title: A new concept for detection of Bence Jones proteinuria in patients with monoclonal gammopathy.
abstract: Bence Jones (free light chain-FLC) proteinuria is usually detected by immunofixation electrophoresis (IFE) of urine. With a new, automated immunoassay, it is now possible to quantify FLC in serum and urine. In the present study, we compared different routine methods for monoclonal FLC screening. From our results we conclude that the measurement of FLC in serum is highly sensitive and should replace urine tests. Additionally, possible kidney dysfunction, caused by nephrotoxicity of FLC, should be assessed by urine protein analysis and cystatin C measurements.
authors.affiliation: Institut Klinische Chemie und Immunologie, Städlisches Krankenhaus München-Neuperlach, Germany. hofmann@extern.lrz-muenchen.de
authors.forename: Walter
authors.initials: W
authors.lastname: Hofmann
authors.forename: Manfred
authors.initials: M
authors.lastname: Garbrecht
authors.forename: Arthur R
authors.initials: AR
authors.lastname: Bradwell
authors.forename: Walter G
authors.initials: WG
authors.lastname: Guder
mesh_terms: D001322:Autoanalysis; D001536:Bence Jones Protein / Q000276:immunology / Q000652:urine*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D007146:Immunoglobulin lambda-Chains / Q000097:blood* / Q000652:urine*; D008403:Mass Screening / Q000379:methods; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis / Q000652:urine; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein