Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis.
Kotamraju
Srigiridhar
S
Biophysics Department, Medical College of Wisconsin, Milwaukee 53226, USA.
Kalivendi
Shasi V
SV
Konorev
Eugene
E
Chitambar
Christopher R
CR
Joseph
Joy
J
Kalyanaraman
B
B
D000154:Aconitate Hydratase / Q000032:analysis; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D002614:Chelating Agents / Q000494:pharmacology; D045304:Cytochromes c / Q000378:metabolism; D004317:Doxorubicin / Q000378:metabolism / Q000633:toxicity*; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism; D006331:Heart Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007502:Iron Chelating Agents / Q000627:therapeutic use; D035941:Iron Regulatory Protein 1 / Q000378:metabolism; D035925:Iron-Regulatory Proteins / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D032342:Muscle Cells / Q000187:drug effects / Q000378:metabolism; D016877:Oxidants / Q000032:analysis / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D011929:Razoxane / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D011990:Receptors, Transferrin / Q000032:analysis / Q000187:drug effects / Q000378:metabolism; D020218:Response Elements; D015398:Signal Transduction; D013481:Superoxides / Q000032:analysis; D015854:Up-Regulation
D000903:Antibiotics, Antineoplastic; D000975:Antioxidants; D002614:Chelating Agents; D007502:Iron Chelating Agents; D035925:Iron-Regulatory Proteins; D016877:Oxidants; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D011990:Receptors, Transferrin; D013481:Superoxides; D011929:Razoxane; D004317:Doxorubicin; D045304:Cytochromes c; D007501:Iron; D020169:Caspases; D000154:Aconitate Hydratase; D035941:Iron Regulatory Protein 1