Suppression of longitudinal increase in CSF F2-isoprostanes in Alzheimer's disease.
We report the first longitudinal analysis of cerebrospinal fluid (CSF) F2-isoprostanes (IsoPs), quantitative in vivo biomarkers of lipid peroxidation, in patients with mild Alzheimer's disease (AD). CSF F2-IsoPs (i) were significantly increased in patients followed over one year, (ii) correlated with some clinical indices of dementia following correction for variation in ventricular enlargement, and (iii) were significantly lower in patients who used both alpha-tocopherol and vitamin C.
Quinn
Joseph F
JF
Department Neurology, Oregon Health and Sciences University, Portland, OR, USA.
Montine
Kathleen S
KS
Moore
Milar
M
Morrow
Jason D
JD
Kaye
Jeffrey A
JA
Montine
Thomas J
TJ
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy; D000975:Antioxidants / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002552:Cerebral Ventricles / Q000473:pathology; D018450:Disease Progression; D028441:F2-Isoprostanes / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D013223:Statistics as Topic; D024502:alpha-Tocopherol / Q000008:administration & dosage; D016875:tau Proteins / Q000134:cerebrospinal fluid
D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D016875:tau Proteins; D024502:alpha-Tocopherol; D001205:Ascorbic Acid