Effects of sex, age and BMI on screening tests for impaired glucose tolerance.
The discriminating abilities of fasting plasma glucose (FPG) and HbA1c were compared on screening tests for impaired glucose tolerance (IGT) and IGT plus diabetes mellitus by the receiver operating characteristic (ROC) curve analysis. Furthermore, effects of sex, age and BMI were examined on sensitivity and specificity of the optimal cutoff points. This study included 997 subjects who were recruited for 75 g OGTT after the first screening of the Japan Diabetes Prevention Program. According to the 1997 criteria of the American Diabetes Association (ADA), 140 subjects were classified as diabetic and 256 as IGT. The areas under the ROC curves of FPG were significantly larger than those of HbA1c. The optimal cutoff points of FPG were 102 mg/dl for IGT and 105 mg/dl for IGT plus diabetes mellitus. Those of HbA1c were both 5.3%. In screening with FPG, females had significantly lower sensitivity and higher specificity than males, and the specificity for IGT plus diabetes mellitus was the lowest in the obese group. In screening with HbA1c, the specificity was low in the older and the obese groups. We concluded that FPG was superior to HbA1c for screening of IGT and IGT plus diabetes mellitus and the optimal cutoff point of FPG would be 102 mg/dl or greater.
Gomyo
Mioko
M
Division of Molecular Epidemiology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Sakane
Naoki
N
Kamae
Isao
I
Sato
Shigeaki
S
Suzuki
Ken-Ichi
K
Tominaga
Makoto
M
Kawazu
Shoji
S
Yoshinaga
Hideyo
H
Tsushita
Kazuyo
K
Sato
Juichi
J
Sato
Yuzo
Y
Tsujii
Satoru
S
Yoshida
Toshihide
T
Seino
Yutaka
Y
Usui
Takeshi
T
Nanjo
Kishio
K
Hirata
Mari
M
Kotani
Kazuhiko
K
Hososako
Arimasa
A
Kiyohara
Yutaka
Y
Kuzuya
Hideshi
H
D000328:Adult; D000375:Aging; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D005215:Fasting / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012372:ROC Curve; D012727:Sex Characteristics
D001786:Blood Glucose; D006442:Glycated Hemoglobin