Synthesis and biological evaluation of thiophene [3,2-b] pyrrole derivatives as potential anti-inflammatory agents.
A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 position and 2, 5 positions of thiophene [3,2-b] pyrrole with different functional groups.
Process Chemistry R & D, Technology Development Center, Dr. Reddy's Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India.
P Rajender
PR
Kumar
S
S
Raju
P Satish
PS
Goud
M
M
Sailaja
M R
MR
Sarma
G Om
GO
Reddy
M Prem
MP
Kumar
V V R M Krishna
VV
Reddy
T
T
Suresh
Pragathi
P
Hegde
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011758:Pyrroles; D013876:Thiophenes; D010894:Piroxicam; C059451:lornoxicam; C032801:tenoxicam