title: Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002.
abstract: The aim of the present study was to determine the change of serum uric acid (UA) levels in male adolescents and to characterize the relationship between UA levels and obesity or its related factors. This study was conducted in 17,155 students at enrollment in Okayama University from 1991 through 2002, in which the mean serum UA level as a whole was 5.64 +/- 0.009 mg/dL (mean +/- SEM) and the incidence of hyperuricemia (>/=7.6 mg/dL) was 4.13%. Serum UA levels were correlated with obesity-related indicators, including body mass index (BMI; r = 0.282, P <.0001) and skin-fold thickness (r = 0.286, P <.0001). The incidence of hyperuricemia was increased in parallel with BMI. In the last 4 years (1999 through 2002) of the study period, serum UA levels (5.76 mg/dL) and the incidence of hyperuricemia (4.5%) were significantly increased compared with those in the earlier period (1991 through 1994: 5.50 mg/dL and 3.5%, respectively). However, BMI has been rather gradually decreased throughout 12-year observation in all the subjects. Hyperuricemia was related to the presence of other risk factors, including hypercholesterolemia, liver function abnormality, and hypertension. The frequencies of such abnormalities were higher than euuricemic subjects and this trend was notable in the most recent students enrolled from 1999 through 2002. Hyperuricemia was even found in the group of non-obese male adolescents. Taking into consideration that hyperuricemia is associated with a high prevalence of lifestyle-related diseases in adults, it is of great importance to prevent hyperuricemia at the early stage in Japanese adolescents.
authors.affiliation: Health and Medical Center, Okayama University, Okayama, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Ogura
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Matsuura
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Yukari
authors.initials: Y
authors.lastname: Mimura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kishida
authors.forename: Fumio
authors.initials: F
authors.lastname: Otsuka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tobe
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology*; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D012885:Skinfold Thickness; D013223:Statistics as Topic; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid; D002784:Cholesterol; D000410:Alanine Transaminase