[Substance P in the sputum of patients with chronic obstructive pulmonary disease and occupational exposure to respiratory irritants].
The role of tachykininis in airway inflammation has been extensively demonstrated in experimental animal models, but evidence in humans is very sparse. The aim of this study was first to quantify the content of substance P (SP) in sputum of a group of patients, with chronic obstructive pulmonary disease and with exposure to occupational irritants. Secondly, to compare them with sputum SP content of a group of control subjects.
Boschetto
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P
Sezione di Igiene e Medicina del Lavoro, Università degli Studi di Ferrara.
Quintavalle
S
S
Mazzetti
L
L
Miotto
D
D
Bononi
I
I
Mapp
C E
CE
De Rosa
E
E
D006801:Humans; D007509:Irritants / Q000633:toxicity*; D016273:Occupational Exposure / Q000009:adverse effects*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism*; D013183:Sputum / Q000737:chemistry*; D013373:Substance P / Q000032:analysis*
D007509:Irritants; D013373:Substance P