Antinociceptive effects of hydroalcoholic extract and essential oil of Zataria multiflora.
Antinociceptive effect of hydroalcoholic extract and essential oil of Zataria multiflora was studied using writhing, tail flick and formalin tests. In tail flick test, the hydroalcholic extract (500 mg/kg, i.p.) and the essential oil (0.3 ml/kg, i.p.) of the plant showed antinociceptive activity (P<0.05). Moreover, they showed antinociceptive activity in writhing and formalin tests.
Jaffary
Fariba
F
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. jaffary@pharm.mui.ac.ir
Ghannadi
Alireza
A
Siahpoush
Amir
A
D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D010936:Plant Extracts; D010938:Plant Oils; D005557:Formaldehyde