title: Lymphoplasmacytic hyperplasia (possibly pre-PTLD) has varied expression and appearance in intestinal transplant recipients receiving Campath immunosuppression.
abstract: Posttransplant lymphoproliferative disorders (PTLD) are a frequent complication in bowel transplant recipients. Histological changes in PTLD range from expansile lymphoplasmacytic (LP) hyperplasia to frank lymphoma. Small bowel allograft biopsies obtained in the first 250 days posttransplant were retrospectively graded after patients had received induction immunosuppression with either anti-CD52 (Campath) or anti-CD25 (Zenapax) monoclonal antibodies. The biopsies were analyzed with respect to the onset intensity of lymphoplasmacytic infiltrates and presence of in situ EBV hybridization (EBER) positivity. We observed that lymphoplasmacytic infiltrates were a frequent change in all bowel transplant patients over the examined period. Campath-treated patients developed earlier LP infiltrates of mild to moderate intensity between day 1 and 100 posttransplant, thereafter decreasing to mild. No EBER positivity was detected in this group. Zenapax-treated patients presented with LP infiltrates later of mild to moderate intensity through day 100 posttransplant. However, more persistent and intense LP infiltrates was observed after day 101 in this group, including a case of lymphoma and two cases of EBER positivity. We conclude that Campath immunosuppression results in an earlier appearance of LP lesions that are generally less intense than those evident with Zenapax. We attribute these findings to the more profound immunodeficiency and cell targeting following Campath treatment.
authors.affiliation: Department of Pathology, University of Miami, Miami, Florida, USA. pruiz@med.miami.edu
authors.forename: P
authors.initials: P
authors.lastname: Ruiz
authors.forename: M F
authors.initials: MF
authors.lastname: Soares
authors.forename: M
authors.initials: M
authors.lastname: Garcia
authors.forename: M
authors.initials: M
authors.lastname: Nicolas
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: N
authors.initials: N
authors.lastname: Mittal
authors.forename: S
authors.initials: S
authors.lastname: Nishida
authors.forename: D
authors.initials: D
authors.lastname: Levi
authors.forename: G
authors.initials: G
authors.lastname: Selvaggi
authors.forename: J
authors.initials: J
authors.lastname: Madariaga
authors.forename: A
authors.initials: A
authors.lastname: Tzakis
mesh_terms: D000074323:Alemtuzumab; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000009:adverse effects*; D000077561:Daclizumab; D006801:Humans; D006965:Hyperplasia; D007074:Immunoglobulin G / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D007422:Intestines / Q000473:pathology / Q000637:transplantation; D008232:Lymphoproliferative Disorders / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors; D014184:Transplantation, Homologous / Q000473:pathology*; D014781:Viscera / Q000637:transplantation
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D000074323:Alemtuzumab; D000077561:Daclizumab