Bone mineral density in adolescent females using depot medroxyprogesterone acetate.
OBJECTIVE
To examine bone mineral density (BMD) on a semi-annual basis among control subjects and adolescent females receiving depot medroxyprogesterone acetate (DMPA) injection or oral contraceptives.


METHODS
Non-randomized prospective study.


METHODS
Teenage pregnancy prevention intervention clinic.


METHODS
Adolescent females who were new users of DMPA injection (N=58, age 12-21) or the oral contraceptive pill (N=71, age 11-19) and normal menstruating girls (N=19, age 15-18).


METHODS
Baseline and 6-monthly measures of lumbar vertebral BMD using dual-energy X-ray absorptiometry over a 2-year period.


METHODS
comparison of percent change on BMD over time between DMPA users, pill users, and normal menstruating girls.


RESULTS
There was no difference on group characteristics at baseline except for the ethnicity between the controls and the DMPA group. There was a statistically significant decrease in BMD between DMPA users and controls at 6 months (-3.02% change, P=0.014) 12 months (-3.38% change, P=0.001) 18 months (-4.81% change, P<0.001) and 24 months (-6.81% change, P=0.010). There was no statistical difference between pill users and controls.


CONCLUSIONS
There is a relationship between DMPA use and a decrease in BMD compared to normal menstruating controls that seems to persist up to 24 months.
Lara-Torre
Eduardo
E
Kaza Medical Group, 113 Neurology Way, Milford, DE 19963, USA. elaratorre@yahoo.com
Edwards
Catherine P
CP
Perlman
Sally
S
Hertweck
S Paige
SP
D015502:Absorptiometry, Photon; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D015519:Bone Density / Q000187:drug effects*; D002648:Child; D003271:Contraceptive Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007267:Injections; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies
D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate