Poly(D,L-lactide-ran-epsilon-caprolactone)-poly(ethylene glycol)-poly(D,L-lactide-ran-epsilon-caprolactone) as parenteral drug-delivery systems.
P(DLAX-ran-CLY)n-b-PEG-b-P(DLAX-ran-CLY)ns (P(DLAX-ran-CLY)m: Poly(d,l-lactide-ran-epsilon-caprolactone), PEG: Poly(ethylene glycol), X: d,l-lactyl unit ratio, Y: epsilon-caproyl unit ratio, m : molecular weight of P(DLAX-ran-CLY)), were investigated as the novel parenteral drug-delivery system. The thermal behavior in the DSC characterization and variable viscosity with temperature suggest their potential usuage as a injectable drug-delivery system. The variation of tri-block structure affects the drug release behavior by changing the morphology and also by changing the interaction between the polymer matrix and the hydrophilic drug.
Cho
Hanjin
H
Department of Polymer Science and Engineering, Center for Advanced Functional Polymers, Sungkyunkwan University, Suwon 440-746, South Korea.
Chung
Dongjun
D
Jeongho
An
A
D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D005026:Ethylene Glycols / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry*; D007263:Infusions, Parenteral / Q000379:methods*; D008422:Materials Testing; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D013696:Temperature; D044366:Transition Temperature; D014783:Viscosity
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D005026:Ethylene Glycols; D011091:Polyesters; C476300:poly(epsilon-caprolactone)-b-poly(ethylene glycol); C062968:lactide-caprolactone copolymer; D005472:Fluorouracil