[The use of two-route Cisplatin chemotherapy in the treatment of oral squamous cell carcinoma].
OBJECTIVE
To study the feasibility and efficacy of two-route cisplatin chemotherapy for locally advanced squamous cell carcinoma of oral cavity.


METHODS
23 cases with clinical advanced biopsy-proven oral squamous cell carcinoma received intraarterial chemotherapy with cisplatin (DDP), Pingyangmycin (PYM) and 5-fluorouracilum (5-Fu), at the same time intravenous infusion with natrii thiosulfas (STS) for rescue. DDP at 40-60 mg/d, PYM at 16 mg/d and 5-Fu at 500 mg/d were applied for 5-7 consecutive days.


RESULTS
7 cases (33.3%) obtained a complete response (CR), 11(52.4%) had partial response (PR) with an objective response rate (RR) of 85.7%. No severe toxicity was observed, whereas the most frequent grade I and II drug related toxicities were nausea and vomiting. No nephrotoxicity,hepatotoxicity and severe bone marrow suppression were noted.


CONCLUSIONS
Two-route cisplatin chemotherapy is, in our experience,a new,effective and safe therapeutic method for oral squamous cell carcinoma.
Li
W S
WS
Department of Oral Surgery,Children's Hospital of Chongqing Medical University. Chongqing 400014, China.
Wei
S C
SC
Liang
S Z
SZ