Molecular targets for therapeutic intervention after spinal cord injury.
In an effort to develop therapies for promoting neurological recovery after spinal cord injury, much work has been done to identify the cellular and molecular factors that control axonal regeneration within the injured central nervous system. This review summarizes the current understanding of a number of the elements within the spinal cord environment that inhibit axonal growth and outlines the factors that influence the neuron's ability to regenerate its axon after injury. Recent insights in these areas have identified important molecular pathways that are potential targets for therapeutic intervention, raising hope for victims of spinal cord injury.
International Collaboration on Repair Discoveries, Department of Orthopaedics, Department of Surgery, University of British Columbia Vancouver, British Columbia, Canada V6T 1Z4.
Brian K
BK
Kwon
Jaimie F
JF
Borisoff
Wolfram
W
Tetzlaff
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D020439:Growth Cones / Q000378:metabolism; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism; D009416:Nerve Regeneration / Q000502:physiology; D009457:Neuroglia / Q000378:metabolism; D018696:Neuroprotective Agents / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D000242:Cyclic AMP; D020741:rho GTP-Binding Proteins