First molecular identification of human Dobrava virus infection in central Europe.
Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava hantavirus (DOBV). This is the first molecular identification of human infection by DOBV in central Europe and the first proof that a virus strain related to the DOBV-Aa lineage, carried by Apodemus agrarius rodents, is able to cause HFRS.
Klempa
Boris
B
Institute of Virology, University Hospital Charité, D-10098 Berlin, Germany.
Schütt
Morten
M
Auste
Brita
B
Labuda
Milan
M
Ulrich
Rainer
R
Meisel
Helga
H
Krüger
Detlev H
DH
D000328:Adult; D000818:Animals; D005858:Germany; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000175:diagnosis* / Q000635:transmission; D006474:Hemorrhagic Disorders / Q000150:complications / Q000821:virology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D009115:Muridae / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D012367:RNA, Viral