title: An evaluation of Ki-67 and PCNA expression in conjunctival and eyelid tumours.
abstract: The aim of our study was an evaluation of the expression of cell proliferation markers (PCNA and Ki-67) in conjunctival and eyelid papillomas and squamous and basal cell cancers. A series of 9 cases of squamous cell cancer (SCC), 15 cases of basal cell cancer (BCC) and 43 cases of squamous cell papilloma (SCP) were assessed using the immunohistochemical method with monoclonal antibodies. PCNA overexpression was observed in 100% of SCP, in 88.8% of SCC and in 100% of BCC cases. Ki-67 overexpression was seen in 32.5% of cases of SCP, in 22.2% of SCC and in 66.6% of BCC. The results showed that an evaluation of Ki-67 expression is the most valuable cell proliferation marker.
authors.affiliation: Department of Pathology, Medical University, Białystok, Poland. joasia@zpk.amb.edu.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Reszeć
authors.forename: Luiza
authors.initials: L
authors.lastname: Kańczuga-Koda
authors.forename: Mariola
authors.initials: M
authors.lastname: Sulkowska
authors.forename: Mariusz
authors.initials: M
authors.lastname: Koda
authors.forename: Jacek
authors.initials: J
authors.lastname: Cylwik
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Barwijuk-Machała
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sulkowski
mesh_terms: D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000378:metabolism / Q000473:pathology; D005134:Eye Neoplasms / Q000378:metabolism* / Q000473:pathology; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D010212:Papilloma / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen