Revival of the regulatory T cell: new targets for drug development.
Compelling new evidence supports the idea that regulatory T cells play a major role in our immune system. Several subsets of these regulators have been identified recently. Differences in the phenotypical and functional characteristics of these subsets have immunological implications. From our growing knowledge of the field of immunology, we could potentially generate a new class of therapeutic agents that target immune-related diseases.
Sutmuller
Roger P M
RP
Department of Tumor Immunology, NCMLS University Medical Center, Post Box 9101 6500HB, Nijmegen, The Netherlands.
Offringa
Rienk
R
Melief
Cornelis J M
CJ
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D016503:Drug Delivery Systems; D006801:Humans; D007108:Immune Tolerance; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000502:physiology; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology
D000276:Adjuvants, Immunologic; D015375:Receptors, Interleukin-2