Plant RNAi: How a viral silencing suppressor inactivates siRNA.
The three-dimensional structure of an siRNA bound to the tombusvirus p19 protein--a suppressor of gene silencing--provides a first glimpse into how plant viruses can defeat their host's anti-viral RNAi defenses.
Zamore
Phillip D
PD
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA. pnillip.zamore@umassmed.edu
D035683:MicroRNAs / Q000378:metabolism; D009690:Nucleic Acid Conformation; D010944:Plants / Q000821:virology*; D011487:Protein Conformation; D034622:RNA Interference / Q000502:physiology*; D034741:RNA, Small Interfering / Q000378:metabolism* / Q000502:physiology; D017864:Tombusvirus / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D035683:MicroRNAs; D034741:RNA, Small Interfering; D014764:Viral Proteins