title: Mutations in ribonuclease L gene do not occur at a greater frequency in patients with familial prostate cancer compared with patients with sporadic prostate cancer.
abstract: Several genetic loci are suspected to be involved in hereditary prostate cancer, including the hereditary prostate cancer 1 (HPC1) locus at chromosome 1q24-25. The ribonuclease L (RNase L) gene has been reported as the putative hereditary prostate cancer gene located at HPC1. If this is the case, mutations of RNase L should be found at a greater frequency in familial cancers than in sporadic prostate cancers. Examination of familial and sporadic cases of prostate cancer by polymerase chain reaction and DNA sequencing resulted in a mutational frequency rate that was not statistically different between the 2 forms of the disease. These results suggest that the mutations examined within this study are rare and may contribute to very few familial prostate cancers.
authors.affiliation: Lank Center for Genitourinary Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Sean R
authors.initials: SR
authors.lastname: Downing
authors.forename: Kristen T
authors.initials: KT
authors.lastname: Hennessy
authors.forename: Miyako
authors.initials: M
authors.lastname: Abe
authors.forename: Judith
authors.initials: J
authors.lastname: Manola
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: George
authors.forename: Philip W
authors.initials: PW
authors.lastname: Kantoff
mesh_terms: D004252:DNA Mutational Analysis; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics*; D012260:Ribonucleases / Q000235:genetics*
chemical_list: D012260:Ribonucleases