[Relationship between expression of matrix metalloproteinase-9 (MMP-9) and angiogenesis in renal cell carcinoma].
OBJECTIVE
Matrix metalloproteinase-9 (MMP-9) is closely related to tumor invasion and metastasis. It has been recently found that MMP-9 also plays a role in tumor angiogenesis. This study was designed to investigate the relationship between MMP-9 and angiogenesis in renal cell carcinoma (RCC) and its clinical significance.


METHODS
SP immunohistochemistry was used to determine the expression of MMP-9, vascular endothelial growth factor (VEGF), and microvessel density (MVD) in 78 RCC tissues.


RESULTS
The expression of MMP-9 was related to the pathological stage and the histological grade in RCC (P< 0.05). The MVD value in MMP-9-positive group (110.46+/-50.16) was much higher than that in MMP-9-negative group (84.77+/-44.52)(P< 0.05). There was a positive correlation between the intensity of the expression of MMP-9 and that of VEGF in RCC tissues (r=0.4096,P< 0.01). MMP-9 and VEGF took synergistic effect on angiogenesis in RCC.


CONCLUSIONS
MMP-9 is associated with angiogenesis in RCC, and can serve as a biomarker for the potentialities of invasion and metastasis of RCC.
Zhang
Yao
Y
Department of Urology, The First Affiliated Hospital of Chongqing University of Medicine Sciences, Chongqing, 400016, PR China.
Wu
Xiao-Hou
XH
Cao
Gui-Hua
GH
Li
Shun
S
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000098:blood supply / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000098:blood supply / Q000201:enzymology* / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology*; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D042461:Vascular Endothelial Growth Factor A; D020780:Matrix Metalloproteinase 9