Fatty acid alterations in liver and milk of cadmium exposed rats and in brain of their suckling offspring.
Fatty acid composition was studied in milk at day 14 and in liver at day 24 after parturition of lactating rats exposed to 0 ppm, 5 ppm or 25 ppm cadmium (Cd) via drinking water for 17 days during lactation, and in the brain of their offspring at day 19 after birth. In the liver phospholipid fraction, 22:5(n-3) was significantly higher, while in the triacylglycerol fraction 22:6(n-3)/20:5(n-3) ratio was significantly lower in the 25 ppm group compared to the controls. Significantly higher proportions of 16:0 and lower proportions of medium-chain fatty acids, 8:0-14:0, were observed in milk of dams in the 25 ppm group, indicating decreased enzymatic activity of thiotransferase II in the mammary gland. Slightly increased levels of 20:3(n-6) were observed in brains of pups in the 25 ppm group compared to control. The results indicate that Cd exposure influences fatty acid metabolism in lactating rats.
Grawé
Kierstin Petersson
KP
Department of Food Science, Swedish University of Agricultural Sciences, Box 7051, SE-750 07 Uppsala, Sweden. kipe@slv.se
Pickova
Jana
J
Dutta
Paresh Chandra
PC
Oskarsson
Agneta
A
D000818:Animals; D000831:Animals, Newborn; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D005260:Female; D007774:Lactation; D008099:Liver / Q000737:chemistry; D008321:Mammary Glands, Animal / Q000201:enzymology; D008892:Milk / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D005227:Fatty Acids; D002104:Cadmium