[Recent advances in gene change of pancreatic cancer].
A large number of data derived from molecular analyses support the hypothesis that human cancer is a genetic disease and a distinct subset of genes have been found to be genetically changed in most tumors. Molecular alterations in pancreatic cancer include: (1) oncogenes such as K-ras, c-myc, c-fos, and c-erbB-2; (2) tumor suppressor genes such as p53, p16, DPC4/SMAD4, and DCC; and (3) growth factors such as EGF, FGF, HGF, PDGF, VEGF, TGF-beta. Genetic alterations of K-ras and p53 are common in human pancreatic cancer, but the occurrence of pancreatic cancer is a multi-step phenomenon in which the accumulation of genetic changes is extremely important.
Wang
Yu-yue
YY
Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. wangyuyue2002@yahoo.com
Cui
Quan-cai
QC
D004815:Epidermal Growth Factor / Q000235:genetics; D005346:Fibroblast Growth Factors / Q000235:genetics; D016147:Genes, Tumor Suppressor; D016259:Genes, myc / Q000235:genetics; D019942:Genes, p16; D016158:Genes, p53 / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics*
D006133:Growth Substances; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor