[IgM antiphospholipical antibodies in preeclampsia-eclampsia].
BACKGROUND
Antiphospholipid antibodies are associated with thrombocytopenia and fetal loss, and have been reported elevated in patients with preeclampsia-eclampsia. Site: Preeclampsia-Eclampsia Research Unit, Instituto Materno Infantil del Estado de Mexico, Toluca, Mexico and the Specialty Hospital Research Unit, La Raza Medical Center, Mexico City, Mexico.


OBJECTIVE
To determine the presence of anticardiolipin antibodies (IgG-IgM) as markers of acute endothelial damage in patients with preeclampsia.


METHODS
A randomized case control study composed of two groups: Group A (cases), 18 patients with preeclampsia-eclampsia and group B (control), 18 normal pregnancies. Antiphospholipid (anticardiolipin) antibodies were determined in both groups in addition to with coagulation tests and clinical variables in mother and newborn in day of admission and nine weeks after obstetrical resolution. We excluded patients with anticoagulant or dialysis therapy, taking NSAIDs or who recently required transfusion or plasmaferesis.


RESULTS
There were significant differences in levels of IgM and in weights and mortality among newborns between the two groups. In terms of maternal complications, we found HELLP syndrome as leading cause. We also observed in the case group significant differences in mean arterial pressure (MAP) and IgM levels between admission day and nine weeks later. Our results lead us to the conclusion that there must be exist immunologic mechanism that induces synthesis of anticardiolipin antibodies (IgM isotype) during acute state of the disease, accounting for vascular changes and prothrombotic state responsible for maternal and neonatal complications.
Unidad de Investigación en Preeclampsia-Eclampsia, Instituto Materno-Infantil del Estado de México, Laguna de Colores No. 101, Esq. Lago Caimanero, C.P. 50100, Toluca, Edo. de Méx., México.
Jesús Carlos
JC
Briones-Garduño
Manuel
M
Díaz de León-Ponce
Ernesto
E
Barrios-Prieto
José Daniel
JD
Salazar-Exaire
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood* / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011897:Random Allocation
D017152:Antibodies, Antiphospholipid; D007075:Immunoglobulin M