Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder.
BACKGROUND
Neuroimaging reports of increases in signal hyperintensities in white and deep gray matter and other work indicate that there might be an inflammatory response in affective disorders.


METHODS
The microvascular immunoreactivity of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 was measured with image analysis in postmortem tissue from the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) from 15 unipolar and 15 bipolar subjects and compared with each other and with 15 subjects with schizophrenia and 15 control subjects.


RESULTS
Intercellular adhesion molecule-1 immunoreactivity in gray and white matter of the ACC in bipolar subjects was increased compared with control subjects (gray: p =.001; white: p <.001) and schizophrenic subjects (gray: p =.016; white: p =.025) and modestly increased in white matter compared with unipolar subjects (p =.049). No such differences were found in the DLPFC.


CONCLUSIONS
These findings are consistent with the presence of an inflammatory response in the ACC in bipolar disorder.
Thomas
Alan J
AJ
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK.
Davis
Sue
S
Ferrier
I Nicol
IN
Kalaria
Rajesh N
RN
O'Brien
John T
JT
D000328:Adult; D001714:Bipolar Disorder / Q000378:metabolism*; D016022:Case-Control Studies; D003710:Demography; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000378:metabolism; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism
D018799:Intercellular Adhesion Molecule-1