title: Total synthesis of (+/-)-kalihinol C.
abstract: The total synthesis of kalihinol C, a bis-isonitrile marine diterpenoid isolated from Acanthella sp., is reported. The decalin framework was established via an intramolecular Diels-Alder cycloaddition and subsequently functionalized through a series of substrate-controlled diastereoselective transformations to install the tertiary isonitrile, beta-hydroxy isonitrile, and pendant tetrahydrofuranyl ring.
authors.affiliation: Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: White
authors.forename: Gregg F
authors.initials: GF
authors.lastname: Keaney
authors.forename: Corin D
authors.initials: CD
authors.lastname: Slown
authors.forename: John L
authors.initials: JL
authors.lastname: Wood
mesh_terms: D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000962:Antimalarials; D004224:Diterpenes; D009570:Nitriles; C431469:kalihinane; C484758:kalihinol C