title: Fitting the niche by genomic adaptation.
abstract: Studying microbial genomics has shown that the genomes of bacteria are extremely dynamic in evolutionary terms. Many research groups have linked the adaptation of an organism to a niche to large changes in genome size and content. A number of recent papers have underlined the degree to which the genomes of different organisms are a reflection of the opportunities and constraints imposed by their chosen niche.
authors.affiliation: Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Thomson
authors.forename: Stephen
authors.initials: S
authors.lastname: Bentley
authors.forename: Matthew
authors.initials: M
authors.lastname: Holden
authors.forename: Julian
authors.initials: J
authors.lastname: Parkhill
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity; D001424:Bacterial Infections / Q000382:microbiology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D017753:Ecosystem; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D010935:Plant Diseases / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins