[Metachronous bilateral ureteral cancer in patient with hereditaly nonpolyposis colorectal cancer].
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder characterized by an excess of extracolonic malignancies including those of the urinary tract. We report a case of metachronous bilateral ureteral cancer associated with HNPCC. A 51-year-old man was referred to Nara National Hospital for further examination of left hydronephrosis on excretory urography performed on the periodical follow-up for colon cancer. Computed tomography showed a mass in the left lower ureter and urine cytology was demonstrated class V. The operation was performed under the diagnosis of left ureteral cancer. The histopathological diagnosis was transitional cell carcinoma, grade 2, pT1. After 4 months of the operation, he presented with gross hematuria. Retrograde pyelography demonstrated tumors in the right side (ureter and renal pelvis) and the histopathological diagnosis of the biopsy specimens revealed transitional cell carcinoma, grade 2. We performed 4 times of BCG instillation followed by laser ablation of the tumor. The reported case was compatible for Japanese clinical criteria, group B for HNPCC.
Department of Urology, Nara National Hospital, Nara Medical University.
Masashi
M
Yamamoto
Hiroki
H
Kashiwai
Naoya
N
Hirata
Hisashi
H
Matsuki
Kazuhiro
K
Shimizu
Nobumichi
N
Tanaka
Seiichiro
S
Ozono
D000283:Administration, Intravesical; D001500:BCG Vaccine / Q000008:administration & dosage; D002295:Carcinoma, Transitional Cell / Q000209:etiology* / Q000628:therapy; D017115:Catheter Ablation; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D004268:DNA-Binding Proteins; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology* / Q000628:therapy; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D051718:MutS Homolog 2 Protein; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000628:therapy; D010375:Pedigree; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014516:Ureteral Neoplasms / Q000209:etiology* / Q000628:therapy
D001500:BCG Vaccine; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein