title: Comparison of different ibuprofen-amino acid compounds with respect to emulsifying and cytotoxic properties.
abstract: Sodium ibuprofen (Ibu-Na) and different ibuprofen-amino acid compounds, lysinate (Ibu-Lys), arginate (Ibu-Arg) and histidinate (Ibu-His), were evaluated for emulsifying, haemolytic and cytotoxic properties. The highest reduction of surface tension was obtained with Ibu-Lys which shows good emulsifying qualities. At the same time, Ibu-Lys reveals the highest haemolytic activity and affects porcine cornea integrity. However, incorporation of Ibu-Lys into an emulsion system significantly decreases haemolysis. On the contrary Ibu-Arg, which shows a lower surface tension reduction, allows, unlike Ibu-Na and Ibu-His, for comparably stable emulsions with comparable erythrocyte damage.
authors.affiliation: Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstr. 1, 38106 Braunschweig, Germany.
authors.forename: Luma
authors.initials: L
authors.lastname: Baydoun
authors.forename: Andreas
authors.initials: A
authors.lastname: Düvel
authors.forename: Rolf
authors.initials: R
authors.lastname: Daniels
authors.forename: Andreas
authors.initials: A
authors.lastname: Drust
authors.forename: Thorsten
authors.initials: T
authors.lastname: Goldhagen
authors.forename: Irina
authors.initials: I
authors.lastname: Schwan
authors.forename: Christian
authors.initials: C
authors.lastname: Zeidler
authors.forename: Christel C
authors.initials: CC
authors.lastname: Müller-Goymann
mesh_terms: D000328:Adult; D000818:Animals; D001120:Arginine / Q000633:toxicity*; D003315:Cornea / Q000187:drug effects; D004338:Drug Combinations; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry / Q000633:toxicity*; D004655:Emulsions; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007052:Ibuprofen / Q000031:analogs & derivatives / Q000737:chemistry / Q000633:toxicity*; D008239:Lysine / Q000031:analogs & derivatives / Q000633:toxicity*; D008297:Male; D013500:Surface Tension / Q000187:drug effects; D013552:Swine
chemical_list: D004338:Drug Combinations; D045703:Emulsifying Agents; D004655:Emulsions; D001120:Arginine; D008239:Lysine; C016106:solufenum; D007052:Ibuprofen; C106674:ibuprofen arginine