title: Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors.
abstract: In this study, fiber-mutant adenovirus vectors encoding chemokines, Ad-RGD-mCCL17, Ad-RGD-mCCL21 and Ad-RGD-mCCL22 were constructed. The insertion of integrin-targeting RGD sequence into fiber knob of adenovirus vectors notably enhanced the infection efficiency into tumor cells. Among three chemokine-encoding vectors evaluated, Ad-RGD-mCCL22 showed significant tumor-suppressive activity via transduction into OV-HM cells.
authors.affiliation: Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita City, Japan.
authors.forename: J Q
authors.initials: JQ
authors.lastname: Gao
authors.forename: L S
authors.initials: LS
authors.lastname: Alexandre
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuda
authors.forename: K
authors.initials: K
authors.lastname: Katayama
authors.forename: Y
authors.initials: Y
authors.lastname: Eto
authors.forename: F
authors.initials: F
authors.lastname: Sekiguchi
authors.forename: H
authors.initials: H
authors.lastname: Mizuguchi
authors.forename: T
authors.initials: T
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: O
authors.initials: O
authors.lastname: Yoshie
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: T
authors.initials: T
authors.lastname: Mayumi
authors.forename: S
authors.initials: S
authors.lastname: Nakagawa
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D018925:Chemokines / Q000235:genetics* / Q000502:physiology*; D005260:Female; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D051379:Mice; D009154:Mutation / Q000235:genetics; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy; D014407:Tumor Cells, Cultured
chemical_list: D018925:Chemokines