title: The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols.
abstract: Downregulation of iNOS and NO is a pathway common for flavones and polyphenols, two distinct families of phytoalexins. Our data suggest that inhibition of the NO pathway could be one of the mechanisms involved in the proapoptotic properties of these phytoalexins in leukemia B-cells.
authors.affiliation: INSERM E355, Centre Biomédicale des Cordeliers, Paris, France. christian.billard@bhdc.jussieu.fr
authors.forename: Christian
authors.initials: C
authors.lastname: Billard
authors.forename: Claire
authors.initials: C
authors.lastname: Quiney
authors.forename: Ruoping
authors.initials: R
authors.lastname: Tang
authors.forename: Catherine
authors.initials: C
authors.lastname: Kern
authors.forename: Florence
authors.initials: F
authors.lastname: Ajchenbaum-Cymbalista
authors.forename: Daniel
authors.initials: D
authors.lastname: Dauzonne
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Kolb
mesh_terms: D000970:Antineoplastic Agents / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology / Q000473:pathology; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D010636:Phenols / Q000494:pharmacology*; D010880:Piperidines / Q000633:toxicity*; D059808:Polyphenols
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D010636:Phenols; D010880:Piperidines; D059808:Polyphenols; C077990:alvocidib; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II