[Adrenergic beta-receptor blockers--a group of chiral drugs: enantioseparation in the group of beta-blockers].
The preparation of pure individual enantiomers represents a topical problem from the standpoint of efficacy and safety of drugs. This paper continues in the preceeding review of the blockers of beta-adrenergic receptors as a group of chiral drugs, which is concerned with different pharmacodynamic, pharmacokinetic, and toxicological effects of individual enantiomers of this group. The review paper pays attention to the problems of enantioseparation of this group of chiral drugs, listing individual examples of the methods of enantioseparation, such as crystallization, biocatalysis, chromatographic methods (HPLC, GC, TLC), capillary electrophoresis, and the method of nuclear magnetic resonance (NMR). The individual methods of enantioseparation including enantioseparation in biological material (urine, serum) are illustrated on examples on beta-blockers used in clinical practice (e.g., propranolol, atenolol, metoprolol) as well as potential agents of this group of drugs.
Cizmáriková
R
R
Katedra chemickej teórie lieciv Farmaceutickej fakulty Univerzity Komenského, Bratislava. cizmarikova@fpharm.uniba.sk
Valentová
J
J
Hutta
J A
JA
D000319:Adrenergic beta-Antagonists / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods
D000319:Adrenergic beta-Antagonists