T-cell anergy.
Self-reactive T cells that escape negative selection in the thymus must be inactivated in the periphery. Anergy constitutes one means of imposing peripheral tolerance. Anergic T cells are functionally inactivated and unable to initiate a productive response even when antigen is encountered in the presence of full co-stimulation. Recent studies have provided new insights into the mechanisms responsible for the induction and maintenance of T-cell anergy. These studies have helped clarify the nature of the signals that induce tolerance, the cells able to deliver them and the molecular processes that underlie the unresponsive state.
Macián
Fernando
F
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Im
Sin-Hyeog
SH
García-Cózar
Francisco J
FJ
Rao
Anjana
A
D000818:Animals; D017635:Clonal Anergy; D003713:Dendritic Cells / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D017634:Self Tolerance; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D011948:Receptors, Antigen, T-Cell