CSF soluble Fas correlates with the severity of HIV-associated dementia.
Soluble Fas (sFas) and soluble Fas ligand (sFasL) are associated with cellular dysfunction and death and are elevated in CSF from patients with HIV dementia (HIV-D). The authors investigated whether these markers correlated with dementia severity and course. sFas and sFasL were measured in 15 highly active antiretroviral therapy (HAART)-naïve HIV-D subjects, 30 HAART-naïve HIV+ controls, and 17 HIV-controls. HIV-D subjects had higher CSF sFas levels than controls. Subjects with moderate/severe dementia had higher CSF sFas levels than those with mild dementia. CSF sFas trended lower in those with progressive dementia.
Department of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
A
A
Towfighi
R L
RL
Skolasky
C
C
St  Hillaire
K
K
Conant
J C
JC
McArthur
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000473:pathology; D000328:Adult; D017209:Apoptosis; D001253:Astrocytes / Q000473:pathology; D018450:Disease Progression; D053222:Fas Ligand Protein; D005260:Female; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000523:psychology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012995:Solubility; D019014:fas Receptor / Q000134:cerebrospinal fluid*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor