Plasma and cerebrospinal fluid amino acids in epileptic patients.
Altered plasma and cerebrospinal fluid amino acid levels may be associated with human epilepsy. We studied three groups of patients, those with a generalized epileptic syndrome, juvenile myoclonic epilepsy, patients with refractory localization-related epilepsies, and patients with acute seizures (within 24 h). Plasma levels of amino acids were studied in all patient groups, as were those in the cerebrospinal fluid (CSF) of patients with acute seizures. After acute seizures, the amino acid changes in the CSF were limited to a reduction in the level of taurine, whereas the levels of most amino acids in plasma were decreased. On the other hand, levels of the excitatory amino acids glutamate and aspartate were increased. The most notable finding in the juvenile myoclonic epilepsy patients was an increase in glutamate level in the plasma. Our study supports the conception of an altered metabolism of glutamate in generalized epilepsies.
Rainesalo
Sirpa
S
Brain Research Center, Medical School, University of Tampere, Finland. sirpa.rainesalo@pshp.fi
Keränen
Tapani
T
Palmio
Johanna
J
Peltola
Jukka
J
Oja
Simo S
SS
Saransaari
Pirjo
P
D000328:Adult; D000596:Amino Acids / Q000097:blood* / Q000134:cerebrospinal fluid*; D004827:Epilepsy / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000596:Amino Acids