Synthesis of new N-substituted cyclic imides with an expected anxiolytic activity. XXII. Derivatives of 1-methoxy-5-bicyclo[2.2.2]-oct-5-one-2,3-dicarboximide.
Continuing our studies with the design of new anxiolytics we have now synthesized a series of new compounds, derivatives of 1-methoxybicyclo[2.2.2]-oct-5-one-2,3-dicarboximide bearing a 4-aryl-1-piperazinylbutyl group attached to the imide nitrogen.
Kossakowski
Jerzy
J
Department of Medical Chemistry, The Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, Poland.
Jarocka-Wierzba
Monika
M
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
C484801:1-methoxy-5-bicyclo(2.2.2)-oct-5-one-2,3-dicarboximide; D014151:Anti-Anxiety Agents; D001643:Bridged Bicyclo Compounds; D007094:Imides