The damage-response framework of microbial pathogenesis.
The late twentieth century witnessed the emergence of numerous infectious diseases that are caused by microorganisms that rarely cause disease in normal, healthy immunocompetent hosts. The emergence of these diseases shows that the existing concepts of pathogenicity and virulence do not take into account the fact that both the microorganism and the host contribute to microbial pathogenesis. To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework.
Casadevall
Arturo
A
Departments of Medicine (Division of Infectious Diseases) and Microbiology & Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. casadeva@aecom.yu.edu
Pirofski
Liise-anne
LA
D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D018407:Bacterial Physiological Phenomena; D005658:Fungi / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007239:Infections / Q000469:parasitology / Q000473:pathology / Q000821:virology; D009181:Mycoses / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D010271:Parasites / Q000472:pathogenicity* / Q000502:physiology; D013997:Time Factors; D014774:Virulence; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000472:pathogenicity*