A prospective trial of steroid withdrawal after renal transplantation in children: results obtained 1990 and 2002.
Ten-year graft survival rate was 89% after immunosuppressive therapy with cyclosporine, methylprednisolone, and mizoribine in pediatric renal transplant recipients enrolled in our multicenter study. Adrenocorticosteroids, which cause growth retardation, were reduced by administration on alternate days in 67% and withdrawn in 23% of recipients. Acute rejection episodes occurred in 30% of patients after withdrawal of steroids. Graft function returned to prerejection levels after treatment with high-dose methylprednisolone. Catch-up growth occurred after alternate day administration and steroid withdrawal. Twenty-eight of 94 patients reached the final height of 156 cm in boys and 145 cm in girls, because of the gradually reduced growth rate. Management of growth retardation before transplantation, especially in patients with congenital renal diseases, and early reduction of the steroid dose after transplantation will increase the final height of children with chronic renal failure.
Hasegawa
A
A
Department of Nephrology, Toho University School of Medicine, Tokyo, Japan. akirah@med.toho-u.ac.jp
Motoyama
O
O
Shishido
S
S
Ito
K
K
Tsuzuki
K
K
Takahashi
K
K
Ohshima
S
S
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001827:Body Height / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007223:Infant; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D011446:Prospective Studies; D012263:Ribonucleosides / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D012263:Ribonucleosides; C010052:mizoribine; D016572:Cyclosporine; D008775:Methylprednisolone