Pathophysiology of adult urinary incontinence.
The anatomic structures that prevent stress incontinence, urinary incontinence during elevations in abdominal pressure, can be divided into 2 systems: a sphincteric system and a supportive system. The action of the vesical neck and urethral sphincteric mechanisms at rest constrict the urethral lumen and keep urethral closure pressure higher than bladder pressure. The striated urogenital sphincter, the smooth muscle sphincter in the vesical neck, and the circular and longitudinal smooth muscle of the urethra all contribute to closure pressure. The mucosal and vascular tissues that surround the lumen provide a hermetic seal, and the connective tissues in the urethral wall also aid coaptation. Decreases in striated muscle sphincter fibers occur with age and parity, but the other tissues are not well understood. The supportive hammock under the urethra and vesical neck provides a firm backstop against which the urethra is compressed during increases in abdominal pressure to maintain urethral closure pressures above rapidly increasing bladder pressure. The stiffness of this supportive layer is presumed to be important to the degree to which compression occurs. This supporting layer consists of the anterior vaginal wall and the connective tissue that attaches it to the pelvic bones through the pubovaginal portion of the levator ani muscle and also the tendinous arch of the pelvic fascia. Activation of the levator muscle during abdominal pressurization is important to this stabilization process. The integrity of the connection between the vaginal wall and tendinous arch also plays an important role.
Department of Obstetrics and Gynecology, Institute of Gerontology, University of Michigan at Ann Arbor, 48109-0276, USA. delancey@umich.edu
John O L
JO
Delancey
James A
JA
Ashton-Miller
D000328:Adult; D006801:Humans; D014513:Ureter / Q000033:anatomy & histology / Q000502:physiology; D014521:Urethra / Q000033:anatomy & histology / Q000502:physiology; D001743:Urinary Bladder / Q000033:anatomy & histology / Q000502:physiology; D014550:Urinary Incontinence, Stress / Q000473:pathology* / Q000503:physiopathology*; D014554:Urination / Q000502:physiology*