title: Eye models for the prediction of contrast vision in patients with new intraocular lens designs.
abstract: Theoretical calculations of the polychromatic modulation transfer function (MTF) and wave-front aberration were performed with physiological eye models. These eye models have an amount of spherical aberration that is representative of a normal population of pseudophakic eyes implanted with two different types of intraocular lens (IOL) made from high-refractive-index silicone. These theoretical calculations were compared with the measured contrast sensitivity function (CSF) under mesopic lighting conditions and with wave-front aberration (obtained with a Hartmann-Shack wave-front sensor) collected from 37 patients bilaterally implanted with the same types of lens. The relationships between the ocular wave-front aberration and the MTF predicted by the eye models and the CSF and the ocular wave-front aberration measured in eyes implanted with IOLs were investigated. The predicted improvements in MTF and wave-front aberration correlated well with the improvements measured in practice. Physiological eye models are therefore useful tools for IOL design.
authors.affiliation: Department of Applied Research, Pfizer Groningen BV, Van Swietenlaan 5, 9728 NX Groningen, The Netherlands. patricia.piers@pfizer.com
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Piers
authors.forename: N E Sverker
authors.initials: NE
authors.lastname: Norrby
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mester
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015350:Contrast Sensitivity; D004867:Equipment Design; D005123:Eye / Q000503:physiopathology*; D006801:Humans; D007910:Lenses, Intraocular; D008875:Middle Aged; D008954:Models, Biological; D008962:Models, Theoretical; D011379:Prognosis