Proinflammatory cytokines, immune response and tumour progression.
Tumour cells naturally secrete proinflammatory cytokines and chemokines to interact with the microenvironment and regulate neoangiogenesis. The repertoire of factors thus produced shapes tumour progression. However, experiments in the mouse have shown that injection of a low pharmacological dose of a proinflammatory cytokine or chemokine into the microenvironment increases the inflammatory reaction so enormously that locally activated leukocytes inhibit or eradicate the tumour. Massive shrinkage of recurrent head and neck squamous cell carcinomas (SCC) and prevention of recurrences after surgical removal of a primary SCC follow perilymphatic administration of low doses of interleukin (IL)2, while low daily doses of IL12 markedly delay carcinogenesis in transgenic mice predestined to die of mammary carcinomas and keep them tumour-free for long periods. The reaction elicited by proinflammatory cytokines evidently has a great potential in tumour control.
Spadaro
Michela
M
Department of Clinical and Biological Sciences, University of Torino, Ospedale San Luigi Gonzaga, 10043 Orbassano, Italy.
Forni
Guido
G
D000818:Animals; D016207:Cytokines / Q000276:immunology*; D018450:Disease Progression; D006801:Humans; D007107:Immune System / Q000502:physiology; D007111:Immunity, Cellular; D009369:Neoplasms / Q000276:immunology*
D016207:Cytokines