Breast cancer biomarkers and molecular medicine: part II.
In this second part of the two-part review of breast cancer biomarkers and molecular medicine, the first section will consider additional breast cancer prognostic factors, including oncogenes, tumor suppressor genes, cell adhesion molecules, invasion-associated proteins and proteases, hormone receptor proteins, drug resistance proteins, apoptosis regulators, transcription factors, telomerase, DNA repair and methylation and transcriptional profiling using high-density genomic microarrays. The second section will consider the prediction of therapy response using the techniques of pharmacogenetics and pharmacogenomics.
Department of Pathology and Laboratory Medicine, MC 80 Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. rossj@mail.amc.edu
Jeffrey S
JS
Ross
Gerald P
GP
Linette
James
J
Stec
Edwin
E
Clark
Mark
M
Ayers
Nick
N
Leschly
W Fraser
WF
Symmans
Gabriel N
GN
Hortobagyi
Lajos
L
Pusztai
D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D018432:Drug Resistance, Multiple; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D006801:Humans; D009857:Oncogenes; D010597:Pharmacogenetics; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D019253:Proto-Oncogene Proteins c-bcl-2; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014157:Transcription Factors; D004247:DNA; D019098:Telomerase; D010450:Endopeptidases