title: Trichinella spiralis: activity of the cerebral pyruvate recycling pathway of the host (mouse) in hypoglycemia induced by the infection.
abstract: The activity of the cerebral pyruvate recycling pathway and energy metabolism in mice infected with Trichinella spiralis were investigated using (13)C-NMR and in vivo (31)P-NMR spectroscopy, respectively. The (13)C-NMR analysis, using [1,2-(13)C(2)] acetate as a substrate, of whole-brain extracts demonstrated that activity of the pathway increased when T. spiralis infection induced hypoglycemia in the host. The in vivo (31)P-NMR observation showed that the cerebral ATP in normal level sustained throughout this experiment. These findings indicate that the pyruvate recycling pathway plays a role in the energy supply to the host in hypoglycemia induced by T. spiralis infection.
authors.affiliation: Department of Immunology, Saitama Medical School, 38 Morohongo Moroyama Irumagun, Saitama 350-0495, Japan. masa247@saitama-med.ac.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Nishina
authors.forename: Masahiko
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsushita
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D004734:Energy Metabolism; D006790:Host-Parasite Interactions; D007003:Hypoglycemia / Q000378:metabolism* / Q000469:parasitology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008813:Mice, Inbred ICR; D010759:Phosphorus Isotopes; D019289:Pyruvic Acid / Q000378:metabolism*; D017160:Trichinella spiralis / Q000502:physiology*; D014235:Trichinellosis / Q000150:complications / Q000378:metabolism*
chemical_list: D002247:Carbon Isotopes; D010759:Phosphorus Isotopes; D019289:Pyruvic Acid