Quantitative analysis of a parasitic antiviral strategy.
We extended a computer simulation of viral intracellular growth to study a parasitic antiviral strategy that diverts the viral replicase toward parasite growth. This strategy inhibited virus growth over a wide range of conditions, while minimizing host cell perturbations. Such parasitic strategies may inhibit the development of drug-resistant virus strains.
Kim
Hwijin
H
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706-1607, USA.
Yin
John
J
D017908:Allolevivirus / Q000235:genetics / Q000254:growth & development; D000998:Antiviral Agents / Q000494:pharmacology*; D036022:Capsid Proteins / Q000096:biosynthesis; D003198:Computer Simulation; D024882:Drug Resistance, Viral / Q000235:genetics*; D004926:Escherichia coli / Q000821:virology; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects; D014780:Viruses / Q000187:drug effects* / Q000201:enzymology
D000998:Antiviral Agents; D036022:Capsid Proteins; D012367:RNA, Viral