[Expression and clinical significance of Fas-FasL of pleomorphic adenoma and adenoid cystic carcinoma in parotid gland].
OBJECTIVE
To determine the expression and clinical significance of Fas and FasL in cases of occurrence and development of pleomorphic adenoma and adenoid cystic carcinoma(ACC) in parotid gland.


METHODS
Using Immunohistochemistry techniques and quantitative analysis under computerized system, we investigated Fas-FasL expression in 21 cases of normal parotid gland, 35 cases of pleomorphic adenoma in parotid gland and 32 cases of ACC in parotid gland.


RESULTS
All cases of ACC of parotid gland showed Fas and FasL negative expression, no correlation was found between the expression of Fas-FasL and the histological type and the pathological grades of ACC. Although both normal parotid gland and pleomorphic adenoma of parotid gland had distinct expression of Fas and FasL, the positive expression of Fas FasL in pleomorphic adenoma of parotid gland cases were both significantly lowered (P<0.01) than that in normal parotid gland.


CONCLUSIONS
Expression of Fas-FasL and Fas FasL mediated cell apoptosis disturbance had significant correlations with the occurrence and malignant development of pleomorphic adenoma and ACC in parotid gland.
Department of Oral and Maxillofacial Surgery, 1st Affiliated Hospital of Kunming Medical College, Kunming 650032, China.
Ming
M
Li
Wei-dong
WD
Tian
Bao-cai
BC
Dong
Qun
Q
Wei
Jin-yun
JY
Li