title: Thalidomide as a nitric oxide synthase inhibitor and its structural development.
abstract: Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.
authors.affiliation: Institute of Molecular & Cellular Biosciences, The University of Tokyo, Japan. shimazaw@nihs.go.jp
authors.forename: Rumiko
authors.initials: R
authors.lastname: Shimazawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sano
authors.forename: Aya
authors.initials: A
authors.lastname: Tanatani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyachi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D004791:Enzyme Inhibitors; D007700:Kinetics; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013792:Thalidomide; D019001:Nitric Oxide Synthase