title: Arborcandins A, B, C, D, E and F, novel 1,3-beta-glucan synthase inhibitors: physico-chemical properties and structure elucidation.
abstract: Arborcandins A, B, C, D, E and F, which possess potent 1,3-beta-glucan synthase inhibitory activity, were isolated from the cultured broth of a filamentous fungus, strain SANK 17397. The structures of arborcandins A, B, C, D, E and F were elucidated by a combination of NMR and mass spectrometry, and established to be novel cyclic peptides containing uncommon amino acid residues.
authors.affiliation: Lead Discovery Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Ohyamaa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Iwadate-Kurihara
authors.forename: Tomio
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Shunichi
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hamano
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Inukai
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000737:chemistry*; D005964:Glucosyltransferases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D010455:Peptides; D005964:Glucosyltransferases; C020570:1,3-beta-glucan synthase