[A study of fluoride and dexamethasone affecting the proliferation in osteoblast].
OBJECTIVE
Investigate the effects of low dose of fluoride and dexamethasone on the proliferation of MC3T3-E1 osteoblast cell line in vitro, which was for determining the possible effects of fluoride and dexamthasone affecting the development and differentiation of osteoblast.


METHODS
Observe the growing shape of MC3T3-E1 osteoblast cultured in vitro, and investigate the effects of low dose of fluoride and dexamethasone on the proliferation of osteoblast by cell count.


RESULTS
MC3T3-E1 osteoblast grew stably. The cells in D group increased obviously in the early stage of the cell culture, however the cells in F group had no tendency of increasing during the whole culture.


CONCLUSIONS
In vitro low doses of dexamethasone may promote the proloferation of osteoblast precursors,however,low dose of fluoride has no effect on promoting proliferation of MC3T3-E1 osteoblast.
Ge
L H
LH
Department of Oral Medicine, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China.
Zhang
W G
WG
Shu
R
R