[Severe cytomegalic inclusions disease in the fetus of a woman immunized before pregnancy].
After detection of a fetal microcephaly at 24 weeks gestation, we performed an amniocentesis at 29 weeks with chromosomal and polymerase chain reaction (PCR) search for viral contamination. Cytomegalovirus (CMV) infection was confirmed by PCR although the mother had previously been tested as immunized for CMV prior to conception. Abortion was induced; the fetus presented clinical CMV injuries confirmed by positive tissue culture (liver, brain and lungs). Recent publications have reported similar observations with variable viral strains. These findings point out the importance attentive search for ultrasonographic signs suggestive of fetal CMV infection.
Boumahni
B
B
Service de Néonatalogie et Réanimation Néonatale, Groupe Hospitalier Sud Réunion, BP 350, 97448 Saint-Pierre, Ile de la Réunion. boumahni@wanadoo.fr
Randrianaivo
H
H
Laffitte
A
A
Kauffmann
E
E
Barau
G
G
Fourmaintraux
A
A
D000028:Abortion, Induced; D000328:Adult; D000649:Amniocentesis; D003587:Cytomegalovirus / Q000276:immunology* / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D008831:Microcephaly / Q000175:diagnosis / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D011296:Prenatal Diagnosis / Q000379:methods*; D014765:Viral Vaccines / Q000008:administration & dosage*
D014765:Viral Vaccines