[In vitro study on the cytotoxicity of strontium substituted hydroxyapatite].
OBJECTIVE
To evaluate the cytotoxicity of strontium substituted hydroxyapatite.


METHODS
Cell Relative Growth Rate(RGR) method, MTT assay and Flow Cytometry(FCM) method were used, and the strontium substituted hydroxyapatite contained different strontium concentration(0%,1%,5%,10%,100%).


RESULTS
It was found that there's no apparent cytotoxicity of all the strontium substituted hydroxyapatite,but the cytotoxicity increased as the strontium concentration raised. As the FCM method appeared, there was no apparent difference between the pure hydroxyapatite and 1%,5% strontium substituted hydroxyapatite.


CONCLUSIONS
Strontium substituted hydroxyapatite has good biocompatibility, and 10%,100% strontium substituted hydroxyapatite has weak cytotoxicity.
Fu
Yuan-fei
YF
Department of Prosthodontics, Ninth People's Hospital, Shanghai Second Medical University 200011, Shanghai, China.
Chen
De-min
DM
Zhang
Jian-zhong
JZ