Multiple bilateral fibroadenomas of the breasts requiring mastectomy in a renal transplant patient.
Fibroadenomas of the breast have been reported in female renal graft recipients and associated with the use of cyclosporin A (CsA). We report the case of a young patient given CsA who developed multiple bilateral fibroadenomas of the breasts 3 years after renal transplantation, leading to bilateral mastectomy. We discuss the association of CsA with fibroadenomas, the mechanisms by which the drug can act and review the literature. Based on these observations, an early conversion from CsA to tacrolimus should be considered; further observations are needed to assess the reversibility of the breast(s) lesions after such immunosuppressive regimen switch.
Department of Nephrology, Université Catholique de Louvain, Brussels, Belgium.
N
N
Kanaan
E
E
Goffin
D000293:Adolescent; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000601:surgery; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D018226:Fibroadenoma / Q000139:chemically induced* / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008408:Mastectomy
D007166:Immunosuppressive Agents; D016572:Cyclosporine