[Liquid phase method of synthesizing polyamides binding DNA using oligocarboxamide blocks].
A method was developed for the synthesis of sequence-specific polyamides on the basis of 4-amino-1-methylpyrrole-2-carboxylic acid, 4-amino-1-methylimidazole-2-carboxylic acid, beta-alanine, and gamma-aminobutyric acid. Dimeric and trimeric oligocarboxamides were used as building blocks. Our synthetic scheme was applied for the synthesis of DNA minor groove binders containing up to twelve carboxamide units. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
Sniiakov
A N
AN
Feshchenko
M V
MV
Riabinin
V A
VA
D000577:Amides / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009757:Nylons / Q000737:chemistry*
D000577:Amides; D009757:Nylons; D004247:DNA