Synthesis of ganglioside epitopes for oligosaccharide specific immunoadsorption therapy of Guillian-Barré syndrome.
Guillain-Barré syndrome is a postinfectious, autoimmune neuropathy resulting in neuromuscular paralysis. Auto-antibodies, often induced by bacterial infection, bind to human gangliosides possessing monosialoside and diasialoside epitopes and impair the function of nerve junctions, where these ganglioside structures are highly enriched. Truncated gangliosides representive of GD3, GQ1b and GM2 epitopes have been synthesized as methyl glycosides and as a glycosides of an eleven carbon tether. The synthetic oligosaccharide ligands are structural mimics of these highly complex ganglioside epitopes and via their ability to neutralize or remove auto-antibodies have the potential for therapy, either as soluble blocking ligands administered systemically, or as immuno-affinity ligands for use as extracorporeal immunoadsorbents.
Andersen
Søren M
SM
Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
Ling
Chang-Chun
CC
Zhang
Ping
P
Townson
Kate
K
Willison
Hugh J
HJ
Bundle
David R
DR
D000911:Antibodies, Monoclonal / Q000276:immunology; D000937:Antigen-Antibody Reactions; D002240:Carbohydrate Sequence; D005678:G(M2) Ganglioside / Q000138:chemical synthesis* / Q000627:therapeutic use; D005732:Gangliosides / Q000138:chemical synthesis* / Q000627:therapeutic use; D020275:Guillain-Barre Syndrome / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007163:Immunosorbent Techniques; D007164:Immunosorbents / Q000494:pharmacology; D008024:Ligands; D008969:Molecular Sequence Data; D003473:Neuromuscular Nondepolarizing Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D009844:Oligosaccharides / Q000276:immunology*
D000911:Antibodies, Monoclonal; D005732:Gangliosides; D007164:Immunosorbents; D008024:Ligands; D003473:Neuromuscular Nondepolarizing Agents; D009844:Oligosaccharides; D005678:G(M2) Ganglioside; C026226:ganglioside, GD3; C039129:GQ1b ganglioside