title: Platelet-rich plasma for bone graft enhancement in sinus floor augmentation with simultaneous implant placement: patient series study.
abstract: The use of autologous platelet-rich plasma (PRP) as a source for growth factors in bone grafting is a relatively new and promising technique. Early controlled studies indicate that combining PRP with autologous bone grafts significantly enhances the rate of bone formation and maturation. The study consisted of 105 patients who required sinus augmentation with crestal bone height of less than 5 mm in the posterior maxilla. All patients received a composite bone graft that consisted of 30% to 40% autogenous bone harvested from the lateral wall of the maxilla zygomatic-maxillary buttress and the tuberosity and 60% to 70% xenograft. A total of 50 mL of blood was obtained from each patient before the surgical treatment for preparation of 10 mL of PRP. The graft-PRP mixture was activated by human thrombin. All sinus augmentations were carried out simultaneously with dental implants. At 6 months postoperatively, implants were exposed showing no clinical evidence of crestal bone loss around the implants both clinically and radiographically. All implants were clinically osseointegrated and loaded with fixed porcelain fused to metal prosthesis. The use of PRP in augmenting the severely atrophic posterior maxilla has obvious clinical benefits in terms of reducing the healing period of bone maturation, better graft handling, and accelerated soft tissue healing.
authors.affiliation: Division of Oral & Maxillofacial Surgery, University of Miami School of Medicine, Miami, Florida, USA.
authors.forename: Ziv
authors.initials: Z
authors.lastname: Mazor
authors.forename: Michael
authors.initials: M
authors.lastname: Peleg
authors.forename: Arun K
authors.initials: AK
authors.lastname: Garg
authors.forename: Jacob
authors.initials: J
authors.lastname: Luboshitz
mesh_terms: D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001792:Blood Platelets / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation; D003029:Coagulants / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D019094:Dental Prosthesis, Implant-Supported; D005500:Follow-Up Studies; D006801:Humans; D008437:Maxilla / Q000601:surgery*; D008443:Maxillary Sinus / Q000601:surgery*; D016876:Metal Ceramic Alloys; D008875:Middle Aged; D016348:Osseointegration; D017713:Platelet Transfusion; D013917:Thrombin / Q000627:therapeutic use
chemical_list: D018786:Bone Substitutes; D003029:Coagulants; D015921:Dental Implants; D016876:Metal Ceramic Alloys; D013917:Thrombin