Ozz; a new name on the long list of beta-catenin's nemeses.
In the February issue of Developmental Cell, Nastasi et al. describe Ozz, a muscle-specific ubiquitin ligase adaptor that regulates myofibril organization. Ozz appears to function in ubiquitination and degradation of membrane-bound, but not cytosolic, beta-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers.
Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
Geng
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Wu
Chunming
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Liu
Xi
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He
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008025:Ligases / Q000378:metabolism; D008954:Models, Biological; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009210:Myofibrils / Q000378:metabolism; D012518:Sarcomeres / Q000378:metabolism; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D051176:beta Catenin
D033942:Adaptor Proteins, Vesicular Transport; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D009124:Muscle Proteins; C483082:NEURL2 protein, human; D015534:Trans-Activators; D025801:Ubiquitin; D051176:beta Catenin; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases; D008025:Ligases