Catalog of 300 SNPs in 23 genes encoding G-protein coupled receptors.
We previously published a series of detailed maps of single nucleotide polymorphisms (SNPs) in the genomic regions of 209 gene loci encoding drug metabolizing enzymes, transporters, receptors, and other potential drug targets. In addition to the maps reported earlier, we provide here high-resolution SNP maps of 23 genes encoding G-protein coupled receptors in the Japanese population. A total of 300 SNPs were identified through screening of these loci; 83 in four adenosine receptor family genes, 45 in three adrenergic receptor family genes, 22 in three EDG receptor family genes, 29 in three melanocortin receptor family genes, 22 in two somatostatin receptor family genes, 21 in five anonymous G protein-coupled receptor family genes, and 78 in the others (AVPR1B, OXTR, and TNFRSF1A). We also discovered a total of 33 genetic variations of other types. Of the 300 SNPs, 132 (44%) appeared to be novel on the basis of comparisons with the dbSNP database of the National Center for Biotechnology Information (US) or with previous publications. The maps constructed in this study will serve as an additional resource for studies of complex genetic diseases and drug-response phenotypes to be mapped by linkage-disequilibrium association analyses.
Iida
Aritoshi
A
Laboratory for Pharmacogenetics, Research Groups of Personalized Medicine, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, 1-7-22 Suenhiro-cho, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan. iidaari@src.riken.go.jp.
Saito
Susumu
S
Laboratory for SNP Analysis, Research Groups of Personalized Medicine, RIKEN SNP Research Center, c/o Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Sekine
Akihiro
A
Laboratory for Genotyping, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, Kanagawa, Japan.
Kataoka
Yukie
Y
Laboratory for Genotyping, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, Kanagawa, Japan.
Tabei
Wataru
W
Laboratory for Genotyping, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, Kanagawa, Japan.
Nakamura
Yusuke
Y
Laboratory for Pharmacogenetics, Research Groups of Personalized Medicine, RIKEN SNP Research Center, c/o RIKEN Yokohama Institute, 1-7-22 Suenhiro-cho, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan.|Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
D002377:Catalogs as Topic; D004247:DNA / Q000097:blood / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*
D017931:DNA Primers; D043562:Receptors, G-Protein-Coupled; D004247:DNA