[Comparative analysis of the functional activity of neutrophil granulocytes from blood of patients with renal cell carcinoma before and after the surgical treatment].
Patients with renal cell carcinoma (RCC) were examined by the chemiluminescent analysis before and after surgery. The cells of subjects with the discussed pathology were found to be in the state of functionally metabolic misbalance, i.e. an increased initial level of the synthesis of active oxygen with a relatively reduced cell reactivity when additionally stimulated. Such specificity of neutrophil granulocytes of peripheral blood is more pronounced in RCC patients after surgery. Supposedly, the above phenomenon is preconditioned by a lack of metabolic reserves that could provide an adequate functional response to extra stimulation and it develops due to a prolonged tumor progression and stress brought about by surgical intervention.
Shkapova
E A
EA
Kurtasova
L M
LM
Savchenko
A A
AA
Zukov
R A
RA
Krylova
G N
GN
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000601:surgery; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000601:surgery; D008163:Luminescent Measurements; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*