Synthesis of conformationally restricted 2,3-diarylbenzo[b]furan by the Pd-catalyzed annulation of o-alkynylphenols: exploring a combinatorial approach.
The palladium/bpy-catalyzed annulation of o-alkynylphenol with various aryl halides to generate diversified 2,3-diarylbenzo[b]furan is herein described. This method provides an efficient synthetic pathway for the combinatorial synthesis of conformationally restricted 2,3-diarylbenzo[b]furan for drug discovery.
Hu
Youhong
Y
VivoQuest, Inc., 711 Executive Boulevard, Valley Cottage, New York 10989, USA.
Nawoschik
Kenneth J
KJ
Liao
Yun
Y
Ma
Jian
J
Fathi
Reza
R
Yang
Zhen
Z
D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism
D001572:Benzofurans; D007202:Indicators and Reagents; D010636:Phenols; D010165:Palladium