title: [Laryngeal symptoms in patients with gastroesophageal reflux diseases].
abstract: Gastroesophageal reflux disease (GERD) is considered an important etiological factor of numerous larynx dysfunctions. The goal of our study was to describe larynx status of patients with GERD before and after treatment. Forty-five patients with GERD symptoms entered our study. GERD was confirmed in 24-hours pH-metric examination. Patients were treated with proton pump inhibitors in doses chosen accordingly to GERD severity. All patients underwent endoscopic evaluation of the larynx and acoustic voice analysis before and after the treatment. GERD was diagnosed in 35 out of 45 patients. Acoustic voice analysis revealed that voice disorders appeared more often in patients with severe than moderate or mild refluxes (p = 0.023). Laryngeal changes found in endoscopic evaluation also depended on reflux severity (p = 0.05). The voice quality improved (p = 0.031) and the changes in larynx diminished after anti-reflux treatment (p = 0.016).
authors.affiliation: Katedra i Klinika Otolaryngologii AM we Wrocławiu. krecicki@orl.am.wroc.pl
authors.forename: Maria
authors.initials: M
authors.lastname: Zalesska-Krecicka
authors.forename: Dorota
authors.initials: D
authors.lastname: Waśko-Czopnik
authors.forename: Tomasz
authors.initials: T
authors.lastname: Krecicki
authors.forename: Leszek
authors.initials: L
authors.lastname: Paradowski
authors.forename: Maciej
authors.initials: M
authors.lastname: Zatoński
authors.forename: Monika
authors.initials: M
authors.lastname: Horobiowska
mesh_terms: D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007818:Laryngeal Diseases / Q000188:drug therapy* / Q000209:etiology*; D007828:Laryngoscopy; D008297:Male; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000627:therapeutic use; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D054328:Proton Pump Inhibitors; D017494:Proton Pumps