[Proceedings on the toxicity of a new hydroxylammonium nitrate (HAN)-based liquid propellant].
Hydroxylammonium nitrate (HAN) is the main active toxic component of the new HAN-based liquid propellant. It is a moderately toxic and caustic substance to animals, and can be administrated through dermal, oral or respiratory route. HAN causes severe damage to skins, eyes, and red blood cells of the hematologic system. Significant signs of HAN poisoning include hemolytic anemia, methemoglobinemia, splenomegaly, erythrocyte destruction and Heinz body formation. This review summarize the toxicity of hydroxylammonium nitrate, and discuss the primary protection methods.
Lu
Li-lin
LL
Department of Chemistry, Beijing Normal University, Beijing, China.
Yan
Xi
X
Wang
Jian-ying
JY
Hu
Wen-xiang
WX
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D004983:Ethanolamines / Q000633:toxicity*; D005260:Female; D006898:Hydroxylamines / Q000633:toxicity*; D007928:Lethal Dose 50; D008098:Litter Size / Q000187:drug effects*; D008297:Male; D008706:Methemoglobin / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004338:Drug Combinations; D004983:Ethanolamines; D006898:Hydroxylamines; C096924:XM46 liquid propellant; D008706:Methemoglobin