title: [Effect of Astragalus membranaceus on baroreflex sensitivity in spontaneously hypertensive rats].
abstract: OBJECTIVE
  To observe the chronicity decompression effect of Astragalus Membranaceus(AM) and evaluate the effect on baroreflex sensitivity (BRS).
  
  
  METHODS
  Nineteen spontaneously hypertensive rats(SHR) were randomly divided into four groups. The AM groups were intraperitoneally administered with AM parenteral solution 0.9 mL, 1.2 mL and 1.8 mL respectively and the control group was not given AM for eight weeks. Then the change of blood pressure was observed successivly. After eight weeks, BRS were also determined. At last, the difference of blood pressure and BRS among the groups were compared.
  
  
  RESULTS
  Blood pressure in the control group became higher and higher frome the third week to the eighth week, but the other SHR admistered with AM showed no changein blood pressure level. We also found that the BRS in AM group was higher than that in the control group(P < 0.01).
  
  
  CONCLUSIONS
  AM can promote the BRS in SHR.
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310003, Zhejiang, China.
authors.forename: Zhi-kui
authors.initials: ZK
authors.lastname: Chen
authors.forename: Shen-jiang
authors.initials: SJ
authors.lastname: Hu
authors.forename: Xia
authors.initials: X
authors.lastname: Zhen
authors.forename: Guo-bing
authors.initials: GB
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
authors.forename: Yue-liang
authors.initials: YL
authors.lastname: Sheng
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D027885:Astragalus propinquus / Q000737:chemistry; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal