Antibacterial activity of ent-kaurene diterpenoids from Rabdosia rosthornii.
Biological activities of ent-kaurene diterpenoids, rosthornins A-D, isolated from the ether extract of the dried leaves of Rabdosia rosthornii (Diels) Hara (Labiatae) were tested. They exhibited antibacterial activity specifically against Gram-positive bacteria, among which Propionibacterium acnes was noted to be the most susceptible.
Kubo
Isao
I
Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA. ikubo@iclink.berkeley.edu
Xu
Yunlong
Y
Shimizu
Kuniyoshi
K
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D037602:Isodon; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011425:Propionibacterium acnes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D045786:Diterpenes, Kaurane; D010936:Plant Extracts