Possible actions of tumor necrosis factor-alpha in ovarian function.
Tumor necrosis factor-alpha (TNFalpha) is a multifunctional cytokine that was first described as a tumoricidal factor produced by activated macrophages. Extensive research over the last two decades has suggested that TNFalpha has physiologically diverse actions in ovarian function in a variety of species. TNFalpha and its specific receptors are present in the ovaries of many species. Furthermore, TNFalpha plays multiple and probably important roles in corpus luteum (CL) function as well as ovarian cell function throughout the estrous cycle. This review focuses on recent studies documenting TNFalpha in ovarian follicles and CL in several mammals. In addition, possible roles of TNFalpha in ovarian function throughout the estrous cycle and in the gestation period are discussed.
Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences, Ibaraki 305-8602, Japan. sakumoto@affrc.go.jp
Ryosuke
R
Sakumoto
Kiyoshi
K
Okuda
D000818:Animals; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D006080:Ovarian Follicle / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha