Pseudo-likelihood estimation for a marginal multivariate survival model.
In this paper, we propose a multivariate Plackett-Dale model for survival outcomes. A pseudo-likelihood method for the estimation of the parameters is proposed and these ideas are applied to two case studies. The modelling approach is similar in spirit but different from Parner's approach. The first study is in AIDS, where the overall survival time and different opportunistic infections in HIV-infected patients are studied. The second study is on adoption data where the association of the survival times within families is modelled, illustrating the use of the proposed methodology for the context of population genetics.
Tibaldi
Fabián
F
Center for Statistics, Limburgs Universitair Centrum, Transnationale Universiteit Limburg, Diepenbeek Universitaire Campus, B3590 Diepenbeek, Belgium. fabian.tibaldi@luc.ac.be
Molenberghs
Geert
G
Burzykowski
Tomasz
T
Geys
Helena
H
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000300:Adoption; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D016049:Didanosine / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D015233:Models, Statistical; D015999:Multivariate Analysis; D016019:Survival Analysis; D015215:Zidovudine / Q000494:pharmacology / Q000627:therapeutic use
D000998:Antiviral Agents; D015215:Zidovudine; D016049:Didanosine