title: Differential production of two antibiotics of Streptomyces coelicolor A3(2), actinorhodin and undecylprodigiosin, upon salt stress conditions.
abstract: Production of two pigmented antibiotics, actinorhodin and undecylprodigiosin, is differentially affected in Streptomyces coelicolor A3(2) at high salt concentration, with actinorhodin being inhibited and undecylprodigiosin activated. Analysis of expression of two genes coding for pathway-specific transcriptional regulators of actinorhodin and undecylprodigiosin synthesis, actII-ORF4 and redD, revealed that their expression is similarly differentially affected. Thus, the effect of high salt concentration on actinorhodin and undecylprodigiosin production is mediated at the transcriptional level by the differential expression of genes encoding corresponding pathway-specific transcriptional regulators.
authors.affiliation: Centre of Excellence for Molecular Medicine, Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska cesta 21, 845 51 Bratislava, Slovak Republic.
authors.forename: Beatrica
authors.initials: B
authors.lastname: Sevcikova
authors.forename: Jan
authors.initials: J
authors.lastname: Kormanec
mesh_terms: D000880:Anthraquinones / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D009997:Osmotic Pressure; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000378:metabolism*; D012329:RNA, Bacterial / Q000235:genetics / Q000378:metabolism; D012965:Sodium Chloride; D013302:Streptomyces / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D000095622:Benzoisochromanequinones
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D011353:Prodigiosin; D012329:RNA, Bacterial; D012965:Sodium Chloride; C047347:undecylprodigiosin; C013390:actinorhodin; D000095622:Benzoisochromanequinones