title: Acute coronary syndrome and crystal methamphetamine use: a case series.
abstract: "Ice" is a form of methamphetamine commonly used as a recreational drug in Hawaii and the Philippines, but seldom encountered in the continental United States. It differs in appearance from methamphetamine tablets, but otherwise has exactly the same molecules, only arranged in a crystalline structure. A sizeable body of in vitro, animal, and autopsy data suggest a linkage between methamphetamine use and myocardial pathology. In this report, we describe a series of eight patients who developed unstable angina or acute myocardial infarction in association with smoking crystal methamphetamine. The findings, to a large extent, resemble those with cocaine-associated acute coronary syndromes. Given the widespread abuse of methamphetamine among young age groups, the recognition and primary prevention of cardiovascular toxic effects is of mounting socioeconomic importance.
authors.affiliation: Department of Medicine, University of Hawaii, Honolulu 96813, USA. mevanwijetunga@yahoo.com
authors.forename: Mevan
authors.initials: M
authors.lastname: Wijetunga
authors.forename: Romal
authors.initials: R
authors.lastname: Bhan
authors.forename: Joseph
authors.initials: J
authors.lastname: Lindsay
authors.forename: Steven
authors.initials: S
authors.lastname: Karch
mesh_terms: D000208:Acute Disease; D000328:Adult; D000789:Angina, Unstable / Q000139:chemically induced / Q000175:diagnosis; D000697:Central Nervous System Stimulants / Q000009:adverse effects*; D003327:Coronary Disease / Q000139:chemically induced* / Q000175:diagnosis; D004562:Electrocardiography; D005260:Female; D006254:Hawaii; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D009203:Myocardial Infarction / Q000139:chemically induced / Q000175:diagnosis; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000209:etiology*; D013577:Syndrome
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine