[Variants of human immunodeficiency virus type 1, detected in Russia among those infected by the sexual route].
We analyzed 52 blood samples obtained independently from among individuals, who had never practiced the intravenous administration of drugs, for the purpose of detecting the subtypes of HIV-1 that circulated during 1999-2002. The study materials were analyzed by the methods of gag/env heteroduplex mobility assay and by env gp120 C2-V3 sequencing. Four viral subtypes (A,B,C and G) and a recombinant gagA/envB were detected in subjects contaminated through heterosexual contacts. Noteworthily, HIV-1 variations of subtype A, which were found in 22 (73.3%) of 30 analyzed samples, were predominant in this risk group. An analysis of nucleotide sequences exposed a high degree of homology between the viruses, detected previously among drug-addicts, and the isolates detected by us in subjects contaminated heterosexually. However, HIV-1, subtype B, detected by us in all 16 studied cases, still continue to circulate among the males infected through homosexual contacts with men.
Sukhanova
A L
AL
Kazennova
E V
EV
Bobkova
M R
MR
Kravchenko
A V
AV
Selimova
L M
LM
Khanina
T A
TA
Bobkov
A F
AF
Pokrovskiĭ
V V
VV
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000737:chemistry; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry; D010802:Phylogeny; D012426:Russia; D017386:Sequence Homology, Amino Acid; D012725:Sexual Behavior
D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments