Cloning and expression of human GTDC1 gene (glycosyltransferase-like domain containing 1) from human fetal library.
The glycosyltransferases (GTs) catalyze the synthesis of the carbohydrate portions of glycoproteins, glycolipids, and proteoglycans. Here we report the cloning and characterization of a novel human GTDC1 (glycosyltransferase-like domain containing 1) gene, which locates on human chromosome 2q22. The GTDC1 cDNA is 2954 bp in length, encoding a putative protein of 458 amino acids. At protein level human GTDC1 has 75 and 37% identity with its homologous counterparts in the mouse and fruitfly, respectively. RT-PCR analysis revealed its relatively high expression level in the adult lung, spleen, testis, and peripheral blood leukocyte.
Zhao
Enpeng
E
State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai 200433, PR China.
Li
Yao
Y
Fu
Xuping
X
Zhang
Jia-Yi
JY
Zeng
Huawu
H
Zeng
Li
L
Lin
Yun
Y
Chen
Jinzhong
J
Yin
Gang
G
Qian
Ji
J
Ying
Kang
K
Xie
Yi
Y
Zhao
Robert Chunhua
RC
Mao
Yu-Min
YM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D019295:Computational Biology; D016695:Glycosyltransferases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity
C484366:GTDC1 protein, human; D016695:Glycosyltransferases