title: [Histoid leprosy with erythema nodosum leprosum].
abstract: Histoid leprosy is a particular variant of lepromatous leprosy presenting as cutaneous or subcutaneous nodular and/or plaque-like lesions arising form apparently normal skin. It is characterized histologically by spindle-shaped histiocytes in interlacing bundles and whorls, containing numerous intact and rod-shaped Mycobacterium leprae. It can occur de novo or secondary in patients treated for a long course by dapsone alone. We describe a case of lepromatous leprosy treated according to the national Moroccan protocol who developed histoid lesions during his treatment by dapsone. The patient responded well to fluoroquinolone, rifampicin and clofazimine, with however, the occurrence of erythema nodosum leprosum.
authors.affiliation: Service de Dermatologie, Hôpital Militaire d'instruction Mohammed-V, Rabat, Maroc.
authors.forename: Z
authors.initials: Z
authors.lastname: Alioua
authors.forename: M
authors.initials: M
authors.lastname: Sbai
authors.forename: M
authors.initials: M
authors.lastname: Elhaouri
authors.forename: A
authors.initials: A
authors.lastname: Bouzidi
authors.forename: O
authors.initials: O
authors.lastname: Boudi
authors.forename: M
authors.initials: M
authors.lastname: Ghfir
authors.forename: S
authors.initials: S
authors.lastname: Benomar
authors.forename: O L
authors.initials: OL
authors.lastname: Sedrati
mesh_terms: D000328:Adult; D002991:Clofazimine / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D004893:Erythema Nodosum / Q000188:drug therapy / Q000473:pathology*; D024841:Fluoroquinolones / Q000627:therapeutic use; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use; D015440:Leprosy, Lepromatous / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009166:Mycobacterium leprae / Q000302:isolation & purification; D012293:Rifampin / Q000627:therapeutic use
chemical_list: D024841:Fluoroquinolones; D007917:Leprostatic Agents; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin