Plasmalemmal vacuolar-type H+-ATPase in cancer biology.
Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental enzymes in nature. V-ATPases are responsible for the regulation of proton concentration in the intracellular acidic compartments. It has similar structure with the mitochondrial F0F1-ATP synthase (F-ATPase). dagger The V-ATPases are composed of multiple subunits and have various physiological functions, including membrane and organelle protein sorting, neurotransmitter uptake, cellular degradative processes, and cytosolic pH regulation. The V-ATPases have been involved in multidrug resistance. Recently, plasma membrane V-ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis. The current knowledge regarding the structure and function of V-ATPase and its role in cancer biology is discussed.
Sennoune
Souad R
SR
Department of Physiology, Texas Tech University, Health Sciences Center, Lubbock, TX 79430, USA. Souad.Sennoune@ttuhsc.edu
Luo
Defeng
D
Martínez-Zaguilán
Raul
R
D000818:Animals; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology*; D025262:Vacuolar Proton-Translocating ATPases / Q000378:metabolism*
D014408:Biomarkers, Tumor; D025262:Vacuolar Proton-Translocating ATPases