[Intake and excretion of cadmium and iron balance and influence of dietary habits among young women].
OBJECTIVE
Absorption of cadmium is increased by deficiency of iron in animals, but it is uncertain that the same phenomenon occurs in humans. The purpose of this study is to investigate the relationship between cadmium and iron in the body and to evaluate the influence of dietary habits.


METHODS
Twenty-five healthy women, aged 20-23 years, were selected by excluding those with renal disease and habitual constipation. They participated in the dietary intervention study to estimate tolerable weekly intake of Cd for 3 weeks in the same dormitory. At 3 months before, at 0 Day, at the 12th Day of the study and 9 months after the study, health check-ups were performed, and Cd in the blood and urine, hemoglobin (Hb), serum iron (iron) and serum ferritin (ferritin) were measured.


RESULTS
Cd concentration in the blood (B-Cd) showed a significant correlation with Cd concentration in the urine (U-Cd), and inverse correlation with the body iron storage, such as Hb, iron and ferritin. A food frequency questionnaire showed that no subject showed insufficient dietary intake of iron. Subjects who had eaten grain, millet and brown rice showed higher levels of B-Cd and U-Cd and low levels of Hb, iron and ferritin.


CONCLUSIONS
Absorption of Cd tended to increase according to a low level of body iron storage among healthy young women.
Murashima
Megumi
M
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo 156-8502, Japan.
Kikuchi
Yuriko
Y
Nomiyama
Tetsuo
T
Kumagai
Nami
N
Omae
Kazuyuki
K
Watanabe
Shaw
S
D000328:Adult; D002104:Cadmium / Q000008:administration & dosage* / Q000097:blood / Q000652:urine*; D004032:Diet; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000097:blood / Q000652:urine*; D019266:Iron, Dietary / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D013997:Time Factors
D006454:Hemoglobins; D019266:Iron, Dietary; D002104:Cadmium; D005293:Ferritins; D007501:Iron