[Effects of autologous hematopoietic stem cell transplantation on immune function in patient with systemic lupus erythematosus].
To investigate the effects of autologous hematopoietic stem cell transplantation (AHSCT) on immune index in patient with systemic lupus erythematosus (SLE), and evaluate its treatment outcome, the flow cytometry (FCM) and enzyme linked immunosorbent assay (ELISA) were used to detect the leukocyte differentiation antigen, sIL-2R, IL-6, C3, C4, autoantibodies, immunoglobulin for 33 case of SLE before transplantation and at 1, 3, 6, 12 months after transplantation. The results showed that the ratio of CD4(+), CD19(+) cell, the level of sIL-2R, IL-6 and the positive rate of autoantibodies were significantly lower, CD8(+), CD16(+)CD56(+) cell and C3, C4 were higher than those before transplantation. Out of the 33 patients, 26 achieved CR, 3 reached PR and 4 relapsed at 4 - 6 months after transplantation. It is concluded that the immune indexes of patients with SLE changed significantly following AHSCT. These immune indexes may be indications to predict the status of remission in patient with SLE.
Department of Hematology, The Third People Hospital of Zhengzhou, Zhengzhou, 450000 China.
Shu-Yi
SY
Wu
Xiao-Wu
XW
Zhao
Yue-Wen
YW
Fu
Wen-Gang
WG
Liu
Lei
L
Chen
Yan
Y
Wu
D000293:Adolescent; D000328:Adult; D016516:CD4-CD8 Ratio; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000628:therapy*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology; D014182:Transplantation, Autologous
D015850:Interleukin-6; D015375:Receptors, Interleukin-2