Actin polymerization: riding the wave.
WAVE/SCAR has long been known to activate the actin-nucleating Arp2/3 complex in a Rac-dependent manner. Recent biochemical and genetic studies have revealed important roles for four WAVE-associated proteins in regulating WAVE function.
Smith
Laurie G
LG
Section of Cell and Developmental Biology, Universityof California San Diego, La Jolla, 92093, USA.
Li
Rong
R
D000199:Actins / Q000096:biosynthesis*; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D008840:Microfilament Proteins / Q000378:metabolism*; D008954:Models, Biological; D015513:Oncogene Proteins / Q000378:metabolism; D015398:Signal Transduction; D051300:Wiskott-Aldrich Syndrome Protein Family; D020744:rac GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D008840:Microfilament Proteins; C078332:Nck protein; D015513:Oncogene Proteins; D051300:Wiskott-Aldrich Syndrome Protein Family; D020744:rac GTP-Binding Proteins