title: [Histoculture drug response assay guided concurrent chemoradiotherapy for lung metastasis from adrenocortical carcinoma--a case report].
abstract: A 50-year-old woman underwent surgical resection of a left adrenocortical carcinoma in April 2000. Bilateral pulmonary metastases and abdominal lymph node metastasis were detected in June 2001. After radiation therapy for the abdominal lymph node metastasis, a pulmonary metastatic lesion was thoracoscopically resected. The specimen was subjected to histoculture drug response assay (HDRA), and results revealed that this tumor was sensitive for cisplatin. We therefore performed concurrent chemoradiotherapy including cisplatin for the residual pulmonary metastatic lesion; a complete response was then obtained. Standard protocols of chemotherapy are often absent for malignant tumors, such as in this case, with low incidences. HDRA seems useful for chemotherapy agent selection in cases of rare malignant tumors.
authors.affiliation: Dept. of Thoracic and Cardiovascular Surgery, Wakayama Medical University.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshimasu
authors.forename: Shoji
authors.initials: S
authors.lastname: Oura
authors.forename: Issei
authors.initials: I
authors.lastname: Hirai
authors.forename: Yozo
authors.initials: Y
authors.lastname: Kokawa
authors.forename: Munehiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Rie
authors.initials: R
authors.lastname: Sasaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tanino
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Sakurai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inagaki
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kodama
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shinke
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D018268:Adrenocortical Carcinoma / Q000188:drug therapy* / Q000532:radiotherapy* / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D000077143:Docetaxel; D004334:Drug Administration Schedule; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D008939:Mitotane / Q000008:administration & dosage; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D008939:Mitotane; D002945:Cisplatin