Determination of methyldibromoglutaronitrile in cosmetic products by high-performance liquid chromatography with electrochemical detection. Method validation.
An increased frequency of contact allergy to methyldibromoglutaronitrile (MDBGN), a commonly used preservative in cosmetics and other consumer products, has been reported in recent years. A high-performance liquid chromatography (HPLC) method for the determination of MDBGN in cosmetic products has been validated in the present study. The identification is performed by reductive electrochemical detection of the bromine present in the molecule. The method is suitable for compliance testing of cosmetic products as well as for the research to support clinical and epidemiological studies.
Rastogi
Suresh Chandra
SC
National Environmental Research Institute, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark. scr@dmu.dk
Zachariae
Claus
C
Johansen
Jeanne D
JD
Devantier
Charlotte
C
Menné
Torkil
T
D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000032:analysis*; D003877:Dermatitis, Contact; D004563:Electrochemistry; D006801:Humans; D009570:Nitriles / Q000032:analysis*; D012015:Reference Standards; D015203:Reproducibility of Results; D012915:Soaps / Q000032:analysis
D003358:Cosmetics; D009570:Nitriles; D012915:Soaps; C039411:1,2-dibromo-2,4-dicyanobutane