Selenoprotein synthesis and side-effects of statins.
Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated that the mechanism lay in a well established, but often overlooked, biochemical pathway--the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects and side-effects of statins, in particular, statin-induced myopathy.
Moosmann
Bernd
B
Department of Pathobiochemistry, Johannes Gutenberg University, Medical School, Mainz, Germany.
Behl
Christian
C
D003327:Coronary Disease / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000517:prevention & control; D008954:Models, Biological; D009135:Muscular Diseases / Q000139:chemically induced* / Q000378:metabolism; D011115:Polyneuropathies / Q000139:chemically induced / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism; D012206:Rhabdomyolysis / Q000139:chemically induced / Q000378:metabolism; D012643:Selenium / Q000172:deficiency / Q000378:metabolism; D051140:Selenoproteins
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011506:Proteins; D051140:Selenoproteins; D012643:Selenium