title: Are men at greater risk for Parkinson's disease than women?
abstract: Parkinson's disease seems to occur more commonly in men than women based primarily on studies of death rates and prevalence. In recent years, several population based incidence studies of Parkinson's disease that included sex data have been conducted in a variety of populations around the world. To investigate whether these incidence studies suggest an increased risk of Parkinson's disease in men, a meta-analysis was performed of the differences in incidence of Parkinson's disease between men and women reported in seven studies that met the inclusion criteria. A significantly higher incidence rate of Parkinson's disease was found among men with the relative risk being 1.5 times greater in men than women. Possible reasons for this increased risk of Parkinson's disease in men are toxicant exposure, head trauma, neuroprotection by oestrogen, mitochondrial dysfunction, or X linkage of genetic risk factors.
authors.affiliation: Department of Neurology, Box 800394, University Health System, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. gfw4b@virginia.edu
authors.forename: G F
authors.initials: GF
authors.lastname: Wooten
authors.forename: L J
authors.initials: LJ
authors.lastname: Currie
authors.forename: V E
authors.initials: VE
authors.lastname: Bovbjerg
authors.forename: J K
authors.initials: JK
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Patrie
mesh_terms: D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D010300:Parkinson Disease / Q000453:epidemiology* / Q000209:etiology; D012306:Risk; D012737:Sex Factors