title: The interleukin 1 receptor family.
abstract: Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region. The nature of this family of proteins and their signal transduction pathway is discussed in this review.
authors.affiliation: Sars International Centre for Marine Molecular Biology, High Technology Centre, Thormøhlensgt. 55, N-5008 Bergen, Norway.
authors.forename: Sumathi
authors.initials: S
authors.lastname: Subramaniam
authors.forename: Christine
authors.initials: C
authors.lastname: Stansberg
authors.forename: Charles
authors.initials: C
authors.lastname: Cunningham
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D053577:Interleukin-1 Receptor Accessory Protein; D000072179:Interleukin-1 Receptor-Like 1 Protein; D053727:Interleukin-18 Receptor alpha Subunit; D008562:Membrane Glycoproteins / Q000145:classification / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D018448:Models, Immunological; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D011506:Proteins / Q000145:classification / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000145:classification / Q000235:genetics / Q000502:physiology; D018123:Receptors, Interleukin / Q000235:genetics / Q000502:physiology; D017472:Receptors, Interleukin-1 / Q000145:classification / Q000235:genetics* / Q000502:physiology*; D053724:Receptors, Interleukin-18; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D051193:Toll-Like Receptors
chemical_list: C508572:IL18R1 protein, human; C507765:IL1RAP protein, human; C079241:IL1RL1 protein, human; D053577:Interleukin-1 Receptor Accessory Protein; D000072179:Interleukin-1 Receptor-Like 1 Protein; D053727:Interleukin-18 Receptor alpha Subunit; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D018123:Receptors, Interleukin; D017472:Receptors, Interleukin-1; D053724:Receptors, Interleukin-18; D051193:Toll-Like Receptors