[Preliminary clinical study on krypton laser photodynamic therapy for PWS].
OBJECTIVE
In order to explore an ideal PWS treatment, which could destroy the capillary of lesion without any damage to skin. Based on principle of improving elective therapeutic efficacy of photodynamic therapy, new Krypton laser PDT was introduced to this preliminary clinical trial.


METHODS
The absorptive spectrum was measured on photosensitizer PsD-007. The therapeutic laser dosage and result and side effect were surveyed. Twenty cases of PWS were randomly selected by means of self-control. 413 nm wavelength laser PDT was carried on those patients. Lesion responses were investigated at different phases after treatment. More attention was paid to the result and side effect. Biopsy was taken from one case.


RESULTS
PsD-007 has the soret peak at 408 nm. There was purplish reaction within a week, which disappeared spontaneously within two months. Lesion blanch with neither weeping soakage nor scar formation. All cases got dramatically blanch of lesions. Histological finding revealed red blood cells leaking through broken vessels, while dermal remained normal.


CONCLUSIONS
413 nm Krypton laser PDT had target elective effect, which had satisfactory result. It suggested good potential plication.
Zhou
G Y
GY
Department Of Oral Maxillofacial Surgery, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Zhang
Z Y
ZY