Multiple roles for ISWI in transcription, chromosome organization and DNA replication.
ISWI functions as the ATPase subunit of multiple chromatin-remodeling complexes. These complexes use the energy of ATP hydrolysis to slide nucleosomes and increase chromatin fluidity, thereby modulating the access of transcription factors and other regulatory proteins to DNA. Here we discuss recent progress toward understanding the biological functions of ISWI, with an emphasis on its roles in transcription, chromosome organization and DNA replication.
Corona
Davide F V
DF
Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, 350 Sinsheimer Labs, Santa Cruz, CA 95064, USA.
Tamkun
John W
JW
D000251:Adenosine Triphosphatases / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D042002:Chromatin Assembly and Disassembly; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D004261:DNA Replication; D005786:Gene Expression Regulation; D006801:Humans; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
C086468:ISWI protein; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases