Lethal subarachnoid bleeding under immunosuppressive therapy due to mycotic arteritis.
A subarachnoid haemorrhage (SAH) occurred 67 days after cardiac transplantation in a 10-year-old girl with consecutive immunocompromising therapy. Neither digital subtraction angiography (DSA) nor computed tomographic angiography showed signs of intracranial vascular malformations. One month before the lethal SAH occurred, she had developed arterial hypertension and attacks of severe headache with cerebrospinal fluid (CSF) pleocytosis while CT scans showed an infarct of the left thalamus. Pathologic findings established the rare diagnosis of SAH due to aspergillosis-related mycotic arteritis. Imaging characteristics are presented.
Weigel
Stefanie
S
Department of Clinical Radiology, University Hospital of Muenster, Albert-Schweitzer-Strasse 33, 48149 Münster, Germany. weigels@uni-muenster.de
Kloska
Stephan
S
Kehl
Hans Gerd
HG
Freund
Michael
M
D015901:Angiography, Digital Subtraction / Q000379:methods*; D001167:Arteritis / Q000000981:diagnostic imaging* / Q000209:etiology; D001228:Aspergillosis / Q000175:diagnosis; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000601:surgery; D002648:Child; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000175:diagnosis; D016027:Heart Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D009894:Opportunistic Infections / Q000175:diagnosis; D012680:Sensitivity and Specificity; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging* / Q000209:etiology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014181:Transplantation Immunology
D007166:Immunosuppressive Agents