Molecular evidence of repair and plasticity following spinal cord injury.
Investigations into the genetic basis of neuronal damage following spinal cord injury have thus far been limited to the acute phase after the injury. Using microarray analysis, the present study compared the spinal-cord-injury-induced gene expression changes in adult rats at the epicenter and rostral segments of spinal cord at acute (12 h) and delayed (42 days) time points. We have previously reported that the acute response to spinal cord injury involves alterations in genes responsible for inflammation, cell cycle alteration, and altered receptor function. In contrast, the delayed response includes changes in the expression of HSP27, MAG, MAP-2, IGF-1 and ApoE. The alteration in expression of these genes suggests an ongoing repair process in animals whose functional recovery has reached a plateau.
Resnick
Daniel K
DK
Department of Neurological Surgery, University of Wisconsin, K4/834 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA. Resnick@neurosurg.wisc.edu
Schmitt
Caroline
C
Miranpuri
Gurwattan S
GS
Dhodda
Vinay K
VK
Isaacson
Jason
J
Vemuganti
Raghu
R
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D018992:Myelin-Associated Glycoprotein / Q000235:genetics / Q000378:metabolism; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D051381:Rats; D020318:Rats, Long-Evans; D013119:Spinal Cord Injuries / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors; D014945:Wound Healing / Q000235:genetics / Q000502:physiology*
D001057:Apolipoproteins E; D008869:Microtubule-Associated Proteins; D018992:Myelin-Associated Glycoprotein; D007334:Insulin-Like Growth Factor I