[In situ expression of transforming growth factor beta 1 in the process of induction chemotherapy for oral squamous cell carcinoma].
OBJECTIVE
To study the differential expression of transforming growth factor beta 1 (TGF beta 1) in oral carcinoma and stroma lymphocytes by induction chemotherapy and inquire into the mechanism of TGF beta 1 information transmission.


METHODS
Forty cases of oral tumor were treated with MTX, CDDP and PYM via subcutaneous implantable drug pump, in situ hybridization method was adopted to detect the expression of TGF beta 1 mRNA.


RESULTS
The positive expression of TGF beta 1 mRNA was enhanced in oral carcinoma (P < 0.05). After the induction chemotherapy via subcutaneous implantable drug pump, not only the expression level of TGF beta 1 in malignant cells of invading front zone was up-regulated (P < 0.05), but the expression level of stroma lymphocytes was higher than before.


CONCLUSIONS
These data demonstrated that TGF beta 1 not only has transforming potential, but also enhances the malignant progression of oral carcinoma. It was clear that TGF beta 1 can act as a tumor suppressor and a significant stimulator of T-cell-mediated tumor cytotoxity as well.
Tang
Wei
W
West China Stomatological Hospital, Sichuan University, Chengdu 610041, China.
Tian
Wei-dong
WD
Li
Sheng-wei
SW
Tang
You-chao
YC
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D053773:Transforming Growth Factor beta1
D012333:RNA, Messenger; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D001761:Bleomycin; C021771:zhengguangmycin; D016190:Carboplatin; D008727:Methotrexate