Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy.
In this study, we used spectral analysis to assess changes in respiratory recording variability during infusion of L-arginine and vitamin C, individually or together, in patients with chronic heart failure. We found that healthy subjects have a substantial ability to modulate sympathetic-mediated peripheral vascular resistance through endothelial synthesis of nitric oxide. Patients with chronic heart failure lose this ability.
Piccirillo
Gianfranco
G
Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università La Sapienza, Rome, Italy. gianfranco.piccirillo@uniroma1.it
Raffaele
Quaglione
Q
Fimognari
Filippo
F
Moisè
Antonio
A
Mario
Malavasi
M
Lionetti
Marco
M
Naso
Camilla
C
Di Carlo
Silvia
S
Nocco
Marialuce
M
Magrì
Damiano
D
D000465:Algorithms; D000975:Antioxidants / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000503:physiopathology*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D012119:Respiration / Q000187:drug effects*; D012815:Signal Processing, Computer-Assisted; D016037:Single-Blind Method; D014655:Vascular Resistance / Q000187:drug effects
D000975:Antioxidants; D001120:Arginine; D001205:Ascorbic Acid