title: [Levosimendan-long-term inodilation in an infant with myocardial infarction].
abstract: An infant with myocardial infarction due to congenital stenosis of the left coronary artery with consecutive left ventricular dysfunction and mitral regurgitation developed refractory pulmonary hypertension (PHT) and recurrent PHT crises. Catecholamines to support cardiac function, or pulmonary vasodilators like inhaled nitric oxide showed no effect. Treatment with Levosimendan (Simdax), a new inodilator, combining both inotropic and pulmonary vasodilating effects, improved left ventricular dysfunction, increased cardiac index, decreased pulmonary vascular resistance and reduced frequency and extent of the PHT crises. This case may suggest the use of Levosimendan as a long-term inotropic agent and pulmonary vasodilator in children with depressed cardiac function.
authors.affiliation: Abteilung für Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
authors.forename: Y C
authors.initials: YC
authors.lastname: Luther
authors.forename: I
authors.initials: I
authors.lastname: Schulze-Neick
authors.forename: B
authors.initials: B
authors.lastname: Stiller
authors.forename: P
authors.initials: P
authors.lastname: Ewert
authors.forename: M
authors.initials: M
authors.lastname: Redlin
authors.forename: B
authors.initials: B
authors.lastname: Nasseri
authors.forename: E G
authors.initials: EG
authors.lastname: Mühler
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
authors.forename: P E
authors.initials: PE
authors.lastname: Lange
mesh_terms: D002303:Cardiac Output, Low / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D023921:Coronary Stenosis / Q000151:congenital* / Q000601:surgery; D003330:Coronary Vessel Anomalies / Q000601:surgery*; D015150:Echocardiography, Doppler / Q000187:drug effects; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000008:administration & dosage*; D006976:Hypertension, Pulmonary / Q000151:congenital* / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D008134:Long-Term Care; D008297:Male; D009203:Myocardial Infarction / Q000151:congenital* / Q000601:surgery; D011183:Postoperative Complications / Q000188:drug therapy*; D011651:Pulmonary Artery / Q000187:drug effects; D011669:Pulmonary Wedge Pressure; D011724:Pyridazines / Q000008:administration & dosage*; D000077464:Simendan; D013318:Stroke Volume / Q000187:drug effects; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D014665:Vasodilator Agents; D000077464:Simendan