title: Miltefosine: an oral drug for visceral leishmaniasis.
abstract: Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmania in vitro and animal model. Based on these experiences this drug was tried against human visceral leishmaniasis and found to be highly effective and achieved 97% and 94% cure in phase 2 and phase 3 trial in children.
authors.affiliation: Institute of Medical Science, Banaras Hindu University, Varanasi, India. sriharsh2@rediffmail.com
authors.forename: Rajniti
authors.initials: R
authors.lastname: Prasad
authors.forename: Ranjeet
authors.initials: R
authors.lastname: Kumar
authors.forename: B P
authors.initials: BP
authors.lastname: Jaiswal
authors.forename: Utpal Kant
authors.initials: UK
authors.lastname: Singh
mesh_terms: D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine