PEGylation of liposome decreases the susceptibility of liposomal drug in cancer photodynamic therapy.
For the purpose of the avoidance of reticuloendothelial system (RES)-trapping, liposome entrapped benzoporphyrin derivative monoacid ring A (BPD-MA), which is used for cancer photodynamic therapy (PDT), was modified with polyethylene glycol (PEG-LipBPD-MA). Tumor accumulation of BPD-MA at 3 h after injection with PEG-LipBPD-MA in Meth A-sarcoma-bearing mice was significantly higher than that after injection with non-modified liposomal BPD-MA (Cont-LipBPD-MA) as expected. On the contrary, significant tumor growth suppression after PDT was observed only for Cont-LipBPD-MA but not for PEG-LipBPD-MA. Thus, PEGylation enhances the passive targeting of liposomal BPD-MA in tumor, but decreases the susceptibility of the drug in PDT.
University of Shizuoka School of Pharmaceutical Sciences, Yada, Shizuoka, Japan.
Kanae
K
Ichikawa
Tomoya
T
Hikita
Noriyuki
N
Maeda
Yoshito
Y
Takeuchi
Yukihiro
Y
Namba
Naoto
N
Oku
D000818:Animals; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011166:Porphyrins / Q000008:administration & dosage* / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013678:Technology, Pharmaceutical / Q000379:methods
D008081:Liposomes; D017319:Photosensitizing Agents; D011166:Porphyrins; C504224:benzoporphyrin D; D011092:Polyethylene Glycols