Lysophospholipid G protein-coupled receptors.
The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger. In this brief review, we note cogent features of lysophospholipid receptors, including the current nomenclature, signaling properties, development of agonists and antagonists, and physiological functions.
Anliker
Brigitte
B
Department of Molecular Biology, Helen L. Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.
Chun
Jerold
J
D000818:Animals; D005298:Fertility / Q000235:genetics; D008246:Lysophospholipids / Q000502:physiology*; D008322:Mammals; D010641:Phenotype; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D008246:Lysophospholipids; D043562:Receptors, G-Protein-Coupled