title: Antioxidant properties of novel benzimidazole retinoids.
abstract: Our approach was to examine the antioxidant activity of novel retinoid derivatives containing the benzimidazole moiety. Their in vitro effects on rat liver microasomal, NADPH-dependent lipid peroxidation levels and superoxide anion formation were determined. Lipid peroxidation in rat liver microsomes was reduced by some of the compounds in a dose-dependent manner.
authors.affiliation: Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Tandogan, Ankara, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Ates-Alagoz
authors.forename: Benay
authors.initials: B
authors.lastname: Can-Eke
authors.forename: Tulay
authors.initials: T
authors.lastname: Coban
authors.forename: Mumtaz
authors.initials: M
authors.lastname: Iscan
authors.forename: Erdem
authors.initials: E
authors.lastname: Buyukbingol
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012176:Retinoids / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D001562:Benzimidazoles; D012176:Retinoids; D013481:Superoxides