Alpha 2-adrenergic receptor inhibition of cAMP accumulation is transformed to facilitation by tumor necrosis factor-alpha.
Activation of the alpha(2)-adrenergic receptor on neurons regulates the activity of neurons. Inhibition of forskolin-stimulated cAMP accumulation induced by alpha(2)-adrenergic receptor activation is altered following exposure of the neuron SH-SY5Y cell line to tumor necrosis factor-alpha (TNF). Acute (5 and 15 min) exposure to TNF induces a transformation in alpha(2)-adrenergic regulation of cAMP accumulation from inhibition to facilitation. These findings support an autocrine role for the regulation of TNF production from neurons.
Renauld
Amy E
AE
Department of Pathology and Anatomical Sciences, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 206 Farber Hall, 3435 Main Street, Buffalo, NY 14214, USA.
Ignatowski
Tracey A
TA
Spengler
Robert N
RN
D045744:Cell Line, Tumor; D000242:Cyclic AMP / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D018341:Receptors, Adrenergic, alpha-2; D014409:Tumor Necrosis Factor-alpha; D000242:Cyclic AMP