Insulin-like growth factor binding protein 1 (IGFBP-1) in vaginal fluid in pregnancy.
OBJECTIVE
To examine vaginal insulin-like growth factor binding protein 1 (IGFBP-1) as a marker of preterm delivery, amniotic fluid leakage or vaginal infection.


METHODS
The material consisted of a nested case-control study (67 with idiopathic preterm delivery and 406 randomly selected women with term deliveries) from a prospective cohort of 2,846 women.


RESULTS
Vaginal npIGFBP-1 was weakly associated with preterm delivery. Elevated npIGFBP-1 gave an increased risk of preterm delivery (OR 2.8 [1.4-6. 7]). Elevated IGFBP-1 provided a sensitivity of 13% at a false-positive rate of 4.4% in a low-risk population. When adjusting for other covariates associated with preterm delivery the association between npIGFBP-1 and preterm delivery disappeared; there was an interaction between alcohol consumption and npIGFBP-1.


CONCLUSIONS
The current study found vaginal npIGFBP-1 to be weakly associated with gestational age at delivery. However, in this study the association may potentially be explained by alcohol consumption.
Vogel
Ida
I
Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark. idavogel@dadlnet.dk
Grønbaek
Henning
H
Thorsen
Poul
P
Flyvbjerg
Allan
A
D000653:Amniotic Fluid / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D007752:Obstetric Labor, Premature / Q000378:metabolism; D010766:Phosphorylation; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000378:metabolism; D011257:Pregnancy Proteins / Q000378:metabolism*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D014621:Vagina / Q000378:metabolism*
D018970:Insulin-Like Growth Factor Binding Protein 1; D011257:Pregnancy Proteins