[Effect of cigarette smoking on exhaled nitric oxide levels in healthy volunteers and patients with coronary heart disease].
Exhaled air contains nitric oxide in very low concentrations reaching several parts per billion. There are many factors which can influence exhaled nitric oxide levels (eNO), one of them is cigarette smoking.


METHODS
We investigated 78 patients: Group I (n = 26)--smokers, divided in two subgroups--I A healthy volunteers (n = 13) and I B--patients with coronary heart disease (CAD) (n = 13) Group II (n = 52)--nonsmokers. They were also divided in two subgroups--II A healthy volunteers (n = 21) and II B patients with CAD taking nitrates orally (n = 31) We use NO analyzer NOA 280 (Sievers Boulder Col. USA) with chemo-luminescence method


RESULTS
We found that eNO levels were significantly lower in smoking group than in nonsmokers. This fact was noticed in whole investigated population and in both subgroups,


CONCLUSIONS
1. Cigarette smoking significantly lowers exhaled nitric oxide levels and should be always taken into account during interpretation of the results. 2. Cigarette smoking significantly lowers exhaled nitric oxide levels even with of oral nitrates therapy.
Paweł
Nadziakiewicz
N
Oddział Kliniczny Kardioanestezji i Intensywnej Terapii Pooperacyjnej Slaskiej Akademii Medycznej, Slaskim Centrum Chorób Serca w Zabrzu.
Piotr
Knapik
K
Dariusz
Ziora
Z
Piotr
Rozentryt
R
D000284:Administration, Oral; D000328:Adult; D016022:Case-Control Studies; D003327:Coronary Disease / Q000378:metabolism*; D045853:Exhalation; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors
D009566:Nitrates; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase