Sex difference in the effect of ACE-DD genotype on the risk of premature myocardial infarction.
In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.
Petrovic
Daniel
D
Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia. daniel.petrovic@mf.uni-lj.si
Bregar
Dejan
D
Guzic-Salobir
Barbara
B
Skof
Erik
E
Span
Matjaz
M
Terzić
Rifet
R
Petrovic
Mojca Globocnik
MG
Keber
Irena
I
Letonja
Mitja
M
Zorc
Marjeta
M
Podbregar
Matej
M
Peterlin
Borut
B
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
D007703:Peptidyl-Dipeptidase A