Prokinetics in the treatment of acute intestinal pseudo-obstruction.
Acute colonic pseudo-obstruction (Ogilvie's syndrome) is characterized by an acute obstruction of the large bowel that is unrelated to mechanical causes. The evidence that cholinesterase inhibitors are effective in relieving acute colonic pseudo-obstruction raised interest in the pharmacological management of this condition. This review analyzes the pharmacological treatment of patients with Ogilvie's syndrome. Intravenous neostigmine is the best pharmacological treatment, leading to rapid colonic decompression. New colokinetic agents, including 5-HT(4) receptor agonists and motilides, may represent other useful therapeutic options for Ogilvie's syndrome.
De Giorgio
Roberto
R
Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna I-40138, Italy. deg@orsola-malpighi.med.unibo.it
Stanghellini
Vincenzo
V
Barbara
Giovanni
G
Guerrini
Stefani
S
Lioce
Andrea
A
Vasina
Valentina
V
Tonini
Marcello
M
Cola
Bruno
B
Corinaldesi
Roberto
R
De Ponti
Fabrizio
F
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D016145:Endoscopy, Digestive System; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D013268:Stimulation, Chemical
D002800:Cholinesterase Inhibitors; D017366:Serotonin Receptor Agonists