A new solution for improving gene delivery.
Intense research has focused on methods for overcoming the various barriers to DNA delivery while simultaneously reducing toxicity. Recently, Yuan and colleagues discovered a 'leakage route', whereby viral vectors escaped the injection site and entered the systemic circulation and contributed to the systemic toxicity in cancer gene therapy. They also demonstrated that alginate solution sealed this leak. Although their work focused on intratumoral injection of viral vectors, the findings can be extended to drug delivery in general, particularly DNA delivery.
Luo
Dan
D
Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14850, USA. dl79@cornell.edu
D000256:Adenoviridae / Q000235:genetics; D000464:Alginates / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D004058:Diffusion; D015870:Gene Expression; D017930:Genes, Reporter / Q000235:genetics; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000008:administration & dosage; D015552:Injections, Intralesional; D018664:Interleukin-12 / Q000235:genetics; D008099:Liver / Q000737:chemistry; D051379:Mice; D008833:Microcirculation / Q000187:drug effects; D009369:Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000628:therapy*; D011312:Pressure
D000464:Alginates; D018664:Interleukin-12