Therapeutic angiogenesis: a biologic bypass.
The use of angiogenic factors to effect therapeutic angiogenesis may be an attractive treatment modality for a substantial number of patients who have diffuse coronary artery disease and who are not candidates for traditional revascularization procedures. Delivery of angiogenic factors as a protein or gene encoding for the respective protein product has been shown to induce angiogenesis in numerous animal models, and expression of a functioning product has been demonstrated. Various early clinical trials of therapeutic angiogenesis have shown reduction in anginal symptoms and increases in exercise time, as well as objective evidence of improved perfusion, left ventricular function and angiographic appearance following such angiogenic treatments.
Evanston Northwestern Healthcare, Evanston, IL, USA.
Imran S
IS
Syed
Timothy A
TA
Sanborn
Todd K
TK
Rosengart
D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage*; D042501:Angiogenic Proteins / Q000008:administration & dosage* / Q000235:genetics*; D000818:Animals; D002986:Clinical Trials as Topic; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D004195:Disease Models, Animal; D005346:Fibroblast Growth Factors / Q000008:administration & dosage / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage / Q000235:genetics; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy*
D043925:Angiogenesis Inducing Agents; D042501:Angiogenic Proteins; D011994:Recombinant Proteins; D042461:Vascular Endothelial Growth Factor A; D005346:Fibroblast Growth Factors