Congenital fibrosarcoma with metastasis in a fetus.
It is well known that congenital or infantile fibrosarcoma has a much less aggressive behavior than fibrosarcoma in adults, and it rarely metastasizes. We report a case of congenital fibrosarcoma in a 26-wk-old fetus, the diagnosis of which was made by an in utero needle core biopsy. Metastatic tumors were identified at autopsy when the pregnancy was terminated 3 wk later. English literature of metastatic congenital fibrosarcoma was also reviewed.
Nonaka
Daisuke
D
Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Sun
Chen-Chih J
CC
D000310:Adrenal Gland Neoplasms / Q000556:secondary; D000328:Adult; D005260:Female; D005354:Fibrosarcoma / Q000151:congenital* / Q000235:genetics / Q000556:secondary*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary; D008854:Microscopy, Electron; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011247:Pregnancy; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012983:Soft Tissue Neoplasms / Q000151:congenital* / Q000235:genetics / Q000473:pathology*; D020812:Receptor, trkC; D000097764:ETS Translocation Variant 6 Protein
D015514:Oncogene Proteins, Fusion; C484319:ETV6-NTRK3 fusion protein, human; D020812:Receptor, trkC; D000097764:ETS Translocation Variant 6 Protein