title: MRI findings of hypoxic cortical laminar necrosis in a child with hemolytic anemia crisis.
abstract: We present magnetic resonance imaging findings of a 5-year-old girl who had a rapidly installing hemolytic anemia crisis induced by trimethoprim-sulfomethoxazole, resulting in cerebral anoxia leading to permanent damage. Magnetic Resonance imaging revealed cortical laminar necrosis in arterial border zones in both cerebral hemispheres, ischemic changes in subcortical white matter of left cerebral hemisphere, and in the left putamen. Although cortical laminar necrosis is a classic entity in adulthood related to conditions of energy depletions, there are few reports available in children. A wide review of the literature is also presented.
authors.affiliation: Department of Radiology, Division of Neuroradiology, Cerrahpasa Medical Faculty, 34300 Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Kizilkilic
authors.forename: Sait
authors.initials: S
authors.lastname: Albayram
authors.forename: Ozgür
authors.initials: O
authors.lastname: Kasapcopur
authors.forename: Ismail
authors.initials: I
authors.lastname: Mihmanli
authors.forename: Naci
authors.initials: N
authors.lastname: Kocer
authors.forename: Civan
authors.initials: C
authors.lastname: Islak
mesh_terms: D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D002545:Brain Ischemia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009336:Necrosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy