title: Design, synthesis and in vitro antitumor activity of new trans 2-[2-(heteroaryl)vinyl]-1,3-dimethylimidazolium iodides.
abstract: The design, the synthesis, and the in vitro antitumor activities of trans 2-[2-(heteroaryl)vinyl]-1,3-dimethylimidazolium iodides versus MCF7 (human mammary carcinoma) and LNCap (prostate carcinoma) cell lines are reported. The design indicates trans 2-[2-[5-(2-chlorophenyl)furan-2-yl]vinyl]-1, 3-dimethylimidazolium iodide 5 and trans 2-[2-[5-(4-bromophenyl)furan-2-yl]vinyl]-1, 3-dimethylimidazolium iodide 6 as highly active compounds in the series. The synthesis of the above new derivatives and in vitro antitumor tests, confirm their significant antiproliferative and cytotoxic activities.
authors.affiliation: Dipartimento Scienze Chimiche, Università di Catania, V.le A.Doria 6, 95125, Catania, Italy.
authors.forename: Francesco P
authors.initials: FP
authors.lastname: Ballistreri
authors.forename: Vincenza
authors.initials: V
authors.lastname: Barresi
authors.forename: Paolo
authors.initials: P
authors.lastname: Benedetti
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Caltabiano
authors.forename: Cosimo G
authors.initials: CG
authors.lastname: Fortuna
authors.forename: Maria L
authors.initials: ML
authors.lastname: Longo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Musumarra
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007454:Iodides / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D007454:Iodides