[Anti-p53 antibodies as markers of carcinogenesis in exposures to vinyl chloride].
The aim of the study was to estimate the possible use of plasma anti-p53 antibodies as marker premature of cancerogenesis. The study carried on 167 male subject exposed to vinyl chloride (CV) (cumulative concentration ranged from 4 to 2823 ppm) tested anti-p53 positive in 5 cases (3.9%), all distributed in the high exposure group (> 1000 ppm); No subject in the control group tested positive. There was a significant association. between cumulative VC exposure concentration (P < 0.002) and positive anti-p53 expression. In summary, the study support a significant relationship between plasma anti-p53 and VC only for heavy exposure. The authors assume the existence of a threshold limit to the effectiveness.
Mocci
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Istituto di Medicina Legale e di Medicina del Lavoro, Università di Sassari.
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D000328:Adult; D000368:Aged; D000906:Antibodies / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D002273:Carcinogens / Q000633:toxicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000139:chemically induced*; D009784:Occupational Diseases / Q000097:blood* / Q000139:chemically induced*; D016159:Tumor Suppressor Protein p53 / Q000276:immunology*; D014752:Vinyl Chloride / Q000633:toxicity*
D000906:Antibodies; D014408:Biomarkers, Tumor; D002273:Carcinogens; D016159:Tumor Suppressor Protein p53; D014752:Vinyl Chloride