Morphometric ultrastructural analysis of satellite cells in denervated rat soleus muscle.
Morphometric analysis of the ultrastructural changes of satellite cells (SCs) of rat soleus muscle 7, 14, and 36 days post denervation was performed. Denervation caused decrease of surface area cross-section of SCs and their nuclei, volume fractions of nucleus and Golgi complex elements and ribosomes number. In contrast, the increase of surface area/volume ratio of SCs and nucleus, volume fraction and number of endosome/lysosome-like structures, and number of caveolae-like structures was noticed. Ultrastructural changes of SCs in denervated muscles strongly suggest decline of cell activity accompanied by increased processes of degradation of material of endo-, and/or egzogenous origin.
Kujawa
Marek
M
Department of Histology and Embryology, Center of Biostructure Research, 02-004 Warsaw, Poland. mkujawa@ib.amwaw.edu.pl
Baran
Wojciech
W
Jankowska-Steifer
Ewa
E
D000818:Animals; D005260:Female; D007091:Image Processing, Computer-Assisted; D008854:Microscopy, Electron; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000166:cytology* / Q000294:innervation / Q000648:ultrastructure; D051381:Rats; D032496:Satellite Cells, Skeletal Muscle / Q000648:ultrastructure*