Pulmonary hypoplasia and persistent pulmonary hypertension in the newborn with homozygous alpha-thalassemia: a case report and review of the literature.
The survival of infants with homozygous alpha-thalassemia, once considered a lethal diagnosis, is now possible through in utero and postnatal diagnostic and therapeutic interventions. We report the survival of a newborn with homozygous alpha-thalassemia complicated by pulmonary hypoplasia and persistent pulmonary hypertension, an association not previously reported.
Bizzarro
M J
MJ
Department of Pediatrics, Yale-New Haven Hospital, New Haven, Connecticut, USA.
Copel
J A
JA
Pearson
H A
HA
Pober
B
B
Bhandari
V
V
D003937:Diagnosis, Differential; D017707:Erythrocyte Transfusion; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012121:Respiration, Artificial; D017085:alpha-Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000628:therapy