Cloning: questions answered and unsolved.
Cloning by the transfer of adult somatic cell nuclei to oocytes has produced viable offspring in a variety of mammalian species. The technology is still in its initial stages of development. Studies to date have answered several basic questions related to such issues as genome potency, life expectancy of clones, mitochondrial fates, and feasibility of inter-species nuclear transfer. They have also raised new questions related to the control of nuclear reprogramming and function. These questions are reviewed here.
The Fels Institute for Cancer Research and Molecular Biology and Department of Biochemistry, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, USA. klatham@temple.edu
Keith E
KE
Latham
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D016922:Cellular Senescence / Q000502:physiology; D019976:Cloning, Organism / Q000379:methods / Q000639:trends*; D003247:Conservation of Natural Resources / Q000639:trends; D003593:Cytoplasm / Q000235:genetics; D004622:Embryo, Mammalian / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D018014:Gene Transfer Techniques; D016678:Genome; D006801:Humans; D011323:Primates / Q000502:physiology