Rediocides B-E, potent insecticides from Trigonostemon reidioides.
Four new congeners, rediocides B-E (2-5), of the previously reported rediocide A (1) were isolated from a methanol extract of the roots of the plant Trigonostemon reidioides. The structures of these minor analogues were elucidated by comparison of their NMR and mass spectral data with those of rediocide A and confirmed by extensive 2D NMR spectral analysis. They all possess potent activity against fleas (Ctenocephalides felis) in an artificial membrane feeding system and exhibited LD(90) values ranging from 0.25 to 0.5 ppm.
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. hiranthi_jayasuriya@merck.com
Hiranthi
H
Jayasuriya
Deborah L
DL
Zink
Robert P
RP
Borris
Weerachai
W
Nanakorn
Hans T
HT
Beck
Michael J
MJ
Balick
Michael A
MA
Goetz
Lynn
L
Gregory
Wesley L
WL
Shoop
Sheo B
SB
Singh
D000818:Animals; D009033:Culicidae; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D018942:Macrolides; D008567:Membranes, Artificial; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D005423:Siphonaptera; D013237:Stereoisomerism; D013785:Thailand
D004224:Diterpenes; D007306:Insecticides; D018942:Macrolides; D008567:Membranes, Artificial; C483695:rediocide A