Miltefosine: an oral drug for visceral leishmaniasis.
Miltefosine, a phosphocholine analogue originally developed as antimalignant drug, has been found to be highly active against leishmania in vitro and animal model. Based on these experiences this drug was tried against human visceral leishmaniasis and found to be highly effective and achieved 97% and 94% cure in phase 2 and phase 3 trial in children.
Prasad
Rajniti
R
Institute of Medical Science, Banaras Hindu University, Varanasi, India. sriharsh2@rediffmail.com
Kumar
Ranjeet
R
Jaiswal
B P
BP
Singh
Utpal Kant
UK
D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*
D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine