title: CD4+ effector T cell distribution in vivo: TGF-beta 1/TGF-beta receptor II interaction during activation mediates accumulation in the target tissue by preferential proliferation.
abstract: CD4(+) effector T cells generated in mesenteric lymph nodes (mLN) leave into the blood. Although they enter many tissues, mLN effector T cells are later found preferentially in the gut,the drainage area of mLN. We show in the rat that this is not an intrinsic property of mLN T cells. Instead, within the mLN milieu T cells are instructed by cytokines such as transforming growth factor beta 1 (TGF-beta 1) to up-regulate TGF-beta receptor II (TGF-beta RII) during activation. This enables effector T cells to continue proliferation upon subsequent contact with TGF-beta 1 in mLN and gut, and to accumulate in the lymph node draining area, the most likely site of pathogen invasion.
authors.affiliation: Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany. Bode.Ulrike@MH-Hannover.de
authors.forename: Ulrike
authors.initials: U
authors.lastname: Bode
authors.forename: Kerstin
authors.initials: K
authors.lastname: Tiedemann
authors.forename: Jürgen
authors.initials: J
authors.lastname: Westermann
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D008198:Lymph Nodes / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D008643:Mesentery / Q000276:immunology*; D051381:Rats; D018125:Receptors, Transforming Growth Factor beta / Q000276:immunology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000276:immunology; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2
chemical_list: D018125:Receptors, Transforming Growth Factor beta; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2