title: Propionibacterium acnes lipase in seborrheic dermatitis and other skin diseases and Unsei-in.
abstract: We examined Propionibacterium acnes lipase in skin diseases and Unsei-in. Butyric acid production in axillary seborrheic dermatitis (ASD) was higher than in other dermatitis, and that in acne vulgaris (AV) was significantly higher than in controls. P. acnes lipase is the pathogenic factor in AV and fatty acids produced by lipase might be the pathogenic factor in ASD. Unsei-in suppressed P. acnes lipase probably because some ingredients have antimicrobial and anti-inflammatory activities.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan. shuichi@ms.toyama-mpu.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Higaki
authors.forename: M
authors.initials: M
authors.lastname: Morohashi
mesh_terms: D000328:Adult; D020148:Butyric Acid / Q000378:metabolism; D003872:Dermatitis / Q000382:microbiology*; D012628:Dermatitis, Seborrheic / Q000382:microbiology*; D003879:Dermatologic Agents / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020835:Medicine, Kampo; D011425:Propionibacterium acnes / Q000201:enzymology*; D012867:Skin / Q000737:chemistry / Q000201:enzymology / Q000382:microbiology; D012871:Skin Diseases / Q000382:microbiology*
chemical_list: D003879:Dermatologic Agents; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; C103279:unsei in; D020148:Butyric Acid; D008049:Lipase