Ductal carcinoma in situ of the breast, a population-based study of epidemiology and pathology.
In a population-based series of 2109 women with ductal carcinoma in situ (DCIS) diagnosed in 1995-2000 in New South Wales, Australia, incidence increased by an average of 5.5% a year, mostly between 1995 and 1996 and in women 50-69 years of age. This increase paralleled the increases in mammographic screening. BreastScreen NSW, an organised mammographic screening programme, detected 65% of all DCIS. High-grade lesions were 54% of all lesions and were more likely to be 2+ cm in diameter (OR=2.12, 95%CI 1.46-3.14) than low-grade lesions. In all, 40% of DCIS in women younger than 40 years was 2+ cm in diameter compared with 21% in women 40 years and older. Young age, high grade, mixed architecture and multifocality were significant and independent predictors of 2+ cm DCIS.
Kricker
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A
School of Public Health, Level 6, Medical Foundation Building K25, University of Sydney NSW 2006, Australia. annek@health.usyd.edu.au
Goumas
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C
Armstrong
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B
D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology*; D044584:Carcinoma, Ductal / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D008403:Mass Screening; D008875:Middle Aged; D009517:New South Wales; D012189:Retrospective Studies