title: Growth and metabolic control during puberty in girls with X-linked hypophosphataemic rickets.
abstract: OBJECTIVE
  X-linked hypophosphataemic rickets (XLH) results in defective bone mineralization and impaired growth. Treatment with oral phosphate (Pi) and calcitriol improves but does not normalize growth. This study assessed whether pubertal growth and metabolic control contribute to the height deficit.
  
  
  METHODS
  Study included patients with XLH who were treated with Pi-calcitriol from diagnosis to adult height; their hospital records, biochemistry and radiographs were reviewed.
  
  
  RESULTS
  Six females with XLH were included. Their mean peak height velocity and total height gain during puberty were nearly normal despite deteriorating metabolic control.
  
  
  CONCLUSIONS
  In treated girls with XLH, the pubertal growth is nearly normal despite suboptimal metabolic control. The major height loss occurs prior to puberty and is not recovered during the pubertal growth spurt.
authors.affiliation: Division of Endocrinology, Hospital for Sick Children, University of Toronto, Toronto, Ont, Canada.
authors.forename: Etienne
authors.initials: E
authors.lastname: Sochett
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Doria
authors.forename: Flavia
authors.initials: F
authors.lastname: Henriques
authors.forename: Sang Whay
authors.initials: SW
authors.lastname: Kooh
authors.forename: Alan
authors.initials: A
authors.lastname: Daneman
authors.forename: Outi
authors.initials: O
authors.lastname: Mäkitie
mesh_terms: D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D007223:Infant; D011627:Puberty; D011859:Radiography; D012720:Severity of Illness Index