title: Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption.
abstract: OBJECTIVE
  To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.
  
  
  METHODS
  A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.
  
  
  METHODS
  A university hospital with 3700 deliveries per year.
  
  
  METHODS
  Seventy cases with severe preeclampsia, IUGR or placental abruption.
  
  
  METHODS
  Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.
  
  
  METHODS
  Gestational age at delivery, birth weight and early neonatal complications.
  
  
  RESULTS
  Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.
  
  
  CONCLUSIONS
  Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah University Hospital, P.O. Box 24035, Mt. Scopus, Jerusalem, Israel. anteby@cc.huji.ac.il
authors.forename: Eyal Y
authors.initials: EY
authors.lastname: Anteby
authors.forename: Banan
authors.initials: B
authors.lastname: Musalam
authors.forename: Ariel
authors.initials: A
authors.lastname: Milwidsky
authors.forename: Anat
authors.initials: A
authors.lastname: Blumenfeld
authors.forename: Shmuel
authors.initials: S
authors.lastname: Gilis
authors.forename: Dan
authors.initials: D
authors.lastname: Valsky
authors.forename: Yaron
authors.initials: Y
authors.lastname: Hamani
mesh_terms: D000037:Abruptio Placentae / Q000235:genetics; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000235:genetics*; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications; D012720:Severity of Illness Index; D019851:Thrombophilia / Q000235:genetics*
chemical_list: C095381:factor V Leiden; D005165:Factor V