title: Surgery for esophageal carcinoma and the role of neoadjuvant therapy.
abstract: Esophagectomy is a major surgical procedure. Due to the related morbidity and mortality, this operation should be carried out in high-volume referral centers by expert surgeons. Only patients in whom a complete resection is predictable at preoperative staging can consistently benefit from the operation. Chemoradiation therapy should be the first-line approach in patients with locally advanced tumors. A pathological complete response to neoadjuvant therapy is associated with a significantly improved long-term survival.
authors.affiliation: Department of Medical and Surgical Sciences, Division of General Surgery, Istituto Policlinico San Donato, University of Milan. luigi.bonavina@unimi.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Bonavina
authors.forename: Davide
authors.initials: D
authors.lastname: Bona
authors.forename: Alberto
authors.initials: A
authors.lastname: Luporini
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Navoni
authors.forename: Roberto
authors.initials: R
authors.lastname: Zucali
mesh_terms: D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision; D020360:Neoadjuvant Therapy