Feasibility of a bioadhesive drug delivery system targeted to oesophageal tissue.
This contribution examines the feasibility of utilising an oesophageal-adhesive alginate layer to support model drug particles. Such a bioadhesive system offers the prospect of local drug delivery to the oesophagus, which in turn has applications in the treatment of conditions including gastro-oesophageal reflux disease and oesophageal cancer. Surface-modified (amine, carboxylate and sulfate) as well as neutral fluorescent beads were investigated as model drug particles. A fluorescence assay technique was utilised to quantify the extent and duration of adhesion of a fixed dose of these particles to excised porcine oesophageal tissue. Retention of the particles was investigated both from aqueous systems and within an adhesive alginate solution. After 30 min significantly higher adhesion of neutral beads was recorded from the alginate solution as compared to the aqueous suspension (n = 6, P < 0.05). The beads that possessed a negative charge showed significantly greater retention within the alginate carrier (n = 6, P < 0.05). However, the amine-modified beads showed retention profiles that were similar both within the alginate carrier and within the aqueous suspension (n = 6, P > 0.05).
Batchelor
H K
HK
Medicines Research Unit, Aston University, Birmingham, UK. h.k.batchelor@aston.ac.uk
Tang
M
M
Dettmar
P W
PW
Hampson
F C
FC
Jolliffe
I G
IG
Craig
D Q M
DQ
D000269:Adhesives / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D004947:Esophagus / Q000187:drug effects* / Q000378:metabolism; D005240:Feasibility Studies; D013499:Surface Properties; D013552:Swine
D000269:Adhesives