Footprints of atherosclerotic coronary heart disease in children.
Formerly viewed as a bland lipid storage disease mainly affecting adults, atherosclerosis is nowadays recognized to be a chronic inflammatory disease that begins much earlier, probably already during fetal life. There has inevitably been reorientation from the traditional risk factor cholesterol to a broad category of factors, including those triggering chronic inflammation, such as infections. In addition, major advances in the field of vascular biology have led to a reassessment of our perception and understanding of the pathogenesis of atherosclerosis. A key role in this process is now attributed to vascular endothelium.
Personen
Erkki
E
Division of Pediatric Cardiology, Department of Pediatrics University Hospital, Lund, Sweden.
Liuba
Petru
P
D000208:Acute Disease; D000789:Angina, Unstable / Q000150:complications; D001161:Arteriosclerosis / Q000150:complications / Q000517:prevention & control; D002648:Child; D003324:Coronary Artery Disease / Q000209:etiology / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D006801:Humans; D007239:Infections / Q000150:complications; D009203:Myocardial Infarction / Q000150:complications; D013577:Syndrome