title: Quantitative assessment of parenchymal and ventricular readjustment to intracranial pressure relief.
abstract: A 26-year-old patient underwent endoscopic third ventriculostomy for the treatment of obstructive hydrocephalus. 3D volume data sets were obtained at 3 T before surgery and three times after surgery. Off-line analysis of individual imaging data (initial linear registration, intensity adjustment, and final nonlinear registration of pre- to postoperative MR images) yielded 3D displacement fields representing the postoperative structural brain change. In principle, such an analysis technique can be used in any clinical follow-up for which careful observation of tissue readjustment is of particular importance.
authors.affiliation: Max-Planck-Institute of Human Cognitive and Brain Science, Stephenstrasse 1a, 04103 Leipzig, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Preul
authors.forename: Marc
authors.initials: M
authors.lastname: Tittgemeyer
authors.forename: Dirk
authors.initials: D
authors.lastname: Lindner
authors.forename: Christos
authors.initials: C
authors.lastname: Trantakis
authors.forename: Jürgen
authors.initials: J
authors.lastname: Meixensberger
mesh_terms: D000328:Adult; D002552:Cerebral Ventricles / Q000473:pathology*; D004724:Endoscopy; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis / Q000601:surgery*; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D017711:Nonlinear Dynamics; D011183:Postoperative Complications / Q000175:diagnosis*; D011379:Prognosis; D012680:Sensitivity and Specificity; D014696:Ventriculostomy