Nitrosation of thiols and thioethers in the gas phase: a combined theoretical and experimental study.
Recent studies have demonstrated the biological importance of the interaction of nitric oxide with proteins such as cytochrome-c or hemoglobin. In particular, the possibility that the nitrosonium cation, NO(+), could reversibly bind to sulfide atom type was proposed. At pH values of biological relevance, nitrosation was proposed to occur through the action of NO(+) carriers such as nitrosothiols or nitrosamines. In this context, the gas phase chemistry of protonated nitrosothiols is studied in the present work by a combination of mass spectrometry and computational methods.
Gerbaux
Pascal
P
Organic Chemistry Laboratory, University of Mons-Hainaut, Mons, Belgium. pascal.gerbaux@umh.ac.be
Wantier
Pascale
P
Flammang
Robert
R
D000641:Ammonia / Q000737:chemistry; D005740:Gases / Q000737:chemistry*; D006862:Hydrogen Sulfide / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D008744:Methylamines / Q000737:chemistry; D015394:Molecular Structure; D009569:Nitric Oxide / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D005740:Gases; D008744:Methylamines; D009573:Nitrites; D013438:Sulfhydryl Compounds; D013440:Sulfides; D014867:Water; C005231:methylmercaptan; D009569:Nitric Oxide; D000641:Ammonia; C027451:methylamine; D000432:Methanol; D006862:Hydrogen Sulfide