title: Cyclodextrin trimers as receptors for arranging ester and catalyst at optimized location to achieve enhancement of hydrolytic activity.
abstract: Two novel trimer receptor molecules (AC and AD trimers) consisting of two alpha-cyclodextrins (alpha-CDs) and one beta-cyclodextrin (beta-CD) have been designed and synthesized in order to make an optimum arrangement between a substrate and a catalyst. In the reaction systems that use trimer receptors as host molecules, the substrate and the catalyst are thought to be accommodated by two alpha-CDs and one beta-CD, respectively. The rate for the hydrolytic reaction of a long-shaped ester was largely increased, when the trimer receptors were used as receptor molecules or molecular flasks, which provided optimum location between the substrate and the catalyst.
authors.affiliation: Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nakajima
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Sakabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ueno
mesh_terms: D002384:Catalysis; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*; D004952:Esters; D006868:Hydrolysis
chemical_list: D003505:Cyclodextrins; D004952:Esters