title: [The prevalence analysis of cleft palate in Chinese perinatals: 1996-2000].
abstract: OBJECTIVE
  To study the epidemiological features of cleft palate (CP) in Chinese perinatals.
  
  
  METHODS
  Data from 1996 to 2000 were collected through Chinese Birth Defects Monitoring Network a hospital based congenital malformation registry system. During that period all live or still births with 28 weeks of gestation or more were assessed within 7 days after delivery.
  
  
  RESULTS
  499 perinatals with CP were identified among 2,218,616 births, then the overall prevalence rates of CP were 2.25/10,000, rates in isolated and syndromic CP were 1.75/10,000, 0.50/10,000 respectively. The rates in urban and rural area, in male and female births were 2.27/10,000 and 2.19/10,000, 1.93/10,000 and 2.57/10,000 respectively. The highest but nonsignificant rate (2.84/10,000) was found in maternal age group of more than 35 years. An increased trend was found both in overall CP and syndromic CP during that period. Geographic variation was found among provinces. The perinatal mortality rate of CP was 14.9%, and the rate of isolated forms was 7.3%, while the rate of syndromic CP was as high as 41.4%.
  
  
  CONCLUSIONS
  The increasing prevalence rate of syndromic CP can account for the secular trend of overall CP. Female predominance was only observed in isolated forms of CP among Chinese perinatals. Geographic variation was identified too. Due to poor birth quality, perinatals suffering from syndromic CP had poor prognosis.
authors.affiliation: National Center for Birth Defects Monitoring, West China Second Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Li
authors.initials: L
authors.lastname: Dai
authors.forename: Lei
authors.initials: L
authors.lastname: Miao
authors.forename: Guang-xuan
authors.initials: GX
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Gang
authors.initials: G
authors.lastname: Li
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D002972:Cleft Palate / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D011247:Pregnancy; D012737:Sex Factors