title: Diffusion MRI findings in neonatal brain abscess.
abstract: In neonates and infants, bacterial brain abscess is rare, and the diffusion weighted MR imaging appearance of such abscesses has not been reported. We report the diffusion weighted MR findings of a brain abscess in a 25-day-old boy. The lesion initially had a large cystic component with some high-signal pyogenic material inside on diffusion-weighted (b=1000 sec/mm(2))images. The ADC value of this material was low (0.59 x 10(-3) mm(2)/sec), compared to the value from normal cerebellar parenchyma (0.78 x 10(-3) mm(2)/sec). The unusual initial appearance mimicked a cystic tumor. The lesion markedly decreased in size over 20 days after antibiotic therapy with persistent high-signal pyogenic material. In addition, at the initial presentation b=1000 sec/mm(2) images revealed high-signal changes in the brain parenchyma compressed by markedly dilated ventricles, consistent with ischemia. Also, ADC values of perilesional vasogenic edema (1.74 x 10(-3) mm(2)/sec), and that of transependymal resorption of CSF (1.56 x 10(-3) mm(2)/sec) were noted at the initial stage.
authors.affiliation: Department of Radiology, Ege University Hospital, Bornova, 35100, Izmir, Turkey. rnsener@med.ege.edu.tr
authors.forename: R N
authors.initials: RN
authors.lastname: Sener
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis* / Q000188:drug therapy; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging; D005500:Follow-Up Studies; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000188:drug therapy; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents