[Therapeutic drug monitoring of cyclosporine MEPC (Neoral) therapy for interstitial pneumonia].
It is widely recognized that the area under the concentration-time curve (AUC) correlates with the clinical effects of cyclosporine MEPC (Neoral) therapy and adverse reactions to it. In this study, we investigated which single blood-level measurement had correlated best with AUC in interstitial pneumonia therapy. Neoral was prescribed in ten cases of interstitial pneumonia. We measured the concentration during the 4 hours following its administration and calculated AUC0-4 (AUC 0-4 hr). The concentration after 2 hours of administration (C2) correlated best with AUC (r2 = 0.71). This result suggests that C2 monitoring would be a better predictor for AUC than C0 (trough level) monitoring in interstitial pneumonia therapy.
Department of Respiratory Medicine, Tenri Hospital, 200 Mishimacho, Tenri, Nara, 632-8552, Japan.
Tetsuro
T
Inoue
Eisaku
E
Tanaka
Terufumi
T
Kato
Minoru
M
Sakuramoto
Masayoshi
M
Minakuchi
Yuji
Y
Maeda
Ko
K
Maniwa
Kunihiko
K
Terada
Yoshio
Y
Taguchi
D000284:Administration, Oral; D000368:Aged; D016572:Cyclosporine / Q000008:administration & dosage* / Q000097:blood; D016903:Drug Monitoring / Q000379:methods*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000097:blood; D017563:Lung Diseases, Interstitial / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine