[Histologic study on impeding leukoplakia carcinogenesis of golden hamster cheek pouch about Erigeron breviscapus (Vant) Hand-Mazz].
OBJECTIVE
To observe the effect of Erigeron breviscapus (Vant) Hand Mazz (HEr) in impeding oral leukoplakia carcinogenesis, and to seek effective Chinese herb medicine that can impede precarcinoma of oral mucosas.


METHODS
132 golden hamsters were randomly divided into model group (60 animals), HEr group (60 animals), and control group 12 animals. Salley's leukoplakia carcinogenesis model of golden hamster cheek pouch was used in this study. HEr was injected into the stomach to impede evolution of carcinogenesis. Pathological specimens were observed via naked eye and light microscope between model group and HEr group. Results were compared.


RESULTS
Observation via naked-eye showed that leukoplakia rate of HEr group (18.2%) was lower than that of model group (27.3%). Observation via light microscope showed that carcinogenesis rate descended one fold and displasia rate descended 0.4 fold in HEr group.


CONCLUSIONS
HEr has exact effect in impeding leukoplakia carcinogenesis.
Zhou
C T
CT
Department of Oral Medicine, Shanghai Ninth People's Hospital, School of Stomotology, Shanghai Second Medical University. Shanghai 200011, China.
Zhong
W J
WJ
Hua
L
L
Hu
H F
HF
Jin
Z G
ZG