Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii. II. Physico-chemical properties and structure elucidation.
New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and extract of mycelium of Eupenicillium shearii F80695. The structures of melanocins were established by spectroscopic methods. They are formamide compounds. In particular, melanocin A has an isocyanide group.
Kim
Jong-Pyung
JP
Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea.
Kim
Byoung-Kwon
BK
Yun
Bong-Sik
BS
Ryoo
In-Ja
IJ
Lee
In-Kyoung
IK
Kim
Won-Gon
WG
Pyun
Yu-Ryang
YR
Yoo
Ick-Dong
ID
D002074:Butanones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003486:Cyanides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005559:Formamides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D015394:Molecular Structure; D010407:Penicillium / Q000378:metabolism*
D002074:Butanones; D003486:Cyanides; D005559:Formamides; D008543:Melanins; C484096:melanocin A; C484095:melanocin B; C484097:melanocin C