Physiological functions of protein kinase B/Akt.
The genetic manipulation of mice has become an essential and elegant method for studying the function of proteins in physiology, and for testing the veracity of information obtained from cell culture experiments. During the past few years, a variety of transgenic and knockout mouse models of PKB (protein kinase B)/Akt have been generated and investigated. In this paper, we focus on the phenotypes of these PKB/Akt overexpression and mutant mice that may help to elucidate the functions exerted by PKB/Akt in mammals.
Yang
Z-Z
ZZ
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Tschopp
O
O
Baudry
A
A
Dümmler
B
B
Hynx
D
D
Hemmings
B A
BA
D000818:Animals; D001921:Brain / Q000473:pathology; D003920:Diabetes Mellitus / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology; D008297:Male; D008321:Mammary Glands, Animal / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008892:Milk / Q000378:metabolism; D009154:Mutation; D009206:Myocardium / Q000378:metabolism; D010641:Phenotype; D011471:Prostatic Neoplasms / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt; D013953:Thymus Neoplasms / Q000473:pathology
D011518:Proto-Oncogene Proteins; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt