title: Spontaneous closure of ventricular septal defects followed up from <3 months of age.
abstract: BACKGROUND
  This study evaluates the incidence and timing of spontaneous closure (SC) of ventricular septal defect (VSD) using Doppler color flow mapping.
  
  
  METHODS
  A total of 225 infants (mean age 30 days) were diagnosed with uncomplicated VSD: 31 (14%) subpulmonary VSD, 159 (70%) perimembranous, and 35 (16%) muscular. The patients were divided into two groups according to the presence or absence of congestive heart failure (CHF). SC was confirmed with color Doppler.
  
  
  RESULTS
  Surgical closure was performed in 59 patients (26%). SC occurred in 107 patients (48%); three (10%) of 31 with subpulmonary VSD, 75 (47%) of 159 with perimembranous VSD, and 29 (83%) of 35 with a muscular VSD. Average age at SC was 19 months. In three SC patients with a subpulmonary VSD, there was no aortic valve prolapse and no aortic regurgitation. SC occurred in 96% of SC patients with a perimembranous VSD by the age of 6 years, and in 93% of those with a muscular VSD by the age of 3 years. In patients without CHF, the rate of SC was 72%; 23% in subpulmonary VSD, 74% in perimembranous, and 85% in muscular. SC occurred in only 23% of patients with a perimembranous VSD with CHF. Mean age at the final examination was 6.9 years in 59 patients with a VSD remaining open, and 63% of patients with a perimembranous VSD remaining open had an aneurysm of the ventricular membranous septum.
  
  
  CONCLUSIONS
  The SC rate of VSD by mean age of 6.9 years was 48%, but it was 72% in patients without CHF. In patients with CHF, SC was seen only in patients with a perimembranous VSD. The rate of SC was 10% in subpulmonary VSD. The authors contend that SC probably occurred by growth of muscular septum surrounding VSD. Muscular VSD spontaneously closed earlier than perimembranous VSD.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, Kinki University School of Medicine, Osakasayama, Japan. miyake@kpcd.med.kindai.ac.jp
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Miyake
authors.forename: Tohru
authors.initials: T
authors.lastname: Shinohara
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tasato
authors.forename: Keiko
authors.initials: K
authors.lastname: Toyohara
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tanihira
mesh_terms: D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012075:Remission, Spontaneous; D013997:Time Factors