title: [Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy].
abstract: OBJECTIVE
  To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation.
  
  
  METHODS
  Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs.
  
  
  RESULTS
  P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases.
  
  
  CONCLUSIONS
  Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy.
authors.affiliation: Department of Urology, Shengli Hospital, Shandong 257055, China.
authors.forename: Xin-li
authors.initials: XL
authors.lastname: Kang
authors.forename: Zhen-hong
authors.initials: ZH
authors.lastname: Geng
authors.forename: Xing-xiang
authors.initials: XX
authors.lastname: Lu
authors.forename: Chao
authors.initials: C
authors.lastname: Wei
authors.forename: Jin-gang
authors.initials: JG
authors.lastname: Wang
authors.forename: San-zhong
authors.initials: SZ
authors.lastname: Wang
authors.forename: Sen
authors.initials: S
authors.lastname: Ma
authors.forename: Hong-xin
authors.initials: HX
authors.lastname: Liu
authors.forename: Guo-ying
authors.initials: GY
authors.lastname: Xu
authors.forename: Hua-wei
authors.initials: HW
authors.lastname: Zhang
authors.forename: Guo-yong
authors.initials: GY
authors.lastname: Wang
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis; D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D004250:DNA Topoisomerases, Type II / Q000032:analysis; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005982:Glutathione Transferase; D004250:DNA Topoisomerases, Type II