Integrating sensory and motor mapping in a comprehensive MEG protocol: clinical validity and replicability.
Considerable evidence supports the idea of magnetoencephalography (MEG) being a valuable noninvasive tool for presurgical mapping of sensory and motor functions. In this study, we test the validity and replicability of a new experimental paradigm for simultaneous sensory and motor mapping using MEG recordings. This comprehensive sensorimotor protocol (CSSMP), where external mechanic stimulation serves as a cue for voluntary movements, allows the recording of sensory and motor cortical responses during a single activation task. The stability and replicability of MEG-derived recordings during this paradigm were tested in a group of eight neurologically normal volunteers and six patients with perirolandic lesions. We found that a common sensorimotor cortical network, engaging sensory (S1, S2) and motor (M1) areas, was reliably activated in all subjects and patients and that the results remained exceptionally stable over time. Additionally, the clinical validity of the MEG-derived maps of activation was tested through intraoperative electrocortical stimulation mapping in the group of patients. The MEG-derived anatomical maps for specific sensory (S1) and motor (M1) responses were verified, by direct cortical mapping, and confirmed with the patient's surgical outcome. The results of this validation study show that the so-called CSSMP is a reliable and reproducible method for assessing simultaneously sensory and motor areas. This method minimizes methodological problems and improves our knowledge of the spatiotemporal organization of the sensorimotor cortical network and helps to optimize the surgical management of patients with perirolandic lesions.
Castillo
Eduardo M
EM
Vivian L. Smith Center for Neurologic Research, Department of Neurosurgery, University of Texas-Houston Medical School, Houston, TX 77030, USA. eduardo.m.castillo@uth.tmc.edu
Simos
Panagiotis G
PG
Wheless
James W
JW
Baumgartner
James E
JE
Breier
Joshua I
JI
Billingsley
Rebecca L
RL
Sarkari
Shirin
S
Fitzgerald
Michele E
ME
Papanicolaou
Andrew C
AC
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery; D005071:Evoked Potentials / Q000502:physiology; D019054:Evoked Potentials, Motor / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009044:Motor Cortex / Q000502:physiology*; D019635:Neurosurgical Procedures; D010812:Physical Stimulation; D015203:Reproducibility of Results; D013003:Somatosensory Cortex / Q000502:physiology*; D016896:Treatment Outcome