Parecoxib for parenteral analgesia in postsurgical patients.
OBJECTIVE
To review the pharmacology, pharmacokinetics, clinical efficacy and safety studies, adverse effects, drug interactions, and dosage and administration of parecoxib sodium, a selective cyclooxygenase-2 (COX-2) inhibitor.


METHODS
Information was obtained from MEDLINE searches of the English-language literature (1996-May 2003). Search terms included parecoxib, parecoxib sodium, SC-69124A, and selective cyclooxygenase-2 inhibitor.


METHODS
We reviewed available literature, which included abstracts, clinical trials, and data on file with the manufacturer.


RESULTS
Parecoxib sodium is a novel selective COX-2 inhibitor under development for parenteral administration. It has produced efficacious analgesia following dental, gynecologic, and orthopedic surgery. The adverse effect profile has been compared with that of ketorolac; no statistically significant differences were identified. There are no documented drug interactions when parecoxib is coadministered with midazolam, propofol, or unfractionated heparin.


CONCLUSIONS
Parecoxib sodium is in the final stages of Phase III trials and has a favorable safety and efficacy profile. Its place in moderate to severe postsurgical pain management will be further defined when more pharmacoeconomic and postmarketing safety data are available. Theoretical benefits are its lower potential for gastrointestinal adverse effects compared with ketorolac and lower opioid requirements after surgery.
Amabile
Celene M
CM
Maricopa Integrated Health System, Phoenix, AZ 85008, USA. celene.amabile@hcs.maricopa.gov
Spencer
Anne P
AP
D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007555:Isoxazoles / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic
D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; C409945:parecoxib