Cyclodextrin trimers as receptors for arranging ester and catalyst at optimized location to achieve enhancement of hydrolytic activity.
Two novel trimer receptor molecules (AC and AD trimers) consisting of two alpha-cyclodextrins (alpha-CDs) and one beta-cyclodextrin (beta-CD) have been designed and synthesized in order to make an optimum arrangement between a substrate and a catalyst. In the reaction systems that use trimer receptors as host molecules, the substrate and the catalyst are thought to be accommodated by two alpha-CDs and one beta-CD, respectively. The rate for the hydrolytic reaction of a long-shaped ester was largely increased, when the trimer receptors were used as receptor molecules or molecular flasks, which provided optimum location between the substrate and the catalyst.
Nakajima
Hiroki
H
Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Sakabe
Yuzuru
Y
Ikeda
Hiroshi
H
Ueno
Akihiko
A
D002384:Catalysis; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*; D004952:Esters; D006868:Hydrolysis
D003505:Cyclodextrins; D004952:Esters