Potential anabolic effects of androgens on bone.
Sex steroid hormones are essential to normal skeletal growth and maintenance throughout life in both men and women. The importance of estrogens to bone health in women becomes obvious at menopause when estrogen deficiency occurs and results in accelerated bone loss. After menopause, estrogen deficiency results in drastic changes in the androgen-estrogen ratio. Thus, the relative importance of androgens after menopause may increase. Androgens also appear to be important for bone health in pre-menopausal women. Evidence from human, animal, and laboratory studies is leading to a better understanding of the effects of androgens on bone in women.
Kearns
Ann E
AE
Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA. kearns.ann@mayo.edu
Khosla
Sundeep
S
D013734:Androgen-Insensitivity Syndrome / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D000728:Androgens / Q000172:deficiency / Q000502:physiology / Q000627:therapeutic use; D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001842:Bone and Bones / Q000187:drug effects / Q000502:physiology; D002986:Clinical Trials as Topic; D015986:Confounding Factors, Epidemiologic; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015914:Estrogen Replacement Therapy / Q000379:methods; D004967:Estrogens / Q000172:deficiency / Q000502:physiology / Q000627:therapeutic use; D005260:Female; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D008297:Male; D008593:Menopause / Q000187:drug effects / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D017697:Premenopause / Q000187:drug effects / Q000502:physiology; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000502:physiology; D016387:Women's Health
D000728:Androgens; D004967:Estrogens; D012738:Sex Hormone-Binding Globulin