title: Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release.
abstract: The nitric oxide (NO) donor S-nitrosoglutathione (GSNO) was incorporated in solid polymeric films of poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP) and blended PVA/PVP. These matrices were found to provide a great stabilization effect on the thermal decomposition of GSNO, leading to 8-16-fold reduction in the first-order rate constants of NO release, compared to aqueous GSNO solutions. PVA/PVP-GSNO released 90% of the NO supply, over a time period of 24h at 37 degrees C. Differential scanning calorimetry has confirmed the miscibility between the two polymeric components. Stress-strain analysis has shown an improvement of the mechanical property of PVA films in the PVA/PVP blend, which leads to an increase of 25% in the stress at break. Scanning electron microscopy has shown that the PVA/PVP-GSNO blend leads to a smooth coating of metallic surfaces. These properties, allied to the already known good biocompatibility of PVA and PVP, makes GSNO-containing PVA and PVA/PVP blend films good candidates for the local and controlled release of NO in target areas.
authors.affiliation: Instituto de Quimica, Universidade Estadual de Campinas, UNICAMP, Caixa Postal 6154, 13084-971 Campinas, SP, Brazil.
authors.forename: Amedea Barozzi
authors.initials: AB
authors.lastname: Seabra
authors.forename: Marcelo Ganzarolli
authors.initials: MG
authors.lastname: De Oliveira
mesh_terms: D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D004548:Elasticity; D007700:Kinetics; D008422:Materials Testing; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry*; D011205:Povidone / Q000031:analogs & derivatives* / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature; D013718:Tensile Strength
chemical_list: D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C050762:poly(vinyl alcohol-co-N-vinyl-2-pyrrolidone); D009569:Nitric Oxide; D011142:Polyvinyl Alcohol; D011205:Povidone