Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease.
OBJECTIVE
To study the pathological characteristics of the mice with estrogen receptor beta (ER beta) disruption in brain.


METHODS
Immunohistochemistry method was applied in the study.


RESULTS
beta-Amyloid peptide(A beta (42)) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). A beta formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels.


CONCLUSIONS
ER beta is crucial to the development of neural degenerative disease, so modulation of A beta metabolism via ER beta signal pathway might be beneficial for AD prevention or therapy.
Zhang
Qing-hong
QH
Department of Physiology, Institute of Basic Medical Science,The Fourth Military Medical University, Xi-an 710032, Shaanxi, China. z_qinghong@hotmail.com
Huang
Yan-hong
YH
Hu
Yu-zhen
YZ
Wei
Gemg-ze
GZ
Han
Xue-feng
XF
Lu
Shun-yan
SY
Zhao
Yu-feng
YF
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000679:Amygdala / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000378:metabolism*; D047629:Estrogen Receptor beta; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D058225:Plaque, Amyloid / Q000473:pathology; D011960:Receptors, Estrogen / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen