A novel phase-switching protecting group for multi-step parallel solution phase synthesis.
A new phase-tag 1 which facilitates the parallel solution phase synthesis of carboxylic acids, esters, and carboxamides is reported. The new phase tag assists compound purification by enabling the selective resin capture of reaction products in either a reversible pH dependent manner (solid-phase extraction), or irreversibly in a Diels-Alder reaction.
Li
Xin
X
GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
Abell
Chris
C
Congreve
Miles S
MS
Warrington
Brian H
BH
Ladlow
Mark
M