title: Optimized prostate biopsy via a statistical atlas of cancer spatial distribution.
abstract: A methodology is presented for constructing a statistical atlas of spatial distribution of prostate cancer from a large patient cohort, and it is used for optimizing needle biopsy. An adaptive-focus deformable model is used for the spatial normalization and registration of 100 prostate histological samples, which were provided by the Center for Prostate Disease Research of the US Department of Defense, resulting in a statistical atlas of spatial distribution of prostate cancer. Based on this atlas, a statistical predictive model was developed to optimize the needle biopsy sites, by maximizing the probability of detecting cancer. Experimental results using cross-validation show that the proposed method can detect cancer with a 99% success rate using seven needles, in these samples.
authors.affiliation: Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 380, Philadelphia, PA 19104-2644, USA. dgshen@rad.upenn.edu
authors.forename: Dinggang
authors.initials: D
authors.lastname: Shen
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Lao
authors.forename: Jianchao
authors.initials: J
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Isabel A
authors.initials: IA
authors.lastname: Sesterhenn
authors.forename: Leon
authors.initials: L
authors.lastname: Sun
authors.forename: Judd W
authors.initials: JW
authors.lastname: Moul
authors.forename: Edward H
authors.initials: EH
authors.lastname: Herskovits
authors.forename: Gabor
authors.initials: G
authors.lastname: Fichtinger
authors.forename: Christos
authors.initials: C
authors.lastname: Davatzikos
mesh_terms: D000465:Algorithms; D001707:Biopsy, Needle / Q000706:statistics & numerical data; D015331:Cohort Studies; D003198:Computer Simulation; D005544:Forecasting; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000706:statistics & numerical data; D021621:Imaging, Three-Dimensional / Q000706:statistics & numerical data; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical; D011336:Probability; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*; D015203:Reproducibility of Results