Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities.
Novel antibiotics named kigamicin A, B, C, D, and E were discovered from the culture broth of Amycolatopsis sp. ML630-mF1 by their selective killing activity against PANC-1 cells only under a nutrient starved condition. Under a condition of nutrient starvation, kigamicins A, B, C, and D inhibited PANC-1 cell survival at 100 times lower concentration than in normal culture. Kigamicins showed antimicrobial activity against Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). Kigamicin D inhibited the growth of various mouse tumor cell lines at IC50 of about 1 microg/ml.
Kunimoto
Setsuko
S
Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. kunimotos@bikaken.or.jp
Lu
Jie
J
Esumi
Hiroyasu
H
Yamazaki
Yohko
Y
Kinoshita
Naoko
N
Honma
Yoshiko
Y
Hamada
Masa
M
Ohsono
Michiyo
M
Ishizuka
Masaaki
M
Takeuchi
Tomio
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D005658:Fungi / Q000737:chemistry / Q000648:ultrastructure; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D051379:Mice; D008855:Microscopy, Electron, Scanning; D010080:Oxazoles / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
D000903:Antibiotics, Antineoplastic; D010080:Oxazoles; C484116:kigamicin A; C484115:kigamicin B; C484114:kigamicin C; C484110:kigamicin D; C484112:kigamicin E; D004317:Doxorubicin