title: Congenital syphilis in an immunocompromised neonate: case report.
abstract: Syphilis is a notifiable and preventable disease, congenital syphilis more so. Consequently, attention has been recently focused on prenatal diagnosis of foetal syphilis by the use of ultrasonography apart from the conventional serologic screening. Congenital syphilis has not been reported from the Kingdom of Lesotho. We report the case of a 3.0 kg male neonate with florid joint and bone lesions of congenital syphilis associated with HIV infection seen at the Queen Elizabeth II Hospital, Maseru, Kingdom of Lesotho. Co-existing HIV infection influences the clinical manifestation of syphilis, the progression of neurosyphilis and the response to standard therapy. The baby had the recommended standard treatment with good response and he was followed-up for a period of twelve months with serologic screening and radiographic evaluation.
authors.affiliation: Queen Elizabeth II Hospital, Maseru, Kingdom of Lesotho.
authors.forename: A M O
authors.initials: AM
authors.lastname: Shonubi
authors.forename: B A
authors.initials: BA
authors.lastname: Salami
authors.forename: D O
authors.initials: DO
authors.lastname: Oloruntoba
authors.forename: P
authors.initials: P
authors.lastname: Mohaleroe
authors.forename: S A
authors.initials: SA
authors.lastname: Agbahowe
mesh_terms: D015492:AIDS Serodiagnosis; D017088:AIDS-Related Opportunistic Infections / Q000151:congenital* / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007927:Lesotho; D008297:Male; D008403:Mass Screening; D010400:Penicillin G / Q000627:therapeutic use; D013588:Syphilis Serodiagnosis; D013590:Syphilis, Congenital / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome; D016216:Ultrasonography, Prenatal
chemical_list: D000900:Anti-Bacterial Agents; D010400:Penicillin G