title: Metoprolol CR/XL improves systolic and diastolic left ventricular function in patients with chronic heart failure.
abstract: OBJECTIVE
  To investigate whether metoprolol controlled release/extended release (CR/XL) once daily would improve diastolic and systolic left ventricular function in patients with chronic heart failure and decreased ejection fraction.
  
  
  METHODS
  In an echocardiographic substudy to the Metoprolol CR/XL Randomized Intervention Trial in Heart Failure (MERIT-HF), 66 patients were examined three times during a 12-month period blinded to treatment group, assessing left ventricular dimensions and ejection fraction, and Doppler mitral inflow parameters, all measured in a core laboratory.
  
  
  RESULTS
  In the metoprolol CR/XL group left ventricular ejection fraction increased from 0.26 to 0.31 (P = 0.009) after a mean observation period of 10.6 months, and deceleration time of the early mitral filling wave (E) increased from 189 to 246 ms (P = 0.0012), time velocity integral of E-wave increased from 8.7 to 11.2 cm (P = 0.018), and the duration of the late mitral filling wave (A) increased from 122 to 145 ms (P = 0.014). No significant changes were seen in the placebo group regarding any of these variables.
  
  
  CONCLUSIONS
  Metoprolol CR/XL once daily in addition to standard therapy improved both diastolic and systolic function in patients with chronic heart failure and decreased ejection fraction.
authors.affiliation: Section of Cardiology, Medical Department, Alesund Hospital, Norway. torstein.hole@helse-sunnmore.no
authors.forename: Torstein
authors.initials: T
authors.lastname: Hole
authors.forename: Gisle
authors.initials: G
authors.lastname: Frøland
authors.forename: Lars
authors.initials: L
authors.lastname: Gullestad
authors.forename: Jon
authors.initials: J
authors.lastname: Offstad
authors.forename: Terje
authors.initials: T
authors.lastname: Skjaerpe
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D009200:Myocardial Contraction / Q000187:drug effects; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol