title: Angiographic right and left ventricular function in arrhythmogenic right ventricular dysplasia.
abstract: We prospectively documented right ventricular (RV) and left ventricular (LV) volumes and ejection fractions in a large series of patients with arrhythmogenic RV dysplasia/cardiomyopathy (ARVD/C). Eighty-five patients with ARVD/C and 11 controls underwent 2 successive orthogonal right and left monoplane x-ray-digitized cineangiographies. Volumes were calculated using the hemielliptical RV and ellipsoidal LV models. All controls and 58 of 85 patients (ARVD/C-I) had a RV ejection fraction > or =35% and 27 patients had a RV ejection fraction <35% (ARVD/C-II). Tricuspid annulus plane systolic excursion (TAPSE) was lower in ARVD/C-II than in ARVD/C-I patients (6 +/- 3 vs 14 +/- 3 mm) and controls (16 +/- 2 mm) (each p <0.001). In patients with ARVD/C, TAPSE was positively related to RV ejection fraction (r = 0.79) and to crista supraventricularis shortening (r = 0.81) (each p <0.001). Sensitivity and specificity of TAPSE <12 mm in identifying patients with RV ejection fraction <35% were 96% and 78%, respectively. LV ejection fraction was > or =50% in 68 patients, 40% to 49% in 10, and <40% in 7. Diffuse RV outflow tract aneurysm was observed in 9 patients, all belonging to ARVD/C-II, and this sign identified patients with LV ejection fraction <40% with 86% sensitivity and 96% specificity. In conclusion, 68% of ARVD/C patients had normal RV ejection fraction and RV volumes, and 80% of ARVD/C patients had normal LV ejection fraction. Decreased TAPSE <12 mm and a diffuse RV outflow tract aneurysm were sensitive and specific indicators of RV ejection fraction <35% and LV ejection fraction <40%, respectively.
authors.affiliation: Service d'Explorations Fonctionnelles Cardiaques et Respiratoires, Paris, France. jeanlouis.hebert@bct.ap-hop-paris.fr
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Hébert
authors.forename: Denis
authors.initials: D
authors.lastname: Chemla
authors.forename: Olivier
authors.initials: O
authors.lastname: Gérard
authors.forename: Karen
authors.initials: K
authors.lastname: Zamani
authors.forename: Jeanine
authors.initials: J
authors.lastname: Quillard
authors.forename: Arshid
authors.initials: A
authors.lastname: Azarine
authors.forename: Robert
authors.initials: R
authors.lastname: Frank
authors.forename: Yves
authors.initials: Y
authors.lastname: Lecarpentier
authors.forename: Guy
authors.initials: G
authors.lastname: Fontaine
mesh_terms: D000328:Adult; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D017023:Coronary Angiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016277:Ventricular Function, Left / Q000502:physiology*; D016278:Ventricular Function, Right / Q000502:physiology*