title: Cleavage of some annulated tetrahydropyridines under the action of dimethyl acetylene dicarboxylate in protic solvents. New practical route to substituted pyrroles and indoles.
abstract: Tetrahydropyrrolo[3,2-c]pyridines and tetrahydropyrido[4,3-b]indoles undergo piperidine ring opening under the action of dimethyl acetylene dicarboxylate in alcohols or in aqueous dioxane, providing beta-(alk)oxy-substituted pyrroles (indoles) in moderate to high yields.
authors.affiliation: Organic Chemistry Department, Russian Peoples Friendship University, 6, Miklukho-Maklaya St., Moscow 117198, Russia.
authors.forename: Tatiana N
authors.initials: TN
authors.lastname: Borisova
authors.forename: Leonid G
authors.initials: LG
authors.lastname: Voskressensky
authors.forename: Tatiana A
authors.initials: TA
authors.lastname: Soklakova
authors.forename: Larisa N
authors.initials: LN
authors.lastname: Kulikova
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Varlamov
mesh_terms: D000114:Acetylene / Q000494:pharmacology*; D000438:Alcohols / Q000737:chemistry; D002264:Carboxylic Acids / Q000494:pharmacology*; D004146:Dioxanes / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism*; D011758:Pyrroles / Q000737:chemistry; D012997:Solvents
chemical_list: D000438:Alcohols; D002264:Carboxylic Acids; D004146:Dioxanes; D007211:Indoles; D010880:Piperidines; D011725:Pyridines; D011758:Pyrroles; D012997:Solvents; C032727:piperidine; C025223:1,4-dioxane; D000114:Acetylene