title: Association of progesterone receptor polymorphism with recurrent abortions.
abstract: OBJECTIVE
  The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group.
  
  
  METHODS
  All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed.
  
  
  RESULTS
  Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Leu660Val, exon 5: C2310T His770His). These SNPs are linked. The more frequent wildtype (*1) allele and the rarer (*2) allele were found in the control group and in the study group at different frequencies (control group: *1/*1: 78%, *1/*2: 22%, *2/*2: 0%; patient group: *1/*1: 50%, *1/*2: 43%, *2/*2: 7%). The genotypes distributions differed significantly from each other (P=0.019, chi2=7.879).
  
  
  CONCLUSIONS
  The data suggest that the rarer PR allele may be associated with an increased likelihood of repeated miscarriages contributing to its multi-factorial causes.
authors.affiliation: Division of Gynecological Endocrinology & Reproductive Medicine, Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schweikert
authors.forename: Thomas
authors.initials: T
authors.lastname: Rau
authors.forename: Alexander
authors.initials: A
authors.lastname: Berkholz
authors.forename: Axel
authors.initials: A
authors.lastname: Allera
authors.forename: Sabine
authors.initials: S
authors.lastname: Daufeldt
authors.forename: Ludwig
authors.initials: L
authors.lastname: Wildt
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000235:genetics*
chemical_list: D017931:DNA Primers; D011980:Receptors, Progesterone