title: An update on the pathogenesis and epidemiology of osteoarthritis.
abstract: Osteoarthritis is a disease affecting all joint structures, not just hyaline articular cartilage. It develops as a consequence of injurious activities acting on a vulnerable joint. The correlation between structural changes of the disease and joint symptoms is poor. Risk factors include age, obesity, and joint injury. Risk factors for symptoms include bone marrow edema, synovitis, and joint effusion.
authors.affiliation: Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 715 Albany Street, A203, Boston, MA 02118, USA. dfelson@bu.edu
authors.forename: David T
authors.initials: DT
authors.lastname: Felson
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001265:Athletic Injuries / Q000150:complications; D015519:Bone Density; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D009790:Occupations; D010003:Osteoarthritis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D015207:Osteoarthritis, Hip / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011859:Radiography; D012307:Risk Factors; D012737:Sex Factors