[lnhibition of arsenic trioxide on human tongue cancer cell line Tca8113 cells in Scid mice in vivo]
OBJECTIVE:To explore the antitumor effect of As(2)O(3) in Scid mice.METHODS:Human tongue cancer cell line Tca8113 cells were transp lanted to the subcutaneous tissues of Scid mice to produce tumors.The tumor inhibition rate (TIR) of As(2)O(3) was observed in Scid mice. RESULTS:The TIR of As(2)O(3) was 49.16%,Cytomorphologic study showed that arsenic trioxide induced apoptosis of Tca8113 cells.CONCLUSION: As(2)O(3) may have a good treating effect on oral squamous cell carcinoma.
Wang
Y P
YP
Department of Oral and Maxillofacial Surgery,School of Stomatology,Shanghai Second Medical University.Shanghai 200011,China.
Zhu
H G
HG
Zhang
Z Y
ZY