Small molecule antagonists of the tachykinin NK 2 receptor.
The NK(2) receptor (member of the tachykinin receptor family) is mainly located in the smooth muscle of the urinary, respiratory and gastrointestinal tracts, with limited presence in the CNS. This has raised interest in tachykinin NK(2) receptor antagonists for the treatment of urological disorders, asthma. This review outlines progress done after 1998 in the field of NK(2) small molecule antagonists, both acting on the NK(1)/NK(2), NK(2)/NK(3), NK(1)/NK(2)/NK(3) receptors and selective for the NK(2) one.
Fattori
Daniela
D
Chemistry Department, Menarini Ricerche S.p.A, via Tito Speri 10, 00040 Pomezia, Rome, Italy. dfattori@menarini-ricerche.it
Altamura
Maria
M
Maggi
Carlo Alberto
CA
D000818:Animals; D015195:Drug Design; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009130:Muscle, Smooth / Q000378:metabolism*; D064729:Neurokinin-1 Receptor Antagonists; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors*; D012140:Respiratory Tract Diseases / Q000188:drug therapy / Q000378:metabolism; D013329:Structure-Activity Relationship; D014570:Urologic Diseases / Q000188:drug therapy / Q000378:metabolism
D008024:Ligands; D064729:Neurokinin-1 Receptor Antagonists; D018041:Receptors, Neurokinin-2