title: Reasons for non-standard treatment in elderly patients with advanced head and neck cancer.
abstract: Elderly patients with head and neck cancer are less likely to receive standard treatment. This study assessed the influence that age, tumour characteristics, comorbidity, social support, depressive symptoms and quality of life have on treatment choice. One hundred and five patients between 45 and 60 years of age and 78 patients of > or =70 years of age with carcinoma of the oral cavity (stage > or =II), oro- and hypopharynx (stage > or =II) or larynx (stage > or =III) completed a questionnaire on quality of life (EORTC QLQ-C30 and H&N35), depressive symptoms (CES-D) and social support (RSS12-I). In the 45-60 age group, 89% received standard treatment, compared with 62% of the > or =70 age group. A multivariate logistic regression analysis showed that the following factors predicted non-standard treatment: marital status (widowed), advanced tumour stage, comorbidity, less pain, considering the length of life less important than its quality and old age. This study showed that age itself independently influences treatment choice. However, it should be emphasised that the choice of a treatment should be based on a medical assessment and the patient's preferences, not on chronological age.
authors.affiliation: Department of Otorhinolaryngology, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands. w.derks@azu.nl
authors.forename: W
authors.initials: W
authors.lastname: Derks
authors.forename: J R J
authors.initials: JR
authors.lastname: de Leeuw
authors.forename: G J
authors.initials: GJ
authors.lastname: Hordijk
authors.forename: J A M
authors.initials: JA
authors.lastname: Winnubst
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000523:psychology / Q000628:therapy*; D003863:Depression / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000523:psychology / Q000628:therapy*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000523:psychology / Q000628:therapy; D007822:Laryngeal Neoplasms / Q000523:psychology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000523:psychology / Q000628:therapy; D011788:Quality of Life; D012944:Social Support; D011795:Surveys and Questionnaires