title: Should cognitive deficit be a diagnostic criterion for schizophrenia?
abstract: This review examines the question of whether cognitive deficits in schizophrenia are sufficiently reliable, stable and specific to warrant inclusion in the diagnostic criteria for schizophrenia. The literature provides evidence that cognitive deficits are highly prevalent and fairly marked in adult patients with schizophrenia. Similar deficits have been found in children and adolescents with schizophrenia, and in children before they exhibit the signs and symptoms of schizophrenia. These deficits may in fact be central to the pathophysiology underlying the development of overt psychosis in schizophrenia. The deficits appear to be relatively stable across the course of the illness. They are generally more severe in schizophrenia than in affective disorders and may have a relatively specific pattern in schizophrenia. It is concluded that the evidence that cognitive deficits are a core feature of schizophrenia is sufficiently compelling to warrant inclusion of these deficits in the diagnostic criteria for schizophrenia, at least as a nonessential criterion.
authors.affiliation: Department of Psychiatry, University of Toronto, and Division of Youth Psychiatry, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ont. ralph.lewis@utoronto.ca
authors.forename: Ralph
authors.initials: R
authors.lastname: Lewis
mesh_terms: D000293:Adolescent; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications*