Paraneoplastic immunobullous disease with an epidermolysis bullosa acquisita phenotype: two cases demonstrating remission with treatment of gynaecological malignancy.
Two cases of paraneoplastic immunobullous disease occurring in women with gynaecological malignancies are reported. Both cases demonstrated mechanobullous mucocutaneous blistering as is typically seen in epidermolysis bullosa acquisita. Their immunopathology, however, favoured a dermal-binding mucous membrane pemphigoid (MMP) (or possibly bullous pemphigoid) for patient 1 and laminin-5 MMP for patient 2. Both patients showed resolution of blistering within 1 year of treatment of their malignancies; uterine and ovarian carcinoma, respectively. These cases are of interest because of their paraneoplastic nature; as well as overlapping clinicoimmunopathological features. In addition, patient 2 is, as far as we are aware, the first report of ovarian-carcinoma-associated laminin-5 MMP.
Chamberlain
Alexander J
AJ
Department of Dermatology, The Churchill, Oxford Radcliffe Hospitals, Oxford, UK. alex_chamberlain@hotmail.com
Cooper
Susan M
SM
Allen
Jill
J
Dean
Diane
D
Baxter
Kay F
KF
Goodfield
Mark J D
MJ
Wojnarowska
Fenella
F
D000368:Aged; D002277:Carcinoma / Q000150:complications* / Q000601:surgery; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000601:surgery; D015815:Cell Adhesion Molecules / Q000032:analysis; D016107:Epidermolysis Bullosa Acquisita / Q000209:etiology* / Q000628:therapy; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications* / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000628:therapy; D010391:Pemphigoid, Bullous / Q000175:diagnosis; D010641:Phenotype; D012074:Remission Induction; D014594:Uterine Neoplasms / Q000150:complications* / Q000601:surgery; D000097794:Kalinin
D015815:Cell Adhesion Molecules; D000097794:Kalinin