[Multiplicity of inferences in clinical trials: adjustment methods, clinical interpretation issues].
Multiplicity of inferences is present in a large majority of clinical trials and conducts to false analyses or interpretation issues. The main risk consists in false positive conclusions. A large number of statistical methods is available for controlling the rate of false positive conclusions. But formal adjustment is not necessary in all cases and depends on the aims of the study.
Les Entreprises du Médicament, 88, rue de la Faisanderie, 75782 Paris Cedex 16, France. cjouan-flahault@leem.org
Chrystel
C
Jouan-Flahault
Florence
F
Casset-Semanaz
Pascal
P
Minini
D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003627:Data Interpretation, Statistical; D006801:Humans; D012107:Research Design