[Experimental research of NNB composite in repairing mandibular defects in rabbits].
OBJECTIVE
To study the effects of artificial bone composite of basic fibroblast growth factor(bFGF) with natural non organic bone(NNB)in repairing mandibular defects in rabbits,in order to provide an ideal bone replacement material for clinic.


METHODS
15mm x 6mm bilateral mandibular periosteum bone defects were made surgically in 30 New Zealand adult rabbits and each defect as an experimental unit. The defects were randomly repaired with composite bone, NNB,fresh autogenous bone at 3,6,12 weeks after surgery according to the total random design, blank control group was stayed. Specimens obtained were evaluated with general observation, X-ray as well as computerized histological microscopic analysis.


RESULTS
New bone formed and calcified earlier in composite bone and the bone area was greater in the same period than that in NNB. The new bone area in composite bone was still smaller than that of autogenous bone at 6 weeks, while at 12 weeks they had no significant differences. The blank defects were not repaired even in the end.


CONCLUSIONS
Composite bone had sound biocompatibility. It was much better than NNB and can be compared with autogenous bone 12 weeks after operation. So it can be an ideal alternative for bone replacement.
School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China. JiangXQ0510@sina.com
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Jiang
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Pan
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Liu
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