Neuroretinitis in patients with multiple sclerosis.
OBJECTIVE
To present a case series of three patients with neuroretinitis associated with multiple sclerosis.


METHODS
Retrospective, noncomparative, consecutive, interventional case series.


METHODS
Thirty-five consecutive patients with neuroretinitis.


METHODS
The records of 35 consecutive patients with neuroretinitis were reviewed for prior, concurrent, or subsequent development of multiple sclerosis.


METHODS
Presentation, clinical course, and diagnosis of multiple sclerosis.


RESULTS
Three of 35 patients (8.6%) with neuroretinitis were diagnosed with multiple sclerosis by the McDonald criteria. One of the three patients underwent brain biopsy that further confirmed multiple sclerosis. Neuroretinitis in the three patients occurred after the diagnosis of multiple sclerosis. All three patients with multiple sclerosis had been treated with interferon beta before or concurrently with the development of neuroretinitis.


CONCLUSIONS
Neuroretinitis can be an associated manifestation of multiple sclerosis. The possible association between neuroretinitis and interferon beta warrants further investigation.
Williams
Kyle E
KE
Neuro-Ophthalmology Unit, Mason Eye Institute, University of Missouri-Columbia, Columbia, Missouri 65212, USA. JohnsonLN@health.missouri.edu
Johnson
Lenworth N
LN
D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012173:Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies; D014792:Visual Acuity
D005938:Glucocorticoids; D008775:Methylprednisolone