Combined association between IFN-gamma 3,3 homozygosity and DRB1*03 in Löfgren's syndrome patients.
In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively were detected in sarcoidosis patients. IFN-gamma 3,3 homozygosity was found to constitute a risk factor associating with LS manifestation (0.50 versus 0.19, OD = 4.18, P = 0.014). As expected, DRB1*03 prevailed in LS cases (9/14 versus 7/29, P = 0.014 LS versus non-LS cases and 9/14 versus 35/162, OD = 6.20, P = 0.001, LS patients versus controls). However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).
Wysoczanska
Barbara
B
L. Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolf Weigl 12, 53-114 Wroclaw.
Bogunia-Kubik
Katarzyna
K
Suchnicki
Krzysztof
K
Mlynarczewska
Anna
A
Lange
Andrzej
A
D000328:Adult; D000483:Alleles; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006720:Homozygote; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D007438:Introns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D013577:Syndrome; D020080:Tandem Repeat Sequences / Q000235:genetics
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D007371:Interferon-gamma