title: Effects of a 4-week 70% high carbohydrate/15% low fat diet on glucose tolerance and on lipid profiles.
abstract: In order to investigate the effect of high carbohydrate/low fat diet on glucose tolerance and on lipid profiles, we performed a 4-week crossover study. Japanese subjects (30 patients with type 2 diabetes mellitus, 15 subjects with impaired glucose tolerance and 8 subjects with normal glucose tolerance) were allocated either 55% standard carbohydrate/30% fat (sc) or 70% high carbohydrate/15% low fat (hc) diet for four weeks, and evaluated by OGTT and various parameters. Then, the diet was crossed over to another diet, and identical parameters were re-evaluated after four weeks. Area under the glucose concentration-time curve (AUG) or triglyceride did not show significant changes between the two diets. HDL-Cholesterol and body mass index decreased significantly by hc diet. Free fatty acids and homeostasis model assessment insulin resistance index showed a tendency to be decreased by hc diet. AUG hc/sc ratio was inversely correlated with AUG or free fatty acids on standard carbohydrate diet. In conclusion, the present 4-week high carbohydrate/low fat diet may be useful to reduce body weight and insulin resistance. The 4-week high carbohydrate/low fat diet did not affect glucose tolerance as a whole. Although the 4-week high carbohydrate/low fat diet decreased HDL-Chol, it did not increase triglyceride.
authors.affiliation: Third Department of Internal Medicine, Yamanashi Medical University, Shimokato 1110, Tamaho, Yamanashi 409-3898, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Komiyama
authors.forename: Takehiro
authors.initials: T
authors.lastname: Saito
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hosaka
authors.forename: Kaoru
authors.initials: K
authors.lastname: Aida
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Akio
authors.initials: A
authors.lastname: Sato
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Onaya
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Masato
authors.initials: M
authors.lastname: Tawata
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy; D018752:Diet, Fat-Restricted; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified; D008055:Lipids