Minibioreactors.
The performance of currently available minibioreactors with volumes below about 100 ml is reviewed. Bioreactors are characterized by their area of application, by mass transfer and mixing characteristics and by their suitability for on-line monitoring and control. The review comprises shaken bioreactors such as shake-flasks, microtiter plates and test-tubes, stirred bioreactors including spinner-flasks for the cultivation of mammalian cells and various special reactors particularly involving on-line monitoring as e.g. membrane inlet mass spectrometry and NMR.
Biochemical Engineering Institute, Saarland University, 66123 Saarbruecken, Germany.
Sathish
S
Kumar
Christoph
C
Wittmann
Elmar
E
Heinzle
D000818:Animals; D019149:Bioreactors / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D006801:Humans; D008904:Miniaturization / Q000379:methods*