title: Full-thickness skin necrosis after arginine extravasation--a case report and review of literature.
abstract: The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin necrosis that requires serious surgical intervention with aesthetic and functional sequellea. The authors describe a case of distal forearm skin necrosis caused by arginine extravasation that was treated by wide debridement and a combination of groin flap and later with split-thickness skin graft. The authors emphasize the need for early and active management of arginine extravasation injuries.
authors.affiliation: Department of Orthopedic Surgery Haemek Medical Center, Afula, Israel.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Salameh
authors.forename: Aziz
authors.initials: A
authors.lastname: Shoufani
mesh_terms: D001120:Arginine / Q000009:adverse effects*; D002675:Child, Preschool; D003646:Debridement; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D004393:Dwarfism, Pituitary / Q000175:diagnosis; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000473:pathology* / Q000601:surgery; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects; D009336:Necrosis; D012867:Skin / Q000293:injuries* / Q000473:pathology; D016038:Skin Transplantation; D013524:Surgical Flaps; D014953:Wrist
chemical_list: D019382:Human Growth Hormone; D001120:Arginine