Can food intake be reduced with peptide YY3-36?
Obesity shortens life expectancy. The peripheral administration of peptide YY3-36 (PYY3-36) inhibits food intake in mice and rats. The effects of PYY3-36 on food intake have been assessed in obese and lean subjects in a double-blind, placebo-controlled, cross-over study. In fasting obese and lean subjects, infusion of PYY3-36 reduced the caloric intake in 24 h by 17 and 24%, respectively. Long-term studies to determine whether PYY3-36 reduces food intake in freely fed humans are now required.
Doggrell
Sheila A
SA
Doggrell Biomedical Communications, Lynfield, Auckland, New Zealand. s_doggrell@yahoo.com
D000328:Adult; D001067:Appetite Depressants / Q000494:pharmacology*; D015992:Body Mass Index; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D005215:Fasting / Q000502:physiology; D005260:Female; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D010446:Peptide Fragments; D036361:Peptide Hormones / Q000097:blood; D019894:Peptide YY / Q000494:pharmacology*
D001067:Appetite Depressants; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D010446:Peptide Fragments; D036361:Peptide Hormones; D019894:Peptide YY; C061785:peptide YY (3-36)