title: Preparative resolution of 1-aminoindan-1,5-dicarboxylic acid (AIDA) by chiral ligand-exchange chromatography.
abstract: Chiral ligand-exchange chromatography has been shown to be effective in the resolution and semipreparative separation of 1-aminoindan-1,5-dicarboxylic acid (AIDA) enantiomers. In functional activity experiments, only (S)-AIDA was a potent and mGluR1 subtype selective antagonist.
authors.affiliation: Università degli Studi di Perugia, Dipartimento di Chimica e Tecnologia del Farmaco, Perugia, Italy. natalini@iris.chimfarm.unipg.it
authors.forename: Benedetto
authors.initials: B
authors.lastname: Natalini
authors.forename: Maura
authors.initials: M
authors.lastname: Marinozzi
authors.forename: Katrin
authors.initials: K
authors.lastname: Bade
authors.forename: Roccaldo
authors.initials: R
authors.lastname: Sardella
authors.forename: Christian
authors.initials: C
authors.lastname: Thomsen
authors.forename: Roberto
authors.initials: R
authors.lastname: Pellicciari
mesh_terms: D000818:Animals; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D000432:Methanol / Q000494:pharmacology; D008956:Models, Chemical; D010649:Phenylalanine / Q000737:chemistry; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
chemical_list: C095756:1-aminoindan-1,5-dicarboxylic acid; D018691:Excitatory Amino Acid Antagonists; D007189:Indans; D008024:Ligands; D018094:Receptors, Metabotropic Glutamate; D010649:Phenylalanine; D000432:Methanol