title: Gout: a clinical and radiologic review.
abstract: Gout is a group of diseases characterized by arthritis and results from a disturbance of urate metabolism with the deposition of monosodium urate crystals in the joints and soft tissues. Often, but not invariably, the serum urate levels are elevated as a result of overproduction or underexcretion of uric acid. Clinical manifestations include acute and chronic arthritis, tophaceous deposits, interstitial renal disease, and uric acid nephrolithiasis. The diagnosis is based on the identification of uric acid crystals in joints, tissues, or body fluids. Acute episodes are treated with colchicine, NSAIDs, or steroids. Long-term management includes treatment with uricosuric agents or xanthine oxidase inhibitors.
authors.affiliation: Department of Musculoskeletal Radiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA. johnny_monu@urmc.rochester.edu
authors.forename: Johnny U V
authors.initials: JU
authors.lastname: Monu
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Pope
mesh_terms: D000328:Adult; D000367:Age Factors; D015210:Arthritis, Gouty / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000175:diagnosis; D003078:Colchicine / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006073:Gout / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000175:diagnosis; D015995:Prevalence; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D014528:Uricosuric Agents / Q000627:therapeutic use; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
chemical_list: D006074:Gout Suppressants; D014528:Uricosuric Agents; D014969:Xanthine Oxidase; D003078:Colchicine