Neural stem cells in the mammalian eye: types and regulation.
Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors.
Ahmad
Iqbal
I
Department of Ophthalmology, 11715 Lied Transplantation Center, University of Nebraska Medical Center, Omaha, NE 68198-7691, USA. iahmad@unmc.edu
Das
Ani V
AV
James
Jackson
J
Bhattacharya
Sumitra
S
Zhao
Xing
X
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology*; D002924:Ciliary Body / Q000166:cytology / Q000294:innervation; D005123:Eye / Q000166:cytology* / Q000294:innervation; D020869:Gene Expression Profiling; D006801:Humans; D008024:Ligands; D008322:Mammals / Q000196:embryology / Q000502:physiology; D008954:Models, Biological; D010857:Pigment Epithelium of Eye / Q000166:cytology / Q000294:innervation; D011956:Receptors, Cell Surface / Q000502:physiology; D012160:Retina / Q000166:cytology / Q000196:embryology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000032:analysis
D015415:Biomarkers; D008024:Ligands; D011956:Receptors, Cell Surface; D014157:Transcription Factors