title: [Primary research of development of a mouse model for non-bacterial sialoadenitis]
abstract: OBJECTIVE: To develope a mouse model for non-bacterial sialoadenitis similar to SS.The model of organ-specific to the submandibular gland of mouse has developed for this study. METHODS: Several of the mouse strains were used to the development of non-bacterial sialoadenitis.The injection of syngeneic salivary gland tissue with CFA induced inflammation in submandibular gland in mice.Not all mice had a predictable response. RESULTS: C(57) mice (500microg/ml and 750microg/ml group )appear histologically to be more prove to develop sialoadenitis. CONCLUSION: An animal model of non-bacterial sialoadenitis had been set up,the non-bacterial sialoadentitis may be similar to the autoimmune process in human SS.
authors.affiliation: Department of Oral and Maxillofacial Surgery,School of Stomatology,Shanghai Second Medical University.Shanghai 200011, China.
authors.forename: C Q
authors.initials: CQ
authors.lastname: Yu
authors.forename: W L
authors.initials: WL
authors.lastname: Qiu
authors.forename: B P
authors.initials: BP
authors.lastname: Hu
authors.forename: Y M
authors.initials: YM
authors.lastname: Ding