Role of microsatellite instability in borderline ovarian tumors.
This study was designed to establish the role of microsatellite instability (MSI) in the development of sporadic tumors of the ovary. The instability of 6 microsatellites (BAT25, BAT26, NME1, D17S250, D5S346 and D2S123) was determined by comparing MSI in healthy and tumoral tissue in each of 40 patients undergoing surgery for a sporadic ovarian tumor. BAT26 and D2S123 instability was detected in borderline tumors, and ovarian carcinomas were found to present instability in the microsatellites BAT25, NME1 and D17S250. Our findings indicate that microsatellite instability lacks a significant role in the appearance or progression of sporadic ovarian tumors.
Sanz Casla
M T
MT
Laboratory, Biology Department, Hospital Clinico San Carlos, C/Martin Lagos s/n, 28040 Madrid, Spain.
Vidaurreta Lazaro
M
M
Almansa de Lara
I
I
Tresserra
F
F
Lopez Marin
L
L
Maestro
M L
ML
Dexeus
S
S
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology