[Non-steroidal anti-inflammatory agents for chemoprevention of colorectal polyps: a meta-analysis].
OBJECTIVE
To assess whether or not non-steroidal anti-inflammatory agents (NSAIDs) might prevent colorectal polyps.


METHODS
A systematic review of all relevant randomized controlled trials was performed. We searched all randomized controlled trials of chemoprevention of colorectal polyps. Abstracts was included.


RESULTS
8 trials were assessed in the final systematic analysis. We found a sufficient evidence to support that aspirin might prevent the development of colorectal adenomas in comparing with placebo group in two trails of high quality and large sample (P = 0.003). However, there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis (P > 0.05) and also no evidence to support that dosage of NSAIDs is related with the result of prevention of colorectal adenomas. It was shown that regular aspirin use for 30-60 months cannot reduce the risk of colorectal cancer (P = 0.8). No significant difference in the number of adverse events was found between patients taking NSAIDs and those given placebo (P = 0.9).


CONCLUSIONS
Aspirin might prevent the development of colorectal adenomas, but there is no evidence to support that sulindac and celecoxib might cure or prevent colorectal adenomas or familial adenomatous polyposis and that regular aspirin use might reduce the risk of colorectal cancer.
Department of Gastroenterology, West China Hospital of Sichuan Univesity, Chengdu 610041, China. wyping2002@yahoo.com
Yi-ping
YP
Wang
Qiong
Q
Wang
Tao
T
Gan
Tao
T
Pan
Jin-lin
JL
Yang
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D018890:Chemoprevention; D003111:Colonic Polyps / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D039781:PubMed; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal