title: Is early-pregnancy proteinuria associated with an increased rate of preeclampsia in women with pregestational diabetes mellitus?
abstract: OBJECTIVE
  The purpose of this study was to determine whether the rate of preeclampsia in pregnant diabetic women is increased in those women with early-pregnancy proteinuria of 190 to 499 mg/24 hours compared with women with proteinuria of <190 mg/24 hours.
  
  
  METHODS
  Secondary analysis was performed with relevant data from 194 pregnant women with type 1 and type 2 diabetes mellitus whose condition required insulin and who were enrolled previously in a multicenter trial of low-dose aspirin for the prevention of preeclampsia. The women were assigned to 1 of 3 groups, based on the level of proteinuria at enrollment (13-26 weeks of gestation). Group 1 comprised women with <190 mg protein/24 hours (n=94); group 2 comprised women with 190 to 499 mg protein/24 hours (n=35); and group 3 comprised women with >/=500 mg protein/24 hours (n=65). The rate of preeclampsia, according to strict predefined criteria, was then determined.
  
  
  RESULTS
  The rate of preeclampsia was not increased statistically significantly in patients with early-pregnancy proteinuria of 190 to 499 mg/24 hours (7/35 women; 20%) when compared with women with proteinuria of <190 mg/24 hours (16/94 women; 17%).
  
  
  CONCLUSIONS
  We did not find an increased rate of preeclampsia in women with pregestational diabetes mellitus with early-pregnancy proteinuria of 190 to 499 mg/24 hours when compared with women with pregestational diabetes mellitus with proteinuria of <190 mg/24 hours.
authors.affiliation: National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units, Bethesda, MD, USA.
authors.forename: Helen Y
authors.initials: HY
authors.lastname: How
authors.forename: Baha
authors.initials: B
authors.lastname: Sibai
authors.forename: Marshall
authors.initials: M
authors.lastname: Lindheimer
authors.forename: Steve
authors.initials: S
authors.lastname: Caritis
authors.forename: John
authors.initials: J
authors.lastname: Hauth
authors.forename: Mark
authors.initials: M
authors.lastname: Klebanoff
authors.forename: Cora
authors.initials: C
authors.lastname: Macpherson
authors.forename: Peter
authors.initials: P
authors.lastname: Van Dorsten
authors.forename: Menachem
authors.initials: M
authors.lastname: Miodovnik
authors.forename: Mark
authors.initials: M
authors.lastname: Landon
authors.forename: Richard
authors.initials: R
authors.lastname: Paul
authors.forename: Paul
authors.initials: P
authors.lastname: Meis
authors.forename: Gary
authors.initials: G
authors.lastname: Thurnau
authors.forename: Mitchell
authors.initials: M
authors.lastname: Dombrowski
authors.forename: James
authors.initials: J
authors.lastname: Roberts
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D011225:Pre-Eclampsia / Q000150:complications* / Q000453:epidemiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011254:Pregnancy in Diabetics / Q000150:complications*; D011507:Proteinuria / Q000150:complications* / Q000503:physiopathology; D012720:Severity of Illness Index