Integrins in mammary gland development and differentiation of mammary epithelium.
Integrins are major extracellular matrix (ECM) receptors that can also serve for some cell-cell interactions. They have been identified as important regulators of mammary epithelial cell growth and differentiation. Their ability to promote cell anchorage, proliferation, survival, migration, and the induction of active ECM-degrading enzymes suggests that they play an essential role in normal mammary morphogenesis, but, on the other hand, reveals their potential to promote tumor progression.
UMR 144 CNRS-Institut Curie, Section de Recherche, 26, rue d'Ulm, 75248 Paris Cedex 05, France.
Ilaria
I
Taddei
Marisa M
MM
Faraldo
Jérôme
J
Teulière
Marie-Ange
MA
Deugnier
Jean Paul
JP
Thiery
Marina A
MA
Glukhova
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D004848:Epithelium / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism*; D009024:Morphogenesis
D016023:Integrins