[Role of the immune response in atherosclerosis and acute coronary syndromes].
Cardiovascular diseases represent one of the most important causes of death in the world. The underlying pathogenetic process is atherosclerosis which leads to the progressive reduction of the arterial lumen and therefore to the ischemia of the perfused organs. Atherogenesis results from the interaction between the biology of the arterial wall and the various stress stimuli present in the circulating blood. The first steps of atherogenesis occur very early, already during the fetal life. Those arterial segments that are subjected to the initiating causes (including hemodynamic stress) show altered endothelial permeability and allow the infiltration of macromolecules, like lipoproteins, in the subintimal space. At the same time, the smooth muscle cells that are subjected to the same local factors produce proteoglycans able to bind lipoproteins and to promote their oxidation. Oxidized lipoproteins induce the expression of chemokines and adhesion molecules on the luminal surface of the endothelium, which then allow the local recruitment of monocytes-macrophages and T lymphocytes. This is a local inflammatory process that, in theory, should contribute to reestablish the homeostasis of the vascular wall by promoting the elimination of injured tissue and its repair. Unfortunately, for unknown reasons, the immuno-inflammatory reaction persists and autoamplifies, the various components of the immune response finally contributing to the pathogenesis of atherosclerosis as well as of atherosclerotic complications.
Inserm EMI 00-16, Faculté de médecine Necker-Enfants Malades, 156, rue de Vaugirard, 75015 Paris, France. caligiuri@necker.fr
Giuseppina
G
Caligiuri
D000789:Angina, Unstable / Q000276:immunology*; D000818:Animals; D001158:Arteries / Q000276:immunology / Q000503:physiopathology; D001323:Autoantibodies / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology; D003324:Coronary Artery Disease / Q000276:immunology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009203:Myocardial Infarction / Q000276:immunology*; D020556:Neutrophil Infiltration / Q000276:immunology; D013601:T-Lymphocytes / Q000502:physiology
D001323:Autoantibodies; D008077:Lipoproteins, LDL