[Nonmyeloablative allogeneic stem cell transplantation for a 70-year-old woman with relapsed acute myelogenous leukemia].
We describe a 70-year-old woman with acute myelogenous leukemia with t(8;21) in the first relapse who underwent nonmyeloablative transplantation with conditioning of fludarabine and low-dose total body irradiation (2Gy). Myelosuppression was very mild, and the patient developed transient grade I renal and hepatic toxicities. Complete chimerism was achieved on day 120. The level of the AML1/MTG8 fusion gene in bone marrow decreased to an undetectable level on day 56 and the patient is alive and in complete remission with a follow-up at day 450. This transplant regimen might be well tolerated even by the elderly patients and bring a durable remission.
Nagasawa
Eriko
E
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University.
Abe
Yasunobu
Y
Matsushima
Takamitsu
T
Choi
Ilseung
I
Tachikawa
Yoshimichi
Y
Ohtsuka
Rie
R
Ishikura
Hideki
H
Nishimura
Junji
J
Inaba
Shoichi
S
Nawata
Hajime
H
Muta
Koichiro
K
D000368:Aged; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D033581:Stem Cell Transplantation; D019172:Transplantation Conditioning / Q000379:methods