Sex differences and hormonal effects in a model of preterm infant brain injury.
Premature infants are at an exceptionally high risk for brain injury, with damage resulting in permanent behavioral deficits. A contributing factor to the severity of brain injury is gender, with males more sensitive to insult than females. The role of gender and early hormonal environment in addressed in our novel model of prenatal brain damage.
Department of Physiology, University of Maryland-Baltimore, Baltimore, MD 21201, USA. jnune001@umaryland.edu
Joseph L
JL
Nuñez
Margaret M
MM
McCarthy
D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage / Q000009:adverse effects*; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D002534:Hypoxia, Brain / Q000378:metabolism*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009118:Muscimol / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D012737:Sex Factors
D018755:GABA Agonists; D009118:Muscimol