Noncanonical peptides in complex with MHC class I.
The major histocompatibility complex (MHC) presents canonical medium-high-affinity peptides on the surface of antigen-presenting cells to T-cells. Recognition of peptide MHC by T-cells initiates a cascade of signals which maintains a T-cell-dependent immune response. In the design of vaccines, there is need for an understanding of how peptides bind to MHC class I molecules. Herein, the presentation of canonical anchor motif peptides to MHC class I, noncanonical anchor motif peptides, low-affinity peptides, peptides making use of new pockets, short peptides, long peptides, glycopeptides, retro-inverso peptides and prediction programs for peptides binding to MHC class I molecules is discussed. All this information will aid in the design of new and improved peptide-based vaccines.
Apostolopoulos
Vasso
V
The Austin Research Institute, Immunology and Vaccine Laboratory, Studley Road, Heidelberg, VIC 3084, Australia. v.apostolopoulos@ari.unimelb.edu.au
Lazoura
Eliada
E
D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D022223:Vaccines, Subunit / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D010455:Peptides; D022223:Vaccines, Subunit