Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units.
OBJECTIVE
To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.


METHODS
Prospective observational study.


METHODS
Medical intensive care unit at a university hospital.


METHODS
Fourteen patients hospitalised in a medical intensive care unit.


METHODS
Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.


RESULTS
Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m(2) was significantly better than that of creatinine ( p<0.05).


CONCLUSIONS
Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.
Delanaye
Pierre
P
Nephrology, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000 Liege, Belgium.
Lambermont
Bernard
B
Chapelle
Jean-Paul
JP
Gielen
Jacques
J
Gerard
Paul
P
Rorive
Georges
G
D003404:Creatinine / Q000097:blood*; D003422:Critical Care; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine