Surgery for esophageal carcinoma and the role of neoadjuvant therapy.
Esophagectomy is a major surgical procedure. Due to the related morbidity and mortality, this operation should be carried out in high-volume referral centers by expert surgeons. Only patients in whom a complete resection is predictable at preoperative staging can consistently benefit from the operation. Chemoradiation therapy should be the first-line approach in patients with locally advanced tumors. A pathological complete response to neoadjuvant therapy is associated with a significantly improved long-term survival.
Bonavina
Luigi
L
Department of Medical and Surgical Sciences, Division of General Surgery, Istituto Policlinico San Donato, University of Milan. luigi.bonavina@unimi.it
Bona
Davide
D
Luporini
Alberto
A
Navoni
Nicoletta
N
Zucali
Roberto
R
D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D008197:Lymph Node Excision; D020360:Neoadjuvant Therapy