Molecular interaction maps--a diagrammatic graphical language for bioregulatory networks.
Molecular interaction maps (MIMs) use a clear, accurate, and versatile graphical language to depict complex biological processes. Here, we discuss the main features of the MIM language and its potential uses. MIMs can be used as database resources and simulation guides, and can serve to generate new hypotheses regarding the roles of specific molecules in the bioregulatory networks that control progression through the cell cycle, differentiation, and cell death.
Aladjem
Mirit I
MI
Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. aladjemm@mail.nih.gov
Pasa
Stefania
S
Parodi
Silvio
S
Weinstein
John N
JN
Pommier
Yves
Y
Kohn
Kurt W
KW
D000818:Animals; D019295:Computational Biology / Q000379:methods* / Q000706:statistics & numerical data*; D003196:Computer Graphics; D030562:Databases, Protein; D005786:Gene Expression Regulation / Q000235:genetics*; D025941:Protein Interaction Mapping / Q000379:methods*; D015398:Signal Transduction / Q000235:genetics*