Effects of intraaortic balloon augmentation in a porcine model of endotoxemic shock.
OBJECTIVE
Patients with septic shock commonly have myocardial dysfunction associated with lactic acid production and troponin I release. The purpose of this study was to evaluate the effects on intraaortic balloon pump (IABP) support on myocardial dysfunction.


METHODS
Prospective, randomized controlled study.


METHODS
Animal research laboratory.


METHODS
Ten pigs had arterial, pulmonary arterial, and coronary catheters inserted. After receiving endotoxin infusion over 30 min, half the animals received IABP support.


RESULTS
Coronary sinus lactic acid levels (P< 0.05 for both 90 min versus baseline and 60 min versus baseline) and arterial lactic acid levels (P < 0.05 for both 90 min versus baseline and 60 min versus baseline) increased with time but did not differ between IABP and sham groups. While overall there was no difference with time in myocardial lactic acid consumption or production (calculated as arterial lactic acid level minus coronary sinus lactic acid level), the IABP group showed net myocardial lactic acid consumption at 90 min, while the sham group showed myocardial lactic acid production. Three of five animals in each group showed troponin I release. The levels were similar and did not differ between groups.


CONCLUSIONS
IABP had no benefits in this porcine model of endotoxemic shock.
Engoren
Milo
M
Department of Anesthesiology, St. Vincent Mercy Medical Center, Toledo, OH 43608, USA. engoren@pol.net
Habib
Robert H
RH
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007423:Intra-Aortic Balloon Pumping; D019344:Lactic Acid / Q000097:blood; D008297:Male; D011446:Prospective Studies; D011897:Random Allocation; D012772:Shock, Septic / Q000628:therapy*; D013552:Swine; D019210:Troponin I
D019210:Troponin I; D019344:Lactic Acid