The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols.
Downregulation of iNOS and NO is a pathway common for flavones and polyphenols, two distinct families of phytoalexins. Our data suggest that inhibition of the NO pathway could be one of the mechanisms involved in the proapoptotic properties of these phytoalexins in leukemia B-cells.
Billard
Christian
C
INSERM E355, Centre Biomédicale des Cordeliers, Paris, France. christian.billard@bhdc.jussieu.fr
Quiney
Claire
C
Tang
Ruoping
R
Kern
Catherine
C
Ajchenbaum-Cymbalista
Florence
F
Dauzonne
Daniel
D
Kolb
Jean-Pierre
JP
D000970:Antineoplastic Agents / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D010636:Phenols / Q000494:pharmacology*; D010880:Piperidines / Q000633:toxicity*; D059808:Polyphenols
D000970:Antineoplastic Agents; D005419:Flavonoids; D010636:Phenols; D010880:Piperidines; D059808:Polyphenols; C077990:alvocidib; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II