Kigamicins, novel antitumor antibiotics. II. Structure determination.
Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.
Kunimoto
Setsuko
S
Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. kunimotos@bikaken.or.jp
Someno
Tetsuya
T
Yamazaki
Yohko
Y
Lu
Jie
J
Esumi
Hiroyasu
H
Naganawa
Hiroshi
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000903:Antibiotics, Antineoplastic; D010080:Oxazoles; C484116:kigamicin A; C484115:kigamicin B; C484114:kigamicin C; C484110:kigamicin D; C484112:kigamicin E; D004317:Doxorubicin