[IgA nephropathy].
IgA nephropathy is quite a common disease with an annual incidence around 25 per 10(6) inhabitants. It occurs in young adults and its progression is rather indolent, leading to a 20-30% incidence of end stage renal failure within 20 years of evolution. Gross hematuria is classic but far less frequent than microscopic hematuria or proteinuria. Therefore, routine screening remains essential. It is still very difficult to establish the eventual outcome and patients must remain under medical control for a lifetime. The amount of proteinuria, arterial hypertension and pathological damage are the major prognostic factors. The control of first two should be a permanent goal of the treatment, in which ACE inhibitors or angiotensin II receptor antagonists play a central role. High-risk patients will benefit from steroid and immunosuppressive therapy.
Alamartine
Eric
E
Service de néphrologie, dialyse et transplantation rénale, hôpital Nord, 42055 Saint-Etienne Cedex 02. eric.alamartine@chu-st-etienne.fr
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000367:Age Factors; D000804:Angiotensin II / Q000037:antagonists & inhibitors; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology; D012307:Risk Factors; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D007166:Immunosuppressive Agents; D000804:Angiotensin II