title: Influence of storage humidity on the in vitro inhalation properties of salbutamol sulfate dry powder with surface covered lactose carrier.
abstract: The influence of storage humidity on the in vitro inhalation properties of salbutamol sulfate dry powder with surface covered lactose carrier was investigated. In the present study, drug/carrier powder mixtures were prepared consisting of micronized salbutamol sulfate and lactose carriers with different particle surface conditions prepared by surface covering. Lactose carrier surfaces were covered with vegetable magnesium stearate (Mg-St-V) by a high-speed elliptical-rotor-type powder mixer (Theta-Composer). These powder mixtures were aerosolized by a Jethaler), and the in vitro inhalation properties of salbutamol sulfate were evaluated by a twin impinger. Compared with the powder mixed with uncovered lactose carrier, the in vitro inhalation properties of the powder mixture prepared using the surface covered lactose carrier were little decreased with increased in relative humidity (RH), showing that the in vitro inhalation properties of salbutamol sulfate were improved at high RH. Using this surface covering technique would thus be valuable for storage humidity of dry powder inhalation (DPI) with lactose carrier particles.
authors.affiliation: Faculty of Pharmacy, Meijo University, Nagoya, Japan. iida@ccmfs.meijo-u.ac.jp
authors.forename: Kotaro
authors.initials: K
authors.lastname: Iida
authors.forename: Youhei
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Okamoto
authors.forename: Kazumi
authors.initials: K
authors.lastname: Danjo
authors.forename: Hans
authors.initials: H
authors.lastname: Luenberger
mesh_terms: D000280:Administration, Inhalation; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004356:Drug Storage; D006813:Humidity; D007785:Lactose; D008274:Magnesium / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D011208:Powders; D013499:Surface Properties
chemical_list: D001993:Bronchodilator Agents; D004337:Drug Carriers; D011208:Powders; D008274:Magnesium; D007785:Lactose; D000420:Albuterol