Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog.
This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression, thus acting as a proapoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway.
Bencini
Stefania
S
Department of Pathologic Anatomy and Forensic Medicine, Section of Pathologic Anatomy, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Migaldi
Mario
M
Castagnetti
Giovanni
G
Pincelli
Carlo
C
Ferrari
Paolo
P
De Gaetani
Carmela
C
Trentini
Gian Paolo
GP
D017209:Apoptosis / Q000187:drug effects*; D015415:Biomarkers / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D011518:Proto-Oncogene Proteins / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; C107489:BIRC5 protein, human; D015415:Biomarkers; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D051028:bcl-2-Associated X Protein; D007987:Gonadotropin-Releasing Hormone