Solubility enhancement of celecoxib using beta-cyclodextrin inclusion complexes.
Celecoxib has very low water solubility. It forms a complex with beta-cyclodextrin (betaCD) both in aqueous and in solid state. It was observed that due to formation of the inclusion complex, the solubility and dissolution rate of celecoxib were enhanced. The formation of 1:1 complex with betaCD in solution was confirmed by phase solubility and spectral shift studies. The apparent stability constants calculated by these techniques were 881.5 and 341.5 M(-1), respectively. The solid inclusion complexes of celecoxib and betaCD were prepared by the kneading method using different molar proportions of betaCD, and formation of solid inclusion complexes of celecoxib and betaCD at different molar ratios were confirmed by differential scanning calorimetry. Enhancement of dissolution rates with increasing quantity of betaCD in the complex was observed. It was also observed that the complexes exhibit higher dissolution rates than the pure drug and physical mixture.
Rawat
Swati
S
YB Chavan College of Pharmacy, Rouza Bagh, Aurangabad, MS, India. swati@k.st
Jain
Sanjay K
SK
D000068579:Celecoxib; D003505:Cyclodextrins / Q000737:chemistry* / Q000493:pharmacokinetics; D011720:Pyrazoles; D012995:Solubility / Q000187:drug effects; D013449:Sulfonamides / Q000737:chemistry* / Q000493:pharmacokinetics; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D011720:Pyrazoles; D013449:Sulfonamides; D047392:beta-Cyclodextrins; D000068579:Celecoxib; C031215:betadex