title: [Effects of one Chinese herbs on improving cognitive function and memory of Alzheimer's disease mouse models].
abstract: OBJECTIVE
  To investigate Chinese herbs with the effect on significantly improving the cognitive function and retention of patients with Alzheimer's disease.
  
  
  METHODS
  AD mouse models were established by injecting poly-beta-AP25-35 into the cerebral ventricle of mice. The curative effects of traditional Chinese herbs Dangguishaoyaosan, Chaihujialonggumulitang and two herbs (CHP I and CHP II) developed by the authors on improving the memory and cognitive function of AD mouse models were studied by the detection of behavioral and histochemical tests, with piracetam serving as control.
  
  
  RESULTS
  CHP II has profound curative effects on improving the memory and cognitive function of AD-like animal model.
  
  
  CONCLUSIONS
  The present study indicates that it has a satisfactory prospect to seek new drugs from Chinese herbs to treat AD.
authors.affiliation: Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Zhang
authors.forename: Shi-you
authors.initials: SY
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D029023:Acorus / Q000737:chemistry; D000544:Alzheimer Disease / Q000139:chemically induced / Q000523:psychology*; D000818:Animals; D001921:Brain / Q000473:pathology; D003071:Cognition / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D032305:Lycium / Q000737:chemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012153:Retention, Psychology / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C413220:toki-shakuyaku-san