Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.
Fan
Wei
W
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239-3098, USA. fanw@ohsu.edu
Ellacott
Kate L J
KL
Halatchev
Ilia G
IG
Takahashi
Kanji
K
Yu
Pinxuan
P
Cone
Roger D
RD
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000166:cytology / Q000378:metabolism; D015536:Down-Regulation; D004435:Eating / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D009434:Neural Pathways / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011333:Pro-Opiomelanocortin / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044105:Receptor, Melanocortin, Type 4 / Q000172:deficiency / Q000378:metabolism*; D012528:Satiety Response / Q000502:physiology*; D012844:Sincalide / Q000031:analogs & derivatives* / Q000502:physiology*; D017552:Solitary Nucleus / Q000166:cytology / Q000378:metabolism*
C090019:8-sulfocholecystokinin octapeptide; D016760:Proto-Oncogene Proteins c-fos; D044105:Receptor, Melanocortin, Type 4; D011333:Pro-Opiomelanocortin; D012844:Sincalide