title: A second life in science--working after the age of 65.
abstract: I was born in January, 1921 and was fortunate in working for a research organization that had no fixed retirement age. I was permitted to continue Science as long as there were some resources to support research that had some relevance to the organization's goals. A number of projects on which I worked were continuations of ones begun before the age of 65 (1986) and several new ones were based on both previous interests and ideas and some on new ideas. A number of the ideas arose from participation on Committees of the US National Research Council. I was able to extend my earlier interests in DNA repair to include experiments on the variations in DNA repair among apparently normal humans. In collaborations with other researchers we showed that the repair abilities following exposures to chemicals or to ionizing or ultraviolet (UV) radiation did not follow Poisson distributions. I participated in experiments, using a fish model to estimate the wavelength ranges in sunlight responsible for inducing melanoma and another fish model to estimate the germ cell mutations that might arise from exposures to the heavily ionizing particles in cosmic rays beyond low Earth orbit. A transgenic fish model was used to investigate the possibilities of using the fish to assay for mutagens in sediments in Long Island Sound. These Reflections summarize the atmosphere necessary for a second life and the scientific results of this life.
authors.affiliation: Biology Department, Brookhaven National Laboratory, P.O. Box 5000, Upton, NY 11973, USA. setlow@bnl.gov
authors.forename: Richard B
authors.initials: RB
authors.lastname: Setlow
mesh_terms: D000368:Aged; D000818:Animals; D001695:Biology; D004260:DNA Repair; D004651:Employment / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D008545:Melanoma / Q000209:etiology; D009381:Neoplasms, Radiation-Induced; D011836:Radiation Tolerance; D014481:United States