title: Influence of phloretin on the skin permeation of lidocaine from semisolid preparations.
abstract: The purpose of the present study was to determine the significance of phloretin on the topical permeation of lidocaine using different semisolid preparations as delivery systems. One hydrophilic and three lipophilic formulations were used. After estimation of the solubility of phloretin and lidocaine in the vehicles and analysis of the viscoelastic properties, standard diffusion experiments with Franz type diffusion cells through porcine skin were performed. Results indicate a general lidocaine enhancement by phloretin in the tested vehicles. The permeation was enhanced 1.39-fold in the hydrophilic formulation and between 1.25- and 1.76-fold in the lipophilic formulations.
authors.affiliation: Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Vienna, Austria.
authors.forename: Barbara
authors.initials: B
authors.lastname: Gabriele Auner
authors.forename: Claudia
authors.initials: C
authors.lastname: Valenta
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical; D066298:In Vitro Techniques; D008012:Lidocaine / Q000737:chemistry / Q000493:pharmacokinetics*; D010693:Phloretin / Q000737:chemistry / Q000493:pharmacokinetics*; D012869:Skin Absorption / Q000502:physiology*; D013552:Swine
chemical_list: D008012:Lidocaine; D010693:Phloretin