title: [Independent role of C reactive protein to predict major events at one-month and at one-year in acute coronary syndrome without ST elevation].
abstract: OBJECTIVE
  We intended to determine whether C-reactive protein (CRP) provides independent prognostic information after a non-ST elevation acute coronary syndrome.
  
  
  METHODS
  We prospectively studied 630 consecutive patients admitted with a diagnosis of non-ST elevation acute coronary syndrome. Cut-off values were: troponin I > 1 ng/ml (n = 354; 56%) and CRP > 11 mg/l (n = 273; 43%).
  
  
  RESULTS
  Within a one-year follow-up period, 56 (9%) cardiac deaths, 85 (13%) myocardial infarctions (MI) and 127 (20%) first major events were detected. Patients with increased CRP showed higher rates of death at one-month (8% vs 1%), death at one-year (15% vs 4%), myocardial infarction at one-month (8% vs 4%), myocardial infarction at one-year (19% vs 9%), major events at one-month (15% vs 5%) and major events at one-year (30% vs 13%). In the multivariate analysis, once adjusted for baseline and electrocardiogram data and for myocardial damage markers, CRP was an independent predictor of death at one-month (odds ratio [OR] 4.6) and death at one-year (OR = 2.7), major events at one-month (OR = 1.8) and major events at one-year (OR = 1.8). Troponin I predicted MI at one-month (OR = 2.5) and MI at one-year (OR = 2.2).
  
  
  CONCLUSIONS
  CRP provided independent information to predict major events in non-ST elevation acute coronary syndromes. Troponin I was a more powerful predictor of MI than PCR. The analysis of CRP and myocardial damage markers in the short-term and long-term risk stratification seems worthy.
authors.affiliation: Servicio de Cardiología, Hospital Clínico y Universitario, Universidad de Valencia, Spain. vicentbodi@hotmail.com
authors.forename: Vicent
authors.initials: V
authors.lastname: Bodí
authors.forename: Juan
authors.initials: J
authors.lastname: Sanchis
authors.forename: Angel
authors.initials: A
authors.lastname: Llàcer
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Fácila
authors.forename: Julio
authors.initials: J
authors.lastname: Núñez
authors.forename: Mauricio
authors.initials: M
authors.lastname: Pellicer
authors.forename: Vicente
authors.initials: V
authors.lastname: Bertomeu
authors.forename: Vicente
authors.initials: V
authors.lastname: Ruiz
authors.forename: Diego
authors.initials: D
authors.lastname: García
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Chorro
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis* / Q000401:mortality; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D013577:Syndrome; D013997:Time Factors; D019210:Troponin I / Q000032:analysis
chemical_list: D015415:Biomarkers; D019210:Troponin I; D002097:C-Reactive Protein