title: Synthesis of a novel intercalator based on 2,2'-binaphthalene bearing dimethylammonium groups.
abstract: A novel type of DNA intercalator, 8,8'-bis(dimethylaminomethyl)-2,2'-binaphthalene (1) based on 2,2'-binaphthalene skeleton, was prepared via homocoupling of 7-bromo-1-methylnaphthalene as a key step. The binding ability of 1 for calf thymus (CT) DNA was evaluated by UV-vis and fluorescence spectroscopic titrations and the melting temperature of CT DNA. The apparent association constant of 1 with CT DNA was larger than that of ethidium bromide (EB).
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu, Gunma 376-8515, Japan. kondo@chem.gunma-u.ac.jp
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Kondo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kinjo
authors.forename: Yumihiko
authors.initials: Y
authors.lastname: Yano
mesh_terms: D007364:Intercalating Agents / Q000138:chemical synthesis*; D009281:Naphthalenes / Q000138:chemical synthesis*; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis*
chemical_list: D007364:Intercalating Agents; D009281:Naphthalenes; D000644:Quaternary Ammonium Compounds; C412331:2,2'-binaphthyl