Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues.
Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C]T138067 in both MCF-7 transfected with IL-1alpha tumor and MDA-MB-435 tumor are non-specific binding.
Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Xiangshu
X
Fei
Qi-Huang
QH
Zheng
Ji-Quan
JQ
Wang
K Lee
KL
Stone
Tanya D
TD
Martinez
Kathy D
KD
Miller
George W
GW
Sledge
Gary D
GD
Hutchins
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000378:metabolism*; D001682:Biological Availability; D002250:Carbon Radioisotopes / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000378:metabolism*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods*; D023041:Xenograft Model Antitumor Assays / Q000379:methods; D005464:Fluorobenzenes; D005466:Fluorocarbons; D000096926:Benzenesulfonamides
D000970:Antineoplastic Agents; D002250:Carbon Radioisotopes; D013449:Sulfonamides; C119368:batabulin; D005464:Fluorobenzenes; D005466:Fluorocarbons; D000096926:Benzenesulfonamides