Time-frequency analysis of laser Doppler flowmetry signals recorded in response to a progressive pressure applied locally on anaesthetized healthy rats.
The laser Doppler flowmetry technique has recently been used to report a significant transient increase of the cutaneous blood flow signal, in response to a local non-noxious pressure applied progressively on the skin of both healthy humans and rats. This phenomenon is not entirely understood yet. In the present work, a time-frequency analysis is applied to signals recorded on anaesthetized healthy rats, at rest and during a cutaneous pressure-induced vasodilation (PIV). The comparison, at rest and during PIV, of the scalogram relative energies and scalogram relative amplitudes in five bands, corresponding to five characteristic frequencies, shows an increased contribution for the endothelial related metabolic activity in PIV signals, till 400 s after the beginning of the progressive pressure application. The other subsystems (heart, respiration, myogenic and neurogenic activities) contribute relatively less during PIV than at rest. The differences are statistically significant for all the relative activities in the interval 0-200 s following the beginning of the pressure. These results and others obtained on patients, such as diabetics, could increase the understanding of some cutaneous pathologies involved in various neurological diseases and in the pathophysiology of decubitus ulcers.
Humeau
Anne
A
Groupe ISAIP-ESAIP, 18 rue du 8 mai 1945, BP 80022, 49180 Saint Barthelemy d'Anjou Cedex, France. ahumeau@isaip.uco.fr
Koïtka
Audrey
A
Abraham
Pierre
P
Saumet
Jean-Louis
JL
L'Huillier
Jean-Pierre
JP
D000779:Anesthetics, Local / Q000627:therapeutic use*; D000818:Animals; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D015233:Models, Statistical; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D012867:Skin / Q000473:pathology; D012984:Software; D013997:Time Factors; D014664:Vasodilation
D000779:Anesthetics, Local