title: To the 30-nm chromatin fiber and beyond.
abstract: Chromatin fibers are intrinsically dynamic macromolecular complexes whose biological functions are intimately linked with their structure and interactions with chromatin-associated proteins (CAPs). Three-dimensional architectural transitions between or within the two co-existing chromatin types referred to as euchromatin and heterochromatin have been associated with activation or repression of nuclear functions. The presence of specific subsets of chromosomal proteins co-existing with the different chromatin conformations suggests a functional significance for their co-localization. The major points of emphasis of this review will assess the structure, function and recently documented exchanges amongst various members of the CAP family.
authors.affiliation: Department of Biological Sciences, College of Science, Marshall University, 1 John Marshall Drive, Huntington, WV 25701, USA.
authors.forename: Nicholas L
authors.initials: NL
authors.lastname: Adkins
authors.forename: Meagan
authors.initials: M
authors.lastname: Watts
authors.forename: Philippe T
authors.initials: PT
authors.lastname: Georgel
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000737:chemistry / Q000378:metabolism; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure*; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D024002:HMGB Proteins / Q000737:chemistry / Q000378:metabolism; D024001:HMGN Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2; D012097:Repressor Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
chemical_list: D030161:Avian Proteins; C453799:Cbx3 protein, mouse; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D024002:HMGB Proteins; D024001:HMGN Proteins; D006657:Histones; C497392:MECP2 protein, human; C081441:MENT protein, Gallus gallus; D051783:Methyl-CpG-Binding Protein 2; D012097:Repressor Proteins; C084122:SIR3 protein, S cerevisiae; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D004247:DNA