A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity.
A series of novel heterocyclic analogues have been synthesized and evaluated for their ability to inhibit phenylalanyl-t-RNA synthetases and act as antibacterial agents. Several analogues have good antibacterial activity against Staphylococcus aureus.
Department of Medicinal Chemistry, Cubist Pharmaceuticals Inc., 24 Emily Street, Cambridge, MA 02139, USA. xyu@activbiotics.com
Xiang Y
XY
Yu
John
J
Finn
Jason M
JM
Hill
Zhong G
ZG
Wang
Dennis
D
Keith
Jared
J
Silverman
N
N
Oliver
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D010652:Phenylalanine-tRNA Ligase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D010652:Phenylalanine-tRNA Ligase