title: [The effects of early escharectomy on resting energy expenditure in the severely burned patients].
abstract: OBJECTIVE
  To investigate the effect of early escharectomy on resting energy expenditure (REE) in severely burned patients dynamically with the metabolic monitoring and diagnostic system.
  
  
  METHODS
  Fifty-six adult male patients with severe burns were divided into early escharectomy (group A, n = 39, escharectomy within 5 PBDs) and non-early escharectomy (group B, n = 17, escharectomy after 5 PBDs) groups. The wounds of full thickness and deep partial thickness burn in the two groups were all excised and covered with allogeneic skin and autologous micro-skin in the first operation. The changes in REE were observed dynamically at the bedside of the patients with the metabolic monitoring and diagnostic system. The plasma contents of IL-6, IL-8, TNF-alpha and LPS from 9 patients in group A and 7 in group B were also determined dynamically.
  
  
  RESULTS
  All patients survived. The REE in both groups was elevated markedly, but REE in group A was lower compared with group B before and after escharectomy within 14 days. (P < 0.05). The plasma level of IL-6, IL-8, TNF-alpha and LPS in group A were obviously lower than those in group B (P < 0.05).
  
  
  CONCLUSIONS
  The hypermetabolic response of burn patients with severe burns could be lowered by early escharectomy, and it seemed to be related to the decrease of the release of proinflammatory mediators.
authors.affiliation: Burn Institute, 304th hospital, PLA, Beijing 100037, P.R. China.
authors.forename: Jian-chuan
authors.initials: JC
authors.lastname: Gao
authors.forename: Jia-ke
authors.initials: JK
authors.lastname: Chai
authors.forename: Hong-ming
authors.initials: HM
authors.lastname: Yang
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Sheng
authors.forename: Dai-feng
authors.initials: DF
authors.lastname: Hao
authors.forename: Zhen-rong
authors.initials: ZR
authors.lastname: Guo
mesh_terms: D000328:Adult; D001481:Basal Metabolism; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D011182:Postoperative Care; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha