Early recurrence of hepatocellular carcinoma after living donor liver transplantation.
Milan criteria are standards for considering the indications of liver transplantation for hepatocellular carcinoma. A 57-year-old man underwent living donor liver transplantation for hepatitis B-related liver cirrhosis and hepatocellular carcinoma. Hepatocellular carcinoma had been treated with percutaneous microwave coagulation therapy and transarterial chemoembolization. Resected specimens revealed a solitary necrotic tumor 5 cm in diameter, which satisfied the Milan criteria. Although the patient survived the operation, he suffered from tumor recurrence in the graft and lung 2 months afterward. Adjuvant chemotherapy had no effect and the patient expired 7 months after transplantation. The present results indicate that a tumor satisfying the Milan criteria does not necessarily guarantee long-term survival after transplantation.
Ohkubo
Takao
T
Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine University of Tokyo, Japan.
Sugawara
Yasuhiko
Y
Imamura
Hiroshi
H
Kaneko
Junichi
J
Matsui
Yuichi
Y
Makuuchi
Masatoshi
M
D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D017809:Fatal Outcome; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery* / Q000628:therapy; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018579:Patient Selection; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D011859:Radiography; D013997:Time Factors; D000509:alpha-Fetoproteins / Q000032:analysis
D015415:Biomarkers; D011498:Protein Precursors; D000509:alpha-Fetoproteins; C008208:acarboxyprothrombin; D011516:Prothrombin