Evaluation of rapid assay for detection of Streptococcus pneumoniae urinary antigen among infants and young children with possible invasive pneumococcal disease.
The usefulness of the rapid assay for detection of Streptococcus pneumoniae urinary antigen was evaluated in 155 children ages 1 to 60 months with suspected invasive pneumococcal disease and 200 healthy controls. Although the assay was highly sensitive in the children with invasive pneumococcal disease, it should be interpreted with caution in young patients because a positive urine test result may simply be the result of nasopharyngeal colonization.
Esposito
Susanna
S
Institute of Pediatrics, University of Milan, Via Commenda 9, 20122 Milan, Italy. Nicola.Principi@unimi.it
Bosis
Samantha
S
Colombo
Rosaria
R
Carlucci
Patrizia
P
Faelli
Nadia
N
Fossali
Emilio
E
Principi
Nicola
N
D000942:Antigens, Bacterial / Q000032:analysis* / Q000652:urine; D016470:Bacteremia / Q000175:diagnosis* / Q000453:epidemiology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D011008:Pneumococcal Infections / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013296:Streptococcus pneumoniae / Q000302:isolation & purification*; D016482:Urinalysis
D000942:Antigens, Bacterial