Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition.
Increasing evidence demonstrates that there is marked damage and dysfunction not only in the gray matter but also in the white matter in Alzheimer's disease (AD). In this study, transgenic mice overexpressing beta-amyloid precursor protein (APP) under control of the platelet-derived growth factor promoter (PDAPP mice) were examined using diffusion tensor magnetic resonance imaging (DTI) to evaluate the extent of white matter injury before and following the development of AD-like pathology. The profile of DTI parameters was significantly different in old PDAPP mice compared to that of old control mice following the development of AD-like pathology. No difference in DTI parameters was observed between the young PDAPP and control mice. Our results suggest that as amyloid beta (Abeta) deposition and levels increase over time in PDAPP mice, these changes lead to primary or secondary white matter injury that can be detected by DTI.
Song
Sheng-Kwei
SK
Department of Chemistry, Washington University, St. Louis, MO 63130, USA. victor@wuchem.wustl.edu
Kim
Joong Hee
JH
Lin
Shiow-Jiuan
SJ
Brendza
Robert P
RP
Holtzman
David M
DM
D000375:Aging; D000544:Alzheimer Disease / Q000473:pathology*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000648:ultrastructure; D010982:Platelet-Derived Growth Factor / Q000235:genetics; D011401:Promoter Regions, Genetic
D016564:Amyloid beta-Protein Precursor; D010982:Platelet-Derived Growth Factor