Role of Bcl-2 family members in immunity and disease.
The different members of the Bcl-2 family are essential regulators of programmed cell death. These different members share one or more Bcl-2 homology domains, required for their ability to regulate each other. In this review, we describe current knowledge of the functions of different Bcl-2 members and their potential roles in disease and immunity.
Droin
Nathalie M
NM
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Green
Douglas R
DR
D000818:Animals; D005786:Gene Expression Regulation; D019337:Hematologic Neoplasms / Q000175:diagnosis; D006801:Humans; D007109:Immunity; D051379:Mice; D008822:Mice, Transgenic; D011379:Prognosis; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D019253:Proto-Oncogene Proteins c-bcl-2