Failure to detect DUP25 in lymphoblastoid cells derived from patients with panic disorder and control individuals representing European and American populations.
Investigation of the co-occurrence of panic and phobic disorders with joint laxity led to the identification of interstitial duplications involving human chromosome 15q24-26 (named 'DUP25') in a Spanish population. DUP25 was observed in 97% of patients and in 7% of control individuals. In the present study, we used two different methods to detect DUP25: high-throughput molecular gene dosage analysis and fluorescence in situ hybridization (FISH). We evaluated 56 lymphoblastoid cell lines derived from 26 unrelated patients with panic disorder obtained from several European and American populations and 30 normal controls. We could not find any cell line showing a result consistent with DUP25. These data do not support any association of DUP25 with panic disorder.
Zhu
Guanshan
G
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Bartsch
Oliver
O
Skrypnyk
Cristina
C
Rotondo
Alessandro
A
Akhtar
Longina A
LA
Harris
Claudia
C
Virkkunen
Matti
M
Cassano
Giovanni
G
Goldman
David
D
D000328:Adult; D000368:Aged; D000569:Americas; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15; D005060:Europe; D005260:Female; D018628:Gene Dosage; D020440:Gene Duplication; D005828:Genetics, Population; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000235:genetics*; D020812:Receptor, trkC / Q000235:genetics*; D013030:Spain
D020812:Receptor, trkC