Skeletal muscle hemodynamics and endothelial function in patients after Fontan operation.
To elucidate the relation between exercise capacity and peripheral hemodynamics in patients after the Fontan operation, near-infrared spectroscopy was performed on the vastus lateralis muscle, and flow-mediated vasodilation of the brachial and posterior tibial arteries was done with high-resolution ultrasonography. In Fontan patients, diminished exercise capacity was related to a reduced blood flow supply and an attenuated post-exercise oxygen resaturation of the working skeletal muscle, which also was related to impaired endothelium-dependent vasodilation.
Inai
Kei
K
Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan. satokun-inai-jp@mta.biglobe.ne.jp
Saita
Yoshimasa
Y
Takeda
Sho
S
Nakazawa
Makoto
M
Kimura
Hirotaka
H
D000293:Adolescent; D000328:Adult; D001916:Brachial Artery / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004730:Endothelium, Vascular / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D018729:Fontan Procedure; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism; D011182:Postoperative Care; D012039:Regional Blood Flow; D016909:Tibial Arteries / Q000503:physiopathology*; D018785:Tricuspid Atresia / Q000503:physiopathology* / Q000601:surgery; D014664:Vasodilation / Q000502:physiology
D010100:Oxygen