The role of genetic and environmental factors in the development of T-cell mediated allergic disease in early life.
Cognate immunity to inhalant allergens is virtually universal within the adult population, but in the majority of cases this does not progress to the development of persistent asthma. Accumulating evidence suggests that progression from moderate to severe allergic disease is associated with a series of host and environmental factors operative during early childhood which interact to increase risk for both allergic sensitisation and severe respiratory infection, within the same subjects.
Holt
Patrick G
PG
Telethon Institute for Child Health Research, The University of Western Australia, Perth, Western Australia. patrick@ichr.uwa.edu.au
D000328:Adult; D000367:Age Factors; D000485:Allergens / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004777:Environment; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000235:genetics; D001239:Inhalation; D012141:Respiratory Tract Infections / Q000276:immunology / Q000821:virology; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000485:Allergens