Metabolite profiling as an aid to metabolic engineering in plants.
The past decade has seen some impressive successes in the metabolic engineering of biotechnologically important plant pathways. However, plant metabolic engineering currently proceeds more by trial and error than by intelligent system design. A change in philosophy away from studying pathways in isolation and towards studying metabolism as a network is necessary. To support this development, improvements in technologies for metabolic analysis, a wider adoption of metabolite-profiling approaches and significant innovations in data analysis methodologies are required.
Trethewey
Richard N
RN
Metanomics GmbH & Co KGaA, Tegeler Weg 33, 10589 Berlin, Germany. richard.trethewey@metanomics.de
D001709:Biotechnology / Q000379:methods; D005818:Genetic Engineering / Q000379:methods*; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D030821:Plants, Genetically Modified / Q000235:genetics / Q000378:metabolism*
D010940:Plant Proteins