Early decision; meiotic crossover interference prior to stable strand exchange and synapsis.
During meiosis, DNA double-strand breaks ultimately yield two types of recombinants: crossovers (CO) and noncrossovers (NCO). Recent studies in budding yeast show the CO/NCO designation occurs before stable strand exchange and thus well before Holliday junction resolution. Chromosome synapsis occurs after CO/NCO designation and is not required for the regulated distribution of COs along chromosomes manifested as CO interference.
Bishop
Douglas K
DK
Department of Radiation & Cellular Oncology, University of Chicago, Chicago, IL 60637, USA. dbishop@midway.uchicago.edu
Zickler
Denise
D
D023902:Chromosome Pairing / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics / Q000648:ultrastructure; D004247:DNA / Q000235:genetics*; D045566:DNA, Cruciform / Q000235:genetics*; D008540:Meiosis / Q000235:genetics*; D008958:Models, Molecular; D009154:Mutation / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics
D045566:DNA, Cruciform; D004247:DNA