[Effects of a novel recombinant polypeptide from the sea anemone Anthopleura sp. on left ventricular function in New Zealand rabbits with chronic congestive heart failure].
OBJECTIVE
To observe the effects of recombinant hk2a, a novel neurotoxin from the sea anemone Anthopleura sp. on the left ventricular function in New Zealand rabbits with chronic congestive heart failure(CCHF).


METHODS
CHF model was established using New Zealand rabbits by abdominal aortic coarctation. The left ventricular ejection fraction (LVEF) was measured by Acuson ultrasound systems (Sequoia 512) at 0, 5, 15, 30, 45 and 60 min respectively after intravenous injection with a single dose of recombinant hk2a (20 microg/kg x b x w.). The response of the rabbits to hk2a treatment was observed in comparison with that of the control group.


RESULTS
Recombinant hk2a immediately and significantly increased the left ventricular ejection fraction of the rabbit models of CCHF after intravenous injection (P<0.05), and its effects were maintained for more than 1 h without affecting the heart rate.


CONCLUSIONS
recombinant hk2a significantly increases the left ventricular ejection fraction in New Zealand rabbits with CCHF.
Liu
Yan-bo
YB
Department of Cardiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. liuyanbo.cn@163.com
Wang
Peng
P
Ouyang
Ping
P
Xu
Ding-li
DL
Wang
Lei
L
Wang
Yong-hua
YH
Liang
Dong
D
Wu
Ping-sheng
PS
Xu
An-long
AL
D000818:Animals; D003064:Cnidarian Venoms / Q000494:pharmacology*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000187:drug effects*
D003064:Cnidarian Venoms; D011994:Recombinant Proteins