Development of post-weaning diarrhoea in piglets. Relation to presence of Escherichia coli strains and rotavirus.
Weaning of piglets complicated with an exposure to pathogenic strains of Escherichia coli was scrutinized in two sets. The first set comprised 20 animals representing two litters and the second set included 30 animals from five litters. The piglets were either left as controls or exposed to one or three pathogenic strains of E. coli. Aiming to simulate a natural exposure the challenge strains were spread on the floor of the pens at weaning. In addition the pigs experienced several non-infectious stress factors commonly occurring at that occasion. Some groups were given adrenocorticotropic hormone (ACTH), aiming to simulate a stressful weaning. The balance and the composition of the faecal coliform populations, measured by a metabolic fingerprinting method, was disturbed among all animals following weaning. This disturbance was more pronounced and lasted longer among piglets exposed to pathogenic strains of E. coli. All piglets exposed to pathogenic E. coli shed these strains in faeces. Diarrhoea was induced in the groups exposed to E. coli, but not among the control animals. Pigs not treated with ACTH and subjected to a single pathogenic strain of E. coli became infected but did not develop diarrhoea unless if coinciding with shed of rotavirus. Control pigs excreting rotavirus had no diarrhoea. Diarrhoea was most frequent in the groups exposed to three pathogenic strains of E. coli, and in these groups diarrhoea was seen in the absence of rotavirus. ACTH administration amplified the clinical signs. The litter of origin influenced the development of post-weaning diarrhoea.
Department of Ruminant and Porcine Diseases, National Veterinary Institute, 751 89 Uppsala, Sweden lennart.melin@sva.se
L
L
Melin
S
S
Mattsson
M
M
Katouli
P
P
Wallgren
D000822:Animal Husbandry; D000818:Animals; D000831:Animals, Newborn; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary*; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D006854:Hydrocortisone / Q000097:blood; D012401:Rotavirus / Q000302:isolation & purification; D013312:Stress, Physiological / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014886:Weaning
D006854:Hydrocortisone