Alpha 2A adrenergic receptor gene and suicide.
Suicide is a complex trait resulting from the interaction of several predisposing factors, among which genes seem to play an important role. Alterations in the noradrenergic system have been observed in postmortem brain studies of suicide victims when compared to controls. The purpose of this study was to test the hypothesis that genetic variants of the alpha(2A) adrenergic receptor gene are implicated in suicide and/or have a modulatory effect on personality traits that are believed to mediate suicidal behavior. We studied a sample of suicides (N=110) and control subjects (N=130) for genetic variation at four loci, including three in the promoter region (g-1800t, c-1291 g and the g-261a) of the alpha(2A) adrenergic receptor gene, and a potentially functional locus, N251K, which leads to an amino acid change (asparagine to lysine). No significant differences were observed at the promoter loci in terms of allelic or genotypic distribution between suicides and controls. However, analysis of the functional polymorphism N251K revealed that the 251 K allele was only present among suicides, though only three suicide cases had this allele, two of which were homozygous. These results are preliminary. If confirmed, they suggest that variation at the alpha(2A) adrenergic receptor gene may play a role in a small proportion of suicide cases.
McGill Group for Suicide Studies, Douglas Hospital, McGill University, 6875 LaSalle Blvd., Verdun, QC, Canada H4H 1R3.
Adolfo
A
Sequeira
Firoza
F
Mamdani
Aleksandra
A
Lalovic
Milena
M
Anguelova
Alain
A
Lesage
Monique
M
Seguin
Nadia
N
Chawky
Alex
A
Desautels
Gustavo
G
Turecki
D000328:Adult; D017931:DNA Primers / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D015870:Gene Expression; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data*
D017931:DNA Primers; D018341:Receptors, Adrenergic, alpha-2