Organic chemistry in drug discovery.
The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions.
MacCoss
Malcolm
M
Department of Basic Chemistry, Merck Research Laboratories, 126 East Lincoln Avenue, Rahway, NJ 07065, USA. malcolm_maccoss@merck.com
Baillie
Thomas A
TA
D000818:Animals; D055598:Chemical Phenomena; D002625:Chemistry, Organic; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D004345:Drug Industry; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D055601:Organic Chemistry Phenomena; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism; D010599:Pharmacokinetics; D010600:Pharmacology; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical
D004364:Pharmaceutical Preparations