Association of progesterone receptor polymorphism with recurrent abortions.
OBJECTIVE
The current study sought for polymorphisms within the progesterone receptor (PR) gene. Allele and genotype frequencies of patients with repeated abortions were compared to a control group.


METHODS
All exons of the PR of 42 women with repeated abortions and 40 controls were screened for single nucleotide polymorphisms (SNP). Determination of the DNA-sequences was performed.


RESULTS
Three SNPs were detected (exon 1: G1031C Ser344Thr; exon 4: G1978T Leu660Val, exon 5: C2310T His770His). These SNPs are linked. The more frequent wildtype (*1) allele and the rarer (*2) allele were found in the control group and in the study group at different frequencies (control group: *1/*1: 78%, *1/*2: 22%, *2/*2: 0%; patient group: *1/*1: 50%, *1/*2: 43%, *2/*2: 7%). The genotypes distributions differed significantly from each other (P=0.019, chi2=7.879).


CONCLUSIONS
The data suggest that the rarer PR allele may be associated with an increased likelihood of repeated miscarriages contributing to its multi-factorial causes.
Schweikert
Andreas
A
Division of Gynecological Endocrinology & Reproductive Medicine, Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, Universitätsstrasse 21-23, 91054 Erlangen, Germany.
Rau
Thomas
T
Berkholz
Alexander
A
Allera
Axel
A
Daufeldt
Sabine
S
Wildt
Ludwig
L
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011980:Receptors, Progesterone / Q000235:genetics*
D017931:DNA Primers; D011980:Receptors, Progesterone