title: TIP: protein backtranslation aided by genetic algorithms.
abstract: Several applications require the backtranslation of a protein sequence into a nucleic acid sequence. The degeneracy of the genetic code makes this process ambiguous; moreover, not every translation is equally viable. The usual answer is to mimic the codon usage of the target species; however, this does not capture all the relevant features of the 'genomic styles' from different taxa. The program TIP ' Traducción Inversa de Proteínas') applies genetic algorithms to improve the backtranslation, by minimizing the difference of some coding statistics with respect to their average value in the target.
  
  
  BACKGROUND
  http://www.cmm.uchile.cl/genoma/tip/
authors.affiliation: Centro de Modelamiento Matemático and Departamento de Ingeniería Matemática FCFM, U. de Chile, Casilla 170/3-Correo 3, Santiago, Chile. anmoreir@dim.uchile.cl
authors.forename: Andrés
authors.initials: A
authors.lastname: Moreira
authors.forename: Alejandro
authors.initials: A
authors.lastname: Maass
mesh_terms: D000465:Algorithms; D008957:Models, Genetic; D014176:Protein Biosynthesis / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software
chemical_list: D011506:Proteins