title: Efficacy of chloroquine, amodiaquine, sulphadoxine-pyrimethamine and combination therapy with artesunate in Mozambican children with non-complicated malaria.
abstract: This paper reports a two-phase study in Manhiça district, Mozambique: first we assessed the clinical efficacy and parasitological response of Plasmodium falciparum to chloroquine (CQ), sulphadoxine-pyrimethamine (SP) and amodiaquine (AQ), then we tested the safety and efficacy in the treatment of uncomplicated malaria, of three combinations: AQ + SP, artesunate (AR) + SP and AQ + AR. Based on the WHO (1996, WHO/MAL/96.1077) in vivo protocol, we conducted two open, randomized, clinical trials. Children aged 6-59 months with axillary body temperature > or = 37.5 degrees C and non-complicated malaria were randomly allocated to treatment groups and followed up for 21 days (first and second trial) and 28 days (first trial). The therapeutic efficacy of AQ (91.6%) was better than that of SP (82.7%) and CQ (47.1%). After 14 days, 69% of the strains were parasitologically resistant to CQ, 21.4% to SP and 26% to AQ. Co-administration of AQ + SP, AR + SP and AQ + AR was safe and had 100% clinical efficacy at 14-day follow-up. The combination therapies affected rapid fever clearance time and reduced the incidence of gametocytaemia during follow-up.
authors.affiliation: Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique. fabacassamo@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Abacassamo
authors.forename: S
authors.initials: S
authors.lastname: Enosse
authors.forename: J J
authors.initials: JJ
authors.lastname: Aponte
authors.forename: F X
authors.initials: FX
authors.lastname: Gómez-Olivé
authors.forename: L
authors.initials: L
authors.lastname: Quintó
authors.forename: S
authors.initials: S
authors.lastname: Mabunda
authors.forename: A
authors.initials: A
authors.lastname: Barreto
authors.forename: P
authors.initials: P
authors.lastname: Magnussen
authors.forename: A M
authors.initials: AM
authors.lastname: Rønn
authors.forename: R
authors.initials: R
authors.lastname: Thompson
authors.forename: P L
authors.initials: PL
authors.lastname: Alonso
mesh_terms: D000655:Amodiaquine / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000009:adverse effects; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage* / Q000009:adverse effects; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D009073:Mozambique; D010963:Plasmodium falciparum / Q000187:drug effects; D011739:Pyrimethamine / Q000008:administration & dosage* / Q000009:adverse effects; D013413:Sulfadoxine / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; D000655:Amodiaquine; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine