[Effect of kebimin decoction in treating allergic rhinitis and on blood levels of nitric oxide and superoxide dismutase].
OBJECTIVE
To observe the therapeutic effect of Kebimin decoction (KD) on allergic rhinitis (AR) and its effect on blood levels of nitric oxide (NO) and superoxide dismutase (SOD) activity.


METHODS
Eighty-two AR patients were randomly divided into two groups, the treated group and the control group, 41 in each group. To the treated group, KD was given one dose per day for 10 days as one therapeutic course and 1-3 courses were given successively. The control group was treated with Xinfang Rhinitis capsule for 30 days. Blood levels were determined and compared before and after treatment.


RESULTS
The total effective rate in the treated group was 93%, which was better than that in the control group (51%), the difference was significant (chi 2 = 17.704, P < 0.01). Serum level of NO was higher and that of SOD activity was lower in the AR patients than that in healthy persons (P < 0.01), KD could significantly lower the former and increase the latter (P < 0.01).


CONCLUSIONS
The therapeutic effect of KD in treating AR was significant, its mechanism might be related with the lowering of NO and increasing of SOD activity in serum, as well as the scavenging of oxygen free radical.
Zhang
Shi-fu
SF
Department of Otorhinolaryngology, Affiliated Hospital of Guangdong Medical College, Guangdong 524001. zhshifu@gdmc.edu
Cheng
Li-lan
LL
Huang
Di-nan
DN
D000293:Adolescent; D000328:Adult; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D008517:Phytotherapy; D012221:Rhinitis, Allergic, Perennial / Q000097:blood / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood*
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D009569:Nitric Oxide; D013482:Superoxide Dismutase