title: WebQTL: web-based complex trait analysis.
abstract: WebQTL is a website that combines databases of complex traits with fast software for mapping quantitative trait loci (QTLs) and for searching for correlations among traits. WebQTL also includes well-curated genotype data for five sets of mouse recombinant inbred (RI) lines. Thus, to identify QTLs, users need provide only quantitative trait data from one of the supported populations. The WebQTL databases include both biological traits--neuroanatomical, pharmacological, and behavioral traits--and microarray-based gene expression data from BXD RI lines. A search function finds correlations between RNA expression and biological traits, and mapping functions find QTLs for either type of trait. The WebQTL service is available at http://www.webqtl.org/.
authors.affiliation: Department of Molecular & Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
authors.forename: Jintao
authors.initials: J
authors.lastname: Wang
authors.forename: Robert W
authors.initials: RW
authors.lastname: Williams
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Manly
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D019295:Computational Biology; D039301:Computers, Molecular; D016208:Databases, Factual; D015870:Gene Expression; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D009488:Neurosciences; D020411:Oligonucleotide Array Sequence Analysis; D009862:Online Systems; D010641:Phenotype; D040641:Quantitative Trait Loci; D011995:Recombination, Genetic