title: 19F-magnetic resonance spectroscopy in patients with liver metastases of colorectal cancer treated with 5-fluorouracil.
abstract: The purpose of this study was to examine the uptake and metabolism of 5-fluorouracil (5-FU) in human liver metastases. Patients with liver metastases of colorectal cancer were treated with 5-FU (500/600 mg/m)+folinic acid with or without trimetrexate. The clinical application of F-magnetic resonance spectroscopy (MRS) of 5-FU in a random group of patients (n=17) was investigated. MR spectra of all patients showed 5-FU and catabolite resonances, and fluoronucleotides were also seen in seven patients. A correlation was found between maximum levels of 5-FU catabolites as measured by F-MRS and response in a group with larger metastases. However, such correlation was not observed in a group with smaller metastases, probably because of a significant contribution of normal liver tissue to the MR spectra.
authors.affiliation: Department of Medical Oncology, University Medical Center Nijmegen, Nijmegen, The Netherlands. y.kamm@onco.umcn.nl
authors.forename: Yvonne J L
authors.initials: YJ
authors.lastname: Kamm
authors.forename: Arend
authors.initials: A
authors.lastname: Heerschap
authors.forename: Erik J
authors.initials: EJ
authors.lastname: van den Bergh
authors.forename: D J Theo
authors.initials: DJ
authors.lastname: Wagener
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005462:Fluorine Radioisotopes / Q000378:metabolism; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000556:secondary*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D005462:Fluorine Radioisotopes; D005472:Fluorouracil