Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family.
The EDEN gene superfamily comprises genes that contain the EMI domain, a structural motif recently identified in proteins of the extracellular matrix. We report here the detailed expression pattern of genes of the EMILIN/Multimerin family, the most numerous group of EDEN superfamily, during mouse development. In situ hybridization has revealed that the EMILIN/Multimerin genes are particularly expressed in the cardio-vascular system and in mesenchymal cells. In general, the territories of expression of each gene are partially overlapping or complementary with that of other members of the family and, usually, more than one gene of the family is active in different tissues, consistent with the possibility of functional compensation. The analysis is particularly relevant in the interpretation of gene targeting experiments.
Braghetta
Paola
P
Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy.
Ferrari
Alessandra
A
De Gemmis
Paola
P
Zanetti
Miriam
M
Volpin
Dino
D
Bonaldo
Paolo
P
Bressan
Giorgio M
GM
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism*; D002319:Cardiovascular System / Q000196:embryology / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D042783:Endothelial Cells / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism*; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D051379:Mice; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D009626:Terminology as Topic; D014018:Tissue Distribution
D001798:Blood Proteins; D008562:Membrane Glycoproteins; C030340:elastin microfibril interface located protein; C069282:multimerin