[The role of endothelin-1 in the pathogenesis of septic shock in the abdominal sepsis].
Role of endoteline-1 (ET-1) in pathogenesis of septic shock (SS) was studied in 22 patients in the age from 34 to 58 years. There was shown, that ET-1 content in plasma depends on functional level of the adaptation-compensation reaction of organism as an answer on occurrence of SS in patients with abdominal sepsis. This is demonstrated by more high concentration of the index studied in the patients survived and also presence of correlative connection between ET-1 level in plasma of blood, indexes of middle arterial pressure and general peripheral resistance of vessels. There were received preliminary data, witnessing, that circulating cytokines, in particular, interleukin-8, stimulate the heightened production of ET-1 by endothelial cells, what probably in early terms the SS course constitutes the compensatory reaction, directed on elimination of pathogenic microorganisms, securing of reparative processes and maintenance of homeostasis.
Krivoruchko
I A
IA
Boĭko
V V
VV
Gusak
I V
IV
Andreeshchev
S A
SA
D018784:Abdominal Abscess / Q000453:epidemiology* / Q000378:metabolism*; D000328:Adult; D019332:Endothelin-1 / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008875:Middle Aged; D012772:Shock, Septic / Q000378:metabolism / Q000401:mortality / Q000473:pathology
D019332:Endothelin-1; D006854:Hydrocortisone