An evaluation of Ki-67 and PCNA expression in conjunctival and eyelid tumours.
The aim of our study was an evaluation of the expression of cell proliferation markers (PCNA and Ki-67) in conjunctival and eyelid papillomas and squamous and basal cell cancers. A series of 9 cases of squamous cell cancer (SCC), 15 cases of basal cell cancer (BCC) and 43 cases of squamous cell papilloma (SCP) were assessed using the immunohistochemical method with monoclonal antibodies. PCNA overexpression was observed in 100% of SCP, in 88.8% of SCC and in 100% of BCC cases. Ki-67 overexpression was seen in 32.5% of cases of SCP, in 22.2% of SCC and in 66.6% of BCC. The results showed that an evaluation of Ki-67 expression is the most valuable cell proliferation marker.
Reszeć
Joanna
J
Department of Pathology, Medical University, Białystok, Poland. joasia@zpk.amb.edu.pl
Kańczuga-Koda
Luiza
L
Sulkowska
Mariola
M
Koda
Mariusz
M
Cylwik
Jacek
J
Barwijuk-Machała
Małgorzata
M
Sulkowski
Stanisław
S
D002280:Basal Cell Carcinoma / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000378:metabolism / Q000473:pathology; D005134:Eye Neoplasms / Q000378:metabolism* / Q000473:pathology; D005142:Eyelid Neoplasms / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D010212:Papilloma / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*
D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen