title: Longitudinal changes in plasma glucose values of the 75-g glucose tolerance test in triplet pregnancies.
abstract: We evaluated longitudinal changing patterns of 75 g glucose tolerance test (GTT) in triplet pregnancies. Eight triplet pregnancies were prospectively studied. All triplet pregnancies were fertilized with artificial reproductive techniques; patients showed no glucosuria or fasting hyperglycemia > 100 mg/dL before pregnancy. The 75-g GTT was performed at first, second, and third trimester, as well as at postpartum. Longitudinal changes in glucose levels at fasting, 1 hour, and 2 hours were compared by one-way repeated-measure analysis of variance (ANOVA) and Bonferroni/Dunn test ( p < 0.05). Values were expressed as mean +/- standard deviation. Each of the 3-point values of 75-g GTT decreased after 28 weeks of gestation in triplet pregnancies. During the third trimester, fasting values were significantly decreased compared with postpartum values (65.5 +/- 13.4 versus 74.6 +/- 4.0 mg/dL), and 2-hour values were significantly decreased from those of second-trimester 75-g GTT (116.3 +/- 19.5 versus 99.6 +/- 17.1 mg/dL). Longitudinal glucose values of 75-g GTT improve during third trimester in triplet pregnancies, suggesting that fetoplacental fuel drain may counterbalance maternal insulin resistance.
authors.affiliation: Perinatal Center and Department of Obstetrics and Gynecology, Miyazaki Medical College, Miyazaki, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sameshima
authors.forename: Takafumi
authors.initials: T
authors.lastname: Higo
authors.forename: Tsuyomu
authors.initials: T
authors.lastname: Ikenoue
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008137:Longitudinal Studies; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000097:blood; D011272:Pregnancy, Multiple / Q000097:blood*; D011446:Prospective Studies; D014310:Triplets
chemical_list: D001786:Blood Glucose