Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease.
We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both alpha-tocopherol and vitamin C.
Department Neurology, Oregon Health and Sciences University, Portland, OR, USA.
Joseph F
JF
Quinn
Kathleen S
KS
Montine
Milar
M
Moore
Jason D
JD
Morrow
Jeffrey A
JA
Kaye
Thomas J
TJ
Montine
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy; D000975:Antioxidants / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002552:Cerebral Ventricles / Q000473:pathology; D018450:Disease Progression; D028441:F2-Isoprostanes / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D013223:Statistics as Topic; D024502:alpha-Tocopherol / Q000008:administration & dosage; D016875:tau Proteins / Q000134:cerebrospinal fluid
D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D016875:tau Proteins; D024502:alpha-Tocopherol; D001205:Ascorbic Acid