Antigenic variation in African trypanosomes: monitoring progress.
Antigenic variation is central to the success of African trypanosomes and other eukaryotic, bacterial and viral pathogens. Our understanding of the control and execution of this immune evasion strategy in trypanosomes is incomplete, despite the molecular basis of antigenic variation being first described over 20 years ago. Recent research progress in this field is highlighted here and some of the unresolved questions raised.
McCulloch
Richard
R
Wellcome Centre for Molecular Parasitology, University of Glasgow, Anderson College, 56 Dumbarton Road, Glasgow, G11 6NU, UK. rmc9z@udcf.gla.ac.uk
D000818:Animals; D000940:Antigenic Variation / Q000235:genetics / Q000276:immunology*; D014644:Genetic Variation / Q000276:immunology; D005960:Glucosides / Q000235:genetics / Q000276:immunology; D014158:Transcription, Genetic / Q000235:genetics / Q000276:immunology; D014346:Trypanosoma brucei brucei / Q000235:genetics / Q000276:immunology*; D014353:Trypanosomiasis, African / Q000276:immunology* / Q000469:parasitology; D014498:Uracil / Q000031:analogs & derivatives* / Q000276:immunology; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000235:genetics / Q000276:immunology
D005960:Glucosides; D014643:Variant Surface Glycoproteins, Trypanosoma; C084880:5-((glucopyranosyloxy)methyl)uracil; D014498:Uracil