title: Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices.
abstract: Glycerol monooleate (GMO) matrix was found to be a gastro-retentive carrier system suitable for both polar and as well as non-polar drugs. Chlorpheniramine maleate (CPM) and diazepam (DZP) were used as model drugs. Effect of PEG 4000, PEG 10000, and stearic acid on floatability and release profile was studied. Water uptake increased with increase in the loading of polar drug (CPM) and decreased with non-polar drug (DZP). Similar effect was found to occur in case of drug release. PEGs increased the release up to certain concentration and decreased thereafter. Drug release decreased linearly with concentration of stearic acid. The type and extent of mesophases formed were significantly affected by the nature of drug, excipients and their concentration. Thus the selection of suitable excipients depending on polarity of drug, could help to modulate the floatability and release profile from GMO matrices.
authors.affiliation: Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandawane, Pune 411038, Maharashtra State, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Kumar M
authors.forename: Manish H
authors.initials: MH
authors.lastname: Shah
authors.forename: Anant
authors.initials: A
authors.lastname: Ketkar
authors.forename: K R
authors.initials: KR
authors.lastname: Mahadik
authors.forename: Anant
authors.initials: A
authors.lastname: Paradkar
mesh_terms: D002626:Chemistry, Pharmaceutical; D002744:Chlorpheniramine / Q000737:chemistry; D003975:Diazepam / Q000737:chemistry; D004304:Dosage Forms; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D013229:Stearic Acids / Q000737:chemistry; D013997:Time Factors
chemical_list: D004304:Dosage Forms; D004337:Drug Carriers; D005079:Excipients; D005989:Glycerides; D013229:Stearic Acids; D002744:Chlorpheniramine; D011092:Polyethylene Glycols; C031183:stearic acid; C005953:monoolein; D003975:Diazepam