title: Unrelated peripheral blood and cord blood hematopoietic stem cell transplants for thalassemia major.
abstract: Allogeneic hematopoietic stem cell transplantation is currently the only curative treatment available for thalassemia major. While sibling donors are usually used, unrelated bone marrow transplants have also recently been found to be successful. In this report of two patients, we show that, besides using unrelated bone marrow, peripheral blood stem cell and cord blood transplantations from unrelated donors are viable options. We believe a significant contributory factor in both our cases was the large cell dose used.
authors.affiliation: Department of Hematology, Singapore General Hospital, Singapore.
authors.forename: Patrick Huat-Chye
authors.initials: PH
authors.lastname: Tan
authors.forename: William Ying Khee
authors.initials: WY
authors.lastname: Hwang
authors.forename: Yeow Tee
authors.initials: YT
authors.lastname: Goh
authors.forename: Poh Lin
authors.initials: PL
authors.lastname: Tan
authors.forename: Liang Piu
authors.initials: LP
authors.lastname: Koh
authors.forename: Cheng Hoe
authors.initials: CH
authors.lastname: Tan
authors.forename: Thuan Chong
authors.initials: TC
authors.lastname: Quah
mesh_terms: D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000628:therapy*