Therapeutic angiogenesis: the next frontier for interventional radiology.
The field of interventional radiology has traditionally relied on mechanical methods to treat vascular disease, such as angioplasty balloons and stents. Although there have been a number of important technical advances in endovascular devices, there are still a number of patients who are not candidates for percutaneous or surgical revascularization. As we approach the technical limits of these newer devices, therapeutic angiogenesis may play an ever-increasing role in the future. Interventional radiologists have unique delivery skills that would complement the on-going research in this area. It is the goal of this article to serve as a primer for interventional radiologists on the agents and techniques used in this exciting field.
Liddell
Robert P
RP
Russell H. Morgan Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Weiss
Clifford R
CR
Hofmann
Lawrence V
LV
D043925:Angiogenesis Inducing Agents / Q000008:administration & dosage*; D000818:Animals; D003097:Collateral Circulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D015316:Genetic Therapy; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D015641:Radiography, Interventional; D033581:Stem Cell Transplantation
D043925:Angiogenesis Inducing Agents