Molecular imaging for pediatric lung diseases.
Molecular imaging is a rapidly developing multidisciplinary field that combines advances in contrast agent development, instrumentation, and molecular/cell biology to follow cellular and sub-cellular events in intact organisms. Platforms for molecular imaging include radionuclide-based methods, optical methods, and magnetic resonance. To date, molecular imaging studies of the lungs have been used to monitor the effectiveness of gene transfer, neutrophilic inflammation, and cell trafficking. Eventually, the goal will be to translate these new techniques to clinical settings such as cystic fibrosis.
Richard
Jean-Christophe
JC
Departments of Internal Medicine, Pediatrics, and Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri 63110, USA.
Chen
Delphine L
DL
Ferkol
Tom
T
Schuster
Daniel P
DP
D003952:Diagnostic Imaging / Q000379:methods*; D019788:Fluorodeoxyglucose F18; D015870:Gene Expression; D017930:Genes, Reporter; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008171:Lung Diseases / Q000175:diagnosis* / Q000235:genetics; D019275:Radiopharmaceuticals
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18