title: Three-dimensional ultrasonographic findings of the rare chromosomal abnormality 48, XXY/+18: a case report.
abstract: The 48, XXY/+18 is a very rare aneuploidy syndrome which combines the aberration in both autosome and sex chromosome. The authors report a case diagnosed prenatally by lymphocyte culture from fetal blood samples following cordocentesis, 2-dimensional (2DUS) and 3-dimensional ultrasonography (3DUS). At 33 1/7 weeks gestation in an ultrasound examination by indication large for date; single umbilical artery with absence of the left umbilical artery, polyhydramnios and fetal growth restriction were demonstrated. The fetus presented with microcephaly, prominent occiput, low-set ears, micrognathia, hypertelorism, small mouth, bilateral club hands with overlapping fingers, rocker-bottom feet. Karyotyping from the cordocentesis led to the diagnosis of 48, XXY/+18, which was confirmed by the chromosomal analysis of the umbilical cord blood after the baby was born. This is the first reported case of the very rare aneuploidy syndrome in the literature.
authors.affiliation: Division of Fetal Diagnosis and Therapy, Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Ratana
authors.initials: R
authors.lastname: Komwilaisak
authors.forename: Thawalwong
authors.initials: T
authors.lastname: Ratanasiri
authors.forename: Patcharee
authors.initials: P
authors.lastname: Komwilaisak
authors.forename: Saman
authors.initials: S
authors.lastname: Luengwattanawanit
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D000328:Adult; D002869:Chromosome Aberrations; D002887:Chromosomes, Human, Pair 18; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D035583:Rare Diseases; D012729:Sex Chromosome Aberrations; D013577:Syndrome; D013785:Thailand; D014314:Trisomy; D016216:Ultrasonography, Prenatal