CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease.
We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.
National Institute of Health and Medical Research (INSERM) Unit 360, Hôpital de la Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. elbaz@chups,jussieu.fr
Alexis
A
Elbaz
Clotilde
C
Levecque
Jacqueline
J
Clavel
Jean-Sébastien
JS
Vidal
Florence
F
Richard
Philippe
P
Amouyel
Annick
A
Alpérovitch
Marie-Christine
MC
Chartier-Harlin
Christophe
C
Tzourio
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D004781:Environmental Exposure; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000706:statistics & numerical data; D010300:Parkinson Disease / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D010575:Pesticides / Q000506:poisoning*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D015995:Prevalence
D010575:Pesticides; D019389:Cytochrome P-450 CYP2D6