title: Pi-delocalized beta-carbolinium cations as potential antimalarials.
abstract: Several beta-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral beta-carbolines and a good correlation was observed between pi-delocalized lipophilic cationic structure and antimalarial efficacy.
authors.affiliation: Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan. kay-t@mail.pharm.tohoku.ac.jp
authors.forename: Kiyosei
authors.initials: K
authors.lastname: Takasu
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Shimogama
authors.forename: Chalerm
authors.initials: C
authors.lastname: Saiin
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wataya
authors.forename: Masataka
authors.initials: M
authors.lastname: Ihara
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry* / Q000494:pharmacology*; D002412:Cations; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development
chemical_list: D000962:Antimalarials; D002243:Carbolines; D002412:Cations