HLA-A2-restricted CD8+-cytotoxic-T-cell responses to novel epitopes in Mycobacterium tuberculosis superoxide dismutase, alanine dehydrogenase, and glutamine synthetase.
Major histocompatibility complex class I-restricted CD8(+) cytotoxic T lymphocytes (CTL) are implicated in protective Th1 immunity to Mycobacterium tuberculosis infection. We report the identification of three novel HLA-A*0201-restricted CTL epitopes within mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins.
Dong
Yuzhi
Y
Laboratory of Molecular Immunology, Public Health Research Institute, Newark, New Jersey 07103, USA.
Demaria
Sandra
S
Sun
Xuming
X
Santori
Fabio R
FR
Jesdale
Bill M
BM
De Groot
Anne S
AS
Rom
William N
WN
Bushkin
Yuri
Y
D050788:Alanine Dehydrogenase; D000594:Amino Acid Oxidoreductases / Q000737:chemistry* / Q000276:immunology; D000595:Amino Acid Sequence; D018984:Epitopes, T-Lymphocyte; D005974:Glutamate-Ammonia Ligase / Q000737:chemistry* / Q000276:immunology; D015789:HLA-A2 Antigen / Q000378:metabolism*; D006801:Humans; D016056:Immunodominant Epitopes; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000201:enzymology / Q000276:immunology*; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D018984:Epitopes, T-Lymphocyte; D015789:HLA-A2 Antigen; D016056:Immunodominant Epitopes; D013482:Superoxide Dismutase; D000594:Amino Acid Oxidoreductases; D050788:Alanine Dehydrogenase; D005974:Glutamate-Ammonia Ligase