Nonsense-mediated mRNA decay: from vacuum cleaner to Swiss army knife.
Nonsense-mediated mRNA decay (NMD) downmodulates mRNAs that have in-frame premature termination codons and prevents translation of potentially harmful truncated proteins from aberrant mRNAs. Two new approaches have identified physiological NMD substrates, and suggest that NMD functions as a multipurpose tool in the modulation of gene expression.
Neu-Yilik
Gabriele
G
Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. gaby.neu-yilik@med.uni-heidelberg.de
Gehring
Niels H
NH
Hentze
Matthias W
MW
Kulozik
Andreas E
AE
D000818:Animals; D018389:Codon, Nonsense / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
D018389:Codon, Nonsense; D012333:RNA, Messenger