Novel and simple preparation method of matrix-type composite particles for controlled drug release by mechanical action.
Matrix-type composite particle for controlled drug release can readily be prepared through a totally dry process by simple anaerobic mechanical vibration of mechanoradical-containing ethylcellulose (EC) with theophylline powder due to occurrence of collision-induced radical-radical coupling reaction to form interparticle matrices, as well as the formation of interparticle network when solid-state vinyl monomer was further added.
Kondo
Shin-ichi
S
Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University, Japan.
Sasai
Yasushi
Y
Kosaki
Masato
M
Kuzuya
Masayuki
M
D001993:Bronchodilator Agents / Q000008:administration & dosage; D002482:Cellulose / Q000031:analogs & derivatives*; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D005079:Excipients; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011208:Powders; D013056:Spectrophotometry, Ultraviolet; D013806:Theophylline / Q000008:administration & dosage; D014732:Vibration
D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D011208:Powders; C013517:ethyl cellulose; D002482:Cellulose; D013806:Theophylline