Association between the interleukin-1beta C(-511)T polymorphism and blood pressure in a Chinese hypertensive population.
The interleukin-1beta (IL-1beta) is an important pro-inflammatory cytokine in a broad spectrum of physiological processes. Previous investigations have observed that levels of the IL-1beta were higher in essential hypertensive patients and the IL-1beta gene polymorphism has been shown to be related to IL-1 production. We hypothesized that genetically determined differences in activity or responsiveness of cytokine(s) might contribute to hypertension. In this report, we utilized a family-based design to test the association between the IL-1beta C(-511)T polymorphism and blood pressure levels in hypertensive patients chosen from rural communities in Anhui, China. In men, carriers of the IL-1beta (-511)*C allele were found to have lower systolic (P = 0.049) blood pressure levels compared with T homozygotes, which conforms to an additive effect model. By contrast, no significant association between the IL-1beta gene and blood pressure levels was revealed in women. Our results suggested a significant role of the IL-1beta C(-511)T polymorphism in the control of blood pressure in Chinese hypertensives.
Huang
Guo
G
School of Life Sciences, University of Science and Technology of China, Hefei.
Niu
Tianhua
T
Peng
Shaojie
S
Ling
Daijun
D
Liu
Jing
J
Zhang
Xuejun
X
Xu
Xiping
X
D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D003596:Cytosine / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007375:Interleukin-1 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012727:Sex Characteristics; D013941:Thymine / Q000378:metabolism
D007375:Interleukin-1; D003596:Cytosine; D013941:Thymine