[Interleukin-5 regulate the bone marrow response in the model of allergic rhinitis].
OBJECTIVE
To elucidate the mechanism of bone marrow response regulated by interleukin-5 (IL-5) in the model of allergic rhinitis.


METHODS
Twenty SD rats were randomly divided into allergic rhinitis (AR) group and control group. The leucocytes in the smears of bone marrow and peripheral blood were counted, and the expression of IL-5 was detected by immunohistochemistry.


RESULTS
The ratio of eosinophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of basophils to white cells in bone marrow smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of eosinophils to white cells in peripheral blood smears of AR group was significantly higher than that of control group(P < 0.01). The ratio of IL-5 positive cells to white cells in bone marrow smears of AR group was significantly higher than that of control group (P < 0.05). The ratio of IL-5 positive cells to white cells was significantly positively correlated with the ratio of eosinophils to white cells in bone marrow smears of AR group (R = 0.85, P < 0.01).


CONCLUSIONS
IL-5 regulates the proliferation and differentiation of eosinophils in bone marrow.
Wang
Xiang-dong
XD
Beijing Tongren Center of Otorhinolaryngology Head-Neck Surgery, Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China. entwxd@vip.sina.com
Han
De-min
DM
Zhou
Bing
B
Wei
Yong-xiang
YX
Bai
Wen-zhong
WZ
Liu
Zhong-yan
ZY
Ju
Shu-ying
SY
D000818:Animals; D001491:Basophils / Q000473:pathology; D001854:Bone Marrow Cells / Q000378:metabolism / Q000473:pathology*; D002452:Cell Count; D004804:Eosinophils / Q000473:pathology; D015848:Interleukin-5 / Q000378:metabolism / Q000502:physiology*; D008297:Male; D010047:Ovalbumin; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*
D015848:Interleukin-5; D010047:Ovalbumin