[Hepatitis C virus infection in renal-transplant patients].
Chronic hepatitis C virus (HCV) infection is the first cause of liver disease after renal transplantation. The prevalence of HCV infection in dialysis and in renal-transplant patients remains high. Mortality of HCV-positive renal-transplant patients is higher than that of HCV-negative ones. Liver disease and sepsis seem to be the main causes of death. Graft survival is also lower in HCV-positive renal-transplant patients. This seems to be due in part to the occurrence of de novo glomerulopathy. The effect of HCV infection upon liver fibrosis in renal-transplant patients receiving immunosuppressive treatment remains controversial. To date, there is no efficient treatment of HCV infection after renal transplantation. Consequently, it is mandatory to treat by alpha-interferon all HCV-positive/RNA-positive dialysis patients waiting for renal transplantation.
Kamar
N
N
Service de néphrologie, dialyse et transplantation, CHU Toulouse-Rangueil.
Izopet
J
J
Ribes
D
D
Rostaing
L
L
D000998:Antiviral Agents / Q000627:therapeutic use; D006085:Graft Survival; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology / Q000635:transmission; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation; D008103:Liver Cirrhosis / Q000209:etiology / Q000401:mortality; D017093:Liver Failure / Q000209:etiology / Q000401:mortality; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects; D018805:Sepsis / Q000209:etiology / Q000401:mortality; D009927:Tissue and Organ Procurement / Q000331:legislation & jurisprudence; D014766:Viremia / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology
D000998:Antiviral Agents