Seroepidemiology of dengue in the adult population of Singapore.
Urbanization is one of the reasons for the resurgence of dengue in tropical and subtropical countries. We conducted a cross-sectional seroepidemiological study in Singapore to determine the extent at which the Singapore population has been exposed to dengue infections. Dengue antibodies were measures with PanBio Dengue. Of 298 enrolled subjects (age 18-45), 133 (45%) had a positive dengue serology. In multivariate analysis, age and nationality (Singaporean vs non-Singaporean Asians) were found to be significant independent predictors. The odds ratio of dengue seroprevalence increased by 4.13 (95% CI: 2.88-5.93) for every 10 year increase in age. Dengue infections remain a major problem in Singapore.
Wilder-Smith
Annelies
A
Department of Infectious Diseases, Tan Tock Seng Hospital, Jalan Tan Tock Seng, Singapore. epvws@pacific.net.sg
Foo
Winnie
W
Earnest
Arul
A
Sremulanathan
Sangeetha
S
Paton
Nicholas I
NI
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000032:analysis; D003430:Cross-Sectional Studies; D003715:Dengue / Q000453:epidemiology* / Q000208:ethnology / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012846:Singapore / Q000453:epidemiology
D000914:Antibodies, Viral