Polymyositis and hepatitis concurrent with breast cancer.
OBJECTIVE
To present a rare case of breast cancer associated with both inflammatory muscle disease and liver disease as a paraneoplastic syndrome.


METHODS
A woman with breast cancer presented with elevated liver enzymes and progressive proximal muscle weakness. Liver biopsy was consistent with hepatitis and muscle biopsy revealed myositis. The start of corticosteroid therapy was followed by relief of the myopathic symptoms and regression of hepatitis histopathologically.


CONCLUSIONS
A case of polymyositis and hepatitis associated with breast cancer and their flare-up with recurrence of malignancy is presented. In this case, the temporal relation with malignancy following its concurrent remission and relapse suggests a paraneoplastic mechanism.
Yamac
Deniz
D
Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey. dyamac@gazi.edu.tr
Gunel
Nazan
N
Goker
Berna
B
Coskun
Ugur
U
Erdem
Ozlem
O
Akyol
Gulen
G
Ozenirler
Seren
S
D001344:Autopsy; D001943:Breast Neoplasms / Q000150:complications*; D018270:Carcinoma, Ductal, Breast / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006526:Hepatitis C / Q000175:diagnosis* / Q000201:enzymology; D018937:Hepatitis C Antibodies / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness; D018482:Muscle, Skeletal / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D017285:Polymyositis / Q000473:pathology*; D012367:RNA, Viral / Q000302:isolation & purification; D013997:Time Factors
D018937:Hepatitis C Antibodies; D012367:RNA, Viral