Assessment of cardiovascular parameters during dental procedures under the effect of benzodiazepines: a double blind study.
The purpose of this study was to evaluate cardiovascular parameters during dental procedures: systolic, diastolic, and mean blood pressures, and heart rate. Nineteen healthy normotensive patients (18-56 years of age) received restorative treatment on three maxillary molars. The patients were continuously monitored by a non-invasive automatic monitor for blood pressure and heart rate during the pre-, trans-, and post-operative periods at the following stages: 15 min prior to anesthesia; during topical anesthesia; during infiltrative anesthesia; for 5 minutes immediately after; during cavity preparation; during restorative procedure; for 10 min after completion. Patients were divided into three groups: A (without pre-medication), B (preceded by 10 mg diazepam), and C (preceded by placebo). All patients received infiltrative anesthesia containing 1.8 mL of 2% lidocaine (36 mg) with epinephrine 1:100,000 (18 microg). There were no changes in the parameters during the clinical procedures. When groups were compared, there were significant differences in diastolic arterial pressures during anesthesia.
Faraco
Fatima Neves
FN
Department of Stomatology, Faculty of Dentistry, University of São Paulo, São Paulo, SP, Brazil. fatimafaraco@terra.com.br
Armonia
Paschoal Laércio
PL
Simone
José Leonardo
JL
Tortamano
Nicolau
N
D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000008:administration & dosage; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003729:Dental Care; D003731:Dental Caries / Q000628:therapy; D003737:Dental Cavity Preparation; D003793:Dental Restoration, Permanent; D003971:Diastole; D003975:Diazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011229:Preanesthetic Medication; D013599:Systole; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D055815:Young Adult
D000779:Anesthetics, Local; D014151:Anti-Anxiety Agents; D010919:Placebos; D014662:Vasoconstrictor Agents; D008012:Lidocaine; D003975:Diazepam; D004837:Epinephrine