title: Genetic variations in humans associated with differences in the course of hepatitis C.
abstract: The outcome of hepatitis C virus (HCV) infection varies among individuals, but the genetic factors involved remain unknown. We conducted a population-based association study in which 238 Japanese individuals positive for anti-HCV antibody were genotyped for 269 single nucleotide polymorphisms (SNPs) in 103 candidate genes that might influence the course of infection. Altogether, 50 SNPs in 32 genes were listed. Genetic polymorphisms in IL4, IL8RB, IL10RA, PRL, ADA, NFKB1, GRAP2, CABIN1, IFNAR2, IFI27, IFI41, TNFRSF1A, ALDOB, AP1B1, SULT2B1, EGF, EGFR, TGFB1, LTBP2, and CD4 were associated with persistent viremia (P < 0.05), whereas those in IL1B, IL1RL1, IL2RB, IL12RB1, IL18R1, STAT5A, GRAP2, CABIN1, IFNAR1, Mx1, BMP8, FGL1, LTBP2, CD34, and CD80 were associated with different serum alanine aminotransferase levels in HCV carriers (P < 0.05). The sorted genes allow us to draw novel hypotheses for future studies of HCV infection to ultimately identify bona fide genes and their variations.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine and Molecular Therapeutics, Yamagata University School of Medicine, 2-2-2 Iida-nishi, Yamagata 990-9585, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Guijin
authors.initials: G
authors.lastname: Ji
authors.forename: Haruhide
authors.initials: H
authors.lastname: Shinzawa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumoto
authors.forename: Etsuko
authors.initials: E
authors.lastname: Hattori
authors.forename: Tohru
authors.initials: T
authors.lastname: Adachi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugahara
authors.forename: Jun-itsu
authors.initials: JI
authors.lastname: Ito
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Saito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Togashi
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishii
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsuura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Inageda
authors.forename: Masaaki
authors.initials: M
authors.lastname: Muramatsu
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005820:Genetic Testing / Q000379:methods*; D014644:Genetic Variation; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D014766:Viremia / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*