Renal outcome of children exposed to cyclosporine in utero.
The number of pregnancies in immunosuppressed women has increased during the recent years and this has become a major part of the rehabilitation and quality of life of treated patients. Most of them are organ transplant recipients and large series from the literature have shown that children born to such women may present with intrauterine growth retardation, a condition which may be associated with significant reduction in nephron number and oligomeganephronia. On the other hand, experimental data in animals have demonstrated that in utero exposure to CsA may alter nephrogenesis and further alter renal function. Therefore offspring of organ transplant women treated with CsA exhibit a theoretical risk of renal impairment, due to both IUGR and fetal nephrotoxicity. However, despite the limited experience of long term studies in children, there is no evidence of any significant deleterious adverse effect of in utero exposure to CsA. However further studies based on large series are required in order to demonstrate that renal fetal effects have limited clinical consequences.
Cochat
P
P
Département de Pédiatrie, Hôpital Edouard-Herriot and Université Claude-Bernard, Lyon, France. pierre.cochat@chu-lyon.fr
Decramer
S
S
Robert-Gnansia
E
E
Dubourg
L
L
Audra
P
P
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000196:embryology*; D016030:Kidney Transplantation / Q000276:immunology; D023421:Models, Animal; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects
D016572:Cyclosporine