[Studies on stability of chlorogenic acid in extract of Flos lonicerae].
OBJECTIVE
To investigate the stability of chlorogenic acid in extract of flos lonicerae in different conditions.


METHODS
The stability of chlorogenic acid in extract of flos lonicerae in phosptat buffe with different pH values, methanol, ethanol and different base solutions(Ca(OH)2 and NaOH) was investigated by the classical isothermal method.


RESULTS
The experiments showed the chlorogenic acid in extract of flos lonicerae was more stable in acidic water than in basic water. It was stable in these organic solutions and base solution[Ca(OH)2].


CONCLUSIONS
In different conditions, the stability of chlorogenic acid in extract of flos lonicerae was different. It provided a reference to the extraction and analysis of chlorogenic acid and production of chlorogenic acid preparation.
Chen
Gang
G
Pharmaceutical Laboratory of Chinese Materia Medica, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
Hou
Shi-xiang
SX
Hu
Ping
P
He
Ning
N
Zhu
Ya-ning
YN
Cao
Lun
L
D002126:Calcium Hydroxide; D002726:Chlorogenic Acid / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D035264:Flowers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D031239:Lonicera / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012972:Sodium Hydroxide; D012996:Solutions; D013678:Technology, Pharmaceutical / Q000379:methods
D012996:Solutions; D002726:Chlorogenic Acid; D012972:Sodium Hydroxide; D002126:Calcium Hydroxide