Abnormalities in MRI-measured signal intensity in the corpus callosum in schizophrenia.
The microstructural integrity of the corpus callosum (CC) in first-episode schizophrenia patients was assessed by measuring the signal intensity (SI) in T1-weighted MRI images. Analyses revealed that compared to both healthy controls and non-schizophrenic patients, schizophrenia patients showed reductions in SI in all the callosal subregions, the genu, body, isthmus and splenium in first-episode schizophrenia. These results indicate that schizophrenia is characterized by pathology of this principal interhemispheric commissure; the abnormalities may reflect distributed (rather than localized) interhemispheric disconnectivity that extends beyond the heteromodal association cortices.
Diwadkar
Vaibhav A
VA
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA.
DeBellis
Michael D
MD
Sweeney
John A
JA
Pettegrew
Jay W
JW
Keshavan
Matcheri S
MS
D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D001931:Brain Mapping; D010054:Brief Psychiatric Rating Scale; D016009:Chi-Square Distribution; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology; D012569:Schizotypal Personality Disorder / Q000209:etiology / Q000473:pathology