Longitudinal changes of solute transport in peritonitis-free peritoneal dialysis patients.
BACKGROUND
The aim of this study was to evaluate the longitudinal changes in peritoneal transport in patients on long-term, peritonitis-free, continuous ambulatory peritoneal dialysis (CAPD) therapy.


METHODS
Results were longitudinally recorded for the standard peritoneal equilibration test (PET) in 76 consecutive, nondiabetic, adult patients from the beginning of CAPD therapy until their first episodes of peritonitis, abdominal surgery, or any cause of drop out. The PET results were evaluated once annually using the dialysate-to-plasma ratio of creati-nine (D/PCr) and the dialysate-to-instilled dextrose ratio (D4/D0) at 4 hours after beginning dialysis.


RESULTS
A total of 168 PET results were obtained. A statistically significant tendency toward decreased D/PCr and increased D4/D0 values over time for up to 3 years was found.


CONCLUSIONS
This study shows a tendency toward progressive decline in small molecular transport over time in nondiabetic patients with uneventful CAPD therapy. Sequential PET follow-up cannot be overlooked in peritonitis-free CAPD patients.
Hung
Shih-Yuan
SY
Division of Nephrology, E-Da Hospital, I-Shou University, and Fooyin University, Kaohsiung County, Taiwan.
Hung
Yao-Min
YM
Chiou
Yee-Hsuan
YH
Chou
Kang-Ju
KJ
Chung
Hsiao-Min
HM
D000328:Adult; D001692:Biological Transport / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D010537:Peritoneum / Q000502:physiology*; D010538:Peritonitis; D016896:Treatment Outcome