title: Poly(ethylene oxide) surfactant polymers.
abstract: We report on a series of structurally well-defined surfactant polymers that undergo surface-induced self-assembly on hydrophobic biomaterial surfaces. The surfactant polymers consist of a poly(vinyl amine) backbone with poly(ethylene oxide) and hexanal pendant groups. The poly(vinyl amine) (PVAm) was synthesized by hydrolysis of poly(N-vinyl formamide) following free radical polymerization of N-vinyl formamide. Hexanal and aldehyde-terminated poly(ethylene oxide) (PEO) were simultaneously attached to PVAm via reductive amination. Surfactant polymers with different PEO:hexanal ratios and hydrophilic/hydrophobic balances were prepared, and characterized by FT-IR, 1H-NMR and XPS spectroscopies. Surface active properties at the air/water interface were determined by surface tension measurements. Surface activity at a solid surface/water interface was demonstrated by atomic force microscopy, showing epitaxially molecular alignment for surfactant polymers adsorbed on highly oriented pyrolytic graphite. The surfactant polymers described in this report can be adapted for simple non-covalent surface modification of biomaterials and hydrophobic surfaces to provide highly hydrated interfaces.
authors.affiliation: Department of Macromolecular Science, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Katanchalee
authors.initials: K
authors.lastname: Vacheethasanee
authors.forename: Shuwu
authors.initials: S
authors.lastname: Wang
authors.forename: Yongxing
authors.initials: Y
authors.lastname: Qiu
authors.forename: Roger E
authors.initials: RE
authors.lastname: Marchant
mesh_terms: D000447:Aldehydes / Q000032:analysis / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004577:Electron Probe Microanalysis; D006108:Graphite / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D008958:Models, Molecular; D015394:Molecular Structure; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011145:Polyvinyls / Q000138:chemical synthesis / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013500:Surface Tension; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D020099:Coated Materials, Biocompatible; D011108:Polymers; D011145:Polyvinyls; D013501:Surface-Active Agents; D014867:Water; C008996:poly(vinylamine); D011092:Polyethylene Glycols; D006108:Graphite; C010463:n-hexanal