Frailty models for quality of life in oncology.
Quality of life (QOL) and survival data are commonly measured in clinical trials in oncology. Frailty models are an excellent tool to exploit the natural dependence between these domains. We propose a novel application of frailty models, providing a detailed example relating to QOL in advanced prostate cancer patients. We discuss model fitting, estimation, and interpretation and describe available software.
Troxel
Andrea B
AB
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, USA. atroxel@cceb.upenn.edu
Esserman
Denise A
DA
D017326:Clinical Trials, Phase III as Topic / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D015233:Models, Statistical; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000628:therapy*; D011788:Quality of Life; D013534:Survival