title: An introduction to matrikines: extracellular matrix-derived peptides which regulate cell activity. Implication in tumor invasion.
abstract: The term of "matrikines" was coined for designating peptides liberated by partial proteolysis of extracellular matrix macromolecules, which are able to regulate cell activities. Among these peptides, some of them may modulate proliferation, migration, protease production, or apoptosis, which suggest that they can play a significant role in the control of tumor progression. In this introduction, we present the best characterized matrikines, derived from elastin, connective tissue glycoproteins, or collagens.
authors.affiliation: CNRS FRE 2534, Laboratory of Biochemistry and Molecular Biology, IFR 53 "Biomolecules", Faculty of Medicine, 51 rue Cognacq Jay, 51095 Reims Cedex, France. fmaquart@ehu-reims.fr
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Maquart
authors.forename: Sylvie
authors.initials: S
authors.lastname: Pasco
authors.forename: Laurent
authors.initials: L
authors.lastname: Ramont
authors.forename: William
authors.initials: W
authors.lastname: Hornebeck
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Monboisse
mesh_terms: D003238:Connective Tissue / Q000378:metabolism; D004549:Elastin / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D010455:Peptides / Q000378:metabolism*
chemical_list: D006023:Glycoproteins; D010455:Peptides; D004549:Elastin