Spectroscopic investigation of interactions between dipeptides and vanadate(V) in solution.
The reaction of vanadate(V) with a series of dipeptides (Val-Gln, Ala-Gln, Gly-Gln, Gly-Glu, and Ala-Gly) was investigated by UV-visible spectroscopy and multinuclear ((51)V, (14)N, (13)C) NMR spectroscopy in solution. It was possible to evaluate the formation constants of the corresponding complexes for which a molecular structure was proposed. Complex formation is favored by the presence of a functionalized or a sterically demanding side chain. The Val-Gln dipeptide which combines both properties exhibits one of the highest formation constant reported so far for dipeptides.
Durupthy
Olivier
O
Laboratoire Chimie de la Matière Condensée, UMR CNRS 7574, Tour 54 E5, Université Pierre et Marie Curie (Paris 6), 4 place Jussieu, 75252 Paris Cedex 05, France.
Coupé
Aurélie
A
Tache
Lawrence
L
Rager
Marie-Noëlle
MN
Maquet
Jocelyne
J
Coradin
Thibaud
T
Steunou
Nathalie
N
Livage
Jacques
J
D004151:Dipeptides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014638:Vanadates / Q000737:chemistry*
D004151:Dipeptides; D012996:Solutions; D014638:Vanadates