title: Immunosuppression affects the rate of recurrent primary biliary cirrhosis after liver transplantation.
abstract: Identifying the risk factors associated with recurrence of primary biliary cirrhosis after liver transplantation may affect immunosuppression and increase understanding of the pathogenesis. Four hundred eighty-five patients with PBC were followed for a median of 79 months after transplantation; histological evidence of recurrence was found in 23%. On multivariate analysis, the only risk factor identified with recurrence was the type of calcineurin inhibitor used. The odds ratio for recurrence on tacrolimus was 2.73 (95% confidence interval: 1.84-4.10) compared with cyclosporine. For those receiving cyclosporine, the median time to recurrence was 123 months and for those on tacrolimus 62 months (P <.001). Reasons for this difference between the 2 calcineurin inhibitors are not clear.
authors.affiliation: Liver Unit, Queen Elizabeth Hospital, Birmingham, UK. J.M.Neuberger@bham.ac.uk
authors.forename: James
authors.initials: J
authors.lastname: Neuberger
authors.forename: Bridget
authors.initials: B
authors.lastname: Gunson
authors.forename: Stefan
authors.initials: S
authors.lastname: Hubscher
authors.forename: Peter
authors.initials: P
authors.lastname: Nightingale
mesh_terms: D000328:Adult; D000368:Aged; D019703:Calcineurin; D016572:Cyclosporine / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008105:Liver Cirrhosis, Biliary / Q000209:etiology* / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D004791:Enzyme Inhibitors; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D019703:Calcineurin; D016559:Tacrolimus