title: Myo1c is designed for the adaptation response in the inner ear.
abstract: The molecular motor, Myo1c, a member of the myosin family, is widely expressed in vertebrate tissues. Its presence at strategic places in the stereocilia of the hair cells in the inner ear and studies using transgenic mice expressing a mutant Myo1c that can be selectively inhibited implicate it as the mediator of slow adaptation of mechanoelectrical transduction, which is required for balance. Here, we have studied the structural, mechanical and biochemical properties of Myo1c to gain an insight into how this molecular motor works. Our results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load.
authors.affiliation: Division of Physical Biochemistry, National Institutes for Medical Research, The Ridgeway, Mill Hill, London, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Batters
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Arthur
authors.forename: Abel
authors.initials: A
authors.lastname: Lin
authors.forename: Jessica
authors.initials: J
authors.lastname: Porter
authors.forename: Michael A
authors.initials: MA
authors.lastname: Geeves
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Milligan
authors.forename: Justin E
authors.initials: JE
authors.lastname: Molloy
authors.forename: Lynne M
authors.initials: LM
authors.lastname: Coluccio
mesh_terms: D000220:Adaptation, Biological; D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D020285:Cryoelectron Microscopy; D006198:Hair Cells, Auditory / Q000166:cytology / Q000378:metabolism*; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D051379:Mice; D008958:Models, Molecular; D009218:Myosins / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D013314:Stress, Mechanical
chemical_list: D000244:Adenosine Diphosphate; D009218:Myosins