International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor.
Oxoeicosanoids are a family of biologically active arachidonic acid derivatives that have been intimately linked with cellular migration. These metabolites are not only potent chemotaxins but also elicit oxygen radical production as well as induce secretory events in different cells. The most potent native ligand reported is 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), and the cell membrane receptor activated has now been cloned. This receptor is distinct from those receptors activated by either the prostaglandins or the leukotrienes. The purpose of this review is to briefly summarize the molecular evidence and highlight the significance of this receptor. In addition, an official nomenclature for this oxoeicosanoid receptor is proposed.
Centre National de la Recherche Scientifique UMR 7131, Hôpital Broussais, Bâtiment Les Mariniers, Paris, France. charlesbrink@hotmail.com
Charles
C
Brink
Sven-Erik
SE
Dahlén
Jeffrey
J
Drazen
Jilly F
JF
Evans
Douglas W P
DW
Hay
G Enrico
GE
Rovati
Charles N
CN
Serhan
Takao
T
Shimizu
Takehiko
T
Yokomizo
D000595:Amino Acid Sequence; D000818:Animals; D001095:Arachidonic Acids / Q000145:classification / Q000235:genetics / Q000378:metabolism; D015777:Eicosanoids / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D018055:Receptors, Eicosanoid / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D009626:Terminology as Topic
D001095:Arachidonic Acids; D015777:Eicosanoids; D018055:Receptors, Eicosanoid