title: First report of Cryptococcus albidus--induced disseminated cryptococcosis in a renal transplant recipient.
abstract: Cryptococcus albidus, a non-neoformans species of the genus Cryptococcus, is generally regarded as a rare cause of disease. There have been only 14 previously reported cases in which this organism has been isolated as a pathogen, none of which occurred in a renal transplant recipient. A 23-year-old renal transplant recipient taking medication consisting of cyclosporine and prednisolone was admitted with a 10-day history of dry cough, fever and progressive dyspnea. The next day, his respiratory status deteriorated dramatically, and he developed acute respiratory distress syndrome (ARDS) and fulminant septic shock. On the eighth hospital day, tender macules on both his shins coalesced to form erythematous patches. Cryptococcus albidus was isolated by skin biopsy and tissue culture. We report here the first case of disseminated cryptococcosis caused by C. albidus in a renal transplant recipient who had been successfully treated with fluconazole monotherapy.
authors.affiliation: Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Yeon Ah
authors.initials: YA
authors.lastname: Lee
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Tae Won
authors.initials: TW
authors.lastname: Lee
authors.forename: Myung Jae
authors.initials: MJ
authors.lastname: Kim
authors.forename: Mu Hyoung
authors.initials: MH
authors.lastname: Lee
authors.forename: Ju Hie
authors.initials: JH
authors.lastname: Lee
authors.forename: Chun Gyoo
authors.initials: CG
authors.lastname: Ihm
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D016572:Cyclosporine / Q000009:adverse effects; D003937:Diagnosis, Differential; D015725:Fluconazole / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D015725:Fluconazole