title: [Automatic extraction of corpus callosum from midsagittal head MR image and examination of Alzheimer-type dementia objective diagnostic system in feature analysis].
abstract: We studied the objective diagnosis of Alzheimer-type dementia based on changes in the corpus callosum. We examined midsagittal head MR images of 40 Alzheimer-type dementia patients (15 men and 25 women; mean age, 75.4+/-5.5 years) and 31 healthy elderly persons (10 men and 21 women; mean age, 73.4+/-7.5 years), 71 subjects altogether. First, the corpus callosum was automatically extracted from midsagittal head MR images. Next, Alzheimer-type dementia was compared with the healthy elderly individuals using the features of shape factor and six features of Co-occurrence Matrix from the corpus callosum. Automatic extraction of the corpus callosum succeeded in 64 of 71 individuals, for an extraction rate of 90.1%. A statistically significant difference was found in 7 of the 9 features between Alzheimer-type dementia patients and the healthy elderly adults. Discriminant analysis using the 7 features demonstrated a sensitivity rate of 82.4%, specificity of 89.3%, and overall accuracy of 85.5%. These results indicated the possibility of an objective diagnostic system for Alzheimer-type dementia using feature analysis based on change in the corpus callosum.
authors.affiliation: Graduate School of Engineering, Nagaoka University of Technology.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kaneko
authors.forename: Naoki
authors.initials: N
authors.lastname: Kodama
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Kaeriyama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawase
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibukawa
authors.forename: Ichiro
authors.initials: I
authors.lastname: Fukumoto
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012680:Sensitivity and Specificity