title: Diastereoselective synthesis of anti-1,2-aminoalcohol by palladium(II) catalyzed aza-Claisen rearrangement.
abstract: In this study, a highly diastereoselective synthesis of anti-1,2-aminoalcohol was explored starting from L-amino acids as chiral sources. The higher yield and diastereoselectivity was shown when the aza-Claisen rearrangement was performed with allylic trichloroacetimidate 6a in the presence of palladium(II) catalyst.
authors.affiliation: College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.
authors.forename: Youn-Jung
authors.initials: YJ
authors.lastname: Yoon
authors.forename: Myung-Hee
authors.initials: MH
authors.lastname: Chun
authors.forename: Jae-Eun
authors.initials: JE
authors.lastname: Joo
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Kim
authors.forename: Chang-Young
authors.initials: CY
authors.lastname: Oh
authors.forename: Kee-Young
authors.initials: KY
authors.lastname: Lee
authors.forename: Yiu-Suk
authors.initials: YS
authors.lastname: Lee
authors.forename: Won-Hun
authors.initials: WH
authors.lastname: Ham
mesh_terms: D000605:Amino Alcohols / Q000138:chemical synthesis*; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D006900:Hydroxylation; D007202:Indicators and Reagents; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000605:Amino Alcohols; D001372:Aza Compounds; D007202:Indicators and Reagents; D010165:Palladium