A review of antidepressant-induced hypomania in major depression: suggestions for DSM-V.
OBJECTIVE
To determine if the classification of 'antidepressant-induced hypomania' in DSM-IV is supported by available data.


METHODS
We reviewed the available scientific literature to examine the incidence of mania and hypomania in non-bipolar patients who were treated with antidepressants.


RESULTS
Eighty-nine per cent of studies of antidepressants in major depressive disorder patients reported no cases of treatment-induced hypomania. No instances of treatment-induced hypomania were reported in three large studies of patients with chronic forms of depression.


CONCLUSIONS
The rate of antidepressant-induced hypomania in major depressive disorder is within the rate of misdiagnosis of bipolar depression as unipolar. Depressed patients who experience antidepressant-associated hypomania are truly bipolar.
Department of Psychiatry and Behavioral Science, Center for Anxiety and Depression, University of Washington, Seattle, WA 98105, USA.
Benjamin J D H
BJ
Chun
David L
DL
Dunner
D000928:Antidepressive Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans
D000928:Antidepressive Agents