title: Pigmented mammary Paget's disease mimicking melanoma.
abstract: Our case of pigmented mammary Paget's disease simulated melanoma clinically and dermoscopically. Histologically, the lesion was characterized by microscopic features similar to those seen in malignant melanoma and, to a lesser extent, in Bowen's disease (intra-epidermal squamous cell carcinoma). Immunohistochemical studies demonstrated that the tumor cells were positive for keratins (Cam 5.2+MNF 116) and AE1-AE3 and negative for HMB-45 and S-100 proteins. In conclusion clinical and dermoscopic examination cannot reliably distinguish melanoma from epithelial pre-neoplastic or neoplastic disease, therefore the differentiation of pigmented Paget's disease from superficial spreading of melanoma and Bowen's disease is based on histopathologic integrated with immunohistochemical criteria.
authors.affiliation: Division of Medical Oncology C, National Cancer Institute, Via Pademontana Occidentale 12, I-33081 Aviano, Italy.
authors.forename: Maria A
authors.initials: MA
authors.lastname: Pizzichetta
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Canzonieri
authors.forename: Samuele
authors.initials: S
authors.lastname: Massarut
authors.forename: Annunziata
authors.initials: A
authors.lastname: Gloghini
authors.forename: Giusto
authors.initials: G
authors.lastname: Trevisan
authors.forename: Andrea
authors.initials: A
authors.lastname: Veronesi
authors.forename: H Peter
authors.initials: HP
authors.lastname: Soyer
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology*; D010144:Paget's Disease, Mammary / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*
chemical_list: D007633:Keratins