title: Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.
abstract: Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. anandan.palani@spcorp.com
authors.forename: Anandan
authors.initials: A
authors.lastname: Palani
authors.forename: Sundeep
authors.initials: S
authors.lastname: Dugar
authors.forename: John W
authors.initials: JW
authors.lastname: Clader
authors.forename: William J
authors.initials: WJ
authors.lastname: Greenlee
authors.forename: Vilma
authors.initials: V
authors.lastname: Ruperto
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Duffy
authors.forename: Jean E
authors.initials: JE
authors.lastname: Lachowicz
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D006801:Humans; D018727:Muscarinic Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D043585:Receptor, Muscarinic M2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*
chemical_list: D000577:Amides; D018727:Muscarinic Antagonists; D043585:Receptor, Muscarinic M2