[Osteopathy in diabetic foot syndrome].
Morphological characteristics of bone tissues were studied in the feet of patients with diabetes mellitus type 1 and 2 (DM1 and DM2). Osteoblasts and osteoclasts prevalence, the presence of collagen type III in the composition of newly formed bone were characteristic for DM1. Osteocytes prevalence and abundant granulation tissue in newly formed bone was a feature of DM2. The analysis of bone tissue resorption suggests that lacunar osteoclastic resorpsion is the main type in DM1 while periosteocytic osteolysis and smooth resorption are typical for DM2. Thus, osteolysis genesis and synthesis of bone tissue in DM1 and DM2 may be different.
Dedov
I I
II
Endocrinological Research Centre, 117036, Moscow.
Iushkov
P V
PV
Tokmakova
A Iu
AIu
Ul'ianova
I N
IN
D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D024042:Collagen Type I / Q000378:metabolism; D024043:Collagen Type II / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D017719:Diabetic Foot / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005353:Fibronectins / Q000378:metabolism; D005529:Foot Bones / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D013577:Syndrome
D024042:Collagen Type I; D024043:Collagen Type II; D005353:Fibronectins