title: Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog.
abstract: This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression, thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.
authors.affiliation: Department of Pathologic Anatomy and Forensic Medicine, Section of Pathologic Anatomy, University of Modena and Reggio Emilia, 41100 Modena, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bencini
authors.forename: Mario
authors.initials: M
authors.lastname: Migaldi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Castagnetti
authors.forename: Carlo
authors.initials: C
authors.lastname: Pincelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Ferrari
authors.forename: Carmela
authors.initials: C
authors.lastname: De Gaetani
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Trentini
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D015415:Biomarkers / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D051028:bcl-2-Associated X Protein
chemical_list: C494826:BAX protein, human; C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D051028:bcl-2-Associated X Protein; D007987:Gonadotropin-Releasing Hormone