Signal transduction: implications for Ras-dependent ERK signaling.
Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR.
Ory
Stéphane
S
Laboratory of Protein Dynamics and Signaling, NCI-Frederick, Frederick, Maryland 21702, USA.
Morrison
Deborah K
DK
D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D029867:Xenopus Proteins / Q000378:metabolism*; D018631:ras Proteins / Q000378:metabolism*
D029867:Xenopus Proteins; C480974:IMP protein, Xenopus; D044767:Ubiquitin-Protein Ligases; D011494:Protein Kinases; C097199:KSR-1 protein kinase; D020928:Mitogen-Activated Protein Kinases; D018631:ras Proteins