[The clinical evaluation of tinidazole-iodoform-phenocamphor paste as an intra-canal sterilization medication for acute periapical periodontitis].
OBJECTIVE
To compare the clinical effect of tinidazole-iodoform-phenocamphor paste on acute periapical periodontitis with of formocresol.


METHODS
80 permanent teeth of acute periapical periodontitis were selected and divided randomly into tinidazole-iodoform-phenocamphor paste group (T group) and formocresol group (C group). The periapical signs and symptoms were recorded. Radiographs were taken and periapical radiolucent areas were calculated. After root canal preparation,the tinidazole-iodoform-phenocamphor paste was used as an intra-canal dressing medication for 7 days in T group and the formocresol paper point was used in C group. During the course of root canal treatment,the standard paper-point sampling method was used to collect and quantify the periapical exudates and the clinical findings were assessed with clinical periapical index(CPI). All statistical analyses were finished with Sigmastat software.


RESULTS
At the first visit, there was no significant difference between two groups of CPI indexes and exudates volumes (P>0.05). The stepwise regression results suggested that exudates volumes had a significant correlation to periapical percussion(P=0.0031). There was a close relationship between radiolucent areas and periapical percussion or swelling degree (P=0.1148, P<0.0001). After the root canal sterilization, there was a statistically significant decrease in exudates volumes and CPI indexes (P<0.01), but the difference of exudates volumes and CPI indexes between two groups was not statistically significant (P>0.05).


CONCLUSIONS
It indicated that tinidazole-iodoform-phenocamphor paste had the same effect on controlling acute periapical periodontitis as that of formocresol.
The Stomatology School of Nanjing Medical University, Nanjing 210029, China. yuziyi-yjh@263.net.cn
Jin-hua
JH
Yu
Wei-yi
WY
Yu
Wei-hong
WH
Liu
Ying
Y
Ye