Quercetin, an over-the-counter supplement, causes neuroblastoma-like elevation of plasma homovanillic acid.
A 22-month-old boy, who regularly consumed the oral dietary supplement, quercetin, was suspected erroneously of having a catecholamine-producing tumor, based on elevated serum and urine levels of the dopamine metabolite, homovanillic acid (HVA). Subsequent studies of healthy adult volunteers showed that significant elevations in plasma HVA are a consequence of quercetin ingestion.
Weldin
Josh
J
Department of Pediatrics, Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98195, USA.
Jack
Rhona
R
Dugaw
Kathryn
K
Kapur
Raj P
RP
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003937:Diagnosis, Differential; D019587:Dietary Supplements / Q000009:adverse effects*; D006719:Homovanillic Acid / Q000097:blood* / Q000652:urine; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000097:blood / Q000473:pathology; D010865:Pilot Projects; D011794:Quercetin / Q000009:adverse effects*; D014642:Vanilmandelic Acid / Q000097:blood
D015102:3,4-Dihydroxyphenylacetic Acid; D014642:Vanilmandelic Acid; D011794:Quercetin; D006719:Homovanillic Acid