Fibrin sealants and glues.
Fibrin sealants and fibrin glues have become effective instruments in the care of surgical patients. They have been used as an adjunct to hemostasis, wound healing, tissue adhesion, and drug delivery. In cardiac surgery, fibrin glues have emerged as valuable tools to improve hemostasis, decreased blood transfusions, improve tissue handling, and pretreat vascular grafts. Fibrin glues and sealants are now available commercially in the United States. This article will review the history, pharmacology, uses, and toxicity of fibrin sealants and fibrin glues.
MacGillivray
Thomas E
TE
Cardiac Surgery Unit EDR121, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA. tmacgillivray@partners.org
D000818:Animals; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005557:Formaldehyde / Q000627:therapeutic use; D005780:Gelatin / Q000627:therapeutic use; D005976:Glutaral / Q000627:therapeutic use; D006801:Humans; D012118:Resorcinols / Q000627:therapeutic use
D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D012118:Resorcinols; C083703:gelatin-resorcin-formaldehyde-glutaraldehyde adhesive; D005557:Formaldehyde; D005780:Gelatin; D005976:Glutaral