title: Structural identification and characterization of impurities in moxifloxacin.
abstract: In the synthesis of Moxifloxacin four prominent impurities were detected in HPLC analysis. These impurities were detected in gradient HPLC method. They were isolated from enriched mother liquors and were characterized as 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(S,S)-N-methyl-2,8-diazabicyclo (4,3,0) non-8yl]-4-oxo-3-quinoline carboxylic acid (Impurity-1), methyl-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(S,S)-2,8-diazabicyclo(4,3,0)non-8-yl]-4-oxo-3-quinoline carboxylate (impurity-2), and 1-cyclopropyl-6-fluoro-1,4 dihydro-8-hydroxy-7-[(S,S)-2,8-diazobicyclo(4,3,0)non-8-yl]-4-oxo-3-quinoline carboxylicacid (impurity-3), 1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4 dihydro-3-quinoline carboxylicacid (impurity-4) by means of 1H, 13C NMR, DEPT, IR and mass spectral data. Structural elucidation by spectral data was discussed.
authors.affiliation: Dr. Reddy's Laboratories Ltd., Bulk Actives Unit-III, IDA-Bollaram, Hyderabad, 502325 AP, India.
authors.forename: Y Ravindra
authors.initials: YR
authors.lastname: Kumar
authors.forename: V V N K V
authors.initials: VV
authors.lastname: Prasad Raju
authors.forename: R Rajesh
authors.initials: RR
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Eswaraiah
authors.forename: K
authors.initials: K
authors.lastname: Mukkanti
authors.forename: M V
authors.initials: MV
authors.lastname: Suryanarayana
authors.forename: M Satyanarayana
authors.initials: MS
authors.lastname: Reddy
mesh_terms: D001372:Aza Compounds / Q000032:analysis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D024841:Fluoroquinolones; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D000077266:Moxifloxacin; D011804:Quinolines / Q000032:analysis* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin