Survival signaling in resting B cells.
The survival of mature resting B cells in the periphery depends on signaling from the B-cell receptor (BCR) and the B-cell activating factor of the TNF family receptor (BAFF-R). Engagement of both receptors promotes NF-kappa B activity, which contributes to B-cell survival through different pathways. BCR signaling leads to activation of the inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha. Proximal signaling intermediates are potentially common to both pathways. We suggest that BCR and BAFF-R survival signaling are mutually dependent. In addition, we propose that BAFF-R signaling enhances the expression of survival genes through direct chromatin modifications in NF-kappa B target gene promoters.
Patke
Alina
A
Laboratory of Lymphocyte Signaling, The Rockefeller University, 1230 York Avenue, Box 301, New York, NY 10021, USA.
Mecklenbräuker
Ingrid
I
Tarakhovsky
Alexander
A
D000818:Animals; D053265:B-Cell Activation Factor Receptor; D001402:B-Lymphocytes / Q000378:metabolism*; D002470:Cell Survival; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D015398:Signal Transduction
D053265:B-Cell Activation Factor Receptor; D008565:Membrane Proteins; D016328:NF-kappa B; D018124:Receptors, Tumor Necrosis Factor; C486662:Tnfrsf13c protein, mouse