Malignant peripheral nerve sheath tumor arising from an adrenal ganglioneuroma in a 6-year-old boy.
This report describes the youngest patient to develop a malignant peripheral nerve sheath tumor arising from a ganglioneuroma (MPNST ex Ganglioneuroma). The patient, a 6-year-old boy, was never irradiated and had no history or stigmata of neurofibromatosis. The report also includes a review of the previously published related cases, and an analysis of the immunohistochemistry and electron microscopy data available to date on the subject.
de Chadarévian
Jean-Pierre
JP
Department of Pathology and Laboratory Medicine, St. Christopher's Hospital for Children, and Drexel University College of Medicine, Philadelphia, PA 19134, USA. jd37@drexel.edu
MaePascasio
Judy
J
Halligan
Gregory E
GE
Katz
Douglas A
DA
Locono
Joseph A
JA
Kimmel
Stephen
S
Katsetos
Christos D
CD
D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000628:therapy / Q000652:urine; D000315:Adrenalectomy; D000971:Antineoplastic Combined Chemotherapy Protocols; D002648:Child; D005729:Ganglioneuroma / Q000473:pathology* / Q000628:therapy / Q000652:urine; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000473:pathology* / Q000628:therapy / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine
D014642:Vanilmandelic Acid; D006719:Homovanillic Acid