title: Total cholesterol correlates with cyclosporine C2 levels in kidney transplant recipients under maintenance immunosuppression.
abstract: The aim of this study was to assess the relationship between cyclosporine (CyA) trough level (C0) and 2-hour postdose (C2) and total cholesterol (TC) in kidney transplant (KT) recipients on Neoral maintenance immunosuppression. In KT recipients who had more than 5 years of follow-up, stable graft function, and stable Neoral dose, we measured C2 and C0 blood levels, serum creatinine, mean total cholesterol (TC) over the last 5 years, prednisone dose, use of beta-blockers and thiazides. Correlations between C0 and C2 levels and TC were performed with the Pearson coefficient. Receiver operating characteristics (ROCs) were used to define the threshold with greater accuracy for significant variables at the correlation test. Statistical tests were performed with SPSS 9.5 The C2 correlated with TC (0.31; P=.008) whereas C0 did not. The C2 level was an independent predictor for TC after adjusting for recipient age, gender, dose of prednisone, creatinine clearance, and use of beta-blockers and thiazides (B coefficient=1.124(E-3); P=.009). A threshold C2 value of 700 microg/L yielded to a TC level of 5.2 mmol/L. This is the first study to report a correlation between C2 levels and TC. Although C2 explained a small fraction of TC variability, it is an independent predictor of TC in KT recipients on Neoral maintenance immunosuppression. A long-term C2 value under 700 microg correlates with better control of hypercholesterolemia.
authors.affiliation: Division of Nephrology, CHUM, Hôpital Notre-Dame, Montreal, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Cardinal
authors.forename: A A
authors.initials: AA
authors.lastname: Barama
authors.forename: V
authors.initials: V
authors.lastname: Fradet
authors.forename: M
authors.initials: M
authors.lastname: Lallier
authors.forename: R
authors.initials: R
authors.lastname: Lévesque
authors.forename: G
authors.initials: G
authors.lastname: St Louis
authors.forename: M J
authors.initials: MJ
authors.lastname: Hébert
authors.forename: C
authors.initials: C
authors.lastname: Girardin
authors.forename: M
authors.initials: M
authors.lastname: Pâquet
authors.forename: P
authors.initials: P
authors.lastname: Daloze
mesh_terms: D002784:Cholesterol / Q000097:blood*; D016572:Cyclosporine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D016572:Cyclosporine; D002784:Cholesterol