Clinical and immunological findings of two siblings in a family with generalized aggressive periodontitis.
OBJECTIVE
The clinical and immunological data from 2 siblings with generalized aggressive periodontitis in a family are presented.


METHODS
Peripheral blood lymphocyte subpopulations were analyzed by dual color flow cytometry by using monoclonal antibodies for the lymphocyte receptors CD2, CD3, CD4, CD5, CD8, CD16, CD19, CD11b, CD11c, and HLA-DR.


RESULTS
Both patients showed a higher increase in CD11b/CD18 expression.


CONCLUSIONS
The evaluation of CD11b and CD11c receptors may be important in explaining leukocyte abnormalities in the pathogenesis of the disease. One of the patients showed decreased counts of natural killer cells while the other was normal. In both patients, the authors observed a slight elevation in Ts lymphocytes.
Aren
Gamze
G
Department of Pedodontics, School of Dentistry, University of Istanbul, Turkey. gamzearen@hotmail.com
Gürel
Nuray
N
Yalçin
Funda
F
Firatli
Erhan
E
D018941:Antigens, CD19 / Q000032:analysis; D039481:CD11b Antigen / Q000032:analysis; D039521:CD11c Antigen / Q000032:analysis; D018801:CD2 Antigens / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002648:Child; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D010518:Periodontitis / Q000235:genetics* / Q000276:immunology; D017452:Receptors, IgG / Q000032:analysis
D018941:Antigens, CD19; D039481:CD11b Antigen; D039521:CD11c Antigen; D018801:CD2 Antigens; D017252:CD3 Complex; D015704:CD4 Antigens; D018956:CD5 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D017452:Receptors, IgG