Chaperones: inserting beta barrels into membranes.
How beta-barrel proteins are inserted into cellular membranes is poorly understood. New work has identified a sorting and assembly machinery that chaperones beta-barrels into the mitochondrial outer membrane and is evolutionarily conserved from bacteria to man.
Ryan
Michael T
MT
Department of Biochemistry, La Trobe University 3088, Melbourne, Australia. M.Ryan@latrobe.edu.au
D026901:Membrane Transport Proteins / Q000378:metabolism*; D008566:Membranes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins; C066555:Tom40 protein, S cerevisiae