To live or die by the sword: the regulation of apoptosis by the proteasome.
The proteasome has been implicated in the control of apoptosis by modulating the levels of both pro- and antiapoptotic molecules. A recent study published in the April 9th issue of Molecular Cell reveals that caspase-dependent inactivation of the proteasome can amplify the activation of apoptosis.
Friedman
Josh
J
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Xue
Ding
D
D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D015398:Signal Transduction / Q000502:physiology; D025801:Ubiquitin / Q000378:metabolism
D009097:Multienzyme Complexes; D025801:Ubiquitin; D010447:Peptide Hydrolases; D020169:Caspases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex