title: Field trial of the efficacy of a combination of ivermectin and praziquantel in horses infected with roundworms and tapeworms.
abstract: Two hundred and thirty-three horses were screened for the presence of roundworms by faecal egg counts (FECs) and for tapeworms by an ELISA specific for antibodies to the immunodominant 12 kDa and 13 kDa tapeworms antigen. The 62 horses were found to be infected with both parasites were treated with a combination of 0.2 mg/kg ivermectin and 1.5 mg/kg praziquantel. The treatment suppressed the median FEC of the horses to zero for 10 weeks and significantly reduced their anti-12/13 kDa antibody levels. The estimated risk of tapeworm-associated colic in these horses was halved by 12 weeks after the treatment.
authors.affiliation: Virbac Ltd, Woolpit Business Park, Wind mill Avenue, Bury St Edmunds, Suffolk IP30 9UP.
authors.forename: E J
authors.initials: EJ
authors.lastname: Barrett
authors.forename: J
authors.initials: J
authors.lastname: Farlam
authors.forename: C J
authors.initials: CJ
authors.lastname: Proudman
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D000969:Antinematodal Agents / Q000008:administration & dosage*; D002589:Cestoda; D004359:Drug Therapy, Combination; D004739:England / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005243:Feces / Q000469:parasitology; D006734:Horse Diseases / Q000188:drug therapy* / Q000453:epidemiology* / Q000469:parasitology; D006736:Horses; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage*; D009348:Nematoda; D011223:Praziquantel / Q000008:administration & dosage*; D015995:Prevalence; D013319:Strongyle Infections, Equine / Q000188:drug therapy / Q000453:epidemiology; D016896:Treatment Outcome
chemical_list: D000909:Antibodies, Helminth; D000969:Antinematodal Agents; D011223:Praziquantel; D007559:Ivermectin