title: Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.
abstract: Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.
authors.affiliation: Department of Medicine, School of Medicine, University of California, San Diego, California 92103, USA.
authors.forename: Judd W
authors.initials: JW
authors.lastname: Landsberg
authors.forename: Jason X-J
authors.initials: JX
authors.lastname: Yuan
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology / Q000503:physiopathology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D011651:Pulmonary Artery / Q000166:cytology*; D050052:TRPC Cation Channels
chemical_list: D015220:Calcium Channels; D050052:TRPC Cation Channels