title: An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction.
abstract: A facile synthetic approach to 2,5-diketopiperazines 4 by the Ugi four-center three-component reaction using commercially available dipeptides as a bifunctional component, aldehydes, and isocyanides was described.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Korea.
authors.forename: Sangwon
authors.initials: S
authors.lastname: Cho
authors.forename: Gyochang
authors.initials: G
authors.lastname: Keum
authors.forename: Soon Bang
authors.initials: SB
authors.lastname: Kang
authors.forename: So-Yeop
authors.initials: SY
authors.lastname: Han
authors.forename: Youseung
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003486:Cyanides / Q000737:chemistry*; D054659:Diketopiperazines; D004151:Dipeptides / Q000737:chemistry*; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis*
chemical_list: D000447:Aldehydes; D003486:Cyanides; D054659:Diketopiperazines; D004151:Dipeptides; D010879:Piperazines