Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+.
Symmetrical homometallic dinuclear complexes of the type [(Ru(dpq)2)2(phen-SOS-phen)]4+, with a flexible 2-mercaptoethyl ether linker joining the two [Ru(dpq)2(phen)]2+-based sub-units, have DNA dissociation constants (Kd) in the nM range.
Aldrich-Wright
Janice
J
School of Science, Food and Horticulture, College of Science, Technology and Environment, University of Western Sydney, Penrith South, NSW 1797, Australia. J.Aldrich-Wright@uws.edu.au
Brodie
Craig
C
Glazer
Edith C
EC
Luedtke
Nathan W
NW
Elson-Schwab
Lev
L
Tor
Yitzhak
Y
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D015342:DNA Probes; D019281:Dimerization; D007364:Intercalating Agents / Q000737:chemistry*; D008024:Ligands; D008623:Mercaptoethanol / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D011810:Quinoxalines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013816:Thermodynamics
D015342:DNA Probes; D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D011725:Pyridines; D011743:Pyrimidines; D011810:Quinoxalines; D008623:Mercaptoethanol; D012428:Ruthenium; D004247:DNA