Role of beta2-glycoprotein I, LDL-, and antioxidant levels in hypercholesterolemic elderly subjects.
The levels of electronegative low-density lipoprotein (LDL-), LDL cholesterol oxidability, and plasma levels of molecular antioxidants and of beta(2)-glycoprotein I (beta(2) GPI) were studied in a group of 10 hypercholesterolemic (HC) and 10 normocholesterolemic (NC) elderly subjects. HC subjects showed significantly higher levels of cholesterol, LDL cholesterol, LDL-, and beta(2)GPI than NC, whereas high-density lipoprotein cholesterol and alpha-tocopherol levels were lower in HC as compared with NC subjects. Correlations among LDL- levels, LDL oxidation lag time, beta(2)GPI, and antioxidant plasma levels were studied in 100 HC elderly subjects. Lag time for in vitro LDL oxidation positively correlated with ubiquinol-10 levels (p = 0.008), but not with other antioxidants studied or beta(2)GPI. LDL- and alpha-tocopherol levels showed an inverse and significant correlation (p = 0.018). beta(2)GPI and LDL cholesterol levels were correlated (p = 0.001), whereas no significance was found between LDL- and beta(2)GPI levels (p = 0.057). The physiological significance of alpha-tocopherol and ubiquinol-10 levels on LDL- levels, and the presence of high levels of beta(2)-GPI, are discussed in terms of protective mechanisms operating during the overall atherosclerosis process.
Gomes
Ligia F
LF
Disciplina de Citologia Clínica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, Brazil. lfgomes@plugnet.com.br
Alves
André F
AF
Sevanian
Alex
A
Peres
Clóvis de Araújo
Cde A
Cendoroglo
Maysa S
MS
de Mello-Almada
Clineu
C
Quirino
Lara M
LM
Ramos
Luiz R
LR
Junqueira
Virgínia B C
VB
D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D010084:Oxidation-Reduction; D013223:Statistics as Topic; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood; D053482:beta 2-Glycoprotein I
D000925:Anticoagulants; D000975:Antioxidants; D008078:Cholesterol, LDL; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I; D014451:Ubiquinone; C026663:ubiquinol-10; D024502:alpha-Tocopherol; D001205:Ascorbic Acid