Type 2 diabetes mellitus: a disease of the innate immune system? An update.
A few years ago a hypothesis was proposed suggesting that elements of the innate immune system, such as acute phase reactants, contribute to the development of Type 2 diabetes mellitus. Acute phase reactants such as C-reactive protein and sialic acid may thus predict risk of developing Type 2 diabetes mellitus, as well as being markers of diabetes microvascular and macrovascular complications. This article discusses these issues.
Clinical Biochemistry, University Hospital Lewisham, London, UK. martin.crook@gstt.sthames.nhs.uk
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D000209:Acute-Phase Proteins / Q000276:immunology; D015415:Biomarkers; D002097:C-Reactive Protein / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology* / Q000517:prevention & control; D003925:Diabetic Angiopathies / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D019158:N-Acetylneuraminic Acid / Q000276:immunology; D012307:Risk Factors
D000209:Acute-Phase Proteins; D015415:Biomarkers; D002097:C-Reactive Protein; D019158:N-Acetylneuraminic Acid