Vitamin D receptor, oestrogen receptor-alpha and calcium-sensing receptor genotypes, bone mineral density and biochemical markers in Paget's disease of bone.
OBJECTIVE
The significance of genetic polymorphisms in the development of Paget's disease of bone is unclear at present.


METHODS
We analysed the BsmI polymorphism of the vitamin D receptor (VDR) gene, the PvuII and XbaI polymorphisms of the oestrogen receptor-alpha (ER alpha) gene, and the A986S polymorphism of the calcium-sensing receptor (CaSR) gene in 69 pagetic patients and 120 healthy subjects. We also examined the relationship of these polymorphisms with lumbar spine and femoral neck BMD as well as with biochemical parameters (serum alkaline phosphatase, osteocalcin and parathyroid hormone) in Paget's disease.


RESULTS
The XbaI and PvuII genotype distributions of the ER alpha gene were significantly different between patients with Paget's disease and control subjects (P<0.001). Also, the CaSR A986S genotype frequency was significantly different between pagetic patients and controls (P<0.01). No significant effect of gene polymorphisms on BMD or biochemical parameters of bone turnover was observed.


CONCLUSIONS
Our results suggest that the ER alpha PvuII/XbaI and CaSR A986S polymorphisms may contribute to genetic susceptibility to Paget's disease. However, further studies are required to investigate the underlying pathomechanism and to replicate the associations.
National Institute of Rheumatology and Physiotherapy, Budapest, Hungary. orfireuma@axelero.hu
J
J
Donáth
G
G
Speer
G
G
Poór
P
P
Gergely
A
A
Tabák
P
P
Lakatos
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D047628:Estrogen Receptor alpha; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics; D044169:Receptors, Calcium-Sensing / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics; D011987:Receptors, Steroid / Q000235:genetics*
D015415:Biomarkers; D047628:Estrogen Receptor alpha; D018167:Receptors, Calcitriol; D044169:Receptors, Calcium-Sensing; D011960:Receptors, Estrogen; D011987:Receptors, Steroid