title: Hypogammaglobulinemia in pediatric ICU patients.
abstract: The authors retrospectively review their experience with low immunoglobulin G (IgG) levels in a pediatric ICU population over a 12-month period. The total IgG level was below the normal for age in 14 of the 20 patients. The 14 patients with a low IgG level were younger and weighed less when compared with the 6 patients who had a normal IgG level. There was no difference in the risk of mortality between the 2 groups. In the 14 patients with an IgG level less than normal for age, the IgG level was 33% to 99% of normal, with 4 patients having a level less than 50% of normal for their age. Prospective trials are needed to determine the incidence of this problem, its impact on survival, and the appropriate therapy in the pediatric ICU population.
authors.affiliation: Departments of Child Health and Anesthesiology, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, Missouri 65212, USA.
authors.forename: Saif
authors.initials: S
authors.lastname: Rehman
authors.forename: Daniel
authors.initials: D
authors.lastname: Bytnar
authors.forename: John W
authors.initials: JW
authors.lastname: Berkenbosch
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D017677:Age Distribution; D001835:Body Weight; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D003422:Critical Care / Q000379:methods; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric / Q000706:statistics & numerical data; D008923:Missouri / Q000453:epidemiology; D009102:Multiple Organ Failure / Q000150:complications; D009404:Nephrotic Syndrome / Q000150:complications; D012016:Reference Values; D012128:Respiratory Distress Syndrome / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous