Structural proteomics: a tool for genome annotation.
In any newly sequenced genome, 30% to 50% of genes encode proteins with unknown molecular or cellular function. Fortunately, structural genomics is emerging as a powerful approach of functional annotation. Because of recent developments in high-throughput technologies, ongoing structural genomics projects are generating new structures at an unprecedented rate. In the past year, structural studies have identified many new structural motifs involved in enzymatic catalysis or in binding ligands or other macromolecules (DNA, RNA, protein). The efficiency by which function is deduced from structure can be further improved by the integration of structure with bioinformatics and other experimental approaches, such as screening for enzymatic activity or ligand binding.
Yakunin
Alexander F
AF
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada.
Yee
Adelinda A
AA
Savchenko
Alexei
A
Edwards
Aled M
AM
Arrowsmith
Cheryl H
CH
D004247:DNA / Q000378:metabolism; D016678:Genome; D006801:Humans; D008670:Metals / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D012313:RNA / Q000378:metabolism
D008670:Metals; D011506:Proteins; D012313:RNA; D004247:DNA