Curcumin-induced cell death in two leukemia cell lines: K562 and Jurkat.
Curcumin presents strong antioxidant and anticancer properties. However, molecular mechanisms leading to curcumin-induced cell death are poorly understood. The effect of curcumin was compared in two different leukemia cell lines: K562 and Jurkat. Cell death was induced in both cell lines, and apoptosis pathways were investigated by Western blot analysis. Decreases in pro-caspase 8 and 9 levels were observed. BH(3) interacting domain death agonist (Bid) was also cleaved. Jurkat cells appeared to be more sensitive to curcumin, and apoptosis takes place earlier.
Duvoix
A
A
Laboratoire RCMS, Centre Universitaire du Luxembourg, 162A Avenue de la Faïencerie, L-1511 Luxembourg, Luxembourg.
Morceau
F
F
Schnekenburger
M
M
Delhalle
S
S
Galteau
M M
MM
Dicato
M
M
Diederich
M
M
D000970:Antineoplastic Agents / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects*; D053181:Caspase 8; D053453:Caspase 9; D061945:Caspase Inhibitors; D016923:Cell Death / Q000187:drug effects*; D003474:Curcumin / Q000633:toxicity*; D006801:Humans; D019169:Jurkat Cells; D020014:K562 Cells
D000970:Antineoplastic Agents; D061945:Caspase Inhibitors; C505530:CASP8 protein, human; C506433:CASP9 protein, human; D053181:Caspase 8; D053453:Caspase 9; D003474:Curcumin