Nutritional markers following duodenal switch for morbid obesity.
BACKGROUND
Laparoscopic duodenal switch with gastric reduction (LapDS) is a minimally invasive hybrid operation combining moderate intake restriction with moderate malabsorption for treatment of morbid obesity. In LapDS, both the quantity of food ingested and the efficiency of digestion are reduced.


METHODS
A cohort of 589 sequential LapDS patients had laboratory studies drawn annually. Serum markers for calcium, iron and protein metabolism and for hepatic function were analyzed using SAS statistical software.


RESULTS
There were 95 men and 494 women. Mean age was 44 years, mean BMI 50 kg/m(2) and mean preoperative weight 142 kg. Although mean hemoglobin decreased below reference and mean parathyroid hormone (PTH) increased above reference, similar to abnormal values reported after Roux-en-y gastric bypass, both hemoglobin and calcium in LapDS readily returned to within the reference range following supplementation with iron and calcium respectively. Mean iron, corrected calcium, alkaline phosphatase, albumin, total protein, aspartate aminotransferase (AST), alanine transaminase (ALT), and bilirubin remained within the normal range.


CONCLUSIONS
LapDS is not associated with broad nutritional deficiencies. Annual laboratory studies, which are required following any type of bariatric operation, appear to be sufficient to identify unfavorable trends. In selected patients, additional iron and calcium supplementation are effective when indicated.
Rabkin
Robert A
RA
Pacific Laparoscopy, San Francisco, CA, USA. rrabkin@pacificsurgery.com
Rabkin
John M
JM
Metcalf
Barbara
B
Lazo
Myra
M
Rossi
Michael
M
Lehman-Becker
Lee B
LB
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D015992:Body Mass Index; D002118:Calcium / Q000378:metabolism*; D005260:Female; D015390:Gastric Bypass / Q000009:adverse effects / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D010535:Laparoscopy; D008111:Liver Function Tests; D008286:Malabsorption Syndromes / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery; D011506:Proteins / Q000378:metabolism*
D015415:Biomarkers; D006454:Hemoglobins; D011506:Proteins; D007501:Iron; D002118:Calcium