Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia.
The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA.
Vaibhav A
VA
Diwadkar
Michael D
MD
DeBellis
John A
JA
Sweeney
Jay W
JW
Pettegrew
Matcheri S
MS
Keshavan
D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D001931:Brain Mapping; D010054:Brief Psychiatric Rating Scale; D016009:Chi-Square Distribution; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology; D012569:Schizotypal Personality Disorder / Q000209:etiology / Q000473:pathology