Herpetic eye disease: immunopathogenesis and therapeutic measures.
Infection of the cornea with herpes simplex virus (HSV) can result in a chronic disease called herpetic stromal keratitis (HSK). The disease represents one of the leading causes of infectious blindness in the Western world. Immune-mediated cellular damage is suspected in the pathogenesis of human HSK. The murine model has been pivotal in further establishing HSK as an immunopathological disease. This article reviews understanding of HSK, both in humans and in the mouse model, with an emphasis on possible future therapeutic strategies to counteract this blinding immunoinflammatory disease.
Deshpande
Shilpa
S
Department of Microbiology, M 409, Walters Life Sciences Bldg, 1414 Cumberland Avenue, College of Arts and Sciences, University of Tennessee, Knoxville, TN 37996, USA. shilpakaistha@indiatimes.com
Banerjee
Kaustuv
K
Biswas
Partha Sarathi
PS
Rouse
Barry T
BT
D000818:Animals; D003316:Corneal Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D016510:Corneal Neovascularization; D004195:Disease Models, Animal; D006801:Humans; D016849:Keratitis, Herpetic / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D051379:Mice; D018139:Simplexvirus; D013601:T-Lymphocytes / Q000276:immunology