Autocatalytic domino Michael reaction leading to bicyclo[2.2.2]octane-2,5-dione derivatives.
In the presence of a catalytic amount of lithium amide, the reaction of oxophorone with electron-deficient olefins afforded bicyclo[2.2.2]octane-2,5-dione derivatives in high yields. The reaction proceeds autocatalytically by an enolate of bicyclo[2.2.2]octane-2,5-dione, generated by an initial domino Michael reaction.
Hagiwara
Hisahiro
H
Graduate School of Science and Technology, Niigata University, 8050, 2-Nocho, Ikarashi, Niigata 950-2181, Japan. hagiwara@gs.niigata-u.ac.jp
Endou
Satoru
S
Fukushima
Masakazu
M
Hoshi
Takashi
T
Suzuki
Toshio
T