Anti-inflammatory effect of erythromycin on histamine-induced otitis media with effusion in guinea pigs.
In this study, the anti-inflammatory effect of erythromycin was investigated in a model of histamine-induced otitis media with effusion (OME). OME was induced in guinea pigs by the transtympanic injection of histamine solution into the middle-ear cavity. Guinea pigs were randomly assigned to one of three groups: control, erythromycin treatment, or methylprednisolone treatment. After histamine injection, the animals were treated with intraperitoneal medication for five days consecutively. Afterwards, the animals were sacrificed and the temporal bones were removed. The samples were examined stereologically. In the erythromycin-treated group, it was observed that neutrophil infiltration was significantly inhibited when compared to the control group. This result shows that erythromycin may produce a significant anti-inflammatory effect in this model of OME.
Department of Otorhinolaryngology-Head and Neck Surgery, Atatürk University, School of Medicine, Erzurum, Turkey.
Bülent
B
Aktan
Cemal
C
Gundogdu
Harun
H
Ucuncu
Bunyami
B
Unal
Yavuz
Y
Sütbeyaz
Sare
S
Altas
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004917:Erythromycin / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use; D006168:Guinea Pigs; D006632:Histamine; D008775:Methylprednisolone / Q000627:therapeutic use; D020556:Neutrophil Infiltration / Q000187:drug effects; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D011897:Random Allocation; D013701:Temporal Bone / Q000098:blood supply / Q000276:immunology; D014664:Vasodilation / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D004917:Erythromycin; D006632:Histamine; D008775:Methylprednisolone