Progress in clinical neurosciences: Parkinson's disease with dementia and dementia with Lewy bodies.
Dementia occurs in up to 30% of people with Parkinson's disease and is a major cause of disability. Pathologically, Parkinson's dementia, where dementia follows the onset of parkinsonism by at least one year, overlaps with dementia with Lewy bodies. We review the functional impact, definitions, neuropsychology, epidemiology and pathophysiology of Parkinson's dementia, dementia with Lewy bodies and their overlap. Associated psychiatric and imaging findings are also considered. Lastly, current and emerging approaches to assessment and treatment in patients with these Lewy body associated dementias are presented.
Camicioli
Richard
R
Department of Medicine, Division of Neurology, University of Alberta, Glenrose Rehabilitation Hospital, Edmonton, Alberta, Canada.
Fisher
Nancy
N
D003704:Dementia / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009488:Neurosciences / Q000379:methods / Q000639:trends*; D010300:Parkinson Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy