Alpha-melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis.
We investigated the effect of alpha-melanocyte stimulating hormone (alpha-MSH) on cerulein induced acute pancreatitis in rats. alpha-MSH treatment (50 microg per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity of the lesions microscopically. These data suggest that alpha-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release.
Department of Physiology, School of Medicine, Marmara University, 81326 Haydarpaşa, Istanbul, Turkey.
Nermina
N
Jahovic
Serap
S
Arbak
Ozgür
O
Tekeli
Inci
I
Alican
D000818:Animals; D002108:Ceruletide / Q000494:pharmacology*; D005260:Female; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000293:injuries; D010195:Pancreatitis / Q000139:chemically induced* / Q000188:drug therapy; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D000521:alpha-MSH / Q000494:pharmacology* / Q000627:therapeutic use
D005765:Gastrointestinal Agents; D000521:alpha-MSH; D002108:Ceruletide; D009195:Peroxidase