title: Solvent-drop grinding: green polymorph control of cocrystallisation.
abstract: By grinding with a minimal addition of a solvent of appropriate polarity, control over the polymorphic outcome of a novel cocrystallisation involving the model pharmaceutical compound caffeine may be achieved.
authors.affiliation: Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Andrew V
authors.initials: AV
authors.lastname: Trask
authors.forename: W D Samuel
authors.initials: WD
authors.lastname: Motherwell
authors.forename: William
authors.initials: W
authors.lastname: Jones
mesh_terms: D002110:Caffeine / Q000737:chemistry; D003460:Crystallization; D005977:Glutarates / Q000737:chemistry; D015394:Molecular Structure; D019999:Pharmaceutical Solutions / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D005977:Glutarates; D019999:Pharmaceutical Solutions; D012997:Solvents; D002110:Caffeine; C035736:glutaric acid