Pigmented central neurocytoma.
Central neurocytoma is a low-grade neuronal neoplasm that occurs most often within the lateral ventricles. We report the case of a 60-year-old woman who presented with gait problems, headache and memory loss. Preoperative evaluation demonstrated a heterogeneous, hypervascular and partially cystic mass in the left lateral ventricle. Histopathological examination revealed characteristic features of central neurocytoma, including immunoreactivity for synaptophysin, as well as the unusual feature of abundant pigment in the cytoplasm of tumor cells. Special stains revealed iron, consistent with hemosiderin, but found no evidence of melanin or melanosomes. Previous reports of pigmented central neurocytoma have described the presence of lipofuscin or neuromelanin. To our knowledge, the present case represents the first example of pigmented central neurocytoma secondary to hemosiderin deposition.
Department of Pathology, WRN2, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Tim-Rasmus
TR
Kiehl
Steven N
SN
Kalkanis
David N
DN
Louis
D001932:Brain Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005682:Gadolinium; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018306:Neurocytoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D010858:Pigmentation; D013194:Staining and Labeling / Q000379:methods; D016708:Synaptophysin / Q000378:metabolism
D016708:Synaptophysin; D005682:Gadolinium