Neurological disease: listening to gene silencers.
Neurons regulate the expression of genes essential to individual neuron function through elegant combinatorial interactions among a limited number of transcription factors. In addition, an economy of regulatory control is practiced within the nucleus that belies conceptual divisions of transcription factors into "repressors" and "activators." Studies of the neural restrictive silencer element (NRSE, also known as RE1) and its repressor protein have revealed a multitude of mechanisms by which transcriptional regulation is not only elaborated in normal neuronal development, but perverted in disease states.
Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.
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Roopra
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Huang
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Dingledine
D000818:Animals; D005786:Gene Expression Regulation; D020868:Gene Silencing; D016153:Genes, Suppressor; D006801:Humans; D008954:Models, Biological; D009422:Nervous System Diseases / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors