Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA. costa@psych.uic.edu
Erminio
E
Costa
Dennis R
DR
Grayson
Alessandro
A
Guidotti
D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism; D044127:Epigenesis, Genetic; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism; D018682:GABA Agents / Q000378:metabolism; D005786:Gene Expression Regulation; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008715:Methionine / Q000008:administration & dosage; D008959:Models, Neurological; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism; D000091042:Reelin Protein; D012559:Schizophrenia / Q000235:genetics / Q000378:metabolism*; D012697:Serine Endopeptidases; D014635:Valproic Acid / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D018682:GABA Agents; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D008715:Methionine; D012697:Serine Endopeptidases; D005968:Glutamate Decarboxylase