[Endothelial dysfunction and risk factors of its development in subjects with family history of atherosclerosis].
Brachial artery blood flow reactions to hyperemia and hyperventilation (endothelium dependent vasodilation and vasoconstriction) were studied by doppler sonography in 60 persons aged 19-39 years with family history of atherosclerosis and risk factors of this disease. Reactivity of peripheral artery and risk factors of atherosclerosis development were found to be interrelated. The results allowed to suggest participation of atherogenic fractions of lipoproteins, triglycerides, proinflammatory cytokines, and monocyte derived NO in formation of pathological vascular reactions in persons with family history of atherosclerosis.
Kovalev
I A
IA
Research Institute for Cardiology of the Research Centre of RAMN Siberian Branch, ul. Kievskaya 111, 634012 Tomsk, Russia.
Martsinkevich
G I
GI
Suslova
T E
TE
Sokolov
A A
AA
D000328:Adult; D003324:Coronary Artery Disease / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000235:genetics; D007375:Interleukin-1 / Q000276:immunology; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology; D018608:Ultrasonography, Doppler
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha