Different hydroxyl radical scavenging activity of water-soluble beta-alanine C60 adducts.
Three C(60) derivatives [C(60) (NHCH(2)CH(2)COONa)(n)(H)(n)], n=1, 5, 9] (A, B, C) with different additional number of beta-alanine were synthesized by the control of relative amount of C(60) and beta-alanine added. Hydroxyl radical scavenging activity of the adducts was evaluated in a copper-catalyzed Haber-Weiss reaction by chemiluminescence technology. The 50% inhibition concentrations (IC(50)'s) of A, B, and C were 147.2 micromol/L, 76.3 micromol/L, and 96.2 micromol/L, respectively. The difference should be closely related to the numbers of residual C=C bonds in C(60), steric effect and electron-withstanding effect of amino group especially.
Sun
Tao
T
College of Food Science, Shanghai Fisheries University, Shanghai 200090, China. taosum@shfu.edu.cn
Jia
Zhishen
Z
Xu
Zhude
Z
D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000378:metabolism*; D017665:Hydroxyl Radical / Q000378:metabolism*; D012995:Solubility; D014867:Water / Q000378:metabolism*; D015091:beta-Alanine / Q000737:chemistry / Q000378:metabolism*
D016166:Free Radical Scavengers; D014867:Water; D015091:beta-Alanine; D017665:Hydroxyl Radical