Protective effect of curcumin against lead neurotoxicity in rat.
Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective effect of curcumin against lead-induced neurotoxicity in rats. Exposure of rats to lead (50 mg/kg po) for 45 days caused an increase in lipid peroxidation (LPO) and a decrease in reduced glutathione (GSH) levels in cerebellum, corpus striatum, hippocampus and frontal cortex as compared with controls. Lead levels were significantly increased in these rats. Activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) decreased in all the brain regions following lead exposure. Interestingly, cotreatment with curcumin (100 mg/kg po) and lead (50 mg/kg po) for 45 days caused a significant decrease in LPO with concomitant decrease in lead levels in all the brain regions as compared with those treated with lead alone. A significant increase in reduced glutathione (GSH) levels, SOD and CAT activities was also observed in all the four brain regions in rats simultaneously treated with curcumin and lead. The results suggest that curcumin may prevent lead-induced neurotoxicity.
Shukla
Pradeep K
PK
Industrial Toxicology Research Centre, PO Box 80, MG Marg, Lucknow 226001, India.
Khanna
Vinay K
VK
Khan
Mohd Y
MY
Srimal
Rikhab C
RC
D000284:Administration, Oral; D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors / Q000737:chemistry; D002531:Cerebellum / Q000737:chemistry / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D003474:Curcumin / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D009044:Motor Cortex / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D020258:Neurotoxicity Syndromes / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000009:adverse effects* / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D013997:Time Factors; D014018:Tissue Distribution
D009942:Organometallic Compounds; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D003474:Curcumin; C008261:lead acetate