title: The shark HoxN cluster is homologous to the human HoxD cluster.
abstract: The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.
authors.affiliation: Bioinformatik, Institut für Informatik, Universität Leipzig, Kreuzstrassse 7b, D-04103 Leipzig, Germany.
authors.forename: Sonja J
authors.initials: SJ
authors.lastname: Prohaska
authors.forename: Claudia
authors.initials: C
authors.lastname: Fried
authors.forename: Chris T
authors.initials: CT
authors.lastname: Amemiya
authors.forename: Frank H
authors.initials: FH
authors.lastname: Ruddle
authors.forename: Günter P
authors.initials: GP
authors.lastname: Wagner
authors.forename: Peter F
authors.initials: PF
authors.lastname: Stadler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016000:Cluster Analysis; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D005801:Genes, Homeobox / Q000235:genetics*; D006801:Humans; D010802:Phylogeny; D017385:Sequence Homology; D012754:Sharks / Q000235:genetics*