title: Measurement of flow modification in phantom aneurysm model: comparison of coils and a longitudinally and axially asymmetric stent--initial findings.
abstract: Dye-dilution imaging sequences were performed and time-density curves were constructed in elastomer vessel aneurysm models to demonstrate the effectiveness of coils and an asymmetric stent in disrupting standard vortex flow. Compared with the use of coils, the use of stents led to marked flow modification, as seen with imaging sequences, and substantially slower inflow, as indicated by time-density curves, owing to the low-porosity region of the stent that covers the aneurysm orifice. These flow examination results indicate that potentially favorable flow modification features can be created by using the described asymmetric stent design, the use of which may lead to alternative methods of image-guided endovascular cerebral aneurysm therapy.
authors.affiliation: Depts of Radiology, Toshiba Stroke Research Center, State Univ of New York at Buffalo, 3435 Main St, Buffalo, NY 14214, USA. srudin@acsu.buffalo.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Rudin
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wang
authors.forename: Iacovos
authors.initials: I
authors.lastname: Kyprianou
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Hoffmann
authors.forename: Ye
authors.initials: Y
authors.lastname: Wu
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.forename: Lee R
authors.initials: LR
authors.lastname: Guterman
authors.forename: Balazs
authors.initials: B
authors.lastname: Nemes
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Bednarek
authors.forename: Jacek
authors.initials: J
authors.lastname: Dmochowski
authors.forename: L Nelson
authors.initials: LN
authors.lastname: Hopkins
mesh_terms: D019917:Blood Vessel Prosthesis Implantation; D004621:Embolization, Therapeutic / Q000295:instrumentation; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D019047:Phantoms, Imaging; D011673:Pulsatile Flow; D015607:Stents; D013314:Stress, Mechanical; D016896:Treatment Outcome