Assessment of environmental tobacco smoke exposure: urinary cotinine concentrations in children are strongly associated with the house dust concentrations of nicotine at home.
In the present study the possibility of using nicotine in house dust as an index of environmental tobacco smoke (ETS) exposure was evaluated in an environmental investigation of 23 children with asthma. A standardized procedure for house dust sampling of nicotine with a filter holder connected to a vacuum cleaner, for a defined time and area was developed (F-nicotine). Also, house dust sampling was carried out from the vacuum cleaner bags of the homes (VC-nicotine). There was a larger variation in VC-nicotine (13-655, median 66 microg/g) compared with F-nicotine (15-393 median 156 microg/g). There were statistically significant associations between an inquiry data based ETS exposure index on the one hand, and urinary cotinine concentrations in children (U-cotinine), F-nicotine and VC-nicotine of their homes, on the other. The strong correlation between U-cotinine and F-nicotine (rs = 0.93; P < 0.0001) indicates that the new standardized house dust sampling method should be useful in ETS exposure assessment. However, further validation by a larger sample size with repeated measurements in the same homes is needed.
Unit of Preventive Medicine, Heart and Lung Center and Dept of Occupational and Environmental Medicine, Lund University Hospital, SE-221 85 Lund, Sweden. stefan.willers@ymed.lu.se
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D000293:Adolescent; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003367:Cotinine / Q000652:urine*; D004391:Dust; D004781:Environmental Exposure; D005260:Female; D005731:Ganglionic Stimulants / Q000032:analysis*; D006798:Housing; D006801:Humans; D007223:Infant; D008297:Male; D009538:Nicotine / Q000032:analysis*; D014028:Tobacco Smoke Pollution / Q000032:analysis*; D014618:Vacuum
D015415:Biomarkers; D004391:Dust; D005731:Ganglionic Stimulants; D014028:Tobacco Smoke Pollution; D009538:Nicotine; D003367:Cotinine