title: A southpaw joins the roster: the role of the zebrafish nodal-related gene southpaw in cardiac LR asymmetry.
abstract: The establishment of the left-right (LR) asymmetry of the zebrafish heart involves at least two discrete events: cardiac jogging and cardiac looping. The nodal-related gene southpaw is required for both aspects of heart LR asymmetry as well as for LR patterning of other visceral organs. Reductions in southpaw activity abolish the normal LR biases of jogging and looping and uncouple the normal correlation between jogging and looping polarities. These loss-of-function experiments also reveal that southpaw is required for organizing at least the initial phase of diencephalic LR asymmetry and suggest that heart and brain LR patterning may be coordinated by southpaw signaling originating within the anterior, left lateral plate mesoderm.
authors.affiliation: Department of Anatomy and Cell Biology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Nadira
authors.initials: N
authors.lastname: Ahmad
authors.forename: Sarah
authors.initials: S
authors.lastname: Long
authors.forename: Michael
authors.initials: M
authors.lastname: Rebagliati
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D004627:Embryonic Induction / Q000235:genetics; D005318:Fetal Heart / Q000254:growth & development; D005326:Fetal Proteins / Q000235:genetics / Q000502:physiology; D006321:Heart / Q000196:embryology; D006330:Heart Defects, Congenital / Q000196:embryology / Q000235:genetics*; D006801:Humans; D009024:Morphogenesis / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D015027:Zebrafish
chemical_list: D005326:Fetal Proteins; D014157:Transcription Factors