title: Acoustic radiation force impulse imaging of thermally- and chemically-induced lesions in soft tissues: preliminary ex vivo results.
abstract: The ability of acoustic radiation force impulse (ARFI) imaging to visualize thermally- and chemically-induced lesions in soft tissues was investigated. Lesions were induced in freshly excised bovine liver samples. Chemical lesions were induced via the injection of formaldehyde and thermal lesions were created using a radiofrequency (RF) ablation system. Although conventional sonography was unable to visualize induced lesions, ARFI imaging was capable of monitoring lesion size and boundaries. Agreement was observed between lesion size in ARFI images and in results from pathology. The fact that ARFI imaging requires no additional equipment aside from that needed for conventional ultrasonic imaging makes it a promising modality for monitoring lesion development in situations where sonography is already involved as a guiding mechanism, such as in procedures requiring precise catheter placement.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. brian.fahey@duke.edu
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Fahey
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Nightingale
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Stutz
authors.forename: Gregg E
authors.initials: GE
authors.lastname: Trahey
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D002417:Cattle; D004195:Disease Models, Animal; D005557:Formaldehyde; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D014463:Ultrasonography
chemical_list: D005557:Formaldehyde