[Comparative effectiveness of antioxidant melatonin and radioprotectors indralin and phenylephrine in local radiation injuries].
In experiments on mice radioprotective properties of indraline, phenyleprine and melatonin were compared at topical application as an ointment at a place of local exposure of animal hind to a dose of 38.3 Gy of 60Co gamma-quanta. Factor of dose reduction was 1.27-1.32 for indraline (1-10% ointment) and 1.29 for phenyleprine (0.25% ointment). Antioxidants were low efficient at radiation skin burn. At later local radiation injuries, such as hind contracture, the efficiency of indraline was 1.33-1.5, that of phenyleprine was 1.28, and that of melatonine (2 and 5% ointment) was 1.23-1.47.
Vasin
M V
MV
Institute of Military Medicine, Ministry of Deferense of Russian Federation, 126083 Russia.
Ushakov
I B
IB
Kovtun
V Iu
VIu
Komarova
S N
SN
Semenova
L A
LA
Galkin
A A
AA
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D003037:Cobalt Radioisotopes / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D005260:Female; D008550:Melatonin / Q000008:administration & dosage* / Q000627:therapeutic use; D051379:Mice; D008962:Models, Theoretical; D009824:Ointments; D010636:Phenols / Q000008:administration & dosage* / Q000627:therapeutic use; D010656:Phenylephrine / Q000008:administration & dosage* / Q000627:therapeutic use; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D011855:Radiodermatitis / Q000517:prevention & control*; D013997:Time Factors
D000975:Antioxidants; D003037:Cobalt Radioisotopes; D009824:Ointments; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; D010656:Phenylephrine; D008550:Melatonin