title: The existence of a putative post-transcriptional regulatory element in 3'-UTR of Drosophila antibacterial peptide diptericin's mRNA.
abstract: Antibacterial peptides' genes are rapidly and transiently expressed on immune stimulation, which is the characteristic of immediate early genes. It implies post-transcriptional regulation is an important pathway in antibacterial peptides' gene expression. In a search of putative post-transcriptional regulatory elements, we found a segment of an AU-rich sequence in 3'-untranslated region (UTR) of drosophila diptericin mRNA. 3'-UTR of diptericin mRNA can be specifically bound with Elav and this binding can be competed with the typical AU-rich element (ARE) of c-fos mRNA. These results suggest that the AU-rich sequence in the 3'-UTR of diptericin mRNA may be a cis-acting element and involved in post-transcriptional regulation.
authors.affiliation: Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Second Medical University, 225 South Chongqing Road, Shanghai 200025, PR China.
authors.forename: Hai-Xu
authors.initials: HX
authors.lastname: Chen
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.forename: Zhao-Zhao
authors.initials: ZZ
authors.lastname: Jiang
authors.forename: Xian-Ming
authors.initials: XM
authors.lastname: Qu
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Yang
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Ma
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D051959:ELAV Proteins; D017781:Genes, Immediate-Early; D005809:Genes, Regulator; D019476:Insect Proteins / Q000235:genetics*; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics; D012261:Ribonucleoproteins / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D023181:Antimicrobial Cationic Peptides; C054756:DptA protein, Drosophila; D029721:Drosophila Proteins; D051959:ELAV Proteins; D019476:Insect Proteins; D012333:RNA, Messenger; D012261:Ribonucleoproteins