[Effect of daidzein on antiarrhythmia].
OBJECTIVE
To study the effect of Daidzein on Antiarrhythmia.


METHODS
The conventional antiarrhythmia methods were used.


RESULTS
Daidzein was remarkedly effective in preventing ventricular fibrillation induced by chloroform in mice and arrhythmia induced by aconitine in rats. The arrhythmia induced by adrenalin in rabbits was antagonized by Daidzein and it could obviously inhibit the action potential amplitude of isolated sciatic nerves in toads. And it could also prevent ventricular fibrillation induced by calcium chloride in rats, and obviously reduce the death rate of rats. Its anti-arrhythmic effect was dose-dependent.


CONCLUSIONS
Daidzein has obvious protective effect on drug-induced arrhythmia, which may be related to its inhibition of Na+ or Ca2+ influx and its blocking beta-adrenergic receptor.
Ye
He-Yang
HY
Department of Pharmacology, Gan Nan Medical College, Ganzhou 341000, Jiangxi, China. heyangye@sohu.com
Qiu
Feng
F
Zeng
Jing
J
Yiao
Xing-sen
XS
Lai
Fei
F
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D002023:Bufo bufo; D002122:Calcium Chloride; D002725:Chloroform; D004837:Epinephrine; D005260:Female; D066298:In Vitro Techniques; D007529:Isoflavones / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D029908:Pueraria / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000517:prevention & control*
D000889:Anti-Arrhythmia Agents; D007529:Isoflavones; C004742:daidzein; D002725:Chloroform; D002122:Calcium Chloride; D000157:Aconitine; D004837:Epinephrine