Post-prandial plasma ghrelin levels in people with different breakfast hours.
OBJECTIVE
To investigate the changes in post-meal plasma ghrelin levels in people with different breakfast hours.


METHODS
The subjects adhered to strict breakfast times starting 2 weeks before the study. Blood was drawn hourly from 0530 or 0630 until 1130. Plasma ghrelin, leptin, and insulin levels were measured by radioimmunoassay.


METHODS
Medical Research Institute, Pusan National University Hospital, Korea.


METHODS
A total of 16 healthy volunteers.


RESULTS
The mean plasma ghrelin level in subjects consuming breakfast was 548.7 +/- 239.6 fmol/ml before breakfast and 384.8 +/- 168.7 fmol/ml 1 h after breakfast, with leptin levels of 6.8 +/- 2.6 and 6.5 +/- 2.5 ng/ml, respectively. Plasma ghrelin levels were lowest 1 h after the meal, although the breakfast times differed. The plasma ghrelin level was lowest at 0730 in subjects not eating breakfast.


CONCLUSIONS
These findings suggest that the plasma ghrelin levels are lowest 1 h after breakfast despite the variance in breakfast times. This timing might best reflect an individual's plasma ghrelin level and enable reasonable comparisons.
Kim
H-H
HH
Department of Laboratory Medicine, College of Medicine, Pusan National University, Busan, South Korea.
Lee
S
S
Jeon
T-Y
TY
Son
H-C
HC
Kim
Y-J
YJ
Sim
M-S
MS
D000328:Adult; D015992:Body Mass Index; D004435:Eating; D005260:Female; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000097:blood*; D007723:Korea; D020738:Leptin / Q000097:blood*; D008297:Male; D036361:Peptide Hormones / Q000097:blood*; D019518:Postprandial Period / Q000502:physiology*; D013997:Time Factors
D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D036361:Peptide Hormones