Increased platelet CD63 and P-selectin expression persist in atherosclerotic ischemic stroke.
Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and collagen. Measurements were made 24 and 72 h and 7 and 90 days after the ischemic event in 29 patients with atherosclerotic ischemic stroke. Platelet aggregability was significantly decreased after 72 h compared to that at 24 h of stroke onset. However, platelet CD63 and P-selectin expression remained high even 90 days after the events. These findings suggest that platelet hyperactivation in atherosclerotic ischemic stroke may be sustained for a considerable period.
Department of Neurology, College of Medicine, Dong-A University, Busan, South Korea. nrcjk@unitel.co.kr
Jae-Kwan
JK
Cha
Wol-Soon
WS
Jo
Hyun Chul
HC
Shin
Hae-Rahn
HR
Bae
Jeong-Min
JM
Ho
Jae Woo
JW
Kim
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology; D015703:Antigens, CD / Q000097:blood*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D002545:Brain Ischemia / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D000077144:Clopidogrel; D003094:Collagen / Q000494:pharmacology; D005260:Female; D005434:Flow Cytometry; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D018579:Patient Selection; D015539:Platelet Activation / Q000187:drug effects; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010976:Platelet Count; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis; D010980:Platelet Membrane Glycoproteins; D020521:Stroke / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D060149:Tetraspanin 30; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D000925:Anticoagulants; D015703:Antigens, CD; C554586:CD63 protein, human; D008055:Lipids; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors; D019038:Platelet Glycoprotein GPIb-IX Complex; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30; D000244:Adenosine Diphosphate; D006493:Heparin; D003094:Collagen; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin