[Unitary-core osmotic pump tablet for controlled release of water-insoluble drug].
OBJECTIVE
To study unitary-core osmotic pump tablet for delivering water-insoluble drug for 24 hours.


METHODS
Unitary-core osmotic pump tablet was prepared using nifedipine as the model drug. The effects of various core formulation variables on drug release were studied.


RESULTS
Polyethylene oxide and potassium chloride have comparable positive effects on drug release, whereas, nifedipine has markedly negative effect on drug release.


CONCLUSIONS
Unitary-core osmotic pump tablet is very easy in preparation and it can deliver water-insoluble drug in substantially constant rate for 24 hours.
Liu
Long-xiao
LX
College of Pharmaceutical Science, Zhejiang University, Hangzhou 310027, China. liulx@zju.edu.cn
Xu
Qing
Q
Khang
Gilson
G
Rhee
John-moon
JM
Lee
Hai-bang
HB
D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D009543:Nifedipine / Q000008:administration & dosage* / Q000737:chemistry; D009995:Osmosis; D011092:Polyethylene Glycols / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D013607:Tablets; D011092:Polyethylene Glycols; D011189:Potassium Chloride; D009543:Nifedipine