Pael-R is accumulated in Lewy bodies of Parkinson's disease.
We examined the distribution of Pael-R, a newly identified substrate for Parkin, in Parkinson's disease (PD) and multiple system atrophy (MSA). Pael-R, Parkin, alpha-synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael-R was localized in the core of LBs. Parkin and alpha-synuclein accumulated in the halo, neuronal cell bodies, and processes. These findings potentially suggest the involvement of Pael-R in LB formation, and protection role of Parkin in Pael-R-mediated neurotoxicity in PD. The absence of Pael-R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs.
Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Tetsuro
T
Murakami
Mikio
M
Shoji
Yuzuru
Y
Imai
Haruhisa
H
Inoue
Takeshi
T
Kawarabayashi
Etsuro
E
Matsubara
Yasuo
Y
Harigaya
Atsushi
A
Sasaki
Ryosuke
R
Takahashi
Koji
K
Abe
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000166:cytology / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D016631:Lewy Bodies / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016501:Neurites / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D051843:Synucleins; D025801:Ubiquitin / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D051844:alpha-Synuclein
C480827:GPR37 receptor, human; D009419:Nerve Tissue Proteins; D043562:Receptors, G-Protein-Coupled; C497604:SNCA protein, human; D051843:Synucleins; D025801:Ubiquitin; D051844:alpha-Synuclein; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein