Coordinating synaptic growth without being a nervous wreck.
The function and regulation of actin-cytoskeletal dynamics during synaptic growth is poorly understood. In this issue of Neuron, Coyle et al. report the identification of nervous wreck (nwk), a synapse-specific adaptor molecule in Drosophila that regulates synaptic growth and morphology via Wasp, a well-characterized mediator of actin dynamics.
Collins
Catherine A
CA
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA.
DiAntonio
Aaron
A
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D003599:Cytoskeleton / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000302:isolation & purification*; D009420:Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D009469:Neuromuscular Junction / Q000235:genetics* / Q000378:metabolism; D051316:Wiskott-Aldrich Syndrome Protein
D000199:Actins; D029721:Drosophila Proteins; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; C477859:WASp protein, Drosophila; D051316:Wiskott-Aldrich Syndrome Protein