Composite of Au nanoparticles and molecularly imprinted polymer as a sensing material.
A molecularly imprinted polymer with immobilized Au nanoparticles (Au-MIP) is reported as a novel type of sensing material. The sensing mechanism is based upon the variable proximity of the Au nanoparticles immobilized in the imprinted polymer, which exhibits selective binding of a given analyte accompanied by swelling that causes a blue-shift in the plasmon absorption band of the immobilized Au nanoparticles. Using adrenaline as the model analyte, it was shown that molecular imprinting effectively enhanced the sensitivity and selectivity, and accordingly, Au-MIP selectively detects the analyte at 5 microM. The combination of molecular imprinting and the Au nanoparticle-based sensing system was shown to be a general strategy for constructing sensing materials in a tailor-made fashion due to wide applicability of the imprinting technique and the independence of the sensing mechanism from the analyte recognition system.
High Technology Research Center, Department of Chemistry, Faculty of Science and Engineering, and Frontier Institute for Biomolecular Engineering Research, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Jun
J
Matsui
Kensuke
K
Akamatsu
Shingo
S
Nishiguchi
Daisuke
D
Miyoshi
Hidemi
H
Nawafune
Katsuyuki
K
Tamaki
Naoki
N
Sugimoto
D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods*; D004837:Epinephrine / Q000032:analysis; D006046:Gold; D036103:Nanotechnology / Q000295:instrumentation*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012996:Solutions / Q000737:chemistry; D013696:Temperature
D011108:Polymers; D012996:Solutions; D006046:Gold; D004837:Epinephrine