title: SARS--beginning to understand a new virus.
abstract: The 114-day epidemic of the severe acute respiratory syndrome (SARS) swept 29 countries, affected a reported 8,098 people, left 774 patients dead and almost paralyzed the Asian economy. Aggressive quarantine measures, possibly aided by rising summer temperatures, successfully terminated the first eruption of SARS and provided at least a temporal break, which allows us to consolidate what we have learned so far and plan for the future. Here, we review the genomics of the SARS coronavirus (SARS-CoV), its phylogeny, antigenic structure, immune response and potential therapeutic interventions should the SARS epidemic flare up again.
authors.affiliation: IRIS, Chiron S.r.l., Via Fiorentina 1, 53100 Siena, Italy.
authors.forename: Konrad
authors.initials: K
authors.lastname: Stadler
authors.forename: Vega
authors.initials: V
authors.lastname: Masignani
authors.forename: Markus
authors.initials: M
authors.lastname: Eickmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Becker
authors.forename: Sergio
authors.initials: S
authors.lastname: Abrignani
authors.forename: Hans-Dieter
authors.initials: HD
authors.lastname: Klenk
authors.forename: Rino
authors.initials: R
authors.lastname: Rappuoli
mesh_terms: D000818:Animals; D016679:Genome, Viral; D023281:Genomics; D006801:Humans; D010802:Phylogeny; D045473:Severe acute respiratory syndrome-related coronavirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000628:therapy / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D014764:Viral Proteins