Polymorphic 33-bp repeats with promoter-like activity in synaptotagmin 11 gene.
In the immediate upstream region of the transcription initiation site of human synaptotagmin 11 gene, we found a tandem repeat of a 33-bp unit with a promoter-like activity. The tandem repeat is apparently polymorphic in the Japanese population as two DNA samples from 60 schizophrenia patients exhibited an increased number (three) of the unit. In a transfection assay using constructs with different numbers of repeats, the promoter-like activity was found to increase with the number of repeating unit.
Yokota
Hiroshi
H
Proteome Research Laboratory, Daiichi Pharmaceutical Co., 519 Shimo-Ishibashi, Ishibashi, Shimotsuga-gun, Tochigi 329-0512, Japan.
Tsujita
Takahiro
T
Okazaki
Yuji
Y
Kikuya
Eriko
E
Oishi
Michio
M
D000818:Animals; D001483:Base Sequence; D019556:COS Cells; D002135:Calcium-Binding Proteins / Q000235:genetics*; D006224:Cricetinae; D004742:Enhancer Elements, Genetic; D017930:Genes, Reporter; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic; D011485:Protein Binding / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*; D016329:Sp1 Transcription Factor / Q000235:genetics; D050857:Synaptotagmins; D020080:Tandem Repeat Sequences / Q000235:genetics*; D024363:Transcription Initiation Site; D014158:Transcription, Genetic
D002135:Calcium-Binding Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D016329:Sp1 Transcription Factor; D050857:Synaptotagmins