The effect of phosphoramidon on inflammation-mediated preterm delivery in a mouse model.
OBJECTIVE
Several metallopeptidases have been implicated in both term and preterm parturition. We hypothesize that endotoxin-induced preterm delivery can be prevented by the administration of a metallopeptidase inhibitor.


METHODS
We used an animal model of endotoxin-induced preterm delivery in timed pregnancy C57Bl/6 mice. Test animals received lipopolysaccharide followed by phosphoramidon, either every 1.5 or every 3 hours. Control mice received lipopolysaccharide followed by buffer injections at the same intervals. The primary outcome was a preterm delivery rate.


RESULTS
The rate of preterm delivery for the control animals was 88.0% compared with the treatment groups of 45.5% for the mice that received phosphoramidon every 3 hours and 30.8% for the group that received it every 1.5 hours (P<.01).


CONCLUSIONS
The administration of a metallopeptidase inhibitor resulted in a decreased rate of preterm delivery in this animal model.
Koscica
Karen L
KL
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
Sylvestre
Georges
G
Reznik
Sandra E
SE
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology / Q000627:therapeutic use*; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D051379:Mice; D008810:Mice, Inbred C57BL; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*
D006020:Glycopeptides; D011480:Protease Inhibitors; D008666:Metalloendopeptidases; C008890:phosphoramidon