title: Experimental swine dysentery: comparison between infection models.
abstract: The aim of the present study was to develop a reproducible porcine infection model with Brachyspira hyodysenteriae. The influence of different factors was evaluated, namely, age, a diet containing large quantities of soybean meal, housing and administration of cortisol or antacids. Furthermore, the synergistic effect of additional bacteria (Escherichia coli O141, Bacteroides vulgatus or a mixture of Bacteroides fragilis, a field isolate of Bacteroides and Fusobacterium necrophorum) was studied. Experimental infection resulted in an increase in the serum concentrations of the acute-phase proteins serum amyloid A and haptoglobin and the percentages of neutrophils and monocytes. These alterations were specifically related to haemorrhagic diarrhoea. Inoculation combined with feeding of large quantities of soybean meal and group-housing induced swine dysentery in all experimental animals. If the pigs were fed soybean meal, kept in single pens and circulated between the pens, five out of nine developed disease.
authors.affiliation: Department of Large Animal Clinical Sciences1 and Department of Pathology2, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden 3National Veterinary Institute, Uppsala, Sweden.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Jacobson
authors.affiliation: Department of Large Animal Clinical Sciences1 and Department of Pathology2, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden 3National Veterinary Institute, Uppsala, Sweden.
authors.forename: Claes
authors.initials: C
authors.lastname: Fellström
authors.affiliation: Department of Large Animal Clinical Sciences1 and Department of Pathology2, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden 3National Veterinary Institute, Uppsala, Sweden.
authors.forename: Ronny
authors.initials: R
authors.lastname: Lindberg
authors.affiliation: Department of Large Animal Clinical Sciences1 and Department of Pathology2, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden 3National Veterinary Institute, Uppsala, Sweden.
authors.forename: Per
authors.initials: P
authors.lastname: Wallgren
authors.affiliation: Department of Large Animal Clinical Sciences1 and Department of Pathology2, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden 3National Veterinary Institute, Uppsala, Sweden.
authors.forename: Marianne
authors.initials: M
authors.lastname: Jensen-Waern
mesh_terms: D000367:Age Factors; D000821:Animal Feed / Q000009:adverse effects; D000818:Animals; D000863:Antacids / Q000008:administration & dosage; D017401:Brachyspira hyodysenteriae; D003907:Dexamethasone / Q000008:administration & dosage; D004195:Disease Models, Animal; D004403:Dysentery / Q000209:etiology / Q000382:microbiology / Q000662:veterinary*; D005243:Feces / Q000382:microbiology; D005938:Glucocorticoids / Q000008:administration & dosage; D006242:Haptoglobins / Q000032:analysis; D006799:Housing, Animal; D007420:Intestine, Large / Q000473:pathology; D007958:Leukocyte Count / Q000662:veterinary; D000685:Serum Amyloid A Protein / Q000032:analysis; D013025:Glycine max / Q000009:adverse effects; D013145:Spirochaetales Infections / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000209:etiology* / Q000382:microbiology / Q000473:pathology
chemical_list: D000863:Antacids; D005938:Glucocorticoids; D006242:Haptoglobins; D000685:Serum Amyloid A Protein; D003907:Dexamethasone