title: Copper sulfate-pentahydrate-1,10-phenanthroline catalyzed amidations of alkynyl bromides. Synthesis of heteroaromatic amine substituted ynamides.
abstract: A practical cross-coupling of amides with alkynyl bromides using catalytic CuSO(4).5H(2)O and 1,10-phenanthroline is described here. This catalytic protocol is more environmentally friendly than the use of CuCN or copper halides and provides a general entry for syntheses of ynamides including various new sulfonyl and heteroaromatic amine substituted ynamides. Given the interest in ynamides, this N-alkynylation of amides should be significant for the future of ynamides in organic synthesis.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Yanshi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
authors.forename: Michael R
authors.initials: MR
authors.lastname: Tracey
authors.forename: Kimberly C M
authors.initials: KC
authors.lastname: Kurtz
authors.forename: Eymi L
authors.initials: EL
authors.lastname: Vera