title: Neoplastic transformation and tumour-like lesions in Paget's disease of bone: a pictorial review.
abstract: The development of a sarcoma is the most serious complication of Paget's disease of bone. Although its incidence is <1% of those with the underlying disease, it is important to recognise the imaging features of these tumours as Paget's disease of bone is relatively common in the ageing population in certain parts of the world. The purpose of this pictorial review is to present the imaging features of Paget's sarcoma based on one orthopaedic oncology centres experience in 49 patients; however, not all masses or destructive lesions arising in association with Paget's disease are sarcomas and not all the tumours are malignant. This review also includes other malignancies which may arise in pagetic bone as well as tumour-like manifestations of Paget's disease.
authors.affiliation: Department of Radiology, Royal Orthopaedic Hospital, Birmingham, B31 2AP, UK.
authors.forename: C
authors.initials: C
authors.lastname: López
authors.forename: D V
authors.initials: DV
authors.lastname: Thomas
authors.forename: A M
authors.initials: AM
authors.lastname: Davies
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000000981:diagnostic imaging* / Q000473:pathology*; D011379:Prognosis; D018570:Risk Assessment; D012509:Sarcoma / Q000473:pathology*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods