[Effect and mechanism of bishudiwan(BSDW) against allergy].
OBJECTIVE
To investigate the effect and mechanism of BSDW on the model of allergic rhinitis and the model of guinea pigs by histamine shocking in guinea pigs.


METHODS
Using the model of allergic rhinitis in guinea pigs caused by 10% TDI, we observed the effect of BSDW on physiological and pathological symptoms of allergic rhinitis in guinea pigs, the effect of the levels of serum IgE and serum and nasal histamine. Using the model of guinea pigs by histamine shocking, we observed the effect of BSDW on physiological symptoms in guinea pigs.


RESULTS
BSDW significantly relieved the pathological symptoms of allergic rhinitis in guinea pigs, alleviated the hyperplasia of columnar epithelium, decreased the number of monocyte and eosinocyte compared with the model group. It also reduced the levels of serum IgE, and decreased the release of serum and nasal histamine. BSDW significantly prolonged the occurent time of gasping, eclampsia and death caused by shock, reduced the times of gasping in the model of guinea pigs by histamine shocking.


CONCLUSIONS
BSDW has significant effect against allergy. The mechanism relates to its effects of decreasing the levels of serum IgE and inhibiting the release of serum and nasal histamine.
Zhang
Man
M
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. mandy-zh@163.com
Ren
Ying
Y
Song
Chong-shun
CS
Zhao
Feng-zhi
FZ
Hu
Ding-bang
DB
Guo
Jin
J
Yan
Chang-wen
CW
Dai
Xin
X
Yang
Jin-duo
JD
Shun
Hai-xun
HX
D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D030023:Asarum / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D019686:Lamiaceae / Q000737:chemistry; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology*; D010946:Plants, Medicinal / Q000737:chemistry; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology; D031363:Scutellaria / Q000737:chemistry; D014051:Toluene 2,4-Diisocyanate
D018926:Anti-Allergic Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E; D006632:Histamine