title: Clinical and pathological prognostic indicators with colorectal mucinous carcinomas.
abstract: OBJECTIVE
  Colorectal mucinous carcinomas are considered to have a worse prognosis than typical adenocarcinomas. To evaluate the prognostic relevance of a series of clinical and pathological variables, patients with colorectal mucinous carcinomas were studied retrospectively.
  
  
  METHODS
  Ninety-eight patients who underwent surgery for colorectal mucinous carcinomas were included in this study. We firstly examined whether signet-ring cell carcinomas exhibited worse prognosis than the other mucinous carcinomas. Prognostic factors were then analyzed by both univariate and multivariate analysis for 70 patients who underwent complete resection.
  
  
  RESULTS
  The overall five-year survival rate was 44%. Amount of signet-ring cells was a non-significant indicator of poor prognosis. For the cases whose cancers were completely resected, four parameters (liver metastasis, lymph node involvement, vessel involvement, spread beyond the bowel wall) were significantly related to prognosis on univariate analysis. With the multivariate analysis, liver metastasis and spread beyond the bowel wall were independent variables.
  
  
  CONCLUSIONS
  This study reaffirmed the importance of liver metastasis and spread beyond the bowel wall for prediction of prognosis with colorectal mucinous carcinomas for cases who undergo complete resection. In addition, the presence of signet-ring cells is a non-significant indicator of a poor prognosis.
authors.affiliation: Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kubota
authors.forename: Takayuki
authors.initials: T
authors.lastname: Akasu
authors.forename: Shin
authors.initials: S
authors.lastname: Fujita
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Sugihara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Moriya
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000401:mortality / Q000473:pathology; D003110:Colonic Neoplasms / Q000401:mortality* / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality* / Q000473:pathology*