title: Immunohistochemical analysis of CD31, CD36, and CD44 antigens in human omentum.
abstract: OBJECTIVE
  Milky spots in the human omental tissue are known to be consisting of lymphocytes, macrophages and mast cells. Our goal was to evaluate the relationship of lymphoid cells and macrophages with vasculature and stromal components.
  
  
  METHODS
  In this study we examined the biopsy specimens obtained from the adult patients whom were operated for different purposes in the General Surgery Department of Dicle University Hospital, Ankara, Turkey. We used CD31 as an endothelial cell marker, CD36 which is known to react with microvascular endothelium and adipocytes, and CD44 which is a hyaluronic acid receptor using an indirect immunoperoxidase technique.
  
  
  RESULTS
  We observed that CD31 was mainly reactive with vascular endothelial cells and platelets, CD36 was reactive with microvascular endothelium and adipocytes and CD44 was mainly expressed by the endothelial cells of high endothelial venules, fibroblasts in stromal compartments and by large mononuclear cells.
  
  
  CONCLUSIONS
  We determined the structural and immunophenotypic features of omental lymphoid tissue components stressing vascular and stromal elements, and we briefly discussed the significance of the expression of these molecules in the determined locations.
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Yildirim
authors.forename: Murat
authors.initials: M
authors.lastname: Akkus
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Nergiz
authors.forename: Sinan
authors.initials: S
authors.lastname: Yuruker
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D018955:CD36 Antigens / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D009852:Omentum / Q000378:metabolism*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: D018955:CD36 Antigens; D018960:Hyaluronan Receptors; D019408:Platelet Endothelial Cell Adhesion Molecule-1