title: [Intractable diarrhoea revealing a neuroblastoma hypersecreting the vasoactive intestinal peptide].
abstract: In children, the watery diarrhoea-hypokalemia-achlorhydria (WDHA) syndrome is uncommon and usually due to a neuroblastic tumour hypersecreting the vasoactive intestinal peptide (VIP). We report a case of WDHA syndrome secondary to hypersecretion of VIP that revealed a neuroblastoma in a 13-month-old girl. A secretory diarrhoea, characterised by the persistence of diarrhoea despite the cessation of oral feeding, led to the search of a neuroblastic tumour in the patient. The serum concentration of VIP decreased to normal values soon after the surgical excision of the tumour.
authors.affiliation: Clinique de pédiatrie, hôpital Jeanne-de-Flandre, 2, avenue Oscar-Lambret, 59037 Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Bourgois
authors.forename: F
authors.initials: F
authors.lastname: Boman
authors.forename: B
authors.initials: B
authors.lastname: Nelken
authors.forename: M
authors.initials: M
authors.lastname: Bonnevalle
authors.forename: D
authors.initials: D
authors.lastname: Turck
mesh_terms: D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis; D014660:Vasoactive Intestinal Peptide / Q000032:analysis* / Q000494:pharmacology; D003969:Vipoma / Q000150:complications* / Q000175:diagnosis
chemical_list: D014660:Vasoactive Intestinal Peptide