Cardiovascular manifestations of acute intracranial lesions: pathophysiology, manifestations, and treatment.
The objective of this article was to review the effects of acute intracranial lesions on myocardial function. The authors reviewed scientific and clinical literature retrieved from a computerized MEDLINE search from January 1965 through January 2002. Pertinent literature was referenced, including clinical and laboratory investigations, to demonstrate the effects of acute intracranial lesions on the cardiovascular system. The literature was reviewed to summarize the mechanisms of cardiac damage and clinical manifestations and treatment of cardiovascular dysfunction caused by acute intracranial lesions. Myocardial damage and rhythm disturbances were shown to occur with acute intracranial neurological disease. The subgroup of patients used in this study formed a substantial pool of cardiac donors for cardiac transplantation. The pathophysiology of myocardial dysfunction and the optimal management continues to be a source of debate. In this article, the authors will review the anatomy, the available evidence of the pathophysiology, and the management of this complex group of patients. They will also discuss areas that need to be further investigated. Cardiovascular effects of acute intracranial lesions are common and contribute to increased morbidity and mortality.
Department of Medicine, Division of Cardiology, Toshiba Stroke Research Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo 14209-1194, USA.
Dinesh
D
Arab
Abutaher M
AM
Yahia
Adnan I
AI
Qureshi
D000208:Acute Disease; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D015415:Biomarkers; D001932:Brain Neoplasms / Q000150:complications*; D009202:Cardiomyopathies / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D002490:Central Nervous System / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography; D004638:Emergency Treatment / Q000379:methods; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology / Q000503:physiopathology; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008403:Mass Screening; D009017:Morbidity; D010808:Physical Examination
D015415:Biomarkers