title: Azurocidin-specific-ANCA-related idiopathic necrotizing crescentic glomerulonephritis.
abstract: An 80-year-old woman who had rapidly progressive glomerulonephritis unaccompanied by systemic vasculitis is described. On renal biopsy, she showed necrotizing crescentic glomerulonephritis by light microscopy and pauci-immune glomerular lesions by immunofluorescent study. No dense deposits were present on electronmicroscopic study. On serum examination, indirect immunofluorescent study showed perinuclear pattern antineutrophil cytoplasmic antibody (ANCA), but myeloperoxidase-ANCA and proteinase 3-ANCA were both negative. Her serum reacted only to azurocidin excluding other ANCA antigens: bactericidal permeability-increasing protein, cathepsin G, elastase, lactoferrin, or lysozyme. Serum creatinine level decreased, and C-reactive protein turned negative after steroid therapy. Azurocidin-ANCA also turned negative. It is suggested that azurocidin-ANCA might have been related to the inflammatory process of pauci-immune necrotizing crescentic glomerulonephritis in this patient.
authors.affiliation: First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan. rio@ac.catv.ne.jp
authors.forename: Rio
authors.initials: R
authors.lastname: Kimura
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsuzawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Arimura
authors.forename: Akinori
authors.initials: A
authors.lastname: Soejima
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Nakabayashi
authors.forename: Akira
authors.initials: A
authors.lastname: Yamada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000473:pathology; D006801:Humans
chemical_list: C062991:AZU1 protein, human; D019268:Antibodies, Antineutrophil Cytoplasmic; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D002352:Carrier Proteins