Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.
Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.
Smits
Kim M
KM
University Maastricht, Maastricht, The Netherlands.
Benhamou
Simone
S
Garte
Seymour
S
Weijenberg
Matty P
MP
Alamanos
Yannis
Y
Ambrosone
Christine
C
Autrup
Herman
H
Autrup
Judith L
JL
Baranova
Helena
H
Bathum
Lisa
L
Boffetta
Paolo
P
Bouchardy
C
C
Brockmoller
Jurgen
J
Butkiewicz
Dorota
D
Cascorbi
Ingolf
I
Clapper
Margie L
ML
Coutelle
Christiane
C
Daly
Ann K
AK
Muzi
Giacomo
G
Dolzan
Vita
V
Duzhak
Tatyana G
TG
Farker
Katrin
K
Golka
Klaus
K
Haugen
Aage
A
Hein
David W
DW
Hildesheim
Allan
A
Hirvonen
Ari
A
Hsieh
Ling L
LL
Ingelman-Sundberg
Magnus
M
Kalina
Ivan
I
Kang
Daehee
D
Katoh
Takahiko
T
Kihara
Masahiro
M
Ono-Kihara
Masako
M
Kim
Heon
H
Kiyohara
Chikako
C
Kremers
Pierre
P
Lazarus
Philip
P
Le Marchand
Loic
L
Lechner
Maria C
MC
London
Stephanie
S
Manni
Johannes J
JJ
Maugard
Christine M
CM
Morgan
Gareth J
GJ
Morita
Shunji
S
Nazar-Stewart
Valle
V
Kristensen
Vessela Nedelcheva
VN
Oda
Yoshio
Y
Parl
Fritz F
FF
Peters
Wilbert H M
WH
Rannug
Agneta
A
Rebbeck
Timothy
T
Pinto
Luis F Ribeiro
LF
Risch
Angela
A
Romkes
Marjorie
M
Salagovic
Jan
J
Schoket
Bernadette
B
Seidegard
Janeric
J
Shields
Peter G
PG
Sim
Edith
E
Sinnett
Daniel
D
Strange
Richard C
RC
Stucker
Isabelle
I
Sugimura
Haruhiko
H
To-Figueras
Jordi
J
Vineis
Paolo
P
Yu
Mimi C
MC
Zheng
Wei
W
Pedotti
Paola
P
Taioli
Emanuela
E
D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D011110:Polymorphism, Genetic; D012907:Smoking / Q000235:genetics*
D001191:Arylamine N-Acetyltransferase; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007527:Isoenzymes; C478900:NAT2 protein, human; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human