Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population.
Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample.
Ambrósio
Alda M
AM
Department of Neurochemistry, Faculty of Medicine, Center for Neuroscience of Coimbra, University of Coimbra, 3004-517 Coimbra, Portugal. aldachico@yahoo.com
Kennedy
James L
JL
Macciardi
Fabio
F
Macedo
António
A
Valente
José
J
Dourado
Ana
A
Oliveira
Catarina R
CR
Pato
Carlos
C
D002391:Catchment Area, Health; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011174:Portugal / Q000453:epidemiology; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3