Immunohistochemical expression of progesterone receptors, growth hormone and insulin growth factor-I in feline fibroadenomatous change.
The immunohistochemical expression, tissue-specific and cell-specific distribution patterns of progesterone receptors (PR), growth hormone (GH) and insulin growth factor-I (IGF-I) have been studied in 22 cases of feline fibroadenomatous change (FFAC). PR and GH were detected in all cases and were distributed homogeneously throughout the lesion, while IGF-I was detected in 77% of the cases at the site of ductal budding. The simultaneous expression of PR, GH and IGF-I was detected in epithelial cells in 14 of 22 cases while PR and GH expression only was detected in epithelial cells in 11 cases. Cases that expressed GH and IGF-I without PR expression in the stroma were the most numerous. Double immunohistochemical staining showed the co-localisation of PR and GH in a subset of ductal epithelial cells located between basal/myoepithelial and luminal cells (probably undifferentiated stem cells). These results suggest that ligand-activated progesterone receptors may induce the local synthesis of GH which in turn may exert its proliferative action directly and also indirectly through the production of other growth factors, such as IGF-I, in an autocrine/paracrine manner.
Ordás
J
J
Departamento de Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Córdoba, Carretera de Madrid-Cadiz Km. 396, 14014 Córdoba, Spain.
Millán
Y
Y
de los Monteros
A Espinosa
AE
Reymundo
C
C
de las Mulas
J Martín
JM
D000818:Animals; D002371:Cat Diseases / Q000378:metabolism*; D002415:Cats; D005260:Female; D018226:Fibroadenoma / Q000378:metabolism* / Q000662:veterinary*; D013006:Growth Hormone / Q000378:metabolism; D007150:Immunohistochemistry / Q000662:veterinary; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015674:Mammary Neoplasms, Animal / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000096:biosynthesis*; D012189:Retrospective Studies
D011980:Receptors, Progesterone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone