title: Epiphyseal osteoblastoma of tibia with xanthomatous stromal reaction.
abstract: Osteoblastoma occurring in long bones has a distinctive predilection for the metaphysis and the diaphysis. Epiphyseal location is rare. Although variation in histologic patterns is a well-known feature of this tumor, xanthomatous stromal reaction has not yet been described. We report a case of a 34-year-old man who developed an osteoblastoma primarily located in the epiphysis of his left tibia with extension into the metaphysis. The striking histologic features included a prominent xanthoma-like stroma consisting of foamy histiocytes in addition to focal areas with classical configuration of an osteoblastoma. The significance of this finding is discussed.
authors.affiliation: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Zhang
authors.forename: Susan V
authors.initials: SV
authors.lastname: Bukata
authors.forename: John H
authors.initials: JH
authors.lastname: Healey
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Huvos
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D004838:Epiphyses / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D018215:Osteoblastoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D017154:Stromal Cells / Q000473:pathology; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology*; D014973:Xanthomatosis / Q000473:pathology*