title: Venous thrombosis: prevalence of prothrombotic defects in north Indian population.
abstract: 431 patients with thrombosis of different venous system were evaluated for underlying acquired and inherited prothrombotic states. Associated acquired risk factors were observed to be present in 28.7% patients and possible inherited in 32.3%, in the rest, no cause could be identified. Major acquired risk factors included coexistence of liver disease (12.2%), oral contraceptives (4.1%), puerperium (2.5%), malignancy (2.3%) and lupus anticoagulant (2%). Low levels of protein C were detected in 21.1% and of which 11.3% were attributed to acquired factors. Protein S deficiency was found in 19.0% and of these 10.4% cases were associated with acquired risk factors. Antithrombin III (AT III) deficiency was detected in 6.4% of patients, of which 4.8% were secondary to acquired factors. In the rest, deficiency of protein C, protein S and AT III were attributed to inherited factors as no associated acquired risk factor was present. Activated protein C resistance (APC-R) was present in 12.5% cases.
authors.affiliation: Department of Hematology, All India Institute of Medical Sciences, New Delhi.
authors.forename: Maitreyee
authors.initials: M
authors.lastname: Bhattacharyya
authors.forename: M
authors.initials: M
authors.lastname: Kannan
authors.forename: V P
authors.initials: VP
authors.lastname: Chaudhry
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020152:Antithrombin III Deficiency / Q000150:complications; D002648:Child; D003276:Contraceptives, Oral / Q000009:adverse effects; D005260:Female; D006801:Humans; D007194:India; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D020151:Protein C Deficiency / Q000150:complications; D018455:Protein S Deficiency / Q000150:complications; D012307:Risk Factors; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology* / Q000235:genetics
chemical_list: D003276:Contraceptives, Oral