Novel herpesviruses of Suidae: indicators for a second genogroup of artiodactyl gammaherpesviruses.
Five novel herpesviruses were identified in suid species from Africa (common warthog, Phacochoerus africanus) and South-East Asia (bearded pig, Sus barbatus; babirusa, Babyrousa babyrussa) by detection and analysis of their DNA polymerase genes. Three of the novel species, P. africanus cytomegalovirus 1, P. africanus lymphotropic herpesvirus 1 (PafrLHV-1) and S. barbatus lymphotropic herpesvirus 1 (SbarLHV-1), were closely related to known beta- (porcine cytomegalovirus) and gammaherpesviruses [porcine lymphotropic herpesvirus (PLHV) 1 and 3] of domestic pigs. In contrast, two novel species, S. barbatus rhadinovirus 1 (SbarRHV-1) and Babyrousa babyrussa rhadinovirus 1 (BbabRHV-1), were more closely related to a ruminant gammaherpesvirus, bovine herpesvirus 4 (BoHV-4), than to the porcine gammaherpesviruses PLHV-1, -2, -3, PafrLHV-1 and SbarLHV-1. SbarRHV-1, BbabRHV-1 and BoHV-4 were therefore tentatively assigned to a novel genogroup of artiodactyl gammaherpesviruses. This latter genogroup may also contain an as yet undiscovered gammaherpesvirus of domestic pigs, thereby adding a concern to their use in xenotransplantation.
Ehlers
Bernhard
B
P11/Neuartige Viren, Robert Koch-Institut, Nordufer 20, D-13353 Berlin, Germany.
Lowden
Stewart
S
Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK.
D000595:Amino Acid Sequence; D000818:Animals; D001188:Artiodactyla / Q000821:virology*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D018142:Gammaherpesvirinae / Q000145:classification* / Q000201:enzymology / Q000235:genetics*; D006566:Herpesviridae Infections / Q000635:transmission / Q000662:veterinary; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D034421:Sus scrofa / Q000821:virology; D013552:Swine / Q000821:virology*; D014183:Transplantation, Heterologous / Q000009:adverse effects
D004259:DNA-Directed DNA Polymerase