Malignant gastrointestinal stromal tumor originating in the lesser omentum, complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
A 69-year-old man was admitted with a large elastic mass in the upper abdomen. Computed tomography revealed a massive tumor in contact with the liver and gastrointestinal endoscopy revealed a gastric adenocarcinoma. He developed acute renal failure with massive proteinuria and died with a marked enlargement of the tumor. Autopsy revealed a tumor located in the lesser omentum. The tumor was considered to be a Gastrointestinal Stromal Tumor (GIST) because it was positive for c-kit. In addition, crescent formations and immune complexes in glomeruli were observed. We report the first case of GIST complicated by rapidly progressive glomerulonephritis and gastric carcinoma.
Department of Internal Medicine, Kanazawa Municipal Hospital, Kanazawa.
Izaya
I
Nakaya
Yasunori
Y
Iwata
Toshio
T
Abe
Hitoshi
H
Yokoyama
Yoshio
Y
Oda
Gakuji
G
Nomura
D058186:Acute Kidney Injury / Q000209:etiology; D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis; D000368:Aged; D018450:Disease Progression; D017809:Fatal Outcome; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications*; D009852:Omentum; D010534:Peritoneal Neoplasms / Q000150:complications* / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000175:diagnosis; D017154:Stromal Cells / Q000473:pathology