title: Increase of serum interleukin-10 in intractable Graves' disease.
abstract: The intractability of Graves' disease (GD) and the severity of Hashimoto's disease (HD) vary among patients. We previously reported that peripheral immunoglobulin (Ig) G3-secreting cells were increased in patients with intractable GD (i.e., requiring continuous antithyroid drug therapy). Isotype switching to IgG3 is induced by interleukin (IL)-4 and IL-10. To clarify which of these cytokines is related to the intractability or severity of autoimmune thyroid disease (AITD), we examined the serum concentrations of IL-10 and IL-4 by enzyme immunoassay in 166 patients with AITD and in 53 healthy controls. The serum IL-10 concentration was significantly higher in patients with GD and continuously positive for thyrotropin (TSH) receptor antibody (TRAb) despite more than 5 years of antithyroid drugs treatment than in patients with GD in remission. The serum IL-4 concentration did not differ between these two groups of patients. However, the serum IL-10 concentration was not related to the severity of HD. These results indicate that IL-10, but not IL-4, is related to the intractability of GD, but not to the severity of HD.
authors.affiliation: Division of Biomedical Informatics, Course of Health Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Takeoka
authors.forename: Mikio
authors.initials: M
authors.lastname: Watanabe
authors.forename: Fumio
authors.initials: F
authors.lastname: Matsuzuka
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Iwatani
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D013956:Antithyroid Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D004334:Drug Administration Schedule; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011989:Receptors, Thyrotropin / Q000276:immunology; D012074:Remission Induction; D012720:Severity of Illness Index; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000503:physiopathology
chemical_list: D000906:Antibodies; D013956:Antithyroid Agents; D011989:Receptors, Thyrotropin; D016753:Interleukin-10; D015847:Interleukin-4