title: Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives.
abstract: (+)-Deoxoartemisitene and its C-11, 13 derivatives were synthesized from artemisinic acid via a short and regiospecific process and several derivatives show 10-20 times more in vitro antimalarial activities against Plasmodium falciparum than artemisinin.
authors.affiliation: Department of Chemistry, Yonsei University, Seoul 120-749, South Korea. mjung@yonsei.ac.kr
authors.forename: Mankil
authors.initials: M
authors.lastname: Jung
authors.forename: Kyunghoon
authors.initials: K
authors.lastname: Lee
authors.forename: Hochul
authors.initials: H
authors.lastname: Jung
authors.forename: Howard
authors.initials: H
authors.lastname: Kendrick
authors.forename: Vanessa
authors.initials: V
authors.lastname: Yardley
authors.forename: Simon L
authors.initials: SL
authors.lastname: Croft
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D037621:Artemisinins; C492892:deoxoartemisitene