title: Peak negative myocardial velocity gradient and wall-thickening velocity during early diastole are noninvasive parameters of left ventricular diastolic function in patients with Duchenne's progressive muscular dystrophy.
abstract: Myocardial velocity gradient and wall-thickening velocity were measured in the interventricular septum and left ventricular posterior wall (LVPW) by color-coded M-mode Doppler tissue echocardiography in patients with Duchenne's progressive muscular dystrophy (DMD) with a normal shortening fraction (n = 14) and age-matched control subjects (n = 40). In the LVPW, peak myocardial velocity gradients during systole and early diastole were significantly lower for patients with DMD than in control subjects (P <.0005, and P <.0001, respectively). Peak myocardial wall-thickening velocities of the LVPW during systole and early diastole were also lower for patients with DMD (P <.0005 and P <.0001, respectively). Mitral peak atrial to early filling velocity ratio was not significantly different between the 2 groups. The cut-off values of peak myocardial velocity gradients and wall-thickening velocities of the LVPW during early diastole for differentiation between patients with DMD and control subjects were -5.8/s and -6.0 cm/s, respectively (sensitivity/specificity: 93%/93% and 93%/85%, respectively). In conclusion, wall thinning during early diastole is frequently abnormal in patients with DMD, even when conventional echocardiographic findings are normal.
authors.affiliation: Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima-city, Japan. tonmaru@clin.med.tokushima-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mori
authors.forename: Takuji
authors.initials: T
authors.lastname: Edagawa
authors.forename: Miki
authors.initials: M
authors.lastname: Inoue
authors.forename: Masaki
authors.initials: M
authors.lastname: Nii
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakagawa
authors.forename: Yuka
authors.initials: Y
authors.lastname: Takehara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kuroda
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tatara
mesh_terms: D000293:Adolescent; D001783:Blood Flow Velocity / Q000502:physiology*; D002648:Child; D003326:Coronary Circulation / Q000502:physiology; D018619:Echocardiography, Doppler, Pulsed; D006339:Heart Rate / Q000502:physiology; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007564:Japan; D020388:Muscular Dystrophy, Duchenne / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000473:pathology*; D015588:Observer Variation; D012680:Sensitivity and Specificity; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*