title: Alpha-synuclein and Parkinson's disease.
abstract: Alpha-synuclein (alpha-syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in alpha-syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease (PD). The physiological functions of alpha-syn remain to be fully defined, although recent data suggest a role in regulating membrane stability and neuronal plasticity. Various trigger factors, either environmental or genetic, can lead to a cascade of events involving misfolding or loss of normal function of alpha-syn. In dopaminergic neurons, this may promote a vicious cycle in which elevation in cytoplasmic dopamine, oxidative stress, alpha-syn dysfunction, and disruption of vesicle function lead to dopaminergic cell loss and PD. Alpha-syn dysfunction appears to be a common feature of all forms of PD. The mechanism by which alpha-syn induces neuronal cell toxicity may invoke multiple pathways, such as aggregation or interaction with other proteins and molecules, including synphilin-1, chaperone 14-3-3 protein, and dopamine itself. This complexity has hindered the development of models to study PD. The available animal models of PD, each present distinct advantages and limits. Findings to date suggest that alpha-syn-based models represent a paradigm, which is closest to the human pathology.
authors.affiliation: Department of Pharmacology and Anesthesiology, University of Padova, 35131 Padova, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Recchia
authors.forename: Patrizia
authors.initials: P
authors.lastname: Debetto
authors.forename: Alessandro
authors.initials: A
authors.lastname: Negro
authors.forename: Diego
authors.initials: D
authors.lastname: Guidolin
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Skaper
authors.forename: Pietro
authors.initials: P
authors.lastname: Giusti
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D010300:Parkinson Disease / Q000209:etiology*; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein