[Effect of SS8, the active part of Spatholobus suberectus Dunn, on proliferation of hematopoietic progenitor cells in mice with bone marrow depression].
OBJECTIVE
To investigate the effect of SS8, a monomer extracted from Spatholobus suberectus Dunn used for invigorating the circulation of blood, on proliferation of hematopoietic progenitor cells in mice with bone marrow depression.


METHODS
The method of semi-solid culture with methylcellulose of CFU-GM, CFU-E, BFU-E, CFU-Meg was adopted in bone marrow depressed mice which were treated with SS8 for a long time.


RESULTS
The experimental data demonstrated that the numbers of CFU-GM, CFU-E, BFU-E, CFU-Meg in bone marrow depressed mice were raised distinctly under the control of SS8 as compared with those of contrast group. The effect of SS8 became stronger as time went on and the dosage rose.


CONCLUSIONS
SS8 can distinctly stimulate the proliferation of hematopoietec progenitor cells in mice with bone marrow depression in a time-and-dosagedependent manner.
Wang
Dong-xiao
DX
Research Institute for Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.
Chen
Meng-li
ML
Yin
Jian-fen
JF
Liu
Ping
P
D000818:Animals; D001854:Bone Marrow Cells / Q000528:radiation effects*; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000528:radiation effects; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D014916:Whole-Body Irradiation
D004365:Drugs, Chinese Herbal