Synthesis and antibacterial activities of new bis-benzimidazoles.
Twenty bis-benzimidazole derivatives were synthesised by the reaction of benzimidazole with appropriate alkyl halides. The compounds synthesised were identified by 1H, 13C-NMR, FT-IR and micro analysis. All compounds studied in this work were screened for their in vitro antibacterial activity against standard strains; Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853). Ten of the compounds were found effective to inhibit the growth of gram-positive bacteria (E. faecalis and S. aureus) at MIC (minimal inhibitory concentration) values between 50-400 microg/ ml. Two of the compounds showed MIC values of 200 microg/ml against gram-negative bacteria (E. coli and P. aeruginosa).
Küçükbay
Hasan
H
Department of Chemistry, Faculty of Arts and Sciences, Inönü University, Malatya, Turkey.
Durmaz
Riza
R
Okuyucu
Naif
N
Günal
Selami
S
Kazaz
Cavit
C
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D003470:Culture Media; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D003470:Culture Media; D007202:Indicators and Reagents