Detection of influenza antigen with rapid antibody-based tests after intranasal influenza vaccination (FluMist).
Rapid tests for influenza antigen detection are frequently used, but it is not known how receipt of intranasal influenza vaccine affects results of these tests. We tested healthy adults who received either intranasal or intramuscular influenza vaccine. Of the 14 intranasal vaccine recipients, 7 (50%) had a direct fluorescent antibody test (DFA) result and 2 (14%) had an enzyme immunoassay (EIA) result that was positive for influenza antigen within 7 days after vaccination. No subjects had positive EIA results on day 12 or 13 after vaccination. For some intranasal vaccine recipients, rapid influenza-antigen detection tests yield positive results within 1 week after vaccination.
Infectious Diseases Division, Massachusetts General Hospital, Boston, Massachusetts 02114-2696, USA.
Tanya
T
Ali
Nathaniel
N
Scott
Wendy
W
Kallas
Mary Ellen
ME
Halliwell
Carol
C
Savino
Eric
E
Rosenberg
MaryJane
M
Ferraro
Elizabeth
E
Hohmann
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis*; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry*; D007252:Influenza Vaccines / Q000276:immunology*; D008875:Middle Aged; D013997:Time Factors; D014611:Vaccination
D000956:Antigens, Viral; D007252:Influenza Vaccines