DNA microarray technology in nutraceutical and food safety.
The quality and quantity of diet is a key determinant of health and disease. Molecular diagnostics may play a key role in food safety related to genetically modified foods, food-borne pathogens and novel nutraceuticals. Functional outcomes in biology are determined, for the most part, by net balance between sets of genes related to the specific outcome in question. The DNA microarray technology offers a new dimension of strength in molecular diagnostics by permitting the simultaneous analysis of large sets of genes. Automation of assay and novel bioinformatics tools make DNA microarrays a robust technology for diagnostics. Since its development a few years ago, this technology has been used for the applications of toxicogenomics, pharmacogenomics, cell biology, and clinical investigations addressing the prevention and intervention of diseases. Optimization of this technology to specifically address food safety is a vast resource that remains to be mined. Efforts to develop diagnostic custom arrays and simplified bioinformatics tools for field use are warranted.
Liu-Stratton
Yiwen
Y
Laboratory of Molecular Medicine and DNA Microarray & Genetics Facility, Department of Surgery, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 W. 12th Avenue, Columbus, OH 43210, USA.
Roy
Sashwati
S
Sen
Chandan K
CK
D000818:Animals; D019587:Dietary Supplements / Q000633:toxicity*; D005502:Food / Q000633:toxicity*; D005516:Food Microbiology; D030841:Food, Genetically Modified / Q000009:adverse effects; D015870:Gene Expression / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D016678:Genome; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis