title: Epigenetic regulation of tumor suppressors in t(8:21)-containing AML.
abstract: The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine, PRB 512, 23rd and Pierce, Nashville, Tennessee 37232, USA.
authors.forename: Genyan
authors.initials: G
authors.lastname: Yang
authors.forename: Waleed
authors.initials: W
authors.lastname: Khalaf
authors.forename: Louis
authors.initials: L
authors.lastname: van de Locht
authors.forename: Joop H
authors.initials: JH
authors.lastname: Jansen
authors.forename: Bert A
authors.initials: BA
authors.lastname: van der Reijden
authors.forename: Carsten
authors.initials: C
authors.lastname: Müller-Tidow
authors.forename: H Ruud
authors.initials: HR
authors.lastname: Delwel
authors.forename: Hubert
authors.initials: H
authors.lastname: Serve
authors.forename: D Wade
authors.initials: DW
authors.lastname: Clapp
authors.forename: Scott W
authors.initials: SW
authors.lastname: Hiebert
mesh_terms: D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D000075142:RUNX1 Translocation Partner 1 Protein; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic; D014178:Translocation, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D000075142:RUNX1 Translocation Partner 1 Protein; C493728:RUNX1 protein, human; C082222:RUNX1T1 protein, human; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D018631:ras Proteins