Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand.
The relationship of the platelet-mediated autoagglutination of Plasmodium falciparum-infected red blood cells (IRBCs) to disease severity was investigated in 182 Thai patients with falciparum malaria; it was evident in 43% of uncomplicated malaria (n=63), 41% of severe malaria (n=104), and 100% of cerebral malaria (n=15; P=.001) isolates. The median (range) number of IRBCs in agglutinates per 1000 IRBCs was significantly higher in cerebral malaria (6 [3-42]) than in severe (0 [0-52]) and uncomplicated (0 [0-24]) malaria (P=.01). In multivariate analyses, high parasitemia and cerebral malaria were associated independently with parasite agglutination.
Chotivanich
Kesinee
K
Faculty of Tropical Medicine, Faculty of Science, Mahidol University, Bangkok, Thailand.
Sritabal
Juntima
J
Udomsangpetch
Rachanee
R
Newton
Paul
P
Stepniewska
Katarzyna A
KA
Ruangveerayuth
Ronatrai
R
Looareesuwan
Sornchai
S
Roberts
David J
DJ
White
Nicholas J
NJ
D000328:Adult; D000371:Agglutination; D001792:Blood Platelets / Q000502:physiology*; D018955:CD36 Antigens / Q000502:physiology; D004903:Erythrocyte Aggregation; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology*; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood*; D012397:Rosette Formation; D012720:Severity of Illness Index
D018955:CD36 Antigens