Severe hypertension and massive proteinuria in a newborn with renal artery stenosis.
Renal vein thrombosis and the congenital nephrotic syndrome have been associated with nephrotic-range proteinuria/nephrotic syndrome and hypertension in the newborn period. We describe a newborn with severe hypertension and proteinuria secondary to unilateral renal artery stenosis. Proteinuria completely disappeared with blood pressure control (with sodium nitroprusside and an angiotensin-converting enzyme inhibitor). Although renin was not measured, we speculate that proteinuria might have been induced by a high renin state, and was controlled by the angiotensin-converting enzyme inhibitor.
Cachat
François
F
Department of Pediatrics, Division of Pediatric Nephrology, University Hospital, Lausanne, Switzerland. Francois.Cachat@hospvd.ch
Bogaru
Alina
A
Micheli
Jean-Leopold
JL
Lepori
Domenico
D
Guignard
Jean-Pierre
JP
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000627:therapeutic use; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D006978:Hypertension, Renovascular / Q000151:congenital / Q000209:etiology*; D007231:Infant, Newborn; D007741:Labetalol / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D009599:Nitroprusside / Q000627:therapeutic use; D011507:Proteinuria / Q000151:congenital / Q000209:etiology*; D011859:Radiography; D012078:Renal Artery Obstruction / Q000150:complications* / Q000151:congenital
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics; D009599:Nitroprusside; D006830:Hydralazine; D005665:Furosemide; D002216:Captopril; D007741:Labetalol