Florid ischemic cholangitis due to leucocytoclastic vasculitis.
Ischemia-induced biliary tract lesions, called ischemic cholangitis, often lead to strictures of biliary ducts and cholestasis. Causes of ischemic changes of the biliary tract can be found in the arterial blood supply or in the peribiliary capillary plexus. Known examples are thrombosis after transplantation, intraoperative ligation, or the application of chemotherapeutic drugs. Rarely, such changes are due to inflammation of the blood vessels, such as occurs in polyarteritis nodosa or giant cell arteritis. We present a report of a 49-year old man with leucocytoclastic vasculitis after viral infection, influenza vaccination, and antibiotic treatment, leading to florid ischemic cholangitis. We conclude that hypersensitivity vasculitis must be included in the differential diagnosis of cholestasis and cholangitis.
Kasper
Hans-Udo
HU
Department of Pathology, University of Cologne, Joseph-Stelzmann-Str. 9, D-50931, Cologne, Germany.
Dries
Volker
V
Drebber
Uta
U
Stippel
Dirk
D
Reinhold
Katharina
K
Dienes
Hans Peter
HP
D002761:Cholangitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications* / Q000209:etiology