Micronuclei induced by municipal landfill leachate in mouse bone marrow cells in vivo.
The induction of micronuclei (MN) in polychromatic erythrocytes (PCE) of mouse bone marrow by municipal landfill leachate was studied in vivo. Results showed that mouse exposure via drinking water containing various concentrations of leachate caused a significant increase of MN frequencies in a concentration (Chemical oxygen demand measured with potassium dichromate oxidation, COD(Cr))-dependent manner. MN induction in female and male mice was different at higher concentrations. This implies that leachate is a genotoxic agent in mammalian cells and that exposure to leachate in an aquatic environment may pose a potential genotoxic risk to human beings.
Li
Guangke
G
College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China. sangnan_lgkcarl@163.com
Sang
Nan
N
Zhao
Youcai
Y
D000818:Animals; D001854:Bone Marrow Cells; D002681:China; D004781:Environmental Exposure; D004900:Erythroblasts / Q000187:drug effects*; D005260:Female; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D012037:Refuse Disposal; D012737:Sex Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D014874:Water Pollutants, Chemical