title: Control of melanoma progression by various matrikines from basement membrane macromolecules.
abstract: Many biological processes such as cell differentiation, cell migration or gene expression are tightly controlled by cell-cell interactions or by various cytokines. During tumor progression, cancer cells are in contact with extracellular matrix (ECM) macromolecules involving specific receptors such as integrins. The different stages of tumor progression, and mainly the proteolytic cascades implicated in extracellular matrix degradation and cell migration, may be controlled by the extracellular matrix macromolecules or by domains released by directed and limited proteolysis of these molecules. In this review, we summarise the biological effects of various peptides, named matrikines, derived from basement membranes (BM) components, such as laminins (LN), proteoglycans or collagens. These peptides may control tumor progression by regulating the proteolytic cascades leading to cancer cell dissemination and metastasis.
authors.affiliation: Laboratoire de Biochimie Médicale et Biologie Moléculaire, CNRS FRE 2534, Faculté de Médecine, IFR 53 Biomolécules, 51 Rue Cognac Jay, 51095 Reims Cedex, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Pasco
authors.forename: Laurent
authors.initials: L
authors.lastname: Ramont
authors.forename: François-Xavier
authors.initials: FX
authors.lastname: Maquart
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Monboisse
mesh_terms: D001485:Basement Membrane / Q000378:metabolism*; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008545:Melanoma / Q000473:pathology*; D009361:Neoplasm Invasiveness; D010455:Peptides / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism
chemical_list: D010455:Peptides; D010960:Plasminogen Activators; D020782:Matrix Metalloproteinases