title: Intussusception and rotavirus vaccines: what is the background risk?
abstract: The first rotavirus vaccine was associated with a small, albeit statistically significant, risk of intussusception in immunized infants. Before results of new vaccine studies are available, we need to define the real background risk of intussusception in participating countries. A 5-year retrospective study conducted in Panama found an average rate of 1 case per 3300 infants younger than 1 year of age, with substantial yearly variations ranging from 1:2500 to 1:5000.
authors.affiliation: Pediatrics, University of Panama, Panama City, Panama.
authors.forename: Xavier
authors.initials: X
authors.lastname: Sáez-Llorens
authors.forename: Javier Nieto
authors.initials: JN
authors.lastname: Guevara
mesh_terms: D017677:Age Distribution; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007443:Intussusception / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D010176:Panama / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012400:Rotavirus Infections / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D012720:Severity of Illness Index; D017678:Sex Distribution; D015996:Survival Rate; D014611:Vaccination / Q000009:adverse effects
chemical_list: D022243:Rotavirus Vaccines