title: Monitoring of nevus density in children as a method to detect shifts in melanoma risk in the population.
abstract: BACKGROUND
  Nevus density in children, a well-known risk factor for malignant melanoma, depends both on constitutional factors and on previous ultraviolet (UV) exposure. Secular trends of childhood UV exposure could thus be indirectly monitored by repeated standardized surveys assessing nevus density in children, such as the "childhood monitoring of nevus density (CMONDE-Study)".
  
  
  METHODS
  Two complete surveys comprising all children at the time of school enrolment were performed in the city and county of Göttingen, Germany, during the years 1999 and 2000. A total of 4252 children with a median age of 6.25 years were examined as part of the mandatory school enrolment health assessment, and complete data were available for 3881 children.
  
  
  RESULTS
  Median nevus density was 5.8/m(2) in the entire study group. The subgroup-specific median increased from "Fitzpatrick skin type" IV to II, but the density was not increased for the type I subgroup. Similarly, nevus density rose with increasing lightness of hair color, but was very low in red-haired individuals. While the number of freckles was also strongly associated with nevus density, the association between iris color and skin reflectance, respectively, was weak. The duration of the additional examination for CMONDE was on average 3-5 min per child.
  
  
  CONCLUSIONS
  We regard CMONDE as a highly feasible surveillance instrument, which should be implemented as an important addition to regular regional or national health reporting.
authors.affiliation: Department of Medical Informatics, Biometry and Epidemiology, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany. annette.pfahlberg@rzmail.uni-erlangen.de
authors.forename: A
authors.initials: A
authors.lastname: Pfahlberg
authors.forename: W
authors.initials: W
authors.lastname: Uter
authors.forename: C
authors.initials: C
authors.lastname: Kraus
authors.forename: W R
authors.initials: WR
authors.lastname: Wienecke
authors.forename: U
authors.initials: U
authors.lastname: Reulbach
authors.forename: K F
authors.initials: KF
authors.lastname: Kölmel
authors.forename: O
authors.initials: O
authors.lastname: Gefeller
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology*; D008548:Melanosis / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D009506:Nevus / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D010858:Pigmentation; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*