[Thyrotoxic hypokalaemic periodic paralysis in a Caucasian male].
We report the case of a caucasian patient with a presentation of a periodic paralysis associated with hypokalaemia disclosing Graves' disease. Major pathophysiologics hypothesis are discused in order to explain relationships between hyperthyroidism and paralysis through a disturbance of the excitability of the muscle fibres. A genetic predisposition explain the high incidence of this affection in asiatic population while it is uncommon in caucasian race. Potassium supplementation is not needed in order to correct hypokalaemia except in case of cardiac disturbances. Treatment by beta-blockers is advisable with the specific treatment of hyperthyroidism.
Lionet
A
A
Service de néphrologie, Centre hospitalier de Dunkerque.
Barsumau
J
J
Azar
R
R
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics; D002231:Carbimazole / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D020514:Hypokalemic Periodic Paralysis / Q000208:ethnology / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D007473:Ion Channels / Q000502:physiology; D008297:Male; D008564:Membrane Potentials; D009119:Muscle Contraction / Q000502:physiology; D011433:Propranolol / Q000627:therapeutic use; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis / Q000502:physiology; D013963:Thyroid Hormones / Q000502:physiology; D013971:Thyrotoxicosis / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D044465:White People / Q000235:genetics
D000319:Adrenergic beta-Antagonists; D013956:Antithyroid Agents; D007473:Ion Channels; D013963:Thyroid Hormones; D002231:Carbimazole; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase