title: Chemokine RANTES promoter polymorphisms in allergic rhinitis.
abstract: OBJECTIVE
  RANTES is one of the most widely studied of the chemokines linked to allergic diseases. Two polymorphisms of the RANTES promoter region (-403 G/A and -28 C/G) have been found. The authors investigated whether these RANTES promoter polymorphisms were associated with allergic rhinitis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Blood samples for genetic analysis were obtained from 151 individuals with allergic rhinitis and from 278 healthy individuals without atopic disease. Polymerase chain reaction-based assays for detection of the -403 G/A and -28 C/G polymorphisms of the RANTES gene were used for genotyping.
  
  
  RESULTS
  The frequencies of both the RANTES -403A and -28G alleles were significantly higher in patients with allergic rhinitis than in control subjects (P <.05 for both).
  
  
  CONCLUSIONS
  The study results indicated that the -403 and -28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis.
authors.affiliation: Department of Anatomy, Wonkwang Institute of Medical Science, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea.
authors.forename: Jeong Joong
authors.initials: JJ
authors.lastname: Kim
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Lee
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
authors.forename: Yong Shin
authors.initials: YS
authors.lastname: Kim
authors.forename: Soo Cheon
authors.initials: SC
authors.lastname: Chae
authors.forename: Hun Taeg
authors.initials: HT
authors.lastname: Chung
authors.forename: Tae Wook
authors.initials: TW
authors.lastname: Choi
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D039981:Pyroglyphidae / Q000276:immunology; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology; D019914:Taq Polymerase / Q000235:genetics
chemical_list: D018946:Chemokine CCL5; D017931:DNA Primers; D019914:Taq Polymerase