Cytokines and liver failure: modification of TNF- and IL-6 in patients with acute on chronic liver decompensation treated with Molecular Adsorbent Recycling System (MARS).
Liver transplantation, considered today as the most effective treatment for end-stage liver diseases, can not always be performed on every patient affected with a liver disease. Patients with end-stage liver diseases, usually have high bilirubin, encephalopathy and renal failure. In these situations cytokines play an important role in different processes, from apoptosis to regeneration. The aim of this clinical study has been to analyse the action of new artificial liver system, called Molecular Adsorbent Recycling System (MARS) on cytokines metabolism in patients affected with acute on chronic liver failure. The results are intriguing because an increase of IL-6 and a decrease of TNF-alpha observed during MARS treatment. The study confirms the efficacy of MARS therapy in terms of homeostasis of the cytokines network and suggests an usefulness of monitoring their level during liver failure.
Ambrosino
Giovanni
G
Department of Surgery and Gastroenterological Science, Liver Transplant Unit, University of Padova, Padova, Italy.
Naso
Agostino
A
Feltracco
Paolo
P
Carraro
Paolo
P
Basso
Stefano M
SM
Varotto
Sergio
S
Cillo
Umberto
U
Zanus
Giacomo
G
Boccagni
Patrizia
P
Brolese
Alberto
A
Plebani
Mario
M
Giron
Giampiero
G
D'Amico
Davide F
DF
D000327:Adsorption; D000328:Adult; D001663:Bilirubin / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D017093:Liver Failure / Q000276:immunology / Q000378:metabolism* / Q000628:therapy*; D017114:Liver Failure, Acute / Q000378:metabolism / Q000628:therapy; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D001663:Bilirubin