Branching morphogenesis and kidney disease.
Branching morphogenesis in the kidney is a tightly regulated, complex process and its disruption potentially can lead to a broad spectrum of diseases, ranging from rare hereditary syndromes to common conditions such as hypertension and chronic kidney failure. This review synthesizes data on branching during kidney development derived from in vitro and in vivo rodent studies and to apply them to human diseases. It discusses how the broad organization of molecular interactions during kidney development might provide a mechanistic framework for understanding disorders related to aberrant branching.
Shah
Mita M
MM
Department of Pediatrics, University of California, San Diego, CA 92093-0693, USA.
Sampogna
Rosemary V
RV
Sakurai
Hiroyuki
H
Bush
Kevin T
KT
Nigam
Sanjay K
SK
D000818:Animals; D004195:Disease Models, Animal; D018507:Gene Expression Regulation, Developmental; D019812:Heparan Sulfate Proteoglycans / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000033:anatomy & histology* / Q000196:embryology* / Q000473:pathology / Q000502:physiology; D015394:Molecular Structure; D009024:Morphogenesis / Q000502:physiology*; D012038:Regeneration / Q000502:physiology
D019812:Heparan Sulfate Proteoglycans