title: Differences in preparative loadability between the charged and uncharged forms of ionizable compounds.
abstract: Ionizable compounds experience a drastic difference in preparative loadability as a function of pH. It can be shown that the preparative loadability of a compound in the ionic form is by a factor of 20 or more inferior to the loadability of the same compound in the unionized form. In this paper, we demonstrate the reason for this behavior, and show practical applications of the principle.
authors.affiliation: Waters Corporation, 34 Maple Street, Milford, MA 01757, USA. uwe_neue@waters.com
authors.forename: Uwe Dieter
authors.initials: UD
authors.lastname: Neue
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Wheat
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Mazzeo
authors.forename: Cecilia B
authors.initials: CB
authors.lastname: Mazza
authors.forename: Jie Y
authors.initials: JY
authors.lastname: Cavanaugh
authors.forename: Fang
authors.initials: F
authors.lastname: Xia
authors.forename: Diane M
authors.initials: DM
authors.lastname: Diehl
mesh_terms: D000327:Adsorption; D006863:Hydrogen-Ion Concentration; D007477:Ions
chemical_list: D007477:Ions