Primary non-Hodgkin's lymphoma of the sinonasal tract.
OBJECTIVE
We sought to review the records of patients seen at the Chaim Sheba Medical Center (Tel Hashomer, Israel) during a 10-year period with respect to the presenting features, management, and outcome of extranodal non-Hodgkin's lymphoma (NHL) of the sinonasal region.


METHODS
Eight patients were diagnosed with NHL of the paranasal sinuses from 1993 to 2003. The data were reviewed, and we noted the patient's age, sex, the presenting signs and symptoms, staging, histology, treatment, and outcome of NHL.


RESULTS
The mean age was 61.75 years (range, 24-83 years), with a 1:1 male-to-female ratio. All cases involved the paranasal sinuses, and the most common symptom was nasal obstruction (6 patients). All the patients had large B-cell lymphoma, and all were treated with combined chemotherapy and radiation. Three patients died from the disease, 3 were free of disease after 12 to 36 months of follow-up, and 1 had a recurrence after 60 months.


CONCLUSIONS
NHLs of the paranasal sinuses are uncommon. Early diagnosis and combined treatment are essential for achieving an optimal outcome.
Shohat
Izhar
I
Department of Oral and Maxillofacial Surgery, Chaim Sheba Medical Center, Tel Hashomer, Israel. izhar123@netvision.net.il
Berkowicz
Miriam
M
Dori
Shai
S
Horowitz
Zeev
Z
Wolf
Michael
M
Taicher
Shlomo
S
Talmi
Yoav P
YP
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004844:Epistaxis / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007557:Israel / Q000453:epidemiology; D016393:Lymphoma, B-Cell / Q000453:epidemiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000453:epidemiology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate