Heat shock proteins can protect aged human and rodent cells from different stressful stimuli.
Heat shock proteins (hsps) are induced by stressful stimuli and have been shown to protect cells and organs from such stresses both in vitro and in vivo. Because of this, mildly stressful stimuli, sufficient to induce hsp over-expression can protect against a subsequent more severe stress. In cells from aged individuals, however, no hsp induction is observed upon exposure to stress and no protective effect of a mild stress is observed. Here, we show that bypassing the block to hsp induction by artificially over-expressing hsps, can produce a protective effect against a variety of damaging stimuli in cells from aged rats or aged humans, indicating that hsps can have a protective effect in aged cells, provided successful over-expression can be achieved. Hence, hsps over-expression could be of therapeutic benefit in aged individuals if procedures to over-express the hsps can be developed either by devising non-stressful procedures to induce endogenous hsp over-expression or by developing vectors able to efficiently deliver exogenous hsps.
Alsbury
Sam
S
Medical Molecular Biology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 7HX, UK.
Papageorgiou
Konstantina
K
Latchman
David S
DS
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D016923:Cell Death / Q000502:physiology; D015687:Cell Hypoxia / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D005727:Ganglia, Spinal / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D006360:Heat-Shock Proteins