title: Correction for partial volume errors in MR heart perfusion imaging.
abstract: Myocardial MR first-pass perfusion time courses are contaminated by signals from the ventricles (spillover) as a consequence of partial volume effects and motion. An early increase in the signal intensity from the myocardium is an indicator of contamination. This contamination leads to under- or overestimation of perfusion, depending on the amount of contamination. In this work a simple method for contamination correction is proposed: curves proportional to the signal intensity time courses in the ventricles are subtracted from the signal intensity time courses in the myocardium to minimize the variance of signal before the arrival of the contrast medium in the myocardium. The proposed correction is easy to apply, removes the contamination, and leads to more precise perfusion values.
authors.affiliation: Institut für Röntgendiagnostik, Universität Würzburg, Germany. koestler@roentgen.uni-wuerzburg.de
authors.forename: Herbert
authors.initials: H
authors.lastname: Köstler
authors.forename: Christian
authors.initials: C
authors.lastname: Ritter
authors.forename: Martin
authors.initials: M
authors.lastname: Reiss-Zimmermann
authors.forename: Meinrad
authors.initials: M
authors.lastname: Beer
authors.forename: Dietbert
authors.initials: D
authors.lastname: Hahn
authors.forename: Jörn
authors.initials: J
authors.lastname: Sandstede
mesh_terms: D016477:Artifacts; D002306:Cardiac Volume / Q000502:physiology*; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009206:Myocardium; D010496:Pericardium / Q000502:physiology; D013382:Subtraction Technique; D013997:Time Factors; D016276:Ventricular Function
chemical_list: D003287:Contrast Media