Hepatitis C virus isolates from Argentina disclose a novel genotype 1-associated restriction pattern.
Hepatitis C virus isolates which disclosed a novel genotype 1-associated restriction pattern by restriction fragment length polymorphism analysis were characterized. Except for a mother and child pair, the patients were unrelated. Sequence analysis showed a G-->A substitution leading to a new RsaI recognition site. Phylogenetic analysis revealed that these isolates constitute a novel genetic lineage within the main cluster of genotype 1 strains.
Gismondi
María Inés
MI
Laboratorio de Virología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Ciudad de Buenos Aires, Argentina. migismondi@yahoo.com.ar
Staendner
Lothar Heinrich
LH
Grinstein
Saúl
S
Guzmán
Carlos Alberto
CA
Preciado
María Victoria
MV
D020121:5' Untranslated Regions / Q000737:chemistry / Q000235:genetics*; D001118:Argentina; D001483:Base Sequence; D005843:Geography; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006526:Hepatitis C / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D020121:5' Untranslated Regions