title: Anticonvulsant activity of Schiff bases of isatin derivatives.
abstract: Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.
authors.affiliation: Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi-221005, India.
authors.forename: Manjusha
authors.initials: M
authors.lastname: Verma
authors.forename: Surendra Nath
authors.initials: SN
authors.lastname: Pandeya
authors.forename: Krishna Nand
authors.initials: KN
authors.lastname: Singh
authors.forename: James P
authors.initials: JP
authors.lastname: Stables
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D003292:Convulsants; D004597:Electroshock; D005260:Female; D007510:Isatin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D020258:Neurotoxicity Syndromes / Q000503:physiopathology; D010433:Pentylenetetrazole; D004856:Postural Balance / Q000187:drug effects; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D012545:Schiff Bases; D007510:Isatin; D010433:Pentylenetetrazole