Synthesis and cytotoxic effect of carbocyclic potential minor groove binders.
New carbocyclic potential minor groove binders were synthesised, using 3-nitrobenzoyl chloride and aliphatic alpha,omega-diamines with three, four and five methylene fragments. The half structures, compounds IV-VI can be compared to bis-amidines, compounds X-XII to bis-netropsin. All of the compounds were investigated antiproliferative and cytotoxic effects in the standard cell line of mammalian tumour MCF-7.
Department of Organic Chemistry, Medical University of Białystok, Mickiewicza 2a, Białystok 15222, Poland. dbartule@amb.edu.pl
Danuta
D
Bartulewicz
Tomasz
T
Anchim
Milena
M
Dabrowska
Krystyna
K
Midura-Nowaczek
D000146:Acids, Carbocyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000146:Acids, Carbocyclic; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D004247:DNA