title: A highly regio- and stereoselective carbocupration of fluoroalkylated internal alkynes: a short total synthesis of the antiestrogenic drug panomifene.
abstract: [reaction: see text] A highly regio- and stereoselective carbometalation reaction of fluoroalkylated internal alkynes with organocopper reagents is described. This reaction is utilized successfully in the short, stereoselective total synthesis of the antiestrogenic drug panomifene.
authors.affiliation: Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. konno@chem.kit.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Konno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Daitoh
authors.forename: Atsushi
authors.initials: A
authors.lastname: Noiri
authors.forename: Jungha
authors.initials: J
authors.lastname: Chae
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishihara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamanaka