title: CD4 T cell activation and disease activity at onset of multiple sclerosis.
abstract: We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients.
authors.affiliation: The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup DK-2600, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Jensen
authors.forename: A R
authors.initials: AR
authors.lastname: Langkilde
authors.forename: C
authors.initials: C
authors.lastname: Fenst
authors.forename: M S
authors.initials: MS
authors.lastname: Nicolaisen
authors.forename: H G
authors.initials: HG
authors.lastname: Roed
authors.forename: M
authors.initials: M
authors.lastname: Christiansen
authors.forename: F
authors.initials: F
authors.lastname: Sellebjerg
mesh_terms: D000328:Adult; D000943:Antigens, Differentiation / Q000097:blood / Q000134:cerebrospinal fluid; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018819:Dipeptidyl Peptidase 4 / Q000097:blood / Q000134:cerebrospinal fluid; D004185:Disability Evaluation; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D008213:Lymphocyte Activation / Q000276:immunology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D004676:Myelin Basic Protein / Q000097:blood / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D015375:Receptors, Interleukin-2 / Q000378:metabolism
chemical_list: D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D015375:Receptors, Interleukin-2; D018819:Dipeptidyl Peptidase 4