title: Hypertension, hypertensive heart disease and perioperative cardiac risk.
abstract: The evidence for an association between hypertensive disease, elevated admission arterial pressure, and perioperative cardiac outcome is reviewed. A systematic review and meta-analysis of 30 observational studies demonstrated an odds ratio for the association between hypertensive disease and perioperative cardiac outcomes of 1.35 (1.17-1.56). This association is statistically but not clinically significant. There is little evidence for an association between admission arterial pressures of less than 180 mm Hg systolic or 110 mm Hg diastolic and perioperative complications. The position is less clear in patients with admission arterial pressures above this level. Such patients are more prone to perioperative ischaemia, arrhythmias, and cardiovascular lability, but there is no clear evidence that deferring anaesthesia and surgery in such patients reduces perioperative risk. We recommend that anaesthesia and surgery should not be cancelled on the grounds of elevated preoperative arterial pressure. The intraoperative arterial pressure should be maintained within 20% of the best estimate of preoperative arterial pressure, especially in patients with markedly elevated preoperative pressures. As a result, attention should be paid to the presence of target organ damage, such as coronary artery disease, and this should be taken into account in preoperative risk evaluation. The anaesthetist should be aware of the potential errors in arterial pressure measurements and the impact of white coat hypertension on them. A number of measurements of arterial pressure, obtained by competent staff (ideally nursing staff), may be required to obtain an estimate of the "true" preoperative arterial pressure.
authors.affiliation: Academic Unit of Anaesthesia, University of Leeds, Leeds General Infirmary, Leeds LS1 3EX, UK. s.howell@leeds.ac.uk
authors.forename: S J
authors.initials: SJ
authors.lastname: Howell
authors.forename: J W
authors.initials: JW
authors.lastname: Sear
authors.forename: P
authors.initials: P
authors.lastname: Foëx
mesh_terms: D000758:Anesthesia / Q000379:methods; D001145:Arrhythmias, Cardiac / Q000209:etiology; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology*; D003327:Coronary Disease / Q000209:etiology; D006331:Heart Diseases / Q000209:etiology / Q000628:therapy; D006760:Hospitalization; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000628:therapy; D007431:Intraoperative Complications / Q000209:etiology* / Q000628:therapy; D007511:Ischemia / Q000209:etiology; D012307:Risk Factors; D016896:Treatment Outcome