title: Large hiatal hernia in patients with iron deficiency anaemia: a prospective study on prevalence and treatment.
abstract: BACKGROUND
  Although large hiatal hernia may cause bleeding from Cameron erosions, its role in iron deficiency anaemia has been debated, and no data are available on the treatment of these patients with proton pump inhibitors. Aims : To determine the prevalence of large hiatal hernia in out-patients with iron deficiency anaemia and the role of proton pump inhibitors in the prevention of recurrence of anaemia.
  
  
  METHODS
  Two hundred and twenty-eight out-patients underwent upper/lower endoscopy. Those with large hiatal hernia were given an oesophagogram, discontinued iron supplementation and received proton pump inhibitor treatment with (group 1) or without (group 2) surgery. Anaemia was re-assessed during 1 year of follow-up.
  
  
  RESULTS
  Large hiatal hernia was the likely cause of anaemia in 21 patients (9.2%). The median haemoglobin and ferritin values at the diagnosis of anaemia were 7.9 g/dL and 6 micro g/L, respectively. Cameron erosions were found in 33% of patients. Ten and eleven patients were included in groups 1 and 2, respectively. Haemoglobin values were 13.8 g/dL and 13.4 g/dL at 3 months of follow-up, and 13.4 g/dL and 13.8 g/dL at 1 year of follow-up, in groups 1 and 2, respectively.
  
  
  CONCLUSIONS
  Large hiatal hernia may cause iron deficiency anaemia, even without Cameron erosions. Surgery in combination with proton pump inhibitor therapy is no better than proton pump inhibitor therapy alone in preventing the recurrence of anaemia.
authors.affiliation: Department of Digestive and Liver Disease, II School of Medicine, University La Sapienza, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Panzuto
authors.forename: E
authors.initials: E
authors.lastname: Di Giulio
authors.forename: G
authors.initials: G
authors.lastname: Capurso
authors.forename: F
authors.initials: F
authors.lastname: Baccini
authors.forename: G
authors.initials: G
authors.lastname: D'Ambra
authors.forename: G
authors.initials: G
authors.lastname: Delle Fave
authors.forename: B
authors.initials: B
authors.lastname: Annibale
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications* / Q000517:prevention & control; D005260:Female; D005293:Ferritins / Q000097:blood; D006551:Hernia, Hiatal / Q000209:etiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009780:Occult Blood; D011446:Prospective Studies; D054328:Proton Pump Inhibitors; D055502:Secondary Prevention
chemical_list: D054328:Proton Pump Inhibitors; D005293:Ferritins