NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: a description of the trial.
The NSABP-32 trial is a randomized, phase III clinical trial to compare sentinel node (SN) resection to conventional axillary dissection in clinically node-negative breast cancer patients. The primary aims of the trial are to determine if removal of only SNs provides survival and regional control equivalent to those of axillary dissection, while diminishing the magnitude of surgically related side effects. In order to ensure consistency of the outcomes for this trial, a standardized method of SN surgery has been utilized for all cases. A secondary aim of the B32 trial is to evaluate whether patients with "occult" metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients.
Krag
David N
DN
Department of Surgery, University of Vermont, Burlington, Vermont, USA. David.Krag@uvm.edu
Julian
Thomas B
TB
Harlow
Seth P
SP
Weaver
Donald L
DL
Ashikaga
Taka
T
Bryant
John
J
Single
Richard M
RM
Wolmark
Norman
N
D001365:Axilla / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology*; D017326:Clinical Trials, Phase III as Topic; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D016032:Randomized Controlled Trials as Topic; D021701:Sentinel Lymph Node Biopsy