Use of cidofovir in polyomavirus BK viral nephropathy in two renal allograft recipients.
Polyomavirus BK viral allograft nephropathy is a potentially reversible cause of deteriorating function of kidney allografts. Initial treatment involves reducing immunosuppressive medications, with low-dose cidofovir an effective alternative in refractory cases. We describe two cases of BK viral allograft nephropathy responding to low-dose cidofovir after a reduction in immunosuppressive medications failed to clear the virus or stabilize the deterioration in renal function. There were no significant side-effects from this treatment in either patient.
Lim
Wai H
WH
Renal Unit and Department of Pathology, The Queen Elizabeth Hospital, Woodville, South Australia, Australia. wandm@senet.com.au
Mathew
Timothy H
TH
Cooper
John E
JE
Bowden
Scott
S
Russ
Graeme R
GR
D000998:Antiviral Agents / Q000627:therapeutic use*; D001739:BK Virus; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000601:surgery / Q000821:virology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D027601:Polyomavirus Infections / Q000188:drug therapy*; D014184:Transplantation, Homologous; D014412:Tumor Virus Infections / Q000188:drug therapy*
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir