Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult.
Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase.
Program for Collaborative Research in Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. dkim@curxcel@com
Darrick S H L
DS
Kim
Jin Yung
JY
Kim
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D002396:Catechols / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000494:pharmacology; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D016229:Amyloid beta-Peptides; D002396:Catechols; D018696:Neuroprotective Agents; D010936:Plant Extracts; C040115:shogaol