Single blastocyst transfer: a prospective randomized trial.
OBJECTIVE
To determine the efficacy of single blastocyst transfer.


METHODS
Prospective randomized trial.


METHODS
Private assisted reproductive technology unit.


METHODS
Forty-eight women undergoing IVF-embryo transfer with day 3 FSH <or=10 mIU/mL and at least 10 follicles >12 mm in diameter on day of hCG administration.


METHODS
Embryo culture to the blastocyst stage in sequential media G1/G2 followed by transfer of either one or two blastocysts.


METHODS
Implantation rate, ongoing pregnancy rate, and twinning.


RESULTS
The transfer of a single blastocyst resulted in an implantation and ongoing pregnancy rate of 60.9% with no twins. The transfer of two blastocysts resulted in an implantation rate of 56%, an ongoing pregnancy rate of 76% with a 47.4% incidence of twins.


CONCLUSIONS
Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.
Gardner
David K
DK
Colorado Center for Reproductive Medicine, Englewood, Colorado 80110, USA. dgardner@colocrm.com
Surrey
Eric
E
Minjarez
Debra
D
Leitz
Annette
A
Stevens
John
J
Schoolcraft
William B
WB
D000328:Adult; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple / Q000706:statistics & numerical data; D016896:Treatment Outcome; D014427:Twins / Q000706:statistics & numerical data