Unrelated peripheral blood and cord blood hematopoietic stem cell transplants for thalassemia major.
Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment available for thalassemia major. While sibling donors are usually used, unrelated bone marrow transplants have also recently been found to be successful. In this report of two patients, we show that, besides using unrelated bone marrow, peripheral blood stem cell and cord blood transplantations from unrelated donors are viable options. We believe a significant contributory factor in both our cases was the large cell dose used.
Tan
Patrick Huat-Chye
PH
Department of Hematology, Singapore General Hospital, Singapore.
Hwang
William Ying Khee
WY
Goh
Yeow Tee
YT
Tan
Poh Lin
PL
Koh
Liang Piu
LP
Tan
Cheng Hoe
CH
Quah
Thuan Chong
TC
D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000628:therapy*