Fragmentation pathway of dopamine transporter ligands: N-substituted-2beta-carbomethoxy-3beta-phenylnortropane derivatives.
Electron impact mass spectra of iodinated tropane derivatives which are of clinical importance are described. The major fragment ions were found to come from the cleavage of the Calpha-Cbeta bond of the bridgehead nitrogen, affording to hydrogenopyrrolidine derivatives ions. The fragment ions generated from the EI mass spectra were assigned and fragmentation mechanisms were proposed.
Mavel
Sylvie
S
Laboratoire de Biophysique Médicale, Faculté de Pharmacie, INSERM U316, 31 av. Monge, 37200 Tours, France. mavel@univ-tours.fr
Abarbri
Mohamed
M
Frangin
Yves
Y
Duchène
Alain
A
Emond
Patrick
P
D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D004298:Dopamine / Q000737:chemistry*; D050483:Dopamine Plasma Membrane Transport Proteins; D008401:Gas Chromatography-Mass Spectrometry; D008024:Ligands; D008562:Membrane Glycoproteins / Q000737:chemistry*; D026901:Membrane Transport Proteins / Q000737:chemistry*; D015394:Molecular Structure; D009419:Nerve Tissue Proteins / Q000737:chemistry*
D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D003042:Cocaine; D004298:Dopamine