title: New MCRs: the first 4-component reaction leading to 2,4-disubstituted thiazoles.
abstract: New organic reactions allow chemical transformations which were previously not possible. Therefore, new reactions are important contributions to the progress in the field of organic synthesis. In this series we describe the design, scope, and limitations of newly-discovered multi-component reactions (MCRs). Herein, a first example of a MCR is introduced which allows general access to the class of 2,4-di- and 2,4,5-trisubstituted thiazoles.
authors.affiliation: Morphochem AG, München, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kolb
authors.forename: Barbara
authors.initials: B
authors.lastname: Beck
authors.forename: Michael
authors.initials: M
authors.lastname: Almstetter
authors.forename: Stefan
authors.initials: S
authors.lastname: Heck
authors.forename: Eberhardt
authors.initials: E
authors.lastname: Herdtweck
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D013844:Thiazoles