title: Iridoids as allelochemicals and DNA polymerase inhibitors.
abstract: Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a pi-pi charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.
authors.affiliation: INTEQUI-CONICET, Laboratorio de Biología Molecular, and Area de Zoología, Facultad de Química Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700-San Luis, Argentina.
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Pungitore
authors.forename: Maximiliano Juri
authors.initials: MJ
authors.lastname: Ayub
authors.forename: Matías
authors.initials: M
authors.lastname: García
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Borkowski
authors.forename: Marta E
authors.initials: ME
authors.lastname: Sosa
authors.forename: Gladys
authors.initials: G
authors.lastname: Ciuffo
authors.forename: Oscar S
authors.initials: OS
authors.lastname: Giordano
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Tonn
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007300:Insect Control; D057888:Iridoid Glucosides; D057889:Iridoid Glycosides; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014231:Tribolium / Q000187:drug effects*
chemical_list: D004791:Enzyme Inhibitors; D005960:Glucosides; D057888:Iridoid Glucosides; D057889:Iridoid Glycosides; D039823:Iridoids; D019384:Nucleic Acid Synthesis Inhibitors; D011714:Pyrans; C078040:catalpol; C077626:8-O-acetylharpagide; C033250:harpagide