Cardiovascular effects of methamphetamine in Parkinson's disease patients.
Cardiovascular responses after intravenous methamphetamine were assessed in 11 Parkinson's disease (PD) patients. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and electrocardiogram (ECG) were monitored for 103 minutes. After methamphetamine administration, SBP and DBP increased significantly in both PD and normal controls whereas placebo had no effect. In PD patients, however, the duration of SBP and DBP responses to methamphetamine and the maximum increase from baseline was attenuated compared with the controls. A significant correlation was found between individual BP responsiveness and the Unified Parkinson's Disease Rating Scale (UPDRS) motor score. These findings suggest that in PD there is impairment of catecholamine release from peripheral sympathetic presynaptic terminals, which correlates with motor impairment.
Pavese
Nicola
N
MRC Clinical Science Center and Division of Neurosciences, Faculty of Medicine, Imperial College. Hammersmith Hospital Campus, London, United Kingdom.
Rimoldi
Ornella
O
Gerhard
Alexander
A
Brooks
David J
DJ
Piccini
Paola
P
D000320:Adrenergic Fibers / Q000187:drug effects; D000704:Analysis of Variance; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D002395:Catecholamines / Q000037:antagonists & inhibitors; D015259:Dopamine Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy*; D017729:Presynaptic Terminals / Q000187:drug effects; D011595:Psychomotor Agitation / Q000209:etiology; D014055:Tomography, Emission-Computed
D002395:Catecholamines; D015259:Dopamine Agents; D008694:Methamphetamine; D007980:Levodopa