Pattern of cerebral edema and hemorrhage in a mice model of diffuse brain injury.
This study aims to examine the time course of the brain edema formation in relation with blood-brain barrier (BBB) disruption and cerebral hemorrhage in a murine model of diffuse brain injury. Brain water content increased at 1 h post-injury and persisted up to 7 days. This event was associated with electrolyte imbalance such as Na(+) increase within 24 h. Prominent Evans blue extravasation was also observed from 1 to 6 h post-injury. Concurrently, hemoglobin increased markedly by 1 h, reached a peak at 4 h and declined progressively within a week in association with a rise of parenchyma iron content between 24 h and 7 days. These results suggest that brain edema is vasogenic and that the hemorrhage process is involved in the BBB disruption and edema, both leading to post-traumatic secondary events.
Hellal
F
F
UPRES EA2510, Laboratoire de Pharmacologie, Université René Descartes, 4 avenue de l'Observatoire, F-75006 Paris, France.
Bonnefont-Rousselot
D
D
Croci
N
N
Palmier
B
B
Plotkine
M
M
Marchand-Verrecchia
C
C
D000818:Animals; D001812:Blood-Brain Barrier / Q000503:physiopathology; D001834:Body Water / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D018450:Disease Progression; D005070:Evans Blue; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D014883:Water-Electrolyte Imbalance / Q000209:etiology / Q000503:physiopathology
D006454:Hemoglobins; D005070:Evans Blue; D007501:Iron