The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.
Radstake
Timothy R D J
TR
University Medical Center Nijmegen, Nijmegen, The Netherlands.
Franke
Barbara
B
Hanssen
Suzanne
S
Netea
Mihai G
MG
Welsing
Paco
P
Barrera
Pilar
P
Joosten
Leo A B
LA
van Riel
Piet L C M
PL
van den Berg
Wim B
WB
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000235:genetics* / Q000503:physiopathology*; D001224:Aspartic Acid / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011859:Radiography; D011956:Receptors, Cell Surface / Q000235:genetics*; D012720:Severity of Illness Index; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D001224:Aspartic Acid; D005998:Glycine