Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study).
In a nonrandomized feasibility study of therapeutic hypothermia in acute myocardial infarction, 18 patients were treated with endovascular cooling (Alsius, Irvine, California) as adjunctive therapy to primary percutaneous coronary intervention to assess measures of infarct size (area under the curve creatinine kinase-MB and technetium-99m single-photon emission computed tomography sestamibi) and the quality of myocardial perfusion (continuous ST-segment monitoring). Periprocedural endovascular cooling successfully decreased core body temperature (median 33.5 degrees C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury.
Duke Clinical Research Institute, Durham, North Carolina 27715, USA. kandz002@mc.duke.edu
David E
DE
Kandzari
Alan
A
Chu
Bruce R
BR
Brodie
Thomas A
TA
Stuckey
James B
JB
Hermiller
George W
GW
Vetrovec
Karen L
KL
Hannan
Mitchell W
MW
Krucoff
Robert H
RH
Christenson
Raymond J
RJ
Gibbons
Kristina N
KN
Sigmon
Jyostna
J
Garg
Victor
V
Hasselblad
Kenneth
K
Collins
Robert A
RA
Harrington
Peter B
PB
Berger
Nicholas A
NA
Chronos
Judith S
JS
Hochman
Robert M
RM
Califf
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D003131:Combined Modality Therapy; D003402:Creatine Kinase / Q000378:metabolism; D052279:Creatine Kinase, MB Form; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000379:methods*; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000378:metabolism / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000000981:diagnostic imaging / Q000378:metabolism / Q000517:prevention & control*; D010865:Pilot Projects; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
D007527:Isoenzymes; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form