7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.
Boschelli
Diane H
DH
Chemical and Screening Sciences and Oncology, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. bosched@wyeth.com
Wang
Yanong D
YD
Johnson
Steve
S
Wu
Biqi
B
Ye
Fei
F
Barrios Sosa
Ana Carolina
AC
Golas
Jennifer M
JM
Boschelli
Frank
F
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D006801:Humans; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D009570:Nitriles; D011804:Quinolines; C426236:ARG tyrosine kinase; D011505:Protein-Tyrosine Kinases; D019061:src-Family Kinases