Gold(I)-catalyzed Conia-ene reaction of beta-ketoesters with alkynes.
The intramolecular addition of beta-ketoesters to unactivated alkynes under neutral conditions and at room temperature is described. The method employs triphenylphosphinegold(I) cation as a catalyst for the formation of exo-methylenecycloalkanes. Both monocyclic and bicyclic cyclopentanes and cyclohexanes can be formed in excellent yields and with good diastereoselectivity.
Kennedy-Smith
Joshua J
JJ
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, California 94720, USA.
Staben
Steven T
ST
Toste
F Dean
FD