Amphidinolides, bioactive macrolides from symbiotic marine dinoflagellates.
This review covers the structures, synthesis, biosynthesis, and bioactivity of a series of cytotoxic macrolides, named amphidinolides, isolated from symbiotic marine dinoflagellates of the genus Amphidinium which were separated from inside cells of marine flatworms. The structures of long-chain polyketides such as colopsinols isolated from Amphidinium sp. are also described.
Kobayashi
Jun'ichi
J
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Tsuda
Masashi
M
D000818:Animals; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry*; D004141:Dinoflagellida / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D008386:Marine Biology; D015394:Molecular Structure
D001685:Biological Factors; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007783:Lactones; D018942:Macrolides