title: Capillary electrophoresis and capillary flow injection analysis with electrochemical detection.
abstract: Measurements by capillary flow injection analysis (CFIA) and capillary electrophoresis (CE) in conjunction with electrochemical detection are described. The detection is based on an end-column electrode arrangement. Several novel electrodes, such as a spherical gold electrode and a dual-microdisk electrode, are presented and characterized regarding their analytical utility. In order to improve the selectivity of CFIA, dual-electrode and multiple-pulse detection are studied using couples of cyanometallates or metallocenes. Capillary electrophoretic experiments with amperometric detection are performed using 50 microm i.d. capillaries without any electrical-field decoupler. The practicality and analytical characteristics of this detection strategy are illustrated for the separation of serotonin and some biological precursors and metabolites of neurotransmitter substances.
authors.affiliation: Departamento de Química, Universidade de Coimbra, P-3049, Coimbra, Portugal.
authors.forename: F M
authors.initials: FM
authors.lastname: Matysik
authors.forename: U
authors.initials: U
authors.lastname: Backofen