Altered fractionated radiotherapy in the management of head and neck carcinomas: advantages and limitations.
OBJECTIVE
This article provides an overview of randomized studies of altered fractionated radiotherapy (RT) in Head and Neck squamous cell carcinoma.


RESULTS
Both hyperfractionated RT and accelerated RT may improve tumor control probability as compared to conventional RT, along with increased but manageable toxicity and a modest improvement in survival.


CONCLUSIONS
Altered RT is a tool that can improve the results obtained with conventional RT in Head and squamous cell carcinoma.
Bourhis
Jean
J
Institut Gustave Roussy, Radiation Oncology & Statistic Departments, Villejuif, France. bourhis@igr.fr
Etessami
Atoussa
A
Wilbault
Pierre
P
Lusinchi
Antoine
A
Calais
Gilles
G
Lapeyre
Michel
M
Pignon
Jean Pierre
JP
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D019468:Disease Management; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D015996:Survival Rate