Development and function of CD25+CD4+ regulatory T cells.
The essential role played by CD25(+)CD4(+) regulatory T cells (T(R) cells) in the control of physiological as well as pathological immunity is now well established, but many aspects of their biology still remain unclear. One of the unresolved issues regards their development: where does this occur, what signals are required, and how do T(R) cells fit into the larger taxonomy of the T-cell family? Recent data has begun to shed light on the development and function of these important cells.
Fehérvari
Zoltán
Z
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Shogo-in 53, Sakyo-ku, Kyoto 606-8507, Japan.
Sakaguchi
Shimon
S
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology; D051858:Forkhead Transcription Factors; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008954:Models, Biological; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D017634:Self Tolerance / Q000276:immunology; D015398:Signal Transduction; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D004268:DNA-Binding Proteins; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D015375:Receptors, Interleukin-2