title: Androgen receptor protein expression in prostatic tissues in Black and Caucasian men.
abstract: BACKGROUND
  CaP has a higher incidence and mortality in Black men. We hypothesized that subpopulation differences in AR expression may contribute to this phenomenon.
  
  
  METHODS
  AR immunostaining was compared in epithelium and PES of normal, BPH, and CaP tissues from Black African men and UK Caucasian men.
  
  
  RESULTS
  AR expression was similar in normal prostatic epithelium of both groups, but was higher in BPH and CaP epithelium of Black than Caucasian men (P </= 0.0001). Also, AR expression in PES was higher in Caucasian than Black men in normal/atrophic and benign hyperplastic tissues, but there was a similar significant loss of AR expression in PES of CaP tissues of both groups (normal and BPH stroma versus CaP stroma (P </= 0.0001).
  
  
  CONCLUSIONS
  Variations in AR expression between subpopulations may contribute to the phenotypic differences of prostatic diseases in Black and Caucasian men.
authors.affiliation: Department of Urology, Leicester General Hospital, Leicester, United Kingdom. okeoffa@yahoo.com
authors.forename: E Oluwabunmi
authors.initials: EO
authors.lastname: Olapade-Olaopa
authors.forename: Charles A
authors.initials: CA
authors.lastname: Muronda
authors.forename: E Hugh
authors.initials: EH
authors.lastname: MacKay
authors.forename: Alex P
authors.initials: AP
authors.lastname: Danso
authors.forename: Davinder P
authors.initials: DP
authors.lastname: Sandhu
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Terry
authors.forename: Fouad K
authors.initials: FK
authors.lastname: Habib
mesh_terms: D044383:Black People; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D011467:Prostate / Q000502:physiology*; D011470:Prostatic Hyperplasia / Q000235:genetics* / Q000503:physiopathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000503:physiopathology*; D011944:Receptors, Androgen / Q000096:biosynthesis*; D044465:White People
chemical_list: D011944:Receptors, Androgen