Evans Blue and other dyes as protein tyrosine phosphatase inhibitors.
Commonly used dyes including Evans Blue and Trypan Blue were examined for their inhibitory activities against protein tyrosine phosphatases (PTPases), all of them showed inhibition of PTPases with different potencies. Of the 13 dyes tested, four exhibited IC(50) value of less than 10 microM, Evans Blue lowest IC(50) of 1.3 microM against PTP1B. Care must be taken in the use of dyes for clinical or biochemical experiments to avoid unwanted side effects. Some of the low molecular weight dyes might be useful as lead compounds for the development of potent and selective PTPase inhibitors.
Shrestha
Suja
S
Department of Chemistry and Institute of Molecular Cell Biology, Inha University, 253 Yonghyun-dong, Nam-ku, Incheon 402-751, South Korea.
Shim
Yi Sup
YS
Kim
Ki Chul
KC
Lee
Keun-Hyeung
KH
Cho
Hyeongjin
H
D004396:Coloring Agents / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005070:Evans Blue / Q000494:pharmacology*; D015394:Molecular Structure; D008970:Molecular Weight; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014343:Trypan Blue / Q000494:pharmacology
D004396:Coloring Agents; D004791:Enzyme Inhibitors; D005070:Evans Blue; D017027:Protein Tyrosine Phosphatases; D014343:Trypan Blue