Scrotal ulceration during induction therapy of acute promyelocytic leukemia with ATRA.
All-trans-Retinoic acid (ATRA) has been shown to improve survival in patients with acute promyelocytic leukemia (APML). It is a well-tolerated drug except for the serious side effect of ATRA syndrome. Dryness of the skin, cheilitis, and xerostomia are the common mucocutaneous side effects. Occurrence of scrotal ulceration is very rare. We report a 13-year-old boy who had scrotal ulceration caused by ATRA during the induction therapy of APML.
Pavithran
Keechilat
K
Department of Hematology, Medical College Hospital, Trivandrum, India. drkpavithran@hotmail.com
Arjun
Rajalakshmi
R
Aruna
Raman
R
Thomas
Mathew
M
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005832:Genital Diseases, Male / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000188:drug therapy*; D008297:Male; D012611:Scrotum / Q000473:pathology*; D013256:Steroids / Q000008:administration & dosage; D014212:Tretinoin / Q000008:administration & dosage / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D013256:Steroids; D014212:Tretinoin