title: Organic chemistry in drug discovery.
abstract: The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.
authors.affiliation: Department of Basic Chemistry, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. malcolm_maccoss@merck.com
authors.forename: Malcolm
authors.initials: M
authors.lastname: MacCoss
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Baillie
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002625:Chemistry, Organic; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004345:Drug Industry; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D055601:Organic Chemistry Phenomena; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics; D010600:Pharmacology; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical
chemical_list: D004364:Pharmaceutical Preparations