Highly conserved alpha-toxin sequences of avian isolates of Clostridium perfringens.
Clostridium perfringens causes necrotic enteritis in chickens, and alpha-toxin has been suggested to be a key virulence determinant. Analysis of the alpha-toxin of 25 chicken-derived C. perfringens strains demonstrated high homology to mammal-derived strains rather than to the only avian-derived C. perfringens alpha-toxin sequence reported previously.
Commonwealth Scientific and Industrial Research Organisation, Livestock Industries, Australian Animal Health Laboratory, Geelong 3220, Australia.
Scott A
SA
Sheedy
Aaron B
AB
Ingham
Julian I
JI
Rood
Robert J
RJ
Moore
D000595:Amino Acid Sequence; D000818:Animals; D001315:Australia; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D002135:Calcium-Binding Proteins; D002645:Chickens; D003015:Clostridium Infections / Q000175:diagnosis / Q000662:veterinary*; D003016:Clostridium perfringens / Q000302:isolation & purification*; D017124:Conserved Sequence; D017931:DNA Primers; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011201:Poultry Diseases / Q000175:diagnosis / Q000382:microbiology*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D010738:Type C Phospholipases / Q000737:chemistry / Q000235:genetics*
D001427:Bacterial Toxins; D002135:Calcium-Binding Proteins; D017931:DNA Primers; D010738:Type C Phospholipases; C040649:alpha toxin, Clostridium perfringens