The development of hepatocellular carcinoma among prospectively followed children with chronic hepatitis B virus infection.
We prospectively followed 426 children with chronic hepatitis B virus infection. During 6250 person-years, 2 boys developed hepatocellular carcinoma, with an incidence of 32 per 100,000 person-years. Both had e antigen seroconversion in early childhood and cirrhosis. Early e antigen seroconversion and/or cirrhosis may be risk factors for hepatocellular carcinoma.
Wen
Wan-Hsin
WH
Department of Pediatrics, National Taiwan University Hospital, and the Department of Pediatrics, Cardinal Tien Hospital, Taipei, Taiwan. mhchang@ha.mc.ntu.edu.tw
Chang
Mei-Hwei
MH
Hsu
Hong-Yuan
HY
Ni
Yen-Hsuan
YH
Chen
Huey-Ling
HL
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006513:Hepatitis B e Antigens / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications*; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000453:epidemiology*; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors
D006513:Hepatitis B e Antigens; D000410:Alanine Transaminase