Jusbetonin, the first indolo[3,2-b]quinoline alkaloid glycoside, from Justicia betonica.
A new indolo[3,2-b]quinoline alkaloid glycoside, jusbetonin (1), and three known alkaloids, namely, 10H-quindoline (2), 6H-quinindoline (3), and 5H,6H-quinindolin-11-one (4), have been isolated from the leaves of Justicia betonica. The structure of 1 was established on the basis of 1D and 2D NMR ((1)H-(1)H COSY, HMQC, and HMBC) and HRFABMS data. Compound 1 is the first example of a glycosylated indolo[3,2-b]quinoline alkaloid, while compound 4 was isolated for the first time from a natural source.
Subbaraju
Gottumukkala V
GV
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India. subbaraju@nettlinx.com
Kavitha
Jakka
J
Rajasekhar
Dodda
D
Jimenez
Jorge I
JI
D027901:Acanthaceae / Q000737:chemistry*; D007194:India; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification*; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification*
C484922:5H,6H-quinindolin-11-one; D026121:Indole Alkaloids; D011804:Quinolines; D015363:Quinolones; C484921:jusbetonin