Blood cell apoptosis/necrosis: some clinical and laboratory aspects.
Exposure of phosphatidyl-serine on blood cell membrane surface and microvesiculation as the hallmarks of apoptosis/necrosis were investigated. The effect of leukofiltration on the retention/generation of microvesicules, leukocyte subsets and major biological response modifiers were evaluated in a like study. It is concluded that apoptotic cells potentially contribute to transfusion reactions in donor/recipient-specific ways.
Seghatchiana
Jerard
J
Blood Component Technology Consultancy London, England. jseghatchian@btopenworld.com
de Sousa
Gracinda
G
D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers; D001773:Blood Cells / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D018946:Chemokine CCL5 / Q000097:blood; D004906:Erythrocyte Count; D005434:Flow Cytometry; D006801:Humans; D009336:Necrosis; D010976:Platelet Count
D015415:Biomarkers; D018946:Chemokine CCL5