title: Effects of ketanserin on hypergranulation tissue formation, infection, and healing of equine lower limb wounds.
abstract: The objective of this multicentre, randomized, controlled field study was to determine the efficacy of ketanserin gel in preventing exuberant granulation tissue formation (hypergranulation) and infection in equine lower limb wounds. Horses and ponies (n = 481) with naturally occurring wounds were randomized to either topical treatment with ketanserin gel (n = 242) or a positive control (Belgium, Germany: ethacridin lactate solution, n = 120; France, United Kingdom: malic, benzoic, and salicylic acid [MBS] cream, n = 119). Treatment continued until the wound healed (success), formed hypergranulation tissue (failure), or became infected (failure). Treatment was terminated after 6 months in all remaining animals. Ketanserin was successful in 88% of cases. Wounds treated with ketanserin were 2 and 5 times more likely to heal successfully than were those treated with MBS or ethacridin lactate, respectively. Ketanserin gel is thus more effective than these standard treatments in preventing hypergranulation tissue and infection of equine lower limb wounds.
authors.affiliation: Janssen Animal Health BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium. mengelen@janbe.jnj.com
authors.forename: Marc
authors.initials: M
authors.lastname: Engelen
authors.forename: Béatrice
authors.initials: B
authors.lastname: Besche
authors.forename: Marie-Paul
authors.initials: MP
authors.lastname: Lefay
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hare
authors.forename: Kathleen
authors.initials: K
authors.lastname: Vlaminck
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005260:Female; D005782:Gels; D006097:Granulation Tissue / Q000187:drug effects* / Q000473:pathology; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses / Q000293:injuries*; D017053:Infection Control; D007650:Ketanserin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D005782:Gels; D010975:Platelet Aggregation Inhibitors; D007650:Ketanserin