Antiproliferative effects of abietane diterpenes from Aegiphila lhotzkyana.
Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been described for this species. These compounds were tested for their antiproliferative effects on tumor cell lines using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl- 2H-tetrazolium bromide (MTT) assay and on sea urchin egg development, as well as for their lytic properties on mouse erythrocytes. All diterpenes reduced the viability of tumor cells and inhibited sea urchin egg cleavage. None of the tested compounds presented hemolytic activity.
Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Letícia Veras
LV
Costa-Lotufo
Edilberto Rocha
ER
Silveira
Maria Claudia
MC
Barros
Mary Anne
MA
Lima
Maria Elisabete
ME
De Moraes
Manoel Odorico
MO
De Moraes
Cláudia
C
Pessoa
D045784:Abietanes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D010063:Ovum / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D012617:Sea Urchins; D029648:Verbenaceae
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts