title: MTH-68/H oncolytic viral treatment in human high-grade gliomas.
abstract: Application of virus therapy to treat human neoplasms has over a three decade history. MTH-68/H, a live attenuated oncolytic viral strain of the Newcastle disease virus, is one of the viruses used in the treatment of different malignancies. Here we report on the administration of MTH-68/H to patients with glioblastoma multiforme, the most common and most aggressive neuroectodermal neoplasm with a poor prognosis, averaging six months to a year. Four cases of advanced high-grade glioma were treated with MTH-68/H after the conventional modalities of anti-neoplastic therapies had failed. This treatment resulted in survival rates of 5-9 years, with each patient still living today. Against all odds, each patient resumed a lifestyle that resembles their previous daily routines and enjoys a good quality of life, Each of these patients has regularly received MTH-68/H as their sole form of onco-therapy for a number of years now without interruption.
authors.affiliation: United Cancer Research Institute, Alexandria, VA 22307, USA. UCRI@aol.com
authors.forename: L K
authors.initials: LK
authors.lastname: Csatary
authors.forename: G
authors.initials: G
authors.lastname: Gosztonyi
authors.forename: J
authors.initials: J
authors.lastname: Szeberenyi
authors.forename: Z
authors.initials: Z
authors.lastname: Fabian
authors.forename: V
authors.initials: V
authors.lastname: Liszka
authors.forename: B
authors.initials: B
authors.lastname: Bodey
authors.forename: C M
authors.initials: CM
authors.lastname: Csatary
mesh_terms: D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002648:Child; D005260:Female; D005910:Glioma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009522:Newcastle disease virus / Q000276:immunology*; D011788:Quality of Life; D014765:Viral Vaccines / Q000627:therapeutic use*
chemical_list: C424862:Newcastle disease virus vaccine MTH-68-H; D014765:Viral Vaccines