[Effect of yirong oral liquid on the reperfusion injury in rats with cerebral infarction undergoing thrombolysis].
OBJECTIVE
To observe the effect of Yirong Oral Liquid (YROL) on reperfusion injury in rats with cerebral infarction undergoing thrombolysis.


METHODS
Clinical reperfusion under thrombolysis was simulated by applying thrombolysis on reversible local cerebral ischemic rat model. In the rat model, effect of YROL on parameters concerning anti-oxidation capability, cerebral edema and ultrastructure of brain were observed.


RESULTS
YROL could alleviate the cerebral edema after reperfusion, markedly increase the activity of superoxide dismutase in blood plasma, decrease the content of malonyldialdehyde, inhibit the post-reperfusion lipid peroxidation, and significantly reduce the ischemia/reperfusion injury of nerve cells in brain of rat.


CONCLUSIONS
YROL has definite protecting effect on brain.
Feng
Xue-gong
XG
Beijing Hospital of the Integrated Traditional and Western Medicine, Beijing 100039.
Liu
Mao-cai
MC
Sun
Jing-bo
JB
D000818:Animals; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018696:Neuroprotective Agents / Q000627:therapeutic use; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood; D015912:Thrombolytic Therapy; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D014568:Urokinase-Type Plasminogen Activator