title: Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).
abstract: Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). Immunized monkeys developed anti-Abeta titers exceeding 1:1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta.
authors.affiliation: Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA 19107, USA. samgandy@earthlink.net
authors.forename: Sam
authors.initials: S
authors.lastname: Gandy
authors.forename: Ron B
authors.initials: RB
authors.lastname: DeMattos
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Lemere
authors.forename: Frank L
authors.initials: FL
authors.lastname: Heppner
authors.forename: Jodi
authors.initials: J
authors.lastname: Leverone
authors.forename: Adriano
authors.initials: A
authors.lastname: Aguzzi
authors.forename: William B
authors.initials: WB
authors.lastname: Ershler
authors.forename: Jinlu
authors.initials: J
authors.lastname: Dai
authors.forename: Paul
authors.initials: P
authors.lastname: Fraser
authors.forename: Peter
authors.initials: P
authors.lastname: St George Hyslop
authors.forename: David M
authors.initials: DM
authors.lastname: Holtzman
authors.forename: Lary C
authors.initials: LC
authors.lastname: Walker
authors.forename: Evan T
authors.initials: ET
authors.lastname: Keller
mesh_terms: D000375:Aging / Q000276:immunology*; D000544:Alzheimer Disease / Q000276:immunology* / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000097:blood; D005260:Female; D008253:Macaca mulatta; D010446:Peptide Fragments / Q000276:immunology*; D014612:Vaccines / Q000276:immunology / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D000906:Antibodies; D010446:Peptide Fragments; D014612:Vaccines; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)