Identification of HLA-B*56 variant (B*560502) in the Korean population.
We report here a new HLA-B*56 allele, B*560502, identified by sequencing-based typing in the Korean population. HLA-B*560502 differs from B*560501 by a single nucleotide at position 141 in exon 2 (T(r)C). This single nucleotide substitution may not result in an amino acid difference in the alpha1 domain at residue 23. The putative haplotype involving B*560502 may be A*24-DRB1*1201-DQA1*0503-DQB1*0304-DPB1*0202.
Pyo
C-W
CW
Catholic Hemopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Ku, Seoul 137-701, Korea.
Hur
S-S
SS
Kim
D-W
DW
Kim
C-C
CC
Han
H
H
Kim
T-G
TG
D000483:Alleles; D001483:Base Sequence; D005091:Exons / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D017354:Point Mutation; D017434:Protein Structure, Tertiary / Q000235:genetics; D016415:Sequence Alignment
D015235:HLA-B Antigens; C492823:HLA-B*56:05:02 antigen; C056079:HLA-B56 antigen