title: Haemodynamic crisis and reversible multiorgan failure caused by HIV post-exposure prophylaxis after needle-stick injury in a health care worker.
abstract: We report the case of a 59-year-old nurse from our HIV ward who developed a severe haemodynamic crisis with concomitant acute multiorgan failure after initiation of a post-exposure prophylaxis (PEP) with zidovudine/lamivudine (CombivirTM) and lopinavir/ritonavir (KaletraTM) after a needle-stick injury with an HIV-contaminated needle. Although serious and life-threatening adverse effects of post-exposure prophylaxis have been documented in several cases, this is the first report of a severe acute cardiovascular incident following PEP initiation.
authors.affiliation: Department of Gastroenterology, Hepatology and Infectiology, Heinrich Heine University, Dusseldorf, Germany. Feldt@med.uni-duesseldorf.de
authors.forename: T
authors.initials: T
authors.lastname: Feldt
authors.forename: M
authors.initials: M
authors.lastname: Oette
authors.forename: K
authors.initials: K
authors.lastname: Goebels
authors.forename: M
authors.initials: M
authors.lastname: Wenning
authors.forename: A
authors.initials: A
authors.lastname: Kroidl
authors.forename: D
authors.initials: D
authors.lastname: Häussinger
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000150:complications; D016602:Needlestick Injuries / Q000150:complications*; D009726:Nurses; D016273:Occupational Exposure / Q000009:adverse effects*