[Comparative morphofunctional characteristics of the ovaries in women of reproduction age in the norm and with chronic anovulatory infertility].
This work was aimed at the study of ovarian histophysiology in patients with chronic anovulation. The biopsy specimens obtained by endoscopic laparoscopy from the ovaries of women of reproductive age with anovulation or normal cycle (control) were examined. It was found that in the ovaries of anovulation patients the thickness of both tunica albuginea and follicular theca externa was increased. The number of primordial follicles was not different in groups studied, while the number of antral follicles was decreased in anovulation group. No differences in 3 beta-hydroxysteroiddehydrogenase and NADH-dehydrogenase activities in the cells of theca interna and cyst walls were found in both groups, while NADPH-dehydrogenase and NO-synthase activities in these structures were reduced in anovulation. Reduction of estradiol concentration and increase of testosterone concentration were noted in blood of women with anovulatory infertility. The data obtained can be used for the analysis of etiology and pathogenesis of anovulatory infertility and for development of the methods of its treatment.
Department of Histology, Cytology and Embryology, Far-Eastern State Medical University, Division of Endoscopic Gynecology, 10th Municipal Hospital, Khabarovsk.
B Ia
BIa
Ryzhavskiĭ
I V
IV
Smirenina
E P
EP
Shapiro
D000293:Adolescent; D000328:Adult; D000858:Anovulation / Q000150:complications / Q000473:pathology*; D001706:Biopsy; D002908:Chronic Disease; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology*; D010535:Laparoscopy; D019001:Nitric Oxide Synthase / Q000378:metabolism; D006080:Ovarian Follicle / Q000473:pathology / Q000502:physiology; D010053:Ovary / Q000201:enzymology / Q000378:metabolism / Q000473:pathology* / Q000502:physiology; D010088:Oxidoreductases / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D004958:Estradiol; D010088:Oxidoreductases; D019001:Nitric Oxide Synthase