[Microbial polysaccharides of marine origin and their potential in human therapeutics].
Bacterial polysaccharides offer fascinating potential applications for the pharmaceutical industry. Although many known marine bacteria produce exopolysaccharides (EPS), continuation in looking for new polysaccharide-producing micro-organisms is promising. Marine bacteria, isolated from deep-sea hydrothermal vents, have demonstrated their ability to produce in aerobic conditions, unusual EPS. With the aim of discovering biological activities, EPS presenting different structural features were studied. An EPS secreted by Vibrio diabolicus was evaluated on the restoration of bone integrity in experimental model and was demonstrated to be a strong bone-healing material. Another EPS produced by Alteromonas infernus was modified in order to obtain new heparin-like compounds. Unlike the native EPS, the resulting EPS presented anticoagulant properties as heparin. These EPS could provide biochemical entities with suitable functions for obtaining new drugs. They present original structural feature that can be modified to design compounds and improve their specificity.
Colliec-Jouault
S
S
Laboratoire de biotechnologie et molécules marines (DRV/VP/BMM), Ifremer, rue de l'Ile-d'Yeu, BP 21105, 44311 Nantes cedex 3, France. sylvia.colliec.jouault@ifremer.fr
Zanchetta
P
P
Helley
D
D
Ratiskol
J
J
Sinquin
C
C
Fischer
A M
AM
Guezennec
J
J
D020591:Alteromonas / Q000737:chemistry; D000818:Animals; D000925:Anticoagulants / Q000302:isolation & purification / Q000627:therapeutic use; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008386:Marine Biology; D011135:Polysaccharides, Bacterial / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology* / Q000627:therapeutic use; D051381:Rats; D012756:Sheep; D012887:Skull Fractures / Q000188:drug therapy; D014733:Vibrio / Q000737:chemistry; D014871:Water Microbiology; D014945:Wound Healing / Q000187:drug effects
D000925:Anticoagulants; D011135:Polysaccharides, Bacterial