Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides.
Reaction of the chiral crystals of the achiral amides with n-butyllithium in toluene at -80 degrees C gave optically active alcohols in 17-84% ee.
Sakamoto
Masami
M
Department of Materials Technology, Faculty of Engineering, Chiba University, Yayoi-cho, Chiba 263-8522, Japan. sakamotom@faculty.chiba-u.jp
Kobaru
Shuichiro
S
Mino
Takashi
T
Fujita
Tsutomu
T