Insulin resistance and changes in plasma concentration of TNFalpha, IGF1, and NEFA in dogs during weight gain and obesity.
Obesity-induced insulin resistance (IR) is a common problem in humans as well as domestic dogs. It is well-known that this syndrome is associated with many modifications but it is still unclear if the changes are alterations or adaptations. The purpose of this study was to develop obesity-induced IR in dogs, through a long-term overfeeding period, and to explore hormonal and metabolic disturbances associated with the development of this syndrome. Dogs were overfed for 7 months. Body weight increased by 43 +/- 5%, and insulin sensitivity decreased by 44 +/- 5%. Plasma insulin-like growth factor 1 (IGF1), tumour necrosis factor alpha (TNFalpha), and non-esterified fatty acids (NEFA) concentrations progressively increased during the overfeeding period (IGF1: 111 +/- 13 to 266 +/- 32 ng/ml, p < 0.001; TNFalpha: 5 +/- 5 to 134 +/- 41 pg/ml; NEFA: 0.974 +/- 0.094 to 1.590 +/- 0.127 mmol/l, p < 0.05). These metabolic and hormonal impairments are associated with IR, in obese dogs, and could explain, at least in part, the outbreak of this syndrome.
Gayet
C
C
USC INRA de Nutrition et Endocrinologie, Ecole Nationale Vétérinaire de Nantes, Nantes, France.
Bailhache
E
E
Dumon
H
H
Martin
L
L
Siliart
B
B
Nguyen
P
P
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004283:Dog Diseases / Q000097:blood* / Q000503:physiopathology; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D015309:Glucose Clamp Technique / Q000662:veterinary; D006946:Hyperinsulinism / Q000097:blood / Q000662:veterinary; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D019518:Postprandial Period / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D015430:Weight Gain / Q000502:physiology
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha; D007334:Insulin-Like Growth Factor I