Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.
P-selectin and P-selectin glycoprotein ligand 1 (PSGL-1) are vascular adhesion molecules that play an important role in leukocyte-endothelial and leukocyte-platelet interaction during the inflammatory response. Their functions are now known to include a role in thrombus formation, specifically in relation to fibrin generation and propagation. Recent findings have demonstrated that leukocyte-derived microparticles, bearing both tissue factor and PSGL-1, circulate in the blood and accumulate in the developing platelet-rich thrombus following vessel wall injury, thus concentrating tissue factor at the site of vascular injury and initiating blood coagulation.
Furie
Bruce
B
Center for Hemostasis, Thrombosis and Vascular Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. bfurie@bidmc.harvard.edu
Furie
Barbara C
BC
D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism*; D002448:Cell Adhesion; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000097:blood*; D008833:Microcirculation; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D019007:P-Selectin / Q000097:blood* / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood* / Q000209:etiology; D013997:Time Factors
D008562:Membrane Glycoproteins; D019007:P-Selectin; C084882:P-selectin ligand protein; D005337:Fibrin; D013925:Thromboplastin