title: Reovirus type 2 isolated from cerebrospinal fluid.
abstract: An 8-week-old female infant presented with a history of active varicella complicated by Escherichia coli sepsis, oral thrush, hypoalbuminemia, intermittent fevers, diarrhea and feeding intolerance. Rhesus monkey kidney cells inoculated with cerebrospinal fluid revealed reovirus-like particles by electron microscopy. Virus neutralization and RNA-gel electrophoresis studies identified the isolated pathogen as reovirus serotype 2. This report represents one of only a few to isolate reovirus from the central nervous system in humans.
authors.affiliation: Department of Medical Microbiology and Infectious Disease, University of Manitoba, 511-730 William Avenue, Winnipeg, Manitoba R3E 0W3, Canada.
authors.forename: Laura
authors.initials: L
authors.lastname: Hermann
authors.forename: Joanne
authors.initials: J
authors.lastname: Embree
authors.forename: Paul
authors.initials: P
authors.lastname: Hazelton
authors.forename: Barbara
authors.initials: B
authors.lastname: Wells
authors.forename: R T Kevin
authors.initials: RT
authors.lastname: Coombs
mesh_terms: D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D007223:Infant; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid* / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D030102:Orthoreovirus, Mammalian / Q000302:isolation & purification*; D012088:Reoviridae Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D018570:Risk Assessment; D012720:Severity of Illness Index