[Geranylgeranylacetone, an antiulcer drug, potently inhibits formation and function of human osteoclasts in vitro and bone loss in ovariectomized rats].
Nanke
Yuki
Y
Institute of Rheumatology, Tokyo Women's Medical University.
Kotake
Shigeru
S
Kamatani
Naoyuki
N
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D015519:Bone Density / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D004967:Estrogens / Q000172:deficiency; D006801:Humans; D010010:Osteoclasts / Q000166:cytology* / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D010052:Ovariectomy; D011106:Polyisoprenyl Phosphates / Q000037:antagonists & inhibitors
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D004967:Estrogens; D011106:Polyisoprenyl Phosphates; C002963:geranylgeranyl pyrophosphate; C031049:geranylgeranylacetone