title: Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia.
abstract: Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-related proteins CD95, Bcl-2, Bax, Bcl-xL, procaspase-3, XIAP, cIAP-1, and survivin differ between children and adults with de novo AML.
authors.forename: Christian
authors.initials: C
authors.lastname: Wuchter
authors.forename: Stephan
authors.initials: S
authors.lastname: Richter
authors.forename: Doreen
authors.initials: D
authors.lastname: Oltersdorf
authors.forename: Leonid
authors.initials: L
authors.lastname: Karawajew
authors.forename: Wolf-Dieter
authors.initials: WD
authors.lastname: Ludwig
authors.forename: Ingo
authors.initials: I
authors.lastname: Tamm
mesh_terms: D000208:Acute Disease; D051017:Apoptosis Regulatory Proteins / Q000097:blood*; D002648:Child; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D051017:Apoptosis Regulatory Proteins