Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia.
Panic disorder is a common anxiety disorder which frequently co-occurs with agoraphobia. A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits. We investigated a possible association between this 5-HT1A gene promoter polymorphism and panic disorder by genotyping the 1019C>G single nucleotide polymorphism in 134 panic-disorder patients with and without agoraphobia and matched 134 controls. In our sample no significant evidence of allelic association in the combined panic-disorder group was found. However, our results show a significant association with the G allele in patients with panic disorder with agoraphobia (p=0.03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia.
Department of Psychiatry, University of Münster, Germany.
Claudia
C
Rothe
Lise
L
Gutknecht
Christine
C
Freitag
Ralf
R
Tauber
Rainald
R
Mössner
Petra
P
Franke
Jrgen
J
Fritze
Gerd
G
Wagner
Gregor
G
Peikert
Berit
B
Wenda
Philipp
P
Sand
Christian
C
Jacob
Marcella
M
Rietschel
Markus M
MM
Nöthen
Henk
H
Garritsen
Rolf
R
Fimmers
Jürgen
J
Deckert
Klaus-Peter
KP
Lesch
D000328:Adult; D000379:Agoraphobia / Q000235:genetics* / Q000523:psychology*; D000483:Alleles; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics* / Q000523:psychology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017931:DNA Primers; D044282:Receptor, Serotonin, 5-HT1A; D004247:DNA