title: Perinatal choline supplementation does not mitigate motor coordination deficits associated with neonatal alcohol exposure in rats.
abstract: Prenatal alcohol exposure can disrupt brain development, leading to a variety of behavioral alterations including learning deficits, hyperactivity, and motor dysfunction. We have been investigating the possibility that perinatal choline supplementation may effectively reduce the severity of alcohol's adverse effects on behavioral development. We previously reported that perinatal choline supplementation can ameliorate alcohol-induced learning deficits and hyperactivity in rats exposed to alcohol during development. The present study examined whether perinatal choline supplementation could also reduce the severity of motor deficits induced by alcohol exposure during the third trimester equivalent brain growth spurt. Male neonatal rats were assigned to one of three treatment groups. One group was exposed to alcohol (6.6 g/kg/day) from postnatal days (PD) 4 to 9 via an artificial rearing procedure. Artificially and normally reared control groups were included. One half of subjects from each treatment received daily subcutaneous injections of a choline chloride solution from PD 4 to 30, whereas the other half received saline vehicle injections. On PD 35-37, subjects were tested on a parallel bar motor task, which requires both balance and fine motor coordination. Ethanol-exposed subjects exhibited significant motor impairments compared to both control groups whose performance did not differ significantly from one another. Perinatal choline treatment did not affect motor performance in either ethanol or control subjects. These data indicate that the beneficial effects of perinatal choline supplementation in ethanol-treated subjects are task specific and suggest that choline is more effective in mitigating cognitive deficits compared to motor deficits associated with developmental alcohol exposure.
authors.affiliation: Center for Behavioral Teratology, Department of Psychology, San Diego State University, 6363 Alvarado Ct. Ste 209, San Diego, CA 92120, USA. thomas3@mail.sdsu.edu
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Teresa M
authors.initials: TM
authors.lastname: O'Neill
authors.forename: Hector D
authors.initials: HD
authors.lastname: Dominguez
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D002492:Central Nervous System Depressants / Q000633:toxicity*; D002794:Choline / Q000627:therapeutic use*; D019587:Dietary Supplements; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011596:Psychomotor Disorders / Q000139:chemically induced / Q000178:diet therapy*; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D002794:Choline