The effects of quercetin vs cisplatin on proliferation and the apoptotic process in A549 and SW1271 cell lines in in vitro conditions.
Experience over several years has indicated that chemotherapy, even if widely used, does not always remain effective in the therapy of lung tumours and, in addition, is linked to serious side effects. In parallel, some plant polyphenols are known to exert a proapoptotic action on tumour cells while, in contrast, representing anti-cancerogenic anti-oxidants in living organisms. Our studies were aimed at comparing the effects of a polyphenol, quercetin, and cisplatin on cells of various types of lung cancer in in vitro conditions. In these studies we also attempted to define the relationship between the dose and the duration of the activity of the compounds. Cisplatin alone was found to induce only a small reaction in the cells, while in combination with quercetin its anti-proliferative and pro-apoptotic effects were amplified, depending upon the type of tumour, the dose and the duration of the drug's action.
Borska
Sylwia
S
Department of Histology and Embryology, University School of Medicine, Wrocław, Poland. borska@hist.am.wroc.pl
Gebarowska
Elzbieta
E
Wysocka
Teresa
T
Drag-Zalesińska
Małgorzata
M
Zabel
Maciej
M
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011794:Quercetin / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004338:Drug Combinations; D011794:Quercetin; D002945:Cisplatin