Sperm protein 17 is expressed in human somatic ciliated epithelia.
It was once believed that sperm protein 17 (Sp17) was expressed exclusively in the testis and that its sole function was to bind to the oocyte during fertilization. However, immunohistochemistry of the human respiratory airways and reproductive systems show that it is abundant in ciliated cells but not in human cells with stereocilia and microvilli. The high degree of sequence conservation throughout its N-terminal half, and the presence of an A-kinase anchoring protein (AKAP)-binding motif within this region, suggest that Sp17 plays a regulatory role in a PKA-independent AKAP complex in both male germinal and ciliated somatic cells.
Grizzi
Fabio
F
Istituto Clinico Humanitas, Rozzano, Milan, Italy.
Chiriva-Internati
Maurizio
M
Franceschini
Barbara
B
Bumm
Klaus
K
Colombo
Piergiuseppe
P
Ciccarelli
Michele
M
Donetti
Elena
E
Gagliano
Nicoletta
N
Hermonat
Paul L
PL
Bright
Robert K
RK
Gioia
Magda
M
Dioguardi
Nicola
N
Kast
W Martin
WM
D000954:Antigens, Surface; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins / Q000096:biosynthesis*; D002923:Cilia / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism / Q000648:ultrastructure; D005187:Fallopian Tubes / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000648:ultrastructure; D007830:Larynx / Q000378:metabolism / Q000648:ultrastructure; D008168:Lung / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008565:Membrane Proteins; D008871:Microvilli / Q000378:metabolism; D009928:Organ Specificity; D013737:Testis / Q000378:metabolism / Q000648:ultrastructure; D014132:Trachea / Q000378:metabolism / Q000648:ultrastructure; D014649:Vas Deferens / Q000378:metabolism / Q000648:ultrastructure
D000954:Antigens, Surface; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; C090172:SPA17 protein, human