title: Prognostic factors in surgical stage I endometrial carcinoma.
abstract: The prognostic impact of DNA ploidy, MIB-1 and p53 was evaluated in relation to clinical and histopathological features in surgical stage I endometrial carcinoma (n = 284) and in the histopathological endometrioid subgroup (n = 257). Tumour material from 284 consecutive patients was analysed regarding image cytometric DNA ploidy and the immunohistochemical MIB-1 and p53 expression. Twenty-four tumours relapsed. In univariate analysis, histopathological subgroup (endometrioid vs. non-endometrioid), grade, DNA ploidy and p53 were highly significant prognostic factors (p < or = 0.001). MIB-1 was also significant (p = 0.039). In the endometrioid subgroup only DNA ploidy and p53 were significant (p < 0.001). In multivariate analysis of the entire material, ploidy and histopathological subgroup retained their significance (p = 0.001, p = 0.004), whereas only ploidy was significant in the endometrioid subgroup (p = 0.001). DNA ploidy was the strongest predictor of relapse-free survival and the only independent prognostic factor in the endometrioid subgroup.
authors.affiliation: Department of Gynaecologic Oncology, Radiumhemmet Karolinska University Hospital, Stockholm, Sweden. caroline.lundgren@ks.se
authors.forename: Caroline
authors.initials: C
authors.lastname: Lundgren
authors.forename: Gert
authors.initials: G
authors.lastname: Auer
authors.forename: Bo
authors.initials: B
authors.lastname: Frankendal
authors.forename: Bo
authors.initials: B
authors.lastname: Nilsson
authors.forename: Britta
authors.initials: B
authors.lastname: Nordström
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D002277:Carcinoma / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D004273:DNA, Neoplasm / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011003:Ploidies; D011336:Probability; D011379:Prognosis; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53