Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units.
OBJECTIVE
To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.


METHODS
Prospective observational study.


METHODS
Medical intensive care unit at a university hospital.


METHODS
Fourteen patients hospitalised in a medical intensive care unit.


METHODS
Cystatin C and creatinine plasmatic levels were measured in 40 blood samples taken with an interval of at least 24 h.


RESULTS
Glomerular filtration rate was estimated by creatinine clearance using 24-h urine collection and the classical Cockcroft-Gault equation. The ability of cystatin C to detect a glomerular filtration rate under 80 ml/min per 1.73 m(2) was significantly better than that of creatinine ( p<0.05).


CONCLUSIONS
Cystatin C, a new plasmatic marker of renal function, could be used to detect renal failure in intensive care in the future.
Nephrology, Department of Medicine, Liege University Hospital, CHU Sart Tilman (B35), 4000 Liege, Belgium.
Pierre
P
Delanaye
Bernard
B
Lambermont
Jean-Paul
JP
Chapelle
Jacques
J
Gielen
Paul
P
Gerard
Georges
G
Rorive
D003404:Creatinine / Q000097:blood*; D003422:Critical Care; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012372:ROC Curve
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine