The role of CD44v3 expression in female breast carcinomas.
CD44-protein and its isoforms are the multifunctional cell adhesion molecules participating in cell-cell and cell-matrix interactions. In this study we estimated the frequency of CD44-expression as well as two of its variants (CD44v3 and CD44v5) in female breast cancer. Among 75 breast carcinomas studied, 23 (44.2%) presented strong membrane reaction with monoclonal antibody against antigen CD44. The immunocytochemical reaction to CD44v3 and CD44v5 were observed in 16 (21.3%) and 50 (66.75%) cases, respectively. The presence of CD44v3 antigen on the surface of breast cancer cells significantly correlated with ER expression (0.0430) and the lack of p53 protein (p=0.0252), and also with the percentage of T cells in the total population of lymphocytes infiltrating the primary tumor (TILs) (p=0.0248). What is more important, the reaction to CDv3 significantly correlated with the presence of metastases to the lymph nodes (p=0.0385).
Department of Tumour Pathology, Oncology Center, Kraków.
Janusz
J
Ryś
Anna
A
Kruczak
Bozena
B
Lackowska
Agnieszka
A
Jaszcz-Gruchała
Anna
A
Brandys
Andrzej
A
Stelmach
Marian
M
Reinfuss
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008207:Lymphatic Metastasis / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor; C121450:CD44V3,8-10; C113800:CD44v5 antigen; D018960:Hyaluronan Receptors