Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nuclear magnetic resonance analyses of end-functionalized saccharidic polymers: an example of a useful analytical technique combination.
The living cationic polymerization of a saccharidic monomer (1,2:3,4-di-O-isopropylidene-6-O-(2-vinyloxyethyl)-D-galactopyranose, GVE) gives rise to aldehyde end-capped polymers (PGVE--CHO) of low molar masses (<10 000 Da) and low molar mass distribution (<1.2). These polymers were derivatized by selective introduction of either hexamethylenediamine (PGVE-NH2) or 9-fluorenylmethyl carbazate (PGVE-Fmoc) end groups. The resulting polymers were fully characterized by complementary use of nuclear magnetic resonance (1H NMR) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS). The expected structure according to the polymerization mechanism, the occurrence of side reactions and the success of the post-functionalization reactions were confirmed.
D'Agosto
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F
LCPP CPE/CNRS 43 boulevard du 11 novembre 1918, Bat 308F, BP2077 69 616, Villeurbanne, France.
Charreyre
M T
MT
Pichot
C
C
Dessalces
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G
Delolme
F
F
D002623:Chemistry Techniques, Analytical / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011134:Polysaccharides / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
D011134:Polysaccharides