title: Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes.
abstract: Macrophages and dendritic cells infiltrate tumours. In the tumour microenvironment, mononuclear phagocytes acquire properties of polarized M2 (or alternatively activated) macrophages. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Silvano
authors.initials: S
authors.lastname: Sozzani
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
authors.forename: Tiziana
authors.initials: T
authors.lastname: Schioppa
authors.forename: Alessandra
authors.initials: A
authors.lastname: Saccani
authors.forename: Paola
authors.initials: P
authors.lastname: Allavena
authors.forename: Antonio
authors.initials: A
authors.lastname: Sica
mesh_terms: D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology*; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D010586:Phagocytes / Q000502:physiology