4-isocyano-2,2,6,6-tetramethylpiperidin- 1-oxyl: a valuable precursor for the synthesis of new nitroxides.
To enrich the limited set of isonitriles typically employed, 4-isocyano-2,2,6,6-teramethylpiperidin-1-oxyl (1) is proposed as an isonitrile bearing a nitroxyl moiety. Isocyanide 1 was used in some reactions characteristic of isonitriles. Isoselenocyanate, amides (products of Passerini and Ugi reactions), and tetrazole derivative were obtained. The EPR spectra of the urea derivative 5b and a product of an Ugi reaction 7 (both dinitroxides) were analyzed. [structure: see text]
Zakrzewski
Jerzy
J
Institute of Industrial Organic Chemistry, 6 Annopol, 03-236 Warsaw, Poland. zakrzewski@ipo.waw.pl
Jezierska
Julia
J
Hupko
Jarosław
J