Influence of the concentrations of hyaluronic acid on the properties and biocompatibility of Cs-Gel-HA membranes.
The object of this study was to investigate the relationship between the concentrations of HA solutions and the physicochemical properties and the biocompatibility of Cs-Gel-HA membranes. The addition of different concentrations of HA not only improved the wettability significantly and extended the degradation time of Cs-Gel-HA membranes, but also changed their mechanical properties. The concentration of HA had a significant influence on the biocompatibility of Cs-Gel-HA membranes. Results demonstrated that it was only the concentrations of HA in a certain range (0.01-0.1%), that could promote the cell adhesion, migration and proliferation, while the concentration of HA was above 0.1% it would either reduce or even inhibit these behaviors.
Liu
Haifeng
H
Research Institute of Polymer Materials, Tianjin University, Tianjin 300072, People's Republic of China.
Yin
Yuji
Y
Yao
Kangde
K
Ma
Dongrui
D
Cui
Lei
L
Cao
Yilin
Y
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002586:Cesium / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D017886:Durapatite / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D005782:Gels / Q000737:chemistry; D006244:Hardness; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000494:pharmacology*; D008422:Materials Testing; D008567:Membranes, Artificial; D009113:Muramidase / Q000737:chemistry; D013718:Tensile Strength
D001672:Biocompatible Materials; D005782:Gels; D008567:Membranes, Artificial; D002586:Cesium; D006820:Hyaluronic Acid; D017886:Durapatite; D009113:Muramidase