Rapid gas chromatography-mass spectrometry screening method for human pharmaceuticals, hormones, antioxidants and plasticizers in water.
A rapid gas chromatography-mass spectrometry (GC-MS) method was developed and validated allowing quantification at the ng/l level of 19 analytes in water including human pharmaceuticals, hormones, antioxidants and a plasticizer. On-line continuous liquid-liquid extraction with dichloromethane of 10-401 unfiltered water samples was used to achieve a 10000-40000-fold concentration factor. No sample cleanup or derivatization was required. Recoveries ranged from 57 to 120%. Application of the method to water recycling plant effluent demonstrated the presence of nearly all targeted compounds at ng/l to microgram/l levels. Screening for nontarget compounds in the treated effluent samples indicated the method could be readily extended to include additional analytes.
Soliman
Mary A
MA
Department of Environmental Health Sciences, University of California Los Angeles, CHS 46-081, Charles E. Young Drive South, Los Angeles, CA 90095, USA.
Pedersen
Joel A
JA
Suffet
I H Mel
IH
D000975:Antioxidants / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006728:Hormones / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010968:Plasticizers / Q000032:analysis*; D015203:Reproducibility of Results; D014867:Water / Q000737:chemistry*
D000975:Antioxidants; D006728:Hormones; D004364:Pharmaceutical Preparations; D010968:Plasticizers; D014867:Water