title: Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts.
abstract: The aqueous extracts of 24 herbs traditionally used as curing ischemic heart disease in clinic in China were screened for their in vitro angiogenic activity, another twenty-four traditionally used as anti-tumor or anti-inflammatory remedies in China were screened for their in vitro anti-angiogenic activity. The activity of angiogenesis was determined by quantitation of vessels on chick embryo chorioallantoic membrane (CAM) model and cell proliferation of cultured bovine aortic endothelial cells (BAECs). Among the herbal extracts examined, the aqueous extracts of Epimedium sagittatum, Trichosanthes kirilowii and Dalbergia odorifera showed the strong angiogenetic activity both in CAM and BAECs models; and the aqueous extracts of Berberis paraspecta, Catharanthus roseus, Coptis chinensis, Taxus chinensis, Scutellaria baicalensis, Polygonum cuspidatum and Scrophularia ningpoensis elicited significant inhibition at a concentration of 1g dry herb /ml.
authors.affiliation: Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Wang
authors.forename: Zhengui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Yinqi
authors.initials: Y
authors.lastname: Weng
authors.forename: Yijun
authors.initials: Y
authors.lastname: Yu
authors.forename: Daifu
authors.initials: D
authors.lastname: Zhang
authors.forename: Weihu
authors.initials: W
authors.lastname: Fan
authors.forename: Ruihong
authors.initials: R
authors.lastname: Dai
authors.forename: Zhibi
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000482:Allantois / Q000033:anatomy & histology / Q000378:metabolism; D043925:Angiogenesis Inducing Agents / Q000378:metabolism*; D020533:Angiogenesis Inhibitors / Q000378:metabolism*; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D002642:Chick Embryo; D002823:Chorion / Q000033:anatomy & histology / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D010936:Plant Extracts / Q000378:metabolism*
chemical_list: D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D004365:Drugs, Chinese Herbal; D005938:Glucocorticoids; D010936:Plant Extracts; D005346:Fibroblast Growth Factors; D003907:Dexamethasone