Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia.
Panic disorder is a common anxiety disorder which frequently co-occurs with agoraphobia. A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits. We investigated a possible association between this 5-HT1A gene promoter polymorphism and panic disorder by genotyping the 1019C>G single nucleotide polymorphism in 134 panic-disorder patients with and without agoraphobia and matched 134 controls. In our sample no significant evidence of allelic association in the combined panic-disorder group was found. However, our results show a significant association with the G allele in patients with panic disorder with agoraphobia (p=0.03, n=101). In conclusion, our findings do not support a major contribution of this polymorphism to the pathogenesis of panic disorder, but provide evidence for a possible role in the subgroup with agoraphobia.
Rothe
Claudia
C
Department of Psychiatry, University of Münster, Germany.
Gutknecht
Lise
L
Freitag
Christine
C
Tauber
Ralf
R
Mössner
Rainald
R
Franke
Petra
P
Fritze
Jrgen
J
Wagner
Gerd
G
Peikert
Gregor
G
Wenda
Berit
B
Sand
Philipp
P
Jacob
Christian
C
Rietschel
Marcella
M
Nöthen
Markus M
MM
Garritsen
Henk
H
Fimmers
Rolf
R
Deckert
Jürgen
J
Lesch
Klaus-Peter
KP
D000328:Adult; D000379:Agoraphobia / Q000235:genetics* / Q000523:psychology*; D000483:Alleles; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics* / Q000523:psychology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D011569:Psychiatric Status Rating Scales; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017931:DNA Primers; D044282:Receptor, Serotonin, 5-HT1A; D004247:DNA