title: Interaction between natural killer and dendritic cells: the role of CD40, CD80 and major histocompatibility complex class i molecules in cytotoxicity induction and interferon-gamma production.
abstract: This study focuses on the differential role of CD40 and CD80 costimulatory molecules and major histocompatibility complex class I (MHC-I) antigens in the regulation of the interplay between dendritic cells (DCs) and interleukin (IL)-2-activated human natural killer (NK) lymphocytes. Our data indicate that CD40 and CD80 molecules might play a preferential role in the induction of cytotoxic function but not in the interferon-gamma(IFN-gamma) production by human IL-2-activated NK effectors in the presence of autologous and allogeneic DCs. In addition, a critical role of CD94-dependent MHC-I recognition in the regulation of both IFN-gamma production and target cell lysis was shown in the functional interaction between NK and DCs.
authors.affiliation: Cattedra di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Naples, Italy. terrazza@unina.it
authors.forename: G
authors.initials: G
authors.lastname: Terrazzano
authors.forename: S
authors.initials: S
authors.lastname: Pisanti
authors.forename: S
authors.initials: S
authors.lastname: Grimaldi
authors.forename: M
authors.initials: M
authors.lastname: Sica
authors.forename: S
authors.initials: S
authors.lastname: Fontana
authors.forename: E
authors.initials: E
authors.lastname: Carbone
authors.forename: S
authors.initials: S
authors.lastname: Zappacosta
authors.forename: G
authors.initials: G
authors.lastname: Ruggiero
mesh_terms: D018122:B7-1 Antigen / Q000276:immunology*; D019013:CD40 Antigens / Q000276:immunology*; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism
chemical_list: D018122:B7-1 Antigen; D019013:CD40 Antigens; D015395:Histocompatibility Antigens Class I; D007371:Interferon-gamma