Multifaceted dialogue between graft and host in neurotransplantation.
Current restorative neurotransplantation research focuses mainly on the potential of the neural graft to replace damaged or missing cell populations and to deliver needed gene products in the form of transgenes. Because of this graft-oriented bias of the procedure, possible dormant regenerative capabilities within the host have been largely underestimated and dismissed as insignificant. This review discusses existing evidence that neural grafts can have stimulating effects on host-intrinsic plasticity that can help regeneration of the mammalian central nervous system. If confirmed, the synergistic interaction between graft and host might substantially enhance our therapeutic possibilities.
Ourednik
Vaclav
V
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, 50011, USA. voured@iastate.edu
Ourednik
Jitka
J
D000818:Animals; D016380:Brain Tissue Transplantation; D002454:Cell Differentiation; D002493:Central Nervous System Diseases / Q000628:therapy; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009417:Nerve Tissue / Q000637:transplantation*; D009473:Neuronal Plasticity / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D019737:Transplants