title: Recombinant interferon gamma lb and low dose steroid in two pediatric cases of nonspecific interstitial pneumonia.
abstract: We report two young girls, the first almost 18 years old and the second 12 1/2 years old, affected with nonspecific interstitial pneumonia, both diagnosed at the age of 11 by open lung biopsy and both being treated with low-dose steroid. Due to insufficient response to conventional therapy and based on positive therapeutic results following the use of subcutaneous recombinant interferon gamma-1b in fibrosing interstitial pneumonias of adults, they were given a 1-year trial of subcutaneous recombinant interferon gamma-lb in association with a steroid. Our experience with these two young patients suggests that interferon gamma-lb cannot be considered as stabilizing or a curative therapy to control or reverse nonspecific interstitial pneumonia unresponsive to steroids alone.
authors.affiliation: Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Policlinico A. Gemelli, Largo A. Gemelli, 8 00168 Rome, Italy. icple@rm.unicatt.it
authors.forename: Donato
authors.initials: D
authors.lastname: Rigante
authors.forename: Angelica Bibiana
authors.initials: AB
authors.lastname: Delogu
authors.forename: Gilda
authors.initials: G
authors.lastname: Federico
authors.forename: Gabriella
authors.initials: G
authors.lastname: De Rosa
authors.forename: Achille
authors.initials: A
authors.lastname: Stabile
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000188:drug therapy* / Q000503:physiopathology; D011241:Prednisone / Q000627:therapeutic use*; D011994:Recombinant Proteins; D012129:Respiratory Function Tests
chemical_list: D011994:Recombinant Proteins; D007371:Interferon-gamma; D011241:Prednisone