title: CGH analysis shows genetic similarities and differences in atypical fibroxanthoma and undifferentiated high grade pleomorphic sarcoma.
abstract: BACKGROUND
  Atypical fibroxanthoma (AFX) and undifferentiated high grade pleomorphic sarcoma (UpS) are histologically very similar, if not identical. However, they differ significantly in clinical outcome.
  
  
  METHODS
  We used comparative genomic hybridization (CGH) to screen 24 AFX and 12 UpS for genomic alterations.
  
  
  RESULTS
  DNA copy number changes were observed in 20/24 AFX and in all UpS. The most frequent alterations occurring with comparable frequency in both tumors were deletions on chromosomes 9p and 13q. We also detected statistically significant differences of genetic alterations between the two tumors concerning deletions on 1q, 3p, 5q, 11p, 11q, gains on 7q, 12q and high level gains on 5p and 11q.
  
  
  CONCLUSIONS
  Despite their very similar histology, AFX and UpS show clear differences in their genetic alterations. This might contribute to the different biological behavior of the two tumors. On the other hand the similarities in genetic alterations on chromosomes 9p and 13q might suggest a common pathogenetic pathway.
authors.affiliation: Department of Pathology, University Hospital, Zürich, Switzerland. daniela.mihic@pty.usz.ch
authors.forename: Daniela
authors.initials: D
authors.lastname: Mihic-Probst
authors.forename: Jianming
authors.initials: J
authors.lastname: Zhao
authors.forename: Parvin
authors.initials: P
authors.lastname: Saremaslani
authors.forename: Angela
authors.initials: A
authors.lastname: Baer
authors.forename: Christian
authors.initials: C
authors.lastname: Oehlschlegel
authors.forename: Bruno
authors.initials: B
authors.lastname: Paredes
authors.forename: Paul
authors.initials: P
authors.lastname: Komminoth
authors.forename: Philipp U
authors.initials: PU
authors.lastname: Heitz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000235:genetics / Q000473:pathology; D009693:Nucleic Acid Hybridization; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm