title: Immunolocalization of angiopoietin 1 in human peritoneal endometriotic lesions.
abstract: OBJECTIVE
  To analyze the expression of angiopoietin 1 (ANGPT1) in pigmented and nonpigmented endometriosis implants and specify its role in the interaction of angiogenic factors.
  
  
  METHODS
  Experimental retrospective study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Eighty-two sections from 201 laparoscopic tissue samples of 43 female patients.
  
  
  METHODS
  Biopsies of peritoneal endometriotic lesions of macroscopically different forms.
  
  
  METHODS
  Angiopoietin 1 expression and location pattern in endothelial cells, periendothelial cells, glandular epithelium, and stromal structures.
  
  
  RESULTS
  Angiopoietin 1 is immunohistochemically detectable in endothelial cells, periendothelial cells, in the glandular epithelium, and in the stroma. Differences in the expression of pigmented and nonpigmented lesions are not statistically significant.
  
  
  CONCLUSIONS
  Pigmented and nonpigmented endometriotic lesions differ according to their clinical activity and angiogenic potential. Angiopoietin 1 is an important representative of the angiogenic factors and is involved in the angiogenic processes of these lesions. There were no significant differences in the expression and location within different lesion types for ANGPT1. Thus, it is not a direct activity marker of a lesion.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. dgescher@ukaachen.de
authors.forename: Dorothee Maria
authors.initials: DM
authors.lastname: Gescher
authors.forename: Uta
authors.initials: U
authors.lastname: Berndorff
authors.forename: Annette
authors.initials: A
authors.lastname: Meyhoefer-Malik
authors.forename: Pierre
authors.initials: P
authors.lastname: Moubayed
authors.forename: Eduard
authors.initials: E
authors.lastname: Malik
mesh_terms: D000328:Adult; D042683:Angiopoietin-1 / Q000378:metabolism*; D001706:Biopsy; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010532:Peritoneal Diseases / Q000378:metabolism* / Q000473:pathology; D010537:Peritoneum / Q000378:metabolism / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D042683:Angiopoietin-1