Age-related retinal degeneration in animal models of aging: possible involvement of taurine deficiency and oxidative stress.
There is strong evidence that the retina degenerates with age. Electroretinogram deficits and photoreceptor cell death and structural abnormalities have been observed in both animal and human studies of aging. The mechanism behind this phenomenon is a very interesting area for scientific and medical study. Current data support the link between retinal degeneration and increased oxidative stress. Taurine is a free amino acid found in high millimolar concentrations in the retina, and age-related deficiency in retinal levels of taurine may contribute to the retinal degeneration associated with age. Taurine acts as an antioxidant and taurine replenishment is known to alleviate oxidative stress in the retina. Thus taurine supplementation may be useful in the treatment of age-related retinal dysfunction.
Militante
Julius
J
Department of Pharmacology, Texas Tech University, Health Sciences Center, Lubbock, Texas 79430, USA.
Lombardini
John B
JB
D000375:Aging / Q000473:pathology*; D000818:Animals; D004596:Electroretinography; D006801:Humans; D023421:Models, Animal; D018384:Oxidative Stress; D051381:Rats; D012160:Retina / Q000378:metabolism; D012162:Retinal Degeneration; D013654:Taurine / Q000172:deficiency* / Q000378:metabolism
D013654:Taurine