title: [Clinical experience with the use of infliximab in 44 patients with Crohn's disease].
abstract: OBJECTIVE
  To evaluate the efficacy of infliximab in the treatment of patients with active Crohn's disease or with fistulas.
  
  
  METHODS
  Forty four patients with Crohn's disease, resistant to conventional therapies, were treated with 5 mg/kg endovenous infliximab infusions.
  
  
  RESULTS
  Thirty of them (68.2%) improved, with important reduction on disease activity levels, measured by the CDAI (Crohn's Disease Activity Index). Eight (57.1%) of 14 patients with fistulas also showed good results, with closure or important reduction in their flow. The drug was well tolerated in all cases.
  
  
  CONCLUSIONS
  The use of infliximab in these cases seems to be a good therapeutic option, with low rates of side effects.
authors.affiliation: Hospital Israelita Albert Eisntein e no Hospitl Alemão Oswaldo Cruz, São Paulo, SP, Brazil. steinwu@attglobal.net
authors.forename: Flavio
authors.initials: F
authors.lastname: Steinwurz
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002648:Child; D003424:Crohn Disease / Q000188:drug therapy*; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D007412:Intestinal Fistula / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab