title: Metabolic, anthropometric, and nutritional factors as predictors of circulating insulin-like growth factor binding protein-1 levels in middle-aged and elderly men.
abstract: Circulating IGF binding protein (IGFBP)-1 levels have been associated with insulin sensitivity, the metabolic syndrome, several cardiovascular risk factors, and possibly with cancer. We examined long-term nutrient intake and metabolic and anthropometric factors in relation to IGFBP-1 levels in 226 men, 42-76 yr old, who completed 14 24-h diet recall interviews. Spearman rank correlation coefficients were calculated. Serum IGFBP-1 levels were significantly inversely correlated with insulin, homeostasis model assessment-insulin resistance, and IGF-I and positively correlated with age. Furthermore, IGFBP-1 was inversely correlated with anthropometric measures reflecting obesity, somewhat stronger in middle-aged (<65 yr) than in older men. Serum IGFBP-1 increased with higher energy and carbohydrate intake but only in the younger age group. The difference in mean IGFBP-1 levels comparing men in the top quartile of carbohydrate intake with those in the bottom quartile was 45% in men of age 42-54 yr (P = 0.01). Insulin, body mass index, and carbohydrate intake together explained 39% of the variability in IGFBP-1 levels in men 42-54 yr of age, 27% in men 55-64 yr, and 6% in men 65 or more years old. Our data suggest that metabolic, anthropometric, and nutritional factors are important determinants of IGFBP-1 levels in healthy men.
authors.affiliation: Department of Medicine, Karolinska Institutet, SE-17177 Stockholm. katarina.wolk@ks.se
authors.forename: Katarina
authors.initials: K
authors.lastname: Wolk
authors.forename: Susanna C
authors.initials: SC
authors.lastname: Larsson
authors.forename: Bengt
authors.initials: B
authors.lastname: Vessby
authors.forename: Alicja
authors.initials: A
authors.lastname: Wolk
authors.forename: Kerstin
authors.initials: K
authors.lastname: Brismar
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood / Q000378:metabolism*; D000886:Anthropometry; D015992:Body Mass Index; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000097:blood; D012016:Reference Values
chemical_list: D004040:Dietary Carbohydrates; D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I