[The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats].
OBJECTIVE
To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action.


METHODS
Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI).


RESULTS
Seed oil of Hippophae rhamnides 0.7 and 0.35 g.kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats.


CONCLUSIONS
These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.
Cheng
Ti-juan
TJ
Lanzhou Medical College, Lanzhou 730000, Ganshu, China. litjian@public.lz.gs.cn
Wang
Yu-bin
YB
Gao
Li-ping
LP
Sun
Yi-fang
YF
Zhang
Jian
J
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D031281:Hippophae / Q000737:chemistry; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D010938:Plant Oils