title: First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.
abstract: Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.
authors.affiliation: Institute of Medical Microbiology and Hygiene, University of Lübeck, 23538 Luebeck, Germany. Jens.Gieffer@hygiene.ukl.mu-luebeck.de
authors.forename: Jens
authors.initials: J
authors.lastname: Gieffers
authors.forename: Jan
authors.initials: J
authors.lastname: Rupp
authors.forename: Andreas
authors.initials: A
authors.lastname: Gebert
authors.forename: Werner
authors.initials: W
authors.lastname: Solbach
authors.forename: Matthias
authors.initials: M
authors.lastname: Klinger
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells; D006801:Humans; D008854:Microscopy, Electron
chemical_list: D000900:Anti-Bacterial Agents