[Comparative study on angiogenesis effect of Astragalus membranaceus and Angelica sinensis in chick embryo choriollantoic membrane].
OBJECTIVE
To explore the angiogenesis effect of Astragalus membranaceus and Angelica sinensis with different ratio in chick embryo chorioallantoic membrane (CAM).


METHODS
Chicken CAM model was adopted. The rat blood serum containing different ratio of Astragalus membranaceus and Angelica sinensis was put daily into 3-day chick embryo. CAMs and CAM angiogenesis were observed at 72 h after incubation.


RESULTS
Better effects were obtained in the formation of capillary and the count of blood vessel in groups treated by Astragalus memhranaceus and Angelica sinensis in the ratio of five to one, compared with the NS control group and the other ratio groups of Astragalus memhranaceus and Angelica sinensis.


CONCLUSIONS
Astragalus memhranaceus and Angelica sinensis in 5:1 ratio have certain promotive effect on the formation of capillary. The Danggui Buxue Decoction has the best ratio.
Lei
Yan
Y
Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091, China.
Wang
Jun-hui
JH
Chen
Ke-ji
KJ
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D002642:Chick Embryo; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C477279:danggui buxue decoction