Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome.
BACKGROUND
It is controversial which component of blood pressure (BP) during acute period of stroke best predicts outcome. We hypothesized that elevated pulse pressure (PP), the difference between systolic BP (SBP) and diastolic BP (DBP), is independently associated with poor stroke outcome at 3 months.


METHODS
We analyzed both treatment groups from the Glycine Antagonist (Gavestinel) in Neuroprotection (GAIN) International trial (1455 ischemic stroke cases of mostly moderate severity). Cox proportional hazards and logistic regression modeling corrected for demography, medical history, heart rate, stroke severity, and clinical subtype.


RESULTS
Elevated weighted average PP during the first 60 hours was associated with poor outcome by mortality, Barthel index, National Institutes of Health Stroke Score (NIHSS) and Rankin scores. Elevated baseline PP was associated with Barthel index and Rankin score.


CONCLUSIONS
Elevated PP is associated with poor stroke outcome at 3 months.
Aslanyan
Stella
S
Division of Cardiovascular and Medical Sciences, University of Glasgow, Scotland. stella_s_aslanyan@hotmail.com
Weir
Christopher J
CJ
Lees
Kennedy R
KR
D000208:Acute Disease; D001794:Blood Pressure; D002545:Brain Ischemia / Q000175:diagnosis*; D003971:Diastole; D006801:Humans; D011379:Prognosis; D020521:Stroke / Q000175:diagnosis*; D013599:Systole