Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer.
BACKGROUND
The macrophage scavenger receptor 1 (MSR1) gene on chromosome 8p22 was recently reported as a candidate gene for hereditary prostate cancer (HPC). Here, we further elucidate the role of MSR1 in both Swedish families with HPC and in a cohort of unselected prostate cancer.


METHODS
DNA samples from 83 Swedish HPC families and 215 unselected population based cases of prostate cancer as well as 425 age-matched controls were genotyped.


RESULTS
A total of 18 variants were identified, including 2 exonic, 7 intronic changes, and 9 changes in the 5'- or 3'-uncoding region. Of the two exonic changes, one previously reported truncation mutation was identified, a R293X nonsense mutation. This mutation was found in 2 of the 83 (2.4%) HPC families. The R293X mutation was found more frequently in men with PC (4.9%) than in unaffected men (2.7%), consistent with previous published results, however our results were not significant (P = 0.16). To additionally test for potential association of common sequence variants and increased risk for the disease, five common polymorphisms (PRO3, INDEL1, IVS5-57, P275A, INDEL7) were genotyped in the group of 215 prostate cancer cases and 425 age-matched controls. No association between any of the five common sequence variants and prostate cancer were found.


CONCLUSIONS
Our results suggest that mutations in MSR1 gene might play a role in prostate cancer susceptibility, particularly the R293X mutation. This study warrants further investigations of the role of MSR1 in prostate cancer etiology.
Lindmark
Fredrik
F
Department of Radiation Sciences, Oncology, University of Umeå, Umeå, Sweden.
Jonsson
Björn-Anders
BA
Bergh
Anders
A
Stattin
Pär
P
Zheng
S Lilly
SL
Meyers
Deborah A
DA
Xu
Jianfeng
J
Grönberg
Henrik
H
D000368:Aged; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004247:DNA / Q000032:analysis; D004252:DNA Mutational Analysis; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D051116:Receptors, Scavenger; D012307:Risk Factors; D051117:Scavenger Receptors, Class A; D013548:Sweden
D015815:Cell Adhesion Molecules; C495139:MSR1 protein, human; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D004247:DNA