title: Haemodynamic effects of a milrinone infusion without a bolus in patients undergoing off-pump coronary artery bypass graft surgery.
abstract: The haemodynamic effects of a continuous infusion of milrinone without an initial bolus dose were evaluated in patients undergoing off-pump coronary artery bypass graft surgery. After internal mammary artery harvest, milrinone 0.5 microg.min(-1).kg(-1) (29 patients) or a normal saline infusion (33 patients) was started and continued until all graft anastomoses were completed. Haemodynamic variables were recorded before application of the tissue stabiliser, at 1, 3, 5 and 10 min after the application of the stabiliser, and after its removal. The administration of a milrinone infusion was associated with a smaller decrease in cardiac output and mixed venous oxygen saturation during all the coronary artery anastomoses, with no severe complications and a decreased dose of norepinephrine infused to maintain systemic arterial pressure.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University School of medicine, 134 Shinchon-Dong, Seodaemun-Gu, Seoul 120-752, Korea. ylkwak@yumc.yonsei.ac.kr
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwak
authors.forename: Y J
authors.initials: YJ
authors.lastname: Oh
authors.forename: H K
authors.initials: HK
authors.lastname: Shinn
authors.forename: K J
authors.initials: KJ
authors.lastname: Yoo
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: Y W
authors.initials: YW
authors.lastname: Hong
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007387:Internal Mammary-Coronary Artery Anastomosis / Q000379:methods*; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*
chemical_list: D002316:Cardiotonic Agents; D010726:Phosphodiesterase Inhibitors; D020105:Milrinone; D010100:Oxygen