Developmental changes of cytochrome c oxidase and citrate synthase in rat heart homogenate.
Activity of cytochrome c oxidase and citrate synthase in rat heart homogenates was determined in 5-, 15-, 28- and 60-day-old rats. The activity of both enzymes increased during postnatal development but their changes followed different kinetics. The membrane-bound cytochrome c oxidase reached its adult values during the early postnatal period, i.e. between days 5 and 15, whereas soluble matrix-localized citrate synthase also continued to increase between days 15 and 60. Our data indicate a relative excess of cytochrome c oxidase in neonatal cardiocytes.
Drahota
Z
Z
Center for Integrated Genomics, Academy of Sciences of the Czech Republic, Prague 4, Czech Republic.
Milerová
M
M
Stieglerová
A
A
Houstek
J
J
Ostádal
B
B
D000367:Age Factors; D000818:Animals; D002950:Citrate (si)-Synthase / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D004789:Enzyme Activation; D006321:Heart / Q000254:growth & development*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
D003576:Electron Transport Complex IV; D002950:Citrate (si)-Synthase