Nramp1 deletion does not confer susceptibility to Rhodococcus equi infection in mice.
Rhodococcus equi is an intracellular bacterium that causes pneumonia in immunocompromised people and foals. The Nramp1 gene influences susceptibility to a variety of intracellular bacteria (including mycobacterial species), but not to Mycobacterium tuberculosis. In this study, we demonstrate that mice functionally deleted of the Nramp1 gene were not more susceptible to infection with virulent R. equi (ATCC 33701) than wild-type mice. Susceptibility of mice to infection with the intracellular bacterium R. equi is more similar to that of M. tuberculosis than to other intracellular bacteria, including other mycobacteria.
Cohen
Noah D
ND
Equine Infectious Disease Laboratory, Department of Large Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4475, USA. ncohen@cvm.tamu.edu
Harrington
Jessica
J
Gros
Philippe
P
Del Castro
Lucero
L
Meyer
Dianna
D
Martens
Ronald J
RJ
D000193:Actinomycetales Infections / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D000818:Animals; D027682:Cation Transport Proteins / Q000172:deficiency / Q000235:genetics* / Q000502:physiology; D015169:Colony Count, Microbial; D017353:Gene Deletion; D006736:Horses; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D016929:Rhodococcus equi / Q000302:isolation & purification / Q000472:pathogenicity*; D014774:Virulence; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1