Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography.
Chiral ligand-exchange chromatography has been shown to be effective in the resolution and semipreparative separation of 1-aminoindan-1,5-dicarboxylic acid (AIDA) enantiomers. In functional activity experiments, only (S)-AIDA was a potent and mGluR1 subtype selective antagonist.
Natalini
Benedetto
B
Università degli Studi di Perugia, Dipartimento di Chimica e Tecnologia del Farmaco, Perugia, Italy. natalini@iris.chimfarm.unipg.it
Marinozzi
Maura
M
Bade
Katrin
K
Sardella
Roccaldo
R
Thomsen
Christian
C
Pellicciari
Roberto
R
D000818:Animals; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D000432:Methanol / Q000494:pharmacology; D008956:Models, Chemical; D010649:Phenylalanine / Q000737:chemistry; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
C095756:1-aminoindan-1,5-dicarboxylic acid; D018691:Excitatory Amino Acid Antagonists; D007189:Indans; D008024:Ligands; D018094:Receptors, Metabotropic Glutamate; D010649:Phenylalanine; D000432:Methanol