title: Regional outbreak of mumps due to genotype H in Korea in 1999.
abstract: Serological and virological studies were carried out of a mumps outbreak which occurred in one region, Yoeju County, Southeast of Seoul in Korea from September to December, 1999. Sera from 736 children at 8-13 years of age of patients with mumps and healthy children were tested for mumps-specific antibodies by enzyme immunoassay. The overall IgM positive rate was 7.6% (56/736), compared with 69.8% (514/736) for IgG. Of the 49 children with both IgG and IgM, 32 were also confirmed by both clinical and serological diagnosis. IgM antibodies were detected even in the samples collected up to 3 months after the onset of symptoms. Although 436 children had been vaccinated before the outbreak, 27 (6.2%) were found to be IgM positive, particularly 6 (4.4%) of 136 were positive serologically despite a second-dose vaccinees. Sequence analysis of the small hydrophobic (SH) gene of 4 mumps viruses isolated from 42 saliva specimens revealed that these were related to the genotype H, but distinguishable from European strains. This is the first study on the outbreak due to mumps virus genotype H and provides information to assess the understanding of recent outbreaks of mumps in Korea.
authors.affiliation: Laboratory of Respiratory Viruses, Department of Virology, National Institute of Health, Seoul, Korea.
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Byoung-Kuk
authors.initials: BK
authors.lastname: Na
authors.forename: Jee-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Jin-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Park
authors.forename: Gu-Choul
authors.initials: GC
authors.lastname: Shin
authors.forename: Hae-Wol
authors.initials: HW
authors.lastname: Cho
authors.forename: Ho-Dong
authors.initials: HD
authors.lastname: Lee
authors.forename: Un-Yeong
authors.initials: UY
authors.lastname: Gou
authors.forename: Byoung-Kuk
authors.initials: BK
authors.lastname: Yang
authors.forename: Joon
authors.initials: J
authors.lastname: Kim
authors.forename: Chun
authors.initials: C
authors.lastname: Kang
authors.forename: Woo-Joo
authors.initials: WJ
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D002648:Child; D004196:Disease Outbreaks; D005260:Female; D005814:Genes, Viral; D005838:Genotype; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007723:Korea / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D009107:Mumps / Q000453:epidemiology* / Q000276:immunology / Q000821:virology*; D009109:Mumps virus / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014764:Viral Proteins; C067386:small hydrophobic protein, Mumps virus