Live birth after ovarian tissue transplant.
Radiation and high-dose chemotherapy may render women with cancer prematurely sterile, a side-effect that would be avoided if ovarian tissue that had been removed before treatment could be made to function afterwards. Live offspring have been produced from transplanted ovarian tissue in mice and sheep but not in monkeys or humans, although sex steroid hormones are still secreted. Here we describe the successful transplantation of fresh ovarian tissue to a different site in a monkey, which has led to the birth of a healthy female after oocyte production, fertilization and transfer to a surrogate mother. The ectopically grafted tissue functions without surgical connection to major blood vessels and sets the stage for the transplantation of cryopreserved ovarian tissue in humans.
Lee
D M
DM
Oregon Health & Science University, Department of Obstetrics and Gynecology, Pediatrics, Physiology and Pharmacology, Oregon National Primate Research Center, Portland, Oregon 97201, USA. leedavi@ohsu.edu
Yeoman
R R
RR
Battaglia
D E
DE
Stouffer
R L
RL
Zelinski-Wooten
M B
MB
Fanton
J W
JW
Wolf
D P
DP
D000818:Animals; D000831:Animals, Newborn; D006063:Chorionic Gonadotropin / Q000097:blood; D015925:Cryopreservation; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D008253:Macaca mulatta / Q000097:blood / Q000502:physiology*; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000502:physiology* / Q000637:transplantation*; D009928:Organ Specificity; D010053:Ovary / Q000166:cytology / Q000502:physiology* / Q000601:surgery / Q000637:transplantation*; D036801:Parturition; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D012098:Reproduction / Q000502:physiology*; D020554:Sperm Injections, Intracytoplasmic
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone