Role of xanthine oxidase in conduit artery endothelial dysfunction in cigarette smokers.
Xanthine oxidase contributes to oxidant stress and has been proposed as a risk factor for endothelial dysfunction. We studied the role of xanthine oxidase in conduit artery endothelial dysfunction in 12 smokers and 12 controls. Conduit artery vasodilation was impaired in smokers (4.3%) compared with controls (7.9%) (p = 0.006) and improved with xanthine oxidase inhibition in smokers (9.2%, p <0.001).
Department of Internal Medicine and General Clinical Research Center, University of Iowa College of Medicine, Iowa City, 52242, USA.
Sashi
S
Guthikonda
Kenneth
K
Woods
Christine A
CA
Sinkey
William G
WG
Haynes
D000328:Adult; D000368:Aged; D000493:Allopurinol / Q000494:pharmacology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D018592:Cross-Over Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D012907:Smoking / Q000503:physiopathology*; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors / Q000502:physiology*
D004791:Enzyme Inhibitors; D000493:Allopurinol; D014969:Xanthine Oxidase