title: [Study on a new antarthritic injection--O-carboxymethyl chitosan].
abstract: A type of water-soluble carboxymethyl chitosan (O--CMC), with 76% degree of substitution determined by conductivity method, was prepared by using chloroacetic acid to react with C6-OH of chitosan. The solubility of O--CMC was characterized also. Animal experiment in rabbits showed that O--CMC could lubricate arthron, inhibit proliferation of fibroblast cells on rabbits' knee joints, benefit the process of repairing pathologic articular cartilage, and produce good therapeutic effect on rheumatoid arthritis.
authors.affiliation: Institute of Polymer Composites, Zhejiang University, Hangzhou 310027, China.
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Hu
authors.forename: Zhongming
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.forename: Gende
authors.initials: G
authors.lastname: Gao
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D002358:Cartilage, Articular / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000187:drug effects; D008297:Male; D011817:Rabbits
chemical_list: C514968:carboxymethyl-chitosan; D048271:Chitosan