[Postoperative adhesions following para-aortic lymphadenectomy by laparotomy with as compared to without Intergel. Experimental animal study].
BACKGROUND
Advanced cancers of the cervix are treated by external radiotherapy within range limits which depend on the para-aortic ganglion metastases found during surgical staging. The presence of postoperative intraperitoneal adhesions increases the risk of postradical enteritis. The aim of this study is to investigate the efficacy of an anti-adhesive substance (Intergel) undergoing para-aortic lymphadenectomy by laparotomy.


METHODS
We conduced a prospective, randomized study on 60 pigs divided into 2 groups (with and without Intergel) undergoing para-aortic lymphadenectomy by laparotomy to compare the efficacy of an anti-adhesive substance using an adhesion scoring system based on density and surface area in question.


RESULTS
There was no difference between the 2 groups in terms of duration of surgery, number of ganglia removed, postoperative mortality and per and postoperative morbidity, especially the adhesion process.


CONCLUSIONS
Administration of an anti-adhesive substance such as Intergel does not reduce the adhesion process after para-aortic lymphadenectomy in animals. However, perhaps we can not interpret these results because of the too much quantity of anti-adhesive substance for the animal weight, and because of the too precocious control.
Occelli
B
B
Service de Chirurgie Gynécologique, Hôpital de Valenciennes, avenue de Monaco, BP 479, 59322 Valenciennes Cedex. occelli-b@ch-valenciennes.fr
Zafrani
Y
Y
Narducci
F
F
Bigotte
A
A
Leblanc
E
E
Querleu
D
D
D000818:Animals; D001011:Aorta; D004195:Disease Models, Animal; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D010535:Laparoscopy; D008197:Lymph Node Excision / Q000295:instrumentation* / Q000379:methods*; D009017:Morbidity; D010532:Peritoneal Diseases / Q000453:epidemiology* / Q000517:prevention & control; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control; D011446:Prospective Studies; D011897:Random Allocation; D013552:Swine; D000267:Tissue Adhesions / Q000453:epidemiology / Q000517:prevention & control; D016896:Treatment Outcome
D006820:Hyaluronic Acid