title: New cytotoxic naphthopyrane derivatives from Adenaria floribunda.
abstract: Bioassay-guided fractionation of an EtOAc/MeOH extract of Adenaria floribunda young leaves using MCF-7, H-460, and SF-268 cancer cell lines yielded four new active compounds named adenaflorins A-D (1-4). Their chemical structures were determined by spectroscopic means. Adenaflorin A (1) was the most cytotoxic.
authors.affiliation: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panama, Republic of Panama.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Hussein
authors.forename: Icela
authors.initials: I
authors.lastname: Barberena
authors.forename: Todd L
authors.initials: TL
authors.lastname: Capson
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Kursar
authors.forename: Phyllis D
authors.initials: PD
authors.lastname: Coley
authors.forename: Pablo N
authors.initials: PN
authors.lastname: Solis
authors.forename: Mahabir P
authors.initials: MP
authors.lastname: Gupta
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D029561:Lythraceae / Q000737:chemistry*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010176:Panama; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009285:Naphthoquinones; C484835:adenaflorin A