title: The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis.
abstract: Erp (exported repetitive protein) is a member of a mycobacterium-specific family of extracellular proteins. A hydrophobic region that is localized at the C-terminal domain and that represents a quarter of the protein is highly conserved across species. Here we show that this hydrophobic region is not essential for restoring the virulence and tissue damage of an erp::aph mutant strain of M. tuberculosis as assessed by bacterial counts and lung histology analysis in a mouse model of tuberculosis.
authors.affiliation: Unité de Génétique Mycobactérienne, Institut Pasteur, Paris Cedex 15, F-75724, France.
authors.forename: Dana
authors.initials: D
authors.lastname: Kocíncová
authors.forename: Berit
authors.initials: B
authors.lastname: Sondén
authors.forename: Yann
authors.initials: Y
authors.lastname: Bordat
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Pivert
authors.forename: Leila
authors.initials: L
authors.lastname: de Mendonça-Lima
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gicquel
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Reyrat
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D014397:Tuberculosis, Pulmonary / Q000382:microbiology / Q000473:pathology*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; C096737:ERP protein, Mycobacterium tuberculosis; D008565:Membrane Proteins