Effect of combined statin and beta-blocker treatment on one-year morbidity and mortality after acute myocardial infarction associated with heart failure.
This retrospective, nonrandomized analysis evaluated the effect of initiating statin or beta-blocker treatment early in the course of heart failure developed during acute myocardial infarction compared with the effect of neither or both treatments. Early initiation of statins or beta blockers alone was associated with improved event-free survival, and the benefits of the combined treatment were additive.
Department of Cardiology, Rikshospitalet, University of Oslo, Oslo, Norway. ina.hognestad@klinmed.uio.no
Aina
A
Hognestad
Kenneth
K
Dickstein
Eivind
E
Myhre
Steven
S
Snapinn
John
J
Kjekshus
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D004359:Drug Therapy, Combination; D005260:Female; D006333:Heart Failure / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D012189:Retrospective Studies; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors