Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione.
The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the gamma-Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms.
Cacciatore
Ivana
I
Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, 66013 Chieti, Italy.
Di Stefano
Antonio
A
Luisi
Grazia
G
Pinnen
Francesco
F
Sozio
Piera
P
D005978:Glutathione / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*
D010455:Peptides; D005978:Glutathione