Evolution of autosomal suppression of the sex-ratio trait in Drosophila.
The sex-ratio trait is the production of female-biased progenies due to X-linked meiotic drive in males of several Drosophila species. The driving X chromosome (called SR) is not fixed due to at least two stabilizing factors: natural selection (favoring ST, the nondriving standard X) and drive suppression by either Y-linked or autosomal genes. The evolution of autosomal suppression is explained by Fisher's principle, a mechanism of natural selection that leads to equal proportion of males and females in a sexually reproducing population. In fact, sex-ratio expression is partially suppressed by autosomal genes in at least three Drosophila species. The population genetics of this system is not completely understood. In this article we develop a mathematical model for the evolution of autosomal suppressors of SR (sup alleles) and show that: (i). an autosomal suppressor cannot invade when SR is very deleterious in males (c < (1)/(3), where c is the fitness of SR/Y males); (ii). "SR/ST, sup/+" polymorphisms occur when SR is partially deleterious ( approximately 0.3 < c < 1); while (iii). SR neutrality (c = 1) results in sup fixation and thus in total abolishment of drive. So, surprisingly, as long as there is any selection against SR/Y males, neutral autosomal suppressors will not be fixed. In that case, when a polymorphic equilibrium exists, the average female proportion in SR/Y males' progeny is given approximately by ac + 1 - a + a (2) c + 1 (2) + 1 - 4ac /4ac, where a is the fitness of SR/ST females.
Vaz
Suzana Casaccia
SC
Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, CEP 21944-970, Rio de Janeiro, Brazil. suzana@biologia.ufrj.br
Carvalho
Antonio Bernardo
AB
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D005260:Female; D017344:Genes, Insect; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012641:Selection, Genetic; D012744:Sex Ratio; D013489:Suppression, Genetic; D014157:Transcription Factors / Q000235:genetics*; D014960:X Chromosome / Q000235:genetics; D014998:Y Chromosome / Q000235:genetics
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D014157:Transcription Factors; C096359:sr protein, Drosophila