Stroke-like pattern in DTI and MRS of childhood mitochondrial leukoencephalopathy.
In a 13-month-old boy with recurrent motor deterioration provoked by fever MRI and proton MRS detected a leukoencephalopathy with reduced cerebral metabolites and elevated lactate. At follow-up 6 and 16 months later these abnormalities improved gradually. Serial diffusion tensor imaging revealed a stroke-like pattern with an initial strong reduction of the apparent diffusion coefficient followed by elevated values 6 months later. The relative diffusion anisotropy remained reduced. Muscle biopsy confirmed a mitochondrial encephalomyopathy.
Brockmann
K
K
Department of Paediatrics and Neuropaediatrics, Georg August University, Göttingen, Germany. kbrock@med.uni-goettingen.de
Finsterbusch
J
J
Schara
U
U
Wilichowski
E
E
Frahm
J
J
Hanefeld
F
F
D016880:Anisotropy; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D017237:Mitochondrial Encephalomyopathies / Q000473:pathology*; D012075:Remission, Spontaneous