[Role of the adaptins, dynamin like GTP-ases and Rab proteins in metabolic disorders and various infections].
Numerous metabolic and genetic diseases are due to mutations in adaptins, dynamin-like GTP-ases or disorders in trafficking machinery mediated by Rab proteins. A great number of pathogenes including viruses (HIV, SIV), bacteria and protozoa use various elements of endocytic/trafficking machinery to get into the host cells and to make their infection successful. Their different strategies are discussed.
Zakład Biologii Komórki, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN w Warszawie.
Marcin
M
Kierczak
Liliana
L
Surmacz
Jolanta
J
Wiejak
Elzbieta
E
Wyroba
D000818:Animals; D034281:Dynamins / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D008659:Metabolic Diseases / Q000378:metabolism*; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D026901:Membrane Transport Proteins; D020691:rab GTP-Binding Proteins; D034281:Dynamins