Accurate dose calibrator activity measurement of 90Y-ibritumomab tiuxetan.
This investigation examined the accuracy of dose calibrator activity measurement of the beta-emitting radiopharmaceutical (90)Y-ibritumomab tiuxetan.


METHODS
Five different facilities independently measured (90)Y in a 10-mL syringe geometry with 30 dose calibrator models from 3 different manufacturers. The activities ranged from 81.4 MBq (2.2 mCi) to 1,406 MBq (38 mCi) over the volume range of 3-9 mL.


RESULTS
The mean dial settings for (90)Y measurement were 375, 51 x 10, and 897 x 100 for Atomlab, CRC, and Mark V dose calibrators, respectively. The maximum volume dependence was 0.28%/mL.


CONCLUSIONS
This study demonstrated that when measuring all volumes of (90)Y-ibritumomab tiuxetan activity prescriptions, only a single dial setting for a given manufacturer's dose calibrator is required for accurate measurements. Volume corrections are not necessary. For best accuracy, an individually determined dial value should be used.
Siegel
Jeffry A
JA
Nuclear Physics Enterprises, Wellington, Florida 33414, USA. siegelja@aol.com
Zimmerman
Brian E
BE
Kodimer
Kory
K
Dell
Mary A
MA
Simon
William E
WE
D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000627:therapeutic use; D001610:Beta Particles; D002138:Calibration / Q000592:standards*; D019544:Equipment Failure Analysis / Q000379:methods*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy; D015337:Multicenter Studies as Topic; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods / Q000592:standards*; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014481:United States
D000911:Antibodies, Monoclonal; C422802:ibritumomab tiuxetan