Self-aggregation of reverse bis peptide conjugate derived from the unstructured region of the prion protein.
A novel bis scaffold containing a pentapeptide PHGGG, derived from the prion octarepeat, forms fibrils of nanometric dimensions, thus indicating that certain segments in the unstructured region of the prion protein may facilitate an initial fibrillation event.
Madhavaiah
C
C
Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur-208016, UP, India.
Verma
Sandeep
S
D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011328:Prions / Q000737:chemistry*
D010455:Peptides; D011328:Prions