Immune activation and depression in women with rheumatoid arthritis.
OBJECTIVE
We examined markers of immune activation during periods of stress and depressive symptoms in 45 female patients with rheumatoid arthritis (RA) in comparison to 106 controls with no autoimmune disease.


METHODS
Depressive symptoms were recorded, clinician ratings of disease activity were made, and blood was drawn for RA patients and controls at baseline and during a designated stressful week.


RESULTS
Counts of T cell subpopulations revealed significant differences between RA and control groups in proportions of CD8 and CD4 cells, with higher CD4 and lower CD8 counts for the RA participants. Significant depression by diagnosis interactions were found, revealing greater CD4 activation among RA patients who were depressed in comparison to other groups. Only marginally significant effects of stress were found on T cell counts. Interleukin 6 (IL-6) concentrations also differentiated groups, with the highest levels of IL-6 observed for depressed RA patients under stress.


CONCLUSIONS
These findings provide new evidence that psychosocial factors play a significant role in autoimmune processes that underlie RA.
Department of Rheumatology, Arizona State University, Tempe, Arizona 85287, USA. alex.zautra@asu.edu
Alex J
AJ
Zautra
David C
DC
Yocum
Isidro
I
Villanueva
Bruce
B
Smith
Mary C
MC
Davis
Jeanne
J
Attrep
Michael
M
Irwin
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000523:psychology*; D015415:Biomarkers; D003863:Depression / Q000276:immunology*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D008875:Middle Aged; D013315:Stress, Psychological / Q000276:immunology*
D015415:Biomarkers; D015850:Interleukin-6