title: A statistical treatment of biases affecting the estimation of mutation rates.
abstract: We consider the estimation of mutation rates, using family data obtained from disputed paternity cases. It is shown how to take appropriate account of a number of complicating features-in particular, hidden mutation, differential mutation, and uncertain paternity-which can necessitate large corrections to simple estimates.
authors.affiliation: Dipartimento di Economia, Università Roma Tre, Via Ostiense 139, 00154 Roma, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Vicard
authors.forename: A P
authors.initials: AP
authors.lastname: Dawid
mesh_terms: D000483:Alleles; D015982:Bias; D005260:Female; D005554:Forensic Medicine / Q000379:methods; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D010334:Paternity; D010375:Pedigree; D011336:Probability; D020080:Tandem Repeat Sequences / Q000235:genetics