Predilection of the macular region to high incidence of choroidal neovascularization after intense laser photocoagulation in the monkey.
OBJECTIVE
To determine the key factors for creating a high incidence model of choroidal neovascularization (CNV) in the monkey.


METHODS
Intense laser photocoagulation was performed in 8 eyes of 4 monkeys using krypton red and green-yellow and Alcon frequency-doubled diode ophthalmic lasers. Eight to 13 lesions were delivered to an area between the temporal vascular arcades in each eye. Development of CNV was monitored by fluorescein angiography at 2 and 4 weeks after laser treatment, and the results were correlated with histological analysis.


RESULTS
A much higher incidence of CNV occurred in the macular region, which refers to an anatomic area equivalent to a mean +/- SD 2.5 +/- 0.4 times the horizontal diameter of the optic disc in the fundus. Regardless of the type of ophthalmic laser used, 72% of lesions developed fluorescein leakage within the macula, compared with 12% outside the macula (P<.001). By histological analysis, 89% of lesions developed microscopic CNV within the macula vs 22% outside the macula (P<.001).


CONCLUSIONS
The macular region is predisposed to creation of laser-induced CNV in the monkey.Clinical Relevance The predilection of the macular region to a high incidence of laser-induced CNV may account for the high recurrence rate of subfoveal CNV after laser treatment in humans.
Shen
Wei-Yong
WY
Department of Molecular Ophthalmology, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands.
Lee
Shu Yen
SY
Yeo
Ian
I
Lai
Chooi-May
CM
Mathur
Ranjana
R
Tan
Donald
D
Constable
Ian J
IJ
Rakoczy
P Elizabeth
PE
D000818:Animals; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology*; D005451:Fluorescein Angiography; D015994:Incidence; D017075:Laser Coagulation / Q000009:adverse effects*; D008252:Macaca fascicularis; D008266:Macula Lutea / Q000473:pathology*; D012008:Recurrence