title: 1H NMR relaxation times of skeletal muscle metabolites at 3 T.
abstract: This study reports proton relaxation times of water and metabolites in soleus and tibialis anterior muscles of young healthy volunteers at 3 T. The results are in agreement with data reported for 1.5 and 4 T, showing a steady increase of spin-lattice relaxation times of water, creatine and lipids with B(0) and no effect of B(0) on spin-spin relaxation. Comparison between muscles revealed a longer spin-spin relaxation time of water in soleus than in tibialis anterior muscle (31+/-1 ms vs. 28+/-1 ms, p<0.05). These data can be applied to relaxation correction for the absolute quantification of skeletal muscle metabolite concentrations and further sequence optimization.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine 3, University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. martin.krssak@univie.ac.at
authors.forename: M
authors.initials: M
authors.lastname: Krssák
authors.forename: V
authors.initials: V
authors.lastname: Mlynárik
authors.forename: M
authors.initials: M
authors.lastname: Meyerspeer
authors.forename: E
authors.initials: E
authors.lastname: Moser
authors.forename: M
authors.initials: M
authors.lastname: Roden
mesh_terms: D000328:Adult; D000842:Ankle / Q000502:physiology; D003401:Creatine / Q000032:analysis / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D011522:Protons
chemical_list: D008055:Lipids; D011522:Protons; D003401:Creatine