[Exposure to PAHs, urinary 1-pyrenol and DNA adducts in samples from a population living at different distances from a steel plant].
This study aims at measuring association between environmental exposure to PAHs and internal or biologically effective dose biomarkers among 212 individuals living at different distance from the industrial area of Taranto, Italy. Environmental PAH exposure was determined by area monitoring. PAH levels was measured by HPLC UV/FL. Urinary 1-hydroxypyrene levels were measured by HPLC/Fluorescence. The levels of DNA adducts were determined by 32P. post-labelling. A questionnaire was administered to gather personal data, residence, occupational history, alcohol, tobacco smoke, and diet, to control for other sources of exposure to PAH. Blood and urinary samples, drawn from the subjects studied were collected and analysed. A multivariate regression model was used to investigate the influence of several confounding factors. Housing was placed within 1 km from smokestacks in Taranto and Statte, whereas they were more far away in Locorotondo and in Alberobello. The prevalence of current smokers was 31.6%.
Ferri
G M
GM
Università degli Studi di Bari, Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro, Policlinico, Bari.
Gallo
A
A
Sumerano
M
M
De Nicoli
M R
MR
Izzotti
A
A
Conversano
M
M
Bailardi
F
F
Antonelli
G
G
Crescenzo
R
R
Ricci
V
V
Cassano
F
F
DeMarinis
G
G
Elia
G
G
Corrado
V
V
Lo Izzo
A
A
De Nichilo
G
G
Ferranini
A
A
Assennato
G
G
D018736:DNA Adducts / Q000032:analysis*; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011721:Pyrenes / Q000032:analysis*; D011795:Surveys and Questionnaires
D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; C033146:1-hydroxypyrene