[Progress in researches on sperm antigen fertilin beta].
Fertilin beta plays an important role in fertilization by its disintegrin domain as a sperm-specific antigen. This paper reviews its structure, localization and roles in fertilization, and suggests that fertilin beta, as an important target antigen, has a very promising value in the development of human immunocontraceptive vaccine.
Department of Urology, Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
Jun
J
Zhang
Yanfeng
Y
Li
D051722:ADAM Proteins; D000818:Animals; D003269:Contraception, Immunologic; D000072196:Fertilins; D005306:Fertilization; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008666:Metalloendopeptidases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D014612:Vaccines / Q000276:immunology
D008562:Membrane Glycoproteins; D014612:Vaccines; D051722:ADAM Proteins; C000606454:ADAM2 protein, human; D000072196:Fertilins; D008666:Metalloendopeptidases