HIV infection: point-of-care testing.
OBJECTIVE
To review the data regarding point-of-care testing for the diagnosis of HIV infection in the US.


METHODS
English-language literature was identified via MEDLINE (1980-August 2003) using key words such as rapid HIV tests and HIV antibody testing. Textbooks and other pertinent resources were also reviewed.


METHODS
All articles identified through the data sources above were evaluated and reviewed if pertinent to the objective.


RESULTS
The Centers for Disease Control and Prevention (CDC) has announced an effort to expand currently recommended strategies to prevent new infections with HIV. The cornerstone of this initiative is the availability of the new rapid test for antibodies to HIV (OraQuick Rapid HIV-1 Antibody Test, OraSure Technologies, Bethlehem, PA). The effectiveness, sensitivity, and specificity of this test have been evaluated in a number of cross-sectional studies using previously or simultaneously performed HIV enzyme immunoassays with Western blot confirmation as a reference standard. Although there are several limitations to consider, results of these studies suggest that this test has comparable ability to detect HIV antibodies to other commercially available tests.


CONCLUSIONS
The OraQuick test is simple enough to be performed in many settings including those that facilitate achievement of the goals outlined by the CDC. Availability of this test should have a dramatic impact on HIV detection and prevention strategies.
Donovan
Brian J
BJ
Infectious Diseases, Bristol-Myers Squibb Company, Princeton, NJ 08543-4500, USA. brian.donovan@bms.com
Rublein
John C
JC
Leone
Peter A
PA
Pilcher
Christopher D
CD
D015492:AIDS Serodiagnosis / Q000295:instrumentation*; D003955:Diagnostic Tests, Routine; D015483:HIV Antibodies / Q000097:blood; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D019095:Point-of-Care Systems; D012680:Sensitivity and Specificity; D014481:United States / Q000453:epidemiology
D015483:HIV Antibodies