title: Increased cell-free DNA in plasma of patients with metastatic spread in prostate cancer.
abstract: We compared the plasma DNA concentrations in patients with different prostate cancer (PCa) stages and with benign prostate hyperplasia (BPH) and in healthy persons. Patients with localized cancer had DNA plasma within the reference interval. Increased plasma DNA was found in patients with lymph node and distant metastases and also in BPH. The association between plasma DNA and the survival time was similarly strong as with prostate-specific antigen. It can be concluded that plasma DNA has a limited validity as metastatic marker in PCa patients but follow-up studies combined with the investigation of tumor-related characteristics of plasma DNA would be reasonable.
authors.affiliation: Department of Urology, University Hospital Charité, Humboldt University, Schumannstrasse 20/21, D-10098 Berlin, Germany. klaus.jung@charite.de
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
authors.forename: Carsten
authors.initials: C
authors.lastname: Stephan
authors.forename: Michaela
authors.initials: M
authors.lastname: Lewandowski
authors.forename: Silke
authors.initials: S
authors.lastname: Klotzek
authors.forename: Monika
authors.initials: M
authors.lastname: Jung
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
authors.forename: Michael
authors.initials: M
authors.lastname: Lein
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Loening
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schnorr
mesh_terms: D004247:DNA / Q000097:blood*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology
chemical_list: D004247:DNA; D017430:Prostate-Specific Antigen