[Gastric stromal tumors--Clinical and histopathological analysis of four cases].
BACKGROUND
The aim of this study is to present our experience concerning a rare form of gastric tumor--gastrointestinal stromal tumor (GIST).


METHODS
We reviewed data of four patients with gastric stromal tumors, which have been admitted in our department from 1998-2002.


RESULTS
There were two females and two males with age of 75, 70, 65 and 63 years old. The average duration of symptoms until hospital admission was 7 days. During surgery we discovered proximal gastric tumors with 4, 5, 10 and 20 cm in largest diameter. We performed excision of the whole tumor with a security limit of 2 cm or gastric resection (one case), without limphadenectomy. One patient developed an anastomotic fistula with a good evolution under conservative treatment. All patients left the hospital in a good condition. Histopathological and immunohistochemical study diagnosed gastric stromal tumors by identifying the CD 117 maker. Postoperatively neither one of our patients received chemotherapy or radiotherapy. One female and one male patient died of peritoneal metastasis at nine months and respectively two years after operation. The other two patients are in a good condition up to date, without metastasis, one and respectively three years after surgical treatment. CONCLUSIOUS: Correct diagnosis, complete tumor resection and surveillance are essential steps in management of gastric stromal tumors.
Neagu
S
S
Secţia Clinică Chirurgie II, Spitalul Universitar de Urgenţă Bucureşti Splaiul Independenţei, nr. 169, sector 5, Bucureşti.
Zărnescu
N O
NO
Costea
R
R
Stamatoiu
A
A
Badea
V
V
Dumitrescu
C
C
Grădinaru
S
S
Sajin
M
M
Ardeleanu
C
C
Pelmuş
M
M
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000601:surgery; D017154:Stromal Cells / Q000473:pathology; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit