title: The ageing of the blood supply and the lymphatic drainage of the skin.
abstract: The anatomy and functions of the blood and lymph vessels of human skin are described. Variation in these due to site, ageing and events during life consequent to exposure to a threatening environment are emphasised. Gradual atrophy and greater heterogeneity are features of ageing. Responses to injury and repair are complex and the interaction of mechanical signals distorting skin cells with numerous chemical signals are referred to. The lymphatics are part of an immunosurveillance system to monitor skin barrier penetration. The review attempts to draw attention to key recent advances in our understanding of the cytokine and growth factor production of the skin in the context of previous mainly physiological reviews especially influenced by 50 years of clinical practice as a dermatologist with an eye on both the skin and the fields of microcirculation and lymphology.
authors.affiliation: Churchill Hospital, Oxford, UK. oxfordwound@aol.com
authors.forename: Terence
authors.initials: T
authors.lastname: Ryan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017951:Antigen Presentation; D001284:Atrophy; D004730:Endothelium, Vascular / Q000276:immunology / Q000502:physiology; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007156:Immunologic Memory; D007509:Irritants / Q000009:adverse effects; D008208:Lymphatic System / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D015166:Monitoring, Immunologic; D018384:Oxidative Stress; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D015595:Skin Aging / Q000473:pathology / Q000502:physiology*; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology; D014666:Vasomotor System / Q000503:physiopathology; D014945:Wound Healing / Q000502:physiology
chemical_list: D007509:Irritants; D042461:Vascular Endothelial Growth Factor A