[Effect of perftoran on the oxidant-antioxidant system in patients with severe trauma and blood loss].
Diminution of reperfusion and re-oxygenation lesions is an important task in the treatment of patients with severe injury and blood loss. From this standpoint the influence of perforan on the condition of the oxidant-antioxidant system was studied in patients with severe combined trauma. The application of perftoran in the early post-trauma period was found to intensify the processes of lipid peroxidation and, simultaneously, to normalize the parameters of the antioxidant-protection system.
Ostapchenko
D A
DA
Radaev
S M
SM
Gerasimov
L V
LV
Nemtsova
E R
ER
Sergeeva
T V
TV
Vlasenko
A V
AV
D018806:APACHE; D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism; D003102:Colloids / Q000008:administration & dosage; D000077324:Crystalloid Solutions; D017707:Erythrocyte Transfusion; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D006470:Hemorrhage / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007263:Infusions, Parenteral; D007552:Isotonic Solutions; D007781:Lactoferrin / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009104:Multiple Trauma / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D010951:Plasma Exchange; D010952:Plasma Substitutes / Q000008:administration & dosage; D015599:Trauma Severity Indices; D016896:Treatment Outcome
D003102:Colloids; D000077324:Crystalloid Solutions; D005466:Fluorocarbons; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D008315:Malondialdehyde; C063334:perftoran; D002570:Ceruloplasmin; D007781:Lactoferrin