title: Morphometry of medial gaps of human brain artery branches.
abstract: OBJECTIVE
  The bifurcation regions of the major human cerebral arteries are vulnerable to the formation of saccular aneurysms. A consistent feature of these bifurcations is a discontinuity of the tunica media at the apex of the flow divider. The objective was to measure the 3-dimensional geometry of these medial gaps or "medial defects."
  
  
  METHODS
  Nineteen bifurcations and 2 junctions of human cerebral arteries branches (from 4 male and 2 female subjects) were formalin-fixed at physiological pressure and processed for longitudinal serial sectioning. The apex and adjacent regions were examined and measurements were made from high-magnification photomicrographs, or projection microscope images, of the gap dimensions at multiple levels through the bifurcation.
  
  
  RESULTS
  Plots were made of the width of the media as a function of distance from the apex. The media at each edge of the medial gap widened over a short distance, reaching the full width of the media of the contiguous daughter vessel. Medial gap dimensions were compared with the planar angle of the bifurcation, and a strong negative correlation was found, ie, the acute angled branches have the more prominent medial gaps.
  
  
  CONCLUSIONS
  A discontinuity of the media at the apex was seen in all the bifurcations examined and was also found in the junction regions of brain arteries. We determined that the gap width is continuous with well-defined dimensions throughout its length and average length-to-width ratio of 6.9. The gaps were generally centered on the prominence of the apical ridge.
authors.affiliation: Department of Medical Biophysics, Faculty of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada, N6A 5C1. pcanham@uwo.ca
authors.forename: Peter B
authors.initials: PB
authors.lastname: Canham
authors.forename: Helen M
authors.initials: HM
authors.lastname: Finlay
mesh_terms: D000368:Aged; D001921:Brain / Q000098:blood supply; D002536:Cerebral Arteries / Q000033:anatomy & histology*; D002941:Circle of Willis / Q000033:anatomy & histology; D004730:Endothelium, Vascular / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008953:Models, Anatomic; D009131:Muscle, Smooth, Vascular / Q000033:anatomy & histology; D017540:Tunica Media / Q000033:anatomy & histology*