The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
In the following three sections we will briefly review the seminal roles of the HIV-1 nucleocapsid protein NCp7 in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase in the course of proviral DNA synthesis and to DNA integrity at the end of the polymerization process, and to the NC-assisted repair and recombination reactions fueling the viability and variability of the virus.
Bampi
Carole
C
LaboRetro, Unité de Virologie Humaine, INSERM #412, Ecole Normale supérieure de Lyon, 46 allee d'Italie, 69 364 Lyon, France.
Jacquenet
Sandrine
S
Lener
Daniela
D
Décimo
Didier
D
Darlix
Jean-Luc
JL
D036022:Capsid Proteins / Q000502:physiology*; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D004279:DNA, Viral / Q000096:biosynthesis* / Q000235:genetics; D015683:Gene Products, gag / Q000502:physiology*; D016679:Genome, Viral; D054303:HIV Reverse Transcriptase / Q000378:metabolism; D015497:HIV-1 / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D018832:Molecular Chaperones / Q000502:physiology*; D011533:Proviruses / Q000502:physiology*; D012367:RNA, Viral / Q000378:metabolism*; D011995:Recombination, Genetic; D014158:Transcription, Genetic; D014764:Viral Proteins; D014779:Virus Replication; D054301:gag Gene Products, Human Immunodeficiency Virus
D036022:Capsid Proteins; D018076:DNA, Complementary; D004279:DNA, Viral; D015683:Gene Products, gag; D018832:Molecular Chaperones; C071884:NCP7 protein, Human immunodeficiency virus 1; D012367:RNA, Viral; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; D054303:HIV Reverse Transcriptase