[Study on the pharmacokinetics and bioavailability of syringic acid in rabbits].
OBJECTIVE
To study the pharmacokinetics and bioavailability of syringic acid(SA) in rabbits by HPLC.


METHODS
After the rabbits were injected SA injection via ear vein and peritoneal cavity, blood was collected also via ear vein at different time-point. Then the concentration of SA in blood was determined by HPLC and the concentration-time curve was mapped to simulate a compartment model. So the pharmacokinetic parameters were calculated out. Several days after this injection, the drug was administered to the rabbits via i.p. and using the same method, another concentration-time curve was obtained. By comparing the AUC of the two curves, bioavailability was obtained.


RESULTS
The concentration-time curve of SA in rabbits after i.v. fitted in a two-compartment open model and the absolute bioavailability was 86.27%.


CONCLUSIONS
The results were valuable for the clinical application of new anti-endotoxic drug from Radix Isatidis.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030.
Yunhai
Y
Liu
Xianxi
X
Guo
Zhengsong
Z
Lü
Wei
W
Xie
D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005260:Female; D005707:Gallic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D031219:Isatis / Q000737:chemistry*; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D005707:Gallic Acid; C001945:syringic acid