[Phenotypic changes in human bladder smooth muscle cell].
Tissue specimens were resected from 15 patients (age 7 to 82, average 52.2 years old) with bladder diseases; i.e., 2 with neurogenic bladder, 6 recipients of kidney transplantation with defunctionalized bladder, 3 with benign prostatic hypertrophy, 3 with bladder cancer and 1 with vesicoureteral reflux. We investigated the phenotypic expression of the bladder smooth muscle cells with bladder diseases. The ratio of non-contractile to contractile phenotypes (nc/c ratio) showed a rising tendency with aging. The increase of nc/c ratio was especially notable with neurogenic bladder. Phenotypic expression was observed in human bladder smooth muscle cells as reported in vascular smooth muscle cells. Several bladder diseases cause a conversion of contractile smooth muscle cell phenotype from contractile type to non-contractile type, and this modulation of smooth muscle cell phenotype may play an important role in detrusor function.
Department of Urology, Kinki University School of Medicine.
Seiji
S
Matsumoto
Tadashi
T
Hanai
Takashi
T
Kurita
Takahiro
T
Akiyama
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003285:Contractile Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000166:cytology*; D010641:Phenotype; D011470:Prostatic Hyperplasia / Q000473:pathology; D001743:Urinary Bladder / Q000166:cytology; D001745:Urinary Bladder Diseases / Q000235:genetics / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology; D001750:Urinary Bladder, Neurogenic / Q000473:pathology
D003285:Contractile Proteins