title: Tbx18 and boundary formation in chick somite and wing development.
abstract: The chicken Tbx gene, Tbx18, is expressed in lateral plate mesoderm, limb, and developing somites. Here we show that Tbx18 is expressed transiently in axial mesenchyme during somite segmentation. We present evidence from overexpression and transplantation experiments that Tbx18 controls fissure formation in the late stages of somite maturation. In presumptive wing lateral plate mesoderm, ectopic Tbx18 expression leads to anterior extension of the wing bud. These results suggest that Tbx18 is involved in producing mesodermal boundaries, generating in paraxial mesoderm morphological boundaries between somites and in lateral plate mesoderm a wing- or non-wing-forming boundary.
authors.affiliation: Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK. mtanaka@uoneiro.uoregon.edu
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Cheryll
authors.initials: C
authors.lastname: Tickle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D008648:Mesoderm / Q000378:metabolism; D008969:Molecular Sequence Data; D019170:Somites / Q000378:metabolism*; D020825:T-Box Domain Proteins; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014921:Wings, Animal / Q000196:embryology* / Q000378:metabolism
chemical_list: D020825:T-Box Domain Proteins; C485324:Tbx18 protein, chicken; C420983:Tbx18 protein, mouse; D014157:Transcription Factors