Molecular Koch's postulates applied to bacterial pathogenicity--a personal recollection 15 years later.
Koch's postulates were derived from Robert Koch's work on infectious diseases, such as anthrax and tuberculosis, which still engage us to this day. These guidelines were an attempt to establish a standard for identifying the specific causation of an infectious disease and to convince sceptics that microorganisms could cause disease. They were also established to encourage an increasing number of novice microbiologists to use more rigorous criteria before claiming a causal relationship between a microorganism and a disease.
Falkow
Stanley
S
Stanford University School of Medicine, Stanford, California 94305-5124, USA. falkow@stanford.edu
D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000382:microbiology; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D020411:Oligonucleotide Array Sequence Analysis; D012481:Salmonella Infections, Animal / Q000382:microbiology; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins