title: The effects of standard and branched chain amino acid enriched solutions on thermogenesis and energy expenditure in unconscious intensive care patients.
abstract: OBJECTIVE
  This study aims to compare the effects of standard and branched chain amino acid enriched solutions on thermogenesis and energy expenditure in unconscious and mechanically ventilated intensive care patients.
  
  
  METHODS
  The study was carried out at multidisciplinary intensive care unit. Twenty unconscious and mechanically ventilated patients (18-65 years of age) were included in the study. Patients were hemodynamically stable and all received continuous enteral nutrition. Energy expenditure was calculated using the Harris-Benedict Equation for all of the patients. Patients were randomly assigned to receive a 4h infusion of 0.4 g/kg protein as amino acid solution. Group I (n = 10) received standard amino acid solution and group II (n = 10) received branched chain amino acid enriched solution. Energy expenditure, oxygen consumption and carbon dioxide production were measured by indirect calorimetric method every 30 min during the 4h infusion period and 3h thereafter. Rectal temperature was recorded concomitantly with the metabolic measurements throughout the study.
  
  
  RESULTS
  There was a statistically significant increase in body temperature during the infusion of amino acid solution between 30 and 210 min in group I and between 30 and 120 min in group II (P <0.05). We observed a significant increase in energy expenditure at 30, 150, 180 and 210 min in group I and at 30-240 min in group II (P <0.05). There were no differences between the two groups in terms of thermogenesis or energy expenditure values during the study (P >0.05).
  
  
  CONCLUSIONS
  Thermogenesis and energy expenditure values were increased during the parenteral infusion of both standard amino acid and branched chain amino acid enriched solutions in unconscious intensive care patients without any significance in between.
authors.affiliation: Department of Anesthesiology and ICU, Ege University, School of Medicine, Izmir, Turkey. ilkincanka@mcd.cgc.cdu.tr
authors.forename: Ilkin
authors.initials: I
authors.lastname: Cankayali
authors.forename: Kubilay
authors.initials: K
authors.lastname: Demirag
authors.forename: Seden
authors.initials: S
authors.lastname: Kocabas
authors.forename: Ali Resat
authors.initials: AR
authors.lastname: Moral
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000008:administration & dosage*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D001831:Body Temperature; D002153:Calorimetry, Indirect; D002245:Carbon Dioxide / Q000032:analysis; D003422:Critical Care; D004734:Energy Metabolism; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D012121:Respiration, Artificial; D012146:Rest; D012996:Solutions; D022722:Thermogenesis
chemical_list: D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D012996:Solutions; D002245:Carbon Dioxide