title: Laser surface modification of silicone rubber to reduce platelet adhesion in vitro.
abstract: To improve the blood compatibility, the surface of polydimethylsiloxane (PDMS) films were irradiated using a CO2-pulsed laser. Acrylamide (AAm) was grafted onto a pre-irradiated surface. The AAm-grafted and laser-treated films were characterized using different techniques. Platelet adhesion and activation onto the AAm-grafted PDMS, laser-treated (ungrafted) and unmodified PDMS film surfaces were compared. Data from in vitro assays indicated that the platelet adhesion was reduced on the AAm-grafted PDMS and laser treated PDMS films in comparison with the unmodified PDMS. The laser-irradiated sample showed the minimum platelet adhesion. It seems that laser irradiation onto a silicone rubber surface is a versatile technique to produce anti-thrombogenic surface for biomaterial applications.
authors.affiliation: Biomaterial Department, Iran Polymer and Petrochemical Institute, PO Box 14185/0515, Tehran, IR of Iran. m.khorasani@proxy.ipi.ac.ir
authors.forename: M T
authors.initials: MT
authors.lastname: Khorasani
authors.forename: H
authors.initials: H
authors.lastname: Mirzadeh
mesh_terms: D020106:Acrylamide / Q000737:chemistry; D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry; D001593:Benzyl Compounds / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D006801:Humans; D007834:Lasers; D008855:Microscopy, Electron, Scanning; D010545:Peroxides / Q000032:analysis / Q000737:chemistry; D015539:Platelet Activation; D010973:Platelet Adhesiveness; D010976:Platelet Count; D012826:Silicone Elastomers / Q000737:chemistry*; D012828:Silicones / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties / Q000528:radiation effects; D017155:Wettability; D000099166:Polyacrylamides
chemical_list: D020106:Acrylamide; D000180:Acrylic Resins; D001593:Benzyl Compounds; D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D010545:Peroxides; D012826:Silicone Elastomers; D012828:Silicones; D000099166:Polyacrylamides; C013830:baysilon; C037517:dicumyl peroxide