Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.
A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal profile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus.
Department of Chemistry, Lucknow University, Lucknow-226001, U. P., India. vishnutandon@rediffmail.com
Vishnu K
VK
Tandon
Rakeshwar B
RB
Chhor
Ravindra V
RV
Singh
Sanjay
S
Rai
Dharmendra B
DB
Yadav
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002279:Carcinoma 256, Walker; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009285:Naphthoquinones; C035342:1,4-naphthoquinone