title: [Interleukin-5 regulate the bone marrow response in the model of allergic rhinitis].
abstract: OBJECTIVE
  To elucidate the mechanism of bone marrow response regulated by interleukin-5 (IL-5) in the model of allergic rhinitis.
  
  
  METHODS
  Twenty SD rats were randomly divided into allergic rhinitis (AR) group and control group. The leucocytes in the smears of bone marrow and peripheral blood were counted, and the expression of IL-5 was detected by immunohistochemistry.
  
  
  RESULTS
  The ratio of eosinophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of basophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of eosinophils to white cells in peripheral blood smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of IL-5 positive cells to white cells in bone marrow smears of AR group was significantly higher than that of control group (P < 0.05). The ratio of IL-5 positive cells to white cells was significantly positively correlated with the ratio of eosinophils to white cells in bone marrow smears of AR group (R = 0.85, P < 0.01).
  
  
  CONCLUSIONS
  IL-5 regulates the proliferation and differentiation of eosinophils in bone marrow.
authors.affiliation: Beijing Tongren Center of Otorhinolaryngology Head-Neck Surgery, Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China. entwxd@vip.sina.com
authors.forename: Xiang-dong
authors.initials: XD
authors.lastname: Wang
authors.forename: De-min
authors.initials: DM
authors.lastname: Han
authors.forename: Bing
authors.initials: B
authors.lastname: Zhou
authors.forename: Yong-xiang
authors.initials: YX
authors.lastname: Wei
authors.forename: Wen-zhong
authors.initials: WZ
authors.lastname: Bai
authors.forename: Zhong-yan
authors.initials: ZY
authors.lastname: Liu
authors.forename: Shu-ying
authors.initials: SY
authors.lastname: Ju
mesh_terms: D000818:Animals; D001491:Basophils / Q000473:pathology; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology*; D002452:Cell Count; D004804:Eosinophils / Q000473:pathology; D015848:Interleukin-5 / Q000378:metabolism / Q000502:physiology*; D008297:Male; D010047:Ovalbumin; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*
chemical_list: D015848:Interleukin-5; D010047:Ovalbumin