title: Applications of the P50 evoked response to the evaluation of cognitive impairments after traumatic brain injury.
abstract: This article reviews the applications of the P50 evoked response to paired auditory stimuli (P50 ERP) in the study and evaluation of cognitive impairments after traumatic brain injury (TBI). The cholinergic hypothesis of cognitive impairment after TBI and the relationship of impaired auditory sensory gating to that hypothesis are presented. The neurobiology of impaired sensory gating, the relationship of that neurobiology to the P50 ERP, and the principles of P50 ERP recording are discussed. Studies of the P50 ERP among patients with persistent cognitive complaints after TBI are reviewed. Finally, possible clinical applications and limitations of the P50 ERP in the study, evaluation, and treatment of patients with cognitive impairments after TBI are offered.
authors.affiliation: Neuropsychiatry Service, Department of Psychiatry, University of Colorado School of Medicine, Campus Box C28-68, 4200 East Ninth Avenue, Denver, CO 80262, USA. David.Arciniegas@UCHSC.edu
authors.forename: David B
authors.initials: DB
authors.lastname: Arciniegas
authors.forename: Jeannie L
authors.initials: JL
authors.lastname: Topkoff
mesh_terms: D000818:Animals; D001288:Attention / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology*; D002799:Cholinergic Fibers / Q000502:physiology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003072:Cognition Disorders / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D008569:Memory Disorders / Q000503:physiopathology; D010830:Physostigmine / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D010830:Physostigmine