[Evaluation of TGF-beta1 expressed by oral and maxillofacial malignant neoplasm].
OBJECTIVE
To investigate the relationship between the level of transforming growth factor beta I(TGF-beta(1)) in oral and maxillofacial malignant neoplasms and the biological characteristics of these carcinoma cells.


METHODS
The level of TGF-beta(1) in the carcinoma tissue cells, human tongue squamous cell carcinoma cell line Tca8113, human minor salivary gland carcinoma cell line ACC-2 and highly metastatic adenoid cystocarcinoma cell line ACC-M was measured by ELISA KIT.


RESULTS
The level of TGF-beta(1) in the carcinoma tissue cells had significant difference to that of normal cells(P<0.01). The level in Tca8113 and ACC-2 cells was significantly higher(P<0.05). Squamous cell carcinoma cell line Tca8113 had the same level of TGF-beta(1) as the adenoid cystocarcinoma cell line ACC-2, but the highly metastatic adenoid cystocarcinoma cells(ACC-M) expressed far less compared to ACC-2 cells (P<0.01). The level of TGF-beta(1) secreted by ACC-M cells to the culture without serum was also lower than that of any of the other carcinoma cells or normal cells.


CONCLUSIONS
The level of TGF-beta(1) expression had significant relation to the proliferation, invasion and metastasis of oral and maxillofacial malignant neoplasms.
Li
Qing
Q
Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Zhou
Xiao-jian
XJ
Zhang
Zhi-yuan
ZY
Patima
Chen
Wan-tao
WT