Circulating vascular endothelial growth factor concentrations in a case of pulmonary hypertrophic osteoarthropathy. Correlation with disease activity.
Vascular endothelial growth factor (VEGF) is a cytokine overexpressed in hypoxic and malignant pathologies. VEGF induces vascular hyperplasia, new bone formation, and edema. These histological abnormalities characterize hypertrophic osteoarthropathy. We describe a case of pulmonary hypertrophic osteoarthropathy with high circulating VEGF levels. Removal of the lung tumor led to a dramatic disappearance of the skeletal abnormalities and to reduction of circulating VEGF levels. Histochemical studies of the excised tumor confirmed abnormal VEGF production.
Olán
Francisco
F
National Institute of Cardiology and National Institute of Respiratory Diseases, Mexico City, Mexico.
Portela
Margarita
M
Navarro
Carmen
C
Gaxiola
Miguel
M
Silveira
Luis H
LH
Ruiz
Victor
V
Martínez-Lavín
Manuel
M
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000378:metabolism; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000097:blood / Q000209:etiology* / Q000378:metabolism; D012720:Severity of Illness Index; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000097:blood*
D042461:Vascular Endothelial Growth Factor A