title: Choroidal neovascularization.
abstract: OBJECTIVE
  To review clinicopathologic findings of choroidal neovascularization (CNV) in a historical framework with emphasis on pathobiology and correlation with treatment.
  
  
  METHODS
  Selective literature review combined with authors' experience.
  
  
  RESULTS
  Choroidal neovascularization represents a stereotypic, nonspecific response to a specific stimulus. Although CNV differs among patients, the general growth patterns are subretinal pigment epithelium (type 1), subretinal (type 2), or combined. Choroidal neovascularization occurs over time in dynamic stages of initiation, active and involutional. Treatments are now being designed based on modern understanding of CNV growth.
  
  
  CONCLUSIONS
  Progress continues to be made concerning understanding the pathobiology and treatment of CNV.
authors.affiliation: Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: W Richard
authors.initials: WR
authors.lastname: Green
mesh_terms: D020256:Choroidal Neovascularization / Q000473:pathology / Q000628:therapy; D006801:Humans