Low p27 expression predicts biochemical relapse after radical prostatectomy in patients with clinically localised prostate cancer.
OBJECTIVE
To assess the prognostic value of p27 protein expression in clinically localised prostate cancer with respect to biochemical recurrence after radical prostatectomy.


METHODS
Fifty-two patients (median age 63 years) with prostate cancer were treated by radical prostatectomy in an 18-month period. Data recorded: preoperative PSA level, histopathological Gleason grade, pathological stage and status of surgical margins. p27 expression was evaluated in this group of tumors by immunohistochemistry (positivity was defined as > or = 30% positive cells). Biochemical relapse (BR) was defined by a serum PSA level > or = 0.3 ng/ml.


RESULTS
Twenty-two out of 47 patients (47%) with available follow-up showed a low p27 protein expression. p27 expression did not correlate with pathological stage, Gleason score, serum PSA levels or the status of the surgical margins. Patients presented with BR during the follow-up (risk of BR (RBR) at 36 months: 40%). Patients with low p27 expression showed a higher RBR than the others (RBR 36-month 59% vs. 18%, respectively; p = 0.02). In a multivariate analysis, only p27 along with stage maintained the predictive value for biochemical relapse.


CONCLUSIONS
p27 expression is a promising prognostic factor in prostate cancer, since it has proved to be a predictor of biochemical relapse.
Departments of Urology and Kidney Transplant, Hospital Clinic, Institut d'Investigacio Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain. mjribal@fundacio-puigvert.es
Maria J
MJ
Ribal
Pedro L
PL
Fernandez
Armando
A
Lopez-Guillermo
Xavier
X
Farré
Yolanda
Y
Santos
Roser
R
Gibanel
Antonio
A
Cardesa
Antonio
A
Alcaraz
D000368:Aged; D018797:Cell Cycle Proteins / Q000096:biosynthesis*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*
D018797:Cell Cycle Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27