Epstein-Barr virus-associated smooth muscle tumor of the basal ganglia in an HIV+ child: case report and review of the literature.
We describe the clinicopathologic features of an Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in the basal ganglia of a 10-year-old human immunodeficiency virus (HIV)-positive child. Only a few cases of intracranial smooth muscle tumors are reported in the literature and virtually all of these have been extra-axial, involving the dura or sinuses in HIV+ adults. Our case underscores the need to include an EBV-associated smooth muscle tumor in the differential diagnosis when evaluating intracranial mass lesions in immunodeficient children.
Kumar
Shimareet
S
Department of Anatomic Pathology, Suite 1620, Children's National Medical Center, 111 Michigan Avenue N.W., Washington, DC 20010, USA. skumar@cnmc.org
Santi
Mariarita
M
Vezina
Gilbert
G
Rosser
Tena
T
Chandra
Roma S
RS
Keating
Robert
R
D001479:Basal Ganglia / Q000473:pathology* / Q000821:virology; D001932:Brain Neoplasms / Q000473:pathology* / Q000821:virology; D002648:Child; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D015658:HIV Infections / Q000150:complications*; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host; D008279:Magnetic Resonance Imaging; D008297:Male; D018235:Smooth Muscle Tumor / Q000473:pathology* / Q000821:virology