[Treatment and pathologic change of pachydermoperiostosis].
OBJECTIVE
To investigate the treatment and possible pathogenesis of pachydermoperiostosis.


METHODS
Facelift was performed on five patients with pachydermoperiostosis. Histological studies were performed to check the affected skin for possible pathogenesis.


RESULTS
After the surgery of facelift, appearances of the patients were markedly improved. Histological studies revealed significant changes in the skin, characterized by hyperplasia and thickening of the subcutaneous collagen, as well as an increase of PAS-positive substance.


CONCLUSIONS
Alterations of fibroblast bioactivity might be responsible for the pathogenesis of pachydermoperiostosis. There have been no satisfying treatments to the disease. Facelift is a feasible method to improve the aging appearance of the patients.
Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100041, China.
Jia-jie
JJ
Xu
Sen-kai
SK
Li
Yang-qun
YQ
Li
Qiang
Q
Li
Yong-qian
YQ
Wang
Li-qiang
LQ
Liu
D000328:Adult; D006801:Humans; D008297:Male; D010004:Osteoarthropathy, Primary Hypertrophic / Q000209:etiology / Q000473:pathology / Q000601:surgery*