[Relationship between polymorphisms of cystathionine beta-synthase gene and stroke].
OBJECTIVE
To determine whether the T27796C mutation in cystathionine beta-synthase (CBS) gene is associated with stroke in Chinese.


METHODS
The T27796C mutation in CBS gene of 59 cases with stroke and 65 health controls were detected by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP).


RESULTS
As this investigation shown, the frequencies of two alleles of T27796C mutation were followed: C was 56.8%, T was 43.2% in cases and C was 51.5%, T was 48.5% in controls. T27796C mutation had no obvious relativity to the stroke (P>0.05). There was no significant difference in frequency of alleles of this mutation between cases and controls (CC: 35.6% vs. 24.6%; CT: 42.4% vs. 53.8%; TT: 22.0% vs. 21.5%; all P>0.05). There was not obvious difference in frequency of alleles of this mutation between hemorrhagic patients and ischemic stroke patients (all P>0.05).


CONCLUSIONS
T27796C mutation in CBS is not obviously correlated with stroke and this mutation is not associated with categories of stroke.
Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130031, Jilin, China.
Le
L
Fang
Wei
W
Wu
Ying-quan
YQ
Wu
D000328:Adult; D000483:Alleles; D002681:China; D003541:Cystathionine beta-Synthase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020521:Stroke / Q000201:enzymology / Q000235:genetics*
D003541:Cystathionine beta-Synthase