title: Comparison of tacrolimus and cyclosporin in renal transplantation by the protocol biopsies.
abstract: Acute and chronic lesion scores on renal allograft protocol biopsies may predict long-term graft function. The aim of this study was to compare the effects of tacrolimus (Tac) and cyclosporine microemulsion (CsA) based immunosuppressive protocols using protocol biopsies from well-functioning renal allografts. 35 consecutive renal transplant patients were randomized to Tac (n: 17) versus CsA (n: 18) treatment arms. Patient age and sex, donor type and age, histocompatibility, cold ischemia time and prior delayed graft function were similar between the two groups. Treatment protocol consisted of prednisolone, azathioprine and Tac or CsA. Biopsies performed on the third, sixth and twelfth months were blindly evaluated by the same pathologist. The incidences of acute rejection (AR) episodes among CsA vs Tac groups were 33% vs 29%, respectively (NS). The Creatinine level was lower in Tac than CsA, although it was not significant (Table). Subclinical AR and subclinical chronic allograft nephropathy were detected on protocol biopsies in 3 (2 CsA, 1 Tac) and 12 (7 CsA, 5 Tac) patients, respectively. Acute lesion score at the third month PBx was significantly lower in the Tac group (p < 0.05). Chronic lesion scores in all biopsies were lower in the Tac group, although not significantly. The protocol biopsy findings suggest that graft injury may be less pronounced among the Tac group.
authors.affiliation: Ege University Medical School, Nephrology Department, 35100 Bornova, zmir, Turkey. tozhus@superonline.com
authors.forename: H
authors.initials: H
authors.lastname: Töz
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: M
authors.initials: M
authors.lastname: Seziş
authors.forename: S
authors.initials: S
authors.lastname: Duman
authors.forename: M
authors.initials: M
authors.lastname: Ozkahya
authors.forename: S
authors.initials: S
authors.lastname: Ozbek
authors.forename: C
authors.initials: C
authors.lastname: Hoşcoşkun
authors.forename: G
authors.initials: G
authors.lastname: Atabay
authors.forename: E
authors.initials: E
authors.lastname: Ok
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001706:Biopsy / Q000379:methods; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008297:Male; D016343:Monitoring, Intraoperative; D015588:Observer Variation; D011183:Postoperative Complications / Q000453:epidemiology; D011239:Prednisolone / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine; D016559:Tacrolimus