title: Intravenous methotrexate for treatment of interstitial pregnancy: a case report.
abstract: BACKGROUND
  Ectopic pregnancy is the leading cause of first-trimester maternal death, accounting for 9% of pregnancy-related deaths. Interstitial (cornual) pregnancies represent 6% of all ectopics but account for a disproportionately higher mortality rate. Surgical management has been the treatment of choice for interstitial pregnancies. A very limited number of articles pre have explored the use of intravenous methotrexate to treat cornual pregnancy as a possible conservative first-line therapy in selected, hemodynamically stable patients.
  
  
  METHODS
  A patient with a confirmed interstitial pregnancy was treated with intravenous methotrexate. The patient's beta-hCG levels decreased to zero within 9 weeks.
  
  
  CONCLUSIONS
  Intravenous methotrexate was used successfully in the treatment of an interstitial pregnancy without complications.
authors.affiliation: Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, and Columbus Hospital, Newark, New Jersey 07101-1709, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Al-Khan
authors.forename: Roger
authors.initials: R
authors.lastname: Jones
authors.forename: Donald
authors.initials: D
authors.lastname: Fricchione
authors.forename: Joseph
authors.initials: J
authors.lastname: Apuzzio
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D005493:Folic Acid Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D005494:Folic Acid Deficiency / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D007262:Infusions, Intravenous; D008727:Methotrexate / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005493:Folic Acid Antagonists; D008727:Methotrexate