Recent developments in the pathophysiology of cholestasis.
The past decade has brought tremendous growth in the under-standing of the pathophysiologic mechanisms involved in cholestasis, both at the genetic and acquired levels. The discovery and characterization of an array of hepatobiliary transport proteins, the nuclear receptors that regulate them, and the potential clinical implications of these defective, altered, or variably expressed proteins are the key elements of our current understanding of cholestasis. It is hoped that future studies will enhance therapeutic options and the ability to care for patients with cholestatic disorders.
Hutchins
Grant F
GF
Division of Gastroenterology and Hepatology, 982000 University of Nebraska Medical Center, Omaha, NE 68198, USA.
Gollan
John L
JL
D001646:Bile / Q000502:physiology*; D002779:Cholestasis / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D026901:Membrane Transport Proteins / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D026901:Membrane Transport Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors