[Expression of BP1 gene in adult acute leukemia].
OBJECTIVE
To explore the expression of beta protein 1 (BP1) gene in adult acute leukemia (AL) and its relationship with acute leukemia.


METHODS
Expression of BP1 gene mRNA was detected in 70 adult AL, 10 normal controls and HEL cell line, by reverse transcriptase-polymerase chain reaction (RT-PCR).


RESULTS
No detectable BP1 gene was found in peripheral blood or bone marrow cells of normal controls and 20 acute myeloid leukemia (AML) in complete remission (CR) stage. BP1 gene was highly expressed in HEL cell line, 57% (20/35) of AML and 80% (8/10) of AML-M(5) cases. BP1 gene could not be detected in adult acute lymphoid leukemia.


CONCLUSIONS
BP1 gene was highly expressed in AML. It might be used as a molecular marker of AML.
Department of Hematology, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China.
Hui
H
Li
Kai-lin
KL
Xu
Xiu-ying
XY
Pan
Hai-yan
HY
Wang
Zhen-yu
ZY
Li
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D005260:Female; D005801:Genes, Homeobox; D005914:Globins / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014157:Transcription Factors / Q000235:genetics*
C105304:DLX4 protein, human; D018398:Homeodomain Proteins; D014157:Transcription Factors; D005914:Globins