title: Translocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma).
abstract: Collagenous fibroma (desmoplastic fibroblastoma) is a rare, benign tumor composed of spindle and stellate-shaped fibroblasts and myofibroblasts in a densely collagenous background. A t(2;11)(q31;q12) has been reported in one case of collagenous fibroma and a rearrangement of the 11q12 breakpoint in a second case. In the present study, we detected a t(2;11) identical to that previously described in a collagenous fibroma arising in the supraclavicular fossa of a 55-year-old man. This finding confirms the nonrandom association of t(2;11)(q31;q12) with collagenous fibroma.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-3135, USA.
authors.forename: Kerry
authors.initials: K
authors.lastname: Bernal
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: James R
authors.initials: JR
authors.lastname: Neff
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Nielsen
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D018220:Fibroma, Desmoplastic / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic