title: The clinical free radical scavenger, edaravone, protects cochlear hair cells from acoustic trauma.
abstract: It is known that reactive oxygen species have toxicity to the cochlea. We investigated the effect of edaravone, a free radical scavenger for clinical use, on the cochleae of guinea pigs subjected to acoustic trauma. We assessed auditory brainstem response (ABR) thresholds to evaluate cochlear function and observed the sensory epithelium. After noise exposure (130 dB SPL, 3 h), we observed that the auditory brainstem response threshold shift in edaravone-treated ears was significantly less than that in untreated ears. This result suggests that edaravone protected the cochleae from acoustic trauma.
authors.affiliation: Department of Otolaryngology, Yamaguchi University School of Medicine, Minamikogushi 1-1-1, Ube, Yamaguchi 755-8505, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takemoto
authors.forename: Kazuma
authors.initials: K
authors.lastname: Sugahara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Okuda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimogori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003051:Cochlea / Q000293:injuries* / Q000473:pathology; D004343:Drug Implants; D000077553:Edaravone; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000293:injuries* / Q000473:pathology; D018072:Hair Cells, Auditory, Outer / Q000293:injuries / Q000473:pathology; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000517:prevention & control*; D009622:Noise / Q000009:adverse effects; D009925:Organ of Corti / Q000473:pathology
chemical_list: D004343:Drug Implants; D016166:Free Radical Scavengers; D000077553:Edaravone; D000983:Antipyrine