The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100.
Programme in Integrative Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
Denis
D
Reynaud
Dewi
D
Clark
Na
N
Qiao
Margaret L
ML
Rand
Cecil R
CR
Pace-Asciak
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003094:Collagen / Q000494:pharmacology; D006487:Hemostasis / Q000187:drug effects*; D006494:Heparin Antagonists / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D012016:Reference Values
D006494:Heparin Antagonists; C453725:PBT-3 compound; D000244:Adenosine Diphosphate; D003094:Collagen; D015126:8,11,14-Eicosatrienoic Acid