[Multiple cerebral tuberculomas resistant to conventional therapy in an immunocompromised subject].
A 33 years old immunocompromised woman was admitted for a fever of unknown origin during the last five months. She referred a body temperature up to 38.3 degrees C, headache, weakness. The physical examination revealed right homonymous hemianopia, hyperreflexia and Babinski on her right side. A TC scan and a following bioptic specimen showed multiple cerebral tuberculomas. A conventional therapy was started but no significative improvement was observed. She was finally treated with interferon gamma and GM-CSF in addition to the therapy with an important regression of the lesions and significative improvement of the fever and neurological findings.
Picardi
A
A
Navajas
F
F
Zardi
E M
EM
Scarlata
S
S
Spoto
S
S
Vespasiani Gentilucci
U
U
De Galasso
L
L
Sgambato
E
E
Costantino
S
S
D000328:Adult; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016862:Tuberculoma, Intracranial / Q000188:drug therapy* / Q000276:immunology