A role for right medial prefontal cortex in accurate feeling-of-knowing judgements: evidence from patients with lesions to frontal cortex.
The hypothesis that prefrontal cortex plays a critical role in accurate predictions of episodic memory performance was tested using the feeling-of-knowing (FOK) paradigm. Fourteen patients with a broad spectrum of damage to the frontal cortex and matched controls read sentences and later were tested for recall memory, confidence judgments, and FOK accuracy using as cues the sentences with the final word missing. While frontal patients were impaired at recall and recognition memory, they were able to make accurate confidence judgments about their recall attempts. By contrast, as a group, the patients were markedly impaired in the accuracy of their prospective FOK judgments. Lesion analysis of frontal patients with clear FOK impairment revealed an overlapping region of damage in right medial prefrontal cortex. These findings provide functional and anatomical evidence for a dissociation between recall confidence and prospective memory monitoring and are discussed in terms of familiarity and access theories of FOK predictions.
Schnyer
David M
DM
Memory Disorders Research Center, Boston VA Healthcare System and Boston University School of Medicine (151A), 150 South Huntington Avenue, Boston, MA 02130-4817, USA. dschneyer@bu.edu
Verfaellie
Mieke
M
Alexander
Michael P
MP
LaFleche
Ginette
G
Nicholls
Lindsay
L
Kaszniak
Alfred W
AW
D000328:Adult; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology; D001931:Brain Mapping; D016022:Case-Control Studies; D003690:Deja Vu / Q000523:psychology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007600:Judgment / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000293:injuries / Q000502:physiology*; D011897:Random Allocation; D021641:Recognition, Psychology / Q000502:physiology; D014057:Tomography, X-Ray Computed / Q000379:methods