title: Isolation and anticomplement activity of compounds from Dendropanax morbifera.
abstract: Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrhea. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. Of these, compound 1 showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98 microM, whereas compounds 2-7 were inactive.
authors.affiliation: Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600, South Korea.
authors.forename: Bo-Young
authors.initials: BY
authors.lastname: Park
authors.forename: Byung-Sun
authors.initials: BS
authors.lastname: Min
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Kim
authors.forename: Dong-Hee
authors.initials: DH
authors.lastname: Kim
authors.forename: Ki-Hwan
authors.initials: KH
authors.lastname: Bae
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Lee
mesh_terms: D027481:Araliaceae; D003169:Complement Inactivator Proteins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves
chemical_list: D003169:Complement Inactivator Proteins; D010936:Plant Extracts; C012749:anticomplement