Inhibitory effect of a polysaccharide from Tinospora cordifolia on experimental metastasis.
Administration of the polysaccharide fraction from Tinospora cordifolia was found to be very effective in reducing the metastatic potential of B16F-10 melanoma cells. There was a 72% inhibition in the metastases formation in the lungs of syngeneic C57BL/6 mice, when the drug was administered simultaneously with tumour challenge. Biochemical parameters such as lung collagen hydroxyproline, hexosamines and uronic acids that are markers of neoplastic development were reduced significantly (P<0.001) in the treated animals compared with the untreated control animals. The treatment could also reduce serum gamma-glutamyltranspeptidase (gamma-GT) and sialic acid levels as compared to the control animals.
Leyon
P V
PV
Department of Immunology, Amala Cancer Research Centre, Amala Nagar PO, Thrissur Dt, Kerala 680 553, India.
Kuttan
G
G
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018547:Plant Stems; D011134:Polysaccharides / Q000302:isolation & purification / Q000627:therapeutic use*; D031610:Tinospora; D023041:Xenograft Model Antitumor Assays / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D011134:Polysaccharides