[The interaction of stilbazolium merocyanines with hyperproliferative laryngeal papilloma cells--preliminary study].
Recently increasing interest focused in possible clinical application on photodynamic therapy was observed. Many scientists are looking for new chemical compounds effective in therapy and giving no side effects. Stilbazolium merocyanines belong to lipophilic dyes, binding to cell membranes. The aim of this study was to estimate the usefulness of the selected stilbazolium merocyanines to treatment on human recurrent respiratory papillomatosis. A patients group consisted of seven children, ages 10 months to 18 years, with moderate to severe recurrent disease. The patients were treated surgically. Tissue samples were analyzed for presence of Human papillomavirus (HPV). The incorporation of the dye into papillomas cells membranes was measured by flow cytometry. As a measure of fluorescence intensitivity the value "mean channel" was used. The hyperplastic tissue showed the highest fluorescence intensity than normal epithelium. Obtained results showed that continue to this preliminary studies is necessary.
Szydłowski
Jarosław
J
Klinika Otolaryngologii Dzieciecej Instytutu Pediatrii AM im. Karola Marcinkowskiego w Poznaniu.
Cofta
Justyna
J
Wiktorowicz
Krzysztof
K
Grzegorowski
Michał
M
D000293:Adolescent; D001597:Benzylidene Compounds / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010212:Papilloma / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods
D001597:Benzylidene Compounds; D004095:Dihydropyridines; C095319:stilbazolium merocyanine