title: P-Chirogenic diaminophosphine oxide: a new class of chiral phosphorus ligands for asymmetric catalysis.
abstract: We successfully synthesized a novel P-chirogenic diaminophosphine oxide 4, which was applied to catalytic enantioselective construction of quaternary carbon centers using Pd-catalyzed asymmetric allylic substitution with various beta-keto esters (up to 99% yield, 94% ee). Preliminary mechanistic studies indicated that two molecules of 8 coordinate to the Pd metal in a monodentate fashion, resulting in the formation of Pd complex 9 (Pd:8 = 1:2), which functions as the active species.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Tetsuhiro
authors.initials: T
authors.lastname: Nemoto
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Takamasa
authors.initials: T
authors.lastname: Masuda
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hitomi
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Hatano
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Hamada