The high affinity receptor for IgE, FcepsilonRI.
Progress in our understanding of the structure and function of the receptor with high affinity for IgE (FcepsilonRI) is already being applied in attempts to mitigate allergic reactions, specifically by using specific anti-IgEs to prevent sensitization. Investigations of the complex network of intracellular signals generated by FcepsilonRI and related receptors are proceeding. Although achieving a 'complete' description of the events will be a daunting task, the effort is likely to identify additional targets for therapeutic intervention along the way.
Metzger
Henry
H
NIAMS, NIH, Room 9N-228 10 Center Drive MSC 1820, Bethesda, MD 20892-1820, USA.
D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000737:chemistry / Q000378:metabolism*; D018448:Models, Immunological; D011940:Receptor Aggregation / Q000502:physiology; D017455:Receptors, IgE / Q000737:chemistry / Q000378:metabolism*
D017455:Receptors, IgE; D007073:Immunoglobulin E