Serum enzymes associated with cholestasis.
Alkaline phosphatase, gamma-glutamyl transferase, and 5' nucleotidase are the most common enzymes used in the evaluation of cholestasis. The present knowledge of these enzymes including their function, activity measurement, biologic variables of enzyme activity in healthy persons and disease states, and clinical significance are reviewed. Usefulness of enzymes patterns for diagnosis of specific cholestatic disorders and future directions in evaluation of cholestasis are also discussed.
Sotil
Eva U
EU
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Rush-Presbyterian-St. Luke's Medical Center, 1725 W. Harrison Street, Chicago, IL 60612, USA. eurtasun@rcn.com
Jensen
Donald M
DM
D000469:Alkaline Phosphatase / Q000502:physiology*; D002779:Cholestasis / Q000201:enzymology*; D006801:Humans; D009708:Nucleotidases / Q000502:physiology*; D005723:gamma-Glutamyltransferase / Q000502:physiology*
D005723:gamma-Glutamyltransferase; D009708:Nucleotidases; D000469:Alkaline Phosphatase; C030287:nucleotidase