The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin.
The effect of a synthetic peptide (H92-G110) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p.
Dale
Camila Squarzoni
CS
Laboratory of Pathophysiology, Butantan Institute, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.
Gonçalves
Luis Roberto de Camargo
LR
Juliano
Luiz
L
Juliano
Maria Aparecida
MA
da Silva
Ana Maria Moura
AM
Giorgi
Renata
R
D000818:Animals; D040502:Calgranulin B / Q000737:chemistry* / Q000627:therapeutic use; D003435:Crotalid Venoms; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008666:Metalloendopeptidases; D051379:Mice / Q000378:metabolism*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D000097146:Bothrops jararaca Venom
D040502:Calgranulin B; D003435:Crotalid Venoms; D008666:Metalloendopeptidases; D010975:Platelet Aggregation Inhibitors; D000097146:Bothrops jararaca Venom