Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits.
BACKGROUND
The present study was planned to observe the hypoglycemic effect of the 'Ficus relegiosa', a traditional medicinal plant. This study was performed to study the possible role of indigenous medicinal plants in the treatment of Diabetes mellitus (type-2)


METHODS
Normal rabbits were divided into 5 groups (1-5) of six animals each. Group I served as control and received 15 ml of water only. Group 2 received tolbutamide 500-mg/Kg body weight. Group 3-5 received the extract of Ficus relegiosa dissolved in 15 ml of water in doses of 200 mg/Kg. 250 mg/Kg and 300 mg/Kg body weight respectively. The diabetic rabbits were also divided in 5 groups on the same pattern. The blood glucose and total lipid levels were estimated before and 1, 2, 3 and 4 hours after the administration of the extract.


RESULTS
The extract exerted a significant (P < 0.05) hypoglycemic effect in normal rabbits, which was however short lived. The hypoglycemic effect was not significant (P > 0.05) in alloxan treated rabbits. The extract had no significant effect (P > 0.05) on total lipid levels in normal as well as in alloxan-treated diabetic rabbits. The doses used did not show acute toxicity or result in behavioral changes.


CONCLUSIONS
From this study it may be concluded that the extract acts by initiating the release of insulin by pancreatic beta cells of normal rabbits.
Wadood
Noreen
N
Department of Pharmacology & Therapeutics, Khyber Medical College, Peshawar.
Wadood
Abdul
A
Nisar
Mohammed
M
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D011817:Rabbits; D014044:Tolbutamide / Q000494:pharmacology; D027003:Urticaceae
D001786:Blood Glucose; D008055:Lipids; D010936:Plant Extracts; D014044:Tolbutamide