title: [Advanced urethral carcinoma. Which is the best management of a infrequent disease?].
abstract: Urethral cancer is an uncommon tumor (<0.1% of all genitourinary neoplasms). Most of them are squamous carcinoma, adenocarcinomas are about 5% of all urethral cancer. Surgery is the only curative treatment. Surgical technics depend of tumoral location and extension. Conservative surgery is elective if survival is not compromised. Extensive surgery is needed in large lesions. Chemotherapy (CT) and radiotherapy (RT) must be used in patients in which surgery is not possible. Due to the low incidence of this neoplasm is not well established the best therapeutic approach. We present the case of a female (35 years old) with a diagnosis of urethral adenocarcinoma. The initial stage was IV due to non-regional lymph nodes metastases. Surgery was impossible and the patient received chemotherapy and radiotherapy. The patient achieved complete response with CT but a progression was observed in course of RT. The patient died due to systemic progression.
authors.affiliation: Servicio de Oncología Médica, Hospital La Fe, Valencia.
authors.forename: A
authors.initials: A
authors.lastname: Segura Huerta
authors.forename: J
authors.initials: J
authors.lastname: Molina Saera
authors.forename: L
authors.initials: L
authors.lastname: Palomar Abad
authors.forename: L
authors.initials: L
authors.lastname: Pellín Ariño
authors.forename: A
authors.initials: A
authors.lastname: Guerrero Zotano
authors.forename: V
authors.initials: V
authors.lastname: Calderero Aragón
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy*; D000328:Adult; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D014523:Urethral Neoplasms / Q000473:pathology / Q000628:therapy*