Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism.
In analogy with maribavir [1-(beta-L-ribofuranosyl)-isopropylamino-5,6-dichlorobenzimidazole], a nucleoside analogue that acts against human cytomegalovirus (HCMV) by a non-nucleoside mechanism, here I present three other examples of classes of nucleoside analogues (i.e. bicyclic furo[2,3-d]pyrimidine as well as HEPT and TSAO derivatives) that act against either HCMV or human immunodeficiency virus (HIV) through a non-nucleoside mode of action.
De Clercq
Erik
E
Rega Institute for Medical Research, Leuven, Belgium. erik.declercq@rega.kuleuven.ac.be
D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000494:pharmacology*
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides