Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
William E
WE
Klunk
Henry
H
Engler
Agneta
A
Nordberg
Yanming
Y
Wang
Gunnar
G
Blomqvist
Daniel P
DP
Holt
Mats
M
Bergström
Irina
I
Savitcheva
Guo-feng
GF
Huang
Sergio
S
Estrada
Birgitta
B
Ausén
Manik L
ML
Debnath
Julien
J
Barletta
Julie C
JC
Price
Johan
J
Sandell
Brian J
BJ
Lopresti
Anders
A
Wall
Pernilla
P
Koivisto
Gunnar
G
Antoni
Chester A
CA
Mathis
Bengt
B
Långström
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds / Q000097:blood / Q000737:chemistry; D001345:Autoradiography / Q000379:methods; D001665:Binding Sites; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001923:Brain Chemistry; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013844:Thiazoles / Q000097:blood / Q000737:chemistry; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods*
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18; D005947:Glucose