[A possible preneoplastic lesion of colorectum].
To investigate KiA10 expression in colorectal cancer and related colorectal tissues.



KiA10 expression was detected by immunohistochemistry in tissue specimens from 101 cases of colorectal cancer and matched cut-margin mucosa and mucosa adjacent to cancers; also in colorectal specimens from 16 cases of ulcerative colitis, 16 of Crohn's disease and 3 healthy subjects.



The positive rate of KiA10 expression in colorectal cancer was 14.85% (15/101); KiA10 positive crypts was demonstrated in 18 cut-margin mucosa and 18 mucosa adjacent to tumors respectively, but they were not matched with each other.



The results suggest that KiA10-positive crypts of the colon might be a preneoplastic lesion.
Lai
Mao-de
MD
Department of Pathology and Pathophysiology, Center for Environmental Genomics, College of Medicine, Zhejiang University, Hangzhou 310031, China. lmp@zju.edu.cn
Huang
Qiong
Q
Parwaresch
Reza
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D034961:Antigens, Nuclear / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*
D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor