title: Early aseptic loosening of cemented total hip arthroplasty: the influence of non-steroidal anti-inflammatory drugs and smoking.
abstract: The purpose of this study was to investigate whether the clinical variables of non-steroidal anti-inflammatory drugs (NSAID) usage and cigarette smoking are possibly linked to aseptic loosening around total hip arthroplasty (THA). We performed a retrospective review of the records and radiographs of 224 patients attending for follow-up at Wrightington Hospital between August 2002 and 2003 who had undergone THA. The following information was recorded: age, gender, primary and revision surgery details, radiographic parameters, smoking history and NSAID usage history. Logistic regression analysis was used to determine if there is any statistically significant association between NSAID usage or smoking habit and aseptic loosening. No such association was found.
authors.affiliation: Centre for Hip Surgery, Wrightington Hospital, Hall Lane, WN6 9EP, Appley Bridge, Wigan, UK. hammymalik@hotmail.com
authors.forename: M H A
authors.initials: MH
authors.lastname: Malik
authors.forename: J
authors.initials: J
authors.lastname: Gray
authors.forename: P R
authors.initials: PR
authors.lastname: Kay
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002484:Cementation; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D016015:Logistic Models; D008297:Male; D011475:Prosthesis Failure; D012189:Retrospective Studies; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal