A mechanism for the development of subepithelial deposits in a patient with type III membranoproliferative glomerulonephritis.
We report on a patient with membranoproliferative glomerulonephritis (MPGN) type III, whose repeated renal biopsies show evolution from a type I-like pattern to a type III pattern of immune complex formation over a 1-year period. Based on the development of experimental in situ immune complex glomerulonephritis, we discuss possible mechanisms for the formation of subepithelial deposits in type III MPGN with reference to an experimental in situ immune complex model of glomerulonephritis.
Fujigaki
Yoshihide
Y
The First Department of Medicine, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan. yf0516@hama-med.ac.jp
Ohashi
Naro
N
Yonemura
Katsuhiko
K
Fujimoto
Taiki
T
Fukasawa
Hirotaka
H
Togawa
Akashi
A
Suzuki
Hiroyuki
H
Yasuda
Hideo
H
Yamamoto
Tatsuo
T
Hishida
Akira
A
D000328:Adult; D000936:Antigen-Antibody Complex; D002196:Capillaries / Q000473:pathology; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000473:pathology
D000936:Antigen-Antibody Complex