[Synthesis and immunostimulating activity of cysteine-containing glycopeptide derivatives of glycyrrhizic acid].
New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBu(t) dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-type hypersensitivity in mice at a dose of 2 mg/kg. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.
Kondratenko
R M
RM
Bashkortostan State Medical University, Ufa, Bashkortostan, 450074 Russia.
Baltina
L A
LA
Vasil'eva
E V
EV
Baltina
L A
LA
Ismagilova
A F
AF
Nasyrov
Kh M
KhM
Baschenko
N Zh
NZh
Kireeva
R M
RM
Fridman
S M
SM
Tolstikov
G A
GA
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003545:Cysteine / Q000737:chemistry*; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019695:Glycyrrhizic Acid / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
D000276:Adjuvants, Immunologic; D006020:Glycopeptides; D019695:Glycyrrhizic Acid; D003545:Cysteine