First-choice antibiotics at subinhibitory concentrations induce persistence of Chlamydia pneumoniae.
Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.
Gieffers
Jens
J
Institute of Medical Microbiology and Hygiene, University of Lübeck, 23538 Luebeck, Germany. Jens.Gieffer@hygiene.ukl.mu-luebeck.de
Rupp
Jan
J
Gebert
Andreas
A
Solbach
Werner
W
Klinger
Matthias
M
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006367:HeLa Cells; D006801:Humans; D008854:Microscopy, Electron
D000900:Anti-Bacterial Agents