Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.
Structure-activity relationships for a series of benzimidazol-2-one-based inhibitors of respiratory syncytial virus are described. These studies focused on structural variation of the benzimidazol-2-one substituent, a vector inaccessible in a series of benzotriazole derivatives on which 2 is based, and revealed a broad tolerance for substituent size and functionality.
Yu
Kuo-Long
KL
Department of Chemistry, The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.
Zhang
Yi
Y
Civiello
Rita L
RL
Trehan
Ashok K
AK
Pearce
Bradley C
BC
Yin
Zhiwei
Z
Combrink
Keith D
KD
Gulgeze
H Belgin
HB
Wang
Xiangdong Alan
XA
Kadow
Kathleen F
KF
Cianci
Christopher W
CW
Krystal
Mark
M
Meanwell
Nicholas A
NA
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects* / Q000502:physiology
D000998:Antiviral Agents; D001562:Benzimidazoles; C053110:benzimidazol-2-one