title: [Studies on variation of danshensu content in accelerated stability tests].
abstract: OBJECTIVE
  To study the variation Laws of content of danshensu accelerated in control and in danshen injection in order to provide reference for stability investigation of danshensu.
  
  
  METHODS
  The tests was carried out by classic isothermal method and the content of danshensu was determined by HPLC.
  
  
  RESULTS
  The contents of danshensu in accelerated tests increase in control and decrease in danshen injection respectively.
  
  
  CONCLUSIONS
  The component of phenic acidity would be hydrolyzed to become danshensu in the accelerated tests. Much attention should be paid to the unusual increase when studies of danshen preparations are carried out.
authors.affiliation: Pharmaceutical Laboratory of Chinese Materia Medica, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Sheng-jun
authors.initials: SJ
authors.lastname: Mao
authors.forename: Shi-xiang
authors.initials: SX
authors.lastname: Hou
authors.forename: Chang-jiong
authors.initials: CJ
authors.lastname: Tang
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Huang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006868:Hydrolysis; D062385:Hydroxybenzoates / Q000737:chemistry; D007267:Injections; D007773:Lactates / Q000008:administration & dosage / Q000032:analysis* / Q000737:chemistry; D013696:Temperature
chemical_list: D062385:Hydroxybenzoates; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid; C017616:phenolic acid