[Effects of extracts of root of kudzu vine on mammary gland and uterus development in rats].
OBJECTIVE
To study the effects of extracts of root of kudzu vine on mammary gland and uterus development in rats.


METHODS
40 Wistar rats weighting 65-85 g were randomly divided into 4 groups: control group, estrogen group, extracts of root of kudzu vine group of high dose, extracts of root of kudzu vine group of low dose. (10 rats in each group). After having been treated for 7 days, the rats were killed; mammary glands and uterus were removed and weighed. Serum was isolated and kept at 4 degrees C for determination of hormones.


RESULTS
1. Administration of the root of kudzu vine significantly increased the weigh of mammary gland and uterus in rats. 2. Administration of the root of kudzu vine increased serum FSH, LH, E2 and decreased PRL.


CONCLUSIONS
Extracts of root of kudzu vine could enhance the weight of mammary gland and uterus growth in rats, which may provide experimental evidence for the development of new drug used for promoting mammary gland and uterus.
Xue
Xiao-ou
XO
Beijing University of Chinese Traditional Medicine, Beijing 100029, China. xxo123@163.net
Jin
Huan
H
Niu
Jian-zhao
JZ
Wang
Ji-feng
JF
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000254:growth & development*; D009929:Organ Size / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D011388:Prolactin / Q000097:blood; D029908:Pueraria / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000033:anatomy & histology / Q000254:growth & development*
D004365:Drugs, Chinese Herbal; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone