Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium.
Rapid advances in generating new mouse genetic models for lung neoplasia provide a continuous challenge for pathologists and investigators. Frequently, phenotypes of new models either have no precedents or are arbitrarily attributed according to incongruent human and mouse classifications. Thus, comparative characterization and validation of novel models can be difficult. To address these issues, a series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer held in Boston on June 20-22, 2001. The panel performed a comparative evaluation of 78 cases of mouse and human lung proliferative lesions, and recommended development of a new practical classification scheme that would (a) allow easier comparison between human and mouse lung neoplasms, (b) accommodate newly emerging mouse neoplasms, and (c) address the interpretation of benign and preinvasive lesions of the mouse lung. Subsequent discussions with additional experts in pulmonary pathology resulted in the current proposal of a new classification. It is anticipated that this classification, as well as the complementary digital atlas of virtual histological slides, will help investigators and pathologists in their characterization of new mouse models, as well as stimulate further research aimed at a better understanding of proliferative lesions of the lung.
Nikitin
Alexander Yu
AY
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853-6401, USA. an58@cornell.edu
Alcaraz
Ana
A
Anver
Miriam R
MR
Bronson
Roderick T
RT
Cardiff
Robert D
RD
Dixon
Darlene
D
Fraire
Armando E
AE
Gabrielson
Edward W
EW
Gunning
William T
WT
Haines
Diana C
DC
Kaufman
Matthew H
MH
Linnoila
R Ilona
RI
Maronpot
Robert R
RR
Rabson
Alan S
AS
Reddick
Robert L
RL
Rehm
Sabine
S
Rozengurt
Nora
N
Schuller
Hildegard M
HM
Shmidt
Elena N
EN
Travis
William D
WD
Ward
Jerrold M
JM
Jacks
Tyler
T
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification* / Q000473:pathology; D051379:Mice