Inner ear: Ca(2+)n you feel the noise?
The death of hair cells in the inner ear as a result of exposure to loud noise can lead to irreversible deafness. New work shows that the mammalian cochlea can sense noxious sounds and use Ca(2+) waves to rapidly propagate hair cell damage signals.
McDermott
Brian M
BM
Laboratory of Sensory Neuroscience, The Rockefeller University (314), 1230 York Avenue, New York, New York 10021, USA. mcdermb@rockefeller.edu
López-Schier
Hernán
H
D000255:Adenosine Triphosphate / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000293:injuries*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D009925:Organ of Corti / Q000378:metabolism* / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013016:Sound
D018048:Receptors, Purinergic P2; D015544:Inositol 1,4,5-Trisphosphate; D000255:Adenosine Triphosphate