Cytotoxic isoprenylated xanthones from Cudrania tricuspidata.
Eight new isoprenylated xanthones, cudratricusxanthones A-H (1-8), were isolated from the roots of Cudrania tricuspidata, together with ten known compounds, cudraxanthones H (9) and M (10), xanthone V(1a) (11), toxyloxanthone C (12), macluraxanthone B (13), 1-hydroxy-3, 6, 7-trimethoxyxanthone (14), cycloartocarpesin (15), artocarpesin (16), cudraflavone B (17), and kaempferol (18). Their structures were characterized by spectroscopic methods. Xanthones 5, 7, 10, and 12 showed inhibitory effects on four kinds of human digestive apparatus tumor cell lines (HCT-116, SMMC-7721, SGC-7901, and BGC-823) with IC(50) values of 1.6-11.8 microg/mL. Xanthones 2, 4, and 11 displayed significant cytotoxicity against HCT-116, SMMC-7721, and SGC-7901 (IC(50)=1.3-9.8 microg/mL). Flavonoids 15-17 were almost inactive.
Zou
Ying-Shu
YS
Department of Pharmacognosy, School of Pharmacy, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People's Republic of China.
Hou
Ai-Jun
AJ
Zhu
Guo-Fu
GF
Chen
Yan-Feng
YF
Sun
Han-Dong
HD
Zhao
Qin-Shi
QS
D000970:Antineoplastic Agents / Q000633:toxicity; D045744:Cell Line, Tumor; D006801:Humans; D029586:Moraceae; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018517:Plant Roots; D017368:Protein Prenylation; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
D000970:Antineoplastic Agents; D010936:Plant Extracts; D044004:Xanthones