Azithromycin as an alternative to nalidixic acid in the therapy of childhood shigellosis.
In an outbreak of shigellosis in a kibbutz in Northeastern Israel, oral nalidixic acid failed clinically in 35% and microbiologically in 28.4% of 14 children as compared with no clinical and microbiologic failure in 25 children who were treated with oral azithromycin (P < 0.01 and 0.012, respectively). Thus azithromycin could be a suitable alternative to nalidixic acid.
Miron
Dan
D
Pediatric Department A, HaEmek Medical Center, Afula, Israel.
Torem
Moshe
M
Merom
Rivka
R
Colodner
Raul
R
D000284:Administration, Oral; D000293:Adolescent; D017963:Azithromycin / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004196:Disease Outbreaks; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004405:Dysentery, Bacillary / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008297:Male; D009268:Nalidixic Acid / Q000008:administration & dosage*; D011336:Probability; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016896:Treatment Outcome
D009268:Nalidixic Acid; D017963:Azithromycin