The Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry: design, development and data assessed.
Many issues plague the pediatric ARF outcome literature, which include data only from single center sources, a relative lack of prospective study, mixture within studies of renal replacement therapy modality without stratification and inconsistent use of methods to control for patient illness severity in outcome analysis. Since January 2001, the Prospective Pediatric CRRT (ppCRRT) Registry Group has been collecting data from multiple United States pediatric centers to obtain demographic data regarding pediatric patients who receive CRRT, assess the effect of different CRRT prescriptions on circuit function and evaluate the impact of clinical variables on patient outcome. The aim of the current paper is to describe the ppCRRT Registry design, review the decision process and rationale for the options chosen for the ppCRRT format and discuss the analysis plan and future projects envisioned for the ppCRRT Registry.
Goldstein
S L
SL
Baylor College of Medicine, Houston, Texas, USA. stuartg@bcm.tmc.edu
Somers
M J G
MJ
Brophy
P D
PD
Bunchman
T E
TE
Baum
M
M
Blowey
D
D
Mahan
J D
JD
Flores
F X
FX
Fortenberry
J D
JD
Chua
A
A
Alexander
S R
SR
Hackbarth
R
R
Symons
J M
JM
D058186:Acute Kidney Injury / Q000150:complications / Q000401:mortality / Q000628:therapy; D002648:Child; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology; D011446:Prospective Studies; D012042:Registries; D017582:Renal Replacement Therapy / Q000379:methods*; D012107:Research Design; D012307:Risk Factors; D012720:Severity of Illness Index; D014481:United States