Pathway logic modeling of protein functional domains in signal transduction.
Protein functional domains (PFDs) are consensus sequences within signaling molecules that recognize and assemble other signaling components into complexes. Here we describe the application of an approach called Pathway Logic to the symbolic modeling signal transduction networks at the level of PFDs. These models are developed using Maude, a symbolic language founded on rewriting logic. Models can be queried (analyzed) using the execution, search and model-checking tools of Maude. We show how signal transduction processes can be modeled using Maude at very different levels of abstraction involving either an overall state of a protein or its PFDs and their interactions. The key insight for the latter is our algebraic representation of binding interactions as a graph.
SRI International, 333 Ravenswood Avenue, Menlo Park CA 94025, USA. ctalcott@sri.com
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Talcott
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Eker
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Knapp
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Lincoln
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Laderoute
D019295:Computational Biology; D004789:Enzyme Activation; D016015:Logistic Models; D008954:Models, Biological; D021382:Protein Sorting Signals / Q000502:physiology; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000502:physiology; D019908:Proto-Oncogene Proteins c-raf / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D021382:Protein Sorting Signals; D011506:Proteins; D019908:Proto-Oncogene Proteins c-raf