Continuous melatonin treatment and fasting in the raccoon dog (Nyctereutes procyonoides)--vernal body weight regulation and reproduction.
The raccoon dog (Nyctereutes procyonoides) is a canid omnivore with marked seasonal changes in its body adiposity. The aim of this study was to investigate the roles of melatonin, leptin, ghrelin and growth hormone (GH) in weight regulation and reproduction of the species. Sixteen raccoon dogs were treated with continuous-release melatonin implants in Aug 2000 and in Feb 2001 (the MEL group) and 16 animals were sham-operated (the SHAM group). Half of the raccoon dogs were fasted between Nov 27(th) 2000 and Jan 25(th) 2001. The autumnal results have been previously published and this paper reports the vernal data. The leptin concentrations of the SHAM females were high before the mating season, decreased before estrus, increased during gestation and reduced after parturition. The MEL females had higher leptin concentrations than the SHAM females in early March, whereas the MEL males had lower leptin concentrations than the SHAM males in late March. Also the ghrelin and GH concentrations of the SHAM females decreased before estrus. Continuous melatonin treatment advanced the vernal rise in the ghrelin concentrations and the vernal drop and the subsequent rise in the GH concentrations of the females. Melatonin also increased their body mass indices from July to Aug 2001, indicating that it triggers the autumnal accumulation of fat in the species.
Mustonen
Anne-Mari
AM
Department of Biology, University of Joensuu, Finland. ammusto@cc.joensuu.fi
Nieminen
Petteri
P
Asikainen
Juha
J
Saarela
Seppo
S
Kukkonen
Jussi V K
JV
Hyvärinen
Heikki
H
D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D002335:Carnivora / Q000378:metabolism / Q000502:physiology*; D004435:Eating / Q000187:drug effects; D005215:Fasting / Q000502:physiology; D054439:Ghrelin; D013006:Growth Hormone / Q000097:blood; D020738:Leptin / Q000097:blood; D008550:Melatonin / Q000097:blood / Q000494:pharmacology*; D036361:Peptide Hormones / Q000097:blood; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology; D012621:Seasons
D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D013006:Growth Hormone; D008550:Melatonin