RNA ligase; picking up the pieces.
In the current issue of Structure, Ho and coworkers report the crystal structure and mechanism of a T4 RNA ligase. These studies provide valuable insights on the mechanism and origin of RNA and DNA ligases, and RNA capping enzymes.
Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, OR 97403, USA.
Zachary A
ZA
Wood
Robert S
RS
Sabatini
Stephen L
SL
Hajduk
D000255:Adenosine Triphosphate / Q000378:metabolism; D018360:Crystallography, X-Ray; D011088:DNA Ligases / Q000737:chemistry / Q000378:metabolism; D004260:DNA Repair; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D012315:RNA Caps / Q000378:metabolism; D011130:RNA Ligase (ATP) / Q000737:chemistry / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000378:metabolism*
D012315:RNA Caps; D014764:Viral Proteins; D000255:Adenosine Triphosphate; D011088:DNA Ligases; D011130:RNA Ligase (ATP); C467724:bacteriophage T4 RNA ligase 2