False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam.
At the bone marrow transplantation center of the San Martino Hospital (Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% (38 of 386 patients) in the period from January 1999 through January 2003 to 36% (21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P<.001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT ( chi 2=34.7; P<.001) and underlying disease ( chi 2=21.14; P<.001) to be associated with PA positivity. Of 15 PT batches tested, 12 had positive PA test results.
Infectious Disease Unit, National Institute for Cancer Research and University of Genoa, Genoa, Italy. viscolic@unige.it
Claudio
C
Viscoli
Marco
M
Machetti
Paola
P
Cappellano
Barbara
B
Bucci
Paolo
P
Bruzzi
Maria Teresa
MT
Van Lint
Andrea
A
Bacigalupo
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000946:Antigens, Fungal / Q000032:analysis; D001230:Aspergillus / Q000302:isolation & purification*; D005189:False Positive Reactions; D005690:Galactose / Q000031:analogs & derivatives; D006801:Humans; D008351:Mannans / Q000032:analysis*; D008828:Microbiological Techniques; D010397:Penicillanic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives; D010878:Piperacillin / Q000009:adverse effects*; D000077725:Piperacillin, Tazobactam Drug Combination; D012680:Sensitivity and Specificity
D000900:Anti-Bacterial Agents; D000946:Antigens, Fungal; D008351:Mannans; C012990:galactomannan; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin; D005690:Galactose