Synergistic activities of moxifloxacin combined with piperacillin-tazobactam or cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii clinical isolates.
The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. rose-jung@uchsc.edu
Rose
R
Jung
Maroof
M
Husain
Michael K
MK
Choi
Douglas N
DN
Fish
D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004357:Drug Synergism; D016972:Enterobacter cloacae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D000077266:Moxifloxacin; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D000078142:Tazobactam
D000890:Anti-Infective Agents; D001372:Aza Compounds; D002511:Cephalosporins; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D010406:Penicillins; D011804:Quinolines; D000077723:Cefepime; D010397:Penicillanic Acid; D000078142:Tazobactam; D000077266:Moxifloxacin; D010878:Piperacillin