title: Noninvasive determination of blood constituents using an array of modulated laser diodes and a photoacoustic sensor head.
abstract: Using photoacoustic laser spectroscopy, the noninvasive determination of blood constituents like hemoglobin and glucose is feasible. The aim of our investigations is the development of a sensor which is suitable for continuously noninvasive monitoring of blood glucose concentrations in diabetic patients. For this purpose a photoacoustic sensor head was developed and coupled via an optical fiber bundle to an array of 8 laser diodes emitting at various wavelengths in the near infrared region. Applying a special modulation scheme, the tiny changes of the absorption coefficient of whole blood caused by the variations of blood glucose concentrations could be measured. A resolution of 70 mg/dl was achieved, a value which is already close to the clinical requirements for a continuously working glucose sensor.
authors.affiliation: Institut für Wasserchemie und Chemische Balneologie, TU München, D-81377, München, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Spanner
authors.forename: R
authors.initials: R
authors.lastname: Niessner