Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity?
Large uncontrollable detrusor contractions, decreased compliance that increases luminal pressures during filling, and detrusor underactivity are all examples of abnormal bladder function. Studies of the nervous control of lower urinary tract function and measurement of the cellular properties of the component tissues of the bladder wall have been performed to deepen our knowledge of these problems. The resultant data have suggested that lower urinary tract smooth muscle should not be regarded solely as a collection of independent cellular contractile units that are each activated by separate neural inputs, but also as a syncytium of cells. Although this syncytial arrangement may not be as well developed as in other tissues, it should impose a new layer of activity that will affect overall bladder function. Recent studies have addressed this issue through investigation of spontaneous contractile activity, the cellular basis of syncytial function, and their normal and abnormal functional consequences. The results suggest that individual detrusor cells possess membrane properties that may lead to spontaneous activity fluctuations, which can affect adjacent cells and, thus, produce multicellular aberrant responses. It remains unclear whether these responses manifest themselves as dysfunctional activity in the whole bladder defects because the extent of local multicellular abnormalities is not known at present. The data do imply that myogenic defects can contribute to abnormal bladder function and, thus, suggest several new targeted drug models that should be explored.
Fry
Christopher H
CH
Institute of Urology & Nephrology, London, United Kingdom. c.fry@ucl.ac.uk
Sui
Gui-Ping
GP
Severs
Nicholas J
NJ
Wu
Changhao
C
D000818:Animals; D015220:Calcium Channels; D017629:Gap Junctions; D006706:Homeostasis; D006801:Humans; D008564:Membrane Potentials; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology*; D032389:Myocytes, Smooth Muscle; D001743:Urinary Bladder / Q000166:cytology / Q000502:physiology*; D001745:Urinary Bladder Diseases / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology*
D015220:Calcium Channels