title: [A case of inoperable advanced gallbladder cancer that has maintained stable disease status for a long period with gemcitabine and cisplatin therapy].
abstract: We report a case of inoperable advanced gallbladder cancer that responded to treatment with gemcitabine (GEM) and cisplatin (CDDP) therapy. A 54-year-old woman was diagnosed in a nearby hospital with inoperable advanced gallbladder cancer (T4, N1, H0, P1, M(-): Stage IV b) with direct invasion to the liver. Therefore, chemotherapy was performed by TS-1. Two months later, however, the disease was found to have progressed, and she was referred to our hospital for further therapy. Combined chemotherapy with GEM 1,000 mg/m2 on days 1, 8 and 15 and CDDP 50 mg/m2 on day 1 was performed starting in June 2002. No side effects were observed after the first administration during hospitalization, so the treatment was continued on an outpatient basis. Her serum CEA and CA19-9 levels thereafter gradually decreased, and the disease stabilized for over a year. She has been able to maintain good quality of life without any severe adverse effects.
authors.affiliation: Dept. of Internal Medicine, Higashi Sapporo Hospital.
authors.forename: Norihiro
authors.initials: N
authors.lastname: Takayanagi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Chiba
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sagawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Sumio
authors.initials: S
authors.lastname: Sakamaki
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D005260:Female; D005706:Gallbladder Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D017741:Survivors; D014057:Tomography, X-Ray Computed; D000093542:Gemcitabine
chemical_list: D003841:Deoxycytidine; D002945:Cisplatin; D000093542:Gemcitabine