title: [Biventricular MR volumetric analysis and MR flow quantification in the ascending aorta and pulmonary trunk for quantification of valvular regurgitation].
abstract: OBJECTIVE
  To test the value of biventricular volumetric analysis and the combination of biventricular volumetric analysis with flow quantification in the ascending aorta (Ao) and pulmonary trunk (Pu) for quantification of regurgitation volume and cardiac function in valvular regurgitation (VR) according to location and presence of single or multivalvular disease.
  
  
  METHODS
  In 106 patients, the stroke volumes were assessed by measuring the biventricular volumes and the forward-stroke volumes in the great and small circulation by measuring the flow in the Ao and Pu. Valve regurgitation volumes and quotients were calculated for single and multivalvular disease and correlated with semiquantitative 2D-echocardiography (grade I-IV). For the assessment of the cardiac function in VR, the volumetric parameters of ejection fraction and end-diastolic (EDV) and end-systolic (ESV) volumes were determined.
  
  
  RESULTS
  The detection rate was 49% for left ventricular (LV) VR and 42% for right ventricular (RV) VR. Low LV VR and RV VR usually could not be detected quantitatively, with the detection rate improving with echocardiographically higher insufficiency grades. Quantitative MRI could detect a higher grade solitary aortic valve insufficiency (> or = 2) in 11 of 12 patients and higher grade mitral valve insufficiency in 4 of 10 patients. A significant increase in RV and LV ventricular EDV and ESV was seen more often with increased MR regurgitation volumes. Aortic stenosis did not interfere with flow measurements in the Ao.
  
  
  CONCLUSIONS
  Biventricular volumetry combined with flow measurements in Ao and Pu is a robust, applicable and simple method to assess higher grade regurgitation volumes and the cardiac function in single and multivalvular regurgitation at different locations. It is an important application for the diagnosis of VR by MRI.
authors.affiliation: Abteilung Strahlendiagnostik, Philipps-Universität Marburg, Marburg. Rominger@med.uni-marburg.de
authors.forename: M B
authors.initials: MB
authors.lastname: Rominger
authors.forename: A
authors.initials: A
authors.lastname: Kluge
authors.forename: G F
authors.initials: GF
authors.lastname: Bachmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001011:Aorta / Q000502:physiology*; D001022:Aortic Valve Insufficiency / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D001783:Blood Flow Velocity; D002306:Cardiac Volume; D003327:Coronary Disease / Q000150:complications; D003971:Diastole; D004452:Echocardiography; D005260:Female; D016027:Heart Transplantation; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D011651:Pulmonary Artery / Q000502:physiology*; D013318:Stroke Volume; D013599:Systole; D014262:Tricuspid Valve Insufficiency / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery