Two new diterpenoids from Ballota limbata.
Two new clerodane-type diterpenoids trivially named as ballotenic acid (1) and ballodiolic acid (2) have been isolated from Ballota limbata along with three the known compounds; beta-amyrin, oleanolic acid, and beta-sitosterol. The structure elucidation of the new compounds was based primarily on two-dimensional (2D)-NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect (NOE) experiments. Compounds 1 and 2 displayed inhibitory potential against lipoxygenase enzyme in a concentration-dependent fashion with IC(50) values of 99.6 microM and 38.3 microM, respectively.
Ahmad
Viqar Uddin
VU
International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan. vuahmad@cyber.net.pk
Farooq
Umar
U
Hussain
Javid
J
Ullah
Farman
F
Nawaz
Sarfraz Ahmad
SA
Choudhary
Muhammad Iqbal
MI
D031329:Ballota / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045785:Diterpenes, Clerodane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D004224:Diterpenes; D045785:Diterpenes, Clerodane; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors; C493026:ballodiolic acid; C493025:ballotenic acid