Synthesis and anti-inflammatory activity of some [4,6-(4-substituted aryl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetic acid derivatives.
A series of [4,6-(substituted aryl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetic acid (4a-r) has been synthesized by the base catalyzed condensation of beta-aroylpropionic acid, thiourea with aldehyde in ethanol. Structures of the new compound were established on the basis of (1)H NMR and IR spectral data. Anti-inflammatory activity in vivo were evaluated and compared with standard drug diclofenac sodium. Some compounds have shown moderate activity.
Bahekar
Sushilkumar S
SS
Department of Chemical Technology, Dr Babasaheb Ambedkar Marathwada University, Aurangabad-431 004, MS India.
Shinde
Devanand B
DB
D000085:Acetates / Q000138:chemical synthesis* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D051381:Rats
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011743:Pyrimidines