Increased cell-free DNA in plasma of patients with metastatic spread in prostate cancer.
We compared the plasma DNA concentrations in patients with different prostate cancer (PCa) stages and with benign prostate hyperplasia (BPH) and in healthy persons. Patients with localized cancer had DNA plasma within the reference interval. Increased plasma DNA was found in patients with lymph node and distant metastases and also in BPH. The association between plasma DNA and the survival time was similarly strong as with prostate-specific antigen. It can be concluded that plasma DNA has a limited validity as metastatic marker in PCa patients but follow-up studies combined with the investigation of tumor-related characteristics of plasma DNA would be reasonable.
Jung
Klaus
K
Department of Urology, University Hospital Charité, Humboldt University, Schumannstrasse 20/21, D-10098 Berlin, Germany. klaus.jung@charite.de
Stephan
Carsten
C
Lewandowski
Michaela
M
Klotzek
Silke
S
Jung
Monika
M
Kristiansen
Glen
G
Lein
Michael
M
Loening
Stefan A
SA
Schnorr
Dietmar
D
D004247:DNA / Q000097:blood*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology
D004247:DNA; D017430:Prostate-Specific Antigen