title: Diagnosis and treatment of acromegaly complications.
abstract: The Pituitary Society in conjunction with the European Neuroendocrine Association held a consensus workshop to develop guidelines for diagnosis and treatment of the co-morbid complications of acromegaly. Fifty nine pituitary specialists (endocrinologists, neurosurgeons and cardiologists) assessed the current published literature on acromegaly complications in light of recent advances in maintaining tight therapeutic control of GH hypersecretion. The impact of elevated GH levels on cardiovascular disease, hypertension, diabetes, sleep apnea, colon polyps, bone disease, reproductive disorders, and neuropsychologic complications were considered. Guidelines are proposed for effective management of these complications in the context of overall acromegaly control. When appropriate, requirements for prospective evidence-based studies and surveillance database development are enunciated. Effective management of co-morbid acromegaly complications will lead to improved morbidity and mortality in acromegaly.
authors.affiliation: University of Brescia, Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giustina
authors.forename: F F
authors.initials: FF
authors.lastname: Casanueva
authors.forename: F
authors.initials: F
authors.lastname: Cavagnini
authors.forename: P
authors.initials: P
authors.lastname: Chanson
authors.forename: D
authors.initials: D
authors.lastname: Clemmons
authors.forename: L A
authors.initials: LA
authors.lastname: Frohman
authors.forename: R
authors.initials: R
authors.lastname: Gaillard
authors.forename: K
authors.initials: K
authors.lastname: Ho
authors.forename: P
authors.initials: P
authors.lastname: Jaquet
authors.forename: D L
authors.initials: DL
authors.lastname: Kleinberg
authors.forename: S W J
authors.initials: SW
authors.lastname: Lamberts
authors.forename: G
authors.initials: G
authors.lastname: Lombardi
authors.forename: M
authors.initials: M
authors.lastname: Sheppard
authors.forename: C J
authors.initials: CJ
authors.lastname: Strasburger
authors.forename: M L
authors.initials: ML
authors.lastname: Vance
authors.forename: J A H
authors.initials: JA
authors.lastname: Wass
authors.forename: S
authors.initials: S
authors.lastname: Melmed
mesh_terms: D000172:Acromegaly / Q000150:complications*; D003933:Diagnosis; D006801:Humans; D013812:Therapeutics