Pilomatrix carcinoma with lymph node metastases.
Pilomatrix carcinoma is a rare skin tumor with an origin from hair matrix cells. The tumor is locally aggressive with a great tendency for recurrence, but the metastatic potential is limited. A pilomatrix carcinoma in 76-year-old female with lymph node metastases is presented. In addition to classical histopathological criteria and DNA ploidy analysis, a broad panel of antibodies was used for evaluation of the metastatic potential. Both primary tumor and lymph node metastasis revealed extremely high proliferation and apoptotic rates. High constant expressions of CD44v6 and P-cadherin were also observed. In the metastasis, significant reduction of E-cadherin and beta-catenin was detected. The best approach for assessment of metastatic potential of pilomatrix carcinoma seems to be the complex evaluation of routine histological criteria like vessel invasion, mitotic index, apoptotic count, and new molecular markers of cell death and adhesion.
Bassarova
Assia
A
Department of Pathology, Alexander University Hospital, Medical University, Sofia, Bulgaria.
Nesland
Jahn M
JM
Sedloev
Theophil
T
Danielsen
Håvard
H
Christova
Svetlana
S
D000368:Aged; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D002455:Cell Division; D003598:Cytoskeletal Proteins / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006201:Hair Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology; D018296:Pilomatrixoma / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D011003:Ploidies; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015534:Trans-Activators / Q000378:metabolism; D051176:beta Catenin
D014408:Biomarkers, Tumor; C112697:CD44v6 antigen; C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D004273:DNA, Neoplasm; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D015534:Trans-Activators; D051176:beta Catenin