A new HLA-DRB1*11 allele, DRB1*1144, identified by cloning and sequencing.
We report here the identification of a novel DRB1*11 allele, DRB1*1144, identified during sequence-based HLA-DRB1 typing. Molecular cloning and direct sequencing confirmed that the new allele is identical to DRB1*110401 at exon 2, except for a single nucleotide substitution (GTG-->GCG) changing codon 38 from Valine to Alanine.
Laboratorio di Ricerca di Onco-Ematologia, Dipartimento di Onco-Ematologia, Azienda Ospedale 'San Salvatore', Pesaro, Italy. s.nesci@ospedalesansalvatore.it
S
S
Nesci
O
O
Buffi
A
A
Iliescu
M
M
Luchetti
M R
MR
Battarra
M
M
Amadei
G
G
Visani
M
M
Andreani
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D019976:Cloning, Organism; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D016415:Sequence Alignment
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains