title: [Prognostic and predictive factors of patients with cancer of unknown origin treated with a paclitaxel-based chemotherapy].
abstract: OBJECTIVE
  Taxane-based combinations appear to be promising for the treatment of carcinoma of unknown primary site (CUPS).
  
  
  METHODS
  Patients with CUPS not corresponding to any favourable subset were treated with paclitaxel, carboplatin and etoposide. Interaction between various factors with survival was analyzed. A regression model was applied to identify factors with independent prognostic significance.
  
  
  RESULTS
  48 patients were included and 15 responses were observed with a median overall survival of 7.4 months. In the multivariate analysis, performance status and hypoalbuminemia were negatively associated with overall survival.
  
  
  CONCLUSIONS
  Some patients can achieve complete response and prolonged survival. This treatment cannot be recommended for patients with a regular performance status. A better knowledge of prognostic factors and a definition of more subgroups with favourable outcome are needed.
authors.affiliation: Servicio de Oncología Médica, Hospital de Cruces, Barakaldo, Bizkaia, España.
authors.forename: Alberto
authors.initials: A
authors.lastname: Muñoz
authors.forename: Natalia
authors.initials: N
authors.lastname: Fuente
authors.forename: Ramón
authors.initials: R
authors.lastname: Barceló
authors.forename: Itziar
authors.initials: I
authors.lastname: Rubio
authors.forename: Josefa
authors.initials: J
authors.lastname: Ferreiro
authors.forename: Guillermo
authors.initials: G
authors.lastname: López Vivanco
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009382:Neoplasms, Unknown Primary / Q000188:drug therapy* / Q000401:mortality; D017239:Paclitaxel / Q000008:administration & dosage; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D005047:Etoposide; D016190:Carboplatin; D017239:Paclitaxel