Resveratrol derivatives and their role as potassium channels modulators.
A series of stilbenoid analogues of resveratrol (trans-3,4',5-trihydroxystilbene) with a stilbenic or a bibenzylic skeleton have been prepared by partial synthesis from resveratrol and dihydroresveratrol. The synthesized compounds have been evaluated for their ability to modulate voltage-gated channels.
Orsini
F
F
Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, Via Venezian 21, Milano, Italy. fulvia.orsini@unimi.it
Verotta
L
L
Lecchi
M
M
Restano
R
R
Curia
G
G
Redaelli
E
E
Wanke
E
E
D000818:Animals; D051379:Mice; D015394:Molecular Structure; D024642:Potassium Channels, Voltage-Gated / Q000187:drug effects*; D051381:Rats; D000077185:Resveratrol; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D024642:Potassium Channels, Voltage-Gated; D013267:Stilbenes; D000077185:Resveratrol