title: Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation.
abstract: Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.
authors.affiliation: Department of Radiology, Oncology and Clinical Immunology, Division of Clinical Immunology, The Rudbeck Laboratory, University Hospital, Uppsala, Sweden.
authors.forename: Kristina N
authors.initials: KN
authors.lastname: Ekdahl
authors.forename: Anders A
authors.initials: AA
authors.lastname: Bengtsson
authors.forename: Jonas
authors.initials: J
authors.lastname: Andersson
authors.forename: Graciela
authors.initials: G
authors.lastname: Elgue
authors.forename: Lars
authors.initials: L
authors.lastname: Rönnblom
authors.forename: Gunnar
authors.initials: G
authors.lastname: Sturfelt
authors.forename: Bo
authors.initials: B
authors.lastname: Nilsson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000991:Antithrombins / Q000378:metabolism; D005172:Factor XI / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D015539:Platelet Activation; D013927:Thrombosis / Q000097:blood / Q000209:etiology*; D020246:Venous Thrombosis / Q000097:blood; D001620:beta-Thromboglobulin / Q000378:metabolism
chemical_list: D000991:Antithrombins; D001620:beta-Thromboglobulin; D005340:Fibrinogen; D005172:Factor XI