title: Acute motor axonal neuropathy after Mycoplasma infection: Evidence of molecular mimicry.
abstract: BACKGROUND
  Patients with Guillain-Barré syndrome (GBS) after Mycoplasma pneumoniae infection often have antibodies to galactocerebroside (GalC). Electrodiagnosis may show acute inflammatory demyelinating polyneuropathy (AIDP).
  
  
  METHODS
  The authors report a patient with acute motor axonal neuropathy (AMAN) after Mycoplasma infection and review seven cases of Mycoplasma-associated GBS. They investigated anti-GalC serology under various conditions associated with Mycoplasma infection.
  
  
  RESULTS
  The patient had immunoglobulin (Ig)G and IgM antibodies against GM1 and GalC, which cross-reacted. During the acute phase, IgM selectively immunostained axons. The cholera toxin B-subunit and rabbit anti-GM1 IgG stained a band in the lipid extract from M pneumoniae, indicative of the presence of a GM1 epitope. Six Mycoplasma-associated GBS patients with anti-GalC antibodies had non-AIDP electrodiagnoses, whereas one with Mycoplasma-associated AIDP had no anti-GalC antibodies. Anti-GalC antibodies were positive in two of five patients who had neurologic diseases other than GBS after Mycoplasma infection and in one of 12 who had acute respiratory disease caused by M pneumoniae not followed by a neurologic disease.
  
  
  CONCLUSIONS
  Anti-GalC antibodies in Mycoplasma-associated GBS may be an epiphenomenon. In certain cases, anti-GM1 antibodies induced by molecular mimicry with M pneumoniae may cause acute motor axonal neuropathy.
authors.affiliation: Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan. ksusuki@dokkyomed.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Susuki
authors.forename: M
authors.initials: M
authors.lastname: Odaka
authors.forename: M
authors.initials: M
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: N
authors.initials: N
authors.lastname: Yuki
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001369:Axons / Q000276:immunology* / Q000473:pathology; D003429:Cross Reactions / Q000276:immunology; D004568:Electrodiagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005677:G(M1) Ganglioside / Q000276:immunology; D005699:Galactosylceramides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D018716:Molecular Mimicry / Q000276:immunology*; D009175:Mycoplasma Infections / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D009431:Neural Conduction; D011817:Rabbits; D051381:Rats; D012698:Serologic Tests
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D005699:Galactosylceramides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D005677:G(M1) Ganglioside