The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.
It is known that reactive oxygen species have toxicity to the cochlea. We investigated the effect of edaravone, a free radical scavenger for clinical use, on the cochleae of guinea pigs subjected to acoustic trauma. We assessed auditory brainstem response (ABR) thresholds to evaluate cochlear function and observed the sensory epithelium. After noise exposure (130 dB SPL, 3 h), we observed that the auditory brainstem response threshold shift in edaravone-treated ears was significantly less than that in untreated ears. This result suggests that edaravone protected the cochleae from acoustic trauma.
Takemoto
Tsuyoshi
T
Department of Otolaryngology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan.
Sugahara
Kazuma
K
Okuda
Takeshi
T
Shimogori
Hiroaki
H
Yamashita
Hiroshi
H
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003051:Cochlea / Q000293:injuries* / Q000473:pathology; D004343:Drug Implants; D000077553:Edaravone; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000293:injuries* / Q000473:pathology; D018072:Hair Cells, Auditory, Outer / Q000293:injuries / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000517:prevention & control*; D009622:Noise / Q000009:adverse effects; D009925:Organ of Corti / Q000473:pathology
D004343:Drug Implants; D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine