title: Liver-type fatty acid-binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma.
abstract: OBJECTIVE
  To investigate the relation of liver-type fatty-acid-binding protein (L-FABP) expression to the clinicopathological characteristics or the fatty acid synthase status of gastric cancers.
  
  
  METHODS
  L-FABP expression was examined immunohistochemically in 667 gastric cancers, 60 gastric adenomas, and non-neoplastic epithelium contiguous with cancer tissue including normal foveolae, intestinal metaplasia, regenerative epithelium, and gastric glands.
  
  
  RESULTS
  L-FABP was positive in 38% (high in 9% and low in 29%) of gastric cancers. It occurred preferentially in papillary carcinomas, female cases, and in patients under 50 years. In gastric cancers, L-FABP expression had no intimate correlation with the FAS status, and it showed no relationship with prognosis and cancer progression as indicated by venous and lymphatic permeation, and nodal or hepatic metastasis. Gastric tubular adenomas mainly revealed low (22%) expression of L-FABP while intestinal metaplasia showed the most frequent (>95%) and intense L-FABP expression. Normal foveolae and gastric glands showed no or less L-FABP expression.
  
  
  CONCLUSIONS
  L-FABP is highly and intensely expressed in metaplasia and in a subset of gastric adenocarcinomas, without association with progression, prognosis and fatty acid synthase status of the carcinoma.
authors.affiliation: Department of Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kusakabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugino
authors.forename: Takeaki
authors.initials: T
authors.lastname: Fukuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nashimoto
authors.forename: Kei-Ichi
authors.initials: K
authors.lastname: Honma
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sato
authors.forename: Hideki
authors.initials: H
authors.lastname: Kimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality / Q000556:secondary; D000236:Adenoma / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D000943:Antigens, Differentiation / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D064429:Fatty Acid Synthases / Q000378:metabolism*; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
chemical_list: D000943:Antigens, Differentiation; D002352:Carrier Proteins; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D064429:Fatty Acid Synthases