title: Lower-limb hypoplasia due to intrauterine infection with herpes simplex virus type 2: possible confusion with intrauterine varicella-zoster syndrome.
abstract: A neonate with lower-limb hypoplasia, cutaneous scars, bilateral chorioretinitis, and multiple brain abnormalities is presented. Intrauterine herpes simplex virus type 2 (HSV-2) infection was established on the basis of serological testing of the mother and viral cultures of the child's cutaneous lesions, obtained soon after birth. This is, to the best of our knowledge, the first case of a patient with in utero-acquired HSV-2 infection presenting with a limb hypoplasia. It illustrates that, in addition to congenital varicella-zoster syndrome, HSV-2 infection should also be considered in patients presenting with limb hypoplasia.
authors.affiliation: Neonatal Intensive Care Unit, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium. anne-britt.johansson@huderf.be
authors.forename: A-B
authors.initials: AB
authors.lastname: Johansson
authors.forename: A
authors.initials: A
authors.lastname: Rassart
authors.forename: D
authors.initials: D
authors.lastname: Blum
authors.forename: D
authors.initials: D
authors.lastname: Van Beers
authors.forename: Corinne
authors.initials: C
authors.lastname: Liesnard
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities; D002825:Chorioretinitis / Q000209:etiology; D005260:Female; D006561:Herpes Simplex / Q000503:physiopathology* / Q000821:virology; D006562:Herpes Zoster / Q000151:congenital / Q000503:physiopathology; D018258:Herpesvirus 2, Human; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*