The peroxisome: orchestrating important developmental decisions from inside the cell.
The peroxisome has long been known for its role in lipid metabolism and hydrogen peroxide detoxification. However, growing evidence supports the view that this organelle can also function both as an intracellular signaling compartment and as an organizing platform that orchestrates certain developmental decisions from inside the cell. This review highlights various strategies that peroxisomes employ to regulate the processes of development, differentiation, and morphogenesis and critically evaluates several molecular mechanisms by which peroxisomes promote these processes.
Titorenko
Vladimir I
VI
Department of Biology, Concordia University, 7141 Sherbrooke St., West SP Building, Room SP-501-9, Montreal, Quebec H4B 1R6, Canada. VTITOR@vax2.concordia.ca
Rachubinski
Richard A
RA
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D005658:Fungi / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism; D009024:Morphogenesis / Q000502:physiology; D020675:Peroxisomes / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D018406:Virus Physiological Phenomena