title: [MRI-assisted thermometry for regional hyperthermia and interstitial laser thermotherapy].
abstract: OBJECTIVE
  To demonstrate the potential of quantitative MRI-assisted thermometry for the treatment of tumor patients with regional hyperthermia (RHT) and interstitial laser thermotherapy (ILTT).
  
  
  METHODS
  Two patients and seven tissue samples were investigated using the T1-relaxation time and the chemical shift of the proton resonance frequency (PRF) as temperature sensitive MRI-parameters at 0.2 and 1.5 T. Thermotherapy was applied using either a dedicated MRI-hyperthermia hybrid system or a temperature controlled laser with 830 nm.
  
  
  RESULTS
  Both patients were treated successfully showing clinical benefit. T1 and PRF are depending on the applied thermotherapy method and on the MR-system suitable for MRI-assisted thermometry. The clinical application based on phantom results is not necessarily adequate.
  
  
  CONCLUSIONS
  Clinical application and phantom experiments of RHT and ILTT show the potential of MRI-assisted thermometry for further improvement of both minimal invasive thermotherapy methods. Further investigations concerning optimization of the MRI-techniques, the influence of perfusion or the determination of threshold values are necessary.
authors.affiliation: Institut für Klinische Radiologie, Klinikum Grosshadern der Ludwig-Maximilians-Universität München. michael.peller@med.uni-muenchen.de
authors.forename: M
authors.initials: M
authors.lastname: Peller
authors.forename: A
authors.initials: A
authors.lastname: Muacevic
authors.forename: H
authors.initials: H
authors.lastname: Reinl
authors.forename: R
authors.initials: R
authors.lastname: Sroka
authors.forename: S
authors.initials: S
authors.lastname: Abdel-Rahman
authors.forename: R
authors.initials: R
authors.lastname: Issels
authors.forename: M F
authors.initials: MF
authors.lastname: Reiser
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000628:therapy; D005240:Feasibility Studies; D005260:Female; D005266:Femoral Neoplasms / Q000628:therapy; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010865:Pilot Projects; D013813:Therapy, Computer-Assisted / Q000379:methods*; D013817:Thermography / Q000379:methods*; D016896:Treatment Outcome