A new concept for detection of Bence Jones proteinuria in patients with monoclonal gammopathy.
Bence Jones (free light chain-FLC) proteinuria is usually detected by immunofixation electrophoresis (IFE) of urine. With a new, automated immunoassay, it is now possible to quantify FLC in serum and urine. In the present study, we compared different routine methods for monoclonal FLC screening. From our results we conclude that the measurement of FLC in serum is highly sensitive and should replace urine tests. Additionally, possible kidney dysfunction, caused by nephrotoxicity of FLC, should be assessed by urine protein analysis and cystatin C measurements.
Hofmann
Walter
W
Institut Klinische Chemie und Immunologie, Städlisches Krankenhaus München-Neuperlach, Germany. hofmann@extern.lrz-muenchen.de
Garbrecht
Manfred
M
Bradwell
Arthur R
AR
Guder
Walter G
WG
D001322:Autoanalysis; D001536:Bence Jones Protein / Q000276:immunology / Q000652:urine*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007146:Immunoglobulin lambda-Chains / Q000097:blood* / Q000652:urine*; D008403:Mass Screening / Q000379:methods; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis / Q000652:urine; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein