Synthesis and antiviral evaluation of some 3'-fluoro bicyclic nucleoside analogues.
The synthesis of 3'-fluoro analogues of recently discovered highly potent anti-VZV furanopyrimidine deoxynucleosides (BCNAs) is herein reported, for both the alkyl and alkylphenyl series. The compounds are tested against a range of herpes viruses and display poor activity, strongly supporting the notion of the importance of the presence of a 3'-OH for antiviral activity.
McGuigan
Christopher
C
Welsh School of Pharmacy, Cardiff University, Cardiff, UK. mcguigan@cardiff.ac.uk
Carangio
Antonella
A
Snoeck
Robert
R
Andrei
Graciela
G
De Clercq
Erik
E
Balzarini
Jan
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002644:Chickenpox / Q000188:drug therapy*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides