title: [Clinical study of hyaluronic acid in the treatment of chronic periodontitis].
abstract: OBJECTIVE
  Clinical effects in local application of hyaluronic acid (HA) adjunctive to scaling and root planing (SRP) were evaluated.
  
  
  METHODS
  In this cross over design study 20 patients with chronic periodontitis were included. Plaque index, sulcus-fluid-flow-rate (SFFR), sulcus bleeding index, probing pocket depth and attachment level were monitored. All patients were treated with full mouth SRP, in addition a HA gel was administered subgingivally in the test site every week for 6 weeks.
  
  
  RESULTS
  A statistically significant improvement of all clinical test parameters was observed in both groups (P < 0.05). Clinically, no significant difference between test and control group could be found. However, the SFFR decreased significantly faster in the test group.
  
  
  CONCLUSIONS
  No post-inflammatory tissue regeneration could be achieved by the adjunctive use of HA gel to SRP in the patients with chronic periodontitis. Due to SFFR a control of local inflammation can be achieved quickly.
authors.affiliation: Dept. of Periodontology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Frentzen
authors.forename: P M
authors.initials: PM
authors.lastname: Jerve-  Storm
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D012534:Dental Scaling; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket; D010518:Periodontitis / Q000188:drug therapy*; D016745:Root Planing
chemical_list: D006820:Hyaluronic Acid