Biological studies of radiolabeled glucose analogues iodinated in positions 3, 4 or 6.
The aim of this study was to assess the biological behavior of new radiolabeled glucose analogues proposed as tracers of glucose uptake in vivo and iodinated in position 3, 4, or 6. Biological results obtained in vitro on adipocytes and erythrocytes and in vivo in mice were compared to those obtained with the gold-standard tracer of glucose uptake, 2-deoxy-D-glucose. None of these molecules had the same biological behavior than 2-deoxy-D-glucose. Therefore, these compounds cannot be considered as tracers of glucose uptake.
Perret
Pascale
P
Radiopharmaceutiques Biocliniques, INSERM E03 40, Université Joseph Fourier, 38000 Grenoble, France.
Ghezzi
Catherine
C
Ogier
Lionel
L
Abbadi
Medhi
M
Morin
Christophe
C
Mathieu
Jean-Paul
JP
Fagret
Daniel
D
D017667:Adipocytes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D004912:Erythrocytes / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D005947:Glucose / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose