Nogo and axon regeneration.
Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the postreceptor components Rho-A and ROCK induce long-distance axonal regeneration and compensatory sprouting, accompanied by an impressive enhancement of functional recovery, in the rat and mouse spinal cord.
Schwab
Martin E
ME
Brain Research Institute University of Zurich, and Department of Biology, Swiss Federal Institute of Technology, Winterthurerstrasse 190, 8057 Zurich, Switzerland. schwab@hifo.unizh.ch
D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D000070798:Nogo Proteins
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; C000603201:Rtn4 protein, mouse; C000603197:Rtn4 protein, rat