Benefits and limitations of testing for resistance to HIV drugs.
Since drug resistance was first described in HIV in 1989, great progress has been made in our understanding of its genetic basis and molecular mechanisms. Despite these advances and the introduction of many new antiretroviral drugs, resistance remains prevalent. The types of drug resistance tests and their relative advantages and disadvantages are reviewed. How and when these tests should be used to inform HIV clinical practice and their place in anti-HIV drug development are considered.
Richman
Douglas D
DD
Veterans Affairs San Diego Healthcare System and University of California San Diego, Departments of Pathology and Medicine, 0679, 9500 Gilman Drive, La Jolla, CA 92093-0679, USA. drichman@ucsd.edu
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use; D024882:Drug Resistance, Viral / Q000187:drug effects / Q000235:genetics*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests
D019380:Anti-HIV Agents