[Effect of shu di-huang on the transmitter and receptor of amino acid in brain and learning and memory of dementia model].
OBJECTIVE
To observe the mechanism of SHU-Dihuang on the function of learning and memory.


METHODS
On the dementia model mouse caused by AlCl3 and the rats model damaged thalamic arcuate nucleus with MSG, we observed the function of learning and memory by step down task and Morris water maze task, mensurated the content of glutamic acid and gamma-aminobutyric acid by TLC, and observed the expression of NMDAR1 and GABAR in hippocampi by immunohistochemical means.


RESULTS
Shu Di Huang could decrease the times of mistakes and prolong the incubation period in step down task, and shorten the incubation period of seeking the platform in Morris water maze task. Shu Di Huang could adjust the content of Glu and GABA in brain, and increase the expression of hippocampal NMDAR1 and GABAR as well.


CONCLUSIONS
Shu Di Huang can improve the function of learning and memory of dementia animal model, and its mechanism may be related to the adjustment of the content of Glu and GABA in brain, and increase of the expression of hippocampal NMDAR1 and GABAR.
Cui
Yng
Y
He Nan College of TCM, Zhengzhou 450008, Henan, China.
Yan
Zheng-hua
ZH
Hou
Shi-liang
SL
Chang
Zhang-fu
ZF
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects; D003704:Dementia / Q000139:chemically induced / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D018079:Receptors, GABA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D032267:Rehmannia / Q000737:chemistry
D004365:Drugs, Chinese Herbal; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; C042579:Liuwei Dihuang Decoction