Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I(1)-receptor action.
IRAS, a putative clone of the I(1)-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the beta(3)-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors.
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Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia. ian.musgrave@adelaide.edu.au
Dehle
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Piletz
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D020816:Amino Acid Motifs; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D054755:Imidazoline Receptors; D016023:Integrins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D016716:PC12 Cells; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D011955:Receptors, Drug / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D002352:Carrier Proteins; D054755:Imidazoline Receptors; D016023:Integrins; D047908:Intracellular Signaling Peptides and Proteins; C458505:NISCH protein, human; D011955:Receptors, Drug; C410887:imidazoline I1 receptors; D020794:Receptor Protein-Tyrosine Kinases