title: Oral paracoccidioidomycosis or squamous cell carcinoma?
abstract: Paracoccidioidomycosis is a deep, systemic, and progressive mycosis caused by Paracoccidioides brasiliensis. Oral lesions normally are multiples with a mulberry-like appearance. This article reviews an unusual case involving a chronic, solitary, and ulcerated lesion whose clinical aspects were similar to squamous cell carcinoma. Viewed microscopically, the lesion showed pseudoepitheliomatous hyperplasia and non-necrotizing granulomas. The patient was treated with systemic ketoconazole. Over the next 11 years, follow-up examinations were performed but no recurrence was observed.
authors.affiliation: Department of Oral Diagnosis, Dental School, University of Campinas, Piracicaba-SP, Brazil.
authors.forename: Estela
authors.initials: E
authors.lastname: Kaminagakura
authors.forename: Edgard
authors.initials: E
authors.lastname: Graner
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: de Almeida
authors.forename: Osvaldo
authors.initials: O
authors.lastname: Di Hipolito Júnior
authors.forename: Marcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000382:microbiology*; D009062:Mouth Neoplasms / Q000175:diagnosis*; D019226:Oral Ulcer / Q000175:diagnosis / Q000382:microbiology; D010229:Paracoccidioidomycosis / Q000175:diagnosis*
chemical_list: D000935:Antifungal Agents; D007654:Ketoconazole