title: [The effect of aging on the apparent diffusion coefficient of normal appearing white and gray matter].
abstract: OBJECTIVE
  To test if the apparent diffusion coefficient (ADC) values reflect the ultrastructural changes of normal appearing white and gray matter with advancing age.
  
  
  METHODS
  We selected 45 patients with normal MRI and DW imaging findings. DW and MRI imaging was performed and for each patient the average ADC on trace images of the frontal and occipital white matter and the thalamus were compared with increasing patient age.
  
  
  RESULTS
  The average ADC value was 0.753+/-0.054 x 10-3 mm2/sec in frontal white matter, 0.673+/-0.085 x 10-3 mm2/sec in occipital white matter, and 0.763+/-0.063 x 10-3 mm2/sec in the thalamus. For white matter, ADC values increased with advancing age. Although ADC tended to increase with age, comparison of individual thalamic ADC and patient ages did not reach statistical significance.
  
  
  CONCLUSIONS
  Advancing age is associated with a small but statistically significant increase of water diffusibility in human white matter. This increase may reflect mild structural changes with normal aging.
authors.affiliation: Kirikkale Universitesi Tip Fakültesi, Radyoloji Bölümü, Kirikkale, Turkey.
authors.forename: Yasemin M
authors.initials: YM
authors.lastname: Karadeniz Bilgili
authors.forename: Birsen
authors.initials: B
authors.lastname: Unal
authors.forename: Tuba
authors.initials: T
authors.lastname: Kendi
authors.forename: Ilknur
authors.initials: I
authors.lastname: Simşir
authors.forename: Haydar
authors.initials: H
authors.lastname: Erdal
authors.forename: Sinef
authors.initials: S
authors.lastname: Huvaj
authors.forename: Simay
authors.initials: S
authors.lastname: Kara
authors.forename: G
authors.initials: G
authors.lastname: Bademci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001921:Brain / Q000254:growth & development / Q000473:pathology* / Q000648:ultrastructure*; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged