Allogeneic bone marrow transplantation with non-T-cell-depleted marrow from two HLA-antigen-mismatched related donors.
Allogeneic BMT from 2 antigen-mismatched donors has been difficult to perform without T-cell depletion. Seven patients with advanced-stage hematologic malignancies underwent BMT with intensified graft-versus-host disease prophylaxis consisting of tacrolimus, methotrexate, and methylprednisolone. No rejection or acute GVHD >or= grade III was observed. This preliminary result is very promising.
Ogawa
Hiroyasu
H
Ikegame
Kazuhiro
K
Kawakami
Manabu
M
Taniguchi
Yuki
Y
Oka
Yoshihiro
Y
Kawase
Ichiro
I
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006680:HLA Antigens / Q000276:immunology*; D006648:Histocompatibility; D006801:Humans; D008212:Lymphocyte Depletion; D008297:Male; D014019:Tissue Donors; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
D006680:HLA Antigens