title: Specific tyrosine phosphorylation in response to bile in Fasciola hepatica and Echinostoma friedi.
abstract: Protein tyrosine phosphorylation (PY) is a well-known signalling mechanism which is also involved in host-parasite interactions. Despite its transcendence, PY has been poorly studied in parasitic helminths. The aim of this study is to examine the effect of bile salts on the PY pattern in parasitic trematodes. Two distinct adult models were analysed: Echinostoma friedi, of intestinal habitat, and Fasciola hepatica, naturally inhabitant of host biliary channels. Our results show that bile salts induce specific and distinct protein PY in both trematode species, indicating that this signalling process seems to be also involved in host-trematode relationships.
authors.affiliation: Departamento de Parasitología y Biología Celular, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain. antonio.marcilla@uv.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Marcilla
authors.forename: José Enrique De la
authors.initials: JE
authors.lastname: Rubia
authors.forename: Ana
authors.initials: A
authors.lastname: Espert
authors.forename: Inés
authors.initials: I
authors.lastname: Carpena
authors.forename: José Guillermo
authors.initials: JG
authors.lastname: Esteban
authors.forename: Rafael
authors.initials: R
authors.lastname: Toledo
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D002417:Cattle; D006224:Cricetinae; D004449:Echinostoma / Q000187:drug effects / Q000378:metabolism*; D005210:Fasciola hepatica / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D001647:Bile Acids and Salts; D014443:Tyrosine