title: Features described and illustrated in 1684 suggesting Meckel-Gruber syndrome.
abstract: In 1684, Mr. Christopher Krahe described a monstrous child, born in Denmark on Friday, February 29, 1684. The description is suggestive of a diagnosis of Meckel-Gruber syndrome (dysencephalia splanchnocystica). This may represent the oldest description and illustration of the syndrome, of which the first detailed description is attributed to Johann Friedrich der Jüngere in 1822.
authors.affiliation: Department of Neurosurgery, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. e.j.o.kompanje@erasmusmc.nl
authors.forename: Erwin J O
authors.initials: EJ
authors.lastname: Kompanje
mesh_terms: D000015:Abnormalities, Multiple / Q000266:history*; D004677:Encephalocele / Q000196:embryology; D049670:History, 17th Century; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D017689:Polydactyly / Q000196:embryology