Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide.
Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide (PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY). Whereas their roles in regulation of gastrointestinal function have been known for some time, it is now evident that they also influence eating behavior. This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans.
Stanley
Sarah
S
Endocrine Unit, Imperial College Faculty of Medicine, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK.
Wynne
Katie
K
Bloom
Steve
S
D004064:Digestive System / Q000378:metabolism*; D005934:Glucagon / Q000502:physiology*; D052216:Glucagon-Like Peptide 1; D004763:Glucagon-Like Peptides / Q000502:physiology*; D006801:Humans; D053772:Oxyntomodulin; D010191:Pancreatic Polypeptide / Q000502:physiology*; D010446:Peptide Fragments / Q000502:physiology*; D019894:Peptide YY / Q000502:physiology*; D011498:Protein Precursors / Q000502:physiology*; D012528:Satiety Response / Q000502:physiology*; D015398:Signal Transduction
D053772:Oxyntomodulin; D010446:Peptide Fragments; D011498:Protein Precursors; D019894:Peptide YY; D010191:Pancreatic Polypeptide; D004763:Glucagon-Like Peptides; D052216:Glucagon-Like Peptide 1; D005934:Glucagon