Role of the coagulation/fibrinolysis system in fibrin-associated glomerular injury.
In the past decade, numerous experimental studies of genetically engineered mice have confirmed the involvement of the coagulation/fibrinolysis system during glomerular inflammation and repair, revealing many unexpected biologic effects far beyond fibrin formation and clearance. Resident glomerular cells and macrophages seem to act in concert to ensure the long-term consolidation of local injury and progression toward glomerulosclerosis. These recent advances will probably pave the way to a new therapeutic approach to renal diseases. However, the balance governing glomerular permeability is very delicate, and many issues will have to be dealt with before targeting this system.
Hertig
Alexandre
A
Department of Nephrology A and INSERM U489, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.
Rondeau
Eric
E
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology; D005337:Fibrin / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology*; D005920:Glomerular Mesangium / Q000166:cytology; D005921:Glomerulonephritis / Q000209:etiology*; D006801:Humans; D008074:Lipoproteins / Q000502:physiology; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology; D013917:Thrombin / Q000502:physiology; D000979:alpha-2-Antiplasmin / Q000502:physiology
D008074:Lipoproteins; D017395:Plasminogen Activator Inhibitor 1; D000979:alpha-2-Antiplasmin; C051928:lipoprotein-associated coagulation inhibitor; D005337:Fibrin; D013917:Thrombin