title: Side effects of the Yuzpe regimen of emergency contraception and two modifications.
abstract: We investigated side effects after the standard Yuzpe regimen or two modifications: substituting norethindrone as the progestin or eliminating the second dose. We also examined the impact of taking either dose with food. Nearly two thirds of women reported at least one side effect, the majority of which were mild or moderate. Women in our study experienced more side effects after the second dose than after the first. Taking the first dose within 1 h of a meal or snack was associated with increased nausea and vomiting; taking the second dose within 1 h of a meal or snack was associated with decreased nausea and vomiting. A targeted approach to prophylactic antiemetic use could reduce the number of women given these drugs, and the number who experience unnecessary side effects. The impact of counseling on side effects should be further evaluated.
authors.affiliation: School of Public Health, University of Michigan, Ann Arbor, MI, USA. tshochet@umich.edu
authors.forename: Tara
authors.initials: T
authors.lastname: Shochet
authors.forename: Kelly
authors.initials: K
authors.lastname: Blanchard
authors.forename: Helen
authors.initials: H
authors.lastname: King
authors.forename: Bridget
authors.initials: B
authors.lastname: Henchcliffe
authors.forename: Janice
authors.initials: J
authors.lastname: Hunt
authors.forename: Chris
authors.initials: C
authors.lastname: McCaig
authors.forename: Kate
authors.initials: K
authors.lastname: Weaver
authors.forename: Alex
authors.initials: A
authors.lastname: Stirling
authors.forename: Anna
authors.initials: A
authors.lastname: Glasier
authors.forename: Anne
authors.initials: A
authors.lastname: Webb
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ellertson
mesh_terms: D002626:Chemistry, Pharmaceutical; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage* / Q000009:adverse effects; D003281:Contraceptives, Postcoital / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D009325:Nausea / Q000139:chemically induced; D009640:Norethindrone / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic
chemical_list: D003277:Contraceptives, Oral, Combined; D003281:Contraceptives, Postcoital; D009640:Norethindrone