Risk factors for central serous chorioretinopathy: a case-control study.
OBJECTIVE
To identify systemic factors associated with the development of central serous chorioretinopathy (CSCR).


METHODS
Retrospective, case-control study.


METHODS
312 cases and 312 controls.


RESULTS
By use of a multivariate analysis, the previously described risk factors, systemic steroid use (odds ratio [OR], 37.1; 95% confidence interval [CI], 6.2-221.8), and pregnancy (OR, 7.1; 95% CI, 1.0-50.7), were strongly associated with CSCR. Additional risk factors identified by this study include antibiotic use (OR, 6.2; 95% CI, 1.0-37.9), alcohol use (OR, 4.9; 95% CI, 1.5-16.3), untreated hypertension (OR, 3.3; 95% CI, 1.3-8.5), and allergic respiratory disease (OR, 2.5; 95% CI, 1.2-5.1).


CONCLUSIONS
A wide variety of systemic factors are associated with CSCR. Prospective studies are warranted to evaluate the nature and significance of these associations further.
Haimovici
Robert
R
Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts 02114, USA.
Koh
Sean
S
Gagnon
David R
DR
Lehrfeld
Todd
T
Wellik
Sarah
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015862:Choroid Diseases / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors