title: Reelin immunoreactivity in the adult sea lamprey brain.
abstract: The expression of reelin, a large extracellular matrix glycoprotein, was studied in the brain of pre-spawning adult sea lampreys by immunohistochemistry using two monoclonal antibodies against this protein. Reelin immunoreactive (reln-ir) neurons were observed in the olfactory bulb, and pallial and subpallial regions in the telencephalon. In the diencephalon, reln-ir cells were observed in some hypothalamic nuclei, in the nucleus of Bellonci, and in the habenula. In the mesencephalon, this protein was detected in several nuclei related with the centrifugal visual system, although the optic tectum was devoid of immunoreactivity. The hindbrain showed several nuclei with immunopositive neurons, including the branchiomeric nerve motor nuclei and also some groups of non-giant cells of the reticular formation. The rostral spinal cord showed some immunopositive neurons mainly located in lateral and ventral positions. Overall, the pattern of distribution of reelin in the adult sea lamprey correlates with the previously reported in other adult vertebrates. Furthermore, the wide distribution of reelin in the adult lamprey brain is consistent with a possible existence of different roles for this protein not related with development in the central nervous system (CNS) of vertebrates (i.e. neuronal plasticity and/or maintenance).
authors.affiliation: Departamento de Biología Celular y Ecología, Area de Biología Celular, Facultad de Biología, Universidad de Santiago de Compostela, Santiago de Compostela 15782, Spain.
authors.forename: Emma
authors.initials: E
authors.lastname: Pérez-Costas
authors.forename: Miguel
authors.initials: M
authors.lastname: Meléndez-Ferro
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Pérez-García
authors.forename: Héctor J
authors.initials: HJ
authors.lastname: Caruncho
authors.forename: María Celina
authors.initials: MC
authors.lastname: Rodicio
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D007150:Immunohistochemistry; D007798:Lampreys / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism; D000091042:Reelin Protein; D012697:Serine Endopeptidases; D013116:Spinal Cord / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D012697:Serine Endopeptidases