title: [Synthesis and antiviral activity of amides and conjugates of betulonic acid with amino acids].
abstract: Betulonic acid amides with aliphatic and heterocyclic amines and with L-amino acids were synthesized by the acid chloride method. Betulonic acid amide and L-methionine derivatives of betulonic acid and its 3-oxime effectively inhibit the influenza A virus. Betulonic acid octadecylamide is active against the herpes simplex type 1 virus. The conjugate of betulonic acid 3-oxime with L-methionine is also active toward HIV-1. The tested compounds mainly show no activity toward the ECHO6 virus, which is devoid of a coat. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
authors.affiliation: Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054 Russia.
authors.forename: O B
authors.initials: OB
authors.lastname: Flekhter
authors.forename: E I
authors.initials: EI
authors.lastname: Boreko
authors.forename: E V
authors.initials: EV
authors.lastname: Tret'iakova
authors.forename: N I
authors.initials: NI
authors.lastname: Pavlova
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: S N
authors.initials: SN
authors.lastname: Nikolaeva
authors.forename: O V
authors.initials: OV
authors.lastname: Savinova
authors.forename: V F
authors.initials: VF
authors.lastname: Eremin
authors.forename: F Z
authors.initials: FZ
authors.lastname: Galin
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D002642:Chick Embryo; D015497:HIV-1 / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D000094062:Betulinic Acid
chemical_list: D000577:Amides; D000596:Amino Acids; D000998:Antiviral Agents; D009828:Oleanolic Acid; C118308:betulonic acid; D000094062:Betulinic Acid