[Major role of stromal cell derived factor and its receptor CXCR4 in the mobilization and homing of hematopoietic stem/progenitor cells - review].
Stromal cell derived factor (SDF), expressing on bone marrow stromal cells is a CXC-type chemokine, which specifically chemoattracts hematopoietic stem cells (HSCs) expressing CXCR4. SDF plays important roles in homing and mobilizing of HSCs. In this paper the regulatory mechanism of SDF/CXCR4 in the HSC migration process is mainly reviewed.
Wang
Cheng-Yan
CY
The State Key Laboratory of Biomembrane and Membrane biotechnology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.
Miao
Zhen-Chuan
ZC
Feng
Mei-Fu
MF
D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000502:physiology*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D019718:Receptors, CXCR4 / Q000502:physiology*; D015398:Signal Transduction
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019718:Receptors, CXCR4