The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer.
Beta-transducin repeats-containing proteins (beta-TrCP) serve as the substrate recognition subunits for the SCFbeta-TrCP E3 ubiquitin ligases. These ligases ubiquitinate specifically phosphorylated substrates and play a pivotal role in the regulation of cell division and various signal transduction pathways, which, in turn, are essential for many aspects of tumorigenesis. We review the functions of the SCFbeta-TrCP ligases in the light of their relevance to cell growth, survival and transformation. Mechanisms underlying beta-TrCP regulation and their aberration in human and animal cancer as well as prospective of targeting beta-TrCP as a means of anticancer therapy are also discussed.
Fuchs
Serge Y
SY
Department of Animal Biology, University of Pennsylvania, 3800 Spruce Street, Rm 161E, Philadelphia, PA 19104, USA. sfuks@vet.upenn.edu
Spiegelman
Vladimir S
VS
Kumar
K G Suresh
KG
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008025:Ligases / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics*; D013379:Substrate Specificity; D014452:Ubiquitins / Q000378:metabolism*; D044844:beta-Transducin Repeat-Containing Proteins / Q000235:genetics / Q000378:metabolism*
D014452:Ubiquitins; D044844:beta-Transducin Repeat-Containing Proteins; D008025:Ligases