Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ models.
Various 3,4,5-triarylpyrroles were synthesized and evaluated for their in vivo antihyperglycemic activity in sucrose-loaded (SLM) and/or streptozotocin-induced (STZ) diabetic rat models. Three of the test compounds, 2-methyl-4,5-diphenyl-3-substituted-phenyl-1H-pyrroles (3c, d and h) showed significant inhibition on postprandial hyperglycemia in normal rats post sucrose loaded. These compounds also showed lowering of plasma glucose level in STZ-induced diabetic rat model.
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India. agoel13@yahoo.com
Atul
A
Goel
Nidhi
N
Agarwal
Fateh V
FV
Singh
Ashoke
A
Sharon
Priti
P
Tiwari
Manish
M
Dixit
Ramendra
R
Pratap
Arvind K
AK
Srivastava
Prakas R
PR
Maulik
Vishnu J
VJ
Ram
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D011758:Pyrroles / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011758:Pyrroles; D013395:Sucrose