title: Relating biochemistry and function in the myosin superfamily.
abstract: All characterized myosins share a common ATPase mechanism. However, detailed kinetic analyses suggest that modulation of the rate and equilibrium constants that define the ATPase cycle confers specific properties to these motor proteins, suiting them to specific physiological tasks. Understanding the kinetic mechanisms allows potential cellular functions of the different myosin classes and isoforms to be better defined.
authors.affiliation: Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520, USA.
authors.forename: Enrique M
authors.initials: EM
authors.lastname: De La Cruz
authors.forename: E Michael
authors.initials: EM
authors.lastname: Ostap
mesh_terms: D000818:Animals; D007527:Isoenzymes / Q000737:chemistry / Q000145:classification / Q000378:metabolism; D007700:Kinetics; D018995:Myosin Heavy Chains / Q000502:physiology; D009218:Myosins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; C089785:myosin VI; D018995:Myosin Heavy Chains; D009218:Myosins