title: Synthesis of 4-formyl-4-imidazolin-2-one nucleosides, isomers of uridine and 2'-deoxyuridine.
abstract: The syntheses of the ribo- and deoxyribonucleoside derivatives of 4-formyl-4-imidazolin-2-one, isosteric isomers of uridine and 2'-deoxyuridine, respectively, were carried out by ring contraction of the corresponding 5-bromouracil nucleosides, followed by conversion of the carboxyl side-chain of the products to the respective carboxaldehyde derivatives.
authors.affiliation: Department of Chemistry, University at Buffalo, Amherst, New York 14260, USA.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Thomas I
authors.initials: TI
authors.lastname: Kalman
mesh_terms: D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: C407206:4-formyl-4-imidazolin-2-one; D007093:Imidazoles; D003857:Deoxyuridine; D014529:Uridine