Gas chromatography/mass spectrometric identification of dopaminergic metabolites in striata of rats treated with L-DOPA.
The ex vivo identification of dopaminergic metabolites present in rat striata after (L-DOPA + benserazide) treatment is reported. The different metabolites have been identified as the trimethylsilyl derivatives in the striatal extracts by gas chromatography/mass spectrometry.
Spectrométrie de masse Bio-Organique, UMR 6014 CNRS, Université de Rouen, 76821 Mont-saint-Aignan cedex, France. Corinne.Loutelier@univ-rouen.fr
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Loutelier-Bourhis
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Legros
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Bonnet
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Costentin
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Lange
D000818:Animals; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001545:Benserazide / Q000008:administration & dosage / Q000493:pharmacokinetics; D003342:Corpus Striatum / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D015259:Dopamine Agents / Q000032:analysis*; D004359:Drug Therapy, Combination; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D007274:Injections, Intraperitoneal; D007980:Levodopa / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000978:Antiparkinson Agents; D015259:Dopamine Agents; D007980:Levodopa; D001545:Benserazide