CSF soluble Fas correlates with the severity of HIV-associated dementia.
Soluble Fas (sFas) and soluble Fas ligand (sFasL) are associated with cellular dysfunction and death and are elevated in CSF from patients with HIV dementia (HIV-D). The authors investigated whether these markers correlated with dementia severity and course. sFas and sFasL were measured in 15 highly active antiretroviral therapy (HAART)-naïve HIV-D subjects, 30 HAART-naïve HIV+ controls, and 17 HIV-controls. HIV-D subjects had higher CSF sFas levels than controls. Subjects with moderate/severe dementia had higher CSF sFas levels than those with mild dementia. CSF sFas trended lower in those with progressive dementia.
Towfighi
A
A
Department of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Skolasky
R L
RL
St  Hillaire
C
C
Conant
K
K
McArthur
J C
JC
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000473:pathology; D000328:Adult; D017209:Apoptosis; D001253:Astrocytes / Q000473:pathology; D018450:Disease Progression; D053222:Fas Ligand Protein; D005260:Female; D015658:HIV Infections / Q000134:cerebrospinal fluid / Q000523:psychology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012995:Solubility; D019014:fas Receptor / Q000134:cerebrospinal fluid*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor