title: Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population-based case-control study.
abstract: BACKGROUND
  Serine proteases play an important role in prostate cancer (PCa) invasion through the degradation of extracellular matrix proteins and interaction with growth modulating factors. The transmembrane serine protease 2 (TMPRSS2) gene encodes a type II transmembrane protein which, due to its cell surface localization, could be a potentially useful predictive marker for PCa.
  
  
  METHODS
  We screened a population of 24 unrelated individuals for sequence variants in the TMPRSS2 gene, and found a Met160Val change in 33%. We then tested 559 cases and 523 controls from a population-based case-control study of middle-aged men from Washington State.
  
  
  RESULTS
  Men with the GG genotype and a first-degree family history of PCa had a significantly higher risk for PCa relative to men without a family history (OR = 2.05; 95% CI = 1.3-3.2). However, the interaction between genotype and family history of PCa was not significant (P = 0.52).
  
  
  CONCLUSIONS
  Larger, more detailed studies are needed to fully investigate the role of serine proteases in PCa.
authors.affiliation: Division of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Lubieniecka
authors.forename: Mahesh Keitheri
authors.initials: MK
authors.lastname: Cheteri
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D012697:Serine Endopeptidases; C421305:TMPRSS2 protein, human