title: Neuroblastoma: evolving therapies for a disease with many faces.
abstract: Neuroblastoma is the most common extra-cranial solid tumor in children and has a heterogeneous clinical presentation and course. Clinical and biologic features of this disease have been used to develop risk-based therapy. Patients with low-risk disease can be treated with surgery alone. Patients with intermediate-risk features have an excellent prognosis after treatment with surgery and a relatively short course of standard dose chemotherapy. Unfortunately, most children with neuroblastoma present with advanced disease. More than 60% of patients with high-risk features will succumb to their disease despite intensive therapy including a myeloablative consolidation. Research efforts to understand the biologic basis of neuroblastoma and to identify new, more effective therapies are essential to improve the outcome for these children.
authors.affiliation: Division of Pediatric Hematology/Oncology, University of California, San Francisco 94143-0106, USA.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Goldsby
authors.forename: Katherine K
authors.initials: KK
authors.lastname: Matthay
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D009447:Neuroblastoma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor