[Clinical and laboratory investigation of four acute myeloid leukemia patients with t(3;3) translocation].
OBJECTIVE
To investigate the clinical and laboratory characteristics of four acute myeloid leukemia with t(3;3) translocation.


METHODS
Bone marrow cell chromosome karyotype analysis were carried out with direct method and short-term culture and R-banding technique.


RESULTS
Four AML patients with t(3;3) translocation were identified. They did not obtain complete remission after chemotherapy and the median survival time was 4.5 months.


CONCLUSIONS
t(3;3) translocation is a rare chromosome abnormality, which has mostly been found in myeloid leukemia and the prognosis of these patients is poor.
Chen
Zhi-mei
ZM
The First Affiliated Hospital of Medical College of Zhejiang University, Institute of Hematology, Hangzhou 310003, China.
Wu
Jian-guo
JG
Jin
Jie
J
Lou
Ji-yu
JY
Lin
Mao-fang
MF
D000328:Adult; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014178:Translocation, Genetic