title: A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed.
authors.affiliation: Cancer Research Institute, National Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Zhao Yang
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Jia Hui
authors.initials: JH
authors.lastname: Xia
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.forename: Shou Rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Xiao Ling
authors.initials: XL
authors.lastname: Li
authors.forename: Dong Xu
authors.initials: DX
authors.lastname: Hu
authors.forename: Chen
authors.initials: C
authors.lastname: Tan
authors.forename: Juan Juan
authors.initials: JJ
authors.lastname: Xiang
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
authors.forename: Song Qing
authors.initials: SQ
authors.lastname: Fan
authors.forename: Wei Fang
authors.initials: WF
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Shi Guo
authors.initials: SG
authors.lastname: Zhu
authors.forename: Hong Bin
authors.initials: HB
authors.lastname: Lü
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
authors.forename: Bi Cheng
authors.initials: BC
authors.lastname: Zhang
authors.forename: Jie Ru
authors.initials: JR
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Bing Yi
authors.initials: BY
authors.lastname: Xiao
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Qiu Hong
authors.initials: QH
authors.lastname: Zhang
authors.forename: Yan Hong
authors.initials: YH
authors.lastname: Zhou
authors.forename: Xiao Min
authors.initials: XM
authors.lastname: Luo
authors.forename: Hou De
authors.initials: HD
authors.lastname: Zhou
authors.forename: Yi Xin
authors.initials: YX
authors.lastname: Yang
authors.forename: He Ping
authors.initials: HP
authors.lastname: Dai
authors.forename: Guo Yin
authors.initials: GY
authors.lastname: Feng
authors.forename: Qian
authors.initials: Q
authors.lastname: Pan
authors.forename: Ling Qian
authors.initials: LQ
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Gui Yuan
authors.initials: GY
authors.lastname: Li
mesh_terms: D002681:China / Q000453:epidemiology; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D005810:Multigene Family; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D010375:Pedigree