Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.
Three new compounds: begonanline (1). nantoamide (2). and methyl (S)-glycerate (3). as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4). dihydrocucurbitacin B (5). cucurbitacin E (6). dihydrocucurbitacin E (7). cucurbitacin I (8). and (-)-auranamide (9). showed cytotoxicity against four human cancer cell lines. 3beta,22alpha-Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.
Wu
Pei-Lin
PL
Department of Chemistry, National Cheng Kung University, Taiwan. wupl@mail.ncku.edu.tw
Lin
Fu-Wen
FW
Wu
Tian-Shung
TS
Kuoh
Chang-Sheng
CS
Lee
Kuo-Hsiung
KH
Lee
Shiow-Ju
SJ
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031112:Begoniaceae / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D018360:Crystallography, X-Ray; D005988:Glyceric Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D001549:Benzamides; D002243:Carbolines; D005988:Glyceric Acids; D014315:Triterpenes; C490046:begonanline; C490048:methyl (S)-glycerate; C490047:nantoamide; C041246:cucurbitacin B; C102326:cucurbitacin E