[Autologous stem cell transplantation in addition to cardiomyoplasty in a porcine model of ischemic cardiomyopathy].
Autologuous stem cell transplantation within regional infarcted or ischemic myocardium is currently a focus of experimental research world-wide, and could provide a unique way to ensure myocardial functional recovery. In order to benefit from immediate access to bone marrow stromal cells at the time of myocardial injury, and thus avoid the delay rendered necessary by autologuous harvesting and clonal expansion, the use of allogeneic stem cell could be of major interest. This experimental work is based on a unique mini-swine model in which the histocompatibility antigens are known, and perfectly controlled, through inbreeding and investigate the survival and the induction of an immune tolerance to allogeneic stem cells injected into the infarcted myocardium with the use of transient immunosuppression (12 days).
Poncelet
A
A
Laboratoire de Chimie expérimentale, CHEX, U.C.L.
Gianello
P
P
D000818:Animals; D018421:Cardiomyoplasty; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D007165:Immunosuppression Therapy / Q000379:methods; D009203:Myocardial Infarction / Q000628:therapy*; D033581:Stem Cell Transplantation; D013552:Swine; D013556:Swine, Miniature