Cloning of rat lymphocyte activation gene-3 (Lag3; CD223) cDNA and its mRNA expression in rat tissues.
Rat lymphocyte activation gene-3 (Lag3; CD223) cDNA contains an open reading frame (1575 bp) encoding 525 amino acids. Rat Lag3 mRNA transcript was detected as a single species of approximately 2 kb from phytohemagglutinin (PHA)-stimulated lymphocytes. Further analysis revealed that rat Lag3 mRNA was mainly expressed in lymphoid tissues.
Department of Microbiology and Immunology, School of Medicine, Hanyang University, Seoul, South Korea.
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D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D015152:Blotting, Northern; D003001:Cloning, Molecular; D003545:Cysteine / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D015536:Down-Regulation; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010835:Phytohemagglutinins / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D013154:Spleen / Q000166:cytology; D014018:Tissue Distribution; D000093322:Lymphocyte Activation Gene 3 Protein
D015703:Antigens, CD; D018076:DNA, Complementary; D010835:Phytohemagglutinins; D012333:RNA, Messenger; D003545:Cysteine; D000093322:Lymphocyte Activation Gene 3 Protein