[Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm].
OBJECTIVE
To investigate the relationship between the level of transforming growth factor beta I(TGF-beta(1)) in oral and maxillofacial malignant neoplasms and the biological characteristics of these carcinoma cells.


METHODS
The level of TGF-beta(1) in the carcinoma tissue cells, human tongue squamous cell carcinoma cell line Tca8113, human minor salivary gland carcinoma cell line ACC-2 and highly metastatic adenoid cystocarcinoma cell line ACC-M was measured by ELISA KIT.


RESULTS
The level of TGF-beta(1) in the carcinoma tissue cells had significant difference to that of normal cells(P<0.01). The level in Tca8113 and ACC-2 cells was significantly higher(P<0.05). Squamous cell carcinoma cell line Tca8113 had the same level of TGF-beta(1) as the adenoid cystocarcinoma cell line ACC-2, but the highly metastatic adenoid cystocarcinoma cells(ACC-M) expressed far less compared to ACC-2 cells (P<0.01). The level of TGF-beta(1) secreted by ACC-M cells to the culture without serum was also lower than that of any of the other carcinoma cells or normal cells.


CONCLUSIONS
The level of TGF-beta(1) expression had significant relation to the proliferation, invasion and metastasis of oral and maxillofacial malignant neoplasms.
Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Qing
Q
Li
Xiao-jian
XJ
Zhou
Zhi-yuan
ZY
Zhang
Patima
Wan-tao
WT
Chen