The impact of combinatorial methodologies on medicinal chemistry.
Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.
Sanchez-Martin
Rosario M
RM
Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Mittoo
Stifun
S
Bradley
Mark
M
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D008968:Molecular Conformation; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D004364:Pharmaceutical Preparations