Nonlinear photodynamic therapy. Photochemical dose levelling within a tumor by saturating a photosensitizer's triplet states.
The photodynamic therapy involving saturation of triplet state of a photosensitizer by short high-energy light pulses was studied theoretically. The possibility of creating a uniform therapeutic dose distribution throughout a large tumor using both surface and interstitial irradiation is shown. Possible thickness of the treated tissue layer and the required duration of the PDT session are estimated.
Kogan
Boris Ya
BY
State Research Center of the Russian Federation, Research Institute of Organic Intermediates and Dyes, 1 ul. B. Sadovaya, 123995 Moscow, Russian Federation. kogan@dic.ru
D007700:Kinetics; D008962:Models, Theoretical; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
D017319:Photosensitizing Agents