Potential applications of microbial surfactants in biomedical sciences.
The main commercial use of biosurfactants is in pollution remediation because of their ability to stabilize emulsions. This enhances the solubility and availability of hydrophobic pollutants, thus increasing their potential for biodegradation. One useful property of many biosurfactants that has not been reviewed extensively is their antimicrobial activity. Several biosurfactants have strong antibacterial, antifungal and antiviral activity. Other medically relevant uses of biosurfactants include their role as anti-adhesive agents to pathogens, making them useful for treating many diseases and as therapeutic and probiotic agents. Here, we discuss some of the new and exciting applications and related developments of various microbial surfactants in the field of biomedical sciences.
Singh
Pooja
P
Institute of Microbial Technology, Sector 39 A, Chandigarh 160036, India.
Cameotra
Swaranjit Singh
SS
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D001422:Bacterial Adhesion / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006017:Glycolipids / Q000737:chemistry / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D000998:Antiviral Agents; D005343:Fibrinolytic Agents; D006017:Glycolipids; D055666:Lipopeptides; D008074:Lipoproteins; D010455:Peptides; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C439671:mannosylerythritol lipid; C063729:pumilacidin; C009365:surfactin peptide; C013579:iturin A