[Gene therapy for the treatment of patients with brain gliomas].
The prognosis of patients with brain gliomas remains poor despite the use of advanced surgical techniques, radio- and chemotherapy. In this respect, gene engineering techniques altering the glioma genome in order to regulate the function of key genes involved in cancerogenesis seem to be promising. The premise for applying a gene therapy in patients with brain gliomas is described, together with basic strategies and results of hitherto performed experimental and clinical studies, mostly with the use of virus vectors. The rapid progress in molecular techniques may enable to overcome methodological problems related to the introduction of the therapeutic gene into the target cell, and thus to improve so far unsatisfactory results of glioma gene therapy. The important role of a neurosurgeon in the process of precise gene vector application to the tumour area should not be underestimated.
Słowiński
Jerzy
J
Katedra i Oddział Kliniczny Neurochirurgii i Neurotraumatologii, Slaska Akademia Medyczna, al. Leginów 10, 41-902 Bytom. slowian@mp.pl
Mrówka
Ryszard
R
D051017:Apoptosis Regulatory Proteins; D001932:Brain Neoplasms / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D004815:Epidermal Growth Factor / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D005910:Glioma / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008967:Molecular Biology / Q000379:methods*; D011493:Protein Kinase C / Q000235:genetics; D011506:Proteins / Q000235:genetics; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; C109664:caspase-activated DNase inhibitor; C070699:FGFBP1 protein, human; D004815:Epidermal Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor; D011493:Protein Kinase C