Iridoids as allelochemicals and DNA polymerase inhibitors.
Growth inhibitory activities and nutritional indices of catalpol (1), 8-O-acetylharpagide (2), and harpagide (3) were determinated in larvae and adults of Tribolium castaneum, respectively. Compound 1 produced a series of allelochemical effects probably related with the DNA synthesis. This iridoid possessed the highest inhibitory activity against DNA polymerase. Molecular orbital calculations suggest that a pi-pi charge transfer recognition model could explain the action of iridioids toward nucleic acid synthesis.
Pungitore
Carlos R
CR
INTEQUI-CONICET, Laboratorio de Biología Molecular, and Area de Zoología, Facultad de Química Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700-San Luis, Argentina.
Ayub
Maximiliano Juri
MJ
García
Matías
M
Borkowski
Eduardo J
EJ
Sosa
Marta E
ME
Ciuffo
Gladys
G
Giordano
Oscar S
OS
Tonn
Carlos E
CE
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007300:Insect Control; D057888:Iridoid Glucosides; D057889:Iridoid Glycosides; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014231:Tribolium / Q000187:drug effects*
D004791:Enzyme Inhibitors; D005960:Glucosides; D057888:Iridoid Glucosides; D057889:Iridoid Glycosides; D039823:Iridoids; D019384:Nucleic Acid Synthesis Inhibitors; D011714:Pyrans; C078040:catalpol; C077626:8-O-acetylharpagide; C033250:harpagide