title: High pressure: a promising tool for multicomponent reactions.
abstract: In this paper the application of high pressure in multicomponent reactions is discussed. Using high pressure the scope of certain multicomponent reactions can be increased. Reactions are described that can only be performed in a multicomponent fashion when high pressure catalysis is applied. An overview of high pressure catalysed multicomponent reactions is presented with special attention to the domino [4 + 2]/[3 + 2] cycloaddition reaction.
authors.affiliation: Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands.
authors.forename: Leon W A
authors.initials: LW
authors.lastname: van Berkom
authors.forename: George J T
authors.initials: GJ
authors.lastname: Kuster
authors.forename: Hans W
authors.initials: HW
authors.lastname: Scheeren
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D015195:Drug Design; D015394:Molecular Structure; D011312:Pressure; D013329:Structure-Activity Relationship