title: Willingness to donate blood samples for genetic research: a survey from a community in Singapore.
abstract: Studies on the public's willingness to donate blood specimens for genetic research are few and are conducted mainly among Western countries. Little is known about the Asian community's willingness to participate in genetic research. A community-based survey was conducted on 548 adult Singaporeans to examine their willingness to donate blood samples for genetic research and its associated factors. The response rate was 70.3%. About 49.3% (95% CI, 45.1-53.5%) were willing to donate blood for genetic research. In the multivariable Cox regression analysis, willingness was significantly associated with belief in the benefits of genetic research; intention to participate in government studies; having no fear of pain, blood, injections, and needles; and non-concern about the loss of confidentiality. Reasons against donating blood were fear of pain, blood, injections, and needles (38.1%); no self-benefits (24.8%); fear of finding out about having a disease (22.3%); fear of discrimination (18.7%); and concerns about weakness (15.1%) and weight gain (9.4%). Public education programs to promote participation in genetic research should stress its benefits and address people's fears and concerns.
authors.affiliation: Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore.
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: K S
authors.initials: KS
authors.lastname: Chia
authors.forename: W M
authors.initials: WM
authors.lastname: Yam
authors.forename: G R
authors.initials: GR
authors.lastname: Teodoro
authors.forename: K W
authors.initials: KW
authors.lastname: Lau
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001290:Attitude; D035843:Biomedical Research; D001782:Blood Donors; D003466:Cultural Characteristics; D005260:Female; D005820:Genetic Testing; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010353:Patient Education as Topic; D011639:Public Opinion; D045808:Refusal to Participate / Q000208:ethnology*; D012846:Singapore / Q000208:ethnology