title: Cortisol and estradiol secretion by a benign virilizing adrenocortical tumor in a prepubertal girl.
abstract: We report a 5.5 year-old girl with a benign adrenocortical adenoma who presented with virilization and rapid growth. She did not have any clinical features of isosexual precocity or, except for hypertension, Cushing's syndrome. Measurement of hormones in adrenal vein blood obtained at surgery showed high concentrations of testosterone, cortisol, estradiol and intermediary substrates. Elevated levels of hormones detected in the peripheral blood were released directly from the tumor and were not the result of peripheral interconversion. Hyperandrogenism can obscure the clinical features of Cushing's syndrome and estrogen hypersecretion in patients with functional adrenal tumors.
authors.affiliation: Endocrine Research Center and Department of Internal Medicine, Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
authors.forename: Ali A M
authors.initials: AA
authors.lastname: Ghazi
authors.forename: Djafar
authors.initials: D
authors.lastname: Mofid
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Rahimi
authors.forename: Ab
authors.initials: A
authors.lastname: Sadeghi-Nejad
mesh_terms: D000152:Acne Vulgaris / Q000209:etiology; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D002675:Child, Preschool; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006728:Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D006973:Hypertension / Q000503:physiopathology; D011629:Puberty, Precocious / Q000209:etiology
chemical_list: D006728:Hormones; D004958:Estradiol; D006854:Hydrocortisone