2'-fluoro-2'-deoxycytidine inhibits Borna disease virus replication and spread.
Borna disease virus (BDV) causes neurological diseases in a variety of warm-blooded animal species, possibly including humans. To date, there is no effective treatment against BDV infection. Recently, we reported on the antiviral activity of 1-beta-D-arabinofuranosylcytosine (Ara-C). However, Ara-C's cytotoxic side effects are a major obstacle for its therapeutic use. Herein, we demonstrate that the nucleoside analog 2'-fluoro-2'-deoxycytidine (2'-FdC) exhibits potent antiviral activity against BDV. Importantly, 2'-FdC-associated cytotoxicity is negligible, indicating 2'-FdC as an excellent candidate for the development of antiviral therapy against BDV.
Bajramovic
Jeffrey J
JJ
Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, Paris, France.
Volmer
Romain
R
Syan
Sylvie
S
Pochet
Sylvie
S
Gonzalez-Dunia
Daniel
D
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001890:Borna Disease / Q000821:virology; D001891:Borna disease virus / Q000187:drug effects*; D002522:Chlorocebus aethiops; D003561:Cytarabine / Q000494:pharmacology; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D012367:RNA, Viral / Q000096:biosynthesis / Q000235:genetics; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D012367:RNA, Viral; D003561:Cytarabine; D003841:Deoxycytidine; C007251:2'-fluoro-2'-deoxycytidine