Involvement of stromal proteoglycans in tumour progression.
Glycosaminoglycans (GAGs) and proteoglycans (PGs) belong to a class of extracellular macromolecules necessary for the growth of any multicellular structures, including tumours. Transformed cells induce stromal reaction either per se or by activation of the mesenchymal cells. Tumour stroma contains several chondroitin sulphate and heparan sulphate proteoglycans. These proteoglycans and their glycosaminoglycan chains modify cell behaviour by interacting with different molecules such as growth factors, cytokines, chemokines, proteinases and their inhibitors. This review describes the main proteoglycans of tumour stoma and discusses their implication in the regulation of the activity of extracellular proteins and peptides.
Wegrowski
Yanusz
Y
Laboratory of Biochemistry, CNRS FRE 2534, Faculty of Medicine, IFR-53, 51095 Reims Cedex, France. yanusz.wegrowski@univ-reims.fr
Maquart
Francois-Xavier
FX
D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D009361:Neoplasm Invasiveness; D011509:Proteoglycans / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism
D006025:Glycosaminoglycans; D011509:Proteoglycans