Antidermatophytic activity of extracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound.
Extracts obtained from seeds of Psoralea corylifolia showed several degrees of antifungal activity against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum gypseum by the disc diffusion method on a Sabouraud dextrose agar (SDA) medium. Methanol extract of the seeds at 250 microg exhibited the maximum inhibition with a halo of 28 mm diameter. Six different bands were obtained when the methanol extract was subjected to TLC. 13C NMR and Mass spectra revealed that the active compound would be a flavonoid, 4'-methoxy flavone. MIC of the active compound along with standard miconazole was carried out using tube dilution technique.
Rajendra Prasad
N
N
Department of Biochemistry, Annamalai University, Annamalainagar 608 002, Tamilnadu, India.
Anandi
C
C
Balasubramanian
S
S
Pugalendi
K V
KV
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029907:Psoralea; D012639:Seeds
C487850:4'-methoxyflavone; D000935:Antifungal Agents; D005419:Flavonoids; D010936:Plant Extracts