Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats.
Compared to saline-challenged rats, rats exposed to 50 microg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 x 10(6) to 2.4 x 10(6)), neutrophils (from 0.09 x 10(6) to 1.8 x 10(6)), the levels of tumor necrosis factor (TNF)-alpha (from 200 pg ml(-1) to 1200 pg ml(-1)), and interleukin (IL)-1beta (from 220 pg ml(-1) to 650 pg ml(-1)) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1beta in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-alpha. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.
College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Beom-Su
BS
Jang
Jong-Chun
JC
Kim
Jae-Sung
JS
Bae
Man-Hee
MH
Rhee
Kwang-Ho
KH
Jang
Jae-Chan
JC
Song
Oh-Deog
OD
Kwon
Seung-Chun
SC
Park
D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology*; D002457:Cell Extracts / Q000627:therapeutic use*; D007375:Interleukin-1 / Q000032:analysis; D007958:Leukocyte Count; D008070:Lipopolysaccharides; D008297:Male; D008518:Medicine, East Asian Traditional; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D011014:Pneumonia / Q000139:chemically induced / Q000175:diagnosis* / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D002457:Cell Extracts; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha