title: Feasibility of a porcine adult intensive care model.
abstract: A porcine adult ICU model would be useful for several avenues of investigation relevant to the care of critically ill patients. The purpose of the experiments reported here was to test the feasibility of such a model, using healthy swine. Swine (n = 4; body weight, 76 +/- 5 kg) were instrumented with endotracheal, bladder, and central arterial and venous catheters, and were admitted to the intensive care unit (ICU) while undergoing mechanical ventilation under the continuous care of nurses. Cardiopulmonary parameters were monitored continuously, and serum biochemical parameters were measured intermittently. Survival was seven days in subject 1 and five and a half days in subject 2. Subjects 3 and 4 survived an abbreviated protocol (44 and 41 h, respectively). Care of the subjects was complicated by iatrogenic hemorrhage (n = 3), pneumonia (n = 2), and acute respiratory distress syndrome (n = 1). One subject was free of complications. Critically ill swine > or = 70 kg can survive mechanical ventilation in the ICU for up to seven days. When iatrogenic injury occurs, swine respond well to clinical care protocols. Further testing is needed to develop a reproducible model and determine whether healthy swine can survive the ICU environment for longer than 41 h.
authors.affiliation: University of Texas Health Science Center at Houston School of Nursing, 1100 Holcombe Boulevard, Suite 4.430, Houston, Texas 77030, USA.
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Hanneman
authors.forename: Fred J
authors.initials: FJ
authors.lastname: Clubb
authors.forename: Kathleen
authors.initials: K
authors.lastname: McKay
authors.forename: Gil
authors.initials: G
authors.lastname: Costas
mesh_terms: D000818:Animals; D002423:Cause of Death; D019963:Clinical Chemistry Tests; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000401:mortality; D004195:Disease Models, Animal; D005240:Feasibility Studies; D006403:Hematologic Tests; D007362:Intensive Care Units; D008297:Male; D011183:Postoperative Complications; D015203:Reproducibility of Results; D015996:Survival Rate; D013552:Swine / Q000502:physiology*; D012122:Ventilators, Mechanical / Q000009:adverse effects