title: Middle-latency auditory-evoked potential in acepromazine-sedated dogs.
abstract: The middle-latency auditory-evoked potential (MLAEP) has been investigated as means of monitoring anesthesia in dogs. The goals of this study were to develop a technique to record MLAEPs in awake dogs and to determine the effects of sedation. The MLAEP was recorded in 12 dogs with and without sedation with acepromazine. Three needle electrodes were inserted SC. Click stimuli were delivered biaurally. Signal acquisition, averaging, and analysis were performed by software developed in-house. Signals were recorded for 128 milliseconds, and the responses to 1,024 stimuli were averaged. The waveforms from 10 recordings were averaged, and the amplitudes and latencies of peaks that could be consistently identified were measured. Data measured were compared by means of a paired 2-sided Student's t-test. Interpretable MLAEPs were recorded in 10 of the 12 dogs. Three peaks were consistently identified (Pa, Nb, and Pb). The latencies of these peaks were significantly (P = .032, .035, and .028, respectively) shorter in awake (mean +/- SD milliseconds) (Pa = 18.85 +/- 1.36, Nb = 30.50 +/- 3.55, and Pb = 47.70 +/- 5.53) than in sedated (Pa = 22.40 +/- 3.88, Nb = 35.75 +/- 6.77, and Pb = 55.30 +/- 10.55) dogs. The Pb amplitude was not significantly different (2.51 +/- 1.30 microV awake and 2.19 +/- 1.10 microV sedated). This study demonstrates that acepromazine sedation causes changes in MLAEP.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Utrecht University, P.O. Box 80154, NL-3508 TD Utrecht, The Netherlands. j.c.nurrell@vet.uu.nl
authors.forename: Joanna C
authors.initials: JC
authors.lastname: Murrell
authors.forename: H N M
authors.initials: HN
authors.lastname: de Groot
authors.forename: A J
authors.initials: AJ
authors.lastname: Venker-van Haagen
authors.forename: W E
authors.initials: WE
authors.lastname: van den Brom
authors.forename: L J
authors.initials: LJ
authors.lastname: Hellebrekers
mesh_terms: D000075:Acepromazine / Q000008:administration & dosage / Q000494:pharmacology*; D000161:Acoustic Stimulation / Q000295:instrumentation / Q000662:veterinary*; D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001364:Awareness / Q000502:physiology; D004285:Dogs / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male
chemical_list: D006993:Hypnotics and Sedatives; D000075:Acepromazine