title: How good are quantitative complementation tests?
abstract: Several recent studies have used quantitative complementation tests to identify relatively short chromosome regions that contain genes that influence life span and to screen for candidate life-span genes in flies. The methodology and logic of quantitative complementation tests are described. Arguments are presented that suggest that these tests may be misleading because there is a substantial, but unknown, likelihood of false positive results. The arguments are supported by the published results of quantitative complementation tests.
authors.affiliation: Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA. Philip.Service@nau.edu
authors.forename: Philip M
authors.initials: PM
authors.lastname: Service
mesh_terms: D000818:Animals; D005816:Genetic Complementation Test / Q000379:methods* / Q000592:standards*; D040641:Quantitative Trait Loci