title: Cerebellar malignant fibrous histiocytoma: case report and literature review.
abstract: OBJECTIVE
  Malignant fibrous histiocytoma in the central nervous system is uncommon. Fewer than 70 cases have been documented and, to the best of our knowledge, this is the first case arising from the cerebellum.
  
  
  METHODS
  A 44-year-old woman presented with headaches, vomiting, and dizziness. A neurological examination revealed right cerebellar syndrome. Brain computed tomographic scans revealed an isodense tumor in the right cerebellar hemisphere. The breast ultrasonographic, bone scintigraphic, and thoracoabdominal computed tomographic findings were normal.
  
  
  METHODS
  The patient was surgically treated. The tumor recurred 1.5 months later, demonstrating hemorrhagic characteristics on brain computed tomographic scans. The patient underwent a second operation, followed by radiotherapy.
  
  
  CONCLUSIONS
  Malignant fibrous histiocytoma is still a controversial entity, and the lack of specific criteria means that it must be diagnosed via the process of elimination. With currently available therapy, our review can provide only a very poor prognosis. The median survival time was 27 months. In attempts to develop better therapeutic strategies, total excision and radiotherapy seem to represent the best treatment approach.
authors.affiliation: Department of Neurosurgery, Centre Hospitalier Régional Universitaire Pontchaillou, Rennes, France. hamlat.abd@wanadoo.fr
authors.forename: Abderrahmane
authors.initials: A
authors.lastname: Hamlat
authors.forename: Mahmoudreza
authors.initials: M
authors.lastname: Adn
authors.forename: Sylvie
authors.initials: S
authors.lastname: Caulet-Maugendre
authors.forename: Yvon
authors.initials: Y
authors.lastname: Guegan
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D009460:Neurologic Examination; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor