cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization.
DNA/RNA hybridization studies of PNA-T oligomers with cis-(1S,2R/1R,2S)-cyclopentyl units in the backbone show stereochemistry dependent binding with RNA/DNA discrimination.
Govindaraju
T
T
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, 411008, India.
Kumar
Vaijayanti A
VA
Ganesh
Krishna N
KN
D001665:Binding Sites; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013237:Stereoisomerism
D003517:Cyclopentanes; D003521:Cyclopropanes; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA