Beyond perfusion: cerebral vascular reactivity and assessment of microvascular permeability.
Beyond perfusion, several other related methods are under development for a more complete characterization of different aspects of vascular function. This article will be divided into two parts focusing on two emerging imaging-based assays of vascular status: 1) the cerebrovascular reactivity to a vasodilatory stimulus and 2) the microvascular permeability to a blood-borne MR-visible tracer. Taken together, these approaches can be seen to extend our interrogation of vascular functional and structural integrity and to offer promising clinical and experimental applications.
Kassner
Andrea
A
Department of Medical Imaging, University Health Network & University of Toronto, Ontario, Canada. andrea.kassner@utoronto.ca
Roberts
Timothy P L
TP
D002199:Capillary Permeability; D002245:Carbon Dioxide; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D006801:Humans; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood; D012119:Respiration; D014664:Vasodilation / Q000187:drug effects
D003287:Contrast Media; D002245:Carbon Dioxide; D010100:Oxygen