Porphyromonas gingivalis-specific immunoglobulin G prevents P. gingivalis-elicited oral bone loss in a murine model.
Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance of P. gingivalis in a subcutaneous chamber model and prevents P. gingivalis-elicited oral bone loss.
Gibson
Frank C
FC
Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Massachusetts 02118, USA.
Gonzalez
Dario A
DA
Wong
Jodie
J
Genco
Caroline Attardo
CA
D016301:Alveolar Bone Loss / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016866:Bacteroidaceae Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D004195:Disease Models, Animal; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009055:Mouth; D010518:Periodontitis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D016966:Porphyromonas gingivalis / Q000276:immunology* / Q000472:pathogenicity
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G