Attenuation of leukocyte beta 2-integrin expression by antithrombin-III.
Antithrombin-III exerts antiinflammatory effects via ligation of heparan sulfate proteoglycans. Here we show in vitro that recombinant human antithrombin-III attenuates CD11b/CD18 expression of activated neutrophils and monocytes in whole blood ex vivo. As leukocyte integrin expression is triggered by extracorporeal circulation, this observation may be of relevance for pharmacological treatment during cardiopulmonary bypass.
Department of Internal Medicine and Therapeutics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
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D
Gritti
A
A
Malinverno
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C
Gasparetto
C J
CJ
Wiedermann
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R
Ricevuti
D000328:Adult; D000990:Antithrombin III / Q000494:pharmacology*; D018821:CD18 Antigens / Q000096:biosynthesis* / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology
D018821:CD18 Antigens; D011994:Recombinant Proteins; D000990:Antithrombin III