title: Heart rate variability as an indicator of outcome in congenital diaphragmatic hernia with and without ECMO support.
abstract: OBJECTIVE
  To examine differences in the spectral power content in neonates diagnosed with congenital diaphragmatic hernia (CDH) who survive or succumb.
  
  
  METHODS
  A case-series study design evaluated four neonates diagnosed with CDH, two of which were supported by extracorporeal membrane oxygenation (ECMO). The electrocardiogram signal was digitized at 1000 Hz and the Lomb periodogram was computed for the series of interbeat intervals.
  
  
  RESULTS
  Neonates with CDH who survived had log total power values greater than 2. Those with CDH who did not survive had log total power less than 2, but generally exceeded 3 while they were supported by ECMO.
  
  
  CONCLUSIONS
  Neonates who consistently displayed increasing total spectral energies had a better outcome than those whose spectral energies were low. Subjects who succumbed expressed the lowest values, suggesting that a frequency-based evaluation of HRV may be a sensitive prognosticator of outcome that requires further investigation.
authors.affiliation: University of Texas Health Science Center at Houston, School of Nursing, Systems and Technology, Houston, TX 77030, USA.
authors.forename: M Terese
authors.initials: MT
authors.lastname: Verklan
authors.forename: Nikhil S
authors.initials: NS
authors.lastname: Padhye
mesh_terms: D016022:Case-Control Studies; D004562:Electrocardiography; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006548:Hernia, Diaphragmatic / Q000401:mortality / Q000628:therapy; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012815:Signal Processing, Computer-Assisted