Serotonin transporter gene polymorphism and personality traits in primary alcohol dependence.
We tested the hypothesis of an association between the serotonin transporter (5-HTT) gene regulatory region polymorphism and the Temperament and Character Inventory (TCI) personality dimension of Harm Avoidance. For the study, 124 subjects seeking inpatient treatment for primary alcohol dependence were grouped by their 5-HTT genotype and assessed with the TCI. Genotypes differed statistically significantly in Harm Avoidance but not in any other personality trait. This gives support to the hypothesis that the TCI temperament Harm Avoidance is associated with serotonergic neurotransmission in primary alcohol dependence.
Wiesbeck
Gerhard A
GA
Department of Substance Use Disorders, Psychiatric University Clinic, University of Basel, Switzerland. gerhard.wiesbeck@pukbasel.ch
Weijers
Heinz-Gerd
HG
Wodarz
Norbert
N
Keller
Heike K
HK
Michel
Tanja M
TM
Herrmann
Martin J
MJ
Boening
Jobst
J
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010554:Personality Disorders / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins; D012720:Severity of Illness Index; D013694:Temperament
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins