Extracts of Phellinus gilvus and Phellinus baumii inhibit pulmonary inflammation induced by lipopolysaccharide in rats.
Compared to saline-challenged rats, rats exposed to 50 microg intratracheal lipopolysaccharide showed an increase of total white cells (from 0.3 x 10(6) to 2.4 x 10(6)), neutrophils (from 0.09 x 10(6) to 1.8 x 10(6)), the levels of tumor necrosis factor (TNF)-alpha (from 200 pg ml(-1) to 1200 pg ml(-1)), and interleukin (IL)-1beta (from 220 pg ml(-1) to 650 pg ml(-1)) in the bronchial lavage fluid. However, after pretreatment with extracts of Phellinus gilvus and Phellinus baumii, the total white cells, neutrophils, and the level of IL-1beta in lipopolysaccharide-challenged rats were similar to those in saline-challenged rats, except for TNF-alpha. The results indicate that extracts of P. gilvus and P. baumii may be useful in preventing acute pulmonary inflammation in human diseases.
Jang
Beom-Su
BS
College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
Kim
Jong-Chun
JC
Bae
Jae-Sung
JS
Rhee
Man-Hee
MH
Jang
Kwang-Ho
KH
Song
Jae-Chan
JC
Kwon
Oh-Deog
OD
Park
Seung-Chun
SC
D000818:Animals; D001487:Basidiomycota / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology*; D002457:Cell Extracts / Q000627:therapeutic use*; D007375:Interleukin-1 / Q000032:analysis; D007958:Leukocyte Count; D008070:Lipopolysaccharides; D008297:Male; D008518:Medicine, East Asian Traditional; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D011014:Pneumonia / Q000139:chemically induced / Q000175:diagnosis* / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D002457:Cell Extracts; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha