title: Angiotensin-converting enzyme gene (ACE) insertion/deletion polymorphism in Mexican populations.
abstract: The angiotensin-converting enzyme gene (ACE) insertion/deletion polymorphism was determined in 211 Mexican healthy individuals belonging to different Mexican ethnic groups (98 Mestizos, 64 Teenek, and 49 Nahuas). ACE polymorphism differed among Mexicans with a high frequency of the D allele and the D/D genotype in Mexican Mestizos. The D/D genotype was absent in Teenek and present in only one Nahua individual (2.0%). When comparisons were made, we observed that Caucasian, African, and Asian populations presented the highest frequencies of the D allele, whereas Amerindian (Teenek and Pima) and Australian Aboriginals showed the highest frequencies of the I allele. The distribution of I/D genotype was heterogeneous in all populations: Australian Aboriginals presented the lowest frequency (4.9%), whereas Nahuas presented the highest (73.4%). The present study shows the frequencies of a polymorphism not analyzed previously in Mexican populations and establishes that this polymorphism distinguishes the Amerindian populations of other groups. On the other hand, since ACE alleles have been associated with genetic susceptibility to developing cardiovascular diseases and hypertension, knowledge of the distribution of these alleles could help to define the true significance of ACE polymorphism as a genetic susceptibility marker in the Amerindian populations.
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez, Tlalpan 14080, México DF, México.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Hernández-Pacheco
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Rodríguez-Pérez
authors.forename: Nonanzit
authors.initials: N
authors.lastname: Pérez-Hernández
authors.forename: Zinnia
authors.initials: Z
authors.lastname: Pavón
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.forename: Teresa
authors.initials: T
authors.lastname: Juarez-Cedillo
authors.forename: Cynthia
authors.initials: C
authors.lastname: Villarreal-Garza
authors.forename: Julio
authors.initials: J
authors.lastname: Granados
mesh_terms: D020087:Alu Elements / Q000235:genetics*; D017353:Gene Deletion; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A