Protein mis-folding emerges as a "drugable" target for discovery of novel therapies for neuropsychiatric diseases of aging.
Trojanowski
John Q
JQ
The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. trojanow@mail.med.upenn.edu
D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D001921:Brain / Q000503:physiopathology; D006801:Humans; D020125:Mutation, Missense / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D058225:Plaque, Amyloid / Q000235:genetics; D017354:Point Mutation / Q000235:genetics; D017510:Protein Folding; D051843:Synucleins; D016875:tau Proteins / Q000235:genetics
D009419:Nerve Tissue Proteins; D051843:Synucleins; D016875:tau Proteins