title: Bone marrow cell transplantation to the myocardium of a patient with heart failure due to Chagas' disease.
abstract: We report the first case of bone marrow cell transplantation to the myocardium of a patient with heart failure due to chagas' disease. The patient is a 52-year-old man with chronic heart failure, NYHA functional class III, despite the optimized clinical therapy. The procedure consisted of aspiration of 50 mL of bone marrow through puncture of the iliac crest, followed by filtration, separation of the mononuclear cells, resuspension, and intracoronary injection. The left ventricular ejection fraction at rest, measured using radionuclide ventriculography with labeled red blood cells prior to transplantation, was 24%, and, after 30 days, it increased to 32% with no change in the medicamentous schedule. The following measurements were assessed before and 30 days after transplantation: left ventricular end diastolic diameter (82 mm and 76 mm, respectively); Minnesota living with heart failure questionaire score (55 and 06, respectively); and distance walked in the 6-minute walking test (513 m and 683 m, respectively). Our findings show that intracoronary injection of bone marrow cells may be performed, suggesting that this is a potentially safe and effective procedure in patients with due to Chagas' disease heart failure.
authors.affiliation: Hospital Santa Izabel, Centro de Pesquisas Gonçalo Moniz, FIOCRUZ/BA, Salvador, BA, Brasil.
authors.forename: Fábio
authors.initials: F
authors.lastname: Vilas-Boas
authors.forename: Gilson Soares
authors.initials: GS
authors.lastname: Feitosa
authors.forename: Milena B P
authors.initials: MB
authors.lastname: Soares
authors.forename: Joel Alves
authors.initials: JA
authors.lastname: Pinho-Filho
authors.forename: Augusto
authors.initials: A
authors.lastname: Mota
authors.forename: Augusto José Gonçalves
authors.initials: AJ
authors.lastname: Almeida
authors.forename: Cristiane
authors.initials: C
authors.lastname: Carvalho
authors.forename: Heitor Ghissoni
authors.initials: HG
authors.lastname: de Carvalho
authors.forename: Adriano Dourado
authors.initials: AD
authors.lastname: de Oliveira
authors.forename: Ricardo Ribeiro
authors.initials: RR
authors.lastname: dos Santos
mesh_terms: D016026:Bone Marrow Transplantation; D002303:Cardiac Output, Low / Q000209:etiology / Q000601:surgery*; D002598:Chagas Cardiomyopathy / Q000150:complications / Q000601:surgery*; D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium