[Effects of aminoguanidine on the expression of NOS in facial nerve and surrounding tissues of traumatic facial paralysis rats].
OBJECTIVE
To study the effects of inducible NOS inhibitor aminoguanidine on the expression of NOS in facial nerve and surrounding tissue of traumatic facial paralysis rats.


METHODS
A small dose of aminoguanidine were intraperitoneally injected into rats before and after facial paralysis. The facial nerve and surrounding tissues were cut at different time point. Immunohistochemical ABC method was used to study the changes of NOS expression in facial nerve and surrounding tissues.


RESULTS
The inducible NOS immunoreactivity was obvious inhibited in the facial nerve and surrounding tissues in aminoguanidine group.


CONCLUSIONS
Aminoguanidine chronic treatment can obvious inhibit the inducible NOS expression in the facial nerve and surrounding tissues. Aminoguanidine can improve the regeneration of facial nerve and the recovery of traumatic tissues.
Wang
Li-jun
LJ
Dept. of Stomatology, General Hospital of Chinese, People's Armed Police Forces, Beijing 100039, China.
Zhou
Shu-xia
SX
Gu
Xiao-ming
XM
Zhang
Ying
Y
D000818:Animals; D005154:Facial Nerve / Q000201:enzymology*; D020220:Facial Nerve Injuries / Q000201:enzymology*; D005158:Facial Paralysis / Q000201:enzymology*; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000201:enzymology; D009416:Nerve Regeneration; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D006146:Guanidines; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; C004479:pimagedine