title: Progressive decrease of hepatitis B in a cohort of drug users followed over a period of 15 years: the impact of anti-HBV vaccination.
abstract: In the Western world, the population at the highest risk of HBV infection is probably that of illicit drug users (DUs). Since 1985, 1 Public Health Centre for Drug Users (PHCDU), in north-eastern Italy, has been asking all heroin DUs, whether in treatment or not, to undergo screening for HIV, HBV and, since 1989, for HCV infection. Since 1988 the Centre has proposed HBV vaccination to all patients who were negative for all HBV markers. From 1985 to 2001 895 heroin DUs were screened, 726 males and 169 females. 442 (49.4%) were negative to HBV markers at the first control and 72.4% received at least 1 dose of the vaccine. 320 DUs were vaccinated and a total of 995 doses of recombinant vaccine were administered. The anti-HBc antibody appeared in 2 vaccinated patients out of 258 DUs undergoing controls, while 13 seroconversions for anti-HBc occurred in 45 DUs who had refused to be vaccinated. On the basis of these results, HBV vaccination of DUs can be strongly recommended. Vaccination showed a good adherence in a population difficult to treat and can have a leading role in reducing HBV infection in DUs and their contacts.
authors.affiliation: Medical Service for Addictive Disorders, Department of Internal Medicine, Policlinico GB Rossi, University of Verona, Italy. fabio.lugoboni@azosp.vr.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Lugoboni
authors.forename: Sabrina
authors.initials: S
authors.lastname: Migliozzi
authors.forename: Paolo
authors.initials: P
authors.lastname: Mezzelani
authors.forename: Benedetta
authors.initials: B
authors.lastname: Pajusco
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ceravolo
authors.forename: Gianluca
authors.initials: G
authors.lastname: Quaglio
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005260:Female; D006306:Health Surveys; D006509:Hepatitis B / Q000453:epidemiology* / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage*; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D018570:Risk Assessment; D017678:Sex Distribution; D015819:Substance Abuse, Intravenous / Q000150:complications*; D014611:Vaccination / Q000592:standards*
chemical_list: D017325:Hepatitis B Vaccines