title: Osteosarcoma of the pelvis.
abstract: OBJECTIVE
  To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment.
  
  
  METHODS
  We reviewed 60 consecutive patients with primary pelvic high-grade osteosarcoma. The tumour involved the whole hemipelvis in 15 cases, while the most common location was the iliac wing in 29 cases (48.3%): 25 of these adjacent to or passing the sacroiliac joint.
  
  
  RESULTS
  Thirty patients underwent surgery; there were 16 hindquarter amputations and 14 internal hemipelvectomies. All the patients who presented with metastasis died of their disease. In 18 cases wide margins were achieved, however, eight patients experienced local recurrence. Of the series, only eight patients are still alive.
  
  
  CONCLUSIONS
  The use of intense chemotherapy and surgical wide margin, hardly seems to achieve local control, however, tumour necrosis was correlated with positive prognosis. When internal hemipelvectomy it is not safe enough, amputation must be considered, particularly for cases with sacrifice of the sciatic nerve roots or for older patients where a shorter surgical procedure can be less risky.
authors.affiliation: Department of Musculoskeletal Oncology and Orthopaedic Surgery, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy. davide.donati@ior.it
authors.forename: D
authors.initials: D
authors.lastname: Donati
authors.forename: S
authors.initials: S
authors.lastname: Giacomini
authors.forename: E
authors.initials: E
authors.lastname: Gozzi
authors.forename: S
authors.initials: S
authors.lastname: Ferrari
authors.forename: L
authors.initials: L
authors.lastname: Sangiorgi
authors.forename: A
authors.initials: A
authors.lastname: Tienghi
authors.forename: H
authors.initials: H
authors.lastname: DeGroot
authors.forename: F
authors.initials: F
authors.lastname: Bertoni
authors.forename: P
authors.initials: P
authors.lastname: Bacchini
authors.forename: G
authors.initials: G
authors.lastname: Bacci
authors.forename: M
authors.initials: M
authors.lastname: Mercuri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical / Q000379:methods; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000556:secondary / Q000628:therapy*; D010386:Pelvic Neoplasms / Q000473:pathology / Q000628:therapy*; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome