Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea.
The phytochemicals betulinic acid (1), wogonin (2) and oroxindin (3) isolated from the aerial parts of Bacopa monnieri and Holmskioldia sanguinea showed significant antifungal activity against the two fungi Alternaria alternata and Fusarium fusiformis. Inhibition of root growth germination of wheat seeds was observed for all three compounds which showed 100% inhibition at 10 micro g/mL. Compounds (1) and (2) showed potent inhibition of Alternaria alternata compared with oroxindin at a concentration of 4 micro g/mL, whereas compound (2) was an effective inhibitor of both fungi. The structures of the compounds were established by spectral and chemical studies.
Chaudhuri
P K
PK
Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow 226 015, India.
Srivastava
Rashmi
R
Kumar
Sunil
S
Kumar
Sushil
S
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D034681:Bacopa; D002867:Chromones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D044950:Flavanones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005965:Glucuronates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D053978:Pentacyclic Triterpenes; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots / Q000187:drug effects; D012639:Seeds / Q000187:drug effects; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D029648:Verbenaceae; D000094062:Betulinic Acid
D000935:Antifungal Agents; D002867:Chromones; D044950:Flavanones; D005965:Glucuronates; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D014315:Triterpenes; C484966:oroxindin; C085514:wogonin; D000094062:Betulinic Acid