Exploring the phosphoproteome with mass spectrometry.
Protein phosphorylation is a reversible post-translational modification crucial in the control of numerous regulatory pathways. Understanding the highly interconnected nature of such networks requires new broader-scale analysis techniques. This report summarizes recent advances in the use of mass spectrometry to assess phosphorylation events in ever more complex systems.
Peters
Eric C
EC
Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA. epeters@gnf.org
Brock
Ansgar
A
Ficarro
Scott B
SB
D000818:Animals; D006801:Humans; D013058:Mass Spectrometry; D010750:Phosphoproteins / Q000032:analysis*; D010766:Phosphorylation; D020543:Proteome / Q000032:analysis* / Q000737:chemistry; D015398:Signal Transduction
D010750:Phosphoproteins; D020543:Proteome