First molecular identification of human Dobrava virus infection in central Europe.
Viral RNA was amplified by reverse transcription-PCR from a patient suffering from hemorrhagic fever with renal syndrome (HFRS) in Germany. The virus strain could be assigned to the Dobrava hantavirus (DOBV). This is the first molecular identification of human infection by DOBV in central Europe and the first proof that a virus strain related to the DOBV-Aa lineage, carried by Apodemus agrarius rodents, is able to cause HFRS.
Institute of Virology, University Hospital Charité, D-10098 Berlin, Germany.
Boris
B
Klempa
Morten
M
Schütt
Brita
B
Auste
Milan
M
Labuda
Rainer
R
Ulrich
Helga
H
Meisel
Detlev H
DH
Krüger
D000328:Adult; D000818:Animals; D005858:Germany; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000175:diagnosis* / Q000635:transmission; D006474:Hemorrhagic Disorders / Q000150:complications / Q000821:virology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000821:virology; D008297:Male; D008969:Molecular Sequence Data; D009115:Muridae / Q000821:virology; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D012367:RNA, Viral