title: A contemporary overview of peripheral nerve research from the Cleveland Clinic microsurgery laboratory.
abstract: Despite our better understanding of the pathophysiology of peripheral nervous system and advancements in microsurgical repair techniques, peripheral nerve injuries are still considered as a reconstructive challenge for all surgeons. For achieving a better nerve regeneration and better end organ reinnervation, advanced microsurgical manipulations are parallel with molecular biological discoveries. The field of peripheral nerve research is still developing and includes more sophisticated approach at the basic science level. In our Microsurgery Research Laboratory we have been working on different nerve repair techniques, including sleeve neurorrhaphy, sleeve grafts, single and polyfascicular nerve grafting techniques and studies on nerves in diabetic rats, in addition to the roles of different growth factors and pharmacological agents on peripheral nerve regeneration. New approaches for filling nerve gaps with nerve allografts and tolerance inducing strategies with their effect on nerve regeneration are included into our research armamentarium. In this overview we will summarize our 15-year experience in peripheral nerve research.
authors.affiliation: Department of Plastic Surgery, Cleveland Clinic Foundation, A-60, 9500 Euclid Avenue, Cleveland, OH 44195, USA. siemiom@ccf.org
authors.forename: Maria
authors.initials: M
authors.lastname: Siemionow
authors.forename: Alper
authors.initials: A
authors.lastname: Sari
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology / Q000627:therapeutic use; D019411:Clinical Laboratory Techniques / Q000379:methods* / Q000639:trends; D006801:Humans; D008866:Microsurgery / Q000379:methods* / Q000639:trends; D009820:Ohio; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000187:drug effects / Q000601:surgery* / Q000637:transplantation; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000601:surgery*; D012107:Research Design / Q000639:trends
chemical_list: D001672:Biocompatible Materials