The broad ligament: a review of its anatomy and development in different species and hormonal environments.
The broad ligament is a double fold of peritoneum forming a mesentery for the human female genital tract. We investigated the anatomy of the broad ligament in different species and its hormonal regulation to determine if it had a role in gonadal positioning. The medical and veterinary literature was reviewed for descriptions of broad ligament anatomy and development. In addition, four adult female rats were dissected to compare the macroscopic anatomy of the broad ligament with any homologous structures in the male (n = 2). Detailed review was made of human males with persistent Müllerian duct syndrome (PMDS) and of bovine freemartin calves to determine the effect of abnormal hormonal environments on broad ligament development. Human and veterinary texts show variable broad ligament development between species, most being consistent with the size and shape of the uterus and uterine tubes. The broad ligament in adult female rats is a simple peritoneal fold and is homologous with the mesentery of the testis and vas deferens in males. Patients with PMDS and bovine freemartins have a broad ligament with intermediate anatomy. In PMDS the broad ligament is elongated and narrow, and not attached to the pelvic wall. The broad ligament is the mesentery of the genital ducts, and its anatomy varies with the degree of Müllerian duct fusion. The absence of a human male homologue is unusual, as the genital mesentery persists in male rodents. Apparent lack of a male homologue in the human may relate to obliteration of the processus vaginalis. The variable development of the broad ligament in pathological conditions is consistent with a role for steroid hormones in its development.
Miller
Anne
A
F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia.
Hong
Matthew K-H
MK
Hutson
John M
JM
D000328:Adult; D000818:Animals; D054304:Anti-Mullerian Hormone; D001956:Broad Ligament / Q000033:anatomy & histology* / Q000196:embryology*; D002335:Carnivora / Q000033:anatomy & histology / Q000196:embryology; D002417:Cattle; D018397:Equidae / Q000033:anatomy & histology / Q000196:embryology; D005260:Female; D005611:Freemartinism; D006023:Glycoproteins / Q000502:physiology; D042341:Gonadal Hormones / Q000502:physiology*; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000002:abnormalities / Q000033:anatomy & histology; D010537:Peritoneum / Q000033:anatomy & histology*; D051381:Rats / Q000033:anatomy & histology / Q000196:embryology; D012418:Ruminants / Q000033:anatomy & histology / Q000196:embryology; D013552:Swine / Q000033:anatomy & histology / Q000196:embryology; D013735:Testicular Hormones / Q000502:physiology
D006023:Glycoproteins; D042341:Gonadal Hormones; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone