Pimecrolimus for the treatment of vulvar lichen sclerosus in a premenarchal girl.
BACKGROUND
Lichen sclerosus is a chronic cutaneous disorder with a predilection for the vulva. Lichen sclerosus affects more than one in 900 girls. Superpotent corticosteroids like clobetasol propionate are the most effective treatment for vulvar lichen sclerosus. However, recurrence after stopping steroids is very high. As repeated courses of corticosteroids are frequently needed, there are concerns about potential side effects. Therefore, a treatment regimen that does not rely on corticosteroids may be beneficial. As lichen sclerosus is a T-lymphocyte mediated disorder, it has been suggested that pimecrolimus, a topical T-lymphocyte inhibitor, may be safe and effective for the treatment of lichen sclerosus in children.


METHODS
A 10-year-old girl with lichen sclerosus was initially treated with clobetasol. Remission was achieved, but 3 months later she had a recurrence. Subsequent treatment with clobetasol led to a breakdown of her peri-anal skin with a superimposed infection. She was then treated with pimecrolimus and remission was achieved. She has had no recurrence of active lichen sclerosus and has less burning with pimecrolimus than with clobetasol.


CONCLUSIONS
Pimecrolimus may be an effective treatment of vulvar lichen sclerosus. Pimecrolimus has been shown to be very safe in the pediatric population for the treatment of mild to moderate eczema, without causing dermal atrophy, tachyphylaxis, striae, rebound flares, or hypothalamic-pituitary axis suppression. As the recurrence rate of active lichen sclerosus in prepubertal girls treated with topical corticosteroids is high, and the majority of prepubertal girls with lichen sclerosus continue to have disease after menarche, a treatment regimen that does not rely on corticosteroids may be beneficial.
Goldstein
Andrew T
AT
Johns Hopkins School of Medicine, Baltimore, Maryland, USA. obstetrics@yahoo.com
Marinoff
Stanley C
SC
Christopher
Kurt
K
D000279:Administration, Cutaneous; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018459:Lichen Sclerosus et Atrophicus / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
D007166:Immunosuppressive Agents; D016559:Tacrolimus