[GVHD gastro-duodenitis].
Graft-versus-host disease(GVHD) colitis after allogeneic bone marrow transplantation or peripheral blood stem cell transplantation was often accompanied with upper gastro-intestinal symptoms such as upper abdominal pain. We investigated 7 cases of gastro-duodenal lesions with GVHD colitis. Endoscopic features of gastric lesions with GVHD were turbidity(100%), erythema(100%), erosions(85.7%), easy bleeding of mucosa(71.4%) and duodenal involvement(71.4%), histological findings of those were infiltration of inflammatory cells(100%), dilatation of capillaries(100%), hemorrhage(71.4%), stromal edema(85.7%), degenerated glands and apoptotic bodies(100%). Those findings resembled with endoscopic and histological features of GVHD colitis, so we diagnosed those lesions as GVHD gastro-duodenitis. Clinically GVHD colitis with gastro-duodenitis was severe compared with colitis without gastro-duodenitis.
Funakoshi
Kazuhiro
K
Division of Internal Medicine, Niigata Cancer Center Hospital.
Kato
Toshiyuki
T
Ohta
Tamaki
T
D003092:Colitis / Q000209:etiology; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology* / Q000473:pathology