Two new cytotoxic isoprenylated flavones, artoindonesianins U and V, from the heartwood of Artocarpus champeden.
Two new isoprenylated flavones, artoindonesianins U (1) and V (2), have been isolated from the heartwood of Artocarpus champeden together with three known isoprenylated flavonoids, 5'-hydroxycudraflavone A, cyclocommunin and artonin B. The structures of the new flavones were elucidated on the basis of spectroscopic evidence. Both compounds 1 and 2 showed strong cytotoxic activity against P-388 cell lines.
Syah
Yana M
YM
Department of Chemistry, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia.
Achmad
Sjamsul A
SA
Ghisalberti
Emilio L
EL
Hakim
Euis H
EH
Mujahidin
Didin
D
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D031622:Artocarpus; D045744:Cell Line, Tumor / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D010936:Plant Extracts; C485798:artoindonesianin U; C485797:artoindonesianin V