[The neurotropic activity of food-derived opioid peptides beta-casomorphins].
In the review the history of food-derived opioid peptides beta-casomorphins (beta-cas) discovery is given. The beta-cas formation in gastrointestinal tract during the beta-casein degradation and the following penetration into the blood are described, in the first place in newborn mammals. The attention is focused on neurotropic activity of beta-cas: their influence on the pain sensitivity, locomotion, anxiety and learning of experimental animals. The beta-cas ability to change the characteristics of mother-infant interaction is specially analysed. The necessity to take into consideration of beta-cas physiological effects on nursing dams and newborns behaviour is noted.
Dubynin
V A
VA
Lomonosov State University, Faculty of Biology, Department of Human and Animal Physiology.
Ivleva
Iu A
IuA
Kamenskiĭ
A A
AA
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000819:Animal Communication; D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects; D002364:Caseins / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D041981:Gastrointestinal Tract / Q000378:metabolism; D007858:Learning / Q000187:drug effects; D008124:Locomotion / Q000187:drug effects; D008322:Mammals; D009292:Narcotic Antagonists; D010146:Pain; D011957:Receptors, Opioid / Q000819:agonists* / Q000502:physiology
D000701:Analgesics, Opioid; D002364:Caseins; D004723:Endorphins; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; C021968:beta-casomorphins