[Recurrent polyomavirus infections in kidney transplants (BK virus nephropathy)].
BK-virus nephropathy was recently recognised as a new complication that affects renal allografts and causes dysfunction. We report a case of a recipient of simultaneous kidney-pancreas allografts. Fourteen months after the transplant, the renal allograft became dysfunctional with elevation of serum creatinine level. The diagnosis of BK-virus nephropathy was established by needle renal biopsy with immunohistochemical detection of human polyoma virus. Immunosuppressive therapy was reduced but progressive dysfunction developed and the patient had to undergo a renal retransplantation 11 months after the diagnosis of the infection. Due to repeated renal dysfunction, needle biopsy was performed, and the diagnosis of repeated BK-virus nephropathy was established six months after the retransplantation. The pancreas allograft has functioned well for the entire period.
Honsová
E
E
Pracovistĕ klinické a transplantacní patologie, IKEM, Praha. eva.honsova@medicon.cz
Lodererová
A
A
Havrdová
T
T
Voska
L
L
Boucek
P
P
D000328:Adult; D001739:BK Virus; D001707:Biopsy, Needle; D006801:Humans; D016867:Immunocompromised Host; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000175:diagnosis* / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D027601:Polyomavirus Infections / Q000175:diagnosis* / Q000473:pathology; D012008:Recurrence; D012086:Reoperation; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000473:pathology