Value of tumor M2-PK in thyroid carcinoma: a pilot study.
BACKGROUND
Tumor M2-PK (Tu M2-PK) as the inactive dimeric form of pyruvate kinase M2 has been proven to be elevated in breast, lung, renal and gastrointestinal malignancies. We compared this marker in 26 patients with metastatic thyroid carcinoma using the established tumor marker thyroglobulin (Tg).


METHODS
Plasma Tu M2-PK was measured using an ELISA assay (Schebo Biotech, Giessen, Germany) and Tg was measured in serum using an electrochemiluminescence Immunoassay (Tg Elecsys Systems, Roche, Germany), as a part of the routine follow-up of the patients.


RESULTS
At a cut-off of 15 U/ml, Tu M2-PK was elevated in 50% of the patients; at a cut-off of 20 U/ml (grey zone 15-20 U/ml), Tu M2-PK was elevated in 27% of the patients. The correlation coefficient between serum Tg level and Tu M2-PK was -0.093.


CONCLUSIONS
Tu M2-PK is less valuable for the detection of malignant thyroid disease than Tg.
Klinik fuer Nuklearmedizin, Medizinisches Zentrum fuer Radiologie, Universitaetsklinikum Giessen, Friedrichstrasse 25, 35385 Giessen, Germany. nfbena@nycosoft.com
Nicole Françoise
NF
Bena-Boupda
Semira Sepehr
SS
Rezai
Rigobert
R
Klett
Erich
E
Eigenbrodt
Richard
R
Bauer
D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D010865:Pilot Projects; D011770:Pyruvate Kinase / Q000097:blood*; D013964:Thyroid Neoplasms / Q000201:enzymology* / Q000473:pathology
D014408:Biomarkers, Tumor; D011770:Pyruvate Kinase