Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota.
Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document temporal changes in the diversity of fecal bacteria of a patient who developed AAD. Antibiotic administration was associated with distinct changes in the diversity of the gut microbiota, including a marked decrease in the prevalence of butyrate-producing bacteria. Following the discontinuation of the antibiotic, resolution of diarrhea was accompanied by a reversal of these changes, providing the first direct evidence linking changes in the community structure of the gastrointestinal bacteria with the development of AAD.
Young
Vincent B
VB
Department of Microbiology and Molecular Genetics, Infectious Diseases Unit, National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA. youngvi@msu.edu
Schmidt
Thomas M
TM
D000208:Acute Disease; D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001419:Bacteria / Q000145:classification / Q000187:drug effects / Q000254:growth & development / Q000302:isolation & purification; D019818:Clavulanic Acid / Q000009:adverse effects*; D004275:DNA, Ribosomal / Q000235:genetics; D003967:Diarrhea / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005243:Feces / Q000382:microbiology*; D006801:Humans; D008297:Male; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000379:methods; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012852:Sinusitis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S; D019818:Clavulanic Acid; D000658:Amoxicillin