Use of intravenous polymyxin B during continuous venovenous hemodialysis.
Described here is the case of a 23-year-old male with Acinetobacter baumannii sepsis and acute renal failure requiring continuous venovenous hemodialysis treated successfully with intravenous polymyxin B. The drug was administered as a loading dose of 2.5 mg/kg, followed by 2 doses of 1 mg/kg on days 4 and 8, then 0.8 mg/kg daily to complete a 24-day course. A discussion of dosing recommendations for polymyxins in dialysis is presented.
Sarria
J C
JC
Department of Internal Medicine, Division of Infectious Diseases, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430 USA. juan.sarria@ttuhsc.edu
Angulo-Pernett
F
F
Kimbrough
R C
RC
McVay
C S
CS
Vidal
A M
AM
D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000302:isolation & purification; D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000328:Adult; D016470:Bacteremia / Q000175:diagnosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009104:Multiple Trauma / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D011112:Polymyxin B / Q000008:administration & dosage*; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D018570:Risk Assessment; D016896:Treatment Outcome
D011112:Polymyxin B