title: Lipid rafts as organizing platforms for cell chemotaxis and axon guidance.
abstract: Lipid rafts are thought to serve as plasma membrane platforms for localized trafficking and signaling. Recent findings reported by Guirland et al. in this issue of Neuron and by Gómez-Moutón in a recent issue of JCB support a direct role of lipid microdomains in organizing spatial signaling during axon guidance and cell chemotaxis by concentrating the gradient-sensing machinery at the leading edge.
authors.affiliation: Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institute, S-17177 Stockholm, Sweden.
authors.forename: Carlos F
authors.initials: CF
authors.lastname: Ibáñez
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002633:Chemotaxis / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014981:Xenopus