Thermodynamic phase plane analysis of ventricular contraction and relaxation.
BACKGROUND
Ventricular function has conventionally been characterized using indexes of systolic (contractile) or diastolic (relaxation/stiffness) function. Systolic indexes include maximum elastance or equivalently the end-systolic pressure volume relation and left ventricular ejection fraction. Diastolic indexes include the time constant of isovolumic relaxation - and the end-diastolic pressure-volume relation. Conceptualization of ventricular contraction/relaxation coupling presents a challenge when mechanical events of the cardiac cycle are depicted in conventional pressure, P, or volume, V, terms. Additional conceptual difficulty arises when ventricular/vascular coupling is considered using P, V variables.


METHODS
We introduce the concept of thermodynamic phase-plane, TPP, defined by the PdV and VdP axes.


RESULTS
TPP allows all cardiac mechanical events and their coupling to the vasculature to be geometrically depicted and simultaneously analyzed.


CONCLUSIONS
Conventional systolic and diastolic function indexes are easily recovered and novel indexes of contraction-relaxation coupling are discernible.
Karamanoglu
Mustafa
M
Cardiovascular Biophysics Laboratory, Washington University School of Medicine, Washington University in St Louis, 660 South Euclid Ave, Box 8086, St, Louis, MO 63110, USA. mustafa.karamanoglu@medtronic.com
Kovács
Sándor J
SJ
D000328:Adult; D000368:Aged; D002118:Calcium / Q000378:metabolism; D003971:Diastole / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D008955:Models, Cardiovascular; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology*; D013816:Thermodynamics; D016276:Ventricular Function; D017725:Ventricular Pressure
D002118:Calcium