Association of lymphocyte sub-populations with clustered features of metabolic syndrome in middle-aged Japanese men.
To examine the relationship between altered cellular immune status and clustered features of the metabolic syndrome, we measured body mass index (BMI), serum concentrations of high-density lipoprotein-cholesterol, triglycerides, fasting plasma glucose, and blood pressure levels as well as differential leukocyte counts and lymphocyte sub-populations among 439 apparently healthy Japanese men aged 35-60 years. The components of the metabolic syndrome were defined based on the following criteria: BMI >/=25.0 kg/m(2), fasting plasma glucose >/=6.11 mmol/l, systolic blood pressure >/=130 mmHg and/or diastolic blood pressure >/=85 mmHg, high-density lipoprotein (HDL)-cholesterol <1.03 mmol/l, and fasting triglyceride >/=1.69 mmol/l. Counts of total leukocyte, total lymphocyte, CD3 + T cell, CD4 + T cell, and CD4 + CD45RO + T cell significantly correlated with the number of components of the metabolic syndrome (0, 1, 2, and 3+) after adjustment for age and smoking status. These findings were more evident among smokers than among non-smokers. The counts of total leukocytes, total lymphocytes and more specifically memory (CD4 + CD45RO + T) cells were elevated with clustered features of the metabolic syndrome in middle-aged men, which suggest the involvement of altered cellular immune status in the pathogenesis of atherosclerosis.
Tanigawa
Takeshi
T
Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki-ken 305-8575, Japan. Tt9178@aol.com
Iso
Hiroyasu
H
Yamagishi
Kazumasa
K
Muraki
Isao
I
Kawamura
Noriyuki
N
Nakata
Akinori
A
Sakurai
Susumu
S
Ohira
Tetsuya
T
Shimamoto
Takashi
T
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001795:Blood Pressure Determination; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood*; D016000:Cluster Analysis; D015331:Cohort Studies; D006801:Humans; D007564:Japan; D018655:Lymphocyte Count; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology*; D008875:Middle Aged; D011336:Probability; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides