[HPV-associated tonsillar cancer. An update].
The major risk factors for head and neck squamous cell carcinomas (HNSCC) are considered to be tobacco and alcohol. A link between oncogenic types of the human papilloma virus (HPV) and the risk of HNSCC has been suggested in the literature. However, the causal link is now becoming more firmly established on the basis of recent analyses. About 20% of all HNSCC and more than 50% of tonsillar cancers contain HR-HPV. The causal role of HPV-infection in carcinogenesis and the molecular mechanisms involved could thus far be best elucidated in the case of cervical carcinomas. New insights and increasing evidence for the analogy of HPV-positive HNSCC with cervical cancer are discussed. The definition of HPV-positive HNSCC has become more important due to the implications for risk factors and prognosis.
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde des Klinikum der Universität zu Köln, Cologne. peter.klussmann@uni-koeln.de
J P
JP
Klussmann
S
S
Dinh
O
O
Guntinas-Lichius
C
C
Wittekindt
S
S
Weissenborn
U
U
Wieland
H P
HP
Dienes
T
T
Hoffmann
E
E
Smith
L
L
Turek
E J M
EJ
Speel
H J
HJ
Pfister
D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D015344:DNA Probes, HPV; D006801:Humans; D014066:Palatine Tonsil / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000821:virology*; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014067:Tonsillar Neoplasms / Q000473:pathology / Q000821:virology*; D014774:Virulence
D015344:DNA Probes, HPV