title: The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.
abstract: In order to reveal the mechanisms underlying genistein combined polysaccharide (GCP) inhibition of tumor proliferation, we investigated the effects of GCP on the growth of human breast cancer cells transplanted to athymic nude mice. We further investigated the metabolism of genistein and its association with the beta-glucuronidase activity in tumor and normal tissues.
authors.affiliation: Laboratory of Biochemistry, Amino Up Chemical Company, Limited, Sapporo 004-0839, Japan. yuanlan@hotmail.com
authors.forename: Lan
authors.initials: L
authors.lastname: Yuan
authors.forename: Chihiro
authors.initials: C
authors.lastname: Wagatsuma
authors.forename: Buxiang
authors.initials: B
authors.lastname: Sun
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D005434:Flow Cytometry; D019833:Genistein / Q000494:pharmacology*; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*; D014183:Transplantation, Heterologous
chemical_list: D011134:Polysaccharides; C473311:genistein combined polysaccharide; D019833:Genistein; D005966:Glucuronidase