[New therapeutic strategies for the different subtypes of urticaria].
Urticaria is one of the most common skin diseases. It is divided into several categories including acute and chronic urticaria as well as physical urticaria and special subtypes such as cholinergic and autoimmune urticaria. The causes of urticaria are multiple. In more than 80%, urticaria is triggered by an inflammatory focus, a subclinical infection or autoimmune actions. In addition, non-specific pharmacological or toxin-mediated release of inflammatory mediators from basophils or mast cells can also trigger urticaria. These new aspects in the pathophysiology of urticaria suggest new and promising therapeutic strategies. The first line treatment of urticaria still consists of non-sedating H1-antihistamines. Since urticaria has a profound impact on quality of life, effective treatment is very important. We consider new therapeutic options based on our long-term experience in treating patients with urticaria.
Raap
U
U
Klinik und Poliklinik für Dermatologie und Venerologie, Medizinische Hochschule Hannover, Hannover. mail@ulrike-raap.de
Liekenbröcker
T
T
Wieczorek
D
D
Kapp
A
A
Wedi
B
B
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D015551:Autoimmunity / Q000276:immunology; D002738:Chloroquine / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D003080:Cold Temperature / Q000009:adverse effects; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy; D016480:Helicobacter pylori; D006633:Histamine Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D011312:Pressure / Q000009:adverse effects; D013290:Streptococcal Infections / Q000150:complications / Q000188:drug therapy; D013997:Time Factors; D014581:Urticaria / Q000145:classification / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; D010406:Penicillins; D002738:Chloroquine; D003622:Dapsone