p53 in the cytoplasm: a question of overkill?
The tumor suppressor p53 regulates cellular responses to stress by serving in the nucleus to regulate transcription of genes involved in processes including cell cycle arrest, DNA repair, and apoptosis. Nevertheless, recent papers show that p53 may have a separate cytoplasmic role in directly regulating the Bax-dependent mitochondrial pathway to cell death.
Baptiste
Nicole
N
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Prives
Carol
C
D000818:Animals; D017209:Apoptosis; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53