title: Acute lymphoblastic leukemia with hypereosinophilia: report of a case with 5q deletion and review of the literature.
abstract: Peripheral blood eosinophilia as a presentation of acute lymphoblastic leukemia (ALL) has only rarely been reported. The eosinophilia is thought to be a nonneoplastic reaction to the neoplastic lymphoblasts. We present the case of a 5-year-old girl who developed peripheral hypereosinophilia with no circulating blasts prior to her diagnosis of B-cell lineage ALL. Cytogenetic study showed a hyperdiploid blast population with 5q deletion. Persistent peripheral hypereosinophilia should always be fully investigated, the possibility of a malignancy including ALL needs to be excluded, even in the absence of peripheral cytopenias and circulating blasts.
authors.affiliation: Section of Hematology/Oncology, Columbus Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
authors.forename: Tung T
authors.initials: TT
authors.lastname: Wynn
authors.forename: Nyla A
authors.initials: NA
authors.lastname: Heerema
authors.forename: Sue
authors.initials: S
authors.lastname: Hammond
authors.forename: Mark
authors.initials: M
authors.lastname: Ranalli
authors.forename: Samir B
authors.initials: SB
authors.lastname: Kahwash
mesh_terms: D002675:Child, Preschool; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D011014:Pneumonia / Q000209:etiology* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D017384:Sequence Deletion