title: The relationship between the serum intercellular adhesion molecule-1 level and the prognosis of the disease in lung cancer.
abstract: BACKGROUND
  Adhesion molecules are related to cell-to-cell interaction and inflammatory interaction. In addition, adhesive interactions between tumor cells and adjacent cells and/or extracellular matrix play important roles in the complex process of tumor growth and development. Among these adhesion molecules, expression of intercellular adhesion molecule-1 (ICAM-1) has been identified in colon cancer, bladder cancer, lung cancer, melanoma, pancreatic cancer and hepatocellular carcinoma. In the current study, we analyzed serum ICAM-1 concentrations to investigate the relationship between the serum ICAM-1 level and prognosis in patients with lung cancer.
  
  
  METHODS
  Serum ICAM-1 was measured in 84 patients with lung cancer according to the pathologic type and clinical stage using the ICAM-1 ELISA kit. The Kaplan-Meier method was used to analyse survival time.
  
  
  RESULTS
  There was no difference in serum ICAM-1 concentration among the different stages of lung cancer. Furthermore, there was no difference observed between histologic tumor type with regard to serum ICAM-1 concentration. Although the difference was not significant, the overall survival times of patients with a low serum ICAM-1 concentration (< 306 ng/mL) was longer than that of patients with a high concentration (> or = 306 ng/mL) in non-small cell lung cancer patients.
  
  
  CONCLUSIONS
  These results suggest that high levels of serum ICAM-1 reflect poor prognosis for patients with non-small cell lung cancer.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Hun Sub
authors.initials: HS
authors.lastname: Shin
authors.forename: Chan Hee
authors.initials: CH
authors.lastname: Jung
authors.forename: Hyun Duk
authors.initials: HD
authors.lastname: Park
authors.forename: Seung Sei
authors.initials: SS
authors.lastname: Lee
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000401:mortality / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000097:blood* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D018799:Intercellular Adhesion Molecule-1