Synthesis of poly(glycolide) in supercritical carbon dioxide in the presence of a hydrocarbon stabiliser.
The first example of a hydrocarbon based stabiliser for ring opening polymerisation in scCO(2) is reported, allowing the preparation of solvent free poly(glycolide) microparticles in a clean, one step process.
Bratton
Daniel
D
School of Chemistry, University of Nottingham, Nottingham, UK.
Brown
Malcolm
M
Howdle
Steven M
SM
D002245:Carbon Dioxide / Q000737:chemistry*; D006838:Hydrocarbons / Q000737:chemistry* / Q000494:pharmacology; D008863:Microspheres; D036103:Nanotechnology; D010316:Particle Size; D011100:Polyglycolic Acid / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis; D012997:Solvents / Q000737:chemistry
D006838:Hydrocarbons; D011108:Polymers; D012997:Solvents; D002245:Carbon Dioxide; D011100:Polyglycolic Acid