C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation.
The present work reports the DNA sequence of the polymorphic region from the uncommon complement allele C4B93. It shows a new combination of Chido and Rodgers antigenicities and expresses reverse antigenicity because it carries Rodgers 1, 2, and 3. C4B93 could have arisen from an ancient, non-homologous recombination between C4A3 (or C4A6) and C4B1a or from a homologous recombination between C4B1a and C4B5. These events would be enhanced by the presence of recombination promoting Escherichia colichi-like signals in the fragment between positions 1157 and 1186. The generation of the C4 polymorphism by recombination would explain the concerted evolution of C4 genes in primates.
Service of Immunology, Hospital '12 de Octobre' Madrid, Spain. epaz@h12o.es
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López-Goyanes
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Moreno
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Ferre
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Paz-Artal
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D003181:Complement C4 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic / Q000235:genetics*
D003181:Complement C4