[Studies on new trierpenoid constituents from the Rhizoma of Cimicifuga foetida].
OBJECTIVE
To find new active constituents from Rhizome of Cimicifuga foetida.


METHODS
Various column chromatographic techniques were employed for isolation and purification. The structures were elucidated on the basis of spectral and chemical evidences.


RESULTS
Four triterpenoid compounds were isolated and identified as 7,8-didehydro-27-deoxyactein(1), 24-O-acetylshengmanol-3-O-beta-D-xyl (23R, 24R)[2], cimigenol(3), cimigenol-3-O-beta-D-xyl(4).


CONCLUSIONS
Compound 1 is a new compound, 2-4 were obtained from this medicinal material for the first time. The antiosteoporosis activity screening in vitro(by the method of SRB) indicates that Compounds 1, 2 and 4 can promote the proliferation for rat Osteoblastoma cell line (UMR106) at the concentration of 10(-9) kg.L-1.
Zhao
Xiao-hong
XH
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
Chen
Di-hua
DH
Si
Jian-yong
JY
Pan
Rui-le
RL
Shen
Lian-gang
LG
Chen
Duo
D
D000818:Animals; D001859:Bone Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D031885:Cimicifuga / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D018215:Osteoblastoma / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D027343:Rhizome / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C478830:(23R,24S)-16,23-16,24-diepoxy-9,19-cyclolanostan-3beta,15alpha,25-triol; D014315:Triterpenes; D007810:Lanosterol; C487050:7,8-didehydro-27-deoxyactein