Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema.
We describe a patient who had recurrent life-threatening episodes of isolated macroglossia due to the use of an angiotensin-converting enzyme (ACE) inhibitor. No associated facial, labial, pharyngeal, or laryngeal edema was noted. Aggressive treatment with epinephrine, steroids, and antihistamines resulted in rapid resolution of the tongue swelling and respiratory distress. Recurrent isolated angioedema of the tongue is an extremely rare variant of ACE inhibitor-related angioneurotic edema. The widespread use of ACE inhibitors mandates a special awareness by physicians of this potentially life-threatening yet treatable side effect.
Elinav
Eran
E
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Rabinowitz
Yaacov
Y
Lorberbaum
Miriam
M
Nisanewitz
Vadim
V
D000368:Aged; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D004656:Enalapril / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008260:Macroglossia / Q000139:chemically induced*; D008297:Male
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril