Breast cancer biomarkers and molecular medicine: part II.
In this second part of the two-part review of breast cancer biomarkers and molecular medicine, the first section will consider additional breast cancer prognostic factors, including oncogenes, tumor suppressor genes, cell adhesion molecules, invasion-associated proteins and proteases, hormone receptor proteins, drug resistance proteins, apoptosis regulators, transcription factors, telomerase, DNA repair and methylation and transcriptional profiling using high-density genomic microarrays. The second section will consider the prediction of therapy response using the techniques of pharmacogenetics and pharmacogenomics.
Ross
Jeffrey S
JS
Department of Pathology and Laboratory Medicine, MC 80 Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. rossj@mail.amc.edu
Linette
Gerald P
GP
Stec
James
J
Clark
Edwin
E
Ayers
Mark
M
Leschly
Nick
N
Symmans
W Fraser
WF
Hortobagyi
Gabriel N
GN
Pusztai
Lajos
L
D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D018432:Drug Resistance, Multiple; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D009857:Oncogenes; D010597:Pharmacogenetics; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D019253:Proto-Oncogene Proteins c-bcl-2; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014157:Transcription Factors; D004247:DNA; D019098:Telomerase; D010450:Endopeptidases