title: Beta-globin gene cluster haplotypes in the Corsican and Sardinian populations.
abstract: The distribution of beta-globin cluster haplotypes has been studied in the populations of Corsica (France) and Sardinia (Italy). The analysis was carried out using five restriction fragment length polymorphism markers on chromosome 11 inside the beta-globin cluster using the restriction enzymes HincII and HindIII. The results show a remarkable heterogeneity within the two islands. However, the presence of rare haplotypes common to the most conservative areas (Nuoro and Corte) of the two islands is particularly interesting. These data support the hypothesis of a common origin of the populations of Sardinia and Corsica during the middle and upper Paleolithic periods and could be interpreted as a founder effect.
authors.affiliation: Dipartimento di Biologia Sperimentale, Sezione Scienze Antropologiche, Università degli Studi di Cagliari, Cagliari, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Latini
authors.forename: Lucia
authors.initials: L
authors.lastname: Vacca
authors.forename: Maria Serafina
authors.initials: MS
authors.lastname: Ristaldi
authors.forename: Maria Franca
authors.initials: MF
authors.lastname: Marongiu
authors.forename: Marc
authors.initials: M
authors.lastname: Memmì
authors.forename: Laurent
authors.initials: L
authors.lastname: Varesi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vona
mesh_terms: D005260:Female; D005602:France; D005787:Gene Frequency / Q000235:genetics; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D005914:Globins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007558:Italy; D008297:Male; D005810:Multigene Family / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D005819:Genetic Markers; D005914:Globins