Reduced triclosan susceptibility in methicillin-resistant Staphylococcus epidermidis.
Triclosan MIC determination showed that recent Staphylococcus aureus clinical isolates (n = 100) were highly susceptible to triclosan, with a 50% minimal inhibitory concentration (MIC(50)) of 0.12 microg/ml and a MIC(90) of 0.25 microg/ml. Staphylococcus epidermidis isolates (n = 96) were less susceptible, with a MIC(50) of 0.12 microg/ml and a MIC(90) of 8 microg/ml. Decreased susceptibility to triclosan was more prevalent among methicillin-resistant S. epidermidis than among methicillin-sensitive S. epidermidis isolates.
Schmid
Molly B
MB
Affinium Pharmaceuticals, Inc., Toronto, Ontario M5J 1V6, Canada.
Kaplan
Nachum
N
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects*; D014260:Triclosan / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D014260:Triclosan