Regulation of transcriptional coactivator PGC-1alpha.
Transcriptional coregulators modulate the activity of transcription factors and are required for the proper regulation of gene expression. One transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), plays an important role in the control of energy metabolism and has been associated with type 2 diabetes. A recent paper by Fan et al. provides new information about the posttranslational regulation of PGC-1alpha activity. This Perspective discusses the implications of these findings with respect to diabetes and aging.
Melloul
Danielle
D
Department of Endocrinology at Hadassah University Hospital, Jerusalem 91120, Israel.
Stoffel
Markus
M
D000818:Animals; D006801:Humans; D011499:Protein Processing, Post-Translational; D014157:Transcription Factors / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*
D014157:Transcription Factors; C111264:peroxisome-proliferator-activated receptor-gamma coactivator-1