Role of the cytoskeleton during leukocyte responses.
The cytoskeleton is a cellular network of structural, adaptor and signalling molecules that regulates most cellular functions that are related to the immune response, including migration, extravasation, antien recognition, activation and phagocytosis by different subsets of leukocytes. Recently, a large number of regulatory elements and structural constituents of the leukocyte cytoskeleton have been identified. In this review, we discuss the composition and regulation of the different cytoskeletal elements and their role in immune responses.
Vicente-Manzanares
Miguel
M
Servicio de Inmunología, Hospital Universitario de la Princesa, c/Diego de León 62, 28006-Madrid, Spain.
Sánchez-Madrid
Francisco
F
D008841:Actin Cytoskeleton / Q000276:immunology; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D003599:Cytoskeleton / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D020741:rho GTP-Binding Proteins / Q000276:immunology
D020741:rho GTP-Binding Proteins