Reversible diffusion MRI abnormalities and transient mutism after liver transplantation.
Transient mutism was observed in a liver transplant patient under immunosuppressant therapy with cyclosporine A and antifungal prophylaxis with amphotericin B. Fluid-attenuated inversion recovery and diffusion-weighted images revealed reversible bilateral symmetric hyperintensity located in the frontal motor cortex and corticospinal tracts. These MRI abnormalities may be caused by acute edema, possibly a combination of cytotoxic and vasogenic edema, which resolved with a prompt change in therapy.
Bianco
F
F
Department of Neurology, Neuroradiology Unit, General Surgery and Transplantation, University of Rome "La Sapienza," Italy. federico.bianco@uniroma1.it
Fattapposta
F
F
Locuratolo
N
N
Pierallini
A
A
Rossi
M
M
Ruberto
F
F
Bozzao
L
L
D038524:Diffusion Magnetic Resonance Imaging; D005625:Frontal Lobe / Q000473:pathology*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008103:Liver Cirrhosis / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009155:Mutism / Q000175:diagnosis* / Q000209:etiology; D011712:Pyramidal Tracts / Q000473:pathology*; D020127:Recovery of Function
D007166:Immunosuppressive Agents