title: A receptor for green tea polyphenol EGCG.
abstract: The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka, 812-8581, Japan. tatibana@agr.kyushu-u.ac.jp
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tachibana
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Koga
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujimura
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
mesh_terms: D016588:Anticarcinogenic Agents / Q000493:pharmacokinetics; D000975:Antioxidants / Q000493:pharmacokinetics; D001665:Binding Sites; D002392:Catechin / Q000031:analogs & derivatives* / Q000378:metabolism*; D007700:Kinetics; D017474:Receptors, Laminin / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D016588:Anticarcinogenic Agents; D000975:Antioxidants; D017474:Receptors, Laminin; D002392:Catechin; C045651:epigallocatechin gallate