[Age-related characteristics of cataractogenesis in salmon fry. II. Biochemical characteristics of eye lens during cataractogenesis].
We studied biochemical features of the lipid and phospholipid composition and patter of fatty acid spectra in lenses of one and two year old salmons bearing cataracts. The lipid complex of lenses of diseased fish underwent significant changes. Cataractogenesis was accompanied by enhanced free radical oxidation and accumulation of malone dialdehyde in lenses of salmons of various age. The intensification of oxidative processes was synchronized with the decreased level of antioxidant protection (reduced glutathione, vitamins A and E). The activity of Ca(2+)-dependent proteolytic enzymes in lenses was determined and its decrease in the case of cataract was shown.
Toĭvonen
L V
LV
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg, 194223 Russia.
Nefedova
Z A
ZA
Sidorov
V S
VS
Iurovitskiĭ
Iu G
IuG
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002386:Cataract / Q000378:metabolism* / Q000662:veterinary; D005227:Fatty Acids / Q000378:metabolism; D005393:Fish Diseases / Q000378:metabolism*; D007908:Lens, Crystalline / Q000378:metabolism*; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D012474:Salmon / Q000254:growth & development* / Q000378:metabolism
D005227:Fatty Acids; D008054:Lipid Peroxides