title: T cell subpopulations mediating inhibition of feline immunodeficiency virus replication in mucosally infected cats.
abstract: Feline immunodeficiency virus (FIV) infection induces an increase in two subpopulations (CD8alpha(+)beta(low) and CD8alpha(+)beta(-)) within CD8(+) peripheral blood lymphocytes (PBLs) of cats. It is known that depletion of CD8(+) cells often results in augmentation of FIV proliferation in PBL culture, similarly to the case of human immunodeficiency virus. In this study, we attempted to define PBL subpopulations mediating antiviral activity in five cats intravaginally infected with a molecularly cloned FIV isolate. Several subpopulations (CD8alpha(+)beta(+), CD8alpha(+)beta(-), and CD4(+) cells) were shown to participate in inhibition of the FIV replication, at least in part, in a major histocompatibility complex-unrestricted manner. Moreover, the subpopulations showing anti-FIV activity were different among the individual cats.
authors.affiliation: Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shimojima
authors.forename: Yorihiro
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Yukinobu
authors.initials: Y
authors.lastname: Tohya
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Akashi
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002371:Cat Diseases / Q000276:immunology* / Q000821:virology; D002415:Cats; D002460:Cell Line; D016089:Immunodeficiency Virus, Feline / Q000276:immunology* / Q000502:physiology*; D016180:Lentivirus Infections / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D007963:Leukocytes, Mononuclear / Q000276:immunology / Q000821:virology*; D009092:Mucous Membrane / Q000821:virology; D011533:Proviruses / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014779:Virus Replication / Q000276:immunology
chemical_list: D015704:CD4 Antigens; D016827:CD8 Antigens; C433839:CD8alphabeta antigen