[New therapeutical options for pulmonary fungal infections in non-neutropenic ICU-patients].
Pulmonary fungal infections in non-neutropenic ICU-patients are not frequent, however, their incidence is increasing with high morbidity and mortality, leading to prolonged stay in ICU wards and to excessive costs dependent on difficult delayed diagnosis. Candida as well as Aspergillus spp. are most important pathogens, but also species of less frequent genera must be taken into account, such as Fusarium, Scedosporium, Cryptococcus and others. Newly evaluated antimycotic agents, such as voriconazole and caspofungin, apart from fluconazole, are not only new options, but must be regarded as agents of choice in non-neutropenic patients.
Höhl
R
R
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum Nürnberg Nord, Prof.-Ernst-Nathan-Str. 1, D-90419 Nürnberg, Deutschland. hoehl@klinikum-nuernberg.de
D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000077336:Caspofungin; D054714:Echinocandins; D015725:Fluconazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007362:Intensive Care Units; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D009503:Neutropenia / Q000150:complications*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010456:Peptides, Cyclic; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D012307:Risk Factors; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D015725:Fluconazole; D000077336:Caspofungin; D065819:Voriconazole