Serum levels of angiogenic growth factors in patients with thyroid gland tumors and parathyroid adenoma.
OBJECTIVE
Angiogenic growth factors bFGF and VEGF ensure vascularisation of the growing tumor tissue. We decided to investigate their peripheral serum concentrations in patients with thyroid gland adenoma and papillary carcinoma and with parathyroid adenoma. We wanted to find the possible serum marker of these tumor diseases.


METHODS
28 patients with thyroid gland tumor (14x adenoma, 14x papillary carcinoma) and 12 patients with parathyroid gland adenoma. Growth factors serum levels were measured by ELISA method.


RESULTS
We found significantly higher serum levels of bFGF in both groups of patients with thyroid adenoma (4.93 +/- 3.42 ng/ml) and papillary carcinoma (5.69 +/- 5.58 ng/ml) compared to the healthy population (1.47 +/- 1.77 ng/ml). There were no significant differences of VEGF serum levels between all examined groups of patients (adenoma 213 +/- 197, papillary carcinoma 210 +/- 179, healthy 227 +/- 231 pg/ml). We found significantly higher serum levels of bFGF in patients with parathyroid gland adenoma (7.59 +/- 9.12 ng/ml) compared to those in healthy people (1.47 +/- 1.77 ng/ml).


CONCLUSIONS
Higher bFGF serum concentrations in patients with thyroid and parathyroid tumors are in accordance with their immunohistochemical tissue levels described in the literature. Not so in VEGF. bFGF may be a serum marker of thyroid and parathyroid neoplasms.
Veselý
David
D
Department of Otorhinolaryngology, Head and Neck Surgery. The First Medical Faculty of the Charles University, University Hospital Motol, V Uvalu 84, 150-06 Prague 5, Czech Republic. david_vesely@hotmail.com
Astl
Jaromír
J
Matucha
Petr
P
Sterzl
Ivan
I
Betka
Jan
J
D000236:Adenoma / Q000097:blood*; D015415:Biomarkers; D014408:Biomarkers, Tumor; D002291:Carcinoma, Papillary / Q000097:blood; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000097:blood; D010282:Parathyroid Neoplasms / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D015415:Biomarkers; D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2