title: Hypoxia-inducible factor 1alpha-deficient chimeric mice as a model to study abnormal B lymphocyte development and autoimmunity.
authors.affiliation: Division on Immunology, Institute for Medical Science, Dokkyo University School of Medicine, Tochigi, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Kojima
authors.forename: Brendan T
authors.initials: BT
authors.lastname: Jones
authors.forename: Jianzhu
authors.initials: J
authors.lastname: Chen
authors.forename: Marilia
authors.initials: M
authors.lastname: Cascalho
authors.forename: Michail V
authors.initials: MV
authors.lastname: Sitkovsky
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000502:physiology*; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology*; D002678:Chimera; D004247:DNA / Q000276:immunology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018390:Gene Targeting / Q000379:methods*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D051379:Mice; D018345:Mice, Knockout; D011507:Proteinuria / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics*
chemical_list: D001323:Autoantibodies; D004268:DNA-Binding Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C499308:Rag2 protein, mouse; D014157:Transcription Factors; C064655:V(D)J recombination activating protein 2; D004247:DNA