An error catastrophe in cancer?
A comparison between the evolution of cancer cell populations and RNA viruses reveals a number of remarkable similarities. Both display high levels of plasticity and adaptability as a consequence of high degrees of genetic variation. It has been suggested that, as it occurs with RNA viruses, there is a threshold in the levels of genetic instability affordable by cancer cells in order to be able to overcome selection barriers (Trends Genet. 15 (1999) M57). Here we explore this concept by means of a simple mathematical model. It is shown that an error threshold exists in this model, which investigates both competition between cancer cell populations and its impact on overall tumor growth dynamics. Once the threshold is reached, the highly unstable tumor cell populations, which were sustaining malignant growth, become unable to maintain their genetic information, which in turn triggers a slowed down overall tumor growth regime.
Solé
Ricard V
RV
ICREA-Complex Systems Lab, Universitat Pompeu Fabra, Barcelona, Spain. ricard.sole@cexs.upf.es
Deisboeck
Thomas S
TS
D000818:Animals; D002455:Cell Division / Q000235:genetics; D018450:Disease Progression; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D012328:RNA Viruses / Q000235:genetics