title: Abnormal coagulation studies associated with levofloxacin. Report of three cases.
abstract: Complications arising from antibiotic use are of interest to neurosurgeons because many neurosurgical patients are treated for infection. In this report, the authors describe three patients with spine disorders who developed coagulopathies after treatment with levofloxacin, an antibiotic commonly used by neurosurgical services. Three patients with spine disorders developed urinary tract infections (UTIs) for which they received a 3-day course of oral levofloxacin. Subsequently, they demonstrated prolonged prothrombin times and increased international normalized ratios. One of those patients later developed acquired von Willebrand syndrome during surgery. Coagulopathies were successfully corrected preoperatively with parenteral vitamin K. The patient with acquired von Willebrand syndrome required multiple transfusions. There seems to be an association between levofloxacin and coagulation abnormalities in neurosurgical patients treated for UTIs. Neurosurgical services prescribing this common antibiotic should be aware of this problem.
authors.affiliation: Department of Neurosurgery, The University of Texas Southwestern Medical Center at Dallas, Texas, USA. tompsarros@aol.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Psarros
authors.forename: Talmadge
authors.initials: T
authors.lastname: Trammell
authors.forename: Kevin
authors.initials: K
authors.lastname: Morrill
authors.forename: Cole
authors.initials: C
authors.lastname: Giller
authors.forename: Howard
authors.initials: H
authors.lastname: Morgan
authors.forename: Beth
authors.initials: B
authors.lastname: Allen
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000139:chemically induced*; D006801:Humans; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000009:adverse effects* / Q000627:therapeutic use*; D013122:Spinal Diseases / Q000150:complications
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin