New steroidal dimers with antifungal and antiproliferative activity.
Bile acid-derived novel amphiphilic topology was designed and synthesized in the form of steroidal dimers. These dimers were tested for antifungal and antiproliferative activity in vitro. N(1),N(3)-Diethylenetriaminebis[cholic acid amide] was found to be active against C. albicans, Y. lipolytica, and B. poitrassi at nanomolar concentration and did not show any effect on cell proliferation. N(1),N(2)-Ethylenediaminebis[deoxycholic acid amide] totally inhibited the growth of human oral cancer (HEp-2) and human breast cancer (MCF-7) cells.
Organic Chemistry Synthesis Division, National Chemical Laboratory, Pune 411 008, India.
Deepak B
DB
Salunke
Braja G
BG
Hazra
Vandana S
VS
Pore
Manoj Kumar
MK
Bhat
Pallavi B
PB
Nahar
Mukund V
MV
Deshpande
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001647:Bile Acids and Salts / Q000737:chemistry*; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D045744:Cell Line, Tumor; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D005658:Fungi / Q000187:drug effects; D006801:Humans; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D025062:Yarrowia / Q000187:drug effects
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001647:Bile Acids and Salts; D013256:Steroids