title: A mechanistic model for the aging of human skin.
abstract: The microinflammatory model of skin aging is described. This model accounts for the loss of elasticity, resiliene and flexibility of the dermis, as well as for the appearance of wrinkles and for the thinning of the epidermis which are associated with aging. The lack of appropriate apparatuses for the correct measurements of skin hydration does not allow one to test this model for its predictive capability of the appearance of dry skin with age. The micro-inflammatory model of skin aging fails to predict the appearance of age spots on the surface of the skin.
authors.affiliation: Clinique Laboratories, Inc and Estee Lauder Research Park, 125 Pinelawn Road, Melville, NY 11747, USA. pgiacomo@estee.com
authors.forename: Paolo U
authors.initials: PU
authors.lastname: Giacomoni
authors.forename: Glen
authors.initials: G
authors.lastname: Rein
mesh_terms: D003872:Dermatitis / Q000473:pathology; D004548:Elasticity; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis / Q000502:physiology; D008019:Life Style; D008954:Models, Biological; D018384:Oxidative Stress; D018583:Pliability; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D015595:Skin Aging / Q000502:physiology*; D012880:Skin Pigmentation; D013472:Sunlight / Q000009:adverse effects
chemical_list: D018799:Intercellular Adhesion Molecule-1