title: Left ventricular thrombosis is associated with increased mean platelet volume in patients with dilated cardiomyopathy and sinus rhythm.
abstract: OBJECTIVE
  Dilated cardiomyopathy has been associated with left ventricular thrombosis, which leads to substantial morbidity and mortality as a site for peripheral emboli. There are some studies on patients with dilated cardiomyopathy showing altered haemostasis and platelet behaviour despite sinus rhythm. Mean platelet volume, which is the most accurate and simple estimate of platelet reactivity, may be associated with the development of left ventricular thrombosis.
  
  
  RESULTS
  We prospectively enrolled 48 consecutive patients with dilated cardiomyopathy and sinus rhythm with left ventricular thrombosis and compared them with an age-sex-matched control group having dilated cardiomyopathy without left ventricular thrombosis. We found that in patients with left ventricular thrombosis mean platelet volume is significantly higher than those without (9.5 +/- 0.8 vs. 8.7 +/- 0.6, p < 0.001).
  
  
  CONCLUSIONS
  Mean platelet volume is increased in patients with dilated cardiomyopathy and sinus rhythm having left ventricular thrombosis. This might be reflecting a causal relationship, which in turn requires further study to establish the role of antiplatelet agents both in prevention and in treatment.
authors.affiliation: Yuksek Ihtisas Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey. cardioceptor@ttnet.net.tr
authors.forename: Mehmet Birhan
authors.initials: MB
authors.lastname: Yilmaz
authors.forename: Yesim
authors.initials: Y
authors.lastname: Akin
authors.forename: Senay Funda
authors.initials: SF
authors.lastname: Biyikoglu
authors.forename: Umit
authors.initials: U
authors.lastname: Guray
authors.forename: Halil L
authors.initials: HL
authors.lastname: Kisacik
authors.forename: Sule
authors.initials: S
authors.lastname: Korkmaz
mesh_terms: D001146:Arrhythmia, Sinus / Q000150:complications*; D001792:Blood Platelets / Q000378:metabolism*; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D016022:Case-Control Studies; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000097:blood; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D013927:Thrombosis / Q000097:blood* / Q000150:complications