title: Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.
abstract: Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. gaby.neu-yilik@med.uni-heidelberg.de
authors.forename: Gabriele
authors.initials: G
authors.lastname: Neu-Yilik
authors.forename: Niels H
authors.initials: NH
authors.lastname: Gehring
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Hentze
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Kulozik
mesh_terms: D000818:Animals; D018389:Codon, Nonsense / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
chemical_list: D018389:Codon, Nonsense; D012333:RNA, Messenger