Heat shock proteins in mammalian development.
Mammalian development follows a defined but adjustable program, depending on the plasticity of embryonic cells 'response to environmental changes. Heat shock proteins (Hsp) are integral part of this developmental program and gene targeting experiments have started to unravel developmental processes, which exhibit specific requirements for Hsps (e.g. Hsp70.2 for spermatogenesis). In the present paper, we will review available data on Hsp function and discuss the roles of heat shock factors (HSF), their major regulators, in mammalian development.
Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA. ec1402@yahoo.com
Elisabeth S
ES
Christians
Qi
Q
Zhou
JeanPaul
J
Renard
Ivor J
IJ
Benjamin
D000818:Animals; D005314:Embryonic and Fetal Development; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D013091:Spermatogenesis / Q000502:physiology*
D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins