Cytochrome c, glutathione, and the possible role of redox potentials in apoptosis.
The redox environment of the cell is now thought to be extremely important to control the activity of many proteins. During apoptosis, the intracellular redox potential (E(h)) becomes more positive, with possible consequences for the mechanisms of apoptosis. Glutathione and cytochrome c might both influence and be influenced by the cellular redox environment and therefore be important in the progression of apoptosis.
Hancock
John T
JT
Centre for Research in Plant Science, University of the West of England, Bristol, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom. john.hancock@uwe.ac.uk
Desikan
Radhika
R
Neill
Steven J
SJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002468:Cell Physiological Phenomena; D045304:Cytochromes c / Q000378:metabolism*; D005978:Glutathione / Q000502:physiology*; D008954:Models, Biological; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D045304:Cytochromes c; D005978:Glutathione