Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines.
A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in toluene. The absolute configuration of such addition products has been determined by x-ray crystallography.
Wei
Chunmei
C
Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.
Mague
Joel T
JT
Li
Chao-Jun
CJ