title: Sex differences in thermal nociception and prostaglandin-induced thermal hypersensitivity in rhesus monkeys.
abstract: The present study examined thermal nociception in 4 male and 4 female rhesus monkeys. In the first experiment, monkeys were tested 5 days/week for 4 consecutive weeks in a warm-water, tail-withdrawal assay of thermal nociception. Thermal nociception did not vary by sex or menstrual cycle phase. However, male monkeys tended to be slightly more sensitive to thermal stimuli than female monkeys in the follicular phase of the menstrual cycle. Thermal nociception did not correlate with estradiol or progesterone levels in female monkeys. In the second experiment, thermal hypersensitivity was induced by administering prostaglandin E(2) (0.0032 to 0.1 mg subcutaneously) into the tail. Prostaglandin E(2) produced slightly greater thermal hypersensitivity in male than in follicular phase female monkeys, but male and luteal phase female monkeys did not differ, and there was not a significant difference between follicular and luteal phase female monkeys. Exposure to the behavioral procedures produced similar increases in blood levels of the stress-related hormones adrenocorticotropic hormone and cortisol in male and female monkeys, which suggests that measures of thermal nociception or thermal hypersensitivity were not confounded by sex differences in stress responses. These results suggest that sex and gonadal hormone levels have only a minor influence on thermal nociception or thermal hypersensitivity in rhesus monkeys.
  
  
  CONCLUSIONS
  These modest effects of sex and gonadal hormone levels on measures of pain in non-human primates could be interpreted to support the hypothesis that sex differences in pain perception in humans are due more to sociocultural factors than to a biological imperative.
authors.affiliation: Alcohol and Drug Abuse Research Center, Harvard Medical School-McLean Hospital, Belmont, MA 02478, USA. negus@mclean.harvard.edu
authors.forename: S Stevens
authors.initials: SS
authors.lastname: Negus
authors.forename: Brooke A
authors.initials: BA
authors.lastname: Wurrey
authors.forename: Nancy K
authors.initials: NK
authors.lastname: Mello
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006358:Hot Temperature; D006854:Hydrocortisone / Q000097:blood; D006930:Hyperalgesia / Q000503:physiopathology*; D008253:Macaca mulatta; D008297:Male; D008597:Menstrual Cycle / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010120:Oxytocics / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D012727:Sex Characteristics; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D010120:Oxytocics; D011374:Progesterone; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D015232:Dinoprostone; D006854:Hydrocortisone