[Effects of olprinone hydrochloride after coronary artery bypass grafting].
BACKGROUND
We have examined the effect of olprinone hydrochloride on hemodynamics and peripheral circulation after cardiopulmonary bypass (CPB) in 56 patients who underwent coronary artery bypass grfting.


METHODS
The subjects were randomly classified into 2 groups: B-group of 25 patients who received bolus plus continuous administration of olprinone hydrochloride and control group without administration of olprinone hydrochloride (C-group) of 31 patients. In the B-group, after de-clamping of the aortic occlusion, olprinone hydrochloride 15 micrograms.kg-1 bolus was administered and followed by continuous administration at 0.1 microgram.kg-1.min-1.


RESULTS
We excluded six cases in C-group in whom it was not possible to maintain blood pressure without olprinone hydrochloride. In the B-group, peripheral temperature was kept significantly higher and blood lactic acid value was kept significantly lower until 6 hours after the operation compared with C-group. In the B-group, cardiac index was kept significantly higher for a long period of time, and dosage of concomitantly used catecholamine could be significantly reduced.


CONCLUSIONS
Olprinone increased CI and decreased SVRI, and it led to easy weaning from CPB, providing excellent hemodynamics after CABG. These results suggest that olprinone hydrochloride 15 micrograms.kg-1 bolus plus 0.1 microgram.kg-1.min-1 continuous administration may be effective for improvement of hemodynamics and peripheral circulation after CPB.
Arai
Takero
T
Department of Anesthesiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya 343-8555.
D000368:Aged; D001775:Blood Circulation / Q000187:drug effects; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D011728:Pyridones / Q000008:administration & dosage / Q000494:pharmacology*
D002316:Cardiotonic Agents; D007093:Imidazoles; D011728:Pyridones; D019344:Lactic Acid; C059498:olprinone