title: Ln(III)-DOTAMGly complexes: a versatile series to assess the determinants of the efficacy of paramagnetic chemical exchange saturation transfer agents for magnetic resonance imaging applications.
abstract: OBJECTIVE
  Paramagnetic Ln-DOTAMGly complexes (Ln not equal La, Lu, and Gd) are the prototypes of a novel class of contrast agents for magnetic resonance imaging based on chemical exchange saturation transfer (CEST). Their ability to reduce the water signal intensity depends on the interplay of several physico-chemical properties of the agent and instrumental parameters. This study aims to identify possible routes for their optimization
  
  
  METHODS
  Saturation transfer (ST) has been measured in vitro at 7.05 T as a function of pH, temperature, and concentration of the agent.
  
  
  RESULTS
  Large saturation transfer effects have been observed upon irradiating the coordinated water protons (for Ln = Pr, Nd, Eu, and Tb). The comparison of the results obtained by irradiating water versus amide protons allows the set-up of ratiometric methods through which the ST response can be made independent on the concentration of the agent.
  
  
  CONCLUSIONS
  The modulation of the magnetic properties along the lanthanide series allows an in-depth understanding of the determinants of ST effect and provides useful insights for the design of more efficient agents.
authors.affiliation: Dipartimento di Chimica IFM, Università di Torino, Torino, Italy.
authors.forename: Enzo
authors.initials: E
authors.lastname: Terreno
authors.forename: Daniela Delli
authors.initials: DD
authors.lastname: Castelli
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Cravotto
authors.forename: Luciano
authors.initials: L
authors.lastname: Milone
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003287:Contrast Media; D028581:Lanthanoid Series Elements / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000737:chemistry; D011522:Protons; D014867:Water / Q000737:chemistry
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D011522:Protons; D014867:Water