title: Paeciloxazine, a novel nematicidal antibiotic from Paecilomyces sp.
abstract: A novel nematicidal antibiotic, paeciloxazine has been isolated from the culture broth of a fungus Paecilomyces BAUA3058 strain. This compound, whose structure was determined by spectroscopic methods, has a pyrrolobenzoxazine skeleton. Paeciloxazine has moderate cidal activity against Rhabditis pseudoelongata and is weakly active against some insects.
authors.affiliation: Research Laboratory Agrochemical & Animal Health Products Department, Kaken Pharmaceutical CO., LTD., 301 Gensuke, Fujieda, Shizuoka 426-8646, Japan. kanai-yoshinori@kaken.co.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kanai
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Fujimaki
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Kochi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Konno
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Tokumasu
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003465:Culex; D005285:Fermentation; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010143:Paecilomyces / Q000737:chemistry* / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017172:Rhabditoidea; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000969:Antinematodal Agents; D007306:Insecticides; D007783:Lactones; D010078:Oxazines; D011758:Pyrroles; C483751:paeciloxazine