Cardiovascular disease delay in centenarian offspring.
BACKGROUND
Previously, the authors have shown that an important component of the ability to survive to exceptionally old age is family health history. This study assessed the age at onset of age-related diseases in centenarian offspring.


METHODS
The health histories of 177 offspring of centenarians enrolled in the nationwide New England Centenarian Study, and 166 controls were assessed from 1997 to 2000. Controls were the offspring of parents born in the same years as the centenarians but at least one of whom died at average life expectancy. Ages at onset of heart disease, hypertension, diabetes, cancer, osteoporosis, cataracts, glaucoma, macular degeneration, depression, thyroid disease, and stroke were compared in the two groups.


RESULTS
The median ages of onset for coronary heart disease (p <.001), hypertension (p <.001), diabetes (p =.002), and stroke (p =.017) were significantly delayed in the centenarian offspring by 5.0, 2.0, 8.5, and 8.5 years, respectively, compared with the age-matched controls. Adjusted hazard ratios were 0.388 (p =.0004), 0.39 (p <.0001), 0.302 (p =.008), and 0.328 (p =.06). No differences were found in the ages of onset for the other diseases investigated.


CONCLUSIONS
The offspring of centenarians show a marked delay in the age of onset for cardiovascular disease, diabetes, hypertension, and stroke but not for other age-related diseases such as cancer, osteoporosis, and thyroid disease. These results suggest that the children of centenarians may be following in their parents' footsteps, markedly delaying the onset of lethal diseases that commonly affect older persons.
Terry
Dellara F
DF
Geriatrics Section, Department of Medicine, Boston Medical Center, Massachusetts 02118, USA. laterry@bu.edu
Wilcox
Marsha A
MA
McCormick
Maegan A
MA
Perls
Thomas T
TT
D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D006331:Heart Diseases / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008136:Longevity / Q000235:genetics; D008297:Male; D009511:New England / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D016019:Survival Analysis