CYP2D6 genotypes and depressive symptoms during late pregnancy and postpartum.
The aim of this exploratory was to investigate the theory of a relation between cytochrome P450 2D6 (CYP2D6) genotype and depressive symptoms in late pregnancy and/or postpartum. We studied 145 women with depressive symptoms. CYP2D6 genotype was analysed in leukocyte DNA by polymerase chain reaction (PCR). There were no significant differences in CYP2D6 genotypes between the groups of women being depressed during and/or after pregnancy. The frequencies of CYP2D6 genotypes did not differ from other European studies. This study cannot confirm that depressive symptoms in late pregnancy and postpartum are connected with CYP2D6 genotype. It is, however, noteworthy that the frequency of ultrarapid metabolizers was higher than in a general Caucasian population. This warrants further exploration in a greater study sample, but should also be investigated in a general population with major depression.
Division of Obstetrics and Gynecology, Department of Molecular and Clinical Medicine, University Hospital, Lnköping, Sweden. ann.josefsson@lio.se
Ann
A
Josefsson
Gunilla
G
Sydsjö
Göran
G
Berg
Marja-Liisa
ML
Dahl
Mia
M
Wadelius
Conny
C
Nordin
D000328:Adult; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003863:Depression / Q000235:genetics*; D019052:Depression, Postpartum / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011248:Pregnancy Complications; D011263:Pregnancy Trimester, Third / Q000523:psychology*
D019389:Cytochrome P-450 CYP2D6