title: Pharmacokinetic interaction of ibuprofen enantiomers in rabbits.
abstract: The potential interaction between two ibuprofen enantiomers was studied after intravenous administration of R-(-)-, S-(+)- and racemic ibuprofen to rabbits. The total body clearance values calculated by compartmental model analysis (0.65 +/- 0.21 for R-(-)-ibuprofen and 0.63 +/- 0.34 for S-(+)-ibuprofen) after intravenous administration of the racemate of ibuprofen were significantly smaller than those of individual enantiomers (0.95 +/- 0.23 for R-(-)-ibuprofen and 1.03 +/- 0.23 for S-(+)-ibuprofen), indicating that the enantiomer-enantiomer interaction results in a mutual inhibition. The enantiomeric interaction in the pharmacokinetic behaviour of ibuprofen after racemic administration is considered to be a result of an alteration in the metabolic or excretion phase (or both) rather than stereoselective protein binding in the systemic distribution.
authors.affiliation: Department of Pharmacology and Therapeutics, Hokkaido College of Pharmacy, Katsuraoka, Otaru 047-0264, Japan.
authors.forename: Wenhui
authors.initials: W
authors.lastname: Lin
authors.forename: Toru
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Hitomi
authors.initials: H
authors.lastname: Yanaguimoto
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kuzuba
authors.forename: Takako
authors.initials: T
authors.lastname: Obara
authors.forename: Guohua
authors.initials: G
authors.lastname: Ding
authors.forename: Fude
authors.initials: F
authors.lastname: Cui
authors.forename: Nobuo
authors.initials: N
authors.lastname: Inotsume
mesh_terms: D000818:Animals; D019540:Area Under Curve; D007052:Ibuprofen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D011817:Rabbits; D013237:Stereoisomerism
chemical_list: D007052:Ibuprofen