Ribosomal mutations in Arcanobacterium pyogenes confer a unique spectrum of macrolide resistance.
Four macrolide-resistant Arcanobacterium pyogenes isolates contained A2058T, A2058G, or C2611G (Escherichia coli numbering) mutations in their 23S rRNA genes. While these mutations conferred resistance to erythromycin, oleandomycin, and spiramycin, they did not confer resistance to tylosin.
Jost
B Helen
BH
Department of Veterinary Science and Microbiology, The University of Arizona, Tucson, Arizona 85721, USA. jost@u.arizona.edu
Trinh
Hien T
HT
Songer
J Glenn
JG
Billington
Stephen J
SJ
D000191:Actinomycetaceae / Q000187:drug effects* / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation / Q000502:physiology*; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D012270:Ribosomes / Q000187:drug effects / Q000235:genetics*
D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S