Evolution of angiographic restenosis rate and late lumen loss after intracoronary beta radiation for in-stent restenotic lesions.
The aim of this study was to investigate the time course of angiographic restenosis rate and late loss after successful percutaneous coronary intervention and vascular brachytherapy with beta-irradiation using strontium-90/yttrium-90 in 98 patients who were prospectively enrolled into a quantitative angiographic and clinical follow-up protocol at 6, 12, and 24 months after the index procedure, regardless of their symptom status. Actuarial restenosis rates measured 11.2 +/- 5% at 6 months of follow-up, 24.5 +/- 5% at 12 months, and 28.5 +/- 6% at 24 months, respectively. Late loss of the stent segment during the first 6 months measured 0.38 +/- 0.40 mm (6 to 12 months: 0.25 +/- 0.38 mm; 12 to 24 months: 0.16 +/- 0.32 mm), of the injured segment 0.27 +/- 0.21 mm (6 to 12 months: 0.21 +/- 0.26 mm; 12 to 24 months: 0.13 +/- 0.24 mm), of the irradiated segment 0.18 +/- 0.29 mm (6 to 12 months: 0.19 +/- 0.31 mm; 12 to 24 months: 0.11 +/- 0.27 mm), and of the analysis segment 0.18 +/- 0.36 mm (6 to 12 months: 0.17 +/- 0.29 mm; 12 to 24 months: 0.11 +/- 0.20 mm). Restenosis after angioplasty and beta-irradiation of in-stent restenotic lesions is not complete within 6 months but is sustained with a gradual decrease over 24 months.
Schiele
Thomas M
TM
Cardiology Division, Department of Medicine, Medizinische Klinik und Poliklinik-Innenstadt, University Hospital, Munich, Germany. Thomas.Schiele@medinn.med.uni-muenchen.de
Pöllinger
Barbara
B
Kantlehner
Ralf
R
Rieber
Johannes
J
König
Andreas
A
Seelig
Viktória
V
Krötz
Florian
F
Sohn
Hae-Young
HY
Siebert
Uwe
U
Dühmke
Eckhart
E
Theisen
Karl
K
Klauss
Volker
V
D000206:Actuarial Analysis; D000368:Aged; D001918:Brachytherapy; D017023:Coronary Angiography; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000528:radiation effects*; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D013326:Strontium Radioisotopes / Q000627:therapeutic use; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes