Antileishmanial activity of a new 8-hydroxyquinoline derivative designed 7-[5'-(3'-phenylisoxazolino)methyl]-8-hydroxyquinoline: preliminary study.
7-[5'-(3'-phenylisoxazolino)methyl]-8-hydroxyquinoline a new synthetic 8-hydroxyquinoline derivative, was found, for the first time, to inhibit the multiplication in vitro of Leishmania tropica, Leishmania major and Leishmania infantum at micromolar concentrations. For each test we calculated a 50% inhibitory concentration (IC50) and the IC50 values found after 48 h are: 0.4 microgram/ml for L. tropica, 0.88 microgram/ml for L. major and 0.62 microgram/ml for L. infantum. As positive control, amphotericin B, a standard antileishmanial drug was used.
Département de Biologie, Laboratoire de Microbiologie et Biologie Moléculaire, Faculté des Sciences Ben M'sik-Casablanca, Université Hassan II-Mohammedia, Sidi Othmane, Casablanca B.P. 7955, Morocco. dzainaba@yahoo.fr
Zainaba
Z
Dardari
Meryem
M
Lemrani
Abdelmejid
A
Bahloul
Abdelfatah
A
Sebban
Mohammed
M
Hassar
Said
S
Kitane
Mohammed
M
Berrada
Mohammed
M
Boudouma
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D018314:Leishmania infantum / Q000187:drug effects / Q000254:growth & development; D018320:Leishmania major / Q000187:drug effects / Q000254:growth & development; D007895:Leishmania tropica / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared
C485661:7-(5'-(3'-phenylisoxazolino)methyl)-8-hydroxyquinoline; D000981:Antiprotozoal Agents; D006912:Hydroxyquinolines; D007202:Indicators and Reagents; D000666:Amphotericin B