title: [Concentration and antiviral activity of interferon-alpha in the sera of patient with hepatic pathology].
abstract: The normalization of the antiviral activity of interferon-alpha (IFN-alpha) in the process of the treatment of patients with acute viral hepatitis (VH), simultaneously with the results of other clinico-laboratory tests, reflects the positive dynamics of the process. The prolonged preservation of the elevated level of the antiviral activity of IFN-alpha (up to 6 months and longer) is a prognostically unfavorable sign. In patients with chronic VH the growth of both the average concentration of IFN-alpha in the blood serum and its average antiviral activity can be observed. With the progress of the disease and the formation of the cirrhosis of the liver, the concentration of IFN-alpha in the blood serum remains to be elevated, while its antiviral activity drops.
authors.affiliation: Gabrichevsky Research Institute of Epidemiology and Microbiology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Astakhin
authors.forename: B N
authors.initials: BN
authors.lastname: Levitan
authors.forename: S S
authors.initials: SS
authors.lastname: Afanas'ev
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'ev
authors.forename: V A
authors.initials: VA
authors.lastname: Aleshkin
authors.forename: L A
authors.initials: LA
authors.lastname: Denisov
authors.forename: E M
authors.initials: EM
authors.lastname: Chishieva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000097:blood / Q000494:pharmacology*; D018450:Disease Progression; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood* / Q000175:diagnosis; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D016898:Interferon-alpha / Q000097:blood / Q000494:pharmacology*; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha