title: [Studies on stability of chlorogenic acid in extract of Flos lonicerae].
abstract: OBJECTIVE
  To investigate the stability of chlorogenic acid in extract of flos lonicerae in different conditions.
  
  
  METHODS
  The stability of chlorogenic acid in extract of flos lonicerae in phosptat buffe with different pH values, methanol, ethanol and different base solutions(Ca(OH)2 and NaOH) was investigated by the classical isothermal method.
  
  
  RESULTS
  The experiments showed the chlorogenic acid in extract of flos lonicerae was more stable in acidic water than in basic water. It was stable in these organic solutions and base solution[Ca(OH)2].
  
  
  CONCLUSIONS
  In different conditions, the stability of chlorogenic acid in extract of flos lonicerae was different. It provided a reference to the extraction and analysis of chlorogenic acid and production of chlorogenic acid preparation.
authors.affiliation: Pharmaceutical Laboratory of Chinese Materia Medica, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Shi-xiang
authors.initials: SX
authors.lastname: Hou
authors.forename: Ping
authors.initials: P
authors.lastname: Hu
authors.forename: Ning
authors.initials: N
authors.lastname: He
authors.forename: Ya-ning
authors.initials: YN
authors.lastname: Zhu
authors.forename: Lun
authors.initials: L
authors.lastname: Cao
mesh_terms: D002126:Calcium Hydroxide; D002726:Chlorogenic Acid / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D035264:Flowers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D031239:Lonicera / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012972:Sodium Hydroxide; D012996:Solutions; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D012996:Solutions; D002726:Chlorogenic Acid; D012972:Sodium Hydroxide; D002126:Calcium Hydroxide