Radical cystectomy for invasive bladder cancer: results of multi-institutional pooled analysis.
BACKGROUND
We report the outcome of radical cystectomy for patients with invasive bladder cancer, who did not have regional lymph node or distant metastases, at 21 hospitals.


METHODS
Retrospective, non-randomized, multi-institutional pooled data were analyzed to evaluate outcomes of patients who received radical cystectomy. Between 1991 and 1995, 518 patients with invasive bladder cancer were treated with radical cystectomy at 21 hospitals. Of these, 250 patients (48.3%) received some type of neoadjuvant and/or adjuvant therapy depending on the treatment policy of each hospital.


RESULTS
The median follow-up period was 4.4 years, ranging from 0.1 to 11.4 years. The 5-year overall survival rate was 58% for all 518 patients. The 5-year overall survival rates for patients with clinical T2N0M0, T3N0M0 and T4N0M0 were 67%, 52% and 38%, respectively. The patients with pT1 or lower stage, pT2, pT3 and pT4 disease without lymph node metastasis had 5-year overall survivals of 81%, 74%, 47% and 38%, respectively. The patients who were node positive had the worst prognosis, with a 30% overall survival rate at 5 years. Neoadjuvant or adjuvant chemotherapy did not provide a significant survival advantage, although adjuvant chemotherapy improved the 5-year overall survival in patients with pathologically proven lymph node metastasis.


CONCLUSIONS
The current retrospective study showed that radical cystectomy provided an overall survival equivalent to studies reported previously, but surgery alone had no more potential to prolong survival of patients with invasive cancer. Therefore, a large-scale randomized study on adjuvant treatment as well as development of new strategies will be needed to improve the outcome for patients with invasive bladder cancer.
Takahashi
Atsushi
A
Department of Urology, Sapporo Medical University School of Medicine, Japan.
Tsukamoto
Taiji
T
Tobisu
Ken-ichi
K
Shinohara
Nobuo
N
Sato
Kazunari
K
Tomita
Yoshihiko
Y
Komatsubara
Shu-ichi
S
Nishizawa
Osamu
O
Igarashi
Tatsuo
T
Fujimoto
Hiroyuki
H
Nakazawa
Hayakazu
H
Komatsu
Hideki
H
Sugimura
Yoshiki
Y
Ono
Yoshinari
Y
Kuroda
Masao
M
Ogawa
Osamu
O
Hirao
Yoshihiko
Y
Hayashi
Tadashi
T
Tsushima
Tomoyasu
T
Kakehi
Yoshiyuki
Y
Arai
Yoichi
Y
Ueda
Sho-ichi
S
Nakagawa
Masayuki
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*