[Biomechanic shear stress in carotid arteries and atherosclerosis development].
One of the major hemodynamic forces acting on blood vessels is shear stress, which is, the friction force between the endothelial cell surface and flowing blood. Arterial shear stress within physiologic range (15-70 dyne/cm2) induces endothelial quiescence and an atheroprotective gene expression profile. Low shear stress (< 4 dyne/cm2) stimulates atherogenic phenotype, whereas, high shear stress (> 70 dyne/cm2) induce prothrombotic state.
Pracownia Chorób Naczyniowych Układu Nerwowego, Katedra i Klinika Neurologii Akademii Medycznej im. K. Marcinkowskiego w Poznaniu. R.Kazmierski@am.poznan.pl
Radosław
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Kaźmierski
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D002339:Carotid Arteries / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D015870:Gene Expression; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D010641:Phenotype; D033081:Shear Strength; D013312:Stress, Physiological