Reproductive system tumors in mice exposed to various types of fat perinatally.
Studies of human populations have produced conflicting evidence on whether increased intake of dietary fat increases the risk of female reproductive system cancer. Some animal studies have indicated that the perinatal period of development is the sensitive time for this effect. Since type of fat has been linked to cancer risk, the question is raised as to whether the perinatal period is also sensitive to type of fat. To test this question, mice were exposed perinatally to either corn oil, fish oil, olive oil, or lard, and tumor frequencies were determined for female offspring at the end of their lifespan. No significant differences were found between the 4 groups with respect to reproductive system tumor frequency. Also, there were no significant differences with respect to the variables of lifespan or body weight. Thus, there was no indication that the perinatal period of development was sensitive to type of fat with respect to carcinogenic effects.
Department of Radiology, Michigan State University, East Lansing, MI 48824-1316, USA.
Bruce E
BE
Walker
Stephanie N
SN
Edwards
D000375:Aging; D000818:Animals; D001835:Body Weight; D003314:Corn Oil / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D002149:Energy Intake; D005260:Female; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000453:epidemiology; D051379:Mice; D000069463:Olive Oil; D010051:Ovarian Neoplasms / Q000453:epidemiology; D010938:Plant Oils / Q000494:pharmacology; D014594:Uterine Neoplasms / Q000453:epidemiology
D004041:Dietary Fats; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D003314:Corn Oil; C029310:lard