[Effects of cyclosporin A or betamethasone on experimental murine toxocariasis].
The effects of administration of either cyclosporin A or betamethasone 15 days before or 45 days after experimental infection with Toxocara canis on mice had been studied. The dynamics of IgG antibody production, employing an enzyme-linked immunosorbent assay, was studied 60 and 90 days after mice infection by Toxocara canis. In the 90th day after infection all surviving mice were sacrificed and the tissue trapped larvae recovered by acid digestion in the muscles, lungs, liver and brain. A significative delay in the production of IgG antibodies anti-Toxocara was observed in all the mice treated with cyclosporin A or betamethasone 15 days before infection. On the other side, mice treated with cyclosporine 15 days before infection, but not with betamethasone, showed a significative higher number of trapped Toxocara canis larvae in the examined tissues.
Lescano
Susana A Zevallos
SA
Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Brasil.
Chieffi
Pedro Paulo
PP
Ikai
Denise Katia
DK
Ribeiro
Manoel Carlos S A
MC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000909:Antibodies, Helminth / Q000187:drug effects / Q000276:immunology; D001623:Betamethasone / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007074:Immunoglobulin G / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D017166:Toxocara canis / Q000187:drug effects* / Q000276:immunology; D014120:Toxocariasis / Q000188:drug therapy* / Q000276:immunology
D000893:Anti-Inflammatory Agents; D000909:Antibodies, Helminth; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001623:Betamethasone