title: [Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].
abstract: OBJECTIVE
  To find new active constituents from Rhizome of Cimicifuga foetida.
  
  
  METHODS
  Various column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences.
  
  
  RESULTS
  Four triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4).
  
  
  CONCLUSIONS
  Compound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.
authors.affiliation: Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Zhao
authors.forename: Di-hua
authors.initials: DH
authors.lastname: Chen
authors.forename: Jian-yong
authors.initials: JY
authors.lastname: Si
authors.forename: Rui-le
authors.initials: RL
authors.lastname: Pan
authors.forename: Lian-gang
authors.initials: LG
authors.lastname: Shen
authors.forename: Duo
authors.initials: D
authors.lastname: Chen
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D031885:Cimicifuga / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D018215:Osteoblastoma / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C478830:(23R,24S)-16,23-16,24-diepoxy-9,19-cyclolanostan-3beta,15alpha,25-triol; D014315:Triterpenes; D007810:Lanosterol; C487050:7,8-didehydro-27-deoxyactein