Salmonella redirects phagosomal maturation.
Following invasion of host cells, Salmonella occupies an intracellular vacuole that superficially resembles a phagosome. However, unlike bona fide phagosomes that undergo a maturation process to become microbicidal phago-lysosomes, Salmonella avoid killing by arresting and diverting the maturation program of the invasion vacuole. As a result of this re-routing, the bacteria generate a protected niche where they survive and replicate.
Brumell
John H
JH
Infection, Immunity, Injury and Repair Program, The Hospital for Sick Children, 555 University Ave., Toronto, Ontario, M5G 1X8, Canada. john.brunell@sickkids.ca
Grinstein
Sergio
S
D000818:Animals; D006801:Humans; D010588:Phagosomes / Q000276:immunology*; D012475:Salmonella / Q000276:immunology*; D012480:Salmonella Infections / Q000276:immunology* / Q000382:microbiology*