title: [Study on endotoxin levels of acute and chronic periapical periodontitis].
abstract: OBJECTIVE
  To compare the endotoxin levels between acute and chronic periapical periodontitis with different clinical symptoms.
  
  
  METHODS
  10 cases of acute periapical priodontitis(Group 1), 10 cases of chronic periapical periodontitis (group 2, the diameter of apical radiolucency area was less than 2 mm), 10 cases of chronic periapical periodontitis with sinus(group 3, the diameter of apical radiolucency area was greater than 2 mm), 10 cases of chronic periapical periodontitis without sinus (group 4, the diameter of apical radiolucency area was greater than 2 mm), were included in the study. Chromogenic substrate method of limulus amebocyte lysate(LAL) test was used to measure the endotoxin level.
  
  
  RESULTS
  Endotoxin concentrations in group 2 were significantly lower than those in group 1, group 3 and group 4(P < 0.01).
  
  
  CONCLUSIONS
  Endotoxin plays a very important role in the initiation and development of periapical periodotitis and is closely associated with clinical symptoms and apical radiolucency degree.
authors.affiliation: Dept. of Oral Medicine, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Hu
authors.forename: Hong
authors.initials: H
authors.lastname: Tan
authors.forename: Yu-dong
authors.initials: YD
authors.lastname: Xu
mesh_terms: D000208:Acute Disease; D001419:Bacteria; D002908:Chronic Disease; D004731:Endotoxins / Q000032:analysis*; D006801:Humans; D008033:Limulus Test; D010485:Periapical Periodontitis / Q000378:metabolism / Q000382:microbiology*; D012388:Root Canal Irrigants
chemical_list: D004731:Endotoxins; D012388:Root Canal Irrigants