Can we predict which children with clinically suspected pneumonia will have the presence of focal infiltrates on chest radiographs?
OBJECTIVE
To determine predictive factors for the presence of focal infiltrates in children with clinically suspected pneumonia in a pediatric emergency department.


METHODS
Children (1-16 years) with clinically suspected pneumonia were studied prospectively. The presenting features were compared between the children with and without focal infiltrates using chi2 analysis, t test, and odds ratio with 95% confidence intervals. A multivariate prediction rule was developed using logistic regression.


RESULTS
A total of 570 were studied. Risk factors (odds ratio; 95% confidence interval) for the presence of focal infiltrates included history of fever (3.1; 1.7-5.3), decreased breath sounds (1.4; 1.0-2.0), crackles (2.0; 1.4-2.9), retractions (2.8; 1.0-7.6), grunting (7.3; 1.1-48.1), fever (1.5; 1.2-1.9), tachypnea (1.8; 1.3-2.5), and tachycardia (1.3; 1.0-1.6). We then used logistic regression to develop a candidate prediction rule for the variables of fever, decreased breath sounds, crackles, and tachypnea, which had an area under the receiver operating curve of 0.668. This rule had excellent sensitivity (93.1%-98%) yet poor specificity (5.7%-19.4%).


CONCLUSIONS
Multiple predictive factors for children with suspected pneumonia have been identified. Patients with focal infiltrates were more likely in our study to have a history of fever, tachypnea, increased heart rate, retractions, grunting, crackles, or decreased breath sounds. A multivariate prediction rule shows promise for the accurate prediction of pneumonia in children. However, the prospective evaluation of this multivariate prediction rule in a clinical setting is still required.
Department of Pediatrics, Children's Hospital of Western Ontario, London, Ontario, Canada. tim.lynch@lhsc.on.ca
Tim
T
Lynch
Robert
R
Platt
Serge
S
Gouin
Charles
C
Larson
Yves
Y
Patenaude
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019091:Critical Pathways; D003661:Decision Support Techniques; D004636:Emergency Service, Hospital; D006801:Humans; D007223:Infant; D015999:Multivariate Analysis; D011014:Pneumonia / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D011859:Radiography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity