title: Lymphangiosarcoma in a dog treated with surgery and chemotherapy.
abstract: A large subcutaneous mass at the left cervical site in a 9-year-old male Siberian husky was removed surgically. Histopathologically, the mass was mainly consisted of a proliferation of spindle-shaped neoplastic cells arranging in solid sheath and partially vascular channels containing few blood cells. The tumor cells exhibited highly invasive activity to the surrounding tissues. In addition, the tumor cells were immunopositive for Factor VIII-related antigen. On the basis of these findings, the tumor was diagnosed as lymphangiosarcoma. Recurrent mass was noticed 3 weeks after surgery but completely disappeared after the doxorubicin treatment. Neither recurrence nor metastasis was observed for 9 months after the remission.
authors.affiliation: Aoba Animal Hospital, Miyazaki, Japan.
authors.forename: Teruo
authors.initials: T
authors.lastname: Itoh
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mikawa
authors.forename: Mayumi
authors.initials: M
authors.lastname: Mikawa
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nibe
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
mesh_terms: D000818:Animals; D044963:Biopsy, Fine-Needle / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use*; D006652:Histological Techniques; D008204:Lymphangiosarcoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D008297:Male; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
chemical_list: D004317:Doxorubicin