title: Resistance to oxidative stress in a freshwater fish Channa punctatus after exposure to inorganic arsenic.
abstract: The biochemical toxicity of arsenic trioxide (AsIII) in a freshwater edible fish Channa punctatus has been studied on exposures ranging from 7 to 90 d. The arsenic concentration increased exponentially in liver, kidney, gills, and muscles of fish up to 60 d of exposure to arsenic. However, arsenic concentration in these tissues declined at 90 d of exposure. This relationship between period of exposure and concentration of arsenic in selected tissues suggests an adaptive response of fish to arsenic. Furthermore, exposure to arsenic-induced lipid peroxidation in these organs increased initially at 7 d of exposure; however, it decreased up to 60 d of exposure but increased again at 90 d of treatment. Values of reduced glutathione (GSH) reflected the observations of lipid peroxidation. The role of GSH in this adaptive response has been discussed.
authors.affiliation: Department of Environmental Science, Department of Zoology, Ch. Charan Singh University, Meerut-250004, India.
authors.forename: Tanu
authors.initials: T
authors.lastname: Allen
authors.forename: Ritu
authors.initials: R
authors.lastname: Singhal
authors.forename: S V S
authors.initials: SV
authors.lastname: Rana
mesh_terms: D000818:Animals; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism; D029941:Fish Proteins / Q000032:analysis / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D005880:Gills / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010087:Oxides / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D001152:Arsenicals; D029941:Fish Proteins; D010087:Oxides; D005978:Glutathione; D000077237:Arsenic Trioxide