title: Perioperative treatment with octreotide minimizes technical complications after enteric conversion of bladder-drained pancreas transplants.
abstract: We review our experience with enteric conversion of previously bladder-drained pancreas transplants (PTx) using a short perioperative course of octreotide (OCT). Between July 1994 and December 2001, 45 consecutive primary bladder-drained PTx were performed. Immunosuppression consisted of a combination of tacrolimus, mycophenolate mofetil and steroids after induction with monoclonal or polyclonal antibodies. A total of 16 patients underwent enteric conversion at an average of 3 months after the initial transplant. Each patient received OCT perioperatively. We report no technical complications with the exception of one superficial wound infection and good early and late PTx survival rates. Perioperative treatment with octreotide is well tolerated and may reduce technical complications while performing enteric conversion of previously bladder-drained PTx.
authors.affiliation: Department of Surgery, Division of Transplantation, University of Illinois at Chicago, Chicago, IL, USA.
authors.forename: Diego
authors.initials: D
authors.lastname: Bogetti
authors.forename: Sławomir
authors.initials: S
authors.lastname: Nazarewski
authors.forename: Adam
authors.initials: A
authors.lastname: Zieliński
authors.forename: Pierpaolo
authors.initials: P
authors.lastname: Sileri
authors.forename: Giuliano
authors.initials: G
authors.lastname: Testa
authors.forename: Howard
authors.initials: H
authors.lastname: Sankary
authors.forename: Enrico
authors.initials: E
authors.lastname: Benedetti
mesh_terms: D000328:Adult; D004322:Drainage / Q000009:adverse effects / Q000379:methods*; D004386:Duodenum / Q000601:surgery; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000008:administration & dosage*; D016035:Pancreas Transplantation; D011183:Postoperative Complications / Q000517:prevention & control*; D001743:Urinary Bladder / Q000601:surgery
chemical_list: D005765:Gastrointestinal Agents; D015282:Octreotide