Gastrointestinal basic science 2002-2003: the year in review.
The Board of Editors of Gastroenterology identified 6 topics in basic gastroenterology research in which exciting advancements have been made during the past year. These topics are (1) NOD2 variants in Crohn's disease, (2) Heliobacter pylori and CagA and VacA pathogenesis, (3) beta-catenin function in normal colonic epithelia and colon cancer, (4) DNA methylation in colonic cancer, (5) the HCV replicon, and (6) the use of small interfering RNA in somatic cell genetics. Basic research in gastroenterology has been characterized during the past year by the rapid translation from fundamental research into pathophysiological systems. New technological advances are being applied to difficult areas of gastrointestinal research. Well-defined patient populations are critical to extend the knowledge derived from the human genome to gastrointestinal diseases.
Brenner
David A
DA
College of Physicians and Surgeons, Columbia University, 622 West 168th Street, PH 8E-105J, New York, New York 10032, USA. dab2106@columbia.edu
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics / Q000503:physiopathology; D003424:Crohn Disease / Q000235:genetics; D003598:Cytoskeletal Proteins / Q000502:physiology; D019175:DNA Methylation; D005767:Gastrointestinal Diseases / Q000235:genetics / Q000503:physiopathology; D018390:Gene Targeting; D006526:Hepatitis C / Q000235:genetics / Q000503:physiopathology / Q000821:virology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009154:Mutation / Q000235:genetics; D053473:Nod2 Signaling Adaptor Protein; D034741:RNA, Small Interfering / Q000235:genetics; D012093:Replicon / Q000502:physiology; D012586:Science; D015534:Trans-Activators / Q000502:physiology; D051176:beta Catenin
C495270:CTNNB1 protein, human; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D034741:RNA, Small Interfering; D015534:Trans-Activators; D051176:beta Catenin