[Clinical application of proton MR spectroscopy to hyperacute ischemic brain disease].
We examined the usefulness of proton magnetic resonance spectroscopy ((1)H-MRS) for imaging diagnosis in 50 outpatients and 42 emergency patients with hyperacute ischemic brain disease. In hyperacute ischemic brain disease, a reduction of N-acetylaspartate and the appearance of lactate were found in the spectrum from immediately after the development of symptoms. Thereafter, a decrease in N-acetylaspartate and increase in lactate was observed with time, and the pattern of the spectrum was categorized. Moreover, evaluation of the penumbra was considered, including its relation with the intra-arterial signal as determined by the T(2) fluid-attenuated inversion recovery image of magnetic resonance imaging. Our results obtained from the use of proton MR spectroscopy to perform cerebral evaluation on a cellular level were examined by evaluation of the ischemic penumbra of an ischemic brain disease, and were considered to be useful.
Department of Radiology, Minano Hospital, Medical Co-operative Association of Saitama.
Mitsuru
M
Ichihara
Yuki
Y
Nakamura
Tomohiko
T
Okawa
D000208:Acute Disease; D002545:Brain Ischemia / Q000175:diagnosis*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D011522:Protons; D012189:Retrospective Studies; D012984:Software; D013997:Time Factors
D011522:Protons