Synergistic activities of moxifloxacin combined with piperacillin-tazobactam or cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii clinical isolates.
The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.
Jung
Rose
R
Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA. rose-jung@uchsc.edu
Husain
Maroof
M
Choi
Michael K
MK
Fish
Douglas N
DN
D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004357:Drug Synergism; D016972:Enterobacter cloacae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D000077266:Moxifloxacin; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*; D000078142:Tazobactam
D000890:Anti-Infective Agents; D001372:Aza Compounds; D002511:Cephalosporins; D004791:Enzyme Inhibitors; D024841:Fluoroquinolones; D010406:Penicillins; D011804:Quinolines; D000077723:Cefepime; D010397:Penicillanic Acid; D000078142:Tazobactam; D000077266:Moxifloxacin; D010878:Piperacillin