title: Detoxifying cancer causing agents to prevent cancer.
abstract: Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of synergistic action of the natural source compounds known to inhibit one or more stages of carcinogenesis, that is, initiation and promotion/progression. Many natural cancer preventive agents are effective inhibitors of tumor initiation, promotion, and/or progression. The mechanism of action is related to their abilities to prevent critical carcinogen metabolism and to increase detoxification of carcinogens and tumor promoters. The authors review here the potential role of the detoxification system and, in particular, the roles of D-glucaric acid and the enzyme beta-glucuronidase in early detection and prevention of cancer. There is now growing evidence for the possible control of different stages of the cancer induction by inhibiting beta-glucuronidase with D-glucaric acid derivatives, especially with its salts (D-glucarates). D-Glucaric acid has been found in many vegetables and fruits. Therefore, the consumption of fruits and vegetables naturally rich in D-glucaric acid or self-medication with D-glucaric acid derivatives such as calcium D-glucarate offers a promising cancer prevention approach.
authors.affiliation: AMC Cancer Research Center, Denver, CO 80214, USA. hanausekm@amc.org
authors.forename: Margaret
authors.initials: M
authors.lastname: Hanausek
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Walaszek
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage; D015415:Biomarkers / Q000032:analysis; D018890:Chemoprevention / Q000379:methods; D004032:Diet; D019587:Dietary Supplements; D005937:Glucaric Acid / Q000097:blood; D005966:Glucuronidase / Q000097:blood; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D009374:Neoplasms, Experimental; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D015415:Biomarkers; D005966:Glucuronidase; D005937:Glucaric Acid