Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer.
OBJECTIVE
To determine the feasibility and toxicity of delivering stereotactic radiosurgery to patients with locally advanced pancreatic cancer.


METHODS
Patients with Eastern Cooperative Oncology Group performance status < or=2 and locally advanced pancreatic cancer were enrolled on this Phase I dose escalation study. Patients received a single fraction of radiosurgery consisting of either 15 Gy, 20 Gy, or 25 Gy to the primary tumor. Acute gastrointestinal toxicity was scored according to the Radiation Therapy Oncology Group criteria. Response to treatment was determined by serial high-resolution computed tomography scanning.


RESULTS
Fifteen patients were treated at 3 dose levels (3 patients received 15 Gy, 5 patients received 20 Gy, and 7 patients received 25 Gy). At these doses, no Grade 3 or higher acute gastrointestinal toxicity was observed. This trial was stopped before any dose-limiting toxicity was reached, because the clinical objective of local control was achieved in all 6 evaluable patients treated at 25 Gy.


CONCLUSIONS
It is feasible to deliver stereotactic radiosurgery to patients with locally advanced pancreatic cancer. The recommended dose to achieve local control without significant acute gastrointestinal toxicity is 25 Gy.
Koong
Albert C
AC
Department of Radiation Oncology, Stanford University, Stanford, California 94305-5152, USA. akoong@stanford.edu
Le
Quynh T
QT
Ho
Anthony
A
Fong
Bryan
B
Fisher
George
G
Cho
Cheryl
C
Ford
Jim
J
Poen
Joseph
J
Gibbs
Iris C
IC
Mehta
Vivek K
VK
Kee
Stephen
S
Trueblood
Ward
W
Yang
George
G
Bastidas
J Augusto
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005240:Feasibility Studies; D006801:Humans; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D016634:Radiosurgery; D011879:Radiotherapy Dosage