Development of IgA nephritis following cat scratch disease in a 13-year-old boy.
We describe a 13-year-old boy who presented with hematuria and intermittent low-grade proteinuria at the time when he was diagnosed with cat scratch disease. Two months before presentation, he had a negative urinalysis during a routine physical evaluation. He continued to have microscopic hematuria for the next 6 months, when he developed gross hematuria and recurrence of low-grade proteinuria. The renal biopsy showed evidence of mild/moderate IgA nephropathy. We speculate that the immunological changes associated with cat scratch disease in this patient may have triggered the development of IgA nephropathy. A history or serological evidence of infection with Bartonella henselae may need to be sought in patients presenting with IgA nephritis.
Hopp
Laszlo
L
Department of Pediatrics, Division of Nephrology, A.I. duPont Hospital for Children, 1600 Rockland Road, P.O. Box 269, Wilmington, DE 19899, USA. Lhopp@nemours.org
Eppes
Stephen C
SC
D000293:Adolescent; D002372:Cat-Scratch Disease / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D005922:Glomerulonephritis, IGA / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D046529:Microscopy, Electron, Transmission; D011507:Proteinuria / Q000209:etiology