[The effect of niaoduqing tablet on the diuresis in normal rats and the hemorheology in blood-stasis rats].
OBJECTIVE
To observe the effect of the Niaoduqing Tablet(NDT) on the diuresis in normal rats and the hemorheology in rats of blood stasis and compare it with the Niaoduqing Granule(NDG), so as to provide some laboratory data for the clinic application and innovation of the dosage forms.


METHODS
Diuretic effect of the NDT on experimental rats burthened with 1% Sodium deoxycholate was observed by using the metabolize cage examination. The changes of whole blood and plasma viscosity in the blood-stasis rat-model were measured with Viscometer-R80. Plasma was separated and fibrinogen measured by using the turbidimetric method.


RESULTS
Every dose of NDT had the diuretic effect on experiment rats, but only the big and middle dose increasing the urine quantity in 6 hours had the significance. Each dose could reduce the viscosity of whole blood and the fibrinogen in the blood-stasis rat model, and had the superiority to NDG.


CONCLUSIONS
NDT has the diuretic effect and can ameliorate the hemorheology in the blood-stasis rat model, which may delay the course of the chronic renal failure (CRF).
Deng
Hong-zhu
HZ
Laboratory of Traditional Medicine Department, First Military Medical University, Guangzhou 510515, Guangdong, China. denghz@fimmu.com
Xiao
Wei
W
Chen
Yu-yao
YY
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D018056:Hemorheology / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013607:Tablets
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D005340:Fibrinogen