title: B-cell immunoblastic lymphoma with multinucleated giant cells in a cat.
abstract: A 10-year-old male mixed breed cat died after six months history of intermittent vomiting and weight loss. At necropsy, large white-colored foci were found in both kidneys, and whitish thickening of the gastric wall was present at the pyloric part of the stomach. Histopathological examination revealed that both lesions consisted of proliferation of large-sized neoplastic lymphocytes intermingled with multinucleated giant cells. Immunohistochemically, the neoplastic cells were positive for both B-cell antigen receptor complex (CD 79 alpha cy) and MHC class II, although multinucleated giant cells were negative. The present case was diagnosed as B-cell immunoblastic lymphoma with multinucleated giant cells.
authors.affiliation: Department of Veterinary Pathology, Tottori University, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohshima
authors.forename: Takehito
authors.initials: T
authors.lastname: Morita
authors.forename: Masumi
authors.initials: M
authors.lastname: Sawada
authors.forename: Akinori
authors.initials: A
authors.lastname: Shimada
authors.forename: Hideko
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Kou
authors.initials: K
authors.lastname: Sawashima
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D015726:Giant Cells / Q000473:pathology*; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000662:veterinary*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000473:pathology / Q000662:veterinary*; D013270:Stomach / Q000473:pathology