title: Trilostane therapy for treatment of pituitary-dependent hyperadrenocorticism in 5 cats.
abstract: Hyperadrenocorticism is a rare syndrome in cats. Current medical therapy is unsatisfactory and prognosis for long-term survival with surgical treatment is guarded. We report on 5 cats treated with the 3-beta hydroxysteroid dehydrogenase inhibitor trilostane. Diagnosis was confirmed in all cats by endocrine testing. Three cats had concurrent diabetes mellitus. Trilostane reduced clinical signs and improved endocrine test results in all cats, but insulin requirements did not change and all continued to have some signs of hypercortisolemia. Two died or were euthanized after 16 and 140 days, whereas 3 were still alive 6, 11, and 20 months after the start of trilostane therapy. Trilostane ameliorates clinical signs of feline hyperadrenocorticism, but more research is needed before it can be recommended for treatment.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, London, UK. reto.neiger@vetmed.uni-giessen.de
authors.forename: Reto
authors.initials: R
authors.lastname: Neiger
authors.forename: Angela L
authors.initials: AL
authors.lastname: Witt
authors.forename: Ann
authors.initials: A
authors.lastname: Noble
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: German
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000308:Adrenocortical Hyperfunction / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D001774:Blood Chemical Analysis / Q000662:veterinary; D002371:Cat Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002415:Cats; D013196:Dihydrotestosterone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D008297:Male; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D004791:Enzyme Inhibitors; D013196:Dihydrotestosterone; D015096:3-Hydroxysteroid Dehydrogenases; C009954:trilostane