Gold glyconanoparticles as new tools in antiadhesive therapy.
Gold glyconanoparticles (GNPs) have been prepared as new multivalent tools that mimic glycosphingolipids on the cell surface. GNPs are highly soluble under physiological conditions, stable against enzymatic degradation and nontoxic. Thereby GNPs open up a novel promising multivalent platform for biological applications. It has recently been demonstrated that specific tumor-associated carbohydrate antigens (glycosphingolipids and glycoproteins) are involved in the initial step of tumor spreading. A mouse melanoma model was selected to test glyconanoparticles as possible inhibitors of experimental lung metastasis. A carbohydrate-carbohydrate interaction is proposed as the first recognition step for this process. Glyconanoparticles presenting lactose (lacto-GNPs) have been used successfully to significantly reduce the progression of experimental metastasis. This result shows for the first time a clear biological effect of lacto-GNPs, demonstrating the potential application of this glyconanotechnology in biological processes.
Rojo
Javier
J
Grupo de Carbohidratos, Laboratorio de Gliconanotecnología, Instituto de Investigaciones Químicas, CSIC, Américo Vespucio s/n, 41092 Sevilla, Spain.
Díaz
Vicente
V
de la Fuente
Jesús M
JM
Segura
Inmaculada
I
Barrientos
Africa G
AG
Riese
Hans H
HH
Bernad
Antonio
A
Penadés
Soledad
S
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D006028:Glycosphingolipids; D006046:Gold / Q000627:therapeutic use*; D007785:Lactose / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D018716:Molecular Mimicry; D036103:Nanotechnology / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000517:prevention & control; D010316:Particle Size; D016896:Treatment Outcome
D006028:Glycosphingolipids; D006046:Gold; D007785:Lactose