Depressive symptoms are independently correlated with lipid peroxidation in a female population: comparison with vitamins and carotenoids.
OBJECTIVE
Lipid peroxidation (LPO) is involved in oxidative tissue injuries. The present investigation examined the association between LPO and psychological depressive symptoms.


METHODS
A cross-sectional study was conducted on 66 female volunteers aged 38-70. Lipid peroxides (LOOH) in serum were evaluated by hemoglobin-methylene blue (Hb-MB) method; additionally, serum antioxidants were also detected. To assess depressive symptoms, the Center for Epidemiologic Studies Depression (CES-D) Scale and a subscale in the 28-item General Health Questionnaire (GHQ) were applied.


RESULTS
LOOH concentration displayed a significant positive correlation with CES-D and GHQ depression scores. Multiple regression analysis was performed in which LOOH concentration served as a dependent variable and CES-D scores and antioxidants as independent variables. Consequently, CES-D scores demonstrated significant positive correlation with LOOH.


CONCLUSIONS
The positive relationship between depressive symptoms and LPO in a female population may support the hypothesis that LPO may affect depressive symptoms.
Tsuboi
Hirohito
H
Department of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Nagakute-cho, Aichi 480-1195, Japan. tsuboih@aichi-med-u.ac.jp
Shimoi
Kayoko
K
Kinae
Naohide
N
Oguni
Itaro
I
Hori
Reiko
R
Kobayashi
Fumio
F
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002338:Carotenoids / Q000097:blood*; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008875:Middle Aged; D018384:Oxidative Stress; D014815:Vitamins / Q000097:blood*
D000975:Antioxidants; D014815:Vitamins; D002338:Carotenoids