title: Implementation of the Prostate Cancer Prevention Trial (PCPT).
abstract: The Prostate Cancer Prevention Trial is a randomized double blind chemoprevention trial of 18,882 men. It is designed to test the difference in the histologically proven prostate cancer prevalence between a group of participants given finasteride and another given placebo for 7 years. We present an overview of the study design, details of the administrative structure of the study and a description of the successful implementation of the accrual phase.
authors.affiliation: Southwest Oncology Group Statistical Center, M/S M3-C102, 1100 Fairview Avenue North, Box 19024, Seattle, WA 98109-1024, USA. pgoodman@fhcrc.org
authors.forename: Phyllis J
authors.initials: PJ
authors.lastname: Goodman
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Tangen
authors.forename: John J
authors.initials: JJ
authors.lastname: Crowley
authors.forename: Susan M
authors.initials: SM
authors.lastname: Carlin
authors.forename: Anne
authors.initials: A
authors.lastname: Ryan
authors.forename: Charles A
authors.initials: CA
authors.lastname: Coltman
authors.forename: Leslie G
authors.initials: LG
authors.lastname: Ford
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
mesh_terms: D018890:Chemoprevention; D042944:Cholestenone 5 alpha-Reductase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D018120:Finasteride / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000453:epidemiology / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D012107:Research Design
chemical_list: D004791:Enzyme Inhibitors; D018120:Finasteride; D042944:Cholestenone 5 alpha-Reductase