A new aristolactam alkaloid and anti-platelet aggregation constituents from Piper taiwanense.
A new alkaloid, piperolactam E, and fourteen known compounds have been isolated from the stem of Piper taiwanense. Bioassay-guided fractionation of the methanolic extract led to the isolation, from the chloroform-soluble part, of 4-allylcatechol, eugenol, trans-caffeic aldehyde, 2-hydroxy-1-methoxy-4 H-dibenzo[ de,g]quinoline-4,5-(6 H)-dione, piperolactam B, piperolactam C, and piperolactam E as the active principles of anti-platelet aggregation in vitro. The derived 1,2-diacetoxy-4-allyl-benzene and eugenol acetate exhibit stronger anti-platelet aggregation activities induced by arachidonic acid than 4-allylcatechol and eugenol, respectively.
Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
Yu-Chang
YC
Chen
Jih-Jung
JJ
Chen
Ya-Ling
YL
Chang
Che-Ming
CM
Teng
Wei-Yu
WY
Lin
Chin-Chung
CC
Wu
Ih-Sheng
IS
Chen
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D034341:Aristolochic Acids / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits
D000470:Alkaloids; D034341:Aristolochic Acids; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors