[Livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome].
A 64-year-old male patient presented with painful ulcerations and livedo racemosa of both lower limbs. He had a history of cerebral and myocardial infarctions. Dermatohistologic findings and laboratory tests of the patient's coagulation system revealed the diagnosis of livedoid vasculopathy with heterozygous factor V Leiden mutation and sticky platelet syndrome type II. Systemic treatment with acetylsalicylic acid and heparin as well as topical therapy with disinfectant and granulation-inducing agents resulted in improvement of the skin lesions.
Lewerenz
V
V
Hautklinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
Burchardt
T
T
Büchau
A
A
Ruzicka
T
T
Megahed
M
M
D020016:Activated Protein C Resistance; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets; D005165:Factor V / Q000235:genetics*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006579:Heterozygote; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D017354:Point Mutation; D012867:Skin / Q000473:pathology; D017445:Skin Diseases, Vascular / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; C095381:factor V Leiden; D005165:Factor V; D006493:Heparin; D001241:Aspirin