title: Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection.
abstract: The efficacy of levofloxacin and dirithromycin, alone and in combination with rifampicin in the treatment of experimental brucellosis was investigated. Seventy adult white male mice were infected intraperitoneally with Brucella abortus S544 standard strain. Four of the animals were sacrificed on the 21st day of inoculation for infection control. The remaining 66 mice were randomised into treatment and control groups. Following 14 days of treatment the animals were sacrificed and spleen cultures were made. The cure rates were 36.4% for levofloxacin, 27.3% for dirithromycin, 72.7% for rifampicin, 72.7% for levofloxacin + rifampicin and 81.8% for dirithromycin + rifampicin. The results of this study indicate that levofloxacin and dirithromycin are ineffective in the treatment of experimental murine brucellosis as monotherapy or in combination with rifampicin.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, 35100 Bornova, Izmir, Turkey.
authors.forename: Bilgin
authors.initials: B
authors.lastname: Arda
authors.forename: Mürşide
authors.initials: M
authors.lastname: Tunçel
authors.forename: Tansu
authors.initials: T
authors.lastname: Yaimazhan
authors.forename: Deniz
authors.initials: D
authors.lastname: Gökengin
authors.forename: Ozlem
authors.initials: O
authors.lastname: Gürel
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002003:Brucella abortus; D002006:Brucellosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D064704:Levofloxacin; D008297:Male; D051379:Mice; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; C053853:dirithromycin; D004917:Erythromycin; D064704:Levofloxacin; D015242:Ofloxacin; D012293:Rifampin