Erythema multiforme during cytomegalovirus infection and oral therapy with terbinafine: a virus-drug interaction.
The authors report a case of erythema multiforme in a 32-year-old woman who was also taking oral terbinafine for an onychomycosis. The patient data analysis showed serological positivity for cytomegalovirus (IgM and IgG) and hepatitis C virus and serological titre of antinuclear antibody was elevated. After a brief review of the literature the authors propose the possibility of virus-drug interaction as a model of adverse drug reactions.
Carducci
M
M
Department of Inflammatory, Istituto San Gallicano, Via Elio Chianesi, 53, 00144 Rome, Italy. macard@ifo.it
Latini
A
A
Acierno
F
F
Amantea
A
A
Capitanio
B
B
Santucci
B
B
D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000150:complications*; D003875:Drug Eruptions / Q000209:etiology* / Q000821:virology; D004892:Erythema Multiforme / Q000139:chemically induced* / Q000821:virology*; D005260:Female; D006801:Humans; D009281:Naphthalenes / Q000009:adverse effects*; D014009:Onychomycosis / Q000150:complications / Q000188:drug therapy; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine