title: [Administration of iodinated contrast in patients with pre-existing renal failure: a review].
abstract: Contrast-induced nephropathy (CIN) is an important and well-known cause of acute renal failure. The published literature contains numerous clinical trials describing the relative performance of various contrast agents. This review provides a comparison of different contrast agents and assesses the relative risk of clinical nephrotoxicity among them in patients with pre-existing renal insufficiency, which appear to be the patients at highest risk for CIN with all classes of these agents. Overall, the nonionic dimeric agents perform similarly to the nonionic monomeric agents in this regard.
authors.affiliation: Group Medical Affairs, Bracco Imaging SpA, Milano.
authors.forename: Alberto
authors.initials: A
authors.lastname: Spinazzi
authors.forename: Roberto
authors.initials: R
authors.lastname: Pozzi Mucelli
mesh_terms: D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D048909:Diabetes Complications; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects; D004311:Double-Blind Method; D006801:Humans; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects; D007479:Iopamidol / Q000008:administration & dosage / Q000009:adverse effects; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced*; D015999:Multivariate Analysis; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D051437:Renal Insufficiency / Q000150:complications*; D012306:Risk; D012307:Risk Factors; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D003287:Contrast Media; D010919:Placebos; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007472:Iohexol; D003404:Creatinine; C044834:iodixanol; D007479:Iopamidol