[Mutation and unusual expression of clotting system-related genes and hypercoagulability].
Hypercoagulability is a risk factor for atherosclerosis (As) and plays an important role in the development of As. Hypercoagulability results from mutation and unusual expression of clotting system-related genes, anticlotting system-related genes, fibrinolytic system-related genes and other related genes. Factor V gene, prothrombin gene and tissue factor gene in clotting system, thrombomodulin gene and antithrombin III in anticlotting system, plasminogen activator inhibitor-1 gene in fibrinolytic system, are related with hypercoagulability tightly.
Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041.
Yu-Hua
YH
Zhao
Bing-Wen
BW
Liu
D000818:Animals; D001777:Blood Coagulation / Q000235:genetics*; D001779:Blood Coagulation Factors / Q000235:genetics; D005342:Fibrinolysis / Q000235:genetics*; D006801:Humans; D009154:Mutation; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D019851:Thrombophilia / Q000235:genetics*
D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1