Ubiquitin-dependent activation of NF-kappaB: K63-linked ubiquitin chains: a link to cancer?
Recent discoveries of the novel roles of lysine 63-linked polyubiquitin chains in the activation of NF-kappaB transcription factor shed new light on both the mechanistic aspects of this signal transduction pathway and its role in cancer.
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Zhijian J
ZJ
Chen
Serge Y
SY
Fuchs
D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D006801:Humans; D051550:I-kappa B Kinase; D016328:NF-kappa B / Q000096:biosynthesis* / Q000494:pharmacology*; D009369:Neoplasms / Q000503:physiopathology*; D017346:Protein Serine-Threonine Kinases / Q000494:pharmacology; D025801:Ubiquitin / Q000494:pharmacology*
D016328:NF-kappa B; D025801:Ubiquitin; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human