The expression of the nuclear oncogenes c-myc and c-jun in the groove of Ranvier of the rabbit growth plate.
An immunohistochemical technique has been used to localise nuclear oncoproteins in the groove of Ranvier. The densely packed cells deep in the groove were immunoreactive positive for the myc protein. Cells and matrix in the same location were immunoreactive positive for the jun protein. These findings confirm the presence of proliferating cells in the groove. Injury to these cells is probably responsible for growth disturbances associated with trauma.
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Orthopaedic Surgery Unit, The Glenfield Hospital, Groby Road, Leicester, UK.
D000818:Animals; D002356:Cartilage / Q000166:cytology / Q000378:metabolism; D018483:Diaphyses / Q000166:cytology / Q000378:metabolism; D004838:Epiphyses / Q000166:cytology / Q000378:metabolism; D005269:Femur / Q000166:cytology / Q000378:metabolism; D006132:Growth Plate / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D023421:Models, Animal; D015530:Nuclear Matrix / Q000378:metabolism; D010865:Pilot Projects; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis*; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D011817:Rabbits; D011901:Ranvier's Nodes / Q000378:metabolism*; D013977:Tibia / Q000166:cytology / Q000378:metabolism
D016755:Proto-Oncogene Proteins c-jun; D016271:Proto-Oncogene Proteins c-myc