Diltiazem-induced photodistributed hyperpigmentation.
Diltiazem is a calcium-channel antagonist commonly prescribed in the treatment of cardiovascular disease. Although an extensive spectrum of cutaneous reactions to diltiazem has been described, only two published reports of hyperpigmentation induced by diltiazem are known. We report the cases of a 71-year-old black male and a 49-year-old Hispanic male, who both presented with characteristic hyperpigmentation on sun-exposed areas after taking an extended-release form of diltiazem hydrochloride (Tiazac).
Boyer
Molly
M
Department of Dermatology, Baylor College of Medicine, Houston.
Katta
Rajani
R
Markus
Ramsey
R
D000368:Aged; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D004110:Diltiazem / Q000009:adverse effects* / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000139:chemically induced; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced*
D002121:Calcium Channel Blockers; D004110:Diltiazem