Facile protocol for the highly regioselective and stereodivergent synthesis of substituted bishomoallylic alcohols from esters.
Regio- and diastereoselective preparation of bishomoallylic alcohols was realized by a facile four-step protocol including alpha,alpha'-selective zinc-mediated bispropargylation of unactivated esters and stereoselective reduction of the resulting bishomopropargylic alcohols.
Oestreich
Martin
M
Institut für Organische Chemie und Biochemie, Albert-Ludwigs-Universität, Albertstrasse 21, D-79104 Freiburg im Breisgau, Germany. martin.oestreich@orgmail.chemie.uni-freiburg.de
Sempere-Culler
Fernando
F