title: Antinociceptive effects of hydroalcoholic extract and essential oil of Zataria multiflora.
abstract: Antinociceptive effect of hydroalcoholic extract and essential oil of Zataria multiflora was studied using writhing, tail flick and formalin tests. In tail flick test, the hydroalcholic extract (500 mg/kg, i.p.) and the essential oil (0.3 ml/kg, i.p.) of the plant showed antinociceptive activity (P<0.05). Moreover, they showed antinociceptive activity in writhing and formalin tests.
authors.affiliation: Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran. jaffary@pharm.mui.ac.ir
authors.forename: Fariba
authors.initials: F
authors.lastname: Jaffary
authors.forename: Alireza
authors.initials: A
authors.lastname: Ghannadi
authors.forename: Amir
authors.initials: A
authors.lastname: Siahpoush
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005557:Formaldehyde; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D010938:Plant Oils; D005557:Formaldehyde