Structures of the lectins from Pseudomonas aeruginosa: insight into the molecular basis for host glycan recognition.
The opportunistic human pathogen Psuedomonas aeruginosa produces two lectins in close association with virulence factors: PA-IL adn PA-IIL, which bind to galactose- and fucose/mannose-containing glycoconjugates, respectively. We review here the structural aspects of these lectins relative to their putative roles in host recognition, cell surface adhesion and biofilm formation.
Imberty
Anne
A
CERMAV--CNRS, Grenoble, France. imberty@cermav.cnrs.fr
wimmerová
Michaela
M
Mitchell
Edward P
EP
Gilboa-Garber
Nechama
N
D018829:Adhesins, Bacterial / Q000737:chemistry / Q000276:immunology*; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D037102:Lectins / Q000737:chemistry / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000276:immunology
D018829:Adhesins, Bacterial; D006023:Glycoproteins; D037102:Lectins; D011971:Receptors, Immunologic; C038692:adhesin, Pseudomonas