Influence of tensides on the release of medical agents from hydrophilic gels, part 2: The influence of selected tensides on hydrocortisone release from xerogels.
With the increase of polysorbates 20 and 21 concentration in xerogels, in the presence of 1,2-propylene glycol and PEG 200, hydrocortisone half-release periods from these preparations become longer while the half-release periods for polysorbate 80 and propylene glycol, and polysorbate 21 and PEG 200 are proportionally shortened. The concentration of tensides has no significant impact on the half-release periods of hydrocortisone with polysorbate 81 added to xerogels in the presence of propylene glycol and polysorbate 20 and 80 with PEG 200.
Szcześniak
M
M
Department of Pharmaceutical Technology, Wrocław Medical University, Wrocław, Poland.
Kubis
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AA
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005079:Excipients; D005782:Gels; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000737:chemistry*; D020100:Hydrogels; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D005079:Excipients; D005782:Gels; D020100:Hydrogels; D013501:Surface-Active Agents; D006854:Hydrocortisone