[Studies on crosslinkable coatings for biomedical application].
A novel crosslinkable coating for biomedical device was prepared by copolymerization of the constituent monomers via a free radical method. 1H-NMR and IR results indicated it had desirable structure. Surface characterization revealed that surface reorganization occurred in aqueous environment and a polyethylene oxied (PEO) enrichment surface was developed on coated surface. The in-vitro platelet-adhesion test and the plasma recalcification time(PRT) determination showed that the coated surface could resist the blood coagulation effectively.
Ji
Jian
J
Department of Polymer Science and Composite Materials, Zhejiang University, Hangzhou 310027, China. jianji@mail.hz.zj.cn
Chen
Weidong
W
Xu
Jianping
J
Shen
Jiacong
J
Fang
Dezeng
D
Sun
Fuyu
F
D001777:Blood Coagulation; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D008422:Materials Testing; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry*; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D003432:Cross-Linking Reagents; D011092:Polyethylene Glycols