title: [Liver involvement revealing systemic mastocytosis: report of two cases].
abstract: Systemic mastocytosis is a disease defined by an abnormal infiltration of mast cells involving several extra-cutaneous organs. Hepatic involvement is frequent, however it rarely reveals the disease. We report two cases of systemic mastocytosis revealed by hepatic symptoms: liver failure in one case and jaundice in the second case. The diagnosis is often difficult. Mast cell tissular infiltration can be identified on paraffin sections by tryptase or CD117 (c-kit) immuno-staining.
authors.affiliation: Service d'Anatomie et cytologie pathologiques, Hôpital Jean Verdier, AP-HP, Avenue du 14 juillet, 93143 Bondy Cedex. dominique.wendum@sat.ap-hop-paris.fr
authors.forename: Dominique
authors.initials: D
authors.lastname: Wendum
authors.forename: Sophie
authors.initials: S
authors.lastname: Prevot
authors.forename: Armelle
authors.initials: A
authors.lastname: Poujol-Robert
authors.forename: Olivier
authors.initials: O
authors.lastname: Rosmorduc
authors.forename: Jean
authors.initials: J
authors.lastname: Cabane
authors.forename: Loïc
authors.initials: L
authors.lastname: Fouillard
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Flejou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D034721:Mastocytosis, Systemic / Q000150:complications* / Q000473:pathology