[Neurotoxic effect of 7,8-oxide styrene on striatal neuron culture].
The present study was undertaken to test the hypothesis that the neurotoxic action of styrene may be primarily presynaptic in nature and may involve impaired regulation of DA content and stimulation of DA release. Primary striatal neurons were grown in vitro and exposed to styrene oxide at different concentrations to evaluate the minimal effective dose able to induce these synaptic alterations.
Dipartimento di Medicina interna e Medicina pubblica, Università di Bari.
A
A
D'Aprile
P
P
Corsi
B
B
Nico
G
G
Assennato
D000818:Animals; D002478:Cells, Cultured; D003342:Corpus Striatum / Q000166:cytology*; D004852:Epoxy Compounds / Q000633:toxicity*; D051379:Mice; D009474:Neurons / Q000187:drug effects*
D004852:Epoxy Compounds; C013690:styrene oxide