Inclusion complex of fenbufen with beta-cyclodextrin.
An inclusion complex of fenbufen with beta-cyclodextrin (beta-CD) in aqueous solution was characterized by (1)H-NMR spectroscopy. The [1:1] stoichiometry was determined and a stability constant of several 1000s (M(-1)) was calculated. The geometry of the inclusion complex was established based on MM(+) molecular mechanics calculations.
National R and D Institute of Isotopic and Molecular Technologies, PO Box 700, Cluj-Napoca, Romania. ibratu@s3.itim-cj.ro
I
I
Bratu
J M
JM
Gavira-Vallejo
A
A
Hernanz
M
M
Bogdan
Gh
G
Bora
D003505:Cyclodextrins / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D007004:Hypoglycemic Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010654:Phenylbutyrates / Q000737:chemistry*; D012996:Solutions; D013816:Thermodynamics; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D004338:Drug Combinations; D007004:Hypoglycemic Agents; D010654:Phenylbutyrates; D012996:Solutions; D047392:beta-Cyclodextrins; D014867:Water; C010725:fenbufen; C031215:betadex