Lipid profiles in HIV-infected patients receiving combination antiretroviral therapy: are different antiretroviral drugs associated with different lipid profiles?
Levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c), as well as the TC:HDL-c ratio, were compared in patients receiving different antiretroviral therapy regimens. Patients receiving first-line regimens including protease inhibitors (PIs) had higher TC and TG levels and TC : HDL-c ratios than did antiretroviral-naive patients; patients receiving 2 PIs had higher levels of each lipid. Ritonavir-containing regimens were associated with higher TC and TG levels and TC : HDL-c ratios than were indinavir-containing regimens; however, receipt of nelfinavir was associated with reduced risk of lower HDL-c levels, and receipt of saquinavir was associated with lower TC : HDL-c ratios. Patients receiving nonnucleoside reverse-transcriptase inhibitors had higher levels of TC and LDL-c than did antiretroviral-naive patients, although the risk of having lower HDL-c levels was lower than that in patients receiving a single PI. Efavirenz was associated with higher levels of TC and TG than was nevirapine.
Nice Cohort, Infectious Diseases Department, Nice University Hospital, Nice, France.
E
E
Fontas
F
F
van Leth
C A
CA
Sabin
N
N
Friis-Møller
M
M
Rickenbach
A
A
d'Arminio Monforte
O
O
Kirk
M
M
Dupon
L
L
Morfeldt
S
S
Mateu
K
K
Petoumenos
W
W
El-Sadr
S
S
de Wit
J D
JD
Lundgren
C
C
Pradier
P
P
Reiss
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000209:etiology; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D019469:Indinavir / Q000009:adverse effects; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D019438:Ritonavir / Q000009:adverse effects; D019258:Saquinavir / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D019380:Anti-HIV Agents; D008055:Lipids; D014280:Triglycerides; D019469:Indinavir; D002784:Cholesterol; D019258:Saquinavir; D019438:Ritonavir