Watch thy neighbor: cancer is a communal affair.
Malignant transformation of an epithelium occurs within the context of a dynamically evolving tissue stroma that is composed of multiple cell types surrounded by an extracellular matrix. Because stromal-epithelial interactions regulate tissue homeostasis and can profoundly influence tumorigenesis it has been proposed that the stromal microenvironment is an epigenetic tumor modifier that can either positively or negatively regulate the malignant behavior of genetically aberrant cells. New work reported in this issue of Journal of Cell Science now provides compelling evidence that alterations in the stroma are necessary and also sufficient for induction of malignant behavior by genetically normal cells.
Weaver
Valerie M
VM
Department of Pathology and Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA. vmweaver@mail.med.upenn.edu
Gilbert
Penney
P
D000477:Alkylating Agents; D000818:Animals; D002273:Carcinogens; D002454:Cell Differentiation; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology* / Q000637:transplantation*; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D011905:Genes, ras; D008325:Mammary Neoplasms, Experimental / Q000209:etiology*; D008770:Methylnitrosourea; D009154:Mutation; D009368:Neoplasm Transplantation; D051381:Rats; D011920:Rats, Inbred WF; D017154:Stromal Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D000477:Alkylating Agents; D002273:Carcinogens; D008770:Methylnitrosourea