title: Adjuvant low-dose aspirin therapy in poor responders undergoing in vitro fertilization: a prospective, randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  To evaluate the effect of adjuvant low-dose aspirin on utero-ovarian blood flow and ovarian responsiveness in poor responders undergoing IVF.
  
  
  METHODS
  Prospective randomized, double-blind, placebo-controlled study.
  
  
  METHODS
  University-affiliated teaching hospital.
  
  
  METHODS
  Sixty patients classified as poor responders undergoing IVF.
  
  
  METHODS
  Supplementation with low-dose aspirin (80 mg daily) or placebo to a long down-regulation protocol.
  
  
  METHODS
  Doppler measurement of intraovarian and uterine pulsatility index was performed before (baseline) and after ovarian stimulation (day of hCG administration). Duration of use and dose of gonadotropins, cycle cancellation rate, number of mature follicles recruited, and oocytes retrieved were also measured.
  
  
  RESULTS
  High cancellation rates were found in both groups (33.3% vs. 26.7%, placebo vs. treatment). There were no significant differences in total dose of hMG used (66 vs. 57 hMG, 75 IU ampules), median number of mature follicles recruited (3.5 vs. 3.0), or median number of oocytes retrieved (4 vs. 3). No significant differences were found in either intraovarian or uterine artery pulsatility index measured at baseline or on the day of hCG administration.
  
  
  CONCLUSIONS
  Supplementation with low-dose aspirin failed to improve either ovarian and uterine blood flow or ovarian responsiveness in poor responders undergoing IVF.
authors.affiliation: Department of Obstetrics and Gynecology, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. ingridlok@cuhk.edu.hk
authors.forename: Ingrid Hung
authors.initials: IH
authors.lastname: Lok
authors.forename: Shing-Kai
authors.initials: SK
authors.lastname: Yip
authors.forename: Lai Ping
authors.initials: LP
authors.lastname: Cheung
authors.forename: Peter Ho
authors.initials: PH
authors.lastname: Yin Leung
authors.forename: Christopher John
authors.initials: CJ
authors.lastname: Haines
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008596:Menotropins / Q000008:administration & dosage; D006080:Ovarian Follicle / Q000503:physiopathology; D010053:Ovary / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects; D010919:Placebos; D011673:Pulsatile Flow / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D017211:Treatment Failure; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply / Q000000981:diagnostic imaging
chemical_list: D016861:Cyclooxygenase Inhibitors; D010919:Placebos; D008596:Menotropins; D001241:Aspirin