title: Calcifying obstructive pancreatitis: a study of intraductal papillary mucinous neoplasm associated with pancreatic calcification.
abstract: OBJECTIVE
  We have observed intraductal papillary mucinous neoplasm (IPMN) associated with pancreatic calcification. The aim of this study is to describe the profile of IPMN associated with calcification and gain insights into the pathogenesis of calcification in IPMN.
  
  
  METHODS
  We identified 10 patients with IPMN with pancreatic calcification, of whom 7 underwent pancreatic resection. We reviewed demographic data, history of previous pancreatitis, and radiological and histological features of these patients.
  
  
  RESULTS
  In patients with IPMN with calcification (mean age, 65 +/- 12 yr; 50% men), a diagnosis of chronic calcifying pancreatitis was entertained in 5 of 10 patients; 2 patients had undergone previous endoscopic therapy for stone removal. There was no previous history of pancreatitis in 9 of 10 patients. Radiologically, calcifications were seen diffusely throughout the gland in 8 of 10 patients and interpreted as chronic calcific pancreatitis. Although 1 of the 7 patients who underwent resection had diffuse IPMN throughout the gland, 6 patients had IPMN confined to the head or uncinate process (mean size, 2.75 cm; range, 1.1-5 cm). Histologically, 6 of 7 IPMNs were adenomas, and 1 patient had invasive cancer. No patient had intratumoral calcification. All 7 patients had calcification within the main pancreatic duct and/or side branches, often within inspissated mucus.
  
  
  CONCLUSIONS
  IPMN associated with pancreatic calcification can lead to misdiagnosis and inappropriate treatment for chronic calcifying pancreatitis. In the absence of intratumoral calcification or a previous history of long-standing chronic pancreatitis, calcification in IPMN likely represents a unique and hitherto unrecognized form of calcifying obstructive pancreatitis caused by prolonged partial obstruction of the pancreatic duct.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, Minnesota 55905, USA.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Zapiach
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Yadav
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Smyrk
authors.forename: Joel G
authors.initials: JG
authors.lastname: Fletcher
authors.forename: Randall K
authors.initials: RK
authors.lastname: Pearson
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Clain
authors.forename: Michael B
authors.initials: MB
authors.lastname: Farnell
authors.forename: Suresh T
authors.initials: ST
authors.lastname: Chari
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002908:Chronic Disease; D016145:Endoscopy, Digestive System; D010188:Exocrine Pancreatic Insufficiency / Q000175:diagnosis / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010183:Pancreatic Ducts / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010195:Pancreatitis / Q000145:classification* / Q000175:diagnosis / Q000601:surgery; D019512:Pancreatitis, Alcoholic / Q000145:classification / Q000175:diagnosis / Q000473:pathology; D018300:Papilloma, Intraductal / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed