Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis.
Enhanced expression of the human immunodeficiency virus (HIV) co-receptor CXCR4 renders T-lymphocytes more susceptible for infection with HIV. We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes.
Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
Asrat
A
Hailu
Jennie M
JM
Pater
Piet A
PA
Kager
Tom
T
van der Poll
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011336:Probability; D019718:Receptors, CXCR4 / Q000032:analysis*; D015728:Receptors, HIV / Q000032:analysis*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D019562:Viral Load
D015415:Biomarkers; D019718:Receptors, CXCR4; D015728:Receptors, HIV