title: The immune response to AIDS virus infection: good, bad, or both?
abstract: A potent antigen-specific T cell response to HIV infection can contribute to the control of viral replication and is therefore beneficial to the host. However, HIV-mediated increases in generalized T cell activation also appear to accelerate both viral replication and CD4+ T cell depletion. A new study in the JCI attempts to experimentally distinguish the beneficial versus harmful aspects of this immune response.
authors.affiliation: Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Deeks
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D019562:Viral Load
chemical_list: D000276:Adjuvants, Immunologic