The effects of 5-HT on feeding behaviour in mianserin- or cyproheptadine-pretreated rats.
We examined the effects of 5-HT on the feeding behaviour patterns of rats pretreated with mianserin (5-HT(1B/2A/1D receptor antagonist) or cyproheptadine (a 5-HT(2c) receptor antagonist), injected into the pariventricular hypothalamus nucleus (PVN). The animals were kept at 21 +/- 1 degrees C with a 12 h light and 12 h dark cycle on a self-selected feeding paradigm, and provided with freely available and separate sources of proteins, carbohydrates, fats and water. The results indicate that the suppressive effect of 5-HT on carbohydrate intake can be blocked by mianserin and cyproheptadine even at the onset of the natural (dark) feeding period; however, this is a distinct blockade in the paradigm of feeding behavior. All of the meal patterns of fat intake and rest remained unaffected.
Mancilla-Díaz
J M
JM
Neurobiology of Eating Laboratory, Universidad Nacional Autónoma de México, FES, Iztacala, México. jmmd@servidor.unam.mx
Escartín-Pérez
R E
RE
López-Alonso
V E
VE
D000704:Analysis of Variance; D000818:Animals; D003533:Cyproheptadine / Q000494:pharmacology*; D004040:Dietary Carbohydrates; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D004040:Dietary Carbohydrates; D012702:Serotonin Antagonists; D008803:Mianserin; D003533:Cyproheptadine; D012701:Serotonin