Effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in mice.
We have reported the effect of di(2-ethylhexyl)phthalate (DEHP) on the tryptophan (Trp)-niacin pathway in rats. To clarify the universal effect of DEHP on rodents, we studied whether DEHP also has an effect on Trp metabolism in mice. Mice were fed a niacin-free, 20% casein diet supplemented with DEHP for 21 days. Feeding with DEHP decreased the body weight gain and increased the liver weight in correlation with the dose level of DEHP. The administration of DEHP significantly increased the formation of quinolinic acid and the lower metabolites of the Trp-niacin pathway. The flux of niacin in the lower part of the Trp-niacin pathway in mice was enhanced by feeding with DEHP.
Ohta
Mari
M
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan.
Kitamura
Junko
J
Fukuwatari
Tsutomu
T
Sasaki
Ryuzo
R
Shibata
Katsumi
K
D000704:Analysis of Variance; D000818:Animals; D001837:Body Weights and Measures; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D009525:Niacin / Q000378:metabolism*; D017378:Quinolinic Acid / Q000652:urine; D014364:Tryptophan / Q000378:metabolism*
D009525:Niacin; D014364:Tryptophan; D004051:Diethylhexyl Phthalate; D017378:Quinolinic Acid