The management of oral human papillomavirus with topical cidofovir: a case report.
Cidofovir, a purine nucleotide analog of cytosine, has showed significant promise against a number of DNA viruses. In 1997, the US Food and Drug Administration approved the use of cidofovir intravenously in the treatment of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Recent studies and reports suggest that a topical form of cidofovir may be useful for treating viral cutaneous lesions recalcitrant to traditional treatments. We report the case of a 36-year-old man with human immunodeficiency virus (HIV) and recalcitrant human papillomavirus (HPV) lesions on the gingiva that were successfully treated with cidofovir gel 1%.
DeRossi
Scott S
SS
Department of Oral Medicine, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA. scottsd@pobox.upenn.edu
Laudenbach
Joel
J
D000287:Administration, Topical; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D005782:Gels; D015658:HIV Infections; D006801:Humans; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology
D000998:Antiviral Agents; D005782:Gels; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir