The shark HoxN cluster is homologous to the human HoxD cluster.
The statistical analysis of phylogenetic footprints in the two known horn shark Hox clusters and the four mammalian clusters shows that the shark HoxN cluster is HoxD-like. This finding implies that the most recent common ancestor of jawed vertebrates had at least four Hox clusters, including those which are orthologous to the four mammalian Hox clusters.
Prohaska
Sonja J
SJ
Bioinformatik, Institut für Informatik, Universität Leipzig, Kreuzstrassse 7b, D-04103 Leipzig, Germany.
Fried
Claudia
C
Amemiya
Chris T
CT
Ruddle
Frank H
FH
Wagner
Günter P
GP
Stadler
Peter F
PF
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016000:Cluster Analysis; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D005801:Genes, Homeobox / Q000235:genetics*; D006801:Humans; D010802:Phylogeny; D017385:Sequence Homology; D012754:Sharks / Q000235:genetics*