[Usefulness of biological markers in evaluation of smoking].
Tobacco exposure can be assessed by the measurement of several markers in biological fluids. These markers are more or less specific for tobacco and the different methods to measure them out differ in terms of sensibility, specificity, ease of use and cost. The clinician prescribing a dosage for a patient has to take all these parameters into account to make an accurate choice. In this article, we have analysed the usefulness of the main biological tobacco markers in the follow-up of smokers and compared their methods of dosage. We propose several indications and point out the interest of relevant markers to realize objective measurements of smoking habits.
Larramendy
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C
Service de pharmacie, hôpital Albert Chenevier, AP-HP, 40, rue de Mesly, 94000 Créteil, France.
Diviné
C
C
Asnafi-Farhang
S
S
Lagrue
G
G
D000388:Air; D000470:Alkaloids / Q000032:analysis; D016477:Artifacts; D015415:Biomarkers; D002248:Carbon Monoxide / Q000032:analysis / Q000097:blood; D002263:Carboxyhemoglobin / Q000032:analysis; D002845:Chromatography / Q000379:methods; D003124:Colorimetry; D003367:Cotinine / Q000097:blood; D005069:Evaluation Studies as Topic; D005189:False Positive Reactions; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D009538:Nicotine / Q000097:blood / Q000493:pharmacokinetics; D012463:Saliva / Q000737:chemistry; D012680:Sensitivity and Specificity; D012907:Smoking / Q000378:metabolism*; D013861:Thiocyanates / Q000032:analysis / Q000097:blood / Q000652:urine
D000470:Alkaloids; D015415:Biomarkers; D013861:Thiocyanates; D009538:Nicotine; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D003367:Cotinine