Coupling between "hand" primary sensorimotor cortex and lower limb muscles after ulnar nerve surgical transfer in paraplegia.
Previous neuroimaging evidence revealed an "invasion" of "hand" over "lower limb" primary sensorimotor cortex in paraplegic subjects, with the exception of a rare patient who received a surgical motor reinnervation of hip-thigh muscles by the ulnar nerve. Here, the authors show that a functional reorganization of cortico-muscular and cortico-cortical oscillatory coupling was related to the recovery of the rare patient, as a paradigmatic case of long-term plasticity in human sensorimotor cortex after motor reinnervation of paraplegic muscles. This conclusion was based on electroencephalographic and electromyographic data collected while the patient and normal control subjects performed isometric muscle contraction of the left hand or lower limb. Cortico-muscular and cortico-cortical coupling was estimated by electroencephalographic-electromyographic coherence and directed transfer function of a multivariate autoregressive model.
Dipartimento di Fisiologia Umana e Farmacologia, Universita degli Studi di Roma La Sapienza, Rome, Italy. claudio.babiloni@uniromal.it
C
C
Babiloni
F
F
Vecchio
F
F
Babiloni
G A
GA
Brunelli
F
F
Carducci
F
F
Cincotti
V
V
Pizzella
G L
GL
Romani
F T
FT
Tecchio
P M
PM
Rossini
D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography / Q000379:methods; D006225:Hand / Q000502:physiology*; D006801:Humans; D035002:Lower Extremity / Q000502:physiology* / Q000601:surgery; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology / Q000601:surgery; D016067:Nerve Transfer / Q000379:methods; D010264:Paraplegia / Q000503:physiopathology / Q000601:surgery*; D011597:Psychomotor Performance / Q000502:physiology; D014459:Ulnar Nerve / Q000502:physiology / Q000601:surgery*