Haemodynamic crisis and reversible multiorgan failure caused by HIV post-exposure prophylaxis after needle-stick injury in a health care worker.
We report the case of a 59-year-old nurse from our HIV ward who developed a severe haemodynamic crisis with concomitant acute multiorgan failure after initiation of a post-exposure prophylaxis (PEP) with zidovudine/lamivudine (CombivirTM) and lopinavir/ritonavir (KaletraTM) after a needle-stick injury with an HIV-contaminated needle. Although serious and life-threatening adverse effects of post-exposure prophylaxis have been documented in several cases, this is the first report of a severe acute cardiovascular incident following PEP initiation.
Feldt
T
T
Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany. Feldt@med.uni-duesseldorf.de
Oette
M
M
Goebels
K
K
Wenning
M
M
Kroidl
A
A
Häussinger
D
D
D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000150:complications; D016602:Needlestick Injuries / Q000150:complications*; D009726:Nurses; D016273:Occupational Exposure / Q000009:adverse effects*