Androgen receptor protein expression in prostatic tissues in Black and Caucasian men.
BACKGROUND
CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon.


METHODS
AR immunostaining was compared in epithelium and PES of normal, BPH, and CaP tissues from Black African men and UK Caucasian men.


RESULTS
AR expression was similar in normal prostatic epithelium of both groups, but was higher in BPH and CaP epithelium of Black than Caucasian men (P </= 0.0001). Also, AR expression in PES was higher in Caucasian than Black men in normal/atrophic and benign hyperplastic tissues, but there was a similar significant loss of AR expression in PES of CaP tissues of both groups (normal and BPH stroma versus CaP stroma (P </= 0.0001).


CONCLUSIONS
Variations in AR expression between subpopulations may contribute to the phenotypic differences of prostatic diseases in Black and Caucasian men.
Olapade-Olaopa
E Oluwabunmi
EO
Department of Urology, Leicester General Hospital, Leicester, United Kingdom. okeoffa@yahoo.com
Muronda
Charles A
CA
MacKay
E Hugh
EH
Danso
Alex P
AP
Sandhu
Davinder P
DP
Terry
Timothy R
TR
Habib
Fouad K
FK
D044383:Black People; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D011467:Prostate / Q000502:physiology*; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000096:biosynthesis*; D044465:White People
D011944:Receptors, Androgen