Analysis of datasets showing which compounds kill which organisms: inferring two systems.
Experiments are sometimes conducted to show which of several compounds is successful at inactivating which of several microorganisms. This paper proposes a method of analysing the datasets obtained. The example refers to 33 compounds (2,4-dihydroxythiobenzanilides) and seven microorganisms (dermatophytes) [data from Eur. J. Med. Chem. 35 (2000) 393]. The conclusion is that two systems or modes of action are needed to explain the data.
Department of Psychology, Macquarie University, Sydney, NSW 2109, Australia. phutchin@psy.mq.edu.au
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D000813:Anilides / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D003627:Data Interpretation, Statistical; D008962:Models, Theoretical; D012042:Registries / Q000592:standards* / Q000706:statistics & numerical data*
D000813:Anilides