title: Therapeutic ultrasound to stimulate osteoconduction; A placebo controlled single blind study using e-PTFE membranes in rats.
abstract: To decrease healing time of bone defects covered with osteoconductive membranes, an attempt was made to stimulate the osteoconductive process with therapeutic ultrasound. In 72 rats, a circular mandibular defect was created and covered on both sides with an e-PTFE membrane. A control group, an ultrasound treatment group and a placebo treatment group were studied. At 2 and 4 weeks, the osteoconduction was expressed as the percentage of defect closure using digitized microradiographs. At 2 weeks, there was no significant difference in the percentage of defect closure between the groups. At 4 weeks, there was significantly more bone defect closure in the placebo group (77.9%) as compared to the control group (59.3%). Membrane ultrasound attenuation measurements indicated that the membrane blocks most of the applied ultrasound. In conclusion, low intensity pulsed ultrasound does not appear to significantly stimulate osteoconduction into a bone defect in the rat mandible that is covered by an e-PTFE membrane.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands. j.schortinghuis@kchir.azg.nl
authors.forename: Jurjen
authors.initials: J
authors.lastname: Schortinghuis
authors.forename: Jan L
authors.initials: JL
authors.lastname: Ruben
authors.forename: Gerry M
authors.initials: GM
authors.lastname: Raghoebar
authors.forename: Boudewijn
authors.initials: B
authors.lastname: Stegenga
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D004195:Disease Models, Animal; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000503:physiopathology; D008338:Mandibular Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D008567:Membranes, Artificial; D008852:Microradiography / Q000379:methods; D011138:Polytetrafluoroethylene; D051381:Rats; D017207:Rats, Sprague-Dawley; D016037:Single-Blind Method; D013997:Time Factors; D014464:Ultrasonic Therapy / Q000379:methods*; D014945:Wound Healing / Q000502:physiology
chemical_list: D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene