Orchestrating development and function: retrograde BMP signaling in the Drosophila nervous system.
Recent work has shown that bone morphogenetic protein (BMP) growth factors regulate development of the larval neuromuscular junction (NMJ) of Drosophila. Intriguingly, the same BMP growth factors also influence the expression of circulating hormones that modulate the physiological properties of NMJs. Together, the results suggest that retrograde growth factor signaling by BMPs integrates neuromuscular development and function at both local and global levels in the animal.
Keshishian
Haig
H
Department of Molecular, Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, CT 06520-8103, USA. haig.keshishian@yale.edu
Kim
You-Seung
YS
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology*; D004330:Drosophila; D029721:Drosophila Proteins; D005246:Feedback; D015870:Gene Expression / Q000502:physiology; D008959:Models, Neurological; D009420:Nervous System / Q000254:growth & development*; D009469:Neuromuscular Junction / Q000254:growth & development; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology
D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D009479:Neuropeptides; D016212:Transforming Growth Factor beta; C089440:gbb protein, Drosophila