title: [Effect of SS8, the active part of Spatholobus suberectus Dunn, on proliferation of hematopoietic progenitor cells in mice with bone marrow depression].
abstract: OBJECTIVE
  To investigate the effect of SS8, a monomer extracted from Spatholobus suberectus Dunn used for invigorating the circulation of blood, on proliferation of hematopoietic progenitor cells in mice with bone marrow depression.
  
  
  METHODS
  The method of semi-solid culture with methylcellulose of CFU-GM, CFU-E, BFU-E, CFU-Meg was adopted in bone marrow depressed mice which were treated with SS8 for a long time.
  
  
  RESULTS
  The experimental data demonstrated that the numbers of CFU-GM, CFU-E, BFU-E, CFU-Meg in bone marrow depressed mice were raised distinctly under the control of SS8 as compared with those of contrast group. The effect of SS8 became stronger as time went on and the dosage rose.
  
  
  CONCLUSIONS
  SS8 can distinctly stimulate the proliferation of hematopoietec progenitor cells in mice with bone marrow depression in a time-and-dosagedependent manner.
authors.affiliation: Research Institute for Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China.
authors.forename: Dong-xiao
authors.initials: DX
authors.lastname: Wang
authors.forename: Meng-li
authors.initials: ML
authors.lastname: Chen
authors.forename: Jian-fen
authors.initials: JF
authors.lastname: Yin
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000528:radiation effects*; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000528:radiation effects; D007887:Fabaceae / Q000737:chemistry; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D014916:Whole-Body Irradiation
chemical_list: D004365:Drugs, Chinese Herbal