Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms.
Minotti
Giorgio
G
Department of Drug Sciences and Centro Studi Invecchiamento, G. d'Annunzio University School of Medicine, Chieti, Italy.
Recalcati
Stefania
S
Menna
Pierantonio
P
Salvatorelli
Emanuela
E
Corna
Gianfranca
G
Cairo
Gaetano
G
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity*; D005293:Ferritins / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006331:Heart Diseases / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D035941:Iron Regulatory Protein 1 / Q000378:metabolism; D035942:Iron Regulatory Protein 2 / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D015394:Molecular Structure; D016254:Mutagenesis, Insertional; D011499:Protein Processing, Post-Translational; D011809:Quinones / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism; D011990:Receptors, Transferrin / Q000378:metabolism; D020218:Response Elements / Q000502:physiology; D013329:Structure-Activity Relationship; D014168:Transferrin / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D005609:Free Radicals; D011809:Quinones; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011990:Receptors, Transferrin; D014168:Transferrin; D004317:Doxorubicin; D005293:Ferritins; D007501:Iron; D035941:Iron Regulatory Protein 1; D035942:Iron Regulatory Protein 2