title: Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease.
abstract: Mucoadhesive tablets using different mixture of cellulose and polyacrylic derivatives were prepared in order to obtain new formulations containing metronidazole for periodontal disease treatment. All tablets were characterized by swelling studies, ex vivo and in vivo mucoadhesive time, ex vivo mucoadhesion force, in vitro and in vivo release. The best mucoadhesive performance and the best in vitro drug release profile were achieved by using hydroxyethyl cellulose (HEC) and carbomer 940 2:2 ratio. The chosen tablet, containing 20 mg of metronidazole, performed 12 h drug sustained release with buccal concentrations always higher than its MIC.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo, 1, Perugia 06123, Italy. luanaper@unipg.it
authors.forename: Luana
authors.initials: L
authors.lastname: Perioli
authors.forename: Valeria
authors.initials: V
authors.lastname: Ambrogi
authors.forename: Daniela
authors.initials: D
authors.lastname: Rubini
authors.forename: Stefano
authors.initials: S
authors.lastname: Giovagnoli
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ricci
authors.forename: Paolo
authors.initials: P
authors.lastname: Blasi
authors.forename: Carlo
authors.initials: C
authors.lastname: Rossi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics; D000269:Adhesives / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000639:trends; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008795:Metronidazole / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D009061:Mouth Mucosa / Q000187:drug effects; D010510:Periodontal Diseases / Q000145:classification / Q000188:drug therapy*; D012463:Saliva / Q000737:chemistry; D013552:Swine; D013607:Tablets / Q000737:chemistry / Q000493:pharmacokinetics; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D000269:Adhesives; D013607:Tablets; D014867:Water; D008795:Metronidazole; C006903:carbopol 940; D002482:Cellulose; C002283:hydroxyethylcellulose