Studies on 1-O-acetylbritannilactone and its derivative, (2-O-butyloxime-3-phenyl)-propionyl-1-O-acetylbritannilactone ester.
The crystal structures of 1-O-acetylbritannilactone 6 isolated from Inula britannica, and its derivative (2-O-butyloxime-3-phenyl) propionyl 1-O-acetylbritannilactone ester 7 are reported. The structure of synthesized derivative 7 was established by spectroscopic methods. Both compounds inhibited the growth of human HL-60, Bel-7402 cell lines and compound 7 had the stronger cytotoxic activity.
Hebei University of Science and Technology, Shijiazhuan 050018, People's Republic of China.
Shouxin
S
Liu
He
H
Liu
Weiying
W
Yan
Li
L
Zhang
Naisheng
N
Bai
Chi-Tang
CT
Ho
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004952:Esters; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D038143:Inula; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004952:Esters; D006131:Growth Inhibitors; D007783:Lactones; C487680:acetylbritannilatone