Microcirculatory assessment of vascular acrosyndrome in anorexia nervosa and analysis of manifestation factors.
OBJECTIVE
Acrocyanosis (AC) is a common manifestation of starving syndrome in anorexia nervosa. We characterized microvascular changes associated with AC and determined discriminating factors between acrally symptomatic and nonsymptomatic patients.


METHODS
We examined 34 patients with anorexia nervosa (15 restrictive-anorectic type, 19 binge-eating/purging type, duration 1-25 years). Nineteen were symptomatic (SP) and 15 were nonsymptomatic (NSP). All underwent photo-pletysmography, sonography of the brachial artery, capillary microscopy and laboratory analysis.


RESULTS
Disease characteristics and body mass index did not differ between SP and NSP. In SP more dilated efferent capillary loops and venoles were present (P<.001) and capillary flow velocities were reduced (0.21+/-0.12 ml/min vs. 0.34+/-0.15 ml/min; P=.015). Flow-mediated and nitroglycerin-induced dilatation showed no differences. Symptomatic patients had lower leukocyte counts (P=.008), lower eosinophils (P=.003) and lower LDL (P=.045) concentrations. A logistic regression model identified only leukocytes (P=.017) and eosinophils (P=.023) to be associated with AC.


CONCLUSIONS
In acrally symptomatic patients the typical microvascular features of AC are present. AC is associated with lower leukocyte counts and lower eosinophils.
Klein-Weigel
Peter
P
Clinical Department of Vascular Surgery, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria. p-klein-weigel@ruppiner-kliniken.de
Rein
Patrick
P
Kronenberg
Florian
F
List
Eveline
E
Kinzl
Johann
J
Biebl
Wilfried
W
Fraedrich
Gustav
G
D000856:Anorexia Nervosa / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D015992:Body Mass Index; D002196:Capillaries / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002149:Energy Intake; D004804:Eosinophils; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016015:Logistic Models; D008297:Male; D008833:Microcirculation / Q000502:physiology*
D002784:Cholesterol