A novel multicomponent reaction involving isocyanide, dimethyl acetylenedicarboxylate (DMAD), and electrophilic styrenes: facile synthesis of highly substituted cyclopentadienes.
Alkyl isocyanides, DMAD, and various activated styrenes furnish fully substituted cyclopentadienes in a one-pot three-component reaction. [reaction: see text]
Nair
Vijay
V
Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum, India. vijaynair_2001@yahoo.com
Menon
Rajeev S
RS
Beneesh
P B
PB
Sreekumar
V
V
Bindu
S
S