[Alpha-adducin gene G/W460 polymorphism is associated with intracerebral hemorrhage in Chinese].
OBJECTIVE
To explore the association between alpha-adducin (ADD1) G/W460 and intracerebral hemorrhage (ICH) in Chinese.


METHODS
Samples of peripheral blood were collected from 456 patients with ICH diagnosed by CT or MRI from 7 clinical centers in China and 454 age, sex, and geographically matched subjects as controls. The ADD1 G/W460 polymorphism was detected by PCR. Information about prior exposure to various potential risk factors was collected by questionnaire survey.


RESULTS
The distribution of ADD1gene G460W polymorphisms in the ICH patients and controls were in agreement with the Hardy-Weinberg proportion. The prevalence of 460W allele among ICH cases was 82.2%, higher than that in the controls (76.0%, crude odds ratio, 1.46; 95% CI, 1.05 to 2.05). The ADD1 460W allele was still significantly associated with ICH after adjustment for hypertension and other ICH putative risk factors (adjusted odds ratio, 1.38; 95% CI, 1.01 to 1.88).


CONCLUSIONS
Alpha-adducin gene G/W 460 polymorphism is significantly associated with the risk of ICH. This association does not appear to be mediated by established ICH risk factors, specifically hypertension status.
Dou
Xiang-feng
XF
Sino-German Lab for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Science, Beijing 100037, China.
Zhang
Hong-ye
HY
Huang
Xiao-hong
XH
Liu
Xiao-ning
XN
Ju
Zhen-yu
ZY
Sun
Kai
K
Wang
Dao-wen
DW
Liao
Yu-hua
YH
Ma
Ai-qun
AQ
Zhu
Zhi-ming
ZM
Zhao
Bing-rang
BR
Zhao
Ji-zong
JZ
Song
Yan
Y
Zhang
Lu
L
Hui
Ru-tai
RT
D000328:Adult; D000368:Aged; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D000099291:Adducins