title: Regional glucose metabolism within cortical Brodmann areas in healthy individuals and autistic patients.
abstract: A new Brodmann area (BA) delineation approach was applied to FDG-PET scans of autistic patients and healthy volunteers (n = 17 in each group) to examine relative glucose metabolism (rGMR) during performance of a verbal memory task. In the frontal lobe, patients had lower rGMR in medial/cingulate regions (BA 32, 24, 25) but not in lateral regions (BA 8-10) compared with healthy controls. Patients had higher rGMR in occipital (BA 19) and parietal regions (BA 39) compared with controls, but there were no group differences in temporal lobe regions. Among controls, better recall and use of the semantic-clustering strategy was associated with greater lateral and medial frontal rGMR, while decreased rGMR in medial-frontal regions was associated with greater perseverative/intrusion errors. Patients failed to show these patterns. Autism patients have dysfunction in some but not all of the key brain regions subserving verbal memory performance, and other regions may be recruited for task performance.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, N.Y., USA. erin.hazlett@mssm.edu
authors.forename: Erin A
authors.initials: EA
authors.lastname: Hazlett
authors.forename: Monte S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: Pauline
authors.initials: P
authors.lastname: Hsieh
authors.forename: M Mehmet
authors.initials: MM
authors.lastname: Haznedar
authors.forename: Jimcy
authors.initials: J
authors.lastname: Platholi
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: LiCalzi
authors.forename: Charles
authors.initials: C
authors.lastname: Cartwright
authors.forename: Eric
authors.initials: E
authors.lastname: Hollander
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed / Q000379:methods; D014706:Verbal Learning / Q000502:physiology
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18