title: Effectiveness of prostaglandin E1 in relieving obstruction in coarctation of the aorta without opening the ductus arteriosus.
abstract: The two main theories regarding the pathogenesis of coarctation of the aorta are the Skodaic hypothesis of ductal tissue constricting the aorta at the level of the insertion of the ductus arteriosus and the flow theory of decreased ascending aortic blood flow in the fetus, which results in associated isthmic narrowing and a localized shelf. To document that ectopic ductal tissue constriction can cause coarctation of the aorta in the absence of a patent ductus arteriosus, we report three cases of infants presenting with critical coarctation who responded to prostaglandin E1 infusion without opening the ductus arteriosus.
authors.affiliation: New York Presbyterian Hospital, Departmetn of Pediatrics, Columbia University, NY 10032, USA. ll202@columbia.edu
authors.forename: L
authors.initials: L
authors.lastname: Liberman
authors.forename: W M
authors.initials: WM
authors.lastname: Gersony
authors.forename: P A
authors.initials: PA
authors.lastname: Flynn
authors.forename: J J
authors.initials: JJ
authors.lastname: Lamberti
authors.forename: R S
authors.initials: RS
authors.lastname: Cooper
authors.forename: T J
authors.initials: TJ
authors.lastname: Stare
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use*; D001017:Aortic Coarctation / Q000188:drug therapy*; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016896:Treatment Outcome
chemical_list: D000527:Alprostadil