[Studies on therapeutic effects of zhenzhu qishi wan on stroke and hypertension of SHRsp].
OBJECTIVE
To study the effect of Zhenzhu Qishi Wan on blood pressure(BP), body weight(BW), stroke and survival rate of stroke-prone spontaneously hypertension rats(SHRsp).


METHODS
8-week-old SHRsp was randomly divided into three groups: control group, Zhenzhu Qishi Wan prevention group and therapy group (n = 10). SHRsp of prevention group were treated with Zhenzhu Qishi Wan by ig 150 mg.kg-1 per day for 6 weeks, and therapy group were given the same treatment two weeks later. Behavior and stroke were observed everyday; BW were weighted every week; BP were estimated every 2 weeks. Time of the first cerebral seizure of SHRsp was recorded.


RESULTS
Zhenzhu Qishi Wan had obvious preventive and therapeutic effect on genetic hypertension. The BP of prevention and therapy groups were significantly lower than that of control group (P < 0.05 [symbol: see text] P < 0.01). The drug ameliorated general behavior of SHRsp, BW of prevention group increased faster than that of control group(P < 0.05 or P < 0.01), and BW of therapy group were also heavier than that of control group at the age of 14 weeks(P < 0.05). When the experiment ended, 60% SHRsp of control group showed stroke and 20% of them were dead, while only 20% SHRsp in each of Zhenzhu Qishi Wan-treated groups showed stroke and none of them died.


CONCLUSIONS
Zhenzhu Qishi Wan had significant hypotensive effect, and some protective effect on the stroke caused by hypertension.
Du
Jun-rong
JR
Department of Pharmacology, School of Huaxi Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. dujr@mail.sc.cninfo.net
Xing
Mao
M
Lin
Zhi-rong
ZR
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000517:prevention & control; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use*; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D020521:Stroke / Q000188:drug therapy* / Q000517:prevention & control
D000959:Antihypertensive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica