[Activity of the anthelmintic agent trichlorophen on the models of human helminthiasis].
Trials of trichlorophen have shown its high efficacy on models of cestode infections: hymenolepiasis (at the adult and cysticercoid stages of development on three types of animals: outbred albino mice, albino rats and golden hamsters), preimaginal echinococciasis alveolaris, larval alveolar echinococciasis (at the early stage of development of the parasite in experiments on cotton rats). The high nematodical activity of trichlorophen was first found on models of trichocephaliasis in DBA/2y mice, nippostrongyloidiasis (in in vitro experiments), and aspiculuriasis in outbred mice. The agent proved to be ineffective at the tissue developmental stage of Hymenolepsis nana (H. nana), the dwarf tapeworm, in albino mice, during experimental opisthorchiasis in golden hamsters. It showed a low efficacy in treating trichinosis in outbred albino mice. Unlike carbamatebenzimidazoles, trichlorophen was inactive at the tissue stage of H. nana; it exerted no effects on the eggs of a dwarf tapeworm in trichinosis. Trichlorophen was also inactive in treating experimental opisthorchiasis in golden hamsters.
Astaf'ev
B A
BA
Lebedeva
M N
MN
Mikhaĭlitsyn
F S
FS
Kovalenko
F P
FP
Gitsu
G A
GA
Dzhabarova
V I
VI
Fedianina
L V
LV
Veretennikova
N L
NL
Lykova
N I
NI
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D002590:Cestode Infections / Q000188:drug therapy; D002733:Chlorophenols / Q000008:administration & dosage / Q000627:therapeutic use*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006373:Helminthiasis / Q000188:drug therapy* / Q000469:parasitology; D006926:Hymenolepis / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008811:Mice, Inbred DBA; D009349:Nematode Infections / Q000188:drug therapy; D009559:Nippostrongylus / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012426:Russia
D000871:Anthelmintics; D002733:Chlorophenols