title: Chemokine receptors and early activation markers in acute anterior uveitis.
abstract: OBJECTIVE
  To study the peripheral expression of chemokine receptors and early activation markers in acute anterior uveitis (AU).
  
  
  METHODS
  The expression of chemokine receptors CCR1, CCR2, CCR3, CCR5 and CXCR3, and activation markers CD25 (IL2R-alpha-chain), CD122 (IL2R-beta-chain) and CD69 were studied on peripheral blood mononuclear cells using flow cytometry in 10 patients with acute anterior uveitis and in 10 healthy controls.
  
  
  RESULTS
  We found a highly significant up-regulation of CCR5 (p < 0.001) on CD4+ T-cells in the blood of patients with AU compared to in healthy controls. CD69 was significantly higher on both CD4+ and CD8+ T-cells (p < 0.05 and p < 0.001, respectively). We also found a significantly higher expression of CD25 expressing CD4+ T-cells in patients with anterior uveitis (p < 0.05). This expression was directly correlated to the severity of disease (rho = 0.720, p < 0.05).
  
  
  CONCLUSIONS
  Our data show that patients with acute anterior uveitis have a specific systemic immune activation.
authors.affiliation: Department of Ophthalmology, Herlev Hospital, University of Copenhagen, Herlev, Denmark. torbenls@dadlnet.dk
authors.forename: Torben L Sørensen
authors.initials: TL
authors.lastname: Klitgaard
authors.forename: Carsten
authors.initials: C
authors.lastname: Øgard
authors.forename: Erik
authors.initials: E
authors.lastname: Krogh
mesh_terms: D000208:Acute Disease; D000328:Adult; D015703:Antigens, CD / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D037181:Lectins, C-Type; D008297:Male; D008875:Middle Aged; D019707:Receptors, Chemokine / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D015854:Up-Regulation; D014606:Uveitis, Anterior / Q000378:metabolism*; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D037181:Lectins, C-Type; D019707:Receptors, Chemokine; D015375:Receptors, Interleukin-2; D000099192:CD69 Antigens