The potential of phosphodiesterase 4 inhibitors for the treatment of depression: opportunities and challenges.
The potential use of phosphodiesterase 4 (PDE4) inhibitors to treat various inflammatory diseases such as asthma and chronic obstructive pulmonary disease has garnered significant attention from the pharmaceutical industry over the last few years. In contrast, the potential use of PDE4 inhibitors to treat central nervous system disorders, such as major depressive disorders, has received less attention. With a growing body of work linking intracellular signaling pathways such as modulation of the cAMP second messenger system to a positive outcome following antidepressant therapy, the role that PDE4 inhibitors could play in the treatment of mood disorders has become more apparent. The following review examines the promise that PDE4 inhibitors may hold for the treatment of these diseases.
Renau
Thomas E
TE
Roche Palo Alto, 3431 Hillview Ave, Palo Alto, CA 94304, USA. thomas.renau@roche.com
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000139:chemically induced
D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D010726:Phosphodiesterase Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4