[Gastrointestinal stromal tumors. Current data].
GIST anatomical concept, recently elucidate, they are characterized by the expression of the protooncogene C Kit The diagnosis is relatively easy but prognosis evaluation is not usually possible. The treatment is based on the surgical resection. The rewardable clinical response of tumors that express C-Kit to treatment with the tyrosine kinase inhibitor STI 571 is a triumph of molecular pharmacology.
Service d'hépatogastroentérologie, CHU Sahloul, Sousse, Tunisie.
Dalenda
D
Arfaoui
Mohamed Tahar
MT
Yacoubi
Héla
H
Elloumi
Foued
F
Frikha
Muncef
M
Mokni
Salem
S
Ajmi
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D002277:Carcinoma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000627:therapeutic use; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D011743:Pyrimidines / Q000627:therapeutic use; D017154:Stromal Cells
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D019009:Proto-Oncogene Proteins c-kit