title: [Influence of blood supply of the esophageal and gastric stumps on anastomotic healing after esophagogastrostomy in rabbits].
abstract: OBJECTIVE
  To study how blood supply of the esophageal and gastric stumps influences the anastomotic healing after esophagogastrostomy in rabbits.
  
  
  METHODS
  Twenty-seven New Zealand rabbits were randomly divided into 3 groups to receive esophagogastrostomy, followed by different procedures. Except for those in group I, all the rabbits were subjected to procedures of reducing the blood supply either of the esophageal or the gastric stump (group II and group III, respectively), followed by single-layer esophagogastric anastomoses using interrupted 5-0 polypropylene sutures. Ten days after operation, all the rats were killed and the anastomotic sites excised for measurement of the inner diameter, tensile strength, and hydroxyproline concentration.
  
  
  RESULTS
  Healing of the esophagograstric anastomosis was obtained in all the rabbits but one with anastomotic leakage in group I and one with perforation of the gastric fundus in group III. The anastomotic inner diameters were similar in all the three groups, whereas the tensile strength and hydroxyproline concentration at the anastomoses decreased in group III in comparison with the other two groups (P<0.05) that had similar measurements (P>0.05).
  
  
  CONCLUSIONS
  Extended length of the free esophageal stump does not significantly affect anastomotic healing as decrease of blood supply in the gastric stump.
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Yi-dong
authors.initials: YD
authors.lastname: Huang
authors.forename: Ke-luo
authors.initials: KL
authors.lastname: Cheng
authors.forename: Xiao-bi
authors.initials: XB
authors.lastname: Cai
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wu
authors.forename: Jian-dong
authors.initials: JD
authors.lastname: Zhan
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D004947:Esophagus / Q000098:blood supply* / Q000601:surgery*; D005260:Female; D018530:Gastric Stump / Q000098:blood supply*; D005774:Gastrostomy; D008297:Male; D011817:Rabbits; D014945:Wound Healing