title: [Analysis of polymorphism of the HLA-DRB1 gene in populations from the Volga-Ural region].
abstract: Polymorphism at the HLA-DRB1 locus in six Turkic (Bashkirs, Tatars, and Chuvashes) and Finno-Ugric (Udmurts, Maris, and Komis) populations of the Volga--Ural region was studied by PCR. A total of 12 DRB1 specificities displaying population-specific frequency distribution patterns were described. The most frequently observed specificities in Bashkirs and Udmurts were DRB1*07 (25 and 34%, respectively) and *15 (by 15%). In Tatars the prevalence of *04 (18%), *01 (17%), *07 (16%) and *15 (13%) specificities was observed, while in Chuvashes these were *04 (28%), *11 (18%), *01 (16%), and *07 (16%). High frequencies of *11 (21%), *04 (17%), *01 (13%), and *04 (11%) specificities were characteristic of Komis, whereas Maris were distinguished by high frequencies of *01 (23%), *11 (14%), *07 (13%), and *04 (11%). In general, the pattern of DRB1 allelic polymorphism in populations of the Volga-Ural region, occupying the intermediate position between the Caucasoid- and Mongoloid-specific allelic frequency distribution patterns, was consistent with their anthropological type rather than with their linguistic affiliation.
authors.affiliation: Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia.
authors.forename: I M
authors.initials: IM
authors.lastname: Khidiiatova
authors.forename: A T
authors.initials: AT
authors.lastname: Ishmukhametova
authors.forename: G I
authors.initials: GI
authors.lastname: Lukmanova
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
mesh_terms: D005006:Ethnicity; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D011110:Polymorphism, Genetic; D012426:Russia
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains