title: A novel antioxidant-inhibited dexamethasone-mediated and caspase-3-independent muscle cell death.
abstract: Dexamethasone (Dex)-mediated cell death is associated with repression of survival factors (AP-1, c-myc, NF-kappaB). Dex suppressed the activity of genes encoding antioxidant enzymes leading to impaired viability and apoptotic cell death. These findings suggest that reactive oxygen species inhibit protein synthesis and amplify m-calpain-dependent proteolysis. The events that led to death of L6 muscle cells were most likely triggered by Dex-mediated repression of antioxidative defenses on the genomic level.
authors.affiliation: Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, Warsaw, Poland. orzechowski@alpha.sggw.waw.pl
authors.forename: Arkadiusz
authors.initials: A
authors.lastname: Orzechowski
authors.forename: Michal
authors.initials: M
authors.lastname: Jank
authors.forename: Barbara
authors.initials: B
authors.lastname: Gajkowska
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sadkowski
authors.forename: Michal Marek
authors.initials: MM
authors.lastname: Godlewskia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003907:Dexamethasone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D018482:Muscle, Skeletal / Q000166:cytology* / Q000187:drug effects
chemical_list: D000975:Antioxidants; D003907:Dexamethasone; D053148:Caspase 3; D020169:Caspases