title: Functional obstruction: the renal pelvis rules.
abstract: Failure in the peristaltic mechanism that conducts urine from the kidney to the bladder can lead to hydronephrosis, a common birth defect associated with obstructive nephropathy. New animal models reveal molecular pathways important for peristalsis and point to the central role of the renal pelvis in urine transport.
authors.affiliation: Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA. clm20@columbia.edu
authors.forename: Cathy
authors.initials: C
authors.lastname: Mendelsohn
mesh_terms: D019703:Calcineurin / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D014513:Ureter / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology
chemical_list: D006133:Growth Substances; D019703:Calcineurin