title: A toroid model for in vitro investigations of toxic shock syndrome toxin-1 production.
abstract: Human behaviours and consumer products may affect vaginal microbial ecology, thereby influencing women's health. Relevant experimentation systems are needed to understand such possible links. Here, we describe the development of a practical semi-solid in vitro model to assess the effects of interactions between vaginal environment and the presence of tampons, on bacterial communities, including the production of toxic shock syndrome toxin-1 (TSST-1) by Staphylococcus aureus.
authors.affiliation: Central Product Safety Division, Procter & Gamble Company, 11810 East Miami River Road, Colerain Township, OH 45252, USA. Flood.JA@pg.com
authors.forename: J A
authors.initials: JA
authors.lastname: Flood
authors.forename: T J
authors.initials: TJ
authors.lastname: Tripp
authors.forename: C C
authors.initials: CC
authors.lastname: Davis
authors.forename: D R
authors.initials: DR
authors.lastname: Hill
authors.forename: P M
authors.initials: PM
authors.lastname: Schlievert
mesh_terms: D001427:Bacterial Toxins / Q000096:biosynthesis*; D004768:Enterotoxins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008598:Menstruation; D008954:Models, Biological; D013211:Staphylococcus aureus / Q000254:growth & development* / Q000378:metabolism*; D018089:Superantigens / Q000096:biosynthesis*; D013630:Tampons, Surgical / Q000382:microbiology; D014621:Vagina / Q000382:microbiology
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal