Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?
In this mini-review, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to a variety of oxidative stresses. The role of nitric oxide and nitration in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.
Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, USA.
Srigiridhar
S
Kotamraju
Yoshiko
Y
Tampo
Shasi V
SV
Kalivendi
Joy
J
Joseph
Christopher R
CR
Chitambar
B
B
Kalyanaraman
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D003546:Cysteine Endopeptidases / Q000502:physiology*; D004727:Endothelium / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000502:physiology*; D017942:Nitric Acid / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D015398:Signal Transduction / Q000502:physiology*
D009097:Multienzyme Complexes; D017942:Nitric Acid; D007501:Iron; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex