Total synthesis of the novel NF-kappaB inhibitor (-)-cycloepoxydon.
An enantioselective total synthesis of the novel, biologically active epoxyquinone natural product (-)-cycloepoxydon has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. A new cycloepoxydon related heptacyclic dimer has been prepared and characterized. [reaction: see text]
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India. gm@orgchem.iisc.ernet.in
Goverdhan
G
Mehta
Kabirul
K
Islam
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism; D045744:Cell Line, Tumor; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D016328:NF-kappa B; C113318:cycloepoxydon