The genetic variant of lactase persistence C (-13910) T as a risk factor for type I and II diabetes in the Finnish population.
OBJECTIVE
Lactase persistence (LP), the ability to maintain a high lactase activity throughout life, has been suggested to be a possible risk factor for diabetes. Recently, a single nucleotide polymorphism C (-13910) T, residing 14 kb from the 5' end of the lactase (LCT) gene was shown to be associated with LP. Here we have studied the relationship between C (13910) T polymorphism and diabetes in the Finnish population.


METHODS
In all, 1455 patients with type I and 615 with type II diabetes and 446 nondiabetic controls in the Finnish population were genotyped for the C (-13910) T polymorphism by PCR minisequencing.


RESULTS
No differences were detected in the LP genotype frequencies (CT&TT) between diabetic and nondiabetic subjects.


CONCLUSIONS
We conclude that the C (-13910) T polymorphism associated with lifelong LP is not a risk factor for type I or type II diabetes in the Finnish population.
Enattah
N S
NS
Department of Medical Genetics, University of Helsinki, Helsinki, Finland.
Forsblom
C
C
Rasinperä
H
H
Tuomi
T
T
Groop
P-H
PH
Järvelä
I
I
D000328:Adult; D000368:Aged; D003920:Diabetes Mellitus / Q000201:enzymology* / Q000235:genetics; D005260:Female; D005387:Finland; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D043322:Lactase / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors
D043322:Lactase