High-resolution dental magnetic resonance imaging of inferior alveolar nerve responses to the extraction of third molars.
The objective of this study was to assess whether signal changes can be detected in the neurovascular bundle of the mandibular canal after the extraction of a third molar. We retrospectively analyzed MRI scans of 30 test subjects with healthy mandibles and 41 patients who had had a wisdom tooth extracted. Signal intensities were measured at particular sites in the neurovascular bundle, which were defined as regions of interest (ROI) in the sagittal T1-weighted images before and after intravenous administration of a paramagnetic contrast agent. On the basis of the signal intensity increases that were measured after contrast agent administration, we compared the signal increases obtained for the patients who had received surgical treatment with the results obtained for the population of test subjects with unremarkable mandibles ( t-test, P<0.05). Compared with the healthy test subjects, patients who had received surgical treatment showed significantly higher signal intensity increases at two measurement sites, i.e., the second molar and the second premolar ( P<0.05). We found no significant differences when the measurements were performed at the first molar ( P=0.06), the third molar ( P=0.47) and in the area of the ascending mandibular ramus ( P=0.79). Compared with a population of healthy test subjects, patients who had their third molars surgically removed show higher signal intensity increases in the neurovascular bundle after intravenous contrast agent administration. The underlying cause may be the higher blood flow in the arteries and veins and the perineural plexus, which may give evidence of the pathophysiological mechanism of nerve damage in the narrow canal as a result of osteotomy.
Department of Neurology, Division of Neuroradiology, University of Heidelberg, Medical Center, 69120 Heidelberg, Germany. bodo_kress@med.uni-heidelberg.de
B
B
Kress
A
A
Gottschalk
L
L
Anders
C
C
Stippich
F
F
Palm
W
W
Bähren
K
K
Sartor
D000293:Adolescent; D000328:Adult; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008334:Mandible / Q000294:innervation* / Q000473:pathology; D008340:Mandibular Nerve / Q000502:physiology / Q000503:physiopathology*; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D011184:Postoperative Period; D012016:Reference Values; D012189:Retrospective Studies; D014081:Tooth Extraction
D003287:Contrast Media