Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.
Enhanced release of proinflammatory cytokines may contribute to the pathogenesis of ischemic stroke. Interleukin-1 receptor antagonist (IL-1Ra) is an anti-inflammatory cytokine, and tumor necrosis factor (TNF)-alpha and IL-1beta are proinflammatory cytokine. To determine the role of cytokines in genetic susceptibility to ischemic stroke, we genotyped ischemic stroke patients (n = 152) and the healthy control subjects (n = 165) for IL-1Ra, TNF-alpha and IL-1beta polymorphism by polymerase chain reaction-restriction fragment length polymorphism methods. The analysis shown the association of IL1RN*1, IL1RN*2 allele (IL1RN*1, OR=0.44, P = 0.0206 IL1RN*2, OR=2.90, P = 0.0141) and TNF1, TNF2 allele (TNF1, OR=2.16, P = 0.0225; TNF2, OR=2.16, P = 0.0225) to ischemic stroke. However, the genetic polymorphism of IL-1beta was not associated with ischemic stroke. Our results suggest that IL-1Ra and TNF-alpha gene polymorphism is associated with the susceptibility to ischemic stroke.
Lee
Byung-Cheol
BC
Department of Oriental Internal Medicine, College of Medicine, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Ku, Seoul 130-701, South Korea.
Ahn
Se-Young
SY
Doo
Ho-Kyung
HK
Yim
Sung-Vin
SV
Lee
Hee-Jae
HJ
Jin
Sheng-Yu
SY
Hong
Seung-Jae
SJ
Lee
Sang-Ho
SH
Kim
Sung-Do
SD
Seo
Jung-Chul
JC
Leem
Kang-Hyun
KH
Chung
Joo-Ho
JH
D002545:Brain Ischemia / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D004660:Encephalitis / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology; D007723:Korea; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012795:Sialoglycoproteins / Q000235:genetics* / Q000276:immunology; D020521:Stroke / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000276:immunology
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha