Case of complete recovery of pancytopenia after treatment of hypopituitarism.
We describe a 55-year-old woman who presented with pancytopenia with a normocytic and normochromic anemia which was progressive despite conventional treatments such as folic acid, vitamin B6, and oxymetholone. Her physical findings and history of a previous massive postpartum hemorrhage suggested Sheehan's syndrome, and the pituitary hormonal studies revealed panhypopituitarism. After 4 months of thyroxine and glucocorticoid replacement therapy, her pancytopenia and bone marrow hypoplasia recovered completely. Pancytopenia is a rare manifestation of a hormonal abnormality, but hematologists need to be aware of panhypopituitarism as a differential diagnosis when women showing features of hypopituitarism present with pancytopenia because it can be reversed with adequate hormone replacement.
Kim
Dae-Young
DY
Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong, Jongro-gu, 110-744, Seoul, Korea.
Kim
Jee Hyun
JH
Park
Young Joo
YJ
Jung
Kyung Hae
KH
Chung
Hee Sun
HS
Shin
Soo
S
Yun
Sung-Soo
SS
Park
Seonyang
S
Kim
Byoung Kook
BK
D000740:Anemia / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D001855:Bone Marrow Diseases / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology*; D012658:Sella Turcica / Q000473:pathology; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome
D005938:Glucocorticoids; D013974:Thyroxine