Neuronal development: putting motor neurons in their place.
In the developing spinal cord, motor neurons occupy discrete columns with different identities and axon projections. This organisation has now been shown to depend crucially on sequential phases of expression of Hox-c proteins, generated in response to fibroblast growth factor signals.
Guthrie
Sarah
S
MRC Centre for Developmental Neurobiology, 4th Floor New Hunt's House, King's College, Guy's Campus, London SE1 1UL, UK.
D000818:Animals; D019521:Body Patterning; D005346:Fibroblast Growth Factors / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000378:metabolism*; D009046:Motor Neurons / Q000166:cytology / Q000378:metabolism*; D015398:Signal Transduction; D013116:Spinal Cord / Q000196:embryology*
D018398:Homeodomain Proteins; D005346:Fibroblast Growth Factors