title: [Protective effect of curcumin on experimental liver injury in mice].
abstract: OBJECTIVE
  To Study the protective effect of curcumin on three models of experimental liver injury in mice.
  
  
  METHODS
  The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.
  
  
  RESULTS
  Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.
  
  
  CONCLUSIONS
  Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.
authors.affiliation: Department of Pharmacology, First Military Medical University, Guangzhou 510515, Guandong, China.
authors.forename: Yong-gang
authors.initials: YG
authors.lastname: Liu
authors.forename: Hou-chang
authors.initials: HC
authors.lastname: Chen
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Jiang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury; D003474:Curcumin / Q000494:pharmacology*; D005688:Galactosamine; D008070:Lipopolysaccharides; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000097:blood* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D009569:Nitric Oxide / Q000097:blood; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: C042138:BCG lipopolysaccharide; D008070:Lipopolysaccharides; D020011:Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003474:Curcumin