Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration.
Oleoylethanolamide (OEA) is an endogenous lipid that contributes in important ways to the peripheral regulation of food intake. When administered intraperitoneally, OEA is a potent satiety-inducing anorexiant in rats and mice [Nature 414 (2001) 209; Neuropsycopharmacology 28 (2003) 1311; Nature 425 (2003) 90]. In the present study, we show that oral administration of OEA in pH-sensitive enteric-coated capsules produces a profound and long-lasting inhibition of food intake in free-feeding rats. This effect is accompanied by a marked elevation in OEA levels in the small intestine, but not in brain or muscle.
Department of Pharmacology, University of California, Irvine, CA 92697-4625, USA.
Fariba
F
Oveisi
Silvana
S
Gaetani
Kevin Tai-Pang
KT
Eng
Daniele
D
Piomelli
D000284:Administration, Oral; D000818:Animals; D001067:Appetite Depressants / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics; D002214:Capsules; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004435:Eating / Q000187:drug effects*; D063388:Endocannabinoids; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005544:Forecasting; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D007441:Intubation, Gastrointestinal; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009829:Oleic Acids / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects / Q000502:physiology
D001067:Appetite Depressants; D002214:Capsules; D063388:Endocannabinoids; D009829:Oleic Acids; C488250:oleoylethanolamide