Medicinal plants in Suriname: hypotensive effect of Gossypium barbadense.
In traditional medicine Gossypium barbadense L. is used against hypertension. Looking for a scientific basis for this use, the blood-pressure-lowering effect of the decoction of the leaves was confirmed. Fraction II (frII) of the crude extract of G. barbadense showed a dose-dependent hypotensive effect in anaesthetized rats. In hexamethonium-treated rats, the blood-pressure-lowering effect of frII was almost abolished. A small decrease of the blood-pressure-lowering effect was followed by an increase in the blood pressure. Phentolamine antagonized the increase in blood pressure in hexamethoniumtreated rats. High doses of atropine (4 mg/rat) suppressed both depressor and heart effects. In-vitro experiments revealed that atropine did not antagonize the contraction of the ileum of the rat. Tripelennamine in a concentration of 100 microg could not influence the contraction either, whereas 300 microg did. In the guinea-pig ileum 10 microg tripelennamine did not reduce the contraction significantly. In the mechanism of action of frII, acetylcholine receptors could be involved, but not histaminergic or adrenergic receptors. Although it is still not known which compound(s) in G. barbadense is (are) the active substance(s), the results obtained may explain the use of this plant in traditional medicine in Suriname.
Hasrat
J A
JA
Department of Pharmacology, Faculty of Medicinal Sciences, Paramaribo, Suriname.
Pieters
L
L
Vlietinck
A J
AJ
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D003368:Gossypium; D006168:Guinea Pigs; D018738:Hexamethonium / Q000494:pharmacology; D007022:Hypotension / Q000139:chemically induced*; D007082:Ileum / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008519:Medicine, Traditional; D009119:Muscle Contraction; D010643:Phenoxybenzamine / Q000008:administration & dosage; D010936:Plant Extracts / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D011433:Propranolol / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013532:Suriname; D014867:Water
D010936:Plant Extracts; D014867:Water; D010643:Phenoxybenzamine; D018738:Hexamethonium; D001285:Atropine; D011433:Propranolol