Involvement of N-methyl-d-aspartate (NMDA) receptors in a rat model of visceral hypersensitivity.
N-Methyl-d-aspartate (NMDA) is known to be involved in the transmission of nociceptive information. In the present study, we investigated the effect of peripheral and central NMDA receptor antagonist MK-801 in visceral hypersensitivity. In an animal model of colorectal distension (CRD), administration of both intrathecal MK-801 (1.5 nmol) and intraperitoneal MK-801 (0.15 mg/kg) completely abolished the CRD-induced visceral hypersensitivity of noxious and innocuous stimuli. Thus, the results from this experiment demonstrate the efficacy of MK-801 in blocking the visceral hypersensitivity mediated by central and peripheral mechanisms.
Gaudreau
Geneviève-Anne
GA
Neurobiology and Digestive Motility Laboratory, Hopital St-Luc, CHUM Research Center, University of Montreal, 264 East René-Lévesque, Montréal, Que., Canada H2X 1P1.
Plourde
Victor
V
D000005:Abdomen / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003106:Colon / Q000502:physiology; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006930:Hyperalgesia / Q000503:physiopathology*; D007274:Injections, Intraperitoneal; D007278:Injections, Spinal; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D012007:Rectum / Q000502:physiology
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate