Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).
Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). Immunized monkeys developed anti-Abeta titers exceeding 1:1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta.
Gandy
Sam
S
Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA. samgandy@earthlink.net
DeMattos
Ron B
RB
Lemere
Cynthia A
CA
Heppner
Frank L
FL
Leverone
Jodi
J
Aguzzi
Adriano
A
Ershler
William B
WB
Dai
Jinlu
J
Fraser
Paul
P
St George Hyslop
Peter
P
Holtzman
David M
DM
Walker
Lary C
LC
Keller
Evan T
ET
D000375:Aging / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology* / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000097:blood; D005260:Female; D008253:Macaca mulatta; D010446:Peptide Fragments / Q000276:immunology*; D014612:Vaccines / Q000276:immunology / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D000906:Antibodies; D010446:Peptide Fragments; D014612:Vaccines; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)