Ciprofloxacin-induced acute liver injury: case report and review of literature.
Ciprofloxacin is a fluorinated quinolone antibiotic with relatively low occurrence of adverse side effects. However, increasing evidence suggests that ciprofloxacin may cause severe liver damage. Until now, 14 cases of ciprofloxacin-associated liver injuries have been reported. We describe a case of a 22-year-old male who developed hepatic failure after intake of ciprofloxacin. The patient had been treated with 2 x 250 mg ciprofloxacin per day. He presented with symptoms of acute liver failure 14 days later. Liver biopsy revealed extensive hepatocellular necrosis involving zones 3 and 2 of hepatic acini and a mixed inflammatory infiltration containing abundant eosinophils. Symptoms resolved after corticoidsteroid therapy. In the present paper, we report the clinico-pathological characteristics of a case of ciprofloxacin-associated acute hepatic failure and discuss the current literature.
Zimpfer
Annette
A
Institute of Pathology, University of Basel, Schoenbeinstrasse 40, 4003 Basel, Switzerland.
Propst
Albert
A
Mikuz
Gregor
G
Vogel
Wolfgang
W
Terracciano
Luigi
L
Stadlmann
Sylvia
S
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001706:Biopsy; D002939:Ciprofloxacin / Q000009:adverse effects*; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009336:Necrosis
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D008775:Methylprednisolone