[Inflammation and Parkinson's disease].
Parkinson's disease is a neurodegenerative disorder associated with aging characterized by a motor extrapiramidal alteration secondary to the progressive death of dopaminergic neurons of the substantia nigra pars compacta. The cause of this neuronal loss remains unknown but post mortem studies on brains of parkinsonian patients showed high index of inflammatory mechanism markers. This point has gone to open new lines of research in order to ascertain what role have these inflammatory process in neuronal degeneration and has opened new therapeutic possibilities to stop or at least to brake the neurodegenerative process.
Barcia González
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Departamento de Anatomía Humana y Psicobiología, Facultad de Medicina, Universidad de Murcia, Murcia, España. barcia@um.es
Herrero Ezquerro
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D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000378:metabolism; D000818:Animals; D015415:Biomarkers; D002560:Cerebrovascular Circulation / Q000502:physiology; D016207:Cytokines / Q000378:metabolism; D015259:Dopamine Agents / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000628:therapy
D015415:Biomarkers; D016207:Cytokines; D015259:Dopamine Agents; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine