Prolonged neuromuscular blockade as a result of malnutrition-induced pseudocholinesterase deficiency.
Mivacurium is a short-acting neuromuscular blocking drug, ideal for short surgical procedures. The brief duration of action depends on rapid hydrolysis by plasma cholinesterase. An inherited or acquired deficiency of plasma cholinesterase can prolong the effect of mivacurium. We present an unusual case of unanticipated postoperative apnea following mivacurium administration, as a result of acquired plasma cholinesterase deficiency, in a patient with previous uneventful exposure to both mivacurium and suxamethonium (succinylcholine).
Department of Anaesthesia and Intensive Care, St. Vincent's University Hospital, Dublin, Ireland. Ahtshamniazi@hotmail.com
Ahtsham
A
Niazi
Irene E
IE
Leonard
Breda
B
O'Kelly
D000368:Aged; D001049:Apnea / Q000209:etiology; D002091:Butyrylcholinesterase / Q000172:deficiency*; D006801:Humans; D007546:Isoquinolines; D008297:Male; D044342:Malnutrition / Q000150:complications*; D000077590:Mivacurium; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents; D011183:Postoperative Complications
D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002091:Butyrylcholinesterase