A rapid presentation event-related functional magnetic resonance imaging study of response inhibition in macaque monkeys.
Rapid presentation event-related functional magnetic resonance imaging was applied to macaque monkeys performing a symmetrically rewarded go/no-go task, to investigate neural correlate of response inhibition. Sensorimotor activation related to the task performance was observed predominantly in the hemisphere contralateral to the response forelimb. Furthermore, no-go dominant activation possibly related to response inhibition, was observed in the ventral prefrontal cortex, in accordance with previous electrophysiological studies. These results show the feasibility of rapid presentation event-related functional magnetic resonance imaging in behaving monkeys.
Morita
Masahito
M
Department of Physiology, The University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Nakahara
Kiyoshi
K
Hayashi
Toshihiro
T
D000704:Analysis of Variance; D000818:Animals; D001931:Brain Mapping; D005071:Evoked Potentials / Q000502:physiology*; D007839:Functional Laterality; D008251:Macaca; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000098:blood supply / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D012201:Reward; D013997:Time Factors
D010100:Oxygen