title: Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmission.
abstract: Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Derdeyn
authors.forename: Julie M
authors.initials: JM
authors.lastname: Decker
authors.forename: Frederic
authors.initials: F
authors.lastname: Bibollet-Ruche
authors.forename: John L
authors.initials: JL
authors.lastname: Mokili
authors.forename: Mark
authors.initials: M
authors.lastname: Muldoon
authors.forename: Scott A
authors.initials: SA
authors.lastname: Denham
authors.forename: Marintha L
authors.initials: ML
authors.lastname: Heil
authors.forename: Francis
authors.initials: F
authors.lastname: Kasolo
authors.forename: Rosemary
authors.initials: R
authors.lastname: Musonda
authors.forename: Beatrice H
authors.initials: BH
authors.lastname: Hahn
authors.forename: George M
authors.initials: GM
authors.lastname: Shaw
authors.forename: Bette T
authors.initials: BT
authors.lastname: Korber
authors.forename: Susan
authors.initials: S
authors.lastname: Allen
authors.forename: Eric
authors.initials: E
authors.lastname: Hunter
mesh_terms: D016915:AIDS Vaccines; D000595:Amino Acid Sequence; D015331:Cohort Studies; D000939:Epitopes / Q000276:immunology; D005260:Female; D015752:Genes, env; D006031:Glycosylation; D015483:HIV Antibodies / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D020010:Heterosexuality; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D011446:Prospective Studies; D019562:Viral Load; D015024:Zambia
chemical_list: D016915:AIDS Vaccines; D000939:Epitopes; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120