[Sentinel lymph nodes detection in patients with cervical cancer undergoing radical hysterectomy].
OBJECTIVE
To investigate the feasibility of sentinel lymph node (SLN) detection in patients with cervical cancer undergoing radical hysterectomy.


METHODS
Twenty patients with cervical cancer at stage Ib (n = 3), stage IIa (n = 12) and stage IIb (n = 5) underwent SLNs detection by using blue dye. Four ml of methylene blue or lymphazurin was injected into the cervix at 4 points around the tumor at the time of radical hysterectomy and bilateral pelvic lymphadenectomy. Tumor characteristics, surgical findings, and specific locations of lymphatic dye uptake were recorded and correlated with final pathology results.


RESULTS
Among 20 patients underwent this detection, dye uptake was seen in 18 patients. Total number of SLNs were 33. Eighteen SLNs identified located in right pelvic and 15 SLNs located in left. The SLNs were successfully detected in 78% patients (14/18). Six patients (33%) were diagnosed with lymph node metastases and there were 5 patients with positive nodes in the group of SLN. Two patients had both positive SLNs and pelvic lymph nodes. Three patients had positive SLNs only. The predictive rate was 100% and the false-negative rate was zero.


CONCLUSIONS
SLN detection undergoing radical hysterectomy is feasible and safe, however, the detection rate of SLN needs improvement.
Department of Gynecologic Oncology, Cancer Hospital, Fudan University, Shanghai 200032, China.
Hua-ying
HY
Wang
Jian-min
JM
Sun
Jie
J
Tang
D000328:Adult; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*