title: Bacteremic elder emergency department patients: procalcitonin and white count.
abstract: OBJECTIVE
  To assess serum procalcitonin (PCT) and white blood cell (WBC) count in detecting bacteremia in elder emergency department (ED) patients.
  
  
  METHODS
  A prospective, observational study of ED patients aged > or =65 years in whom blood cultures were drawn was conducted at an urban, tertiary care, academic ED. Serum for PCT and WBC count was obtained at the time of ED visit. Receiver-operating characteristic (ROC) curves, proportions, and likelihood ratios were calculated.
  
  
  RESULTS
  One hundred eight patients met entry criteria, 14 with bacteremia. In comparing bacteremic patients versus all others, PCT > 0.2 ng/mL was 93% sensitive (95% confidence interval [CI] = 79% to 100%) and 38% specific (95% CI = 28% to 48%) with a negative likelihood ratio (LR(-)) of 0.18. Abnormal WBC count was 64% sensitive (95% CI = 39% to 89%) and 54% specific (95% CI = 44% to 64%) with an LR(-) of 0.78. The presence of either abnormal WBC count or left shift was 93% sensitive (95% CI = 74% to 100%) but 11% specific (95% CI = 4% to 11%) with an LR(-) of 0.64. When considering only bacteremic patients versus noninfected patients, PCT at a cutoff of 0.2 ng/mL had an LR(-) of 0.12. Area under a ROC curve was significantly greater for PCT (0.7; 95% CI = 0.6 to 0.9) than for abnormal WBC count (0.5; 95% CI = 0.3 to 0.7; p < 0.05).
  
  
  CONCLUSIONS
  In elder ED patients, a PCT level of 0.2 ng/mL is sensitive for bacteremia and, based on its negative likelihood ratio, is moderately helpful in ruling out the diagnosis. WBC count with or without left shift performed poorly in the diagnosis of bacteremia.
authors.affiliation: Department of Emergency Medicine, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA. jeffreycaterino@hotmail.com
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Caterino
authors.forename: Mark D
authors.initials: MD
authors.lastname: Scheatzle
authors.forename: Michael L
authors.initials: ML
authors.lastname: Forbes
authors.forename: Joyce A
authors.initials: JA
authors.lastname: D'Antonio
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes; D008297:Male; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide