Activated protein C resistance in preeclampsia.
OBJECTIVE
Recently. hereditary and acquired diseases that lead to thromboembolic events by changing the hemostatic balance have attracted interest as a cause of preeclampsia. In this study the incidence of activated protein C resistance (APCR) in preeclamptic women was evaluated.


METHODS
Activated protein C sensitivity ratio (APC-SR) was measured by the modified activated partial thromboplastin time (APTT) method in 19 preeclamptic and 12 healthy pregnant women and 26 normal women as the controls. Results below the levels of 2 were accepted as the presence of APCR.


RESULTS
Median APC-SR values of 2.12 and 2.01 in preeclamptic and healthy pregnant women, respectively, were found significantly lower than the normal control values of 2.31 (p = 0.0005, p = 0.001). APCR was detected in 31% of preeclamptic patients, 16.6% of healthy pregnant women and 7.6% of normal controls.


CONCLUSIONS
APCR was found significantly higher in preeclamptic women and it may play an important role in the pathogenesis of preeclampsia.
Cagirgan
S
S
Division of Hematology, Department of Internal Medicine, Ege University Faculty of Medicine, Izmir, Turkey.
Donmez
A
A
Ispahi
C
C
D020016:Activated Protein C Resistance / Q000453:epidemiology*; D000328:Adult; D015897:Comorbidity; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy