title: Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia.
abstract: Over 7 million people worldwide die annually from erratic heart rhythms (cardiac arrhythmias), and many more are disabled. Yet there is no imaging modality to identify patients at risk, provide accurate diagnosis and guide therapy. Standard diagnostic techniques such as the electrocardiogram (ECG) provide only low-resolution projections of cardiac electrical activity on the body surface. Here we demonstrate the successful application in humans of a new imaging modality called electrocardiographic imaging (ECGI), which noninvasively images cardiac electrical activity in the heart. In ECGI, a multielectrode vest records 224 body-surface electrocardiograms; electrical potentials, electrograms and isochrones are then reconstructed on the heart's surface using geometrical information from computed tomography (CT) and a mathematical algorithm. We provide examples of ECGI application during atrial and ventricular activation and ventricular repolarization in (i) normal heart (ii) heart with a conduction disorder (right bundle branch block) (iii) focal activation initiated by right or left ventricular pacing, and (iv) atrial flutter.
authors.affiliation: Cardiac Bioelectricity Research and Training Center, and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA.
authors.forename: Charulatha
authors.initials: C
authors.lastname: Ramanathan
authors.forename: Raja N
authors.initials: RN
authors.lastname: Ghanem
authors.forename: Ping
authors.initials: P
authors.lastname: Jia
authors.forename: Kyungmoo
authors.initials: K
authors.lastname: Ryu
authors.forename: Yoram
authors.initials: Y
authors.lastname: Rudy
mesh_terms: D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D004562:Electrocardiography / Q000379:methods*; D006321:Heart / Q000503:physiopathology*; D006325:Heart Atria / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans