title: Molecular imaging of the brain: a historical perspective.
abstract: The rapid expansion of modern molecular imaging methods since the time of their initial conception in the 1970s has given rise to numerous discoveries of molecular mechanisms that underlie brain function in health and disease. Uses in clinical diagnosis and therapy monitoring are still evolving. Future clinical trials, in which molecular imaging is imbedded and correlated with clinical outcomes, will be critical to advancing new uses for patient management. Receptor occupancy studies are already well integrated into many drug development studies and clinical trials; such studies will provide a basis for new studies that will further advance clinical uses of brain molecular imaging.
authors.affiliation: Departments of Radiology and Radiological Services and Neuroscience, Johns Hopkins University School of Medicine, JHOC 3225, 601 North Carolina Street, Baltimore, MD 21287, USA. jfrost@jhmi.edu
authors.forename: J James
authors.initials: JJ
authors.lastname: Frost
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D049673:History, 20th Century; D006801:Humans; D009292:Narcotic Antagonists; D009294:Narcotics / Q000266:history* / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000266:history; D011957:Receptors, Opioid / Q000819:agonists / Q000266:history*; D014055:Tomography, Emission-Computed / Q000266:history* / Q000379:methods
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D019275:Radiopharmaceuticals; D011957:Receptors, Opioid