Genome scan for loci linked to mite sensitivity: the Collaborative Study on the Genetics of Asthma (CSGA).
Mite sensitivity has been reported to be a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome scan using mite reactivity (Dermatophagoides Pteronyssinus (Der p) and Dermatophagoides farinae (Der f)) as the phenotype was conducted. In 287 CSGA families, 122 were informative for linkage. Evidence supporting linkage was observed for regions on chromosome 19 (D19S591, lod=2.43, P=0.0008; D19S1037, lod=1.57, P=0.007) and chromosome 20 (D20S473/D20S604, lod=1.41, P=0.01). All three ethnic groups appeared to contribute to the evidence for linkage on chromosome 20. African-American families gave strongest support for linkage on chromosomes 3 (D3S2409, lod=1.33, P=0.01), 12 (D12S373, lod=1.51, P=0.008) and 18 (ATA82B02, lod=1.32, P=0.01). Caucasian families showed strong evidence for linkage on chromosome 19 (D19S591, lod=3.51, P=0.00006). Hispanic families supported linkage on chromosomes 11 (D11S1984, lod=1.56, P=0.007), 13 (D13S787, lod=1.30, P=0.01) and 20 (D20S470, lod=1.71, P=0.005). These results suggest that multiple genes may be involved in controlling skin reactivity to Dermatophoigoies.
Blumenthal
M N
MN
Department of Medicine, University of Minnesota, Minneapolis, MN, USA. blume001@tc.umn.edu
Ober
C
C
Beaty
T H
TH
Bleecker
E R
ER
Langefeld
C D
CD
King
R A
RA
Lester
L
L
Cox
N
N
Barnes
K
K
Togias
A
A
Mathias
R
R
Meyers
D A
DA
Oetting
W
W
Rich
S S
SS
D000818:Animals; D039741:Antigens, Dermatophagoides / Q000378:metabolism; D001249:Asthma / Q000208:ethnology / Q000235:genetics* / Q000276:immunology*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D004198:Disease Susceptibility; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008126:Lod Score; D008297:Male; D008925:Mites / Q000276:immunology*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012882:Skin Tests
D039741:Antigens, Dermatophagoides