Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas.
Stanniocalcin-1 (STC1) is a new polypeptide hormone that has metabolic effects on target cell mitochondria. Recent studies have shown that the STC1 gene is upregulated in primary breast tumors and co-expressed with the estrogen receptor. In this report we have demonstrated the histological co-localization of STC1 and its receptor in invasive and non-invasive human mammary gland ductal carcinomas. Analysis of 58 malignant breast biopsies revealed that STC1 and its receptor co-localized to cancer cells in 91% of cases. The study therefore reveals that in breast carcinomas STC1 signals in an autocrine feedback loop and opens up the possibility that it may be sequestered by neoplastic cells in much the same manner as it is by non-malignant cells. The data further supports the notion that STC1 plays a role in breast cancer and that it may prove to be a novel diagnostic and prognostic marker, and potential therapeutic target.
McCudden
Christopher R
CR
Department of Physiology and Pharmacology, Faculty of Medicine and Dentistry, The University of Western Ontario, London, Ont., Canada N6A 5C1.
Majewski
Agata
A
Chakrabarti
Subrata
S
Wagner
Graham F
GF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019898:Autocrine Communication; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000473:pathology*; D005260:Female; D006023:Glycoproteins / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008024:Ligands; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D011485:Protein Binding; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000032:analysis*
D006023:Glycoproteins; D008024:Ligands; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C486987:stanniocalcin-1 receptor, human; C051795:teleocalcin