title: Non-Newtonian blood flow in human right coronary arteries: steady state simulations.
abstract: This study looks at blood flow through four different right coronary arteries, which have been reconstructed from bi-plane angiograms. Five non-Newtonian blood models, as well as the usual Newtonian model of blood viscosity, are used to study the wall shear stress in each of these arteries at a particular point in the cardiac cycle. It was found that in the case of steady flow in a given artery, the pattern of wall shear stress is consistent across all models. The magnitude of wall shear stress, however, is influenced by the model used and correlates with graphs of shear stress versus strain for each model. For mid-range velocities of around 0.2 m s(-1) the models are virtually indistinguishable. Local and global non-Newtonian importance factors are introduced, in an attempt to quantify the types of flows where non-Newtonian behaviour is significant. It is concluded that, while the Newtonian model of blood viscosity is a good approximation in regions of mid-range to high shear, it is advisable to use the Generalised Power Law model (which tends to the Newtonian model in those shear ranges in any case) in order to achieve better approximation of wall shear stress at low shear.
authors.affiliation: School of Science, Griffith University, Kessels Road, Nathan, Qld 4111, Australia.
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Johnston
authors.forename: Peter R
authors.initials: PR
authors.lastname: Johnston
authors.forename: Stuart
authors.initials: S
authors.lastname: Corney
authors.forename: David
authors.initials: D
authors.lastname: Kilpatrick
mesh_terms: D001158:Arteries / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001809:Blood Viscosity; D003198:Computer Simulation; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000502:physiology*; D020342:Finite Element Analysis; D018056:Hemorheology / Q000379:methods*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength