title: Tumour T-lymphocyte subset infiltration and tumour recurrence following curative resection for colorectal cancer.
abstract: OBJECTIVE
  The relationship of tumour T-lymphocytic subset infiltration and recurrence in patients undergoing potentially curative resection for colorectal cancer has not been clearly defined.
  
  
  METHODS
  Tumour sections from patients who had undergone potentially curative resection for colorectal cancer were stained and counted for CD4+ and CD8+ T-lymphocytes.
  
  
  RESULTS
  Twenty-three patients developed recurrence during the follow-up period. Patients were grouped according to whether or not they developed recurrence. The groups were similar in age, sex, site of tumour, Dukes stage and the numbers of patients receiving adjuvant therapy. The total percentage volume of labelled CD4+ T-lymphocytes in the tumour was significantly lower in the patients who recurred (p<0.05).
  
  
  CONCLUSIONS
  The results of the present pilot study suggest that a reduction in tumour T-lymphocyte infiltration, in particular CD4+ T-lymphocyte infiltration, is associated with recurrence in patients following potentially curative resection for colorectal cancer.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, Scotland G31 2ER, UK.
authors.forename: A A
authors.initials: AA
authors.lastname: Ali
authors.forename: D C
authors.initials: DC
authors.lastname: McMillan
authors.forename: I I
authors.initials: II
authors.lastname: Matalka
authors.forename: A M
authors.initials: AM
authors.lastname: McNicol
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D003082:Colectomy; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000276:immunology*; D009367:Neoplasm Staging; D010865:Pilot Projects; D016176:T-Lymphocyte Subsets / Q000276:immunology*