A perspective on inversin.
Over the past 5 years, there has been increasing evidence for the role of primary (9+0) cilia in renal physiology and in establishing the left-right axis. The cilia in the renal tract are immotile and thought to have a sensory function. Cilia at the murine embryonic node have a vortical movement that sets up a leftward flow. Inversin, the protein defective in the inv mouse and in patients with type-2 nephronophthisis, localizes to both renal and node primary cilia. However, we present evidence that it is also expressed before the node forms and that its subcellular localization in renal tubular cells is not confined to the cilia. Its role in both the pathway determining left-right axis and renal function remains to be elucidated.
Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.
Lorraine
L
Eley
Lee
L
Turnpenny
Laura M
LM
Yates
A Scott
AS
Craighead
David
D
Morgan
Catherine
C
Whistler
Judith A
JA
Goodship
Tom
T
Strachan
D000818:Animals; D015820:Cadherins / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D002923:Cilia / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D007668:Kidney / Q000502:physiology; D051379:Mice; D020409:Molecular Motor Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D015820:Cadherins; D002147:Calmodulin; D003598:Cytoskeletal Proteins; C491947:Invs protein, mouse; D020409:Molecular Motor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin