Effect of dietary clenbuterol and cimaterol on muscle composition, beta-adrenergic and androgen receptor concentrations in broiler chickens.
Illegal dietary supplementation with beta(2)-agonists has been shown to increase protein deposition and decrease fat accretion in domestic animals. In poultry the metabolic and endocrine responses to beta(2)-agonists are not fully elucidated. In this trial the effects of dietary clenbuterol (1 p.p.m.) and cimaterol (1 p.p.m.) on muscle composition and endocrine response of male broiler chickens were studied. Dietary clenbuterol induced a slight, but in general not significant, improvement of zootechnical performances and carcass yields. Chemical composition of muscle was not influenced by dietary treatments, even if a slight improvement of protein content was observed in treated groups. No effects on fatty acid composition of meat were detected. Both clenbuterol and cimaterol treatments caused a downregulation in testicular androgen receptors and in pulmonary, cardiac and central nervous system beta-adrenergic receptors.
Schiavone
A
A
Dipartimenti di Produzioni Animali, Epidemiologia ed Ecologia, Universita di Torino, Grugliasco (TO), Italy.
Tarantola
M
M
Perona
G
G
Pagliasso
S
S
Badino
P
P
Odore
R
R
Cuniberti
B
B
Lussiana
C
C
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000494:pharmacology; D000821:Animal Feed; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D002645:Chickens / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D002976:Clenbuterol / Q000008:administration & dosage* / Q000494:pharmacology; D019587:Dietary Supplements; D015536:Down-Regulation / Q000187:drug effects; D004983:Ethanolamines / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D011897:Random Allocation; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D011944:Receptors, Androgen / Q000187:drug effects* / Q000378:metabolism; D015430:Weight Gain
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D011943:Receptors, Adrenergic, beta; D011944:Receptors, Androgen; D002976:Clenbuterol; C047411:cimaterol