New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations.
Monodentate phosphoramidite ligands have been developed based on enantiopure 6,6'-dimethylbiphenols with axial chirality. These chiral ligands are easy to prepare and flexible for modifications. The fine-tuning capability of these ligands plays a significant role in achieving high enantioselectivity in the asymmetric hydroformylation of allyl cyanide and the conjugate addition of diethylzinc to cycloalkenones.
Hua
Zihao
Z
Department of Chemistry, Stony Brook University, Stony Brook, NY 11794-3400, USA.
Vassar
Victor C
VC
Choi
Hojae
H
Ojima
Iwao
I
D000498:Allyl Compounds / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D003512:Cyclohexanones / Q000737:chemistry; D005561:Formates / Q000737:chemistry; D008024:Ligands; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D017905:Phosphites / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
D000498:Allyl Compounds; D003486:Cyanides; D003512:Cyclohexanones; D005561:Formates; D008024:Ligands; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D010636:Phenols; D017905:Phosphites; C434331:phosphoramidite; D003300:Copper; D012238:Rhodium; D015032:Zinc