title: Prevalence of troponin-T elevation during out-of-hospital cardiac arrest.
abstract: To determine the prevalence of myocardial ischemia before out-of-hospital cardiac arrest (OOHCA), we determined the prevalence of elevated cardiac troponin-T levels in subjects at the time of OOHCA. Plasma was collected from 63 subjects during resuscitation. Troponin levels were elevated (> or =0.03 ng/ml) in 25 subjects (39.7%; 95% confidence intervals [CI] 29% to 52%). Increasing age was associated with elevated troponin (OR 1.10; 95% CI 1.04 to 1.17). Elevated troponin levels did not reliably predict short-term outcome. Because troponin increases hours after the onset of ischemia, these data reveal that about 40% of OOHCA cases can undergo intervention before collapse.
authors.affiliation: Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Lai
authors.forename: David
authors.initials: D
authors.lastname: Hostler
authors.forename: Brian J
authors.initials: BJ
authors.lastname: D'Cruz
authors.forename: Clifton W
authors.initials: CW
authors.lastname: Callaway
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000453:epidemiology* / Q000209:etiology; D010414:Pennsylvania / Q000453:epidemiology; D011237:Predictive Value of Tests; D015995:Prevalence; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T