title: [Intraarterial chemotherapy with bladder preservation in patients with invasive bladder carcinoma].
abstract: Intraarterial chemotherapy (IAC) was carried out on patients with invasive bladder carcinoma to treat the bladder carcinoma while preserving the bladder. Fifteen patients with bladder carcinoma at stage T2-T4 were treated with intraarterial cisplatin (CDDP: 70 mg/m2) and adriamycin (ADM: 30 mg/m2) every 3 to 4 weeks. The response was observed in all 15 patients. Ten (66.7%) achieved a complete response (CR), and 3 (20.0%) obtained a partial response (PR). With a mean follow-up of 22.6 months, the overall survival rate was 86.7% and 12 patients were alive with functioning bladder. One patient received radical cystectomy. Although further studies and long-term follow up are required to clarify its effectiveness, IAC for patients with invasive bladder carcinoma might be an effective therapy with a preserved bladder.
authors.affiliation: Urologic Clinic, Yao Tokusyukai General Hospital.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shiba
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takatera
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujii
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokizane
authors.forename: Kiyonori
authors.initials: K
authors.lastname: Shimizu
authors.forename: Juichi
authors.initials: J
authors.lastname: Tushima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D004317:Doxorubicin; D002945:Cisplatin