Socializing with the neighbors: stem cells and their niche.
The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cell niches and their impact on stem cell biology.
Fuchs
Elaine
E
Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA. fuchslb@rockefeller.edu
Tumbar
Tudorita
T
Guasch
Geraldine
G
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D038081:Organogenesis / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism* / Q000648:ultrastructure
D015815:Cell Adhesion Molecules