Isolation and anticomplement activity of compounds from Dendropanax morbifera.
Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrhea. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. Of these, compound 1 showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98 microM, whereas compounds 2-7 were inactive.
Park
Bo-Young
BY
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-600, South Korea.
Min
Byung-Sun
BS
Oh
Sei-Ryang
SR
Kim
Jung-Hee
JH
Kim
Tae-Jin
TJ
Kim
Dong-Hee
DH
Bae
Ki-Hwan
KH
Lee
Hyeong-Kyu
HK
D027481:Araliaceae; D003169:Complement Inactivator Proteins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves
D003169:Complement Inactivator Proteins; D010936:Plant Extracts; C012749:anticomplement