AgNORs count correlates better than grading with the effect of chemotherapy in serous ovarian cancer.
OBJECTIVE
to evaluate the relationship between AgNORs count as well as tumor grade and the effect of chemotherapy in serous ovarian cancer.


METHODS
39 women who underwent surgical procedure and then chemotherapy due to serous ovarian cancer were included into the study. In cancer cells the mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of nuclei with five or more AgNORs (pAgNOR) were counted.


RESULTS
in 13 women (33.3%) we did not found the neoplastic disease in second-look laparotomy (group I), and in 26 patients (66.7%) the cancer was present (group II). The mean grading and the mAgNOR of ovarian cancer in the first operation in group I and in group II were similar. The mean pAgNOR in group I was higher than in group II. The values of mAgNOR and pAgNOR but not grading in women with the absence of cancer in second-look laparotomy and in women with the only single neoplastic focuses were similar one to another, and both were higher than in cases of disseminated neoplastic disease.


CONCLUSIONS
the quantitative assessment of AgNORs is better prognostic factor when compared to grading for the effectiveness of adjuvant chemotherapy in serous ovarian cancer.
I Department of Gynecology and Gynecologic Oncology, Institute of Gynecology and Obstetrics, University Medical School, Lódź. Lgottwald@wp.pl
Leszek
L
Gottwald
Marian
M
Danilewicz
Jacek
J
Suzin
Katarzyna
K
Wójcik-Krowiranda
Andrzej
A
Bieńkiewicz
D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D018284:Cystadenocarcinoma, Serous / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009697:Nucleolus Organizer Region / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D016622:Silver Staining; D016896:Treatment Outcome