[Studies on variation of danshensu content in accelerated stability tests].
OBJECTIVE
To study the variation Laws of content of danshensu accelerated in control and in danshen injection in order to provide reference for stability investigation of danshensu.


METHODS
The tests was carried out by classic isothermal method and the content of danshensu was determined by HPLC.


RESULTS
The contents of danshensu in accelerated tests increase in control and decrease in danshen injection respectively.


CONCLUSIONS
The component of phenic acidity would be hydrolyzed to become danshensu in the accelerated tests. Much attention should be paid to the unusual increase when studies of danshen preparations are carried out.
Mao
Sheng-jun
SJ
Pharmaceutical Laboratory of Chinese Materia Medica, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
Hou
Shi-xiang
SX
Tang
Chang-jiong
CJ
Huang
Xiao-dong
XD
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006868:Hydrolysis; D062385:Hydroxybenzoates / Q000737:chemistry; D007267:Injections; D007773:Lactates / Q000008:administration & dosage / Q000032:analysis* / Q000737:chemistry; D013696:Temperature
D062385:Hydroxybenzoates; D007773:Lactates; C035055:3,4-dihydroxyphenyllactic acid; C017616:phenolic acid