Fluoro-modified chemotactic peptides: fMLF analogues.
A small library of peptide analogues of the chemotactic tripeptide For-Met-Leu-Phe-NH2 modified by substitution of Leu at position 2 by three different fluorinated amino acids varying in content of fluorine, length of the fluorinated side chain, and alkylation degree at the alpha-carbon atom was synthesized. The influence of the fluorine substitution on the biological activity was investigated by measuring the oxidative activity of neutrophils using a luminol-dependent chemiluminescence assay.
Koksch
Beate
B
Department of Organic Chemistry, University of Leipzig, 04103 Leipzig, Germany. koksch@chemie.uni-leipzig.de
Dahl
Christina
C
Radics
Gabor
G
Vocks
Andreas
A
Arnold
Klaus
K
Arnhold
Jürgen
J
Sieler
Joachim
J
Burger
Klaus
K
D002633:Chemotaxis / Q000187:drug effects*; D005453:Fluorescence; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017434:Protein Structure, Tertiary
D010455:Peptides; D009240:N-Formylmethionine Leucyl-Phenylalanine