title: Female rats living in small cages respond to restraint stress with both adrenocortical corticosterone release and acetylcholine release in the hippocampus.
abstract: Since we found that the stress response of acetylcholine release in the hippocampus was attenuated in male rats living in a small cage, we individually housed female rats in a large (diameter=35 cm) or a small (19 cm) cylindrical cage for 4 days and examined the response to restraint stress which was applied from 12:00 h to 13:00 h. Both groups of rats showed a significant increase in the acetylcholine release in the hippocampus, as well as an increase in corticosterone release. But neither housing condition affected the expression of the 4-day estrous cycle. We surmise that there may be a sex difference in the effect of housing condition in the stress response of acetylcholine release in the hippocampus.
authors.affiliation: Department of Neuroendocrinology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura Kanazawaku, Yokohama 236-0004, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Masuda
authors.forename: Dai
authors.initials: D
authors.lastname: Mitsushima
authors.forename: Fukuko
authors.initials: F
authors.lastname: Kimura
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000302:Adrenal Cortex / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004780:Environment, Controlled; D030762:Estrous Cycle / Q000502:physiology; D045604:Extracellular Fluid / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D006799:Housing, Animal; D017551:Microdialysis; D009434:Neural Pathways / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012686:Septal Nuclei / Q000378:metabolism; D012727:Sex Characteristics; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D000109:Acetylcholine; D003345:Corticosterone