title: Does laparoscopic fundoplication provide long-term control of gastroesophageal reflux related cough?
abstract: BACKGROUND
  Of patients with chronic cough, 21% have GERD. Up to half of these patients may not respond adequately to medical, but the long-term results of antireflux surgery for cough is unknown.
  
  
  METHODS
  A total of 905 patients (209 with respiratory symptoms, mainly cough) underwent laparoscopic Nissen fundoplication. Preoperatively patients underwent esophageal motility studies, 24-h pH monitoring, and symptom evaluation using a validated scale. Of eligible patients, 81% were followed at 6 months, 73% at 2 years, and 60% at 5 years.
  
  
  RESULTS
  Before surgery, 83% of respiratory patients (RP) and 51% of nonrespiratory patients (NRP) had cough. RP had higher cough scores ( p < 0.0001), but improvement in cough compared to baseline was similar in the RP and NRP ( p = 0.1105 at 6 months, 0.4206 at 2 years, and 0.1348 at 5 years). Cough improved in 83% at 6 months, 74% at 2 years, and 71% at 5 years.
  
  
  CONCLUSIONS
  Laparoscopic Nissen fundoplication is successful in the long-term control of GERD-related cough, even in patients who fail medical therapy.
authors.affiliation: Department of Medicine, St Joseph's Healthcare-McMaster University, 50, Charlton Avenue East, Hamilton, ON, L8N 4A6, Canada.
authors.forename: C J
authors.initials: CJ
authors.lastname: Allen
authors.forename: M
authors.initials: M
authors.lastname: Anvari
mesh_terms: D000328:Adult; D003371:Cough / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods* / Q000706:statistics & numerical data; D005764:Gastroesophageal Reflux / Q000150:complications / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012008:Recurrence; D016896:Treatment Outcome