title: A local approach to reduce industrial uranium wound contamination in rats.
abstract: The aim of this work is to develop a new approach to partially decontaminate wounds after industrial uranium contamination, during the interval of time between contamination and transfer of the patient to the infirmary. A wound dressing and a paste mixed or not with uranium-chelating ligands, ethane-1-hydroxy-1,1-bisphosphonate (EHBP) and carballylic amido bis phosphonic acid (CAPBP), were tested in vitro on muscles and in vivo on rats after deposit of uranium oxide compounds. The dressing and the paste, composed of carboxymethylcellulose-based hydrocolloids known to be highly absorbent, were applied on simulated wounds a few minutes after the contamination. The incorporation of chelating ligands did not improve the efficacy of the dressing or paste, and the best results were obtained with the dressing. In vivo, after 1 h of contact with the wound, the dressing absorbed about 30% and 60% of a UO4 compound deposited intra- and intermuscularly, respectively. After intramuscular deposit, the efficacy of the dressing was not reduced if the contact time decreased from 1 h to 15 min. Therefore, this wound dressing could be a practical option to treat uranium-contaminated wounds, but its efficacy depends on the localization of the uranium deposit.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Départment de Protection de las santé de l'Homme et Dosimétrie, Laboratoire d'Etudes Appliquées en Radiotoxicologie, BP 166, 26702 Pierrelatte, France. pascale.houpert@irsn.fr
authors.forename: P
authors.initials: P
authors.lastname: Houpert
authors.forename: V
authors.initials: V
authors.lastname: Chazel
authors.forename: F
authors.initials: F
authors.lastname: Paquet
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001458:Bandages; D002417:Cattle; D002614:Chelating Agents / Q000737:chemistry; D003666:Decontamination / Q000379:methods*; D004164:Diphosphonates / Q000737:chemistry; D066298:In Vitro Techniques; D007273:Injections, Intramuscular; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000293:injuries; D009824:Ointments; D063065:Organophosphonates / Q000627:therapeutic use; D010087:Oxides / Q000737:chemistry / Q000633:toxicity; D011848:Radioactive Pollutants / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D017974:Uranium Compounds / Q000737:chemistry / Q000633:toxicity; D014947:Wounds and Injuries
chemical_list: D002614:Chelating Agents; D004164:Diphosphonates; D009824:Ointments; D063065:Organophosphonates; D010087:Oxides; D011848:Radioactive Pollutants; D017974:Uranium Compounds; C409217:ethane-1-hydroxy-1,1-bisphosphonate; C114698:uranium peroxide; C054287:uranium octoxide; C012597:uranium dioxide