Cost-effectiveness of nucleic acid test screening of volunteer blood donations for hepatitis B, hepatitis C and human immunodeficiency virus in the United States.
OBJECTIVE
The aim of this study was to examine the cost-effectiveness of adding nucleic acid testing (NAT) to serological (antibody and antigen) screening protocols for donated blood in the United States (US) with the purpose of reducing the risks of transfusion-transmission of hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV).


METHODS
The costs, health consequences and cost-effectiveness of adding either minipool or individual-donor NAT to serological screening (SS) testing were estimated using a decision-analysis model.


RESULTS
With the given modelling assumptions, adding minipool NAT would avoid an estimated 37, 128 and eight cases of HBV, HCV and HIV, respectively, and save approximately 53 additional years of life and 102 additional quality adjusted life years (QALYs) compared with SS, at a net cost of $154 million. SS + minipool NAT - p24 compared with SS alone resulted in an incremental cost-effectiveness ratio of $1.5 million per QALY gained (range in sensitivity analysis $1.0-2.1 million per QALY gained) in this US analysis.


CONCLUSIONS
The cost effectiveness of adding NAT screening is outside the typical range for most healthcare interventions, but not for established blood safety measures.
Marshall
D A
DA
Innovus Research Inc., Burlington, Canada. dmarshall@innovus.com
Kleinman
S H
SH
Wong
J B
JB
AuBuchon
J P
JP
Grima
D T
DT
Kulin
N A
NA
Weinstein
M C
MC
D001782:Blood Donors; D003362:Cost-Benefit Analysis; D015658:HIV Infections / Q000175:diagnosis / Q000191:economics / Q000635:transmission; D006509:Hepatitis B / Q000175:diagnosis / Q000191:economics / Q000635:transmission; D006526:Hepatitis C / Q000175:diagnosis / Q000191:economics / Q000635:transmission; D006801:Humans; D008403:Mass Screening / Q000191:economics* / Q000379:methods; D018803:Models, Economic; D021141:Nucleic Acid Amplification Techniques / Q000191:economics*; D014481:United States; D014777:Virus Diseases / Q000175:diagnosis* / Q000191:economics / Q000635:transmission