title: Fragmentation pathway of dopamine transporter ligands: N-substituted-2beta-carbomethoxy-3beta-phenylnortropane derivatives.
abstract: Electron impact mass spectra of iodinated tropane derivatives which are of clinical importance are described. The major fragment ions were found to come from the cleavage of the Calpha-Cbeta bond of the bridgehead nitrogen, affording to hydrogenopyrrolidine derivatives ions. The fragment ions generated from the EI mass spectra were assigned and fragmentation mechanisms were proposed.
authors.affiliation: Laboratoire de Biophysique Médicale, Faculté de Pharmacie, INSERM U316, 31 av. Monge, 37200 Tours, France. mavel@univ-tours.fr
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mavel
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abarbri
authors.forename: Yves
authors.initials: Y
authors.lastname: Frangin
authors.forename: Alain
authors.initials: A
authors.lastname: Duchène
authors.forename: Patrick
authors.initials: P
authors.lastname: Emond
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D004298:Dopamine / Q000737:chemistry*; D050483:Dopamine Plasma Membrane Transport Proteins; D008401:Gas Chromatography-Mass Spectrometry; D008024:Ligands; D008562:Membrane Glycoproteins / Q000737:chemistry*; D026901:Membrane Transport Proteins / Q000737:chemistry*; D015394:Molecular Structure; D009419:Nerve Tissue Proteins / Q000737:chemistry*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D003042:Cocaine; D004298:Dopamine