Differential effects of somatostatin on exploratory behavior after unilateral injections in to rat neostriatum.
The effects of somatostatin (SRIF) microinjected unilaterally (left or right) at a dose of 10, 50, and 100 ng into the neostriatum of male Wistar rats on exploratory behavior were studied. Unilateral injections of SRIF suppressed dose-related the exploratory activity as decreased the number of horizontal and vertical movements compared to the respective controls. The effect was more pronounced when SRIF was microinjected into the right neostriatum as compared to the left neostriatum. These findings suggest some asymmetric effects of SRIF, depending on the dose and the microinjected hemisphere.
Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. roman@bio.bas.bg
Roman
R
Tashev
Stiliana
S
Belcheva
Iren
I
Belcheva
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000494:pharmacology*
D013004:Somatostatin