N-myc transcription molecule and oncoprotein.
N-myc has emerged as a member of a transcriptional regulatory network which impinges directly on the machinery of cell growth and proliferation. Critical during neural crest embryogenesis, N-myc is rapidly down-regulated as tissues become terminally differentiated and growth-arrested. The involvement of N-myc in these fundamental cellular processes necessitates an intricate strategy for its regulation, which is still being elucidated. Deregulated N-myc over-expression has clear transforming ability in vitro and in vivo. The transcriptional target genes responsible for this activity are beginning to be unravelled.
Thomas
Wayne D
WD
Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia. wthomas@ccia.org.au
Raif
Anna
A
Hansford
Loen
L
Marshall
Glenn
G
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D051379:Mice; D009432:Neural Crest / Q000196:embryology; D017434:Protein Structure, Tertiary / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use
D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors