title: Linguistic and cognitive functioning and autism symptoms in young children with fragile X syndrome.
abstract: Linguistic and cognitive profiles were examined in 18 children with autism and 18 children with fragile X syndrome (mean ages = 34 months). State-of-the-art diagnostic procedures for autism symptom identification were administered. Eight children with fragile X met criteria for autism. Comparison of linguistic and cognitive profiles (autism, fragile X without autism, fragile X with autism) revealed that children with fragile X (with autism) were more impaired in nonverbal cognition and expressive language. Receptive language was a relative strength for children with fragile X (without autism). There were no differences in receptive language in children with autism, regardless of fragile X status. Low receptive language may be a marker for autism symptoms in young children with fragile X.
authors.affiliation: Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262, USA. Amy.Philofsky@uchsc.edu
authors.forename: Amy
authors.initials: A
authors.lastname: Philofsky
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hepburn
authors.forename: Athena
authors.initials: A
authors.lastname: Hayes
authors.forename: Randi
authors.initials: R
authors.lastname: Hagerman
authors.forename: Sally J
authors.initials: SJ
authors.lastname: Rogers
mesh_terms: D001321:Autistic Disorder / Q000453:epidemiology*; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D005600:Fragile X Syndrome / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D007223:Infant; D008037:Linguistics / Q000379:methods; D008297:Male; D009483:Neuropsychological Tests; D015588:Observer Variation; D010641:Phenotype; D011795:Surveys and Questionnaires