title: Gelatinase B is associated with peri-implant bone loss.
abstract: The aim of this study was to clear whether gelatinase B is associated with peri-implant bone loss (PBL). Peri-implant sulcus fluid was collected from 46 implant sites in 12 patients. These sites were also characterized using modified Gingival Index (mGI). Activated and total gelatinase B levels, measured using a modified urokinase assay, showed correlation with PBL (n = 46, Spearman's rank correlation test). Activated and total gelatinase B values were significantly higher in PBL > 3 mm group (n = 6) compared to PBL < 1 mm (n = 29) and 1 < PBL < 3 mm (n = 11) groups (rank sum test). Activated gelatinase B level in mGI > 0.5 group (n = 24) was clearly higher compared to mGI = 0 (n = 13) and < or = 0.5 (n = 9) groups (Rank sum test). We conclude that gelatinase B is associated with PBL. Activation of gelatinase B together with elevated mGI eventually reflect active phases of peri-implantitis and may prove to be diagnostically useful.
authors.affiliation: Biomedicum/Anatomy, University of Helsinki, Finland.
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Uula
authors.initials: U
authors.lastname: Kitti
authors.forename: Roeland
authors.initials: R
authors.lastname: Hanemaaijer
authors.forename: Olli P
authors.initials: OP
authors.lastname: Teronen
authors.forename: Timo A
authors.initials: TA
authors.lastname: Sorsa
authors.forename: Sirajedin
authors.initials: S
authors.lastname: Natah
authors.forename: Eve-Kai
authors.initials: EK
authors.lastname: Tensing
authors.forename: Yrjö T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000201:enzymology* / Q000209:etiology*; D016723:Bone Remodeling / Q000502:physiology; D003758:Dental Implantation, Endosseous / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects*; D019232:Dental Restoration Failure; D005260:Female; D005883:Gingival Crevicular Fluid / Q000201:enzymology*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D010512:Periodontal Index
chemical_list: D015921:Dental Implants; D020780:Matrix Metalloproteinase 9