title: Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.
abstract: 3,7-Diarylsubstituted imidazopyridines were designed and developed as a new class of KDR kinase inhibitors. A variety of imidazopyridines were synthesized and potent inhibitors of KDR kinase activity were identified with good aqueous solubility.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA. zhicai_wu@merck.com
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Wu
authors.forename: Mark E
authors.initials: ME
authors.lastname: Fraley
authors.forename: Mark T
authors.initials: MT
authors.lastname: Bilodeau
authors.forename: Mildred L
authors.initials: ML
authors.lastname: Kaufman
authors.forename: Edward S
authors.initials: ES
authors.lastname: Tasber
authors.forename: Adrienne E
authors.initials: AE
authors.lastname: Balitza
authors.forename: George D
authors.initials: GD
authors.lastname: Hartman
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Coll
authors.forename: Keith
authors.initials: K
authors.lastname: Rickert
authors.forename: Jennifer
authors.initials: J
authors.lastname: Shipman
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
authors.forename: Laura
authors.initials: L
authors.lastname: Sepp-Lorenzino
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Thomas
mesh_terms: D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D012995:Solubility; D013329:Structure-Activity Relationship; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D011725:Pyridines; D040301:Vascular Endothelial Growth Factor Receptor-2