title: [Clinical evaluation of three methods of fine-needle aspiration, large-core needle biopsy and frozen section biopsy with focus staining for non-palpable breast disease].
abstract: OBJECTIVE
  Early detection of breast cancer is crucial to improve the therapeutic effect and to increase the survival rate. However, it is difficult because breast cancer in early stage was usually occult, impalpable, and could not be detected by laboratory test. This study was designed to compare the effectiveness of three methods for diagnosis of non-palpable breast cancer.
  
  
  METHODS
  Twenty-four patients with impalpable breast mass suggested by computer-aided stereotactic mammography were performed with three kinds of methods, including fine-needle aspiration cytology (FNAC), large-core needle biopsy (LCNB), and frozen section biopsy (FSB) with focus staining. The results were compared with postoperative pathology.
  
  
  RESULTS
  Compared with postoperative pathology results, the diagnostic consistent rates of FNAC, LCNB and FSB with staining focus were 75%, 92%, and 100%, respectively (P< 0.05).
  
  
  CONCLUSIONS
  Frozen section with focus staining guided by computer-aided stereotactic mammography was the effective diagnostic technique for non-palpable breast cancer.
authors.affiliation: Department of Diagnostic Imaging & Intervention, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China. wyaopan@mail.china.com
authors.forename: Yao-Pan
authors.initials: YP
authors.lastname: Wu
authors.forename: Pei-Qiang
authors.initials: PQ
authors.lastname: Cai
authors.forename: Wei-Zhang
authors.initials: WZ
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Yang-Kui
authors.initials: YK
authors.lastname: Gu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Jie-Hua
authors.initials: JH
authors.lastname: He
authors.forename: Hao-Gao
authors.initials: HG
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000009:adverse effects / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008875:Middle Aged; D010173:Palpation