title: Clonal relatedness of erythromycin-resistant Streptococcus pyogenes isolates in Germany.
abstract: In a nationwide study in Germany, a total of 381 Streptococcus pyogenes were collected. Erythromycin A-resistant strains were characterized for the underlying resistance genotype, showing 55.6% had the efflux type mef(A), 31.5% had erm(A), and 13.0% had erm(B). A total of 23 different multilocus sequence types were observed.
authors.affiliation: Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, D-52057 Aachen, Germany. Reinert@rwth-aachen.de
authors.forename: Ralf R
authors.initials: RR
authors.lastname: Reinert
authors.forename: Rudolf
authors.initials: R
authors.lastname: Lütticken
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Sutcliffe
authors.forename: Amelia
authors.initials: A
authors.lastname: Tait-Kamradt
authors.forename: Murat Y
authors.initials: MY
authors.lastname: Cil
authors.forename: Holger M
authors.initials: HM
authors.lastname: Schorn
authors.forename: André
authors.initials: A
authors.lastname: Bryskier
authors.forename: Adnan
authors.initials: A
authors.lastname: Al-Lahham
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C117866:MefA protein, Streptococcus; D008565:Membrane Proteins; D004917:Erythromycin; D008780:Methyltransferases; C431709:ErmA protein, Bacteria