Successful treatment of a critically ill patient with disseminated coccidioidomycosis, using adjunctive interferon-gamma.
Conventional antifungal therapy was not successful for a critically ill patient who had been hospitalized for 137 days in the intensive care unit with disseminated Coccidioides immitis infection and respiratory failure. The addition of interferon- gamma to the therapeutic regimen resulted in improvement and discharge from the hospital. Adjunctive interferon- gamma used in the successful treatment of severe coccidioidomycosis has not been reported previously.
Good Samaritan Hospital and Medical Center, Phoenix, Arizona, USA.
Timothy T
TT
Kuberski
Ronald J
RJ
Servi
Phillip J
PJ
Rubin
D000935:Antifungal Agents / Q000627:therapeutic use; D003047:Coccidioidomycosis / Q000188:drug therapy*; D003422:Critical Care; D016638:Critical Illness; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007371:Interferon-gamma / Q000627:therapeutic use*; D008875:Middle Aged
D000935:Antifungal Agents; D007371:Interferon-gamma