Translational control: a cup half full.
Repression of translation of oskar and nanos mRNAs prior to their posterior localization in the egg and embryo is essential for body patterning in Drosophila. The Cup protein is now found to have an important role in repression of both mRNAs, and apparently does so in a manner similar to the action of the Xenopus Maskin protein.
Macdonald
Paul M
PM
Institute for Cellular and Molecular Biology, Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, Texas 78712-0159, USA. pmacdonald@mail.utexas.edu
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D014176:Protein Biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics
D029721:Drosophila Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; C105238:cup protein, Drosophila; C091675:osk protein, Drosophila; C070574:nos protein, Drosophila