Iron utilization and liver mineral concentrations in rats fed safflower oil, flaxseed oil, olive oil, or beef tallow in combination with different concentrations of dietary iron.
Diets with a higher proportion of polyunsaturated fatty acids (i.e., linoleic acid) have decreased iron absorption and utilization compared with diets containing a higher proportion of the saturated fatty acid stearic acid (e.g., beef tallow). However, less is known regarding the influence of other polyunsaturated or monounsaturated fatty acids, along with higher dietary iron, on iron absorption and utilization. The present study was conducted to compare the effects of dietary fat sources known to vary in (n-3), (n-6), and (n-9) fatty acids on iron utilization and liver mineral concentrations. Male weanling rats were fed a diet containing 10, 35, or 100 microg/g iron in combination with safflower oil, flaxseed oil, olive oil, or beef tallow for 8 wk. Indicators of iron status, iron utilization, and liver iron concentrations were unaffected by an interaction between the fat source and iron concentration. Plasma copper was the only variable affected by an interaction between the fat source and dietary iron. Findings of this study demonstrate that flaxseed oil and olive oil may alter tissue minerals and affect iron utilization. Further studies should be conducted to establish the effect of varying (n-3), (n-6), and (n-9) fatty acids on trace mineral status and iron utilization.
Nutritional Sciences Department, Oklahoma State University, Stillwater, OK 74078, USA.
Andrea D
AD
Shotton
Elizabeth A
EA
Droke
D000818:Animals; D002417:Cattle; D004041:Dietary Fats / Q000494:pharmacology*; D005223:Fats / Q000494:pharmacology; D019266:Iron, Dietary / Q000008:administration & dosage* / Q000378:metabolism*; D008043:Linseed Oil / Q000494:pharmacology; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008903:Minerals / Q000032:analysis*; D000069463:Olive Oil; D009929:Organ Size / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012450:Safflower Oil / Q000494:pharmacology; D014131:Trace Elements / Q000032:analysis; D015430:Weight Gain / Q000187:drug effects
D004041:Dietary Fats; D005223:Fats; D019266:Iron, Dietary; D008903:Minerals; D000069463:Olive Oil; D010938:Plant Oils; D014131:Trace Elements; D012450:Safflower Oil; D008043:Linseed Oil; C013698:tallow