[Peptide histidine-isoleucine and and its human analogue peptide histidine-methionine: localization, receptors and biological function].
Peptide histidine-isoleucine (PHI) and its human analogue peptide histidine-methionine (PHM) are members of a superfamily of structurally related peptides embracing, among others, pituitary adenylate cyclase-activating polypeptide (PACAP), vasoactive intestinal peptide (VIP), peptide histidine-valine (PHV), and helodermin. All the peptides display a pleiotropic biological activity. PHI, PHM, PHV and VIP are co-synthesized from the same precursor and share high levels of structural and functional similarity. These peptides may act through common receptors and are widely distributed throughout the body tissues (the central nervous system, gastrointestinal tract, respiratory system, and reproductive system); however, their role remains largely unknown. Changes in the levels of the peptides in the course of different diseases suggest their possible importance and usefulness in diagnostics. Moreover, the neurotrophic and neuroprotective properties of PHI suggest, by analogy to VIP or PACAP, its therapeutic potential in many neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.
Dejda
Agnieszka
A
Centrum Biologii Medycznej i Mikrobiologii, Polska Akademia Nauk, Łódź.
Matczak
Izabela
I
Nowak
Jerzy Z
JZ
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002645:Chickens; D005399:Fishes; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D010451:Peptide PHI / Q000737:chemistry / Q000502:physiology*; D051381:Rats; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone / Q000378:metabolism; D018005:Receptors, Vasoactive Intestinal Peptide / Q000378:metabolism; D051239:Receptors, Vasoactive Intestinal Peptide, Type II; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I; D013045:Species Specificity; D013552:Swine; D014421:Turkey
D010451:Peptide PHI; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone; D018005:Receptors, Vasoactive Intestinal Peptide; D051239:Receptors, Vasoactive Intestinal Peptide, Type II; D051238:Receptors, Vasoactive Intestinal Polypeptide, Type I