Agmatine-morphine interaction on nociception in mice.
The aim of this study was to investigate the possible participation of nitric oxide in the agmatine-mediated potentiation of morphine-induced analgesia in mice. Agmatine and L-NAME (a nitric oxide synthesis inhibitor) enhanced morphine-induced analgesia in the tail flick test, but not in the hot plate test. L-NAME did not block the agmatine-induced potentiation of morphine effect. Our results indicate that agmatine potentiates morphine-induced spinal but not supraspinal analgesia, and that this effect is not mediated by a nitric oxide-dependent mechanism.
Ruiz-Durantez
Eduardo
E
Department of Pharmacology, Faculty of Medicine, University of the Basque Country, Leioa, Vizcaya, Spain.
Llorente
Javier
J
Ulibarri
Isabel
I
Pineda
Joseba
J
Ugedo
Luisa
L
D000376:Agmatine / Q000378:metabolism*; D000698:Analgesia; D000701:Analgesics, Opioid / Q000378:metabolism*; D000818:Animals; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000378:metabolism; D051379:Mice; D009020:Morphine / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D010146:Pain / Q000378:metabolism*; D010147:Pain Measurement
D000701:Analgesics, Opioid; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D000376:Agmatine; D009020:Morphine; D019331:NG-Nitroarginine Methyl Ester