Cyclooxygenase-2 inhibitor treatment of older osteoarthritis patients.
Nonsteroidal anti-inflammatory drugs are often prescribed to treat osteoarthritis. Two cyclooxygenase isoenzymes prompted the development selective COX-2 inhibitors. The development, efficacy, and toxicity of COX-2 inhibitor treatment of osteoarthritis are summarized.
VA Salt Lake City Health Care System, Divisions of Rheumatology and Geriatrics, University of Utah, Salt Lake City, Utah, USA.
Sara Jane
SJ
Andersen
D000367:Age Factors; D000368:Aged; D002318:Cardiovascular Diseases / Q000139:chemically induced; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D007674:Kidney Diseases / Q000139:chemically induced; D008565:Membrane Proteins; D010003:Osteoarthritis / Q000188:drug therapy*; D010437:Peptic Ulcer / Q000139:chemically induced; D011451:Prostaglandin-Endoperoxide Synthases; D012449:Safety
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases