title: Effect of trimethoprim-sulfamethoxazole prophylaxis in AIDS patients on the formation of the small colony variant phenotype of Staphylococcus aureus.
abstract: Emergence of Staphylococcus aureus small colony variants (SCVs) has been associated with antibiotic use, particularly with trimethoprim-sulfamethoxazole (TMP-SMZ). In this study, 634 specimens of 125 patients with AIDS were prospectively screened for S. aureus with normal phenotype and for S. aureus SCVs. Charts of these patients were reviewed for previous prophylaxis with TMP-SMZ often used as long-term pneumocystosis prophylaxis. Thirty-seven patients (29.6%) harbored S. aureus in their anterior nares, three of these patients (8.1%) had S. aureus SCVs. Interestingly, TMP-SMZ does not appear to select for S. aureus SCVs in nasal swabs of these patients.
authors.affiliation: Institute of Medical Microbiology, University of Münster, Hospital and Clinics, Münster, Germany. eiffc@uni-muenster.de
authors.forename: Christof
authors.initials: C
authors.lastname: von Eiff
authors.forename: Gabriele
authors.initials: G
authors.lastname: Lubritz
authors.forename: Christoph
authors.initials: C
authors.lastname: Heese
authors.forename: Georg
authors.initials: G
authors.lastname: Peters
authors.forename: Karsten
authors.initials: K
authors.lastname: Becker
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology / Q000517:prevention & control; D019072:Antibiotic Prophylaxis; D015169:Colony Count, Microbial; D003470:Culture Media; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D012680:Sensitivity and Specificity; D013203:Staphylococcal Infections / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D003470:Culture Media; D015662:Trimethoprim, Sulfamethoxazole Drug Combination