Perfusion temperature during cardiopulmonary bypass does not affect serum S-100beta release.
BACKGROUND
The potentially harmful effects of normothermia on neurological outcome during cardiopulmonary bypass (CPB) are controversial.


METHODS
In this study, we compared the early and late release patterns of S-100beta, a marker of cerebral injury, after normothermic and moderately hypothermic CPB. Forty-eight patients undergoing coronary artery bypass grafting were randomly assigned to either the normothermia (37 degrees C) or the hypothermia (32 degrees C) group. Serum S-100beta levels were measured until 24 h after CPB. Neurological examination was performed before and after surgery.


RESULTS
With the exception of intraoperative blood glucose levels, there were no differences between groups. This also applied to peak S-100beta values (Gr-N: 3.5 +/- 1.9 microg/l; Gr-H: 3.5 +/- 3.4 microg/l) and values after 24 h (Gr-N: 0.32 +/- 0.16 microg/l; Gr-H: 0.35 +/- 0.28 microg/l).


CONCLUSIONS
The similar pattern of S-100beta release without evident neurological complications in the normothermia group does not suggest an increase in cerebral injury during normothermic CPB.
Dworschak
M
M
Department of Cardiothoracic and Vascular Anesthesia and Intensive Care, General Hospital Vienna, Austria. martin.dworshak@univie.ac.at
Lassnigg
A
A
Tenze
G
G
Zimpfer
D
D
Czerny
M
M
Grimm
M
M
Schmid
R
R
Grubhofer
G
G
D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000378:metabolism / Q000601:surgery; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007036:Hypothermia, Induced; D007527:Isoenzymes / Q000097:blood; D007902:Length of Stay; D008875:Middle Aged; D009414:Nerve Growth Factors; D010477:Perfusion; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000378:metabolism*; D013223:Statistics as Topic; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
D015415:Biomarkers; D001786:Blood Glucose; D006454:Hemoglobins; D007527:Isoenzymes; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form