title: [Early postdenervation depolarization: effect of NO, acetylcholine and glutamates on chloride transporter and a general view of nerve functions].
abstract: The survey of the original papers by Vyskocil and his co-workers draws attention to their contribution not only to the classic theory of neuromuscular transmission, but it discusses them especially in relation to some general principles of nervous functions. The mechanisms of synaptic plasticity, co-localization of various types of receptors in a single synapse, as well as practical therapeutic implications could serve as examples. The regulatory functions connected with NO synthase and calcineurin are then discussed in a broader context.
authors.affiliation: Vojenská lékarská akademie J. E. Purkynĕ, Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Herink
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D019703:Calcineurin / Q000502:physiology; D002712:Chlorides / Q000378:metabolism*; D004594:Electrophysiology; D018698:Glutamic Acid / Q000494:pharmacology*; D006801:Humans; D017136:Ion Transport; D009045:Motor Endplate / Q000378:metabolism / Q000502:physiology; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation; D009469:Neuromuscular Junction; D009569:Nitric Oxide / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D002712:Chlorides; D009569:Nitric Oxide; D018698:Glutamic Acid; D019703:Calcineurin; D000109:Acetylcholine