title: Cutaneous intravascular lymphoma following extravascular lymphoma of the lung.
abstract: Intravascular lymphoma (IL) is a rare aggressive disease characterized by exclusive or predominant accumulation of malignant lymphoid cells within the lumina of small arteries, veins and capillaries. We describe a 74-year-old woman with IL presenting in the skin as asymptomatic teleangiectatic plaques on the thighs. The cutaneous neoplasm developed 18 months after an extravascular large B cell lymphoma of the lung and heralded its relapse. No neurologic symptoms were present during the course of the fatal disease. Immunophenotypic and immunogenotypic studies confirmed a unique B cell subtype. This case of IL is unusual for the association with an extravascular B cell lymphoma suggesting a link between the two diseases.
authors.affiliation: Department of Biomedical Science and Human Oncology, Second Dermatologic Clinic, University of Turin, Turin, Italy. ctomasini@molinette.piemonte.it
authors.forename: Carlo
authors.initials: C
authors.lastname: Tomasini
authors.forename: Mauro
authors.initials: M
authors.lastname: Novelli
authors.forename: Renata
authors.initials: R
authors.lastname: Ponti
authors.forename: Mario
authors.initials: M
authors.lastname: Pippione
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Bernengo
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000473:pathology*; D016133:Polymerase Chain Reaction; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D016896:Treatment Outcome
chemical_list: D015703:Antigens, CD