title: Comparison of two methods of treatment for intraluminal thermal ablation using an ultrasound cylindrical phased array.
abstract: Intraluminal (within the alimentary tract) thermal surgery has been shown to be a useful therapeutic option when extracorporeal focused ultrasound applicators cannot be used since their beam may not reach the target site. If plane transducers are used for the treatment of alimentary tract tumours, the applicator must be rotated in order to generate a cylindrical volume of necrosis. However, rotating these applicators and controlling their shooting direction presents technical difficulties. If tubular transducers are used it is difficult to treat arbitrary angles with a large therapeutic length. To solve these difficulties, the feasibility of an ultrasound phased array applicator has been evaluated using a cylindrical prototype (outer diameter 10.6 mm), which is composed of 16 elementary transducers working at 4.55 MHz and arranged on a quarter of the cylinder. Using this applicator it is possible to generate plane or cylindrical waves. Plane waves were generated by exciting eight successive elements of the array with appropriate delay times. The exposure direction was changed by exciting a different set of eight elements. In this way, the ultrasound beam was electronically rotated through the tissues. Cylindrical waves were generated by exciting several transducers without delay times. Imaging was provided using a miniature echographic probe. Ex vivo experiments were carried out in pig liver to compare two approaches of treatment. The first consisted of generating successive plane waves separated from each other by a 6 degrees angle. The second one consisted of exciting all the 16 elements without delay times. In the two cases, the lesions were well-defined and occupied a quarter of cylinder. In both sets of experiments, the sonication time and the intensity were 20 s and 17 W/cm(2), respectively. In the first case, the depth was up to 17 mm compared to 6 mm in the second case.
authors.affiliation: INSERM, Unit 556, 151 Cours Albert Thomas, Lyon, cedex 03 69424, France. melodelima@lyon.inserm.fr
authors.forename: David
authors.initials: D
authors.lastname: Melodelima
authors.forename: Frédéric
authors.initials: F
authors.lastname: Prat
authors.forename: Alain
authors.initials: A
authors.lastname: Birer
authors.forename: Yves
authors.initials: Y
authors.lastname: Theillère
authors.forename: Dominique
authors.initials: D
authors.lastname: Cathignol
mesh_terms: D000818:Animals; D004867:Equipment Design; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D066298:In Vitro Techniques; D008113:Liver Neoplasms / Q000628:therapy*; D009336:Necrosis; D013552:Swine; D014464:Ultrasonic Therapy / Q000379:methods*; D014867:Water
chemical_list: D014867:Water