Lack of association between the interleukin-1 alpha (-889) polymorphism and early-onset Parkinson's disease.
An increasing number of studies have shown that an inflammatory process is part of Parkinson's disease (PD) brain pathology. Interleukin-1 (IL-1) is a multifunctional cytokine and is considered to contribute to several inflammatory diseases. Recently, we detected an associated risk in a subgroup of PD patients with a disease onset < 50 years and a C to T transition in the IL-1alpha promoter (-889). One-hundred-seventy-six German PD patients (42.1 +/- 6.4 years; 42.4% male) and 170 unrelated age-matched control individuals (40.4 +/- 8.7 years; 57.6% male) were investigated for the presence of the IL-1alpha (-889C/T) polymorphism. No significant difference in the allelic distribution of the analyzed IL-1alpha polymorphism has been found between PD and controls. We conclude that the C/T polymorphism in the IL-1alpha promoter region at -889 does not increase the risk to develop PD.
Möller
Jens Carsten
JC
Department of Neurology, Philipps-University, Marburg, Germany.
Depboylu
Candan
C
Kölsch
Heike
H
Lohmüller
Frank
F
Bandmann
Oliver
O
Gocke
Petra
P
Du
Yansheng
Y
Paus
Sebastian
S
Wüllner
Ullrich
U
Gasser
Thomas
T
Oertel
Wolfgang H
WH
Klockgether
Thomas
T
Dodel
Richard C
RC
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005820:Genetic Testing; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods*; D013223:Statistics as Topic
D007375:Interleukin-1