Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood.
Previous studies involving identical twins with concordant leukemia and retrospective scrutiny of archived neonatal blood spots have shown that common chromosome translocations of pediatric leukemia frequently arise before birth. The IGH/TCR clonotypic sequences used as surrogate molecular markers suggest this is also likely to be true for hyperdiploid acute lymphoblastic leukemia (ALL). Yet evidence that hyperdiploidy itself is an early or initiating event occurring prenatally has been limited. Now, however, we can provide direct evidence of this from our identification of CD34+/CD19+ B-lineage progenitor cells with triploid chromosomes in the stored cord blood of an individual who subsequently developed hyperdiploid ALL.
Maia
Ana Teresa
AT
LRF Centre, Institute of Cancer Research, London, UK.
Tussiwand
Roxane
R
Cazzaniga
Giovanni
G
Rebulla
Paolo
P
Colman
Susan
S
Biondi
Andrea
A
Greaves
Mel
M
D018941:Antigens, CD19 / Q000096:biosynthesis; D018952:Antigens, CD34 / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000737:chemistry / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D006684:HLA-DR Antigens / Q000096:biosynthesis; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D011123:Polyploidy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics*; D011289:Preleukemia / Q000175:diagnosis* / Q000235:genetics*; D013234:Stem Cells / Q000737:chemistry / Q000378:metabolism / Q000473:pathology
D018941:Antigens, CD19; D018952:Antigens, CD34; D006684:HLA-DR Antigens