[Selection of an extraction agent and development of the technology for producing an extract with sedative effects].
The drugs Valerinae radix, Crataegi fructus, Leonuri herba and Melissae folium were used to produce a liquid plant extract. The experiment revealed that the extraction with 70% ethanol achieved the highest concentration of extractable active principles. The optimal conditions for obtaining a sedative extract are established when the method of repercolation is used, and in the production itself the batch of the drug is divided into equally large doses and a pre-prepared mixture of plant drugs is extracted. The extract prepared by this manner remains stable for the whole period of storage, i.e., 24 months.
Savickas
A
A
Katedra technologie léků a OF Farmaceutické fakulty Kaunasské univerzity medicíny, Kaunas, Litevská republika.
Ramanauskiene
K
K
Savickiene
N
N
Kazlauskas
S
S
Masteiková
R
R
Chalupová
Z
Z
D002626:Chemistry, Pharmaceutical / Q000379:methods; D006993:Hypnotics and Sedatives / Q000302:isolation & purification*; D010936:Plant Extracts / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*
D006993:Hypnotics and Sedatives; D010936:Plant Extracts