Retrograde regulation in the CNS; neuron-specific interpretations of TGF-beta signaling.
Retrograde signals influence neuronal survival, differentiation, synaptogenesis, and plasticity. Several recent papers describe novel roles for the well-studied TGF-beta pathway in retrograde synaptic signaling. While each dissects spatial and molecular aspects of TGF-beta signaling in a specific synaptic context, together these studies demonstrate that a specific retrograde signal may be interpreted in diverse, neuron-specific ways. Thus, a neuron's intrinsic properties and its other extrinsic signaling inputs determine its cellular and genomic response to TGF-beta.
Sanyal
Subhabrata
S
Department of Molecular and Cellular Biology and ARL Division of Neurobiology, Box 210106, University of Arizona, Tucson, AZ 85721, USA.
Kim
Susy M
SM
Ramaswami
Mani
M
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009046:Motor Neurons / Q000166:cytology / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D016212:Transforming Growth Factor beta