[Soluble HLA class I and HLA class II antigens in the blood of HIV infected patients].
The levels of HLA, class I, antigen and HLA-DR antigen in the blood sera of HIV-infected persons were determined by the enzyme immunoassay. The levels of soluble antigens HLR-DR and of HLA, class I, in serum samples containing only antibodies to HIV were elevated, respectively, 1.8- and 1.3-fold in comparison with the norm. The level of soluble HLA-DR antigen in samples containing the markers of other infections (HBsAg, antibodies to hepatitis C virus, anti-IgM antibodies to cytomegalovirus) was significantly higher in comparison with samples containing only antibodies to HIV and serum samples from healthy donors (p < 0.05). The concentration of soluble HLA antigen, class I, in the samples containing antibodies to HIV and markers of other infections was also elevated, but the statistically authentic increase in comparison with the normal level was observed only in the presence of the markers of HIV infection, hepatitis C and cytomegalovirus infection.
Khudiakova
N E
NE
Blokhina Research Institute of Epidemiology and Microbiology, Lobachevsky State University, Nizhny Novgorod, Russia.
Novikov
V V
VV
Kravchenko
G A
GA
Ivanova
N I
NI
Ptitsyna
Iu S
IuS
Nosov
N N
NN
D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006684:HLA-DR Antigens / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000150:complications; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D000949:Histocompatibility Antigens Class II / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D012995:Solubility
D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II