C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study.
OBJECTIVE
To determine the impact of moderate alcohol consumption on long term prognosis after successful coronary stenting, and whether it could be related to preprocedural plasma C reactive protein (CRP).


METHODS
Part of the prospectively designed GENERATION study which investigated the impact of several biochemical factors, including plasma CRP, on long term prognosis after coronary stenting.


METHODS
Tertiary referral centre.


METHODS
483 consecutive patients with stable or unstable coronary artery disease who underwent successful coronary stenting and were followed for up to four years. Information about alcohol consumption was collected prospectively.


METHODS
Successful coronary stenting.


METHODS
The incidence of the composite end point of readmission to hospital for unstable angina, non-fatal myocardial infarction, or cardiac death, whichever occurred first.


RESULTS
By the end of follow up the incidence of the composite end point was 22.8%. Patients with a baseline plasma CRP concentration of < 0.68 mg/dl (defined by ROC analysis) did not show any difference in the composite end point (p = 0.9) or its components, regardless of the amount of alcohol consumed during follow up. However, among patients with plasma CRP concentration of > or = 0.68 mg/dl, those who drank moderately had a lower incidence of the composite end point (p < 0.001) or its components.


CONCLUSIONS
Moderate alcohol consumption may have a beneficial impact on the long term prognosis following successful coronary stenting. The extent of this effect is positively related to preprocedural inflammatory status. An anti-inflammatory action of moderate alcohol consumption cannot be excluded.
Zairis
M N
MN
Department of Cardiology, Tzanio Hospital, Piraeus, Greece. zairis@hellasnet.gr
Ambrose
J A
JA
Lyras
A G
AG
Thoma
M A
MA
Psarogianni
P K
PK
Psaltiras
P G
PG
Kardoulas
A D
AD
Bibis
G P
GP
Pissimissis
E G
EG
Batika
P C
PC
DeVoe
M C
MC
Prekates
A A
AA
Foussas
S G
SG
D000428:Alcohol Drinking / Q000097:blood / Q000401:mortality*; D000789:Angina, Unstable / Q000097:blood / Q000401:mortality / Q000601:surgery; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D015607:Stents; D016019:Survival Analysis
D002097:C-Reactive Protein