HOMOLOGY-DEPENDENT GENE SILENCING IN PLANTS.
Homology-dependent gene silencing phenomena in plants have received considerable attention, especially when it was discovered that the presence of homologous sequences not only affected the stability of transgene expression, but that the activity of endogenous genes could be altered after insertion of homologous transgenes into the genome. Homology-mediated inactivation most likely comprises at least two different molecular mechanisms that induce gene silencing at the transcriptional or posttranscriptional level, respectively. In this review we discuss different mechanistic models for plant-specific inactivation mechanisms and their relationship with repeat-specific silencing phenomena in other species.
Meyer
P.
P
Max-Delbruck-Laboratorium in der MPG, Carl-von-Linne Weg 10, Koln, D-50829 Germany, Centre for Plant Biochemistry & Biotechnology and Department of Genetics, University of Leeds, Leeds LS2 9JT, United Kingdom, Max-Planck-Institut fur Zuchtungsforschung, Carl-von-Line Weg 10, Koln, D-50829 Germany.
Saedler
H.
H