Effectiveness of cardiac surgery in trisomies 13 and 18 (from the Pediatric Cardiac Care Consortium).
Because of severely reduced lifespan in children with trisomies 13 and 18, surgical repair of congenital heart lesions has rarely been offered. With data from a multicenter registry, we report 35 cases of cardiac surgery in infants and children with trisomy 13 or 18 with a 91% hospital survival rate. Those patients without an extended preoperative ventilatory requirement did not require prolonged mechanical ventilation after surgery.
Graham
Eric M
EM
Division of Pediatric Cardiology, Charleston, South Carolina 29425, USA. atzam@musc.edu
Bradley
Scott M
SM
Shirali
Girish S
GS
Hills
Christine B
CB
Atz
Andrew M
AM
D002170:Canada / Q000453:epidemiology; D006348:Cardiac Surgical Procedures / Q000706:statistics & numerical data; D002648:Child; D002675:Child, Preschool; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D005060:Europe / Q000453:epidemiology; D005260:Female; D006330:Heart Defects, Congenital / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011183:Postoperative Complications; D012042:Registries; D012121:Respiration, Artificial; D012189:Retrospective Studies; D016019:Survival Analysis; D014314:Trisomy; D014481:United States / Q000453:epidemiology