Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants.
Isogenic strains containing insertional disruptions of 10 Haemophilus influenzae Rd genes were investigated for their effects on the susceptibility of the organism to various classes of antimicrobial compounds. MIC results show that HI1462, which encodes an Escherichia coli TolC homolog, is the third component of the H. influenzae AcrAB pump.
Trepod
Catherine M
CM
Antibacterials, Pfizer, Groton, Connecticut 06340, USA. catherine.m.trepod@pfizer.com
Mott
John E
JE
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins / Q000235:genetics; D006193:Haemophilus influenzae / Q000235:genetics*; D008074:Lipoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D016254:Mutagenesis, Insertional; D009154:Mutation / Q000235:genetics* / Q000502:physiology*; D009841:Oligonucleotides / Q000235:genetics
D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D004251:DNA Transposable Elements; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009841:Oligonucleotides; C083497:AcrA protein, E coli; C083496:AcrB protein, E coli; C073126:tolC protein, E coli