Cortical control of microtubule stability and polarization.
In both dividing and interphase cells, microtubules are remodeled in response to signal transduction pathways triggered by a variety of stimuli. Members of the Rho family of small GTPases have emerged as key intermediates in transmitting signals to cortical factors that mediate capture of dynamic microtubules at specific sites. The specificity of cortical capture appears to be controlled by microtubule tip proteins and cortical receptors that bind these proteins. Recent studies suggest that some of the proteins interacting with microtubule tips behave as bridging proteins between the microtubule tip proteins and their cortical receptors. Such bridging proteins may enhance cortical capture of microtubules directly or indirectly through interactions with the actin cytoskeleton.
Gundersen
Gregg G
GG
Department of Anatomy & Cell Biology, Columbia University, Black Building 1217, 630 W. 168th Street, New York, NY 10032, USA. ggg1@columbia.edu
Gomes
Edgar R
ER
Wen
Ying
Y
D000818:Animals; D002455:Cell Division; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000502:physiology*
D020741:rho GTP-Binding Proteins