[HIV resistance. More the rule than an exception].
Resistance-associated mutations of the HIV genome are one major reason for failure of highly, active antiretroviral therapy. The accumulation of resistance is demonstrated by data from the HCUS-study, where resistant virus strains were isolated in about 50%. More than 60% of the patients showed therapy failure in this survey, and resistance was found in almost 80% of these. Mutations in the HIV genome were also described in treatment-naive patients. In the German Seroconverter Study the rate of resistance was 12%, in a multicenter study in Nordrhein-Westfalen resistant isolates were found in 14% of chronically infected cases. The wide distribution of HIV resistance in treated and untreated patients is an important problem in the management of HIV-infection. It requires a rational application of resistance testing. International studies are under way to further characterize the relevance of the phenomenon of HIV resistance.
Oette
M
M
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Düsseldorf. oettem@med.uni-duesseldorf.de
Kaiser
R
R
Häussinger
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000635:transmission / Q000821:virology; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects; D024921:Drug Resistance, Multiple, Viral / Q000235:genetics; D005060:Europe; D005838:Genotype; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis / Q000187:drug effects / Q000235:genetics; D010641:Phenotype; D017410:Practice Guidelines as Topic
D019380:Anti-HIV Agents