Crystal structure of the supramolecular linear polymer formed by the self-assembly of mono-6-deoxy-6-adamantylamide-beta-cyclodextrin.
Mono-6-deoxy-6-adamantylamide-beta-cyclodextrin-dimethylformamide-15H2O, C53H85NO35.C3H7NO.15H2O, crystallizes in the orthorhombic space group P2(1)2(1)2(1). The adamantyl group is inserted into the cyclodextrin cavity of the adjacent molecule, entering by the side of the secondary hydroxy rim, thus forming a supramolecular linear polymer by self-assembly. Adjacent macrocycles are linked into columns by hydrogen bonds involving the nearest glucose residues, and the structure is further stabilized by their involvement in hydrogen bonding with water molecules which reside in channels surrounding the polymer columns, thus acting as bridges between the cyclodextrin units. The centroid of the adamantyl group lies below the plane formed by the seven glycosidic O atoms of the host cyclodextrin, excluding water molecules from the secondary side of beta-cyclodextrin (beta-CD). Between the adamantyl group and the primary hydroxy rim of the cyclodextrin cavity lies a dimethylformamide molecule, which shields the hydrophobic adamantyl group from the primary hydroxy rim of its carrying beta-CD and excludes water molecules from the primary side of the beta-CD cavity.
Tellini
Victor Hugo Soto
VH
Departamento de Química Física, Facultad de Ciencias, Universidad de Santiago de Compostela, Avda. Alfonso X El Sabio s/n, 27002 Lugo, Spain.
Jover
Aida
A
Galantini
Luciano
L
Meijide
Francisco
F
Tato
José Vázquez
JV
D000547:Amantadine / Q000031:analogs & derivatives* / Q000737:chemistry; D018360:Crystallography, X-Ray; D005947:Glucose / Q000737:chemistry; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
D011108:Polymers; D047392:beta-Cyclodextrins; D014867:Water; D000547:Amantadine; D005947:Glucose