RNA ligase; picking up the pieces.
In the current issue of Structure, Ho and coworkers report the crystal structure and mechanism of a T4 RNA ligase. These studies provide valuable insights on the mechanism and origin of RNA and DNA ligases, and RNA capping enzymes.
Wood
Zachary A
ZA
Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA.
Sabatini
Robert S
RS
Hajduk
Stephen L
SL
D000255:Adenosine Triphosphate / Q000378:metabolism; D018360:Crystallography, X-Ray; D011088:DNA Ligases / Q000737:chemistry / Q000378:metabolism; D004260:DNA Repair; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D012315:RNA Caps / Q000378:metabolism; D011130:RNA Ligase (ATP) / Q000737:chemistry / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*
D012315:RNA Caps; D014764:Viral Proteins; D000255:Adenosine Triphosphate; D011088:DNA Ligases; D011130:RNA Ligase (ATP); C467724:bacteriophage T4 RNA ligase 2