[Study on in vitro dissolution rate of geniposide in huangqin qingfei dispersible tablet].
OBJECTIVE
To study in vitro dissolution rate of geniposide in Huangqin Qingfei dispersible tablet.


METHODS
A reversed-phase HPLC method was developed for determination of geniposide. In vitro dissolution rates were compared between Huangqin Qingfei dispersible tablet and conventional tablet in the dissolution medium of pH 1.0, 2.85, 4.5, 6.8, and 8.0 accordingly. Zero-class model, single-index model, logarithm normal school model, and Weibull distributing model were used to simulate the dissolution curve.


RESULTS
The dissolution rate of two tablets is not affected by pH so much, and they can dissolve within 5 to 10 minutes. Weibull distributing model is the best simulation for in vitro dissolution. Comparing with conventional tablet, dispersible tablet dissolve quickly and completely.


CONCLUSIONS
The in vitro dissolution rate of geniposide in Huangqin Qingfei dispersible tablet conforms to Weibull distributing model. The dispersible tablet is able to release rapidly.
Cheng
Yan-jun
YJ
Institute of Cinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700. yanjun-chen@msn.com
Zang
Chen
C
Zhao
Xiao-mei
XM
Feng
Qing-ran
QR
D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000302:isolation & purification; D032062:Gardenia / Q000737:chemistry*; D039823:Iridoids / Q000032:analysis*; D007700:Kinetics; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000032:analysis*; D031363:Scutellaria / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000737:chemistry; D013997:Time Factors
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D039823:Iridoids; D011714:Pyrans; D013607:Tablets; C007835:geniposide