Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts.
The aqueous extracts of 24 herbs traditionally used as curing ischemic heart disease in clinic in China were screened for their in vitro angiogenic activity, another twenty-four traditionally used as anti-tumor or anti-inflammatory remedies in China were screened for their in vitro anti-angiogenic activity. The activity of angiogenesis was determined by quantitation of vessels on chick embryo chorioallantoic membrane (CAM) model and cell proliferation of cultured bovine aortic endothelial cells (BAECs). Among the herbal extracts examined, the aqueous extracts of Epimedium sagittatum, Trichosanthes kirilowii and Dalbergia odorifera showed the strong angiogenetic activity both in CAM and BAECs models; and the aqueous extracts of Berberis paraspecta, Catharanthus roseus, Coptis chinensis, Taxus chinensis, Scutellaria baicalensis, Polygonum cuspidatum and Scrophularia ningpoensis elicited significant inhibition at a concentration of 1g dry herb /ml.
Wang
Shanshan
S
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zheng
Zhengui
Z
Weng
Yinqi
Y
Yu
Yijun
Y
Zhang
Daifu
D
Fan
Weihu
W
Dai
Ruihong
R
Hu
Zhibi
Z
D000482:Allantois / Q000033:anatomy & histology / Q000378:metabolism; D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D020533:Angiogenesis Inhibitors / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002642:Chick Embryo; D002823:Chorion / Q000033:anatomy & histology / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D010936:Plant Extracts / Q000378:metabolism*
D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D010936:Plant Extracts; D005346:Fibroblast Growth Factors; D003907:Dexamethasone