Analysis of menstrual, reproductive, and life-style factors for breast cancer risk in Turkish women: a case-control study.
The aim of this study was to investigate the association between menstrual, reproductive, and life-style factors and breast cancer in Turkish women. In a hospital-based case-control study in Ankara, 622 patients with histologically confirmed breast cancer were compared with 622 age-matched controls, admitted to the same hospital for acute and non-neoplastic diseases. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) related to risk factors. Overall, menopausal status and age at menopause were found to be significantly associated with breast cancer. Having a full-term pregnancy and early age at first birth were associated with decreased breast cancer risk (OR = 0.45, 95% CI = 0.30-0.66; OR = 0.34, 95% CI = 0.22-0.53, respectively). Postmenopausal women with lactation longer than 48 mo had reduced risk of breast cancer (OR = 0.36, 95% CI = 0.14-0.93). In conclusion, decreased parity, late age at first birth, early menopause, and shorter duration of lactation were the most important determinants of breast cancer risk in Turkish women.
Oran
Betul
B
Department of Medical Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey. betul.oran@bmc.org
Celik
Ismail
I
Erman
Mustafa
M
Baltali
Esmen
E
Zengin
Nurullah
N
Demirkazik
Figen
F
Tezcan
Sabahat
S
D000367:Age Factors; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007774:Lactation; D008019:Life Style; D016015:Logistic Models; D017533:Marital Status; D008597:Menstrual Cycle / Q000502:physiology*; D015999:Multivariate Analysis; D016017:Odds Ratio; D012098:Reproduction / Q000502:physiology; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology