Inclusion complexes of 2-chloroethylnitrososulfamides (CENS) with beta-cyclodextrin.
Host-guest association between four CENS (derivated from piperidine, dibenzylamine, dicyclohexylamine and methyl prolinate) and beta-cyclodextrin was carried out in solution and solid state. Characterisation, stoichiometry, solubility, dissociation constants and stability of such complexes were studied, showing that the inclusion with beta-CD appears as a promising mode of formulation of 2-chloroethylnitrososulfamides.
Laboratoire de chimie appliquée, Université de Guelma, BP 401, Guelma 24000, Algeria.
Mekki
M
Kadri
Nabila
N
Dhaoui
Mohamed
M
Abdaoui
Jean-Yves
JY
Winum
Jean-Louis
JL
Montero
D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D046911:Macromolecular Substances; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D015394:Molecular Structure; D009587:Nitrogen Isotopes; D009603:Nitroso Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D000442:Octanols / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins
D000577:Amides; D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D046911:Macromolecular Substances; D009587:Nitrogen Isotopes; D009603:Nitroso Compounds; D000442:Octanols; D013450:Sulfones; D047392:beta-Cyclodextrins; D014867:Water; C031215:betadex