Sarcoid polyneuropathy responsive to intravenous immunoglobulin.
We describe a 38-year-old woman with a predominantly sensory axonal polyneuropathy in whom a nerve biopsy demonstrated sarcoid granulomas. The neuropathy did not respond to oral steroid therapy but there was a rapid and repeated response to intravenous immunoglobulin, which gradually diminished over subsequent treatments, but remained beneficial. The systemic sarcoidosis remained active.
Department of Neurology, Royal London Hospital, Whitechapel, London E1 1BB, UK.
Dominic
D
Heaney
Jennian F
JF
Geddes
Kulan
K
Nagendren
Michael
M
Swash
D000328:Adult; D018771:Arthralgia / Q000209:etiology / Q000473:pathology; D001706:Biopsy; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000473:pathology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D009431:Neural Conduction / Q000502:physiology; D010292:Paresthesia / Q000209:etiology / Q000473:pathology / Q000628:therapy; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications*; D013497:Sural Nerve / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome; D014605:Uveitis / Q000209:etiology / Q000473:pathology
D016756:Immunoglobulins, Intravenous