Fatty acid metabolism and vascular disease.
Fatty acid metabolism is abnormal in insulin-resistant states that increase the risk of atherosclerosis such as type 2 diabetes and the metabolic syndrome. How fatty acids promote vascular disease is poorly understood, but lipoprotein lipase and peroxisome proliferator-activated receptor alpha (PPARalpha)-physiologically related proteins involved in fatty acid metabolism-may be involved. Glucocorticoid metabolism is also abnormal in insulin-resistant states and may promote several components of the metabolic syndrome. Recent studies have shown that hepatic fatty acid metabolism is required for the development of insulin resistance and hypertension caused by glucocorticoid excess, suggesting that crosstalk between glucocorticoid receptor-and PPARalpha-dependent pathways may contribute to vascular disease.
Semenkovich
Clay F
CF
Clay F. Semenkovich is at the Departments of Medicine and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. csemenko@im.wustl.edu
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008099:Liver / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014652:Vascular Diseases / Q000209:etiology / Q000378:metabolism*
D004268:DNA-Binding Proteins; D005227:Fatty Acids; D005938:Glucocorticoids; D018160:Receptors, Cytoplasmic and Nuclear; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors; D008071:Lipoprotein Lipase