title: Accessing natural products by combinatorial biosynthesis.
abstract: Enhancement and selective production of the protein phosphatase IIa inhibitor phoslactomycin (PLM) B by rational engineering of the PLM biosynthetic pathway highlights the effectiveness of combinatorial biosynthesis as a promising way to prepare complex natural products and their analogs.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. bshen@pharmacy.wisc.edu
authors.forename: Ben
authors.initials: B
authors.lastname: Shen
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends*; D012107:Research Design / Q000639:trends*