Chemokine RANTES promoter polymorphisms in allergic rhinitis.
OBJECTIVE
RANTES is one of the most widely studied of the chemokines linked to allergic diseases. Two polymorphisms of the RANTES promoter region (-403 G/A and -28 C/G) have been found. The authors investigated whether these RANTES promoter polymorphisms were associated with allergic rhinitis.


METHODS
Case-control study.


METHODS
Blood samples for genetic analysis were obtained from 151 individuals with allergic rhinitis and from 278 healthy individuals without atopic disease. Polymerase chain reaction-based assays for detection of the -403 G/A and -28 C/G polymorphisms of the RANTES gene were used for genotyping.


RESULTS
The frequencies of both the RANTES -403A and -28G alleles were significantly higher in patients with allergic rhinitis than in control subjects (P <.05 for both).


CONCLUSIONS
The study results indicated that the -403 and -28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis.
Kim
Jeong Joong
JJ
Department of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea.
Lee
Jung Hun
JH
Jang
Chul Ho
CH
Kim
Yong Shin
YS
Chae
Soo Cheon
SC
Chung
Hun Taeg
HT
Choi
Tae Wook
TW
Lee
Jae Hoon
JH
D000328:Adult; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D039981:Pyroglyphidae / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D019914:Taq Polymerase / Q000235:genetics
D018946:Chemokine CCL5; D017931:DNA Primers; D019914:Taq Polymerase