title: Importance of pulmonary artery perfusion in cardiac surgery.
abstract: OBJECTIVE
  To investigate the importance of pulmonary artery perfusion in cardiac surgery.
  
  
  METHODS
  Prospective randomized study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Patients undergoing cardiac surgery.
  
  
  METHODS
  Patients in whom the cross-clamp was applied only to the aorta were defined as group 1 (n = 11) and patients in whom the cross-clamp was applied to both the aorta and pulmonary artery were defined as group 2 (n = 11).
  
  
  RESULTS
  Tissue samples obtained from the lower lobe of the left lung before CPB, 20 minutes after cross-clamping, and 20 minutes after declamping were examined under light and electron microscopes. Electron microscopic examination revealed changes in the blood-air barrier, epithelial cells, pneumocytes, and basal membrane were more prominent in group 2. Changes in the leukocyte, neutrophil, and lymphocyte counts of blood samples obtained from the right atrium and right superior pulmonary vein before CPB and 5, 30, 60, and 90 minutes after the removal of clamp were also investigated. The transpulmonary difference was statistically significant at 5 and 30 minutes after declamping in group 1. In group 2, transpulmonary differences continued to be significant at 5, 30, 60, and 90 minutes after declamping. There was no difference between groups in terms of PaO(2)/F(I)O(2) ratio before CPB (group 1: 342.0 +/- 80.0 mmHg, group 2: 349.0 +/- 67.0 mmHg); however, a statistically significant difference was found between the groups 2 hours after declamping (group 1: 418.0 +/- 87.0 mmHg and group 2: 290.0 +/- 110.0 mmHg; p = 0.007).
  
  
  CONCLUSIONS
  Pulmonary artery perfusion was found to be important in cardiac surgery.
authors.affiliation: Department of Cardiovascular Surgery, Trakya University, Erdine, Turkey. turanege@ttnet.net.tr
authors.forename: Turan
authors.initials: T
authors.lastname: Ege
authors.forename: Gülara
authors.initials: G
authors.lastname: Huseyin
authors.forename: Omer
authors.initials: O
authors.lastname: Yalcin
authors.forename: Melih Hulusi
authors.initials: MH
authors.lastname: Us
authors.forename: Cavidan
authors.initials: C
authors.lastname: Arar
authors.forename: Enver
authors.initials: E
authors.lastname: Duran
mesh_terms: D006348:Cardiac Surgical Procedures / Q000379:methods*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods; D006325:Heart Atria / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes; D008168:Lung / Q000098:blood supply / Q000503:physiopathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000503:physiopathology*; D011652:Pulmonary Circulation / Q000502:physiology*; D011667:Pulmonary Veins / Q000503:physiopathology; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors