Expression of two androgen-induced proteins (pepsinogen C and apolipoprotein d) in epithelial skin cancers of the eyelids.
By immunohistochemistry, we investigated pepsinogen C (pepC) and apolipoprotein D (apoD) expressions in 23 basal cell (BCC) and 25 squamous cell carcinomas (SCC) of the eyelids and analyzed the possible relationship to clinicopathological parameters. A total of 3 (13%) BCC and 7 (28%) SCC stained positively for pepC, whereas 11 (47.8%) BCC and 6 (24%) SCC stained positively for apoD. No significant correlation was found between pepC and apoD expressions and patients or tumor characteristics (p > 0.05). pepC and apoD, two androgen-inducible proteins, may be expressed by BCC and SCC of the eyelids. Further studies will be necessary to determine their clinical significance.
Alvarez
María L
ML
Hospital Alvarez-Buylla and Hospital de Jove, Avilés, Asturias, Spain. mluisaalvarez@telecable.es
Barbón
Juan J
JJ
González
Luis O
LO
Lamelas
María L
ML
Vázquez
Julio
J
Vizoso
Francisco J
FJ
D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000378:metabolism*; D053399:Apolipoproteins D; D014408:Biomarkers, Tumor / Q000378:metabolism; D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005142:Eyelid Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D020115:Pepsinogen C / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
D001053:Apolipoproteins; D053399:Apolipoproteins D; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D020115:Pepsinogen C