Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines.
Mucosal tissues are the primary site of natural HIV transmission and a major reservoir for HIV replication. Targeting immune responses to the mucosal entry site before viral dissemination could protect and also clear viral reservoirs. Recent understanding of mucosal HIV transmission and of chemokines and integrins in mucosal trafficking can aid design of new strategies to enhance AIDS vaccine efficacy.
Belyakov
Igor M
IM
Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. belyakov@mail.nih.gov
Berzofsky
Jay A
JA
D016915:AIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D002465:Cell Movement; D018925:Chemokines / Q000502:physiology; D006678:HIV / Q000472:pathogenicity; D015483:HIV Antibodies / Q000096:biosynthesis; D015658:HIV Infections / Q000276:immunology* / Q000517:prevention & control; D006801:Humans; D018928:Immunity, Mucosal; D016023:Integrins / Q000502:physiology; D009092:Mucous Membrane / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D016915:AIDS Vaccines; D018925:Chemokines; D015483:HIV Antibodies; D016023:Integrins