Prolonged expression of c-Fos protein in the lateral habenular nucleus of the Japanese monkey (Macaca fuscata) after eye enucleation.
To elucidate the effect of traumatic stress on the lateral habenular nucleus, we investigated the time course of the expression of c-Fos protein in this nucleus of the Japanese monkey (Macaca fuscata) after enucleation of one eye using c-Fos protein immunocytochemistry. c-Fos protein-like immunoreactive neurons were significantly increased; the increase started 1 h after the enucleation and remained high for 3-9 h in the lateral habenular nucleus on both sides. These results suggest that the prolonged expression of c-Fos protein occurred in the lateral habenular nucleus after traumatic stress through multiple transsynaptic activations.
Kazi
Jamil Ahsan
JA
Laboratory for Neuroanatomy, Department of Neurology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Mori
Shiro
S
Kuchiiwa
Satoshi
S
Nakagawa
Shiro
S
D000818:Animals; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000378:metabolism*; D015353:Eye Enucleation / Q000379:methods; D005260:Female; D007839:Functional Laterality; D019262:Habenula / Q000737:chemistry / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D008252:Macaca fascicularis; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D040921:Stress Disorders, Traumatic / Q000378:metabolism; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos