title: Imprint cytology of the sentinel lymph node in the assessment of axillary node status in breast carcinoma.
abstract: BACKGROUND
  Intra-operative assessment of the sentinel lymph node (SLN) status may allow the surgeon to complete the breast cancer surgery in most patients in one sitting. We have studied the role of imprint cytology in the assessment of SLN status.
  
  
  METHODS
  Imprint cytology of the SLN in 132 patients with invasive breast carcinoma was correlated with the histopathological assessment of the SLN and overall axillary nodal status. In 26 patients, the cytology was reported intra-operatively.
  
  
  RESULTS
  Imprint cytology reflected the status of the parent node well (sensitivity 86%, specificity 97%, positive predictive value (PPV) 92%, negative predictive value (NPV) 93%). Its ability to reflect the axillary status was also good (sensitivity 70%, specificity 97%, PPV 95% and NPV 83%) but somewhat diminished by the relatively high number of false-negative SLN in the study. Intra-operative assessment (sensitivity 86%, specificity 100%, PPV 100% and NPV 95%) did not reduce the accuracy of imprint cytology in predicting the SLN status and took a mean of 24.5 min.
  
  
  CONCLUSIONS
  Imprint cytology is an accurate and relatively simple method for the assessment of the SLN and can be a useful intra-operative tool.
authors.affiliation: Breast Unit, Luton and Dunstable Hospital, Luton LU4 0DZ, UK.
authors.forename: D
authors.initials: D
authors.lastname: Ravichandran
authors.forename: G
authors.initials: G
authors.lastname: Kocjan
authors.forename: M
authors.initials: M
authors.lastname: Falzon
authors.forename: R Y
authors.initials: RY
authors.lastname: Ball
authors.forename: D N L
authors.initials: DN
authors.lastname: Ralphs
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology*; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*