title: [Hemisensory impairment in neuropathic pain following chronic radiculopathy].
abstract: BACKGROUND
  Modern pathophysiological concepts indicate that the central nervous system is important for chronification of pain in cases of neuropathic pain. Taking these concepts into consideration, what significance then do those hemisensory disorders have that appear sporadically in cases of chronic nerve root irritation syndrome?
  
  
  RESULTS
  The typical clinical findings are illustrated by two case reports. In addition to persistent neuropathic pain, both patients experienced hemisensory impairment of the entire side of the body ipsilateral to the radicular symptoms. Perception of sensitivity to touch, pain, and temperature was decreased on the entire side of the body in contrast to the contralateral side.
  
  
  CONCLUSIONS
  Hemisensory impairment in patients with chronic nerve root irritation syndromes can indicate a functional disorder in dealing with noxious impulses in the ventral posterior nucleus of the thalamus. They represent a clinical correlative to subcortical neuroplasticity, which could explain the resistance to therapy in severe chronic pain syndromes.
authors.affiliation: Neurologische Klinik und Poliklinik, BG-Klinikum Bergmannsheil Bochum. Oliver-Rommel@gmx.de
authors.forename: O
authors.initials: O
authors.lastname: Rommel
authors.forename: A
authors.initials: A
authors.lastname: Maercklin
authors.forename: A
authors.initials: A
authors.lastname: Eichbaum
authors.forename: A
authors.initials: A
authors.lastname: Kuprian
authors.forename: G
authors.initials: G
authors.lastname: Jäger
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use; D000700:Analgesics / Q000627:therapeutic use; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy / Q000209:etiology*; D010468:Perceptual Disorders / Q000188:drug therapy / Q000209:etiology*; D011843:Radiculopathy / Q000503:physiopathology*
chemical_list: D000700:Analgesics; D000639:Amitriptyline