title: The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs.
abstract: Diminazene aceturate is a commonly used antibabesial agent. It has been postulated that diminazine may induce a decrease in blood pressure and exacerbate the hypotension presented in dogs with babesiosis. This study was undertaken to assess the effect of diminazine aceturate on the blood pressure of healthy dogs. Six healthy German shepherd dogs between 18 and 24 months of age with a mean weight of 30.4 +/- 2.75 kg were used. Blood pressure was directly measured at the following time intervals: -5, 0, 5, 10, 15, 20, 25, 30, 35, 40, 50, 60, 90 and 120 minutes after treatment with diminazine aceturate (4.2 mg/kg) intramuscularly. No statistical difference (P > 0.05) was found in blood pressure between any of the time intervals. An increase in heart rate was seen 5 minutes after the administration of diminazine aceturate but no change in blood pressure was evident. This study concluded that diminazene aceturate in its current formulation with antipyrine does not alter blood pressure in healthy adult dogs.
authors.affiliation: Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa. kjoubert@op.up.ac.za
authors.forename: K E
authors.initials: KE
authors.lastname: Joubert
authors.forename: F
authors.initials: F
authors.lastname: Kettner
authors.forename: R G
authors.initials: RG
authors.lastname: Lobetti
authors.forename: D M
authors.initials: DM
authors.lastname: Miller
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001404:Babesiosis / Q000188:drug therapy / Q000662:veterinary; D001794:Blood Pressure / Q000187:drug effects*; D004133:Diminazene / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D013997:Time Factors
chemical_list: D000981:Antiprotozoal Agents; C003915:diminazene aceturate; D004133:Diminazene