title: [Effect of dehydration on nitric oxide, corticotropic and vasopressinergic axis in rat].
abstract: Effect of dehydration on nitric oxide, corticotropic and vasopressinergic axis in rat. The purpose of our work is to study, in the male 'Wistar' rat, the effects of a chronic dehydration, by deprivation of water for three days out of four, during four repeated cycles, on the evolution of certain blood variables, on the activities of both corticotropic and vasopressinergic axis and on the synthesis of nitric oxide. The chronic dehydration causes a considerable reduction of the body weight, an activation of the vasopressinergic axis and an increase in the circulating rates of the nitrates/nitrites, which represent the final metabolites of the reaction of oxidation of nitric oxide. The pituitary-adrenal axis is not statistically affected by the chronic dehydration. This seems to be in favour of a possible adaptation of corticotropic axis to chronic water deprivation. The activation of synthesis of nitric oxide shows its implication in the regulation of the water balance and its buffer effect on vasoconstriction and hypertension induced by water stress.
authors.affiliation: Laboratoire de physiologie animale, département de biologie, faculté des sciences de Tunis El-Manar, campus universitaire, 1060 Tunis, Tunisie. najoua.gharbi@planet.tn
authors.forename: Najoua
authors.initials: N
authors.lastname: Gharbi
authors.forename: Bessem
authors.initials: B
authors.lastname: Mornagui
authors.forename: Saloua
authors.initials: S
authors.lastname: El-Fazaâ
authors.forename: Abdelaziz
authors.initials: A
authors.lastname: Kamoun
authors.forename: Claude
authors.initials: C
authors.lastname: Gharib
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D002908:Chronic Disease; D003681:Dehydration / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001127:Arginine Vasopressin; D009569:Nitric Oxide; D000324:Adrenocorticotropic Hormone