Inhibition of apoptosis by amphiregulin via an insulin-like growth factor-1 receptor-dependent pathway in non-small cell lung cancer cell lines.
The reciprocal activation of amphiregulin (AR) and insulin-like growth factor-1 (IGF1) pathways has been shown to induce inhibition of serum deprivation apoptosis in non-small cell lung cancer (NSCLC) cell lines H358 and H322. We demonstrated that AR activated the IGF1 receptor (IGF1-R), which in turn induced the secretion of AR and IGF1. Transactivation of the IGF1-R by AR is independent of its binding to EGFR. Thus, AR can inhibit apoptosis in NSCLC cells through an IGF1-R-dependent pathway.
Hurbin
Amandine
A
Groupe de Recherche sur le Cancer du Poumon, INSERM-U578, Institut Albert Bonniot, La Tronche 38706 Cedex, France. amandine.hurbin@ujf-grenoble.fr
Dubrez
Laurence
L
Coll
Jean-Luc
JL
Favrot
Marie C
MC
D066258:Amphiregulin; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D002289:Carcinoma, Non-Small-Cell Lung; D045744:Cell Line, Tumor; D016895:Culture Media, Serum-Free; D066255:EGF Family of Proteins; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology*; D008175:Lung Neoplasms; D017526:Receptor, IGF Type 1 / Q000187:drug effects / Q000502:physiology*; D020032:Tyrphostins / Q000494:pharmacology
C587848:AREG protein, human; D066258:Amphiregulin; D016895:Culture Media, Serum-Free; D066255:EGF Family of Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; D020032:Tyrphostins; C447031:tyrphostin AG 1024; D017526:Receptor, IGF Type 1