Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.
Ca(2+) is a major trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular smooth muscle cell proliferation. The transient receptor potential cation channels participate in regulating intracellular Ca(2+) and thus vascular contractility and cell proliferation. Upregulation of genes encoding these channels is involved in the development of pulmonary hypertension.
Landsberg
Judd W
JW
Department of Medicine, School of Medicine, University of California, San Diego, California 92103, USA.
Yuan
Jason X-J
JX
D000818:Animals; D015220:Calcium Channels / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology / Q000503:physiopathology*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D011651:Pulmonary Artery / Q000166:cytology*; D050052:TRPC Cation Channels
D015220:Calcium Channels; D050052:TRPC Cation Channels