Severe traumatic head injury in adults: which patients are at risk of early hyperthermia?
OBJECTIVE
Prevention of secondary insults, such as hyperthermia, is a major goal after traumatic brain injury. The aim of our study was to identify risk factors for early hyperthermia in severe head-injured patients.


METHODS
Retrospective cohort study.


METHODS
A 17-bed multidisciplinary ICU of a 700-bed teaching hospital.


METHODS
A total of 101 adult patients admitted from January 1999 to December 2001 requiring continuous monitoring of intracranial pressure according to international guidelines.


RESULTS
Forty-four patients experienced early hyperthermia (at least one episode of body temperature >38.5 degrees C within the first 2 days). On univariate analysis five variables were associated with early hyperthermia: sex; body temperature; white blood cell count on admission; prophylactic use of acetaminophen; and diabetes insipidus within 2 days. On multivariate analysis, white blood cell count >14.5 x 10(9)/l on admission (odds ratio, 7.1; 95% confidence interval, 2.4-20.5; p=0.001) and a body temperature on admission >36 degrees C (odds ratio, 6.7; 95% confidence interval, 2.3-20.1) were strong risk factors of early hyperthermia. Prophylactic use of acetaminophen was negatively associated with early hyperthermia (odds ratio, 0.1; 95% confidence interval, 0.02-0.4). Patients who experienced early hyperthermia were less prone to have good recovery (GOS=5; p=0.03). More patients with severe or moderate disability (GOS=3 or 4) experienced early hyperthermia ( p=0.01).


CONCLUSIONS
We identified a subgroup of patients at high risk of early hyperthermia, which is common in severe head-injured patients. These results could have clinical implications for prevention of hyperthermia after traumatic brain injury in adults.
Geffroy
Arnaud
A
Department of Anesthesiology and Critical Care, Beaujon Hospital, Université Xavier Bichat Paris 7, Assistance Publique-Hôpitaux de Paris, 100 Bvd Général Leclerc, 92118 Clichy Cedex, France. arnaud.geffroy@bjn.ap-hop-paris.fr
Bronchard
Régis
R
Merckx
Paul
P
Seince
Pierre-François
PF
Faillot
Thierry
T
Albaladejo
Pierre
P
Marty
Jean
J
D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D001831:Body Temperature; D001930:Brain Injuries / Q000145:classification / Q000150:complications* / Q000401:mortality; D005260:Female; D005334:Fever / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015601:Injury Severity Score; D007427:Intracranial Pressure; D007902:Length of Stay; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen