Use of cystatin C determination in clinical diagnostics.
This paper presents a current view of the possible clinical uses of cystatin C determination. Cystatin C is an inhibitor of cysteine proteases, and relatively stable in the systemic circulation it is comparatively easily determined. Although in clinical practice it is known primarily as a relatively reliable and endogenous marker for glomerular filtration, lately cystatin C analysis has been discussed in connection with the diagnostics of a variety of diseases such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases.
Mares
Jan
J
Clinic of Neurology, Teaching Hospital, Olomouc, Czech Republic.
Stejskal
David
D
Vavrousková
Jitka
J
Urbánek
Karel
K
Herzig
Roman
R
Hlustík
Petr
P
D000544:Alzheimer Disease / Q000175:diagnosis; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling; D002493:Central Nervous System Diseases / Q000175:diagnosis; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis*; D006801:Humans
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins