(+/-)-cis-(6-Ethyl-tetrahydropyran-2-yl)-formic acid: a novel substance with antinociceptive properties.
We described in this paper the first synthesis to the (+/-) cis (6-ethyl-tetrahydropyran-2-yl) formic acid (1) using the very efficient Prins cyclization reaction as strategy to construction of its tetrahydropyran skeleton. This new compound presented a significant antinociceptive property by the tail-flick model.
Miranda
L S M
LS
Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro-UFRJ, CCS, Bloco H, Ilha do Fundão, 21941-590, Rio de Janeiro, Brazil.
Marinho
Bruno G
BG
Leitão
Suzana G
SG
Matheus
Maria Eline
ME
Fernandes
Patrícia D
PD
Vasconcellos
M L A A
ML
D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D005561:Formates / Q000737:chemistry* / Q000494:pharmacology*; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods
D000700:Analgesics; D005561:Formates; C030544:formic acid