Fetal inherited thrombophilias influence the severity of preeclampsia, IUGR and placental abruption.
OBJECTIVE
To determine whether common inherited thrombophilias in the fetus influence the severity of severe preeclampsia, IUGR and placental abruption.


METHODS
A case-control study among patients with complicated pregnancies. Cases were defined as fetuses with thrombophilia.


METHODS
A university hospital with 3700 deliveries per year.


METHODS
Seventy cases with severe preeclampsia, IUGR or placental abruption.


METHODS
Mothers and neonates were tested for mutation of factor V Leiden, prothrombin gene and methylenetetrahydrofolate reductase.


METHODS
Gestational age at delivery, birth weight and early neonatal complications.


RESULTS
Gestational age at delivery and birth weight were significantly lower in fetuses with factor V Leiden or prothrombin gene mutation compared to control fetuses.


CONCLUSIONS
Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption. These thrombophilic changes may cause an earlier appearance or lead to a late pregnancy complication of a greater severity.
Anteby
Eyal Y
EY
Department of Obstetrics and Gynecology, Hadassah University Hospital, P.O. Box 24035, Mt. Scopus, Jerusalem, Israel. anteby@cc.huji.ac.il
Musalam
Banan
B
Milwidsky
Ariel
A
Blumenfeld
Anat
A
Gilis
Shmuel
S
Valsky
Dan
D
Hamani
Yaron
Y
D000037:Abruptio Placentae / Q000235:genetics; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D005315:Fetal Diseases / Q000235:genetics*; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D011225:Pre-Eclampsia / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications; D012720:Severity of Illness Index; D019851:Thrombophilia / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V