title: Coronalon: a powerful tool in plant stress physiology.
abstract: Coronalon, a synthetic 6-ethyl indanoyl isoleucine conjugate, has been designed as a highly active mimic of octadecanoid phytohormones that are involved in insect and disease resistance. The spectrum of biological activities that is affected by coronalon was investigated in nine different plant systems specifically responding to jasmonates and/or 12-oxo-phytodienoic acid. In all bioassays analyzed, coronalon demonstrated a general strong activity at low micromolar concentrations. The results obtained showed the induction of (i) defense-related secondary metabolite accumulation in both cell cultures and plant tissues, (ii) specific abiotic and biotic stress-related gene expression, and (iii) root growth retardation. The general activity of coronalon in the induction of plant stress responses together with its simple and efficient synthesis suggests that this compound might serve as a valuable tool in the examination of various aspects in plant stress physiology. Moreover, coronalon might become employed in agriculture to elicit plant resistance against various aggressors.
authors.affiliation: Max-Planck-Institut für Chemische Okologie, Hans-Knöll-Str. 8, D-07745 Jena, Germany.
authors.forename: Göde
authors.initials: G
authors.lastname: Schüler
authors.forename: Axel
authors.initials: A
authors.lastname: Mithöfer
authors.forename: Ian T
authors.initials: IT
authors.lastname: Baldwin
authors.forename: Susanne
authors.initials: S
authors.lastname: Berger
authors.forename: Jürgen
authors.initials: J
authors.lastname: Ebel
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Santos
authors.forename: Gabriele
authors.initials: G
authors.lastname: Herrmann
authors.forename: Dirk
authors.initials: D
authors.lastname: Hölscher
authors.forename: Robert
authors.initials: R
authors.lastname: Kramell
authors.forename: Toni M
authors.initials: TM
authors.lastname: Kutchan
authors.forename: Helmut
authors.initials: H
authors.lastname: Maucher
authors.forename: Bernd
authors.initials: B
authors.lastname: Schneider
authors.forename: Irene
authors.initials: I
authors.lastname: Stenzel
authors.forename: Claus
authors.initials: C
authors.lastname: Wasternack
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Boland
mesh_terms: D002478:Cells, Cultured; D003517:Cyclopentanes / Q000145:classification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D017343:Genes, Plant; D007532:Isoleucine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D015394:Molecular Structure; D054883:Oxylipins; D063245:Plant Development; D010937:Plant Growth Regulators / Q000494:pharmacology; D018521:Plant Physiological Phenomena; D018517:Plant Roots / Q000187:drug effects / Q000502:physiology; D010944:Plants / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D003517:Cyclopentanes; D005231:Fatty Acids, Unsaturated; D054883:Oxylipins; D010937:Plant Growth Regulators; C484935:coronalon; D007532:Isoleucine; C025999:12-oxophytodienoic acid; C086299:jasmone