[Study of free-radical processes and antioxidant defense parameters during hirudotherapy of patients with diseases of salivary glands].
Hirudotherapy was used in the treatment of 39 patients (10 male and 29 female) aged 28-58 years with chronic sialadenitis and sialadenosis. Control group consisted of 15 normal subjects without diseases of salivary glands. Lipid peroxidation (LPO) and antioxidant defense (AOD) parameters were under study. Hirudotherapy led to improvement of the clinical status in the majority of patients with sialadenosis; the content of superoxide dismutase (SOD) normalized and ceruloplasmin (CP) level increased. The status of patients with sialadenitis also improved; catalase and glutathione peroxidase levels normalized and SOD and CP levels increased. The best therapeutic effect was attained in patients with sialadenitis. No appreciable improvement was observed in patients with chronic parenchymatous parotitis in the presence of Sjogren's syndrome.
Abal'masov
D V
DV
Pozharitskaia
M M
MM
Starosel'tseva
L K
LK
Afanas'ev
V V
VV
D000328:Adult; D002570:Ceruloplasmin / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D006801:Humans; D024763:Leeching; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D010544:Peroxidases / Q000097:blood; D012466:Salivary Gland Diseases / Q000201:enzymology / Q000378:metabolism* / Q000628:therapy*; D012793:Sialadenitis / Q000201:enzymology / Q000378:metabolism / Q000628:therapy; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
D008315:Malondialdehyde; D010544:Peroxidases; D013482:Superoxide Dismutase; D002570:Ceruloplasmin