Catastrophic kinesins: piecing together their mechanism by 3D reconstruction.
Kin Is, kinesins with an internal catalytic domain, de-polymerize microtubules from both ends, and the KIF2C crystal structure presented by ([this issue of Cell]) provides provocative evidence to support the theory that the highly conserved sequences are critical structural elements in these catastrophic kinesins.
Ems-McClung
Stephanie C
SC
Medical Sciences Program, Indiana University, 915 E. 3rd Street, Bloomington, IN 47405, USA.
Walczak
Claire E
CE
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D020134:Catalytic Domain; D016547:Kinesins / Q000737:chemistry*; D051379:Mice; D008870:Microtubules / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
D000255:Adenosine Triphosphate; D016547:Kinesins