title: Progressive multifocal leukoencephalopathy successfully treated with highly active antiretroviral therapy and cidofovir in an adolescent infected with perinatal human immunodeficiency virus (HIV).
abstract: Progressive multifocal leukoencephalopathy is an infectious demyelinating brain disease caused by the JC virus that is associated with significant morbidity and mortality in the immunocompromised host. We report a case of progressive multifocal leukoencephalopathy successfully treated with highly active antiretroviral therapy and cidofovir in an adolescent patient perinatally infected with human immunodeficiency virus (HIV).
authors.affiliation: Department of Pediatrics, College of Physicians and Surgeons, Columbia University, Harlem Hospital Center, New York, New York 10025, USA. lr2043@columbia.edu
authors.forename: Lisa-Gaye
authors.initials: LG
authors.lastname: Robinson
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Chiriboga
authors.forename: Susan E
authors.initials: SE
authors.lastname: Champion
authors.forename: Ivan
authors.initials: I
authors.lastname: Ainyette
authors.forename: Monica
authors.initials: M
authors.lastname: DiGrado
authors.forename: Elaine J
authors.initials: EJ
authors.lastname: Abrams
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy*; D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007089:Image Enhancement; D018445:Infectious Disease Transmission, Vertical; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D009483:Neuropsychological Tests; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir