Tumor necrosis factor alpha gene polymorphism is associated with cerebral infarction.
We examined whether promoter region polymorphism in the tumor necrosis factor-alpha (TNFalpha) gene at position -308 affects the odds of cerebral infarction (CI). We genotyped 366 CI patients and 610 healthy controls for the same polymorphism. A significant decrease was found for the TNFalpha A allele in CI patients compared with controls (P=0.003). Our finding suggests that TNFalpha promoter region polymorphism is responsible for susceptibility to CI in Koreans.
Um
Jae-Young
JY
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, 1 Hoigi-Dong, Dongdaemun-Gu, Seoul 130-701, South Korea.
Kim
Hyung-Min
HM
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha