Electrophysiological insights into the mechanism of ion-coupled cotransporters.
Most ion-coupled cotransporters display, in the absence of organic substrate, transient currents resembling the gating currents of voltage-dependent ion channels. Detailed comparison of these currents in different ionic and temperature conditions with the corresponding steady-state currents when translocation of the substrate occurs reveals new insights into the mechanisms of the process.
Peres
Antonio
A
Laboratory of Cellular and Molecular Physiology, Department of Structural and Functional Biology, and Center for Neurosciences, University of Insubria, 21100 Varese, Italy.
Giovannardi
Stefano
S
Bossi
Elena
E
Fesce
Riccardo
R
D000818:Animals; D004594:Electrophysiology; D007473:Ion Channels / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology*; D008954:Models, Biological
D007473:Ion Channels