Loss of PTEN expression is not uncommon, but lacks prognostic value in stage I NSCLC.
The PTEN gene is a tumor-suppressor gene that is inactivated in several types of human tumors. The loss of PTEN expression has been supported as a prognostic marker. Using immunohistochemical analysis, we retrospectively analyzed PTEN expression in specimens from 53 patients with completely resected stage I non-small cell lung cancer (NSCLC) for whom clinical follow-up data were available. Seven of the 53 specimens showed a total lack of staining for PTEN. No statistically significant relationship could be found between PTEN expression and clinicopathological parameters. Although genetic alterations of the PTEN gene are rare in NSCLC, loss of PTEN protein is not an uncommon event in early-stage NSCLC (13.2%). Here, we also report that the level of PTEN protein expression is not an independent prognostic marker in early-stage NSCLC.
Olaussen
Ken Andre
KA
CEA-DSV/DRR/LRO, 18 Route du Panorama, 92265 Fontenay aux Roses, France.
Soria
Jean-Charles
JC
Morat
Luc
L
Martin
Antoine
A
Sabatier
Laure
L
Morere
Jean-Francois
JF
Khayat
David
D
Spano
Jean-Philippe
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000145:classification / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking