[Analysis of anthraquinones in serum and urine after oral administration of semen Cassiae].
OBJECTIVE
To analysie the anthraquinones absorbed into serum by different animals (or human beings) after oral administration of Semen Cassiae.


METHODS
Anthraquinones in serum and urine of rats and urine of healthy men after taking Semen Cassiae orally were detected with HPLC.


RESULTS
Only some of the anthraquinones were absorbed into serum. There were differences in absorption and metabolism of anthraquinones between rats and men and some new anthraquinones were produced in the process.


CONCLUSIONS
Anthraquinones absorbed into serum by the experimental animals or men should become target for researching into active compounds of anthraquinones in Semen Cassiae.
Li
Xu-e
XE
College of Life Science of South China Normal University, Guangzhou 510631, Guangdong, China. lixue@scnu.edu.cn
Ma
Wei
W
Guo
Bao-jiang
BJ
Zeng
Zhi
Z
D000284:Administration, Oral; D000818:Animals; D000880:Anthraquinones / Q000097:blood* / Q000652:urine; D002366:Cassia / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D013045:Species Specificity
D000880:Anthraquinones; D004365:Drugs, Chinese Herbal