Recently synthesized class of vinylphosphonates as potent matrix metalloproteinase (MMP-2) inhibitors.
An in vitro evaluation of MMP-2 inhibitors for a series of novel vinylphosphonic acids and phosphonic esters that contain various functional groups, shows that various types exhibit excellent efficiency, and points towards potent, promising compounds. Other types displayed relatively weak activity.
Department of Medicinal Chemistry and Natural Products, Hebrew University in Jerusalem, Jerusalem, Israel.
Abed Al-Aziz
AA
Al-Quntar
Ofir
O
Baum
Reuven
R
Reich
Morris
M
Srebnik
D002633:Chemotaxis / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D063065:Organophosphonates / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D063065:Organophosphonates; D014753:Vinyl Compounds; C433467:vinylphosphonic acid