Concentrations of B vitamins and homocysteine in children with sickle cell anemia.
BACKGROUND
Elevated concentration of serum homocysteine contributes to thrombosis, a frequent event in patients with sickle cell anemia. We aimed to test whether children with sickle cell anemia have elevated concentrations of serum homocysteine with diminished levels of folate or B vitamins from accelerated blood cell turnover.


METHODS
We conducted a case-control study of children with homozygous sickle cell anemia (n = 17) and unaffected children (n = 11). We measured serum and red blood cell folate, vitamin B6, vitamin B12, and homocysteine concentrations, and assessed micronutrient intake.


RESULTS
Children with sickle cell anemia had concentrations of homocysteine slightly higher than those of unaffected children. They had lower vitamin B6 concentrations and comparable concentrations of folate and vitamin B12. Homocysteine concentration was inversely related to vitamin B12 concentration and was not independently associated with levels of vitamin B6 or folate.


CONCLUSIONS
Despite comparable intake, children with sickle cell anemia had lower concentrations of vitamin B6 than unaffected children. Larger studies are needed to determine if chronically low serum vitamin B6 concentration contributes to hyperhomocysteinemia in this population.
Department of Medicine and Pediatrics, the Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA. jsegal@jhmi.edu
Jodi B
JB
Segal
Edgar R
ER
Miller
Nga Hong
NH
Brereton
Linda M S
LM
Resar
D000755:Anemia, Sickle Cell / Q000097:blood*; D044383:Black People; D016022:Case-Control Studies; D002648:Child; D004032:Diet; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D025101:Vitamin B 6 / Q000097:blood*; D014815:Vitamins / Q000008:administration & dosage
D014815:Vitamins; D006710:Homocysteine; D025101:Vitamin B 6; D005492:Folic Acid