Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists.
Low molecular weight amide derivatives were synthesized and evaluated as M(2) receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M(2) receptor antagonists with structural features different from our clinical candidate 1.
Palani
Anandan
A
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. anandan.palani@spcorp.com
Dugar
Sundeep
S
Clader
John W
JW
Greenlee
William J
WJ
Ruperto
Vilma
V
Duffy
Ruth A
RA
Lachowicz
Jean E
JE
D000577:Amides / Q000138:chemical synthesis*; D006801:Humans; D018727:Muscarinic Antagonists / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D043585:Receptor, Muscarinic M2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D000577:Amides; D018727:Muscarinic Antagonists; D043585:Receptor, Muscarinic M2