Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats.
The seed powder of Datura metel was tested for its hypoglycemic activity in normal and alloxan-induced diabetic rats. Graded doses (25, 50 and 75 mg/kg, p.o.) of the seed powder when given to both normal and diabetic rats produced significant reduction in blood glucose at the 8 h. The effect was found to be dose dependent with all treatments at the doses administered.
Krishna Murthy
B
B
Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India.
Nammi
S
S
Kota
M K
MK
Krishna Rao
R V
RV
Koteswara Rao
N
N
Annapurna
A
A
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D032302:Datura; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D028321:Plant Preparations