title: [Changes of connexin 43 in rabbit with early myocardial ischemia].
abstract: OBJECTIVE
  To reveal gap junction connexin 43 (Cx43) in rabbit with early myocardial ischemia.
  
  
  METHODS
  The left coronary arteries were ligated to create early myocardial ischemia. Cx43 was visualized by use of SP immunohistochemical method (IHC) and Colloidal gold of the electron microscopy, and a comparison was made between the experiment group and the control group. The semi-quantitation assessment was performed.
  
  
  RESULTS
  The positive areas of Cx43 gap junctions by IHC and Colloidal gold particles of the electron microscopy were found decreased by about 40% at 30 minutes of acute myocardial ischemia. The distributions were not obviously modified.
  
  
  CONCLUSIONS
  The decrease of Cx43 is characterized by the time during myocardial ischemia, and the early stage of acute myocardial ischemia in rat is of positive significance.
authors.affiliation: Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Hua-zi
authors.initials: HZ
authors.lastname: Hu
authors.forename: Jia-wen
authors.initials: JW
authors.lastname: Wu
authors.forename: Qi-yi
authors.initials: QY
authors.lastname: Peng
authors.forename: Guo
authors.initials: G
authors.lastname: Yang
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Liao
mesh_terms: D000818:Animals; D018031:Connexin 43 / Q000378:metabolism*; D005260:Female; D017629:Gap Junctions / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D011817:Rabbits; D011897:Random Allocation; D013997:Time Factors
chemical_list: D018031:Connexin 43