Control of proliferation by Bcl-2 family members.
The anti-proliferative effect of Bcl-2 acts mainly at the level of the G0/G1 phase of the cell cycle. Deletions and point mutations in the bcl-2 gene show that the anti-proliferative activity of Bcl-2, can in some cases, be dissociated from its anti-apoptotic function. This indicates that the effect of Bcl-2 on cell cycle progression can be a direct effect and not only a consequence of its anti-apoptotic activity. Bcl-2 appears to mediate its anti-proliferative effect by acting on both signal transduction pathways (NFAT, ERK) and on specific cell cycle regulators (p27, p130).
INSERM U503, Centre d'étude et de Recherche en Virologie et Immunologie, 21 Avenue Tony Garnier 69365 Lyon Cedex 07, France.
Nathalie
N
Bonnefoy-Berard
Abdel
A
Aouacheria
Claire
C
Verschelde
Laurence
L
Quemeneur
Antoine
A
Marçais
Jacqueline
J
Marvel
D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
D018797:Cell Cycle Proteins; D019253:Proto-Oncogene Proteins c-bcl-2