[Clinical significance of serum S-100B protein in severe cerebral injury].
OBJECTIVE
To investigate the value of S-100B protein as a biology marker in diagnosis and prognostic after severe cerebral injury.


METHODS
Sixty-six patients with severe head injury (Glasgow coma scale score (GCS)<or=8) were included in this study, venous blood samples for S-100B protein were obtained as soon as possible after admission and every 24 hours thereafter for a maximum of 3-7 consecutive days. Serum levels of S-100B protein were compared with outcome (Glasgow outcome scale score, GOS) after 6 months.


RESULTS
Of 66 patients, 25 patients died, mutilation in 22 patients, 19 patients had a good outcome. Patients who died had significantly higher serum S-100B values compared with those who survived (median 2.60 microg/L vs. 0.55 microg/L, P<0.001), 14 of 25 patients who died had peak S-100B values of 2.00 microg/L or higher, compared with 4 of 41 surviving patients (P<0.005).


CONCLUSIONS
S-100B protein has a reliable value in diagnosis and prognostic after severe head injury.
Hu
Dian-lei
DL
Department of Neurosurgery, Xuzhou Third Hospital, Xuzhou 221005, Jiangsu, China.
Liu
Xian-hua
XH
Yu
Xiao-liang
XL
Guo
Hong-mei
HM
Guo
Bing
B
Shi
Yan
Y
Zhuang
Hui-lin
HL
Shi
Peng
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000097:blood* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013997:Time Factors; D015599:Trauma Severity Indices
D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins