Comparison of patients with Behçet's disease in the 1980s and 1990s.
OBJECTIVE
To compare clinical findings in patients with Behçet's disease (BD) seen in 2 different decades (1980s and 1990s) to determine if there has been a shift toward the appearance of less severe disease.


METHODS
Retrospective, comparative case series.


METHODS
Two hundred forty patients with uveitis caused by BD who had their first visit and at least a 4-month follow-up at the uveitis clinic of University of Tokyo Hospital between January 1980 and December 1999 were enrolled.


METHODS
Patients were divided into 2 groups according to the date of the first visit. The clinical profiles were then compared between the 1980s group (133 patients, observed for 33.5+/-26.4 months) and the 1990s group (107 patients, observed for 46.9+/-32.6 months).


METHODS
Number of ocular attacks per year, visual outcomes, and the percentage of patients who had cyclosporine or cyclophosphamide therapy.


RESULTS
Age of onset, type of inflammation, incidence of secondary glaucoma, and surgical history of glaucoma and cataract did not differ between the 1980s and the 1990s. Conversely, in patients in the 1990s, the number of ocular attacks per year and the percentage of patients with cyclosporine or cyclophosphamide therapy decreased significantly. Furthermore, the percentage of eyes with good visual acuity (VA) (?20/30) increased, and the percentage of eyes with poor VA (<20/200) decreased significantly at both the first and the last examinations. There was a trend for less bilateral disease and fewer genital ulcers in the 1990s as well.


CONCLUSIONS
Through a study of Japanese patients, we confirmed that the clinical outcomes of BD, especially judging by the number of ocular attacks per year and VA, indeed improved during the 1990s.
Yoshida
Atsushi
A
Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. a-yosida@sage.ocn.ne.jp
Kawashima
Hidetoshi
H
Motoyama
Yuta
Y
Shibui
Hirobumi
H
Kaburaki
Toshikatsu
T
Shimizu
Kazuyuki
K
Ando
Kazuhiko
K
Hijikata
Kiyono
K
Izawa
Yasuho
Y
Hayashi
Kiyofumi
K
Numaga
Jiro
J
Fujino
Yujiro
Y
Masuda
Kanjiro
K
Araie
Makoto
M
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001528:Behcet Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D003078:Colchicine / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014792:Visual Acuity
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003078:Colchicine