Tumour suppression: disruption of HAUSP gene stabilizes p53.
Cummins
Jordan M
JM
Howard Hughes Medical Institute, The Sidney Kimmel Comprehensive Cancer Center, and Program in Cellular and Molecular Medicine, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.
Rago
Carlo
C
Kohli
Manu
M
Kinzler
Kenneth W
KW
Lengauer
Christoph
C
Vogelstein
Bert
B
D000483:Alleles; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7; D015854:Up-Regulation
D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D025801:Ubiquitin; D010450:Endopeptidases; C464569:USP7 protein, human; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7