title: Heparin-induced thrombocytopenia and thrombosis syndrome after cardiac surgery.
abstract: A case report of multisystem organ failure and limb loss associated with coronary artery bypass is reported. Heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) occurs in 1% to 2% of patients suffering from thrombocytopenia associated with heparin or heparinoid use, which amounts to less than 1.4% of the cardiac surgical population. It carries a risk of significant comorbidity and mortality. Providers involved in the care of such patients should be well versed in the etiology and potential complications of HITTS, the treatment options, and alternative modalities of anticoagulation available for use.
authors.affiliation: Department of Surgery, Keesler Medical Center, Keesler Air Force Base, Suite 1A132, 301 Fisher Street, MS 30534, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: DuBose
authors.forename: Michael
authors.initials: M
authors.lastname: Sutherland
authors.forename: Michael
authors.initials: M
authors.lastname: Moulton
authors.forename: Bhaktan
authors.initials: B
authors.lastname: Krishnan
authors.forename: Jerry
authors.initials: J
authors.lastname: Cohn
authors.forename: Jerry W
authors.initials: JW
authors.lastname: Pratt
mesh_terms: D000671:Amputation, Surgical; D000925:Anticoagulants / Q000009:adverse effects*; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000601:surgery; D002432:Cecum / Q000098:blood supply; D003082:Colectomy; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D006493:Heparin / Q000009:adverse effects*; D024764:Hirudin Therapy; D006801:Humans; D007081:Ileostomy; D007511:Ischemia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010976:Platelet Count; D012307:Risk Factors; D013577:Syndrome; D013921:Thrombocytopenia / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D000925:Anticoagulants; D006493:Heparin