title: Long-term follow-up of cervical dystonia patients treated with botulinum toxin A.
abstract: We followed the course in 100 consecutive patients with cervical dystonia (CD) after they were initially treated with botulinum toxin (BTX) in the form of Dysport 10 to 12 years ago. A total of 4 patients had died, and 6 were lost to follow-up. Of the remaining 90 patients, 57 (63%) were still treated with BTX. In the patients treated at one centre over the whole period with Dysport, mean dose used during each treatment session was 833 (SD +/- 339) units Dysport with a cumulative dose of 20,943 (SD +/- 9462) units Dysport over a mean of 26.8 (SD +/- 8.6) treatment cycles. Secondary nonresponse was detected in 3 of the 90 patients. During follow-up, 12 patients developed blepharospasm, 13 oromandibular dystonia, and 17 patients writer's cramp. We conclude that BTX remains effective and safe for approximately 60% of CD patients for more than 10 years.
authors.affiliation: Department of Neurology, Klinkum rechts der Isar, Technische Universität München, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Haussermann
authors.forename: Stefanie
authors.initials: S
authors.lastname: Marczoch
authors.forename: Christiane
authors.initials: C
authors.lastname: Klinger
authors.forename: Michael
authors.initials: M
authors.lastname: Landgrebe
authors.forename: Bastian
authors.initials: B
authors.lastname: Conrad
authors.forename: Andres
authors.initials: A
authors.lastname: Ceballos-Baumann
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D020821:Dystonic Disorders / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008538:Meige Syndrome / Q000139:chemically induced; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013997:Time Factors; D014103:Torticollis / Q000188:drug therapy* / Q000453:epidemiology
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A