title: Development of an inexpensive, low attenuation styrofoam primate chair for use in a PET scanner.
abstract: Pharmacokinetic modelling of radiotracers for positron emission tomography (PET) imaging of neuroreceptors can be performed with time-activity data for brain and blood. We aimed to develop an alternative to withdrawal of arterial blood samples for acquisition of a blood curve. A supportive primate chair was constructed out of styrofoam and fixed to the head portion of the bed of a PET scanner. A lightly anaesthetised rhesus monkey was positioned in the chair in a sitting position and injected with the radiotracer. The styrofoam chair provided sufficient support for the monkey. The presence of the chair in the PET scanner caused negligible attenuation of radiation, allowing simultaneous acquisition of dynamic data from the subject's brain and heart. We conclude that a styrofoam primate chair is an ideal tool to measure blood and brain data from a rhesus monkey with PET. Invasiveness to the animal is reduced, as well as experimenter time.
authors.affiliation: Department of Neurology, Groningen University Hospital, Groningen, The Netherlands. r.kortekaas@neuro.azg.nl
authors.forename: R
authors.initials: R
authors.lastname: Kortekaas
authors.forename: A
authors.initials: A
authors.lastname: van Waarde
authors.forename: R P
authors.initials: RP
authors.lastname: Maguire
authors.forename: K L
authors.initials: KL
authors.lastname: Leenders
authors.forename: P H
authors.initials: PH
authors.lastname: Elsinga
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics; D008253:Macaca mulatta; D008297:Male; D011137:Polystyrenes; D011849:Radioactive Tracers; D011984:Sensory Receptor Cells / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; D011137:Polystyrenes; D011849:Radioactive Tracers; C024075:styrofoam