Cavum septum pellucidum and its increased prevalence in schizophrenia: a neuroembryological classification.
Thirty-two female (mean age=52.9 years [SD=9.2]) patients with a diagnosis of residual schizophrenia and 19 female (mean age=51.1 years [SD=12.7]) control subjects were studied through cerebral Magnetic Resonance Imaging. Along the entire surface of the septum pellucidum, 1-mm coronal slices were performed in all subjects. The authors classified the cavum septum pellucidum into three types based on embryological development. The prevalence of a cavum was significantly higher in the patients with schizophrenia (Chi square 6.112. p < 0.05). No other significant associations with previously described morphological brain changes were found. Although this result was found in previous reports (DeGreef et al., 1992; DeLisi et al., 1993), our discussion focused on the neurodevelopmental theory of the septum pellucidum and its possible association with schizophrenia.
Department of Anatomy, School of Medicine, University of Salvador, Buenos Aires, Argentina. galarzamarcelo@hotmail.com
Marcelo
M
Galarza
Alicia B
AB
Merlo
Adriana
A
Ingratta
Eduardo F
EF
Albanese
Alfonso M
AM
Albanese
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000453:epidemiology* / Q000473:pathology; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000196:embryology; D013997:Time Factors