Transduction peptides: from technology to physiology.
During the past fifteen years, a variety of peptides have been characterized for their ability to translocate into live cells. Most are efficient vectors that can internalize hydrophilic cargoes, and so provide a valuable biological (and potentially therapeutic) tool for targeting proteins into cells. Furthermore, translocation of cell-permeable peptides across the plasma membrane and their subsequent access to the cytosol, even when fused to large hydrophilic proteins, is challenging the perception of the plasma membrane as an impermeable barrier.
Joliot
Alain
A
Homeoprotein Cell Biology Group, CNRS UMR 8542, Ecole Normale Supérieure, 46 rue d'Ulm, 75230 Paris, Cedex 05 France. joliot@wotan.ens.fr
Prochiantz
Alain
A
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000502:physiology; D005822:Genetic Vectors / Q000502:physiology; D006801:Humans; D010455:Peptides / Q000378:metabolism* / Q000493:pharmacokinetics*; D015202:Protein Engineering / Q000379:methods / Q000639:trends; D017434:Protein Structure, Tertiary / Q000502:physiology; D021381:Protein Transport / Q000187:drug effects* / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000378:metabolism / Q000493:pharmacokinetics; D014161:Transduction, Genetic / Q000379:methods* / Q000639:trends
D010455:Peptides; D011993:Recombinant Fusion Proteins