Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.
Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.
Harman
Fred S
FS
Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. jmp21@psu.edu
Nicol
Christopher J
CJ
Marin
Holly E
HE
Ward
Jerrold M
JM
Gonzalez
Frank J
FJ
Peters
Jeffrey M
JM
D000818:Animals; D001397:Azoxymethane / Q000633:toxicity; D003110:Colonic Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D003111:Colonic Polyps / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D010641:Phenotype; D018160:Receptors, Cytoplasmic and Nuclear / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D001397:Azoxymethane