Heat shock proteins in mammalian development.
Mammalian development follows a defined but adjustable program, depending on the plasticity of embryonic cells 'response to environmental changes. Heat shock proteins (Hsp) are integral part of this developmental program and gene targeting experiments have started to unravel developmental processes, which exhibit specific requirements for Hsps (e.g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development.
Christians
Elisabeth S
ES
Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. ec1402@yahoo.com
Zhou
Qi
Q
Renard
JeanPaul
J
Benjamin
Ivor J
IJ
D000818:Animals; D005314:Embryonic and Fetal Development; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D013091:Spermatogenesis / Q000502:physiology*
D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins