Factor V Leiden and G20210A prothrombin mutation and the risk of subclavian vein thrombosis in patients with breast cancer and a central venous catheter.
BACKGROUND
To analyze the influence of the prothrombotic gene mutation factor V G1691A (factor V Leiden) and prothrombin G20210A on the risk of a first episode of catheter-related deep venous thrombosis (DVT) in a group of patients with breast cancer treated with chemotherapy.


METHODS
Between January 1999 and February 2001, the occurrence of a first symptomatic DVT was investigated in a cohort of 300 consecutive patients with locally advanced or metastatic breast cancer treated at a single institution with fluorouracil-based chemotherapy, administered continuously through a totally implanted access port. A nested case-control study included 25 women (cases) with catheter-related DVT and 50 controls without DVT matched with cases for age, identical chemotherapy, stage of disease and prognostic features. The G1691A factor V and G20210A prothrombin mutation genotypes were analyzed.


RESULTS
Five cases [20%; 95% confidence interval (CI) 9% to 39%)] and two controls (4%; 95% CI 1% to 14%) were heterozygous carriers of G1691A factor V (P = 0.04). The age-adjusted odds ratio for catheter-related DVT was 6.1 (95% CI 1.1-34.3). Only one patient (case) had the G20210A prothrombin gene mutation. Time from start of chemotherapy infusion to DVT was not significantly different between patients with (median 31 days) and without (median 43 days) G1691A factor V mutation (P = 0.6).


CONCLUSIONS
Factor V Leiden carriers with locally advanced or metastatic breast cancer have an increased risk of developing catheter-related DVT during chemotherapy.
Mandalà
M
M
Division of Medical Oncology, European Institute of Oncology, Milan, Italy. mariomandela@tin.it
Curigliano
G
G
Bucciarelli
P
P
Ferretti
G
G
Mannucci
P M
PM
Colleoni
M
M
Ventura
A
A
Peruzzotti
G
G
Severi
G
G
Pelicci
P G
PG
Biffi
R
R
Orsi
F
F
Cinieri
S
S
Goldhirsch
A
A
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy*; D016022:Case-Control Studies; D002404:Catheterization / Q000009:adverse effects*; D015331:Cohort Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D006824:Hybridization, Genetic; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D013350:Subclavian Vein / Q000473:pathology; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics
D015415:Biomarkers; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin