No-D NMR (no-deuterium proton NMR) spectroscopy: a simple yet powerful method for analyzing reaction and reagent solutions.
[reaction: see text] The title technique is a convenient and powerful method for directly monitoring or assaying any reaction mixture or reagent solution. Examples of some common processes (Fischer esterification, lithiation, butyllithium/THF compatibility, olefin metathesis, and a quantification assay), each interrogated in its native solvent, are presented. The spectral data are easy to acquire, and the information content makes a compelling case for routine use of No-D NMR spectroscopy.
Hoye
Thomas R
TR
Department of Chemistry, University of Minnesota, 207 Pleasant St., SE, Minneapolis, Minnesota 55455, USA. hoye@chem.umn.edu
Eklov
Brian M
BM
Ryba
Troy D
TD
Voloshin
Mikhail
M
Yao
Letitia J
LJ
D003903:Deuterium; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons; D012996:Solutions
D007202:Indicators and Reagents; D011522:Protons; D012996:Solutions; D003903:Deuterium