title: Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis.
abstract: Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both developing and mature cartilage. Increasing evidence indicates that the action of numerous chondroregulatory molecules depends on these proteoglycans. This review summarizes the current understanding of the interactions of heparan sulfate chains of cartilage proteoglycans with both soluble and nonsoluble ligands during the process of chondrogenesis. In addition, the consequences of mutating genes encoding heparan sulfate biosynthetic enzymes or heparan sulfate proteoglycan core proteins on cartilage development are discussed.
authors.affiliation: Department of Biological Sciences, University of Delaware, Newark, Delaware, USA. ckirn@udel.edu
authors.forename: Catherine B
authors.initials: CB
authors.lastname: Kirn-Safran
authors.forename: Ronald R
authors.initials: RR
authors.lastname: Gomes
authors.forename: Anissa J
authors.initials: AJ
authors.lastname: Brown
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Carson
mesh_terms: D000818:Animals; D020219:Chondrogenesis; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction
chemical_list: D019812:Heparan Sulfate Proteoglycans