title: No association of G-463A myeloperoxidase gene polymorphism with MPO-ANCA-associated vasculitis.
abstract: BACKGROUND
  The activation of neutrophils and monocytes by ANCA, resulting in the release of reactive oxygen species and proteases like myeloperoxidase (MPO), is essential to the pathogenesis of ANCA-associated vasculitis. As the A allele of the G-463A MPO gene polymorphism is associated with diminished activity of MPO, it is conceivable that the presence of this allele protects against MPO-ANCA-associated vasculitis.
  
  
  METHODS
  Allelic frequencies of the G-463A polymorphism were studied in 119 ANCA-associated vasculitis patients, 48 with MPO-ANCA and 71 with proteinase 3 (PR3)-ANCA.
  
  
  RESULTS
  Allelic frequencies of MPO G-463A promoter polymorphism did not differ between MPO-ANCA- and PR3-ANCA-associated vasculitis patients. Moreover, allelic distribution was similar to that of the normal population.
  
  
  CONCLUSIONS
  The data suggest that G-463A polymorphism does not seem to contribute to either MPO-ANCA- or PR3-ANCA-associated vasculitis formation.
authors.affiliation: Department of Nephrology, Medical School Hannover, D-30623 Hannover, Germany.
authors.forename: Anette
authors.initials: A
authors.lastname: Fiebeler
authors.forename: Stefan
authors.initials: S
authors.lastname: Borgmann
authors.forename: Alexander
authors.initials: A
authors.lastname: Woywodt
authors.forename: Hermann
authors.initials: H
authors.lastname: Haller
authors.forename: Marion
authors.initials: M
authors.lastname: Haubitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D014657:Vasculitis / Q000097:blood* / Q000235:genetics*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase