title: [Assessment of fructose-1,6-biphosphatase in urine of children with acute pyelonephritis].
abstract: We assessed the excretion of fructose-1,6-bisphosphatase (FBP) and N-acetyl-beta-D-glucosaminidase (NAG) in 52 children (aged 4.1 +/- 2.3): group I--26 children with acute pyelonephritis (APN), in whom the examination were carried out twice: A--before treatment, B--after 14-21 days of antibacterial treatment, group II--21 healthy children. Activity of FBP in urine was found in 80% children from group I and II, and activity of NAG was found in all children from both groups. In examination A mean excretion of FBP and NAG was higher than in healthy children (p < 0.05). After antibacterial treatment excretion of both enzymes decreased to values, which did not differ from control group (p > 0.05). High correlation between FBP and NAG (r = 0.9355; p = 0.00001) was shown only in 14 children, in whom the course of acute pyelonephritis was serious (CRP > 20 mg%, leucocytosis > 10 x 10(9), and renal swelling in ultrasonography).
  
  
  CONCLUSIONS
  Increased excretion of FBP in urine is found mainly in children with severe course of acute pyelonephritis, in whom the correlation between NAG and FBP is observed.
authors.affiliation: Klinika Chorób Dzieci Akademii Medycznej w Białymstoku.
authors.forename: Walentyna
authors.initials: W
authors.lastname: Zoch-Zwierz
authors.forename: Alina
authors.initials: A
authors.lastname: Kepka
authors.forename: Barbara
authors.initials: B
authors.lastname: Tomaszewska
authors.forename: Anna
authors.initials: A
authors.lastname: Wasilewska
authors.forename: Ryszard
authors.initials: R
authors.lastname: Wierciński
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Smółko
authors.forename: Wiesława
authors.initials: W
authors.lastname: Winiecka
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Porowski
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006597:Fructose-Bisphosphatase / Q000652:urine*; D006801:Humans; D008297:Male; D011704:Pyelonephritis / Q000188:drug therapy / Q000201:enzymology* / Q000652:urine; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D006597:Fructose-Bisphosphatase; D000118:Acetylglucosaminidase