title: Noradrenaline levels rise significantly in rat arterial grafts at 6 hours postoperatively, and take 48 hours to come down.
abstract: The aim of this study was to investigate the rate of disappearance of noradrenaline in arterial grafts after their transplanation. Arterial grafts were harvested from AO/Ks:OC strain rats. In each rat, a graft was harvested from the femoral artery and transplanted into the common carotid artery. A contralateral unoperated femoral artery served as control. High-performance liquid chromatography (HPLC) with electrochemical detection was used to determine the noradrenaline content in grafts and controls. Immediately after grafting, the noradrenaline content was 76% of control value, at 6 h 130% of control value, and at 48 h 4% of control value. The drop in graft noradrenaline content (from 0-48 h) was statistically significant (P = 0.005). The difference between 0-h, 12-h, and 24-h groups was statistically insignificant. Compared to control specimens, grafts contained less noradrenaline after 12 h, and it disappeared almost completely from femoral arterial grafts in rats within 48 h.
authors.affiliation: Department of Oral and Maxillofacial Diseases, Surgical Hospital Helsinki, University Central Hospital, Helsinki, Finland. heikki.penttila@hus.fi
authors.forename: Heikki
authors.initials: H
authors.lastname: Penttilä
authors.forename: Pirkko
authors.initials: P
authors.lastname: Huttunen
authors.forename: Karl
authors.initials: K
authors.lastname: Von Smitten
authors.forename: Timo
authors.initials: T
authors.lastname: Waris
authors.forename: Nureddin
authors.initials: N
authors.lastname: Ashammakhi
mesh_terms: D000818:Animals; D017536:Carotid Artery, Common / Q000601:surgery*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005263:Femoral Artery / Q000378:metabolism / Q000637:transplantation*; D009638:Norepinephrine / Q000378:metabolism*; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009638:Norepinephrine