Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation.
Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.
Ekdahl
Kristina N
KN
Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, University Hospital, Uppsala, Sweden.
Bengtsson
Anders A
AA
Andersson
Jonas
J
Elgue
Graciela
G
Rönnblom
Lars
L
Sturfelt
Gunnar
G
Nilsson
Bo
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000378:metabolism; D005172:Factor XI / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D015539:Platelet Activation; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D020246:Venous Thrombosis / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism
D000991:Antithrombins; D001620:beta-Thromboglobulin; D005340:Fibrinogen; D005172:Factor XI