Bull's-eye maculopathy associated with quinacrine therapy for malaria.
OBJECTIVE
To report a side effect of quinacrine therapy for malaria.


METHODS
Case report.


METHODS
Review of clinical chart and photographs.


METHODS
Private retina practice.


RESULTS
A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.


CONCLUSIONS
Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.
Browning
David J
DJ
Charlotte Eye, Ear, Nose, and Throat Associates, Charlotte, North Carolina 28210, USA. djbrowining@carolina.rr.com
D000962:Antimalarials / Q000009:adverse effects*; D004596:Electroretinography; D005451:Fluorescein Angiography; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011796:Quinacrine / Q000009:adverse effects*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D014792:Visual Acuity
D000962:Antimalarials; D011796:Quinacrine