Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer?
A model of immune evasion mediated by tumors expressing constitutively activated Stat3 was recently proposed in Nature Medicine by Wang et al., suggesting opportunities for a new therapeutic approach for cancer.
Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA.
Ana M
AM
Gamero
Howard A
HA
Young
Robert H
RH
Wiltrout
D002455:Cell Division; D018946:Chemokine CCL5 / Q000276:immunology / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000276:immunology / Q000502:physiology; D005802:Genes, MHC Class II / Q000502:physiology*; D016753:Interleukin-10 / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D008958:Models, Molecular; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D019000:Phosphotyrosine; D050796:STAT3 Transcription Factor; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism
D018946:Chemokine CCL5; D004268:DNA-Binding Proteins; D015850:Interleukin-6; D050796:STAT3 Transcription Factor; C439524:TNF protein, human; D015534:Trans-Activators; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D019000:Phosphotyrosine