Fashioning regulatory dendritic cells: what is currently in vogue?
Dendritic cells (DCs) are uniquely well-equipped antigen-presenting cells with remarkable plasticity, whose differentiation and function can be manipulated in vitro and in vivo. With increased understanding of their immunoregulatory properties, strategies to enhance DC tolerogenicity have emerged. Carefully fashioned DCs, the result of biological, pharmacological or genetic modification, hold promise as new cell-based therapies of organ allograft rejection and autoimmune diseases.
Taner
Timuçin
T
University of Pittsburgh Medical Center, Thomas E Starzl Transplantation Institute, Department of Surgery, 200 Lothrop Street, Biomedical Science Tower W1544, Pittsburgh, PA 15213, USA.
Thomson
Angus W
AW
D000818:Animals; D017951:Antigen Presentation; D001327:Autoimmune Diseases / Q000628:therapy; D015551:Autoimmunity; D002454:Cell Differentiation; D064987:Cell- and Tissue-Based Therapy; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000276:immunology*; D005818:Genetic Engineering; D006801:Humans; D007108:Immune Tolerance; D008954:Models, Biological; D023001:Transplantation Tolerance