title: Notch signaling in T- and B-cell development.
abstract: The Notch family of evolutionarily conserved proteins regulates a broad spectrum of cell-fate decisions and differentiation processes during fetal and post-natal development. The best characterized role of Notch signaling during mammalian hematopoiesis and lymphopoiesis is the essential function of the Notch1 receptor in T-cell lineage commitment. More recent studies have addressed the roles of other Notch receptors and ligands, as well as their downstream targets, revealing additional novel functions of Notch signaling in intra-thymic T-cell development, B-cell development and peripheral T-cell function.
authors.affiliation: The Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. Freddy.Radtke@isrec.unil.ch
authors.forename: Freddy
authors.initials: F
authors.lastname: Radtke
authors.forename: Anne
authors.initials: A
authors.lastname: Wilson
authors.forename: H Robson
authors.initials: HR
authors.lastname: MacDonald
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D051880:Receptors, Notch; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D008565:Membrane Proteins; D051880:Receptors, Notch