Autosomal trisomy and maternal use of multivitamin supplements.
Recent reports suggest that women carrying certain polymorphisms of folate genes associated with suboptimal folate status might be at increased risk for having a child with Down syndrome or other autosomal trisomies, and hypothesized that maternal use of multivitamin supplements might reduce such risk. To evaluate this hypothesis, we examined data from a population-based case-control study, and contrasted cases of Down syndrome, trisomy 18, and trisomy 13, with unaffected controls. Periconceptional multivitamin use, compared to no such use, was associated with an odds ratio (OR) of 0.9 (95% confidence interval [CI], 0.6-1.3) for having a pregnancy affected by an autosomal trisomy. The OR was 0.8 (95% CI, 0.5-1.3) for Down syndrome and 1.4 (95% CI, 0.5-3.6) for trisomies 13 and 18, with little variation by maternal race or age. Periconceptional multivitamin use was not associated with a major reduction in the risk for common autosomal trisomies.
Botto
Lorenzo D
LD
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. LBotto@cdc.gov
Mulinare
Joseph
J
Yang
Quanhe
Q
Liu
Yecai
Y
Erickson
J David
JD
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D019587:Dietary Supplements; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005828:Genetics, Population; D006801:Humans; D008423:Maternal Age; D016017:Odds Ratio; D011247:Pregnancy; D014314:Trisomy; D014815:Vitamins / Q000627:therapeutic use*
D014815:Vitamins