Zinc sensing for cellular application.
Numerous tools for Zn2+ sensing in living cells have become available in the past three years. Among them, fluorescence imaging using fluorescent sensor molecules has been the most popular approach. Some of these sensor molecules can be used to visualize Zn2+ in living cells. Some of the biological functions of Zn2+ have been clarified using these sensor molecules, especially in neuronal cells, which contain a high concentration of free Zn2+.
Kikuchi
Kazuya
K
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. kkikuchi@mol.f.u-tokyo.ac.jp
Komatsu
Kensuke
K
Nagano
Tetsuo
T
D015374:Biosensing Techniques; D019793:Fluorescein; D005456:Fluorescent Dyes / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D015032:Zinc / Q000032:analysis*
D005456:Fluorescent Dyes; D010455:Peptides; D011506:Proteins; D015032:Zinc; D019793:Fluorescein