F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.
Isoprostanes are a new class of lipids, isomers of conventional enzymatically derived prostaglandins, which are produced in vivo primarily by a free radical-catalyzed peroxidation of polyunsaturated fatty acids. F2-isoprostanes, isomers of the enzyme-derived prostaglandin F2alpha, are the most studied species. Because of their mechanisms of formation, specific structural features that distinguish them from other free radical-generated products and chemical stability, they provide a reliable index of the oxidative component of several diseases in vivo. Consistent data suggest that formation of F2-isoprostanes is indeed altered in a variety of clinical settings associated with inflammation and oxidant stress. Moreover, measurement of F2-isoprostanes might provide a sensitive biochemical basis of dose-selection in studies of natural and synthetic antioxidants.
Praticò
Domenico
D
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rokach
Joshua
J
Lawson
John
J
FitzGerald
Garret A
GA
D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D028421:Isoprostanes / Q000378:metabolism*; D015227:Lipid Peroxidation; D012307:Risk Factors
D028421:Isoprostanes