The zinc finger protein A20 protects endothelial cells from burns serum injury.
Burn injuries as well as skin damages are often associated with immune suppression and often cause multiple organ failures. The monolayer endothelium is vulnerable to injuries from circulating factors resulting from remote wounds. Endothelial cell activation and apoptosis can alter microvascular permeability and intensify organ damage. A20, as a physiological cytoprotective gene is essential for preventing spontaneous innate immune cell-mediated inflammation and tissue destruction. It is not known whether A20 has the function to protect endothelial cells from the effect of burns serum challenge on endothelial function in vitro. This study shows that A20 can express in endothelial cells after burns serum stimulation and inhibit endothelial cell activation and apoptosis induced by burns serum. These results suggest that A20 may be beneficial in limiting the response to burn injuries.
Zhu
Chu-Hong
CH
Department of Anatomy, The Key Lab of Biomechanics under the Ministry, The Third Military Medical University, Gao Tan Yan Street, Shaping Ba District, Chongqing 400038, China.
Ying
Da-Jun
DJ
Mi
Jian-Hong
JH
Zhang
Wei
W
Dong
Shi-Wu
SW
Sun
Jian-Sen
JS
Zhang
Jia-Ping
JP
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D002056:Burns / Q000378:metabolism* / Q000473:pathology; D002417:Cattle; D004268:DNA-Binding Proteins; D019040:E-Selectin / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B / Q000378:metabolism; D009687:Nuclear Proteins; D011506:Proteins / Q000502:physiology*; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors; D014471:Umbilical Veins / Q000378:metabolism; D016335:Zinc Fingers / Q000502:physiology*
D004268:DNA-Binding Proteins; D019040:E-Selectin; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3