The effects of maternal mild protein restriction on stroke incidence and blood pressure in stroke-prone spontaneously hypertensive rats (SHRSP).
The effect of maternal protein restriction during pregnancy on the offspring's blood pressure was assessed in stroke-prone spontaneously hypertensive rats (SHRSP) which are genetically predisposed to hypertension and stroke. After the confirmation of pregnancy, the control group was given a 20% casein diet, and the low-protein group was fed a 9% casein diet. After the confirmation of delivery, commercial feed was given to both of the groups. No differences were seen between the control and low-protein offspring in regard to body weight, blood pressure elevation, or life span. One percent saline solution was put in the control and low-protein groups after the age of 11 weeks. Blood pressure increased markedly in the low-protein group, on the blood pressure level in the low-protein group on week 2 after salt loading (242+/-6 mmHg) was significantly higher than that in the control group (223+/-9 mmHg; p<0.05). The survival duration was significantly shorter in the low-protein group (113+/-4 days) than in the control group (135+/-22 days; p<0.05). These results suggest that maternal protein malnutrition in SHRSP exerted a high salt sensitivity and a malignant influence on stroke incidence on offspring.
Otani
Lila
L
Division of Advanced Life Sciences, Graduate School of Agriculture, Kinki University, Nakamachi, Nara, Japan.
Shirasaka
Norifumi
N
Yoshizumi
Hajime
H
Murakami
Tetsuo
T
D000818:Animals; D001724:Birth Weight; D001794:Blood Pressure / Q000502:physiology*; D018753:Diet, Protein-Restricted; D005260:Female; D005333:Fetus / Q000378:metabolism; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D015994:Incidence; D008136:Longevity; D039382:Maternal Nutritional Physiological Phenomena; D011247:Pregnancy; D051381:Rats; D011918:Rats, Inbred SHR; D012307:Risk Factors; D012965:Sodium Chloride / Q000494:pharmacology; D020521:Stroke / Q000453:epidemiology / Q000209:etiology*; D015430:Weight Gain
D012965:Sodium Chloride