In vitro activities of new quinolones and oxazolidinones against Actinomadura madurae.
In this work, we studied the in vitro sensitivity of 24 strains of Actinomadura madurae to a new oxazolidinone (DA-7867), gatifloxacin, moxifloxacin, and garenoxacin by using a broth microdilution method. We observed that the A. madurae strains had a high level of sensitivity to all the antimicrobials tested. The most active drug was DA-7867, with a MIC at which 90% of the strains are inhibited (MIC(90)) of 0.125 micro g/ml and a MIC(50) of 0.06 micro g/ml.
Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Nuevo León, México. luvera_99@yahoo.com
Lucio
L
Vera-Cabrera
Elsa Y
EY
Ochoa-Felix
Gloria
G
Gonzalez
Rolando
R
Tijerina
Sung H
SH
Choi
Oliverio
O
Welsh
D000890:Anti-Infective Agents / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology*; D012874:Skin Diseases, Infectious / Q000382:microbiology
D000890:Anti-Infective Agents; D023303:Oxazolidinones; D015363:Quinolones