Synthesis of 9-membered dilactams derived from 1,3-diaminopropionic and glutamic acids.
Previously unknown 9-membered bridged dipeptides derived from l or d isomers of 1,3-diaminopropionic acids and l-glutamic acid were synthesized using aminoacyl incorporation reaction. Key intermediates containing internal pyroglutamyl moiety were prepared via side chain to backbone cyclization of related protected dipeptide derivatives of glutamic acid.
Chulin
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Laboratory of Peptide Chemistry, Branch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino, Moscow, Russia.
Rodionov
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Ivanov
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VT
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D004151:Dipeptides / Q000138:chemical synthesis*; D018698:Glutamic Acid / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis*; D015394:Molecular Structure; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000737:chemistry*
D004151:Dipeptides; D007769:Lactams; D015091:beta-Alanine; D018698:Glutamic Acid; C011757:2,3-diaminopropionic acid