title: Two successful spontaneous pregnancies in a patient with a primary primitive neuroectodermal tumor of the ovary.
abstract: OBJECTIVE
  To describe a patient with primary primitive neuroectodermal tumor of the ovary with two successful spontaneous pregnancies.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary center for gynecologic oncology.
  
  
  METHODS
  A 25-year-old woman with two spontaneous pregnancies 5 months after and 2 years after conservative treatment of International Federation of Gynecology and Obstetrics stage IC primary primitive neuroectodermal tumor of the ovary.
  
  
  METHODS
  Assessment of extraovarian spread with staging laparotomy. Four courses of BEP (bleomysin, etoposide, cisplatin) and, for recurrent disease, six courses of salvage VIP (vinblastin, iphosphamide, mesna, cisplatin) chemotherapy.
  
  
  METHODS
  Two successful deliveries and no residual ovarian cancer.
  
  
  RESULTS
  A healthy, normal female infant weighing 3600 g was delivered by cesarean section at 38 weeks' gestation. Sixteen months later another infant, a healthy, normal male weighing 3500 g, was delivered by cesarean section at 38 weeks' gestation. No residual cancer was detected at follow-up 12 months after the last delivery.
  
  
  CONCLUSIONS
  Conservative fertility-preserving treatment might be considered in patients with primary primitive neuroectodermal tumor of the ovary. Without any assisted reproductive technologies, spontaneous pregnancies might occur.
authors.affiliation: Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: Ezgi
authors.initials: E
authors.lastname: Demirtas
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.forename: Emine Seda Guvendag
authors.initials: ES
authors.lastname: Guven
authors.forename: Cem
authors.initials: C
authors.lastname: Baykal
authors.forename: Ali
authors.initials: A
authors.lastname: Ayhan
mesh_terms: D000328:Adult; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000503:physiopathology*; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D010052:Ovariectomy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000503:physiopathology*; D014463:Ultrasonography