Rodent models for HIV-1 infection and disease.
The development of a predictive, small animal model for human immunodeficiency virus type 1 (HIV-1) disease would greatly facilitate the analysis of many aspects of viral infection, pathogenesis and treatment. While numerous small animal models exist which emulate various aspects of HIV-1 infection and/or disease in humans, none of these models support robust HIV-1 replication within the context of an intact immune system. Despite this major limitation, these models have helped to elucidate different aspects of HIV-1 pathogenesis in humans. Moreover, recent advances regarding the underlying nature of the blocks to viral replication in non-human cells have raised the possibility that rodents may be engineered to support HIV-1 infection. This review will focus on recent attempts to develop a rodent model for HIV-1 disease, and will also describe currently available systems for studying HIV-1.
van Maanen
Marc
M
Department of Molecular Virology and Microbiology, Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Sutton
Richard E
RE
D000818:Animals; D030801:Animals, Genetically Modified; D004195:Disease Models, Animal; D015658:HIV Infections; D015497:HIV-1 / Q000254:growth & development*; D006801:Humans; D051379:Mice; D051381:Rats; D014779:Virus Replication