Highly diastereoselective synthesis of anti-gamma-N-benzylamino-beta-hydroxyphosphonates.
The reduction of gamma-N-benzylamino-beta-ketophosphonates derived from readily available amino acids can be carried out stereoselectively with Zn(BH(4))(2) at -78 degrees C to produce the anti-gamma-amino-beta-hydroxyphosphonates.
Ordóñez
Mario
M
Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, 62210 Cuernavaca, Mor., Mexico. palacios@buzon.uaem.mx
de la Cruz-Cordero
Ricardo
R
Quiñónes
Citlali
C
González-Morales
Angelina
A
D001596:Benzylamines / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001596:Benzylamines; D009943:Organophosphorus Compounds