title: Global approach to multichannel electroencephalogram analysis for diagnosis and clinical evaluation in mild Alzheimer's disease.
abstract: To establish an early diagnosis of Alzheimer's disease (AD), we evaluated brain spatial dynamics and cognitive function in mild AD. Seventeen patients with the diagnosis of mild AD and 17 age-matched controls were examined for Omega (global complexity), Sigma (total power) and Phi (generalized frequency) by 19-channel electroencephalography (EEG). As a result, the mild AD group showed significantly higher Omega values than the control group. The Phi values were highly correlated with the Mini-Mental State Examination scores and the full IQ and performance IQ scores of the Japanese Wechsler Adult Intelligence Scale Revised. These results indicate an increase in spatial complexity of the brain electric field in mild AD, as well as a close relationship between slowing of the global frequency of field changes and the cognitive decline in mild AD.
authors.affiliation: Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan. yoshimum@takii.kmu.ac.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Isotani
authors.forename: Takami
authors.initials: T
authors.lastname: Yagyu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Irisawa
authors.forename: Tsunetaka
authors.initials: T
authors.lastname: Yoshida
authors.forename: Masao
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Minami
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Nobuhara
authors.forename: Gaku
authors.initials: G
authors.lastname: Okugawa
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000209:etiology*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology; D007361:Intelligence Tests; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric