title: Social function in schizophrenia and schizoaffective disorder: associations with personality, symptoms and neurocognition.
abstract: BACKGROUND
  Research has indicated that stable individual differences in personality exist among persons with schizophrenia spectrum disorders predating illness onset that are linked to symptoms and self appraised quality of life. Less is known about how closely individual differences in personality are uniquely related to levels of social relationships, a domain of dysfunction in schizophrenia more often linked in the literature with symptoms and neurocognitive deficits. This study tested the hypothesis that trait levels of personality as defined using the five-factor model of personality would be linked to social function in schizophrenia.
  
  
  METHODS
  A self-report measure of the five factor model of personality was gathered along with ratings of social function, symptoms and assessments of neurocognition for 65 participants with schizophrenia or schizoaffective disorder.
  
  
  RESULTS
  Univariate correlations and stepwise multiple regression indicated that frequency of social interaction was predicted by higher levels of the trait of Agreeableness, fewer negative symptoms, better verbal memory and at the trend level, lesser Neuroticism (R2 =.42, p <.0001). In contrast, capacity for intimacy was predicted by fewer negative symptoms, higher levels of Agreeableness, Openness, and Conscientiousness and at the trend level, fewer positive symptoms (R2 =.67, p <.0001).
  
  
  CONCLUSIONS
  Taken together, the findings of this study suggest that person-centered variables such as personality, may account for some of the broad differences seen in outcome in schizophrenia spectrum disorders, including social outcomes. One interpretation of the results of this study is that differences in personality combine with symptoms and neurocognitive deficits to affect how persons with schizophrenia are able to form and sustain social connections with others.
authors.affiliation: Roudebush VA Medical Center, Day Hospital 116H, 1481 West 10th St, Indianapolis, Indiana 46202, USA. plysaker@iupui.edu
authors.forename: Paul H
authors.initials: PH
authors.lastname: Lysaker
authors.forename: Louanne W
authors.initials: LW
authors.lastname: Davis
mesh_terms: D000328:Adult; D003071:Cognition; D003631:Day Care, Medical; D006787:Hospitals, Veterans; D006801:Humans; D007196:Indiana; D007398:Interpersonal Relations; D008297:Male; D008875:Middle Aged; D010552:Personality Assessment; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D011599:Psychopathology; D011618:Psychotic Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012565:Schizophrenic Psychology; D012647:Self-Assessment; D012919:Social Behavior; D014728:Veterans / Q000523:psychology