title: Germ cells: finding programs of mass repression.
abstract: Transcription is globally silenced in the germline of animals. Recent studies have shown that, in Caenorhabditis elegans, this silencing is initially mediated through direct repression, but in Drosophila, the factors involved include pgc, a non-coding cytoplasmic RNA. Why are these mechanisms so diverse and complex?
authors.affiliation: Section of Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA. keith.blackwell@joslin.harvard.edu
authors.forename: T Keith
authors.initials: TK
authors.lastname: Blackwell
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D003594:Cytoplasmic Granules / Q000235:genetics / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism / Q000502:physiology; D020868:Gene Silencing / Q000502:physiology; D005854:Germ Cells / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D012313:RNA / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; C070574:nos protein, Drosophila; D009687:Nuclear Proteins; C100950:pie-1 protein, C elegans; D020794:Receptor Protein-Tyrosine Kinases; D012313:RNA; D016601:RNA-Binding Proteins; C080148:tor protein, Drosophila; D014157:Transcription Factors