[Ibogaine--the substance for treatment of toxicomania. Neurochemical and pharmacological action].
The review of scientific literature, concerning the indol alkaloid Ibogaine, which is extracted from the bush Tabernanthe Iboga, is presented in this article. Used as a stimulating factor for hundred of years in non-traditional medicine, this alkaloid could be important for modern pharmacology because of potential anti-addictive properties. The mechanism of action of this alkaloid is closely related to different neurotransmitting systems. Studies with animals allow concluding that Ibogaine or medicines based on this alkaloid can be used for treatment of drug dependencies.
Kazlauskas
Saulius
S
Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, Kaunas, Lithuania. saulius_kazlauskas@gama.vtu.lt
Kontrimaviciūte
Violeta
V
Sveikata
Audrius
A
D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006213:Hallucinogens / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007050:Ibogaine / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D019966:Substance-Related Disorders / Q000188:drug therapy*; D013997:Time Factors
D018691:Excitatory Amino Acid Antagonists; D006213:Hallucinogens; D007050:Ibogaine