title: Episodic macroglossia as the sole manifestation of angiotensin-converting enzyme inhibitor-induced angioedema.
abstract: We describe a patient who had recurrent life-threatening episodes of isolated macroglossia due to the use of an angiotensin-converting enzyme (ACE) inhibitor. No associated facial, labial, pharyngeal, or laryngeal edema was noted. Aggressive treatment with epinephrine, steroids, and antihistamines resulted in rapid resolution of the tongue swelling and respiratory distress. Recurrent isolated angioedema of the tongue is an extremely rare variant of ACE inhibitor-related angioneurotic edema. The widespread use of ACE inhibitors mandates a special awareness by physicians of this potentially life-threatening yet treatable side effect.
authors.affiliation: Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
authors.forename: Yaacov
authors.initials: Y
authors.lastname: Rabinowitz
authors.forename: Miriam
authors.initials: M
authors.lastname: Lorberbaum
authors.forename: Vadim
authors.initials: V
authors.lastname: Nisanewitz
mesh_terms: D000368:Aged; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D004656:Enalapril / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008260:Macroglossia / Q000139:chemically induced*; D008297:Male
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril