[Intercepting effects of seven Chinese herb drugs on experimental oral carcinogenesis].
OBJECTIVE
To screen effective chemopreventive Chinese herb drugs on experimental oral carcinogenesis.


METHODS
410 golden hamsters were randomly divided into positive control group,negative control group and 7 experimental groups(Radix et Rhizoma Thalictri, Radix Sophorae Tonkinesis, Pseudobulbus Cremastrae appendiculate, Rhizoma Acori Tatarinowii, Radix Angelicae seu Heraclei, Rhizoma Curcumae, Fructus Trichosanthis). 7,12-Dimethylbenz(a)anthracene(DMBA) was used to induce oral carcinogenesis in hamster cheek pouch, 7 liquid Chinese herb drugs were respectively injected into the stomach of the hamsters before and during oral carcinogenesis. Specimens were observed by histopathologic method, and the results were analysized statistically.


RESULTS
Compared with positive control group, the prevalence of displasia was significantly reduced in group Radix Sophorae Tonkinesis and Radix Angelicae Dahuricae, but significant decrease could not be found in other experiment groups.


CONCLUSIONS
Radix Sophorae Tonkinesis and Radix Angelicae Dahuricae could effectively intercept DMBA-induced oral carcinogenesis in hamster.
Department of Oral Medicine, Shanghai Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Wei-xin
WX
Zhang
Hui-fang
HF
Hu
Wei-guo
WG
Li
Zeng-tong
ZT
Zhou
D000818:Animals; D006224:Cricetinae; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008647:Mesocricetus; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004365:Drugs, Chinese Herbal