title: Electrophysiological insights into the mechanism of ion-coupled cotransporters.
abstract: Most ion-coupled cotransporters display, in the absence of organic substrate, transient currents resembling the gating currents of voltage-dependent ion channels. Detailed comparison of these currents in different ionic and temperature conditions with the corresponding steady-state currents when translocation of the substrate occurs reveals new insights into the mechanisms of the process.
authors.affiliation: Laboratory of Cellular and Molecular Physiology, Department of Structural and Functional Biology, and Center for Neurosciences, University of Insubria, 21100 Varese, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Peres
authors.forename: Stefano
authors.initials: S
authors.lastname: Giovannardi
authors.forename: Elena
authors.initials: E
authors.lastname: Bossi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Fesce
mesh_terms: D000818:Animals; D004594:Electrophysiology; D007473:Ion Channels / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology*; D008954:Models, Biological
chemical_list: D007473:Ion Channels