title: Dactinomycin-induced veno-occlusive disease in rats. The hepatoprotective action of amifostine. Evaluation in a light and electron microscope.
abstract: The purpose of the study was to draw upan experimental model of hepatic veno-occlusive disease (VOD) induced by dactinomycin (ACT) and to investigate the possible hepatoprotective effects of Ethyol (amifostine). Pathological changes corresponding to a VOD picture of varying intensification were found in the liver samples obtained from all the rats receiving ACT. Amifostine appears to act protectively to liver changes caused by dactinomycin.
authors.affiliation: Department of Histology and Embryology, Medical University, Białystok, Poland. histolog@amb.edu.pl
authors.forename: Halina
authors.initials: H
authors.lastname: Borowska
authors.forename: Ewa
authors.initials: E
authors.lastname: Arciszewska
authors.forename: Piotr
authors.initials: P
authors.lastname: Czauderna
authors.forename: Bogusław
authors.initials: B
authors.lastname: Sawicki
mesh_terms: D004999:Amifostine / Q000494:pharmacology; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000633:toxicity*; D003609:Dactinomycin / Q000008:administration & dosage / Q000633:toxicity*; D004336:Drug Antagonism; D006003:Glycogen / Q000378:metabolism; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D022781:Hepatocytes / Q000187:drug effects / Q000648:ultrastructure; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D010503:Periodic Acid-Schiff Reaction; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000903:Antibiotics, Antineoplastic; D011837:Radiation-Protective Agents; D003609:Dactinomycin; D006003:Glycogen; D004999:Amifostine