Paxdaphnidines A and B, novel penta- and tetracyclic alkaloids from Daphniphyllum paxianum.
Two novel alkaloids, paxdaphnidine A (1) with a unique pentacyclic skeleton and paxdaphnidine B (2) with an uncommon tetracyclic skeleton, were isolated from the stems and leaves of Daphniphyllum paxianum. Their structures were established by spectral methods, especially two-dimensional NMR techniques ((1)H-(1)H COSY, HSQC, HMBC, and NOESY).
State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, PR China.
Zha-Jun
ZJ
Zhan
Sheng-Ping
SP
Yang
Jian-Min
JM
Yue
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D002236:Carbohydrate Conformation; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; C484622:paxdaphnidine A; C484621:paxdaphnidine B