[Effect of proton pump inhibitors (PPIs) on wound healing of gastric mucosal cell injury].
The pH-independent effect of PPI such as lansoprazole(LPZ) on cell restitution was shown in vitro. After wounding, addition of LPZ significantly promoted the cell restitution rate. While the addition of MEK inhibitor significantly attenuated the cell restitution rate in the LPZ groups, suggesting that mechanism of cell proliferation and migration promoted by LPZ might involve the activation of p44/p42 MAPK.
Masaoka
Tatsuhiro
T
Department of Internal Medicine, Keio University School of Medicine.
Suzuki
Hidekazu
H
Ishii
Hiromasa
H
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology*; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D054328:Proton Pump Inhibitors; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D009853:Omeprazole