Imprinted X-chromosome inactivation: enlightenment from embryos in vivo.
There are two forms of X chromosome inactivation (XCI) in the laboratory mouse, random XCI in the fetus and imprinted paternal XCI limited to the extraembryonic tissues supporting the fetal life in utero. Imprinted XCI has been studied extensively because it takes place first in embryogenesis and it may hold clues to the mechanism of control of XCI in general and to the evolution of random' XCI. Classical microscopic and biochemical studies of embryos in vivo provide a basis for interpreting the multifaceted information yielded by various inventive approaches and for planning further experiments.
Takagi
Nobuo
N
Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060-0810, Japan. ntakagi@ees.hokudai.ac.jp
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D004303:Dosage Compensation, Genetic; D004622:Embryo, Mammalian / Q000166:cytology; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D051379:Mice; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism; D014178:Translocation, Genetic; D014960:X Chromosome / Q000235:genetics*
D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; C077885:XIST non-coding RNA