Reversal of thymic atrophy.
Age-associated thymic atrophy is a key event preceding the inefficient functioning of the immune system, resulting in a diminished capacity to generate new T-cells. This thymic involution has been proposed to be due to changes in the thymic microenvironment resulting in its failure to support thymopoiesis. A key cytokine in the early stages of thymocyte development is IL-7 and expression levels are greatly reduced with age. The ability of IL-7 to restore the immune system by enhancing thymic output remains controversial. In this review, we highlight the advances in molecular approaches used to evaluate recent thymic emigrants and assess the success of these strategies in determining whether IL-7 can lead to immune reconstitution.
Henson
Sian M
SM
Department of Immunology, Imperial College, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK. s.henson@imperial.ac.uk
Pido-Lopez
Jeffrey
J
Aspinall
Richard
R
D000375:Aging / Q000276:immunology; D000818:Animals; D001284:Atrophy / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D015851:Interleukin-7 / Q000627:therapeutic use; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology*
D015851:Interleukin-7