Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians.
The renin-angiotensin system plays an important role in cardiovascular regulation. Abnormalities in genetic components of this system, such as the angiotensin-converting enzyme (ACE) gene, angiotensin II type 1 (AT1) receptor gene and angiotensinogen (AGT) gene, may cause a variety of adverse cardiovascular effects. It was the aim of this study, therefore, to investigate the involvement of the ACE insertion/deletion (I/D), AT1 receptor 1166 A->C and AGT M235T polymorphisms as predisposing factors for myocardial infarction (MI) in 195 young South African Indians (</= 45 years). Results were compared with those obtained I n 107 unaffected siblings (18-45 years old) and 300 healthy age- and race-matched control subjects. The distribution of the ACE genotypes was the same in each of the three study groups (p-value ranged between 0.83 and 0.98). No differences were observed in the 1166 A->C AT1 receptor polymorphism with respect to both genotype and allelotype (p > 0.70), or in the genotype or allele frequency distribution of the AGT M235T polymorphism (p > 0.44). However, a significant in crease was noted for both the AT1 receptor C variant (p = 0.025) and the AGT T variant (p = 0.047) in hypertensive patients compared with those who were normotensive. In conclusion, results of this study indicate that the ACE I/D, the 1166 A->C AT1 receptor and AGT M235T polymorphisms do not confer any increased risk for MI in young South African Indians.
Department of Medicine and the Coronary Care Unit, R.K. Khan Hospital, Nelson R. Mandela School of Medicine, University of Natal, Durban, South Africa.
N
N
Ranjith
R J
RJ
Pegoraro
L
L
Rom
P A
PA
Lanning
D P
DP
Naidoo
D000293:Adolescent; D000328:Adult; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics; D005192:Family Health; D017353:Gene Deletion; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007194:India / Q000208:ethnology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*; D013019:South Africa / Q000208:ethnology; D013223:Statistics as Topic
D005819:Genetic Markers; D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A