[The expression of cell adhesion molecule Syndecan-1 and E-candherin in laryngeal cancer].
OBJECTIVE
To observe Syndecan-1 and E-candherin expression and their relationship with clinico-pathologic factors in primary laryngeal squamous cell carcinoma(LSCC).


METHODS
Syndecan-1 and E-candherin proteins were determined with immunohistochemical technique.


RESULTS
In invasive LSCC the expression of these two adhesion molecules were very similar. Both diminished with decreasing cell differentiation, lacked often in poorly differentiated tumors. And their expression were significantly correlated with each other.


CONCLUSIONS
Our results suggest that Syndecan-1 and E-candherin expression correlates significantly with the histological differentiation grade of the tumors and the tumors size. They may play important roles in the pathogensis and the development of LSCC.
Li
Yin
Y
Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Yang
Chengzhang
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D005260:Female; D005931:Glottis; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D011379:Prognosis; D011509:Proteoglycans / Q000032:analysis*; D053668:Syndecan-1; D053667:Syndecans
D015820:Cadherins; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans