title: Kinase chemogenomics: targeting the human kinome for target validation and drug discovery.
abstract: Chemogenomics is a gene family-based approach to drug discovery and target validation. This review will summarize the application of this interdisciplinary approach to the protein kinases of the human genome with emphasis upon the synergies and efficiencies to be gained. Specific examples from the SAPK-family will be discussed.
authors.affiliation: Vertex Pharmaceuticals, Inc., 130 Waverly Street, Cambridge, Massachusetts 02139, USA. Harbeson@vpharm.com
authors.forename: E
authors.initials: E
authors.lastname: ter Haar
authors.forename: W P
authors.initials: WP
authors.lastname: Walters
authors.forename: S
authors.initials: S
authors.lastname: Pazhanisamy
authors.forename: P
authors.initials: P
authors.lastname: Taslimi
authors.forename: A C
authors.initials: AC
authors.lastname: Pierce
authors.forename: G W
authors.initials: GW
authors.lastname: Bemis
authors.forename: F G
authors.initials: FG
authors.lastname: Salituro
authors.forename: S L
authors.initials: SL
authors.lastname: Harbeson
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry*; D015894:Genome, Human; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010597:Pharmacogenetics; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D008024:Ligands; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases