[Genetic polymorphism of biotransforming enzymes and genotoxic effects of styrenes].
A cross-sectional study was carried out on laminators producing glass-fibre reinforced plastics, to evaluate the role of genetic polymorphism of xenobiotic metabolising enzymes on the genotoxicity of styrene. Clastogenic effects, evaluated by the micronucleus test, are related with end-of-shift urinary concentration of 4-vinylphenol and seem to be modulated by NQO1 polymorphism; aneuploidogenic effects, evaluated by the identification of centromers in micronuclei using the fluorescence in situ hybridisation technique with a pancentromeric probe, are related with before-shift urinary levels of mandelic and phenylglyoxylic acids and seem to be modulated by the GSTM1 polymorphism.
Laboratorio di Tossicologia Industriale, Centro Studi e Ricerche ISPESL presso l'Università di Parma.
G
G
De Palma
P
P
Mozzoni
E
E
Scotti
P
P
Manini
R
R
Andreoli
A
A
Naccarati
F
F
Mercati
L
L
Migliore
A
A
Mutti
D000328:Adult; D001711:Biotransformation; D003430:Cross-Sectional Studies; D004798:Enzymes / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D020058:Styrene / Q000493:pharmacokinetics* / Q000633:toxicity
D004798:Enzymes; D020058:Styrene