Effect of adrenomedullin on c-Met receptor expression after reserpine-induced gastric damage in the rat.
Here, we show an increase in c-Met receptor expression during reserpine-induced gastric damage in the rat, as assessed by immunohistochemistry. Pretreatment of animals with adrenomedullin prevented this increase in c-Met expression. c-Met immunoreactivity was localized in gastric glands. c-Met immunoreactivity was associated with increased phosphorylation of c-Met receptor and extracellular signal-regulated kinase (ERK(1/2)). Our results suggest that both adrenomedullin and c-Met act as parallel defence mechanisms during pharmacologically induced gastric mucosa injury.
Martinez
Giuseppa
G
Department of Anatomy, Diagnostics Pathology, Forensic Medicine, Public Health, School of Medicine, University of Catania, Italy.
Cantarella
Giuseppina
G
Cutuli
Vincenza Maria
VM
Loreto
Carla
C
Prato
Agata
A
Lempereur
Laurence
L
Carnazza
Maria Luisa
ML
Amico-Roxas
Matilde
M
Bernardini
Renato
R
Clementi
Giuseppe
G
D053607:Adrenomedullin; D000818:Animals; D000897:Anti-Ulcer Agents; D015153:Blotting, Western; D007150:Immunohistochemistry; D047468:Immunoprecipitation; D008297:Male; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000633:toxicity*; D015398:Signal Transduction / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D014404:Tubulin / Q000096:biosynthesis
D000897:Anti-Ulcer Agents; D010455:Peptides; D011506:Proteins; D014404:Tubulin; D053607:Adrenomedullin; D012110:Reserpine; D019859:Proto-Oncogene Proteins c-met; D020928:Mitogen-Activated Protein Kinases