The efficacy of divalproex for partial epilepsies.
Valproic acid has clear efficacy in the treatment of partial epilepsies. Its multiple mechanisms predicted its broad spectrum of efficacy and preclinical experimental data prompted its clinical use. Valproic acid's efficacy has been repeatedly demonstrated in clinical trials over the past 25 years. Its efficacy in the treatment of partial epilepsies is similar or better than both the traditional and new antiepileptic drugs. Its side effect profile is well known and manageable, especially with extended-release formulations.
Smith
Michael C
MC
Rush Institute, University of Chicago, 1653 West Congress Parkway, Chicago, IL 60612, USA. michael_c_smith@rush.edu
D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004342:Drug Hypersensitivity; D004828:Epilepsies, Partial / Q000188:drug therapy*; D006801:Humans; D014635:Valproic Acid / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D000927:Anticonvulsants; D014635:Valproic Acid