Identification of a Mycobacterium tuberculosis strain with stable, low-level resistance to isoniazid.
We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (-15) --> T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.
Madison
Bereneice M
BM
Division of Laboratory Systems, Public Health Practice Program Office, Centers for Disease Control Prevention, Atlanta, Georgia 30341, USA. bdm6@cdc.gov
Siddiqi
Salman H
SH
Heifets
Leonid
L
Gross
Wendy
W
Higgins
Mike
M
Warren
Nancy
N
Thompson
Anthony
A
Morlock
Glenn
G
Ridderhof
John C
JC
D000962:Antimalarials / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D024881:Drug Resistance, Bacterial / Q000502:physiology*; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D016366:Open Reading Frames / Q000235:genetics; D014376:Tuberculosis / Q000382:microbiology
D000962:Antimalarials; D004269:DNA, Bacterial; D007538:Isoniazid