Differential response of linear and angular psoralens in PUVA-induced apoptosis in HL-60 cells.
Treatment of cells with UVA radiation in combination with linear psoralens induces a cell-cycle block and subsequent apoptosis, whereas angular derivatives produce apoptosis without affecting the cellular cycle.
Viola
Giampietro
G
Department of Pharmaceutical Sciences, University of Padua, via Marzolo 5, 35131 Padua, Italy. giampietro.viola.1@unipd.it
Facciolo
Laura
L
Vedaldi
Daniela
D
Disarò
Silvia
S
Basso
Giuseppe
G
Dall'Acqua
Francesco
F
D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D002453:Cell Cycle / Q000187:drug effects; D011564:Furocoumarins / Q000737:chemistry* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D011701:PUVA Therapy; D018462:Photobiology; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
D011564:Furocoumarins; D017319:Photosensitizing Agents