Synthesis and antihyperglycemic activity of chalcone based aryloxypropanolamines.
A series of aryloxypropanolamines (5a-r) of different chalcones (3a-e) were synthesized and evaluated for antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models. Among them compounds 5a, g, m, o, p and r showed significant reduction in blood glucose levels in both SLM and STZ animal models.
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
M
M
Satyanarayana
Priti
P
Tiwari
Brajendra K
BK
Tripathi
A K
AK
Srivastava
Ram
R
Pratap
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D011412:Propanolamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin; D013329:Structure-Activity Relationship; D013395:Sucrose
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D011412:Propanolamines; D013395:Sucrose; D002599:Chalcone; D013311:Streptozocin