In vivo MR spectroscopy in diagnosis and research of neuropsychiatric disorders.
Magnetic resonance spectroscopy is one of the most important tools for quantitative analysis of chemical composition and structure, and this non-invasive technique is now being applied in vivo to study biochemical processes in those neuropsychiatric disorders that are part of the phospholipid spectrum. Interpretation of a clinical magnetic resonance spectrum can provide information about membrane phospholipid turnover, cellular energetics, neuronal function, selected neurotransmitter activity and intracellular pH. Cerebral proton and phosphorus magnetic resonance spectroscopy findings are summarized in relation to schizophrenia, dyslexia and chronic fatigue syndrome.
Cox
I J
IJ
Faculty of Medicine, Imaging Sciences Department, Imperial College London, Division of Clinical Sciences, Robert Steiner Magnetic Resonance Unit, Hammersmith Campus, Du Cane Road, London W12 0HS, UK. j.cox@imperial.ac.uk
Puri
B K
BK
D004410:Dyslexia / Q000175:diagnosis; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009497:Neurotic Disorders / Q000175:diagnosis*; D012559:Schizophrenia / Q000175:diagnosis