SNC 80 and related delta opioid agonists.
The discovery of the selective delta (delta) opioid agonists SNC 80 and BW373U86, which possess a diarylmethylpiperazine structure unique among opioids, was a major advance in the field of delta-opioid ligands. Much research has been performed to uncover the structure-activity relationships (SAR) of this class of ligands and also to compare the diarylmethylpiperazines with the traditional morphinan-based delta opioids. This review focuses on the development of the SAR of this unique series of ligands, and discusses questions which remain unanswered.
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Center for Drug Evaluation and Research, Food and Drug Administration, 5600 Fishers Lane, Rockville, MD 20857, USA. CALDERONS@cder.fda.gov
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D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis / Q000494:pharmacology*; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D017465:Receptors, Opioid, delta / Q000819:agonists*; D013329:Structure-Activity Relationship; D014326:Tropanes / Q000138:chemical synthesis / Q000494:pharmacology
D001549:Benzamides; D010879:Piperazines; D010880:Piperidines; D017465:Receptors, Opioid, delta; D014326:Tropanes; C083877:BW 373U86; C088464:4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide