[Comparative in vitro study of various titanium compounds on the immune system].
The "in vitro" immune effects of different Ti compounds on peripheral blood mononuclear cells (PBMC) were determined. The results show that Ti dioxide is not immunotoxic; Ti oxalate is strongly immunotoxic; titanocene inhibits cytokine release but not PBMC proliferation, while Ti ascorbate inhibits TNF-alpha release from PBMC but not that of IFN-gamma. The results show that Ti toxicity depends on speciation.
Sezione di Medicina del Lavoro, Allergologia ed Immunologia Clinica del Dipartimento di Medicina e Scienze dell'Invecchiamento, Università G. D'Annunzio, Chieti.
M
M
Russi
G
G
Meliddo
E
E
Toto
L
L
Di Giampaolo
P
P
Travaglino
M
M
Appignani
M
M
Di Gioacchino
P
P
Boscolo
D004305:Dose-Response Relationship, Drug; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000276:immunology; D014025:Titanium / Q000633:toxicity*
D014025:Titanium