title: Analgesic effects of crude extracts of Miconia albicans (Melastomataceae).
abstract: The present study describes the analgesic effects of the crude extracts (hexane, methylene chloride and ethanol) obtained from the aerial parts of Miconia albicans (Melastomataceae) using the writhing test and the hot plate models for pain in mice. The extracts in hexane and methylene chloride, given orally, produced significant antinociception in the writhing test. On the other hand, none of the extracts had a significant effect on the hot plate test, a fact suggesting that the substances present in the extracts may rather have peripheral analgesic activity.
authors.affiliation: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas da Universidade de Franca--Pq. Universitário, Franca-SP, Brazil.
authors.forename: M A Lemos
authors.initials: MA
authors.lastname: Vasconcelos
authors.forename: D da Silva
authors.initials: Dda S
authors.lastname: Ferreira
authors.forename: M L
authors.initials: ML
authors.lastname: Andrade e Silva
authors.forename: R Cassio Sola
authors.initials: RC
authors.lastname: Veneziani
authors.forename: W R
authors.initials: WR
authors.lastname: Cunha
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D008297:Male; D035322:Melastomataceae / Q000737:chemistry*; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D012997:Solvents