Analgesic effects of crude extracts of Miconia albicans (Melastomataceae).
The present study describes the analgesic effects of the crude extracts (hexane, methylene chloride and ethanol) obtained from the aerial parts of Miconia albicans (Melastomataceae) using the writhing test and the hot plate models for pain in mice. The extracts in hexane and methylene chloride, given orally, produced significant antinociception in the writhing test. On the other hand, none of the extracts had a significant effect on the hot plate test, a fact suggesting that the substances present in the extracts may rather have peripheral analgesic activity.
Vasconcelos
M A Lemos
MA
Núcleo de Pesquisa em Ciências Exatas e Tecnológicas da Universidade de Franca--Pq. Universitário, Franca-SP, Brazil.
Ferreira
D da Silva
Dda S
Andrade e Silva
M L
ML
Veneziani
R Cassio Sola
RC
Cunha
W R
WR
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D008297:Male; D035322:Melastomataceae / Q000737:chemistry*; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents
D000700:Analgesics; D010936:Plant Extracts; D012997:Solvents