title: Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes.
abstract: The present study with rat striatal and cortical synaptosomes evaluated the effect of dexamethasone (300 microg/kg i.p./day) with and without simultaneous adrenalectomy on the oxidative stress induced by 3-nitropropionic acid (20 mg/kg/day for 4 days). Adrenalectomy enhanced the oxidative stress induced by 3-nitropropionic acid. These changes were prevented by previous and simultaneous administration of dexamethasone. Adrenalectomy alone induced oxidative stress with decreases in succinate dehydrogenase activity. Our results revealed that adrenal glucocorticoids, and especially dexamethasone (synthetic glucocorticoid), have a protective effect against oxidative stress induced by 3-nitropropionic acid in some brain regions of the Wistar rat.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Avda. Menéndez Pidal s/n, 14004 Cordoba, Spain. bb1molop@uco.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Montilla
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Muñoz
authors.forename: Manuel
authors.initials: M
authors.lastname: Salcedo
authors.forename: Montserrat
authors.initials: M
authors.lastname: Feijóo
authors.forename: Juan R
authors.initials: JR
authors.lastname: Muñoz-Castañeda
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Bujalance
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004396:Coloring Agents; D003345:Corticosterone / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D009574:Nitro Compounds; D010078:Oxazines; D018384:Oxidative Stress / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects*; D014966:Xanthenes
chemical_list: D004396:Coloring Agents; D005938:Glucocorticoids; D009574:Nitro Compounds; D010078:Oxazines; D011422:Propionates; D011506:Proteins; D014966:Xanthenes; C005843:resazurin; D003907:Dexamethasone; D013482:Superoxide Dismutase; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid; D003345:Corticosterone