Anti-GQ1b antibody as a factor predictive of mechanical ventilation in Guillain-Barré syndrome.
Compared with 87 unventilated patients with Guillain-Barré syndrome (GBS), 44 ventilated patients with GBS more frequently had multiple cranial nerve involvement (91 vs 50%; p < 0.001) and IgG anti-GQ1b antibody (27 vs 8%; p = 0.006). In GBS patients without ophthalmoparesis, the presence of IgG anti-GQ1b antibody was associated with respiratory failure (12 [3/25] vs 0% [0/67]; p = 0.04). The presence of the antibody may be a factor predictive of respiratory failure in GBS.
Third Department of Internal Medicine, National Defense Medical College, Saitama-ken, University of Tokyo, Japan.
K
K
Kaida
S
S
Kusunoki
M
M
Kanzaki
K
K
Kamakura
K
K
Motoyoshi
I
I
Kanazawa
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D005732:Gangliosides; D007074:Immunoglobulin G; C039129:GQ1b ganglioside