Cardiac toxicity of alemtuzumab in patients with mycosis fungoides/Sézary syndrome.
Alemtuzumab is a monoclonal antibody to CD52 that has activity in T-cell leukemia and lymphoma. This study aims to describe the complications and outcomes of a subset of patients with mycosis fungoides/Sézary syndrome who were treated with alemtuzumab. Four of 8 patients, with no prior history of cardiac problems, developed significant cardiac toxicity (congestive heart failure or arrhythmia) that mostly improved after alemtuzumab discontinuation. The role of this agent in potentially inducing important cardiac side effects is suggested and argues for further investigation.
Lenihan
Daniel J
DJ
Department of Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, USA.
Alencar
Alvaro J
AJ
Yang
Deborah
D
Kurzrock
Razelle
R
Keating
Michael J
MJ
Duvic
Madeleine
M
D000328:Adult; D000368:Aged; D000074323:Alemtuzumab; D000911:Antibodies, Monoclonal / Q000633:toxicity*; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000633:toxicity*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D005260:Female; D006321:Heart / Q000187:drug effects*; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D012189:Retrospective Studies; D012751:Sezary Syndrome / Q000188:drug therapy*
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000912:Antibodies, Neoplasm; D000970:Antineoplastic Agents; D000074323:Alemtuzumab