[Effects of repeated lower g exposures on high-G induced memory and balance changes in rats].
OBJECTIVE
To study the protective effects of repeated +4 Gz/3 min exposures on memory and balance changes induced by +10 Gz/5 min exposure in rats.


METHODS
32 male SD rats were randomly divided into 4 groups: control group (C) ; +10 Gz/5 min group (10 Gz); 3 d training group (3 d) ; 5 d training (5 d) group (exposed to +4 Gz/3 min per day for 3 or 5 days before +10 Gz/5 min exposure). Changes of memory and balance in rats of all the 4 groups were observed after +10 Gz/5 min exposure.


RESULTS
In +10 Gz group, the percentage of correct reaction (CR) decreased significantly at all times after +10 Gz exposure (P<0.01), and the reaction time (RT) lengthened significantly at all times after +10 Gz exposure (P<0.01); as compared with control group. In 3 d training group, CR decreased significantly at 1 d, 2 d and 6 d after +10 Gz exposure (P<0.05), RT lengthened significantly at all times after +10 Gz exposure (P<0.05); as compared with control group. CR increased significantly at 2 d, 4 d and 6 d after +10 Gz exposure (P<0.01), RT shortened significantly at 1 d, 2 d, 4 d and 6 d after +10 Gz exposure (P<0.01) as compared with +10 Gz group. In 5 d training group, there were no apparent changes compared to control group; but CR increased significantly and RT shortened significantly at the time of 1 d, 2 d, 4 d and 6 d after +10 Gz exposure (P<0.01) as compared with +10 Gz group. Balancing function (BF) of +10 Gz group decreased significantly immediately and 2 d after +10 Gz exposure (P<0.01) as compared with control group. BF in 3 d and 5 d training group improved significantly immediately and 2 d after +10 Gz exposure as compared with +10 Gz group (P<0.01).


CONCLUSIONS
It is suggested that repeated low +Gz exposures could provide protective effect on memory and balance changes induced by high +Gz exposure in rats.
Cao
Xin-sheng
XS
Sun
Xi-qing
XQ
Wei
Ying-bo
YB
Yao
Yong-jie
YJ
Feng
Dai-ya
DY
Yang
Chang-bin
CB
D000054:Acceleration; D000818:Animals; D018471:Hypergravity; D008297:Male; D008568:Memory / Q000502:physiology*; D004856:Postural Balance / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology*; D013997:Time Factors