[Antagonistic effect of sodium ferulate on glycerol-induced renal oxidative injury in mice].
OBJECTIVE
To investigate the effect of sodium ferulate (SF) on glycerol-induced renal injury.


METHODS
Glycerol solution 50% was injected intramuscularly to establish a model of acute tubular necrosis in mice. SF was administered intraperitoneally at the dose of 100-200 mg.kg-1 at the beginning of establishing the model and its effect was observed by monitoring renal function, antioxidative functions and renal pathologic histology.


RESULTS
At 6 and 72 h after glycerol injection, SF treatment (100-200 mg.kg-1) showed significant and dose-dependent antagonistic actions on the increment of blood urea nitrogen (BUN), creatinine (Cr), and N-acetyl-beta-glucosaminidase (NAG) induced by glycerol. The increase of renal malondialdehyde (MDA) content and the decrease of glutathione content, glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), catalase (Cat) and superoxide dismutase (SOD) activities resulting from glycerol injection were remarkably inversed by SF at the dose of 200 mg.kg-1. Meanwhile, improvement of the renal histology was observed as well.


CONCLUSIONS
SF showed beneficial effect on glycerol-induced acute tubular necrosis due to its antioxidative action.
Liao
Zhang-xiu
ZX
Department of Pharmacology, Medical College, Wuhan University, Wuhan 430071, China.
Wang
Hui
H
Peng
Ren-xiu
RX
Kong
Rui
R
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D003373:Coumaric Acids / Q000494:pharmacology*; D003404:Creatinine / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D005990:Glycerol; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D007677:Kidney Function Tests; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D003373:Coumaric Acids; D008315:Malondialdehyde; C004999:ferulic acid; D003404:Creatinine; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005990:Glycerol