Transcription-coupled mutagenesis by the DNA deaminase AID.
Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.
Larson
Erik D
ED
Department of Immunology, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA.
Maizels
Nancy
N
D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics*; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase