Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727.
In actinomycetes the catabolism products of branched chain amino acids provide biosynthetic precursors for the formation of several lipid-containing antibiotics. We have determined in Nonomuraea sp. ATCC 39727 the effect of valine on production of glycopeptide antibiotic A40926, which is a complex of factors structurally differing in fatty acid moieties. Addition of valine to minimal medium increased A40926 production and modified complex composition towards a mono-component. Similar results were also obtained in a rich production medium.
Beltrametti
Fabrizio
F
Vicuron Pharmaceuticals Italy S.r.l., Via R. Lepetit, 34, 21040, Gerenzano (Varese) Italy. fbeltrametti@ricuron.it
Jovetic
Srdjan
S
Feroggio
Marina
M
Gastaldo
Luciano
L
Selva
Enrico
E
Marinelli
Flavia
F
D039903:Actinobacteria / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids / Q000378:metabolism; D005285:Fermentation; D006020:Glycopeptides; D015394:Molecular Structure; D017334:Teicoplanin / Q000031:analogs & derivatives; D014633:Valine / Q000378:metabolism*
C054981:A 40926; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D006020:Glycopeptides; D017334:Teicoplanin; D014633:Valine