title: Nicotine replacement therapy-associated syndrome of inappropriate antidiuretic hormone.
abstract: Nicotine has been documented to regulate the release of plasma arginine vasopressin (AVP). The literature is inconclusive about the effects of nicotine replacement therapy on AVP release, although cigarette smoking has been shown to increase the release of AVP. No clinical case reports have documented the possible association between nicotine replacement and hyponatremia through AVP release. We report a case of a 39-year-old man who experienced syndrome of inappropriate antidiuretic hormone while on nicotine patch therapy. We theorize that the constant serum concentration of nicotine levels provided through the patch may cause hyponatremia through the continuous stimulation of vasopressin.
authors.affiliation: Harrison School of Pharmacy, Auburn University, USA. finchc@methodisthealth.org
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Finch
authors.forename: Miranda R
authors.initials: MR
authors.lastname: Andrus
authors.forename: William A
authors.initials: WA
authors.lastname: Curry
mesh_terms: D000328:Adult; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D008297:Male; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects*; D012907:Smoking / Q000503:physiopathology; D012964:Sodium / Q000097:blood
chemical_list: D009538:Nicotine; D012964:Sodium