title: Pentoxyfylline in and prevention and treatment of chronic lung disease.
abstract: The anti-inflammatory effects of pentoxfylline are associated with a number of clinical benefits. These include reduction in mortality in patients who have undergone bone marrow transplants or suffer peritonitis. In infants with sepsis, a reduction in mortality has also been associated with pentoxyfylline administration. The anti-inflammatory effects of pentoxyfylline, as well as its bronchodilator, diuretic and respiratory muscle stimulant effects suggest it may have a useful role in BPD. Interim analysis of a prophylactic trial suggests pentoxyfylline may reduce treatment requirements after the neonatal period and that, in established BPD, pentoxyfylline and dexamethasone may be of similar efficacy.
authors.affiliation: Department of Neonatology, Medical College Jagiellonian University, Cracow, Poland. lauterbach@pro.onet.pl
authors.forename: R
authors.initials: R
authors.lastname: Lauterbach
authors.forename: D
authors.initials: D
authors.lastname: Pawlik
authors.forename: M
authors.initials: M
authors.lastname: Zembala
authors.forename: J
authors.initials: J
authors.lastname: Szymura-Oleksiak
authors.forename: I
authors.initials: I
authors.lastname: Lisowska-Miszczyk
authors.forename: D
authors.initials: D
authors.lastname: Kowalczyk
authors.forename: J
authors.initials: J
authors.lastname: Bury
mesh_terms: D002908:Chronic Disease; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000188:drug therapy* / Q000517:prevention & control*; D010431:Pentoxifylline / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D004791:Enzyme Inhibitors; D010431:Pentoxifylline