Design, synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antifungal and anticancer agents.
A series of 1,4-naphthoquinone derivatives were synthesized and tested for antifungal and antitumor activity against a number of fungal disease causative species and Walker 256 carcinoma cell lines. The results show that the compounds 8a,e and 11b possess pronounced antifungal profile where as 7b and f were found to be active against Walker 256 carcinoma cell lines. Moreover 7c and 11a showed inhibitory effect against reverse transcriptase enzyme from Rauscher Murine Leukemia Virus.
Tandon
Vishnu K
VK
Department of Chemistry, Lucknow University, Lucknow-226001, U. P., India. vishnutandon@rediffmail.com
Chhor
Rakeshwar B
RB
Singh
Ravindra V
RV
Rai
Sanjay
S
Yadav
Dharmendra B
DB
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002279:Carcinoma 256, Walker; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009285:Naphthoquinones; C035342:1,4-naphthoquinone