Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.
We report a linezolid-resistant Enterococcus faecalis infection in a cord blood stem cell transplant recipient previously treated with linezolid for bloodstream infections by vancomycin-resistant enterococci. Sequencing showed a G2576U mutation in the 23S rRNA gene. Because of the important niche of linezolid in cancer treatment, linezolid-resistant E. faecalis is noteworthy.
Dibo
Imad
I
Department of Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Pillai
Satish K
SK
Gold
Howard S
HS
Baer
Maria R
MR
Wetzler
Meir
M
Slack
James L
JL
Hazamy
Peggy A
PA
Ball
Donna
D
Hsiao
Chiu Bin
CB
McCarthy
Philip L
PL
Segal
Brahm H
BH
D000081:Acetamides / Q000494:pharmacology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D017422:Sequence Analysis, DNA; D033581:Stem Cell Transplantation / Q000009:adverse effects*
D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D012338:RNA, Ribosomal, 23S; D000069349:Linezolid