[The influence on hemodynamics of myocardial ischemic dogs and blood pressure of animals with shenfu injection].
OBJECTIVE
To investigate the influence of Shenfu injection on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of dogs and rats.


METHODS
Myocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10 mL.kg-1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats.


CONCLUSIONS
Shenfu injection enhanced the capacity of myocardial work markedly; it augmented the myocardium contractility and cardiac output without raising the oxygen consume, and at the same time it returned normal the blood pressure in myocardial ischemic; but it had no effects on the normal blood pressure and secondary hypertension of rats.
Yang
Fang-ju
FJ
School of Basic Medical Science and Medical Jurisprudence of Sichuan University, Chengdu 610041, Sichuan, China. yang Fangju hotmail
Wang
Zheng-rong
ZR
Lin
Dai-ping
DP
Qu
Yi
Y
Yin
Hua-hu
HH
Shi
Li-li
LL
Guo
Hui-ling
HL
Xiao
Jing
J
Wang
Yue-qi
YQ
Liu
Rong-tao
RT
D031841:Aconitum / Q000737:chemistry; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology; D007267:Injections; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D044005:Tetrahydroisoquinolines / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D044005:Tetrahydroisoquinolines; C012348:higenamine