Ozz; a new name on the long list of beta-catenin's nemeses.
In the February issue of Developmental Cell, Nastasi et al. describe Ozz, a muscle-specific ubiquitin ligase adaptor that regulates myofibril organization. Ozz appears to function in ubiquitination and degradation of membrane-bound, but not cytosolic, beta-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers.
Wu
Geng
G
Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
Liu
Chunming
C
He
Xi
X
D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D002454:Cell Differentiation; D002462:Cell Membrane / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008025:Ligases / Q000378:metabolism; D008954:Models, Biological; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009210:Myofibrils / Q000378:metabolism; D012518:Sarcomeres / Q000378:metabolism; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D051176:beta Catenin
D033942:Adaptor Proteins, Vesicular Transport; C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D009124:Muscle Proteins; C483082:NEURL2 protein, human; D015534:Trans-Activators; D025801:Ubiquitin; D051176:beta Catenin; D043743:Ubiquitin-Protein Ligase Complexes; D044767:Ubiquitin-Protein Ligases; D008025:Ligases