Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools.
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which types of genes are controlled by HIF-1, it appears that HIF-1 provides pathological tissues with survival in hypoxic regions or angiogenic activity. Therefore, HIF-1 inhibitors could be useful as therapeutic agents for various diseases associated with the over-activation of HIF-1, such as cancers, cardiovascular remodeling, preeclampsia, and other angiogenesis-related diseases. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.
Park
Jong-Wan
JW
Department of Pharmacology, Seoul National University College of Medicine, Korea.
Chun
Yang-Sook
YS
Kim
Myung-Suk
MS
D000818:Animals; D015536:Down-Regulation / Q000235:genetics / Q000502:physiology; D004358:Drug Therapy / Q000379:methods / Q000639:trends*; D020022:Genetic Predisposition to Disease; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen / Q000378:metabolism; D014157:Transcription Factors / Q000009:adverse effects* / Q000235:genetics / Q000378:metabolism
C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors; D010100:Oxygen