Relationship between dentifrice fluoride concentration and clinical caries reduction.
OBJECTIVE
To review the published literature on clinical caries trials of fluoride dentifrices and to combine their results in order to evaluate the correlation between fluoride concentration in dentifrice formulations and their anticaries efficacy, i.e., the dose-response relationship.


METHODS
All available dentifrice caries clinical trials reported in the literature of products having at least two fluoride concentrations greater than 0 ppm were reviewed, graphed and statistically analyzed.


RESULTS
The evaluation supported a linear correlation between the fluoride concentration of dentifrices between 0 and 5000 ppm F and clinical caries efficacy.
Colgate-Palmolive Technology Center, Piscataway, New Jersey 08854, USA.
Edward A
EA
Tavss
James R
JR
Mellberg
Marilou
M
Joziak
Robert J
RJ
Gambogi
Steven W
SW
Fisher
D002327:Cariostatic Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005459:Fluorides / Q000008:administration & dosage*; D006801:Humans
D002327:Cariostatic Agents; D003802:Dentifrices; D005459:Fluorides