title: Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data.
abstract: Integration of the large variety of genome maps from several organisms provides the mechanism by which physiological knowledge obtained in model systems such as the rat can be projected onto the human genome to further the research on human disease. The release of the rat genome sequence provides new information for studies using the rat model and is a key reference against which existing and new rat physiological results can be aligned. Previously, we described comparative maps of the rat, mouse, and human based on EST sequence comparisons combined with radiation hybrid maps. Here, we use new data and introduce the Integrated Genomics Environment, an extensive database of curated and integrated maps, markers, and physiological results. These results are integrated by using VCMapview, a java-based map integration and visualization tool. This unique environment allows researchers to relate results from cytogenetic, genetic, and radiation hybrid studies to the genome sequence and compare regions of interest between human, mouse, and rat. Integrating rat physiology with mouse genetics and clinical results from human by using the respective genomes provides a novel route to capitalize on comparative genomics and the strengths of model organism biology.
authors.affiliation: Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. simont@mcw.edu
authors.forename: Simon N
authors.initials: SN
authors.lastname: Twigger
authors.forename: Jeff
authors.initials: J
authors.lastname: Nie
authors.forename: Victor
authors.initials: V
authors.lastname: Ruotti
authors.forename: Jiaming
authors.initials: J
authors.lastname: Yu
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.forename: Jed
authors.initials: J
authors.lastname: Mathis
authors.forename: Vijay
authors.initials: V
authors.lastname: Narayanasamy
authors.forename: Gopal R
authors.initials: GR
authors.lastname: Gopinath
authors.forename: Dean
authors.initials: D
authors.lastname: Pasko
authors.forename: Mary
authors.initials: M
authors.lastname: Shimoyama
authors.forename: Norberto
authors.initials: N
authors.lastname: De La Cruz
authors.forename: Susan
authors.initials: S
authors.lastname: Bromberg
authors.forename: Anne E
authors.initials: AE
authors.lastname: Kwitek
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Jacob
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Tonellato
mesh_terms: D000818:Animals; D002874:Chromosome Mapping / Q000379:methods; D019295:Computational Biology; D030541:Databases, Genetic; D020224:Expressed Sequence Tags; D023061:Gene Order / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D016678:Genome; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D051379:Mice; D020412:Multifactorial Inheritance / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D021101:Radiation Hybrid Mapping / Q000379:methods; D051381:Rats; D012984:Software
chemical_list: D005819:Genetic Markers