title: Effect of androgen deprivation therapy on bone mineral density in prostate cancer patients.
abstract: OBJECTIVE
  To evaluate the effect of androgen deprivation therapy (ADT) on bone mineral density (BMD) in prostate cancer patients.
  
  
  METHODS
  Forty-nine prostate cancer patients with their BMD determined were divided into two groups: the non-treated group included 21 patients before the commencement of ADT and the treated group, 28 patients, who had received ADT for more than 1 year. BMD was measured by dual energy X-ray absorptiometry (DEXA) in the lumbar spine (L2-4) and femoral neck.
  
  
  RESULTS
  Thirteen (62 %) non-treated and 23 (82 %) treated patients fulfilled the BMD criteria for osteopenia or osteoporosis. Z scores for age-matched control in lumbar spine and femoral neck were -0.9 +/- 0.7 and -0.6 +/- 0.5, respectively, in the treated group, and -1.8 +/- 1.1 and -1.6 +/- 1.0, respectively, in the non-treated group, the differences between the two groups were highly significant (P<0.01).
  
  
  CONCLUSIONS
  Prostate cancer patients who received ADT for more than 1 year had a significantly lower BMD in the lumbar spine and femoral neck than those before the beginning of ADT.
authors.affiliation: Department of Urology, First Municipal People's Hospital, Guangzhou 510180, China.
authors.forename: Jun-Hong
authors.initials: JH
authors.lastname: Deng
authors.forename: Liu-Ping
authors.initials: LP
authors.lastname: Yang
authors.forename: Liang-Sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: De-Fan
authors.initials: DF
authors.lastname: Zhou
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D000728:Androgens / Q000172:deficiency; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology*; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects*; D010024:Osteoporosis / Q000175:diagnosis / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000628:therapy*
chemical_list: D000728:Androgens; D007987:Gonadotropin-Releasing Hormone