A molecular explanation of interactions between photic and non-photic circadian clock-resetting stimuli.
Non-photic clock-resetting events (arousal and locomotor activity) in the subjective day reduced expression of Period genes in the suprachiasmatic nucleus of hamsters. This decrease was attenuated by a 30-min light pulse occurring during the last 0.5 h of 3.5 h of confinement to a novel running wheel. This provides an example at the molecular level of an interaction between different modalities of synchronizing agents.
Maywood
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Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK.
Mrosovsky
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