[Clinical value of some factors of gene transcription in heart diseases].
Two families of gene transcription factors - these review deals with peroxisome proliferator activated receptors (PP AR) and nuclear factor kappa B (NFkappaB). PPAR family controls lipid metabolism, processes of inflammation and atherothrombosis. Activation of NFkappaB initiates transcription of genes of such proinflammatory factors as cytokines, chemokines and adhesion molecules. NFkappaB plays substantial role in processes of apoptosis, ischemic preconditioning, myocardial injury in ischemia and reperfusion, development of acute coronary syndromes and cardiac failure. Clinical perspectives of drugs affecting these gene transcription factors are also discussed.
Kagan-Ponomarev
M Ia
MIa
Cardiology Research Complex, ul. Tretiya Cherepkovskaya 15a, 121552 Moscow, Russia.
D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use; D005656:Fungal Proteins / Q000187:drug effects / Q000235:genetics; D006331:Heart Diseases / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D052002:NF-kappa B p50 Subunit; D014157:Transcription Factors / Q000187:drug effects / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics*
D002316:Cardiotonic Agents; D005656:Fungal Proteins; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human; C079787:NUC-1 protein, Neurospora crassa; D014157:Transcription Factors