title: Castleman's disease of the neck: a description of four cases on contrast-enhanced CT.
abstract: Castleman's disease of the neck is an uncommon benign lymphoproliferative disease that usually presents as homogeneously enhancing enlarged lymph nodes on contrast-enhanced CT scan. We described the appearance of four confirmed cases of Castleman's disease of the neck on contrast-enhanced CT scan. Three of these presented as a solitary enhancing lymph node and the fourth case presented with multiple bilateral enhancing lymph nodes. A central non-enhancing area was present in two of the three cases that presented as a solitary node. Pathological correlation of one of these cases showed that this was due to a central fibrotic scar. One of the enhancing nodes in the fourth case with multiple and bilateral lymphadenopathy also contained a central non-enhancing area. We would like to propose that if a central non-enhancing scar is observed in an enhancing lymph node in the neck on CT scan, Castleman's disease should be considered as a possible diagnosis.
authors.affiliation: Department of Radiology, Changi General Hospital, Singapore.
authors.forename: T Y
authors.initials: TY
authors.lastname: Tan
authors.forename: K P
authors.initials: KP
authors.lastname: Pang
authors.forename: H K C
authors.initials: HK
authors.lastname: Goh
authors.forename: E L H
authors.initials: EL
authors.lastname: Teo
authors.forename: B
authors.initials: B
authors.lastname: Abhilash
authors.forename: N
authors.initials: N
authors.lastname: Walford
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005871:Castleman Disease / Q000000981:diagnostic imaging*; D002648:Child; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media