Thalidomide as a nitric oxide synthase inhibitor and its structural development.
Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.
Shimazawa
Rumiko
R
Institute of Molecular & Cellular Biosciences, The University of Tokyo, Japan. shimazaw@nihs.go.jp
Sano
Hiroko
H
Tanatani
Aya
A
Miyachi
Hiroyuki
H
Hashimoto
Yuichi
Y
D004791:Enzyme Inhibitors; D007700:Kinetics; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D013792:Thalidomide; D019001:Nitric Oxide Synthase