Reovirus type 2 isolated from cerebrospinal fluid.
An 8-week-old female infant presented with a history of active varicella complicated by Escherichia coli sepsis, oral thrush, hypoalbuminemia, intermittent fevers, diarrhea and feeding intolerance. Rhesus monkey kidney cells inoculated with cerebrospinal fluid revealed reovirus-like particles by electron microscopy. Virus neutralization and RNA-gel electrophoresis studies identified the isolated pathogen as reovirus serotype 2. This report represents one of only a few to isolate reovirus from the central nervous system in humans.
Hermann
Laura
L
Department of Medical Microbiology and Infectious Disease, University of Manitoba, 511-730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada.
Embree
Joanne
J
Hazelton
Paul
P
Wells
Barbara
B
Coombs
R T Kevin
RT
D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D007223:Infant; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D030102:Orthoreovirus, Mammalian / Q000302:isolation & purification*; D012088:Reoviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D018570:Risk Assessment; D012720:Severity of Illness Index