[Analysis on clinical and immunohistochemical characteristics of primary extranodular non-Hodgkin's lymphoma in otolaryngol head and neck].
OBJECTIVE
To study the characteristic of clinical manifestation and cell immunophenotype in cases with primary extra-nodular non-Hodgkin's lymphoma (PE-NHL) in otolaryngol head and neck for early diagnosis and treatment.


METHODS
Clinical manifestation of one hundred and fifty five patients with PE-NHL in otolaryngol head and neck from 1991 to 2000 were analyzed and restudied by pathological sections with immunohistochemical technology.


RESULTS
The age of twenty six to fifty years old was the most common age range in the group of patients with PE-NHL. Waldeyer's ring was the most commonly involved site (92 cases), the rest were in sinonasal (57 cases), in laryngopharynx (2 cases) and in larynx (4 cases). There were no characteristic symptoms of primary lesion located. The lump or fester signs were mostly observed on primary position. Cell immunophenotype result displayed 46.4% of the PE-NHL originating from T cells, while 53.6% originating from B cell. Most of waldeyer's PE-NHL originating from B cell, while most of sinonasal PE-NHL originating from T cell.


CONCLUSIONS
The clinical behavior in patients with the PE-NHL is complicated and lacks characterisic symptoms, so the diagnosis is difficult. Doctor should be alert and the repeated exact biopsy may be needed. The diagnosis can be definite by pothological and immunohistochemical approaches with clinical manifestation.
Zhou
Jianrong
J
Department of Otolaryngology, First Affiliated Hospital, Chongqing University of Medical Science, Chongqing 400016.
Wei
Lianzhi
L
Cao
Youde
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy