Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine.
The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.
Central Research Laboratory, Dong-Wha Pharm. Ind. Co. Ltd, Anyang, Kyunggi 430-017, South Korea. org301@iris.dwcrc.co.kr
Dong Rack
DR
Choi
Jung Han
JH
Shin
Jin
J
Yang
Sue Hye
SH
Yoon
Yong Ho
YH
Jung
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D024841:Fluoroquinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011759:Pyrrolidines