Choline pivaloyl esters improve in rats cognitive and memory performances impaired by scopolamine treatment or lesions of the nucleus basalis of Meynert.
The effects of two choline pivaloyl esters, [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium iodide (1) and [2-(2,2-dimethylpropionyloxy)ethyl]trimethylammonium 2,2-dimethylpropionate (2), on learning and memory impairments induced in rats by scopolamine or lesions of nucleus basalis magnocellularis (NBM) have been evaluated by object recognition and Morris water maze tests in comparison with Tacrine (THA). Both 1 and 2 restored discrimination in object recognition test for assessing working-episodic memory and improved spatial memory in scopolamine or NBM-lesioned rats as well. The positive effects produced by 1 and 2 on cognitive and memory deficits were well comparable with those evoked by THA, used as reference compound.
Rispoli
Vincenzo
V
Department of Scienze Farmacobiologiche, University of Catanzaro Magna Graecia, Complesso Ninì Barbieri, 88021 Roccelletta di Borgia (CZ), Italy. rispoli@unicz.it
Rotiroti
Domenicantonio
D
Carelli
Vincenzo
V
Liberatore
Felice
F
Scipione
Luigi
L
Marra
Rosario
R
Giorgioni
Gianfabio
G
Di Stefano
Antonio
A
D000110:Acetylcholinesterase / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D020532:Basal Nucleus of Meynert / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D002452:Cell Count; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004193:Discrimination Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004952:Esters / Q000627:therapeutic use; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D011427:Propiophenones / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine; D013037:Spatial Behavior / Q000187:drug effects; D013619:Tacrine / Q000494:pharmacology; D013997:Time Factors
C484885:(2-(2,2-dimethylpropionyloxy)ethyl)trimethylammonium; D002800:Cholinesterase Inhibitors; D004952:Esters; D011427:Propiophenones; D000644:Quaternary Ammonium Compounds; C034349:metamfepramone; C009571:phenyltrimethylammonium; D013619:Tacrine; D012601:Scopolamine; D000110:Acetylcholinesterase; D002794:Choline