Aging changes in the human brain: a histochemical and immunohistochemical study.
There are very few studies on neuropathological changes of aging in the Indian population. In the present study, the incidence of aging changes in 20 non-demented elderly humans above the age of 55 years were observed. The incidence of neurofibrillary tangles (NFT) increased from 20% in 50-55-year-olds to 80% in 55-year-olds and over. Senile plaques (SP) increased from 20% in 50-55-year-olds to 80% in 55-60-year-olds and 40% in 60-year-olds and over. The results of immunohistochemistry to label the NFT (Tau) and SP (beta-amyloid) were comparable to the Bielchowsky's modified silver methanamine method. The incidence of age related changes and their antigenic character in the limited sample studied from north-west India appear to be comparable to those from the southern part of India and Western hemisphere.
Mohanty
Sambit K
SK
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Dr_sambit@hotmail.com
Radotra
Bishan D
BD
Banerjee
Ashru K
AK
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry / Q000473:pathology; D006624:Hippocampus / Q000737:chemistry / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000737:chemistry / Q000473:pathology; D058225:Plaque, Amyloid / Q000737:chemistry / Q000473:pathology