title: [Clinical significance of transrectal ultrasound in detecting of rectal cancer margin and deciding of distal surgical incisal edge].
abstract: OBJECTIVE
  To study the role of transrectal ultrasound in detecting and deciding rectal cancer margin and surgical incisal edge.
  
  
  METHODS
  33 surgical specimens of rectal carcinoma were examined with transrectal ultrasound. Cancerous margin and surgical incisal edge were determined. The results were compared with pathological examination. p53 and K-ras gene mutation as tumor molecular markers of residue cancer cells were detected in incisal edge tissue with PCR-SSCP method.
  
  
  RESULTS
  General accuracy for cancer infiltration depth with transrectal ultrasound was 86.6%. For mucosa and submucosa infiltration lesions, the accuracy was 72.7%. For lamina muscularis, the accuracy was 90.9%. And for adventitia and peripheral tissue infiltration of rectum, the accuracy was 88.5% and 100% respectively. No remains of cancer cells and tumor molecular markers were detected at distal incisal edges of 1.0 cm, 2.0 cm and 3.0 cm determined with transrectal ultrasound.
  
  
  CONCLUSIONS
  Rectal cancer margine and surgical incisal edge determined with transrectal ultrasound are close to examined by pathology. Transrectal ultrasound is helpful and reliable to define incisal edge in rectal cancer surgery.
authors.affiliation: Department of General Surgery, Beijing Military Area General Hospital, Beijing 100700, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yu
authors.forename: Shi-yong
authors.initials: SY
authors.lastname: Li
authors.forename: Zhen-jia
authors.initials: ZJ
authors.lastname: Liang
authors.forename: Shu-jun
authors.initials: SJ
authors.lastname: Yuan
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Yu-wang
authors.initials: YW
authors.lastname: Tian
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000601:surgery; D004252:DNA Mutational Analysis; D019160:Endosonography; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D009154:Mutation; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012004:Rectal Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D012007:Rectum / Q000000981:diagnostic imaging*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53