Unfaithful DNA polymerase caught in the act.
The 3D structures of all 12 mispairs formed in the active site of a DNA polymerase help explain their differential effects on polymerase stalling and on translocation of the primer terminus to the enzyme's proofreading site.
Jiricny
Josef
J
Institute of Molecular Cancer Research, University of Zürich, August Forel-Strasse 7, CH-8008 Zurich, Switzerland.
D020137:Base Pair Mismatch; D020029:Base Pairing; D001483:Base Sequence; D001665:Binding Sites; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D005092:Exonucleases / Q000378:metabolism; D009690:Nucleic Acid Conformation; D009692:Nucleic Acid Heteroduplexes; D014178:Translocation, Genetic
D009692:Nucleic Acid Heteroduplexes; D004259:DNA-Directed DNA Polymerase; D005092:Exonucleases