title: Influence of optic edge design and anterior capsule polishing on posterior capsule fibrosis.
abstract: OBJECTIVE
  To evaluate the role of posterior optic edge design and the effect of anterior capsule polishing on peripheral fibrotic posterior capsule opacification (PCO).
  
  
  METHODS
  Department of Ophthalmology, University of Vienna, Vienna, Austria.
  
  
  METHODS
  This randomized prospective study comprised 144 eyes of 72 patients with bilateral age-related cataract. Each patient had standardized cataract surgery in both eyes by the same surgeon. Group 1 (46 patients) received a round-edged hydrophobic acrylic IOL (AMO Sensar AR40) in 1 eye and a sharp-edged hydrophobic acrylic IOL (AMO Sensar OptiEdge AR40e) in the other eye. Group 2 (26 patients) received a silicone IOL (Pharmacia CeeOn 911A) with a truncated optic in both eyes. In this group, the anterior capsule was extensively polished in 1 eye and was left unpolished in the other eye. Digital slitlamp photographs were taken 1 year postoperatively using a standardized photographic technique for fibrotic PCO. The intensity of PCO was subjectively graded (score 0 to 4) by 2 masked examiners.
  
  
  RESULTS
  Subjective PCO scores correlated well between the 2 examiners (r = 0.88). In Group 1, the mean PCO score was 0.26 for the OptiEdge AR40e IOL and 0.90 for the AR40 IOL (P<.01). In Group 2, the mean PCO score was 0.24 in eyes with a polished capsule and 0.17 in eyes in which the capsule was not polished (P =.31).
  
  
  CONCLUSIONS
  The sharp-edged OptiEdge AR40e IOL led to significantly less peripheral fibrotic PCO 1 year postoperatively than the round-edged AR40 IOL. In eyes with the sharp-edged silicone 911A IOL, anterior capsule polishing caused no significant difference in fibrotic PCO.
authors.affiliation: Department of Ophthalmology, University of Vienna, Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
authors.forename: Michael
authors.initials: M
authors.lastname: Georgopoulos
authors.forename: Wolf
authors.initials: W
authors.lastname: Buehl
authors.forename: Katharina
authors.initials: K
authors.lastname: Kriechbaum
authors.forename: Georg
authors.initials: G
authors.lastname: Rainer
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D001672:Biocompatible Materials; D002386:Cataract / Q000209:etiology*; D005355:Fibrosis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery*; D019654:Lens Implantation, Intraocular / Q000379:methods; D007910:Lenses, Intraocular; D018918:Phacoemulsification / Q000379:methods; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D012826:Silicone Elastomers
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D012826:Silicone Elastomers