Coordinating morphogenesis: epithelial integrity during heart tube assembly.
Formation of the embryonic heart tube requires the medial migration and merger of bilateral precursor populations. A new study of zebrafish cardiogenesis published in this issue of Developmental Cell indicates that precursor migration involves formation of a coherent epithelium and that fibronectin plays an important role in maintaining cardiac epithelial integrity.
Glickman
Nathalia S
NS
Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Yelon
Deborah
D
D000818:Animals; D004625:Embryo, Nonmammalian; D004847:Epithelial Cells / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology*; D009206:Myocardium / Q000166:cytology*; D015027:Zebrafish