Microwave-assisted organic synthesis using minivials to optimize and expedite the synthesis of diverse purine libraries.
The new Personal Chemistry ultralow-volume (0.2-0.5 mL) minivials are shown to enable small-scale optimization and synthesis of purines at optimal reaction concentrations (0.1-0.4 M), thereby increasing the overall efficiency of this microwave-assisted library synthesis.
Discovery Chemistry, Experimental Station, Incyte Corporation, Route 141 and Henry Clay Road, Wilmington, DE 19880, USA.
Amy G
AG
Takvorian
Andrew P
AP
Combs
D000588:Amines / Q000138:chemical synthesis; D006361:Heating; D008832:Microchemistry / Q000379:methods; D008872:Microwaves; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
D000588:Amines; D011687:Purines; D012997:Solvents; C030985:purine