title: Sentinel node detection in Barrett's and cardia cancer.
abstract: Because of surveillance strategies in patients with known Barrett's esophagus, more patients with high-grade dysplasia or early cancer in the distal esophagus and at the esophagogastric junction are identified. The need for and extent of lymphadenectomy in such patients are controversial. The technique of sentinel lymph node dissection (SLND) to diagnose early lymphatic spread is applied increasingly in tumors of the gastrointestinal tract. The poorly defined lymphatic drainage of the esophagogastric junction has so far prevented many investigators from performing SLND in tumors of this anatomic region. We report the first results of SLND in Barrett's and cardia cancer. The preliminary experience indicates that the method is, even in this anatomical area, feasible and yields good results in early tumors. In advanced tumors, the method lacks sensitivity. Mapping should be done with blue dye and a radiocolloid. The concept of sentinel lymph node mapping and detection thus may open the door to individualized therapy for patients with high-grade dysplasia in a Barrett's esophagus or with early Barrett's and cardia cancer.
authors.affiliation: Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. burian@nt1.chir.med.tu-muenchen.de
authors.forename: Maria
authors.initials: M
authors.lastname: Burian
authors.forename: Hubert J
authors.initials: HJ
authors.lastname: Stein
authors.forename: Andreas
authors.initials: A
authors.lastname: Sendler
authors.forename: Morand
authors.initials: M
authors.lastname: Piert
authors.forename: Jörg
authors.initials: J
authors.lastname: Nährig
authors.forename: Marcus
authors.initials: M
authors.lastname: Feith
authors.forename: J Rüdiger
authors.initials: JR
authors.lastname: Siewert
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000465:Algorithms; D001471:Barrett Esophagus / Q000473:pathology*; D002299:Cardia / Q000473:pathology*; D004396:Coloring Agents; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012394:Rosaniline Dyes; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D013274:Stomach Neoplasms / Q000175:diagnosis*; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D004396:Coloring Agents; D019275:Radiopharmaceuticals; D012394:Rosaniline Dyes; C025484:iso-sulfan blue; D013671:Technetium Tc 99m Sulfur Colloid