Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus.
Catharanthus roseus cell suspension cultures were used to bioconvert both triptolide (1) and triptonide (2). The same reaction path was followed in both biotransformations. Two biotransformed products were obtained and their structures identified as triptriolide (3) and 12beta,13alpha-dihydroxytriptonide (4), respectively, from 1 and 2. Product 4 is a new compound.
Ning
Li-Li
LL
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China.
Han
Jian
J
Zhang
Xing-Yi
XY
Guo
Hong-Zhu
HZ
Bi
Kai-Shun
KS
Guo
De-An
DA
D001711:Biotransformation; D030008:Catharanthus / Q000166:cytology / Q000378:metabolism*; D002478:Cells, Cultured; D004224:Diterpenes / Q000493:pharmacokinetics*; D004852:Epoxy Compounds; D010616:Phenanthrenes / Q000493:pharmacokinetics*; D014315:Triterpenes / Q000493:pharmacokinetics*
D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; D014315:Triterpenes; C001899:triptolide; C084079:triptonide