title: Kigamicins, novel antitumor antibiotics. II. Structure determination.
abstract: Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.
authors.affiliation: Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. kunimotos@bikaken.or.jp
authors.forename: Setsuko
authors.initials: S
authors.lastname: Kunimoto
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Someno
authors.forename: Yohko
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Esumi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naganawa
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000903:Antibiotics, Antineoplastic; D010080:Oxazoles; C484116:kigamicin A; C484115:kigamicin B; C484114:kigamicin C; C484110:kigamicin D; C484112:kigamicin E; D004317:Doxorubicin