title: Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease.
abstract: Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C-->T and 1298 A-->C) and transcobalamin genes (TCN1 776 C-->G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677T (odds ratio 6.28, 95% CI 2.88-16.20, p < 0.0001) and APOE epsilon4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677T and APOE epsilon4 alleles.
authors.affiliation: IRCCS Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina (EN), Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Anello
authors.forename: Rosa-Maria
authors.initials: RM
authors.lastname: Guéant-Rodríguez
authors.forename: Paolo
authors.initials: P
authors.lastname: Bosco
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Guéant
authors.forename: Antonino
authors.initials: A
authors.lastname: Romano
authors.forename: Bernard
authors.initials: B
authors.lastname: Namour
authors.forename: Rosario
authors.initials: R
authors.lastname: Spada
authors.forename: Filippo
authors.initials: F
authors.lastname: Caraci
authors.forename: Gregory
authors.initials: G
authors.lastname: Pourié
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Daval
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
mesh_terms: D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011624:Pteroylpolyglutamic Acids / Q000627:therapeutic use; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D014155:Transcobalamins / Q000235:genetics / Q000378:metabolism; D014805:Vitamin B 12 / Q000627:therapeutic use
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D011624:Pteroylpolyglutamic Acids; D014155:Transcobalamins; D006710:Homocysteine; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D014805:Vitamin B 12