title: Prokinetics in the treatment of acute intestinal pseudo-obstruction.
abstract: Acute colonic pseudo-obstruction (Ogilvie's syndrome) is characterized by an acute obstruction of the large bowel that is unrelated to mechanical causes. The evidence that cholinesterase inhibitors are effective in relieving acute colonic pseudo-obstruction raised interest in the pharmacological management of this condition. This review analyzes the pharmacological treatment of patients with Ogilvie's syndrome. Intravenous neostigmine is the best pharmacological treatment, leading to rapid colonic decompression. New colokinetic agents, including 5-HT(4) receptor agonists and motilides, may represent other useful therapeutic options for Ogilvie's syndrome.
authors.affiliation: Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna I-40138, Italy. deg@orsola-malpighi.med.unibo.it
authors.forename: Roberto
authors.initials: R
authors.lastname: De Giorgio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Stanghellini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barbara
authors.forename: Stefani
authors.initials: S
authors.lastname: Guerrini
authors.forename: Andrea
authors.initials: A
authors.lastname: Lioce
authors.forename: Valentina
authors.initials: V
authors.lastname: Vasina
authors.forename: Marcello
authors.initials: M
authors.lastname: Tonini
authors.forename: Bruno
authors.initials: B
authors.lastname: Cola
authors.forename: Roberto
authors.initials: R
authors.lastname: Corinaldesi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: De Ponti
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D016145:Endoscopy, Digestive System; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D013268:Stimulation, Chemical
chemical_list: D002800:Cholinesterase Inhibitors; D017366:Serotonin Receptor Agonists