title: Prenatal diagnosis of an extra der(4) resulting from a complex maternal chromosome translocation.
abstract: We report the prenatal diagnosis of an extra der(4) resulting from 4:2 malsegregation of a maternal balanced complex translocation involving chromosomes 4, 10, and 11. The woman was referred for amniocentesis because of recurrent miscarriages. Fluorescence in situ hybridization was performed in order to characterize the complex chromosome rearrangement. Following genetic counselling, the couple decided to terminate the pregnancy.
authors.affiliation: Centre of Medical Genetic and Prenatal Diagnosis, Az.Osp, G.Salesi, Ancona, Italy. salgenan@infinito.it
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: Migliori
authors.forename: Antonella
authors.initials: A
authors.lastname: Pettinari
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Ciaschini
authors.forename: Paola
authors.initials: P
authors.lastname: Piermattei
authors.forename: Francesco
authors.initials: F
authors.lastname: Pigliapoco
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Discepoli
mesh_terms: D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic