title: Association of HLA class I antigens and HLA class II alleles with vitiligo in a Turkish population.
abstract: As is the case with many other autoimmune diseases, there is an association between vitiligo and HLA complex. HLA subtypes vary with racial/ethnic background. The purpose of this study was to determine which HLA class I antigens and HLA class II alleles are associated with Turkish vitiligo patients. Forty-one patients with vitiligo and 61 healthy control subjects were typed for HLA class II alleles. Thirty-three out of 41 patients with vitiligo and 100 healthy transplant donors were typed for HLA class I antigens. HLA DNA typing was performed by polymerase chain reaction/sequence specific primer method for class II. HLA typing for class I was performed by serological method. The frequency of HLA DRB1*03 was 0.6340 in patients compared to 0.2950 in controls (P = 0.0014). The frequency of HLA DRB1*04 was found to be 0.6830 in patients compared to 0.2950 in controls (P = 0.00026). The allele HLA DRB1*07 was present in 0.390 of patients compared to 0.0820 of the controls (P = 0.0004). A preventive antigen for the manifestation of vitiligo has not been identified in this study. Our findings suggest that DRB1*03, DRB1*04 and DRB1*07 alleles are genetic markers for general susceptibility to vitiligo in a Turkish population.
authors.affiliation: Department of Dermatology, Gulhane Military Medical Academy School of Medicine, Etlik, Ankara, Turkey. btastan@gata.edu.tr
authors.forename: Halis Bülent
authors.initials: HB
authors.lastname: Taştan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akar
authors.forename: Funda Elif
authors.initials: FE
authors.lastname: Orkunoğlu
authors.forename: Ercan
authors.initials: E
authors.lastname: Arca
authors.forename: Ali
authors.initials: A
authors.lastname: Inal
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005802:Genes, MHC Class II / Q000235:genetics*; D006684:HLA-DR Antigens / Q000378:metabolism; D059811:HLA-DRB1 Chains; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014421:Turkey; D014820:Vitiligo / Q000235:genetics* / Q000276:immunology
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C456920:HLA-DRB1*07 antigen; D015395:Histocompatibility Antigens Class I