Vascular microenvironment in gliomas.
Structural and functional abnormalities of the vascular microenvironment determine pathophysiological characteristics of gliomas, such as loss of blood-brain barrier function, tumor cell invasiveness, or permselectivity for large molecules. Moreover, the effectiveness of various therapeutic strategies critically depends upon the successful transvascular delivery of molecules. In order to shed more light on the vascular microenvironment in gliomas, a variety of experimental and clinical techniques have been applied to study the glioma microvasculature, including histology, vascular corrosion casts, microangiography, autoradiography, tracer washout techniques, magnetic resonance imaging, as well as intravital fluorescence microscopy. This review summarizes the characteristic features of vascular morphology, angio-architecture, tumor perfusion, microvascular permeability, and microvessel-related immunological competence in gliomas. An improved understanding of the vascular microenvironment in gliomas will help in the future to optimize glioma imaging and to improve delivery of vectors for gene therapy or encapsulated drug carriers for pharmacotherapy in patients.
Vajkoczy
Peter
P
Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, D-68167 Mannheim, Germany.
Menger
Michael D
MD
D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D005910:Glioma / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D008833:Microcirculation; D008856:Microscopy, Fluorescence; D009389:Neovascularization, Pathologic; D010477:Perfusion