title: Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.
abstract: A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.
authors.affiliation: Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan. satoung@banyu.co.jp
authors.forename: Nagaaki
authors.initials: N
authors.lastname: Sato
authors.forename: Takunobu
authors.initials: T
authors.lastname: Shibata
authors.forename: Makoto
authors.initials: M
authors.lastname: Jitsuoka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ohno
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Hirohashi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kanno
authors.forename: Hisashi
authors.initials: H
authors.lastname: Iwaasa
authors.forename: Akio
authors.initials: A
authors.lastname: Kanatani
authors.forename: Takehiro
authors.initials: T
authors.lastname: Fukami
mesh_terms: D000631:Aminopyridines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000631:Aminopyridines; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor