Intraoperative administration of nitric oxide.
Despite its therapeutic efficacy in various clinical scenarios in the intensive care unit setting, there are limited reports regarding the intraoperative applications of nitric oxide (NO). The authors present 2 pediatric patients to whom inhaled NO was administered intraoperatively. In one patient, NO was used to treat hypoxemia that developed after the institution of one-lung ventilation during thoracoscopic resection of a bronchiectatic section of lung. In the second patient, NO was used to alleviate pulmonary hypertension and cardiovascular dysfunction with pulmonary artery cross-clamping for placement of a modified Blalock-Taussig shunt. The potential intraoperative applications and techniques for the intraoperative delivery of NO are presented.
Dietrich
Cassie C
CC
Department of Child Health, The University of Missouri, Columbia 65212, USA.
Tobias
Joseph D
JD
D000280:Administration, Inhalation; D001987:Bronchiectasis / Q000150:complications / Q000601:surgery; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications; D018610:Heart Bypass, Right / Q000009:adverse effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D000860:Hypoxia / Q000188:drug therapy* / Q000209:etiology; D007231:Infant, Newborn; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D016343:Monitoring, Intraoperative / Q000379:methods; D009569:Nitric Oxide / Q000627:therapeutic use*; D018579:Patient Selection; D018633:Pulmonary Atresia / Q000150:complications / Q000601:surgery; D012121:Respiration, Artificial / Q000009:adverse effects; D013906:Thoracoscopy / Q000009:adverse effects; D016896:Treatment Outcome
D001993:Bronchodilator Agents; D009569:Nitric Oxide