Fragmentation studies on tetronasin by accurate-mass electrospray tandem mass spectrometry.
We report here the first full fragmentation study of tetronasin 1. Fragmentation was carried out by high-resolution ESI-CID-MS(n). The formulae of the fragment ions were determined by accurate mass measurements. It is demonstrated that the fragmentation routes observed derive essentially from a first loss of water via two different mechanisms. One minor route consists of a charge remote neutral loss and the second major route occurs via the formation of a carbocation. The fragments obtained from this carbocation were produced by subsequent complex neutral eliminations and the structures were inferred, in some cases, by carbocation stability.
Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Tatiana
T
Fonseca
Norberto P
NP
Lopes
Paul J
PJ
Gates
James
J
Staunton
D000900:Anti-Bacterial Agents / Q000737:chemistry; D002138:Calibration; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*; D013291:Streptococcus / Q000737:chemistry
D000900:Anti-Bacterial Agents; D005663:Furans; C055416:tetronasin