Evaluation of O-[11C]methyl-L-tyrosine and O-[18F]fluoromethyl-L-tyrosine as tumor imaging tracers by PET.
We investigated the potential of O-[(11)C]methyl-L-tyrosine and O-[(18) F]fluoromethyl-L-tyrosine as positron-emitting tracers for tumor imaging. The two tracers had similar distribution patterns in rats bearing AH109A hepatoma, with pancreas and, on a lesser extent, AH109A showing the highest uptake. Uptake of both tracers in the AH109A and uptake ratios of AH109A-to-tissues (with the exception of AH109A-to-bone) gradually increased for 60 min. O-[(11)C]methyl-L-tyrosine was metabolically stable, whereas a negligible low amount of metabolites was observed for O-[(18)F]fluoromethyl-L-tyrosine. Both tracers showed the potential for tumor imaging.
Ishiwata
Kiichi
K
Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1-1 Naka-cho, Itabashi-ku, Tokyo 173-0022, Japan. ishiwata@pet.tmig.or.jp
Kawamura
Kazunori
K
Wang
Wei-Fang
WF
Furumoto
Shozo
S
Kubota
Kazuo
K
Pascali
Claudio
C
Bogni
Anna
A
Iwata
Ren
R
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000378:metabolism*; D045744:Cell Line, Tumor; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008815:Mice, Inbred Strains; D009928:Organ Specificity; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*
C493092:O-(11C)methyl-L-tyrosine; C493093:O-(18F)fluoromethyl-L-tyrosine; D019275:Radiopharmaceuticals; D014443:Tyrosine