title: Kringle 5 peptide-albumin conjugates with anti-migratory activity.
abstract: Three peptide fragments of the kringle 5 region of plasminogen and their respective N- and C-terminus maleimido derivatives conjugated to Cys34 of human serum albumin were evaluated in vitro using a human umbilical vein endothelial cell (HUVEC) migration assay and a human plasma stability assay. The N-terminus maleimido derivative of the 64 to 74 segment of kringle 5 conjugated to human serum albumin possessed remarkable anti-migratory activity.
authors.affiliation: Research Department, ConjuChem Inc., 225 President-Kennedy Ave., Suite 3950, Montréal, QC, H2X 3Y8 Canada. leger@conjuchem.com
authors.forename: Roger
authors.initials: R
authors.lastname: Léger
authors.forename: Corinne
authors.initials: C
authors.lastname: Benquet
authors.forename: Xicai
authors.initials: X
authors.lastname: Huang
authors.forename: Omar
authors.initials: O
authors.lastname: Quraishi
authors.forename: Pieter
authors.initials: P
authors.lastname: van Wyk
authors.forename: Dominique
authors.initials: D
authors.lastname: Bridon
mesh_terms: D000595:Amino Acid Sequence; D002465:Cell Movement / Q000187:drug effects*; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D018082:Kringles; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology*; D010958:Plasminogen / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology; D012709:Serum Albumin / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D010446:Peptide Fragments; D012709:Serum Albumin; D010958:Plasminogen