Effects of simulated microgravity conditions on carrageenin-induced oedema in rat.
The effects of simulated microgravity conditions, using a three-dimensional clinostat (Random Positioning Machine, RPM), on carrageenin-induced paw oedema in rats as a model of local inflammation were evaluated. RPM-exposed animals showed a significant reduction of oedema and a more pronounced decrease in body weight with respect to control groups. Moreover, aspirin (ASA) treatment, an anti-inflammatory agent, on RPM-exposed rats did not exhibit any activity after carrageenin challenge with respect to RPM control animals on the ground. ASA activity on RPM could be prevented by RPM-induced anti-oedematous effect. RPM-induced anti-oedematous effect did not reversed by pre-treatment with the non-selective glucocorticoid receptor antagonist, mifepristone ruling out the supposed influence of an of cortisol release during the RPM treatment.
Dipartimento di Scienze del Farmaco, University of Sassari, via Muroni, Italy. apeana@ssmain.uniss.it
A T
AT
Peana
M L
ML
Chessa
M
M
Deligios
C F
CF
Cesarone
M A
MA
Meloni
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P
Pippia