Does preoperative administration of metamizol (Novalgin) affect postoperative body weight and duration of recovery from ketamine-xylazine anaesthesia in mice undergoing embryo transfer: a preliminary report.
Thirty-two female mice used for embryo transfer or as controls received either metamizol or equal volumes of normal saline administered subcutaneously following induction of anaesthesia with ketamine-xylazine. Body weight was measured immediately before surgery, after 24 and after 48 h. The duration of the surgical anaesthesia was recorded and postoperative behavioural responses were measured. Comparison of the treatment groups revealed no significant differences in body weight and recovery times, nor were other signs of discomfort detected in either treatment group. It was concluded that administration of metamizol did not provide additional analgesia following embryo transfer in mice anaesthetized with ketamine-xylazine.
Institute for Laboratory Animal Science, Medical School Hanover, Carl-Neuberg Strasse 1, 30625 Hannover, Germany. dorsch.martina@mh-hannover.de
M M
MM
Dorsch
K
K
Otto
H J
HJ
Hedrich
D000758:Anesthesia / Q000662:veterinary*; D000777:Anesthetics / Q000008:administration & dosage*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D004177:Dipyrone / Q000008:administration & dosage*; D004624:Embryo Transfer / Q000662:veterinary*; D005260:Female; D007649:Ketamine / Q000008:administration & dosage; D051379:Mice; D008810:Mice, Inbred C57BL; D011184:Postoperative Period; D011292:Premedication / Q000662:veterinary; D014991:Xylazine / Q000008:administration & dosage
D000777:Anesthetics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014991:Xylazine; D004177:Dipyrone; D007649:Ketamine