[The expression of trefoil factor 1 and trefoil factor 2 in gastric cancer and precancer].
OBJECTIVE
Trefoil factor 1 (TFF1) and trefoil factor 2 (TFF2) are members of the trefoil peptide family. To investigate the relationship between TFF1, TFF2 and tumorigenesis of precancerous conditions and gastric cancer.


METHODS
The expression of TFF1, TFF2 was determined by immunohistochemical method in 140 gastric specimens including 35 chronic superficial gastritis (CSG), 35 gastric ulcer (GU), 35 chronic atrophic gastritis (CAG) and 35 gastric cancer (GC).


RESULTS
In the CSG, GU, CAG and GC, the level of TFF1 expression had a decreasing tendency (P < 0.05). The expression of TFF2 also had a decreased tendency in GU, CAG, and GC (P < 0.05).


CONCLUSIONS
The reducing expression of TFF1, TFF2 in the precancerous conditions and gastric cancer was confirmed, and the decrease of TFF1, TFF2 expression may be related to tumorigenesis, progression and the degree of tumor differentiation. Further studies will be necessary to determine the mechanisms of TFF1, TFF2 in the tumor and prospects of clinical implication.
Shi
Shu-qing
SQ
Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. shishuqing@263.net
Cai
Jian-ting
JT
D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides / Q000032:analysis*; D011230:Precancerous Conditions / Q000737:chemistry* / Q000209:etiology; D011506:Proteins / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000209:etiology; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins
D009077:Mucins; D009124:Muscle Proteins; D009479:Neuropeptides; D010455:Peptides; D011506:Proteins; C051838:TFF1 protein, human; C000604007:TFF2 protein, human; C099037:TFF3 protein, rat; C000604008:Tff2 protein, rat; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins