Mammographic change in hysterectomized women on 0.625 mg/day of conjugated equine estrogen.
OBJECTIVE
To compare the mammographic change before and after conjugated equine estrogen (CEE) 0.625 mg/day in hysterectomized women.


METHODS
A retrospective descriptive study.


METHODS
Menopause clinic, Maharaj Nakorn Chiang Mai Hospital.


METHODS
Dedicated mammograms and demographic data of 66 women who had been hysterectomized were reviewed. Post surgical menopausal women were recruited for the study. CEE 0.625 mg/day was given just after the operation. The baseline mammography was done before the initiation of HRT and they were compared with the follow-up mammography performed 12-18 months after therapy. The degree of increase in mammographic density was classified as follows: minimal changes (10-25% increased density), moderated change (26-50% increased density), and marked change (> 50% increased density).


RESULTS
The mean age +/- SD was 47 +/- 4.3 years old. The mean duration +/- SD of hormone used was 13.5 +/- 2.4 months. The most common indication for operation was myoma uteri (43.9%). On the baseline mammogram, 5 cases had cystic change and one case had a small circumscribed solid mass suspected to be fibroadenoma. On the follow-up mammograms, there were 2 cases (3.0%) detected to have significantly increased breast density. One was moderately increased and the other was markedly increased, but cystic changes and one fibroadenoma were not changed.


CONCLUSIONS
CEE has little effect on increased mammographic density.
Panpanit
Ataporn
A
Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand.
Muttarak
Malai
M
Pongsatha
Saipin
S
Chaovisitsaree
Somsak
S
Piyamongkol
Wirawit
W
Truengthawatchai
Sompong
S
Morakot
Nuntana
N
Sribanditmongkol
Narisa
N
Noi-um
Supranee
S
Churith
Kunnika
K
Chuntaranikul
Malinee
M
D000328:Adult; D001940:Breast / Q000473:pathology*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D012494:Sampling Studies; D012680:Sensitivity and Specificity
D004966:Estrogens, Conjugated (USP)