title: Use of desferoxamine and S-adenosylmethionine to treat hemochromatosis in a red ruffed lemur (Varecia variegata ruber).
abstract: Hemochromatosis was diagnosed in a 14-year-old, male, red ruffed lemur (Varecia variegata ruber) on the basis of abnormal results of serum biochemical analysis, including high serum ferritin and transferrin saturation values, and of liver biopsy. Therapy included chelation, using desferoxamine to remove excess iron and S-adenosylmethionine to improve liver function, and monthly peripheral blood removal by phlebotomy to reduce total body iron content. Response to treatment was assessed by changes in the lemur's attitude and appetite, as well as variations in serum biochemical and iron panel values. Initial improvement was associated with the onset of therapy. After 56 days of treatment, results of serum biochemical analysis indicated a decrease in iron panel values. Treatment was temporarily discontinued from days 56 to 65, and the lemur's condition worsened, so therapy was re-instituted. However, the lemur died of hepatocellular carcinoma on day 110 of treatment.
authors.affiliation: Smithsonian National Zoological Park, 3001 Connecticut Avenue, North West, Washington, DC 20008-2598, USA.
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Sanchez
authors.forename: Suzan
authors.initials: S
authors.lastname: Murray
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Montali
mesh_terms: D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D003131:Combined Modality Therapy; D003676:Deferoxamine / Q000627:therapeutic use*; D017809:Fatal Outcome; D006403:Hematologic Tests / Q000662:veterinary; D006432:Hemochromatosis / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D007501:Iron / Q000097:blood; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D007900:Lemur; D008099:Liver / Q000473:pathology; D008297:Male; D018962:Phlebotomy / Q000662:veterinary; D018419:Primate Diseases / Q000473:pathology / Q000628:therapy*; D012016:Reference Values; D012436:S-Adenosylmethionine / Q000627:therapeutic use*
chemical_list: D007502:Iron Chelating Agents; D012436:S-Adenosylmethionine; D007501:Iron; D003676:Deferoxamine