Aspirin use and pancreatic cancer mortality in a large United States cohort.
BACKGROUND
Results from some epidemiologic studies have suggested that aspirin use may reduce risk of pancreatic cancer, but the evidence remains limited.


METHODS
We examined the association between aspirin use and pancreatic cancer mortality among 987 590 U.S. adults in the Cancer Prevention Study II (CPS-II) cohort. CPS-II participants completed a self-administered questionnaire in 1982 and were followed for mortality through 2000. During follow-up, there were 4577 deaths from pancreatic cancer (2434 in men and 2143 in women). We calculated rate ratios (RR) adjusted for age, sex, race, body mass index, diabetes, and cigarette smoking status.


RESULTS
Aspirin use was not associated with pancreatic cancer mortality. The rate ratio associated with aspirin use 30 or more times per month, compared with no use, was 0.97 (95% confidence interval [CI] = 0.86 to 1.09). Even participants who reported both frequent aspirin use (> or =30 times per month) and use for 20 or more years were not at decreased risk compared with nonusers (RR = 0.96, 95% CI = 0.69 to 1.33). We found no association between aspirin use and pancreatic cancer mortality in subgroup analyses by follow-up time, cigarette smoking status, or sex.


CONCLUSIONS
Results from this large prospective study do not support an important effect of aspirin use on pancreatic cancer mortality.
Jacobs
Eric J
EJ
Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30329, USA. eric.jacobs@cancer.org
Connell
Cari J
CJ
Rodriguez
Carmen
C
Patel
Alpa V
AV
Calle
Eugenia E
EE
Thun
Michael J
MJ
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000494:pharmacology*; D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology*; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000517:prevention & control*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012107:Research Design; D011795:Surveys and Questionnaires; D014481:United States / Q000453:epidemiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin