The influence of follicular migration on T-cell differentiation.
The sequence of events that leads to the development of a T-dependent B-cell response has been studied for many years and much attention has focused on the importance of these interactions for the B cell and the antibody response. While a role for B cells in T-cell memory has been demonstrated, the cellular and molecular mechanisms underlying this are unclear and the importance for T cells to migrate into follicles and interact with B cells has received relatively little attention. These interactions between T and B lymphocytes are facilitated by a co-ordinated series of migration events within lymph nodes and here we propose that this migration and these events are essential for the terminal differentiation of all CD4+ T cells and without it tolerance may result.
Division of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK.
Karen M
KM
Smith
James M
JM
Brewer
Allan Mci
AM
Mowat
Yacov
Y
Ron
Paul
P
Garside
D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*