title: DCC protein expression in clear cell renal cell carcinoma.
abstract: OBJECTIVE
  To investigate whether the expression of protein from the "deleted in colorectal cancer" (DCC) gene, which predicts a poor outcome for patients with colorectal carcinoma, can also serve as a prognostic factor in renal cell carcinoma (RCC).
  
  
  METHODS
  The expression of DCC was evaluated immunohistochemically in 94 paraffin-embedded tumour samples from patients with stage T1, T2, and T3 clear cell RCC. The mean follow-up was 52.3 months. The endpoints of the study were recurrence of disease and death from disease.
  
  
  RESULTS
  The under-expression of DCC protein was detected in 63% of patients who died from the disease and in 36% with no evidence of disease. DCC protein under-expression was detected in all patients with T1 tumours who died from the disease, in half the T2 tumours and in two-thirds of T3 tumours.
  
  
  CONCLUSIONS
  DCC protein under-expression correlated with more aggressive tumour behaviour and a greater risk of death from RCC. However, a larger cohort of patients should be assessed before drawing definitive conclusions.
authors.affiliation: Department of Urology, Rabin Medical Center-Beilinson Campus, Petah Tikva, Israel. yoramdekel@hotmail.com
authors.forename: Y
authors.initials: Y
authors.lastname: Dekel
authors.forename: V
authors.initials: V
authors.lastname: Kugel
authors.forename: P M
authors.initials: PM
authors.lastname: Livne
authors.forename: R
authors.initials: R
authors.lastname: Gal
authors.forename: R
authors.initials: R
authors.lastname: Koren
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D000075389:DCC Receptor; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011956:Receptors, Cell Surface; D016019:Survival Analysis; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D000075389:DCC Receptor; C501909:DCC protein, human; D011956:Receptors, Cell Surface; D025521:Tumor Suppressor Proteins