Strategies for dealing with metabolite elucidation in drug discovery and development.
Structural information on metabolites can be a considerable asset for enhancing and streamlining the process of developing new drug candidates. Modern approaches that generate and use metabolite structural information can accelerate the drug discovery and development process by eliminating potentially harmful candidates earlier in the process and improving the safety of new drugs. This review examines the relative merits of current and potential strategies for dealing with metabolite characterization.
Nassar
Alaa-Eldin F
AE
Department of Drug Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. NassarAL@aol.com
Talaat
Rasmy E
RE
D000818:Animals; D001711:Biotransformation; D002986:Clinical Trials as Topic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D010601:Pharmacology, Clinical
D004364:Pharmaceutical Preparations