Unilateral linear hyperpigmentation of the skin with ipsilateral sectorial hyperpigmentation of the retina.
A 32-year-old Caucasian man had a mosaic hyperpigmentation on his left arm, arranged in a pattern following the lines of Blaschko. In addition, a mosaic hyperpigmentation was noted in his left eye, in the form of grouped congenital hypertrophy of the retinal pigment epithelium (CHRPE). Such "bear tracks" are segmentally oriented, well-demarcated, flat, hyperpigmented lesions originating with small dots at the optic disk and expanding towards the periphery. We hypothesize that these mosaic pigmentary lesions involving the skin and the eye on the same side of the body may have originated from an early postzygotic mutation and thus may be etiologically related.
Meyer
Carsten H
CH
Department of Ophthalmology, Philipp University of Marburg, Marburg, Germany. meyer_eye@yahoo.com
Freyschmidt-Paul
Pia
P
Happle
Rudolf
R
Kroll
Peter
P
D000328:Adult; D006801:Humans; D017495:Hyperpigmentation / Q000235:genetics*; D006984:Hypertrophy; D008297:Male; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012164:Retinal Diseases / Q000151:congenital*; D012880:Skin Pigmentation / Q000235:genetics