Isoprostanes and the liver.
The liver has been central to our understanding of the physiology and biology of the F2-isoprostanes. The discovery of F2-IsoPs and the initial demonstration that they could be used to localize oxidative stress was first demonstrated in a rat model of oxidative liver injury (carbon tetrachloride), and the first demonstration that plasma concentrations are increased in a human disease was in patients with liver failure and the hepatorenal syndrome [J. Clin. Invest. 90 (6) (1992b) 2502; J. Lipid Mediat. 6 (1/3) (1993) 417]. This article will cover the measurement of F2-IsoPs as markers of lipid peroxidation in vivo in liver disease, and review their biological activity as mediators of disease.
Moore
Kevin
K
Centre for Hepatology, Royal Free and University College Medical School, University College London, London, UK. kmoore@rfc.ucl.ac.uk.2
D000818:Animals; D006801:Humans; D028421:Isoprostanes / Q000097:blood / Q000502:physiology*; D008099:Liver / Q000502:physiology*; D008107:Liver Diseases / Q000097:blood / Q000503:physiopathology; D018384:Oxidative Stress; D051381:Rats
D028421:Isoprostanes