title: Practical de-O-acylation reactions promoted by molecular sieves.
abstract: Methanol dried extensively over molecular sieves, or methanol in combination with powdered molecular sieves, serves as a good acceptor for acyl transfer reactions. Several O-acetylated and O-benzoylated sugar derivatives were efficiently de-O-acylated using this approach. In the case of per-O-acetylated N-acetylglucosamine, selective anomeric deprotection could be effected in high yield.
authors.affiliation: Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Punjab 160062, India. rkartha@niper.ac.in
authors.forename: K P
authors.initials: KP
authors.lastname: Ravindranathan Kartha
authors.forename: Balaram
authors.initials: B
authors.lastname: Mukhopadhyay
authors.forename: Robert A
authors.initials: RA
authors.lastname: Field
mesh_terms: D000107:Acetylation; D000215:Acylation; D002241:Carbohydrates / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D000432:Methanol / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D002241:Carbohydrates; D000432:Methanol