The vanilloid receptor-1 (TRPV1) is expressed in some rat dorsal horn NK1 cells.
The vanilloid receptor-1 (TRPV1), the capsaicin receptor, a transducer of several nociceptive stimuli, is principally expressed by nociceptive fibers that specifically target supraspinal-projecting neurons expressing the NK1 receptor. TRPV1 is also expressed by intraspinal neurons. Using double immunocytochemistry, we show that 14.2% of these TRPV1 dorsal horn cell bodies also express the NK1 receptor suggesting that endogenous vanilloids may directly modulate second-order ascending neurons.
Doly
Stéphane
S
CNRS UMR 7101, Neurobiologie des Signaux Intercellulaires, Université Pierre et Marie Curie, 7 Quai Saint Bernard Bat A 3em, 75252 Paris, France. stephane.doly@snv.jussieu.fr
Fischer
Jacqueline
J
Conrath
Marie
M
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D020671:Posterior Horn Cells / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D011955:Receptors, Drug / Q000032:analysis / Q000096:biosynthesis*; D018040:Receptors, Neurokinin-1 / Q000032:analysis / Q000096:biosynthesis*
D011955:Receptors, Drug; D018040:Receptors, Neurokinin-1