International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor.
Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are not only potent chemotaxins but also elicit oxygen radical production as well as induce secretory events in different cells. The most potent native ligand reported is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and the cell membrane receptor activated has now been cloned. This receptor is distinct from those receptors activated by either the prostaglandins or the leukotrienes. The purpose of this review is to briefly summarize the molecular evidence and highlight the significance of this receptor. In addition, an official nomenclature for this oxoeicosanoid receptor is proposed.
Brink
Charles
C
Centre National de la Recherche Scientifique UMR 7131, Hôpital Broussais, Bâtiment Les Mariniers, Paris, France. charlesbrink@hotmail.com
Dahlén
Sven-Erik
SE
Drazen
Jeffrey
J
Evans
Jilly F
JF
Hay
Douglas W P
DW
Rovati
G Enrico
GE
Serhan
Charles N
CN
Shimizu
Takao
T
Yokomizo
Takehiko
T
D000595:Amino Acid Sequence; D000818:Animals; D001095:Arachidonic Acids / Q000145:classification / Q000235:genetics / Q000378:metabolism; D015777:Eicosanoids / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D018055:Receptors, Eicosanoid / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D009626:Terminology as Topic
D001095:Arachidonic Acids; D015777:Eicosanoids; D018055:Receptors, Eicosanoid