A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma.
Nasopharyngeal carcinoma (NPC) poses one of the serious health problems in southern Chinese, with an incidence rate ranging from 15 to 50/100,000. Chromosome translocation t(1;3) and frequent loss of heterogeneity on short arms of chromosome 3 and 9 have been reported to be associated with NPC, and a genome-wide scan identified an NPC susceptibility locus on chromosome 4p15.1-q12 recently. In our study, we collected samples from 18 families at high risk of NPC from the Hunan province in southern China, genotyped with a panel of polymorphic markers on short arms of chromosomes 3, 9, and 4p15.1-q12. A locus on 3p21 was identified to link to NPC with a maximum logarithm of odds for linkage score of 4.18. Fine mapping located the locus to a 13.6-cM region on 3p21.31-21.2, where a tumor suppressor gene cluster resided. Our findings identified a novel locus for NPC and provided a map location for susceptibility genes candidates. In contrast to a recent study, no significant evidence for NPC linkage to chromosomes 4 and 9 was observed.
Xiong
Wei
W
Cancer Research Institute, National Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China.
Zeng
Zhao Yang
ZY
Xia
Jia Hui
JH
Xia
Kun
K
Shen
Shou Rong
SR
Li
Xiao Ling
XL
Hu
Dong Xu
DX
Tan
Chen
C
Xiang
Juan Juan
JJ
Zhou
Jie
J
Deng
Hao
H
Fan
Song Qing
SQ
Li
Wei Fang
WF
Wang
Rong
R
Zhou
Ming
M
Zhu
Shi Guo
SG
Lü
Hong Bin
HB
Qian
Jun
J
Zhang
Bi Cheng
BC
Wang
Jie Ru
JR
Ma
Jian
J
Xiao
Bing Yi
BY
Huang
He
H
Zhang
Qiu Hong
QH
Zhou
Yan Hong
YH
Luo
Xiao Min
XM
Zhou
Hou De
HD
Yang
Yi Xin
YX
Dai
He Ping
HP
Feng
Guo Yin
GY
Pan
Qian
Q
Wu
Ling Qian
LQ
He
Lin
L
Li
Gui Yuan
GY
D002681:China / Q000453:epidemiology; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D005810:Multigene Family; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D010375:Pedigree