title: Histological examination of an eye with endogenous Aspergillus endophthalmitis treated with oral voriconazole: a case report.
abstract: OBJECTIVE
  To report the histological findings of an eye with severe Aspergillus endophthalmitis after oral treatment with voriconazole. METHODS. Case report.
  
  
  RESULTS
  Histopathological examination revealed no fungal elements in choroidal or retinal vessels. The hyphae were mainly restricted to the vitreal side of the preretinal inflammatory infiltrate. Since the treatment with voriconazole had not been completed at the time of enucleation, the clinical course with potential further limitation or regression of the lesion remains unsettled.
  
  
  CONCLUSIONS
  Endogenous Aspergillus endophthalmitis is a devastating condition often associated with immunodeficiency. The pathogenesis of this entity implies the primary invasion of choroidal and retinal vessels. The lack of antifungal drugs with high blood-ocular permeability results in an extremely poor visual prognosis. Our histological examination indicates promising activity and ocular penetration of the new antifungal agent voriconazole.
authors.affiliation: Department of Ophthalmology, Johannes Gutenberg-University Hospital, Mainz, Germany.
authors.forename: Shakhsanam E
authors.initials: SE
authors.lastname: Aliyeva
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ullmann
authors.forename: Ulrike B
authors.initials: UB
authors.lastname: Kottler
authors.forename: Martine
authors.initials: M
authors.lastname: Frising
authors.forename: Oliver
authors.initials: O
authors.lastname: Schwenn
mesh_terms: D000284:Administration, Oral; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D015353:Eye Enucleation; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole