1,2-Benzothiazine 1,1-dioxide alpha-ketoamide analogues as potent calpain I inhibitors.
A series of potent 1,2-benzothiazine 1,1-dioxide alpha-ketoamide inhibitors of calpain I is described.
Bihovsky
Ron
R
Department of Medicinal Chemistry, Cephalon, Inc. 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
Tao
Ming
M
Mallamo
John P
JP
Wells
Gregory J
GJ
D000818:Animals; D001921:Brain / Q000378:metabolism; D002154:Calpain / Q000037:antagonists & inhibitors*; D045744:Cell Line, Tumor; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology; D013843:Thiazines / Q000138:chemical synthesis / Q000494:pharmacology*
D013449:Sulfonamides; D013843:Thiazines; D002154:Calpain