Highly enantioselective addition of phenylacetylene to aldehydes catalyzed by a camphorsulfonamide ligand.
The asymmetric addition of phenylacetylene to aldehydes was carried out by using a camphorsulfonamide titanium complex as a catalyst. The reactions proceeded under mild conditions and gave the products with good yields and high ees. This system is very useful for the synthesis of chiral propargylic alcohol. [reaction: see text]
Xu
Zhaoqing
Z
Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Lanzhou 730000, China.
Chen
Chao
C
Xu
Jiangke
J
Miao
Mingbo
M
Yan
Wenjin
W
Wang
Rui
R
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry*; D000438:Alcohols / Q000138:chemical synthesis; D000447:Aldehydes / Q000737:chemistry*; D002164:Camphor / Q000031:analogs & derivatives* / Q000494:pharmacology; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010293:Pargyline / Q000737:chemistry; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry
D000438:Alcohols; D000447:Aldehydes; D008024:Ligands; D013449:Sulfonamides; C044736:phenylacetylene; D002164:Camphor; D010293:Pargyline; D014025:Titanium; D000114:Acetylene