Surveillance of severe invasive group-G streptococcal infections and molecular typing of the isolates in Japan.
The number of patients with severe invasive group-G streptococcal (Streptococcus dysgalactiae subsp. equisimilis) infections has been increasing in Japan. The emm genotypes and SmaI-digested pulsed-field gel electrophoresis DNA profiles were variable among the strains isolated, suggesting there has not been clonal expansion of a specific subpopulation of strains. However, all strains carried scpA, ska, slo and sag genes, some of which may be involved in the pathogenesis of the disease.
Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, 162-8640, Japan.
T
T
Ikebe
S
S
Murayama
K
K
Saitoh
S
S
Yamai
R
R
Suzuki
J
J
Isobe
D
D
Tanaka
C
C
Katsukawa
A
A
Tamaru
A
A
Katayama
Y
Y
Fujinaga
K
K
Hoashi
H
H
Watanabe
D018829:Adhesins, Bacterial; D000368:Aged; D000369:Aged, 80 and over; D016172:DNA Fingerprinting / Q000379:methods; D004269:DNA, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D010450:Endopeptidases / Q000235:genetics; D005260:Female; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction / Q000379:methods; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D012703:Serotyping; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*; D013291:Streptococcus / Q000145:classification / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D018829:Adhesins, Bacterial; D004269:DNA, Bacterial; D010450:Endopeptidases; C053088:C5a peptidase