title: [Study of cerebral protective effects of naosaitong in animals].
abstract: OBJECTIVE
  To investigate the influence of Naosaitong (NST) on the cerebral blood flow (CBF), the infarct areas and blood rheology in animals.
  
  
  METHODS
  NST's cerebral protective effects were investigated by using middle cerebral artery occlusion (MCAO), bilateral common carotid artery ligation, and carrogeenin-induced thrombus model rats, being administrated with medicine for seven days.
  
  
  RESULTS
  Three dosage groups of NST increased CBF in anesthetized rabbits, reduced the infarct areas in MCAO rats, decreased the physical sign indexes, and water quantities. They increased the activities of Glutathione peroxidase (GPX) and Catalase (CAT), decreased the contractions of Lipid peroxidase (LPO) and Lactate (LD) in the cerebral ischemia-reperfusion rats; shortened the length of thrombus and improved the blood rheology in the carrogeenin-induced thrombus model rats, and prolonged hypoxia-resisting time in mice.
  
  
  CONCLUSIONS
  NST can evidently increase CBF in rabbits, improve the cerebral edema brain tissues' injure and nervous physical sign indexes in the cerebral ischemia-reperfusion rats, reduce the infarct areas in MCAO rats, postpone thrombosis course and have antioxidation effects, which show that NST can obviously protect the brain tissues in the experimental cerebral infarct model rats.
authors.affiliation: Beijing University of Traditional Chinese Medicine, Beijing 100102, China.
authors.forename: Yu-jie
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Xing-li
authors.initials: XL
authors.lastname: Yan
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology*; D007865:Leeches / Q000737:chemistry; D030004:Ligusticum / Q000737:chemistry; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D012212:Rheology / Q000187:drug effects; D012250:Rheum / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D018696:Neuroprotective Agents