Role of nebulized antibiotics for the treatment of respiratory infections.
OBJECTIVE
The purpose of this review is to summarize modern data pertaining to the use of aerosolized antimicrobials for the treatment of and prophylaxis against pulmonary infections.


RESULTS
Few recent publications have examined the safety and efficacy of nebulized antibiotics. Two well conducted trials have been published that describe the utility of tobramycin solution for inhalation among cystic fibrosis patients. A couple of good reviews have also been published that have summarized the use of aerosolized antibiotics in other patient populations.


CONCLUSIONS
Data regarding this topic are scarce. At this time, data support the use of aerosolized tobramycin solution for inhalation in cystic fibrosis patients infected or colonized by Pseudomonas aeruginosa. Apart from this situation, widespread aerosolized administration of other agents in cystic fibrosis and non-cystic fibrosis patient populations should not be advocated.
Klepser
Michael E
ME
Ferris State University, Big Rapids, and Borgess Medical Center, Kalamazoo, Michigan, USA. michaelklepser@ferris.edu
D000280:Administration, Inhalation; D000336:Aerosols; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D006801:Humans; D009330:Nebulizers and Vaporizers; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D014031:Tobramycin / Q000008:administration & dosage
D000336:Aerosols; D000890:Anti-Infective Agents; D014031:Tobramycin