Rheological determinants in patients with Gaucher disease and internal inflammation.
The purpose of this study was to determine whether the inflammatory response in patients with Gaucher disease (GD) is accompanied by enhanced adhesiveness/aggregation of both red and white blood cells. Sixty patients with GD and matched controls were included. The degree of erythrocyte and leukocyte adhesiveness/aggregation was determined by using a simple slide test and image analysis. Patients with GD had significantly elevated concentrations of fibrinogen (328 vs. 262 mg/dl, P < 0.0001) and accelerated erythrocyte sedimentation rates (27 vs. 13 mm/H, P < 0.005). This was accompanied by a significantly enhanced degree of erythrocyte (75 vs. 85, P < 0.0001) and leukocyte (3.5 vs. 1.3, P < 0.002) adhesiveness/aggregation. The low-grade, smoldering, and subclinical internal inflammation in individuals with GD is accompanied by an increased degree of erythrocyte and leukocyte adhesiveness/aggregation. These findings might have rheological consequences in terms of microcirculatory slow flow and tissue hypoxemia.
Zimran
Ari
A
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
Bashkin
Amir
A
Elstein
Deborah
D
Rudensky
Bernard
B
Rotstein
Rivka
R
Rozenblat
Meirav
M
Mardi
Tamar
T
Zeltser
David
D
Deutsch
Varda
V
Shapira
Itzhak
I
Berliner
Shlomo
S
D000328:Adult; D001799:Blood Sedimentation; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000502:physiology; D002449:Cell Aggregation / Q000502:physiology; D003176:Complement C3 / Q000032:analysis; D004903:Erythrocyte Aggregation / Q000502:physiology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005776:Gaucher Disease / Q000097:blood* / Q000276:immunology; D018056:Hemorheology / Q000379:methods; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007249:Inflammation / Q000097:blood; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
D003176:Complement C3; D007136:Immunoglobulins; D005340:Fibrinogen