[Evaluation of microorganisms ability to beta-lactamase production in exacerbation of chronic sinusitis treated with beta-lactam antibiotics].
In our study the ability of the isolated microorganisms to produce beta-lactamase was determined. These microorganisms were isolated from sinus punctures of 115 patients before (evaluation I) and after the treatment finished (evaluation III). During first evaluation 93 microorganisms with potential ability to beta-lactamase production were isolated. 24 of them (25.81%) produced beta-lactamase, 69 (74.19%) didn't do it. 57 patients were qualified for amixycillin with potassium clavulanate treatment (subgroup A) and 58 patients for cefuroxime axetil treatment (subgroup B). After the treatment (evaluation III) in the group of 21 isolated microorganisms 6 produced beta-lactamase. The microorganisms producing beta-lactamase were isolated only from the patients where the amoxycillin with potassium clavulanate was administered.
II Katedra i Klinika Laryngologii Sl.AM w Zabrzu.
Wojciech
W
Namysłowski
Grzegorz
G
Namysłowski
Ewa
E
Buszman
Maciej
M
Misiołek
D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006090:Gram-Negative Bacteria / Q000201:enzymology*; D006094:Gram-Positive Bacteria / Q000201:enzymology*; D006801:Humans; D008297:Male; D012852:Sinusitis / Q000188:drug therapy* / Q000201:enzymology*; D001618:beta-Lactamases / Q000378:metabolism*; D047090:beta-Lactams / Q000627:therapeutic use*
D047090:beta-Lactams; D001618:beta-Lactamases; D002444:Cefuroxime