Reed-Sternberg-like cells in T-cell rich B-cell lymphoma: a diagnostic dilemma.
T-cell-rich B-cell lymphoma (TCRBCL) is a recently described variant of diffuse Non-Hodgkin's lymphoma (NHL) which requires immunohistochemical analysis for its recognition. Striking similarities exist between TCRBCL and lymphocyte predominant Hodgkin's Disease (LPHD) due to the presence of Reed-Sternberg (R-S) like cells. Hence, the need for distinction between the two is of utmost importance from a prognostic and therapeutic stand point. The present study describes a case of TCRBCL, misdiagnosed as Hodgkin's Disease (HD) on fine needle aspiration (FNA) cytology. However, immunostaining of paraffin embedded sections corrected the cytological diagnosis.
Shahabuddin
M D
MD
Sikkim Manipal Medical College, Gangtok, Sikkim. shahab_2003@yahoo.com
Raghuveer
C V
CV
D000328:Adult; D001707:Biopsy, Needle; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008297:Male; D016539:Reed-Sternberg Cells / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*