Catastrophic kinesins: piecing together their mechanism by 3D reconstruction.
Kin Is, kinesins with an internal catalytic domain, de-polymerize microtubules from both ends, and the KIF2C crystal structure presented by ([this issue of Cell]) provides provocative evidence to support the theory that the highly conserved sequences are critical structural elements in these catastrophic kinesins.
Medical Sciences Program, Indiana University, 915 E. 3rd Street, Bloomington, IN 47405, USA.
Stephanie C
SC
Ems-McClung
Claire E
CE
Walczak
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D020134:Catalytic Domain; D016547:Kinesins / Q000737:chemistry*; D051379:Mice; D008870:Microtubules / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary
D000255:Adenosine Triphosphate; D016547:Kinesins