Identification of a new mouse Cd1d2 allele.
The mouse CD1 system is formed by two closely related genes named Cd1d1 and Cd1d2. Cd1d1 encodes a molecule that presents antigens to NKT cells. The function of the Cd1d2 gene has not been elucidated. Here we described a method to analyse variations in mouse Cd1 genes. We found a new allele for Cd1d2 characterized by a point mutation, resulting in a replacement of alanine at position 176 by a valine.
Immunology Unit, School of Medicine, Complutense University, Madrid, Spain.
B
B
Gozalbo-López
A
A
Pérez-Rosado
J F
JF
Parra-Cuadrado
E
E
Martínez-Naves
D000409:Alanine / Q000737:chemistry; D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D018949:Antigens, CD1 / Q000235:genetics*; D055610:Antigens, CD1d; D001483:Base Sequence; D014644:Genetic Variation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014633:Valine / Q000737:chemistry
D018949:Antigens, CD1; D055610:Antigens, CD1d; D014633:Valine; D000409:Alanine