Cranial nerve palsies in metastatic prostate cancer--results of base of skull radiotherapy.
We studied the rate of response to palliative external beam radiation therapy (20 Gy/5 or 30 Gy/10 fractions) to the base of skull in 32 prostate cancer patients with cranial nerve dysfunction. Sixteen patients (50%; 95% CI, 34-66%) had a useful response to therapy. The median survival post-therapy was 3 months.
O'Sullivan
Joe M
JM
Academic Unit of Radiotherapy and Clinical Oncology, Institute of Cancer Research/Royal Marsden Hospital, Sutton, Surrey SM2 5PT, UK.
Norman
Andrew R
AR
McNair
Helen
H
Dearnaley
David P
DP
D000368:Aged; D003389:Cranial Nerve Diseases / Q000188:drug therapy / Q000209:etiology*; D003907:Dexamethasone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology*; D011829:Radiation Dosage; D019292:Skull Base Neoplasms / Q000150:complications / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D016896:Treatment Outcome
D005938:Glucocorticoids; D003907:Dexamethasone