title: The effect of hyperbaric oxygen therapy on the bout of treatment for soft tissue infections.
abstract: OBJECTIVE
  Hyperbaric oxygen (HBO) therapy is often combined with antibiotic therapy for infections such as gas gangrene and osteomyelitis. Although numerous investigations have been undertaken to assess the effect of adjunctive HBO therapy on the treatment of infections, the bout of treatment has not been referred in the previous investigations. The purpose of this retrospective study was to evaluate the efficacy of HBO therapy on the bout of treatment for soft tissue infections.
  
  
  METHODS
  In the period between 1994 and 2001, we treated 23 patients with soft tissue infections. Nine patients were treated with antibiotic chemotherapy alone, and 14 patients were treated with a combination of antibiotic chemotherapy and HBO therapy. The mean bout of treatment was compared between these two groups.
  
  
  RESULTS
  The mean bout treated with a combination of antibiotic and HBO was significantly shorter than that with antibiotic alone.
  
  
  CONCLUSIONS
  Our result indicates that HBO therapy combined with antibiotic therapy is able to shorten the bout of treatment for soft tissue infections. Therefore, we recommend HBO therapy combined with antibiotic therapy for soft tissue infections.
authors.affiliation: Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa City, Saitama 359-8513, Japan. grd1518@gr.ndmc.ac.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugihara
authors.forename: Hironobu
authors.initials: H
authors.lastname: Watanabe
authors.forename: Motoki
authors.initials: M
authors.lastname: Oohashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Kato
authors.forename: Hideaki
authors.initials: H
authors.lastname: Murakami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsukazaki
authors.forename: Kyosuke
authors.initials: K
authors.lastname: Fujikawa
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000378:metabolism; D003131:Combined Modality Therapy; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018461:Soft Tissue Infections / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein