Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration.
In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
Geloso
Maria Concetta
MC
Institute of Anatomy and Cell Biology, Università Cattolica del S. Cuore, Largo Francesco Vito 1, I-00168 Rome, Italy.
Corvino
Valentina
V
Cavallo
Valentina
V
Toesca
Amelia
A
Guadagni
Enrico
E
Passalacqua
Roberto
R
Michetti
Fabrizio
F
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007381:Intermediate Filament Proteins / Q000096:biosynthesis* / Q000235:genetics; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D064231:Nestin; D051381:Rats; D017208:Rats, Wistar; D014298:Trimethyltin Compounds / Q000633:toxicity*
D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin; D014298:Trimethyltin Compounds; C046488:trimethyltin