Medications that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update.
OBJECTIVE
To provide an updated list of the highly toxic medications in North America that can kill a 10 kg toddler upon ingestion of 1-2 dose units.


METHODS
All drugs available in North America were reviewed and their reported lethal doses in children or adults (where no pediatric data existed) were identified. The dose units of drugs available in North America were subsequently identified, followed by those dose units that could kill a toddler upon ingestion of 1-2 dose units or teaspoonfuls.


RESULTS
Tricyclic antidepressants, antipsychotics, quinine derivatives, calcium channel blockers, opioids, and oral hypoglycemics can kill a toddler with 1-2 dose units. This list of drugs was responsible for 40% of toddler fatalities reported to the American Association of Poison Control Center Toxic Exposure Surveillance System between 1990-2000.


CONCLUSIONS
Drugs that can kill a toddler with 1-2 dose units should be known to clinicians as such exposures warrant immediate and intensive management. A new system of special labeling of these drugs should be considered.
Bar-Oz
Benjamin
B
The Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada.
Levichek
Zina
Z
Koren
Gideon
G
D000284:Administration, Oral; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000506:poisoning; D000847:Annual Reports as Topic; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000506:poisoning; D000962:Antimalarials / Q000008:administration & dosage / Q000506:poisoning; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000506:poisoning; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000506:poisoning; D002423:Cause of Death; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D058085:Iron Compounds / Q000008:administration & dosage / Q000506:poisoning; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000145:classification; D011039:Poison Control Centers / Q000706:statistics & numerical data; D011041:Poisoning / Q000401:mortality*; D012189:Retrospective Studies; D013607:Tablets / Q000008:administration & dosage / Q000009:adverse effects
D000701:Analgesics, Opioid; D000889:Anti-Arrhythmia Agents; D000929:Antidepressive Agents, Tricyclic; D000962:Antimalarials; D014150:Antipsychotic Agents; D002121:Calcium Channel Blockers; D058085:Iron Compounds; D004364:Pharmaceutical Preparations; D013607:Tablets