title: A hollow-fiber membrane extraction process for recovery and separation of lactic acid from aqueous solution.
abstract: An energy-efficient hollow-fiber membrane extraction process was successfully developed to separate and recover lactic acid produced in fermentation. Although many fermentation processes have been developed for lactic acid production, an economical method for lactic acid recovery from the fermentation broth is still needed. Continuous extraction of lactic acid from a simulated aqueous stream was achieved by using Alamine 336 in 2-octanol contained in a hollow-fiber membrane extractor. In this process, the extractant was simultaneously regenerated by stripping with NaOH in a second membrane extractor, and the final product is a concentrated lactate salt solution. The extraction rate increased linearly with an increase in the Alamine 336 content in the solvent (from 5 to 40%). Increasing the concentration of the undissociated lactic acid in the feed solution by either increasing the lactate concentration (from 5 to 40 g/L) or decreasing the solution pH (from 5.0 to 4.0) also increased the extraction rate. Based on these observations, a reactive extraction model with a first-order reaction mechanism for both lactic acid and amine concentrations was proposed. The extraction rate also increased with an increase in the feed flow rate, but not the flow rates of solvent and the stripping solution, suggesting that the process was not limited by diffusion in the liquid films or membrane pores. A mathematical model considering both diffusion and chemical reaction in the extractor and back extractor was developed to simulate the process. The model fits the experimental data well and can be used in scale up design of the process.
authors.affiliation: Department of Chemical Engineering, The Ohio State University, 140 West 19th Avenue, Columbus, OH 43210, USA.
authors.forename: Hanjing
authors.initials: H
authors.lastname: Huang
authors.forename: Shang-Tian
authors.initials: ST
authors.lastname: Yang
authors.forename: David E
authors.initials: DE
authors.lastname: Ramey
mesh_terms: D001709:Biotechnology / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007773:Lactates / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry* / Q000302:isolation & purification*; D015233:Models, Statistical; D008962:Models, Theoretical; D000442:Octanols / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D007773:Lactates; D000442:Octanols; D012492:Salts; D014867:Water; D019344:Lactic Acid; D012972:Sodium Hydroxide; C067943:2-octanol