New oligomers of conduritol-F and muco-inositol. Synthesis and biological evaluation as glycosidase inhibitors.
Several oligomers possessing the configuration of conduritol-F and muco-inositol have been prepared and tested against six glycosidase enzymes. Electrochemical dehalogenation and reductive deprotection of cinnamyl ethers are featured in the reported syntheses. The synthesis, properties, and biological activities are investigated.
Freeman
Stanley
S
Department of Chemistry, University of Florida, PO Box 117200, Gainesville, FL 32611, USA.
Hudlicky
Tomas
T
D004353:Drug Evaluation, Preclinical / Q000379:methods; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D007294:Inositol / Q000138:chemical synthesis* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D005960:Glucosides; D011480:Protease Inhibitors; C417483:conduritol F; D007294:Inositol; D006026:Glycoside Hydrolases