title: The biological activity in mammals and insects of the nucleosidic fraction from the spider Parawixia bistriata.
abstract: Previous work has shown that the crude venom of Parawixia bistriata induces convulsive seizures in rats after intracerebroventricular injection. In this work, the isolation of a bioactive fraction with ultraviolet absorption characteristics of nucleic acid and trace protein or amino acid content is described. NMR analysis demonstrated that the major component of the active fraction is the nucleoside inosine. An analogue of this component (inosine 5'-monophosphate) induced a delayed paralysis effect in termites.
authors.affiliation: Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto da, Universidade de São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, 14049-901 São Paulo, Brazil.
authors.forename: Marcelo Cairrão Araujo
authors.initials: MC
authors.lastname: Rodrigues
authors.forename: Renato
authors.initials: R
authors.lastname: Guizzo
authors.forename: Leonardo
authors.initials: L
authors.lastname: Gobbo-Neto
authors.forename: Richard John
authors.initials: RJ
authors.lastname: Ward
authors.forename: Norberto Peporine
authors.initials: NP
authors.lastname: Lopes
authors.forename: Wagner Ferreira
authors.initials: WF
authors.lastname: dos Santos
mesh_terms: D000818:Animals; D001681:Biological Assay; D007288:Inosine / Q000737:chemistry; D007291:Inosine Monophosphate / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D020049:Isoptera / Q000187:drug effects* / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013111:Spider Venoms / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D013112:Spiders / Q000737:chemistry*
chemical_list: D013111:Spider Venoms; D007291:Inosine Monophosphate; D007288:Inosine