Fas ligand expression is a risk factor for liver metastasis in colorectal cancer with venous invasion.
The expression of Fas ligand (Fas L) was investigated in sixty-seven patients with colorectal cancer for possible correlation with liver metastasis. Fas L expression was positive in 48 and negative in 19 cases. In Fas L-positive cases, 14 patients had liver metastasis including metachronous metastasis. However, only one case had liver metastasis in Fas L-negative patients (p = 0.0344). In colorectal cancer with venous invasion, 13 from 25 Fas L-positive cases had liver metastasis but only one in 19 negative cases (p = 0.0003). In the cases without venous invasion, no liver metastasis was observed in Fas L-negative cases. These results suggest that Fas L expression may be a predictive factor for liver metastasis in colorectal cancer with venous invasion.
Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishiogu, Arakawaku, Tokyo 116-8563, Japan.
Hajime
H
Yokomizo
Kazuhiko
K
Yoshimatsu
Keiichiro
K
Ishibashi
Masahiko
M
Hashimoto
Kiyohito
K
Yosida
Hiroyuki
H
Kato
Yoshihiko
Y
Naritaka
Yoshiaki
Y
Okada
Kenji
K
Ogawa
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000473:pathology*; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000276:immunology* / Q000556:secondary*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008875:Middle Aged
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins