Design and synthesis of a novel family of semi-rigid ligands: versatile compounds for the preparation of 99mTc radiopharmaceuticals.
Synthetic pathways to a range of novel semi-rigid tetradentate ligands, with sulfur, amido or amino donor groups, designed to coordinate technetium 99m have been developed. The technetium-99m complexes have been prepared and their stabilities in serum and by metathesis reaction via cysteine exchange reactions were compared. HPLC comparison of two (99m)Tc-complexes and their rhenium analogues led to the first proof of the nature of our radioactive complexes.
Le Gal
Julien
J
Laboratoire de Chimie Inorganique, EA 807, Université Paul Sabatier, Bat. IIR1, 118, route de Narbonne, 31062 Toulouse, France.
Latapie
Laure
L
Gressier
Marie
M
Coulais
Yvon
Y
Dartiguenave
Michèle
M
Benoist
Eric
E