The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.
In order to reveal the mechanisms underlying genistein combined polysaccharide (GCP) inhibition of tumor proliferation, we investigated the effects of GCP on the growth of human breast cancer cells transplanted to athymic nude mice. We further investigated the metabolism of genistein and its association with the beta-glucuronidase activity in tumor and normal tissues.
Yuan
Lan
L
Laboratory of Biochemistry, Amino Up Chemical Company, Limited, Sapporo 004-0839, Japan. yuanlan@hotmail.com
Wagatsuma
Chihiro
C
Sun
Buxiang
B
Kim
Jung-Hwan
JH
Surh
Young-Joon
YJ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D005434:Flow Cytometry; D019833:Genistein / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D014183:Transplantation, Heterologous
D011134:Polysaccharides; C473311:genistein combined polysaccharide; D019833:Genistein; D005966:Glucuronidase