title: Sleep-promoting properties of quetiapine in healthy subjects.
abstract: The aim of this study was to investigate the effects of quetiapine, an atypical antipsychotic, on polysomnographic sleep structure and subjective sleep quality. This double-blind, placebo-controlled, randomized cross-over study investigated the polysomnographic sleep structure and subjective sleep quality of 14 healthy male subjects given placebo, quetiapine 25 mg or quetiapine 100 mg. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Treatment was administered orally 1 h before bedtime on nights 1 and 2. Quetiapine 25 mg and 100 mg significantly improved sleep induction and continuity under standard and acoustic stress conditions. Increases in total sleep time, sleep efficiency, percentage sleep stage 2 and subjective sleep quality were seen. A significant increase in periodic leg movements during sleep was observed with quetiapine 100 mg. The sleep-improving properties of quetiapine may be important in counteracting different aspects of psychopathology in schizophrenia and other disorders. These sleep-inducing and sleep-modifying properties are probably related to quetiapine's receptor-binding profile, including its antihistaminergic, antidopaminergic and antiadrenergic properties. Other mechanisms might be relevant as well and further investigation is required.
authors.affiliation: Department of Psychiatry and Psychotherapy, Georg-August-University of Göttingen, von-Siebold Strasse 5, D-37075 Göttingen, Germany. scohrs@gwdg.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Cohrs
authors.forename: Andrea
authors.initials: A
authors.lastname: Rodenbeck
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Guan
authors.forename: Kathrin
authors.initials: K
authors.lastname: Pohlmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Jordan
authors.forename: Andreas
authors.initials: A
authors.lastname: Meier
authors.forename: Eckart
authors.initials: E
authors.lastname: Rüther
mesh_terms: D000161:Acoustic Stimulation / Q000009:adverse effects; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology*; D018592:Cross-Over Studies; D003987:Dibenzothiazepines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D017286:Polysomnography / Q000379:methods; D000069348:Quetiapine Fumarate; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000209:etiology; D011795:Surveys and Questionnaires
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate