Oleanane triterpenoids with inhibitory activity against NFAT transcription factor from Liquidambar formosana.
In a search for inhibitory components from natural products against NFAT transcription factor, this study investigated the ethyl acetate extract of the fruits of Liquidambar formosana. Four oleanane triterpenoids were isolated and identified to be liquidambaric acid, oleanolic acid, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid and lantanolic acid. Of these compounds, 3alpha-acetoxy-25-hydroxy-olean-12-en-28-oic acid (IC50: 4.63 microM) and lantanolic acid (IC50: 12.62 microM) exhibited strong inhibitory activity against the NFAT transcription factor.
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Nguyen Tien
NT
Dat
Im Seon
IS
Lee
Xing Fu
XF
Cai
Guanghai
G
Shen
Young Ho
YH
Kim
D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D019169:Jurkat Cells; D031317:Liquidambar / Q000737:chemistry*; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000037:antagonists & inhibitors*; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
C488647:25-acetoxy-3alpha-hydroxyolean-12-en-28-oic acid; D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D010936:Plant Extracts; D014157:Transcription Factors; D014315:Triterpenes; C494612:lantanolic acid; C413246:oleanane; D009828:Oleanolic Acid