Evaluation of acute hematologic and long-term pulmonary toxicities of radioimmunotherapy of Cryptococcus neoformans infection in murine models.
We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 microCi were well tolerated by healthy A/JCr mice for (213)Bi-18B7 and (188)Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 microCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA. edadachova@aecom.yu.edu
E
E
Dadachova
R A
RA
Bryan
A
A
Frenkel
T
T
Zhang
C
C
Apostolidis
J S
JS
Nosanchuk
J D
JD
Nosanchuk
A
A
Casadevall
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001729:Bismuth; D001772:Blood Cell Count; D003453:Cryptococcosis / Q000097:blood / Q000532:radiotherapy*; D005260:Female; D005355:Fibrosis; D006402:Hematologic Diseases / Q000097:blood* / Q000209:etiology*; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology*; D051379:Mice; D008805:Mice, Inbred A; D010976:Platelet Count; D016499:Radioimmunotherapy / Q000009:adverse effects*; D011868:Radioisotopes / Q000627:therapeutic use; D012211:Rhenium
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D012211:Rhenium; D001729:Bismuth