title: Fat oxidation in obesity: druggable or risky enterprise?
abstract: Two potential approaches for the treatment of obesity are presented, in which modulation of a target increases fatty acid oxidation. These two methods, which are here referred to as 'pull' and 'push' routes, involve creating a demand for fuel by uncoupling oxidation from ATP production ('pulling'), or shuttling fatty acyl CoA into the mitochondria by an afferent mechanism ('pushing'). Proof-of-principle studies in humans are required to assess the use of these approaches in weight loss maintenance.
authors.affiliation: AstraZeneca R&D Molndal, Department of Molecular Pharmacology, Molndal, S-431 83, Sweden. john.clapham@astrazeneca.com
authors.forename: John C
authors.initials: JC
authors.lastname: Clapham
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D005227:Fatty Acids