Xanthohumol metabolites in faeces of rats.
Xanthohumol (1), isolated from hop, was fed to rats in a dose of 1000 mg kg(-1) body weight. The faeces of the animals were collected after 24 and 48 h and analysed for metabolites of 1. Approximately 89% of the recovered flavonoid-compounds consisted of unchanged 1. Sixteen metabolites and six previously known metabolites were isolated and characterized by coupling techniques (HPLC-NMR, HPLC-MS and HPLC-DAD). Their structures were elucidated by spectroscopic methods, especially using NMR spectroscopy. Twenty metabolites had a modified chalcone structure and two metabolites were flavanone derivatives.
Institute for Pharmacognosy and Analytical Phytochemistry, University of the Saarland, 66041 Saarbrücken, Germany.
Aslieh
A
Nookandeh
Norbert
N
Frank
Frank
F
Steiner
Renate
R
Ellinger
Bernd
B
Schneider
Clarissa
C
Gerhäuser
Hans
H
Becker
D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005243:Feces / Q000737:chemistry*; D005260:Female; D005419:Flavonoids; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011427:Propiophenones / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D005419:Flavonoids; D011427:Propiophenones; C104536:xanthohumol