Serum iron, ferritin, transferrin, total iron binding capacity, hs-CRP, LDL cholesterol and magnesium in children; new reference intervals using the Dade Dimension Clinical Chemistry System.
BACKGROUND
We studied serum/Plasma iron, ferritin, transferrin concentrations, and total iron binding capacity (TIBC) in addition to highly sensitive C-reactive protein (hs-CRP), low-density lipoprotein (LDL) cholesterol and magnesium concentrations in a population of 800 in- and outpatients and defined new 95% reference intervals for pediatrics using the Dade Behring RxL Dimension Clinical Chemistry System.


METHODS
Plasma/serum concentrations of the above analytes were determined on patient samples accrued from January to June 2003 and the data were analyzed employing a computer adapted Hoffmann approach.


CONCLUSIONS
New pediatric reference intervals on the Dade RxL Dimension were obtained for serum iron, ferritin, transferrin, TIBC, hs-CRP, LDL-cholesterol and magnesium. This work represents the first hs-CRP data for children <3 years old. The values for all the analytes were established on new data (n=800). These values are new for hs-CRP and LDL cholesterol, while for iron, ferritin and magnesium these intervals are more reliable than those previously published by our group which had used regression equations on samples measured by the old (Vitros/Immuno1) methods for which intervals were available.
Soldin
Offie P
OP
Cancer, Genetics and Epidemiology and Endocrinology and Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA. offie@gwu.edu
Bierbower
Laura H
LH
Choi
James J
JJ
Choi
Jennifer J
JJ
Thompson-Hoffman
Savannah
S
Soldin
Steven J
SJ
D000293:Adolescent; D001774:Blood Chemical Analysis; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007501:Iron / Q000097:blood*; D033862:Iron-Binding Proteins / Q000097:blood*; D008274:Magnesium / Q000097:blood*; D008297:Male; D012016:Reference Values; D014168:Transferrin / Q000378:metabolism
D008078:Cholesterol, LDL; D033862:Iron-Binding Proteins; D014168:Transferrin; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron; D008274:Magnesium