Detection of polymorphisms in the prion protein gene in the Belgian sheep population: some preliminary data.
The development of clinical signs of TSE/scrapie in sheep has been linked to polymorphisms in the prion protein (PRNP) gene. The most important polymorphisms appear to be at codons 136, 154, and 171. The objective of this study was to investigate the polymorphisms at these codons in the Belgian sheep population, including clinical healthy animals, healthy animals at the slaughterhouse and animals in TSE/scrapie positive farms (including a Nor98 farm).
Roels
S
S
National Reference Laboratory for Veterinary TSE, Department of Biocontrol Veterinary and Agrochemical Research Centre (CODA/CERVA), Brussels, Belgium. stroe@var.fgov.be
Renard
C
C
De Bosschere
H
H
Geeroms
R
R
Van Poucke
M
M
Peelman
L
L
Vanopdenbosch
E
E
D000818:Animals; D001530:Belgium / Q000453:epidemiology; D005838:Genotype; D011110:Polymorphism, Genetic; D011328:Prions / Q000235:genetics*; D012608:Scrapie / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D012756:Sheep
D011328:Prions