A new alkaloid and its artificial derivative with an indazole ring from Nigella glandulifera.
A new compound, nigeglanine (1), and its new artificial derivative (1a), were isolated from the seeds of Nigella glandulifera, together with a known aporphine alkaloid, fuzitine (2). Their structures were established by spectral analysis, including two-dimensional (2D)-NMR spectroscopy. Nigeglanine (1) is the third natural product determined to contain an indazole nucleus.
Liu
Yu-Ming
YM
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haidian District, PR China.
Yang
Jun-Shan
JS
Liu
Qing-Hua
QH
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000302:isolation & purification; D007191:Indazoles / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D031844:Nigella / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
D000470:Alkaloids; D006575:Heterocyclic Compounds, 3-Ring; D007191:Indazoles; C493028:nigeglanine