[Protective effect of hydrophilic ubiquinone on cardiac muscle during oxidative stress].
OBJECTIVE
To assess effects of long term administration of a natural antioxidant ubiquinone on isoproterenol induced myocardial injury.


METHODS
Rats were given hydrophilic ubiquinone with water for 8 weeks.


RESULTS
Long term use of ubiquinone did not affect myocardial ultrastructure and relative myocardial weight. The dose of isoproterenol used in this study exerted moderate damaging action evidenced by disappearance of glycogen from sarcoplasm, development of edema, and partial destruction of mitochondrial cristae. These effects were associated with lowering of maximal magnitude of contractile function of the isolated heart and augmentation of superoxide radicals release in perfusate. These changes (except disappearance of glycogen) were not present in hearts of ubiquinone fed rats. Compared with controls mitochondria isolated from hearts of ubiquinone fed rats had higher respiratory control and more than twice lower rate of superoxide generation.


CONCLUSIONS
As damaging effects of isoproterenol are mediated by augmented generation of active forms of oxygen the results obtained allow to suggest that myocardium of ubiquinone fed animals is characterized by elevated power of the antioxidant system.
Lakomkin
V L
VL
Russian Cardiology Research Complex, ul. Tretiya Cherepkovskaya 15a, 121552 Moscow, Russia.
Korkina
O V
OV
Tsyplenkova
V G
VG
Timoshin
A A
AA
Ruuge
E K
EK
Kapel'ko
V I
VI
D000818:Animals; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009206:Myocardium; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*
D014451:Ubiquinone; C003741:ubiquinol