Electrical coupling and neuronal synchronization in the Mammalian brain.
Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generation of connexin knockouts have spurred a rapid increase in our knowledge of the role of gap junctions in neural activity. This article reviews the many subtleties of transmission mediated by gap junctions and the mechanisms whereby these junctions contribute to synchronous firing.
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. mbennett@aecom.yu.edu
Michael V L
MV
Bennett
R Suzanne
RS
Zukin
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D017630:Connexins / Q000378:metabolism; D003344:Cortical Synchronization; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D017630:Connexins