Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
The relative stereochemistry of the 22-membered marine macrolide dictyostatin, a Taxol-like antimitotic agent, was determined based on a combination of extensive high field NMR studies, including J-based configuration analysis, and molecular modelling.
Paterson
Ian
I
University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. ip100@cam.ac.uk
Britton
Robert
R
Delgado
Oscar
O
Wright
Amy E
AE
D000818:Animals; D018942:Macrolides / Q000737:chemistry* / Q000494:pharmacology; D008870:Microtubules / Q000737:chemistry* / Q000187:drug effects; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
D018942:Macrolides; C470814:dictyostatin