Synthesis of 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides.
Novel racemic 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4-oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid.
Pharmasset Inc., 1860 Montreal Road, Tucker, GA 30084, USA. jdu@pharmasset.com
Jinfa
J
Du
Steven
S
Patterson
Junxing
J
Shi
Byoung-Kwon
BK
Chun
Lieven J
LJ
Stuyver
Kyoichi A
KA
Watanabe
D004148:Dioxolanes / Q000138:chemical synthesis*; D009705:Nucleosides / Q000138:chemical synthesis*
D004148:Dioxolanes; D009705:Nucleosides