Mammaglobin: a candidate diagnostic marker for breast cancer.
Mammaglobin, known for its mammary tissue specificity, has been discussed as a promising diagnostic marker in breast cancer for almost 10 years. In particular, the application of mammaglobin RT-PCR to detect disseminated breast cancer cells has been reported. More than 25 publications evaluate the detection of mammaglobin mRNA in lymph node, blood, and bone marrow specimens of breast cancer patients. Recently, structural details about the mammaglobin complex have been discovered, and these findings can be implemented to optimize detection of the secreted protein. This review summarizes the findings of almost 50 published studies and the current knowledge about the diagnostic utility of mammaglobin.
Department of Antigen Discovery, Corixa Corporation, Seattle, WA 98104, USA. zehentner@corixa.com
Barbara K
BK
Zehentner
Darrick
D
Carter
D000595:Amino Acid Sequence; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007937:Leukapheresis; D008207:Lymphatic Metastasis / Q000235:genetics; D060785:Mammaglobin A; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014598:Uteroglobin / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D060785:Mammaglobin A; D009363:Neoplasm Proteins; C556448:SCGB2A2 protein, human; D014598:Uteroglobin