Membranous nephropathy after allogeneic stem cell transplantation: report of 2 cases.
Nephrotic syndrome (NS) is a rare complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The cases of 2 patients who developed NS after receiving allo-HSCT for chronic myelogenous leukemia and acute lymphoblastic leukemia are described. In both cases, renal biopsy revealed membranous nephropathy (MN), and the patients achieved remission after treatment with prednisolone. Previously reported cases and our experience suggest that most NS patients show MN in histologic tests after allo-HSCT and that its development is related to graft-versus-host disease. Early treatment with steroids seems effective for resolving symptoms of NS and improving renal function.
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biosciences, Nagasaki, Japan. chizuko@net.nagasaki-u.ac.jp
Chizuko
C
Tsutsumi
Yasushi
Y
Miyazaki
Takuya
T
Fukushima
Shinichiro
S
Yoshida
Jun
J
Taguchi
Chie
C
Miyake
Masanobu
M
Miyazaki
Shigeru
S
Kohno
Itsuro
I
Jinnai
Masao
M
Tomonaga
D000293:Adolescent; D015433:Glomerulonephritis, Membranous / Q000209:etiology* / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014184:Transplantation, Homologous