Disappearing calvarium in Gorham disease: MR imaging characteristics with pathologic correlation.
Gorham disease is a rare condition characterized by intraosseous neoplastic proliferation of hemangiomatous tissue with progressive, massive osteolysis. We present a pathologically proved case of Gorham disease that involved the left parietal bone in a 23-year-old man. Imaging studies including conventional radiography of the skull, CT, MR imaging, and Technetium-99 m (Tc-99 m) scintigraphy demonstrated a large skull defect without associated soft tissue mass over the left parietal skull. Contrast enhancement and increased isotope uptake along the margin of the defect were shown at gadolinium-enhanced T1-weighted MR imaging and Tc-99 m methylene diphosphate (Tc-99 m MDP) bone scintigraphy. Pathologic study revealed intraosseous angiomatosis at the periphery of the osteolytic skull lesion.
Lo
Chung-Ping
CP
Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, 325 Sec. 2 Cheng-Kung Road, Neihu 114, Taipei, Taiwan, Republic of China.
Chen
Cheng-Yu
CY
Chin
Shy-Chyi
SC
Juan
Chun-Jung
CJ
Hsueh
Chun-Jen
CJ
Chen
Ann
A
D000328:Adult; D000798:Angiomatosis / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D010014:Osteolysis / Q000175:diagnosis* / Q000473:pathology; D010015:Osteolysis, Essential / Q000175:diagnosis* / Q000473:pathology; D010294:Parietal Bone / Q000473:pathology*; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed
D013669:Technetium Tc 99m Medronate