title: New nitrogenous Germacranes from a Thai marine sponge, Axinyssa n. sp.
abstract: Two new germacrane sesquiterpenes, including (1Z,4Z)-7alphaH-11-aminogermacra-1(10),4-diene (1) and N,N'-11-bis[(1Z,4Z)-7alphaH-germacra-1(10),4-dienyl]urea (2), were isolated from a Thai marine sponge Axinyssan. sp. collected from the Andaman Sea. The structure elucidations of 1 and 2 were accomplished by means of 1D and 2D NMR, MS, and IR spectroscopy. Only 1 exhibited strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, and Candida albicans.
authors.affiliation: Bioactive Marine Natural Products Chemistry Research Unit (BMNCU), Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
authors.forename: Veena
authors.initials: V
authors.lastname: Satitpatipan
authors.forename: Khanit
authors.initials: K
authors.lastname: Suwanborirux
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009584:Nitrogen; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: C485039:7alphaH-11-aminogermacra-1(10),4-diene; D000900:Anti-Bacterial Agents; C485040:N,N'-11-bis((1Z,4Z)-7alphaH-germacra-1(10),4-dienyl)urea; D045788:Sesquiterpenes, Germacrane; D009584:Nitrogen