Effects of an aqueous extract of Triticum repens on lipid metabolism in normal and recent-onset diabetic rats.
The aim of this study was to demonstrate the effects of single and repeated oral administration of the aqueous rhizomes extract of Triticum repens (TR) (20 mg/kg) on lipid metabolism in normal and streptozotocin-induced diabetic rats. In normal rats, the aqueous extract of TR induced a significant decrease in the plasma triglycerides concentrations 4 days (P<0.05) and 1 week after repeated oral administration (P<0.05). This reduction was abolished 2 weeks after once daily repeated oral administration. A significant decrease of plasma cholesterol levels was observed only 1 week (P<0.05) after repeated oral administration. In diabetic rats, TR treatment caused a significant decrease in plasma triglycerides levels after a single (P<0.01) and repeated (P<0.001) oral administration. A strong decrease in cholesterol level was observed 6 h after a single oral administration of the aqueous extract TR (P<0.001). Four days after repeated oral administration of TR aqueous extract, the plasma cholesterol level was significantly decreased (P<0.05) and still dropped after 2 weeks (P<0.001). On other hand, the repeated oral administration of aqueous TR extract caused a significant decrease in body weight 2 weeks after repeated oral treatment in diabetic rats (P<0.05). We conclude that the aqueous extract of TR exhibits lipid and body weight lowering activities in severe hyperglycaemic rats after repeated oral administration of aqueous TR extract at a dose of 20 mg/kg.
Maghrani
M
M
UFR PNPE, BP 21, Errachidia, Morocco.
Lemhadri
A
A
Zeggwagh
N-A
NA
El Amraoui
M
M
Haloui
M
M
Jouad
H
H
Eddouks
M
M
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome; D014280:Triglycerides / Q000097:blood*; D014908:Triticum; D014867:Water / Q000494:pharmacology
D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D014867:Water; D002784:Cholesterol