[Determining the aortic and renal hemodynamic effects of propofol on rabbits using Doppler ultrasonography].
OBJECTIVE
The hemodynamic effects of propofol-fentanyl anesthesia were known to reduce arterial pressure and heart rate. We aimed to determine the effects of propofol-fentanyl anesthesia on renal artery blood flow and aorta by using Doppler ultrasonography on an animal model.


METHODS
The study was conducted on 8 male New Zaeland White strain rabbits. The initial aortic and renal hemodynamic measurements were determined on animals using ketamin anesthesia. Later the right femoral arteries were cannulated for determining arterial blood pressure and pulse oximetry was followed from the ear. Propofol 5-7 mg/kg with fentanyl 1-2 microg/kg was injected via the ear vein. Doppler parameters (RI, RI, Vmax, Vmin) of the renal artery and aorta were determined after the anesthesia.


RESULTS
According to the basal measurements, arterial blood pressure and breath rates declined significantly (27% and 53% respectively, p<0.05); however there were no statistical alteration of aortic and renal artery Doppler parameters.


CONCLUSIONS
Anesthesia induced by propofol-fentanyl did not induce a statistically significant difference in Doppler parameters obtained from the renal artery and aorta. It is clinically important to know that determining the changes in RI and PI during the postoperative period is not related to the propofol-fentanyl anesthesia.
Apan
Alpaslan
A
Kirikkale Universitesi Tip Fakültesi, Radyodiagnostik Anabilim Dali, Kirikkale, Turkey.
Karadeniz Bilgili
M Yasemin
MY
Cağlayan
Fatma
F
D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D001783:Blood Flow Velocity; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000098:blood supply*; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits / Q000502:physiology; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D018608:Ultrasonography, Doppler
D018686:Anesthetics, Intravenous; D005283:Fentanyl; D015742:Propofol