Helicobacter pylori-mediated gastritis induces local downregulation of secretory leukocyte protease inhibitor in the antrum.
Helicobacter pylori-infected subjects exhibited a strong decline in antral secretory leukocyte protease inhibitor (SLPI) levels compared to H. pylori-negative subjects and subjects from whom H. pylori had been eradicated (P = 0.002). This reduction was specific for the antrum, whereas SLPI expression in corpus and duodenum was not affected. Antral SLPI levels were inversely correlated with inflammatory scores of antrum-predominant gastritis.
Wex
Thomas
T
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, D-39120 Magdeburg, Germany. thomas.wex@medizin.uni-magdeburg.de
Treiber
Gerhard
G
Nilius
Manfred
M
Vieth
Michael
M
Roessner
Albert
A
Malfertheiner
Peter
P
D000328:Adult; D015536:Down-Regulation; D005260:Female; D005756:Gastritis / Q000382:microbiology / Q000503:physiopathology*; D016481:Helicobacter Infections / Q000503:physiopathology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins / Q000378:metabolism*; D011706:Pyloric Antrum / Q000378:metabolism*; D053481:Secretory Leukocyte Peptidase Inhibitor
D053491:Proteinase Inhibitory Proteins, Secretory; D011506:Proteins; C506814:SLPI protein, human; D053481:Secretory Leukocyte Peptidase Inhibitor