In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography.
An ultrahigh-speed spectral domain optical coherence tomography (SD-OCT) system is presented that achieves acquisition rates of 29,300 depth profiles/s. The sensitivity of SD-OCT and time domain OCT (TD-OCT) are experimentally compared, demonstrating a 21.7-dB improvement of SD-OCT over TD-OCT. In vivo images of the human retina are presented, demonstrating the ability to acquire high-quality structural images with an axial resolution of 6 microm at ultrahigh speed and with an ocular exposure level of less than 600 microW.
Nassif
Nader
N
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA.
Cense
Barry
B
Park
B Hyle
BH
Yun
Seok H
SH
Chen
Teresa C
TC
Bouma
Brett E
BE
Tearney
Guillermo J
GJ
de Boer
Johannes F
JF
D006801:Humans; D008962:Models, Theoretical; D012160:Retina / Q000033:anatomy & histology*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods