A new role in hemostasis for the adhesion receptor P-selectin.
The adhesion receptor P-selectin has long been known to support leukocyte rolling and emigration at sites of inflammation. Recently, P-selectin was also revealed to be a key molecule in hemostasis and thrombosis, mediating platelet rolling, generating procoagulant microparticles containing active tissue factor and enhancing fibrin deposition. Elevated levels of plasma P-selectin are indicative of thrombotic disorders and predictive of future cardiovascular events. Because the interaction between P-selectin and its receptor P-selectin glycoprotein ligand-1 (PSGL-1) represents an important mechanism by which P-selectin induces the formation of procoagulant microparticles and recruits the microparticles to thrombi, anti-thrombotic strategies are currently aimed at inhibiting this interaction. Recent developments also suggest that the procoagulant potential of P-selectin could be used to treat coagulation disorders such as hemophilia A.
Cambien
Beatrice
B
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Wagner
Denisa D
DD
D000818:Animals; D001778:Blood Coagulation Disorders / Q000473:pathology / Q000628:therapy; D002318:Cardiovascular Diseases / Q000473:pathology; D002448:Cell Adhesion; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D019007:P-Selectin / Q000378:metabolism / Q000502:physiology*; D010641:Phenotype; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013925:Thromboplastin / Q000378:metabolism; D013927:Thrombosis / Q000473:pathology
D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein; D005337:Fibrin; D013925:Thromboplastin