title: Sulfur-directed synthesis of enantiopure hydroxy 2-sulfinyl butadienes.
abstract: The treatment of sulfinyl chlorohydrins with KO-t-Bu in THF generates epoxy vinyl sulfoxides that undergo an efficient base-induced rearrangement to generate enantiopure hydroxy 2-sulfinyl dienes. This novel process takes place with high chemo- and stereoselectivity. The chirality at sulfur effectively controls the geometry of the trisubstituted alkene.
authors.affiliation: Instituto de Química Orgánica, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. iqofp19@iqog.csic.es
authors.forename: Roberto
authors.initials: R
authors.lastname: Fernández de la Pradilla
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Buergo
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Martínez
authors.forename: Carlos
authors.initials: C
authors.lastname: Montero
authors.forename: Mariola
authors.initials: M
authors.lastname: Tortosa
authors.forename: Alma
authors.initials: A
authors.lastname: Viso