title: Vulvar melanoma: a report of 20 cases and review of the literature.
abstract: BACKGROUND
  Vulvar melanoma is the second most common vulvar malignancy and represents a significant women's health issue.
  
  
  OBJECTIVE
  To report experience with 21 cases of vulvar melanoma in 20 patients and to review the literature about the condition.
  
  
  METHODS
  Parameters retrospectively reviewed included age at diagnosis, family history of melanoma, location on the vulva, atypical nevi, Breslow depth, ulceration status, histologic pattern, presenting signs and symptoms, and the results of sentinel lymph node biopsy. Molecular characterization of the melanocortin type 1 receptor was performed in 1 patient.
  
  
  RESULTS
  A family history of cutaneous melanoma was present in 15% of cases. The mean Breslow depth was 2.8 mm (range, 0.0-11.0 mm). Ten patients successfully underwent sentinel lymph node biopsy, results of which were positive in 2 (20%). Reported for the first time is that one patient had a germline mutation in the melanocortin type 1 receptor.
  
  
  CONCLUSIONS
  Vulvar and cutaneous melanoma behave similarly despite their unique pathogeneses. Sentinel lymph node biopsy can be performed successfully for vulvar melanoma.
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Health System, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109-0314, USA.
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Wechter
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Gruber
authors.forename: Hope K
authors.initials: HK
authors.lastname: Haefner
authors.forename: Lori
authors.initials: L
authors.lastname: Lowe
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Schwartz
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Reynolds
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Johnston
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Johnson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology