title: Efficient solid-phase synthesis of clavulones via sequential coupling of alpha- and omega-chains.
abstract: We describe an efficient solid-phase synthesis of clavulones via the sequential coupling of the alpha- and omega-chains, involving two separate carbon-carbon bond-forming steps. The tetrahydropyranyl linker survived these reaction conditions and was cleaved without decomposing the unstable cross-conjugated dienones. Our methodology has allowed us to prepare six clavulone derivatives that are varied within the alpha-chain.
authors.affiliation: Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Iwashima
authors.forename: Kazuo
authors.initials: K
authors.lastname: Iguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takahashi