title: Persistent colonization of nine cystic fibrosis patients with an Achromobacter (Alcaligenes) xylosoxidans clone.
abstract: The present study was conducted to investigate the increasing incidence of Achromobacter (previously Alcaligenes) xylosoxidans isolates being recovered from sputum samples of cystic fibrosis patients at a cystic fibrosis department for adults in Athens, Greece. During the 1-year study period, a total of 34 isolates were detected persistently in 9 of 71 cystic fibrosis patients. The isolates exhibited resistance to multiple antimicrobial agents. Isolates that were recovered repeatedly from each patient exhibited identical macrorestriction profiles with pulsed-field gel electrophoresis, indicating that the same strain persisted in the lungs of these patients. Isolates from five of the patients were genetically related, suggesting a common-source outbreak of Achromobacter xylosoxidans colonization or infection.
authors.affiliation: Department of Microbiology, Sismanoglion General Hospital, Athens, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Kanellopoulou
authors.forename: S
authors.initials: S
authors.lastname: Pournaras
authors.forename: H
authors.initials: H
authors.lastname: Iglezos
authors.forename: N
authors.initials: N
authors.lastname: Skarmoutsou
authors.forename: E
authors.initials: E
authors.lastname: Papafrangas
authors.forename: A N
authors.initials: AN
authors.lastname: Maniatis
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000421:Alcaligenes / Q000187:drug effects / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015331:Cohort Studies; D015169:Colony Count, Microbial; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000453:epidemiology*; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D005500:Follow-Up Studies; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D018570:Risk Assessment; D017678:Sex Distribution
chemical_list: D000900:Anti-Bacterial Agents