title: Uncommon metastatic site of renal adenocarcinoma: the oral tongue.
abstract: Primary tumours metastasizing to the tongue are very unusual and only anecdotal cases have been reported. An exhaustive literature review covering the period from 1970 onwards disclosed only 22 cases of renal adenocarcinoma metastasizing to the tongue. We report the case of an 87-year-old female patient with oral tongue, lung, liver, thyroid gland, pancreas and renal adenocarcinoma metastases. She had undergone contralateral nephrectomy for clear cell carcinoma 10 years before diagnosis of the metastases. The tongue lesion was surgically removed under local anaesthesia. Tongue metastasis of renal adenocarcinoma is usually a manifestation of widespread disease. The prognosis for patients with lingual metastasis of renal adenocarcinoma is poor, the mean interval from diagnosis of tongue metastasis to death being 5.8 months. In our patient, metastatic involvement of the tongue was detected approximately 5 months before death. Treatment of renal adenocarcinoma metastasis to the tongue is usually palliative and aims to provide patient comfort by means of pain relief and prevention of bleeding and infection. Surgical excision is recommended as the primary treatment, with emphasis on preservation of tongue structure and function. Recent data regarding immunotherapy or immunochemotherapy for metastatic renal adenocarcinoma are encouraging.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Padua, Italy. g_marioni@virgilio.it
authors.forename: Gino
authors.initials: G
authors.lastname: Marioni
authors.forename: Elena
authors.initials: E
authors.lastname: Gaio
authors.forename: Alessandro
authors.initials: A
authors.lastname: Poletti
authors.forename: Fiorenza
authors.initials: F
authors.lastname: Derosas
authors.forename: Alberto
authors.initials: A
authors.lastname: Staffieri
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000556:secondary*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology / Q000556:secondary*