title: Dedifferentiated chondrosarcoma of the larynx.
abstract: Dedifferentiated chondrosarcoma is an uncommon malignant cartilaginous neoplasm of bone characterized by the presence of a malignant spindle cell neoplasm associated with a low- or medium-grade chondrosarcoma. Origin of this tumor in the cartilagenous framework of the larynx is very rare. A 60-year-old male with a 2-year history of hoarseness and dyspnea was examined while presenting in acute airway distress. Direct laryngoscopy revealed a mass of the right side of the larynx. Histopathologic examination revealed a malignant cartilaginous tumor with a malignant spindle cell component. We report a case of dedifferentiated chondrosarcoma arising in the thyroid cartilage. This, to our knowledge, is the eleventh fully documented case of this neoplasm arising in the larynx.
authors.affiliation: Department of Diagnostic Sciences, University of Medicine and Dentistry of New Jersey-New Jersey Dental School, Newark 07103-2400, USA. rinaggjo@umdnj.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Rinaggio
authors.forename: Dianne
authors.initials: D
authors.lastname: Duffey
authors.forename: H Stan
authors.initials: HS
authors.lastname: McGuff
mesh_terms: D002813:Chondrosarcoma / Q000473:pathology* / Q000556:secondary; D017809:Fatal Outcome; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013957:Thyroid Cartilage / Q000473:pathology*