title: Large cell neuroendocrine carcinoma of the uterine corpus metastatic to brain and lung: case report and review of the literature.
abstract: Neuroendocrine carcinoma of the uterine corpus is a rare aggressive tumor with a similar unfavorable outcome to that of the cervix. The large cell type is considerably rarer than the small cell neuroendocrine carcinoma of the uterine corpus. We report a case of a 52-year-old woman who presented with a large cell neuroendocrine tumor of the uterine corpus with very aggressive clinical behavior, cerebral and pulmonary metastases six and four months after initial diagnosis and adjuvant radiotherapy, respectively. Despite successful surgical extirpation of the cerebral metastatic lesion she did not respond to chemotherapy and died four months after disease recurrence.
authors.affiliation: Department of Pathology, Ege University, Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Erhan
authors.forename: Y
authors.initials: Y
authors.lastname: Dikmen
authors.forename: M S
authors.initials: MS
authors.lastname: Yucebilgin
authors.forename: O
authors.initials: O
authors.lastname: Zekioglu
authors.forename: L
authors.initials: L
authors.lastname: Mgoyi
authors.forename: M C
authors.initials: MC
authors.lastname: Terek
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy