Phagocytes: mechanisms of inflammation and tissue destruction.
Macrophages and neutrophils are the professional phagocytes of the innate immune system. Once in the inflammatory joint or the vasculitic lesion, macrophages and neutrophils contribute to the pathology observed. This article examines the mechanisms by which phagocytes contribute to the pathogenesis of these diseases.
Liu
Hongtao
H
Division of Rheumatology, Department of Medicine, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Ward 3-315, Chicago, IL 60611, USA.
Pope
Richard M
RM
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D010586:Phagocytes / Q000276:immunology* / Q000473:pathology; D013585:Synovitis / Q000276:immunology* / Q000473:pathology; D014657:Vasculitis / Q000276:immunology* / Q000473:pathology