Y chromosome microdeletion screening in infertile men in France: a survey of French practice based on 88 IVF centres.
Y chromosome microdeletion screening is advised in cases of severely impaired spermatogenesis. Improvements in molecular biological techniques have made diagnosis more accessible in routine analysis. However, Y chromosome microdeletions are not diagnosed in all IVF centres. The aim of the present study was to determine the regulatory (indications, financing) and performance (methods, invoicing) conditions required for this analysis, in France. Microdeletion detection was found to be spreading fast and consistantly. It therefore seems necessary for a consensus to be reached on indications, with a view to a standardized technique, with a common effort of experts in the field. Financial management by the French Health Insurance bodies (Sécurité Sociale) would be an essential step towards routine adoption. Lastly, the answers to our questionnaire revealed a strong demand for information concerning this analysis.
Aknin-Seifer
Isabelle Esther
IE
Laboratoire de Biologie de la Reproduction, Hôpital Nord, 42055 Saint Etienne, Lyon, France. rachel.levy@chu-st-etienne.fr
Lejeune
Hervé
H
Touraine
Renaud Laurian
RL
Levy
Rachel
R
D000554:Ambulatory Care Facilities; D041322:Chromosomes, Human, Y; D005307:Fertilization in Vitro; D005602:France; D017353:Gene Deletion; D005820:Genetic Testing; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011364:Professional Practice; D011795:Surveys and Questionnaires