Detection of acute Epstein Barr virus cerebellitis using sequential brain HMPAO-SPECT imaging.
We used Technetium-99m hexamethyl propylene amine oxime single-photon emission computed tomography (HMPAO-SPECT) and magnetic resonance imaging (MRI) to evaluate a 30-year-old woman who developed cerebellar dysfunction after infection with Epstein Barr virus. Although no abnormal findings were evident from a brain MRI, the HMPAO-SPECT revealed increased perfusion in both cerebellar hemispheres. The patient improved without specific treatment. Two sequential HMPAO-SPECTs showed gradually reduced hyperperfusion in the cerebellum, which was correlated with her clinical recovery. We suggest that brain HMPAO-SPECT may thus be useful for identifying acute cerebellitis and predicting its clinical outcome.
Park
Jeong Wook
JW
Department of Neurology, College of Medicine, The Catholic University of Korea, South Korea. pjw516@catholic.ac.kr
Choi
Young Bin
YB
Lee
Kwang Soo
KS
D000328:Adult; D002526:Cerebellar Diseases / Q000000981:diagnostic imaging*; D002531:Cerebellum / Q000098:blood supply / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D004292:Dominance, Cerebral / Q000502:physiology; D018792:Encephalitis, Viral / Q000000981:diagnostic imaging*; D020031:Epstein-Barr Virus Infections / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D020234:Gait Ataxia / Q000000981:diagnostic imaging; D006801:Humans; D006940:Hyperemia / Q000000981:diagnostic imaging; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D009460:Neurologic Examination; D012039:Regional Blood Flow / Q000502:physiology; D012075:Remission, Spontaneous; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D019690:Technetium Tc 99m Exametazime