Could condensin scaffold the mitotic chromosome?
One of the most remarkable and yet poorly understood events during the cell cycle is how dispersed chromatin fragments are transformed into chromosomes every time cells undergo mitosis. It has been postulated that mitotic chromosomes might contain an axial scaffold that is involved in condensation but its molecules and structure have remained elusive. Recent data suggests that the condensin complex might indeed be an essential part of the scaffold that provides a platform for other proteins to localize and promote different aspects of chromosome condensation.
Coelho
Paula A
PA
Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal.
Queiroz-Machado
Joana
J
Sunkel
Claudio E
CE
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D020090:Chromosome Segregation; D002875:Chromosomes / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D046911:Macromolecular Substances; D008938:Mitosis / Q000502:physiology*; D046912:Multiprotein Complexes; D009690:Nucleic Acid Conformation
D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D046912:Multiprotein Complexes; C108312:condensin complexes; D000251:Adenosine Triphosphatases