title: Cloning and expression of human GTDC1 gene (glycosyltransferase-like domain containing 1) from human fetal library.
abstract: The glycosyltransferases (GTs) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Here we report the cloning and characterization of a novel human GTDC1 (glycosyltransferase-like domain containing 1) gene, which locates on human chromosome 2q22. The GTDC1 cDNA is 2954 bp in length, encoding a putative protein of 458 amino acids. At protein level human GTDC1 has 75 and 37% identity with its homologous counterparts in the mouse and fruitfly, respectively. RT-PCR analysis revealed its relatively high expression level in the adult lung, spleen, testis, and peripheral blood leukocyte.
authors.affiliation: State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200433, PR China.
authors.forename: Enpeng
authors.initials: E
authors.lastname: Zhao
authors.forename: Yao
authors.initials: Y
authors.lastname: Li
authors.forename: Xuping
authors.initials: X
authors.lastname: Fu
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Huawu
authors.initials: H
authors.lastname: Zeng
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Yin
authors.forename: Ji
authors.initials: J
authors.lastname: Qian
authors.forename: Kang
authors.initials: K
authors.lastname: Ying
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.forename: Robert Chunhua
authors.initials: RC
authors.lastname: Zhao
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Mao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D019295:Computational Biology; D016695:Glycosyltransferases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity
chemical_list: C484366:GTDC1 protein, human; D016695:Glycosyltransferases