Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia.
Distinct expression patterns of pro- and anti-apoptotic proteins may contribute to different prognoses and therapy outcomes in adult versus childhood acute myeloid leukemia (AML). Therefore, we investigated whether expression levels of apoptosis-related proteins CD95, Bcl-2, Bax, Bcl-xL, procaspase-3, XIAP, cIAP-1, and survivin differ between children and adults with de novo AML.
Wuchter
Christian
C
Richter
Stephan
S
Oltersdorf
Doreen
D
Karawajew
Leonid
L
Ludwig
Wolf-Dieter
WD
Tamm
Ingo
I
D000208:Acute Disease; D051017:Apoptosis Regulatory Proteins / Q000097:blood*; D002648:Child; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
D051017:Apoptosis Regulatory Proteins