Identification of rTid-1, the rat homologue of the drosophila tumor suppressor l(2)tid gene.
Active cell death ('apoptosis' or 'programmed cell death') is essential in the development and homeostasis of multicellular organisms and abnormal inhibition of apoptosis is an indicator of cancer and autoimmune diseases, whereas excessive cell death is implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Here we demonstrate new isoforms of the rat homologue of the drosophila tumor suppressor l(2)tid gene (rTid-1). Moreover, we show that rTid-1 interacts isoform-specifically with the heat-shock-cognate-glucose-regulated protein hscGRP75 and neither induces nor inhibits directly neuronal apoptosis. This finding points to a pivotal role of Tid-1 in the control of cellular survival.
Fujita
Masako
M
BF Research Institute, National Cardiovascular Center, Suita, Osaka, Japan.
Nagai
Yasuo
Y
Sawada
Tohru
T
Heese
Klaus
K
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D002460:Cell Line; D029721:Drosophila Proteins / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D024101:Mitochondrial Proteins; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017385:Sequence Homology
C093721:CG5504 protein, Drosophila; D029721:Drosophila Proteins; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D024101:Mitochondrial Proteins; D020033:Protein Isoforms; C080352:mortalin; C493318:rTid-1 protein, rat