title: 99mTc-HMPAO distribution at SPECT is associated with succinate-cytochrome c reductase (SCR) activity in subjects with psychiatric disorders.
abstract: The origin of altered (99m)Tc-HMPAO distribution at SPECT in psychiatric disorders is unknown. Correlations between brain (99m)Tc-HMPAO distribution and muscle succinate-cytochrome c reductase (SCR, complex II + III) were assessed in 20 unmedicated psychiatric patients. Significant negative correlations were found between (99m)Tc-HMPAO distribution in associative sensory regions and SCR activity. Sensory cortices are normally enriched in complex II activity. The production of electrons and reactive oxygen species affecting the redox state is considered to be highest from complex III, but complex II may also contribute. The negative relationship between (99m)Tc-HMPAO uptake and SCR activity may be due to redox state alterations influencing fixation of the radiopharmaceutical.
authors.affiliation: NEUROTEC Department, Section of Psychiatry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. agardner@swipnet.se
authors.forename: Ann
authors.initials: A
authors.lastname: Gardner
authors.forename: Marco
authors.initials: M
authors.lastname: Pagani
authors.forename: Henning
authors.initials: H
authors.lastname: Beier
authors.forename: Hans
authors.initials: H
authors.lastname: Jacobsson
authors.forename: Stig A
authors.initials: SA
authors.lastname: Larsson
authors.forename: Tore
authors.initials: T
authors.lastname: Hällström
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000000981:diagnostic imaging / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000201:enzymology*; D018482:Muscle, Skeletal / Q000201:enzymology*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013223:Statistics as Topic; D013384:Succinate Cytochrome c Oxidoreductase / Q000378:metabolism*; D019690:Technetium Tc 99m Exametazime / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D013384:Succinate Cytochrome c Oxidoreductase