The photocatalytic process as a tool to identify metabolitic products formed from dopant substances: the case of buspirone.
The photocatalytic transformation of buspirone, an analgesic anxiolytic drug, and the formation of intermediates products have been evaluated by adopting titanium dioxide as a photocatalyst. Several molecules resulting from buspirone degradation have been identified and characterized by using HPLC/MS/MS technique. The main intermediates formed in these experimental conditions agree with the major buspirone metabolites found "in vivo" on rats and horses: hydroxy and dihydroxy-buspirone, despyrimidinyl buspirone and 1-pyrimidinyl piperazine. This shows that the photocatalytic system could provide in the present case a useful simulation of the metabolic transformation of dopant substances. Moreover, some more oxidized species have been recognized with the photocatalytic process, and this could offer a suggestion for yet to come metabolism studies.
Calza
Paola
P
Dipartimento di Chimica Analitica, Università di Torino, via P. Giuria 5, 10125 Torino, Italy.
Pazzi
Marco
M
Medana
Claudio
C
Baiocchi
Claudio
C
Pelizzetti
Ezio
E
D014151:Anti-Anxiety Agents / Q000378:metabolism* / Q000528:radiation effects; D002065:Buspirone / Q000378:metabolism* / Q000528:radiation effects; D002384:Catalysis; D002853:Chromatography, Liquid; D013058:Mass Spectrometry; D008954:Models, Biological; D015394:Molecular Structure; D010777:Photochemistry; D014025:Titanium / Q000737:chemistry; D014466:Ultraviolet Rays
D014151:Anti-Anxiety Agents; C009495:titanium dioxide; D014025:Titanium; D002065:Buspirone