Biomimetic studies on anti-thyroid drugs and thyroid hormone synthesis.
The selenium analogues of anti-thyroid drugs exhibit their anti-thyroid action by a mechanism different from that of MMI. The selenium analogue of MMI and related selenium compounds exhibit high GPx activity, providing a novel method for the reversible inhibition of thyroid hormone biosynthesis.
Roy
Gouriprasanna
G
Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India.
Nethaji
Munirathinam
M
Mugesh
G
G
D013956:Antithyroid Agents / Q000737:chemistry* / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology; D007453:Iodide Peroxidase / Q000037:antagonists & inhibitors; D007700:Kinetics; D007784:Lactoperoxidase / Q000037:antagonists & inhibitors; D008713:Methimazole / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013963:Thyroid Hormones / Q000096:biosynthesis*
D013956:Antithyroid Agents; D016566:Organoselenium Compounds; D013963:Thyroid Hormones; D008713:Methimazole; D007784:Lactoperoxidase; D007453:Iodide Peroxidase