Prevention by bovine milk against Helicobacter pylori-associated atrophic gastritis through its adherence inhibition.
OBJECTIVE
The effects of Helicobacter pylori infection on the development of atrophic gastritis and intestinal metaplasia in relation to lifestyle and diet and the effect of the bovine milk on H. pylori adherence to gastric antral mucosa were investigated.


METHODS
H. pylori infection was investigated in 63 patients without endoscopic evidence of gastroduodenal disease. Presence of H. pylori infection was assessed by culture and histologic examination of antral and corpus biopsy samples. Grades of atrophic gastritis and intestinal metaplasia were judged with chromoendoscopy (Congo red-methylene blue test). Adherence of H. pylori was evaluated with scanning electron microscopic examination of antral mucosa in Mongolian gerbils.


RESULTS
Cross-sectional analysis of lifestyle and diet showed that a high intake of bovine milk was significantly related to prevention of H. pylori infection and the developments of atrophic gastritis and intestinal metaplasia. H. pylori adherence to the gastric mucosa was inhibited by bovine milk in a dose-dependent manner.


CONCLUSIONS
Bovine milk prevents the development of atrophic gastritis and intestinal metaplasia through its defense mechanisms against the attachment of H. pylori to the gastric mucosa.
Akedo
Ikuko
I
Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. akechans@aol.com
Tatsuta
Masaharu
M
Narahara
Hiroyuki
H
Iishi
Hiroyasu
H
Uedo
Noriya
N
Yano
Hiroyuki
H
Ishihara
Ryu
R
Higashino
Koji
K
Ishida
Tetsushi
T
Takemura
Koichi
K
Matsumoto
Satoru
S
D000818:Animals; D001422:Bacterial Adhesion; D004396:Coloring Agents; D016001:Confidence Intervals; D003224:Congo Red; D004032:Diet; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology; D005757:Gastritis, Atrophic / Q000382:microbiology / Q000517:prevention & control*; D016481:Helicobacter Infections / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D008019:Life Style; D008297:Male; D008751:Methylene Blue; D008875:Middle Aged; D008892:Milk; D016017:Odds Ratio
D004396:Coloring Agents; D003224:Congo Red; D008751:Methylene Blue