title: Frequency and risk factors for meningioma in clinically healthy 75-year-old patients: results of the Transdanube Ageing Study (VITA).
abstract: BACKGROUND
  The prevalence of clinically silent intracranial tumors in specific populations is poorly researched. It is known that, in advanced age groups, the number of clinically manifest meningiomas constitute a small proportion of the actual number of cases. The goals of the current study were to determine the frequency of asymptomatic patients with meningioma in advanced age and to identify risk factors for meningiomas in this population.
  
  
  METHODS
  Between May 2000 and November 2002, 532 probands from a specifically defined geographic area of Vienna who were age 75 years underwent a magnetic resonance imaging scan of the brain and were evaluated for the presence of a space-occupying mass. All probands were examined clinically and neurologically as well as by a neuropsychiatrist. The patients' medical histories were carefully documented with regard to previous diseases, medication, and lifestyle, as were their laboratory reports. The collected data were correlated and similarities among subjects with meningioma were determined.
  
  
  RESULTS
  Nine meningiomas that were unknown until the time of investigation were observed among the 318 women included in the trial (corresponding to a calculated prevalence of 2800/100,000 clinically silent meningiomas in 75-year-old women). No tumors were found among men. Associated clinical changes or deficits were not observed in any subject. Apart from advanced age and female gender, no other accepted or well known risk factors were observed in the tumor patients.
  
  
  CONCLUSIONS
  Clinically quiescent meningiomas in the elderly female population were more common than was believed to be the case to date. Known and influenceable risk factors were found to be less important than age and gender. The high frequency of this lesion should be considered when deciding on the treatment of patients with incidentally discovered, clinically quiescent meningiomas.
authors.affiliation: Department of Radiology, Danube Hospital, Vienna, Austria. wolfgang.krampla@wienkav.at
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Krampla
authors.forename: Stephan
authors.initials: S
authors.lastname: Newrkla
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Pfisterer
authors.forename: Susanne
authors.initials: S
authors.lastname: Jungwirth
authors.forename: Peter
authors.initials: P
authors.lastname: Fischer
authors.forename: Thomas
authors.initials: T
authors.lastname: Leitha
authors.forename: Walter
authors.initials: W
authors.lastname: Hruby
authors.forename: Karl Heinz
authors.initials: KH
authors.lastname: Tragl
mesh_terms: D000368:Aged; D000375:Aging / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000453:epidemiology*; D008579:Meningioma / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors