[Treatment of Duchenne muscular dystrophy with gentamicin].
This article reviews the clinical application of gentamicin treatment for nonsense mutations. Since gentamicin is applied only for Duchenne muscular dystrophy caused by a nonsense mutation, genetic diagnosis of DMD is reviewed. Of the two reports describing gentamicin treatment of DMD, one concluded it to be effective, and the other to be ineffective.
Matsuo
Masafumi
M
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Hyogo. matsuo@kobe-u.ac.jp
Takeshima
Yasuhiro
Y
Yagi
Mariko
M
Ishibashi
Kazuto
K
Wada
Hiroko
H
D000818:Animals; D018389:Codon, Nonsense; D016189:Dystrophin / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D025202:Molecular Diagnostic Techniques; D020388:Muscular Dystrophy, Duchenne / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics
D018389:Codon, Nonsense; D016189:Dystrophin; D005839:Gentamicins