Extended interval dosing of gentamicin in preterm infants.
Conventional interval dosing (CID) and extended interval dosing (EID) of gentamicin were compared in preterm infants. Gentamicin peak and trough levels, serum creatinine, urine output, and hearing screens were obtained in 40 preterm infants. Results suggest that EID is safe, provides gentamicin levels in desirable ranges (peak, 5 to 12 microg/mL; trough < 2 microg/mL), and reduces dosage adjustments.
Mercado
Ma Cecilia K
MC
Division of Neonatology, Department of Pediatrics, Albert Einstein Medical Center, Philadelphia, Pennsylvania, USA.
Brodsky
Nancy L
NL
McGuire
Michael K
MK
Hurt
Hallam
H
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D008297:Male
D000900:Anti-Bacterial Agents; D005839:Gentamicins