title: Quinone reductase-mediated nitro-reduction: clinical applications.
authors.affiliation: Enact Pharma PLC, Salisbury, United Kingdom.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Knox
authors.forename: Shiuan
authors.initials: S
authors.lastname: Chen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D001388:Aziridines / Q000737:chemistry / Q000493:pharmacokinetics; D001711:Biotransformation; D002986:Clinical Trials as Topic; D006801:Humans; D008969:Molecular Sequence Data; D009601:Nitroreductases / Q000378:metabolism*; D011355:Prodrugs / Q000737:chemistry / Q000493:pharmacokinetics; D011808:Quinone Reductases / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D001388:Aziridines; D011355:Prodrugs; C100099:tretazicar; D011808:Quinone Reductases; D009601:Nitroreductases