Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers.
This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-beta-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with commercial tablets. Administration of macrogol suppositories did not result in measurable plasma concentrations of albendazole sulfoxide.
Department of Clinical Pharmacy, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
I M
IM
Rigter
H G
HG
Schipper
R P
RP
Koopmans
H J M
HJ
van Kan
H W
HW
Frijlink
P A
PA
Kager
H-J
HJ
Guchelaar
D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000871:Anthelmintics; D013607:Tablets; D015766:Albendazole