Self-assembling peptide nanotubes from enantiomeric pairs of cyclic peptides with alternating D and L amino acid residues.
Cyclic peptides with alternating d- and l-amino acid residues containing tert-leucine residues in every second position can form peptide nanotubes only when both enantiomers of the peptide are present in the solution. These results strongly indicate the formation of peptide nanotubes that assemble with one enantiomer in every second position, thereby forming a lamellar structure.
Rosenthal-Aizman
Katri
K
Department of Neurochemistry and Neurotoxicology and Department of Structural Chemistry, Stockholm University, S-10691, Stockholm, Sweden.
Svensson
Gunnar
G
Undén
Anders
A
D000585:Aminacrine / Q000737:chemistry*; D008958:Models, Molecular; D045333:Nanotubes, Peptide / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
D045333:Nanotubes, Peptide; D010456:Peptides, Cyclic; D000585:Aminacrine