title: Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22.
abstract: Previously, we have reported linkage of markers from chromosome 1q22 to schizophrenia, a finding supported by several independent studies. We have now examined the region of strongest linkage for evidence of linkage disequilibrium (LD) in a sample of 24 Canadian familial-schizophrenia pedigrees. Analysis of 14 microsatellites and 15 single-nucleotide polymorphisms (SNPs) from the 5.4-Mb region between D1S1653 and D1S1677 produced significant evidence (nominal P<.05) of LD between schizophrenia and 2 microsatellites and 6 SNPs. All of the markers exhibiting significant LD to schizophrenia fall within the genomic extent of the gene for carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (CAPON), making it a prime positional candidate for the schizophrenia-susceptibility locus on 1q22, although initial mutation analysis of this gene has not identified any schizophrenia-associated changes within exons. Consistent with several recently identified candidate genes for schizophrenia, CAPON is involved in signal transduction in the NMDA receptor system, highlighting the potential importance of this pathway in the etiology of schizophrenia.
authors.affiliation: Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA. brzustowicz@biology.rutgers.edu
authors.forename: Linda M
authors.initials: LM
authors.lastname: Brzustowicz
authors.forename: Jaime
authors.initials: J
authors.lastname: Simone
authors.forename: Paria
authors.initials: P
authors.lastname: Mohseni
authors.forename: Jared E
authors.initials: JE
authors.lastname: Hayter
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Hodgkinson
authors.forename: Eva W C
authors.initials: EW
authors.lastname: Chow
authors.forename: Anne S
authors.initials: AS
authors.lastname: Bassett
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000483:Alleles; D002170:Canada; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D002878:Chromosomes, Human, Pair 1; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005190:Family; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C488081:NOS1AP protein, human; C110667:Nos1ap protein, mouse; D004247:DNA