Structural identification and characterization of impurities in moxifloxacin.
In the synthesis of Moxifloxacin four prominent impurities were detected in HPLC analysis. These impurities were detected in gradient HPLC method. They were isolated from enriched mother liquors and were characterized as 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(S,S)-N-methyl-2,8-diazabicyclo (4,3,0) non-8yl]-4-oxo-3-quinoline carboxylic acid (Impurity-1), methyl-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(S,S)-2,8-diazabicyclo(4,3,0)non-8-yl]-4-oxo-3-quinoline carboxylate (impurity-2), and 1-cyclopropyl-6-fluoro-1,4 dihydro-8-hydroxy-7-[(S,S)-2,8-diazobicyclo(4,3,0)non-8-yl]-4-oxo-3-quinoline carboxylicacid (impurity-3), 1-cyclopropyl-6,7-difluoro-8-hydroxy-4-oxo-1,4 dihydro-3-quinoline carboxylicacid (impurity-4) by means of 1H, 13C NMR, DEPT, IR and mass spectral data. Structural elucidation by spectral data was discussed.
Kumar
Y Ravindra
YR
Dr. Reddy's Laboratories Ltd., Bulk Actives Unit-III, IDA-Bollaram, Hyderabad, 502325 AP, India.
Prasad Raju
V V N K V
VV
Kumar
R Rajesh
RR
Eswaraiah
S
S
Mukkanti
K
K
Suryanarayana
M V
MV
Reddy
M Satyanarayana
MS
D001372:Aza Compounds / Q000032:analysis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D024841:Fluoroquinolones; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D000077266:Moxifloxacin; D011804:Quinolines / Q000032:analysis* / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin