Gene mutation of thiopurine S-methyltransferase in Uygur Chinese.
OBJECTIVE
This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese.


METHODS
Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations-G238C, G460A and A719G.


RESULTS
One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively.


CONCLUSIONS
TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese.
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, 74 Zhongshan Road, Section 2, 510080 Guangzhou, P.R. China.
Jian-Ping
JP
Zhang
Yong-Yuan
YY
Guan
An-Long
AL
Xu
Shu-Feng
SF
Zhou
Jue-Heng
JH
Wu
Hong
H
Wei
Min
M
Huang
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D010597:Pharmacogenetics / Q000379:methods; D016133:Polymerase Chain Reaction / Q000379:methods; D044465:White People / Q000235:genetics*
D008780:Methyltransferases; C022745:thiopurine methyltransferase