Evaluation of a point-of-care coagulation analyzer on patients undergoing cardiopulmonary bypass surgery.
OBJECTIVE
To evaluate a point-of-care (POC) coagulation monitoring analyzer (CoaguChek Pro DM) in patients undergoing cardiopulmonary bypass (CPB).


METHODS
Prospective, blinded study.


METHODS
University hospital.


METHODS
32 patients scheduled for elective cardiac surgery with CPB.


METHODS
Arterial blood samples were drawn four times: preoperatively, postinduction, and 10 minutes and 60 minutes after reversal of heparin with protamine.


RESULTS
Activated partial thromboplastin time (aPTT) and prothrombin time (PT) were measured with a point-of-care system--CoaguChek Pro DM as well as with the Core Laboratory facility using a MD180 analyzer. A total of 128 consecutive paired analyses were conducted. There was very good agreement of the point-of-care-based monitoring of aPTT and PT with the Core Laboratory-based monitoring of aPTT and PT (positive correlations by linear regression analysis: r2 = 0.83 and 0.92, respectively). The turn-around time (time from blood sampling until availability of data for the anesthesiologists) was significantly shorter for the point-of-care system (averaging <10 min) than for the Core Laboratory system (averaging >30 min).


CONCLUSIONS
CoaguChek Pro DM is a reliable and time-efficient point-of-care system for monitoring coagulation of patients undergoing CPB. The use of this system may improve patient care in this group through timely and accurate clinical decisions.
Chavez
Jack J
JJ
Department of Anesthesiology, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA. jchavez@mc.utmck.edu
Weatherall
Jeffrey S
JS
Strevels
Stephen M
SM
Liu
Fengqi
F
Snider
Carolyn C
CC
Carroll
Roger C
RC
D001780:Blood Coagulation Tests / Q000295:instrumentation*; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D019095:Point-of-Care Systems; D011517:Prothrombin Time