Do we need additional markers of myocyte necrosis: the potential value of heart fatty-acid-binding protein.
Heart fatty-acid-binding protein (FABP) is a small cytosolic protein that is abundant in the heart and has low concentrations in the blood and in tissues outside the heart. It appears in the blood as early as 1.5 h after onset of symptoms of infarction, peaks around 6 h and returns to baseline values in 24 h. These features of H-FABP make it an excellent potential candidate for the detection of acute myocardial infarction (AMI). We review the strengths and weaknesses of H-FABP as a clinically applicable marker of myocyte necrosis in the context of acute coronary syndromes.
Alhadi
H A
HA
Cardiovascular Research Unit, Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.
Fox
K A A
KA
D000208:Acute Disease; D000789:Angina, Unstable / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay / Q000592:standards; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D032383:Myocytes, Cardiac / Q000473:pathology*; D009336:Necrosis; D011237:Predictive Value of Tests
D015415:Biomarkers; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins