Molecular mechanisms of learning and memory.
Memory is the process by which organisms are able to record their experiences, and use this information to adapt their responses to the environment. As such, it is vital for survival. In recent years, the development of spatially and temporally selective techniques for the regulation of gene expression has allowed the molecular details of this process to emerge. Here we review the molecular mechanisms thought to underlie memory acquisition and storage, as well as discuss recent evidence regarding the mechanisms of subsequent memory consolidation.
Dunning
Jane
J
Department of Molecular Medicine and Pathology, University of Auckland, Auckland 1001, New Zealand. j.dunning@auckland.ac.nz
During
Matthew J
MJ
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D008959:Models, Neurological; D013569:Synapses / Q000502:physiology; D019076:Transgenes
D017868:Cyclic AMP-Dependent Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases