title: Regulation of B-cell development by antibody specificity.
abstract: Although autoantigen-induced negative selection plays an important role in shaping the mature B-cell repertoire, studies in recent years have suggested that differentiation into any of the three mature B-cell subsets (marginal zone B cells, follicular B cells and B-1 B cells) is not a passive product of autoreactive B-cell elimination. Instead, evidence suggests that entry into a mature subset involves active B-cell receptor signaling and self-antigen-mediated positive selection.
authors.affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Wang
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Clarke
mesh_terms: D000918:Antibody Specificity; D016175:B-Lymphocyte Subsets / Q000276:immunology; D001402:B-Lymphocytes / Q000502:physiology*; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D015398:Signal Transduction
chemical_list: D011947:Receptors, Antigen, B-Cell