Interleukin-17 and the interleukin-17 family member network.
Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45+ RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.
Huang
Shu-Hai
SH
Guangxi Institute of Occupational Health, Nanning, China.
Frydas
Stavros
S
Kempuraj
Duraisamy
D
Barbacane
Renato C
RC
Grilli
Alfredo
A
Boucher
William
W
Letourneau
Richard
R
Madhappan
Bhuvaneshwari
B
Papadopoulou
Nikoletta
N
Verna
Nicola
N
De Lutiis
Maria Anna
MA
Iezzi
Teresa
T
Riccioni
Graziano
G
Theoharides
Theoharis C
TC
Conti
Pio
P
D001847:Bone Diseases / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D020381:Interleukin-17 / Q000276:immunology / Q000502:physiology*; D007410:Intestinal Diseases / Q000276:immunology / Q000378:metabolism; D007592:Joint Diseases / Q000276:immunology / Q000378:metabolism; D007674:Kidney Diseases / Q000276:immunology / Q000378:metabolism; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D018836:Inflammation Mediators; D020381:Interleukin-17