[Phenobarbital rheumatism associated with gouty arthritis. Case report with 18-month follow-up].
Anticonvulsivant-induced rheumatism has been described in the literature mostly in relation to phenobarbital therapy. We report the case of an 85-year-old male affected by generalized seizures and treated with phenobarbital for some months, who came to our observation on account of a long-lasting arthropathy which was diagnosed as unknown gouty arthritis. After treatment however, a clinical picture of shoulder-hand syndrome persisted: this latter disappeared after substitution of phenobarbital with phenytoin. The association of a syndrome of rheumatism induced by barbiturates with gouty arthritis has not been previously described in the literature.
Fondazione Salvatore Maugeri I.R.C.C.S. Istituto Scientifico di Castel Goffredo, Mantova. gsaviola@fsm.it
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D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D015210:Arthritis, Gouty / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002908:Chronic Disease; D004829:Epilepsy, Generalized / Q000188:drug therapy*; D005500:Follow-Up Studies; D006074:Gout Suppressants / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects* / Q000627:therapeutic use; D010672:Phenytoin / Q000008:administration & dosage / Q000627:therapeutic use; D012019:Reflex Sympathetic Dystrophy / Q000150:complications; D012216:Rheumatic Diseases / Q000139:chemically induced* / Q000150:complications; D013997:Time Factors
D000927:Anticonvulsants; D006074:Gout Suppressants; D010672:Phenytoin; D000493:Allopurinol; D010634:Phenobarbital