4. The natural products epothilones A and B as lead structures for anticancer drug discovery: chemistry, biology, and SAR studies.
Altmann
Karl-Heinz
KH
Novartis Institutes for Biomedical Research, Novartis Pharma AG, Corporate Research, CH-4002 Basel, WKL-136.5.22, Switzerland.
Flörsheimer
Andreas
A
O'Reilly
Terence
T
Wartmann
Markus
M
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D034261:Epothilones / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000378:metabolism
D000970:Antineoplastic Agents; D034261:Epothilones; D014404:Tubulin; C093787:epothilone A; C114026:desoxyepothilone B; C093788:epothilone B