Reappraisal of the regulation of lactococcal L-lactate dehydrogenase.
Lactococcal lactate dehydrogenases (LDHs) are coregulated at the substrate level by at least two mechanisms: the fructose-1,6-biphosphate/phosphate ratio and the NADH/NAD ratio. Among the Lactococcus lactis species, there are strains that are predominantly regulated by the first mechanism (e.g., strain 65.1) or by the second mechanism (e.g., strain NCDO 2118). A more complete model of the kinetics of the regulation of lactococcal LDH is discussed.
van Niel
Ed W J
EW
Department of Applied Microbiology, Lund University, Lund SE-221 00, Sweden. ed.van_niel@tmb.lth.se
Palmfeldt
Johan
J
Martin
Rani
R
Paese
Marco
M
Hahn-Hägerdal
Bärbel
B
D005635:Fructosediphosphates / Q000378:metabolism; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000145:classification / Q000378:metabolism*; D013294:Lactococcus lactis / Q000145:classification / Q000201:enzymology*; D008954:Models, Biological; D009243:NAD / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D013045:Species Specificity; D013379:Substrate Specificity
D005635:Fructosediphosphates; D010710:Phosphates; D009243:NAD; D007770:L-Lactate Dehydrogenase; C029063:fructose-1,6-diphosphate