title: [The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats].
abstract: OBJECTIVE
  To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action.
  
  
  METHODS
  Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI).
  
  
  RESULTS
  Seed oil of Hippophae rhamnides 0.7 and 0.35 g.kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats.
  
  
  CONCLUSIONS
  These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.
authors.affiliation: Lanzhou Medical College, Lanzhou 730000, Ganshu, China. litjian@public.lz.gs.cn
authors.forename: Ti-juan
authors.initials: TJ
authors.lastname: Cheng
authors.forename: Yu-bin
authors.initials: YB
authors.lastname: Wang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Gao
authors.forename: Yi-fang
authors.initials: YF
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D031281:Hippophae / Q000737:chemistry; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D010938:Plant Oils