Fluvastatin increases LDL particle size and reduces oxidative stress in patients with hyperlipidemia.
The effects of fluvastatin on levels of urinary 8-iso-prostaglandin F2alpha (iPF2alphaIII), a marker of oxidative stress, and low-density lipoprotein (LDL) particle size in serum were investigated in patients with hypercholesterolemia. After 6 months of fluvastatin therapy, levels of urinary iPF2alphaIII decreased from 1720.1 +/- 392.0 to 539.6 +/- 75.5 pg/mg (p < 0.01), and LDL particle size increased from 24.3 +/- 0.3 to 26.5 +/- 0.2 nm (p < 0.001). These changes from the treatment of fluvastatin were not correlated with those of the serum LDL cholesterol (LDL-C) levels. The results imply that fluvastatin, with its unique antioxidant property among statins, reduces oxidative stress and increases LDL particle size simultaneously in hyperlipidemic patients.
Yoshino
Gen
G
Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan. yoshino@med.toho-u.ac.jp
Hirano
Tsutomu
T
Kazumi
Tsutomu
T
Takemoto
Masayo
M
Ohashi
Noriko
N
D000368:Aged; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D005260:Female; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000097:blood* / Q000188:drug therapy* / Q000652:urine; D007211:Indoles / Q000627:therapeutic use*; D008077:Lipoproteins, LDL / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D010316:Particle Size
D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D008077:Lipoproteins, LDL; C075750:8-epi-prostaglandin F2alpha; D000077340:Fluvastatin; D015237:Dinoprost