title: Improvement in solubility and dissolution rate of flavonoids by complexation with beta-cyclodextrin.
abstract: The inclusion into the beta-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of beta-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were obtained in a molar ratio of 1:1 and their dissolution behavior at different pH was examined.
authors.affiliation: Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università degli Studi di Messina, Viale Annunziata, 98168 Messina, Italy.
authors.forename: Silvana
authors.initials: S
authors.lastname: Tommasini
authors.forename: Daniela
authors.initials: D
authors.lastname: Raneri
authors.forename: Rita
authors.initials: R
authors.lastname: Ficarra
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Calabrò
authors.forename: Rosanna
authors.initials: R
authors.lastname: Stancanelli
authors.forename: Paola
authors.initials: P
authors.lastname: Ficarra
mesh_terms: D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism*; D012995:Solubility; D012996:Solutions; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D005419:Flavonoids; D012996:Solutions; D047392:beta-Cyclodextrins; C031215:betadex