title: C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study.
abstract: OBJECTIVE
  To determine the impact of moderate alcohol consumption on long term prognosis after successful coronary stenting, and whether it could be related to preprocedural plasma C reactive protein (CRP).
  
  
  METHODS
  Part of the prospectively designed GENERATION study which investigated the impact of several biochemical factors, including plasma CRP, on long term prognosis after coronary stenting.
  
  
  METHODS
  Tertiary referral centre.
  
  
  METHODS
  483 consecutive patients with stable or unstable coronary artery disease who underwent successful coronary stenting and were followed for up to four years. Information about alcohol consumption was collected prospectively.
  
  
  METHODS
  Successful coronary stenting.
  
  
  METHODS
  The incidence of the composite end point of readmission to hospital for unstable angina, non-fatal myocardial infarction, or cardiac death, whichever occurred first.
  
  
  RESULTS
  By the end of follow up the incidence of the composite end point was 22.8%. Patients with a baseline plasma CRP concentration of < 0.68 mg/dl (defined by ROC analysis) did not show any difference in the composite end point (p = 0.9) or its components, regardless of the amount of alcohol consumed during follow up. However, among patients with plasma CRP concentration of > or = 0.68 mg/dl, those who drank moderately had a lower incidence of the composite end point (p < 0.001) or its components.
  
  
  CONCLUSIONS
  Moderate alcohol consumption may have a beneficial impact on the long term prognosis following successful coronary stenting. The extent of this effect is positively related to preprocedural inflammatory status. An anti-inflammatory action of moderate alcohol consumption cannot be excluded.
authors.affiliation: Department of Cardiology, Tzanio Hospital, Piraeus, Greece. zairis@hellasnet.gr
authors.forename: M N
authors.initials: MN
authors.lastname: Zairis
authors.forename: J A
authors.initials: JA
authors.lastname: Ambrose
authors.forename: A G
authors.initials: AG
authors.lastname: Lyras
authors.forename: M A
authors.initials: MA
authors.lastname: Thoma
authors.forename: P K
authors.initials: PK
authors.lastname: Psarogianni
authors.forename: P G
authors.initials: PG
authors.lastname: Psaltiras
authors.forename: A D
authors.initials: AD
authors.lastname: Kardoulas
authors.forename: G P
authors.initials: GP
authors.lastname: Bibis
authors.forename: E G
authors.initials: EG
authors.lastname: Pissimissis
authors.forename: P C
authors.initials: PC
authors.lastname: Batika
authors.forename: M C
authors.initials: MC
authors.lastname: DeVoe
authors.forename: A A
authors.initials: AA
authors.lastname: Prekates
authors.forename: S G
authors.initials: SG
authors.lastname: Foussas
mesh_terms: D000428:Alcohol Drinking / Q000097:blood / Q000401:mortality*; D000789:Angina, Unstable / Q000097:blood / Q000401:mortality / Q000601:surgery; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D015607:Stents; D016019:Survival Analysis
chemical_list: D002097:C-Reactive Protein