title: Deoxynucleic guanidine; synthesis and incorporation of purine nucleosides into positively charged DNG oligonucleotides.
abstract: The synthesis of purine nucleosides capable of making the guanidinium linkage is described for the first time starting from the corresponding 2'-deoxynucleosides. The positively charged mixed base DNG oligomer containing guanine was synthesized on solid-phase using CPG as support from 3' to 5' direction using the precursor building block nucleosides.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA.
authors.forename: Hemavathi
authors.initials: H
authors.lastname: Challa
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Bruice
mesh_terms: D004247:DNA / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006146:Guanidines; D011684:Purine Nucleosides; C088820:deoxynucleic guanidine; D004247:DNA