Muscle differentiation: a gene for slow muscle?
Skeletal muscle comes in two fundamental flavours, slow and fast, which determine physiological performance. Zebrafish screens have provided a handle on the molecular mechanism driving slow muscle formation. The transcriptional repressor Blimp1 has now been shown to be required in embryonic slow muscle precursor cells.
Hughes
Simon M
SM
Randall Centre for Molecular Cell Biology, King's College London, London SE1 1UL, UK. simon.hughes@kcl.ac.uk
D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins; D005786:Gene Expression Regulation; D053823:Hedgehog Proteins; D024510:Muscle Development; D018657:Muscle Fibers, Slow-Twitch / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000196:embryology*; D032448:Myoblasts, Skeletal / Q000166:cytology*; D009687:Nuclear Proteins; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D015027:Zebrafish; D029961:Zebrafish Proteins
D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; D009687:Nuclear Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D029961:Zebrafish Proteins; D000074462:Positive Regulatory Domain I-Binding Factor 1; C513257:prdm1a protein, zebrafish