title: [Repetitive transcranial magnetic stimulation in depression; stimulation of the brain in order to cure the psyche].
abstract: Transcranial magnetic stimulation (TMS) is a non-invasive approach to briefly stimulate or inhibit cortical brain areas. A novel approach entails the delivery of repetitive TMS pulses (rTMS) at a fixed frequency. In rTMS cortical activity is altered beyond the period of actual stimulation. The changes occur locally as well as at a distance in functionally connected brain areas. These features render rTMS a suitable tool to study normal brain functions and the pathophysiology of brain diseases. Furthermore, it is expected that rTMS could be used as a novel therapy for neurological or psychiatric diseases characterised by abnormal cortical activation. This possibility has been studied mostly in patients suffering from depression, where rTMS has been used to restore normal activity in the hypoactive prefrontal cortex. Despite statistically significant therapeutic effects in small sized trials, the clinical implications are still limited.
authors.affiliation: Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen.
authors.forename: R C
authors.initials: RC
authors.lastname: Helmich
authors.forename: A H
authors.initials: AH
authors.lastname: Snijders
authors.forename: R J
authors.initials: RJ
authors.lastname: Verkes
authors.forename: B R
authors.initials: BR
authors.lastname: Bloem
mesh_terms: D003866:Depressive Disorder / Q000628:therapy*; D004599:Electric Stimulation Therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use*; D016896:Treatment Outcome