A novel one-pot, four component synthesis of some densely functionalized pyrroles.
A new one-pot four component procedure for synthesis of densely functionalized pyrroles using commercially available ninhydrin with phosphorane intermediates produced in the reaction between triphenylphosphine, ammonium thiocyanate (or ammonium acetate) and various dialkyl acetylenedicarboxylates was developed.
Azizian
Javad
J
Department of Chemistry, Faculty of Science, Shahid Beheshti University, Tehran, Iran. J-Azizian@cc.sbu.ac.ir
Karimi
Ali R
AR
Arefrad
Hamedeh
H
Mohammadi
Ali A
AA
Mohammadizadeh
M R
MR
D000085:Acetates / Q000737:chemistry; D000114:Acetylene / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D015394:Molecular Structure; D009555:Ninhydrin / Q000737:chemistry / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000737:chemistry; D010753:Phosphoranes / Q000737:chemistry / Q000378:metabolism; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013861:Thiocyanates / Q000737:chemistry
D000085:Acetates; D002264:Carboxylic Acids; D009943:Organophosphorus Compounds; D010753:Phosphoranes; D011758:Pyrroles; D013861:Thiocyanates; C061896:triphenylphosphine; C026976:thiocyanic acid; D009555:Ninhydrin; D000114:Acetylene; C018824:ammonium acetate