Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis.
Recent cross-sectional, population-based echocardiographic studies show that about half of all patients with heart failure have preserved left ventricular systolic function (HF-PSF). Cohort studies of hospitalized patients show a smaller proportion of HF-PSF. Compared to those with reduced systolic function, patients with HF-PSF are more often female, older, less likely to have coronary artery disease, and more likely to have hypertension. Patients with HF-PSF are less symptomatic and receive different pharmacologic therapy than patients with reduced systolic function. Morbidity and mortality rates in patients with HF-PSF are high but not quite as high as in patients with reduced systolic function. Though much has recently been learned about the syndrome of HF-PSF, many questions remain to be answered, not least how it should be treated.
Hogg
Karen
K
Department of Cardiology, Western Infirmary, Glasgow G12 8QQ, Scotland, United Kingdom.
Swedberg
Karl
K
McMurray
John
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002317:Cardiovascular Agents / Q000627:therapeutic use; D015897:Comorbidity; D005260:Female; D006333:Heart Failure / Q000188:drug therapy / Q000191:economics / Q000453:epidemiology* / Q000503:physiopathology*; D006760:Hospitalization / Q000191:economics; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology*; D011379:Prognosis; D011788:Quality of Life; D016277:Ventricular Function, Left / Q000502:physiology*
D002317:Cardiovascular Agents