Healthcare worker seroconversion in SARS outbreak.
Serum samples were obtained from healthcare workers 5 weeks after exposure to an outbreak of severe acute respiratory syndrome (SARS). A sensitive dot blot enzyme-linked immunosorbent assay, complemented by a specific neutralization test, shows that only persons in whom probable SARS was diagnosed had specific antibodies and suggests that subclinical SARS is not an important feature of the disease.
Chow
Pierce K H
PK
Department of General Surgery, Singapore General Hospital, Singapore. gsupc@singnet.com.sg
Ooi
Eng-Eong
EE
Tan
Hiang-Khoon
HK
Ong
Kong-Wee
KW
Sil
Bijon Kumar
BK
Teo
Melissa
M
Ng
Timothy
T
Soo
Khee-Chee
KC
D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D006282:Health Personnel; D009500:Neutralization Tests; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology; D016036:Seroepidemiologic Studies; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology*; D012846:Singapore / Q000453:epidemiology
D000914:Antibodies, Viral