Molecular pharmacology of isoprostanes in vascular smooth muscle.
Isoprostanes are marker of lipid peroxidation and are produced after free-radical attack of membrane lipids. In addition, they are biologically active and are essentially vaso- and broncho-constrictor. Their smooth muscle constrictor actions are closely linked to the activation of the thromboxane A(2) receptor, but also involve a distinct receptor not yet identified. The response of vascular smooth muscle to isoprostanes is subclass-specific (F-series versus E-series isoprostanes) and cell- and species-related. In this review, we will address the vascular actions of isoprostanes and their possible role in vascular physiology and pathophysiology.
Habib
Aïda
A
Department of Internal Medicine, American University of Beirut, P.O. Box 11-236, Beirut, Lebanon. ah31@aub.edu.lb
Badr
Kamal F
KF
D000818:Animals; D006801:Humans; D028421:Isoprostanes / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects
D028421:Isoprostanes