title: Changes in plasma levels of adhesion molecules after percutaneous mitral balloon valvuloplasty.
abstract: BACKGROUND
  Adhesion molecules are expressed on vascular endothelium and on immune and inflammatory cells. Recently increased levels of adhesion molecules have been shown in patients with rheumatic mitral stenosis. This study examined the serum levels of the adhesion molecules intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in patients with rheumatic mitral stenosis and the effects of percutaneous mitral balloon valvuloplasty (PMBV) on these adhesion molecules.
  
  
  METHODS
  Thirty five patients (3 men, 32 women, mean age 39+/-5 years) with severe rheumatic mitral stenosis who underwent percutaneous balloon mitral valvuloplasty, and 35 age and sex matched healthy control subjects were included in the study. Serum levels of ICAM-1, VCAM-1, and E-selectin were measured in all patients who underwent PMBV and in all control subjects. Blood samples were taken for measurement of adhesion molecules immediately before and 24 h after the mitral balloon valvuloplasty.
  
  
  RESULTS
  The plasma levels of soluble adhesion molecules E-selectin, ICAM-1 and VCAM-1 were significantly elevated in patients with mitral stenosis compared to control subjects: E-selectin, 97+/-59 vs. 45+/-24 ng/ml (P=.001), sICAM-1, 874+/-301 ng/ml vs. 238+/-82 ng/ml (P<.0001); sVCAM-1, 3056+/-763 ng/ml vs. 985+/-298 ng/ml (P<.0001). Plasma levels of VCAM-1 significantly increased 24 h after the valvuloplasty procedure (3056+/-763 ng/ml vs. 3570+/-1225 ng/ml P=.013). Plasma levels of E-selectin showed a significant decrease after PMBV (97+/-59 vs. 70+/-58 ng/ml, P=.043) and plasma levels of ICAM-1 did not show any change after PMBV (874+/-301 vs. 944+/-377 ng/ml, P=.356).
  
  
  CONCLUSIONS
  Cellular adhesion molecules, sICAM-1, E-selectin, sVCAM-1 have shown changes in different directions in response to PMBV. These results necessitate further studies to clarify the mechanism underlying the association between adhesion molecules and PMBV as well as rheumatic mitral stenosis.
authors.affiliation: Department of Cardiology, Inonu University School of Medicine, Malatya 44069, Turkey. eryetkin@ttnet.net.tr
authors.forename: Ertan
authors.initials: E
authors.lastname: Yetkin
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Erbay
authors.forename: Hasan
authors.initials: H
authors.lastname: Turhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Balci
authors.forename: Funda
authors.initials: F
authors.lastname: Yetkin
authors.forename: Gulay
authors.initials: G
authors.lastname: Yetkin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ileri
authors.forename: Kubilay
authors.initials: K
authors.lastname: Senen
authors.forename: Ramazan
authors.initials: R
authors.lastname: Atak
authors.forename: Sengul
authors.initials: S
authors.lastname: Cehreli
mesh_terms: D000328:Adult; D002404:Catheterization / Q000009:adverse effects*; D015815:Cell Adhesion Molecules / Q000097:blood*; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D008297:Male; D008946:Mitral Valve Stenosis / Q000097:blood* / Q000628:therapy*
chemical_list: D015815:Cell Adhesion Molecules