Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana.
Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been described for this species. These compounds were tested for their antiproliferative effects on tumor cell lines using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl- 2H-tetrazolium bromide (MTT) assay and on sea urchin egg development, as well as for their lytic properties on mouse erythrocytes. All diterpenes reduced the viability of tumor cells and inhibited sea urchin egg cleavage. None of the tested compounds presented hemolytic activity.
Costa-Lotufo
Letícia Veras
LV
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Silveira
Edilberto Rocha
ER
Barros
Maria Claudia
MC
Lima
Mary Anne
MA
De Moraes
Maria Elisabete
ME
De Moraes
Manoel Odorico
MO
Pessoa
Cláudia
C
D045784:Abietanes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D010063:Ovum / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012617:Sea Urchins; D029648:Verbenaceae
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts