[Stinging nettle root extract (Bazoton-uno) in long term treatment of benign prostatic syndrome (BPS). Results of a randomized, double-blind, placebo controlled multicenter study after 12 months].
Phytotherapy of BPS has a long tradition in Germany; nevertheless, data referring to single phytotherapeutic agents are rare. We therefore performed a randomized, double-blind, placebo-controlled multicenter study for 1 year with Bazoton uno (459 mg dry extract of stinging nettle roots) with 246 patients. The IPSS decreased on average from 18.7+/-0.3 to 13.0+/-0.5 with a statistically significant difference compared to placebo (18.5+/-0.3 to 13.8+/-0.5; p=0.0233). The median Q(max) increased by 3.0+/-0.4 ml/s in comparison to 2.9+/-0.4 ml/s (placebo), thus not statistically significantly different, as well as the median volume of residual urine, which changed from 35.5+/-3.4 ml before therapy to 20.0+/-2.8 ml and from 40.0+/-4.0 ml to 21.0+/-2.9 ml under placebo application. The number of adverse events (29/38) as well as urinary infections etc. (3/10 events) was smaller under Bazoton uno therapy compared to placebo. Treatment with Bazoton uno can therefore be considered a safe therapeutic option for BPS, especially for reducing irritative symptoms and BPS-associated complications due to the postulated antiphlogistic and antiproliferative effects of the stinging nettle extract. A strong increase of Q(max) or reduction of residual urine are not to be expected.
Schneider
T
T
Klinik und Poliklinik für Urologie der Universitätsklinik Essen. tim.schneider@uni-essen.de
Rübben
H
H
D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D015990:Placebo Effect; D010936:Plant Extracts / Q000008:administration & dosage* / Q000627:therapeutic use; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D026982:Urtica dioica / Q000737:chemistry
D010936:Plant Extracts; C033043:Bazoton