Multiple pathways for telomere tethering: functional implications of subnuclear position for heterochromatin formation.
Technical advances in the imaging of GFP derivatives in living cells have improved our ability to determine the position and dynamics of specific chromatin loci. This approach, combined with genetics and functional assays, has shed new light on how nuclear compartments facilitate gene repression in yeast.
Taddei
Angela
A
Department of Molecular Biology, University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland.
Gasser
Susan M
SM
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D022003:Cell Nucleus Structures / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D007399:Interphase / Q000235:genetics; D008967:Molecular Biology / Q000379:methods; D012091:Repetitive Sequences, Nucleic Acid; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000378:metabolism; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D016615:Telomere / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D006570:Heterochromatin; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D014157:Transcription Factors; C079591:ESC1 protein, S pombe; C081647:high affinity DNA-binding factor, S cerevisiae