[On the bile acid receptor FXR].
Farnesoid X receptor (FXR) was identified as a bile acid receptor for regulation of bile acid biosynthesis and cholesterol metabolism. FXR became a potential therapeutic target for lowering serum cholesterol and certain cardiovascular and liver diseases. In this review, the discovery of FXR, its roles in regulating bile acid and cholesterol metabolism and its application in cardiovascular disease will be summarized.
Li
Shuo
S
Department of Physiology, Peking University Health Science Center, Beijing 100083.
Zhang
Zhi-Wen
ZW
Guan
You-Fei
YF
D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D002318:Cardiovascular Diseases / Q000628:therapy; D002784:Cholesterol / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000502:physiology*; D000099150:Receptor, Farnesoid X-Activated
D001647:Bile Acids and Salts; D002784:Cholesterol; D004268:DNA-Binding Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000099150:Receptor, Farnesoid X-Activated