title: Administration of beta2-adrenergic agonists during the peri-implantation period does not improve implantation or pregnancy rates in intracytoplasmic sperm injection (ICSI) cycles.
abstract: OBJECTIVE
  The objective of the present investigation was to determine implantation and pregnancy rates in patients undergoing ICSI and treated with beta2-adrenergic agonists, considering the uterine-relaxing action of these agents.
  
  
  METHODS
  A total of 225 women undergoing ICSI at the Center for Human Reproduction, "Sinhá Junqueira" Maternity Foundation, entered the study. Patient participation in each group was random, by drawing lots, using a randomization table previously elaborated for the study (2:2:1). The group I (90 women) received 10 mg of terbutaline daily for 15 days starting on the day of oocyte retrieval; group II (90 women) received 20 mg of ritodrine daily during the same period of time as group I; group III (45 patients) received no treatment and was used as control. The evaluation was interrupted in 3 patients of group I and in 30 patients of group II because of a high incidence of side effects.
  
  
  RESULTS
  Pregnancy, implantation, and miscarriage rates were not significantly different (p > 0.05) between the three groups: 29.88%, 13.25%, and 26.9% for group I; 33.33%, 17.5%, and 10.0% for group II; 28.88%, 15.07%, and 15.38% for group III, respectively.
  
  
  CONCLUSIONS
  The results of this study do not support the routine use of beta2-adrenergic agonists during the peri-implantation period in assisted reproductive technology cycles.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine of Botucatu (UNESP), Botucatu, Brazil.
authors.forename: Osni L
authors.initials: OL
authors.lastname: Pinheiro
authors.forename: Mario
authors.initials: M
authors.lastname: Cavagna
authors.forename: Ricardo L R
authors.initials: RL
authors.lastname: Baruffi
authors.forename: Ana L
authors.initials: AL
authors.lastname: Mauri
authors.forename: Claudia
authors.initials: C
authors.lastname: Petersen
authors.forename: José G
authors.initials: JG
authors.lastname: Franco
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D013726:Terbutaline / Q000494:pharmacology*
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000318:Adrenergic beta-Agonists; D013726:Terbutaline