title: Effect of Retama raetam on lipid metabolism in normal and recent-onset diabetic rats.
abstract: The purpose of this study was to examine the effect of single and repeated oral administration of the aqueous extract of Retama raetam (Forssk) Webb (RR) (20 mg/kg) on lipid metabolism in normal and streptozotocin-induced diabetic rats. In normal rats, the aqueous extract of RR induced a significant decrease of the plasma triglycerides concentrations one week after repeated oral administration (P<0.05). This reduction was maintained two weeks after once daily repeated oral administration (P<0.05). A significant decrease of plasma cholesterol levels was also observed one week (P<0.05) and two weeks (0.05) after repeated oral administration. In diabetic rats, RR treatment caused a significant decrease of plasma triglycerides levels after a single (P<0.05) and repeated (P<0.001) oral administration. A significant decrease of cholesterol levels was observed four hours after a single oral administration of the RR aqueous extract (P<0.05). One week after repeated oral administration of RR aqueous extract, the plasma cholesterol levels were significantly decreased (P<0.05) and still dropped after two weeks (P<0.005). On the other hand, the repeated oral administration of RR aqueous extract caused a significant decrease of body weight one week after repeated oral treatment in diabetic rats (P<0.05). We conclude that the aqueous extract of RR exhibits lipid and body weight lowering activities in both normal and severe hyperglycemic rats after repeated oral administration of RR aqueous extract at a dose of 20 mg/kg.
authors.affiliation: UFR Physiology of the Nutrition and Endocrinian Pharmacology, BP 688, Boutalamine, Errachidia, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Maghrani
authors.forename: A
authors.initials: A
authors.lastname: Lemhadri
authors.forename: N-A
authors.initials: NA
authors.lastname: Zeggwagh
authors.forename: A
authors.initials: A
authors.lastname: El Amraoui
authors.forename: M
authors.initials: M
authors.lastname: Haloui
authors.forename: H
authors.initials: H
authors.lastname: Jouad
authors.forename: M
authors.initials: M
authors.lastname: Eddouks
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000188:drug therapy; D007887:Fabaceae; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
chemical_list: D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol