Subharmonic signal generation from contrast agents in simulated neovessels.
Detection and measurement of blood flow in neovessels around a tumor can yield prognostic information about the tumor. Early detection and classification may help differentiate benign and malignant tumors; thus, improving patient management. This can be accomplished by injecting ultrasonic contrast agents and measuring the backscattered signals from them. Use of the subharmonic backscattered signals from these agents may be better than fundamental or second harmonic components because of the negligible subharmonics generated by the surrounding tissue. Preliminary results on the detection and measurement of subharmonic signal components up to 12 dB (at increasing pressures) from very small tubes (200 to 300 microm diameter) are reported, demonstrating the possibility and potential application of subharmonic imaging in detecting tumor angiogenesis.
School of Biomedical Engineering, Sciences and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Govind
G
Bhagavatheeshwaran
William T
WT
Shi
Flemming
F
Forsberg
P M
PM
Shankar
D000418:Albumins; D001783:Blood Flow Velocity; D003287:Contrast Media; D005466:Fluorocarbons; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging*; D012542:Scattering, Radiation; D014463:Ultrasonography
D000418:Albumins; D003287:Contrast Media; C099458:FS 069; D005466:Fluorocarbons