title: Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy.
abstract: We present a case report of a 10 years old boy with protein-losing enteropathy and eosinophilic gastroenteritis who had positive histamine release tests, increased allergen-specific IgE antibodies to some food items, and low levels of total serum protein and albumin. Upper gastrointestinal endoscopy revealed a number of polyps and diffuse gastritis. Biopsy specimens of the stomach and duodenum showed widespread eosinophilia and neutrophilia. Although a restricted diet was recommended, a diet which excluded foods with positive results to both histamine release test and allergen-specific IgE antibodies was poorly tolerated, and the patient rejected systemic administration of corticosteroids. Thus, we initiated an oral disodium cromoglycate (DSCG) and ketotifen therapy. After oral DSCG and ketotifen administration, the patient's condition improved gradually. Therefore, oral DSCG and ketotifen therapy might be considered as treatment option in patients with eosinophilic gastroenteritis and protein-losing enteropathy caused by food allergy.
authors.affiliation: Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.
authors.forename: Junzo
authors.initials: J
authors.lastname: Suzuki
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Ruriko
authors.initials: R
authors.lastname: Nozawa
authors.forename: Masato
authors.initials: M
authors.lastname: Isome
authors.forename: Shigeo
authors.initials: S
authors.lastname: Suzuki
authors.forename: Ai
authors.initials: A
authors.lastname: Takahashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000284:Administration, Oral; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D000918:Antibody Specificity / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002648:Child; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D016099:Endoscopy, Gastrointestinal; D047091:Eosinophil Granule Proteins / Q000097:blood; D004802:Eosinophilia / Q000175:diagnosis* / Q000188:drug therapy*; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000188:drug therapy*; D005759:Gastroenteritis / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D011504:Protein-Losing Enteropathies / Q000175:diagnosis* / Q000188:drug therapy*; D011852:Radioallergosorbent Test
chemical_list: D018927:Anti-Asthmatic Agents; D015415:Biomarkers; D047091:Eosinophil Granule Proteins; D007073:Immunoglobulin E; D004205:Cromolyn Sodium