Dealing with multiplicities in pharmacoepidemiologic studies.
The problem of multiplicities arises in almost all aspects of scientific studies. When multiple hypotheses are tested in a study, one must adjust the significance level of individual tests to maintain an overall probability error rate. The reasons for this are explored in a non-technical way. Techniques for dealing with multiplicities are described and motivated and guidelines are given, with implications for both study design and publication.
Rosenberger
W F
WF
Department of Mathematics and Statistics, University of Maryland, Baltimore County, 5401 Wilkens Avenue, Baltimore, MD 21228-5398, USA.