title: Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries.
abstract: Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral L-arginine (4 weeks, 2 g, 3 times daily). L-arginine significantly improved angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma L-arginine, L-arginine:asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral L-arginine may represent a useful therapeutic option.
authors.affiliation: Division of Clinical Cardiology, Istituto Scientifico San Raffaele, Milan, Italy. altin_p@hotmail.com
authors.forename: Altin
authors.initials: A
authors.lastname: Palloshi
authors.forename: Gabriele
authors.initials: G
authors.lastname: Fragasso
authors.forename: PierMarco
authors.initials: P
authors.lastname: Piatti
authors.forename: Lucilla D
authors.initials: LD
authors.lastname: Monti
authors.forename: Emanuela
authors.initials: E
authors.lastname: Setola
authors.forename: Giampiero
authors.initials: G
authors.lastname: Valsecchi
authors.forename: Elena
authors.initials: E
authors.lastname: Galluccio
authors.forename: Sergio L
authors.initials: SL
authors.lastname: Chierchia
authors.forename: Alberto
authors.initials: A
authors.lastname: Margonato
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001120:Arginine / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D017566:Microvascular Angina / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D001120:Arginine