New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors.
A series of derivatives of 2,4- and 2,5-thiazolyl- or oxazolylbenzenesulphonamides has been prepared and evaluated as potential MMP inhibitors. The thiazole 15b have been found to exhibit MMP-2 and MMP-9 inhibitions higher than reference compounds GI 129471 and CGS 27023A.
Groupe de Recherches sur l'Inhibition de la Prolifération Cellulaire UPRES EA 2692, Equipe de Chimie Organique, Université des Sciences et Technologies de Lille, F-59655 Villeneuve d'Ascq, France.
Frédéric
F
Delbecq
Guy
G
Cordonnier
Nicole
N
Pommery
Didier
D
Barbry
Jean-Pierre
JP
Hénichart
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology*; D000096926:Benzenesulfonamides
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases; D011480:Protease Inhibitors; D013449:Sulfonamides; D000096926:Benzenesulfonamides