A convenient procedure for bismuth-mediated Barbier-type allylation of aldehydes in water containing fluoride ions.
A new and convenient procedure for synthesis of homoallylic alcohols in generally good to excellent yields has been developed. The bismuth-mediated Barbier-type allylation of aldehydes (aromatic, aliphatic, alicyclic and heterocyclic) with allyl bromide has been carried out smoothly in water in the presence of fluoride ions.
Centre for Clean Chemistry, Department of Chemistry, University of Wales Swansea, Singleton Park, Swansea, UK SA2 8PP.
Keith
K
Smith
Sandra
S
Lock
Gamal A
GA
El-Hiti
Makoto
M
Wada
Norikazu
N
Miyoshi