title: [Synthesis and antitumor activity of the derivatives of cephalotaxine and drupacine].
abstract: OBJECTIVE
  To make full use of cephalotaxus plant resources and search for antitumor agents with higher activities and lower side effects.
  
  
  METHODS
  The C3 hydroxy groups of the cephlotaxine and drupacine were acylated by taxol side chain and its isomers to give a series of derivatives of cephlotaxine and drupacine.
  
  
  RESULTS
  Six novel alkaloid esters were designed and synthesized. The pharmacological screening results showed that VIIIa, VIIIb, IXa and IXc exhibited significant activities on KB, HCT and Bel in vitro.
  
  
  CONCLUSIONS
  Novel alkaloid esters are worthy to be intensively studied.
authors.affiliation: Institute of Materia Medica Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100050, China. xianrongye@imm.ac.cn
authors.forename: Xian-rong
authors.initials: XR
authors.lastname: Ye
authors.forename: Ke-mei
authors.initials: KM
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D006248:Harringtonines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000077863:Homoharringtonine; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D008113:Liver Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006248:Harringtonines; C007562:drupacine; D000077863:Homoharringtonine