Influence of L-arginine and vitamin C on the autonomic nervous system in chronic heart failure secondary to ischemic cardiomyopathy.
In this study, we used spectral analysis to assess changes in respiratory recording variability during infusion of L-arginine and vitamin C, individually or together, in patients with chronic heart failure. We found that healthy subjects have a substantial ability to modulate sympathetic-mediated peripheral vascular resistance through endothelial synthesis of nitric oxide. Patients with chronic heart failure lose this ability.
Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università La Sapienza, Rome, Italy. gianfranco.piccirillo@uniroma1.it
Gianfranco
G
Piccirillo
Quaglione
Q
Raffaele
Filippo
F
Fimognari
Antonio
A
Moisè
Malavasi
M
Mario
Marco
M
Lionetti
Camilla
C
Naso
Silvia
S
Di Carlo
Marialuce
M
Nocco
Damiano
D
Magrì
D000465:Algorithms; D000975:Antioxidants / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000503:physiopathology*; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications; D012119:Respiration / Q000187:drug effects*; D012815:Signal Processing, Computer-Assisted; D016037:Single-Blind Method; D014655:Vascular Resistance / Q000187:drug effects
D000975:Antioxidants; D001120:Arginine; D001205:Ascorbic Acid