title: De novo internal neoplasms after liver transplantation: increased risk and aggressive behavior in recent years?
abstract: The goal of the study was to determine the incidence and variables associated with post-liver transplantation (LT) de novo internal neoplasms development, excluding skin tumors and hepatocellular carcinoma. Medical records were reviewed for recipient/donor demographics, viral serology, cause of liver disease, interval from LT to tumor diagnosis, predisposing factors, immunosuppression and survival. Forty-one neoplasms (31 solid and 10 hematologic) developed in 772 recipients (5.3%) transplanted between 1991 and 2001. Time to tumor diagnosis was longer in patients transplanted before 1995 than in those transplanted afterwards (58 vs. 22 months; p<0.05). Hematologic neoplasms (HN) appeared earlier than solid (2 vs. 21 months; p<0.001), were more prevalent in those transplanted after 1995 than before (32% vs. 12.5%), and had lower survival than solid (2 vs. 21 months, p<0.001). While HCV was the most frequent indication in HN (70%), alcohol was that of solid tumors (71%). Overall, risk factors for de novo neoplasms included alcohol and immunosuppression (p<0.01). In patients undergoing LT in recent years, there is a higher incidence of HN with de novo internal neoplasms developing at earlier time-points than in those transplanted years ago. Risk factors for tumor development include alcohol, HCV and possibly strong immunosuppression.
authors.affiliation: Department of Hepato-Gastroenterology, Hospital Universitario La Fe, Valencia, Spain. drbenlloch@yahoo.es
authors.forename: Salvador
authors.initials: S
authors.lastname: Benlloch
authors.forename: Marina
authors.initials: M
authors.lastname: Berenguer
authors.forename: Martín
authors.initials: M
authors.lastname: Prieto
authors.forename: Rosalba
authors.initials: R
authors.lastname: Moreno
authors.forename: Fernando
authors.initials: F
authors.lastname: San Juan
authors.forename: Miguel
authors.initials: M
authors.lastname: Rayón
authors.forename: Jose
authors.initials: J
authors.lastname: Mir
authors.forename: Angel
authors.initials: A
authors.lastname: Segura
authors.forename: Joaquín
authors.initials: J
authors.lastname: Berenguer
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents