title: Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes.
abstract: The intramolecular addition of beta-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity.
authors.affiliation: Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Kennedy-Smith
authors.forename: Steven T
authors.initials: ST
authors.lastname: Staben
authors.forename: F Dean
authors.initials: FD
authors.lastname: Toste