Control of proliferation by Bcl-2 family members.
The anti-proliferative effect of Bcl-2 acts mainly at the level of the G0/G1 phase of the cell cycle. Deletions and point mutations in the bcl-2 gene show that the anti-proliferative activity of Bcl-2, can in some cases, be dissociated from its anti-apoptotic function. This indicates that the effect of Bcl-2 on cell cycle progression can be a direct effect and not only a consequence of its anti-apoptotic activity. Bcl-2 appears to mediate its anti-proliferative effect by acting on both signal transduction pathways (NFAT, ERK) and on specific cell cycle regulators (p27, p130).
Bonnefoy-Berard
Nathalie
N
INSERM U503, Centre d'étude et de Recherche en Virologie et Immunologie, 21 Avenue Tony Garnier 69365 Lyon Cedex 07, France.
Aouacheria
Abdel
A
Verschelde
Claire
C
Quemeneur
Laurence
L
Marçais
Antoine
A
Marvel
Jacqueline
J
D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction
D018797:Cell Cycle Proteins; D019253:Proto-Oncogene Proteins c-bcl-2