title: Changes in the spontaneous and stimulus-evoked activity in the somatosensory cortex of rats on acute manganese administration.
abstract: In this work, acute effects of inorganic manganese exposure on nervous electrical activity of rats were investigated. Young adult male Wistar rats were prepared for recording in anaesthesia and spontaneous cortical as well as stimulus-evoked cortical and peripheral nervous activity was recorded before and after i.p. administration of 25 and 50 mg/kg Mn2+. The alterations found resulted possibly from several known neuronal effects of manganese. The frequency shift of spontaneous cortical activity, and increased latency and decreased amplitude of the peripheral nerve action potential, were probably due to the Mn(2+)-induced impairment of the mitochondria, whereas the increased amplitude of the evoked cortical response, to the effect on glutamatergic transmission.
authors.affiliation: Department of Public Health, University of Szeged, H-6720 Szeged, Dóm tér 10., Hungary. ppp@puhe.szote.u-szeged.hu
authors.forename: László
authors.initials: L
authors.lastname: Pecze
authors.forename: András
authors.initials: A
authors.lastname: Papp
authors.forename: László
authors.initials: L
authors.lastname: Nagymajtényi
mesh_terms: D000200:Action Potentials; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007263:Infusions, Parenteral; D008297:Male; D020149:Manganese Poisoning / Q000503:physiopathology* / Q000662:veterinary; D051381:Rats; D017208:Rats, Wistar; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*
chemical_list: D017981:Receptors, Neurotransmitter; C069474:glutamine receptor