title: Polymyositis and hepatitis concurrent with breast cancer.
abstract: OBJECTIVE
  To present a rare case of breast cancer associated with both inflammatory muscle disease and liver disease as a paraneoplastic syndrome.
  
  
  METHODS
  A woman with breast cancer presented with elevated liver enzymes and progressive proximal muscle weakness. Liver biopsy was consistent with hepatitis and muscle biopsy revealed myositis. The start of corticosteroid therapy was followed by relief of the myopathic symptoms and regression of hepatitis histopathologically.
  
  
  CONCLUSIONS
  A case of polymyositis and hepatitis associated with breast cancer and their flare-up with recurrence of malignancy is presented. In this case, the temporal relation with malignancy following its concurrent remission and relapse suggests a paraneoplastic mechanism.
authors.affiliation: Department of Medical Oncology, Gazi University Medical School, Ankara, Turkey. dyamac@gazi.edu.tr
authors.forename: Deniz
authors.initials: D
authors.lastname: Yamac
authors.forename: Nazan
authors.initials: N
authors.lastname: Gunel
authors.forename: Berna
authors.initials: B
authors.lastname: Goker
authors.forename: Ugur
authors.initials: U
authors.lastname: Coskun
authors.forename: Ozlem
authors.initials: O
authors.lastname: Erdem
authors.forename: Gulen
authors.initials: G
authors.lastname: Akyol
authors.forename: Seren
authors.initials: S
authors.lastname: Ozenirler
mesh_terms: D001344:Autopsy; D001943:Breast Neoplasms / Q000150:complications*; D018270:Carcinoma, Ductal, Breast / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006526:Hepatitis C / Q000175:diagnosis* / Q000201:enzymology; D018937:Hepatitis C Antibodies / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness; D018482:Muscle, Skeletal / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D017285:Polymyositis / Q000473:pathology*; D012367:RNA, Viral / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral