[Morphological types of the glandular epithelium nuclei from benign and malignant mammary gland diseases].
The morphometric parameters of the nuclear-nucleolar apparatus of benign and malignant mammary cells were investigated by computer-aided morphometry of cytological specimen stained by a 50% silver nitrate solution. On the basis of a static analysis of measurement results a computer soft was created to classify the nuclei. The soft, with respect to an analysis of the discriminative functions and to a variety of formally logical limitations, subdivides the nuclei into 6 morphotypes with variations "a" and "b", which correspond to certain clinical and morphological variants of breast diseases. From the practical viewpoint, the subdivision of nuclei into the 3rd and 4th morphotypes is most interesting because it can provide the clinical cytology expert with extra information for the differential diagnostics of proliferative and malignant transformations in the mammary glands as well as for the definition of dysplasia stages and for the determination of tumor-cell malignancy degree.
Tsygankov
V I
VI
Mel'nikova
N P
NP
Mogileva
G L
GL
Vyborov
S G
SG
D001941:Breast Diseases / Q000175:diagnosis / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000648:ultrastructure; D016002:Discriminant Analysis; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D042361:Mammary Glands, Human / Q000473:pathology / Q000648:ultrastructure*