title: Differential expression of the nm23 genes in the developing human trophoblast.
abstract: NDP kinases are the non-specific enzymes which catalyse the synthesis of the NTPs through a transfer reaction using ATP as phosphoryl donor. In addition to their enzymatic activity, they display other not yet explained functions related to cell growth, differentiation and apoptosis, embryonic development, tumour progression and metastasis. In this study, the expression patterns of the three highly related NDP kinases A, B and C isoforms were investigated in the developing human trophoblast. Both NDP kinase A and B were found to be primarily present in the villous and extravillous cytotrophoblasts, while NDP kinase C was found almost exclusively in the syncytiotrophoblast layer. This suggests that NDP kinase A and B could be a marker for the mononuclear stage of differentiation of villous trophoblasts, while NDP kinase C could be a marker of the syncytiotrophoblast layer.
authors.affiliation: Biologie de la Différenciation et du Développement, Université Victor Segalen-Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: Guyon
authors.forename: B
authors.initials: B
authors.lastname: Marnet
authors.forename: S
authors.initials: S
authors.lastname: Arnaud-Dabernat
authors.forename: D
authors.initials: D
authors.lastname: Carles
authors.forename: C
authors.initials: C
authors.lastname: Mathieu
authors.forename: R
authors.initials: R
authors.lastname: Saura
authors.forename: Y
authors.initials: Y
authors.lastname: Perel
authors.forename: J
authors.initials: J
authors.lastname: Horovitz
authors.forename: M
authors.initials: M
authors.lastname: Landry
authors.forename: P
authors.initials: P
authors.lastname: Bischof
authors.forename: J Y
authors.initials: JY
authors.lastname: Daniel
mesh_terms: D005314:Embryonic and Fetal Development / Q000502:physiology; D005136:Eye Proteins / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D019394:Ki-67 Antigen / Q000032:analysis; D054778:NM23 Nucleoside Diphosphate Kinases; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009701:Nucleoside-Diphosphate Kinase / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D014327:Trophoblasts / Q000201:enzymology*
chemical_list: D005136:Eye Proteins; D019394:Ki-67 Antigen; C081848:NDP protein, human; D054778:NM23 Nucleoside Diphosphate Kinases; D009419:Nerve Tissue Proteins; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase