[HLA-G in organ transplantation].
The HLA-G molecule plays a crucial role in the protection of the fetus against aggression by the mother's immune system. Recently, it was shown that HLA-G was involved in the protection of the transplanted tissues, via the inhibition of all immune effectors that mediate graft rejection. The inhibitory functions of HLA-G were studied in vitro using allo- and xeno-geneic models, ex vivo on transplanted tissues biopsies, and in an in vivo animal model. In this review, we will summarize recent results which show that HLA-G acts as a regulator of immune function, seems to be directly involved in transplant acceptation, and should be taken into consideration when monitoring transplanted patients' status.
Service de recherches en hémato-immunologie, CEA-DSV-DRM, hôpital Saint-Louis, IUH, 1, avenue Claude-Vellefaux, 75010 Paris cedex 10, France.
J
J
Le Maoult
N
N
Rouas-Freiss
M
M
Le Discorde
P
P
Moreau
E D
ED
Carosella
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005333:Fetus / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D051379:Mice; D013552:Swine; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I