title: Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.
abstract: We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described.
authors.affiliation: Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Saito
authors.forename: Ryo
authors.initials: R
authors.lastname: Takeuchi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kamino
authors.forename: Kouji
authors.initials: K
authors.lastname: Kuramochi
authors.forename: Fumio
authors.initials: F
authors.lastname: Sugawara
authors.forename: Kengo
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D003517:Cyclopentanes / Q000138:chemical synthesis / Q000494:pharmacology*; D004253:DNA Nucleotidylexotransferase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005561:Formates / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007189:Indans / Q000138:chemical synthesis / Q000494:pharmacology*; D007982:Levulinic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship
chemical_list: D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D005561:Formates; D007189:Indans; D007982:Levulinic Acids; D019384:Nucleic Acid Synthesis Inhibitors; C492887:manzamenone A; C492889:plakevulin A; C492888:untenone A; D004253:DNA Nucleotidylexotransferase