Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA.
To determine whether the adenosine A2A receptor might play a role in L-DOPA-induced dyskinesia in Parkinson's disease, we analyzed changes in the expression of A2A receptor mRNA in response to intermittent treatment with L-DOPA in rats with dopaminergic denervation by 6-hydroxydopamine (OHDA) infusion into the medial forebrain bundle. Intermittent treatment with L-DOPA increased A2A receptor mRNA levels in the dopamine-depleted striatum of 6-OHDA-lesioned rats exhibiting behavioral sensitization to L-DOPA. These results suggest that A2A receptor activation is associated with the development of motor complications induced by L-DOPA treatment.
Tomiyama
Masahiko
M
Third Department of Medicine, Hirosaki University School of Medicine, Hirosaki 036-8216, Japan. tomiyama@cc.hirosaki-u.ac.jp
Kimura
Tamaki
T
Maeda
Tetsuya
T
Tanaka
Hiroyasu
H
Kannari
Kazuya
K
Baba
Masayuki
M
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001345:Autoradiography; D015259:Dopamine Agents / Q000494:pharmacology*; D018491:Dopamine Agonists / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000188:drug therapy; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D043705:Receptor, Adenosine A2A / Q000096:biosynthesis*; D013239:Stereotyped Behavior / Q000187:drug effects; D013563:Sympathectomy, Chemical; D013565:Sympatholytics; D015854:Up-Regulation / Q000187:drug effects
D015259:Dopamine Agents; D018491:Dopamine Agonists; D012333:RNA, Messenger; D043705:Receptor, Adenosine A2A; D013565:Sympatholytics; D007980:Levodopa; D016627:Oxidopamine; D001058:Apomorphine