Polyglutamine diminishes VEGF; passage to motor neuron death?
Altered gene transcription has been implicated in the pathogenesis of polyglutamine-dependent neurodegeneration. In this issue of Neuron, Sopher et al. demonstrate that androgen receptors containing expanded polyglutamine cause decreased expression of vascular endothelial growth factor (VEGF) by interfering with cAMP response element binding protein binding protein (CBP), thereby contributing to the motor neuron degeneration in spinal and bulbar muscular atrophy.
Katsuno
Masahisa
M
Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.
Sobue
Gen
G
D000818:Animals; D016923:Cell Death / Q000502:physiology; D006801:Humans; D009046:Motor Neurons / Q000166:cytology* / Q000502:physiology; D010455:Peptides / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology*
D010455:Peptides; D042461:Vascular Endothelial Growth Factor A; C097188:polyglutamine