Hydrophobicity analysis of protein primary structures to identify helical regions.
OBJECTIVE
A wavelet based approach for the hydrophobicity analysis of protein primary structures is proposed to predict the presence of alpha helices in the secondary structure.


METHODS
The information about hydropathy profile periodicity content together with a score of probability of occurrence of a single amino acid allows the localization of alpha helices.


RESULTS
The accuracy is comparable to other consolidated predictors based on different techniques (i.e.: neural networks, hidden markov models).


CONCLUSIONS
This method is particularly suitable to capture the amphiphilic character of the helical structures.
Pattini
L
L
Department of Biomedical Engineering, Polytechnic University of Milan, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. pattini@biomed.polimi.it
Cerutti
S
S
D000595:Amino Acid Sequence; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D021621:Imaging, Three-Dimensional; D008962:Models, Theoretical; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted
D011506:Proteins