Quantification of Epstein-Barr viral load and determination of a cut-off value to predict the risk of post-transplant lymphoproliferative disease in a renal transplant cohort.
Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening Epstein-Barr virus (EBV)-driven B-cell malignancy occurring in 1 to 3% of renal transplant patients. Recently, EBV DNA quantification has become a useful tool for identifying patients at risk of developing PTLD. However, studies on EBV load differ in design, methodology and type of patients.
Baiocchi
Otávio C G
OC
Colleoni
Gisele W B
GW
Caballero
Otávia L
OL
Vettore
André L
AL
Andrade
Ana Lucia S S
AL
Pestana
José O M
JO
D000328:Adult; D016022:Case-Control Studies; D020031:Epstein-Barr Virus Infections / Q000097:blood*; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D019562:Viral Load