[Structure and degradation property of the PVA-collagen complex drug membrane].
OBJECTIVE
To investigate the structure and degradation property of the polyvinyl alcohol (PVA)-collagen complex drug membrane.


METHODS
Drug collagen membrane was complexed with PVA. The physical and chemical properties of the membrane were characterized by transmission electron microscopy, scanning electron microscope, forier transform-infrared spectroscopy and differential scanning calorimetry. Degradation experiment was performed to determine the degradation property of membrane and a degradation curve was therefor drawn.


RESULTS
The thermodynamic stability of collagen membrane was not destroyed by adding PVA. Collagen had good compatibility with PVA. Compared with collagen membrane, collagen-PVA complex membrane had smaller and evener pores. Adding PVA decreased the degradation rate of membrane.


CONCLUSIONS
PVA-collagen membrane has better microstructure and antidegradation property than collagen membrane.
Liang
Yi
Y
Biomaterials Lab, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192, China.
Liu
Ling-rong
LR
Zhang
Qi-qing
QQ
D001672:Biocompatible Materials / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry* / Q000648:ultrastructure; D006801:Humans; D008566:Membranes; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
D001672:Biocompatible Materials; D011142:Polyvinyl Alcohol; D003094:Collagen