The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle.
The ubiquitin proteasome system (UPS) contributes to the pathophysiology of neurodegenerative diseases, and it is also a major determinant of synaptic protein degradation and activity. Recent studies in rodents and in the fruit fly Drosophila have shown that the activity of the UPS is involved in axonal degeneration. Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders.
Korhonen
Laura
L
Dept. of Neuroscience, Unit of Neurobiology, Biomedical Centre, Box 587, Uppsala University, S-75123 Uppsala, Sweden.
Lindholm
Dan
D
D000818:Animals; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D023421:Models, Animal; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D017729:Presynaptic Terminals / Q000201:enzymology* / Q000473:pathology; D046988:Proteasome Endopeptidase Complex; D021381:Protein Transport / Q000235:genetics; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*; D014855:Wallerian Degeneration / Q000201:enzymology* / Q000235:genetics / Q000503:physiopathology
D009097:Multienzyme Complexes; D009419:Nerve Tissue Proteins; D025801:Ubiquitin; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex