Effect of composition on the physicochemical properties and active substance release from gelatin-alginate sponge.
The aim the study was physicochemically characterize and develop ability of the active substance (cefradine) from the implantable porous carriers. The drug delivery systems consisting of the gelatine and alginic acid sodium salt and glycerol (GL) or peanut oil (AO). Gelatin-alginate sponge was prepared by foamed components and next freeze-dried this foam. The composition of the sponges affected on the sorption ability and on the stability to proteolytic enzymes. Owing to porous structure obtained specific profile of active substance release.
Haznar
Dorota
D
Department of Applied Pharmacy, Wrocław Medical University.
Pluta
Janusz
J
D000464:Alginates / Q000138:chemical synthesis* / Q000737:chemistry* / Q000493:pharmacokinetics; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D002515:Cephradine / Q000493:pharmacokinetics*; D004337:Drug Carriers; D004339:Drug Compounding; D005612:Freeze Drying; D005780:Gelatin; D005781:Gelatin Sponge, Absorbable / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D020723:Glucuronic Acid / Q000737:chemistry*; D005990:Glycerol / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry*; D000074241:Peanut Oil; D010938:Plant Oils / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
D000464:Alginates; D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D006603:Hexuronic Acids; D000074241:Peanut Oil; D010938:Plant Oils; D011108:Polymers; D020723:Glucuronic Acid; D005780:Gelatin; D002515:Cephradine; D005990:Glycerol