Pentoxyfylline in and prevention and treatment of chronic lung disease.
The anti-inflammatory effects of pentoxfylline are associated with a number of clinical benefits. These include reduction in mortality in patients who have undergone bone marrow transplants or suffer peritonitis. In infants with sepsis, a reduction in mortality has also been associated with pentoxyfylline administration. The anti-inflammatory effects of pentoxyfylline, as well as its bronchodilator, diuretic and respiratory muscle stimulant effects suggest it may have a useful role in BPD. Interim analysis of a prophylactic trial suggests pentoxyfylline may reduce treatment requirements after the neonatal period and that, in established BPD, pentoxyfylline and dexamethasone may be of similar efficacy.
Lauterbach
R
R
Department of Neonatology, Medical College Jagiellonian University, Cracow, Poland. lauterbach@pro.onet.pl
Pawlik
D
D
Zembala
M
M
Szymura-Oleksiak
J
J
Lisowska-Miszczyk
I
I
Kowalczyk
D
D
Bury
J
J
D002908:Chronic Disease; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D010431:Pentoxifylline / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D004791:Enzyme Inhibitors; D010431:Pentoxifylline