title: Immune complex-type glomerulonephritis with unusual giant deposits in a patient with active rheumatoid arthritis.
abstract: A 61-year-old woman with rheumatoid arthritis (RA) developed small digital ulcers, proteinuria, and hematuria. Serological studies disclosed high titers of antinuclear antibody and rheumatoid factors (RF; IgM-RF and IgG-RF), and an increased level of circulating immune complexes. These findings suggested an active immunological state of RA. A renal biopsy showed periodic acid-Schiff-positive giant deposits in the mesangial area and subepithelial space. Immunofluorescence microscopy revealed strong stainings for IgG, IgA, IgM, Kappa, Lambda, C3, C1q, and fibrinogen in a granular pattern. Electron microscopy showed giant granular deposits (diameter, up to 4.6 micro m) without specific fibrillary structure in the mesangial area and subepithelial space, and partially in the subendothelial space. There were no findings of vasculitis, such as endothelial proliferation or fibrinoid necrosis of small arteries. This is the first report of immune complex-type glomerulonephritis with unusual giant deposits in a patient with RA in an active immunological state.
authors.affiliation: Third Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Akita, Japan. ohtanih@doc.med.akita-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtani
authors.forename: Hideki
authors.initials: H
authors.lastname: Wakui
authors.forename: Atsushi
authors.initials: A
authors.lastname: Komatsuda
authors.forename: Shin
authors.initials: S
authors.lastname: Okuyama
authors.forename: Rie
authors.initials: R
authors.lastname: Masai
authors.forename: Nobuki
authors.initials: N
authors.lastname: Maki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kigawa
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sawada
mesh_terms: D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D005260:Female; D005455:Fluorescent Antibody Technique; D005920:Glomerular Mesangium / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000097:blood
chemical_list: D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor