title: Second round results of the Finnish population-based prostate cancer screening trial.
abstract: OBJECTIVE
  Large randomized trials provide the only valid means of quantifying the benefits and drawbacks of prostate-specific antigen (PSA) screening, but the follow-up of ongoing studies is still too short to allow evaluation of mortality. We report here the intermediate indicators of screening efficacy from the second round of the Finnish trial.
  
  
  METHODS
  The Finnish trial, with approximately 80,000 men in the target population, is the largest component in the European Randomized Study of Screening for Prostate Cancer. The first round was completed in 1996-1999. Each year 8,000 men 55-67 years of age were randomly assigned to the screening arm, and the rest formed the control arm. Men randomized to the screening arm in 1996 were reinvited 4 years later, in 2000, and PSA was determined.
  
  
  RESULTS
  Of the eligible 6415 men, 4407 (69%) eventually participated in the second round of screening. Of the first-round participants, up to 84% (3833 of 4556) attended rescreening. A total of 461 screenees (10.5%) had PSA levels of > or = 4 microg/liter. Altogether, 97 cancers were found, yielding an overall detection rate of 2.2% (97 of 4407). Seventy-nine cases were found among the 3833 second-time screenees (detection rate 2.1%) and 18 in those 574 men (3.1%) who had not participated previously. A PSA of > or = 4 microg/liter, but negative biopsy in the first screening round was associated with an up to 9-fold risk of cancer in rescreening relative to those with lower PSA levels at baseline. Ninety-one (94%) of all of the detected cancers were clinically localized.
  
  
  CONCLUSIONS
  As surrogate measures of an effective screening program, both compliance as well as the overall and advanced prostate cancer detection rates remained acceptable. Men defined as screen-positive but with a negative confirmation of cancer at prevalence screen formed a high-risk group at rescreening.
authors.affiliation: Department of Surgery, Seinäjoki Central Hospital, Seinäjoki, Finland. tuuka.makinen@epshp.fi
authors.forename: Tuukka
authors.initials: T
authors.lastname: Mäkinen
authors.forename: Teuvo L J
authors.initials: TL
authors.lastname: Tammela
authors.forename: Ulf-Håkan
authors.initials: UH
authors.lastname: Stenman
authors.forename: Liisa
authors.initials: L
authors.lastname: Määttänen
authors.forename: Jussi
authors.initials: J
authors.lastname: Aro
authors.forename: Harri
authors.initials: H
authors.lastname: Juusela
authors.forename: Paula
authors.initials: P
authors.lastname: Martikainen
authors.forename: Matti
authors.initials: M
authors.lastname: Hakama
authors.forename: Anssi
authors.initials: A
authors.lastname: Auvinen
mesh_terms: D000367:Age Factors; D000368:Aged; D000465:Algorithms; D005387:Finland; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D013997:Time Factors
chemical_list: D017430:Prostate-Specific Antigen