Device-related infections in critically ill patients. Part II: Prevention of ventilator-associated pneumonia and urinary tract infections.
Device utilization in critically ill patients is responsible for a high risk of complications such as catheter-related bloodstream infections (CRBSI), ventilator-associated pneumonia (VAP) and urinary tract infections (UTI). In this article we will review the current status of data regarding the prevention of VAP and UTI. The results of the more recent (5 years) randomized controlled trials are reviewed and discussed. General recommendations include staff education and use of a surveillance program with a restrictive antibiotic policy. Adequate time must be allowed for hand washing and barrier precautions must always be used during device manipulation. Specific measures for VAP prevention are: 1) use of multi-use, closed-system suction catheters; 2) no routine change of the breathing circuit; 3) lubrication of the cuff of the endotracheal tube (ET) with a water-soluble gel; 4) maintenance of patient in semi-recumbent position to improve chest physiotherapy in intubated patients. Specific measures for UTI prevention include: 1) use of a catheter-valve instead of a standard drainage system; 2) use of a silver-alloy, hydro gel-coated latex urinary catheter instead of uncoated catheters. Biofilm represents a new variable: the capacity of bacteria to organize a biofilm on a device surface can explain the difficulty in preventing and eradicating an infection in a critically ill patient. More clinical trials are needed to verify the efficacy of prevention measures of ICU infections.
Section of Anesthesiology and Intensive Care, Department of Critical Care, University of Florence, Florence, Italy.
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Di Filippo
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De Gaudio
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018441:Biofilms; D002986:Clinical Trials as Topic; D016638:Critical Illness; D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control; D004866:Equipment Contamination; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods*; D007362:Intensive Care Units; D008297:Male; D018410:Pneumonia, Bacterial / Q000209:etiology / Q000517:prevention & control*; D011322:Primary Prevention / Q000379:methods; D011379:Prognosis; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000295:instrumentation; D018570:Risk Assessment; D014546:Urinary Catheterization / Q000009:adverse effects* / Q000295:instrumentation; D014552:Urinary Tract Infections / Q000209:etiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents