Multiple endocrine neoplasia type 1 with unusual concomitance of various neoplastic disorders.
A patient with multiple endocrine neoplasia type 1 (MEN1) who manifested various MEN1-unrelated tumors was reported. The patient was a 43-year-old woman who manifested typical features of MEN1 including primary hyperparathyroidism, prolactinoma, adrenal adenoma and visceral lipomas. During the course, she also manifested chondrosarcoma, B cell lymphoma and mesothelioma. The patient had no apparent family history of MEN1 or any other neoplastic diseases. Genetic analysis of DNA from peripheral mononuclear cells of the patient revealed no germline mutations in MEN1 gene. Genetic instability due to yet unidentified cause is the possible explanation of occurrence of multiple tumors. Careful periodic screening of endocrine and other disorders for her siblings and children as well as for the patient is warranted.
Department of Aging Medicine and Geriatrics, Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Yoshihiro
Y
Nishimura
Koh
K
Yamashita
Wataru
W
Yumita
Masanori
M
Yamazaki
Miyuki
M
Katai
Akihiro
A
Sakurai
Kiyoshi
K
Hashizume
D000236:Adenoma / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000150:complications; D000328:Adult; D000477:Alkylating Agents / Q000494:pharmacology; D001859:Bone Neoplasms / Q000150:complications; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002813:Chondrosarcoma / Q000150:complications; D004852:Epoxy Compounds / Q000494:pharmacology; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications; D008067:Lipoma / Q000150:complications; D016393:Lymphoma, B-Cell / Q000150:complications; D008279:Magnetic Resonance Imaging; D008654:Mesothelioma / Q000150:complications; D009000:Monocytes / Q000502:physiology; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014057:Tomography, X-Ray Computed; D014781:Viscera
D000477:Alkylating Agents; D004852:Epoxy Compounds; C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins; C007366:diepoxybutane