title: Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography.
abstract: The steep rise in the incidence of Alzheimer's disease (AD) has further added to the considerable public health burden caused by aging of the United States population. Among the most characteristic pathologic hallmarks of AD are neuritic plaques and neurofibrillary tangles. The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD.
authors.affiliation: Laboratory of Molecular Neuropharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, 705 Parran Hall, Pittsburgh, PA 15213, USA. klunkwe@msx.upmc.edu
authors.forename: William E
authors.initials: WE
authors.lastname: Klunk
authors.forename: Henry
authors.initials: H
authors.lastname: Engler
authors.forename: Agneta
authors.initials: A
authors.lastname: Nordberg
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Bacskai
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang
authors.forename: Julie C
authors.initials: JC
authors.lastname: Price
authors.forename: Mats
authors.initials: M
authors.lastname: Bergström
authors.forename: Bradley T
authors.initials: BT
authors.lastname: Hyman
authors.forename: Bengt
authors.initials: B
authors.lastname: Långström
authors.forename: Chester A
authors.initials: CA
authors.lastname: Mathis
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed
chemical_list: D000682:Amyloid; D015415:Biomarkers