title: Production and use of fibrin glue at blood transfusion service of Bellaria-Maggiore Hospital Bologna.
abstract: FG is created by combining the two principal clotting factors found in plasma, fibrinogen and thrombin, whose natural function is to halt bleeding and seal tissues. We determined the safety, and efficacy of autologous FG by an automated device CryoSeal FS System. This procedure allows the blood transfusion center to produce a standardized product having similar characteristics of the pharmaceutical products available on the market and to produce a consistent amount of FG components from a single unit of autologous blood. The study involved a retrospective controlled evaluation of urologic patients compared with a control group operated of radical perineal prostatectomy. Blood loss difference is not significant. The hospital stay of the study group is shorter then the control group. The control group received more unit of homologous blood compared to the study group. This acquisition is suggestive for hypothetical blood saving.
authors.affiliation: Immunohematology and Transfusion Service, Maggiore-Bellaria Hospital Bologna, Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Zucchelli
authors.forename: A R
authors.initials: AR
authors.lastname: Silvestri
mesh_terms: D000368:Aged; D001803:Blood Transfusion / Q000379:methods*; D016022:Case-Control Studies; D015718:Fibrin Tissue Adhesive / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry; D006470:Hemorrhage; D006490:Hemostatics / Q000737:chemistry; D006761:Hospitals; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000601:surgery; D012189:Retrospective Studies; D013917:Thrombin / Q000737:chemistry; D014014:Tissue Adhesives / Q000737:chemistry; D014572:Urology / Q000379:methods; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D006490:Hemostatics; D014014:Tissue Adhesives; D005340:Fibrinogen; D013917:Thrombin