title: Protective effects of dietary soy isoflavones against UV-induced skin-aging in hairless mouse model.
abstract: OBJECTIVE
  This study investigated the anti-aging effects of dietary isoflavones on photoaged hairless mouse skin.
  
  
  METHODS
  Female hairless mice were administered soy isoflavone extract orally and irradiated with UV light for four weeks. The effects of the isoflavones on the skin appearance, collagen deposition and epidermal thickness in the UV-damaged mouse skin were measured using bioengineering and histochemical methods. In addition, the influence of the isoflavones on the collagen metabolism in the UVB-irradiated human skin fibroblasts was also investigated.
  
  
  RESULTS
  In the isoflavone treated group, the skin had a better appearance and less wrinkling than that of the control group. Additionally, the amount of collagen deposition was higher in the isoflavone group. In the human fibroblast cells, the amount of procollagen de novo synthesized did not increase after isoflavone treatment and/or UV irradiation. However, the increase in the expression of the metalloproteinases (MMPs) as a result of UV irradiation was suppressed by the isoflavone treatment.
  
  
  CONCLUSIONS
  It appears that isoflavones had an anti-aging effect on the UV-damaged hairless mice model, which is partly due to the inhibitory effects on UV-induced MMP-1 expression and the subsequent collagen degradation.
authors.affiliation: Pharmaceutical & Health Research Institute, AmorePacific Corporation R&D Center, Yongin, Kyounggi, Korea.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Su-Jong
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jin-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Wan-Gi
authors.initials: WG
authors.lastname: Kim
authors.forename: Won-Seok
authors.initials: WS
authors.lastname: Park
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Sim
authors.forename: Sang-Jun
authors.initials: SJ
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002478:Cells, Cultured; D003094:Collagen / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D006801:Humans; D007150:Immunohistochemistry; D007529:Isoflavones / Q000494:pharmacology*; D045726:Metalloproteases / Q000378:metabolism; D051379:Mice; D008812:Mice, Hairless; D011897:Random Allocation; D012867:Skin / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D007529:Isoflavones; D003094:Collagen; D045726:Metalloproteases