[Effect of triple antiretroviral therapy on Tunisian AIDS profile: study of 139 cases].
We report a retrospective study to estimate highly active antiretroviral therapy (HAART) effect in 139 HIV infected patients. Four criteria are studied: prevalence of opportunistic infections, CD4 cell count evolution, viral load progression and mortality. Gastrointestinal side effects are the most common clinical adverse reaction (61.1 percent), and hematological side effects are the most common biological adverse reaction (61.2 percent). During the 22.8 months (3 months to 6 years) follow-up average period, CD4 cell counts remained above 500 per cubic millimeter in only 25.8 percent of cases, while 63.5 percent of patients had a viral load below 400 copies per milliliter. During the study on patients receiving HAART, opportunistic infections appeared in 17.3 percent of cases (24 cases) and mortality in 6.4 percent of cases.
Service des Maladies Infectieuses, Hôpital la Rabta, Tunis.
Fayçal
F
Zouiten
Lamia
L
Ammari
Ahmed
A
Goubantini
Hanène
H
Tiouiri
Amine
A
Slim
Ahmed
A
Maamouri
Badreddine
B
Kilani
Fakher
F
Kanoun
Chekib
C
Marrakchi
Nahed
N
Neifer
Leila
L
Mihoub
Faouzi
F
Jenhani
Mounira
M
Garbouj
Taoufik
T
Ben Chaabane
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014416:Tunisia; D019562:Viral Load