title: Heart rate dependent modification of the QTc cut-off values can improve accurate evaluation of QT prolongation.
abstract: Significant amounts of over- and underestimation to detect QT prolongation were observed using Bazett's formula or Fridericia's formula for heart rate correction with any fixed QTc cut-off value. Heart rate dependent modification of the QTc cut-off values can improve accurate evaluation of QT prolongation.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Higashi-Ku, Fukuoka, Japan. kamefu@rb3.so-net.ne.jp
authors.forename: Tsuneaki
authors.initials: T
authors.lastname: Sadanaga
authors.forename: Fumiko
authors.initials: F
authors.lastname: Sadanaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yao
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004562:Electrocardiography / Q000592:standards*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000494:pharmacology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D011619:Psychotropic Drugs