Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease.
Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C-->T and 1298 A-->C) and transcobalamin genes (TCN1 776 C-->G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677T (odds ratio 6.28, 95% CI 2.88-16.20, p < 0.0001) and APOE epsilon4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677T and APOE epsilon4 alleles.
Anello
Guido
G
IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina (EN), Italy.
Guéant-Rodríguez
Rosa-Maria
RM
Bosco
Paolo
P
Guéant
Jean-Louis
JL
Romano
Antonino
A
Namour
Bernard
B
Spada
Rosario
R
Caraci
Filippo
F
Pourié
Gregory
G
Daval
Jean-Luc
JL
Ferri
Raffaele
R
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011624:Pteroylpolyglutamic Acids / Q000627:therapeutic use; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D014155:Transcobalamins / Q000235:genetics / Q000378:metabolism; D014805:Vitamin B 12 / Q000627:therapeutic use
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D011624:Pteroylpolyglutamic Acids; D014155:Transcobalamins; D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D014805:Vitamin B 12