Spectral pattern of total creatine and trimethyl ammonium in multiple sclerosis.
Fatigue and impairment mobility are frequent problems in multiple sclerosis (MS). Despite its enormous potential, in vivo (1)H MRS of skeletal muscles for MS patients is a largely unexplored field. One fundamental question remains unanswered: whether MS can cause observable proton metabolite changes. High quality two-dimensional in vivo (1)H MRS reveals that the spectral pattern of total creatine (tCr) and trimethyl ammonium (TMA) of soleus muscles of MS patients can be distinctively different from that of healthy volunteers, and in vivo (1)H MRS of skeletal muscles has a potential to become a useful tool in MS study.
Hu
Jiani
J
Department of Radiology, Wayne State University, Detroit, MI 48201, USA. jhu@med.wayne.edu
Xu
YingBiao
Y
Jiang
Quan
Q
Sehgal
Vivek
V
Shen
Yimin
Y
Xuan
Yang
Y
Xia
Yang
Y
D003401:Creatine / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*
D000644:Quaternary Ammonium Compounds; D003401:Creatine