title: Effects of hydrogen peroxide on contraction of skinned aorta from guinea pigs.
abstract: We examined the effects of hydrogen peroxide (H2O2) on the contractile force of cell membrane permeabilized descending thoracic aorta from guinea pigs. H2O2 enhanced generated force in the Ca2+-induced contraction at any given concentration of Ca2+, and maintained force level in the 30 mM Mg2+-induced Ca2+-independent force maintenance. H2O2 seems to directly enhance the cross-bridge interaction of aortic smooth muscles.
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-0023 Japan. celsior@vc.kcom.ne.jp
authors.forename: Wataru
authors.initials: W
authors.lastname: Sakurai
authors.forename: Masaru
authors.initials: M
authors.lastname: Watanabe
authors.forename: Akira
authors.initials: A
authors.lastname: Yamashina
authors.forename: Masato
authors.initials: M
authors.lastname: Konishi
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D002118:Calcium / Q000493:pharmacokinetics; D002462:Cell Membrane / Q000502:physiology; D006168:Guinea Pigs; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000502:physiology*; D016877:Oxidants / Q000494:pharmacology*; D010539:Permeability
chemical_list: D016877:Oxidants; D006861:Hydrogen Peroxide; D002118:Calcium