Presence of cytomegalovirus in cerebrospinal fluid of patients with Guillain-Barre syndrome.
BACKGROUND
Because poliomyelitis has been almost completely eradicated, Guillain-Barre syndrome (GBS) now accounts for most cases of acute flaccid paralysis. Understanding of the role of cytomegalovirus (CMV) in the pathogenesis of GBS is still very limited.


METHODS
We identified 42 CMV-seropositive patients with GBS between 1998 and 2001. Cerebrospinal fluid (CSF) and serum samples obtained from these patients were tested by CMV-specific polymerase chain reaction, and the glycoprotein B (gB) segment of the detected CMV genome was analyzed. Virological findings were compared with clinical characteristics and CSF laboratory values.


RESULTS
CMV DNA was detected in 13 (31%) of 42 CSF samples from patients with GBS but was not detected in 42 CSF samples from age-matched control subjects with acute encephalopathy. CSF samples obtained early after the onset of GBS were significantly more likely to be positive for CMV DNA (P=.048). gB1 was the most prevalent genotype detected in patients with GBS (88%), followed by gB3 (8%) and gB2 (4%).


CONCLUSIONS
CMV DNA was detected frequently in CSF samples from CMV-seropositive patients with GBS, especially early during the course of the disease. The clinical significance of this finding has yet to be elucidated, but early administration of antiviral therapy might prove to be beneficial for selected patients with GBS.
Institute of Virology, University of Vienna, Austria. c.steininger@uke.uni-hamburg.de
Christoph
C
Steininger
Theresia
T
Popow-Kraupp
Andreas
A
Seiser
Nevzat
N
Gueler
Gerold
G
Stanek
Elisabeth
E
Puchhammer
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification*; D004279:DNA, Viral / Q000134:cerebrospinal fluid*; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid / Q000821:virology*; D006801:Humans; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid; D008875:Middle Aged; D014759:Viral Envelope Proteins / Q000235:genetics
D004279:DNA, Viral; D007075:Immunoglobulin M; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus