Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behçet's disease.
Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behçet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.
Yang
X
X
Gastroenterology Unit, University of Oxford, Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK.
Ahmad
T
T
Gogus
F
F
Verity
D
D
Wallace
G R
GR
Madanat
W
W
Kanawati
C A
CA
Stanford
M R
MR
Fortune
F
F
Jewell
D P
DP
Marshall
S E
SE
D000483:Alleles; D018912:Arabs; D001528:Behcet Syndrome / Q000235:genetics*; D015331:Cohort Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D059949:HLA-B51 Antigen; D006801:Humans; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine / Q000378:metabolism; D014421:Turkey; D006113:United Kingdom; D044465:White People
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D019713:Receptors, CCR5; D019707:Receptors, Chemokine