title: Naphthalanotherapy reduces angiogenetic factor in psoriatic lesion.
abstract: Immunohistochemical analysis (cell immunophenotyping before and after 3 weeks of treatment with naphthalan oil) was performed on biopsy specimens from 10 patients with psoriasis vulgaris. To determine the angiogenetic factor in psoriatic lesions, immunohistochemical staining on 3-microm paraffin block sections was performed by using monoclonal anti-factor VIII antibody. There was a significant difference in the mean number of new blood vessels before and after the therapy (15.1 vs. 6.7). It seems that naphthalan therapy reduces number of new blood vessels and has effect on neovascularization in patients with psoriasis.
authors.affiliation: Naftalan Special Hospital for Medical Rehabilitation, 10310 Ivanić Grad, Croatia. jasna.lipozencic@zg.tel.hr
authors.forename: Pero
authors.initials: P
authors.lastname: Vrzogić
authors.forename: Jasminka
authors.initials: J
authors.lastname: Jakić-Razumović
authors.forename: Jasna
authors.initials: J
authors.lastname: Lipozencić
mesh_terms: D000287:Administration, Topical; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D001494:Baths; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011565:Psoriasis / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology
chemical_list: D020533:Angiogenesis Inhibitors; D009281:Naphthalenes; C043836:naphthalan