Robust control in bacterial regulatory circuits.
Robust control refers to regulatory systems that are insensitive to perturbations to the intra- or extra-cellular environment. It is generally believed that most cell regulatory circuits should possess some degree of robustness. Examples of robust control and the underlying mechanisms for achieving this robustness are only beginning to be uncovered. Various forms of robustness are associated with circuits based on negative and/or positive feedback, bi-functional enzymes, protein oligomerization and discrete or continuous control.
Goulian
Mark
M
Department of Physics and Institute for Medicine and Engineering, University of Pennsylvania, 209 S. 33rd Street, Philadelphia, PA 19104, USA. goulian@physics.upenn.edu
D001419:Bacteria / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*