The effect of short course high dose methylprednisolon therapy on fibrinogen level in children with acute lymphoblastic leukemia. A preliminary study.
In order to investigate the effects of short term high dose methylprednisolone (HDMP) on fibrinolytic system in patients with ALL, 16 of newly diagnosed 32 ALL patients were given HDMP alone (20 mg/kg per day) for 5 days and the rest 16 patients received conventional dose methylprednisolone (CDMP, 2 mg/kg per day) prior to a combination chemotherapy consisting of methylprednisolone, vincristin, daunorubicin and 9 doses of l-Asparaginase. Fibrinogen levels decreased in both groups at day 5 which was statistically significant in the HDMP group. Baseline d-dimer levels of both groups were significantly higher than those of the control group including 24 healthy children. d-dimer levels significantly decreased after initiation of combination therapy in both groups. There was a significant rise in PAI-1 levels after combination therapy both in HDMP and CDMP groups.
Toksöz
Hayri
H
Department of Pediatric Hematology, Hacettepe University, Ihsan Dog?ramaci Children's Hospital, 06100, Ankara, Turkey.
Unal
Selma
S
Kirazli
Serafettin
S
Gürgey
Aytemiz
A
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007223:Infant; D008775:Methylprednisolone / Q000627:therapeutic use*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000188:drug therapy*
D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D005340:Fibrinogen; D008775:Methylprednisolone