Surveillance of severe invasive group-G streptococcal infections and molecular typing of the isolates in Japan.
The number of patients with severe invasive group-G streptococcal (Streptococcus dysgalactiae subsp. equisimilis) infections has been increasing in Japan. The emm genotypes and SmaI-digested pulsed-field gel electrophoresis DNA profiles were variable among the strains isolated, suggesting there has not been clonal expansion of a specific subpopulation of strains. However, all strains carried scpA, ska, slo and sag genes, some of which may be involved in the pathogenesis of the disease.
Ikebe
T
T
Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
Murayama
S
S
Saitoh
K
K
Yamai
S
S
Suzuki
R
R
Isobe
J
J
Tanaka
D
D
Katsukawa
C
C
Tamaru
A
A
Katayama
A
A
Fujinaga
Y
Y
Hoashi
K
K
Watanabe
H
H
D018829:Adhesins, Bacterial; D000368:Aged; D000369:Aged, 80 and over; D016172:DNA Fingerprinting / Q000379:methods; D004269:DNA, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D010450:Endopeptidases / Q000235:genetics; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction / Q000379:methods; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D012703:Serotyping; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*; D013291:Streptococcus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D018829:Adhesins, Bacterial; D004269:DNA, Bacterial; D010450:Endopeptidases; C053088:C5a peptidase