title: Ketene acetal and spiroacetal constituents of the marine fungus Aigialus parvus BCC 5311.
abstract: Aigialone (1) and aigialospirol (2), two structurally unique compounds, were isolated from the mangrove fungus Aigialus parvus BCC 5311. The structure of the new ketene acetal 1 was elucidated by spectral analysis, and its relative stereochemistry was determined by X-ray crystallography. The stereochemistry of aigialospirol (2), elucidated by NMR spectral analysis, suggested that this compound is possibly derived from hypothemycin (3), a metabolite previously isolated from this same fungus.
authors.affiliation: Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
authors.forename: Pornrapee
authors.initials: P
authors.lastname: Vongvilai
authors.forename: Masahiko
authors.initials: M
authors.lastname: Isaka
authors.forename: Prasat
authors.initials: P
authors.lastname: Kittakoop
authors.forename: Prasert
authors.initials: P
authors.lastname: Srikitikulchai
authors.forename: Palangpon
authors.initials: P
authors.lastname: Kongsaeree
authors.forename: Yodhathai
authors.initials: Y
authors.lastname: Thebtaranonth
mesh_terms: D000080:Acetals / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005030:Ethylenes; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013785:Thailand; D015025:Zearalenone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000080:Acetals; D001572:Benzofurans; D005030:Ethylenes; D007659:Ketones; C484838:aigialone; C484839:aigialospirol; C120440:hypothemycin; D015025:Zearalenone; C008223:ketene