[Experimental studies on antianimia effect of shengxuesu].
OBJECTIVE
Using animal anemia models to observe the antianemia effect of Shengxuesu, and to afford an experimental basis for preventing and treating anemia.


METHODS
Rat model of iron deficiency induced by denutrition and mouse model of nemorrhagic anemia by blood lefting were established. Indices of hemoglobin(HB), red blood cell count(RBC), hematocrit(HCT), mean corpuscular hemoglobin count(MCHC), serum iron(SI), serum ferritin (SF) and total iron-binding capacity(TIBC) were monitored.


RESULTS
A dosage of Shengxuesu 0.5-2 g.kg-1 was given to the rat model of hypoferric anemia by gavage for 15 days, and to the mouse model of hemorrhagic anemia by gavage for 7 days. The result shows that HB, RBC, HCT, MCHC in blood and iron, ferroprotein in serum were elevated significantly; but total bounding iron in serum was decreased. Meanwhile, diet amount, diet consumption and general activity of the model rats were increased.
Piao
Jin-hua
JH
Pharmacology Department, Shanxi Institute for Drug Control, Taiyuan 030001, Shanxi, China. Marypaio@263.net
Zhang
Li
L
Zhang
Hong
H
Gao
Tian-hong
TH
Li
Xian-hua
XH
D000743:Anemia, Hemolytic / Q000097:blood*; D018798:Anemia, Iron-Deficiency / Q000097:blood*; D000818:Animals; D031174:Atractylodes / Q000737:chemistry; D002214:Capsules; D003670:Deer; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000097:blood; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D008419:Materia Medica; D007501:Iron