Urocortin and cardiovascular protection.
Urocortin and other hypothalamus corticotropin-releasing factor (CRF) polypeptides play biologically diverse roles in the stress, cardiovascular and inflammatory responses by acting on central and peripheral CRF receptors. Urocortin shows a significantly high sequence homology to CRF, and the concurrent expression of type-2 CRF (CRF2) receptors with urocortin in the heart suggests that urocortin may play a physiological role in the cardiac function. Urocortin is thought to be the endogenous agonist producing the cardiovascular actions previously attributed to CRF. This review highlights the current novel findings on the molecular and cellular mechanisms by which urocortin may exert its cardiovascular protective action.
Huang
Yu
Y
Department of Physiology, The Chinese University of Hong Kong, Hong Kong, China. yu-huang@cuhk.edu.hk
Yao
Xiao-qiang
XQ
Lau
Chi-wai
CW
Chan
Yau-chi
YC
Tsang
Suk-ying
SY
Chan
Frankly Leung
FL
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D018019:Receptors, Corticotropin-Releasing Hormone / Q000187:drug effects; D054832:Urocortins; D014665:Vasodilator Agents / Q000494:pharmacology*
D002316:Cardiotonic Agents; D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; D014665:Vasodilator Agents; D003346:Corticotropin-Releasing Hormone