Global approach to multichannel electroencephalogram analysis for diagnosis and clinical evaluation in mild Alzheimer's disease.
To establish an early diagnosis of Alzheimer's disease (AD), we evaluated brain spatial dynamics and cognitive function in mild AD. Seventeen patients with the diagnosis of mild AD and 17 age-matched controls were examined for Omega (global complexity), Sigma (total power) and Phi (generalized frequency) by 19-channel electroencephalography (EEG). As a result, the mild AD group showed significantly higher Omega values than the control group. The Phi values were highly correlated with the Mini-Mental State Examination scores and the full IQ and performance IQ scores of the Japanese Wechsler Adult Intelligence Scale Revised. These results indicate an increase in spatial complexity of the brain electric field in mild AD, as well as a close relationship between slowing of the global frequency of field changes and the cognitive decline in mild AD.
Yoshimura
Masafumi
M
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan. yoshimum@takii.kmu.ac.jp
Isotani
Toshiaki
T
Yagyu
Takami
T
Irisawa
Satoshi
S
Yoshida
Tsunetaka
T
Sugiyama
Masao
M
Minami
Tomohisa
T
Sugimoto
Tatsuya
T
Nobuhara
Kenji
K
Okugawa
Gaku
G
Kinoshita
Toshihiko
T
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D001921:Brain / Q000033:anatomy & histology / Q000503:physiopathology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000209:etiology*; D003937:Diagnosis, Differential; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology; D007361:Intelligence Tests; D008297:Male; D008609:Mental Status Schedule; D009483:Neuropsychological Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric