title: Prolonged expression of c-Fos protein in the lateral habenular nucleus of the Japanese monkey (Macaca fuscata) after eye enucleation.
abstract: To elucidate the effect of traumatic stress on the lateral habenular nucleus, we investigated the time course of the expression of c-Fos protein in this nucleus of the Japanese monkey (Macaca fuscata) after enucleation of one eye using c-Fos protein immunocytochemistry. c-Fos protein-like immunoreactive neurons were significantly increased; the increase started 1 h after the enucleation and remained high for 3-9 h in the lateral habenular nucleus on both sides. These results suggest that the prolonged expression of c-Fos protein occurred in the lateral habenular nucleus after traumatic stress through multiple transsynaptic activations.
authors.affiliation: Laboratory for Neuroanatomy, Department of Neurology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
authors.forename: Jamil Ahsan
authors.initials: JA
authors.lastname: Kazi
authors.forename: Shiro
authors.initials: S
authors.lastname: Mori
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuchiiwa
authors.forename: Shiro
authors.initials: S
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000378:metabolism*; D015353:Eye Enucleation / Q000379:methods; D005260:Female; D007839:Functional Laterality; D019262:Habenula / Q000737:chemistry / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008252:Macaca fascicularis; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D040921:Stress Disorders, Traumatic / Q000378:metabolism; D013997:Time Factors
chemical_list: D016760:Proto-Oncogene Proteins c-fos