Computational simulation of chronic persistent virus infection: factors determining differences in clinical outcome of HHV-6, HIV-1 and HTLV-1 infections including aplastic, hyperplastic and neoplastic responses.
A computational model was recently designed to simulate cellular changes in the T cell immune system. The model was validated by simulating cell changes in viral infections which target the same CD4+ T cell, yet cause either hyperplastic, aplastic or neoplastic responses. Respective case material for comparison was available from human infections with human herpesvirus-6 (HHV-6), human immunodeficiency virus (HIV-1) or human T cell leukemia virus (HTLV-1). Starting with cell values for a healthy human individual, factorial changes that influence the individual course of the various infections were determined by an algorithm search procedure. Such factorial differences determining a clinical course with aplasia, hyperplasia or neoplasia are outlined and further discussed in this paper.
Krueger
G R F
GR
Department of Internal Medicine, University of Texas-Houston Medical School, Houston, Texas 77030, USA. Gerhard.Krueger@uth.tmc.edu
Brandt
M E
ME
Wang
G
G
Buja
L M
LM
D000465:Algorithms; D002908:Chronic Disease; D003198:Computer Simulation; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D015497:HIV-1; D015490:HTLV-I Infections / Q000276:immunology* / Q000473:pathology; D015654:Herpesvirus 6, Human; D015368:Human T-lymphotropic virus 1; D006801:Humans; D006965:Hyperplasia; D018448:Models, Immunological; D009369:Neoplasms / Q000276:immunology / Q000821:virology*; D019349:Roseolovirus Infections / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology