title: Immunogenicity of Trichophyton mentagrophytes isolated from arctic foxes with ringworm.
abstract: Immunogenicity of six strains of Trichophyton mentagrophytes var. granulosum isolated from arctic foxes with ringworm was evaluated in guinea pigs and foxes. Two strains of T. mentagrophytes (Tm-3 and Tm-4) out of six examined (Tm-1, Tm-2, Tm-3, Tm-4, Tm-5 and Tm-6) induced in the experimental foxes a strong cellular immune response measured by the leukocyte migration inhibition test (LMIT), lymphocyte transformation test (LTT), and by skin delayed-type hypersensitivity (DTH). The guinea pigs immunised with Tm-3 and Tm-4 were well protected against the artificial infection with the virulent strain of T. mentagrophytes (Tm-9). These two strains of T. mentagrophytes with high immunogenic properties were used for production of a vaccine against ringworm in foxes.
authors.affiliation: Department of Epizootiology and Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Agriculture, Głeboka 30, 20-612 Lublin, Poland. kkostro@wp.pl
authors.forename: K
authors.initials: K
authors.lastname: Kostro
mesh_terms: D000818:Animals; D002464:Cell Migration Inhibition; D005260:Female; D005589:Foxes; D005657:Fungal Vaccines / Q000276:immunology*; D006168:Guinea Pigs; D007111:Immunity, Cellular; D016233:Immunotherapy, Active / Q000662:veterinary; D008213:Lymphocyte Activation; D008297:Male; D012882:Skin Tests; D014005:Tinea / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014249:Trichophyton / Q000145:classification / Q000472:pathogenicity*; D014611:Vaccination / Q000662:veterinary
chemical_list: D005657:Fungal Vaccines