[Modern aspects in morphogenesis of breast cancer].
The development of tumor process takes place in synchronization of interaction of parenchymatous and stromal components at the molecular level. This is confirmed by the capacity of breast cancer cells to synthesize both endotheliocytes and endothelin-1. Vascular and nervous components of the communicative systems also participate in morphogenesis of breast cancer. The study of epithelial-stromal interaction at the molecular level may become one of basic diagnostic criteria.
Zolotova
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EN
Smolensk Regional Institute of Pathology, 214018, Smolensk.
Dorosevich
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AE
D001943:Breast Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2