[Analysis of microsatellite instability and p53 LOH in advanced colorectal cancers--first report of the No. 3 protocol].
In order to establish the most appropriate protocol of adjuvant chemotherapy for colorectal cancers, several cooperative studies have been undertaken by the Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma (KCSGCCC). In the No. 3 protocol of KCSGCCC, several cancer-associated molecular markers were analyzed to investigate a possible correlation with chemosensitivity and/or patient's prognosis. Here, we report the preliminary results of the analysis of microsatellite instability (MSI) and p53 LOH in 559 cases of Stage II, III colorectal cancer. The MSI was detected in 51 cases (9%) and was shown to have a significant correlation with right-sided localization and histology (poorly differentiated, mucinous). p53 LOH was positive in 225 cases (40%) and was shown to have a significant correlation with left-sided localization and histology (well to moderately differentiated). These results might support the concept of 2 distinct pathways of colorectal carcinogenesis, e.g., RER pathway and LOH pathway.
Tomita
Naohiro
N
Monden
Morito
M
Kikkawa
Nobuteru
N
Imamura
Masayuki
M
Ohtoshi
Masahiro
M
Ohhashi
Shuichi
S
Sakamoto
Tsuguo
T
Tanigawa
Nobuhiko
N
Nakano
Hiroshige
H
Hioki
Koshiro
K
Hirakawa
Kosei
K
Yasutomi
Masayuki
M
Yamamura
Takehira
T
Kameyama
Masao
M
Iwanaga
Takeshi
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016158:Genes, p53; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats; D011379:Prognosis; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery
C017367:carmofur; D005472:Fluorouracil