Drug-induced pulmonary edema and acute respiratory distress syndrome.
Noncardiogenic pulmonary edema, and, to a lesser extent, acute respiratory distress syndrome (ARDS), are common clinical manifestations of drug-induced lung diseases. Clinical features and radiographic appearances are generally indistinguishable from other causes of pulmonary edema and ARDS. Typical manifestations include dyspnea, chest discomfort, tachypnea, and hypoxemia. Chest radiographs commonly reveal interstitial and alveolar filling infiltrates. Unlike pulmonary edema that is due to congestive heart failure, cardiomegaly and pulmonary vascular redistribution are generally absent in cases that are drug-related. Rare cases of drug-induced myocarditis with heart failure and pulmonary edema have been described. Results from laboratory evaluation and respiratory function tests are nonspecific.
Lee-Chiong
Teofilo
T
Section of Pulmonary Medicine, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA. lee-chiongt@njc.org
Matthay
Richard A
RA
D000970:Antineoplastic Agents / Q000009:adverse effects; D002740:Chlorothiazide / Q000009:adverse effects; D003287:Contrast Media; D004232:Diuretics; D004984:Ethchlorvynol / Q000009:adverse effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D007049:Iatrogenic Disease; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008168:Lung / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D015149:Tocolytic Agents / Q000009:adverse effects; D014212:Tretinoin / Q000009:adverse effects
D000970:Antineoplastic Agents; D003287:Contrast Media; D004232:Diuretics; D006993:Hypnotics and Sedatives; D007166:Immunosuppressive Agents; D049993:Sodium Chloride Symporter Inhibitors; D015149:Tocolytic Agents; D014212:Tretinoin; D004984:Ethchlorvynol; D002740:Chlorothiazide