[Immunomodulation activity of new vaccines for pertussis prophylaxis--acellular pertussis vaccine and adsorbed DPT vaccine with acellular component].
The immunomodulating activity of acellular pertussis vaccine (APV) and adsorbed DPT vaccine with acellular pertussis component (DPTA vaccine) was studied. The study revealed that only large doses of APV, 10 immunizing doses (ID), suppressed humoral and cell-mediated response to sheep red blood cells (SRBC). 1 ID produced no influence on the formation of antibody producing cells, but increased the development of delayed hypersensitivity (DH) to SRBC. The modulation of cell-mediated immune response, induced by APV, returned to normal after the injection of purified staphylococcal toxoid, used as immunomodulator, in doses of 0.15 BU per mouse and 1.5 BU per mouse. DPTA vaccine containing 1 ID, as well as 10 ID, produced no immunomodulating effect. This was established by the evaluation of humoral response to SRBC in CBA mice and the study of the formation of DH to SRBC in BALB/c mice. As indicated by the total of the presented data, the inclusion of APV into DPTA vaccine enhanced the immunological safety of its pertussis component.
Semenova
I B
IB
Gamaleya Research Institute of Epidemiology and Microbiology, Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Remova
T N
TN
Bazhanova
I G
IG
Britsina
M V
MV
Zakharova
N S
NS
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007111:Immunity, Cellular; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D012756:Sheep; D013208:Staphylococcal Toxoid / Q000008:administration & dosage; D022282:Vaccines, Acellular / Q000008:administration & dosage* / Q000276:immunology; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D013208:Staphylococcal Toxoid; D022282:Vaccines, Acellular