Kinetic resolution of chiral aminoalkenes via asymmetric hydroamination/cyclisation using binaphtholate yttrium complexes.
Chiral binaphtholate yttrium aryl complexes are highly active and enantioselective catalysts for the asymmetric hydroamination of aminoalkenes, as well as the kinetic resolution of alpha-substituted 1-aminopent-4-enes to give trans-2,5-disubstituted pyrrolidines with good enantiomeric excess and high k(rel).
Gribkov
Denis V
DV
Institut für Organische Chemie, Friedrich-Alexander Universität Erlangen-Nürnberg, Henkestr. 42, D-91054 Erlangen, Germany.
Hultzsch
Kai C
KC