Synthesis of aryl ketones by the PD-catalyzed C-H activation of arenes and intermolecular carbopalladation of nitriles.
The palladium-catalyzed reaction of simple arenes and nitriles provides good to excellent yields of aryl ketones or the corresponding hindered imines. The addition of a small amount of DMSO increases the yields dramatically. Both intermolecular and intramolecular examples of this process are successful. This novel chemistry is believed to involve palladium-catalyzed C-H activation, followed by carbopalladation of the nitrile.
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
Chengxiang
C
Zhou
Richard C
RC
Larock