title: BMI is the main determinant of the circulating leptin in women after vertical banded gastroplasty.
abstract: OBJECTIVE
  To assess the main determinant of serum leptin concentration changes in morbidly obese patients treated by banded vertical gastroplasty.
  
  
  METHODS
  Serum leptin and insulin concentrations, insulin resistance, BMI, body weight, and body fat mass in 18 obese women and 8 obese men treated by vertical banded gastroplasty were studied. Lean women and men subjects were used as controls.
  
  
  RESULTS
  Before surgery, serum leptin and insulin concentrations and insulin resistance index were significantly higher in morbidly obese patients than in control subjects. BMI, body fat mass, and serum triacylglycerol concentrations were also significantly higher in obese than in lean subjects. All of these parameters gradually decreased during 50 weeks after surgery. Univariate regression analysis displayed significant correlations between the following: serum leptin concentration and BMI (and body fat mass), serum leptin concentration and serum insulin concentration, and serum leptin concentration and insulin resistance index. Multivariate regression analysis indicated that only BMI was independently correlated with the decrease in serum leptin concentration.
  
  
  CONCLUSIONS
  Obtained data suggest the following: 1) vertical banded gastroplasty causes reduction of body weight, serum leptin and insulin concentration, insulin resistance, and serum triacylglycerol concentration; and 2) BMI is the main determinant of the circulating leptin concentration in morbidly obese women after anti-obesity surgery.
authors.affiliation: Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland.
authors.forename: Liolia
authors.initials: L
authors.lastname: Zabrocka
authors.forename: Sylwia
authors.initials: S
authors.lastname: Raczynska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Goyke
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Sledzinski
authors.forename: Julian
authors.initials: J
authors.lastname: Swierczynski
mesh_terms: D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D015391:Gastroplasty; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000601:surgery*; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D007328:Insulin; D020738:Leptin; D014280:Triglycerides