[Association between catechol-methyltransferase gene polymorphism and pregnancy induced hypertension].
OBJECTIVE
The Catechol-o-methyltransferase (COMT) gene contains a common functional polymorphism at locus Val158/108Met. This study was to investigate the association between COMT gene polymorphism and pregnancy-induced hypertension (PIH).


METHODS
One hundred and two pregnant women with PIH (PIH group) and 94 normal pregnant women (control group) matched for age and gestation were recruited. Participants were genotyped for COMT at the Val158/108Met locus using PCR-based restriction fragment length polymorphism (RFLP) method.


RESULTS
The frequencies of COMT HH, HL and LL genotypes were 56.9%, 38.2% and 4.9% in PIH group, respectively. These were 47.9%, 43.6% and 8.5% in normal control group, respectively (P > 0.05). The frequencies of the two alleles H and L were 76.0% and 24.0% in PIH group, and 69.7% and 30.3% in control group, respectively (P > 0.05).


CONCLUSIONS
The COMT G1947-->A gene polymorphism is not associated with the generation and the severity of PIH. The mutation genotype does not increase the risk of PIH.
Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun 130041, China.
Bo
B
Sun
Wei-yuan
WY
Zhang
Yan-hui
YH
Zhao
D000328:Adult; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular
D002394:Catechol O-Methyltransferase