Multiple and surprising new functions for emerin, a nuclear membrane protein.
Emerin is an integral protein of the nuclear inner membrane. Emerin is not essential, but its loss of function causes Emery-Dreifuss muscular dystrophy. We summarize significant recent progress in understanding emerin, which was previously known to interact with barrier-to-autointegration factor and lamins. New partners include transcription repressors, an mRNA splicing regulator, a nuclear membrane protein named nesprin, nuclear myosin I and F-actin. These interactors imply multiple roles for emerin in the nucleus, some of which overlap with related LEM-domain proteins.
Bengtsson
Luiza
L
Department of Cell Biology, WBSB room G-9, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD 21205, USA.
Wilson
Katherine L
KL
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D034882:Lamins / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D020389:Muscular Dystrophy, Emery-Dreifuss / Q000209:etiology; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013946:Thymopoietins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
C501959:BANF1 protein, human; D004268:DNA-Binding Proteins; D034882:Lamins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D013946:Thymopoietins; C092710:emerin