title: Diastereoselective aldol reaction of N,N-dibenzyl-alpha-amino aldehydes with ketones catalyzed by proline.
abstract: [reaction: see text] L-proline-catalyzed direct aldol reaction of L-amino acid-derived N,N-dibenzyl amino aldehydes with acetone, cyclopentanone, or hydroxyacetone provides gamma-amino-beta-hydroxy- or gamma-amino-alpha,beta-dihydroxy-ketones with moderate to excellent yields and diastereoselectivities.
authors.affiliation: Department of Chemistry, Fudan University, Shanghai 200433, China.
authors.forename: Qiangbiao
authors.initials: Q
authors.lastname: Pan
authors.forename: Benli
authors.initials: B
authors.lastname: Zou
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wang
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D007202:Indicators and Reagents; D007659:Ketones / Q000138:chemical synthesis*; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007202:Indicators and Reagents; D007659:Ketones; C116609:3-hydroxybutanal; D011392:Proline