Breast cancer prognosis in relation to family history of breast and ovarian cancer.
We linked four nationwide Swedish population-based registries to identify first-degree family history of breast and ovarian cancer among breast cancer cases diagnosed between 1991 and 1998 and followed them until death, emigration or end of follow-up in December 1998. The median follow-up was 36 months. Using Cox proportional hazards models, the hazard ratio of death (HR) due to breast cancer was estimated. Women with a family history of breast or ovarian cancer (n=2175, 12.7%) had a nonsignificantly better prognosis than women without any family history, HR 0.86 (95% CI 0.71-1.05); this appeared unrelated to age at diagnosis either in the index case or in relative(s) with breast and/or ovarian cancer. Our study shows that prognostic outlook is not worse among breast cancer patients with family history.
Thalib
L
L
Department of Community Medicine and Behavioural Science (Biostatistics), Faculty of Medicine, Kuwait University, Box 24923, Safat 13110, Kuwait.
Wedrén
S
S
Granath
F
F
Adami
H-O
HO
Rydh
B
B
Magnusson
C
C
Hall
P
P
D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000401:mortality*; D005192:Family Health; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics; D011379:Prognosis; D012042:Registries