title: Dichotomy between CD1a+ and CD83+ dendritic cells in lymph nodes during SIV infection of macaques.
abstract: The prevalence and differentiation of dendritic cells (DC) in lymphoid tissue of simian immunodeficiency virus (SIV)-infected cynomolgus monkeys was studied during disease progression. Lymph node biopsies were consecutively obtained from clinical rapid and slow progressors until the development of disease consistent with simian acquired immunodeficiency syndrome (sAIDS) occurred. Quantitative evaluation of CD1a+ DC and the expression of DC antigens related to maturation (CD83, DC-LAMP and S100b) were performed at the single cell level by in situ image analysis. Despite a persistent prevalence of CD1a+ DC in lymphoid tissue during disease progression, there was a subsequent drop of mature CD83+, DC-LAMP+ and S100b+ DC, correlating with the decline of CD4+ T cells in blood. Thus, disease progression to sAIDS was associated with impaired maturation of DC, and lack of CD83, DC-LAMP and S100b expression.
authors.affiliation: Cancer Center Karolinska, Karolinska Hospital, Stockholm, Sweden. johan.soderlund@impi.ki.se
authors.forename: Johan
authors.initials: J
authors.lastname: Söderlund
authors.forename: Charlotta
authors.initials: C
authors.lastname: Nilsson
authors.forename: Karin
authors.initials: K
authors.lastname: Loré
authors.forename: Esmeralda
authors.initials: E
authors.lastname: Castanos-Velez
authors.forename: Marianne
authors.initials: M
authors.lastname: Ekman
authors.forename: Thomas
authors.initials: T
authors.lastname: Heiden
authors.forename: Gunnel
authors.initials: G
authors.lastname: Biberfeld
authors.forename: Jan
authors.initials: J
authors.lastname: Andersson
authors.forename: Peter
authors.initials: P
authors.lastname: Biberfeld
mesh_terms: D000818:Animals; D015703:Antigens, CD; D018949:Antigens, CD1 / Q000276:immunology; D015816:Cell Adhesion Molecules, Neuronal / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology*; D004195:Disease Models, Animal; D058851:GPI-Linked Proteins; D007136:Immunoglobulins / Q000276:immunology; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000821:virology; D008253:Macaca mulatta / Q000276:immunology* / Q000821:virology; D008562:Membrane Glycoproteins / Q000276:immunology; D009414:Nerve Growth Factors / Q000276:immunology; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology*; D000097802:CD83 Antigen
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D015816:Cell Adhesion Molecules, Neuronal; D058851:GPI-Linked Proteins; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D000097802:CD83 Antigen; C419393:CD1a antigen; C095362:limbic system-associated membrane protein