title: Anti-inflammatory agents from Sandoricum koetjape Merr.
abstract: The anti-inflammatory activity of the stem extracts of Sandoricum koetjape was investigated on topical administration using the TPA (tetradecanoylphorbol acetate)-induced mouse ear inflammation model. Bioassay-guided chromatographic fractionation of active fractions led to the isolation 3-oxo-12-oleanen-29-oic acid and katonic acid as the bioactive principles responsible for the anti-inflammatory acitivity. The percentage of inhibition exhibited by 3-oxo-12-oleanen-29-oic acid was almost equivalent to indomethacin.
authors.affiliation: Forest Research Institute Malaysia, Kepong, Kuala Lumpur, Malaysia. rasadah@frim.gov.my
authors.forename: M A
authors.initials: MA
authors.lastname: Rasadah
authors.forename: S
authors.initials: S
authors.lastname: Khozirah
authors.forename: A A
authors.initials: AA
authors.lastname: Aznie
authors.forename: M M
authors.initials: MM
authors.lastname: Nik
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D029582:Meliaceae; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D013755:Tetradecanoylphorbol Acetate
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate