[Effect of Astragalus membranaceus on baroreflex sensitivity in spontaneously hypertensive rats].
OBJECTIVE
To observe the chronicity decompression effect of Astragalus Membranaceus(AM) and evaluate the effect on baroreflex sensitivity (BRS).


METHODS
Nineteen spontaneously hypertensive rats(SHR) were randomly divided into four groups. The AM groups were intraperitoneally administered with AM parenteral solution 0.9 mL, 1.2 mL and 1.8 mL respectively and the control group was not given AM for eight weeks. Then the change of blood pressure was observed successivly. After eight weeks, BRS were also determined. At last, the difference of blood pressure and BRS among the groups were compared.


RESULTS
Blood pressure in the control group became higher and higher frome the third week to the eighth week, but the other SHR admistered with AM showed no changein blood pressure level. We also found that the BRS in AM group was higher than that in the control group(P < 0.01).


CONCLUSIONS
AM can promote the BRS in SHR.
Chen
Zhi-kui
ZK
Department of Cardiovascular, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, Zhejiang, China.
Hu
Shen-jiang
SJ
Zhen
Xia
X
Wang
Guo-bing
GB
Sun
Jian
J
Xia
Qiang
Q
Sheng
Yue-liang
YL
D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D027885:Astragalus propinquus / Q000737:chemistry; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal