title: Samarium-promoted coupling of 1,10-phenanthroline with carbonyl compounds for synthesis of new ligands.
abstract: 1,10-Phenanthroline reacts with aldehydes and ketones in the presence of samarium diiodide to produce 2-(1-hydroxyalkyl)-1,10-phenanthrolines. The hydroxyalkyl substituent can be functionalized in numerous ways or removed to permit further ligand variation. The carbonyl coupling reaction can also be repeated to provide 2,9-disubstituted phenanthrolines. Taken together, these operations provide ready access to a large number of phenanthroline derivatives to serve as ligand libraries for catalyst exploration.
authors.affiliation: Department of Chemistry and Biochemistry and Walther Cancer Research Center, 251 Nieuwland Science Hall, University of Notre Dame, Notre Dame, Indiana 46556, USA.
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: Weitgenant
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Mortison
authors.forename: David J
authors.initials: DJ
authors.lastname: O'Neill
authors.forename: Brendan
authors.initials: B
authors.lastname: Mowery
authors.forename: Anders
authors.initials: A
authors.lastname: Puranen
authors.forename: Paul
authors.initials: P
authors.lastname: Helquist