title: Role of nitric oxide in tumor angiogenesis.
abstract: Nitric oxide (NO) is an important signalling molecule that acts in many tissues to regulate different physiological and pathological processes. We have contributed to demonstrate that NO stimulates angiogenesis and mediates the effect of different angiogenic molecules. In human tumors NOS expression and activity correlate with tumor growth and aggressiveness, through angiogenesis stimulation and regulation of angiogenic factor expression. Drugs affecting the NOS pathway appear promising antitumor strategies by reducing edema, inhibiting angiogenesis and facilitating the delivery of chemotherapeutical agents.
authors.affiliation: Section of Pharmacology, Dept. Molecular Biology and C.R.I.S.M.A., University of Siena Pharmacy School, Via A. Moro 2, 53100 Siena, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Morbidelli
authors.forename: Sandra
authors.initials: S
authors.lastname: Donnini
authors.forename: Marina
authors.initials: M
authors.lastname: Ziche
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000473:pathology; D009389:Neovascularization, Pathologic; D009569:Nitric Oxide; D020033:Protein Isoforms
chemical_list: D020033:Protein Isoforms; D009569:Nitric Oxide