Synthesis and evaluation of substituted 4-alkoxy-2-aminopyridines as novel neuropeptide Y1 receptor antagonists.
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure-activity relationships and identification of potent 4-alkoxy derivatives are described.
Sato
Nagaaki
N
Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300-2611, Japan. satoung@banyu.co.jp
Shibata
Takunobu
T
Jitsuoka
Makoto
M
Ohno
Toshiyuki
T
Takahashi
Toshiyuki
T
Hirohashi
Tomoko
T
Kanno
Tetsuya
T
Iwaasa
Hisashi
H
Kanatani
Akio
A
Fukami
Takehiro
T
D000631:Aminopyridines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000631:Aminopyridines; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor