Results of laparoscopic gastric bypass in patients with cirrhosis.
BACKGROUND
The safety and efficacy of bariatric surgery in patients with cirrhosis has not been well studied.


METHODS
A retrospective review was conducted of patients with cirrhosis who underwent weight-loss surgery at a single institution.


RESULTS
Out of a total of 2119 patients who underwent laparoscopic Roux-en-Y gastric bypass (RYGBP), 30 patients (1.4%) with cirrhosis were identified. When compared with the entire cohort, patients with cirrhosis were significantly more prone to be heavier (BMI 53 vs 48), older in years (age 50 vs 45), more likely to be male (RR=1.3), and have a higher incidence of diabetes (70% vs 21%) and hypertension (67% vs 21%), P<0.05. The diagnosis of cirrhosis was made intra-operatively in 90% of patients. There were no perioperative deaths, conversions to laparotomy, or liver-related complications. Early complications occurred in 9 patients and included anastomotic leak (1), acute tubular necrosis (4), prolonged intubation (2), ileus (1), and blood transfusion (2). Mean length of hospital stay was 4 days (2-18). There was one late unrelated death and one patient with prolonged nausea and protein malnutrition. The average follow-up time was 16 months (1-48). For patients >12 months postoperatively (n=15), the average percent excess weight loss was 63+/-15%.


CONCLUSIONS
Laparoscopic RYGBP in the cirrhotic patient has an acceptable complication rate and achieves satisfactory early weight loss. Patients tend to be heavier, older, male and more likely to have diabetes and hypertension. Long-term studies are necessary to examine how weight loss impacts established cirrhosis.
The University of Pittsburgh, Department of Surgery, Pittsburgh, PA 15231, USA.
Ramsey M
RM
Dallal
Samer G
SG
Mattar
Jeffrey L
JL
Lord
Andrew R
AR
Watson
Daniel R
DR
Cottam
George M
GM
Eid
Giselle
G
Hamad
Mordecai
M
Rabinovitz
Philip R
PR
Schauer
D000328:Adult; D015992:Body Mass Index; D005234:Fatty Liver / Q000150:complications; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008103:Liver Cirrhosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications* / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome