title: Comparison of 35% carbon dioxide reactivity between panic disorder and eating disorder.
abstract: Patients with panic disorder (PD) are hyperreactive to carbon dioxide (CO(2)), but the specificity of this characteristic to PD is controversial. Anxiety and phobic symptomatology are common to both panic and eating disorders (ED). To investigate the specificity of CO(2) hyperreactivity to PD, the responses to inhalation of a 35% CO(2) and 65% oxygen (O(2)) gas mixture were assessed. Reactions to 35% CO(2) challenge were compared among three groups of age- and sex-matched subjects: 14 patients with ED, 14 patients with PD, and 14 healthy controls (HC). A double-blind, randomized, crossover design was used. Only patients with PD showed a strong reaction to 35% CO(2), while patients with ED and HC did not react significantly. The results support the specificity of CO(2) hyperreactivity to PD.
authors.affiliation: Department of Neuropsychiatric Sciences, Istituto Scientifico H. San Raffaele, Vita-Salute University, 20 via Stamira d'Ancona, 20127 Milan, Italy. perna.giampaolo@hsr.it
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Perna
authors.forename: Alessia
authors.initials: A
authors.lastname: Casolari
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bussi
authors.forename: Michele
authors.initials: M
authors.lastname: Cucchi
authors.forename: Cinzia
authors.initials: C
authors.lastname: Arancio
authors.forename: Laura
authors.initials: L
authors.lastname: Bellodi
mesh_terms: D000280:Administration, Inhalation; D002245:Carbon Dioxide / Q000008:administration & dosage*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D001068:Feeding and Eating Disorders / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016584:Panic Disorder / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D002245:Carbon Dioxide