[Peptic ulcer recurrence after successful eradication of Helicobacter pylori--clinical characteristics and management].
Peptic ulcer recurrence after successful eradication of Helicobacter pylori(H. pylori) is not rare. We evaluated the effect of H. pylori eradication on prevention of gastric ulcer recurrence. Ulcer recurrence had occurred in 20 of 256 H. pylori-eradicated patients, and most of ulcer recurrence were found within 1 year after eradication. NSAIDs and psychological stress, but not sex, smoking habit, drinking habit, and past history of ulcer, seem to be associated with ulcer recurrence. Intractable ulcers after the eradication of H. pylori frequently recurred. Some recurrent ulcers were refractory to treatment with H2-receptor antagonists or proton pump inhibitors. The mechanism(s) by which healed ulcers recur after successful eradication of H. pylori remains unclear.
Watanabe
Toshio
T
Department of Gastroenterology, Osaka City University Graduate School of Medicine.
Higuchi
Kazuhide
K
Tominaga
Kazunari
K
Fujiwara
Yasuhiro
Y
Arakawa
Tetsuo
T
D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology*; D012008:Recurrence