title: [Reflux esophagitis after H. pylori eradication].
abstract: We have reported that prevalence of H. pylori infection and grade of atrophic gastritis were significantly lower, while acid secretion was significantly greater in the patients with reflux esophagitis than those without it. We have also reported that increased gastric acid secretion after H. pylori eradication may explain a reason for developing reflux esophagitis. Therefore, H. pylori is considered to be a protective factor for the development of reflux esophagitis via the induction of gastric hyposecretion. Conversely, according to recent large population-based studies, no evidence was obtained that supports the increased frequency of heartburn symptoms or reflux oesophagitis after the eradication of H. pylori. One reason for the discrepancy may be the difference in the evaluation of gastro-esophageal reflux, another reason may be the difference in acid secretion before the clearance of H. pylori in individual subjects, because the effects of H. pylori on acid secretion vary from patient to patient.
authors.affiliation: Division of Gastroenterology, Tohoku University Graduate School of Medicine.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Koike
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ohara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sekine
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iijima
authors.forename: Ken
authors.initials: K
authors.lastname: Ariizumi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Inomata
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: Naohiro
authors.initials: N
authors.lastname: Dairaku
authors.forename: Akira
authors.initials: A
authors.lastname: Imatani
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Kato
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D004942:Esophagitis, Peptic / Q000209:etiology*; D005744:Gastric Acid / Q000378:metabolism; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000503:physiopathology; D016480:Helicobacter pylori; D006801:Humans