title: Localization of monoamine oxidase A and B and semicarbazide-sensitive amine oxidase in human peripheral tissues.
abstract: Monoamine oxidase (MAO) A and B and semicarbazide-sensitive amine oxidase (SSAO) localizations in peripheral human tissues were compared by immunohistochemistry. The primary antibodies used were mouse monoclonal anti-human MAO-A (6G11/E1) and anti-human MAO-B (3F12/G10/2E3) and a rabbit polyclonal anti-bovine SSAO antibody. Immunoreactivities of the samples, obtained from 6 routine autopsy cases, showed different distributions in the tissues studied (heart, lung, duodenum, liver, pancreas, spleen, thyroid gland, adrenal gland and kidney). The relative MAO-A, MAO-B and SSAO distributions indicated a widespread distribution of these enzymes in the human body that is characterized by a matching cellular pattern in only few tissues. These differences suggest that each amine oxidase may play a specific function in, at least some, peripheral tissues.
authors.affiliation: Unitat de Bioquímica, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, C/Casanova 143, E-08036 Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Ramonet
authors.forename: M
authors.initials: M
authors.lastname: Rodríguez
authors.forename: J
authors.initials: J
authors.lastname: Saura
authors.forename: J M
authors.initials: JM
authors.lastname: Lizcano
authors.forename: M
authors.initials: M
authors.lastname: Romera
authors.forename: M
authors.initials: M
authors.lastname: Unzeta
authors.forename: C
authors.initials: C
authors.lastname: Finch
authors.forename: E
authors.initials: E
authors.lastname: Billett
authors.forename: N
authors.initials: N
authors.lastname: Mahy