title: Immune regulation by self-reactive T cells is antigen specific.
abstract: Immune regulation plays an important role in the establishment and maintenance of self-tolerance. Nevertheless, it has been difficult to conclude whether regulation is Ag specific because studies have focused on polyclonal populations of regulatory T cells. We have used in this study a murine transgenic model that generates self-reactive, regulatory T cells of known Ag specificity to determine their capacity to suppress naive T cells specific for other Ags. We show that these regulatory cells can regulate the responses of naive T cells with the same TCR specificity, but do not inhibit T cell proliferation or differentiation of naive T cells specific for other Ags. These results demonstrate that immune regulation may be more Ag specific than previously proposed.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale Unité 591, Centre Hospitalo-Universitaire Necker, Paris, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Tanchot
authors.forename: Florence
authors.initials: F
authors.lastname: Vasseur
authors.forename: Christiane
authors.initials: C
authors.lastname: Pontoux
authors.forename: Corinne
authors.initials: C
authors.lastname: Garcia
authors.forename: Adelaida
authors.initials: A
authors.lastname: Sarukhan
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000235:genetics / Q000276:immunology*; D024201:Bystander Effect / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002455:Cell Division / Q000235:genetics / Q000276:immunology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D018984:Epitopes, T-Lymphocyte / Q000235:genetics / Q000276:immunology*; D007399:Interphase / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D012261:Ribonucleoproteins / Q000235:genetics / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D000097585:SS-B Antigen
chemical_list: D001324:Autoantigens; D016207:Cytokines; D018984:Epitopes, T-Lymphocyte; D016693:Receptors, Antigen, T-Cell, alpha-beta; D015375:Receptors, Interleukin-2; D012261:Ribonucleoproteins; D000097585:SS-B Antigen