[Study on the clinical value of serum cardiac troponin T in early diagnosing of acute non-Q-wave myocardial infarction and prognostic evaluation].
OBJECTIVE
To investigate the value of serum cardiac troponin T (cTnT) in diagnosing earlier acute non-Q-wave myocardial infarction (NQMI) and judging the prognosis.


METHODS
Seventy-four NQMI patients and 118 Q-wave myocardial infarction (QMI) patients were studied. Serum cTnT and MB isoenzyme of creatine kinase (CK-MB) levels were monitored on fixed time. On the 15th day of hospitalization, 99 mTc-MIBI myocardial single photon emission computed tomography (SPECT) was performed to assess the infarct size index. Clinical informations of the two groups such as cardiac dysfunction, re-infarction, fatal cadiac arrhythmia, sudden death were collected.


RESULTS
The time for serum cTnT beginning to rise was earlier than CK-MB. Its peak time value was paralled to that of CK-MB, and cTnT elevation lasted longer than CK-MB. Serum cTnT and CK-MB peak value showed positive correlation with the infarct size index (both P<0.01). The peak values of cTnT and CK-MB in NQMI group were lower than those in QMI group, and the infarct size was smaller than QMI group (all P<0.05). The frequencies of cardiac events were significantly raised in both groups when there was a high level of serum cTnT. But the proportion in NQMI group was less than those in QMI group (P<0.05). The cardiac events in NQMI group were less than that in QMI group (P<0.05).


CONCLUSIONS
Serum cTnT is an effective marker for diagnosing earlier NQMI, detecting myocardial damage, estimating infarct size and prognosis in the nearly future.
Zheng
Qun
Q
Department of Cardiology, Harrison International Peace Hospital, Hengshui 053000, Hebei, China.
Wang
Wei-zhan
WZ
Zhang
Ying-xuan
YX
Wang
Lan
L
Zhao
Ling-jun
LJ
D000368:Aged; D003402:Creatine Kinase / Q000032:analysis; D052279:Creatine Kinase, MB Form; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011379:Prognosis; D013997:Time Factors; D020107:Troponin T / Q000097:blood*
D007527:Isoenzymes; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form