title: Investigation of the potential heritability of persistent right aortic arch in Greyhounds.
abstract: In 2 successive matings of the same dam and sire in a Greyhound kennel, 1 of 6 puppies and 2 of 6 puppies were born with persistent right aortic arch (PRAA) in the first and second litters, respectively. Many congenital heart defects in dogs are believed to be heritable; however, proof of this has been difficult to obtain. Genetic predisposition to PRAA has been reported in German Shepherd Dogs and Irish Setters. The occurrence of PRAA in related Greyhounds within a kennel suggested a genetic predisposition to PRAA in a breed with which it has not been associated previously. Although the number of matings available for analysis was insufficient to conclusively prove a genetic basis for these observations, the occurrence of PRAA in puppies arising from successive matings of the same dam and sire strongly suggests that some lines of dogs of various breeds may be genetically predisposed to PRAA.
authors.affiliation: Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Gunby
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Hardie
authors.forename: Dale E
authors.initials: DE
authors.lastname: Bjorling
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000002:abnormalities*; D001018:Aortic Diseases / Q000235:genetics / Q000662:veterinary*; D001947:Breeding; D004285:Dogs / Q000002:abnormalities* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D010375:Pedigree; D011247:Pregnancy