Serum sickness-like reaction associated with griseofulvin.
OBJECTIVE
To describe a serum sickness-like reaction associated with griseofulvin in a child being treated for tinea capitis.


METHODS
A previously healthy 5-year-old boy presented with tactile fever, rash on his legs and back, swelling of his toes and fingers, and leg pain. He was being treated at the time with griseofulvin for tinea capitis. Laboratory evaluation including immunologic workup revealed no abnormalities. Replacement of griseofulvin with itraconazole, along with an antihistamine and a nonsteroidal antiinflammatory drug, led to complete resolution of the patient's symptoms. An objective causality assessment revealed that the adverse reaction was probable.


CONCLUSIONS
Serum sickness-like reactions may occur 7-21 days following exposure to an offending agent. Clinical manifestations are similar to those of serum sickness, with fever, malaise, and cutaneous eruption. However, on laboratory workup, complement levels are normal. Management of serum sickness-like reaction includes replacing the offending agent and providing symptomatic relief.


CONCLUSIONS
Clinicians should be aware of the possibility of serum sickness-like reaction associated with griseofulvin therapy and consider the possibility when choosing between griseofulvin and newer, more expensive drugs.
Department of Pediatrics E, Schneider Children's Medical Center, Petah Tiqva, Israel. colton@netvision.net.il
Roberta L
RL
Colton
Jacob
J
Amir
Marc
M
Mimouni
Avraham
A
Zeharia
D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D006118:Griseofulvin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012713:Serum Sickness / Q000139:chemically induced*; D014006:Tinea Capitis / Q000188:drug therapy
D000935:Antifungal Agents; D006118:Griseofulvin