title: Biological studies of radiolabeled glucose analogues iodinated in positions 3, 4 or 6.
abstract: The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-standard tracer of glucose uptake, 2-deoxy-D-glucose. None of these molecules had the same biological behavior than 2-deoxy-D-glucose. Therefore, these compounds cannot be considered as tracers of glucose uptake.
authors.affiliation: Radiopharmaceutiques Biocliniques, INSERM E03 40, Université Joseph Fourier, 38000 Grenoble, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Perret
authors.forename: Catherine
authors.initials: C
authors.lastname: Ghezzi
authors.forename: Lionel
authors.initials: L
authors.lastname: Ogier
authors.forename: Medhi
authors.initials: M
authors.lastname: Abbadi
authors.forename: Christophe
authors.initials: C
authors.lastname: Morin
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Mathieu
authors.forename: Daniel
authors.initials: D
authors.lastname: Fagret
mesh_terms: D017667:Adipocytes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D004912:Erythrocytes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose