Migraine aura: a knockin mouse with a knockout message.
Migraine aura is a sometimes disabling disorder of the brain that involves significant neurological symptoms in about 30% of patients. In this issue of Neuron, van den Maagdenberg et al. characterize a mouse with a knockin mutation known to cause familial hemiplegic migraine and provide evidence that a lowered threshold to the triggering of CSD may account for the devastating phenotype of familial hemiplegic migraine.
Goadsby
Peter J
PJ
Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom.
D000818:Animals; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D020325:Migraine with Aura / Q000235:genetics*; D009154:Mutation