title: New macroporous calcium phosphate glass ceramic for guided bone regeneration.
abstract: This work describes a method to obtain macroporous resorbable glass and glass ceramic scaffolds with controlled biodegradability for tissue engineering applications. The constructs consisted of glass and glass ceramics in the system P(2)O(5)-CaO-Na(2)O-TiO(2) and they were prepared by foaming a slurry of glass particles by addition of a H(2)O(2) solution, and subsequent sintering of the porous structures obtained. Different thermal treatments were applied to control the degree of devitrification of the glass. The resultant materials showed a porosity percentage between 40% and 55% with a wide variety of pores ranging from 20 to 500 microm in diameter as determined by SEM and Image Analysis. The resulting constructs were predominantly formed by a vitreous phase, although small amounts of calcium metaphosphate and pyrophosphates were detected by X-ray diffraction and Raman spectroscopy after the sintering process. The biological response was also evaluated by means of the MTT test, the material showed a non-cytotoxic effect.
authors.affiliation: Biomedical Engineering Research Center (CREB), Department of Materials Science and Metallurgy, Technical University of Catalonia, ETSEIB, Avda Diagonal 647, Barcelona 08028, Spain. melba.navarro@upc.es
authors.forename: Melba
authors.initials: M
authors.lastname: Navarro
authors.forename: Sergio
authors.initials: S
authors.lastname: del Valle
authors.forename: Salvador
authors.initials: S
authors.lastname: Martínez
authors.forename: Stefania
authors.initials: S
authors.lastname: Zeppetelli
authors.forename: Luigi
authors.initials: L
authors.lastname: Ambrosio
authors.forename: Josep Anton
authors.initials: JA
authors.lastname: Planell
authors.forename: Maria Pau
authors.initials: MP
authors.lastname: Ginebra
mesh_terms: D020341:Absorbable Implants; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival; D002516:Ceramics / Q000737:chemistry; D005898:Glass / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology; D010006:Osteoblasts / Q000166:cytology*; D016062:Porosity; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C020243:calcium phosphate