Study of the analgesic efficacy of Dexketoprofen Trometamol 25mg. vs. Ibuprofen 600mg. after their administration in patients subjected to oral surgery.
OBJECTIVE
Compare the analgesic efficacy of two nonsteroidal anti-inflammatory drugs (NSAIDs) belonging to the family of propionic acids after oral surgery in order to assess which one is most effective with the minimum side effects and lowest dose. Normally, the pain after oral surgery is considered as moderate-intense and NSAIDs are the first choice when treating post-surgical dental pain. As we know, the great problem of these drugs is found in their undesirable effects. The enantiomer-S(+) component is known to be related with analgesia and need for lower dose of these drugs.


METHODS
The patients are given questionnaires with pain assessment tables and different observations are made: postsurgical pain, pain in the first hour after administration of the analgesic, inflammation, bleeding, hematoma, etc. We assess the effect of the different drugs used in the study based on the efficacy-time coordinates as well as the anti-inflammatory effect and their side effects.


RESULTS
It is verified that there is moderate pain after oral surgery and the drugs used are effective in the doses and intervals indicated. During the first hour after taking the analgesic, those patients treated with Dexketoprofen Trometamol (DKT) presented less pain compared to those who were treated with Ibuprofen (IBU). It is verified that there is inflammation in most of the interventions, the extractions of the semi-impacted third molars (SITM) present greater bleeding on the first day and the extractions of impacted third molars (ITM) present more bleeding on the third day. These last two interventions (ITM) also present hematoma.


CONCLUSIONS
We demonstrate the greater analgesic efficacy of Dexketoprofen Trometamol in the first hour after the oral surgical intervention and its greater anti-inflammatory effect.
Jiménez-Martínez
Esther
E
Servicio de Estomatología, Fundación Jiménez Díaz, Madrid, Spain.
Gasco-García
Carmen
C
Arrieta-Blanco
Juan José
JJ
Gomez del Torno
Javier
J
Bartolome Villar
Begoña
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D007660:Ketoprofen / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000009:adverse effects*; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D011795:Surveys and Questionnaires; D014325:Tromethamine / Q000008:administration & dosage* / Q000031:analogs & derivatives*
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; C118296:dexketoprofen trometamol; D007052:Ibuprofen