In vivo and in vitro effects of different anaesthetics on platelet function.
Different effects of thiopental, propofol and sevoflurane on platelets have been reported. Patients undergoing thyroid surgery were anaesthetized with thiopental-fentanyl-sevoflurane (n = 11) or propofol-fentanyl-sevoflurane (n = 9). Platelet aggregation and thromboxane A2 generation were studied at baseline, and at the end of anaesthesia induction and surgery. Dose-response experiments were also performed in vitro with single agents. Thiopental-fentanyl-sevoflurane significantly reduced collagen-induced aggregation by the end of induction, while ADP-induced aggregation and thromboxane generation were unaffected. Propofol-fentanyl-sevoflurane had no effect on platelets. Thiopental dose-dependently inhibited platelets in vitro, while fentanyl or propofol did not. In conclusion, thiopental reduces platelet function both ex vivo and in vitro and propofol might be considered haemostatically safer.
Dordoni
Pier Lorenza
PL
Department of Anaesthesiology, Catholic University School of Medicine, Rome Research Center on Pathophysiology of Haemostasis, Catholic University School of Medicine, Rome, Italy.
Frassanito
Luciano
L
Bruno
Maria F
MF
Proietti
Rodolfo
R
de Cristofaro
Raimondo
R
Ciabattoni
Giovanni
G
Ardito
Guglielmo
G
Crocchiolo
Roberto
R
Landolfi
Raffaele
R
Rocca
Bianca
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D019162:Anesthetics, Combined / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011184:Postoperative Period; D015742:Propofol / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology; D013928:Thromboxane A2 / Q000096:biosynthesis
D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D013928:Thromboxane A2; D013874:Thiopental; D015742:Propofol