Bcl-2 proteins: master switches at the intersection of death signaling and the survival control by Raf kinases.
Bcl-2 family members are central to the control of cell survival. Work of the last years has established that the function of these proteins can be regulated by mitogenic signaling cascades. Within the scope of this review, we will discuss the contribution of Bcl-2-dependent signaling pathways to cell survival by Raf kinases and also address the underlying mechanisms.
Institut für Medizinische Strahlenkunde und Zellforschung (MSZ), Universität Würzburg, Versbacher Str. 5, 97078 Würzburg, Germany. rappur@mail.uni-wuerzburg.de
Ulf R
UR
Rapp
Ulrike
U
Rennefahrt
Jakob
J
Troppmair
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D008928:Mitochondria / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*; D019908:Proto-Oncogene Proteins c-raf / Q000502:physiology*; D015398:Signal Transduction
D019253:Proto-Oncogene Proteins c-bcl-2; D019908:Proto-Oncogene Proteins c-raf