Positron emission tomography imaging in depression: a neural systems perspective.
PET measures of regional glucose metabolism, although chemically nonspecific, are sensitive indices of brain function in the untreated state and following disparate treatments. The continued development of imaging and multivariate statistical strategies is expected to provide an important perspective toward the full characterization of the depression phenotype at the neural systems level. An additional goal is the development of routine, brain-based clinical algorithms that optimize diagnosis and treatment of individual depressed patients.
Mayberg
Helen S
HS
Department of Psychiatry and Medicine (Neurology), Rotman Research Institute, Baycrest Centre, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada. hmayberg@rotman-baycrest.on.ca
D000928:Antidepressive Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D015928:Cognitive Behavioral Therapy; D003863:Depression / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D011237:Predictive Value of Tests; D013577:Syndrome; D013997:Time Factors; D014055:Tomography, Emission-Computed
D000928:Antidepressive Agents; D015415:Biomarkers