Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice.
Little is known about the genetics of social approach-avoidance behaviors. We measured social approach-avoidance of prepubescent female C57BL/6J, DBA/2J, FVB/NJ, AKR/J, A/J, and BALB/cJ mice towards prepubescent DBA/2J female mice. C57BL/6J mice showed the greatest predominance of approach, while BALB/cJ mice showed the greatest predominance of avoidance. Thus, this phenotype is affected by spontaneous genetic variation in mice and can be measured in an assay useful for future neurogenetic studies.
Brodkin
Edward S
ES
Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Room 111, Philadelphia, PA 19104-6140, USA. ebrodkin@mail.med.upenn.edu
Hagemann
Andrea
A
Nemetski
Sondra Maureen
SM
Silver
Lee M
LM
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010641:Phenotype; D012919:Social Behavior; D013045:Species Specificity