Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats.
Pharmacokinetics of cefotaxime (50 mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0.75 mg/kg) was administered intravenously, once daily for five consecutive days to induce kidney damage. The pharmacokinetic variables were calculated in both cases. Kidney damage caused several changes in the determined variables. The C(max) and C(min) of cefotaxime observed at 0.50 and 5 h in normal goats were 24.91+/-1.51 and 1.22+/-0.07 micro g/ml, respectively, while the same in kidney damaged goats at 1 and 72 h were 75.00+/-0.45 and 3.10+/-0.09 micro g/ml, respectively. Renal damage condition significantly increased t1/2,ka (0.48+/-0.01 h), t1/2,ke (20.03+/-0.16 h), AUC (2440.10+/-24.26 micro g. h/ml) and significantly decreased Vdarea (0.59+/-0.007 L/kg), Vss (0.58+/-0.007 L/kg) and ClB (0.02+/-0.008 L/kg/h) values of cefotaxime compared to normal goats.
Dutta
Biswa Priya
BP
Department of Pharmacology and Toxicology, Faculty of Veterinary & Animal Sciences, West Bengal University of Animal and Fishery Sciences, Mohanpur, Nadia, 741252, West Bengal, India. drtkm@rediffmail.com
Debnath
Shiben Chandra
SC
Mandal
Tapan Kumar
TK
Chakraborty
Animesh Kumar
AK
D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002439:Cefotaxime / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D015511:Goat Diseases / Q000139:chemically induced / Q000378:metabolism*; D006041:Goats; D006207:Half-Life; D007273:Injections, Intramuscular; D051437:Renal Insufficiency / Q000139:chemically induced / Q000378:metabolism*; D014502:Uranyl Nitrate
D000900:Anti-Bacterial Agents; D014502:Uranyl Nitrate; D002439:Cefotaxime