Pi-delocalized beta-carbolinium cations as potential antimalarials.
Several beta-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral beta-carbolines and a good correlation was observed between pi-delocalized lipophilic cationic structure and antimalarial efficacy.
Takasu
Kiyosei
K
Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan. kay-t@mail.pharm.tohoku.ac.jp
Shimogama
Tsubasa
T
Saiin
Chalerm
C
Kim
Hye-Sook
HS
Wataya
Yusuke
Y
Ihara
Masataka
M
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry* / Q000494:pharmacology*; D002412:Cations; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development
D000962:Antimalarials; D002243:Carbolines; D002412:Cations