title: Lack of association between the interleukin-1 alpha (-889) polymorphism and early-onset Parkinson's disease.
abstract: An increasing number of studies have shown that an inflammatory process is part of Parkinson's disease (PD) brain pathology. Interleukin-1 (IL-1) is a multifunctional cytokine and is considered to contribute to several inflammatory diseases. Recently, we detected an associated risk in a subgroup of PD patients with a disease onset < 50 years and a C to T transition in the IL-1alpha promoter (-889). One-hundred-seventy-six German PD patients (42.1 +/- 6.4 years; 42.4% male) and 170 unrelated age-matched control individuals (40.4 +/- 8.7 years; 57.6% male) were investigated for the presence of the IL-1alpha (-889C/T) polymorphism. No significant difference in the allelic distribution of the analyzed IL-1alpha polymorphism has been found between PD and controls. We conclude that the C/T polymorphism in the IL-1alpha promoter region at -889 does not increase the risk to develop PD.
authors.affiliation: Department of Neurology, Philipps-University, Marburg, Germany.
authors.forename: Jens Carsten
authors.initials: JC
authors.lastname: Möller
authors.forename: Candan
authors.initials: C
authors.lastname: Depboylu
authors.forename: Heike
authors.initials: H
authors.lastname: Kölsch
authors.forename: Frank
authors.initials: F
authors.lastname: Lohmüller
authors.forename: Oliver
authors.initials: O
authors.lastname: Bandmann
authors.forename: Petra
authors.initials: P
authors.lastname: Gocke
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Du
authors.forename: Sebastian
authors.initials: S
authors.lastname: Paus
authors.forename: Ullrich
authors.initials: U
authors.lastname: Wüllner
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
authors.forename: Wolfgang H
authors.initials: WH
authors.lastname: Oertel
authors.forename: Thomas
authors.initials: T
authors.lastname: Klockgether
authors.forename: Richard C
authors.initials: RC
authors.lastname: Dodel
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005820:Genetic Testing; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment / Q000379:methods*; D013223:Statistics as Topic
chemical_list: D007375:Interleukin-1