Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer.
This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 antigen and CEA expression in colon cancer, and CEA expression in rectal cancer that was limited to the metastatic lymph nodes. The immunohistochemical scores were higher in short-term survivors. Our data suggest that the characteristics of metastatic lymph nodes are important as a predictor of the aggressiveness of tumor behavior and that the expression of Ki-67 antigen or CEA there may be a useful indicators of patients' survival in Dukes' C colorectal cancer.
Ishida
Hideyuki
H
Department of Surgery, Sakai Municipal Hospital, 1-1-1 Minamiyasuichou, Sakai 590-0064, Japan. colon777@par.odn.ne.jp
Miwa
Hideaki
H
Tatsuta
Masayuki
M
Masutani
Seizo
S
Imamura
Hiroshi
H
Shimizu
Junzo
J
Ezumi
Koji
K
Kato
Hitoshi
H
Kawasaki
Takatoshi
T
Furukawa
Hiroshi
H
Kawakami
Hitoshi
H
D000368:Aged; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53