A quenched molecular dynamics-rotating frame Overhauser spectroscopy study of a series of semibiosynthetically monoacylated anthocyanins.
Quenched molecular dynamics (QMD), in conjunction with NMR (ROESY) studies, was used to investigate the conformational behavior of some semibiosynthetic anthocyanins of the type 6-O-acyl-beta-D-Glcp-(166)-beta-D-Galp-(1-->O(3))-cyanidin, with and without a beta-D-Xylp branch at the 2-O-Gal position. These compounds, which are produced by the addition of selected carboxylic acids to growing tissue cultures of Daucus carota (wild carrot), are of interest as color-stabilized anthocyanins, some of which have potential as useful colorants in the nutraceutical and pharmaceutical industries. The QMD-ROESY studies, performed for the first time on anthocyanins, have led to the identification of families of conformers of these flexible molecules that are of interest in work toward determining the mechanism for stabilization of color among these compounds in solution.
Whittemore
Neil A
NA
Department of Chemistry, The University of Tennessee, Knoxville, Tennessee 37996, USA. dcbaker@utk.edu
Welch
Karen T
KT
Cox
James R
JR
Dougall
Donald K
DK
Baker
David C
DC
D000215:Acylation; D000872:Anthocyanins / Q000737:chemistry* / Q000302:isolation & purification*; D002236:Carbohydrate Conformation; D018552:Daucus carota / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure
D000872:Anthocyanins