Nonswelling macroporous synbeads for improved efficiency of solid-phase biotransformations.
An application of novel, highly porous nonswelling resins (Synbeads) for enzymatic catalysis on solid supports is reported. These new resins combine easy handling of the beads, chemical stability, improved accessibility of proteins and higher productivity relative to swelling polymers. The present study demonstrates that the resin porosity greatly affects the efficiency in solid-phase biotransformations and that Synbead resins are valuable alternatives to swelling polymers for solid-phase chemistry and biocatalysis. The present study investigates the influence of key parameters, such as porosity and reactive functional-group density, on the reaction efficiency.
Basso
Alessandra
A
Dipartimento di Scienze Farmaceutiche, Università degli Studi, Piazzale Europa 1, 34127 Trieste, Italy.
Braiuca
Paolo
P
De Martin
Luigi
L
Ebert
Cynthia
C
Gardossi
Lucia
L
Linda
Paolo
P
Verdelli
Silvia
S
Tam
Andrea
A