An interactive triple-helical collagen builder.
To facilitate the building of triple-helical polypeptide structures, we provide an interactive, platform-independent Tcl/Tk script. User specified amino acid sequences are parsed to obtain localized melting temperature estimates corresponding to helical propensity. These propensities may be graphically examined prior to their automated use in combination with two separate statistical parameter sets to build the complete polypeptide backbone and, if desired, predict side-chain terminal atom locations.


BACKGROUND
The Tcl/Tk Triple Helical collagen Building Script (THe BuScr) and full documentation is freely available under the terms of the GNU General Public License at www.pence.ca/~jrainey/ or www.chem.utoronto.ca/staff/MCG/.
Rainey
Jan K
JK
Protein Engineering Network of Centres of Excellence, University of Alberta, Edmonton, AB, T6G 2S2 Canada. jrainey@biochem.ualberta.ca
Goh
M Cynthia
MC
D000465:Algorithms; D003094:Collagen / Q000032:analysis* / Q000737:chemistry*; D003198:Computer Simulation; D008958:Models, Molecular; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D014584:User-Computer Interface
D003094:Collagen