[Uteroglobin G38A polymorphism is associated with the progression of IgA nephropathy in Chinese patients].
OBJECTIVE
Uteroglobin is a multifunctional protein. Both uteroglobin gene knockout and antisense transgenic mouse models developed the pathological and clinical features of IgA nephropathy. Uteroglobin G38A polymorphism has been reported to be associated with the progression of IgA nephropathy in some Caucasian and Asian populations, but there are no documents on Chinese population. The present report was to investigate the associations of uteroglobin G38A polymorphism with the development and progression of IgA nephropathy in Chinese patients.


METHODS
Three hundred patients with biopsy proven IgA nephropathy were identified from Renal Disease database. Ninety-three patients had been followed-up for 2-6 years. 145 healthy donors served as normal controls. Genomic DNAs were extracted from peripheral blood leucocytes. The uteroglobin G38A polymorphism was determined by PCR-RFLP. Uteroglobin G38A genotype and allele frequency were compared between patients with IgA nephropathy and normal controls. In addition, associations of G38A polymorphism with blood pressure, hematuria, proteinuria, pathological lesions and prognosis of renal function were analyzed in patients with IgA nephropathy.


RESULTS
Distribution of uteroglobin G38A polymorphism in patients with IgA nephropathy (38AA: 13.2%; 38AG: 57.6%; 38GG: 30.2%) and normal controls (38AA: 18.2%; 38AG: 60%; 38GG: 21.8%; P > 0.05) showed no difference. But patients with the 38AA genotype showed a higher odds ratio for progression of renal function (OR = 2.37, 95% CI = 1.12-5.01) as compared to patients with the 38AG/GG genotype.


CONCLUSIONS
Uteroglobin G38A polymorphism had no association with the development of IgA nephropathy, but the homogeneous 38AA genotype maybe one of the genetic markers for disease progression in Chinese IgA nephropathy.
Renal Division of Peking University First Hospital and Peking University Institute of Nephrology, Beijing 100034, China.
Ji-cheng
JC
Lü
Hong
H
Zhang
Yu-qing
YQ
Chen
Gang
G
Liu
Hai-yan
HY
Wang
D000328:Adult; D002681:China; D018450:Disease Progression; D005091:Exons / Q000235:genetics; D005260:Female; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011379:Prognosis; D016019:Survival Analysis; D014598:Uteroglobin / Q000235:genetics*
D014598:Uteroglobin