Transitional cell carcinoma of the bladder producing parathyroid hormone-related protein (PTHrP).
Hypercalcemia associated with transitional cell carcinoma (TCC) is rarely encountered. We report a case of TCC of bladder with documented production of parathyroid hormone related protein (PTHrP). Our patient had a rapidly progressive course and died 2 months after radical cystectomy. Literature suggests that these patients present with advanced stage and carry a poor prognosis. The histopathologic features, treatment and prognosis associated with this rare paraneoplastic syndrome are reviewed.
Department of Medicine, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA.
Uzair B
UB
Chaudhary
David L
DL
Milling
Nabil K
NK
Bissada
D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein / Q000378:metabolism*; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery
D044162:Parathyroid Hormone-Related Protein