title: Analgesic studies on total alkaloids and alcohol extracts of Eclipta alba (Linn.) Hassk.
abstract: A variety of analgesics are used for the treatment of acute and chronic pain in different disease states. A narcotic or a non-narcotic analgesic that does not cause respiratory depression and addiction is needed. In Ayurveda a large number of indigenous drugs have been mentioned possessing analgesic properties (e.g. Guggul, Erand, Rasna, Bhringaraj, Methika, Palandu and Prasikayavani). The present experimental research work was undertaken to determine the analgesic activity of the total ethanol extract of Eclipta alba, and also the isolated alkaloids of Eclipta alba in albino mice by using standard experimental models such as the tail clip method, the tail flick method and the acetic acid induced writhing response. The results from this study show that both the ethanol extract as well as the total alkaloids produce good analgesic activity in all the different models of analgesia used. The total alkaloidal fraction was the most efficacious in all models tested.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Principal K. M. Kundnani College of Pharmacy, R. G. Thadani Marg, Worli, Mumbai - 400018, India.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Sawant
authors.forename: Jolly C
authors.initials: JC
authors.lastname: Isaac
authors.forename: Shridhar
authors.initials: S
authors.lastname: Narayanan
mesh_terms: D019342:Acetic Acid; D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D036601:Eclipta; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid