Complications of androgen deprivation therapy in men with prostate cancer.
Androgen deprivation therapy (ADT) is indicated for the treatment of metastatic prostate cancer and locally advanced disease. In addition to sexual side effects, long-term ADT results in several other changes, including hot flashes; gynecomastia; changes in body composition, metabolism, and the cardiovascular system; osteoporosis; anemia; psychiatric and cognitive problems; and fatigue and diminished quality of life. This review discusses these complications of ADT and treatments aimed at reducing them. It is important for clinicians to anticipate these effects and to initiate measures to prevent or minimize them in order to maintain quality of life in prostate cancer survivors.
Chen
Allen C
AC
Department of Medicine, College of Physicians and Surgeons, Columbia University, 177 Fort Washington Avenue, MHB 6-435, New York, NY 10032, USA. acc23@columbia.edu
Petrylak
Daniel P
DP
D000726:Androgen Antagonists / Q000009:adverse effects*; D000740:Anemia / Q000209:etiology; D001823:Body Composition / Q000187:drug effects; D003072:Cognition Disorders / Q000209:etiology; D005221:Fatigue / Q000209:etiology; D006177:Gynecomastia / Q000209:etiology; D019584:Hot Flashes / Q000209:etiology; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology; D009919:Orchiectomy / Q000009:adverse effects*; D010024:Osteoporosis / Q000209:etiology; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D011788:Quality of Life; D020018:Sexual Dysfunctions, Psychological / Q000209:etiology
D000726:Androgen Antagonists