Cytotoxic activity of five compounds isolated from Colombian plants.
Cytotoxic effect of five known compounds, khellin, berberine, lupeol, scopolin, rapanone, obtained from Colombian plants, were determined against human tumor cell lines as an indicator of the potential anticancer activity of these compounds. Berberine and rapanone presented interesting cytotoxicity.
Cordero
C P
CP
Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Edificio 450, Ciudad Universitaria, Carrera 30-Calle 45, Bogotá D.C., Colombia.
Gómez-González
S
S
León-Acosta
C J
CJ
Morantes-Medina
S J
SJ
Aristizabal
F A
FA
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016227:Benzoquinones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001599:Berberine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D003105:Colombia; D005638:Fruit; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D008519:Medicine, Traditional; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D012639:Seeds
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D010936:Plant Extracts; D001599:Berberine; C054611:rapanone