[Fragile histidine triad expression in rhabdomyosarcoma].
OBJECTIVE
To study the expression of fragile histidine triad (FHIT) protein in rhabdomyosarcoma(RMS) and the possible mechanisms of its effect on tumor.


METHODS
Immunohistochemical technique(SP) was used to detect the expression of FHIT in 44 cases of RMS and 20 cases of normal skeletal muscles.


RESULTS
Reduced expression of FHIT was 68.2% (30/44) in the cases of RMS, and was 35% (7/20) in the cases of normal skeletal muscles; a significant difference was seen between the two groups(P < 0.05). There was no significant relationship of the expression of FHIT with the sex of the patient and the histological type and grade of the tumor(P > 0.05). However, a significant relationship was observed between the expression of FHIT and the prognosis of the tumor in respect to relapse and metastasis of tumor(P < 0.05).


CONCLUSIONS
The reduced expression of FHIT may play an important role in the development and progression of rhabdomyosarcoma, and thus may become a new prognostic marker in RMS.
Wang
Shou-li
SL
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Yang
Guang-hua
GH
Bu
Hong
H
Guo
Li-xin
LX
Zhou
Qiao
Q
Zhang
Hong-ying
HY
Ye
Lu
L
D017766:Acid Anhydride Hydrolases / Q000096:biosynthesis* / Q000235:genetics; D014408:Biomarkers, Tumor; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000378:metabolism; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D000099170:Bis(5'-adenosyl)triphosphatase