Retinal pattern and the genetic basis of its formation in zebrafish.
The vertebrate nervous system contains an immense diversity of distinct cellular components that are organized into precise spatial patterns. The importance of accurate neuronal architecture is particularly obvious in the retina, where it is necessary for the formation of visual images. The retina is structured in a distinct layered pattern that is remarkably conserved in evolution, including phyla as diverse as primates and teleost fish. Genetic analysis in zebrafish reveals mechanisms that are essential for the formation of this architecture.
Pujic
Zac
Z
Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02110, USA. zac_pujic@meei.harvard.edu
Malicki
Jarema
J
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D005123:Eye / Q000033:anatomy & histology / Q000166:cytology / Q000196:embryology; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D007527:Isoenzymes; D008954:Models, Biological; D009154:Mutation; D009474:Neurons / Q000166:cytology / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D012160:Retina / Q000033:anatomy & histology / Q000166:cytology / Q000196:embryology*; D015534:Trans-Activators / Q000502:physiology; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics / Q000502:physiology; D000099293:Protein Kinase C-lambda
D053823:Hedgehog Proteins; D007527:Isoenzymes; D011493:Protein Kinase C; D015534:Trans-Activators; D000099293:Protein Kinase C-lambda