[Effects of yixintong on regulating cellular calcium channels].
OBJECTIVE
To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.


METHODS
The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.


RESULTS
Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.


CONCLUSIONS
Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.
Li
Si-cheng
SC
First Hosptal of Chongqing Medicine University, Chongqing 400016, China. lsicheng@yahoo.com
Huang
Hua
H
Zheng
Fei-ming
FM
Wen
De-liang
DL
Mo
Shang-wu
SW
D000818:Animals; D001011:Aorta / Q000166:cytology; D015220:Calcium Channels / Q000187:drug effects*; D027825:Crataegus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D015220:Calcium Channels; D004365:Drugs, Chinese Herbal; D005419:Flavonoids