Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas.
The authors evaluated a new stereotactic radiosurgical approach in seven patients with gelastic epilepsy due to hypothalamic hamartomas. Stereotactic implantation of 125I-seeds into the hamartoma was feasible in six patients. At follow-up at least 1 year after interstitial radiotherapy, two patients had become seizure-free within 2 months, and two others had only persisting auras. There were no major perioperative or postoperative side effects.
Epilepsy Center, University Clinics of Freiburg, Germany. schulzeb@nz.ukl.uni-freiburg.de
A
A
Schulze-Bonhage
V
V
Homberg
M
M
Trippel
R
R
Keimer
C E
CE
Elger
P C
PC
Warnke
C
C
Ostertag
D000293:Adolescent; D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D002648:Child; D004343:Drug Implants; D004351:Drug Resistance; D004828:Epilepsies, Partial / Q000209:etiology / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006222:Hamartoma / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D016634:Radiosurgery / Q000379:methods; D016896:Treatment Outcome
D004343:Drug Implants; D007457:Iodine Radioisotopes