Active or prior GB virus C infection does not protect against vertical transmission of HIV in coinfected women from Tanzania.
To determine whether GB virus C (GBV-C) infection is associated with protection against vertical transmission of human immunodeficiency virus (HIV), we tested 186 HIV-positive pregnant women for GBV-C. Neither active nor prior GBV-C infection was associated with a lower rate of HIV acquisition among infants. Thus, GBV-C does not appear to protect against perinatal HIV acquisition.
Weintrob
Amy C
AC
Duke University Medical Center, Durham, North Carolina 27710, USA. weint002@mc.duke.edu
Hamilton
John D
JD
Hahn
Christine
C
Klinzman
Donna
D
Moyo
Gustav
G
Zdunek
Dietmar
D
Hess
Georg
G
Benjamin
Daniel K
DK
Stapleton
Jack T
JT
D000328:Adult; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications*; D029407:GB virus C; D015658:HIV Infections / Q000150:complications / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D013636:Tanzania