title: [Effects of yixintong on regulating cellular calcium channels].
abstract: OBJECTIVE
  To explore the protecting mechanism of Yixintong for heart ischemia-reperfusion injury at cellular and subcellular levels, by observing the effects of Yixintong on three kinds of calcium channels.
  
  
  METHODS
  The effects of Yixintong on Ca2+ influx on leak calcium channel, receptor-operationg calcium channel (ROC) and pulse-dependent calcium channel (PDC) were observed respectively, by using rat aortic smooth muscle cell and radioactive 45Ca technique.
  
  
  RESULTS
  Yixintong has no effects on leak calcium channel, but can inhibit the Ca2+ influx in ROC and PDC significantly.
  
  
  CONCLUSIONS
  Yixintong can inhibit the Ca2+ influx in slow channel in a dose-dependent manner.
authors.affiliation: First Hosptal of Chongqing Medicine University, Chongqing 400016, China. lsicheng@yahoo.com
authors.forename: Si-cheng
authors.initials: SC
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Huang
authors.forename: Fei-ming
authors.initials: FM
authors.lastname: Zheng
authors.forename: De-liang
authors.initials: DL
authors.lastname: Wen
authors.forename: Shang-wu
authors.initials: SW
authors.lastname: Mo
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology; D015220:Calcium Channels / Q000187:drug effects*; D027825:Crataegus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015220:Calcium Channels; D004365:Drugs, Chinese Herbal; D005419:Flavonoids