Facial variations in sensory responses.
Subjective effects such as stinging, itching and burning commonly occur in the absence of any visible irritation and give rise to discomfort, which may be enough to deter an individual from using even the most effective of skin care products. The purpose of this study was to evaluate the sensitivity of different anatomical regions of the face to determine which region displayed the most intense stinging response to the application of lactic acid. The effect of occlusion on the level of response was also investigated. 45 volunteers were treated with 10% lactic acid on the nasolabial fold, forehead, chin and cheek, occluded and unoccluded for 8 min. Sensory reactions were recorded at 2.5, 5 and 8 min. The response levels on the occluded sites were always significantly lower than on the unoccluded sites, despite the dose per unit area being comparable. Females showed a trend towards being more sensitive to the subjective effects elicited by lactic acid than males, but these results were not conclusive. Interestingly, there was not a complete correlation between individuals who reacted on the nasolabial fold and the other sites, particularly the forehead. A positive stinging response on the nasolabial fold may not necessarily predict subjective responses to a product when used on other areas of the face.
Marriott
Marie
M
Safety and Environmental Assurance Centre, Unilever Colworth Laboratory, Sharnbrook, Bedford, MK44 1LQ, UK.
Whittle
Ed
E
Basketter
David A
DA
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D005148:Facial Dermatoses / Q000209:etiology; D005260:Female; D006801:Humans; D019344:Lactic Acid; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods; D011446:Prospective Studies; D011537:Pruritus / Q000139:chemically induced; D012016:Reference Values; D012494:Sampling Studies; D012677:Sensation / Q000502:physiology; D012680:Sensitivity and Specificity; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology*; D012737:Sex Factors; D012867:Skin / Q000187:drug effects
D019344:Lactic Acid