title: [Alpha-adducin gene G/W460 polymorphism is associated with intracerebral hemorrhage in Chinese].
abstract: OBJECTIVE
  To explore the association between alpha-adducin (ADD1) G/W460 and intracerebral hemorrhage (ICH) in Chinese.
  
  
  METHODS
  Samples of peripheral blood were collected from 456 patients with ICH diagnosed by CT or MRI from 7 clinical centers in China and 454 age, sex, and geographically matched subjects as controls. The ADD1 G/W460 polymorphism was detected by PCR. Information about prior exposure to various potential risk factors was collected by questionnaire survey.
  
  
  RESULTS
  The distribution of ADD1gene G460W polymorphisms in the ICH patients and controls were in agreement with the Hardy-Weinberg proportion. The prevalence of 460W allele among ICH cases was 82.2%, higher than that in the controls (76.0%, crude odds ratio, 1.46; 95% CI, 1.05 to 2.05). The ADD1 460W allele was still significantly associated with ICH after adjustment for hypertension and other ICH putative risk factors (adjusted odds ratio, 1.38; 95% CI, 1.01 to 1.88).
  
  
  CONCLUSIONS
  Alpha-adducin gene G/W 460 polymorphism is significantly associated with the risk of ICH. This association does not appear to be mediated by established ICH risk factors, specifically hypertension status.
authors.affiliation: Sino-German Lab for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Science, Beijing 100037, China.
authors.forename: Xiang-feng
authors.initials: XF
authors.lastname: Dou
authors.forename: Hong-ye
authors.initials: HY
authors.lastname: Zhang
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Huang
authors.forename: Xiao-ning
authors.initials: XN
authors.lastname: Liu
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Ju
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Dao-wen
authors.initials: DW
authors.lastname: Wang
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Liao
authors.forename: Ai-qun
authors.initials: AQ
authors.lastname: Ma
authors.forename: Zhi-ming
authors.initials: ZM
authors.lastname: Zhu
authors.forename: Bing-rang
authors.initials: BR
authors.lastname: Zhao
authors.forename: Ji-zong
authors.initials: JZ
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Ru-tai
authors.initials: RT
authors.lastname: Hui
mesh_terms: D000328:Adult; D000368:Aged; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; D000099291:Adducins