Antimycobacterial compounds. New pyrrole derivatives of BM212.
We have identified BM212 as a lead compound among a series of pyrrole derivatives with good in vitro activity against mycobacteria and candidae. First studies led us to synthesize some pyrrole compounds in which the thiomorpholine fragment was present. Some compounds revealed very active and these findings prompted us to prepare new pyrrole derivatives 2-15 in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria.
Biava
Mariangela
M
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università 'La Sapienza', P le A Moro 5, 00185 Rome, Italy. mariangela.biava@uniroma1.it
Porretta
Giulio Cesare
GC
Deidda
Delia
D
Pompei
Raffaello
R
Tafi
Andrea
A
Manetti
Fabrizio
F
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000995:Antitubercular Agents; D010879:Piperazines; D011758:Pyrroles; C115651:BM 212