Reactions in unusual media.
This review provides an introduction to three of the most well-developed solvent replacement strategies currently under investigation for synthetic chemistry: Ionic liquids, fluorous phase techniques, and supercritical carbon dioxide. They are all fascinating reaction media, and have considerable potential for use in pharmaceutical synthesis. However, this has to be balanced with problems and limitations of the new methods. This review aims to provide an overall account of recent advances in the use of unusual media for synthetic chemistry, with an emphasis on highlighting potential benefits, but also limitations, of each of the methods described.
Clarke
Daniel
D
Department of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Ali
Mohammed A
MA
Clifford
Anthony A
AA
Parratt
Andrew
A
Rose
Paul
P
Schwinn
Dominik
D
Bannwarth
Willi
W
Rayner
Christopher M
CM
D002245:Carbon Dioxide / Q000737:chemistry; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry*
D006845:Hydrocarbons, Fluorinated; D007477:Ions; D004364:Pharmaceutical Preparations; D012997:Solvents; D002245:Carbon Dioxide