[Effects of conjugated linoleic acid on obese MSG mice with insulin resistance].
OBJECTIVE
To study the effect of conjugated linoleic acid (CLA) on obese MSG mice with insulin resistance.


METHODS
About four months old, obese MSG mice with insulin resistance were divided into control, CLA and rosiglitazone groups and drugs were administrated ig once a day. Body weights were recorded regularly, insulin and glucose tolerance were tested. In addition, serum insulin and TNF-alpha concentrations in serum and fat tissues were determined.


RESULTS
CLA was shown to reduce the body weight and fat weight in MSG mice, but can not improve the abnormal insulin and glucose tolerance in these mice. Indeed, the serum insulin and TNF-alpha concentrations in the fat tissues of the group treated with CLA were higher than those in the models and the insulin sensitivity index was significantly lower than that in the model mice.


CONCLUSIONS
CLA can reduce the body weight of MSG mice, but can not improve the insulin resistance in these mice.
Sun
Su-juan
SJ
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China.
Shen
Zhu-fang
ZF
Chen
Yue-teng
YT
Tang
Ling
L
Ding
Shi-ying
SY
Xie
Ming-zhi
MZ
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D044243:Linoleic Acids, Conjugated / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism*; D012970:Sodium Glutamate; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001786:Blood Glucose; D007328:Insulin; D044243:Linoleic Acids, Conjugated; D014409:Tumor Necrosis Factor-alpha; D012970:Sodium Glutamate