Arachnoid cyst with GnRH-dependent sexual precocity and growth hormone deficiency.
The coexistence of gonadotropin-releasing hormone (GnRH)-dependent sexual precocity and growth hormone deficiency in patients with arachnoid cysts is rarely reported, and its pathogenesis is not well recognized. This report describes an 11-year-old female who had a huge intracranial arachnoid cyst with initial symptoms and signs of sexual precocity. Her brain magnetic resonance imaging revealed distorted hypothalamus with a thin and stretched pituitary stalk. After treatment with cysto-peritoneal shunting and gonadotropin-releasing hormone analogue, her puberty was arrested and subnormal growth rate was observed. Catch-up growth was detected after growth hormone therapy. Hence, coexistence of gonadotropin-releasing hormone-dependent sexual precocity and growth hormone deficiency in this patient was confirmed.
Huang
Hsiang-Po
HP
Department of Pediatrics, National Taiwan University Hosital and College of Medicine, Taipei, Taiwan.
Tung
Yi-Ching
YC
Tsai
Wen-Yu
WY
Kuo
Meng-Fai
MF
Peng
Shinn-Forng
SF
D016080:Arachnoid Cysts / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D011629:Puberty, Precocious / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone