title: Investigations of the marine flora and fauna of the Islands of Palau.
abstract: The Islands of Palau have proven to be an excellent source of bioactive marine natural products primarily as a result of the systematic studies from the late 1970s by the research groups of Scheuer at the University of Hawaii, Faulkner at the Scripps Oceanographic Institution/University of California at San Diego, and Paul at the University of Guam. Their efforts were materially aided by the excellent facilities provided by the Government of Palau and for the last 10 years, those of the NCI's shallow water collection contractor, the Coral Reef Research Foundation. This review covers the structures and biological activities where noted, of the multitudinous marine-derived natural products isolated from the marine flora and fauna of this nation and demonstrates the enormous variety of novel structures elaborated by these organisms.
authors.affiliation: Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, NCI-Frederick, Frederick, MD 21702, USA.
authors.forename: D
authors.initials: D
authors.lastname: John Faulkner
authors.forename: David J
authors.initials: DJ
authors.lastname: Newman
authors.forename: Gordon M
authors.initials: GM
authors.lastname: Cragg
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D008974:Mollusca / Q000737:chemistry; D010140:Pacific Ocean; D019029:Palau; D010944:Plants / Q000737:chemistry; D011161:Porifera / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D001685:Biological Factors