title: [Effects of Valeriana officinalis var. latifolia on expression of transforming growth factor beta 1 in hypercholesterolemic rats].
abstract: OBJECTIVE
  To evaluate the effect of Valeriana officinalis var latifolia(VOL) on expression of transforming growth factor beta 1 (TGF-beta 1) in hypercholesterolemic rats and study its possible mechanisms.
  
  
  METHODS
  Dietary-induced hypercholesterolemia was induced in male Wistar rats by given 4% cholesterol and 1% cholic acid diet for 16 weeks. Changes of serum lipid, urinary albumin, renal function and Mesangial matrix index were assessed. Moreover, immunohistochemical stain for TGF-beta 1 and type IV collagen were performed.
  
  
  RESULTS
  VOL could reduce the serum levels of total cholesterol, low density lipoprotein, urinary albumin and serum creatinine. Light microscopy and immunohistochemical stain revealed that in the same time of lowing serum lipid, Mesangial matrix index was significantly reduced, accompanied by decreased expression of TGF-beta 1 and type IV collagen.
  
  
  CONCLUSIONS
  VOL has the protective effect on lipid-induced nephropathy, and the inhibition of TGF-beta 1 expression might be the mechanism of VOL on renal protection.
authors.affiliation: Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China.
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Si
authors.forename: Ru-han
authors.initials: RH
authors.lastname: Jia
authors.forename: Cong-xin
authors.initials: CX
authors.lastname: Huang
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Ding
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Liu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000378:metabolism* / Q000473:pathology; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1; D014632:Valerian / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1