[Histological evaluation of domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration].
OBJECTIVE
To evaluate the possibility of domestic poly-DL-lactic acid membranes as barriers during periodontal guided tissue regeneration.


METHODS
Two-wall intrabony defects were made by artificially removing buccal and distal alveolar bone from the distal roots of the second, third and fourth mandibular premolars as well as the first mandibular molars of dogs. These experiment defects received four membranes (PDLLA, ePTFE, COL, Vicryl ) respectively for GTR, the control treated without membrane. Animals were sacrificed for histological evaluation and histometric analysis 2,4,8 weeks after surgery.


RESULTS
Domestic poly-DL-lactic acid membranes for periodontal guided tissue regeneration only induce a non-specific inflammation, which began its bioresorption at 4 weeks after surgery. Just like the other GTR materials including Vicryl mesh,domestic poly-DL-lactic acid membrane acts as barrier preventing the apical downgrowth of gingival epithelium and prompting periodontal tissue regeneration. As compared with the control, PDLLA exhibited its more effects 4 weeks after surgery, there is statistically difference between them.


CONCLUSIONS
Domestic poly-DL-lactic acid membranes exhibit excellent biocompatibility, as a guided tissue regenerative materials, it may have beneficial effects in the treatment of 2-wall periodontal intrabony defects.
Department of Oral Medicine, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Yuan-zheng
YZ
Yin
Rong
R
Shu
Xiao-feng
XF
Liu
Zheng
Z
Liu