Neurogenesis: is the adult stem cell young or old?
Stem cell biology is one of the most exciting, controversial, and debated fields in science today. It has been suggested that neuronal replacement therapy using stem cell transplants may be one possible answer to a host of neuropathological disorders including spinal cord injury, stroke, and neurodegenerative diseases. Important sources for stem cells include the developing embryo and adult central nervous system, but will these populations of cells exhibit similar behavior and responses to stimuli? This review will discuss some important similarities and differences between the embryonic and adult stem cell, as well as the basis for developing therapeutic approaches for stem cell replacement.
Ricard
Jerome
J
The Miami Project to Cure Paralysis, Department of Neurosurgery, University of Miami School of Medicine, FL 33136, USA.
Liebl
Daniel J
DJ
D000328:Adult; D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D016922:Cellular Senescence; D002490:Central Nervous System / Q000293:injuries; D006801:Humans; D009474:Neurons / Q000166:cytology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*