Amantadine penetration into cerebrospinal fluid of a child with influenza A encephalitis.
The use of amantadine has been advocated as treatment for influenza A encephalitis despite limited information regarding cerebrospinal fluid concentrations and the pathogenesis of encephalitis associated with influenza virus infections. We report a 2-year-old child with influenza A encephalitis treated with amantadine who achieved a potentially therapeutic concentration in cerebrospinal fluid. Despite this the child developed significant neurologic impairment.
Geskey
Joseph M
JM
Department of Pediatrics, Penn State Children's Hospital, Penn State University College of Medicine, Hershey, PA, USA.
Thomas
Neal J
NJ
D000208:Acute Disease; D000547:Amantadine / Q000493:pharmacokinetics*; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D002555:Cerebrospinal Fluid / Q000821:virology*; D018792:Encephalitis, Viral / Q000188:drug therapy* / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D009980:Influenza A virus; D007251:Influenza, Human / Q000150:complications* / Q000175:diagnosis / Q000821:virology
D000998:Antiviral Agents; D000547:Amantadine