title: In vivo and in vitro effects of different anaesthetics on platelet function.
abstract: Different effects of thiopental, propofol and sevoflurane on platelets have been reported. Patients undergoing thyroid surgery were anaesthetized with thiopental-fentanyl-sevoflurane (n = 11) or propofol-fentanyl-sevoflurane (n = 9). Platelet aggregation and thromboxane A2 generation were studied at baseline, and at the end of anaesthesia induction and surgery. Dose-response experiments were also performed in vitro with single agents. Thiopental-fentanyl-sevoflurane significantly reduced collagen-induced aggregation by the end of induction, while ADP-induced aggregation and thromboxane generation were unaffected. Propofol-fentanyl-sevoflurane had no effect on platelets. Thiopental dose-dependently inhibited platelets in vitro, while fentanyl or propofol did not. In conclusion, thiopental reduces platelet function both ex vivo and in vitro and propofol might be considered haemostatically safer.
authors.affiliation: Department of Anaesthesiology, Catholic University School of Medicine, Rome Research Center on Pathophysiology of Haemostasis, Catholic University School of Medicine, Rome, Italy.
authors.forename: Pier Lorenza
authors.initials: PL
authors.lastname: Dordoni
authors.forename: Luciano
authors.initials: L
authors.lastname: Frassanito
authors.forename: Maria F
authors.initials: MF
authors.lastname: Bruno
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Proietti
authors.forename: Raimondo
authors.initials: R
authors.lastname: de Cristofaro
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ciabattoni
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Ardito
authors.forename: Roberto
authors.initials: R
authors.lastname: Crocchiolo
authors.forename: Raffaele
authors.initials: R
authors.lastname: Landolfi
authors.forename: Bianca
authors.initials: B
authors.lastname: Rocca
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019162:Anesthetics, Combined / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D011184:Postoperative Period; D015742:Propofol / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology; D013928:Thromboxane A2 / Q000096:biosynthesis
chemical_list: D019162:Anesthetics, Combined; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D013928:Thromboxane A2; D013874:Thiopental; D015742:Propofol