title: Plasma cell differentiation and multiple myeloma.
abstract: Microarray analyses and gene targeting have recently enhanced the understanding of factors involved in normal plasma cells and multiple myeloma. Plasma cells develop from marginal zone or germinal center B cells following stimulation by antigen, microbial products, TNF family signals and cytokines. Transcription factors, B-lymphocyte-induced maturation protein 1 (Blimp-1) and X-box binding protein 1 (XBP-1) are required for plasma cell development. They regulate sets of genes that induce immunoglobulin secretion, halt proliferation and block alternative B-cell fates. In multiple myeloma, transforming events lead to proliferation and survival, but programs for plasma cell differentiation and the inhibition of B-cell genes appear to be largely intact.
authors.affiliation: Integrated Program in Cellular, Molecular and Biophysical Studies, Columbia University, College of Physicians and Surgeons, 1204 HHSC, 701 West 168th Street, New York, NY 10032, USA.
authors.forename: Miriam
authors.initials: M
authors.lastname: Shapiro-Shelef
authors.forename: Kathryn
authors.initials: K
authors.lastname: Calame
mesh_terms: D002454:Cell Differentiation; D005786:Gene Expression Regulation; D009101:Multiple Myeloma / Q000276:immunology* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D011947:Receptors, Antigen, B-Cell; D014157:Transcription Factors