Maternal diclofenac sodium ingestion and severe neonatal pulmonary hypertension.
We describe a case of severe pulmonary hypertension and transient right-sided hypertrophic cardiomyopathy in a neonate, caused by premature closure of ductus arteriosus after short-term maternal use of diclofenac sodium (Voltaren). In view of this associated complication, diclofenac sodium should be avoided during pregnancy. In addition, maternal diclofenac sodium ingestion should be suspected if a newborn develops severe pulmonary hypertension and/or right-sided hypertrophic cardiomyoptathy with closed ductus arteriosus.
Department of Paediatrics, Queen Elizabeth Hospital, Kowloon, Hong Kong, China. kiuloksiu@netscape.net
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Siu
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Lee
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology*; D007231:Infant, Newborn; D007251:Influenza, Human / Q000188:drug therapy; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac