title: Ugi reaction in aqueous solutions: a simple protocol for libraries production.
abstract: A reaction between levulinic acid, isocyanides and primary amines has been examined in distilled water and in surfactants solutions. It is demonstrated that the reaction gives good results at the different concentrations including one well above the solubility limit. A simple and eco-friendly protocol for libraries production is described.
authors.affiliation: Department of Technology of Organic Synthesis (TOSLab), Urals State Technical University, 620002 Ekaterinburg, Russian Federation. mir@htf.ustu.ru
authors.forename: Maxim A
authors.initials: MA
authors.lastname: Mironov
authors.forename: Maria N
authors.initials: MN
authors.lastname: Ivantsova
authors.forename: Vladimir S
authors.initials: VS
authors.lastname: Mokrushin
mesh_terms: D000588:Amines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003486:Cyanides / Q000737:chemistry*; D007982:Levulinic Acids / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000588:Amines; D003486:Cyanides; D007982:Levulinic Acids; C032246:levulinic acid