Ubiquitin-dependent activation of NF-kappaB: K63-linked ubiquitin chains: a link to cancer?
Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-kappaB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.
Chen
Zhijian J
ZJ
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Fuchs
Serge Y
SY
D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D006801:Humans; D051550:I-kappa B Kinase; D016328:NF-kappa B / Q000096:biosynthesis* / Q000494:pharmacology*; D009369:Neoplasms / Q000503:physiopathology*; D017346:Protein Serine-Threonine Kinases / Q000494:pharmacology; D025801:Ubiquitin / Q000494:pharmacology*
D016328:NF-kappa B; D025801:Ubiquitin; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human