title: Possible role of Mycobacterium tuberculosis complex in Melkersson-Rosenthal syndrome demonstrated with Gen-Probe amplified Mycobacterium tuberculosis direct test.
abstract: Melkersson-Rosenthal (MRS) syndrome is characterized by a classical triad of recurrent or persistent orofacial swelling, peripheral facial nerve paralysis and lingua plicata. Granulomatous cheilitis (GC) is regarded as a monosymptomatic form of MRS. The exact aetiologies of MRS and GC are unknown. In this study we investigated the possible role of mycobacteria in these two conditions. A ribosomal RNA amplification-based Gen-Probe amplified Mycobacterium tuberculosis direct test was used to investigate the presence of M. tuberculosis complex in paraffin-embedded skin biopsy specimens from five patients with MRS and one patient with GC. Three of the six specimens were shown to be positive using this system; one of the positive specimens also showed positive Ziehl-Neelsen staining. These results suggest a possible mycobacterial aetiology for MRS and GC.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kocaeli University, 41 900 Sopaliçiftligi, Derince, Izmit, Turkey. rebiay@kou.edu.tr
authors.forename: Rebiay
authors.initials: R
authors.lastname: Apaydin
authors.forename: Sevgi
authors.initials: S
authors.lastname: Bahadir
authors.forename: N
authors.initials: N
authors.lastname: Kaklikkaya
authors.forename: Neşe
authors.initials: N
authors.lastname: Kakklikkaya
authors.forename: Nilgün
authors.initials: N
authors.lastname: Bilen
authors.forename: Dilek
authors.initials: D
authors.lastname: Bayramgürler
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D015342:DNA Probes; D004487:Edema / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005784:Gene Amplification; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000382:microbiology* / Q000473:pathology; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000502:physiology*; D012336:RNA, Ribosomal, 16S / Q000032:analysis; D012867:Skin / Q000382:microbiology / Q000473:pathology
chemical_list: D015342:DNA Probes; D012336:RNA, Ribosomal, 16S