Non-linearity in combined effects of ELF magnetic field and amphetamine on motor activity in rats.
The effects of short-term (15 min) pre-exposure of rats to extremely low-frequency magnetic field (ELF-MF, 50 Hz, 6 mT) on their motor (locomotor and stereotypic) activity induced by d-amphetamine sulphate (AMPH) at different doses (0.5, 1.5 and 4.5mg/kg, i.p.) were studied in the open field test. In saline-treated rats both parameters of motor activity were unaffected by ELF-MF irradiation. The rats pre-exposed to ELF-MF and injected with the lowest dose of AMPH showed the same locomotor activity as control animals, while their stereotypic behaviour was significantly elevated. ELF-MF in combination with AMPH at higher doses significantly enhanced motor activity when compared with values obtained in both control and combined experiments with the lowest dose of the drug. However, only combined locomotor effect at the middle dose of AMPH was significantly greater than those observed in corresponding experiments with AMPH alone. These results demonstrate that acute short-term exposure to ELF-MF is able to modify a motor activity in dependence on the extent of AMPH-induced neurotransmitter imbalance.
Pesić
Vesna
V
Laboratory of Electrophysiology and Behaviour, Department of Neurobiology and Immunology, Institute for Biological Research, 29 Novembra 142, 11060 Belgrade, Serbia and Montenegro, Yugoslavia.
Janać
Branka
B
Jelenković
Ankica
A
Vorobyov
Vasily
V
Prolić
Zlatko
Z
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004574:Electromagnetic Fields; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D013239:Stereotyped Behavior / Q000187:drug effects / Q000528:radiation effects
D000697:Central Nervous System Stimulants; D000661:Amphetamine