title: [Hereditary deafness: molecular genetics].
abstract: This article outlines recent advances in explaining hereditary deafness in molecular terms, focusing on isolated (i.e. nonsyndromic) hearing loss. The number of genes identified (36 to date) is growing rapidly. However, difficulties inherent in genetic linkage analysis, coupled with the possible involvement of environmental causes, have so far prevented the characterization of the main genes causative or predisposing to the late-onset forms of deafness.
authors.affiliation: Unité de génétique des déficits sensoriels, Inserm U.587, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hardelin
authors.forename: Françoise
authors.initials: F
authors.lastname: Denoyelle
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Levilliers
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Simmler
authors.forename: Christine
authors.initials: C
authors.lastname: Petit
mesh_terms: D017668:Age of Onset; D003638:Deafness / Q000235:genetics*; D004777:Environment; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans