Pediatric celiac disease: clinicopathologic and genetic aspects.
Evaluation for celiac disease (CD), an autoimmune enteropathy triggered by grain proteins in wheat, barley, rye, and possibly oats, is a common indication for pediatric endoscopy and biopsy. Duodenal or jejunal biopsy remains key for the initial diagnosis of CD. Small intestinal pathology may be diffuse or focal in CD, and histologic findings are nonspecific and must be interpreted in conjunction with clinical and serologic findings. A standardized grading system for CD biopsies is recommended. This review article summarizes the epidemiology, clinical manifestations, genetics, pathogenesis, and serologic and histologic findings of CD. Clinical management of CD and general handling of small intestinal biopsies are also addressed.
Lowichik
Amy
A
Department of Pathology, Primary Children's Medical Center and University of Utah School of Medicine, 100 North Medical Drive, Salt Lake City, UT 84113, USA. amy.lowichik@ihc.com
Book
Linda
L
D001706:Biopsy; D002446:Celiac Disease; D002648:Child; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007421:Intestine, Small / Q000473:pathology
D006683:HLA-DQ Antigens; C053186:HLA-DQ2 antigen