title: Massive nasal bleeding and hemodynamic instability associated with clopidogrel.
abstract: A 58-year-old woman was brought to our emergency department with massive nasal bleeding and hemodynamic instability. The patient had been on clopidogrel treatment (75 mg/day) for 2 years, which was started after an episode of transitory ischemic attack. Blood pressure normalized following the administration of intravenous fluids, and the bleeding stopped after nasal tamponade and desmopressin therapy.
authors.affiliation: Clinical Research Center & Intensive Care Medicine, Clínica São Vicente, Rua João Borges 204, Rio de Janeiro, RJ 22451-100, Brazil. pesquisa@svgavea.com.br
authors.forename: Flávio E
authors.initials: FE
authors.lastname: Nácul
authors.forename: Emanuela
authors.initials: E
authors.lastname: de Moraes
authors.forename: Carmen
authors.initials: C
authors.lastname: Penido
authors.forename: Roberto B
authors.initials: RB
authors.lastname: Paiva
authors.forename: João G C
authors.initials: JG
authors.lastname: Méier-Neto
mesh_terms: D000077144:Clopidogrel; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D004844:Epistaxis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects* / Q000031:analogs & derivatives*
chemical_list: D006490:Hemostatics; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D003894:Deamino Arginine Vasopressin; D013988:Ticlopidine