title: Use of cystatin C determination in clinical diagnostics.
abstract: This paper presents a current view of the possible clinical uses of cystatin C determination. Cystatin C is an inhibitor of cysteine proteases, and relatively stable in the systemic circulation it is comparatively easily determined. Although in clinical practice it is known primarily as a relatively reliable and endogenous marker for glomerular filtration, lately cystatin C analysis has been discussed in connection with the diagnostics of a variety of diseases such as early atherosclerosis, Alzheimer's dementia, vascular aneurysms, hyperhomocysteinaemia and other neurodegenerative diseases.
authors.affiliation: Clinic of Neurology, Teaching Hospital, Olomouc, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Mares
authors.forename: David
authors.initials: D
authors.lastname: Stejskal
authors.forename: Jitka
authors.initials: J
authors.lastname: Vavrousková
authors.forename: Karel
authors.initials: K
authors.lastname: Urbánek
authors.forename: Roman
authors.initials: R
authors.lastname: Herzig
authors.forename: Petr
authors.initials: P
authors.lastname: Hlustík
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling; D002493:Central Nervous System Diseases / Q000175:diagnosis; D055316:Cystatin C; D015891:Cystatins / Q000032:analysis*; D006801:Humans
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins