title: Quantitative measurement of histamine H(1) receptors in human brains by PET and [11C]doxepin.
abstract: The aim of this study is to establish a method for quantitative measurement of histamine H(1) receptor (H1R) in human brain by PET and [(11)C]doxepin ([(11)C]DOX). The estimated parameters with a two-compartment model were stable for the initial values for parameter estimation but those with a three-compartment model were not. This finding suggests that the H1R measured by the [(11)C]DOX and PET can be evaluated with a two-compartment model.
authors.affiliation: Department of Phamacology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Keiichi
authors.initials: K
authors.lastname: Oda
authors.forename: Toru
authors.initials: T
authors.lastname: Sasaki
authors.forename: Manabu
authors.initials: M
authors.lastname: Tashiro
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yanai
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D001931:Brain Mapping / Q000379:methods; D003198:Computer Simulation; D004316:Doxepin / Q000493:pharmacokinetics*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008959:Models, Neurological; D049268:Positron-Emission Tomography / Q000379:methods; D011865:Radioisotope Dilution Technique; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D011969:Receptors, Histamine H1; D004316:Doxepin