[Growth-suppression effect of hydroxyurea on meningioma cells in vitro].
To investigate the tumor-suppression effect of hydroxyurea on meningioma cells and its possible mechanism.



The meningioma cells were cultured in medium containing varied doses of hydroxyurea (5x10(-3)mol/L, 5x10(-4)mol/L, 5x10(-5)mol/L), the cell growth was measured by MTT method, cell apoptosis was observed with flow cytometry (FCM).



MTT measurement demonstrated that the administration of hydroxyurea led to a dose-dependent suppression in cell proliferation and FCM showed a dose-dependent increase in apoptosis rate.



Hydroxyurea can inhibit meningioma cell growth in vitro, which is most likely associated with apoptosis of the tumor cells.
Yang
Shu-xu
SX
Department of Neurosurgery, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China. yangshuxu5@hotmail.com
Wang
Yi-rong
YR
Gan
Hai-peng
HP
D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology*; D008297:Male; D008579:Meningioma / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged
D006918:Hydroxyurea