title: Novel reaction products from thiobarbituric Acid of biological interest.
abstract: The reactions of 1, 2-dihydro-2-thioxo-4, 6(1H, 5H)pyrimidinedione (1) with some pi-deficients have led to the formation of unexpected heterocyclic products such as anilinomethylenethioxopyrimidinedione, 2, 2'-bis(pyrimidinecarbothioamide), allylthioxopyrimidinecarbothioamide, indenopyranopyrimidine and benzofuropyrimidine derivatives. A possible mechanism for the formation of these products is discussed, and the biological activity is determined.
authors.affiliation: Chemistry Department, Faculty of Science, El-Minia University, El-Minia, A.R. Egypt.
authors.forename: Ashraf A
authors.initials: AA
authors.lastname: Aly
authors.forename: Aboul-Fetouh E
authors.initials: AF
authors.lastname: Mourad
authors.forename: Alaa A
authors.initials: AA
authors.lastname: Hassan
authors.forename: Nasr K
authors.initials: NK
authors.lastname: Mohamed
authors.forename: Bahaa A
authors.initials: BA
authors.lastname: Ali
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: El-Sayed
mesh_terms: D000818:Animals; D002470:Cell Survival; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011743:Pyrimidines / Q000494:pharmacology; D013858:Thiobarbiturates / Q000138:chemical synthesis* / Q000494:pharmacology; D013871:Thiones / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: C486637:6-hydroxy-4-oxo-2-thioxo-1,2,3,4-tetrahydroindeno(2',1'-5,6)pyrano(2,3-d)pyrimidine-5-carbonitrile; D006571:Heterocyclic Compounds; D006993:Hypnotics and Sedatives; D011743:Pyrimidines; D013858:Thiobarbiturates; D013871:Thiones; C029684:thiobarbituric acid