title: Use of the Trellis Peripheral Infusion System for enhancement of rt-PA thrombolysis in acute lower limb ischemia.
abstract: The Trellis Peripheral Infusion System is an over-the-wire 0.035" guidewire compatible device, designed to isolate a region of the peripheral vasculature to allow for lytic drug infusion and dispersion. We used it successfully through a percutaneous approach in two cases of acute thrombosis of a native lower limb artery. The total amount of rt-PA used was 12 and 9 mg, respectively and was delivered through bolus injections obviating the need for a supplementary continuous infusion of the agent. The time for dissolution of thrombus was 45 and 35 minutes, respectively. No complications were observed.
authors.affiliation: Department of Radiology, University Hospital of Heraklion, Medical School of Crete, Heraklion-Stavrakia, Greece. tsetis@med.uoc.gr
authors.forename: Dimitrios K
authors.initials: DK
authors.lastname: Tsetis
authors.forename: Asterios N
authors.initials: AN
authors.lastname: Katsamouris
authors.forename: Zacharias
authors.initials: Z
authors.lastname: Androulakakis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Chamalakis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kostas
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Chlapoutakis
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Gourtsoyiannis
mesh_terms: D000208:Acute Disease; D000368:Aged; D005343:Fibrinolytic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007260:Infusion Pumps; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D015912:Thrombolytic Therapy / Q000295:instrumentation*; D013927:Thrombosis / Q000150:complications; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator