Mouse models of insulin resistance.
Insulin resistance plays a key role in the pathogenesis of several human diseases, including diabetes, obesity, hypertension, and cardiovascular diseases. The predisposition to insulin resistance results from genetic and environmental factors. The search for gene variants that predispose to insulin resistance has been thwarted by its genetically heterogeneous pathogenesis. However, using techniques of targeted mutagenesis and transgenesis in rodents, investigators have developed mouse models to test critical hypotheses on the pathogenesis of insulin resistance. Moreover, experimental crosses among mutant mice have shed light onto the polygenic nature of the interactions underlying this complex metabolic condition.
Nandi
Anindita
A
Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY, USA.
Kitamura
Yukari
Y
Kahn
C Ronald
CR
Accili
Domenico
D
D000818:Animals; D004195:Disease Models, Animal; D007328:Insulin / Q000502:physiology; D007333:Insulin Resistance / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011972:Receptor, Insulin / Q000502:physiology
D007328:Insulin; D011972:Receptor, Insulin