title: Sensitivity and specificity of the 76-suprathreshold visual field test to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting: the Thessaloniki eye study.
abstract: OBJECTIVE
  To evaluate the screening performance of the 76-Suprathreshold (76-STHR) visual field test to detect eyes with visual field defect (VFD) as measured by Humphrey threshold testing in a population-based setting.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  All 88 subjects who agreed to participate in the pilot phase of the Thessaloniki Eye Study were included. Participants underwent a 76-STHR visual field test followed by a 30-full threshold (30-2 FTHR) test (Humphrey field analyzer). One eye/subject was randomly selected and included in the analysis. Sensitivity and specificity rates of the 76-STHR to detect eyes with VFD by the 30 to 2 FTHR test were calculated.
  
  
  RESULTS
  When eyes with borderline results in the 30 to 2 FTHR test were classified as having a VFD, sensitivity rates of the 76-STHR to detect eyes with VFD by the 30 to 2 FTHR were 85.2%, 77.8%, and 74.1%, whereas specificity rates were 70%, 78%, and 86%, depending on the cutoff used for the 76-STHR.
  
  
  CONCLUSIONS
  The 76-STHR test showed high sensitivity and low false-negative results at the "at least one point missed" cutoff level criterion to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting. This criterion should be used when screening in a population-based study setting. By contrast, the 76-STHR would not be the appropriate screening test in a primary care setting with limited resources.
authors.affiliation: Department of Ophthalmology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece. ftopouzis@otenet.gr
authors.forename: Fotis
authors.initials: F
authors.lastname: Topouzis
authors.forename: Anne L
authors.initials: AL
authors.lastname: Coleman
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Leonidas
authors.initials: L
authors.lastname: Mavroudis
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Anastasopoulos
authors.forename: Archimidis
authors.initials: A
authors.lastname: Koskosas
authors.forename: Theofanis
authors.initials: T
authors.lastname: Pappas
authors.forename: Stavros
authors.initials: S
authors.lastname: Dimitrakos
authors.forename: M Roy
authors.initials: MR
authors.lastname: Wilson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003430:Cross-Sectional Studies; D005188:False Negative Reactions; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011897:Random Allocation; D012680:Sensitivity and Specificity; D012684:Sensory Thresholds; D014786:Vision Disorders / Q000175:diagnosis*; D015351:Vision Screening / Q000592:standards*; D058609:Visual Field Tests / Q000592:standards*; D014794:Visual Fields