[Effect of perftoran on cerebral blood flow in the reperfusion period after global transient brain ischemia].
It was established, while modeling the global transient cerebral ischemia in experiments with 51 anesthetized nonlinear white rats (weight 300-330 g), that a preliminary administration of perftoran in the discussed pathology does not only improve the reperfusion process in the brain but also levels the deficits of crystalloid solutions used as blood substitutes (by the example of physiological solution). Therefore, the drug has a cytoprotective action on the vascular-system endothelium. A direct admixture of perftoran to the autoblood introduced after global transient cerebral ischemia improves essentially the reperfusion-period course in the brain versus the combination of physiological solution and autoblood.
Aleksandrin
V V
VV
Kozhura
V L
VL
Novoderzhkina
I S
IS
Moroz
V V
VV
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004195:Disease Models, Animal; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D007275:Injections, Intravenous; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D017078:Laser-Doppler Flowmetry; D008297:Male; D051381:Rats; D015427:Reperfusion Injury / Q000517:prevention & control*
D005466:Fluorocarbons; C063334:perftoran