Different evolutionary pathway of B*570101 and B*5801 (B17 group) alleles based in intron sequences.
Two theories about MHC allele generation have been put forward: (1) point mutation diversification and/or (2) gene conversion events. A model supporting the existence of both of these mechanisms is shown in this paper; the possible evolution of the HLA-B*570101 and HLA-B*5801 alleles (which belong to the HLA-B17 serology group) is studied. The hypothesis favoured is that gene conversion events have originated these alleles, because intron sequences are also analysed. Evolution by point mutation should only be accepted if flanking introns have also been sequenced.
Martinez-Laso
Jorge
J
Department of Immunology, Universidad Complutense Hospital, 28040 Madrid, Spain.
Moscoso
Juan
J
Zamora
Jorge
J
Martin-Villa
Manuel
M
Lowy
Ernesto
E
Vargas-Alarcon
Gilberto
G
Serrano-Vela
Juan Ignacio
JI
Gomez-Casado
Eduardo
E
Arnaiz-Villena
Antonio
A
D000483:Alleles; D001483:Base Sequence; D018076:DNA, Complementary; D019143:Evolution, Molecular; D005785:Gene Conversion; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000145:classification / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D012689:Sequence Homology, Nucleic Acid; D015398:Signal Transduction
D018076:DNA, Complementary; D015235:HLA-B Antigens; C037449:HLA-B17 antigen