[Synthesis of new analogs of 15-ketosterine from ergosterine].
Ergosteryl acetate was converted through three stages into 3 beta-acetoxy-24-methyl-5 alpha-cholesta-8(14),22-diene-15-one in 32% overall yield. The product was transformed to 3 beta-hydroxy-24- methyl-5 alpha-cholesta-8(14),22-diene-15-one, 3 alpha-hydroxy-24-methyl-5 alpha-cholesta-8(14),22-diene-15-one, and 24-methyl-5 alpha-cholesta-8(14),22-diene-3,15-dione. The compounds were characterized by 1H and 13C NMR spectra. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
Misharin
A Iu
AIu
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Pogodinskaya ul. 10, Moscow, 119992 Russia.
Timofeev
V P
VP
D004875:Ergosterol / Q000737:chemistry*; D007664:Ketosteroids / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy
D007664:Ketosteroids; D004875:Ergosterol