Antidiabetic drugs of plant origin used in China: compositions, pharmacology, and hypoglycemic mechanisms.
The paper reviewed compositions and pharmacological effects of eight antidiabetic herbal drugs that have been approved by health regulatory agency for commercial use in China. Investigators attributed the hypoglycemic effect of these products to their ability to restore the functions of pancreatic tissues and cause an increase in insulin output, to inhibit the intestinal absorption of glucose, or to the facilitation of metabolites in insulin-dependent processes. Treatment with herbal drugs has an effect on protecting beta cells and smoothing out fluctuations in glucose levels. The use of these naturally derived agents in conjunction with conventional drug treatments such as an chemical agent or insulin permits the use of lower doses of the drug and/or decreased frequency of administration which decreases the side effects most commonly observed.
Jia
Wei
W
School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200030, China. weijia@mail.sjtu.edu.cn
Gao
Wen-yuan
WY
Xiao
Pei-gen
PG
D000818:Animals; D027883:Astragalus Plant / Q000737:chemistry; D027885:Astragalus propinquus; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007333:Insulin Resistance; D005894:Panax / Q000737:chemistry; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D032267:Rehmannia / Q000737:chemistry
D001786:Blood Glucose; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; C027492:Huang Qi