Stereoselective preparation of conjugated E-enynes from E-vinylic tellurides and terminal alkynes via Sonogashira cross-coupling.
E-Vinylic tellurides undergo a direct cross-coupling reaction with terminal alkynes in the presence of palladium(II)/CuI in Et(3)N at room temperature to give E-enynes in good yields. The methodology represents a general and efficient protocol for carrying out the synthesis of E-enynes under mild conditions with complete retention of configuration.
Zeni
Gilson
G
Departamento de Quimica, Laboratório de Bioquímica Toxicológica, UFSM, Santa Maria, RS, Brazil 97105-900. gzeni@quimica.ufsm.br
Alves
Diego
D
Pena
Jesus M
JM
Braga
Antonio L
AL
Stefani
Helio A
HA
Nogueira
Cristina W
CW