title: Structure of human translin at 2.2 A resolution.
abstract: The structure of human translin at 2.2 A resolution is reported in space group C222(1). Translin forms a tetramer in the asymmetric unit. Although the monomer structure is almost the same as the crystal structure of murine translin in space group P2(1)2(1)2, the relative positions of the tetramers differ between the human and murine translins. This suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA.
authors.affiliation: ZoeGene, 1000 Kamoshida, Aobaku, Yokohama 227-8502, Japan.
authors.forename: Ikuko
authors.initials: I
authors.lastname: Sugiura
authors.forename: Chiduko
authors.initials: C
authors.lastname: Sasaki
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kohno
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Sugio
authors.forename: Hideaki
authors.initials: H
authors.lastname: Moriyama
authors.forename: Masataka
authors.initials: M
authors.lastname: Kasai
authors.forename: Takao
authors.initials: T
authors.lastname: Matsuzaki
mesh_terms: D003460:Crystallization; D018360:Crystallography, X-Ray; D004268:DNA-Binding Proteins / Q000737:chemistry*; D019281:Dimerization; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011487:Protein Conformation
chemical_list: D004268:DNA-Binding Proteins; C095563:TSN protein, human