[Studies on formulations of Panax notoginsenosides for intranasal administration].
OBJECTIVE
To develop high bioavailability preparations without irritation for Panax notoginsenosides.


METHODS
The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined.


RESULTS
Saponins of Panax notoginseng (PNS) was absorbed in rabbits more when administered intranasally than through other routines, and the formulations including MCC both gave high bioavailability and low irritation.


CONCLUSIONS
Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.
Xu
Qing-fang
QF
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China.
Fang
Xiao-ling
XL
Chen
Dao-feng
DF
Li
Jun-chan
JC
D000281:Administration, Intranasal; D000818:Animals; D001682:Biological Availability; D002023:Bufo bufo; D002482:Cellulose / Q000633:toxicity; D003505:Cyclodextrins; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D036145:Ginsenosides / Q000008:administration & dosage* / Q000302:isolation & purification / Q000493:pharmacokinetics*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D005894:Panax / Q000737:chemistry*; D010539:Permeability; D011817:Rabbits; D051381:Rats; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004337:Drug Carriers; D036145:Ginsenosides; D047392:beta-Cyclodextrins; D002482:Cellulose; C031215:betadex; C109691:microcrystalline cellulose