title: Slow growth of benign thyroid nodules after menopause: no need for long-term thyroxine suppressive therapy in post-menopausal women.
abstract: Benign thyroid nodules represent a very common disorder, the management of which is still controversial. The aim of the present work was to evaluate by ultrasound examination the volume changes of thyroid nodules in post-menopausal women presenting single palpable nodular goiter of recent onset (less than 6 months from diagnosis). Forty-three patients received L-T4-treatment, 38 represented the no-treatment group. Long-term follow up (3 and 5 yr) did not show any significant change in the mean volume nodule in these patients. In the no-treatment group, the mean nodule volumes were stable over time from baseline to 5 yr. No significant difference was observed at any follow-up evaluation between thyroid hormone treated and untreated patients. After 1 yr of treatment, a significant decrease (p = 0.0275) in mean nodule volume occurred only for nodules with a baseline volume lower than 1.5 ml. The frequency of clinically relevant nodule size variation showed a more frequent decrease (13.9%) at 1 yr in the L-T4 group, as compared to the no-treatment group (2.6%), while the proportion of increased volume at 1 yr was higher in the untreated than in the L-T4 group (5.3% vs 2.3%). This inverse relationship between the 2 groups was not statistically significant (p = 0.076). In conclusion, an arrest in the growth of benign thyroid nodules occurs in the majority of women after menopause. Only a very limited number of these patients may benefit from thyroid hormone suppressive treatment.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Catanzaro, Catanzaro, Italy. costante@unicz.it
authors.forename: G
authors.initials: G
authors.lastname: Costante
authors.forename: U
authors.initials: U
authors.lastname: Crocetti
authors.forename: E
authors.initials: E
authors.lastname: Schifino
authors.forename: O
authors.initials: O
authors.lastname: Ludovico
authors.forename: C
authors.initials: C
authors.lastname: Capula
authors.forename: M
authors.initials: M
authors.lastname: Nicotera
authors.forename: F
authors.initials: F
authors.lastname: Arturi
authors.forename: S
authors.initials: S
authors.lastname: Filetti
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D006044:Goiter, Nodular / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood / Q000502:physiology*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013960:Thyroid Function Tests; D016606:Thyroid Nodule / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D013974:Thyroxine