Membrane specializations and endosome maturation in dendritic cells and B cells.
Interest in the cell biology of antigen presentation is centered on dendritic cells (DCs) as initiators of the immune response. The ability to examine primary antigen-presenting cells, as opposed to cell lines, has opened a new window for study of antigen processing and peptide acquisition by Class II major histocompatibility complex (MHC) products, especially where intracellular trafficking of peptide-Class-II complexes is concerned. Here, we review the dynamics of Class II MHC-positive intracellular structures in dendritic cells as well as B cells. We focus on the generation of multivesicular bodies, where Class II MHC products acquire antigenic peptide, on the endosomal transport of peptide-loaded Class II MHC to the cell surface and on the importance of Class II MHC localization in membrane microdomains.
Boes
Marianne
M
Department of Pathology, Harvard Medical School, The New Research Building, Room 836, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Cuvillier
Armelle
A
Ploegh
Hidde
H
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002462:Cell Membrane / Q000378:metabolism*; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D011992:Endosomes / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000378:metabolism; D021381:Protein Transport / Q000276:immunology / Q000502:physiology
D000949:Histocompatibility Antigens Class II; D010455:Peptides