Review article: current management of alcoholic liver disease.
Alcoholic liver disease, including acute alcoholic hepatitis and alcoholic cirrhosis, is a major cause of morbidity and mortality in the Western world. Abstinence remains the cornerstone of management of all forms of alcoholic liver disease. Recent research, which has elucidated the mechanisms of alcohol-induced liver injury, offers the prospect of advances in the management of alcoholic liver disease. We review the most recent data on the efficacy of treatment of acute alcoholic injury, including nutritional support, corticosteroids, anti-inflammatory agents and antioxidants, and agents that are directed against the progression to fibrosis, such as colchicines, propylthiouracil and antioxidants. Although these therapies offer a tantalizing glimpse into a future that may include therapies that directly alter the process of injury and repair in the liver, none has been shown consistently to improve the course of alcoholic liver damage. Consequently, liver transplantation remains an ultimate option for selected patients with liver failure due to chronic alcoholic liver damage.
Tome
S
S
Liver Unit, Internal Medicine Department, Complejo Hospitalario Universitario de Santiago de Compostela, Spain.
Lucey
M R
MR
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000437:Alcoholism / Q000534:rehabilitation; D003078:Colchicine / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006505:Hepatitis / Q000628:therapy; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000209:etiology / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods; D010713:Phosphatidylcholines / Q000627:therapeutic use; D011379:Prognosis; D013695:Temperance; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000305:Adrenal Cortex Hormones; D016166:Free Radical Scavengers; D010713:Phosphatidylcholines; D014409:Tumor Necrosis Factor-alpha; D003078:Colchicine