Chromosomal insertion involving MLL in childhood acute myeloblastic leukemia (M4).
Recurrent chromosomal rearrangements involving the 11q23 region have been described in various hematologic malignancies. Among these rearrangements, translocations are the most common mechanism involving the mixed lineage leukemia gene (MLL). Few cases of insertion have been reported and, to our knowledge, none of them involved MLL and chromosome 1. We report a complex karyotype in a childhood acute myelomonocytic leukemia (AML M4) involving the 11q23 region with an insertion between chromosomes 1 and 11 in addition to a translocation between chromosomes 11 and 22. This translocation was clarified by fluorescence in situ hybridization (FISH) analysis: 46,XY,ins(1;11)(q22 approximately q23;q13q23),t(11;22)(q13;q11 approximately q12). This finding also underlines the complementary contribution of conventional cytogenetic and FISH analysis to detect karyotypic complex abnormalities.
Lafay-Cousin
Lucie
L
INSERM Unité 524, Institut de Recherches sur le Cancer de Lille, 1 place de Verdun, 59000 Lille Cedex, France.
Soenen
Valérie
V
Mazingue
Françoise
F
Preudhomme
Claude
C
Laï
Jean-Luc
JL
Andrieux
Joris
J
D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male
D004251:DNA Transposable Elements