Carotid baroreflex function ceases during vasovagal syncope.
Despite the arterial baroreflex control of heart rate and blood pressure, vasovagal syncope is a common cause of loss of consciousness in people exposed to stimuli that reduce the central blood volume, such as head-up tilt. Carotid baroreflex function was evaluated using a rapid pulse train of neck pressure and neck suction in three conscious volunteers who developed a vasovagal episode during head-up tilt. The maximal gain of the carotid-heart rate and carotid-blood pressure baroreflex function curves were identified as measures of carotid baroreceptor responsiveness. When presyncopal symptoms developed, one further baroreflex assessment was obtained before the subjects were returned to the supine position. The bradycardia and hypotension exhibited during pre-syncope and syncope reflected a leftward and downward relocation of both the cardiac and vasomotor stimulus response curves. In addition, during the vasovagal syncope, baroreflex control was suppressed as blood pressure remained low during neck pressure stimuli. In conclusion, arterial baroreflex function ceases during vasovagal syncope.
Ogoh
Shigehiko
S
Department of Integrative Physiology, University of North Texas, Health Science Centre, Fort Worth, Texas, USA.
Volianitis
Stefanos
S
Raven
Peter B
PB
Secher
Niels H
NH
D000328:Adult; D017704:Baroreflex; D001794:Blood Pressure; D001810:Blood Volume; D002302:Cardiac Output; D002339:Carotid Arteries / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D018475:Head-Down Tilt; D006339:Heart Rate; D006801:Humans; D008297:Male; D009333:Neck; D011312:Pressure; D013318:Stroke Volume; D019462:Syncope, Vasovagal / Q000503:physiopathology*; D014666:Vasomotor System / Q000503:physiopathology