title: [The influence on hemodynamics of myocardial ischemic dogs and blood pressure of animals with shenfu injection].
abstract: OBJECTIVE
  To investigate the influence of Shenfu injection on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of dogs and rats.
  
  
  METHODS
  Myocardial ischemic model was made and hypotension in the dogs was induced with ligating left front descending limb coronary artery method, and secondary hypertension by narrowing nephridium artery of rats, Shenfu injection was administered with 5, 10 mL.kg-1 to the above dogs and rats separately to investigate the influence of it on the hemodynamic indexes of myocardial ischemic dogs and blood pressure of rats.
  
  
  CONCLUSIONS
  Shenfu injection enhanced the capacity of myocardial work markedly; it augmented the myocardium contractility and cardiac output without raising the oxygen consume, and at the same time it returned normal the blood pressure in myocardial ischemic; but it had no effects on the normal blood pressure and secondary hypertension of rats.
authors.affiliation: School of Basic Medical Science and Medical Jurisprudence of Sichuan University, Chengdu 610041, Sichuan, China. yang Fangju hotmail
authors.forename: Fang-ju
authors.initials: FJ
authors.lastname: Yang
authors.forename: Zheng-rong
authors.initials: ZR
authors.lastname: Wang
authors.forename: Dai-ping
authors.initials: DP
authors.lastname: Lin
authors.forename: Yi
authors.initials: Y
authors.lastname: Qu
authors.forename: Hua-hu
authors.initials: HH
authors.lastname: Yin
authors.forename: Li-li
authors.initials: LL
authors.lastname: Shi
authors.forename: Hui-ling
authors.initials: HL
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.forename: Yue-qi
authors.initials: YQ
authors.lastname: Wang
authors.forename: Rong-tao
authors.initials: RT
authors.lastname: Liu
mesh_terms: D031841:Aconitum / Q000737:chemistry; D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology; D007267:Injections; D008297:Male; D017202:Myocardial Ischemia / Q000503:physiopathology*; D005894:Panax / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D044005:Tetrahydroisoquinolines / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D044005:Tetrahydroisoquinolines; C012348:higenamine