title: [Experimental study of abnormal cell proliferation and differentiation in rat tongue carcinogenesis induced by 4NQO].
abstract: OBJECTIVE
  To clarify the phenotypic characteristics of abnormal cell proliferation and differentiation in oral carcinogenesis.
  
  
  METHODS
  The expressions of gp230, a marker of epithelium cell differentiation, and proliferating cell nuclear antigen (PCNA) in rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide (4NQO) were detected by LSAB immunohistochemical staining.
  
  
  RESULTS
  With the progress of oral carcinogenesis abnormal proliferation and differentiation patterns were indicated by reduced expression of gp230 and increased expression of PCNA.
  
  
  CONCLUSIONS
  Oral carcinogenesis is the result of mucosa epithelium cell aberrant proliferation and differentiation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Ninth People's Hospital, Shanghai Second Medical University. Shanghai 200011, China.
authors.forename: X K
authors.initials: XK
authors.lastname: Liu
authors.forename: R G
authors.initials: RG
authors.lastname: He
authors.forename: W T
authors.initials: WT
authors.lastname: Chen
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Zhang
authors.forename: C T
authors.initials: CT
authors.lastname: Zhou
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhou