[Protective effect of curcumin on experimental liver injury in mice].
OBJECTIVE
To Study the protective effect of curcumin on three models of experimental liver injury in mice.


METHODS
The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.


RESULTS
Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.


CONCLUSIONS
Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.
Liu
Yong-gang
YG
Department of Pharmacology, First Military Medical University, Guangzhou 510515, Guandong, China.
Chen
Hou-chang
HC
Jiang
Yi-ping
YP
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury; D003474:Curcumin / Q000494:pharmacology*; D005688:Galactosamine; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000097:blood* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000097:blood; D020011:Protective Agents / Q000494:pharmacology*
C042138:BCG lipopolysaccharide; D008070:Lipopolysaccharides; D020011:Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003474:Curcumin