In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography.
An ultrahigh-speed spectral domain optical coherence tomography (SD-OCT) system is presented that achieves acquisition rates of 29,300 depth profiles/s. The sensitivity of SD-OCT and time domain OCT (TD-OCT) are experimentally compared, demonstrating a 21.7-dB improvement of SD-OCT over TD-OCT. In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW.
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA.
Nader
N
Nassif
Barry
B
Cense
B Hyle
BH
Park
Seok H
SH
Yun
Teresa C
TC
Chen
Brett E
BE
Bouma
Guillermo J
GJ
Tearney
Johannes F
JF
de Boer
D006801:Humans; D008962:Models, Theoretical; D012160:Retina / Q000033:anatomy & histology*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods