title: Sex difference in the effect of ACE-DD genotype on the risk of premature myocardial infarction.
abstract: In this association study the authors compared the insertion/deletion (I/D) angiotensin-I converting enzyme (ACE) gene polymorphism in females and males with premature myocardial infarction (MI). I/D ACE gene polymorphism was tested in 738 subjects: 302 patients with MI (151 men and 151 women) and 436 healthy subjects (207 men and 229 women). In women the ACE-DD genotype was not associated with MI (OR 1.1, 95% CI 0.6-2.1, p=0.6), whereas the ACE-DD genotype conferred a 2-fold independent risk for MI in men (95% CI=1.2-3.4; p=0.013) after adjustment for cardiovascular risk factors. The authors found evidence for the sex difference in the effect of the ACE-DD genotype on MI risk. The ACE-DD genotype conferred a 2-fold independent risk for premature MI in males.
authors.affiliation: Institute of Histology and Embryology, Medical Faculty, University of Ljubljana, Slovenia. daniel.petrovic@mf.uni-lj.si
authors.forename: Daniel
authors.initials: D
authors.lastname: Petrovic
authors.forename: Dejan
authors.initials: D
authors.lastname: Bregar
authors.forename: Barbara
authors.initials: B
authors.lastname: Guzic-Salobir
authors.forename: Erik
authors.initials: E
authors.lastname: Skof
authors.forename: Matjaz
authors.initials: M
authors.lastname: Span
authors.forename: Rifet
authors.initials: R
authors.lastname: Terzić
authors.forename: Mojca Globocnik
authors.initials: MG
authors.lastname: Petrovic
authors.forename: Irena
authors.initials: I
authors.lastname: Keber
authors.forename: Mitja
authors.initials: M
authors.lastname: Letonja
authors.forename: Marjeta
authors.initials: M
authors.lastname: Zorc
authors.forename: Matej
authors.initials: M
authors.lastname: Podbregar
authors.forename: Borut
authors.initials: B
authors.lastname: Peterlin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D007703:Peptidyl-Dipeptidase A