Choroidal neovascularization.
OBJECTIVE
To review clinicopathologic findings of choroidal neovascularization (CNV) in a historical framework with emphasis on pathobiology and correlation with treatment.


METHODS
Selective literature review combined with authors' experience.


RESULTS
Choroidal neovascularization represents a stereotypic, nonspecific response to a specific stimulus. Although CNV differs among patients, the general growth patterns are subretinal pigment epithelium (type 1), subretinal (type 2), or combined. Choroidal neovascularization occurs over time in dynamic stages of initiation, active and involutional. Treatments are now being designed based on modern understanding of CNV growth.


CONCLUSIONS
Progress continues to be made concerning understanding the pathobiology and treatment of CNV.
Grossniklaus
Hans E
HE
Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Green
W Richard
WR
D020256:Choroidal Neovascularization / Q000473:pathology / Q000628:therapy; D006801:Humans