Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women.
Loss of imprinting (LOI) of insulin-like growth factor-II (IGF-II) may be an inherited epigenetic trait that is polymorphic in the population, and its presence may predispose an individual to the development of colorectal cancer. We evaluated the association between LOI of IGF-II in normal colonic mucosal samples and adenomas in women participating in a colonoscopy screening study. Among 40 participants, 11 (27.5%) had LOI of IGF-II in their normal colonic mucosal tissue. After adjusting for body mass index and family history of colorectal cancer, LOI status was associated with a fivefold increased risk of adenoma formation (odds ratio = 5.2, 95% confidence interval = 1.0 to 26.7). On average, IGF-II expression was more than threefold higher among women with LOI of IGF-II than among women with normal imprinting status. Our findings support the hypothesis that LOI of IGF-II is an epigenetic trait polymorphic in the population and suggest that LOI of IGF-II may play a role in colorectal cancer. These findings are intriguing and need to be confirmed in larger studies.
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. kw114v@nih.gov
Karen
K
Woodson
Andrew
A
Flood
Lisa
L
Green
Joseph A
JA
Tangrea
Jeffrey
J
Hanson
Brooks
B
Cash
Arthur
A
Schatzkin
Phillip
P
Schoenfeld
D000199:Actins / Q000378:metabolism; D000236:Adenoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D003106:Colon; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000235:genetics*; D019175:DNA Methylation; D018076:DNA, Complementary / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018392:Genomic Imprinting; D006801:Humans; D015994:Incidence; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment; D015854:Up-Regulation
D000199:Actins; D018076:DNA, Complementary; D007335:Insulin-Like Growth Factor II