SARS--beginning to understand a new virus.
The 114-day epidemic of the severe acute respiratory syndrome (SARS) swept 29 countries, affected a reported 8,098 people, left 774 patients dead and almost paralyzed the Asian economy. Aggressive quarantine measures, possibly aided by rising summer temperatures, successfully terminated the first eruption of SARS and provided at least a temporal break, which allows us to consolidate what we have learned so far and plan for the future. Here, we review the genomics of the SARS coronavirus (SARS-CoV), its phylogeny, antigenic structure, immune response and potential therapeutic interventions should the SARS epidemic flare up again.
Stadler
Konrad
K
IRIS, Chiron S.r.l., Via Fiorentina 1, 53100 Siena, Italy.
Masignani
Vega
V
Eickmann
Markus
M
Becker
Stephan
S
Abrignani
Sergio
S
Klenk
Hans-Dieter
HD
Rappuoli
Rino
R
D000818:Animals; D016679:Genome, Viral; D023281:Genomics; D006801:Humans; D010802:Phylogeny; D045473:Severe acute respiratory syndrome-related coronavirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology* / Q000628:therapy / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D014764:Viral Proteins