title: The effect of erythropoietin on allogeneic blood requirement in patients undergoing elective liver resection: a model simulation.
abstract: We investigated whether recombinant human erythropoietin (rHuEPO) administration would reduce red blood cell (RBC) transfusion requirements in patients undergoing elective liver resection. We retrospectively investigated 200 patients undergoing elective liver resection. Factors likely to predict perioperative RBC transfusion were studied using a logistic regression analysis. A mathematical model was used to simulate RBC transfusion requirements if (a). transfusion thresholds had been predefined at a hemoglobin concentration of 7-8 g/dL, (b). preoperative hemoglobin concentrations had been increased to 15 g/dL by rHuEPO administration in patients with preoperative hemoglobin concentration in the range 10-13 g/dL, and (c). both interventions had been used. A cost/benefit evaluation of rHuEPO administration formed part of this simulation. RBC transfusion was correlated with major and median liver resection, total liver vascular exclusion, and a combined nonhepatic abdominal surgery but was not correlated with a preoperative hemoglobin concentration in the range 10-13 g/dL. Adherence to a small transfusion threshold or rHuEPO administration alone would have resulted in a slight reduction in transfusion requirements and transfusion rates for the whole population. However, the two interventions in combination would have significantly reduced both variables. One-hundred-eighteen patients undergoing median and major liver resection received 92% of RBC transfused. Sixty-six of these 118 patients had preoperative hemoglobin concentrations in the range 10-13 g/dL and could have received rHuEPO before surgery. rHuEPO alone would have avoided the transfusion of 63 RBC packs of 203 in this subgroup and 12 transfused patients of 31 (P = 0.02). rHuEPO administration to these 66 patients would have cost 186000 Euro. The 63 RBC saved would have cost 10,710 Euro.
  
  
  CONCLUSIONS
  A mathematical model simulation suggests that the routine preoperative administration of erythropoietin to patients scheduled for major and median liver resection presenting with a preoperative hemoglobin concentration in the range 10-13 g/dL could reduce blood transfusion requirements. However, the cost/benefit ratio warrants consideration.
authors.affiliation: *Departments of Anesthesia and Critical Care, †Biostatistics, and ‡Surgery, Université Paris V-René Descartes, Hôpital Cochin, Paris, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Lentschener
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gomola
authors.forename: Sophie
authors.initials: S
authors.lastname: Grabar
authors.forename: Olivier
authors.initials: O
authors.lastname: Soubrane
authors.forename: Bertrand
authors.initials: B
authors.lastname: Dousset
authors.forename: Pierre-Philippe
authors.initials: PP
authors.lastname: Massault
authors.forename: Catherine
authors.initials: C
authors.lastname: Penhoud
authors.forename: Yves
authors.initials: Y
authors.lastname: Ozier
mesh_terms: D000368:Aged; D001803:Blood Transfusion; D003198:Computer Simulation; D017707:Erythrocyte Transfusion; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D005602:France; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007432:Intraoperative Period; D008099:Liver / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015233:Models, Statistical; D011994:Recombinant Proteins; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin