title: Drug targets: turning the channel (on) for sedation.
abstract: Genetic techniques have recently implicated two different ion channels as critical molecular targets for the sedative action of ethanol and intravenous anesthetics. In each case, the target is hyperactivated by the drug.
authors.affiliation: NIH, NIMH, Bldg 36, Rm 1B08, MSC 4034, 9000 Rockville Pike Bethesda, Maryland 20892, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Sandstrom
authors.forename: Howard
authors.initials: H
authors.lastname: Nash
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D018118:Chloride Channels / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D051036:Large-Conductance Calcium-Activated Potassium Channels; D009154:Mutation / Q000235:genetics; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects*; D040641:Quantitative Trait Loci / Q000235:genetics
chemical_list: D018686:Anesthetics, Intravenous; D002492:Central Nervous System Depressants; D018118:Chloride Channels; D051036:Large-Conductance Calcium-Activated Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D000431:Ethanol