Amlodipine-induced immune thrombocytopenia.
OBJECTIVE
Drug-induced thrombocytopenia is a serious, but rare, side-effect of treatment with a number of drugs. In this report, we investigate the suspicion that amlodipine, a calcium-channel blocker, was responsible for immune thrombocytopenia in a 79-year-old patient.


METHODS
Our patient experienced two attacks of thrombocytopenic purpura after 10 years of treatment with amlodipine. Antibodies to platelets were tested by standard methods.


RESULTS
Initially, the platelet count increased owing to treatment with prednisolone and intravenous immunoglobulin G, but decreased shortly after discontinuation of this treatment. The patient's serum was found to contain amlodipine-dependent antibodies to platelets, and he recovered after stopping the drug.


CONCLUSIONS
Amlodipine can induce immune thrombocytopenia, which may strongly resemble autoimmune thrombocytopenia.
Institute of Clinical Pharmacology, Charité-University Medicine, Humboldt-University Berlin, Germany.
E
E
Garbe
O
O
Meyer
F
F
Andersohn
T
T
Aslan
H
H
Kiesewetter
A
A
Salama
D000368:Aged; D017311:Amlodipine / Q000009:adverse effects* / Q000276:immunology; D000906:Antibodies / Q000097:blood; D001792:Blood Platelets / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis; D013921:Thrombocytopenia / Q000139:chemically induced / Q000175:diagnosis / Q000276:immunology*
D000906:Antibodies; D017311:Amlodipine