title: Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration.
abstract: In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
authors.affiliation: Institute of Anatomy and Cell Biology, Università Cattolica del S. Cuore, Largo Francesco Vito 1, I-00168 Rome, Italy.
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Geloso
authors.forename: Valentina
authors.initials: V
authors.lastname: Corvino
authors.forename: Valentina
authors.initials: V
authors.lastname: Cavallo
authors.forename: Amelia
authors.initials: A
authors.lastname: Toesca
authors.forename: Enrico
authors.initials: E
authors.lastname: Guadagni
authors.forename: Roberto
authors.initials: R
authors.lastname: Passalacqua
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Michetti
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007381:Intermediate Filament Proteins / Q000096:biosynthesis* / Q000235:genetics; D009410:Nerve Degeneration / Q000139:chemically induced / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D064231:Nestin; D051381:Rats; D017208:Rats, Wistar; D014298:Trimethyltin Compounds / Q000633:toxicity*
chemical_list: D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin; D014298:Trimethyltin Compounds; C046488:trimethyltin