title: Impaired performance in a working memory binding task in patients with schizophrenia.
abstract: This study investigated feature binding in a working memory task in patients with schizophrenia and in normal controls. Twenty-five patients and 25 controls participated. On each trial, three drawings of familiar objects were presented sequentially, each in a different cell of a 3 x 3 grid. In different blocks of trials, participants remembered either individual features (object and location conditions) or an object and its location (combination condition). The results showed that patients were slower and less accurate than controls under all conditions. Accuracy of both groups was reduced in the combination condition relative to the single-feature conditions, but patients showed disproportionately poorer performance in the combination condition than in the object and location conditions. Thus, patients with schizophrenia exhibit deficits in working memory, particularly when the task requires binding objects to their locations. This finding demonstrates that processes that establish coherent and temporary episodic representations in working memory are impaired in schizophrenia.
authors.affiliation: INSERM U. 405, Psychopathologie et Pharmacologie de la Cognition, Department of Psychiatry, Hôpital Civil, 67091 Strasbourg Cedex, France.
authors.forename: Franck
authors.initials: F
authors.lastname: Burglen
authors.forename: Philippe
authors.initials: P
authors.lastname: Marczewski
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Mitchell
authors.forename: Martial
authors.initials: M
authors.lastname: van der Linden
authors.forename: Marcia K
authors.initials: MK
authors.lastname: Johnson
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Danion
authors.forename: Pierre
authors.initials: P
authors.lastname: Salamé
mesh_terms: D000328:Adult; D010054:Brief Psychiatric Rating Scale; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011930:Reaction Time; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology*; D012720:Severity of Illness Index; D014888:Wechsler Scales