title: [Treatment of Duchenne muscular dystrophy with gentamicin].
abstract: This article reviews the clinical application of gentamicin treatment for nonsense mutations. Since gentamicin is applied only for Duchenne muscular dystrophy caused by a nonsense mutation, genetic diagnosis of DMD is reviewed. Of the two reports describing gentamicin treatment of DMD, one concluded it to be effective, and the other to be ineffective.
authors.affiliation: Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Hyogo. matsuo@kobe-u.ac.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Matsuo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeshima
authors.forename: Mariko
authors.initials: M
authors.lastname: Yagi
authors.forename: Kazuto
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Wada
mesh_terms: D000818:Animals; D018389:Codon, Nonsense; D016189:Dystrophin / Q000235:genetics; D005839:Gentamicins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D025202:Molecular Diagnostic Techniques; D020388:Muscular Dystrophy, Duchenne / Q000175:diagnosis* / Q000188:drug therapy* / Q000235:genetics
chemical_list: D018389:Codon, Nonsense; D016189:Dystrophin; D005839:Gentamicins