title: Thoracic high-resolution computed tomography in the diagnosis of metastatic carcinoma.
abstract: Three dogs were presented for investigation of recurrent pyrexia of unknown origin, chronic vomiting and respiratory distress, respectively. One dog was markedly underweight and the other two were cachexic. Physical examination and initial diagnostic tests failed to establish the underlying cause of the presenting signs. Thoracic radiographs were within normal limits for the age of the dog. In each case there was a high index of suspicion for an occult neoplastic process in view of the profound unexplained weight loss present. High-resolution computed tomography (HRCT) of the thorax was performed. The lung fields were divided into three zones for analysis and a novel classification scheme was used to describe the HRCT findings in each zone. Postmortem examination and histopathology confirmed the presence of an infiltrating metastatic carcinoma in all three cases. The HRCT changes correlated closely with the pathological findings. The authors conclude that HRCT of the lung should be considered for pulmonary metastatic screening in the dog and introduce a classification system for HRCT findings, based on terminology used in human medicine.
authors.affiliation: Department of Veterinary Clinical Studies, Faculty of Veterinary Studies, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Bearsden, Glasgow G61 1QH.
authors.forename: V S
authors.initials: VS
authors.lastname: Johnson
authors.forename: I K
authors.initials: IK
authors.lastname: Ramsey
authors.forename: H
authors.initials: H
authors.lastname: Thompson
authors.forename: T A
authors.initials: TA
authors.lastname: Cave
authors.forename: F J
authors.initials: FJ
authors.lastname: Barr
authors.forename: H
authors.initials: H
authors.lastname: Rudorf
authors.forename: A
authors.initials: A
authors.lastname: Williams
authors.forename: M
authors.initials: M
authors.lastname: Sullivan
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary; D000818:Animals; D002277:Carcinoma / Q000150:complications / Q000000981:diagnostic imaging / Q000556:secondary / Q000662:veterinary; D016022:Case-Control Studies; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D004285:Dogs; D005260:Female; D005334:Fever / Q000209:etiology / Q000662:veterinary; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000556:secondary / Q000662:veterinary*; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000150:complications / Q000000981:diagnostic imaging / Q000662:veterinary; D012131:Respiratory Insufficiency / Q000209:etiology / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary*