Regional delivery of vancomycin using pluronic F-127 to inhibit methicillin resistant Staphylococcus aureus (MRSA) growth in chronic otitis media in vitro and in vivo.
For the effective treatment of chronic otitis media caused by methicillin resistant Staphylococcus aureus (MRSA), the local delivery of vancomycin was attempted based on a formulation with pluronic F-127. The phase transition property of pluronic F-127, which is liquid at room temperature and becomes solid at body temperature, enabled convenient injection and reduced the side effects of the potent antibiotic. The temperature responsive polymer-vancomycin matrix system was also shown to effectively deliver vancomycin locally to the infected inner ear, plus the MRSA growth was inhibited by the formulation. The otitis media was completely cured by the sustained local delivery of vancomycin from the matrix in vivo. Accordingly, this system has potential clinical application for treating chronic otitis media with improved patient compliance and better therapeutic efficacy.
Lee
Sang Heun
SH
Department of Otolaryngology, School of Medicine, Kyungpook National University, Daegu 700-721, South Korea.
Lee
Ji Eun
JE
Baek
Woon Yi
WY
Lim
Jeong Ok
JO
D000818:Animals; D002908:Chronic Disease; D016503:Drug Delivery Systems / Q000379:methods*; D005849:Gerbillinae; D016106:Methicillin Resistance / Q000187:drug effects* / Q000502:physiology; D010033:Otitis Media / Q000188:drug therapy* / Q000473:pathology; D020442:Poloxamer / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development*; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics
D020442:Poloxamer; D014640:Vancomycin