Visualization of multiple genome annotations and alignments with the K-BROWSER.
We introduce a novel genome browser application, the K-BROWSER, that allows intuitive visualization of biological information across an arbitrary number of multiply aligned genomes. In particular, the K-BROWSER simultaneously displays an arbitrary number of genomes both through overlaid annotations and predictions that describe their respective characteristics, and through the multiple alignment that describes their global relationship to one another. The browsing environment has been designed to allow users seamless access to information available in every genome and, furthermore, to allow easy navigation within and between genomes. As of the date of publication, the K-BROWSER has been set up on the human, mouse, and rat genomes.
Chakrabarti
Kushal
K
Department of Computer Science, University of California, Berkeley, Berkeley, California 94720, USA.
Pachter
Lior
L
D000818:Animals; D019295:Computational Biology / Q000379:methods / Q000639:trends; D003196:Computer Graphics / Q000639:trends*; D017124:Conserved Sequence / Q000235:genetics; D016678:Genome; D015894:Genome, Human; D006801:Humans; D051379:Mice; D051381:Rats; D016415:Sequence Alignment / Q000379:methods* / Q000639:trends; D012689:Sequence Homology, Nucleic Acid; D012984:Software / Q000639:trends*