Synthesis and evaluation of lasonolide A analogues.
Homolasonolide A and 10-desmethyllasonolide A are biologically less active than lasonolide A. The ethyl ester analogue of lasonolide A exhibited higher activity than the parent compound in some biological test.
Joo
Jung Min
JM
School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-747, South Korea.
Kwak
Hyo Shin
HS
Park
Jin Hyun
JH
Song
Ho Young
HY
Lee
Eun
E
D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
C492884:10-desmethyllasonolide A; D018942:Macrolides; C492883:homolasonolide A; C450700:lasonolide A