Architecture of secondary lymphoid tissue in sheep experimentally challenged with scrapie.
Scrapie is a transmissible spongiform encephalopathy in which there is an accumulation of the abnormal form of the prion protein, PrPsc, in the lymphoreticular system and nervous system. There is a particular accumulation of PrPsc on follicular dendritic cells within the germinal centre of B-cell follicles. Because accumulation of PrPsc in the nervous system leads to neuronal cell loss we have examined PrPsc accumulation in the prescapular and mesenteric lymph nodes in relation to lymph node architecture of scrapie-challenged sheep. We demonstrate that an accumulation of PrPsc in the lymph node fails to result in gross defects in the microanatomy and phenotype of T- and B-cell areas in the lymph nodes.
Davies
Marie L
ML
Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK.
Hopkins
Lee J
LJ
Halliday
Sue
S
Houston
Fiona
F
Hunter
Nora
N
McConnell
Ian
I
D000818:Animals; D001402:B-Lymphocytes / Q000473:pathology; D005260:Female; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008643:Mesentery; D018620:PrPSc Proteins / Q000378:metabolism; D012540:Scapula; D012608:Scrapie / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D012756:Sheep; D016176:T-Lymphocyte Subsets / Q000473:pathology
D018620:PrPSc Proteins