[Necrolytic migratory erythema revealing glucagonoma without diabetes].
We report a case of glucagonoma syndrome, revealed by a necrolytic migratory erythema that had developed for four Years, associated with anorexia, severe weight loss, anemia, hypoprotidemia, and hypoaminoacidemia. The fasting blood glucose level tended paradoxically to be low (0.6 g/l). Elevated plasma glucagon levels confirmed our diagnosis. The absence of diabetes was explained by an independent insulin secretion derived from this composite pancreatic tumor, authenticated by the histological analysis and the proinsulin level. This level was similar to those typically observed in insulinomas. Six Months after a complete surgical exeresis, symptoms disappeared and biological results returned to normal values.
Marty
Cécile
C
Service de Dermatologie, CHU Purpan, place du Docteur-Baylac, TSA 40031, 31059 Toulouse Cedex 9. cecile-marty@caramail.com
Bennet
Antoine
A
Bayle
Paule
P
Danjoux
Marie
M
Lalande
Thibaud
T
Marguery
Marie-Claude
MC
Bazex
Jacques
J
D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D004890:Erythema / Q000209:etiology* / Q000473:pathology; D005500:Follow-Up Studies; D005934:Glucagon / Q000097:blood; D005935:Glucagonoma / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D009336:Necrosis; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012867:Skin / Q000473:pathology; D013577:Syndrome; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon