Cavum septum pellucidum and its increased prevalence in schizophrenia: a neuroembryological classification.
Thirty-two female (mean age=52.9 years [SD=9.2]) patients with a diagnosis of residual schizophrenia and 19 female (mean age=51.1 years [SD=12.7]) control subjects were studied through cerebral Magnetic Resonance Imaging. Along the entire surface of the septum pellucidum, 1-mm coronal slices were performed in all subjects. The authors classified the cavum septum pellucidum into three types based on embryological development. The prevalence of a cavum was significantly higher in the patients with schizophrenia (Chi square 6.112. p < 0.05). No other significant associations with previously described morphological brain changes were found. Although this result was found in previous reports (DeGreef et al., 1992; DeLisi et al., 1993), our discussion focused on the neurodevelopmental theory of the septum pellucidum and its possible association with schizophrenia.
Galarza
Marcelo
M
Department of Anatomy, School of Medicine, University of Salvador, Buenos Aires, Argentina. galarzamarcelo@hotmail.com
Merlo
Alicia B
AB
Ingratta
Adriana
A
Albanese
Eduardo F
EF
Albanese
Alfonso M
AM
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000453:epidemiology* / Q000473:pathology; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000196:embryology; D013997:Time Factors