title: Effect of high-salt diet or chronic captopril treatment on exercise capacity in normotensive rats.
abstract: 1. We investigated whether chronic suppression of the renin-angiotensin system, which is known to be associated with reductions in microvascular density and vasodilator responsiveness of skeletal muscle, could affect exercise capacity in normotensive rats. 2. Rats were placed on normal rat chow, normal rat chow with captopril (100 mg/kg per day) or a high-salt diet (HS; 4%) for 4 weeks. Following these interventions, rats with indwelling carotid artery catheters were submitted to stepwise increasing exercise on a motor treadmill at a speed of 10, 20 and 30 m/min for 4 min while blood lactate was measured. 3. Blood lactate after exercise at a speed of 20 m/min was significantly higher and the duration during which rats were able to run at a speed of 30 m/min was significantly shorter in captopril-treated rats and rats fed an HS diet compared with control rats. 4. We conclude that chronic treatment with captopril or HS diet could reduce the exercise capacity in inactive normotensive rats, probably through chronic inhibition of the renin-angiotensin system.
authors.affiliation: Department of Internal Medicine and Rehabilitation Science, Tohoku University Graduate School of Medicine, Sendai, Japan. minaoyo@mail.tains.tohoku.ac.jp
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Minami
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Mori
authors.forename: Makoto
authors.initials: M
authors.lastname: Nagasaka
authors.forename: Taku
authors.initials: T
authors.lastname: Harada
authors.forename: Hajime
authors.initials: H
authors.lastname: Kurosawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kanazawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kohzuki
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002216:Captopril / Q000008:administration & dosage*; D005080:Exercise Test / Q000187:drug effects* / Q000379:methods; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
chemical_list: D017673:Sodium Chloride, Dietary; D002216:Captopril