title: Dietary protein modulates the effect of CLA on lipid metabolism in rats.
abstract: The effect of the interaction of CLA and type of dietary protein on lipid metabolism was studied in male rats by feeding diets containing casein (CAS) or soy protein (SOY) as dietary protein and either linoleic acid (LA, a control FA) or graded levels of CLA at 0, 0.1, 0.5, and 1.0% for 28 d. CLA reduced the weight of perirenal adipose tissue in a dose-dependent manner, but the magnitude of the reduction was greater when rats were fed SOY. Feeding SOY resulted in a significant reduction of the concentrations of serum total and HDL cholesterol, TG, glucose, and insulin irrespective of dietary CLA. The concentration of serum leptin tended to be lower on the SOY diet free of CLA than in the corresponding CAS diet, but it fell with an increasing dietary level of CLA in the CAS groups. In contrast, serum leptin tended to increase when CLA was added to SOY diets. The concentration of serum adiponectin was higher in the CAS than in the SOY groups, and it tended to increase in response to dietary CLA levels in the CAS-fed rats, whereas CLA showed no effect in SOY-fed rats. The activity of liver mitochondrial carnitine palmitoyltransferase was higher in the SOY than in the CAS groups, but it tended to increase with an increasing dietary level of CLA in both protein groups. Although the body fat-reducing activity of CLA was more effective when the protein source was SOY, rats fed CAS appeared to be more susceptible to CLA than in those fed SOY with respect to cytokines examined. These results suggest that the type of dietary protein may modify the antiobesity activity of CLA.
authors.affiliation: Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto 862-8502, Japan. a-asuka@pu-kumamoto.ac.jp
authors.forename: Asuka
authors.initials: A
authors.lastname: Akahoshi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Koba
authors.forename: Fumika
authors.initials: F
authors.lastname: Ichinose
authors.forename: Mai
authors.initials: M
authors.lastname: Kaneko
authors.forename: Asako
authors.initials: A
authors.lastname: Shimoda
authors.forename: Kikuko
authors.initials: K
authors.lastname: Nonaka
authors.forename: Masao
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Toshio
authors.initials: T
authors.lastname: Iwata
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Michihiro
authors.initials: M
authors.lastname: Sugano
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006128:Growth / Q000187:drug effects; D019787:Linoleic Acid / Q000008:administration & dosage / Q000378:metabolism*; D050356:Lipid Metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D030262:Soybean Proteins / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D002364:Caseins; D004044:Dietary Proteins; D030262:Soybean Proteins; D019787:Linoleic Acid