title: Integrated endoscopy system for simultaneous imaging and spectroscopy for early lung cancer detection.
abstract: An integrated endoscopy system for simultaneous imaging and spectroscopy was developed to facilitate more accurate and convenient detection of early lung cancers. A specially designed three-CCD camera in combination with a dedicated light source permits capture of both white-light color images and tissue autofluorescence images without the need to switch between two different cameras. A mirror with an optical fiber at its center, placed at an interim imaging plane inside the camera unit, facilitates simultaneous imaging and spectroscopy measurements in either white-light reflectance mode or fluorescence mode. The system has been successfully tested in a clinic, demonstrating a practical approach to improve both diagnostic sensitivity and specificity at the same time.
authors.affiliation: Cancer Imaging Department, BC Cancer Agency, 601 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada. hzeng@bccancer.bc.ca
authors.forename: Haishan
authors.initials: H
authors.lastname: Zeng
authors.forename: Mirjan
authors.initials: M
authors.lastname: Petek
authors.forename: Marjeta Tercelj
authors.initials: MT
authors.lastname: Zorman
authors.forename: Annette
authors.initials: A
authors.lastname: McWilliams
authors.forename: Branko
authors.initials: B
authors.lastname: Palcic
authors.forename: Stephen
authors.initials: S
authors.lastname: Lam
mesh_terms: D042241:Early Diagnosis; D019723:Endoscopes; D004724:Endoscopy / Q000379:methods; D004867:Equipment Design; D005336:Fiber Optic Technology; D005453:Fluorescence; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D055100:Optical Fibers; D010781:Photography / Q000295:instrumentation; D012542:Scattering, Radiation