title: High frequency of mutations of the PIK3CA gene in human cancers.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.
authors.forename: Yardena
authors.initials: Y
authors.lastname: Samuels
authors.forename: Zhenghe
authors.initials: Z
authors.lastname: Wang
authors.forename: Alberto
authors.initials: A
authors.lastname: Bardelli
authors.forename: Natalie
authors.initials: N
authors.lastname: Silliman
authors.forename: Janine
authors.initials: J
authors.lastname: Ptak
authors.forename: Steve
authors.initials: S
authors.lastname: Szabo
authors.forename: Hai
authors.initials: H
authors.lastname: Yan
authors.forename: Adi
authors.initials: A
authors.lastname: Gazdar
authors.forename: Steven M
authors.initials: SM
authors.lastname: Powell
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Riggins
authors.forename: James K V
authors.initials: JK
authors.lastname: Willson
authors.forename: Sanford
authors.initials: S
authors.lastname: Markowitz
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Kinzler
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
authors.forename: Victor E
authors.initials: VE
authors.lastname: Velculescu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D020134:Catalytic Domain; D058534:Class I Phosphatidylinositol 3-Kinases; D015179:Colorectal Neoplasms / Q000235:genetics; D005909:Glioblastoma / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D013274:Stomach Neoplasms / Q000235:genetics
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human