MTH-68/H oncolytic viral treatment in human high-grade gliomas.
Application of virus therapy to treat human neoplasms has over a three decade history. MTH-68/H, a live attenuated oncolytic viral strain of the Newcastle disease virus, is one of the viruses used in the treatment of different malignancies. Here we report on the administration of MTH-68/H to patients with glioblastoma multiforme, the most common and most aggressive neuroectodermal neoplasm with a poor prognosis, averaging six months to a year. Four cases of advanced high-grade glioma were treated with MTH-68/H after the conventional modalities of anti-neoplastic therapies had failed. This treatment resulted in survival rates of 5-9 years, with each patient still living today. Against all odds, each patient resumed a lifestyle that resembles their previous daily routines and enjoys a good quality of life, Each of these patients has regularly received MTH-68/H as their sole form of onco-therapy for a number of years now without interruption.
Csatary
L K
LK
United Cancer Research Institute, Alexandria, VA 22307, USA. UCRI@aol.com
Gosztonyi
G
G
Szeberenyi
J
J
Fabian
Z
Z
Liszka
V
V
Bodey
B
B
Csatary
C M
CM
D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002648:Child; D005260:Female; D005910:Glioma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009522:Newcastle disease virus / Q000276:immunology*; D011788:Quality of Life; D014765:Viral Vaccines / Q000627:therapeutic use*
C424862:Newcastle disease virus vaccine MTH-68-H; D014765:Viral Vaccines