title: Failure in heat-shock protein expression in response to UBB+1 protein in progressive supranuclear palsy in humans.
abstract: UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of proteasome inhibition), we demonstrate that UBB+1 and HSP40/HSP70 immunoreactivity do not co-localize in the pons of patients with PSP. As HSPs are involved in both normal tau and proteasome function, these findings may be relevant to the aetiology of PSP and other tauopathies.
authors.affiliation: Reta Lila Weston Institute of Neurological Studies, University College London, 46 Cleveland Street, London, W1T 4JF, UK. hope.andrew@mayo.edu
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hope
authors.forename: Tammaryn
authors.initials: T
authors.lastname: Lashley
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
authors.forename: Rohan
authors.initials: R
authors.lastname: de Silva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011149:Pons / Q000378:metabolism* / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000378:metabolism* / Q000473:pathology; D025801:Ubiquitin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D006360:Heat-Shock Proteins; C479419:UBB protein, human; D025801:Ubiquitin