title: Chemoenzymatic dynamic kinetic resolution.
abstract: During the past decade a new concept has appeared in asymmetric catalysis involving the combination of a biocatalyst and a chemocatalyst in one 'pot' leading to efficient deracemization via dynamic kinetic resolution (DKR). Here, we outline the different strategies that have been developed for efficient chemoenzymatic DKR, in particular the powerful combination of an enzyme and a metal catalyst.
authors.affiliation: Department of Physical and Inorganic Chemistry, Rovira i Virgili University, Pl. Imperial Tarraco 1, 43005 Tarragona, Spain.
authors.forename: Oscar
authors.initials: O
authors.lastname: Pàmies
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
mesh_terms: D001711:Biotransformation; D016956:Burkholderia cepacia / Q000201:enzymology; D002384:Catalysis; D002625:Chemistry, Organic / Q000379:methods; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D004951:Esterification; D005656:Fungal Proteins; D006859:Hydrogen / Q000737:chemistry; D007700:Kinetics; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D008956:Models, Chemical; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D004798:Enzymes; D005656:Fungal Proteins; D010165:Palladium; D012428:Ruthenium; D006859:Hydrogen; D008049:Lipase; C431349:lipase B, Candida antarctica