Evaluation of metallothionein and p53 expression as potential prognostic markers for laryngeal squamous cell carcinoma.
The aim of the study was to determine the contribution of metallothionein (MT) and p53 expression in predicting laryngeal squamous cell carcinoma (SCC) recurrence. This was a retrospective study in which MT and p53 immunopositive staining in 32 laryngeal SCC paraffin-embedded sections, were correlated with clinical recurrence. Recurrence was observed in 8 cases with MT expression (42.1%) and 1 case with no expression (7.7%). Moderate and strong MT expression was associated with 14.3% and 58.3% recurrence, respectively. Recurrence was similar for both p53-negative (21.1%) and p53-positive (27.3%) groups. One third of the patients expressing both p53 and MT simultaneously had recurrence. Thus, the combined expression of p53 and MT did not improve the predictive value for recurrence compared to MT alone. MT over-expression may be an independent risk factor for laryngeal SCC recurrence.
Department of Otolaryngology, Charles R. Drew University of Medicine & Science, 1731 East 120th Street, Hawkins Building, Room 3067, Los Angeles, CA 90059, USA.
J J
JJ
Brown
H
H
Xu
L
L
William-Smith
H
H
Mohamed
S
S
Teklehaimanot
J
J
Zhuo
R
R
Osborne
F
F
Liu
R E
RE
Gowans
J
J
Nishitani
X
X
Liu
D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000276:immunology / Q000378:metabolism*
D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; D008668:Metallothionein