title: Primary hepatic non-Hodgkin's lymphoma in a patient with chronic hepatitis C: report of a case.
abstract: We report a case of primary hepatic non-Hodgkin's lymphoma in a 77-year-old man with chronic hepatitis C. Laboratory data revealed slightly elevated liver function parameters and positive antibody for hepatitis C virus (HCV). Abdominal ultrasonography showed a low-echogenic tumor, about 5 cm in diameter, in the left lateral segment. Abdominal computed tomography showed that the tumor was marginally enhanced in the early phase, but no enhancement was seen in the late phase. Magnetic resonance imaging showed that the tumor was hypointense in relation to the liver on T1-weighted images, but hyperintense on T2-weighted images. Hepatic angiography showed a homogeneously stained hypervascular tumor. Under the diagnosis of a liver tumor, thought to be a hepatocellular carcinoma, left lateral segmentectomy was performed. Histological examination confirmed a diagnosis of non-Hodgkin's diffuse large B-cell lymphoma that was positive for L-26 and CD79Alpha, but negative for CD3 and UCHL-1. The surrounding liver tissue showed signs of chronic active hepatitis. Multiple recurrent lesions were found in the liver, spleen, and iliac bones 4 months postoperatively. However, complete remission was achieved after five courses of systemic chemotherapy using pirarubicin, cyclophosphamide, vincristine sulfate, and prednisolone. The patient has been carefully followed up for about 1 year since his operation, and has been doing well. We review the literature on primary non-Hodgkin's lymphoma arising in the liver infected by HCV.
authors.affiliation: Department of Surgery II, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku-gun, Ishikawa, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kitabayashi
authors.forename: Taisuke
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Kei-ichi
authors.initials: K
authors.lastname: Ueno
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Saito
authors.forename: Takeo
authors.initials: T
authors.lastname: Kosaka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Takashima
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kurose
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nojima
mesh_terms: D000368:Aged; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D008297:Male