Effects of simulated microgravity conditions on carrageenin-induced oedema in rat.
The effects of simulated microgravity conditions, using a three-dimensional clinostat (Random Positioning Machine, RPM), on carrageenin-induced paw oedema in rats as a model of local inflammation were evaluated. RPM-exposed animals showed a significant reduction of oedema and a more pronounced decrease in body weight with respect to control groups. Moreover, aspirin (ASA) treatment, an anti-inflammatory agent, on RPM-exposed rats did not exhibit any activity after carrageenin challenge with respect to RPM control animals on the ground. ASA activity on RPM could be prevented by RPM-induced anti-oedematous effect. RPM-induced anti-oedematous effect did not reversed by pre-treatment with the non-selective glucocorticoid receptor antagonist, mifepristone ruling out the supposed influence of an of cortisol release during the RPM treatment.
Peana
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AT
Dipartimento di Scienze del Farmaco, University of Sassari, via Muroni, Italy. apeana@ssmain.uniss.it
Chessa
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ML
Deligios
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M
Cesarone
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CF
Meloni
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MA
Pippia
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