title: The UK Endovascular Aneurysm Repair (EVAR) trials: design, methodology and progress.
abstract: OBJECTIVE
  The endovascular aneurysm repair (EVAR) trials aim to assess the efficacy of EVAR in the treatment of AAA in terms of mortality, quality of life, durability and cost-effectiveness.
  
  
  METHODS
  Male and female patients aged at least 60 years with an AAA diameter measuring at least 5.5 cm on a computed tomography (CT) scan are assessed for anatomical suitability for EVAR. Suitable patients are offered entry either into EVAR Trial 1 if they are considered fit for conventional open repair or EVAR Trial 2 if they are considered unfit. EVAR 1 randomly allocates patients to EVAR or open repair and EVAR 2 randomly allocates patients to EVAR with best medical treatment or best medical treatment alone. Target recruitment for EVAR Trials 1 and 2 is 900 and 280 patients, respectively.
  
  
  RESULTS
  Recruitment began in September 1999 and there are currently 40 UK centres participating in the trials. Monthly targets are being exceeded in EVAR Trial 1 with 1037 patients randomised by October 2003. EVAR Trial 2 is also meeting monthly targets with a total of 319 patients randomised. When recruitment closes in December 2003 patients will need to be followed for at least 1 year from their operation. Publication of full results for both trials is expected in mid 2005.
authors.affiliation: Imperial College of Science, Technology and Medicine, London, UK.
authors.forename: L C
authors.initials: LC
authors.lastname: Brown
authors.forename: D
authors.initials: D
authors.lastname: Epstein
authors.forename: A
authors.initials: A
authors.lastname: Manca
authors.forename: J D
authors.initials: JD
authors.lastname: Beard
authors.forename: J T
authors.initials: JT
authors.lastname: Powell
authors.forename: R M
authors.initials: RM
authors.lastname: Greenhalgh
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000191:economics / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000191:economics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D012107:Research Design; D006113:United Kingdom