title: Inhibitory activity of indolin-2-one derivatives on compound 48/80-induced histamine release from mast cells.
abstract: Four alkaloids, previously identified in Isatis species, were tested for their inhibitory effect on histamine release. Whereas tryptanthrin, indirubin and deoxyvasicinone did not inhibit histamine release, the effect of indolin-2-one exceeded that of the mast cell stabilizing drug disodium chromoglycate.
authors.affiliation: Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
authors.forename: G U
authors.initials: GU
authors.lastname: Rüster
authors.forename: B
authors.initials: B
authors.lastname: Hoffmann
authors.forename: M
authors.initials: M
authors.lastname: Hamburger
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
chemical_list: D007211:Indoles; C456900:indolin-2-one; D003189:p-Methoxy-N-methylphenethylamine