Coagulopathy in the equine critical care patient.
Disseminated intravascular coagulation (DIC) is a clinicopathologic syndrome resulting from a multitude of underlying causes that manifests itself clinically as hemostatic/fibrinolytic failure. There is much debate on the definition, diagnosis, and treatment of DIC, a situation that is most likely the result of the multifaceted clinical presentation of the syndrome and the fact that patient outcome is often influenced by the underlying disease process. The fact that DIC increases morbidity and mortality in critical care patients is well established, but the exact mechanism of what specifically occurs on a microvascular level is still often argued.
Dallap
Barbara L
BL
Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA. bldallap@vet.upenn.edu
D000818:Animals; D001777:Blood Coagulation; D003422:Critical Care / Q000379:methods*; D019468:Disease Management; D004211:Disseminated Intravascular Coagulation / Q000401:mortality / Q000503:physiopathology / Q000662:veterinary*; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D006734:Horse Diseases / Q000401:mortality / Q000503:physiopathology*; D006736:Horses; D012307:Risk Factors; D016896:Treatment Outcome