The pathogenesis underlying the interaction of HIV and herpes simplex virus after co-infection.
An elucidation of the mechanisms of herpes simplex virus type 2 (HSV-2)/HIV co-infection, including studies of the immunohistochemistry of co-infected lesions, co-infection of dendritic cells, confirmation and/or determination of the mechanism of keratinocyte co-infection, should allow targeting with specific interventions, such as the tailoring of microbicides, to HSV-2/HIV co-infection rather than to HIV infection alone. This could be especially important in countries where the HSV seroprevalence is very high, for example in Central Africa, where HSV-2 may stimulate HIV transmission in more than 40% of cases.
Cunningham
Anthony L
AL
Centre for Virus Research, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia.
Dwyer
Dominic E
DE
D006678:HIV / Q000472:pathogenicity*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000821:virology*; D006558:Herpes Genitalis / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000472:pathogenicity*; D006801:Humans