title: [Oxygenator thrombosis without heparin resistance].
abstract: A 55-year-old male with a history of positive HIV serology and Polycytemia vera underwent coronary artery bypass graft surgery with normothermic extracorporeal circulation. Following heparin administration the activated clotting time (ACT) was 633 seconds (Hemocron) with kaolin). Lower than expected arterial and venous oxygen partial pressures together with high pressure (350 mmHg) in the arterial line upstream of the oxygenator were observed. Because of these signs the oxygenator was changed during the procedure. The outcome was uneventful. Electronic microscopic examination of the oxygenator membrane and thermic exchanger revealed fibrin and platelet deposits.
authors.affiliation: Service d'anesthésie-réanimation, hôpital Louis-Pradel, BP Lyon-Montchat, 69394 Lyon cedex 03, France. jean.jacques.lehot@chu-lyon.fr
authors.forename: J-J
authors.initials: JJ
authors.lastname: Lehot
authors.forename: B
authors.initials: B
authors.lastname: Waz
authors.forename: L
authors.initials: L
authors.lastname: Dendeleu
authors.forename: P
authors.initials: P
authors.lastname: Gaudon
authors.forename: O
authors.initials: O
authors.lastname: Jegaden
mesh_terms: D004351:Drug Resistance; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D005343:Fibrinolytic Agents; D006493:Heparin