Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin.
The factors that contribute to the development of B cell chronic lymphocytic leukemia (B-CLL) are unknown, and the groups of individuals at the greatest risk for developing this common leukemia are not well defined. Molecular features are important for classifying cases of B-CLL, and it is now apparent that similarities among Ig rearrangements between patients may give important clues to the origin of this disease.
Kolar
Grant R
GR
Program in Molecular Immunogenetics, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Capra
J Donald
JD
D001324:Autoantigens / Q000276:immunology; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*
D001324:Autoantigens; D007135:Immunoglobulin Variable Region