Knockout mouse points to second form of tryptophan hydroxylase.
A second form of tryptophan hydroxylase (TPH) is expressed in the brain by the gene Tph2. The presence of the gene was discovered when Tph 1(-/-)mice were found to express normal amounts of serotonin in brain, but not in the periphery. Additionally, Tph1(-/-) mice showed no observed behavioral differences from wild-type littermates. Veenstra-Vanderweele and Cook discuss the ramifications of these findings and what they might mean for designing drugs that target the expression and activity of TPH in differing tissues.
Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA.
Jeremy
J
Veenstra-VanderWeele
Edwin H
EH
Cook
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid; D012701:Serotonin / Q000096:biosynthesis; D014365:Tryptophan Hydroxylase / Q000235:genetics* / Q000378:metabolism
D007527:Isoenzymes; D012701:Serotonin; D014365:Tryptophan Hydroxylase