[The expression of noncollagenous proteins and the tumor differentiation in oral maxillofacial osteosarcoma].
OBJECTIVE
To study the significance of the osteocalcin bone sialoprotein and osteopontin in cell differentiation and matrix mineralization of osteosarcoma.


METHODS
Use immunohistochemistry method to detect the osteocalcin bone sialoprotein and osteopontin expressions in tumor cells and matrix of 50 cases of osteosarcoma.


RESULTS
In tumor cells, the high expression rates of BSP, OPN (30.0%,10.0%, respectively) in fibroblastic osteosarcoma were significantly lower than those of osteoblastic group (75.0%,64.3%, respectively). Other high expression rates of OC, BSP, OPN in or among different groups had no significant difference. In unmineralized neoplastic bone matrix OC, BSP, OPN were weakly expressed. In mineralized neoplastic bone matrix the high positive rates of BSP,OPN (81.4%,76.7% ) were significantly higher than that of OC(4.6% ). But OC was expressed strongly in mature bone.


CONCLUSIONS
In tumor cells of the osteosarcoma expression of OC,BSP,OPN were accompanied by the cell differentiation. It seemed that during the formation and mineralization of neoplatic bone, BSP,OPN,OC had a relatively close relations with mineralization and they showed some extent sequensed expression.
Department of Oral Pathology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
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