Mice transgenic for human TTR have the same frequency of renal TTR deposition whether maintained in conventional or specific pathogen free environments.
Mice transgenic for many copies of the human wild type transthyretin gene were bred and maintained in a specific pathogen free environment until twelve months of age. At that time, half the animals were moved to a conventional animal facility. The incidence of both transthyretin and AA amyloid was the same in both groups at two years of age, indicating that in this model, the frequency, extent or nature of TTR-amyloid deposition did not differ significantly between conventional and specific pathogen-free environments.
New York University, Departments of Medicine & Pathology, 550 First Avenue, New York, NY 10016, USA.
Clement E
CE
Tagoe
Daniel R
DR
Jacobson
Gloria
G
Gallo
Joel N
JN
Buxbaum
D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D004777:Environment; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D007674:Kidney Diseases / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008822:Mice, Transgenic; D011228:Prealbumin / Q000235:genetics / Q000502:physiology*; D013047:Specific Pathogen-Free Organisms
D000682:Amyloid; D011228:Prealbumin