title: [Etiology and clinical characters of hepatitis caused by non-hepatotropic virus].
abstract: OBJECTIVE
  To explore the etiology and clinical characters of hepatitis caused by non-hepatotropic virus.
  
  
  METHODS
  68 non-hepatotrophic viral hepatitis patients with negative anti-HAV-anti-HEV were diagnosed by detecting antibodies of anti-HSV IgM, anti-EBV IgM, anti-CMV IgM, anti-CSV IgM and anti-ANA, anti-mitochondrion antibody. Their clinical symptoms and signs were compared with that of acute viral hepatitis patients at the same time.
  
  
  RESULTS
  Among the 68 patients, 9 were infected by HSV, 12 by EBV, 8 by CMV, 14 by CSV, and the other 13 patients and 12 patients were positive for anti-ANA and anti-mitochondrion antibody, respectively. 35 of 43 non-hepatotrophic viral hepatitis patients were infected in winter and spring season. Their clinical symptoms and signs were milder than that of acute viral hepatitis patients.
  
  
  CONCLUSIONS
  Liver damage and dysfunction may be the prominent phenomenon during HSV, EBV, CMV and CSV infection, just like that of acute viral hepatitis but with milder clinical symptom and signs.
authors.affiliation: Department of Infectious Diseases, the Second Affiliated Hospital of Chongqing University Medical Sciences, Chongqing 400010, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhou
authors.forename: Ning
authors.initials: N
authors.lastname: Lai
authors.forename: Ming-tao
authors.initials: MT
authors.lastname: Wang
authors.forename: Zhong-yang
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Quan-hai
authors.initials: QH
authors.lastname: Zhang
authors.forename: Da-zhi
authors.initials: DZ
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Ren
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000209:etiology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D018139:Simplexvirus / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M