[Cytokine status of patients with ophthalmic herpes].
Data are reported on the content of pro- and antiinflammatory cytokines in blood serum and lachrymal fluid of 62 patients with ophthalmoherpes. It was concluded that the cytokine profiles are subject to changes in the eye herpes: the IL-6 and IL-4 contents were increasing in blood serum, while IL-1 beta and TNF-alpha were increasing in lachrymal fluid. The content of cytokine in blood serum is different from such content in lachrymal fluid in surface-type and profound variations of ophthalmoherpes. Disbalance of inflammatory IL-1 beta, IL-6, TNF-alpha and IL-4 are typical of the latter case, which can be used clinically to evaluate a disease severity degree.
Mal'khanov
V B
VB
Shevchuk
N E
NE
Marvanova
Z R
ZR
D000328:Adult; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood / Q000378:metabolism*; D016849:Keratitis, Herpetic / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha