Lipopolysaccharide retards development of amygdala kindling but does not affect fully-kindled seizures in rats.
Seizures are common sequel to brain insults in cases such as stroke, trauma and infection where there is a certain neuroinflammation. Intracerebroventricular (i.c.v.) administration of lipopolysaccharide (LPS) induces an inflammatory state in brain that is used as a model of neuroinflammation. We studied the effect of LPS (0.25 and 2.5 microg/rat, i.c.v.) on development of electrical kindling of the amygdala and on fully-kindled seizures. LPS, at the doses used, had no effect on fully-kindled seizures and afterdischarge (AD) duration at 0.5, 2 or 4h after administration. However, daily injection of LPS (2.5 microg/rat) retarded acquisition of kindled behavioral seizures. This antiepileptogenic effect could be due to the release of inflammatory mediators from microglia and the related morphological and functional changes in synaptic neurotransmission.
Sayyah
Mohammad
M
Department of Physiology and Pharmacology, Institute Pasteur of Iran, Pasteur Avenue, Tehran 13164, Iran. sayyah@institute.pasteur.ac.ir
Najafabadi
Iraj Toubeihaye
IT
Beheshti
Siamak
S
Majzoob
Sayeh
S
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008070:Lipopolysaccharides / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*
D008070:Lipopolysaccharides