T cell cytokines: animal models.
Allergic asthma involves a complex series of reactions within the airways that lead to inflammation and bronchoconstriction. These phenomena are closely linked to the immune response to the allergenic protein mediated by T cells with specificity for the allergen. Antigen presentation by dendritic cells initiates the allergic response, triggering the activation of CD4+ T cells predominantly. These cells secrete Th2 type cytokines, of which IL-4 and IL-5 are best understood, that act on various cells including B cells, eosinophils, macrophages and epithelial cells. These cells mediate, in turn, immunoglobulin E synthesis, and promote an eosinophil rich inflammation through the concerted action of various chemoattractant substances, both lipid-derived and proteins. CD8+ T cells are also activated and may have either anti-inflammatory or pro-inflammatory effects, depending upon the particular experimental model studied. The T cell receptor (TCR) that these cells possess has an important influence on the role they play. TCRalphabeta cells appear more likely to be pro-inflammatory and have antigen specificity whereas TCRgammadelta cells can be either pro- or anti-inflammatory, depending on species and experimental conditions and are not antigen specific. In conclusion, the magnitudes of inflammatory responses and bronchoconstriction following allergen challenge of sensitised animals are T cell driven and are determined, at least in part, by the balance of the T cell subsets that are activated.
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
James G
JG
Martin
Masaru
M
Suzuki
David
D
Ramos-Barbón
Susumu
S
Isogai
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006967:Hypersensitivity / Q000276:immunology; D001239:Inhalation; D008168:Lung / Q000276:immunology; D051379:Mice; D011506:Proteins / Q000276:immunology; D051381:Rats; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines; D011506:Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta