title: [Synthesis and immunostimulating activity of cysteine-containing glycopeptide derivatives of glycyrrhizic acid].
abstract: New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBu(t) dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-type hypersensitivity in mice at a dose of 2 mg/kg. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
authors.affiliation: Bashkortostan State Medical University, Ufa, Bashkortostan, 450074 Russia.
authors.forename: R M
authors.initials: RM
authors.lastname: Kondratenko
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: E V
authors.initials: EV
authors.lastname: Vasil'eva
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: A F
authors.initials: AF
authors.lastname: Ismagilova
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Nasyrov
authors.forename: N Zh
authors.initials: NZh
authors.lastname: Baschenko
authors.forename: R M
authors.initials: RM
authors.lastname: Kireeva
authors.forename: S M
authors.initials: SM
authors.lastname: Fridman
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003545:Cysteine / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019695:Glycyrrhizic Acid / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D019695:Glycyrrhizic Acid; D003545:Cysteine