Long-term survivors of ovarian malignancies after cisplatin-based chemotherapy; cardiovascular risk factors and signs of vascular damage.
Male germ cell tumour patients treated with cisplatin-based chemotherapy frequently develop cardiovascular risk factors and disease, but sparse information is available about long-term complications of this type of chemotherapy in women. We investigated the prevalence of cardiovascular risk factors and vascular damage in 21 women (median age 39 years; range 26-57 years) with an epithelial or germ cell tumour of the ovary cured by cisplatin-based chemotherapy after a median follow-up of 14 years (range 3-21 years). Hypercholesterolaemia was present in 62%, obesity in 24%, hypertension in 14%, insulin resistance in 14%, and microalbuminuria in 24% of patients. Microalbuminuria was more frequent in long-term cancer survivors than in a female background population with a similar age (23.8 versus 3.2%; P<0.05). A substantial portion of young female patients cured by cisplatin-based chemotherapy are likely to develop cardiovascular risk factors and signs of endothelial damage at an early stage.
de Vos
F Y F L
FY
Department of Medical Oncology, University Medical Center Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands.
Nuver
J
J
Willemse
P H B
PH
van der Zee
A G J
AG
Messerschmidt
J
J
Burgerhof
J G M
JG
de Vries
E G E
EG
Gietema
J A
JA
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D002784:Cholesterol / Q000097:blood; D002945:Cisplatin / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D018237:Germinoma / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy*; D012307:Risk Factors; D017741:Survivors
D000970:Antineoplastic Agents; D002784:Cholesterol; D002945:Cisplatin