title: [Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia].
abstract: We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Eriko
authors.initials: E
authors.lastname: Nagasawa
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Matsushima
authors.forename: Ilseung
authors.initials: I
authors.lastname: Choi
authors.forename: Yoshimichi
authors.initials: Y
authors.lastname: Tachikawa
authors.forename: Rie
authors.initials: R
authors.lastname: Ohtsuka
authors.forename: Hideki
authors.initials: H
authors.lastname: Ishikura
authors.forename: Junji
authors.initials: J
authors.lastname: Nishimura
authors.forename: Shoichi
authors.initials: S
authors.lastname: Inaba
authors.forename: Hajime
authors.initials: H
authors.lastname: Nawata
authors.forename: Koichiro
authors.initials: K
authors.lastname: Muta
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning / Q000379:methods