Non-pigmenting fixed drug eruption caused by allylisopropylacetylurea.
An unusual case of a non-pigmenting fixed drug eruption caused by allylisopropylacetylurea is reported. Several hours after taking an analgesic (New Kaiteki A), a 30-year-old Japanese woman, who had experienced similar eruptions several times after taking other analgesics, developed numerous variously sized, itchy, round-to-oval erythematous eruptions on the trunk and extremities. After she discontinued taking this drug, all such eruptions resolved within 2 weeks, without leaving postinflammatory pigmentation. Patch testing with New Kaiteki A itself and one of its active ingredients, allylisopropylacetylurea, on lesional skin, but not on uninvolved skin, showed positive erythematous reactions after 2 days.
Numata
Yukikazu
Y
Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryou-machi 1-1, Aoba-ku, Sendai 980-8574, Japan. yukikazu@gonryo.med.tohoku.ac.jp
Terui
Tadashi
T
Sasai
Shu
S
Sugawara
Masayuki
M
Kikuchi
Katsuko
K
Tagami
Hachiro
H
Aiba
Setsuya
S
D000328:Adult; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000737:chemistry; D015394:Molecular Structure; D010328:Patch Tests; D014508:Urea / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000737:chemistry
D006993:Hypnotics and Sedatives; D014508:Urea; C005700:apronalide