title: Fibromuscular dysplasia of the renal artery responsible for renovascular hypertension: a histological presentation based on a series of 102 patients.
abstract: BACKGROUND
  Fibromuscular dysplasia (FMD) is a rare non-atherosclerotic and non-inflammatory disease in the arterial system. The purpose of the study was a retrospective analysis of FMD in the renal artery.
  
  
  METHODS
  A total number of 102 patients (mean age: 36.9 years) who suffered from renovascular hypertension underwent a surgical therapy. The operative specimens of the renal arteries were analysed with the lightmicroscop using histological and immunohistochemical methods.
  
  
  RESULTS
  101 patients (99.02%) presented a medial FMD (extensive-medial subtype in 56 patients, 54.9%, subadventitial subtype in 29 patients, 28.4% and combined subtype in 16 patients, 15.7%). In 1 patient (0.98%) an adventitial FMD was found. We observed the following complications: true and dissecting aneurysms (75 patients, 74.5%), arterio-venous fistulae (2 patients, 1.96%) and chronic thrombosis (10 patients, 9.8%).
  
  
  CONCLUSIONS
  With the progress in angioplasty, not all patients suffering from FMD undergo a primary surgical therapy and therefore this lesion is less seen in the daily work of the histopathologist.
authors.affiliation: Unité d'Anatomie et de Cytologie Pathologiques, Hôpital Saint-Michel, Paris, France.
authors.forename: P N
authors.initials: PN
authors.lastname: Vuong
authors.forename: P
authors.initials: P
authors.lastname: Desoutter
authors.forename: V
authors.initials: V
authors.lastname: Mickley
authors.forename: B
authors.initials: B
authors.lastname: Bültmann
authors.forename: K
authors.initials: K
authors.lastname: Rothenberger-Janzen
authors.forename: H
authors.initials: H
authors.lastname: Guyot
authors.forename: J
authors.initials: J
authors.lastname: Janzen
mesh_terms: D000328:Adult; D003893:Desmin / Q000032:analysis; D005260:Female; D005352:Fibromuscular Dysplasia / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006977:Hypertension, Renal / Q000473:pathology* / Q000601:surgery; D007672:Kidney Cortex / Q000098:blood supply / Q000473:pathology; D008875:Middle Aged; D032342:Muscle Cells / Q000473:pathology; D009392:Nephrectomy; D012077:Renal Artery / Q000473:pathology / Q000601:surgery; D012078:Renal Artery Obstruction / Q000473:pathology* / Q000601:surgery
chemical_list: D003893:Desmin