The management of Paget's disease of the breast.
Paget's disease of the breast is a relatively rare condition, accounting for 1% to 3% of primary breast cancers. It is associated with an underlying carcinoma, invasive or noninvasive (ductal carcinoma in situ), in most of the cases. Primary treatment is surgical with adjuvant therapy being dictated by the stage and nature of the underlying tumor. Modified radical mastectomy is the standard of care with breast conservation appropriate in a select group of patients with Paget's disease. This select group includes patients that are diagnosed with nipple-areola changes alone without evidence of a palpable mass or mammographic abnormality. In this group of patients, breast conservation offers local recurrence rates comparable to rates in patients with invasive or noninvasive cancers. In patients diagnosed with associated palpable masses or mammographic abnormalities suggestive of cancer, the recurrence rates are higher and mastectomy is warranted.
Marcus
Elizabeth
E
Division of Breast Oncology, John H. Stroger, Jr. Hospital of Cook County, Rush University, 1900 West Polk, Room 601, Chicago, IL 60612, USA. elizabeth.marcus@hektoen.org
D001943:Breast Neoplasms / Q000628:therapy*; D019468:Disease Management; D005260:Female; D006801:Humans; D010144:Paget's Disease, Mammary / Q000628:therapy*