title: The effectiveness of polyethylene versus titanium particles in inducing osteolysis in vivo.
abstract: Bearing surface wear and periprosthetic osteolysis due to wear particles are among the most common reasons for joint replacement failure. A murine calvarial model of wear particle-induced osteolysis has been used to identify different biologic factors associated with this problem and to test nonsurgical methods of modulating the host response to particulate debris. This model has utilized titanium particles, however, in clinical practice the most common source of particulate debris is polyethylene particles from bearing surface wear. We now report a calvarial model of wear particle-induced osteolysis based on commercially available polyethylene particles. We found that compared to sham surgery osteoclast recruitment and bone resorption can be induced by introduction of the titanium particles or polyethylene particles. However, bone resorption was significantly higher with polyethylene particles compared to titanium particles (p=0.02). We consider the polyethylene based murine calvarial model of wear particle-induced osteolysis a reliable and clinically relevant tool to understand the host factors and potential pharmacologic interventions that can influence wear debris generated osteolysis. This model might serve as an extension of the well-established titanium based bone resorption model.
authors.affiliation: Department of Orthopaedics, Mayo Clinic Rochester, Medical Sciences Building 3-69, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Marius
authors.initials: M
authors.lastname: von Knoch
authors.forename: Donna E
authors.initials: DE
authors.lastname: Jewison
authors.forename: Jean D
authors.initials: JD
authors.lastname: Sibonga
authors.forename: Christoph
authors.initials: C
authors.lastname: Sprecher
authors.forename: Bernard F
authors.initials: BF
authors.lastname: Morrey
authors.forename: Franz
authors.initials: F
authors.lastname: Loer
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Berry
authors.forename: Sean P
authors.initials: SP
authors.lastname: Scully
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D015743:Giant Cells, Foreign-Body / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010014:Osteolysis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D010316:Particle Size; D020959:Polyethylene / Q000009:adverse effects*; D012886:Skull / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D014025:Titanium / Q000009:adverse effects*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D020959:Polyethylene; D014025:Titanium