title: [A case of advanced gastric cancer with DIC treated by sequential MTX and 5-FU].
abstract: A 75-year-old man was admitted to our hospital complaining of gastric fatigue. Endoscope and CT scan revealed type 3 gastric cancer with paraaortic lymph nodal metastasis. Histological examination of the endoscopic biopsy revealed poorly differentiated adenocarcinoma. A blood examination and bone marrow biopsy revealed DIC causing bone marrow carcinosis. Chemotherapy with sequential therapy consisting of MTX and 5-FU was performed. Stretch of the fold and flatness of the ulcer were obtained against the gastric primary lesion observed endoscopically. Complete response was obtained against the lymph node around the abdominal aorta. Reduction of low back pain and DIC were observed. He was thus able to be discharged and sequential therapy was performed again over 2 months in outpatient care.
authors.affiliation: Second Dept. of Internal Medicine, Osaka Medical College.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ohta
authors.forename: Hiroya
authors.initials: H
authors.lastname: Takiuchi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kawabe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Gotoh
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hirata
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Katsu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hongo
authors.forename: Keigo
authors.initials: K
authors.lastname: Fujita
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
chemical_list: D005472:Fluorouracil; D008727:Methotrexate