title: Synergistic effects of C-peptide and insulin on coronary flow in early diabetic rats.
abstract: The aims of the present study are (1) to examine whether coronary flow is increased and (2) to examine the role of C-peptide in relation to nitric oxide (NO) production and coronary flow in a rat heart (Wistar) during the early stages of type 1 diabetes. Coronary flow increased by 36.4% +/-10.6% (P <.05) during the early stages of streptozotocin-induced diabetes of isolated perfused rat hearts, but NO production increased without significance. C-peptide alone did not change coronary flow, but increased NO production in diabetes. In the presence of insulin, C-peptide reversed both flow and NO production to the control level of normal rats (P <.05). In conclusion, during the early stages of type 1 diabetes, coronary flow was increased, and C-peptide in the presence of insulin synergistically normalized the excessive flow and NO production induced by C-peptide to the control level of normal rats.
authors.affiliation: Department of Medical Engineering, Kawasaki Medical School, Okayama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakane
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Yoshida
authors.forename: Seiichi
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ogasawara
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kajiya
mesh_terms: D000818:Animals; D002096:C-Peptide / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D009569:Nitric Oxide