3beta,6beta-dihydroxyolean-12-en-27-oic acid: a cytotoxic and apoptosis-inducing oleanane triterpenoid from the rhizome of Astilbe chinensis.
3beta,6beta-dihydroxyolean-12-en-27-oic acid, C(30)H(48)O(4), a cytotoxic and apoptosis-inducing oleanane triterpenoid, which was isolated from the rhizome of Astilbe chinensis, consists of a linear array of five fused six-membered rings. The central ring has a slightly distorted half-chair conformation, while the four outer rings adopt chair conformations. Two hydroxy groups and one carboxy group serve simultaneously as hydrogen-bond donors and acceptors, forming molecular chains.
Sun
Hong Xiang
HX
Department of Chemistry, Zhejiang University, Hangzhou 310027, People's Republic of China.
Pan
Yuan Jiang
YJ
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006801:Humans; D006860:Hydrogen Bonding; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014315:Triterpenes