title: [Ticlopidine-induced acute cholestatic hepatitis. A case report].
abstract: A case of acute cholestatic hepatitis associated with use of antiplatelet agent ticlopidine is reported. Hepatitis developed 3 weeks after the beginning of the drug in a 72 year old man submitted to coronary angioplasty and stent implantation for unstable angina. The close time relationship between the administration of this antiplatelet drug and the acute onset of liver damage, the exclusion of other hepatobiliary disease and the progressive normalisation of biochemical parameters following withdrawal of the drug strongly suggest that ticlopidine was involved in the pathogenesis of this syndrome.
authors.affiliation: Divisione di Medicina Interna, Ospedale San Sebastiano, Correggio, ASL di Reggio Emilia.
authors.forename: Alberto
authors.initials: A
authors.lastname: Gandolfi
authors.forename: Marco
authors.initials: M
authors.lastname: Mengoli
authors.forename: Edda
authors.initials: E
authors.lastname: Rota
authors.forename: Stefano
authors.initials: S
authors.lastname: Tolomelli
authors.forename: Gianni
authors.initials: G
authors.lastname: Zanghieri
authors.forename: Maria Vilma
authors.initials: MV
authors.lastname: Bernini
authors.forename: Luciano
authors.initials: L
authors.lastname: Lusetti
mesh_terms: D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects*
chemical_list: D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine