title: Oxygen affinity is decreased in patients with polycythaemia vera and essential thrombocythaemia.
abstract: The plasma erythropoietin (EPO) concentration is subnormal in the vast majority of all patients at the time of diagnosis of polycythaemia vera (PV) and in 33-50% of patients with essential thrombocythaemia (ET). At equivalent haemoglobin concentrations patients with PV and a substantial number of ET patients have subnormal EPO concentrations compared with those of healthy subjects. A possible explanation could be altered haemoglobin (Hb) oxygen affinity. Plasma EPO concentration and the oxygen pressure at 50% Hb saturation (p50) were measured in 29 patients with PV, 23 patients with ET and 34 healthy controls. There was no significant correlation between p50 and plasma EPO concentration. However, the mean p50 for PV patients exceeded the mean for healthy controls (p = 0.004). Furthermore, the mean p50 for ET patients significantly (p = 0.012) exceeded the mean for controls but there was no significant difference in p50 between patients with PV and ET. It could be hypothesized that the lower oxygen affinity to Hb in PV and ET patients partly explains the decreased EPO production.
authors.affiliation: Haematology and Coagulation Section, Department of Medicine, Sahlgrenska University Hospital, University of Göteborg, Göteborg, Sweden. peter.l.johansson@vgregion.se
authors.forename: P
authors.initials: P
authors.lastname: Johansson
authors.forename: G
authors.initials: G
authors.lastname: Brudin
authors.forename: B
authors.initials: B
authors.lastname: Nilsson
authors.forename: B
authors.initials: B
authors.lastname: Andréasson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004921:Erythropoietin / Q000097:blood* / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood* / Q000378:metabolism; D010313:Partial Pressure; D011087:Polycythemia Vera / Q000097:blood* / Q000378:metabolism; D013922:Thrombocytosis / Q000097:blood* / Q000378:metabolism
chemical_list: D006454:Hemoglobins; D004921:Erythropoietin; D010100:Oxygen