Small molecule inhibition of hypoxia inducible factor-1alpha: a viable therapeutic approach?
Tew
Kenneth D
KD
Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. KD_Tew@fccc.edu
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry*
D000970:Antineoplastic Agents; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D014157:Transcription Factors