title: CD1d-mediated antigen presentation to natural killer T (NKT) cells.
abstract: CD1d molecules are lipid antigen-presenting molecules. They are involved in presenting these antigens to a unique subpopulation of T cells called natural killer T (NKT) cells, which have the capacity to produce both T helper (Th) 1 and Th2 cytokines. Thus, it is possible that the antigens presented by CD1d and/or the level at which they are presented could have profound effects on the immunoregulation of autoimmune and infectious diseases, as well as cancer. Because of the ability of CD1d-binding ligands to modulate NKT cell responses, targeting CD1d-mediated antigen presentation as a novel approach for new therapies in these and other diseases holds great promise.
authors.affiliation: Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, Building R2, Room 302, 950 W. Walnut St., Indianapolis, IN 46202-5181, USA. rbrutkie@iupui.edu
authors.forename: Randy R
authors.initials: RR
authors.lastname: Brutkiewicz
authors.forename: Yinling
authors.initials: Y
authors.lastname: Lin
authors.forename: Sungyoo
authors.initials: S
authors.lastname: Cho
authors.forename: Yu Kyeong
authors.initials: YK
authors.lastname: Hwang
authors.forename: Venkataraman
authors.initials: V
authors.lastname: Sriram
authors.forename: Tonya J
authors.initials: TJ
authors.lastname: Roberts
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D055610:Antigens, CD1d; D001327:Autoimmune Diseases / Q000188:drug therapy; D001424:Bacterial Infections / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D006017:Glycolipids / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007239:Infections / Q000188:drug therapy; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014443:Tyrosine / Q000737:chemistry; D014777:Virus Diseases / Q000276:immunology
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D016207:Cytokines; D006017:Glycolipids; D014443:Tyrosine