Enzyme catalyzed synthesis of some vinyl drug esters in organic medium.
A series of vinyl drug esters was synthesized using acyclovir and chloramphenicol with different carbon chain length acyl donors by alkaline protease from Bacillus subtilis and Lipozyme respectively, in non-aqueous medium. The corresponding vinyl drug derivatives were confirmed by nuclear magnetic resonance and infrared spectrometry. The influences of different organic solvents, reaction time, temperature, and content of water on synthesis of vinyl chloramphenicol esters were studied.
Lv
De-Shui
DS
Department of Chemistry, Zhejiang University, Hangzhou, PR China.
Xue
Xing-Tao
XT
Wang
Na
N
Wu
Qi
Q
Lin
Xian-Fu
XF
D000212:Acyclovir / Q000031:analogs & derivatives / Q000138:chemical synthesis; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D002384:Catalysis; D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000138:chemical synthesis; D004800:Enzymes, Immobilized; D004952:Esters / Q000138:chemical synthesis*; D008049:Lipase; D015394:Molecular Structure; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013379:Substrate Specificity; D013381:Subtilisins; D014753:Vinyl Compounds / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D004800:Enzymes, Immobilized; D004952:Esters; D012997:Solvents; D014753:Vinyl Compounds; D002701:Chloramphenicol; C093666:Lipozyme; D008049:Lipase; D013381:Subtilisins; D000212:Acyclovir