Regioselective oxidation of 2-amino-3-aroyl-4,5-dialkylthiophenes by DMSO.
Solutions of 2-amino-3-aroyl-4,5-dialkylthiophenes in DMSO (dimethyl sulfoxide) undergo regioselective oxidation of benzylic carbon under mild conditions. We describe three examples and propose a mechanism for oxidation.
Joshi
Elizabeth
E
Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.
Chordia
Mahendra D
MD
Macdonald
Timothy L
TL
Linden
Joel
J
Olsson
Ray
R
D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013876:Thiophenes / Q000737:chemistry*
C490859:ATL-525; C490858:ATL-527; D013876:Thiophenes; C075004:PD 81723; D004121:Dimethyl Sulfoxide