Impact of cyclosporine in the development of immunosuppressive therapy.
Cyclosporine has been of great interest to the transplant community during the last 20 years. It has permitted an evolution of knowledge through the changes in its original galenic formulation of Sandimmune to Neoral, and now through the recent application of the knowledge of pharmacodynamics and pharmacokinetics to tailor drug doses to each individual. The achievements of cyclosporine are still valid and possibly will be for the next years.
Chaverri
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Nephrology Service at The Mexico Hospital, Social Security, San Jose, Costa Rica. nefrona@racsa.co.cr
D016572:Cyclosporine / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality; D016019:Survival Analysis; D013997:Time Factors; D014181:Transplantation Immunology
D016572:Cyclosporine