title: Hemangioendothelioma of the spine.
abstract: A review of the patient files from our institution's oncology department showed that between 1950 and 2000, 11 patients were diagnosed with hemangioendothelioma of the spine, a rare, low-grade malignant vascular tumor. After reevaluation of the diagnoses by orthopaedic oncologists and pathologists, three patients were excluded; therefore eight patients formed the study group. The eight lesions were located in the thoracic (three) or lumbar spine (five, one in each vertebral level). Computed tomography scans revealed expansile lytic process. All lesions involved the vertebral body, but only one was diffuse with spinous process involvement. Treatment included: external beam irradiation alone (one patient), curettage and external beam irradiation (one patient), laminectomy and external beam irradiation (two patients), anterior resection only (two patients), and anterior resection with postoperative external beam irradiation (two patients). Patients without spinal stabilization had chronic low back pain; no patient with spinal stabilization had such pain. One patient who had surgical resection and radiation therapy had a radiation-induced sarcoma develop after 4 years. One patient who was treated with radiation therapy alone had a metastatic lung lesion develop. No other patient had tumor recurrence or progression. Therefore, patients with hemangioendothelioma of the spine may be treated with radiation therapy alone, surgery alone, or a combination thereof. However, because the number of patients in the current series was small, no definitive recommendations regarding treatment may be made. Resection of large lesions and stabilization of vertebral collapse may decrease back pain.
authors.affiliation: Department of Orthopaedic Surgery, Johns Hopkins University/Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224-2780, USA.
authors.forename: Kamran
authors.initials: K
authors.lastname: Aflatoon
authors.forename: Eric
authors.initials: E
authors.lastname: Staals
authors.forename: Franco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bacchini
authors.forename: Davide
authors.initials: D
authors.lastname: Donati
authors.forename: Nicola
authors.initials: N
authors.lastname: Fabbri
authors.forename: Stephan
authors.initials: S
authors.lastname: Boriani
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Frassica
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006390:Hemangioendothelioma / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D013125:Spinal Neoplasms / Q000175:diagnosis / Q000601:surgery; D013904:Thoracic Vertebrae