The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer.
At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05), but less for leptin in the cancer group (P<0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer.
Barber
M D
MD
University Department of Surgery, Royal Infirmary, Edinburgh EH3 9YW, UK.
McMillan
D C
DC
Wallace
A M
AM
Ross
J A
JA
Preston
T
T
Fearon
K C H
KC
D001786:Blood Glucose; D004032:Diet; D004734:Energy Metabolism; D005223:Fats / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood* / Q000494:pharmacology; D020738:Leptin / Q000097:blood* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010190:Pancreatic Neoplasms / Q000473:pathology*; D015431:Weight Loss / Q000502:physiology*
D001786:Blood Glucose; D005223:Fats; D015850:Interleukin-6; D020738:Leptin; D006854:Hydrocortisone