title: Rapidly progressive pulmonary fibrosis in a patient treated with danazol for idiopathic thrombocytopenic purpura.
abstract: The case of a patient that developed pulmonary fibrosis two months after initiation of danazol for treatment of idiopathic thrombocytopenic purpura is described. Bilateral pneumothoraxes and pneumomediastinum complicated the rapidly fatal pulmonary fibrosis. An association between danazol therapy and the development of pulmonary fibrosis is suspected. There is only one other case report with this connection in the literature.
authors.affiliation: Department of Respirology, Toronto General Hospital, Toronto, Onrtario. Smita.pakhale@utoronto.ca
authors.forename: Smita
authors.initials: S
authors.lastname: Pakhale
authors.forename: Yuri
authors.initials: Y
authors.lastname: Moltyaner
authors.forename: Dean
authors.initials: D
authors.lastname: Chamberlain
authors.forename: Neil
authors.initials: N
authors.lastname: Lazar
mesh_terms: D000368:Aged; D003613:Danazol / Q000009:adverse effects*; D004965:Estrogen Antagonists / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D011030:Pneumothorax / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy*; D011859:Radiography
chemical_list: D004965:Estrogen Antagonists; D003613:Danazol