Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development.
New blood vessel formation is important in many physiological process, including development, wound repair, and tumor growth. In aged animals, angiogenesis is reduced resulting in poor wound healing. We have identified a novel small molecule, thymosin beta(4), that promotes angiogenesis and wound repair in both normal and aged rodents. It also promotes hair growth in normal and aged rodents. It acts by increasing angiogenesis and cell migration and is currently in clinical trials for wound repair.
Philp
D
D
Cell Biology Section, CDBRB, National Institute of Dental and Craniofacial Research (NIDCR), NIH 30/433, Bethesda, MD 20892, USA.
Goldstein
A L
AL
Kleinman
H K
HK
D000375:Aging / Q000502:physiology; D000818:Animals; D004817:Epidermis / Q000293:injuries* / Q000502:physiology; D018859:Hair Follicle / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D013947:Thymosin / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*; D000099201:Thymosin beta(4)
D013947:Thymosin; D000099201:Thymosin beta(4)