Blastic CD56+ natural killer-cell lymphoma with primary cutaneous manifestation.
T/natural killer-cell lymphomas belong to a heterogeneous group of non-Hodgkin lymphomas with predominant extranodal, often cutaneous, manifestations. In contrast to B- and T-cell lymphomas, T/NK-cell lymphomas were only recently regarded as a distinct entity. These rather aggressive malignancies arise from cytotoxic T cells, NK-cells or NK-like T cells, which share several phenotypic and functional properties. We report a man with a blastic NK-cell lymphoma with nodular skin infiltrations as the leading clinical manifestation of the disease. Complicated of tuberculosis, the patient died within 9 months of diagnosis, despite aggressive polychemotherapy.
Berger
Thomas G
TG
Department of Dermatology, University Hospital of Erlangen, Erlangen, Germany. thomas.berger@derma.imed.uni-erlangen.de
Voll
Reinhard E
RE
Simon
Miklos
M
Kiesewetter
Franklin
F
D000368:Aged; D019002:CD56 Antigen / Q000032:analysis*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
D019002:CD56 Antigen