Ovarian neoplasms in patients with colorectal cancer: understanding the role of prophylactic oophorectomy.
Although the role of prophylactic oophorectomy is currently under debate and not well defined, it is of increasing and considerable relevance, especially in premenopausal women, particularly those with identifiable hereditary cancer syndromes. Patients with colorectal cancer with ovarian metastases are often symptomatic, require surgery, and have poor survival. Prophylactic oophorectomy abolishes the increased risk of primary ovarian cancer in these patients, resects synchronous metastases, and prevents development of metachronous ovarian metastases. Prophylactic oophorectomy trials, mostly conducted in postmenopausal women, have not shown survival advantage. In patients with ovarian metastases of colorectal cancer, maximal cytoreductive surgery followed by adjuvant therapy employing newer chemotherapeutic agents, whole abdominal irradiation with chemosensitization, or hyperthermic intraperitoneal chemotherapy may improve outcomes in selected patients.
Hanna
Nader N
NN
Department of Surgery, Surgical Oncology Service, Markey Cancer Center, University of Kentucky, Lexington, USA. nhanna1@uky.edu
Cohen
Alfred M
AM
D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000556:secondary / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods*; D016019:Survival Analysis
D004967:Estrogens