Twist genes regulate Runx2 and bone formation.
Runx2, a master regulator of osteoblast differentiation, is expressed several days before osteoblast genes in bone anlage. In this issue of Developmental Cell, show that Twist-1 and Twist-2 suppress the activity of Runx2 and thereby regulate bone formation.
Kronenberg
Henry M
HM
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA.
D000818:Animals; D050659:Core Binding Factor Alpha 1 Subunit; D051379:Mice; D009363:Neoplasm Proteins / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D051879:Twist-Related Protein 1
D050659:Core Binding Factor Alpha 1 Subunit; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D051879:Twist-Related Protein 1