Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour.
Prolonged maternal magnesium sulphate infusion therapy for tocolysis of premature labour may result in secondary fetal hypermagnesaemia, which has been associated with bony abnormalities in the newborn. We report on four infants, members of two twin pregnancies, who were exposed to prolonged fetal hypermagnesaemia. Three of the infants, all appropriate for gestational age, showed abnormal radiological findings consisting of abnormal mineralisation of long-bone metaphyses owing to fetal hypermagnesaemia. The fourth infant, who was growth retarded, had normal bones. Intrauterine growth restriction appears to be protective against magnesium sulphate-induced abnormal bone mineralisation in the newborn.
Department of Pediatrics, American University of Beirut Medical Center, PO Box 11-0236, Beirut, Lebanon.
Shadi N
SN
Malaeb
Adriana I
AI
Rassi
Maurice C
MC
Haddad
Muhieddine A
MA
Seoud
Khalid A
KA
Yunis
D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging / Q000209:etiology*; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D001842:Bone and Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011859:Radiography; D015145:Tocolysis / Q000009:adverse effects*; D014427:Twins
D008278:Magnesium Sulfate