Solvent-drop grinding: green polymorph control of cocrystallisation.
By grinding with a minimal addition of a solvent of appropriate polarity, control over the polymorphic outcome of a novel cocrystallisation involving the model pharmaceutical compound caffeine may be achieved.
Trask
Andrew V
AV
Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Motherwell
W D Samuel
WD
Jones
William
W
D002110:Caffeine / Q000737:chemistry; D003460:Crystallization; D005977:Glutarates / Q000737:chemistry; D015394:Molecular Structure; D019999:Pharmaceutical Solutions / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*; D014961:X-Ray Diffraction
D005977:Glutarates; D019999:Pharmaceutical Solutions; D012997:Solvents; D002110:Caffeine; C035736:glutaric acid