Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa.
[structure: see text] Four new dolabellane-type diterpene alkaloids, nigellamines A(1) (1), A(2) (2), B(1) (3), and B(2) (4), were isolated from the seeds of Nigella sativa. Their absolute stereostructures were determined on the basis of chemical and physicochemical evidence. Nigellamines A(1) (1), B(1) (3), and B(2) (4) were found to show potent lipid metabolism promoting activity in primary cultured mouse hepatocytes, and their activities were equivalent to that of a PPAR-alpha agonist, clofibrate.
Morikawa
Toshio
T
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan. shoyaku@mb.kuoto-phu.ac.jp
Xu
Fengming
F
Kashima
Yousuke
Y
Matsuda
Hisashi
H
Ninomiya
Kiyofumi
K
Yoshikawa
Masayuki
M
D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry*; D022781:Hepatocytes; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D031881:Nigella sativa / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism; D010946:Plants, Medicinal; D012639:Seeds / Q000737:chemistry; D014280:Triglycerides / Q000037:antagonists & inhibitors
D000470:Alkaloids; D004224:Diterpenes; D010936:Plant Extracts; D014280:Triglycerides; C115566:dolabellane