[The effect of Herba Erigerontis Compound on epithelial dysplasia of leukoplakia and lichen planus].
OBJECTIVE
To explore the effective Chinese medicine to prevent and treat oral precancerous lesions,and study the clinical therapeutic effect of Erigerontis Compound and its cellular dynamic mechanism.


METHODS
Select 45 volunteers suffering from leukoplakia(LK) and lichen planus(LP)who were divided int treatment and control groups. Treatment group(TG) took Herba Erigrontis Compound capsule for 3 months, Control group(CG) received YUN ZHI Polysacchrodepepitide and vitamin A capsule The results of variation of clinical symptoms, histopathology,and proliferative cell nucleic antigen (PCNA) were observed and compared.


RESULTS
In 79.2% case the degree of epithelia dysplasia was decreased and the TG was less than that of CG; the positive cell counts of PCNA of TG fewer than that of CG obviously;the symptom of TG lessen. All of these of TG were better than that of CG.


CONCLUSIONS
Herba Erigerontis Compound Capsule can prevent and treat LK and LP confirmly. Its anticanceration mechanism is to affect actively the cellular dynamics.
Zhou
Z T
ZT
Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Zhang
S L
SL
Tang
G Y
GY
Jin
Z G
ZG
Zhao
Y F
YF