title: Depot local anesthetic in polymethylmethacrylate bone cement: a preliminary study.
abstract: Acrylic bone cement has been used successfully as a slow-release depot for antibiotics after orthopaedic surgery. The feasibility of administering local anesthetics in this way was examined in this preliminary in vitro study. Discs weighing approximately 4 g were prepared from five brands of acrylic cement (40 g) containing as much as 2 g of anesthetic base. Elution of the anesthetics into saline was measured during 72 hours. Prilocaine eluted the fastest and bupivacaine the slowest, with lidocaine between them. The elution rates were greatest in the first hour, declining thereafter. Rates also depended on the brand of cement with the quickest elution from CMW3 and the slowest from Surgical Simplex P. Using cement as a depot, therapeutic levels of a drug should be achievable in vivo at a negligible risk of toxicity. Before in vivo trials it is necessary to optimize elution of drugs in relation to the cement (brand, microstructure, method of preparation) and the concentration of a drug in the cement above which the cements' mechanical and adhesive properties are compromised.
authors.affiliation: Department of Anesthesiology, Queen's University, Kingston General Hospital, Ontario, Canada. dmbond@hotmail.com
authors.forename: David M
authors.initials: DM
authors.lastname: Bond
authors.forename: John
authors.initials: J
authors.lastname: Rudan
authors.forename: Susan M
authors.initials: SM
authors.lastname: Kobus
authors.forename: Michael A
authors.initials: MA
authors.lastname: Adams
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage*; D001843:Bone Cements; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005240:Feasibility Studies; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D001843:Bone Cements; D003692:Delayed-Action Preparations