Parathyroid hormone-related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: a case presentation and subject review.
BACKGROUND
Serum levels of parathyroid hormone-related peptide (PTHrP) can be elevated with malignancy and cause hypercalcemia, which has been associated with a poor prognosis.


METHODS
We present a case of supraglottic squamous cell carcinoma with elevated serum PTHrP and hypercalcemia. The patient was acutely managed with intravenous fluids, furosemide, and zoledronic acid and then underwent a total laryngectomy and modified radical neck dissection. RESULTS.: The patient remains disease free and normocalcemic.


CONCLUSIONS
Curative treatment for patients with head and neck cancer should not be withheld solely on the basis of humoral hypecalcemia of malignancy.
Brawner
J Travis
JT
University of Missouri-Columbia School of Medicine, Columbia, Missouri, USA.
Zitsch
Robert P
RP
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000150:complications* / Q000601:surgery; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D007822:Laryngeal Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D037981:Neck Dissection / Q000379:methods; D044162:Parathyroid Hormone-Related Protein / Q000097:blood*; D036361:Peptide Hormones / Q000097:blood*
D044162:Parathyroid Hormone-Related Protein; D036361:Peptide Hormones