title: Potassium depletion in a healthy north-eastern Thai population: no association with tubulo-interstitial injury.
abstract: Potassium depletion prevails among the healthy population of north-east Thailand, as well as among patients with certain metabolic disorders such as upper urinary tract stones, the sudden unexplained death syndrome, distal renal tubular acidosis and hypokalaemic periodic paralysis. However, definite proof of the relationship of potassium depletion and these metabolic disorders is lacking. We prospectively studied muscle and kidney potassium content including renal tissue pathology in three groups of healthy adult Thai subjects who died of vehicular accidents. Group 1 (n = 24) were Bangkok city dwellers; groups 2 (n = 10) and 3 (n = 22) lived in north-eastern Thailand in the metropolitan area and in the villages, respectively. The muscle potassium content of group 1 (338.5 +/- 9.6 mEq/kg dry weight (DW)) were similar to group 2 (307.9 +/- 11.9 mEq/kg DW), but was greater than group 3 (295.4 +/- 9.1 mEq/kg DW; P < 0.01). The kidney potassium content of group 1 (208.6 +/- 7.8 mEq/kg DW) was significantly higher than group 3 (175.9 +/- 6.3 mEq/kg DW, P < 0.05). In group 3, the muscle potassium correlated linearly with the kidney potassium (r = 0.455, P = 0.33). None of the group 3 patients had renal histopathological change compatible with a diagnosis of focal or diffuse interstitial nephritis. This study confirms that potassium depletion is common among healthy rural dwellers in north-east Thailand. This deficit was probably chronic. However, there was minimal renal tubulo-interstitial change.
authors.affiliation: Department of Medicine, Rajvithi Hospital, Bangkok, Thailand. lelamali@hotmail.com
authors.forename: Kumtorn
authors.initials: K
authors.lastname: Lelamali
authors.forename: Wirut
authors.initials: W
authors.lastname: Khunkitti
authors.forename: Saowanee
authors.initials: S
authors.lastname: Yenrudi
authors.forename: Viratt
authors.initials: V
authors.lastname: Panichaphongse
authors.forename: Leang
authors.initials: L
authors.lastname: Huiprasert
authors.forename: Visith
authors.initials: V
authors.lastname: Sitprija
authors.forename: Kriang
authors.initials: K
authors.lastname: Tungsanga
mesh_terms: D000293:Adolescent; D000328:Adult; D002102:Cadaver; D005260:Female; D006801:Humans; D007668:Kidney / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000737:chemistry; D009395:Nephritis, Interstitial / Q000150:complications; D011188:Potassium / Q000032:analysis; D011191:Potassium Deficiency / Q000150:complications; D011446:Prospective Studies; D013785:Thailand
chemical_list: D011188:Potassium