Rediocides B-E, potent insecticides from Trigonostemon reidioides.
Four new congeners, rediocides B-E (2-5), of the previously reported rediocide A (1) were isolated from a methanol extract of the roots of the plant Trigonostemon reidioides. The structures of these minor analogues were elucidated by comparison of their NMR and mass spectral data with those of rediocide A and confirmed by extensive 2D NMR spectral analysis. They all possess potent activity against fleas (Ctenocephalides felis) in an artificial membrane feeding system and exhibited LD(90) values ranging from 0.25 to 0.5 ppm.
Jayasuriya
Hiranthi
H
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. hiranthi_jayasuriya@merck.com
Zink
Deborah L
DL
Borris
Robert P
RP
Nanakorn
Weerachai
W
Beck
Hans T
HT
Balick
Michael J
MJ
Goetz
Michael A
MA
Gregory
Lynn
L
Shoop
Wesley L
WL
Singh
Sheo B
SB
D000818:Animals; D009033:Culicidae; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D018942:Macrolides; D008567:Membranes, Artificial; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D005423:Siphonaptera; D013237:Stereoisomerism; D013785:Thailand
D004224:Diterpenes; D007306:Insecticides; D018942:Macrolides; D008567:Membranes, Artificial; C483695:rediocide A