Reactive oxygen species and sperm cells.
There is a dynamic interplay between pro- and anti-oxidant substances in human ejaculate. Excessive reactive oxygen species (ROS) generation can overwhelm protective mechanism and initiate changes in lipid and/or protein layers of sperm plasma membranes. Additionally, changes in DNA can be induced. The essential steps of lipid peroxidation have been listed as well as antioxidant substances of semen. A variety of detection techniques of lipid peroxidation have been summarized together with the lipid components of sperm membranes that can be subjected to stress. It is unsolved, a threshold for ROS levels that may induce functional sperm ability or may lead to male infertility.
Sanocka
Dorota
D
Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.sanodor@man.poznan.pl
Kurpisz
Maciej
M
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism* / Q000502:physiology
D000975:Antioxidants; D005609:Free Radicals; D008563:Membrane Lipids; D017382:Reactive Oxygen Species