Evaluation of the efficacy of polydeoxyribonucleotides in the healing process of autologous skin graft donor sites: a pilot study.
OBJECTIVE
The article presents the results of a pilot study performed to evaluate the efficacy of polydeoxyribonucleotides (PDRNs) in shortening the healing times of autologous skin graft donor sites. RESEARCH DESIGN, METHODS: Two groups of patients were studied, the PDRN group (n = 20) and a control group (n = 20). In the control group dressings were performed with non-adherent gauzes and bulky gauzes with cloramine solution, whereas in the PDRN group a PDRN ointment was spread under the same medication as the controls.


RESULTS
In the PDRN group, dressing procedures were not painful (whereas in the controls they often were), re-epithelialisation occurred earlier (12.5 vs 24.45 days) and there were no infections (9 in the controls).


CONCLUSIONS
Results are encouraging for the use of PDRNs in shortening the healing times of autologous skin graft donor sites, although further studies are necessary to obtain clinically relevant results.
Valdatta
Luigi
L
Plastic Surgery Unit, University of Insubria, Ospedale di Circolo-Fondazione Macchi, Varese, Italy. chirplas@liberto.it
Thione
Alessandro
A
Mortarino
Christian
C
Buoro
Mara
M
Tuinder
Stefania
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003879:Dermatologic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011089:Polydeoxyribonucleotides / Q000494:pharmacology* / Q000627:therapeutic use; D016038:Skin Transplantation / Q000379:methods*; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
D003879:Dermatologic Agents; D011089:Polydeoxyribonucleotides