[Experimental and clinical research on the effect of keyouling on condyloma acuminatum and adjustment of cellular immunity function].
OBJECTIVE
To discuss the mechanism of the traditional Chinese medicine Keyouling oral liquid in the treatment of condyloma acuminatum(CA) and the adjustment of cellular immunity function.


METHODS
The IL-18 and TNF-alpha levels of peripheral serum and wart tissue of patterned rats and CA patients exposed to Keyouling were determined by means of double-antibody sandwich ELISA, and the NK cellular activity of the spleen of the patterned rats and that of the peripheral blood of the CA patients exposed to Keyouling were determined by means of 3H-TdR isotype release.


RESULTS
The IL-18 and TNF-alpha levels, the NK cellular activity of the high-dosage group showed significant difference from those of the pattern group and low-dosage group in animal experiment(P < 0.05); the IL-18 and TNF-alpha levels of peripheral serum and wart tissues, and the NK cellular activity of the peripheral blood of the treatment group showed significant difference from those of the control group after treatment(P < 0.01, P < 0.05).


CONCLUSIONS
Keyouling oral liquid has significant positive adjusting effect, which can markedly ameliorate the cellular immunadeficiency of the patterned animals and reinforce the cellular immunocompetence of CA patients.
Jiang
Yi
Y
Andrology Department, General Hospital of Pangang Group, Panzhihua, Sichuan 617023, China.
Wan
Kaicheng
K
Wang
Caiming
C
Wang
Ping
P
Chen
Yancai
Y
Zeng
Xiangwen
X
Zhang
Shuwu
S
D000293:Adolescent; D000328:Adult; D000818:Animals; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D020382:Interleukin-18; D014409:Tumor Necrosis Factor-alpha