Transcription-coupled mutagenesis by the DNA deaminase AID.
Activation-induced deaminase (AID) initiates switch recombination and somatic hypermutation of immunoglobulin genes in activated B cells. Compelling evidence now shows that AID travels with RNA polymerase II to deaminate actively transcribed DNA.
Department of Immunology, University of Washington Medical School, 1959 NE Pacific Street, Seattle, WA 98195-7650, USA.
Erik D
ED
Larson
Nancy
N
Maizels
D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics*; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase