[Fermentative hydrolysate of mycelial waste of aminoglycoside antibiotics production as component of culture media used in biosynthesis of tobramycin].
New nutrient media for cultivation of the tobramycin-producing organism were developed. As an additional source of nitrogen the media contain fermentative hydrolysate of the mycelial waste of manufacture of aminoglycoside antibiotics (tobramycin and apramycin). The use of the media provided a 20 to 50% decrease of consumption of soybean meal, an essential food raw material, and design of a low-waste technology for biosynthesis of tobramycin.
Cherkashina
N V
NV
Litusov
N V
NV
Mikhaĭlov
V A
VA
Vasil'ev
P G
PG
Rogozhin
A Z
AZ
Makhortov
V L
VL
Bunakov
Iu P
IuP
Ustinova
N B
NB
Andrus
E A
EA
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D018533:Biomass; D003470:Culture Media / Q000737:chemistry; D004345:Drug Industry; D005285:Fermentation; D006868:Hydrolysis; D025282:Mycelium / Q000378:metabolism*; D013025:Glycine max; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*; D014031:Tobramycin / Q000096:biosynthesis*; D014866:Waste Products
D000900:Anti-Bacterial Agents; D003470:Culture Media; D014866:Waste Products; D014031:Tobramycin