title: Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells.
abstract: Novel 1,4,6-trisubstituted pyrazolo[3,4-d]pyrimidines are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (better than the reference compound) of Src phosphorylation of the breast cancer cells 8701-BC, known to overexpress Src. The ability of such compounds to significantly reduce 8701-BC cell proliferation suggests that this scaffold could be a promising lead for the development of antitumoral agents able to block Src phosphorylation of breast cancer cells.
authors.affiliation: Dipartimento di Fisiologia, Unità di Fisiologia Cellulare e Molecolare, Università degli Studi di Siena, Via Aldo Moro, I-53100 Siena, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Carraro
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pucci
authors.forename: Antonella
authors.initials: A
authors.lastname: Naldini
authors.forename: Silvia
authors.initials: S
authors.lastname: Schenone
authors.forename: Olga
authors.initials: O
authors.lastname: Bruno
authors.forename: Angelo
authors.initials: A
authors.lastname: Ranise
authors.forename: Francesco
authors.initials: F
authors.lastname: Bondavalli
authors.forename: Chiara
authors.initials: C
authors.lastname: Brullo
authors.forename: Paola
authors.initials: P
authors.lastname: Fossa
authors.forename: Giulia
authors.initials: G
authors.lastname: Menozzi
authors.forename: Luisa
authors.initials: L
authors.lastname: Mosti
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Manetti
authors.forename: Maurizio
authors.initials: M
authors.lastname: Botta
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001943:Breast Neoplasms; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015151:Immunoblotting; D010766:Phosphorylation; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D011720:Pyrazoles; D011743:Pyrimidines; D019061:src-Family Kinases