title: [Nuclear shape assessment of the cells in precancerous lesions and laryngeal cancer].
abstract: The authors assessed morphometrically the nuclei shape of the normal mucosa, precancerous lesions (dysplasia, keratosis) and laryngeal cancer in the postoperative samples of 12 patients treated in the Laryngology Department Silesian Medical Academy in Zabrze. Five slides from the same patient, each 4 um thick were assessed. The histologic samples were measured by system Quantimet 500 + Color Option with magnification 2100x. Roundness, aspect ratio and fullness ratio were evaluated. The relationship among the morphologic lesions using shape descriptors was assessed. In some cases there were no significant differences between the nuclei of mild dysplasia cells and the cells of the normal epithelium. The results indicate significant karyometric shape differences of the normal mucosa, precancerous lesions and cancer of the larynx.
authors.affiliation: Katedra i Klinika Laryngologii Slaskiej AM w Zabrzu.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Scierski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Namysłowski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Nozyński
authors.forename: Ewa
authors.initials: E
authors.lastname: Zembala-Nozyńska
mesh_terms: D000328:Adult; D000368:Aged; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D007620:Karyometry / Q000379:methods; D007642:Keratosis; D007820:Laryngeal Mucosa / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*