[Effects of yishenjiangyafang on blood pressure and protecting renal function in RPH rats].
OBJECTIVE
To study the effects and mechanism of Yishenjiangyafang, a prescription of Chinese traditional herbs used for renal hypertension, on blood pressure and protecting renal function of RPH rats.


METHODS
The 5/6 kidney of rat was resected to set up the RPH rat model. Blood pressure, Cr(creatinine), Ccr(creatinine clearance) and BUN(urea nitrogen) were measured dynamically. After eight weeks treatment, plasma content of PAR A II TXB2, 6-keto-PGF1 were measured. At same time, The change of renal pathology was observed.


RESULTS
Yishenjiangyafang could reduce blood pressure Cr, but had no effect on BUN of RPH rat. The indexes of PAR, A II of each different dosage group of Yishenjiangyafang were decreased. At the same time, it reduced plasma content of TXB2, and increased 6-keto-PGF1 alpha. Glomerulosclerosis and atrophy of renal tubule in Yishenjiangyafang group RPH rats were better than those of the contrast group and the Capten group.


CONCLUSIONS
Yishenjiangyafang can reduce blood pressure of RPH rats and has protective effects on its kidney. Yishenjiangyafang can perform its effects of reducing blood pressure and protecting kidney by influencing the RAS of RPH rats.
Chen
Meng-li
ML
Department of Clinical Pharmacology, General Hospital of Chinese PLA, Beijing 100853, China.
Liu
Wen-jun
WJ
Wang
Cai-yun
CY
Zhu
Xiu-mei
XM
Yin
Jian-fen
JF
Wang
Dong-xiao
DX
Liu
Ping
P
D029971:Angelica sinensis / Q000737:chemistry; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D027885:Astragalus propinquus / Q000737:chemistry; D001794:Blood Pressure / Q000187:drug effects*; D001806:Blood Urea Nitrogen; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D006977:Hypertension, Renal / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000473:pathology; D008297:Male; D029596:Paeonia / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal