Coenzyme Q supplementation protects from age-related DNA double-strand breaks and increases lifespan in rats fed on a PUFA-rich diet.
This study investigates the usefulness of a long-term supplementation with coenzyme Q(10) in rats from the point of view of lifespan, DNA double-strand breaks and to assess whether this supplementation might attenuate oxidative alterations related to PUFA-rich diets, which would allow to preserve beneficial aspects of PUFA on health avoiding their deleterious aspects. Supplemented animals showed higher concentration of coenzyme Q(10) in liver mitochondria, lower levels of DNA double-strand breaks in peripheral blood lymphocytes. Animals supplemented on coenzyme Q reached a significantly higher mean life span (11,7% higher, i.e. 2,5 months) and a significantly higher maximum life span (24% higher, i.e. 6 months) than non-supplemented animals. These results suggest that a long-term supplementation with a small dosage of coenzyme Q(10) might represent a good anti-aging therapy in rats fed on a PUFA-based diet.
Quiles
José L
JL
Department of Physiology, Institute of Nutrition and Food Technology, University of Granada, Ramón y Cajal 4. (Edif. Fray Luis de Granada), Granada 18071, Spain. jlquiles@ugr.es
Ochoa
Julio J
JJ
Huertas
Jesús R
JR
Mataix
José
J
D000375:Aging / Q000235:genetics*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D019587:Dietary Supplements; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D016019:Survival Analysis; D014451:Ubiquinone / Q000494:pharmacology*
D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D014451:Ubiquinone