title: Synthesis of conformationally restricted 2,3-diarylbenzo[b]furan by the Pd-catalyzed annulation of o-alkynylphenols: exploring a combinatorial approach.
abstract: The palladium/bpy-catalyzed annulation of o-alkynylphenol with various aryl halides to generate diversified 2,3-diarylbenzo[b]furan is herein described. This method provides an efficient synthetic pathway for the combinatorial synthesis of conformationally restricted 2,3-diarylbenzo[b]furan for drug discovery.
authors.affiliation: VivoQuest, Inc., 711 Executive Boulevard, Valley Cottage, New York 10989, USA.
authors.forename: Youhong
authors.initials: Y
authors.lastname: Hu
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Nawoschik
authors.forename: Yun
authors.initials: Y
authors.lastname: Liao
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Reza
authors.initials: R
authors.lastname: Fathi
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001572:Benzofurans; D007202:Indicators and Reagents; D010636:Phenols; D010165:Palladium