Terlipressin bolus induces systemic vasoconstriction in septic shock.
OBJECTIVE
To report the use of a synthetic, long-acting, vasopressin analog, terlipressin, as an effective vasoconstrictor in septic shock.


METHODS
Case report.


METHODS
A 22-bed pediatric intensive care unit in a tertiary referral center.


METHODS
An 11-yr-old male with multiple-organism Gram-negative septic shock with high normal cardiac output as assessed by pulse contour analysis and low systemic vascular resistance despite norepinephrine infusion.


METHODS
Two peripherally administered doses of terlipressin (0.5 mg).


RESULTS
Each dose of terlipressin was associated with a rapid increase in systemic vascular resistance, despite weaning and discontinuation of norepinephrine infusion from 0.15 microg.kg(-1).min(-1) lasting approximately 6 hrs.


CONCLUSIONS
Terlipressin may be useful for sepsis-induced vasodilation.
Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Mark J
MJ
Peters
Rachelle A
RA
Booth
Andy J
AJ
Petros
D002648:Child; D004927:Escherichia coli Infections / Q000150:complications; D006801:Humans; D007275:Injections, Intravenous; D007710:Klebsiella Infections / Q000150:complications; D008236:Lypressin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D009638:Norepinephrine / Q000627:therapeutic use; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000077585:Terlipressin; D014655:Vascular Resistance / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin; D009638:Norepinephrine