Prognostic significance of plasma placental growth factor levels in renal cell cancer: an association with clinical characteristics and vascular endothelial growth factor levels.
BACKGROUND
Angiogenesis plays important roles in pathogenesis in human cancer. We assessed the relationship between clinical features of renal cell cancer (RCC) and PlGF levels in relation to VEGF.


METHODS
Plasma PlGF and VEGF levels were measured in patients with renal cell cancer. The levels of these angiogenetic factors were analyzed in relation to clinical parameters.


RESULTS
PlGF and VEGF levels in patients with RCC were significantly higher than those in non-cancer controls. PlGF levels were significantly associated with histological grade and total tumor vascularity (TTV), and VEGF levels were significantly associated with T, M stage, histological grade, venous invasion and TTV. Multivariate analysis showed plasma PlGF was an independent prognostic factor.


CONCLUSIONS
These findings suggested that plasma PlGF levels were significantly associated with the clinical features of RCC, especially prognostic significance.
Department of Urology, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Gunma, Japan.
Kazuhisa
K
Matsumoto
Kazuhiro
K
Suzuki
Hidekazu
H
Koike
Keigo
K
Okamura
Kiyotaka
K
Tsuchiya
Tatsuya
T
Uchida
Yutaka
Y
Takezawa
Mikio
M
Kobayashi
Hidetoshi
H
Yamanaka
D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000098:blood supply / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000098:blood supply / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009389:Neovascularization, Pathologic / Q000378:metabolism; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood*; D011379:Prognosis; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D000072483:Placenta Growth Factor