title: [Advances in studies on chemical constituents of Senecio].
abstract: The large cosmopolitan genus Senecio, a perennial medicinal herb of the family compositae, has been utilized as a anthmicrobial agent. A variety of pyrrolizidine alkaloids and furanoeremophilanes are widespread in the genus Senecio, which are responsible for the hepatotoxic and carchnogenic effects. Some of them have been screened for anti-tumour activity, but their liver toxicity renders their use in chemotherapy. This article reviews the recent advances in chemical constituents, identification methods and pharmacological activities of it.
authors.affiliation: Natural Medicine Research Lab., Shenyang Pharmaceutical University, Shengyang 110016, Liaoning, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Wu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012674:Senecio / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D011763:Pyrrolizidine Alkaloids; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C412858:otonecine; C015872:eudesmane