title: Neuroretinitis in patients with multiple sclerosis.
abstract: OBJECTIVE
  To present a case series of three patients with neuroretinitis associated with multiple sclerosis.
  
  
  METHODS
  Retrospective, noncomparative, consecutive, interventional case series.
  
  
  METHODS
  Thirty-five consecutive patients with neuroretinitis.
  
  
  METHODS
  The records of 35 consecutive patients with neuroretinitis were reviewed for prior, concurrent, or subsequent development of multiple sclerosis.
  
  
  METHODS
  Presentation, clinical course, and diagnosis of multiple sclerosis.
  
  
  RESULTS
  Three of 35 patients (8.6%) with neuroretinitis were diagnosed with multiple sclerosis by the McDonald criteria. One of the three patients underwent brain biopsy that further confirmed multiple sclerosis. Neuroretinitis in the three patients occurred after the diagnosis of multiple sclerosis. All three patients with multiple sclerosis had been treated with interferon beta before or concurrently with the development of neuroretinitis.
  
  
  CONCLUSIONS
  Neuroretinitis can be an associated manifestation of multiple sclerosis. The possible association between neuroretinitis and interferon beta warrants further investigation.
authors.affiliation: Neuro-Ophthalmology Unit, Mason Eye Institute, University of Missouri-Columbia, Columbia, Missouri 65212, USA. JohnsonLN@health.missouri.edu
authors.forename: Kyle E
authors.initials: KE
authors.lastname: Williams
authors.forename: Lenworth N
authors.initials: LN
authors.lastname: Johnson
mesh_terms: D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012173:Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012189:Retrospective Studies; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D008775:Methylprednisolone