title: Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants.
abstract: Isogenic strains containing insertional disruptions of 10 Haemophilus influenzae Rd genes were investigated for their effects on the susceptibility of the organism to various classes of antimicrobial compounds. MIC results show that HI1462, which encodes an Escherichia coli TolC homolog, is the third component of the H. influenzae AcrAB pump.
authors.affiliation: Antibacterials, Pfizer, Groton, Connecticut 06340, USA. catherine.m.trepod@pfizer.com
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Trepod
authors.forename: John E
authors.initials: JE
authors.lastname: Mott
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics; D006193:Haemophilus influenzae / Q000235:genetics*; D008074:Lipoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D016254:Mutagenesis, Insertional; D009154:Mutation / Q000235:genetics* / Q000502:physiology*; D009841:Oligonucleotides / Q000235:genetics
chemical_list: D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009841:Oligonucleotides; C083497:AcrA protein, E coli; C083496:AcrB protein, E coli; C073126:tolC protein, E coli