Identification of a new HLA-DRB1 allele, HLA-DRB1*0436.
Anovel allele, HLA-DRB1*0436, was identified in a Taiwan indigenous individual by sequence-based typing. DRB1*0436 was identical to DRB1*0403 in exon2 but differed at codons 67-74 with five nucleotide substitutions. This corresponded to three amino acid changes within the P4 peptide-binding pocket of the DR molecule. These substitutions constitute a motif that is also seen in other DRB1*11 alleles. It is possible that the new allele resulted from a gene conversion event.
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
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D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D044466:Asian People; D001483:Base Sequence; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013785:Thailand
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains