Prolonged impact of five imprinters on the serotonin content of white blood cells and mast cells of weanling rats: outstanding effect of benzpyrene and chlorpheniramine.
In previous experiments, treatment at weaning or adult age with endorphin, serotonin or an antihistamine (late hormonal imprinting) durably influenced the serotonin content of white blood cells and mast cells of rat. In the present experiments, five molecule (approved imprinters in other indexes) were studied for imprinting effect of immune cells, 3 weeks after a single treatment at weaning. Three steroid hormone-like molecule (vitamin D3, mifepristone and dexamethasone) were ineffective (except dexamethasone in 1/4 indexes), while benzpyrene (aromatic hydrocarbon) and chlorpheniramine (H1-receptor blocker antihistamine) were highly effective (5/6 and 4/4 respectively). The results indicate: (1) a prolonged (late imprinting) effect of a single treatment with certain molecules acting at receptor level; (2) non-generality of late imprinting, and (3) the very extensive effects of benzpyrene, which in earlier experiments was one of the strongest imprinter at receptorial and behavioral level at any periods of life studied.
Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Nagyvarad ter 4, POB 370, Budapest 1445, Hungary. csagyor@dgci.sote.hu
G
G
Csaba
P
P
Kovács
Eva
E
Pállinger
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D002744:Chlorpheniramine / Q000494:pharmacology*; D005260:Female; D005434:Flow Cytometry; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D018613:Microscopy, Confocal; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D001580:Benzopyrenes; D012701:Serotonin; D002744:Chlorpheniramine