Cytogenetic analysis of myoepithelial cell carcinoma of salivary gland.
Myoepithelial cell carcinoma (MCC) of the salivary gland is a rare entity. Here, we describe the karyotype of MCC. The patient was a 53-year-old man, with a rapidly growing lesion of the palate. Despite complete surgical excision, radio- and chemotherapy, the lesion rapidly harboured local and distant metastases leading to the death of the patient, 4 months after the diagnosis. On histological and ultrastructural examination, the primary tumour and the related metastases were composed of oval and spindle cells, with features of myoepithelial cell differentiation reported in the literature. Cytogenetic analysis showed a composite karyotype in the primary tumour: 45-46,XY, +3[cp3]/ 44-45,XY, -17[cp4]/ 46,XY[5]. The lymph-node metastasis was near-triploid and showed a complex karyotype. Our cytogenetic data differ from those described in benign or slowly growing salivary gland tumours showing myoepithelial cell differentiation. It is suggested that highly aggressive tumours might follow a different pathway of malignant transformation.
Magrini
Elisabetta
E
Anatomia Patologica, Università di Bologna, Ospedale Bellaria, Via Altura 3, 40139 Bologna, Italy.
Pragliola
Antonella
A
Farnedi
Anna
A
Betts
Christine M
CM
Cocchi
Roberto
R
Foschini
Maria P
MP
D002135:Calcium-Binding Proteins / Q000032:analysis; D002454:Cell Differentiation; D002886:Chromosomes, Human, Pair 17; D020732:Cytogenetic Analysis; D004268:DNA-Binding Proteins; D017809:Fatal Outcome; D016147:Genes, Tumor Suppressor; D006801:Humans; D007621:Karyotyping; D007633:Keratins / Q000032:analysis; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008840:Microfilament Proteins; D008875:Middle Aged; D009006:Monosomy; D009208:Myoepithelioma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D009362:Neoplasm Metastasis / Q000473:pathology; D021362:Palate, Hard; D010750:Phosphoproteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000235:genetics* / Q000628:therapy; D015534:Trans-Activators / Q000032:analysis; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D025521:Tumor Suppressor Proteins; D000096985:Calponins
D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D007633:Keratins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D000096985:Calponins; C115051:TP63 protein, human