title: The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine.
abstract: The effect of chlorpromazine (CPZ) on the neurosecretory action of the hypothalamo- hypophyseal system was investigated in 72 male rats. The experimental animals received CPZ in a dose of 0.4 mg, 4.0 mg and 20.0 mg/kg b.w. for 30 days. The rats were sacrificed by decapitation at 24 h and 7 days after the last dose of the drug. The neurosecretory material was stained with paraldehyde fuchsin in the supraoptic nucleus, paraventricular nucleus, eminentia mediana and neurohypophysis, the tigroid was stained with toluidine blue and the acid phosphatase activity was evaluated histoenzymatically. It was found that CPZ reduced the content of the neurosecretory material after 24 h, while an increase was observed 7 days after the last drug administration.
authors.affiliation: Department of Histology and Embryology, Medical University, Białystok, Poland. earcisz@amb.edu.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Arciszewska
authors.forename: Halina
authors.initials: H
authors.lastname: Borowska
authors.forename: Bogusław
authors.initials: B
authors.lastname: Sawicki
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006651:Histocytochemistry; D007032:Hypothalamus, Anterior / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D009489:Neurosecretion / Q000187:drug effects*; D009490:Neurosecretory Systems / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D051381:Rats
chemical_list: D014150:Antipsychotic Agents; D000135:Acid Phosphatase; D002746:Chlorpromazine