title: Postmarketing surveillance of the safety of cimetidine: 15-year mortality report.
abstract: The pattern of mortality after 15 years of observation is reported among almost 10,000 patients who were taking cimetidine when they were first recruited between 1977 and 1980. Many took the drug for a number of years, some switching to other antisecretory agents as the study progressed. The findings are reassuring and provide no evidence of any long-term adverse effects of cimetidine which might be detected by monitoring mortality rates. The data have also been used to examine the possible positive relationships between aluminium ingestion and Alzheimer's disease and H. pylori infection and ischaemic heart disease. No significant evidence was obtained in support of the existence of these relationships.
authors.affiliation: The Statwood Partnership, Hitchin, Herts, UK.
authors.forename: J
authors.initials: J
authors.lastname: Beresford
authors.forename: D G
authors.initials: DG
authors.lastname: Colin-Jones
authors.forename: A C
authors.initials: AC
authors.lastname: Flind
authors.forename: M J
authors.initials: MJ
authors.lastname: Langman
authors.forename: D H
authors.initials: DH
authors.lastname: Lawson
authors.forename: R F
authors.initials: RF
authors.lastname: Logan
authors.forename: K R
authors.initials: KR
authors.lastname: Paterson
authors.forename: M P
authors.initials: MP
authors.lastname: Vessey