[Effect of xanthnotoxol on contraction of rabbit thoracic aortic strips].
OBJECTIVE
To study the effect of xanthnotoxol (XT) on contractility of rabbit thoracic aorta strips and its relationship with Ca2+.


METHODS
Routine experimental methods for isolated thoracic aorta strips were adopted.


RESULTS
XT and verapamil (Ver) can make the dose-response curve of rabbit thoracic aorta strips induced by NE, KCl, CaCl2 shifed right (the pD'2 of KCl and CaCl2 value was 3.58 +/- 0.07 and 4.12 +/- 0.12) and depressed the maximal responses. Like verapamil (Ver), it is accomplished by calcium antagonism. XT could selectively block the voltage dependence calcium channel (VDC), and have no effect on the receptor operated calcium channel (ROC).


CONCLUSIONS
It suggested XT had selectly blocking effect on voltage dependence calcium channel.
Gannan Medical College, Ganzhou 341000.
Jing
J
Zeng
Qishen
Q
Lian
Qing
Q
Zhou
Li
L
Zhou
Heyang
H
Ye
Xianhua
X
Huang
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D019661:Apiaceae / Q000737:chemistry; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D011564:Furocoumarins / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; C021768:xanthotoxol; D014700:Verapamil; D002118:Calcium