The historical link between solid-organ transplantation, immunosuppression, and skin cancer.
BACKGROUND
Skin cancers are more common in organ transplant recipients than in the general population.


OBJECTIVE
The objective of this study was establish the historical link between organ transplantation, immunosuppression, and the development of skin cancer.


METHODS
The pertinent literature in cutaneous oncology and transplantation is reviewed.


RESULTS
There is a historical link between organ transplants, immunosuppression, and the subsequent development of skin cancers.


CONCLUSIONS
Organ transplant recipients have more skin cancer than those in the general population and this is temporally related to their degree of immunosuppression.
Randle
Henry W
HW
Department of Dermatology, Mayo Clinic, Jacksonville, Florida 32224, USA. randle.henry@mayo.edu
D049673:History, 20th Century; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016377:Organ Transplantation / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000209:etiology*
D007166:Immunosuppressive Agents