Application of tetraoxadiaza-crown ether derivatives as chiral selector modifiers in capillary electrophoresis.
Two new diaza-crown ether derivatives (R-1, RS-1) have been synthesized from 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane and tested as potential chiral selectors in capillary electrophoresis (CE) for the chiral separation of five amino acid derivatives. The individual use of the selectors did not lead to chiral differentiation. However, they enhanced the enantioselective effect of different cyclodextrins in dual selector systems. In this paper, we report the effect of different substituted diaza-crown ether derivatives on the separation results obtained in dual systems with cyclodextrins.
Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, H-4010 Debrecen, Hungary.
Tímea
T
Iványi
Kornélia
K
Pál
István
I
Lázár
D Luc
DL
Massart
Yvan
Y
Vander Heyden
D000596:Amino Acids / Q000032:analysis / Q000302:isolation & purification; D043844:Crown Ethers / Q000138:chemical synthesis / Q000737:chemistry*; D003505:Cyclodextrins / Q000032:analysis; D004573:Electrolytes; D019075:Electrophoresis, Capillary / Q000379:methods*; D007202:Indicators and Reagents; D012015:Reference Standards; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000596:Amino Acids; D043844:Crown Ethers; D003505:Cyclodextrins; D004573:Electrolytes; D007202:Indicators and Reagents; D012996:Solutions