Effects of sodium benzoate on the complications of 1.5% glycine solution using two different intravesical pressures during bladder irrigation.
BACKGROUND
In this experimental study we researched the effects of sodium benzoate on the complications of 1.5% glycine solution using with two different intravesical pressures during bladder irrigation.


METHODS
Thirty-six male adult New Zealand rabbits with body weight ranging from 1500 to 2800 g were used in the experiments. The rabbits were randomly allocated to four groups. In groups 1 and 2, 500 ml of 1.5% gylcine was used as irrigating fluid during 30 min, but only group 2 received 500 mg kg(-1) of sodium benzoate treatment by oral route immediately after irrigation. In groups 3 and 4, 500 ml of 1.5% glycine was used as irrigating fluid during 60 min, but only group 4 received the same treatment as group 2. Ammonia, urea, sodium, potassium, hemoglobin, hemotocrit and platelet levels were studied at preirrigation and postirrigation on the 4 h and 24 h. Also electrocardiographic (ECG) changes were monitored at the same time with blood parameters.


RESULTS
At 4 h postirrigation, Na+ levels were decreased significantly in group 1 and non-significantly in group 3 when compared with preirrigation levels. But these levels were not changed in groups 2 and 4. Both at 4 h and 24 h, ammonia and urea levels were significantly increased in groups 1 and 3. Ammonia level was decreased but the urea level was not changed in groups 2 and 4 at the same time points. K+ level was significantly changed only in group 1 at 4 h and 24 h. Hemoglobin and hemotocrit concentrations were decreased both at 4 h and 24 h compared with preirrigation levels in all groups. Also there were ECG changes between the treated and untreated groups.


CONCLUSIONS
Sodium benzoate was very effective against the complications of 1.5% glycine during bladder irrigation experimentally. But this needs further investigation, especially for the applicability of this new treatment model in human TURP syndrome.
Yagmurdur
H
H
The Ministry of Health Ankara Research and Training Hospital, Clinic of Anesthesiology and Reanimation, Ankara, Turkey. mcyagmurdur@hotmail.com
Ceyhan
A
A
Dagli
G
G
Yuksel
U
U
Altunatmaz
K
K
Ide
T
T
Unal
N
N
D000283:Administration, Intravesical; D000641:Ammonia / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions / Q000502:physiology; D004562:Electrocardiography; D005998:Glycine / Q000008:administration & dosage* / Q000009:adverse effects; D006454:Hemoglobins / Q000187:drug effects; D008297:Male; D011188:Potassium / Q000097:blood; D011312:Pressure; D011817:Rabbits; D012964:Sodium / Q000097:blood; D020160:Sodium Benzoate / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D007507:Therapeutic Irrigation / Q000379:methods; D013997:Time Factors; D014508:Urea / Q000097:blood; D001743:Urinary Bladder / Q000187:drug effects*
D000935:Antifungal Agents; D006454:Hemoglobins; D000641:Ammonia; D014508:Urea; D012964:Sodium; D020160:Sodium Benzoate; D011188:Potassium; D005998:Glycine