6,7-dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or -sensitive Staphylococcus aureus to beta-lactams.
We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to beta-lactam antibiotics from 8- to 32,800-fold.
Sato
Youichi
Y
Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan.
Shibata
Hirofumi
H
Arakaki
Naokatu
N
Higuti
Tomihiko
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004357:Drug Synergism; D047309:Flavones; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013997:Time Factors; D047090:beta-Lactams / Q000494:pharmacology*
C485383:6,7-dihydroxyflavone; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D047309:Flavones; D005419:Flavonoids; D047090:beta-Lactams