Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component.
The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. The possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed.
Frussa-Filho
Roberto
R
Departamento de Farmacologia, Universidade Federal de São Paulo, Rua Botucatu, 862, Edificio Leal Prado, CEP 04023-062, São Paulo, SP, Brazil.
Gonçalves
Michele Themis Moraes
MT
Andersen
Monica Levy
ML
de Araujo
Nilza Pereira
NP
Chinen
Cibele Cristina
CC
Tufik
Sergio
S
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology
D000661:Amphetamine