title: AgNOR counts in cervical lesions.
abstract: Present study was undertaken with a view to assess the utility of AgNOR counts in differentiating cervical lesions. One hundred cases of cervical lesions including normal, chronic cervicitis, CIN (I, II, III) and carcinoma were taken up for study during the period December 1995 to November 1996. Three micron thick sections of paraffin were subjected to AgNOR staining as described by Crocker and Smith with a little modification of 0.01% safranin counterstain. Statistical counts of AgNORs were done. The mean AgNOR counts in cervical epithelium showed a progressive and statistically significant increase from normal to chronic cervicitis to CIN, I, II and III (P<0.001). Scores in carcinoma also exceeded that of CIN (P<0.05). This can prove to be a useful adjunct to routine histopathology to evaluate cervical lesions.
authors.affiliation: Department of Pathology, IGMC, Shimla.
authors.forename: Rajni
authors.initials: R
authors.lastname: Kaushik
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
authors.forename: Anchana
authors.initials: A
authors.lastname: Gulati
authors.forename: B B
authors.initials: BB
authors.lastname: Sharma
mesh_terms: D002584:Cervix Uteri / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009697:Nucleolus Organizer Region / Q000473:pathology*; D012834:Silver; D013194:Staining and Labeling; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D002575:Uterine Cervicitis / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000473:pathology
chemical_list: D012834:Silver