title: [Selection of an extraction agent and development of the technology for producing an extract with sedative effects].
abstract: The drugs Valerinae radix, Crataegi fructus, Leonuri herba and Melissae folium were used to produce a liquid plant extract. The experiment revealed that the extraction with 70% ethanol achieved the highest concentration of extractable active principles. The optimal conditions for obtaining a sedative extract are established when the method of repercolation is used, and in the production itself the batch of the drug is divided into equally large doses and a pre-prepared mixture of plant drugs is extracted. The extract prepared by this manner remains stable for the whole period of storage, i.e., 24 months.
authors.affiliation: Katedra technologie léků a OF Farmaceutické fakulty Kaunasské univerzity medicíny, Kaunas, Litevská republika.
authors.forename: A
authors.initials: A
authors.lastname: Savickas
authors.forename: K
authors.initials: K
authors.lastname: Ramanauskiene
authors.forename: N
authors.initials: N
authors.lastname: Savickiene
authors.forename: S
authors.initials: S
authors.lastname: Kazlauskas
authors.forename: R
authors.initials: R
authors.lastname: Masteiková
authors.forename: Z
authors.initials: Z
authors.lastname: Chalupová
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D006993:Hypnotics and Sedatives / Q000302:isolation & purification*; D010936:Plant Extracts / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D006993:Hypnotics and Sedatives; D010936:Plant Extracts