Predictors of spontaneous bleeding in Dengue.
OBJECTIVE
To identify the predictive factors for spontaneous bleeding manifestations in Dengue illness in infants and children.


METHODS
60 cases of Dengue viral infection with spontaneous skin and or mucosal bleed were compared with 72 cases without spontaneous bleed. The protean bleeding manifestations in dengue infection were recorded. Various clinical and laboratory parameters were analyzed using univariate and logistic regression analysis.


CONCLUSIONS
Prothombin time was abnormal only in cases with spontancous bleed. A combination of (a) biphasic pattern of fever, (b) hemoconcentration, (c) platelet count less than 50,000/mm3 and (d) elevated ALT had a sensitivity of 79.2%, specificity of 64.7% with a positive predictive value of 70% and a negative predictive value of 75% in predicting spontaneous bleeding in dengue.
Shivbalan
So
S
Kanchi Kamakoti Childs Trust Hospital, Nungambakkam, Chennai, India. shivbalan1@rediffmail.com
Anandnathan
K
K
Balasubramanian
S
S
Datta
Manjula
M
Amalraj
Edwin
E
D017677:Age Distribution; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016001:Confidence Intervals; D003715:Dengue / Q000175:diagnosis* / Q000453:epidemiology; D003906:Developing Countries; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000453:epidemiology; D006470:Hemorrhage / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D018570:Risk Assessment; D019595:Severe Dengue / Q000175:diagnosis / Q000453:epidemiology; D012720:Severity of Illness Index; D017678:Sex Distribution; D012871:Skin Diseases / Q000175:diagnosis* / Q000453:epidemiology