[Antioxidants in complex therapy of atherosclerosis: pro et contra].
The review contains current insights into the role of free radical processes in formation of oxidative stress in atherosclerosis and its relevance to therapy and prevention. Data of epidemiological studies evidence for existence of correlations between blood plasma content of antioxidant vitamins and presence of signs of atherosclerosis. However mostly positive data on the use of antioxidants in various animal experimental models of atherosclerosis contrast with equivocal results of therapeutic application of antioxidant vitamins in humans. Possible causes for this controversy have been choice of suboptimal combinations of components, extremely high concentrations of consumed substances, lack of biochemical testing of baseline antioxidant status and its changes in the process of therapy. The authors of the review suggest novel approaches to planning of clinical trials of antioxidant vitamins.
Lankin
V Z
VZ
Tikhaze
A K
AK
Belenkov
Iu N
IuN
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D002986:Clinical Trials as Topic / Q000592:standards; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D018673:Nutrition Policy; D018384:Oxidative Stress / Q000187:drug effects; D014815:Vitamins / Q000627:therapeutic use
D000975:Antioxidants; D005609:Free Radicals; D014815:Vitamins