Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives.
(+)-Deoxoartemisitene and its C-11, 13 derivatives were synthesized from artemisinic acid via a short and regiospecific process and several derivatives show 10-20 times more in vitro antimalarial activities against Plasmodium falciparum than artemisinin.
Jung
Mankil
M
Department of Chemistry, Yonsei University, Seoul 120-749, South Korea. mjung@yonsei.ac.kr
Lee
Kyunghoon
K
Jung
Hochul
H
Kendrick
Howard
H
Yardley
Vanessa
V
Croft
Simon L
SL
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D037621:Artemisinins; C492892:deoxoartemisitene