In vivo determination of prostatic zinc: phantom feasibility study.
This paper describes a phantom-based feasibility study for a potential in vivo determination of zinc in prostate, which could bring about improved diagnosis of prostate cancer. An x-ray fluorescence topographic technique was developed, which will permit determination of the Zn content in the prostate through the rectum, namely behind a 2-3 mm thick layer of the rectal wall. The topographic approach, together with a reconstruction method developed here, minimizes the interference of Zn from non-prostatic tissue. The phantom studies show that it will be possible to determine Zn in a prostatic compartment behind a few mm thick layer of tissue using a specially designed transrectal probe. Such a probe is currently under development in our laboratories.
Shilstein
S Sh
SSh
Weizmann Institute of Science, Rehovot 76100, Israel.
Breskin
A
A
Chechik
R
R
Feldman
G
G
Vartsky
D
D
D005240:Feasibility Studies; D006801:Humans; D008297:Male; D019047:Phantoms, Imaging; D011467:Prostate / Q000737:chemistry / Q000000981:diagnostic imaging*; D011469:Prostatic Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011859:Radiography; D013052:Spectrometry, X-Ray Emission / Q000379:methods*; D015032:Zinc / Q000032:analysis*
D015032:Zinc