[The relationship between metoclopramide and hypothalamus-pituitary-thyroid axis and it's clinical application].
TSH secretion is controlled by the stimulatory action of hypothalamic TRH and the inhibition via central dopaminergic and somatostatinergic mechanisms as well as by a hypothalamic inhibitory action of thyroid hormones. Metoclopramide is DA2 receptor blockade which can accelerate to elevate the concentration of serum TSH in hypothyroidism, which is accompanied by a progressive loss of dopaminergic tone as demonstrated by a progressive increase in prolaction serum levels, especially in patients with differentiated thyroid carcinoma(DTC). So the period of L-thyroxine withdrawal is contracted and the symptoms of hypothyroidism is released. It's important to monitor and treat DTC patients with radioactive iodide.
Dai
Qingjing
Q
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.
Kuang
Anren
A
D018492:Dopamine Antagonists / Q000494:pharmacology*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000188:drug therapy; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D007037:Hypothyroidism / Q000097:blood / Q000188:drug therapy; D008787:Metoclopramide / Q000737:chemistry / Q000494:pharmacology*; D013961:Thyroid Gland / Q000187:drug effects / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
D018492:Dopamine Antagonists; D013963:Thyroid Hormones; D013972:Thyrotropin; D008787:Metoclopramide