[An association of apolipoprotein B with pulse pressure in Chinese pedigrees with familial combined hyperlipidemia].
OBJECTIVE
To investigate the influencing factors of blood pressure phenotypes and the distribution of FDH in FCHL families.


METHODS
Forty-two FCHL families with 435 members, 147 consanguine members and 90 members without consanguinity from Beijing area were studied. Eleven of the 42 FCHL families (26.2%) were identified as families with FDH syndrome. Stepwise regression analysis was used to analyze the association between the target variables and blood pressure phenotypes, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP), of the 237 FCHL members aged 30 to 60 years.


RESULTS
The prevalence of dyslipidemic hypertension in the FCHL relatives was significantly higher than that in the spouses (29.9% versus 8.9%, P < 0.01), with an odds ratio of 3.37 (95% CI 1.44 to 8.14). In the FCHL families body mass index (BMI), age and blood sugar were independent contributors to SBP, DBP, and MAP, respectively (all P < 0.05). Age and apolipoprotein B (apoB) were important contributors to pulse pressure (both P < 0.05).


CONCLUSIONS
BMI and glucose are significant contributors to different phenotypes of blood pressure. Moreover, apoB is a significant contributor to pulse pressure in FCHL families.
Pei
Wei-dong
WD
Fuwai Heart Hospital & Cardiovascular Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.
Sun
Yu-hua
YH
Zhang
Jian
J
Liu
Qun
Q
Jing
Zhi-cheng
ZC
Qiu
Da-yong
DY
Liu
Ya-hong
YH
Gong
Jing
J
Feng
Tian-jie
TJ
Lu
Zong-liang
ZL
Hui
Ru-tai
RT
Wu
Xi-gui
XG
Liu
Li-sheng
LS
D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D001794:Blood Pressure; D002681:China; D003241:Consanguinity; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010375:Pedigree; D010446:Peptide Fragments / Q000097:blood*; D010641:Phenotype; D012044:Regression Analysis; D012307:Risk Factors
D001055:Apolipoproteins B; D008055:Lipids; D010446:Peptide Fragments; C093007:apolipoprotein B (3304-3317)