title: In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance program.
abstract: We examined the in vitro activities of voriconazole, posaconazole, and fluconazole against 3,932 isolates of Candida spp. and 237 isolates of Cryptococcus neoformans obtained from over 100 medical centers worldwide during 2001 and 2002. The MICs of the antifungal drugs were determined by broth microdilution tests performed according to the National Committee for Clinical Laboratory Standards (NCCLS) methods using RPMI 1640 as the test medium. Voriconazole and posaconazole were very active against Candida spp. (97-98% susceptible at MICs < or =1 microg/ml) and C. neoformans (98-100% susceptible at MICs < or =1 microg/mL). C. albicans (MIC90, 0.015-0.03 microg/ml) was the most susceptible species of Candida to both agents and C. glabrata (MIC90, 1-2 microg/mL) was the least susceptible. Both voriconazole and posaconazole were more active than fluconazole against all Candida spp. and C. neoformans. These results provide further evidence for the increased spectrum and potency of the new triazoles against a large and geographically diverse collection of opportunistic fungal pathogens.
authors.affiliation: Department of Pathology, University of Iowa College of Medicine, Iowa City, IA, USA. michael-pfaller@uiowa.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Pfaller
authors.forename: S A
authors.initials: SA
authors.lastname: Messer
authors.forename: L
authors.initials: L
authors.lastname: Boyken
authors.forename: R J
authors.initials: RJ
authors.lastname: Hollis
authors.forename: C
authors.initials: C
authors.lastname: Rice
authors.forename: S
authors.initials: S
authors.lastname: Tendolkar
authors.forename: D J
authors.initials: DJ
authors.lastname: Diekema
mesh_terms: D002175:Candida / Q000145:classification / Q000187:drug effects*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000302:isolation & purification; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D014943:Global Health; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D015337:Multicenter Studies as Topic; D011336:Probability; D011743:Pyrimidines / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; C101425:posaconazole; D015725:Fluconazole; D065819:Voriconazole