Determining variables for repeat prostate biopsy.
During the evaluation of prostate cancer, men who have undergone transrectal ultrasound-guided biopsy with negative results present a dilemma as to what further follow-up is required. Multiple variables have been proposed throughout the literature to improve cancer detection rates not only in initial biopsy results, but also on repeat evaluation. These variables include prostate-specific antigen (PSA) velocity, PSA density, free-percent PSA, and histological findings, each of which may singly or collectively dictate the need for further biopsy. After performing a Medline literature search using specific Medical Subject Headings (prostate biopsy, repeat prostate biopsy, PSA velocity, PSA density, free-percent PSA, prostate inflammation), we critically evaluated pertinent articles. Using this accumulated data and information, we composed an algorithm to assist in the decision process for repeat biopsy.
Department of Urology, University of California, Davis, Sacramento, California 95817, USA.
J E
JE
Busby
C P
CP
Evans
D000465:Algorithms; D001706:Biopsy / Q000379:methods; D003657:Decision Making; D006801:Humans; D007249:Inflammation; D008297:Male; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D012007:Rectum / Q000000981:diagnostic imaging; D013997:Time Factors; D018084:Ultrasonography, Interventional
D017430:Prostate-Specific Antigen