Sarcoid polyneuropathy responsive to intravenous immunoglobulin.
We describe a 38-year-old woman with a predominantly sensory axonal polyneuropathy in whom a nerve biopsy demonstrated sarcoid granulomas. The neuropathy did not respond to oral steroid therapy but there was a rapid and repeated response to intravenous immunoglobulin, which gradually diminished over subsequent treatments, but remained beneficial. The systemic sarcoidosis remained active.
Heaney
Dominic
D
Department of Neurology, Royal London Hospital, Whitechapel, London E1 1BB, UK.
Geddes
Jennian F
JF
Nagendren
Kulan
K
Swash
Michael
M
D000328:Adult; D018771:Arthralgia / Q000209:etiology / Q000473:pathology; D001706:Biopsy; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D009431:Neural Conduction / Q000502:physiology; D010292:Paresthesia / Q000209:etiology / Q000473:pathology / Q000628:therapy; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications*; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome; D014605:Uveitis / Q000209:etiology / Q000473:pathology
D016756:Immunoglobulins, Intravenous