[Study on effect of flavonoids from oil-removed seeds of Hippophae rhamnoides on inducing apoptosis of human hepatoma cell].
OBJECTIVE
To investigate the inhibitory and apoptosis-inducing effects of flavonoids from oil-removed seeds of Hippophae rhamnoides (FSH) on liver cancer cell line BEL-7402.


METHODS
SRB, Wright staining, electron microscope and flow cytometry are used to study the effects of STT on BEL-7402 cell line.


RESULTS
FSH has potent inhibitive effect on BEL-7402 cell line in a concentration-dependent manner. BEL-7402 cells exhibit typical morphological alteration of apoptosis when sub-Gl peak can be seen.


CONCLUSIONS
FSH exerts its inhibitive effect on BEL-7402 cells by inducing apoptosis.
Sun
Bin
B
Life Science School of East China Normal University, Shanghai 200062.
Zhang
Ping
P
Qu
Weijing
W
Zhang
Xiaoling
X
Zhuang
Xiuyuan
X
Yang
Huangjian
H
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D031281:Hippophae / Q000737:chemistry; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D005419:Flavonoids