Assessment of heart rate variability in Boxers with arrhythmogenic right ventricular cardiomyopathy.
OBJECTIVE
To assess heart rate variability (HRV) in Boxers with arrhythmogenic right ventricular cardiomyopathy (ARVC), assess the ability of HRV analysis to identify differences in Boxers on the basis of severity of their arrhythmia, and evaluate the use of HRV to determine whether persistently high sympathetic tone is present in these dogs.


METHODS
Prospective study.


METHODS
24 Boxers with ARVC and 10 clinically normal non-Boxer dogs.


METHODS
Boxers were categorized as dogs with congestive heart failure (CHF), dogs with < or = 2 ventricular premature complexes (VPCs)/24 h (designated unaffected), or dogs with > 1,000 VPCs/24 h (designated affected). Ambulatory electrocardiography (24 hours) was performed in each dog. Recordings were analyzed for HRV variables at a commercial laboratory; differences in HRV variables among groups were compared with 1-way ANOVA.


RESULTS
Compared with control non-Boxer dogs and Boxers without CHF (affected and unaffected Boxers), HRV was reduced in Boxers with CHF. No differences in HRV variables were detected between affected and unaffected Boxers. Inconsistent differences were identified between the control dogs and Boxers without CHF that had various degrees of arrhythmias.


CONCLUSIONS
Results suggest that persistently high sympathetic tone is not a consistent feature of ARVC. Differences in some HRV variables between Boxers without CHF and control dogs suggest that Boxers may have different autonomic control of heart rate, compared with that of clinically normal non-Boxer dogs. The usefulness of HRV analysis appears limited to Boxers with ARVC that have systolic dysfunction and CHF.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Alan W
AW
Spier
Kathryn M
KM
Meurs
D000704:Analysis of Variance; D000818:Animals; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004285:Dogs; D015716:Electrocardiography, Ambulatory / Q000662:veterinary; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary; D006339:Heart Rate / Q000502:physiology*; D008297:Male; D011446:Prospective Studies; D013045:Species Specificity; D018879:Ventricular Premature Complexes / Q000175:diagnosis / Q000503:physiopathology / Q000662:veterinary