Antioxidative and EROD activities of osajin and pomiferin.
The major constituents of fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Since significant biological activities of extracts from the wood of M. pomifera were previously reported, the peroxynitrite scavenging activity, inhibition of lipid peroxidation, scavenging of DPPH and EROD activity of these two major substances were studied.
Veselá
Dagmar
D
Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackého 1-3, 612 42 Brno, Czech Republic.
Kubínová
Renáta
R
Muselík
Jan
J
Zemlicka
Milan
M
Suchý
Václav
V
D001578:Benzopyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D019363:Cytochrome P-450 CYP1A1 / Q000737:chemistry; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D031624:Maclura; D030421:Peroxynitrous Acid / Q000737:chemistry; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D001578:Benzopyrans; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007529:Isoflavones; D010851:Picrates; D010936:Plant Extracts; D030421:Peroxynitrous Acid; C474837:pomiferin; C485800:osajin; C004931:1,1-diphenyl-2-picrylhydrazyl; D019363:Cytochrome P-450 CYP1A1