Properties of an alginate gel bead containing a chitosan-drug salt.
A calcium-induced alginate gel bead (Alg-CS) containing chitosan (CS) and 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) was prepared. We then investigated (a) CMP release from Alg-CS, and (b) uptake of bile acid into the Alg-CS, within the gastrointestinal tract. Dried Alg-CS gradually swelled in taurocholate solution, while releasing CMP and taking up bile acid. The amount of bile acid taken up into the Alg-CS increased incrementally according to the degree of deacetylation of CS. Furthermore, the molecular weight of CS also affected the properties of the Alg-CS. An approximately linear relationship was observed between CMP release and bile acid uptake of Alg-CS.
Murata
Yoshifumi
Y
Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa, Japan. y-murata@hokuriku-u.ac.jp
Hirai
Daijirou
D
Kofuji
Kyoko
K
Miyamoto
Etsuko
E
Kawashima
Susumu
S
D000107:Acetylation; D000464:Alginates / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D002850:Chromatography, Gel; D002995:Clofibric Acid / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels; D020723:Glucuronic Acid / Q000737:chemistry*; D006603:Hexuronic Acids / Q000737:chemistry*; D008970:Molecular Weight; D012995:Solubility; D013997:Time Factors; D014867:Water / Q000737:chemistry
D000464:Alginates; D001647:Bile Acids and Salts; D004337:Drug Carriers; D005782:Gels; D006603:Hexuronic Acids; D014867:Water; D002995:Clofibric Acid; D020723:Glucuronic Acid; D048271:Chitosan; D002118:Calcium