Mysteries of the transferrin-transferrin receptor 1 interaction uncovered.
How does the iron (Fe) binding protein, transferrin (Tf), bind to the transferrin receptor 1 (TfR1) to donate Fe to cells? In this issue of Cell, Cheng et al., describe the molecular structure of the human TfR1-Tf complex, This atomic model shows that Tf binds laterally to the TfR1 dimer and extends into the gap between the bottom of the receptor ectodomain and the membrane.
Children's Cancer Institute Australia for Medical Research, The Iron Metabolism and Chelation Program, PO Box 81, High Street, Randwick, Sydney, New South Wales 2031, Australia.
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D000818:Animals; D006801:Humans; D007501:Iron / Q000378:metabolism; D008954:Models, Biological; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011990:Receptors, Transferrin / Q000737:chemistry / Q000378:metabolism*; D014168:Transferrin / Q000737:chemistry / Q000378:metabolism*
D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron