Uranium deposition and retention in a USTUR whole body case.
This report describes a whole body donation from a person with a documented occupational intake of uranium. USTUR Case 1002 was an adult male who died from an acute cerebellar infarct at the age of 83. He worked as a power operator, utility operator, and metal operator for 28 years in a facility that processed and handled radioactive materials. Although he suffered a number of burns from hot metal and acids, cuts, abrasions, and puncture wounds during his many years of work, there were no corresponding health physics or medical records to indicate that these occurrences needed or required excision or decontamination due to the suspicion of the deposition of radioactive material. Over the course of his employment, USTUR Case 1002 submitted numerous urine samples for uranium, plutonium, and fission product analysis. The highest single uranium value measured during this time period was approximately 30 microg L(-1) recorded during the second year of his employment. A urinary bioassay sample taken before termination of employment measured 4.3 microg L(-1). The mean urinary uranium concentration per liter per year calculated from the employee's bioassay records covering the first eleven years of monitoring averaged less than 3 microg L(-1). The ratio of 234/238U activity in the lung tissue was about 1, the same as that found in natural uranium. The highest concentration of uranium was found in a tracheobronchial lymph node. The uranium content in the various tissues of the body followed a rank order lung > skeleton > liver > kidney. Concentration of uranium in the kidney tissue was approximately 1.98 ng g(-1), about 3 orders of magnitude less than the generally accepted threshold level for permanent kidney damage of 3 microg U g(-1) and roughly equal to the 1.4 ng g(-1) reported for Reference Man. The autopsy disclosed findings not uncommon in the aged: severe atherosclerosis, areas of sclerotic kidney glomeruli with stromal fibrous scarring, and moderate to severe arterionephrosclerosis. Lung sections contained parenchymal areas of acute vascular congestion and a mild degree of anthracosis.
United States Transuranium and Uranium Registries, College of Pharmacy, Washington State University, 2710 University Drive, Richland, WA 99352, USA. jrussell@tricity.wsu.edu
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Russell
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Kathren
D000368:Aged; D000369:Aged, 80 and over; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics*; D001344:Autopsy; D001822:Body Burden; D002102:Cadaver; D006801:Humans; D008297:Male; D009688:Nuclear Reactors; D016273:Occupational Exposure / Q000032:analysis*; D009928:Organ Specificity; D012042:Registries; D014018:Tissue Distribution; D014481:United States; D014501:Uranium / Q000032:analysis* / Q000493:pharmacokinetics* / Q000652:urine; D014915:Whole-Body Counting
D000396:Air Pollutants, Radioactive; D014501:Uranium