[Relationship between pathological development of phlegm-stasis and expression of actin in vascular smooth muscle cell in atherosclerosis rat model].
OBJECTIVE
To explore the dynamic change of Phlegm-stasis in the rat atherosclerotic model as the time goes on.


METHODS
Adopting high fat forage fed to develop the atherosclerotic model in rats, and the changes of blood lipid, hemorrheology, blood glucose, insulin and vascular smooth muscle cell (VSMC) actin expression were detected by biochemical and immunohistochemical assay at various time points after modeling.


RESULTS
The expression of VSMC actin gradually increased along with the change of model rats' Syndrome from Phlegm to stasis, i.e., the change of parameters, including blood lipid, hemorrheologic parameters, blood glucose, insulin and insulin sensitive indexes along with the aggravation of disease.


CONCLUSIONS
The expression of VSMC actin could be the molecular mechanism for the Syndrome developing from Phlegm to stasis in atherosclerotic rats.
Wang
Dong-sheng
DS
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008. wdsh123@21cn.com
Yuan
Zhao-kai
ZK
Chen
Fang-ping
FP
D000199:Actins / Q000096:biosynthesis*; D000818:Animals; D001161:Arteriosclerosis / Q000150:complications / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications / Q000473:pathology; D008297:Male; D008516:Medicine, Chinese Traditional; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000199:Actins