Design, synthesis and structure-activity relationship of novel RXR-selective modulators.
The synthesis and in vitro characterization of novel RXR-selective ligands possessing various substituted 1-benzofuran or 1-benzothiophene moieties are described.
Michellys
Pierre-Yves
PY
Department of Medicinal Chemistry, Ligand Pharmaceuticals Incorporated, 10275 Science Center Drive, San Diego, CA 92121, USA. pmichellys@gnf.org
D'Arrigo
Jennifer
J
Grese
Timothy A
TA
Karanewsky
Donald S
DS
Leibowitz
Mark D
MD
Mais
Dale A
DA
Mapes
Christopher M
CM
Reifel-Miller
Anne
A
Rungta
Deepa
D
Boehm
Marcus F
MF
D015195:Drug Design; D011485:Protein Binding / Q000502:physiology; D018168:Receptors, Retinoic Acid / Q000378:metabolism*; D047488:Retinoid X Receptors; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000378:metabolism*; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000378:metabolism*
D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D014157:Transcription Factors; D014212:Tretinoin