Graves' ophthalmopathy evolution studied by MRI during childhood and adolescence.
Pediatric patients with Graves' disease (n=26) were studied longitudinally by magnetic resonance imaging of the orbits, allowing an assessment of the enlargement of the extraocular muscles and orbital volume variations. The positive outcome of Graves' ophthalmopathy correlated with low TRAb (autoantibodies to thyroid-stimulating hormone receptor) titers at diagnosis and during follow-up and with prepubertal condition at diagnosis.
Antoniazzi
Franco
F
Pediatric Clinic and Radiology Department, Policlinico Giambattista Rossi, University of Verona, Piazza Ludovico Antonio Scuro 10, I-37134 Verona, Italy. franco.antoniazzi@univr.it
Zamboni
Giorgio
G
Cerini
Roberto
R
Lauriola
Silvana
S
Dall'Agnola
Alberto
A
Tatò
Luciano
L
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005094:Exophthalmos / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D009801:Oculomotor Muscles / Q000254:growth & development / Q000473:pathology; D009915:Orbit / Q000254:growth & development / Q000473:pathology*; D011627:Puberty / Q000502:physiology; D011989:Receptors, Thyrotropin / Q000097:blood; D012016:Reference Values
D011989:Receptors, Thyrotropin