Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues.
Monoamine oxidase (MAO) A and B and semicarbazide-sensitive amine oxidase (SSAO) localizations in peripheral human tissues were compared by immunohistochemistry. The primary antibodies used were mouse monoclonal anti-human MAO-A (6G11/E1) and anti-human MAO-B (3F12/G10/2E3) and a rabbit polyclonal anti-bovine SSAO antibody. Immunoreactivities of the samples, obtained from 6 routine autopsy cases, showed different distributions in the tissues studied (heart, lung, duodenum, liver, pancreas, spleen, thyroid gland, adrenal gland and kidney). The relative MAO-A, MAO-B and SSAO distributions indicated a widespread distribution of these enzymes in the human body that is characterized by a matching cellular pattern in only few tissues. These differences suggest that each amine oxidase may play a specific function in, at least some, peripheral tissues.
Ramonet
D
D
Unitat de Bioquímica, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, C/Casanova 143, E-08036 Barcelona, Spain.
Rodríguez
M
M
Saura
J
J
Lizcano
J M
JM
Romera
M
M
Unzeta
M
M
Finch
C
C
Billett
E
E
Mahy
N
N