Solid-phase synthesis of 5-biphenyl-2-yl-1H-tetrazoles.
The combinatorial synthesis of novel biphenyl tetrazoles is described. Key steps include the simultaneous biphenyl formation and phenol deallylation under Suzuki cross-coupling conditions as well as the tetrazole ring formation on solid support. A representative library of 20 biphenyl tetrazoles was synthesized.
Kivrakidou
Olga
O
Bayer AG, Bayer Health Care, Pharma Research, Building 460, D-42096 Wuppertal, Germany.
Bräse
Stefan
S
Hülshorst
Frank
F
Griebenow
Nils
N