title: Elevated erythropoietin in vitreous with ischemic retinal diseases.
abstract: The aim of the current study was to measure the concentrations of erythropoietin in the vitreous fluid and analyze its association with vascular endothelial growth factor (VEGF) in ischemic vitreoretinal diseases. Vitreous fluid samples were collected from patients with proliferative diabetic retinopathy, branch retinal vein occlusion and idiopathic macular hole. Concentrations of erythropoietin and VEGF in vitreous fluid were significantly elevated in patients with proliferative diabetic retinopathy and branch retinal vein occlusion as compared to patients with macular hole. There were no differences in serum concentrations of erythropoietin and VEGF among patient groups. There was significant correlation between erythropoietin and VEGF concentrations in vitreous fluid. Erythropoietin was up-regulated in ischemic disorders and may act as an endogenous neuroprotective factor against ischemic retinal disorders.
authors.affiliation: Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
authors.forename: Yasuya
authors.initials: Y
authors.lastname: Inomata
authors.forename: Akira
authors.initials: A
authors.lastname: Hirata
authors.forename: Eri
authors.initials: E
authors.lastname: Takahashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kawaji
authors.forename: Mikiko
authors.initials: M
authors.lastname: Fukushima
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Tanihara
mesh_terms: D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D004921:Erythropoietin / Q000032:analysis / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000378:metabolism*; D012164:Retinal Diseases / Q000097:blood*; D042442:Vascular Endothelial Growth Factors / Q000032:analysis / Q000097:blood; D014822:Vitreous Body / Q000737:chemistry*
chemical_list: D042442:Vascular Endothelial Growth Factors; D004921:Erythropoietin