Cytochrome P450 epoxygenases as EDHF synthase(s).
The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is not constitutive but is determined by a number of physical (fluid shear stress and cyclic stretch) and pharmacological stimuli which also affect responses attributed to an endothelium-derived hyperpolarizing factor (EDHF). This review summarizes the role played by EETs, and the enzymes that generate and metabolize them, in EDHF-mediated responses.
Fleming
Ingrid
I
Klinikum der J.W. Goethe-Universität, Institut für Kardiovaskuläre Physiologie, J.W. Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. fleming@em.uni-frankfurt.de
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D000072467:Cytochrome P450 Family 2; D004730:Endothelium, Vascular / Q000378:metabolism; D004852:Epoxy Compounds / Q000378:metabolism*; D006801:Humans; D010105:Oxygenases / Q000378:metabolism*
D004852:Epoxy Compounds; D016718:Arachidonic Acid; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D000072467:Cytochrome P450 Family 2; C121871:cytochrome P-450 CYP2C8-34 (porcine)