Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
A 69-year-old man was admitted with a large elastic mass in the upper abdomen. Computed tomography revealed a massive tumor in contact with the liver and gastrointestinal endoscopy revealed a gastric adenocarcinoma. He developed acute renal failure with massive proteinuria and died with a marked enlargement of the tumor. Autopsy revealed a tumor located in the lesser omentum. The tumor was considered to be a Gastrointestinal Stromal Tumor (GIST) because it was positive for c-kit. In addition, crescent formations and immune complexes in glomeruli were observed. We report the first case of GIST complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
Nakaya
Izaya
I
Department of Internal Medicine, Kanazawa Municipal Hospital, Kanazawa.
Iwata
Yasunori
Y
Abe
Toshio
T
Yokoyama
Hitoshi
H
Oda
Yoshio
Y
Nomura
Gakuji
G
D058186:Acute Kidney Injury / Q000209:etiology; D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis; D000368:Aged; D018450:Disease Progression; D017809:Fatal Outcome; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications*; D009852:Omentum; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis; D017154:Stromal Cells / Q000473:pathology