title: Prevention of adhesion formation to polypropylene mesh by collagen coating: a randomized controlled study in a rat model of ventral hernia repair.
abstract: BACKGROUND
  In laparoscopic incisional hernia repair with intraperitoneal mesh, concern exists about the development of adhesions between bowel and mesh, predisposing to intestinal obstruction and enterocutaneous fistulas. The aim of this study was to assess whether the addition of a collagen coating on the visceral side of a polypropylene mesh can prevent adhesion formation to the mesh.
  
  
  METHODS
  In 58 rats, a defect in the muscular abdominal wall was created, and a mesh was fixed intraperitoneally to cover the defect. Rats were divided in two groups; polypropylene mesh (control group) and polypropylene mesh with collagen coating (Parieten mesh). Seven and 30 days postoperatively, adhesions and amount and strength of mesh incorporation were assessed. Wound healing was studied by microscopy.
  
  
  RESULTS
  With Parieten mesh, the mesh surface covered by adhesions was reduced after 30 days (42% vs 69%, p = 0.01), but infection rate was increased after both 7 (p = 0.001) and 30 days (p = 0.03), compared to the polypropylene group with no mesh infections. If animals with mesh infection were excluded in the analysis, the mesh surface covered by adhesions was reduced after 7 days (21% vs 76%, p = 0.02), as well as after 30 days (21 vs 69%, p < 0.001). Percentage of mesh incorporation was comparable in both groups. Mean tensile strength of mesh incorporation after 30 days was higher with Parieten mesh.
  
  
  CONCLUSIONS
  Although the coated Parieten mesh was more susceptible to mesh infection in the current model, a significant reduction of adhesion formation was still seen with the Parieten mesh after 30 days, with comparable mesh incorporation in the abdominal wall.
authors.affiliation: Department of General Surgery, Erasmus University Medical Centre Rotterdam-Dijkzigt, Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: van't Riet
authors.forename: J W A
authors.initials: JW
authors.lastname: Burger
authors.forename: F
authors.initials: F
authors.lastname: Bonthuis
authors.forename: J
authors.initials: J
authors.lastname: Jeekel
authors.forename: H J
authors.initials: HJ
authors.lastname: Bonjer
mesh_terms: D034861:Abdominal Wall / Q000601:surgery; D000818:Animals; D020099:Coated Materials, Biocompatible; D006555:Hernia, Ventral / Q000601:surgery*; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D011126:Polypropylenes; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh; D013718:Tensile Strength; D000267:Tissue Adhesions / Q000517:prevention & control*; D014945:Wound Healing
chemical_list: D020099:Coated Materials, Biocompatible; D011126:Polypropylenes