A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice.
The mammalian, highly amiloride-sensitive epithelial sodium channel (ENaC) is member of the degenerin/ENaC superfamily of ion channels known to be implicated in sodium homeostasis, mechanosensation, and mechanoperception. A novel role for ENaC implicated in differentiation processes in skin reshapes our current view of this ancient transmembrane channel protein.
Guitard
Marjorie
M
Départment de Pharmacologie et de Toxicologie, Université de Lausanne, CH-1005 Lausanne, Switzerland.
Leyvraz
Celine
C
Hummler
Edith
E
D000818:Animals; D053503:Epithelial Sodium Channels; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D012867:Skin / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000235:genetics* / Q000378:metabolism*
D053503:Epithelial Sodium Channels; D015222:Sodium Channels; D012964:Sodium