title: Seroepidemiology of dengue in the adult population of Singapore.
abstract: Urbanization is one of the reasons for the resurgence of dengue in tropical and subtropical countries. We conducted a cross-sectional seroepidemiological study in Singapore to determine the extent at which the Singapore population has been exposed to dengue infections. Dengue antibodies were measures with PanBio Dengue. Of 298 enrolled subjects (age 18-45), 133 (45%) had a positive dengue serology. In multivariate analysis, age and nationality (Singaporean vs non-Singaporean Asians) were found to be significant independent predictors. The odds ratio of dengue seroprevalence increased by 4.13 (95% CI: 2.88-5.93) for every 10 year increase in age. Dengue infections remain a major problem in Singapore.
authors.affiliation: Department of Infectious Diseases, Tan Tock Seng Hospital, Jalan Tan Tock Seng, Singapore. epvws@pacific.net.sg
authors.forename: Annelies
authors.initials: A
authors.lastname: Wilder-Smith
authors.forename: Winnie
authors.initials: W
authors.lastname: Foo
authors.forename: Arul
authors.initials: A
authors.lastname: Earnest
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Sremulanathan
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Paton
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000914:Antibodies, Viral / Q000032:analysis; D003430:Cross-Sectional Studies; D003715:Dengue / Q000453:epidemiology* / Q000208:ethnology / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D016036:Seroepidemiologic Studies; D012846:Singapore / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral