Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
This report describes the first human study of a novel amyloid-imaging positron emission tomography (PET) tracer, termed Pittsburgh Compound-B (PIB), in 16 patients with diagnosed mild AD and 9 controls. Compared with controls, AD patients typically showed marked retention of PIB in areas of association cortex known to contain large amounts of amyloid deposits in AD. In the AD patient group, PIB retention was increased most prominently in frontal cortex (1.94-fold, p = 0.0001). Large increases also were observed in parietal (1.71-fold, p = 0.0002), temporal (1.52-fold, p = 0.002), and occipital (1.54-fold, p = 0.002) cortex and the striatum (1.76-fold, p = 0.0001). PIB retention was equivalent in AD patients and controls in areas known to be relatively unaffected by amyloid deposition (such as subcortical white matter, pons, and cerebellum). Studies in three young (21 years) and six older healthy controls (69.5 +/- 11 years) showed low PIB retention in cortical areas and no significant group differences between young and older controls. In cortical areas, PIB retention correlated inversely with cerebral glucose metabolism determined with 18F-fluorodeoxyglucose. This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects.
Klunk
William E
WE
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
Engler
Henry
H
Nordberg
Agneta
A
Wang
Yanming
Y
Blomqvist
Gunnar
G
Holt
Daniel P
DP
Bergström
Mats
M
Savitcheva
Irina
I
Huang
Guo-feng
GF
Estrada
Sergio
S
Ausén
Birgitta
B
Debnath
Manik L
ML
Barletta
Julien
J
Price
Julie C
JC
Sandell
Johan
J
Lopresti
Brian J
BJ
Wall
Anders
A
Koivisto
Pernilla
P
Antoni
Gunnar
G
Mathis
Chester A
CA
Långström
Bengt
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D000682:Amyloid / Q000378:metabolism*; D000814:Aniline Compounds / Q000097:blood / Q000737:chemistry; D001345:Autoradiography / Q000379:methods; D001665:Binding Sites; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D001923:Brain Chemistry; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D013844:Thiazoles / Q000097:blood / Q000737:chemistry; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods*
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000682:Amyloid; D000814:Aniline Compounds; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18; D005947:Glucose