title: Linkage analysis of susceptibility to leprosy type using an IBD regression method.
abstract: Leprosy is a chronic disease caused by infection with Mycobacterium leprae, which is manifested across a wide clinical spectrum. There is evidence that susceptibility both to leprosy per se and to the clinical type of leprosy is influenced by host genetic factors. This paper describes the application of an identity by descent regression search for genetic determinants of leprosy type among families from Karonga District, Northern Malawi. Suggestive evidence was found for linkage to leprosy type on chr 21q22 (P<0.001). The methodological implications of the approach and the findings are discussed.
authors.affiliation: London School of Hygiene and Tropical Medicine, UK. c.wallace@qmul.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Wallace
authors.forename: J
authors.initials: J
authors.lastname: Fitness
authors.forename: B
authors.initials: B
authors.lastname: Hennig
authors.forename: L
authors.initials: L
authors.lastname: Sichali
authors.forename: L
authors.initials: L
authors.lastname: Mwaungulu
authors.forename: J M
authors.initials: JM
authors.lastname: Pönnighaus
authors.forename: D K
authors.initials: DK
authors.lastname: Warndorff
authors.forename: D
authors.initials: D
authors.lastname: Clayton
authors.forename: P E M
authors.initials: PE
authors.lastname: Fine
authors.forename: A V S
authors.initials: AV
authors.lastname: Hill
mesh_terms: D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007918:Leprosy / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D008295:Malawi / Q000453:epidemiology; D008297:Male; D010375:Pedigree; D012044:Regression Analysis