Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata.
A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one ( 1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.
Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin-gu, Seoul, Korea.
Joong Sup
JS
Shim
Jin Hee
JH
Kim
Jiyong
J
Lee
Si Na
SN
Kim
Ho Jeong
HJ
Kwon
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects; D016222:Fibroblast Growth Factor 2 / Q000187:drug effects*; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018919:Neovascularization, Physiologic / Q000187:drug effects; D029595:Orchidaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D007529:Isoflavones; D010936:Plant Extracts; D016222:Fibroblast Growth Factor 2