Angiogenesis-related growth factors in brain tumors.
Numerous growth factors have been implicated in glioma angiogenesis. This chapter focuses on the role of scatter factor/hepatocyte growth factor, fibroblast growth factor, platelet-derived growth factor and transforming growth factor beta. We review the expression pattern of these factors in gliomas, their functional contribution to tumor angiogenesis - also in relation to vascular endothelial growth factor, and the effects resulting from their inhibition or overexpression in gliomas in vivo.
Lamszus
Katrin
K
Department of Neurosurgery, University Hospital Hamburg-Eppendorf Germany.
Heese
Oliver
O
Westphal
Manfred
M
D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology*; D002455:Cell Division; D018450:Disease Progression; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005910:Glioma / Q000098:blood supply* / Q000473:pathology*; D006133:Growth Substances / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D008024:Ligands; D009389:Neovascularization, Pathologic; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
D006133:Growth Substances; D008024:Ligands; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D017228:Hepatocyte Growth Factor