Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats.
To determine the possible involvement of N-methyl-d-aspartate (NMDA) and muscarinic activation of the perirhinal cortex in object recognition, an NMDA antagonist (d,l-2-amino-5-phosphonopentanoic acid (AP5)) and a muscarinic antagonist (scopolamine) were injected into the perirhinal cortex of rats. A high dose of AP5 (60 mM) and two doses of scopolamine (20 and 80 mM), but not a low dose of AP5 (30 mM) alone, significantly impaired discrimination between novel and familiar objects in a spontaneous object recognition task, which is one of the recognition memory tasks. These results suggest that activation of both NMDA and muscarinic receptors in the perirhinal cortex contributes to object recognition.
Abe
Hiroshi
H
Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki 889-1692, Japan. abehiro@med.miyazaki-u.ac.jp
Ishida
Yasushi
Y
Iwasaki
Tsuneo
T
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D002755:Choice Behavior / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans; D011976:Receptors, Muscarinic / Q000502:physiology*; D021641:Recognition, Psychology / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology
D018691:Excitatory Amino Acid Antagonists; D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D015763:2-Amino-5-phosphonovalerate; D012601:Scopolamine