Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.
The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2'-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives.
Jiang
Xiang-Jun
XJ
Department of Chemistry, University at Buffalo, Amherst, New York 14260, USA.
Kalman
Thomas I
TI
D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
C407206:4-formyl-4-imidazolin-2-one; D007093:Imidazoles; D003857:Deoxyuridine; D014529:Uridine