Clinical correlates of neurological change in posttraumatic stress disorder: an overview of critical systems.
Knowledge about the biological basis of psychological trauma is changing at an exponential rate. A PsychlNFO search on the search terms "locus coeruleus" and "PTSD" revealed one peer-reviewed journal article between 1982 and 1992 and 51 in the subsequent decade. A similar search revealed zero articles on "hippocampus" and "PTSD" between 1982 and 1992 and 170 in the past decade. As clinicians, it is important to become increasingly familiar with this growing literature to use that knowledge to treat and educate patients. Imagine the relief that can be provided to survivors of trauma if clinicians can tell them that they have a good idea about what causes their symptoms and even clearer ideas about how to treat them.One ancillary but invaluable outcome to this work is the fact that understanding the neurological underpinnings of PTSD will go a long way to establishing a necessary equilibrium in nature and nurture's role in the etiology and maintenance of the disorder. In its early conceptualization, PTSD was thought by many to be an ordinary reaction to an extraordinary event, thus placing responsibility for the disorder firmly in the hands of environmental factors. A subsequent emphasis on vulnerability and resiliency factors in the disorder, however, gave the impression that genetic and potentially hard-wired neurological factors were dominant in the expression of the disorder. Appreciating the balance between nature and nurture in the development of stress disorders like PTSD will allow clinicians and patients alike to appreciate the role of personal responsibility in the process of recovery. A parallel, albeit more mature process, has occurred in the area of schizophrenia in the past four decades. Early conceptualizations of schizophrenia placed a heavy burden on parenting and behavioral factors, leaving the patients angry at their parents and parents with unnecessary guilt. The later dominance of genetic and biological theories in the disorder allayed parents of their guilt, but left both parents and patients wondering what might be done in the face of such an affliction. Modern theories of schizophrenia seem to have achieved an appropriate balance that recognizes biological vulnerabilities, but also emphasizes familial and patient responsibilities in recovery and care. In PTSD, a similar equilibrium needs to be found, and understanding the neurobiology of the disorder will go far in achieving that goal. When it is understood how trauma affects the brain and how treatment produces neurobiological changes that may remediate trauma-related effects, the patient will be in a better position to make choices about what can and cannot be done in the process of recovery. Giving patients this critical internal locus of control will provide therapeutic benefits such as confidence,self-esteem, and hope that are likely to enhance changes that occur with intervention.
Kimble
Matthew
M
Boston University School of Medicine/Veterans Administration Boston Healthcare System, 150 South Huntington Avenue, Psychology 116B-2, Boston, MA 02130, USA. m.kimble@bangor.ac.uk
Kaufman
Milissa
M
D000679:Amygdala / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008125:Locus Coeruleus / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D013216:Reflex, Startle; D012154:Reticular Formation / Q000378:metabolism; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D013788:Thalamus / Q000378:metabolism / Q000503:physiopathology
D009638:Norepinephrine