Hormonal and genetic determinants of bone loss in community-dwelling elderly men: a longitudinal population study.
In community-dwelling elderly men over age 70 years, BioE2 was positively associated with prospectively assessed BMD changes over 4 years. The CYP19 (TTTA)n-repeat polymorphism was, moreover, an additional independent determinant of BMD changes at the distal forearm. Furthermore, the CYP19 genotype was associated with self-reported clinical fracture status. The present analyses add further evidence to the view that serum BioE2 is a determinant of bone mass in elderly men and provides an indication that the aromatase enzyme may exert a direct modulatory action on bone metabolism at the tissue level in ageing men.
Goemaere
S
S
Unit for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185-B 9000 Gent.
van Pottelbergh
I
I
Kaufman
J M
JM
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001141:Aromatase / Q000235:genetics*; D015519:Bone Density / Q000235:genetics*; D001842:Bone and Bones / Q000201:enzymology*; D015331:Cohort Studies; D004958:Estradiol / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010024:Osteoporosis / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic
D004958:Estradiol; D001141:Aromatase