[Reduction in the aggressiveness of ventilation by inhalation of perfluorohexane after therapy of oleic acid-induced respiratory failure].
BACKGROUND
The application of perfluorohexane (PFH) vapor led to an improvement of oxygenation and mechanical lung function in a model of oleic acid-induced ARDS in sheep. The aim of this study was to investigate the effects of PFH on gas exchange over an extended time period and to reduce the invasiveness of ventilation.


METHODS
ARDS was induced in sheep ( n=12) by injecting 0.1 ml/kg body weight oleic acid intravenously. Six sheep were treated for 30 min with 18 vol.% PFH (PFH-Tx) and followed up over a time period of 240 min while untreated sheep ( n=6) served as controls. Subsequently the F(I)O(2) was reduced to generate a p(a)O(2) between 100-140 mmHg. Gas exchange, respiratory and hemodynamic data were collected at regular intervals. Data were analysed using covariance analysis.


RESULTS
PFH treatment led to an improvement in oxygenation ( p<0.01) and in mechanical lung function ( p<0.01). Furthermore, mean pulmonary artery pressure ( p<0.01) and shunt ( p<0.01) were lower in PFH-Tx. F(I)O(2) could be reduced in all PFH-treated animals ( p<0.01).


CONCLUSIONS
Treatment of oleic acid-induced lung injury with PFH vapor improved oxygenation and mechanical lung function over a extended time period allowing a reduction in the invasiveness of ventilation.
Klinik für Anästhesiologie und Intensivtherapie, Carl Gustav Carus Universitätsklinikum, Technische Universität, Dresden. bleyl@rcs.urz.tu-dresden.de
J-U
JU
Bleyl
U
U
Tschö
M
M
Regner
O
O
Vicent
M
M
Hübler
M G
MG
de Abreu
T
T
Koch
D M
DM
Albrecht
M
M
Ragaller
D000818:Animals; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use*; D006439:Hemodynamics; D019301:Oleic Acid; D011652:Pulmonary Circulation / Q000502:physiology; D011659:Pulmonary Gas Exchange; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D015656:Respiratory Mechanics / Q000187:drug effects / Q000502:physiology; D012756:Sheep
D005466:Fluorocarbons; D019301:Oleic Acid; C078626:perflexane