Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats.
The preventive effect of teprenone (6,10,14,18-teramethyl-5,9,13,17-nonadecatetaene-2-one), an anti-ulcer drug, on acute gastric mucosal lesion progression was examined in rats with a single intraperitoneal (i.p.) injection of compound 48/80 (0.75 mg/kg). Teprenone (20, 100 or 200 mg/kg), which was orally administered 0.5 h after compound 48/80 treatment at which time gastric mucosal lesions appeared, prevented gastric mucosal lesion development at 3 h after the treatment dose-dependently. Gastric mucosal tissues of compound 48/80-treated rats showed increases in myeloperoxidase (an index of neutrophil infiltration) and xanthine oxidase activities and thiobarbituric acid reactive substances (an index of lipid peroxidation) content and decreases in Se-glutathione peroxidase activity and hexosamine and vitamin E contents at 3 h after the treatment. Post-administered teprenone attenuated all these changes dose-dependently. These results indicate that teprenone prevents acute gastric mucosal lesion progression in compound 48/80-treated rats possibly by suppressing gastric mucus depletion, neutrophil infiltration and oxidative stress in the gastric mucosal tissue.
Ohta
Yoshiji
Y
Department of Chemistry, School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Japan. yohta@fujita-hu.ac.jp
Kobayashi
Takashi
T
Inui
Kazuo
K
Yoshino
Junji
J
Kitagawa
Akira
A
Nakazawa
Saburo
S
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004224:Diterpenes / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000098:blood supply / Q000201:enzymology / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D006632:Histamine / Q000097:blood; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000097:blood; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine
D000897:Anti-Ulcer Agents; D004224:Diterpenes; D006595:Hexosamines; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D012701:Serotonin; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D009195:Peroxidase; D005979:Glutathione Peroxidase; D014969:Xanthine Oxidase; C031049:geranylgeranylacetone