Role of the lateral parabrachial nucleus in apomorphine-induced conditioned consumption reduction: cooling lesions and relationship of c-Fos-like immunoreactivity to strength of conditioning.
The following experiments were designed to determine whether the lateral parabrachial nucleus (lPBN) mediates acquisition of conditioned consumption reduction induced by apomorphine, an agent that also has reinforcing properties. Temporary cooling lesions of the PBN blocked acquisition of apomorphine-induced conditioned consumption reduction. In addition, both apomorphine and LiCl activated c-Fos-like immunoreactivity (c-FLI) in the central, external, and crescent lPBN, and there was a strong correspondence between amount of c-FLI expression and strength of conditioned consumption reduction in these subnuclei. Taken together, these results support the hypothesis that the lPBN mediates apomorphine-induced conditioned consumption reduction, as is true for LiCl. Furthermore, they raise the possibility that the specific part of the lPBN mediating this conditioning effect of apomorphine and LiCl is 1 of the 3 subnuclei.
Department of Psychology, University of Southern California, Los Angles, CA 90089-1061, USA. kchamber@usc.edu
Kathleen C
KC
Chambers
Yuan
Y
Wang
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003080:Cold Temperature / Q000009:adverse effects; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D016762:Genes, fos / Q000502:physiology*; D008297:Male; D011149:Pons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000008:administration & dosage
D013395:Sucrose; D001058:Apomorphine