title: Diagnostic and therapeutic utility of B-type natriuretic peptide in patients with renal insufficiency and decompensated heart failure.
abstract: Chronic kidney disease (CKD) and congestive heart failure (CHF) are epidemiologically and pathophysiologically linked. A recent study in patients with severe CHF demonstrated that renal plasma flow was inversely correlated with pulmonary capillary wedge pressure, right atrial pressure, pulmonary pressure, and right ventricular ejection fraction. This article reviews the utility of B-type natriuretic peptide (BNP) levels in assessing cardiac function and volume status in patients with CKD and examines the safety and efficacy of BNP therapy in patients with renal insufficiency and decompensated heart failure.
authors.affiliation: Divisions of Cardiology, Nutrition and Preventive Medicine, William Beaumont Hospital, Royal Oak, Michigan, USA.
authors.forename: Peter A
authors.initials: PA
authors.lastname: McCullough
authors.forename: Joseph
authors.initials: J
authors.lastname: Kuncheria
authors.forename: Vandana S
authors.initials: VS
authors.lastname: Mathur
mesh_terms: D000818:Animals; D015897:Comorbidity; D006333:Heart Failure / Q000097:blood* / Q000453:epidemiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000453:epidemiology; D045283:Natriuretic Agents / Q000097:blood / Q000494:pharmacology; D020097:Natriuretic Peptide, Brain / Q000097:blood* / Q000494:pharmacology; D011379:Prognosis; D012039:Regional Blood Flow
chemical_list: D045283:Natriuretic Agents; D020097:Natriuretic Peptide, Brain