Expression array technology in the diagnosis and treatment of breast cancer.
The most common group of cancers among American women involves malignancies of the breast. Breast cancer is a complex disease, involving several different types of tissues and specific cells with various functions, that is categorized into many distinct subtypes. Microarray analysis has recently revealed that different biological subtypes of breast cancer are accompanied by differences in their specific gene expression profile. Because breast tissue (and breast cancer) is heterogeneous, microarray analysis may provide clinicians with a better understanding of how to treat each specific case. Thus, microarray analysis may translate basic research data into more confident diagnoses, specifically designed treatment regimens geared to each patient's needs, and better clinical prognoses.
Jeffrey
Stefanie S
SS
Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. ssj@stanford.edu
Fero
Michael J
MJ
Børresen-Dale
Anne-Lise
AL
Botstein
David
D
D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis