Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?
The cyclic nucleotide cyclic di-guanosine-monophosphate (c-diGMP) was recognized in the 1980s as a signaling compound that is involved in controlling the condensation of glucose moieties into cellulose polymers. More recent data from several different bacterial species now suggest that c-diGMP might have a general role as secondary messenger in modulating bacterial growth on surfaces by regulating cellular adhesion components and preparing cells for cell-cell and cell-surface interactions.
Jenal
Urs
U
Division of Molecular Microbiology, Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. urs.jenal@unibas.ch
D001419:Bacteria / Q000378:metabolism*; D001422:Bacterial Adhesion / Q000502:physiology; D001426:Bacterial Proteins / Q000378:metabolism; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*
D001426:Bacterial Proteins; D008565:Membrane Proteins; C062025:bis(3',5')-cyclic diguanylic acid; D006152:Cyclic GMP