title: Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection. Method validation.
abstract: An increased frequency of contact allergy to methyldibromoglutaronitrile (MDBGN), a commonly used preservative in cosmetics and other consumer products, has been reported in recent years. A high-performance liquid chromatography (HPLC) method for the determination of MDBGN in cosmetic products has been validated in the present study. The identification is performed by reductive electrochemical detection of the bromine present in the molecule. The method is suitable for compliance testing of cosmetic products as well as for the research to support clinical and epidemiological studies.
authors.affiliation: National Environmental Research Institute, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark. scr@dmu.dk
authors.forename: Suresh Chandra
authors.initials: SC
authors.lastname: Rastogi
authors.forename: Claus
authors.initials: C
authors.lastname: Zachariae
authors.forename: Jeanne D
authors.initials: JD
authors.lastname: Johansen
authors.forename: Charlotte
authors.initials: C
authors.lastname: Devantier
authors.forename: Torkil
authors.initials: T
authors.lastname: Menné
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000032:analysis*; D003877:Dermatitis, Contact; D004563:Electrochemistry; D006801:Humans; D009570:Nitriles / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D012915:Soaps / Q000032:analysis
chemical_list: D003358:Cosmetics; D009570:Nitriles; D012915:Soaps; C039411:1,2-dibromo-2,4-dicyanobutane