title: Comparative analysis of serum homocysteine, folic acid and Vitamin B12 levels in patients with noise-induced hearing loss.
abstract: OBJECTIVE
  The aim of the present study was to determine the levels of homocysteine, folic acid, and Vitamin B12 in subjects with noise-induced hearing loss. Furthermore, possible links between these parameters and noise-induced hearing loss were aimed to be evaluated.
  
  
  METHODS
  In the present study, blood samples were obtained from all subjects after overnight fasting for biochemical analysis. We examined the levels of homocysteine, Vitamin B12 and folic acid levels in subjects with noise-induced hearing loss. Twenty-eight male patients with noise-induced hearing loss (mean age 37 +/- 5 year) were included in the study group whereas the control group was composed of 32 healthy male volunteers (mean age 36 +/- 4 year).
  
  
  RESULTS
  It was found that homocysteine levels of subjects with noise-induced hearing loss as significantly high compared to healthy controls (P < 0.05). On the other hand, Vitamin B12 and folic acid levels of patients with noise-induced hearing loss were determined to be significantly low compared to the controls (P < 0.05 and < 0.01, respectively).
  
  
  CONCLUSIONS
  Our findings indicate that there might be a link between increased homocysteine levels and noise-induced hearing loss. Since increased homocysteine levels cause elevated levels of free radicals in addition to its atherogenic and thrombogenic effects. Further experimental studies are needed to decipher how this relationship is linked.
authors.affiliation: Department of Otorhinolaryngology, College of Medicine, Firat University, Elazig 23119, Turkey. uzeyirgok@yahoo.com
authors.forename: Uzeyir
authors.initials: U
authors.lastname: Gok
authors.forename: Ihsan
authors.initials: I
authors.lastname: Halifeoglu
authors.forename: Halit
authors.initials: H
authors.lastname: Canatan
authors.forename: Mucahit
authors.initials: M
authors.lastname: Yildiz
authors.forename: M Ferit
authors.initials: MF
authors.lastname: Gursu
authors.forename: Biray
authors.initials: B
authors.lastname: Gur
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D005492:Folic Acid / Q000097:blood*; D006317:Hearing Loss, Noise-Induced / Q000097:blood / Q000209:etiology*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires; D014805:Vitamin B 12 / Q000097:blood*
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12