Skin repair and scar formation: the central role of TGF-beta.
Wound healing is a complex process that we have only recently begun to understand. Central to wound repair is transforming growth factor beta (TGF-beta), a cytokine secreted by several different cell types involved in healing. TGF-beta has diverse effects, depending upon the tissue studied. This review focuses on healing in skin, particularly the phases of cutaneous wound repair and the role of TGF-beta in normal and impaired wound-healing models. It also explores TGF-beta activity in scarless foetal wound healing. Knowledge of TGF-beta function in scarless repair is critical to improving healing in clinical scenarios, such as diabetic wounds and hypertrophic scars.
Beanes
Steven R
SR
Department of Surgery, UCLA School of Medicine, LA 90095, USA. sbeanes@ucla.edu
Dang
Catherine
C
Soo
Chia
C
Ting
Kang
K
D002921:Cicatrix / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D012867:Skin / Q000473:pathology*; D012879:Skin Physiological Phenomena; D016212:Transforming Growth Factor beta / Q000502:physiology*; D014945:Wound Healing
D016212:Transforming Growth Factor beta