Massive nasal bleeding and hemodynamic instability associated with clopidogrel.
A 58-year-old woman was brought to our emergency department with massive nasal bleeding and hemodynamic instability. The patient had been on clopidogrel treatment (75 mg/day) for 2 years, which was started after an episode of transitory ischemic attack. Blood pressure normalized following the administration of intravenous fluids, and the bleeding stopped after nasal tamponade and desmopressin therapy.
Nácul
Flávio E
FE
Clinical Research Center & Intensive Care Medicine, Clínica São Vicente, Rua João Borges 204, Rio de Janeiro, RJ 22451-100, Brazil. pesquisa@svgavea.com.br
de Moraes
Emanuela
E
Penido
Carmen
C
Paiva
Roberto B
RB
Méier-Neto
João G C
JG
D000077144:Clopidogrel; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D004844:Epistaxis / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D002546:Ischemic Attack, Transient / Q000188:drug therapy; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects* / Q000031:analogs & derivatives*
D006490:Hemostatics; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D003894:Deamino Arginine Vasopressin; D013988:Ticlopidine