Trisomy 4 as the sole karyotypic abnormality in a case of acute biphenotypic leukemia with T-lineage markers in minimally differentiated acute myelocytic leukemia.
We report an unusual case of acute biphenotypic leukemia with trisomy 4. A 22-year-old woman presented with acute leukemia characterized by the presence of two cell populations (prothymocytic and myeloblastic). The leukemic cells were resistant to standard induction chemotherapy and were cleared from the bone marrow only after a salvage chemotherapy regimen. To our knowledge, this is the fourth reported case of acute biphenotypic leukemia with trisomy 4 and perhaps the first case with T-lineage markers and acute myelocytic leukemia.
Al-Qurashi
Fat-hia
FH
Department of Oncology, King Faisal Specialist Hospital & Research Center, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia.
Owaidah
Tarek
T
Iqbal
Mohammed A
MA
Aljurf
Mahmoud
M
D000328:Adult; D015415:Biomarkers; D002454:Cell Differentiation; D019070:Cell Lineage; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D014314:Trisomy
D015415:Biomarkers