[The trend of the research on H. pylori eradication and gastric cancer prevention].
The strongest evidence for the association between H. pylori infection and gastric cancer(GC) development in the current is provided by the prospective study that a large number of patients with H. pylori infection were followed with serial endoscopic examinations. Over time, GC was not diagnosed in negative patients. In contrast, the risk for GC was highly increased in positive patients. It was also revealed that in patients with early GC subjected to endoscopic mucosal resection but without eradication therapy, new GC was found in 13% as opposed to only 1% on GC relapse during 8 years in patients with eradication. These studies indicate that some positive patients should be eradicated to reduce the progression of ongoing gastric carcinogenesis.
Uemura
Naomi
N
Department of Gastroenterology, International Medical Center of Japan.
D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D013274:Stomach Neoplasms / Q000209:etiology / Q000517:prevention & control*