title: Antidermatophytic activity of extracts from Psoralea corylifolia (Fabaceae) correlated with the presence of a flavonoid compound.
abstract: Extracts obtained from seeds of Psoralea corylifolia showed several degrees of antifungal activity against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum gypseum by the disc diffusion method on a Sabouraud dextrose agar (SDA) medium. Methanol extract of the seeds at 250 microg exhibited the maximum inhibition with a halo of 28 mm diameter. Six different bands were obtained when the methanol extract was subjected to TLC. 13C NMR and Mass spectra revealed that the active compound would be a flavonoid, 4'-methoxy flavone. MIC of the active compound along with standard miconazole was carried out using tube dilution technique.
authors.affiliation: Department of Biochemistry, Annamalai University, Annamalainagar 608 002, Tamilnadu, India.
authors.forename: N
authors.initials: N
authors.lastname: Rajendra Prasad
authors.forename: C
authors.initials: C
authors.lastname: Anandi
authors.forename: S
authors.initials: S
authors.lastname: Balasubramanian
authors.forename: K V
authors.initials: KV
authors.lastname: Pugalendi
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029907:Psoralea; D012639:Seeds
chemical_list: C487850:4'-methoxyflavone; D000935:Antifungal Agents; D005419:Flavonoids; D010936:Plant Extracts