Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers.
This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-beta-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with commercial tablets. Administration of macrogol suppositories did not result in measurable plasma concentrations of albendazole sulfoxide.
Rigter
I M
IM
Department of Clinical Pharmacy, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Schipper
H G
HG
Koopmans
R P
RP
van Kan
H J M
HJ
Frijlink
H W
HW
Kager
P A
PA
Guchelaar
H-J
HJ
D000293:Adolescent; D000328:Adult; D015766:Albendazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000871:Anthelmintics / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000871:Anthelmintics; D013607:Tablets; D015766:Albendazole