Doxorubicin prodrug on the basis of tert-butyl cephalosporanate sulfones.
Doxorubicin-cephalosporin prodrug adapted to the development of elastases for the liberation of parent drug was synthesized on the basis of cephalosporanate sulfone esters.
Veinberg
Grigory
G
Latvian Institute of Organic Synthesis, 21 Aizkraukles Street, Riga, LV 1006, Latvia. veinberg@osi.lv
Shestakova
Irina
I
Vorona
Maxim
M
Kanepe
Iveta
I
Domrachova
Ilona
I
Lukevics
Edmunds
E
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology; D004317:Doxorubicin / Q000138:chemical synthesis / Q000494:pharmacology*; D015195:Drug Design; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D002511:Cephalosporins; D004952:Esters; D011355:Prodrugs; D013450:Sulfones; D004317:Doxorubicin; D010196:Pancreatic Elastase