[Antistaphylococcal activity of the complex of natural cytokines].
The in vitro study of the action of the complex of natural cytokines (CNC), or preparation Superlymph, on different microbial test strains (Staphylococcus aureus, Escherichia coli, yeast-like fungi of the genus Candida) was carried out. CNC suppressed the growth of S. aureus test culture, depending on the concentration of the preparation. The inhibiting effect was observed in the presence of Ca and Mg bivalent cations in the medium. Under the chosen conditions of the experiment CNC did not inhibit the growth of E. coli test cultures, as well as test cultures of yeast-like fungi of the genus Candida. In addition to its antibacterial effect, Superlymph also produced some effect on the release of cathepsin G, the lysosomal enzyme of human leukocyte granules.
Koval'chuk
L V
LV
Russian State Medical University, Gamaleya Research Institute of Epidemiology and Microbilogy, Moscow, Russia.
Gankovskaia
L V
LV
Moroz
A F
AF
Avedova
T A
TA
Ukhina
T V
TV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002118:Calcium; D002412:Cations; D003470:Culture Media; D016207:Cytokines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008274:Magnesium; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D002412:Cations; D003470:Culture Media; D016207:Cytokines; D008274:Magnesium; D002118:Calcium