[Expression of testosterone in the rapid growing rat condylar cartilage and the expression changes after the function mandibular advancement].
OBJECTIVE
To investigate the expressions of Testosterone in the condylar cartilage of rapid growing rats.


METHODS
The mimic functional appliances were used in experiment groups and rats were killed after 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks. Immunohistochemical technique was used to detect the expression of T.


RESULTS
T was expressed throughout the condylar cartilage. The Highest expressions were in mature layers of both experiment and control groups. Along with the maturation, the expressions of T in the condylar cartilage were changed respectively, and the immunostain levels in the mature layer of experiment groups 2 and 3 weeks were higher than those of control groups (P < 0.05).


CONCLUSIONS
1. T is a member of cartilage growth and development control system. 2. The orthopedic mechanism of functional appliance may be conducted by T.
Li
Xiao-bin
XB
Dept. of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Chen
Kai-yun
KY
Zhou
Zheng
Z
Luo
Song-jiao
SJ
D000818:Animals; D002356:Cartilage / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D019186:Mandibular Advancement; D008335:Mandibular Condyle / Q000254:growth & development / Q000378:metabolism*; D017289:Orthodontic Appliances, Functional; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone