[Predictive molecular marker of distant metastasis in colorectal cancer].
Tumor development and progression is driven by the accumulation of somatic genetic alterations. Two major pathways have been suggested in colon tumorigenesis. The first one, the APC/B-catenin pathway consists of chromosomal imbalance (Instability) and therefore accumulation of different oncogenes and tumor supressor genes mutations associated with morphological changes. The second one is characterized by "DNA mismatch repair genes" damage with subsequent accumulation of somatic genetic predictive markers of distant metastasis using tissue microarrays in T2N0 colon cancer. In our series, we detected overexpression of survivin, CDK1, MIB1 and topoisomerase IIa in metastatic tumors.
Sanz Esponera
Julián
J
D014408:Biomarkers, Tumor / Q000032:analysis*; D016203:CDC2 Protein Kinase / Q000032:analysis / Q000096:biosynthesis; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D004250:DNA Topoisomerases, Type II / Q000032:analysis / Q000096:biosynthesis; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen / Q000032:analysis / Q000096:biosynthesis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis / Q000096:biosynthesis; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins; D011237:Predictive Value of Tests; D012307:Risk Factors; D000077022:Survivin
C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; D016203:CDC2 Protein Kinase; D004250:DNA Topoisomerases, Type II