[Effect of early post-resuscitation endotoxemia on the myocardial function].
The impact made by serum (which was obtained in 30 minutes after resuscitation) on the cardiovascular system was studied in experiments with the total body as well as with isolated and isovolumetrically contracting hearts of white outbred male rats. A 5-minute clinical death was provoked by a severe blood loss. The "toxic" serum, when administered to the intact animals with the macrophage system blocked by trypan blue, was found to reduce the stroke and minute hearts volumes and to increase the general resistance of peripheral vessels. Lower force and velocity indices of the myocardium contractility, a higher consumption of glucose by the heart per a unit of a performed function, disassociation of the oxidation phosphorylation, activation of anaerobic glycolysis and increased discharges of cardiachystiocyte, lactate, pyruvate and of enzymes of different ultrasound localizations were detected in perfusion of the hearts isolated by Krebs-Henzelight solution containing the "toxic" serum.
Zolotov
A N
AN
Shikunova
L G
LG
Dolgikh
V T
VT
Lukach
V N
VN
Girsh
A O
AO
D000818:Animals; D016887:Cardiopulmonary Resuscitation; D019446:Endotoxemia / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D004731:Endotoxins / Q000097:blood; D006323:Heart Arrest / Q000150:complications / Q000628:therapy; D006439:Hemodynamics / Q000502:physiology*; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D014343:Trypan Blue / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000502:physiology*
D004731:Endotoxins; D014343:Trypan Blue