title: Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract.
abstract: A methanol extract of the dried leaves of Tithonia diversifolia was investigated for anti-inflammatory and analgesic activities. The extract (50-200 mg/kg, p.o.) produced dose-related inhibition of carrageenan-induced paw oedema and cotton pellet-induced granuloma in rats. At the same doses, analgesic effect was also observed with hot plate latency assays maintained at (55 degrees C) as well as on the early and late phases of formalin-induced paw licking in rats. The results of the present study further confirm the use of Tithonia diversifolia traditionally for the treatment of painful inflammatory conditions.
authors.affiliation: Department of Physiology and Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria. deleyele@yahoo.com
authors.forename: Victor B
authors.initials: VB
authors.lastname: Owoyele
authors.forename: Caleb O
authors.initials: CO
authors.lastname: Wuraola
authors.forename: Ayodele O
authors.initials: AO
authors.lastname: Soladoye
authors.forename: Samuel B
authors.initials: SB
authors.lastname: Olaleye
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D019659:Asteraceae; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts