Ocular melanoma in a Long Evans rat.
During a long-term study, a rat exposed to half-amplitude band pass fluorescent blue light (434 to 475 nm) and receiving a calcium channel blocker developed an ocular mass. By visual examination, a presumptive diagnosis of ocular melanoma was made. Subsequent surgical removal of the eye, followed by histopathology, confirmed the lesion as a highly pigmented epitheliod melanoma.
Veterinary Consultant, 2055 Mary Ann Lane, Burleson, Texas 76028-2229, USA.
Walter S
WS
Manning
Paul G
PG
Greenlee
John N
JN
Norton
D000818:Animals; D002121:Calcium Channel Blockers / Q000009:adverse effects; D003316:Corneal Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005134:Eye Neoplasms / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D006652:Histological Techniques; D008027:Light; D008545:Melanoma / Q000209:etiology / Q000473:pathology* / Q000662:veterinary*; D051381:Rats; D020318:Rats, Long-Evans; D012376:Rodent Diseases / Q000209:etiology* / Q000473:pathology
D002121:Calcium Channel Blockers