title: Radio-guided occult lesion localization in patients undergoing breast-conserving surgery and sentinel node biopsy.
abstract: BACKGROUND
  The objective of the study was to evaluate the feasibility of radio-guided occult lesion localization (ROLL) in breast-conserving surgery for nonpalpable breast cancer.
  
  
  METHODS
  Altogether 215 breast cancer patients were included in a prospective study. Ultrasonographically guided intratumoral injection of radioactive tracer was used for tumor localization in 64 patients with nonpalpable tumors, visible in breast ultrasonography (the ROLL group). Nonpalpable tumors, visible only in mammography, were localized with a help of a guidewire in 14 patients (the WGR group). The remaining 137 patients had palpable tumors.
  
  
  RESULTS
  The proportion of specimens with close or involved margins (0 to 3 mm) was the same in the ROLL group (6%) and among cases with palpable tumors (5%). In addition the median length of the closest margin did not differ significantly between the groups.
  
  
  CONCLUSIONS
  The results of ROLL for nonpalpable breast cancer are comparable with those for resection of palpable tumors.
authors.affiliation: Breast Surgery Unit, Maria Hospital, Helsinki University Hospital, Helsinki, Finland. ritta.ronka@pp.fimnet.fi
authors.forename: Riitta
authors.initials: R
authors.lastname: Rönkä
authors.forename: Leena
authors.initials: L
authors.lastname: Krogerus
authors.forename: Esa
authors.initials: E
authors.lastname: Leppänen
authors.forename: Karl
authors.initials: K
authors.lastname: von Smitten
authors.forename: Marjut
authors.initials: M
authors.lastname: Leidenius
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery*; D005240:Feasibility Studies; D006801:Humans; D008408:Mastectomy / Q000379:methods*; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy; D014463:Ultrasonography