title: [An association of apolipoprotein B with pulse pressure in Chinese pedigrees with familial combined hyperlipidemia].
abstract: OBJECTIVE
  To investigate the influencing factors of blood pressure phenotypes and the distribution of FDH in FCHL families.
  
  
  METHODS
  Forty-two FCHL families with 435 members, 147 consanguine members and 90 members without consanguinity from Beijing area were studied. Eleven of the 42 FCHL families (26.2%) were identified as families with FDH syndrome. Stepwise regression analysis was used to analyze the association between the target variables and blood pressure phenotypes, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP), of the 237 FCHL members aged 30 to 60 years.
  
  
  RESULTS
  The prevalence of dyslipidemic hypertension in the FCHL relatives was significantly higher than that in the spouses (29.9% versus 8.9%, P < 0.01), with an odds ratio of 3.37 (95% CI 1.44 to 8.14). In the FCHL families body mass index (BMI), age and blood sugar were independent contributors to SBP, DBP, and MAP, respectively (all P < 0.05). Age and apolipoprotein B (apoB) were important contributors to pulse pressure (both P < 0.05).
  
  
  CONCLUSIONS
  BMI and glucose are significant contributors to different phenotypes of blood pressure. Moreover, apoB is a significant contributor to pulse pressure in FCHL families.
authors.affiliation: Fuwai Heart Hospital & Cardiovascular Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Pei
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
authors.forename: Zhi-cheng
authors.initials: ZC
authors.lastname: Jing
authors.forename: Da-yong
authors.initials: DY
authors.lastname: Qiu
authors.forename: Ya-hong
authors.initials: YH
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Gong
authors.forename: Tian-jie
authors.initials: TJ
authors.lastname: Feng
authors.forename: Zong-liang
authors.initials: ZL
authors.lastname: Lu
authors.forename: Ru-tai
authors.initials: RT
authors.lastname: Hui
authors.forename: Xi-gui
authors.initials: XG
authors.lastname: Wu
authors.forename: Li-sheng
authors.initials: LS
authors.lastname: Liu
mesh_terms: D000328:Adult; D001055:Apolipoproteins B / Q000097:blood*; D001794:Blood Pressure; D002681:China; D003241:Consanguinity; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010375:Pedigree; D010446:Peptide Fragments / Q000097:blood*; D010641:Phenotype; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D001055:Apolipoproteins B; D008055:Lipids; D010446:Peptide Fragments; C093007:apolipoprotein B (3304-3317)