Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women.
Plasma adiponectin concentrations were measured before and after moderate weight loss in 20 obese women, divided at baseline into insulin-resistant (IR) and insulin-sensitive (IS) subgroups on the basis of their steady-state plasma glucose (SSPG) concentration at the end of a 180-minute infusion of octreotide, glucose, and insulin. The groups were similar in age and body weight and lost comparable amounts of weight (8 to 9 kg) during the weight loss period. Fasting plasma insulin and SSPG concentrations were significantly higher (P <.001) and adiponectin concentrations somewhat lower (P =.10) in the IR group (P <.001) at baseline. Both SSPG and plasma insulin concentrations decreased in IR subjects (P <.001), but did not change in IS individuals. Adiponectin concentrations did not change with weight loss in either group. Thus, neither weight loss, per se, nor enhanced insulin sensitivity resulted in a change in plasma adiponectin concentrations.
Abbasi
Fahim
F
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lamendola
Cindy
C
McLaughlin
Tracey
T
Hayden
John
J
Reaven
Gerald M
GM
Reaven
Peter D
PD
D052242:Adiponectin; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011506:Proteins / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology*
D052242:Adiponectin; D001786:Blood Glucose; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins