title: Coeliac disease in Iranian type I diabetic patients.
abstract: BACKGROUND
  The association between coeliac disease and type I diabetes mellitus has been evaluated in some previous studies, but its prevalence in Iranian diabetic patients remains unknown.
  
  
  OBJECTIVE
  To evaluate the prevalence of coeliac disease in patients with type I diabetes mellitus in Iran.
  
  
  METHODS
  A total of 250 consecutive patients (102 male and 148 female) with type I diabetes mellitus.
  
  
  METHODS
  Total serum immunoglobulin A level and immunoglobulin A endomysial antibody was measured for all patients. Endoscopy and biopsy of the duodenum were performed for immunoglobulin A endomysial antibody-positive patients and pathologic evaluation was done according to modified Marsh classification.
  
  
  RESULTS
  The mean age of the patients was 18.7 years (range: 2-55 years). Total serum immunoglobulin A was in the normal range for all patients. Immunoglobulin A endomysial antibody was positive in six (2.4%) patients (all of them were females; P = 0.04). Duodenal biopsy samples revealed grade I in two patients, grade II in three patients and grade IIIb in one patient (modified Marsh classification). Patients with coeliac disease and diabetes mellitus were older than patients with diabetes mellitus alone (mean age: 29.5 years versus 18.4 years; P < 0.001). There was a trend for longer duration of diabetes mellitus in coeliac patients than in patients without it (mean age: 17.3 years versus 12.5 years; P = 0.16).
  
  
  CONCLUSIONS
  The prevalence of coeliac disease in Iranian patients with type I diabetes mellitus is relatively high (2.4%). Since almost half of the patients with coeliac disease are asymptomatic, all patients with type I diabetes mellitus should be screened for coeliac disease regardless of the presence of symptoms, at diagnosis of diabetes mellitus and with regular intervals in the follow up.
authors.affiliation: Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, North Kargar Avenue, Tehran 14114, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Shahbazkhani
authors.forename: T
authors.initials: T
authors.lastname: Faezi
authors.forename: M R
authors.initials: MR
authors.lastname: Akbari
authors.forename: M
authors.initials: M
authors.lastname: Mohamadnejad
authors.forename: M
authors.initials: M
authors.lastname: Sotoudeh
authors.forename: A
authors.initials: A
authors.lastname: Rajab
authors.forename: S
authors.initials: S
authors.lastname: Tahaghoghi
authors.forename: R
authors.initials: R
authors.lastname: Malekzadeh
mesh_terms: D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D007070:Immunoglobulin A