c-maf in multiple myeloma: an oncogene enhancing tumor-stroma interactions.
Gene expression profiling studies reported by Hurt et al. in this issue of Cancer Cell reveal an unexpectedly frequent overexpression of c-maf in multiple myeloma and identify molecular targets of c-maf transactivation. The results define c-maf as a prototype of a class of oncogenes that not only stimulate cell cycle progression, but also promote pathological interactions between tumor and stroma cells.
Kienast
Joachim
J
Department of Medicine, Hematology and Oncology, University of Muenster, D-48129 Muenster, Germany. kienast@uni-muenster.de
Berdel
Wolfgang E
WE
D015820:Cadherins / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D056742:Cyclin D2; D016213:Cyclins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D020869:Gene Expression Profiling; D006801:Humans; D039641:Integrin beta Chains / Q000378:metabolism*; D009101:Multiple Myeloma / Q000378:metabolism* / Q000503:physiopathology; D009857:Oncogenes / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051257:Proto-Oncogene Proteins c-maf; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000378:metabolism*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
C080336:CCND2 protein, human; C515300:CCR1 protein, human; D015820:Cadherins; D056742:Cyclin D2; D016213:Cyclins; D004268:DNA-Binding Proteins; D039641:Integrin beta Chains; C495607:MAF protein, human; D011518:Proto-Oncogene Proteins; D051257:Proto-Oncogene Proteins c-maf; D054389:Receptors, CCR1; D019707:Receptors, Chemokine; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C091368:integrin beta7