title: Cancer mortality and morbidity among Lithuanian asbestos-cement producing workers.
abstract: OBJECTIVE
  This study investigated the incidence of cancer and cause-specific mortality among workers in the two Lithuanian asbestos-cement factories.
  
  
  METHODS
  The study included 1887 asbestos-cement workers, 1285 men and 602 women, and 37000 person-years. The two factories were active from 1956 (A) and 1963 (B), and the workers were observed from 1978 to 2000. The analysis was based on a comparison between the observed and expected numbers of cancer and causes of death. The observed numbers of cancer were obtained through linkage with the national cancer registry. The date and causes of death were obtained from two different sources. The expected numbers were calculated on the basis of gender- and age-specific incidence and mortality rates in 5-year periods from the whole country. Standardized incidence ratios (SIR) and standardized mortality ratios (SMR) and 95% confidence intervals (95% CI) were calculated. Duration of employment and time since first exposure were used as indicators of exposure.
  
  
  RESULTS
  During the follow-up, 1978-2000. 473 deaths were observed versus 489 expected. There was no excess risk of deaths from nonmalignant respiratory diseases, except for an elevated risk of mortality in relation to the digestive organs other than cancer, 18 observed versus 12.2 expected (95% CI 0.9-2.3). There was no excess risk for any types of cancer, except for colorectal cancer in men, 17 observed cases (SIR 1.6, 95% CI 1.6-2.6) and one case of mesothelioma in a woman.
  
  
  CONCLUSIONS
  This study on asbestos-exposed workers did not show any excess risk of respiratory cancer or deaths of pneumoconiosis.
authors.affiliation: Lithuanian Cancer Registry, Oncology Institute of Vilnius University, Lithuania. giedresm@one.lt
authors.forename: Giedre
authors.initials: G
authors.lastname: Smailyte
authors.forename: Juozas
authors.initials: J
authors.lastname: Kurtinaitis
authors.forename: Aage
authors.initials: A
authors.lastname: Andersen
mesh_terms: D000328:Adult; D017632:Asbestos, Serpentine / Q000633:toxicity*; D002423:Cause of Death; D015331:Cohort Studies; D003252:Construction Materials / Q000009:adverse effects*; D003644:Death Certificates; D005260:Female; D006801:Humans; D015994:Incidence; D008097:Lithuania / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D012042:Registries; D018570:Risk Assessment; D012737:Sex Factors; D013997:Time Factors
chemical_list: D017632:Asbestos, Serpentine