Differential influence of pentoxifylline on murine colon adenocarcinoma- and melanoma-derived metastatic tumor development in lungs.
Pentoxifylline (PTX), a methylxanthine derivative, is commonly and in most cases chronically used in patients suffering from peripheral vascular diseases. It increases erythrocyte flexibility, reduces blood viscosity and improves microcirculatory flow. Moreover, PTX has been found to enhance anticancer activity of some chemotherapeutic agents and ionizing irradiation. On the other hand, PTX has been recently shown to inhibit anticancer response and promote murine tumor growth in liver. In this study we show that PTX facilitates development of murine colon adenocarcinoma- but not melanoma-derived tumors also in lungs. It could suggest that tumor-promoting PTX activity is tissue-independent, although, it might depend on the cancer cell line.
Lazarczyk
Maciej
M
Department of Histology and Embryology, Center of Biostructure Research, The Medical University of Warsaw, PL 02 004 Warsaw, Poland. ml@plusnet.pl
Grzela
Tomasz
T
Niderla
Justyna
J
Lazarczyk
Marta Alicja
MA
Milewski
Lukasz
L
Dziunycz
Piotr
P
Skopinski
Piotr
P
Golab
Jakub
J
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010431:Pentoxifylline / Q000627:therapeutic use*; D023041:Xenograft Model Antitumor Assays
D010431:Pentoxifylline