Association of FAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease.
OBJECTIVE
To investigate the association of FAS gene polymorphism with coeliac disease (CD) development.


METHODS
FAS-G670A gene polymorphism, located in a gamma interferon activation site, was studied in 146 unrelated CD patients and 203 healthy ethnically matched controls. The restriction fragment length polymorphism (RFLP) method was used to identify FAS-G670A gene polymorphism.


RESULTS
No significant difference was found in genotype frequency between CD cases and controls. In controls, however, the frequency of the GG genotype was significantly higher in women (26.5%) than in men (12.8%) (OR= 2.44, 95% CI 1.15-5.20, P=0.020) and it was also higher in men with CD than controls (OR=2.60, 95% CI 0.96-7.05, P=0.061). The GG genotype frequency was significantly higher in patients with most severe villous atrophy (Marsh IIIc lesions) (OR=3.74, 95% CI 1.19-11.82, P=0.025). A significantly less proportion of men suffered from Marsh IIIc lesions than women (OR=0.20, 95% CI 0.06-0.68, P=0.01). The risk of having severe villous atrophy increased with the additive effect of the G allele in women (P=0.027 for trend, age and gender adjusted).


CONCLUSIONS
FAS-G670A gene polymorphism is associated with the severity of villous atrophy in CD. Female gender is also associated with the severity of villous atrophy.
VU University Medical Centre, Department of Gastroenterology, Laboratory of Immunogenetics, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.
Jing
J
Wu
B Z
BZ
Alizadeh
T V
TV
Veen
J W R
JW
Meijer
C J J
CJ
Mulder
A S
AS
Pena
D001284:Atrophy; D002446:Celiac Disease / Q000235:genetics* / Q000473:pathology*; D015331:Cohort Studies; D020895:Enterocytes / Q000473:pathology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index; D012737:Sex Factors; D019014:fas Receptor / Q000235:genetics*
D019014:fas Receptor