Syntheses and biological evaluation of new fluoroquinolone antibacterials containing chiral oxiimino pyrrolidine.
The design and syntheses of new fluoroquinolone antibacterial agents having pyrrolidine ring at C-7 position are described. The pyrrolidine ring is optically active and possesses methyloxime functional group. Two of them have excellent in vitro antibacterial activities and pharmacokinetic profiles.
Choi
Dong Rack
DR
Central Research Laboratory, Dong-Wha Pharm. Ind. Co. Ltd, Anyang, Kyunggi 430-017, South Korea. org301@iris.dwcrc.co.kr
Shin
Jung Han
JH
Yang
Jin
J
Yoon
Sue Hye
SH
Jung
Yong Ho
YH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D024841:Fluoroquinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D011759:Pyrrolidines