title: Cutaneous reflexes from the foot during gait in hereditary spastic paraparesis.
abstract: OBJECTIVE
  It is known that P2 cutaneous reflexes from the foot show phase-dependent modulation during gait. The role of the motor cortex and the cortico-spinal tract in these reflexes and their modulation is unknown. Patients with hereditary spastic paraparesis (HSP) have a lesion in the cortico-spinal tract and may show deficits in P2 reflexes and/or their modulation.
  
  
  METHODS
  Reflex responses of tibialis anterior and biceps femoris after sural nerve stimulation in 10 HSP-patients were compared with those in 10 healthy subjects. The reflexes were studied at two different moments in the step cycle during walking on a treadmill.
  
  
  RESULTS
  Both patients and controls showed a phase-dependent modulation of P2 responses. For the individual muscles, no significant difference in reflex activity was observed between HSP-patients and the controls. However, when all muscles were taken together, the reflex activity for the controls was significantly higher than for the patients.
  
  
  CONCLUSIONS
  The results of this study suggest that the cortico-spinal tract is involved in the regulation of the amplitude of the P2 responses and their phase-dependent modulation.
authors.affiliation: Department of Biophysics, University Medical Center, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands. jaak@mbfys.kun.nl
authors.forename: J
authors.initials: J
authors.lastname: Duysens
authors.forename: B C M
authors.initials: BC
authors.lastname: Baken
authors.forename: L
authors.initials: L
authors.lastname: Burgers
authors.forename: F M
authors.initials: FM
authors.lastname: Plat
authors.forename: A R
authors.initials: AR
authors.lastname: den Otter
authors.forename: H P H
authors.initials: HP
authors.lastname: Kremer
mesh_terms: D000328:Adult; D019540:Area Under Curve; D016022:Case-Control Studies; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D005528:Foot / Q000503:physiopathology*; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000503:physiopathology; D020336:Paraparesis, Spastic / Q000235:genetics / Q000503:physiopathology*; D012018:Reflex; D012867:Skin / Q000503:physiopathology*; D013497:Sural Nerve / Q000503:physiopathology; D013848:Thigh