A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A.
A patented aqueous extract from North American ginseng (Panax quinquefolium), containing mainly oligosaccharides and polysaccharides, is commercially available over the counter as COLD-FX (CVT-E002). This proprietary extract is used for the treatment of upper respiratory tract infections. Its in vitro stimulating effects on the immunoglobulin production by B lymphocytes and on natural immune responses by peritoneal exudates macrophages have been previously reported. Using C57 BL/6 mice, an ex vivo study was conducted to examine Con-A-induced splenocytic productions of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) as markers of acquired immune responses. CVT-E002 (10-500 microg/ml) significantly increased Con-A-induced IL-2 and IFN-gamma productions in spleen cells in a dose-dependent manner. Such response was seen by the ginseng extract originated from three different lots, suggesting consistency between the lots.
CV Technologies Inc, Edmonton Research Park, Edmonton, AB, Canada T6N 1E5.
Meiqi
M
Wang
Larry J
LJ
Guilbert
Jie
J
Li
Yingqi
Y
Wu
Peter
P
Pang
Tapan K
TK
Basu
Jacqueline J
JJ
Shan
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D002626:Chemistry, Pharmaceutical; D003208:Concanavalin A; D004305:Dose-Response Relationship, Drug; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D005894:Panax; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D015203:Reproducibility of Results; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D010936:Plant Extracts; D003208:Concanavalin A; D007371:Interferon-gamma