title: [Diagnosis and treatment for adrenocortical carcinoma].
abstract: Adrenocortical carcinomas frequently hypersecrete multiple adrenocortical steroids and their precursors. CT scan and MRI usually demonstrate necrotic lesions or areas of calcification in this uncommon tumor. Therapy in patients with adrenocortical carcinoma is less satisfactory. Surgical excision is the primary mode of therapy. Up to the present, mitotane (o, p'-DDD) treatment combined with chemotherapy has been the only palliative measure for patients with nonresectable or extensively recurrent tumors.
authors.affiliation: Dept. of Endocrine Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Iihara
authors.forename: Takao
authors.initials: T
authors.lastname: Obara
mesh_terms: D000302:Adrenal Cortex / Q000000981:diagnostic imaging; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002784:Cholesterol; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008939:Mitotane / Q000008:administration & dosage; D011379:Prognosis; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
chemical_list: D018931:Antineoplastic Agents, Hormonal; D007457:Iodine Radioisotopes; D005047:Etoposide; D008939:Mitotane; D004317:Doxorubicin; D002784:Cholesterol; D002945:Cisplatin