title: Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component.
abstract: The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. The possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed.
authors.affiliation: Departamento de Farmacologia, Universidade Federal de São Paulo, Rua Botucatu, 862, Edificio Leal Prado, CEP 04023-062, São Paulo, SP, Brazil.
authors.forename: Roberto
authors.initials: R
authors.lastname: Frussa-Filho
authors.forename: Michele Themis Moraes
authors.initials: MT
authors.lastname: Gonçalves
authors.forename: Monica Levy
authors.initials: ML
authors.lastname: Andersen
authors.forename: Nilza Pereira
authors.initials: NP
authors.lastname: de Araujo
authors.forename: Cibele Cristina
authors.initials: CC
authors.lastname: Chinen
authors.forename: Sergio
authors.initials: S
authors.lastname: Tufik
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology; D012895:Sleep, REM / Q000187:drug effects* / Q000502:physiology
chemical_list: D000661:Amphetamine