Qualitative and quantitative analysis of three amino acid derivatives of anticonvulsant activity.
Qualitative and quantitative methods of analysis of three new amino-acid derivatives potential anticonvulsants of low neurotoxicity: picolinic acid benzylamide (1), nicotinic acid benzylamide (2) and isonicotinic acid benzylamide (3) were developed. Qualitative analysis includes characteristic reactions, chromatographic (TLC) investigations, IR and UV spectra interpretation. The quantitative analysis involves spectophotometric, chromatographic (HPLC) and acidimetric methods.
Pirianowicz-Chaber
Elzbieta
E
Department of Drug Chemistry, The Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, Poland.
Goldnik
Anna
A
Paruszewski
Ryszard
R
D000927:Anticonvulsants / Q000032:analysis* / Q000737:chemistry; D001593:Benzyl Compounds / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D009525:Niacin / Q000031:analogs & derivatives / Q000032:analysis / Q000737:chemistry; D010848:Picolinic Acids / Q000032:analysis / Q000737:chemistry; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods
D000927:Anticonvulsants; D001593:Benzyl Compounds; D010848:Picolinic Acids; C484798:isonicotinic acid benzylamide; C484800:nicotinic acid benzylamide; C484799:picolinic acid benzylamide; D009525:Niacin