Yersinia pseudotuberculosis anti-inflammatory components reduce trinitrobenzene sulfonic acid-induced colitis in the mouse.
Rectal instillation of trinitrobenzene sulfonic acid (TNBS) induces acute colitis in the mouse. We tested the efficacy of Yersinia pseudotuberculosis anti-inflammatory components in preventing TNBS-triggered colitis. Animals were orally inoculated with virulence-attenuated Yersinia cells (a phoP mutant) prior to TNBS administration. Under these experimental conditions, colonic lesions and tumor necrosis factor alpha mRNA levels were significantly reduced.
Marceau
Michael
M
E0364 INSERM-Université de Lille II, Faculté de Médecine and Institut de Biologie de Lille, France.
Dubuquoy
Laurent
L
Caucheteux-Rousseaux
Christel
C
Foligne
Benoit
B
Desreumaux
Pierre
P
Simonet
Michel
M
D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000276:immunology* / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007249:Inflammation; D015212:Inflammatory Bowel Diseases / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D014302:Trinitrobenzenesulfonic Acid / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism; D015011:Yersinia pseudotuberculosis / Q000276:immunology* / Q000472:pathogenicity; D015012:Yersinia pseudotuberculosis Infections / Q000276:immunology*
D014409:Tumor Necrosis Factor-alpha; D014302:Trinitrobenzenesulfonic Acid