title: Plasma malondialdehyde, superoxide dismutase, sE-selectin, fibronectin, endothelin-1 and nitric oxide levels in women with preeclampsia.
abstract: OBJECTIVE
  The purpose of this study was to determine plasma malondialdehyde (MDA), superoxide dismutase (SOD), soluble E-selectin (sE-selectin), fibronectin, endothelin-1 (ET-1) and nitric oxide (NO) levels in women with preeclampsia and to find out the relations of diastolic blood pressure with these variables.
  
  
  METHODS
  We performed a case-control study consisting of randomly selected 34 healthy pregnant women and 35 patients diagnosed as preeclampsia. Lipoperoxidation was ascertained by the formation of MDA. SOD activity was determined by the method of Sun et al. Plasma concentration of NO was estimated using colorimetric assay. Plasma ET-1 and sE-selectin were measured by enzyme-linked immunosorbent assay (ELISA). A nephelometric method for fibronectin quantitation was used.
  
  
  RESULTS
  The mean plasma level of MDA was significantly higher and SOD was significantly lower in preeclamptic pregnancies (P<0.001). Plasma concentrations of fibronectin, sE-selectin and ET-1 were significantly increased, whereas NO was significantly decreased in women with preeclampsia than normotensive women (P<0.001).
  
  
  CONCLUSIONS
  Increased plasma levels of MDA, fibronectin, sE-selectin, ET-1, and decreased plasma levels of NO and SOD in preeclamptic patients suggest that poorly perfused fetoplacental unit is the origin of oxygen free radicals and lipid peroxides.
authors.affiliation: Department of Biochemistry, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.
authors.forename: Seval
authors.initials: S
authors.lastname: Aydin
authors.forename: Ali
authors.initials: A
authors.lastname: Benian
authors.forename: Riza
authors.initials: R
authors.lastname: Madazli
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Uludag
authors.forename: Hafize
authors.initials: H
authors.lastname: Uzun
authors.forename: Safiye
authors.initials: S
authors.lastname: Kaya
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D005353:Fibronectins / Q000097:blood; D005609:Free Radicals / Q000097:blood*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D019332:Endothelin-1; D005353:Fibronectins; D005609:Free Radicals; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase