CD4 T cell activation and disease activity at onset of multiple sclerosis.
We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients.
Jensen
J
J
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup DK-2600, Denmark.
Langkilde
A R
AR
Fenst
C
C
Nicolaisen
M S
MS
Roed
H G
HG
Christiansen
M
M
Sellebjerg
F
F
D000328:Adult; D000943:Antigens, Differentiation / Q000097:blood / Q000134:cerebrospinal fluid; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018819:Dipeptidyl Peptidase 4 / Q000097:blood / Q000134:cerebrospinal fluid; D004185:Disability Evaluation; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D008213:Lymphocyte Activation / Q000276:immunology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D004676:Myelin Basic Protein / Q000097:blood / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000097:blood / Q000276:immunology / Q000503:physiopathology; D015375:Receptors, Interleukin-2 / Q000378:metabolism
D000943:Antigens, Differentiation; D007074:Immunoglobulin G; D004676:Myelin Basic Protein; D015375:Receptors, Interleukin-2; D018819:Dipeptidyl Peptidase 4