[New materials suitable for implantation--preparation for implants].
OBJECTIVE
Connective tissue components, particularly collagen and proteoglycan, stimulate cell proliferation and thus promote tissue regeneration. This fact was utilized to test some new implant materials, which were covered by these components, for the speed and quality of their encapsulation.


METHODS
The materials tested included polyethylene (PE) with either a hydrophobic (HPHO) or a hydrophilic (HPHI) surface and the C-C composite. Before implantation in experimental animals, the materials were coated with a thin layer of collagen-proteoglycan copolymer.


METHODS
Collagen was obtained from calf hide (ISC 40 fraction) and proteoglycan was isolated from calf cartilage with 2M GuHCl. The concentrations of elements in implant materials were assessed by the method of ESCA photoelectron spectroscopy (electron spectroscopy for chemical analysis) and, using a comparison of the values of electron binding energies at inner levels with the published ones, the chemical states of elements were identified.


RESULTS
Carbon, oxygen and silicon were identified on the surface of the PE HPHI sample; carbon, oxygen, calcium, manganese and sulfur were found on the PE HPHO sample and nitrogen, oxygen and fluorine were present on the C-C composite.


CONCLUSIONS
In our group of patients there was a small rate of rheumatoid arthritis, while in most literature these patients are predominant. In accordance with the outcomes of other authors, ASS is fraught with recurrence. ASS does not strike to fibrous capsule, like an open surgery synovectomy, and from these islands synovialis could regenerate.


CONCLUSIONS
The presence of manganese and calcium on the surfaces of the materials investigated indicates the existence of a collagen-proteoglycan copolymer, which contains NH2 and COO groups derived from collagen and SO4 groups from proteoglycan. It is necessary to verify this theoretical assumption based on measurement data in a biological experiment.
Revmatologický ústav, Praha.
M
M
Adam
M
M
Petrtýl
K
K
Balík
Z
Z
Bastl
D000818:Animals; D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D003094:Collagen; D008422:Materials Testing; D020959:Polyethylene; D019736:Prostheses and Implants; D011509:Proteoglycans
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D011509:Proteoglycans; D020959:Polyethylene; D003094:Collagen