title: Ethanol-induced decrease of the expression of glucose transport protein (Glut3) in the central nervous system as a predisposing condition to apoptosis: the effect of age.
abstract: We measured the effect of chronic ethanol administration on the expression of Glut3 in the cerebellum and hippocampus of adult and old rats. Glut3 expression significantly decreased in aging, in ethanol-treated rats vs. age-matched controls, and in adult- vs. old ethanol-treated rats. These findings lend consistent support to the hypothesis that disturbances of glucose metabolism due to ethanol may constitute an unfavorable condition predisposing to neuronal death.
authors.affiliation: Neurobiology of Aging Laboratory, N. Masera INRCA Research Department, 60121 Ancona, Italy. p.fattoretti@inrca.it
authors.forename: P
authors.initials: P
authors.lastname: Fattoretti
authors.forename: C
authors.initials: C
authors.lastname: Bertoni-Freddari
authors.forename: T
authors.initials: T
authors.lastname: Casoli
authors.forename: G
authors.initials: G
authors.lastname: Di Stefano
authors.forename: G
authors.initials: G
authors.lastname: Giorgetti
authors.forename: M
authors.initials: M
authors.lastname: Solazzi
mesh_terms: D000375:Aging; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002531:Cerebellum / Q000254:growth & development / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology*; D051274:Glucose Transporter Type 3; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology*; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D051381:Rats
chemical_list: D051274:Glucose Transporter Type 3; D009004:Monosaccharide Transport Proteins; D009419:Nerve Tissue Proteins; C495690:Slc2a3 protein, rat; D000431:Ethanol