title: Anaplastic thyroid carcinoma with destructive thyrotoxicosis in a patient with preexisting multinodular goiter.
abstract: Presentation of anaplastic thyroid carcinoma with thyrotoxicosis is extremely rare and its occurrence in a patient with Wegener's granulomatosis has not been reported previously. We describe an elderly lady with Wegener's granulomatosis who developed a rapidly growing anaplastic thyroid carcinoma in a preexisting multinodular goiter and discuss the mechanism of thyrotoxicosis in this patient.
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Villa
authors.forename: J J
authors.initials: JJ
authors.lastname: Mukherjee
authors.forename: Nam Q
authors.initials: NQ
authors.lastname: Tran
authors.forename: W K
authors.initials: WK
authors.lastname: Cheah
authors.forename: H S
authors.initials: HS
authors.lastname: Howe
authors.forename: K O
authors.initials: KO
authors.lastname: Lee
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006044:Goiter, Nodular / Q000150:complications*; D014890:Granulomatosis with Polyangiitis / Q000150:complications; D006801:Humans; D013964:Thyroid Neoplasms / Q000150:complications*; D013971:Thyrotoxicosis / Q000209:etiology*