Novel reaction products from thiobarbituric Acid of biological interest.
The reactions of 1, 2-dihydro-2-thioxo-4, 6(1H, 5H)pyrimidinedione (1) with some pi-deficients have led to the formation of unexpected heterocyclic products such as anilinomethylenethioxopyrimidinedione, 2, 2'-bis(pyrimidinecarbothioamide), allylthioxopyrimidinecarbothioamide, indenopyranopyrimidine and benzofuropyrimidine derivatives. A possible mechanism for the formation of these products is discussed, and the biological activity is determined.
Aly
Ashraf A
AA
Chemistry Department, Faculty of Science, El-Minia University, El-Minia, A.R. Egypt.
Mourad
Aboul-Fetouh E
AF
Hassan
Alaa A
AA
Mohamed
Nasr K
NK
Ali
Bahaa A
BA
El-Sayed
Mohamed M
MM
D000818:Animals; D002470:Cell Survival; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000494:pharmacology; D013858:Thiobarbiturates / Q000138:chemical synthesis* / Q000494:pharmacology; D013871:Thiones / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C486637:6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydroindeno(2',1'-5,6)pyrano(2,3-d)pyrimidine-5-carbonitrile; D006571:Heterocyclic Compounds; D006993:Hypnotics and Sedatives; D011743:Pyrimidines; D013858:Thiobarbiturates; D013871:Thiones; C029684:thiobarbituric acid