An efficient synthesis of 3-substituted 3H-pyrimidin-4-ones.
[reaction: see text] A novel and practical synthesis of 3-substituted 3H-pyrimidin-4-ones is described. The key step involves the cyclization of enamide esters, derived from readily available beta-keto esters, with trimethylaluminum and various primary amines.
Jeong
Jae Uk
JU
Department of Medicinal Chemistry, MMPD CEDD, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA. jae.u.jeong@gsk.com
Chen
Xiaohong
X
Rahman
Attiq
A
Yamashita
Dennis S
DS
Luengo
Juan I
JI