[Experimental study on the reconstruction of mandibular defects with a new bioactive artificial bone nano-hydroxyapatite/polyamide-66 in dogs].
OBJECTIVE
This study was designed to investigate reconstruction of segmental defect in the mandible using a new bionic materials of nano-hydroxyapatite -polyainides-66 (n-HA/PA66).


METHODS
Two defects (15 mm x 10 mm x 5 mm) were created in the mandibular bodies of dogs. One of defects was reconstructed with n-HA/PA66, another not repaired as a blank control. At 2, 4, 8, 12, 16 weeks after operation. Evaluation of effects of n-HA/PA66 on reconstruction of the mandibular defects was carried out by means of radiography and histology.


RESULTS
From 2 to 8 weeks after operation, some fiber tissue grew into the space between n-HA/PA66 and mandibular bone. The ossification was observed at 12 weeks post-operation. At 16 weeks, the n-HA/PA66 was connected directly to the mandibular bone by the newborn bone.


CONCLUSIONS
The new artificial bone of n-HA/PA66 has the effects of osteoconduction and osteoinduction, with a good biocompatibility and is an ideal bone substitute material for reconstruction of mandibular defect.
Department of Oral Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Qian
Q
Zheng
Li-Wei
LW
Zhou
Shi-Cheng
SC
Wei
Yu-Bao
YB
Li
Jie
J
Wei
D000818:Animals; D018786:Bone Substitutes; D004285:Dogs; D017886:Durapatite; D008297:Male; D008334:Mandible / Q000601:surgery*; D009757:Nylons; D019651:Plastic Surgery Procedures
D018786:Bone Substitutes; D009757:Nylons; D017886:Durapatite