[Dynamics of prekallikrein and kallikrein inhibitors in development of acute pulmonary lesion (experimental study)].
The reaction of the kallikrein-kinin blood system was studied in an experimental acute pulmonary lesion caused by a prolonged intravenous infusion of thrombin solution. It was established that the progressing of the acute pulmonary lesion brings about an increasing activation of the kallikrein-kinin blood system with a limited check by the lungs. It is displayed by lower levels of prekallikrein and its inhibitors observed first in the venous and later in the arterial blood. Bradykinin was shown to exhaust and impair the metabolic pulmonary activity. The conclusion is that the indices of the kallikrein-kinin blood system reflect the integrity of the pulmonary metabolic activity and can be biochemical markers of an acute pulmonary lesion.
G N
GN
Meshcheriakov
D A
DA
Ostapchenko
I O
IO
Zaks
A V
AV
Vlasenko
D000208:Acute Disease; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D004195:Disease Models, Animal; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008171:Lung Diseases / Q000097:blood*; D008297:Male; D020842:Plasma Kallikrein / Q000037:antagonists & inhibitors*; D011288:Prekallikrein / Q000378:metabolism*; D051381:Rats
D011288:Prekallikrein; D020842:Plasma Kallikrein; D001920:Bradykinin