title: Cytotoxic effects of B lymphocytes mediated by reactive oxygen species.
abstract: Reactive oxygen species (ROS) are produced in all mammalian cells as a result of norman cellular metabolism and due to the activation of oxidant-producing enzymes in response to exogenous stimuli. The balance between ROS production and antioxidant defenses determines the degree of oxidative stress. Generation of ROS has been associated with cell signaling, stress responses, cell proliferation, aging and cancer development. The ability of ROS to induce cellular damage and to cause cell death opens the possibility to exploit this property in the treatment of cancer through a fee radical-mediated mechanism.
authors.affiliation: Hematopathology Unit and Department of Hematology, Institut Clinic de Malaties Hematològiques i Oncològiques (ICMHO), Hospital Clinic, Institut d'Investigacions Biomèdiques Ausgust Pi iSunyer (IDIBAPS), Barcelona, Spain.
authors.forename: Neus
authors.initials: N
authors.lastname: Villamor
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
authors.forename: Dolors
authors.initials: D
authors.lastname: Colomer
mesh_terms: D000077584:2-Methoxyestradiol; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20 / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000494:pharmacology / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism*; D001569:Benzodiazepines / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006588:Hexanones / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D010087:Oxides / Q000494:pharmacology / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism*; D000069283:Rituximab; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D000970:Antineoplastic Agents; D001152:Arsenicals; D006588:Hexanones; D010087:Oxides; D017382:Reactive Oxygen Species; D001569:Benzodiazepines; D000069283:Rituximab; D004958:Estradiol; C014919:4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one; D000077584:2-Methoxyestradiol; C468549:Bz-423; D000077237:Arsenic Trioxide