[Study on the clinical value of serum cardiac troponin T in early diagnosing of acute non-Q-wave myocardial infarction and prognostic evaluation].
OBJECTIVE
To investigate the value of serum cardiac troponin T (cTnT) in diagnosing earlier acute non-Q-wave myocardial infarction (NQMI) and judging the prognosis.


METHODS
Seventy-four NQMI patients and 118 Q-wave myocardial infarction (QMI) patients were studied. Serum cTnT and MB isoenzyme of creatine kinase (CK-MB) levels were monitored on fixed time. On the 15th day of hospitalization, 99 mTc-MIBI myocardial single photon emission computed tomography (SPECT) was performed to assess the infarct size index. Clinical informations of the two groups such as cardiac dysfunction, re-infarction, fatal cadiac arrhythmia, sudden death were collected.


RESULTS
The time for serum cTnT beginning to rise was earlier than CK-MB. Its peak time value was paralled to that of CK-MB, and cTnT elevation lasted longer than CK-MB. Serum cTnT and CK-MB peak value showed positive correlation with the infarct size index (both P<0.01). The peak values of cTnT and CK-MB in NQMI group were lower than those in QMI group, and the infarct size was smaller than QMI group (all P<0.05). The frequencies of cardiac events were significantly raised in both groups when there was a high level of serum cTnT. But the proportion in NQMI group was less than those in QMI group (P<0.05). The cardiac events in NQMI group were less than that in QMI group (P<0.05).


CONCLUSIONS
Serum cTnT is an effective marker for diagnosing earlier NQMI, detecting myocardial damage, estimating infarct size and prognosis in the nearly future.
Department of Cardiology, Harrison International Peace Hospital, Hengshui 053000, Hebei, China.
Qun
Q
Zheng
Wei-zhan
WZ
Wang
Ying-xuan
YX
Zhang
Lan
L
Wang
Ling-jun
LJ
Zhao
D000368:Aged; D003402:Creatine Kinase / Q000032:analysis; D052279:Creatine Kinase, MB Form; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D011379:Prognosis; D013997:Time Factors; D020107:Troponin T / Q000097:blood*
D007527:Isoenzymes; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form