[Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy].
OBJECTIVE
To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation.


METHODS
Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs.


RESULTS
P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases.


CONCLUSIONS
Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.
Kang
Xin-li
XL
Department of Urology, Shengli Hospital, Shandong 257055, China.
Geng
Zhen-hong
ZH
Lu
Xing-xiang
XX
Wei
Chao
C
Wang
Jin-gang
JG
Wang
San-zhong
SZ
Ma
Sen
S
Liu
Hong-xin
HX
Xu
Guo-ying
GY
Zhang
Hua-wei
HW
Wang
Guo-yong
GY
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis; D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D004250:DNA Topoisomerases, Type II / Q000032:analysis; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005982:Glutathione Transferase; D004250:DNA Topoisomerases, Type II