Cognitive and motor functioning in a patient with selective infarction of the left basal ganglia: evidence for decreased non-routine response selection and performance.
Focal damage to the basal ganglia is relatively rare, and little is known about the cognitive effects of damage to specific basal ganglia structures. A 28-year-old, highly educated male (patient RI) sustained a unilateral left ischemic infarction involving primarily the putamen and secondarily the head of the caudate and the anterior internal capsule. Two detailed neuropsychological assessments, at 3 and 16 months post-infarction, revealed that a majority of cognitive abilities were spared. RI's general intelligence, simple attention, concept formation, cognitive flexibility, and explicit memory were unaffected. Select cognitive abilities were affected, and these appeared to be related to direct involvement of the putamen and/or to indirect disruption of circuits between the basal ganglia and frontal lobes. Consistent with involvement of the left putamen, RI showed micrographia with his right hand. Interestingly, his micrographia was context-dependent, appearing only when verbal expression was involved (e.g., present when writing spontaneously, but not when copying sentences or when drawing). Evidence of disruption to frontal systems included variably decreased sustained attention, mildly decreased ability to generate words and to generate ideas, and significantly impaired abstraction ability in both verbal and visual modalities. Although there are several possible interpretations for these findings, this pattern of cognitive and motor functioning is consistent with neuroimaging research suggesting that the frontal/subcortical circuit between the putamen and frontal motor areas plays a role in non-routine response selection and performance.
Psychology Department, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont., Canada M6A 2E1. atroyer@baycrest.org
Angela K
AK
Troyer
Sandra E
SE
Black
Maria L
ML
Armilio
Morris
M
Moscovitch
D000328:Adult; D000339:Affect / Q000502:physiology; D001288:Attention / Q000502:physiology; D001480:Basal Ganglia Diseases / Q000209:etiology*; D020520:Brain Infarction / Q000150:complications*; D003071:Cognition / Q000502:physiology*; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D005793:Generalization, Psychological / Q000502:physiology; D006801:Humans; D007360:Intelligence / Q000502:physiology; D007361:Intelligence Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D009483:Neuropsychological Tests; D014705:Verbal Behavior / Q000502:physiology