title: Metallophosphites as umpolung catalysts: the enantioselective cross silyl benzoin reaction.
abstract: Carbonyl polarity reversal (umpolung) has been realized employing metallophosphites as catalysts. As a result, nonenzymatic asymmetric cross silyl benzoin reactions have been achieved, giving optically active silyl ether-protected benzoin adducts. The reaction is general with respect to aryl, alkyl, and heterocyclic substrates with good to excellent yields and good to excellent enantioselectivities.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Linghu
authors.forename: Justin R
authors.initials: JR
authors.lastname: Potnick
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Johnson