Acute lymphoblastic leukemia with hypereosinophilia: report of a case with 5q deletion and review of the literature.
Peripheral blood eosinophilia as a presentation of acute lymphoblastic leukemia (ALL) has only rarely been reported. The eosinophilia is thought to be a nonneoplastic reaction to the neoplastic lymphoblasts. We present the case of a 5-year-old girl who developed peripheral hypereosinophilia with no circulating blasts prior to her diagnosis of B-cell lineage ALL. Cytogenetic study showed a hyperdiploid blast population with 5q deletion. Persistent peripheral hypereosinophilia should always be fully investigated, the possibility of a malignancy including ALL needs to be excluded, even in the absence of peripheral cytopenias and circulating blasts.
Wynn
Tung T
TT
Section of Hematology/Oncology, Columbus Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Heerema
Nyla A
NA
Hammond
Sue
S
Ranalli
Mark
M
Kahwash
Samir B
SB
D002675:Child, Preschool; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011014:Pneumonia / Q000209:etiology* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D017384:Sequence Deletion