Completion by the 10th generation of the bidirectional selective breeding of GHB-sensitive and GHB-resistant rats.
The present paper describes the completion of the bidirectional selective breeding of gamma-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats, which display opposite sensitivity to the sedative/hypnotic effect of 1 g/kg GHB. Completion of the selective breeding process was achieved by the F10, when 100% of rats of each line fulfilled the selection criterion. GHB-S and GHB-R rats may constitute a valuable tool for investigations on GHB physiology and pharmacology.
Lobina
Carla
C
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy.
Colombo
Giancarlo
G
Gessa
Gian Luigi
GL
Carai
Mauro A M
MA
D000818:Animals; D001947:Breeding / Q000379:methods*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains / Q000235:genetics*; D012890:Sleep / Q000187:drug effects; D013045:Species Specificity
D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid