Effect of harmane on mononeuropathic pain in rats.
This study was designed to investigate the effect of the endogenous beta-carboline, harmane, on neuropathic pain produced by chronic constriction injury (CCI) of the sciatic nerve. Thermal allodynia evaluations were made preoperatively, postoperatively on the fifteenth day, and after harmane administration. Harmane (1, 2.5, 5, 10, or 20 mg/kg) was administered intraperitoneally for 5 days beginning from postoperative day 15. Treatment with harmane had a profound anti-allodynic effect in a dose-dependent manner. In conclusion, harmane might provide a new approach to treatment of neuropathic pain.
Aricioglu
Feyza
F
Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpasa, Istanbul, Turkey. feyzak@turk.net
Korcegez
Eylem
E
Ozyalcin
Suleyman
S
D000818:Animals; D002243:Carbolines / Q000378:metabolism / Q000627:therapeutic use; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D006247:Harmine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000473:pathology
D002243:Carbolines; D006247:Harmine; C005010:harman