title: Cerebral metabolism in male patients with schizophrenia who have seriously and dangerously violently offended: a 31P magnetic resonance spectroscopy study.
abstract: There is biochemical evidence to suggest that membrane phospholipid metabolism may be impaired in some patients with schizophrenia. The aim of this study was to test the hypothesis that patients with schizophrenia who have violently offended while psychotic suffer from changes in cerebral phospholipid metabolism. Cerebral 31-phosphorus magnetic resonance spectroscopy was carried out in 15 male patients with schizophrenia who had violently offended (homicide, attempted murder, or wounding with intent to cause grievous bodily harm) while psychotic and in a control group of 13 age-matched healthy male control subjects. Spectra were obtained from 70x70x70mm(3) voxels in the brain using an image-selected in vivo spectroscopy pulse sequence. betaNTP was lower (P < 0.04) and gammaNTP was higher (P < 0.04) in the patient group compared with the normal control group. Our results are suggestive of increased cerebral energy metabolism taking place in the forensic patients.
authors.affiliation: MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK.
authors.forename: B K
authors.initials: BK
authors.lastname: Puri
authors.forename: S J
authors.initials: SJ
authors.lastname: Counsell
authors.forename: G
authors.initials: G
authors.lastname: Hamilton
authors.forename: M G
authors.initials: MG
authors.lastname: Bustos
authors.forename: D F
authors.initials: DF
authors.lastname: Horrobin
authors.forename: A J
authors.initials: AJ
authors.lastname: Richardson
authors.forename: I H
authors.initials: IH
authors.lastname: Treasaden
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D016022:Case-Control Studies; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism*; D014754:Violence
chemical_list: D008563:Membrane Lipids