title: Evaluation of hypoglycemic and antihyperglycemic effects of Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats.
abstract: The seed powder of Datura metel was tested for its hypoglycemic activity in normal and alloxan-induced diabetic rats. Graded doses (25, 50 and 75 mg/kg, p.o.) of the seed powder when given to both normal and diabetic rats produced significant reduction in blood glucose at the 8 h. The effect was found to be dose dependent with all treatments at the doses administered.
authors.affiliation: Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, Andhra Pradesh, India.
authors.forename: B
authors.initials: B
authors.lastname: Krishna Murthy
authors.forename: S
authors.initials: S
authors.lastname: Nammi
authors.forename: M K
authors.initials: MK
authors.lastname: Kota
authors.forename: R V
authors.initials: RV
authors.lastname: Krishna Rao
authors.forename: N
authors.initials: N
authors.lastname: Koteswara Rao
authors.forename: A
authors.initials: A
authors.lastname: Annapurna
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D032302:Datura; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D028321:Plant Preparations