Intensive investigation of bacterial foodborne disease outbreaks: proposed guidelines and tools for the collection of dose-response data by local health departments.
Local health departments that investigate foodborne disease outbreaks do not have adequate guidelines for collecting data that could be used to estimate dose-response relationships, a key component of hazard characterization in quantitative microbial risk assessment. To meet this need, criteria and a questionnaire template for the collection of appropriate dose-response data in the context of outbreaks were developed and applied in the investigation of a point-source outbreak linked to Salmonella serotype Enteritidis in a salmon entrée in February 2000. In this outbreak, the attack rate and risk of hospitalization increased with the amount of salmon entrée consumed, and detailed data were obtained on illness severity measures and host susceptibility factors. Local health departments might consider broadening investigations to include the collection of additional data when investigating outbreaks that have met a specific set of conditions. These data could provide information needed by federal regulatory agencies and other organizations for quantitative microbial risk assessment. Intensive investigations of outbreaks could prevent future illnesses by providing information needed to develop approaches to minimizing risk.
Jones
Roderick C
RC
Chicago Department of Public Health, 2160 West Ogden Avenue, Chicago, Illinois 60612, USA. Jones_Roderick@cdph.org
Gerber
Susan I
SI
Diaz
Pamela S
PS
Williams
Larry L
LL
Dennis
Sherri B
SB
Parish
Eileen S
ES
Paul
William S
WS
D002641:Chicago / Q000453:epidemiology; D015169:Colony Count, Microbial; D003257:Consumer Product Safety; D003625:Data Collection; D004196:Disease Outbreaks; D005511:Food Handling / Q000379:methods; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000453:epidemiology / Q000517:prevention & control*; D005544:Forecasting; D017408:Guidelines as Topic; D006801:Humans; D018570:Risk Assessment / Q000379:methods*; D012478:Salmonella Food Poisoning / Q000453:epidemiology / Q000517:prevention & control; D013997:Time Factors