Recent advances in the genetics of attention deficit hyperactivity disorder.
In the past few years, interest in the molecular genetics of attention deficit hyperactivity disorder (ADHD) has grown enormously, with many groups searching for susceptibility genes, often through large collaborative efforts facilitated by the International ADHD Genetics Consortium. Association findings for several candidate genes within the dopaminergic system, the DRD4 and DRD5 receptor genes and the dopamine transporter gene, DAT1, have been well replicated, and the first of several ongoing genome linkage scan study results have been published. Current challenges in this field are to identify the actual functional variant(s) in these genes conferring susceptibility and other genetic and environmental risk factors for ADHD.
Kent
Lindsey
L
Developmental Psychiatry Section, University of Cambridge, Douglas House, Cambridge CB2 2AH, UK. lk255@cam.ac.uk
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D050483:Dopamine Plasma Membrane Transport Proteins; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000235:genetics*; D008967:Molecular Biology / Q000639:trends; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010597:Pharmacogenetics / Q000639:trends; D010641:Phenotype; D011954:Receptors, Dopamine / Q000235:genetics*; D012307:Risk Factors
D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011954:Receptors, Dopamine; C493214:SLC6A3 protein, human