Stopping and going with p27kip1.
Nuclear p27kip1 is an established inhibitor of cyclin-dependent kinase-2, and it now appears that cytoplasmic p27kip1 inhibits the activation of RhoA. In this dual role, p27kip1 could coordinate cell cycle progression and cell migration.
Assoian
Richard K
RK
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
D000818:Animals; D042846:CDC2-CDC28 Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement / Q000235:genetics*; D051357:Cyclin-Dependent Kinase 2; D051358:Cyclin-Dependent Kinase 4; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism; D025461:Feedback, Physiological / Q000235:genetics; D006801:Humans; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D018797:Cell Cycle Proteins; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; C495900:CDK4 protein, human; D051357:Cyclin-Dependent Kinase 2; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases; D020742:rhoA GTP-Binding Protein