Synthesis and in vitro evaluation of 7-dialkylaminomethylbenzo[g]quinoxaline-5,10-diones.
A series of benzo[g]quinoxaline-5,10-dione derivatives carrying a 7-dialkylaminomethyl substituent was synthesized and their in vitro cytotoxic activities were evaluated against four human cancer cell lines (HCT-15, SK-OV-3, MD-MB-468 and T-47D). The most active compound 9d showed cytotoxic activity comparable to that of doxorubicin against HCT-15 cancer cell line.
Lee
Heesoon
H
College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea. medchem@chungbuk.ac.kr
Cho
Sungmoon
S
Namgoong
Kwon
K
Jung
Jae-Kyung
JK
Cho
Jungsook
J
Yang
Sung-Il
SI
D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology*
D011810:Quinoxalines