Establishing equivalence for activity standards of short-lived radionuclides using the NPL secondary standard radionuclide calibrator.
Conventional comparison techniques used between National Metrology Institutes are not practicable for short-lived radionuclides because of geographical separations and transport difficulties. The NPL Secondary Standard Radionuclide Calibrator provides an alternative approach and a comparison was conducted with 18F to investigate its feasibility. The exercise was successful and the paper details the protocol used, the quality assurance mechanisms introduced to underpin the comparison and an analysis of the results. It was also demonstrated that this approach could be linked to the BIPM SIR system. Recommendations are presented for the extension of this work to other suitable, short-lived radionuclides.
Ionising Radiation Metrology Consultants Ltd, 152 Broom Road, Teddington, Middlesex TW11 9PQ, UK. mike.woods@blueyonder.co.uk
M J
MJ
Woods
M
M
Baker
D002138:Calibration / Q000592:standards; D005462:Fluorine Radioisotopes / Q000032:analysis / Q000592:standards; D007391:International Cooperation; D011785:Quality Assurance, Health Care / Q000379:methods / Q000592:standards; D011786:Quality Control; D011868:Radioisotopes / Q000032:analysis* / Q000592:standards*; D011874:Radiometry / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000592:standards*; D012015:Reference Standards; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013048:Specimen Handling / Q000379:methods* / Q000592:standards; D014055:Tomography, Emission-Computed / Q000592:standards
D005462:Fluorine Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals