The effects of selective serotonin-reuptake inhibitor on visual evoked potential in rats.
The present study was undertaken to clarify the effects of selective serotonin-reuptake inhibitors (SSRIs) on visual evoked potential (VEP) in rats. To elucidate the mechanism of action of SSRIs, some serotonin (5-HT) agonists were used. SSRIs, fluvoxamine and paroxetine, caused a reduction in the amplitudes of P1-N1, P3-N3, and N3-P4 components of VEP. The amplitude of the P1-N1 component was also reduced by the 5-HT1A agonist 8-OH-DPAT and 5-HT1B agonist anpirtoline. On the other hand, amplitudes of P3-N3 and N3-P4 components were reduced by anpirtoline and the 5-HT2 agonist DOI. These results indicate that the reduction in the amplitude of the P1-N1 component of VEP induced by SSRIs may participate in 5-HT1A and 5-HT1B receptors, and those of P3-N3 and N3-P4 components induced by SSRIs may be closely related with 5-HT1B and 5-HT2 receptors.
Iwamura
Yoshihiro
Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Fujii
Yoko
Y
Kamei
Chiaki
C
D000284:Administration, Oral; D000818:Animals; D003626:Data Display; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D016666:Fluvoxamine / Q000008:administration & dosage / Q000493:pharmacokinetics; D008297:Male; D009778:Occipital Lobe / Q000502:physiology; D009991:Oscillometry / Q000295:instrumentation; D017374:Paroxetine / Q000008:administration & dosage / Q000493:pharmacokinetics; D010775:Photic Stimulation / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013238:Stereotaxic Techniques / Q000295:instrumentation
D016666:Fluvoxamine; D017374:Paroxetine; D011985:Receptors, Serotonin; D017367:Selective Serotonin Reuptake Inhibitors