Toxoplasma gondii and mucosal immunity.
Toxoplasma gondii, an intracellular parasite infects the host through the oral route. Infection induces a cascade of immunological events that involve both the components of the innate and adaptative immune responses. Alteration of the homeostatic balance of infected intestine results in an acute inflammatory ileitis in certain strains of inbred mice. Both the infected enterocytes as well as the CD4 T cells from the lamina propria produce chemokines and cytokines that are necessary to clear the parasite whereas CD8 intraepithelial lymphocytes secrete transforming growth factor beta that reduces the inflammation. In this review, we describe the salient features of this complex network of interactions among the different components of the gut-associated lymphoid tissue cell population that are induced after oral infection with T. gondii.
Kasper
Lloyd
L
Department of Microbiology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Courret
Nathalie
N
Darche
Sylvie
S
Luangsay
Souphalone
S
Mennechet
Franck
F
Minns
Laurie
L
Rachinel
Nicolas
N
Ronet
Catherine
C
Buzoni-Gatel
Dominique
D
D000818:Animals; D016207:Cytokines / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology*
D016207:Cytokines