Fragmentation studies on tetronasin by accurate-mass electrospray tandem mass spectrometry.
We report here the first full fragmentation study of tetronasin 1. Fragmentation was carried out by high-resolution ESI-CID-MS(n). The formulae of the fragment ions were determined by accurate mass measurements. It is demonstrated that the fragmentation routes observed derive essentially from a first loss of water via two different mechanisms. One minor route consists of a charge remote neutral loss and the second major route occurs via the formation of a carbocation. The fragments obtained from this carbocation were produced by subsequent complex neutral eliminations and the structures were inferred, in some cases, by carbocation stability.
Fonseca
Tatiana
T
Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Lopes
Norberto P
NP
Gates
Paul J
PJ
Staunton
James
J
D000900:Anti-Bacterial Agents / Q000737:chemistry; D002138:Calibration; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*; D013291:Streptococcus / Q000737:chemistry
D000900:Anti-Bacterial Agents; D005663:Furans; C055416:tetronasin