title: Herpes simplex and aphthous ulcerations: presentation, diagnosis and management--an update.
abstract: The most common pathologic alterations seen by dentists are oral mucosal ulcerations, particularly those related to the herpes simplex virus and those produced by the autoimmune phenomenon known as recurrent aphthous stomatitis. Because the general frequency and clinical similarity of these conditions often make it difficult to distinguish one from the other, therapeutic intervention may be inappropriate. An improved understanding of the virologic and local immunologic alterations within the oral mucosa has led to a better understanding of these conditions and to the development of improved treatment strategies within the general practice setting for a significant number of otherwise healthy patients.
authors.affiliation: Johns Hopkins School of Medicine, Dental and Oral Medicine Division, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
authors.forename: James J
authors.initials: JJ
authors.lastname: Sciubba
mesh_terms: D000779:Anesthetics, Local / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006560:Herpes Labialis / Q000175:diagnosis* / Q000628:therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009061:Mouth Mucosa / Q000473:pathology; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D013283:Stomatitis, Herpetic / Q000175:diagnosis* / Q000628:therapy / Q000821:virology
chemical_list: D000779:Anesthetics, Local; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D002482:Cellulose; C008079:hydroxypropylcellulose