Cerebrospinal fluid analysis for Whipple's disease in patients with progressive supranuclear palsy.
The clinical picture of neurological involvement in Whipple's disease (WD) may resemble progressive supranuclear palsy (PSP). We looked for WD pathogen DNA in the cerebrospinal fluid of 9 patients with a clinical diagnosis of PSP. The analysis was negative for all samples, showing that WD is not commonly involved in the aetiopathogenesis of PSP.
Pezzella
Francesca Romana
FR
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome, Italy.
Paglia
Maria Grazia
MG
Colosimo
Carlo
C
D000368:Aged; D001921:Brain / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid*; D004269:DNA, Bacterial / Q000134:cerebrospinal fluid*; D003937:Diagnosis, Differential; D005260:Female; D006094:Gram-Positive Bacteria / Q000235:genetics*; D016908:Gram-Positive Bacterial Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D016133:Polymerase Chain Reaction; D013494:Supranuclear Palsy, Progressive / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008061:Whipple Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*
D002556:Cerebrospinal Fluid Proteins; D004269:DNA, Bacterial