[Studies on the constituents from the herb of Vernonia patula].
OBJECTIVE
To isolate and elucidate the chemical constituents of the whole plant of Vernonia patula, and to provide samples for biological activity screening.


METHODS
The chromatography on silica gel was used and the structures were determined by IR, NMR and MS spectra analysis and physicochemical property comparion.


RESULTS
Four triterpenoids were isolated and identified as bauerenyl acetate(I), friedelin(II), epifriedelanol(III), 20(30)-taraxastene-3 beta, 21 alpha-diol(IV).


CONCLUSIONS
Compounds I and IV were isolated from genus Vernonia for the first time and compounds II and III were isolated from the whole plant of V. patula for the first time. The four compounds show no inhibitory effect on the growing of PC-12 cells.
Liang
Qiao-li
QL
Nanjing Normal University, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, China. liangqiaoli@sohu.com
Min
Zhi-da
ZD
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035741:Vernonia / Q000737:chemistry*; D000094042:Lupanes
D004365:Drugs, Chinese Herbal; D009828:Oleanolic Acid; D014315:Triterpenes; C477171:bauerenyl acetate; C055670:friedelinol; C060796:friedelin; D000094042:Lupanes