title: [Association of humans leucocitary antigens with humoral nonresponsive to hepatitis B vaccine in chronic hemodialysis patients].
abstract: Vaccination using surface antigen from hepatitis B virus has not been successfully responded by hemodialysis patients. The present study was aimed at assessing a possible relationship between human leukocyte antigens and the low production of protective antibodies (anti-HbS) against the surface antigen from hepatitis B by patients with chronic renal failure submitted to hemodialysis programs. The antigens HLA-DR and HLA-DQ were identified in 76 hemodialysis patients through classic microlymphotoxicity. Our results showed that 34.2% of the patients were non-responsive to the vaccine VHB. The most frequent HLA specificity were: HLA-DR3, DR-7 and DQ2 with a significant association for HLA-DR3 (p=0.0025; OR 5.1; IC 95% 1.36-19.10). Such data suggest an association between genes from HLA class II antigens and the humoral non-response to the vaccine VHB.
authors.affiliation: Universidade Federal do Piauí, Teresina, PI, Brasil.
authors.forename: Joaquim Xavier
authors.initials: JX
authors.lastname: de Sousa Júnior
authors.forename: José Tibúrcio
authors.initials: JT
authors.lastname: de Monte Neto
authors.forename: José Adail Fonseca
authors.initials: JA
authors.lastname: de Castro
authors.forename: Hélida Monteiro
authors.initials: HM
authors.lastname: de Andrade
authors.forename: Semiramis Jamil Hadad
authors.initials: SJ
authors.lastname: do Monte
mesh_terms: D000939:Epitopes; D006680:HLA Antigens / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis* / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000008:administration & dosage / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D010641:Phenotype; D006435:Renal Dialysis / Q000009:adverse effects
chemical_list: D000939:Epitopes; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines