title: A bolus/infusion paradigm for the novel NMDA receptor SPET tracer [123I]CNS 1261.
abstract: We have previously performed quantitative kinetic modeling of [(123)I]CNS 1261, a new SPET ligand for the MK801 intrachannel site of the NMDA receptor. We now report a bolus-infusion protocol, which eliminates the need for arterial blood sampling. Dynamic SPET scanning and venous blood sampling were performed in 7 healthy volunteers. Good agreement was obtained between kinetic and equilibrium analysis. SPET scanning with a bolus-infusion protocol is a valid method to estimate the total volume of distribution for [(123)I]CNS 1261 in clinical populations.
authors.affiliation: Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK.
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Bressan
authors.forename: Kjell
authors.initials: K
authors.lastname: Erlandsson
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Mulligan
authors.forename: Roger N
authors.initials: RN
authors.lastname: Gunn
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Cunningham
authors.forename: Jonathan
authors.initials: J
authors.lastname: Owens
authors.forename: Ian D
authors.initials: ID
authors.lastname: Cullum
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ell
authors.forename: Lyn S
authors.initials: LS
authors.lastname: Pilowsky
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D003198:Computer Simulation; D005260:Female; D006146:Guanidines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007262:Infusions, Intravenous / Q000379:methods*; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011865:Radioisotope Dilution Technique; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: C417904:CNS 1261; D006146:Guanidines; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D016194:Receptors, N-Methyl-D-Aspartate