A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity.
A series of novel heterocyclic analogues have been synthesized and evaluated for their ability to inhibit phenylalanyl-t-RNA synthetases and act as antibacterial agents. Several analogues have good antibacterial activity against Staphylococcus aureus.
Yu
Xiang Y
XY
Department of Medicinal Chemistry, Cubist Pharmaceuticals Inc., 24 Emily Street, Cambridge, MA 02139, USA. xyu@activbiotics.com
Finn
John
J
Hill
Jason M
JM
Wang
Zhong G
ZG
Keith
Dennis
D
Silverman
Jared
J
Oliver
N
N
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D010652:Phenylalanine-tRNA Ligase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D010652:Phenylalanine-tRNA Ligase