The matrix metalloproteinase-21 gene 572C/T polymorphism and the risk of breast cancer.
BACKGROUND
Matrix metalloproteinases (MMPs) contribute in multiple ways to all stages of tumor development, and a number of DNA polymorphisms in the MMP genes are associated with an increased risk of cancer. We previously identified the MMP-21 gene 572C/T polymorphism leading to Ala191Val substitution within the enzyme's catalytic domain. We performed a case-control study to test association between this polymorphism and the risk of breast cancer.


METHODS
572C/T polymorphism was analyzed by RFLP method in 396 unrelated Russian females: 76 breast cancer patients and 320 disease-free blood donors.


RESULTS
The frequencies of C/C, T/C and T/T genotypes in patients (69.7%, 25.0% and 5.3%) did not differ significantly from those in controls (61.9%, 34.7% and 3.4%); the polymorphism was not associated with the increased tumor size and the presence of metastases.


CONCLUSIONS
The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer.
Shagisultanova
Elena I
EI
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Novikova
Inna A
IA
Sidorenko
Yuri S
YS
Marchenko
George N
GN
Strongin
Alex Y
AY
Malkhosyan
Sergei R
SR
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics*; D053505:Matrix Metalloproteinases, Secreted; D008875:Middle Aged; D011110:Polymorphism, Genetic
C471969:MMP21 protein, human; D020782:Matrix Metalloproteinases; D053505:Matrix Metalloproteinases, Secreted