title: Evaluation of chest motion and volumetry during the breathing cycle by dynamic MRI in healthy subjects: comparison with pulmonary function tests.
abstract: OBJECTIVE
  To investigate diaphragm and chest wall motion during the whole breathing cycle using magnetic resonance imaging (MRI) and a volumetric model in correlation with spirometry.
  
  
  METHODS
  Breathing cycles of 15 healthy volunteers were examined using a trueFISP sequence (5 slices in 3 planes, 3 images per second). Time-distance curves were calculated and correlated to spirometry. A model for vital capacity (VC), continuous time-dependent vital capacity (tVC), and investigating the influence of horizontal and vertical parameters on tVC was introduced.
  
  
  RESULTS
  Time-distance curves of the breathing cycle using MRI correlated highly significant with spirometry (P < 0.0001). VC calculated by the model was similar to VC measured in spirometry (5.00 L vs. 5.15 L). tVC correlated highly significantly with spirometry (P < 0.0001). Vertical parameters had a more profound influence on tVC change than horizontal parameters.
  
  
  CONCLUSIONS
  Dynamic MRI is a simple noninvasive method to evaluate local chest wall motion and respiratory mechanics. It widens the repertoire of tools for lung examination with a high temporal resolution.
authors.affiliation: Department of Radiology, Therapy, German Cancer Research Center Heidelberg, Heidelberg, Germany. c.plathow@dkfz.de
authors.forename: Christian
authors.initials: C
authors.lastname: Plathow
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ley
authors.forename: Christian
authors.initials: C
authors.lastname: Fink
authors.forename: Michael
authors.initials: M
authors.lastname: Puderbach
authors.forename: Melanie
authors.initials: M
authors.lastname: Heilmann
authors.forename: Ivan
authors.initials: I
authors.lastname: Zuna
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Kauczor
mesh_terms: D000328:Adult; D003964:Diaphragm / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009068:Movement; D012016:Reference Values; D012119:Respiration; D013147:Spirometry; D035441:Thoracic Wall / Q000502:physiology*; D014797:Vital Capacity