title: Biochemical aspects and functional role of the copper-containing amine oxidases.
abstract: The copper-containing amine oxidases of the class EC 1.4.3.6 share many biochemical similarities. They contain cupric copper and catalyse the same general reaction. In mammals, diamine oxidase has a role in the metabolism of histamine, some other diamines and spermine oxidase, involved in the metabolism of polyamines. However, the functional role of benzylamine oxidase (BAO) and the tissue semicarbazide-sensitive amine oxidases (SSAO) is still under investigation. Circulating BAO is derived from the tissue SSAO. It has a high affinity for benzylamine and its role in the extra-cellular matrix includes the maturation of pro-elastin and control of the inflammatory process.
authors.affiliation: Department of Pharmacology, University of Florence, Florence, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Buffoni
authors.forename: G
authors.initials: G
authors.lastname: Ignesti