Plasma carnitine concentrations in patients undergoing open heart surgery.
Carnitine is an essential cofactor for fatty acid (FA) metabolism, the predominant source of ATP in the normal aerobic heart. During myocardial ischemia, FA metabolism is impaired and tissue carnitine levels are depleted. Since the heart cannot synthesize carnitine, plasma carnitine could play an important role in maintaining myocardial carnitine levels during reperfusion. The purpose of this study was to determine the incidence of abnormal plasma carnitine concentrations in open heart surgery. Blood samples were obtained from eleven patients before, immediately after, and two hours after cardiopulmonary bypass (CPB). Total and free carnitine levels were significantly reduced immediately after CPB (p<0.01) and remained depressed until two hours after CPB (p<0.01 vs. pre CPB), while acyl carnitine levels were unchanged over the course of this study. These depressed free carnitine levels might affect cardiac metabolism in the heart after open heart surgery. Carnitine supplement might be a useful adjunct in the therapy after open heart surgery.
Department of Cardiovascular Surgery, Seirei Hamamatsu General Hospital, Shizuoka, Japan.
Shintaro
S
Nemoto
Kiyomitsu
K
Yasuhara
Katsutoshi
K
Nakamura
Yutaka
Y
Miyoshi
Akira
A
Sakai
D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002331:Carnitine / Q000097:blood*; D005260:Female; D006331:Heart Diseases / Q000097:blood* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D019990:Perioperative Care; D013997:Time Factors
D002331:Carnitine