Design and synthesis of a novel family of semi-rigid ligands: versatile compounds for the preparation of 99mTc radiopharmaceuticals.
Synthetic pathways to a range of novel semi-rigid tetradentate ligands, with sulfur, amido or amino donor groups, designed to coordinate technetium 99m have been developed. The technetium-99m complexes have been prepared and their stabilities in serum and by metathesis reaction via cysteine exchange reactions were compared. HPLC comparison of two (99m)Tc-complexes and their rhenium analogues led to the first proof of the nature of our radioactive complexes.
Laboratoire de Chimie Inorganique, EA 807, Université Paul Sabatier, Bat. IIR1, 118, route de Narbonne, 31062 Toulouse, France.
Julien
J
Le Gal
Laure
L
Latapie
Marie
M
Gressier
Yvon
Y
Coulais
Michèle
M
Dartiguenave
Eric
E
Benoist