title: Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727.
abstract: In actinomycetes the catabolism products of branched chain amino acids provide biosynthetic precursors for the formation of several lipid-containing antibiotics. We have determined in Nonomuraea sp. ATCC 39727 the effect of valine on production of glycopeptide antibiotic A40926, which is a complex of factors structurally differing in fatty acid moieties. Addition of valine to minimal medium increased A40926 production and modified complex composition towards a mono-component. Similar results were also obtained in a rich production medium.
authors.affiliation: Vicuron Pharmaceuticals Italy S.r.l., Via R. Lepetit, 34, 21040, Gerenzano (Varese) Italy. fbeltrametti@ricuron.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Beltrametti
authors.forename: Srdjan
authors.initials: S
authors.lastname: Jovetic
authors.forename: Marina
authors.initials: M
authors.lastname: Feroggio
authors.forename: Luciano
authors.initials: L
authors.lastname: Gastaldo
authors.forename: Enrico
authors.initials: E
authors.lastname: Selva
authors.forename: Flavia
authors.initials: F
authors.lastname: Marinelli
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005227:Fatty Acids / Q000378:metabolism; D005285:Fermentation; D006020:Glycopeptides; D015394:Molecular Structure; D017334:Teicoplanin / Q000031:analogs & derivatives; D014633:Valine / Q000378:metabolism*
chemical_list: C054981:A 40926; D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D006020:Glycopeptides; D017334:Teicoplanin; D014633:Valine