title: Antiplasmodial constituents of Cajanus cajan.
abstract: Bioactivity-guided fractionation of extracts of roots and leaves of Cajanus cajan afforded 8 compounds: betulinic acid, biochanin A, cajanol, genistein and 2'-hydroxygenistein, longistylin A and C, and pinostrobin. The two stilbenes, longistylin A and C, and betulinic acid showed a moderately high in vitro activity against the chloroquine-sensitive Plasmodium falciparum strain 3D7.
authors.affiliation: Chemistry Department, University of Ghana, Legon, Accra, Ghana.
authors.forename: George
authors.initials: G
authors.lastname: Duker-Eshun
authors.forename: Jerzy W
authors.initials: JW
authors.lastname: Jaroszewski
authors.forename: William A
authors.initials: WA
authors.lastname: Asomaning
authors.forename: Francis
authors.initials: F
authors.lastname: Oppong-Boachie
authors.forename: S
authors.initials: S
authors.lastname: Brøgger Christensen
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D036561:Cajanus; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts