Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer.
The FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gene. The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein. We have analyzed 254 subjects included in 14 sub-populations. The occurrence of the SNP varies with the ethnicity of the population, suggesting that this SNP could be a valuable biomarker for population genetics. It is most prevalent in various Asian populations (T allele frequency>0.54), followed by the Canadian polar Inuit (T allele frequency=0.3), African American (T allele frequency=0.17), and Caucasian population (T allele frequency=0.1). Since nasopharyngeal carcinoma (NPC) is frequent in Southern China, Taiwan, Borneo and polar Canada, we further tested for the possible association of the FUS2 SNP with this form of endemic cancer. Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention.
Duh
Fuh-Mei
FM
Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA.
Fivash
Matthew
M
Moody
Michele
M
Li Lung
Maria
M
Guo
Xiang
X
Stanbridge
Eric
E
Dean
Michael
M
Voevoda
Michael
M
Hu
Li-Fu
LF
Kashuba
Vladimir
V
Zabarovsky
Eugene R
ER
Qian
Chao-Nan
CN
Godbole
Sharad
S
Tean Teh
Bin
B
Lerman
Michael I
MI
D000123:Acetyltransferases / Q000235:genetics* / Q000502:physiology; D001208:Asia / Q000453:epidemiology / Q000208:ethnology; D002893:Chromosomes, Human, Pair 3; D019353:Endemic Diseases; D005787:Gene Frequency; D016147:Genes, Tumor Suppressor; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D017434:Protein Structure, Tertiary
D000123:Acetyltransferases; C492867:NAA80 protein, human