Peroxisome proliferator-activated receptor alpha target genes.
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic compounds such as long-chain fatty acids and their derivatives on transcription of genes commonly called PPAR target genes. Here we review the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARalpha target genes.
Mandard
S
S
Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands.
Müller
M
M
Kersten
S
S
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D005227:Fatty Acids / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D020675:Peroxisomes / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000819:agonists / Q000235:genetics / Q000378:metabolism*
D005227:Fatty Acids; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors