title: Non-randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema and tissue fibrosis after radiotherapy for early breast cancer.
abstract: BACKGROUND
  Radiation-induced arm lymphoedema is a common and distressing complication of curative treatment for early breast cancer. Hyperbaric oxygen (HBO(2)) therapy promotes healing in bone rendered ischaemic by radiotherapy, and may help some soft-tissue injuries too, but is untested in arm lymphoedema.
  
  
  METHODS
  Twenty-one eligible research volunteers with a minimum 30% increase in arm volume in the years after axillary/supraclavicular radiotherapy (axillary surgery in 18/21 cases) were treated with HBO(2). The volunteers breathed 100% oxygen at 2.4 ATA for 100 min in a multiplace hyperbaric chamber on 30 occasions over a period of 6 weeks. The volume of the ipsilateral limb, measured opto-electronically by a perometer and expressed as a percentage of contralateral limb volume, was selected as the primary endpoint. A secondary endpoint was local lymph drainage expressed as fractional removal rate of radioisotopic tracer, measured using lymphoscintigraphy.
  
  
  RESULTS
  Three out of 19 evaluable patients experienced >20% reduction in arm volume at 12 months. Six out of 13 evaluable patients experienced a >25% improvement in (99)Tc-nanocolloid clearance rate from the ipsilateral forearm measured by quantitative lymphoscintigraphy at 12 months. Overall, there was a statistically significant, but clinically modest, reduction in ipsilateral arm volume at 12 months follow-up compared with baseline (P = 0.005). The mean percentage reduction in arm volume from baseline at 12 months was 7.51. Moderate or marked lessening of induration in the irradiated breast, pectoral fold and/or supraclavicular fossa was recorded clinically in 8/15 evaluable patients. Twelve out of 19 evaluable patients volunteered that their arms felt softer, and six reported improvements in shoulder mobility at 12 months. No significant improvements were noted in patient self-assessments of quality of life.
  
  
  CONCLUSIONS
  Interpretation is limited by the absence of a control group. However, measurement of limb volume by perometry is reportedly reliable, and lymphoscintigraphy is assumed to be operator-independent. Taking all data into account, there is sufficient evidence to justify a double-blind randomised controlled trial of hyperbaric oxygen in this group of patients.
authors.affiliation: Department of Radiotherapy, Royal Marsden NHS Trust, Sutton, Surrey SM2 5PT, UK.
authors.forename: Lone
authors.initials: L
authors.lastname: Gothard
authors.forename: Anthony
authors.initials: A
authors.lastname: Stanton
authors.forename: Julie
authors.initials: J
authors.lastname: MacLaren
authors.forename: David
authors.initials: D
authors.lastname: Lawrence
authors.forename: Emma
authors.initials: E
authors.lastname: Hall
authors.forename: Peter
authors.initials: P
authors.lastname: Mortimer
authors.forename: Eileen
authors.initials: E
authors.lastname: Parkin
authors.forename: Joyce
authors.initials: J
authors.lastname: Pritchard
authors.forename: Jane
authors.initials: J
authors.lastname: Risdall
authors.forename: Robert
authors.initials: R
authors.lastname: Sawyer
authors.forename: Mary
authors.initials: M
authors.lastname: Woods
authors.forename: John
authors.initials: J
authors.lastname: Yarnold
mesh_terms: D000368:Aged; D000886:Anthropometry; D001132:Arm / Q000473:pathology; D001943:Breast Neoplasms / Q000532:radiotherapy*; D018567:Breast Neoplasms, Male / Q000532:radiotherapy; D002908:Chronic Disease; D005260:Female; D005355:Fibrosis; D006801:Humans; D006931:Hyperbaric Oxygenation; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008209:Lymphedema / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011832:Radiation Injuries / Q000628:therapy*; D011877:Radionuclide Imaging; D017695:Soft Tissue Injuries / Q000473:pathology / Q000628:therapy