title: Synthesis and biological activity of substituted 2,4,6-s-triazines.
abstract: Reaction of 7-hydroxy-4-methyl coumarin with amido/ imido alcohols in ethanol containing concentrated hydrochloric acid afforded 8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-coumarins (1a-f). Interaction of 1a-f with hydrazine hydrate in pyridine resulted in 1-amino-8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolines (2a-f). Treatment of 2 with formaldehyde in ethanol resulted in 1,3,5-tris-(8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)-2,4,6-hexahydro-s-triazines (3a-c). Antiviral activity of compounds 2a-d and 3a, 3b upon Japanese encephalitis virus (JEV) and Herpes simplex virus-1 (HSV-1) was evaluated on vero cells in vitro. 3a-c were also screened for their antihypertensive activity.
authors.affiliation: Chemistry Department, University of Lucknow, Lucknow-226007, India. vkpandey48@yahoo.com
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Pandey
authors.forename: Sarah
authors.initials: S
authors.lastname: Tusi
authors.forename: Zehra
authors.initials: Z
authors.lastname: Tusi
authors.forename: Madhawanand
authors.initials: M
authors.lastname: Joshi
authors.forename: Shashikala
authors.initials: S
authors.lastname: Bajpai
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004664:Encephalitis Virus, Japanese / Q000187:drug effects; D005260:Female; D018259:Herpesvirus 1, Human / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000959:Antihypertensive Agents; D000998:Antiviral Agents; D007202:Indicators and Reagents; D014227:Triazines