title: Effect of Kuibitang on lipopolysaccharide-induced cytokine production in peripheral blood mononuclear cells of chronic fatigue syndrome patients.
abstract: Kuibitang (KBT) is clinically used to treat patients suffering from chronic fatigue syndrome (CFS) in South Korea. However, its effect has not been investigated experimentally. Recent reports have shown that CFS patients display an altered cytokine production. We examined the effect of KBT on lipopolysaccharide (LPS)-induced various cytokines production in peripheral blood mononuclear cells (PBMC) of CFS patients and healthy controls. KBT (1 mg/ml) significantly inhibited LPS-induced tumor necrosis factor-alpha, interleukin-10, and transforming growth factor-beta1 production in PBMC of CFS patients. However, LPS-induced interferon-gamma production was significantly increased by KBT (0.01 mg/ml). These results provide evidence of a novel activity of the KBT that regulate cytokines production related with CFS.
authors.affiliation: Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Nyeon-Hyoung
authors.initials: NH
authors.lastname: An
authors.forename: Yun-Jin
authors.initials: YJ
authors.lastname: Cha
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Shin
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Shin
authors.forename: Seung-Hwa
authors.initials: SH
authors.lastname: Baek
authors.forename: Cheorl-Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Yeung-Su
authors.initials: YS
authors.lastname: Lyu
authors.forename: Eon-Jeong
authors.initials: EJ
authors.lastname: Lee
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*; D004306:Dose-Response Relationship, Immunologic; D015673:Fatigue Syndrome, Chronic / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D020835:Medicine, Kampo; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D018709:Statistics, Nonparametric
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D008070:Lipopolysaccharides; D010936:Plant Extracts