The concept of quasi-tissue-equivalent nanodosimeter based on the glow peak 5a/5 in LiF:Mg,Ti (TLD-100).
We demonstrate the viability of the concept of using existing molecular nanostructures in thermoluminescent solid-state materials as solid-state nanodosimeters. The concept is based on mimicking radiobiology (specifically the ionization density dependence of double strand breaks in DNA) by using the similar ionization density dependence of simultaneous electron-hole capture in spatially correlated trapping and luminescent centres pairs in the thermoluminescence of LiF:Mg,Ti. This simultaneous electron-hole capture has been shown to lead to ionization density dependence in the relative intensity of peak 5a to peak 5 similar to the ratio of double-strand breaks to single-strand breaks for low energy He ions.
Physics Department, Negev Academic College of Engineering, Beer-Sheva, Israel. oster@bgumail.bgu.ac.il
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Horowitz
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Biderman
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Haddad
D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005459:Fluorides; D007477:Ions / Q000032:analysis*; D018499:Linear Energy Transfer; D018020:Lithium Compounds; D008954:Models, Biological; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation / Q000379:methods / Q000639:trends; D016634:Radiosurgery; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013819:Thermoluminescent Dosimetry / Q000295:instrumentation* / Q000379:methods*
D007477:Ions; D018020:Lithium Compounds; C027651:lithium fluoride; D004247:DNA; D005459:Fluorides