title: Phytochemical constituents of the aerial parts from Solidago virga-aurea var. gigantea.
abstract: The chromatographic separation of the MeOH extract of the aerial parts of Solidago virga-aurea var. gigantea M(IQ) (Compositae) led to the isolation of six terpenoids and four phenolic compounds, trans-phytol (1), ent-germacra-4(15),5,10(14)-trien-1alpha-ol (2), beta-amyrin acetate (3), ent-germacra-4(15),5,10(14)-trien-1beta-ol (4), beta-dictyopterol (5), oleanolic acid (6), kaempferol (7), kaempferol-3-O-rutinoside (8), methyl 3,5-di-O-caffeoyl quinate (9), and 3,5-di-O-caffeoyl quinic acid (10). Their structures were established by chemical and spectroscopic methods. Compounds 4, 5, and 10 showed moderate cytotoxicity against five cultured human tumor cell lines in vitro with its ED50 values ranging from 1.52 to approximately 18.57 microg/mL.
authors.affiliation: Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Kyunggi-Do 440-746, Korea.
authors.forename: Sang Zin
authors.initials: SZ
authors.lastname: Choi
authors.forename: Sang Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Kang Ro
authors.initials: KR
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D036624:Solidago / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D010936:Plant Extracts