Effect of agmatine on the time course of brain inflammatory cytokines after injury in rat pups.
Pro-inflammatory cytokines play an important role in brain injury. Agmatine reduces brain injury. Does agmatine act by reducing cytokines? Seven-day-old rat pups had the right carotid artery ligated and then were subjected to 2.5 hours of 8% oxygen. Agmatine (100 mg/kg) or vehicle was administered at 5 minutes after reoxygenation. Cytokines were measured in the cortex by enzyme-linked immunosorbent assay. Interleukin (IL)-6, IL-1b, and tumor necrosis factor-alpha (TNF-alpha) were significantly increased after reoxygenation. Agmatine had no effect.
Feng
Yangzheng
Y
Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
LeBlanc
Michael H
MH
D000376:Agmatine / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D002545:Brain Ischemia / Q000378:metabolism; D002534:Hypoxia, Brain / Q000378:metabolism; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000376:Agmatine