Antioxidative constituents from Lycopus lucidus.
Three phenolic compounds, rosmarinic acid (1), methyl rosmarinate (2), ethyl rosmarinate (3), and two flavonoids, luteolin (4), luteolin-7-O-beta-D-glucuronide methyl ester (5) were isolated from the aerial part of Lycopus lucidus (Labiatae). Their structures were determined by chemical and spectral analysis. Compounds 1-5 exhibited potent antioxidative activity on the NBT superoxide scavenging assay. The IC50 values for compounds 1-5 were 2.59, 1.42, 0.78, 2.83, and 3.05 microg/mL respectively. In addition, five compounds were isolated from this plant for the first time.
Woo
Eun-Rhan
ER
College of Pharmacy, Chosun University, Gwangju 501-759, Korea. wooer@chosun.ac.kr
Piao
Mei Shan
MS
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D002855:Chromatography, Thin Layer; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D031333:Lycopus / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009580:Nitroblue Tetrazolium; D010936:Plant Extracts / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000975:Antioxidants; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010936:Plant Extracts; D009580:Nitroblue Tetrazolium