title: Food intake with an antiobesity drug (sibutramine) versus placebo and rorschach data: a crossover within-subjects study.
abstract: We related the effect of the satiety enhancing drug sibutramine (Meridia, Reductil) on food intake to Rorschach Comprehensive System (Exner, 1991, 1993) personality factors. A placebo-controlled crossover, within-subjects design (n = 36) was used. Food intake after 2 weeks in the sibutramine and placebo conditions was assessed with a test meal using the VIKTOR (Cabmek, Stockholm, Sweden) setup, a computerized eating monitor. Building on baseline VIKTOR measurements, we had earlier studied the microstructure of eating (Elfhag, Barkeling, Carlsson, & Rossner, 2003). In this study, a model including Afr, MOR, and Populars could explain the variance in the effect of sibutramine. Sibutramine may reduce food intake in single test meals for participants whose appetite is prompted by external stimuli including food cues, suggested by the Affective ratio. Distress related to the body in obesity seen in damaged self-imagery (MOR) and adjustment to social expectations (Populars) could also have a moderating effect on the participants' consumption of test meals in an experimental design. Bodily concern (An + Xy) was also related to sibutramine response in univariate analyses.
authors.affiliation: Obesity Unit, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. Kristina.Elfhag@medhs.ki.se
authors.forename: Kristina
authors.initials: K
authors.lastname: Elfhag
authors.forename: Britta
authors.initials: B
authors.lastname: Barkeling
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Carlsson
authors.forename: Thomas
authors.initials: T
authors.lastname: Lindgren
authors.forename: Stephan
authors.initials: S
authors.lastname: Rossner
mesh_terms: D000328:Adult; D001067:Appetite Depressants / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003503:Cyclobutanes / Q000627:therapeutic use*; D004435:Eating; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D010919:Placebos; D012392:Rorschach Test; D013548:Sweden
chemical_list: D001067:Appetite Depressants; D003503:Cyclobutanes; D010919:Placebos; C058254:sibutramine