title: [Unitary-core osmotic pump tablet for controlled release of water-insoluble drug].
abstract: OBJECTIVE
  To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.
  
  
  METHODS
  Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.
  
  
  RESULTS
  Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.
  
  
  CONCLUSIONS
  Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.
authors.affiliation: College of Pharmaceutical Science, Zhejiang University, Hangzhou 310027, China. liulx@zju.edu.cn
authors.forename: Long-xiao
authors.initials: LX
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Xu
authors.forename: Gilson
authors.initials: G
authors.lastname: Khang
authors.forename: John-moon
authors.initials: JM
authors.lastname: Rhee
authors.forename: Hai-bang
authors.initials: HB
authors.lastname: Lee
mesh_terms: D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D009543:Nifedipine / Q000008:administration & dosage* / Q000737:chemistry; D009995:Osmosis; D011092:Polyethylene Glycols / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D013607:Tablets; D011092:Polyethylene Glycols; D011189:Potassium Chloride; D009543:Nifedipine