Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age.
We measured the effect of chronic ethanol administration on the expression of Glut3 in the cerebellum and hippocampus of adult and old rats. Glut3 expression significantly decreased in aging, in ethanol-treated rats vs. age-matched controls, and in adult- vs. old ethanol-treated rats. These findings lend consistent support to the hypothesis that disturbances of glucose metabolism due to ethanol may constitute an unfavorable condition predisposing to neuronal death.
Fattoretti
P
P
Neurobiology of Aging Laboratory, N. Masera INRCA Research Department, 60121 Ancona, Italy. p.fattoretti@inrca.it
Bertoni-Freddari
C
C
Casoli
T
T
Di Stefano
G
G
Giorgetti
G
G
Solazzi
M
M
D000375:Aging; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002531:Cerebellum / Q000254:growth & development / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology*; D051274:Glucose Transporter Type 3; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology*; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D051381:Rats
D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; C495690:Slc2a3 protein, rat; D000431:Ethanol