title: [Hamartomatous polyposis syndromes].
abstract: Hamartomatous polyposis syndromes are characterized by an overgrowth of cells or tissues native to the area in which they normally occur. Peutz-Jeghers syndrome and juvenile polyposis are both characterized by the presence of hamartomatous polyps and increased risk of malignancy in the gastrointestinal tract. Cowden's disease is associated with germ-line mutations in the PTEN gene (10q22-23) and an increased risk of breast and thyroid malignancies. Ruvalcaba-Myhre-Smith syndrome is less common; controversy suggests that it may represent a variant of Cowden's disease.
authors.forename: Giandominik
authors.initials: G
authors.lastname: Bossone
authors.forename: Nello
authors.initials: N
authors.lastname: Salesi
authors.forename: Federico
authors.initials: F
authors.lastname: Alghisi
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Cocco
mesh_terms: D006801:Humans; D010580:Peutz-Jeghers Syndrome / Q000145:classification / Q000175:diagnosis