title: CT and MR imaging of central nervous system effects of therapy in patients treated for hematological malignancies.
abstract: The purpose of this article is to present the imaging appearance of central nervous system effects of therapy that may occur in patients treated for hematological malignancies. Imaging in these patients relates to complications of high-dose therapy, bone marrow transplantation, infections occurring in immunocompromised patients, central nervous system dysfunction due to failure of other organ systems, or cerebral hemorrhages due to platelet refractoriness. Rapid and accurate diagnosis is essential but often difficult, as neurological manifestations are rarely disease specific. Neurological imaging, in combination with electrophysiological studies as well as blood and cerebrospinal fluid investigations, may be helpful for diagnosing most of these complications, as well as in differentiating between the manifestations of the underlying disease and complications of the treatment.
authors.affiliation: Department of Radiology, Saint-Louis Hospital AP-HP, Paris, France. ali.guermazi@oarg.ucsf.edu
authors.forename: Ali
authors.initials: A
authors.lastname: Guermazi
authors.forename: Yves
authors.initials: Y
authors.lastname: Miaux
authors.forename: François
authors.initials: F
authors.lastname: Lafitte
authors.forename: Jean Ralph
authors.initials: JR
authors.lastname: Zahar
authors.forename: Eliane
authors.initials: E
authors.lastname: Gluckman
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods*