[Effects of finasteride on capillary in the ventral prostate of rat].
OBJECTIVE
To investigate the effects of finasteride on capillary in the ventral prostate of rat and study the mechanisms therein involved,


METHODS
Male SD rats were given via gavage finasteride 40 mg/kg per day for 7 days (group B) and for 14 days (group C). The changes of capillary infused with Chinese ink were observed with the use of HE staining. Immunohistochemical (IHC) SP-method was adopted in measuring the protein expression of VEGF and eNOS in rat prostatic tissue.


RESULTS
In comparison with the relevant values measured in the control group (group A), the microvessel density (MVD) values in group B and group C decreased by 35.2% and 56% respectively, the protein expression of VEGF in group B and group C decreased by 31.7% and 62.6% respectively, the protein expression of eNOS in group B and group C decreased by 15.7% and 52.5% respectively.


CONCLUSIONS
Finasteride can inhibit the protein expression of VEGF and eNOS and thereby can suppress angiogenesis of capillary in the ventral prostate of rat.
Liu
Xiao-dong
XD
Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Hong
H
Bu
Hong
H
Lu
Yi-ping
YP
Wei
Qiang
Q
Shi
Ming
M
Chen
Zong-fu
ZF
Yang
Yu-ru
YR
D000818:Animals; D002196:Capillaries / Q000187:drug effects / Q000378:metabolism; D018120:Finasteride / Q000494:pharmacology*; D008297:Male; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D011467:Prostate / Q000098:blood supply*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; D018120:Finasteride; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat