[Experimental study of mandibular reconstruction with Sr-HAP].
OBJECTIVE
Different ration of Sr-HAP was implanted in animals to study the bioreactions in order to prepare for the clinical applications in future.


METHODS
24 rabbits were divided into 3 groups for study.Bone defect of 6 x 12 x 4 mm was made at the mandibular angle of rabbits and Sr-HAP of different proportion (10%,5%,0%) was applied to repair the defect. One group of animals were killed at 1 month, 3 months, 6 months to evaluate the biologic capacity with anatomy, tetracycline fluorescent marker and ration histology.


RESULTS
Sr-HAP almost hadn't been rejected by hosts, and early after operation the new bone in the Sr-HAP was found with great quantities as the degradation of Sr-HAP much more than that in the pure HA, and the difference of bone quantity can be shown in statistics. New bone in 5% Sr-HAP looked more mature than those in 10% Sr-HAP with no statistic difference in quantity. Strong and bright fluorescent rings can be seen around Sr-HAP from the 3 months to 6 months.


CONCLUSIONS
(1) Sr-HAP has a better biocompatibility, biodegradation than pure HA and an excellent osteoinductivity. (2) The ration of strontium isn't the key influencing the new bone quantity,total new bone quantity maybe associated with the degree of biodegradation. (3) The existence of Sr-HAP improves the total new bone quantity and prolongs the period of new bone increasing.
Liao
D P
DP
Department of Oral & Maxillofacial Surgery, Gangquan Hospital, Shanghai Tiedao University. Shanghai 200065, China.
Zhou
Z Y
ZY
Gu
Y F
YF
Chen
D M
DM