title: Low vs standard calcium dialysate in peritoneal dialysis: differences in treatment, biochemistry and bone histomorphometry. A randomized multicentre study.
abstract: BACKGROUND
  In patients undergoing peritoneal dialysis (PD), low-calcium dialysate (LCD) has been proposed as the first choice for a better control of renal osteodystrophy. Our aim was to compare the effects on bone metabolism of LCD (calcium: 1.25 mmol/l) with that of a standard calcium dialysate (SCD; calcium: 1.75 mmol/l).
  
  
  METHODS
  Forty-four PD patients were randomized to receive LCD or continue on SCD for a period of 12 months. Bone biopsies were taken at baseline and at 12 months. Biochemical data and treatment were evaluated every 3 months.
  
  
  RESULTS
  Twenty-four patients completed the study. In the SCD group (n = 10), nine out of the 10 patients were initially diagnosed with adynamic bone lesion (ABL). After 1 year, six continued having ABL and three patients moved to high-turnover bone lesion (HTBL). The other patient, initially diagnosed with HTBL, changed to ABL. In the LCD group (n = 14), 10 patients were initially diagnosed with ABL. At 1 year, six of them continued having ABL and four patients changed to HTBL. Four patients were initially diagnosed with HTBL and did not change. Comparison between LCD and SCD groups showed an increase in serum parathyroid hormone (PTH) levels starting at month 3 and a higher intake of calcium salts in the former group (P<0.01). Serum calcium, phosphate levels and bone histological outcome did not differ between the two groups.
  
  
  CONCLUSIONS
  LCD use for 1 year was associated with an increase in PTH levels, but did not lead to histological changes different from those observed in SCD group. The LCD solution allowed a higher oral intake of calcium salts with a satisfactory control of the serum Calcium-Phosphorus product.
authors.affiliation: Department of Nephrology, University Hospital La Paz, Madrid, Spain . csanchez.hulp@salud.madrid.org
authors.forename: Carmen
authors.initials: C
authors.lastname: Sánchez
authors.forename: Fernando
authors.initials: F
authors.lastname: López-Barea
authors.forename: Jesús
authors.initials: J
authors.lastname: Sánchez-Cabezudo
authors.forename: Auxiliadora
authors.initials: A
authors.lastname: Bajo
authors.forename: Alberto
authors.initials: A
authors.lastname: Mate
authors.forename: Eugenia
authors.initials: E
authors.lastname: Martínez
authors.forename: Rafael
authors.initials: R
authors.lastname: Selgas
mesh_terms: D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000008:administration & dosage*; D015312:Hemodialysis Solutions; D006801:Humans; D008875:Middle Aged; D010530:Peritoneal Dialysis; D012372:ROC Curve
chemical_list: D015312:Hemodialysis Solutions; D002118:Calcium