title: Current therapy and the development of therapeutic options for the treatment of diseases due to bacterial agents of potential biowarfare and bioterrorism.
abstract: An important part of biodefense is the optimization of current therapy and the development of new therapeutic options for the treatment of the diseases most likely encountered in the form of biological weapons. Guidelines for the prevention and treatment of anthrax, plague, tularemia and botulinum toxin intoxication are reviewed. The strategies in development for the prevention of anthrax focus primarily on active and passive immunization against protective antigen, because of its central role as a toxin delivery module. Novel vaccine strategies for plague, tularemia and botulism are also reviewed.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, University of Oklahoma Health Sciences Center, 920 Stanton Young Blvd, Oklahoma City, OK 73190, USA. Ronald-Greenfield@OUHSC.edu
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Greenfield
authors.forename: Michael S
authors.initials: MS
authors.lastname: Bronze
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000379:methods; D001424:Bacterial Infections / Q000188:drug therapy* / Q000517:prevention & control; D001694:Biological Warfare / Q000379:methods*; D023482:Bioterrorism / Q000517:prevention & control; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents