title: An efficient synthesis of 3-substituted 3H-pyrimidin-4-ones.
abstract: [reaction: see text] A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available beta-keto esters, with trimethylaluminum and various primary amines.
authors.affiliation: Department of Medicinal Chemistry, MMPD CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA. jae.u.jeong@gsk.com
authors.forename: Jae Uk
authors.initials: JU
authors.lastname: Jeong
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Chen
authors.forename: Attiq
authors.initials: A
authors.lastname: Rahman
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Yamashita
authors.forename: Juan I
authors.initials: JI
authors.lastname: Luengo