[Angiotensin converting enzyme (ACE, CD143) in the regular pulmonary vasculature].
Angiotensin I converting enzyme (ACE, CD143) is an endothelial transmembrane Zn2+-dipeptidylpeptidase. By formation of angiotensin II and degrading bradykinin it acts as a vasoconstrictor. We examined endothelial ACE expression in human pulmonary vessels in specimens from 20 female and 19 male patients (age: 34-76 years) by immunohistochemistry. In all specimens, capillary endothelial cells showed the strongest expression, followed by those in arterioles and arteries. Venules and veins showed next to no staining. The differences in staining intensities were significant ( P<0.001). Sex affected neither the expression intensity nor the expression pattern. Summarizing, we demonstrate the existence of a vessel-type specific ACE expression pattern for pulmonary vessels. The nearly exclusive endothelial ACE expression in capillaries and arterial vessels points to ACE as an immunohistochemical marker for these vessels in normal lung tissue.
Müller
A M
AM
Institut für Pathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil-Universitätsklinik, Bergmannsheil der Ruhr-Universität Bochum, Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. annette.mueller@ruhr-uni-bochum.de
Gruhn
K
K
Lange
S
S
Franke
F E
FE
Müller
K-M
KM
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000098:blood supply / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011651:Pulmonary Artery / Q000201:enzymology*; D011667:Pulmonary Veins / Q000201:enzymology*
D007703:Peptidyl-Dipeptidase A