Different dopamine D1 and D2 receptors expression after motor activity in the striatal critical period.
Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decrease of 40% in D2R binding sites (p<0.01) and of 45% in the D2R mRNA expression which involve short (p<0.05) and long (p<0.01) isoforms. In contrast, D1R binding sites nor its mRNA expression levels were affected by training, indicating a differential synaptic refinement during this ontogenetically fixed period.
Soiza-Reilly
Mariano
M
Laboratorio de Biología Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 4 Piso, Pabellón II, Ciudad Universitaria (C1428EHA), Buenos Aires, Argentina.
Fossati
Mariana
M
Ibarra
Gustavo R
GR
Azcurra
Julio M
JM
D000818:Animals; D003342:Corpus Striatum / Q000254:growth & development / Q000378:metabolism*; D003423:Critical Period, Psychological; D005786:Gene Expression Regulation / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000096:biosynthesis* / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000096:biosynthesis* / Q000235:genetics
D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2