Transient hypogonadotrophic hypogonadism in males with acute toxoplasmosis: suppressive effect of interleukin-1 beta on the secretion of GnRH.
BACKGROUND
In September 2002, an outbreak of toxoplasmosis was noted in a male boarding high school on the Aegean coast of Turkey. We have focused our efforts to investigate the sex hormones in this population.


METHODS
Blood samples were collected from 40 male patients, 17-18 years old, who also had positive titres of antibody to Toxoplasma gondii. Serum FSH, LH, free testosterone (FT), total testosterone (TT), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta) and macrophage-inflammatory protein-1alpha (MIP-1alpha) concentrations were measured in all patients and 20 control subjects. Initially, the patients were divided on the basis of the levels of sex hormones into the following groups: patients who had normal sex hormone levels (n = 31) as group A and patients with low sex hormone levels (n = 9) as group B.


RESULTS
IL-1beta levels were found to be higher in group B patients than group A. The levels of IL-1beta correlated significantly in a negative manner with FSH, LH, FT and TT in all patients with acute toxoplasmosis (n = 40).


CONCLUSIONS
Acute toxoplasma infection may cause temporary hypogonadotrophic gonadal insufficiency regardless of the course of the disease.
Departments of Internal Medicine, Gulhane Military Medical Academy, TR-06018 Etlik-Ankara, Turkey. coktenli@ttnet.net.tr
Cagatay
C
Oktenli
Levent
L
Doganci
Taner
T
Ozgurtas
R Engin
RE
Araz
Mehmet
M
Tanyuksel
Ugur
U
Musabak
S Yavuz
SY
Sanisoglu
Zeki
Z
Yesilova
M Kemal
MK
Erbil
Ali
A
Inal
D000208:Acute Disease; D000293:Adolescent; D016022:Case-Control Studies; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D007006:Hypogonadism / Q000469:parasitology*; D007375:Interleukin-1 / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D014123:Toxoplasmosis / Q000097:blood / Q000150:complications* / Q000378:metabolism*
D007375:Interleukin-1; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone