Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa.
Sterile-male-release technique is currently used to control the sea lamprey (Petromyzon marinus) population in the Great Lakes. The chemosterilant (bisazir) used in this program is extremely hazardous; special safety measures are necessary when handling this chemical. Therefore, replacement of bisazir with safer agents is desirable. In this study, we examined the effects of low-toxicity compounds with previously described spermicidal activity (mainly against mammalian sperm) on motility and fertilizing ability of sea lamprey spermatozoa. Nonoxynol-9, benzalkonium chloride, zinc acetate, cupric chloride, cysteamine, tannic acid and propranolol were able to inhibit both sperm motility and fertilizing ability. Effective concentrations of these spermicides ranged from 0.15 to 1%. Therefore, they can be potentially used in further study directed at in vivo sterilization of male sea lampreys.
Ciereszko
Andrzej
A
Semen Biology Group, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, Olsztyn 10-747, Poland.
Babiak
Igor
I
Dabrowski
Konrad
K
D000818:Animals; D001548:Benzalkonium Compounds / Q000008:administration & dosage; D019826:Cholic Acid / Q000008:administration & dosage; D003300:Copper / Q000008:administration & dosage; D003543:Cysteamine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005306:Fertilization / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D047348:Hydrolyzable Tannins / Q000008:administration & dosage; D007798:Lampreys; D008297:Male; D017137:Nonoxynol / Q000008:administration & dosage; D009994:Osmolar Concentration; D011433:Propranolol / Q000008:administration & dosage; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000494:pharmacology*; D013094:Spermatozoa / Q000187:drug effects*; D019345:Zinc Acetate / Q000008:administration & dosage
D001548:Benzalkonium Compounds; D047348:Hydrolyzable Tannins; D013089:Spermatocidal Agents; D017137:Nonoxynol; D003543:Cysteamine; D003300:Copper; D011433:Propranolol; D019345:Zinc Acetate; D019826:Cholic Acid; C029892:cupric chloride