New MCRs: the first 4-component reaction leading to 2,4-disubstituted thiazoles.
New organic reactions allow chemical transformations which were previously not possible. Therefore, new reactions are important contributions to the progress in the field of organic synthesis. In this series we describe the design, scope, and limitations of newly-discovered multi-component reactions (MCRs). Herein, a first example of a MCR is introduced which allows general access to the class of 2,4-di- and 2,4,5-trisubstituted thiazoles.
Kolb
Jürgen
J
Morphochem AG, München, Germany.
Beck
Barbara
B
Almstetter
Michael
M
Heck
Stefan
S
Herdtweck
Eberhardt
E
Dömling
Alexander
A
D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry*
D013844:Thiazoles