Inhibition of mast cell-dependent immediate-type hypersensitivity reactions by purple bamboo salt.
Purple bamboo salt is a specially processed salt according to the traditional recipe using normal salt and bamboo etc. It has been used as a folk medicine for the purpose of prevention and treatment of various diseases in Korea. This report describes an inhibitory effect of purple bamboo salt on mast cell-mediated immediate-type allergic reactions. Purple bamboo salt (0.01-1 microg per site) significantly inhibited the ear swelling response induced by intradermal injection of compound 48/80 in mice. Purple bamboo salt (0.01-1 mg/ml) dose-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMCs) by compound 48/80. Purple bamboo salt (0.01-1 g/kg) also dose-dependently inhibited the passive cutaneous anaphylaxis (PCA) by oral administration. Our results provide evidence that purple bamboo salt will be beneficial in the regulation of immediate-type of allergic reactions.
Shin
Hye-Young
HY
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
Na
Ho-Jeong
HJ
Moon
Phil-Dong
PD
Shin
Taekyun
T
Shin
Tae-Yong
TY
Kim
Sung Hoon
SH
Hong
Seung-Heon
SH
Kim
Hyung-Min
HM
D000818:Animals; D006632:Histamine / Q000378:metabolism; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007723:Korea; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D012492:Salts / Q000302:isolation & purification / Q000627:therapeutic use*; D031787:Sasa
D012492:Salts; D006632:Histamine