title: Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient.
abstract: We report a linezolid-resistant Enterococcus faecalis infection in a cord blood stem cell transplant recipient previously treated with linezolid for bloodstream infections by vancomycin-resistant enterococci. Sequencing showed a G2576U mutation in the 23S rRNA gene. Because of the important niche of linezolid in cancer treatment, linezolid-resistant E. faecalis is noteworthy.
authors.affiliation: Department of Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
authors.forename: Imad
authors.initials: I
authors.lastname: Dibo
authors.forename: Satish K
authors.initials: SK
authors.lastname: Pillai
authors.forename: Howard S
authors.initials: HS
authors.lastname: Gold
authors.forename: Maria R
authors.initials: MR
authors.lastname: Baer
authors.forename: Meir
authors.initials: M
authors.lastname: Wetzler
authors.forename: James L
authors.initials: JL
authors.lastname: Slack
authors.forename: Peggy A
authors.initials: PA
authors.lastname: Hazamy
authors.forename: Donna
authors.initials: D
authors.lastname: Ball
authors.forename: Chiu Bin
authors.initials: CB
authors.lastname: Hsiao
authors.forename: Philip L
authors.initials: PL
authors.lastname: McCarthy
authors.forename: Brahm H
authors.initials: BH
authors.lastname: Segal
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D017422:Sequence Analysis, DNA; D033581:Stem Cell Transplantation / Q000009:adverse effects*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D012338:RNA, Ribosomal, 23S; D000069349:Linezolid