title: [Surgical treatment of advanced epithelial ovarian cancer].
abstract: Primary cytoreductive surgery remains the standard care in advanced ovarian cancer. Optimal cytoreductive surgery is defined as a residual tumor load less than 1 cm. after operation. The randomized clinical trials showed that interval debulking surgery improved survival in patients who did not undergo optimal primary debulking surgery. The retrospective trials have suggested that the outcome for patients treated with neoadjuvant chemotherapy followed by interval debulking surgery is the same as for patients treated with primary debulking surgery followed by adjuvant chemotherapy. The neoadjuvant chemotherapy should not to be used for clinical practice until the randomized clinical trial carried out by Gynecological Cancer Group of the European Organization for Research and Treatment of Cancer and National Cancer Institute of Canada answers this question. There are no data from randomized trials to show the survival advantage in patients who received second-look operation as compared to those who did not.
authors.affiliation: Clinic of Oncology, Kaunas University of Medicine Hospital, Eiveniu 2, 3007 Kaunas, Lithuania. onko@takas.lt
authors.forename: Arturas
authors.initials: A
authors.lastname: Inciūra
authors.forename: Elona
authors.initials: E
authors.lastname: Juozaityte
authors.forename: Rūta
authors.initials: R
authors.lastname: Nadisauskiene
authors.forename: Vida Marija
authors.initials: VM
authors.lastname: Cigriejiene
authors.forename: Skirmantas
authors.initials: S
authors.lastname: Kajenas
authors.forename: Daiva
authors.initials: D
authors.lastname: Vaitkiene
authors.forename: Laima
authors.initials: L
authors.lastname: Vaidotiene
authors.forename: Andrius
authors.initials: A
authors.lastname: Simavicius
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010535:Laparoscopy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D015201:Meta-Analysis as Topic; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D010052:Ovariectomy; D016032:Randomized Controlled Trials as Topic; D012086:Reoperation; D012189:Retrospective Studies; D024162:Second-Look Surgery; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents