title: [Effect and mechanism of bishudiwan(BSDW) against allergy].
abstract: OBJECTIVE
  To investigate the effect and mechanism of BSDW on the model of allergic rhinitis and the model of guinea pigs by histamine shocking in guinea pigs.
  
  
  METHODS
  Using the model of allergic rhinitis in guinea pigs caused by 10% TDI, we observed the effect of BSDW on physiological and pathological symptoms of allergic rhinitis in guinea pigs, the effect of the levels of serum IgE and serum and nasal histamine. Using the model of guinea pigs by histamine shocking, we observed the effect of BSDW on physiological symptoms in guinea pigs.
  
  
  RESULTS
  BSDW significantly relieved the pathological symptoms of allergic rhinitis in guinea pigs, alleviated the hyperplasia of columnar epithelium, decreased the number of monocyte and eosinocyte compared with the model group. It also reduced the levels of serum IgE, and decreased the release of serum and nasal histamine. BSDW significantly prolonged the occurent time of gasping, eclampsia and death caused by shock, reduced the times of gasping in the model of guinea pigs by histamine shocking.
  
  
  CONCLUSIONS
  BSDW has significant effect against allergy. The mechanism relates to its effects of decreasing the levels of serum IgE and inhibiting the release of serum and nasal histamine.
authors.affiliation: Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. mandy-zh@163.com
authors.forename: Man
authors.initials: M
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ren
authors.forename: Chong-shun
authors.initials: CS
authors.lastname: Song
authors.forename: Feng-zhi
authors.initials: FZ
authors.lastname: Zhao
authors.forename: Ding-bang
authors.initials: DB
authors.lastname: Hu
authors.forename: Jin
authors.initials: J
authors.lastname: Guo
authors.forename: Chang-wen
authors.initials: CW
authors.lastname: Yan
authors.forename: Xin
authors.initials: X
authors.lastname: Dai
authors.forename: Jin-duo
authors.initials: JD
authors.lastname: Yang
authors.forename: Hai-xun
authors.initials: HX
authors.lastname: Shun
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D030023:Asarum / Q000737:chemistry; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D019686:Lamiaceae / Q000737:chemistry; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology*; D010946:Plants, Medicinal / Q000737:chemistry; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology; D031363:Scutellaria / Q000737:chemistry; D014051:Toluene 2,4-Diisocyanate
chemical_list: D018926:Anti-Allergic Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014051:Toluene 2,4-Diisocyanate; D007073:Immunoglobulin E; D006632:Histamine