[Expression of CD44v6 and E-cadherin in prostate carcinoma and metastasis of prostate carcinoma].
OBJECTIVE
To study the expression of CD44v6 and E-cadherin(ED) in prostate carcinoma in relation to the metastasis of prostate carcinoma.


METHODS
The expression of CD44v6 and ED in 45 cases of prostate carcinoma was studied with immunohistochemical technique.


RESULTS
The positive expression rates of CD44v6 and ED in prostate carcinoma were 77.8% and 48.9%, respectively. The high level expression of CD44v6 and the low level expression of ED were positively correlated with differentiation, clinical staging and metastasis of prostate carcinoma (P < 0.05). The expression of CD44v6 was negatively correlated with ED(r = -0.58, P < 0.005).


CONCLUSIONS
The expression of CD44v6 and ED protein might be a useful marker for prostate carcinoma in evaluating the biological behavior and prognosis of the tumor.
Gu
Huaping
H
Department of Pathology, 251st Hospital of PLA, Zhangjiakou, Hebei 075000, China. guhuapingzjk@sohu.com
Shang
Peizhong
P
Zhou
Cuiling
C
D015820:Cadherins / Q000032:analysis*; D002454:Cell Differentiation; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D008297:Male; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000737:chemistry* / Q000473:pathology
C112697:CD44v6 antigen; D015820:Cadherins; D006023:Glycoproteins; D018960:Hyaluronan Receptors