title: AgNOR counts are not altered in alcoholic cirrhosis.
abstract: One hundred and two liver biopsy specimens were stained for Argyrophilic nucleolar organizer regions and associated proteins to assess its utility in differentiating normal, cirrhotic and neoplastic liver tissue. A statistically significant (p < 0.001) difference was observed between mean AgNOR counts of normal (1.53 +/- 0.4), post-hepatitic cirrhosis (3.65 +/- 0.53) and hepatocellular carcinoma (7.94 +/- 1.18). In contrast the mean AgNOR count of biopsies with alcoholic cirrhosis (1.57 +/- 0.06) was significantly less (p < 0.001) than post-hepatitic cirrhosis and was similar to that of normal liver tissue. It is concluded that AgNORs can act as a good adjuvant to histology in diagnosing liver diseases especially in differentiating post-hepatitic and alcoholic cirrhosis.
authors.affiliation: Department of Pathology, M.L.N. Medical College, Allahabad. spmisra@sancharnet.in
authors.forename: Vatsala
authors.initials: V
authors.lastname: Misra
authors.forename: S P
authors.initials: SP
authors.lastname: Misra
authors.forename: Manisha
authors.initials: M
authors.lastname: Dwivedi
authors.forename: Suresh C
authors.initials: SC
authors.lastname: Gupta
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology; D016022:Case-Control Studies; D006505:Hepatitis / Q000150:complications; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000473:pathology; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology; D009697:Nucleolus Organizer Region / Q000473:pathology*; D012834:Silver; D013194:Staining and Labeling
chemical_list: D012834:Silver