Autocrine stimulation in colorectal carcinoma (CRC): positive autocrine loops in human colorectal carcinoma and applicable significance of blocking the loops.
Many tumors co-express growth factors and their receptors; thus, the concept of autocrine secretion was proposed to explain the unrestrained growth of the malignant cells. Autocrine stimulation refers to positive autocrine secretion, which functions to stimulate cell growth. Many of the positive autocrine loops have been demonstrated in human colorectal carcinoma (CRC), which are considered to play an important role in the initiation and progression of the cancer. These autocrine loops provide information for prognostic markers and targets for biological therapies of CRC. Interruption of the autocrine loops could potentially inhibit malignant cell growth. The field is encouraging but further research is needed.
Ruan
Wen-Jing
WJ
Department of Pathology, School of Medicine, Zhejiang University, 353 Yan'an Road, Hangzhou 310031, Zhejiang Province, China.
Lai
Mao-De
MD
D019898:Autocrine Communication / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans
D006133:Growth Substances; D005956:Glucose-6-Phosphate Isomerase