Severe metabolic complications from theophylline intoxication.
Theophylline is commonly used in the treatment of bronchospastic lung disease. In addition to gastrointestinal and cardiac dysfunction, hypokalaemia, lactic and ketoacidosis can complicate theophylline overdose. Clinicians frequently fail to identify theophylline's role when complications develop. A case of an 80-year-old man who developed profound metabolic disturbances while hospitalized is presented. The typical causes of these abnormalities were absent, theophylline levels were elevated, and the patient recovered after theophylline was held. Based on our case and review of the literature, we discuss the reasons why theophylline toxicity is under-recognized, and propose mechanisms for the rare metabolic abnormalities identified in this case. A high index of suspicion for theophylline toxicity should be maintained and it should be considered when unexplained acidosis or hypokalaemia occur.
Charytan
David
D
Beth Israel Deaconess Medical Center, Boston, Massachussets 00215, USA. dcharyta@bidmc.harvard.edu
Jansen
Kevin
K
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D000369:Aged, 80 and over; D001639:Bicarbonates / Q000097:blood; D002245:Carbon Dioxide / Q000097:blood; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D007662:Ketosis / Q000139:chemically induced* / Q000378:metabolism / Q000628:therapy; D008297:Male; D010100:Oxygen / Q000097:blood; D010726:Phosphodiesterase Inhibitors / Q000097:blood / Q000633:toxicity*; D011041:Poisoning / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D013806:Theophylline / Q000097:blood / Q000633:toxicity*
D001639:Bicarbonates; D010726:Phosphodiesterase Inhibitors; D002245:Carbon Dioxide; D013806:Theophylline; D010100:Oxygen