[The effects of banxia houpu decoction on a chronic mild stress model of depression].
OBJECTIVE
To study the effect of Banxia Houpu Decoction on a chronic mild stress model of depression and investigate the antidepressive mechanism.


METHODS
With consumption of a 1% sucrose solution as an index, and by subjecting rats to a variety of mild stressors for a prolonged period of time, a chronic mild stress model was developed. The levels of the blood lipid were measured by blood lipid kits, the natural kill (NK) cell activity in the spleen was measured with the method of the enzyme lactate dehydrogenase (LDH) released, the superoxide dismutase (SOD) activity in red blood cell was assayed by the Autoxidation of Pyrogallol method, the NO synthase (NOS) activity in serum and tissue was measured by NOS kits, and the content of malondialdehyde(MDA) was measured by MDA kits.


RESULTS
Banxia Houpu Decoction significantly increased the consumption of sucrose solution, increased the level of the high density lipoprotein (HDL-C), decreased the level of the Triglyceride(TG) in serum, enhanced the activity of the NK in spleen, decreased the activity of the SOD in red blood and the activity of the NOS in serum and tissue, and reduced the content of MDA in tissue by effect on lipid Peroxidation in CNS model of depression.


CONCLUSIONS
Banxia Houpu Decoction has antidepressant effect in different ways.
Li
Jina-mei
JM
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China.
Yang
Cheng
C
Zhang
Wei-yun
WY
Kong
Ling-dong
LD
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000276:immunology / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000150:complications; D013395:Sucrose / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D000928:Antidepressive Agents; C120141:Banxia Houpo Tang; D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D008315:Malondialdehyde; D013395:Sucrose; D013482:Superoxide Dismutase