Effect of triclosan on healing following non-surgical periodontal therapy in smokers.
BACKGROUND
Tobacco smoking is an established risk factor for periodontitis, and is associated with periodontal attachment and tooth loss. Clinical studies have indicated that smoking may adversely affect and impede healing following periodontal therapy. Adjunctive antimicrobials, on the other hand, have been shown to enhance the effect of non-surgical periodontal therapy. The objective of this study was to evaluate the effect of a triclosan/copolymer/fluoride dentifrice on healing following non-surgical periodontal therapy in smokers.


METHODS
Sixty smokers (aged 35-59 years; 23 females) with chronic periodontal disease volunteered to participate in a double-blind, randomized, controlled, clinical trial. The subjects were randomly assigned to use a triclosan/copolymer/fluoride (30 subjects) or a standard fluoride (30 subjects) dentifrice and received detailed information on proper techniques for self-performed plaque control. The participants then received non-surgical periodontal therapy followed by periodontal maintenance care every 6 months over 24 months. Clinical recordings included evaluation of oral hygiene standards, gingival health, and periodontal status.


RESULTS
Subjects using the triclosan/copolymer/fluoride dentifrice exhibited significantly improved oral hygiene conditions, gingival health, and periodontal status compared with those using the standard fluoride dentifrice over the 24-month maintenance interval.


CONCLUSIONS
The results suggest that an oral hygiene regimen including a triclosan/copolymer/fluoride dentifrice may sustain the short-term effect of non-surgical periodontal therapy in smokers.
Department of Oral Medicine and Periodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. dtvkd@mahidol.ac.th
Varunee
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Kerdvongbundit
Ulf M E
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Wikesjö
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002327:Cariostatic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D045424:Complex Mixtures; D003773:Dental Plaque / Q000517:prevention & control; D003777:Dental Prophylaxis; D003802:Dentifrices / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene; D010512:Periodontal Index; D010518:Periodontitis / Q000628:therapy*; D012824:Silicic Acid; D012907:Smoking / Q000503:physiopathology*; D014100:Toothpastes; D014260:Triclosan / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D045424:Complex Mixtures; D003802:Dentifrices; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; D005459:Fluorides