Accessing natural products by combinatorial biosynthesis.
Enhancement and selective production of the protein phosphatase IIa inhibitor phoslactomycin (PLM) B by rational engineering of the PLM biosynthetic pathway highlights the effectiveness of combinatorial biosynthesis as a promising way to prepare complex natural products and their analogs.
Shen
Ben
B
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. bshen@pharmacy.wisc.edu
D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends*; D012107:Research Design / Q000639:trends*