Therapeutic potential of decoy oligonucleotides strategy in cardiovascular diseases.
Recent progress in molecular biology has provided several new techniques to inhibit target gene expression. In particular, the application of DNA technology, such as an antisense strategy, to regulate the transcription of disease-related genes in vivo has important therapeutic potential. Recently, transfer of cis-element double-stranded oligonucleotides (ODN) (= decoy) has been reported as a new powerful tool in a new class of antigene strategies for gene therapy. Transfer of the double-stranded ODN corresponding to the cis-sequence will result in attenuation of the authentic cis-trans interaction, leading to removal of trans-factors from the endogenous cis-elements with subsequent modulation of gene expression.
Tomita
Naruya
N
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan. tomita@hp-gm.med.osaka-u.ac.jp
Ogihara
Toshio
T
Morishita
Ryuichi
R
D002318:Cardiovascular Diseases / Q000628:therapy*; D015316:Genetic Therapy; D006801:Humans; D009841:Oligonucleotides / Q000235:genetics*
D009841:Oligonucleotides