[Effect of total triterpenes from Centella asiatica on the depression behavior and concentration of amino acid in forced swimming mice].
OBJECTIVE
To evaluate the antidepressant activity of total triterpenes from Centella asiatica in forced swimming test.


METHODS
Mice were randomly divided into control group, model group and treatment group. The effect of total triterpenes from Centella asiatica on the immobility time in forced swimming mice and concentration of amino acid in mice brain tissue was observed.


RESULTS
Imipramine and total triterpenes from Centella asiatica reduced the immobility time and ameliorated the imbalance of amino acid levels.


CONCLUSIONS
The total triterpenes from Centella asiatica had antidepressant activity.
Chen
Yao
Y
School of Pharmacy, Second Military Medical University, Shanghai 200433.
Han
Ting
T
Qin
Luping
L
Rui
Yaocheng
Y
Zheng
Hanchen
H
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D028041:Centella / Q000737:chemistry*; D003863:Depression / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051379:Mice; D005082:Physical Exertion / Q000187:drug effects; D013550:Swimming; D014315:Triterpenes / Q000494:pharmacology*
D000596:Amino Acids; D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes; D007099:Imipramine