Accurate dose calibrator activity measurement of 90Y-ibritumomab tiuxetan.
This investigation examined the accuracy of dose calibrator activity measurement of the beta-emitting radiopharmaceutical (90)Y-ibritumomab tiuxetan.


METHODS
Five different facilities independently measured (90)Y in a 10-mL syringe geometry with 30 dose calibrator models from 3 different manufacturers. The activities ranged from 81.4 MBq (2.2 mCi) to 1,406 MBq (38 mCi) over the volume range of 3-9 mL.


RESULTS
The mean dial settings for (90)Y measurement were 375, 51 x 10, and 897 x 100 for Atomlab, CRC, and Mark V dose calibrators, respectively. The maximum volume dependence was 0.28%/mL.


CONCLUSIONS
This study demonstrated that when measuring all volumes of (90)Y-ibritumomab tiuxetan activity prescriptions, only a single dial setting for a given manufacturer's dose calibrator is required for accurate measurements. Volume corrections are not necessary. For best accuracy, an individually determined dial value should be used.
Nuclear Physics Enterprises, Wellington, Florida 33414, USA. siegelja@aol.com
Jeffry A
JA
Siegel
Brian E
BE
Zimmerman
Kory
K
Kodimer
Mary A
MA
Dell
William E
WE
Simon
D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000627:therapeutic use; D001610:Beta Particles; D002138:Calibration / Q000592:standards*; D019544:Equipment Failure Analysis / Q000379:methods*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy; D015337:Multicenter Studies as Topic; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods / Q000592:standards*; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods / Q000592:standards*; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014481:United States
D000911:Antibodies, Monoclonal; C422802:ibritumomab tiuxetan