[Strategic approach to glycohemoglobin determination].
The purpose of the case study was to design an approach involving the clinical use of glycated hemoglobin (GH) in patients with diabetes mellitus (DM). 139 patients with DM, types 1 and 2, were examined. GH was quantified by 4 methods, i.e. immunochemistry, colorimetry, by oxalic and phosphoric acids and by isoelectrofocusing. It was revealed by correlation and regression assays that the GH level made a non-linear bond and depended to a great extent on a daily glucosuria, daily proteinuria, total serum cholesterol, body weight index and disease duration. Whereas no such bond was found for accidental pre- and postprandial glycemias. The conclusion is that, with due respect to a comparative analysis of different techniques applicable to GH quantification, the discussed index still remains a reliable criterion of the profound metabolic conditions, and that argumentative methods must be used in its quantification.
Korolev
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D000293:Adolescent; D000328:Adult; D003124:Colorimetry; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007122:Immunoelectrophoresis; D007150:Immunohistochemistry; D008875:Middle Aged
D006442:Glycated Hemoglobin