[Immunohistochemical study of oral mucosa precancerous lesion and expression of cytokeratin of squamous cell carcinoma]
OBJECTIVE:The aim of this study was to investigate the expression and distribution of cytokeratin in oral mucosa. METHODS: Polyclonal cytokeratin antibody A(575) and ABC immunohistochemical technique were used. RESULTS: A tendency of progressive increase of cytokeratin expression was demonstrated from normal mucosa,mild moderate and severe dysplasia to squamous cell carcinoma. A notable overexpression was found in moderate,severe dysplasia and squamous cell carcinoma.The poor-differentiatin was related to the low reaction of A(575).The cases of strong reaction of A(575)were more advanced stages and metastasized to lymph nodes frquently. CONCLUSION: The overexpression of cytokeratin could play a role in potentiation the effects of genetic factors and activate oncogenes in the affected cells.The cumulative effects of the potentiation would be accelerate the progression of precancerous conditions.The reaction of A(575) was correlated with clinical stages and lymph node metastasis.
Liu
Z Z
ZZ
Hospital of Stomatology,Shandong Medical University. Jinan 250012, Shandong province, China.
Qi
X M
XM
Long
Y
Y