Concurrent infantile hemangioendothelioma and mesenchymal hamartoma in a developmentally arrested liver of an infant requiring hepatic transplantation.
A newborn female underwent a surgical resection for a hepatic mass discovered prenatally by ultrasonography, and diagnosed pathologically as a mesenchymal hamartoma. Within 4 months after surgery, multiple cutaneous hemangiomas developed and a multinodular mass was detected in the liver. A liver biopsy showed an infantile hemangioendothelioma with type I features. An orthotopic liver transplant was performed due to the extensive nature of the hepatic involvement and progressive respiratory compromise. Virtually the entire liver was involved by a large infantile hemangioendothelioma. A multicystic mesenchymal hamartoma was also found on the left side. In addition, the uninvolved hepatic parenchyma had features recapitulating the fetal liver. This simultaneous involvement of the liver by a mesenchymal hamartoma and infantile hemangioendothelioma is unique. A review of the literature revealed only one incompletely characterized case with similar findings.
Bejarano
Pablo A
PA
Department of Pathology, University of Miami School of Medicine, Jackson Memorial Hospital, 1611 NW 12th Avenue, Holtz Center-Room 2042, Miami, FL 33136, USA. pbejaran@med.miami.edu
Serrano
Maria F
MF
Casillas
Javier
J
Dehner
Louis P
LP
Kato
Tomoaki
T
Mitral
Naveen
N
Rodriguez
Maria M
MM
Tzakis
Andreas
A
D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000151:congenital / Q000473:pathology; D006390:Hemangioendothelioma / Q000150:complications* / Q000151:congenital / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D008648:Mesoderm / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000151:congenital / Q000473:pathology*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal