Stereoselective iodine atom transfer [3 + 2] cycloaddition reaction with alkenes using unsymmetrical allylated active methine radicals.
Treatment of 1-diethylphosphonyl- or 1-phenylsulfonyl-2-(iodomethyl)cyclopropane-1-carboxylate with Et(3)B leads to an unsymmetrical allylated active methine radical species that gives functionalized cyclopentane derivatives with high stereoselectivity through iodine atom transfer [3 + 2] cycloaddition reaction with alkenes.
Kitagawa
Osamu
O
Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Miyaji
Shinsaku
S
Sakuma
Chiseko
C
Taguchi
Takeo
T