Bone marrow stromal cell implantation for peripheral nerve repair.
Cell therapy using bone marrow stromal cells is a new promising therapy for regenerative medicine. Previous studies demonstrated that local bone marrow stromal cells implantation in the distal stump of transected sciatic nerve of rats promotes early functional recovery. The purpose of this study was to expand on the preliminary research by investigating the long-term efficacy of bone marrow stromal cells using the same experimental setting. Functional test and histological studies demonstrate that bone marrow stromal cell-treated rats exhibit significant improvement on a walking tract test at day 180 after surgery compared with control rats. Taken together, these data suggest that bone marrow stromal cell therapy is a safe and effective strategy for peripheral nerve injuries.
Cuevas
Pedro
P
Departamento de Investigación, Servicio de Histología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá de Henares, E-28034-Madrid-Spain. pedro.cuevas@hrc.es
Carceller
Fernando
F
Garcia-Gómez
Ignacio
I
Yan
Ma
M
Dujovny
Manuel
M
D000818:Animals; D016026:Bone Marrow Transplantation / Q000379:methods*; D008297:Male; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000473:pathology* / Q000637:transplantation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020426:Sciatic Neuropathy / Q000473:pathology / Q000601:surgery*; D017154:Stromal Cells / Q000637:transplantation*