The synthesis and anticonvulsant activity of some omega-phthalimido-N-phenylacetamide and propionamide derivatives.
In this study, by combining anilide and N', N'-phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen omega-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2, 6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that omega-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure.
Soyer
Zeynep
Z
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University Bornova, Izmir 35100, Turkey.
Kilic
Fatma Sultan
FS
Erol
Kevser
K
Pabuccuoglu
Varol
V
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000577:Amides / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D051379:Mice; D012640:Seizures / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000081:Acetamides; D000577:Amides; D000927:Anticonvulsants; C034666:propionamide