title: The use of autoradiography for investigating the distribution of radioactivity in lung counter calibration sources.
abstract: This paper shows that autoradiography is a useful technique for investigating radioactivity distributions in lung phantoms and planar sources. It was applied to a sliced lung phantom that had activity homogeneously distributed throughout the tissue substitute material and to laminated planar sources in an attempt to answer three questions: 1) Was the activity distribution the same in each slice of the sliced homogeneous lung set? 2) Was the activity distribution the same for each of the laminated planar sources? and 3) Were the activity distributions the same between slices and planar sources? The activity distribution, including identification of some locations of elevated activity in the sliced homogeneous lungs, was easily obtained using autoradiography. This study demonstrates that neither the sliced homogeneous lung sets nor the laminated planar sources had a homogeneous distribution of radioactivity, as had been previously thought.
authors.affiliation: Human Monitoring Laboratory, Environmental Radiation Hazards Division, Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, Ontario, K1A 1C1, Canada. Gary_H_Kramer@hc-sc.gc.ca
authors.forename: Gary H
authors.initials: GH
authors.lastname: Kramer
authors.forename: Barry M
authors.initials: BM
authors.lastname: Hauck
authors.forename: Leonora
authors.initials: L
authors.lastname: Marro
authors.forename: Kenneth G W
authors.initials: KG
authors.lastname: Inn
authors.forename: Mike
authors.initials: M
authors.lastname: Unterweger
authors.forename: Pam
authors.initials: P
authors.lastname: Hodge
mesh_terms: D001345:Autoradiography / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D019047:Phantoms, Imaging; D011835:Radiation Protection / Q000295:instrumentation / Q000379:methods; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods*; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity