Thallium induces apoptosis in Jurkat cells.
Thallium induces swelling in mitochondria and apoptosis in Jurkat cells. Both the swelling and the apoptosis are inhibited by means of cyclosporine A (CsA), thus suggesting that these phenomena result from the opening of the membrane transition pore (MTP) in mitochondria. Therefore, apoptosis can be explained as due to the opening of the MTP in mitochondria.
Bragadin
Marcantonio
M
Dipartimento di Scienze Ambientali, Università di Venezia, DD2137 30123 Venezia, Italy. bragadin@unive.it
Toninello
Antonio
A
Bindoli
Alberto
A
Rigobello
Maria Pia
MP
Canton
Marcella
M
D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D016572:Cyclosporine / Q000494:pharmacology; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects / Q000502:physiology; D019169:Jurkat Cells; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D008933:Mitochondrial Swelling / Q000187:drug effects; D009336:Necrosis; D010710:Phosphates / Q000494:pharmacology; D013793:Thallium / Q000494:pharmacology*
D010710:Phosphates; D016572:Cyclosporine; D013793:Thallium