Fatigue in chronic cholestasis.
Fatigue is probably the most intriguing symptom affecting patients with chronic cholestatic disorders, in particular those with primary biliary cirrhosis. It is postulated that fatigue in patients with primary biliary cirrhosis may be associated with morphological abnormalities of the central nervous system secondary to accumulation of manganese. However, we are still far from understanding this complex issue.
Milkiewicz
P
P
Department of Gastroenterology, Pomeranian Medical School, 71-242 Szczecin, Unii Lubelskiej 1, Poland.
Heathcote
E J
EJ
D001921:Brain / Q000473:pathology; D002779:Cholestasis / Q000150:complications*; D002908:Chronic Disease; D005221:Fatigue / Q000209:etiology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000473:pathology