[Influence of genetic polymorphism of CYP1A1 and GSTM1 on the levels of urinary 1-hydroxypyrene].
In recent years scientific literature has focused the attention on the role of genetic polymorphisms and toxic effects of xenobiotics. Polycyclic Aromatic Hydrocarbons (PAHs) are widely spread xenobiotics, present both in general and work environment. Many papers analysed the influence of the genetic polymorphism of two enzymes involved in the biotransformation of PAHs, Cytochrome P450 1A1 (CYP1A1) and Glutathione S Transferase M1 (GSTM1), on the development of cancer. Some papers analysed also the role of these polymorphisms on the concentration of the biomarker of exposure to PAHs, 1-hydroxypyrene (1OHP). The Institute of Occupational Health and Industrial Hygiene of the University of Brescia focused on this last aspect by EEC project in collaboration with Latin America. In this paper a thorough examination of the general topic and the synthetic project's results are presented.
Neri
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Scuola di Specializzazione in Medicina del Lavoro, Università degli Studi di Brescia. medlav@master.cci.unibs.it
D000293:Adolescent; D000328:Adult; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011721:Pyrenes / Q000378:metabolism*
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D011721:Pyrenes; C033146:1-hydroxypyrene