title: Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum.
abstract: The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA. ews1@utah.edu
authors.forename: Eric W
authors.initials: EW
authors.lastname: Schmidt
authors.forename: Carmen
authors.initials: C
authors.lastname: Raventos-Suarez
authors.forename: Marc
authors.initials: M
authors.lastname: Bifano
authors.forename: Ana T
authors.initials: AT
authors.lastname: Menendez
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: D John
authors.initials: DJ
authors.lastname: Faulkner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D001921:Brain / Q000187:drug effects; D002417:Cattle; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D050257:Tubulin Modulators; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; D050257:Tubulin Modulators; C484931:scleritodermin A; D014747:Vinblastine