title: Discovery and SAR of trisubstituted thiazolidinones as CCR4 antagonists.
abstract: Substituted thiazolidinones were identified as CCR4 antagonists from high throughput screening. Subsequent lead optimization efforts resulted in defined structure-activity relationships and the identification of potent antagonists (compounds 90 and 91) that inhibited the chemotaxis of Th2 T-cells in vitro.
authors.affiliation: Array BioPharma, 3200 Walnut Street, Boulder, CO 80301, USA.
authors.forename: Shelley
authors.initials: S
authors.lastname: Allen
authors.forename: Bradley
authors.initials: B
authors.lastname: Newhouse
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Anderson
authors.forename: Benjamin
authors.initials: B
authors.lastname: Fauber
authors.forename: Andrew
authors.initials: A
authors.lastname: Allen
authors.forename: David
authors.initials: D
authors.lastname: Chantry
authors.forename: Christine
authors.initials: C
authors.lastname: Eberhardt
authors.forename: Joshua
authors.initials: J
authors.lastname: Odingo
authors.forename: Laurence E
authors.initials: LE
authors.lastname: Burgess
mesh_terms: D000818:Animals; D051379:Mice; D011485:Protein Binding / Q000502:physiology; D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: C515355:Ccr4 protein, mouse; D054398:Receptors, CCR4; D019707:Receptors, Chemokine; D045162:Thiazolidinediones