Chemokines in Kawasaki disease: measurement of CCL2, CCL22 and CXCL10.
Kawasaki disease (KD) is a childhood-onset vascular disease. In order to determine whether KD is associated with altered chemokine production, we measured CCL2, CCL22, and CXCL10 levels in the serum of KD patients and healthy control subjects. The mean serum concentration of CCL2 in KD subjects was 829.0 +/- 388.2 pg/ml, significantly higher than that seen in healthy controls (223.4 +/- 92.6 pg/ml; p < 0.001). In addition, the mean serum CXCL10 level in KD subjects was 2,469.4 +/- 998.8 pg/ml, again significantly higher than that in healthy controls (127.7 +/- 64.2 pg/ml; p < 0.001). No difference was observed in serum concentrations of CCL22 between KD and healthy controls (1,685 +/- 1,985 microg/ml and 1,539 +/- 380 microg/ml, respectively). Thus, we observed the selective induction of a TH1-associated (CXCL10) and a TH2-associated chemokine (CCL2) in the serum of individuals with KD, suggesting a mixed TH1/TH2 response at the level of chemokine production and subsequent cell recruitment and thus pointing at a potential role for these chemokines in the pathology of KD.
Shikishima
Yasufumi
Y
Department of Pediatrics, Kitasato University School of Medicine, Kitasato, Sagamihara, Kanagawa, Japan.
Saeki
Toshiaki
T
Matsuura
Nobuo
N
D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000097:blood; D054422:Chemokine CCL22; D054357:Chemokine CXCL10; D018925:Chemokines / Q000097:blood*; D019742:Chemokines, CC / Q000097:blood; D019743:Chemokines, CXC / Q000097:blood; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D007564:Japan; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood*; D013223:Statistics as Topic
D015415:Biomarkers; C111835:CCL2 protein, human; C515482:CCL22 protein, human; D018932:Chemokine CCL2; D054422:Chemokine CCL22; D054357:Chemokine CXCL10; D018925:Chemokines; D019742:Chemokines, CC; D019743:Chemokines, CXC