Skeletal resistance to parathyroid hormone as a background abnormality in uremia.
Skeletal resistance to parathyroid hormone (PTH) is a background abnormality underlying uremic bone disease. This abnormality exists even with high PTH. By the suppression of PTH, it has become uncovered, presenting as adynamic bone disease. Since patients with adynamic bone disease have higher risk of hypercalcemia or lumber fracture, mechanisms of this skeletal resistance to PTH need to be elucidated for the optimal management of bone turnover and parathyroid function in chronic dialysis patients.
Fukagawa
Masafumi
M
Division of Nephrology, Kobe University School of Medicine, Kusunoki-cho, Chuo-ku, Japan. fukagawa@med.kobe-u.ac.jp
Iwasaki
Yoshiko
Y
Kazama
Junichiro J
JJ
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000503:physiopathology*; D006801:Humans; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology*; D014511:Uremia / Q000097:blood*
D010281:Parathyroid Hormone