Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development.
We have characterized for the first time the mouse expression patterns of the three known members of the novel RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C) by in situ hybridization. Both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system. During development, both RGM A and B appear also in lung and in limb cartilage, while RGM B has additional expression domains in pancreas.
Oldekamp
Judit
J
Max-Planck-Institute, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Krämer
Nadine
N
Alvarez-Bolado
Gonzalo
G
Skutella
Thomas
T
D000818:Animals; D002356:Cartilage / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal; D058851:GPI-Linked Proteins; D017403:In Situ Hybridization; D008168:Lung / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D051379:Mice / Q000196:embryology* / Q000254:growth & development* / Q000378:metabolism; D009124:Muscle Proteins / Q000096:biosynthesis* / Q000235:genetics; D018482:Muscle, Skeletal / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009420:Nervous System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D010179:Pancreas / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D000071020:Hemochromatosis Protein
D015816:Cell Adhesion Molecules, Neuronal; D058851:GPI-Linked Proteins; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; C483496:Rgma protein, mouse; C483497:Rgmb protein, mouse; C504414:HJV protein, mouse; D000071020:Hemochromatosis Protein