Update on antifibrotic use in glaucoma surgery, including use in trabeculectomy and glaucoma drainage implants and combined cataract and glaucoma surgery.
OBJECTIVE
This paper summarizes the use of antifibrotic agents adjunctive to glaucoma surgery, reviews recently published studies that address current use of these antifibrotics, and reviews new methods of wound modulation.


RESULTS
The use of antifibrotic agents, namely, 5-fluorouracil and mitomycin C, in conjunction with glaucoma surgery has resulted in lower postoperative intraocular pressures after trabeculectomy or combined cataract and glaucoma surgery. Mixed results have been seen when these agents are used with glaucoma drainage device surgery. The use of antifibrotic agents has also created and increased complications. Therefore, methods of antifibrotic use have become more refined and modified for specific circumstances. Promising new wound modulation agents, such as CAT-152, are currently under study.


CONCLUSIONS
Antifibrotics are potent adjuncts to glaucoma surgery, but along with their beneficial use are risks that need to be considered. While we continue to look for more efficacious agents and methods to treat glaucoma, we must continue to modify techniques with the individual patient's best interest in mind.
Yoon
Patricia S
PS
Stanford University, School of Medicine, Stanford, California, USA. psyoon@stanford.edu
Singh
Kuldev
K
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D002387:Cataract Extraction; D005355:Fibrosis / Q000517:prevention & control; D005472:Fluorouracil / Q000627:therapeutic use*; D005901:Glaucoma / Q000601:surgery*; D020327:Glaucoma Drainage Implants; D006801:Humans; D016685:Mitomycin / Q000627:therapeutic use*; D014130:Trabeculectomy
D000964:Antimetabolites, Antineoplastic; D016685:Mitomycin; D005472:Fluorouracil