[Synthesis and properties of fluorescently-labelled triglyceride, derivative of the antineoplastic agent sarcolysin].
A new fluorescent probe, a 3-perylenoyl derivative of the lipophilized antitumor drug merphalan (sarcolysine), was synthesized. The probe is suitable for studying intracellular traffic and metabolism of merphalan and its derivatives. The perylenoyl fluorescence is partially quenched by the merphalan chromophore, which broadens the probe potentialities. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
Boldyrev
I A
IA
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997 Russia.
Grechishnikova
I V
IV
Pavlova
Iu B
IuB
Molotkovskiĭ
Iu G
IuG
D000970:Antineoplastic Agents / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D008558:Melphalan / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014280:Triglycerides / Q000138:chemical synthesis* / Q000737:chemistry
D000970:Antineoplastic Agents; D005456:Fluorescent Dyes; D014280:Triglycerides; D008558:Melphalan