How good are quantitative complementation tests?
Several recent studies have used quantitative complementation tests to identify relatively short chromosome regions that contain genes that influence life span and to screen for candidate life-span genes in flies. The methodology and logic of quantitative complementation tests are described. Arguments are presented that suggest that these tests may be misleading because there is a substantial, but unknown, likelihood of false positive results. The arguments are supported by the published results of quantitative complementation tests.
Service
Philip M
PM
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA. Philip.Service@nau.edu
D000818:Animals; D005816:Genetic Complementation Test / Q000379:methods* / Q000592:standards*; D040641:Quantitative Trait Loci