title: Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation.
abstract: In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines. Employing flow cytometry, it could be determined that mannan inhibits the proliferative response in normal and tumoral cells. Mannan affects the expression of CD3(+) SpMC indicating that mannan inhibits mainly T lymphocyte proliferative response. Also in SpMC cultured with or without mitogen mannan produces an increase of an activation marker (CD25). On C1498 cell line, mannan reduces CD3 expression and abolishes the CD25 expression. In conclusion, mannan has a dual beneficial effect when applied to normal and tumoral cells at the same time by inhibiting the activation of cancer cells and improving that of normal ones.
authors.affiliation: Departamento de Química Biológica-CIQUIBIC, Facultad Ciencias Químicas, Universidad Nacional de Córdoba, Cuidad Universitaria, C5000GYA-Córdoba 5016, Argentina.
authors.forename: M Cecilia
authors.initials: MC
authors.lastname: Sampedro
authors.forename: Rodolfo L
authors.initials: RL
authors.lastname: Artola
authors.forename: Mariano
authors.initials: M
authors.lastname: Murature
authors.forename: Domingo
authors.initials: D
authors.lastname: Murature
authors.forename: Yanina
authors.initials: Y
authors.lastname: Ditamo
authors.forename: German A
authors.initials: GA
authors.lastname: Roth
authors.forename: Silvia
authors.initials: S
authors.lastname: Kivatinitz
mesh_terms: D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006224:Cricetinae; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D008297:Male; D008351:Mannans / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D013154:Spleen / Q000166:cytology / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D008351:Mannans; D010936:Plant Extracts