New potential calcium channel modulators: design and synthesis of compounds containing two pyridine, pyrimidine, pyridone, quinoline and acridine units under microwave irradiation.
The synthesis of bifunctional pyridine, pyrimidine, pyridone, quinoline and acridine derivatives was investigated using dialdehyde as a precursor. A rapid and efficient method was developed for the synthesis of a range of bifunctional monocyclic, bicyclic and tricyclic products related to 1,4-DHPs with the aim of finding new classes of biologically active compounds.
Tu
Shujiang
S
Department of Chemistry, Xuzhou Normal University, Key Laboratory of Biotechnology on Medical Plant, Jiangsu, Xuzhou, Jiangsu 221009, People's Republic of China. laotu2001@263.net
Miao
Chunbao
C
Fang
Fang
F
Youjian
Feng
F
Li
Tuanjie
T
Zhuang
Qiya
Q
Zhang
Xiaojing
X
Zhu
Songlei
S
Shi
Daqing
D
D000166:Acridines / Q000138:chemical synthesis; D015220:Calcium Channels / Q000378:metabolism*; D015195:Drug Design; D008872:Microwaves; D011725:Pyridines / Q000138:chemical synthesis; D011728:Pyridones / Q000138:chemical synthesis; D011743:Pyrimidines / Q000138:chemical synthesis; D011804:Quinolines / Q000138:chemical synthesis
D000166:Acridines; D015220:Calcium Channels; D011725:Pyridines; D011728:Pyridones; D011743:Pyrimidines; D011804:Quinolines