Mucigerin, a new coumarin from Calophyllum mucigerum (Guttiferae).
Our recent studies on the stem bark of Calophyllum mucigerum (Guttiferae) have yielded a new coumarin mucigerin, a prenylated xanthone cudraxanthone C and the common steroidal triterpenes friedelin and stigmasterol. Structural elucidations of these compounds were achieved using 1H NMR, 13C NMR, DEPT, COSY, HETCOR and HMBC experiments while MS gave the molecular masses. Cytotoxic assays using CEM-SS cell line (T-lymphoblastic leukemia) on the crude extracts of the stem bark indicated some activity. The crude extracts were also found to be moderately toxic against the larvae of Aedes aegypti. This article reports the isolation and identification of mucigerin as well as bioassay data.
Department of Chemistry, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia. gwen@fsas.upm.edu.my
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D000330:Aedes; D000818:Animals; D001681:Biological Assay; D029759:Calophyllum / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D006801:Humans; D007814:Larva; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry; D014407:Tumor Cells, Cultured
D003374:Coumarins; C486121:mucigerin