title: 8-Oxabicyclo[3.2.1]oct-6-en-3-ones: application to the asymmetric synthesis of polyoxygenated building blocks.
abstract: The development and design of reliable and efficient methods for the construction of chiral building blocks are crucial in modern natural product synthesis. 8-Oxabicyclo[3.2.1]oct-6-en-3-ones are readily accessible scaffolds with defined stereochemical features which have been exploited for non-aldol approaches to the preparation of chiral building blocks. Strategies for their enantioselective synthesis, including asymmetric cycloaddition methods, desymmetrization protocols, and "racemic switch operations", are presented and evaluated.
authors.affiliation: Institut für Organische Chemie, Universität Hannover, Schneiderberg 1 B, 30167 Hannover, Germany.
authors.forename: Ingo V
authors.initials: IV
authors.lastname: Hartung
authors.forename: H Martin R
authors.initials: HM
authors.lastname: Hoffmann