Metabotropic glutamate 2/3 receptors as drug targets.
Metabotropic glutamate receptors are a family of class III G-protein-coupled receptors comprising eight members (mGluR1-8), which are an attractive target in the central nervous system because of the widespread use of glutamate as the principal excitatory amino acid transmitter. The unique pharmacology of class III G-protein coupled receptors, their forebrain localization in key limbic-related cortical/thalamic/striatal/amygdaloid circuits, and the promise of subtle modulation of glutamatergic neurotransmission make these receptors intriguing targets for a wide variety of neuropsychiatric disorders.
Marek
Gerard J
GJ
Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA. marekgj@lilly.com
D002908:Chronic Disease; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000187:drug effects*; D012640:Seizures / Q000188:drug therapy; D019966:Substance-Related Disorders / Q000188:drug therapy
D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C102718:metabotropic glutamate receptor 3