title: Stroke-like pattern in DTI and MRS of childhood mitochondrial leukoencephalopathy.
abstract: In a 13-month-old boy with recurrent motor deterioration provoked by fever MRI and proton MRS detected a leukoencephalopathy with reduced cerebral metabolites and elevated lactate. At follow-up 6 and 16 months later these abnormalities improved gradually. Serial diffusion tensor imaging revealed a stroke-like pattern with an initial strong reduction of the apparent diffusion coefficient followed by elevated values 6 months later. The relative diffusion anisotropy remained reduced. Muscle biopsy confirmed a mitochondrial encephalomyopathy.
authors.affiliation: Department of Paediatrics and Neuropaediatrics, Georg August University, Göttingen, Germany. kbrock@med.uni-goettingen.de
authors.forename: K
authors.initials: K
authors.lastname: Brockmann
authors.forename: J
authors.initials: J
authors.lastname: Finsterbusch
authors.forename: U
authors.initials: U
authors.lastname: Schara
authors.forename: E
authors.initials: E
authors.lastname: Wilichowski
authors.forename: J
authors.initials: J
authors.lastname: Frahm
authors.forename: F
authors.initials: F
authors.lastname: Hanefeld
mesh_terms: D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017237:Mitochondrial Encephalomyopathies / Q000473:pathology*; D012075:Remission, Spontaneous