Memories of virus-specific CD8+ T cells.
This brief review focuses on the way that our understanding of virus-specific CD8(+) T-cell-mediated immunity evolved, giving particular attention to the early impact of the program at the Australian National University. The story developed through a sequence of distinct eras, each of which can be defined in the context of the technologies available at that time. The progress has been enormous, but there is a great deal still to be learned. A particular challenge is to use what we know for human benefit.
Doherty
Peter C
PC
Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC, Australia. pcd@unimelb.edu.au
Turner
Stephen J
SJ
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014780:Viruses / Q000276:immunology*