Poly(vinyl alcohol) and poly(vinyl pyrrolidone) blended films for local nitric oxide release.
The nitric oxide (NO) donor S-nitrosoglutathione (GSNO) was incorporated in solid polymeric films of poly(vinyl alcohol) (PVA), poly(vinyl pyrrolidone) (PVP) and blended PVA/PVP. These matrices were found to provide a great stabilization effect on the thermal decomposition of GSNO, leading to 8-16-fold reduction in the first-order rate constants of NO release, compared to aqueous GSNO solutions. PVA/PVP-GSNO released 90% of the NO supply, over a time period of 24h at 37 degrees C. Differential scanning calorimetry has confirmed the miscibility between the two polymeric components. Stress-strain analysis has shown an improvement of the mechanical property of PVA films in the PVA/PVP blend, which leads to an increase of 25% in the stress at break. Scanning electron microscopy has shown that the PVA/PVP-GSNO blend leads to a smooth coating of metallic surfaces. These properties, allied to the already known good biocompatibility of PVA and PVP, makes GSNO-containing PVA and PVA/PVP blend films good candidates for the local and controlled release of NO in target areas.
Seabra
Amedea Barozzi
AB
Instituto de Quimica, Universidade Estadual de Campinas, UNICAMP, Caixa Postal 6154, 13084-971 Campinas, SP, Brazil.
De Oliveira
Marcelo Ganzarolli
MG
D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D004548:Elasticity; D007700:Kinetics; D008422:Materials Testing; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry*; D011205:Povidone / Q000031:analogs & derivatives* / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature; D013718:Tensile Strength
D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C050762:poly(vinyl alcohol-co-N-vinyl-2-pyrrolidone); D009569:Nitric Oxide; D011142:Polyvinyl Alcohol; D011205:Povidone