Trichinella spiralis: activity of the cerebral pyruvate recycling pathway of the host (mouse) in hypoglycemia induced by the infection.
The activity of the cerebral pyruvate recycling pathway and energy metabolism in mice infected with Trichinella spiralis were investigated using (13)C-NMR and in vivo (31)P-NMR spectroscopy, respectively. The (13)C-NMR analysis, using [1,2-(13)C(2)] acetate as a substrate, of whole-brain extracts demonstrated that activity of the pathway increased when T. spiralis infection induced hypoglycemia in the host. The in vivo (31)P-NMR observation showed that the cerebral ATP in normal level sustained throughout this experiment. These findings indicate that the pyruvate recycling pathway plays a role in the energy supply to the host in hypoglycemia induced by T. spiralis infection.
Nishina
Masami
M
Department of Immunology, Saitama Medical School, 38 Morohongo Moroyama Irumagun, Saitama 350-0495, Japan. masa247@saitama-med.ac.jp
Suzuki
Masahiko
M
Matsushita
Kazuhiro
K
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D004734:Energy Metabolism; D006790:Host-Parasite Interactions; D007003:Hypoglycemia / Q000378:metabolism* / Q000469:parasitology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D010759:Phosphorus Isotopes; D019289:Pyruvic Acid / Q000378:metabolism*; D017160:Trichinella spiralis / Q000502:physiology*; D014235:Trichinellosis / Q000150:complications / Q000378:metabolism*
D002247:Carbon Isotopes; D010759:Phosphorus Isotopes; D019289:Pyruvic Acid