title: Prevalence of Helicobacter pylori antibodies in long-term dialysis patients.
abstract: BACKGROUND
  Helicobacter pylori has been reported to play an important role in the development of gastritis and gastric ulcer.
  
  
  METHODS
  This study included 168 patients with end-stage renal disease (ESRD; 30 non-dialysis patients, 138 patients receiving dialysis; mean duration of dialysis: 57.3 +/- 61.7 months) and 138 control volunteers. We investigated the prevalence of H. pylori infection by measuring H. pylori antibody (IgG) levels.
  
  
  RESULTS
  The prevalence of H. pylori infection was 62.3% in the control group, 53.3% in the non-dialysis patients, and 36.9% in the dialysis patients. The percentage decreased with a reduction of renal function. In addition, the proportion of H. pylori-positive patients decreased with the duration of dialysis, and the antibody titre was also significantly decreased. There was no association between long-term oral administration of H2RA (H2 receptor antagonist) and the incidence of H. pylori infection.
  
  
  CONCLUSIONS
  Among dialysis patients, the proportion of H. pylori-positive patients was low. An aetiological factor other than H2RA agents was suggested. Renal failure or dialysis treatment may influence H. pylori infection.
authors.affiliation: Department of Nephrology, Moriguchi Keijinkai Hospital, Moriguchi, Japan. fumitaka@mti.biglobe.ne.jp
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Nakajima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Oka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kawase
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Shibahara
authors.forename: Toru
authors.initials: T
authors.lastname: Inoue
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Ueda
authors.forename: Yoji
authors.initials: Y
authors.lastname: Katsuoka
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D006635:Histamine H2 Antagonists