title: [Soluble HLA class I and HLA class II antigens in the blood of HIV infected patients].
abstract: The levels of HLA, class I, antigen and HLA-DR antigen in the blood sera of HIV-infected persons were determined by the enzyme immunoassay. The levels of soluble antigens HLR-DR and of HLA, class I, in serum samples containing only antibodies to HIV were elevated, respectively, 1.8- and 1.3-fold in comparison with the norm. The level of soluble HLA-DR antigen in samples containing the markers of other infections (HBsAg, antibodies to hepatitis C virus, anti-IgM antibodies to cytomegalovirus) was significantly higher in comparison with samples containing only antibodies to HIV and serum samples from healthy donors (p < 0.05). The concentration of soluble HLA antigen, class I, in the samples containing antibodies to HIV and markers of other infections was also elevated, but the statistically authentic increase in comparison with the normal level was observed only in the presence of the markers of HIV infection, hepatitis C and cytomegalovirus infection.
authors.affiliation: Blokhina Research Institute of Epidemiology and Microbiology, Lobachevsky State University, Nizhny Novgorod, Russia.
authors.forename: N E
authors.initials: NE
authors.lastname: Khudiakova
authors.forename: V V
authors.initials: VV
authors.lastname: Novikov
authors.forename: G A
authors.initials: GA
authors.lastname: Kravchenko
authors.forename: N I
authors.initials: NI
authors.lastname: Ivanova
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Ptitsyna
authors.forename: N N
authors.initials: NN
authors.lastname: Nosov
mesh_terms: D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006684:HLA-DR Antigens / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000150:complications; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D000949:Histocompatibility Antigens Class II / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D012995:Solubility
chemical_list: D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II