A new candidate for insulinomimetic vanadium complex: synergism of oxovanadium(IV)porphyrin and sodium ascorbate.
Vanadyl-meso-tetrakis(1-methylpyridinium-4-yl)porphyrin, VOTMpyP with the VO(N(4)) coordination mode, was found to have a potent insulinomimetic activity on the basis of in vitro and in vivo experiments. When the complex was given simultaneously with sodium ascorbate, the high blood glucose levels of type 1 diabetic model STZ-rats were lowered by synergistic effect, probably sustaining the vanadyl state by means of ascorbate distributed in the organs and tissues of animals. This is the first finding on not only the insulinomimetic vanadyl-porphyrin complex but also the occurrence of a synergistic effect of VOTMpyP and sodium ascorbate to lower the high blood glucose levels in diabetic animals.
Kyoto Pharmaceutical University, Department of Analytical and Bioinorganic Chemistry, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. sukurai@mb.kyoto-phu.ac.jp
Hiromu
H
Sakurai
Toshifumi
T
Inohara
Yusuke
Y
Adachi
Kenji
K
Kawabe
Hiroyuki
H
Yasui
Jitsuya
J
Takada
D000818:Animals; D001205:Ascorbic Acid / Q000493:pharmacokinetics* / Q000627:therapeutic use; D040761:Biomimetic Materials / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D004357:Drug Synergism; D007328:Insulin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051381:Rats; D014638:Vanadates / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014639:Vanadium / Q000493:pharmacokinetics* / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D014639:Vanadium; C075743:oxovanadium IV; D014638:Vanadates; D001205:Ascorbic Acid