Migraine aura: a knockin mouse with a knockout message.
Migraine aura is a sometimes disabling disorder of the brain that involves significant neurological symptoms in about 30% of patients. In this issue of Neuron, van den Maagdenberg et al. characterize a mouse with a knockin mutation known to cause familial hemiplegic migraine and provide evidence that a lowered threshold to the triggering of CSD may account for the devastating phenotype of familial hemiplegic migraine.
Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
Peter J
PJ
Goadsby
D000818:Animals; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D020325:Migraine with Aura / Q000235:genetics*; D009154:Mutation