title: Screening of a large panel of gastrointestinal peptide plasma levels is not adapted for the evaluation of digestive damage following irradiation.
abstract: The aim of this study was to assess the potential of gastrointestinal peptide plasma levels as biomarkers of radiation-induced digestive tract damage. To this end, plasma levels of substance P, GRP, motilin, PYY, somatostatin-28, gastrin, and neurotensin were followed for up to 5 days in pigs after a 16-Gy whole-body X-irradiation, completed by a histopathological study performed at 5 days. Each peptide gave a specific response to irradiation. The plasma levels of GRP and substance P were not modified by irradiation exposure; neither were those of motilin and PYY. Concerning gastrin, a 2-3-fold increase of plasma concentration was observed in pig, which presented the most important histological alterations of the stomach. The plasma levels of somatostatin, unchanged from 1 to 4 days after irradiation, was also increased by 130% at 5 days. In contrast, a diminution of neurotensin plasma levels was noted, firstly at 1 day (-88%), and from 3 days after exposure (-50%). The present study suggested that changes in gastrin and neurotensin plasma levels were associated with structural alterations of the stomach and ileum, respectively, indicating that they may be relevant biological indicators of radiation-induced digestive damage to these segments.
authors.affiliation: Institut de Radioprotection et de Sûreté Nucléaire, Direction de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidemiologie, IRSN, BP 17, F-92262 CEDEX Fontenay-aux-Roses, France. isabelle.dublineau@irsn.fr
authors.forename: I
authors.initials: I
authors.lastname: Dublineau
authors.forename: N
authors.initials: N
authors.lastname: Dudoignon
authors.forename: P
authors.initials: P
authors.lastname: Monti
authors.forename: O
authors.initials: O
authors.lastname: Combes
authors.forename: J
authors.initials: J
authors.lastname: Wysocki
authors.forename: S
authors.initials: S
authors.lastname: Grison
authors.forename: C
authors.initials: C
authors.lastname: Baudelin
authors.forename: N M
authors.initials: NM
authors.lastname: Griffiths
authors.forename: P
authors.initials: P
authors.lastname: Scanff
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D004066:Digestive System Diseases / Q000503:physiopathology*; D019886:Gastrin-Releasing Peptide / Q000097:blood; D005755:Gastrins / Q000097:blood; D041981:Gastrointestinal Tract / Q000503:physiopathology / Q000528:radiation effects*; D007082:Ileum / Q000528:radiation effects; D007150:Immunohistochemistry; D008297:Male; D009037:Motilin / Q000097:blood; D009496:Neurotensin / Q000097:blood; D019894:Peptide YY / Q000097:blood; D010455:Peptides / Q000097:blood*; D011832:Radiation Injuries / Q000503:physiopathology*; D013004:Somatostatin / Q000097:blood; D053561:Somatostatin-28; D013270:Stomach / Q000528:radiation effects; D013373:Substance P / Q000097:blood; D013552:Swine
chemical_list: D015415:Biomarkers; D005755:Gastrins; D010455:Peptides; D019894:Peptide YY; D013373:Substance P; D009496:Neurotensin; D013004:Somatostatin; D009037:Motilin; D053561:Somatostatin-28; D019886:Gastrin-Releasing Peptide