A statistical treatment of biases affecting the estimation of mutation rates.
We consider the estimation of mutation rates, using family data obtained from disputed paternity cases. It is shown how to take appropriate account of a number of complicating features-in particular, hidden mutation, differential mutation, and uncertain paternity-which can necessitate large corrections to simple estimates.
Vicard
P
P
Dipartimento di Economia, Università Roma Tre, Via Ostiense 139, 00154 Roma, Italy.
Dawid
A P
AP
D000483:Alleles; D015982:Bias; D005260:Female; D005554:Forensic Medicine / Q000379:methods; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D010334:Paternity; D010375:Pedigree; D011336:Probability; D020080:Tandem Repeat Sequences / Q000235:genetics