[Dysregulation pathology of hemopoietic and immune systems under infectious process].
Blood system and immune system play the crucial role in maintenance of anti-infectious defence of macroorganism. Meanwhile, infectious agents, differencing by their nature, have marked mutafacient effect on immunocompetent cells of blood. Dysregulation of DNK-reparation systems, apoptosis and immunity, maintaining genetic homeostasis of organism, is considered to be the basic reason of cytogenetic instability under infectious process. It has been established, that disturbances in blood and immunity systems, following infectious process, are caused by not only direct or indirect action of infectious agents on mature immunocytes, but else by their stimulating or suppressed influence on functional properties of early cells-precursors of hemo- and immunopoesis and hemopoietic microenvironment.
Novitskiĭ
V V
VV
Siberian State Medical University of RF MH, Tomsk.
Urazova
O I
OI
D000818:Animals; D017209:Apoptosis; D001424:Bacterial Infections / Q000276:immunology / Q000503:physiopathology*; D001773:Blood Cells / Q000276:immunology; D004247:DNA / Q000235:genetics; D004260:DNA Repair; D006413:Hematopoietic System / Q000503:physiopathology*; D006706:Homeostasis; D007107:Immune System / Q000503:physiopathology*; D016296:Mutagenesis; D013234:Stem Cells / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000503:physiopathology*
D004247:DNA