title: Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa.
abstract: [structure: see text] Four new dolabellane-type diterpene alkaloids, nigellamines A(1) (1), A(2) (2), B(1) (3), and B(2) (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A(1) (1), B(1) (3), and B(2) (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kuoto-phu.ac.jp
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Fengming
authors.initials: F
authors.lastname: Xu
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Kashima
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ninomiya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry*; D022781:Hepatocytes; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D031881:Nigella sativa / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism; D010946:Plants, Medicinal; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000037:antagonists & inhibitors
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D010936:Plant Extracts; D014280:Triglycerides; C115566:dolabellane