The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin.
The effect of a synthetic peptide (H92-G110) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p.
Laboratory of Pathophysiology, Butantan Institute, Av. Vital Brazil, 1500, São Paulo, SP 05503-900, Brazil.
Camila Squarzoni
CS
Dale
Luis Roberto de Camargo
LR
Gonçalves
Luiz
L
Juliano
Maria Aparecida
MA
Juliano
Ana Maria Moura
AM
da Silva
Renata
R
Giorgi
D000818:Animals; D040502:Calgranulin B / Q000737:chemistry* / Q000627:therapeutic use; D003435:Crotalid Venoms; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008666:Metalloendopeptidases; D051379:Mice / Q000378:metabolism*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D000097146:Bothrops jararaca Venom
D040502:Calgranulin B; D003435:Crotalid Venoms; D008666:Metalloendopeptidases; D010975:Platelet Aggregation Inhibitors; D000097146:Bothrops jararaca Venom