Epidemiology of breast cancer among BRCA mutation carriers: an overview.
Mutations in BRCA1 and BRCA2 have been associated with an increased lifetime risk of breast and ovarian cancers. Many of the well-recognized risk factors and risk modifiers in other women appear to operate similarly in BRCA mutation carriers. However, current evidence suggests that BRCA-related breast cancer risk is positively associated with pregnancy and parity, while smoking may reduce the risk. The incidence of BRCA1-related breast cancer is high before the age of 35 years and oral contraceptive use for 5 or more years is associated with increased risk of this disease among women carrying BRCA1 mutations.
Nkondjock
André
A
Epidemiology Research Uit, Research Centre, Centre Hospitalier de l'Université de Montréal-Hôtel-Dieu, Pavillon Masson, Que., Canada.
Ghadirian
Parviz
P
D000328:Adult; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1 / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology; D012307:Risk Factors; D012907:Smoking