title: Prenatal diagnosis of congenital Chagas' disease (American trypanosomiasis).
abstract: The prenatal diagnosis of congenital transmission of Chagas' disease in a pregnant woman with the indeterminate form of the disease is reported. Sonography revealed fetal hydrops at 31 weeks' gestation. Anti-Trypanosoma cruzi IgM and IgG antibodies were negative in the fetal blood sampled by cordocentesis, but T. cruzi trypomastigotes were found in its buffy coat. Owing to anemia, in utero exchange transfusion was undertaken, but fetal demise ensued. Labor was induced and a stillborn infant weighing 2030 g was delivered. The pathological examination revealed placentitis and meningoencephalitis, myocarditis and splenitis in the stillborn fetus. Amastigotes were found in the myocardium, brain and placenta.
authors.affiliation: Department of Obstetrics, Faculdade de Medicina da Universidade de São Paulo, Brazil. mariaokumura@hotmail.com
authors.forename: Maria
authors.initials: M
authors.lastname: Okumura
authors.forename: Vera
authors.initials: V
authors.lastname: Aparecida dos Santos
authors.forename: Mário E
authors.initials: ME
authors.lastname: Camargo
authors.forename: Regina
authors.initials: R
authors.lastname: Schultz
authors.forename: Marcelo
authors.initials: M
authors.lastname: Zugaib
mesh_terms: D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001938:Brazil; D014355:Chagas Disease / Q000151:congenital* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D005312:Fetal Blood / Q000469:parasitology; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000469:parasitology*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D010920:Placenta / Q000469:parasitology / Q000473:pathology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000175:diagnosis* / Q000473:pathology; D011296:Prenatal Diagnosis / Q000379:methods; D014349:Trypanosoma cruzi / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M