Systemic administration of naked DNA: gene transfer to skeletal muscle.
Skeletal muscle is a promising target tissue for the gene therapy of both muscle and non-muscle disorders. Gene transfer into muscle tissue can produce a variety of physiologically active proteins and may ultimately be applied to the treatment of many diseases. A variety of methods have been studied to transfer genes into skeletal muscle, including viral and non-viral vectors. In this review, we discuss recent developments in the non-viral delivery of genes to muscles.
Liu
F
F
Center for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, PA 15213, USA.
Liang
K W
KW
Huang
L
L
D000818:Animals; D004247:DNA / Q000008:administration & dosage*; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000628:therapy*; D009137:Muscular Dystrophy, Animal / Q000628:therapy; D019076:Transgenes
D004247:DNA