Antimycobacterial Naphthopyrones from Senna obliqua.
Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 microg/mL against Mycobacteriatuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
James G
JG
Graham
Hongjie
H
Zhang
Susan L
SL
Pendland
Bernard D
BD
Santarsiero
Andrew D
AD
Mesecar
Fernando
F
Cabieses
Norman R
NR
Farnsworth
D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010568:Peru; D010946:Plants, Medicinal / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029846:Senna Plant / Q000737:chemistry*
D000995:Antitubercular Agents; D009284:Naphthols; D011753:Pyrones; C015497:rubrofusarin; C015486:quinquangulin