Toxic epidermal necrolysis-like reaction secondary to colchicine overdose.
Colchicine is a microtubule-inhibiting drug used to treat gout, familial Mediterranean fever and many other skin diseases. Intoxication with colchicine affects multiple organs, often fatally. Cutaneous sequelae of colchicine toxicity are rare. We describe the clinical and histological features of a toxic epidermal necrolysis-like exanthem in a patient who lethally overdosed on colchicine.
Arroyo
M P
MP
The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 560 First Avenue, New York, NY 10016, USA.
Sanders
S
S
Yee
H
H
Schwartz
D
D
Kamino
H
H
Strober
B E
BE
D017209:Apoptosis / Q000502:physiology; D053148:Caspase 3; D020169:Caspases; D003078:Colchicine / Q000009:adverse effects*; D004817:Epidermis / Q000473:pathology; D017809:Fatal Outcome; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D015603:Keratinocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
D006074:Gout Suppressants; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases; D003078:Colchicine