title: Australian funnel-web spiders: master insecticide chemists.
abstract: Arthropods are the most diverse animal group on the planet. Their ability to inhabit a vast array of ecological niches has inevitably brought them into conflict with humans. Although only a small minority are classified as pest species, they nevertheless destroy about a quarter of the world's annual crop production and transmit an impressive array of pathogens of human and veterinary public health importance. Arthropod pests have been controlled almost exclusively with chemical insecticides since the introduction of DDT in the 1940s. However, the evolution of resistance to many insecticides, coupled with increased awareness of the potential environmental and human and animal health impacts of these chemicals, has stimulated the search for new insecticidal compounds, novel molecular targets, and alternative control methods. Spider venoms are complex chemical cocktails that have evolved to kill or paralyze arthropod prey, and they represent a largely untapped reservoir of insecticidal compounds. This review focuses on several families of invertebrate-specific peptide neurotoxins that were isolated from the venom of Australian funnel-web spiders. These peptides are promising insecticide leads because of their selectivity for invertebrates and activity on previously unvalidated targets. These toxins should facilitate the development of novel target-based screens for new insecticide leads, while their mapped pharmacophores will provide templates for rational design of mimetics that act at these target sites. Furthermore, genes encoding these toxins can be used to improve the efficacy of insect-specific viruses.
authors.affiliation: Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06032-3305, USA.
authors.forename: Hugo W
authors.initials: HW
authors.lastname: Tedford
authors.forename: Brianna L
authors.initials: BL
authors.lastname: Sollod
authors.forename: Francesco
authors.initials: F
authors.lastname: Maggio
authors.forename: Glenn F
authors.initials: GF
authors.lastname: King
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001315:Australia; D019143:Evolution, Molecular; D007306:Insecticides / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry / Q000633:toxicity*; D010455:Peptides; D010571:Pest Control; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology; D013111:Spider Venoms / Q000737:chemistry*; D013112:Spiders / Q000737:chemistry*
chemical_list: D007306:Insecticides; D009498:Neurotoxins; D010455:Peptides; D013111:Spider Venoms