus, the tumour in this patient was diagnosed to be diffuse large B-cell lymphoma. Malignant lymphoma is an extremely rare cause of Pancoast's syndrome and only five cases have been described. This is the first reported case of Pancoast's syndrome caused by B-cell lymphoma, which was accurately diagnosed by analysis of gene rearrangement.
Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan. f-t@tkh.att.ne.jp
Fumiyuki
F
Takahashi
Akihiko
A
Ohwada
Yoshie
Y
Higashihara
Yasuko
Y
Yoshioka
Toshimasa
T
Uekusa
Kazuhisa
K
Takahashi
Takashi
T
Dambara
Yoshinosuke
Y
Fukuchi
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002772:Cholera Toxin; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D010178:Pancoast Syndrome / Q000209:etiology*
D000970:Antineoplastic Agents; D002772:Cholera Toxin