Protein hijacking: key proteins held captive against their will.
Proteins travel to their appropriate intracellular homes by means of the targeting signals they carry. It now seems that a short, but important, list of key regulatory proteins are victims of protein hijacking: Bid, Bim, NF-kappaB, SREBP, and perhaps the intracellular portion of MUC1. These provide critical functions within a particular subcellular compartment, but are initially prevented from finding their way to this intracellular home. Only in response to specific physiological signals are these proteins released to find the site at which they act.
Traven
Ana
A
St. Vincent's Institute of Medical Research, Fitzroy 3065, Australia.
Huang
David C S
DC
Lithgow
Trevor
T
D017209:Apoptosis; D002451:Cell Compartmentation; D002455:Cell Division; D003593:Cytoplasm / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D021382:Protein Sorting Signals / Q000235:genetics*; D021381:Protein Transport / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D016328:NF-kappa B; D021382:Protein Sorting Signals; C102196:SREBP cleavage-activating protein; D014157:Transcription Factors