title: [Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S 100].
abstract: The indication for an initial cranial computed tomography (CCT) in minor head trauma (MHT) patients remains the subject of discussion. The aim of this study was to investigate whether a newly developed, rapid test system (ELECSYS S100, Roche Diagnostics) might allow a diagnostically valid, reproducible measurement of S 100 in MHT patients. Blood samples were drawn from 75 MHT patients, a CCT scan was performed, and those with a post-traumatic intracranial lesion counted as CCT+. Results were compared to a healthy control group (n=17). Of the 75 patients included in the study, 14 were stratified as CCT+. The systemic concentration of S 100 in these CCT+ patients was significantly increased (0.31 microg/l) compared to the healthy control group (0.04 microg/l) as well as to the CCT-negative patients (0.08 microg/l). The ELECSYS S100 system allows a rapid, valid, and reproducible assessment of S 100B in patient serum and this concentration is significantly elevated in patients suffering from intracranial lesions as shown by initial CCT scan. Hence, this study is the basis for a multicenter trial currently underway to confirm the results of our pilot study.
authors.affiliation: Chirurgische Klinik und Poliklinik-Innenstadt, Ludwig-Maximilians-Universität, Nussbaumstrasse 20, 80336 Munich, Germany. peter.biberthaler@med.uni-muenchen.de
authors.forename: P
authors.initials: P
authors.lastname: Biberthaler
authors.forename: T
authors.initials: T
authors.lastname: Mussack
authors.forename: K-G
authors.initials: KG
authors.lastname: Kanz
authors.forename: U
authors.initials: U
authors.lastname: Linsenmaier
authors.forename: K-J
authors.initials: KJ
authors.lastname: Pfeifer
authors.forename: W
authors.initials: W
authors.lastname: Mutschler
authors.forename: M
authors.initials: M
authors.lastname: Jochum
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001929:Brain Edema / Q000145:classification / Q000175:diagnosis*; D020201:Brain Hemorrhage, Traumatic / Q000145:classification / Q000175:diagnosis*; D004630:Emergencies; D005260:Female; D016489:Head Injuries, Closed / Q000145:classification / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D012016:Reference Values; D015203:Reproducibility of Results; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity; D012887:Skull Fractures / Q000145:classification / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D009418:S100 Proteins