Increased level of beta-amyloid in the brain of bulbectomized mice.
Six weeks after bilateral olfactory bulbectomy, a peptide with molecular weight of 4 kD was revealed in extracts of the neocortex and hippocampus from mice. Using monoclonal antibodies 4G8, this peptide was identified as beta-amyloid. Its level was significantly higher in the bulbectomized animals than in sham-operated mice. The bulbectomized mice displayed sharp impairment in spatial memory when tested in the Morris water maze. The results suggest that bulbectomy initiates in the brain a pathological process similar to human Alzheimer's disease in location, biochemistry, and behavioral manifestations.
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.
I Yu
IY
Aleksandrova
V V
VV
Kuvichkin
I A
IA
Kashparov
N I
NI
Medvinskaya
I V
IV
Nesterova
S M
SM
Lunin
A N
AN
Samokhin
N V
NV
Bobkova
D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001923:Brain Chemistry; D004195:Disease Models, Animal; D006624:Hippocampus / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D051379:Mice; D019579:Neocortex / Q000737:chemistry / Q000378:metabolism*; D009833:Olfactory Pathways / Q000601:surgery; D010446:Peptide Fragments / Q000032:analysis / Q000378:metabolism
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments