Prognostic value of VEGF in human pancreatic ductal adenocarcinoma.
BACKGROUND
Since pancreatic cancer metastasizes early regardless of the size of the primary tumor, it is suggested that angiogenic factor is upregulated in this disease. Among the angiogenic factors, vascular endothelial growth factor (VEGF) is the most potent and specific growth factor. The aim of this study is to elucidate the prognostic value of VEGF expression in pancreatic cancers.


METHODS
We analyzed the VEGF expression using immunohistochemistry in 72 resected pancreatic ductal adenocarcinomas. We examined the prognostic value of the VEGF expression along with its relationship with the clinicopathological features.


RESULTS
VEGF expression and mutant p53 expression were not associated with microvessel density. VEGF expression was positively associated with mutant p53 expression. There were no statistically significant relationships between the VEGF expression and other clinicopathological features, such as age, sex, CA19-9, tumor size, location, tumor differentiation, and stage. VEGF expression was not associated with patient survival.


CONCLUSIONS
VEGF expression was not associated with the microvessel density and patient survival in pancreatic ductal adenocarcinoma.
Lim
Yun Jeong
YJ
Center for Health promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Lee
Jong Kyun
JK
Park
Cheol Keun
CK
Song
Sang Yong
SY
Jang
Woo Young
WY
Ha
Hye Young
HY
Park
Dong Il
DI
Lee
Kyu Taek
KT
Paik
Seung Woon
SW
Yoo
Byung Chul
BC
Rhee
Jong Chul
JC
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000601:surgery; D011379:Prognosis; D016019:Survival Analysis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A