[Myoclonic encephalopathy associated with proton pump inhibitors].
Two men (66 and 73 Years) with a cardiovascular history were hospitalized for rapid onset encephalopathy associated with myoclonia and an extrapyramidal syndrome. On the basis of the French Pharmacovigilance system, this symptomatology has been attributed to the coadministration of a proton pump inhibitor, lansoprazole (15mg/day) with levodopa. Lansoprazole withdrawal led to a normalisation of the situation.
Boulliat
J
J
Service de Neurologie, Centre Hospitalier, Bourg en Bresse.
Polard
E
E
Colin
F
F
Bentué-Ferrer
D
D
Allain
H
H
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001927:Brain Diseases / Q000139:chemically induced*; D006801:Humans; D064747:Lansoprazole; D009207:Myoclonus / Q000139:chemically induced*; D009853:Omeprazole / Q000009:adverse effects* / Q000031:analogs & derivatives*; D054328:Proton Pump Inhibitors
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D009853:Omeprazole