A case of lactic acidosis caused by stavudine in an AIDS patient.
Nucleoside reverse transcriptase inhibitors (NRTIs), which are used for the treatment of human immunodeficiency virus (HIV) infection have been associated with a wide spectrum of clinical manifestations, including hepatic steatosis, lipodystrophy, myopathy, and lactic acidosis. Such adverse effects are postulated to result from the inhibition of mitochondrial DNA gamma polymerase, which causes the depletion of mitochondrial DNA and eventual the disruption of oxidative phosphorylation. Although cases of severe decompensated lactic acidosis are rare, this syndrome is associated with a high mortality rate. We report upon the first Korean case, of severe lactic acidosis in an acquired immunodeficiency syndrome (AIDS) patient receiving stavudine, an anti-HIV drug.
Cho
Byoung Chul
BC
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Han
Sang Hoon
SH
Choi
Suk Hoon
SH
Choi
Jun Yong
JY
Chang
Kyung Hee
KH
Song
Young Goo
YG
Kim
June Myung
JM
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D018119:Stavudine / Q000009:adverse effects* / Q000627:therapeutic use
D019380:Anti-HIV Agents; D017693:Sodium Bicarbonate; D018119:Stavudine