[Experimental study of tongxinluo capsule on restraining myocardial cell apoptosis due to ischemia/reperfusion].
OBJECTIVE
To find out the mechanism of Tongxinluo Capsule on anti-apoptosis of cardiac myocyte due to ischemia/reperfusion.


METHODS
Mouse myocardium of ischemia/reperfusion model was observed for evaluating the activity of superoxide dismutase (SOD), the level of malondialdehyde (MDA), the apoptotic index of cardial myocyte and the expression of apoptosis correlation protein bcl-2 and bax.


RESULTS
Tongxinluo Capsule could raise the activity of SOD and decrease the level of MDA. And it could depress cardial myocyte apoptosis caused by ischemia/reperfusion through up-regulating bcl-2 expression and down-regulating bax expression.


CONCLUSIONS
Tongxinluo Capsule could protect cardial myocyte well to avoid injury due to ischemia and reperfusion.
First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080.
Jian
J
Qin
Hongjian
H
Liu
Guozhen
G
Wu
Minghua
M
Jin
Shijun
S
Zhang
Weijun
W
Zhang
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D015428:Myocardial Reperfusion Injury / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase