title: Natural course of node-negative breast cancer: high risk-related subgroups.
abstract: This study attempted to evaluate the first-generation prognostic factors in terms of relapse-free interval in 297 node-negative breast cancer patients treated with locoregional therapy alone. Predictors of outcome were, in order of strength: tumor size (RR 2.09), tumor grade (RR 2.03) and age (RR 0.97). Age was a single independent prognostic parameter in premenopausal patients younger than 45 (RR 0.82). Tumor size was also a single independent prognostic parameter in middle-aged patients (RR 2.05). In older patients, aged 60 and over, tumor grade (RR 11.6) and type (RR 0,52) in addition to tumor size (RR 7.00) were independent prognostic parameters. Our study of disease-free survival identified high risk-related subgroups: patients younger than 35, middle-aged post-menopausal patients bearing pT2 carcinoma with steroid receptor content lower than 5 fmol/mg, and patients older than 59 bearing pT2 carcinoma with grade 11 and unfavorable types-ductal, lobular.
authors.affiliation: Dept. of Experimental Oncology, Institute of Oncology and Radiology of Serbia, Belgrade, Yugoslavia. dragicavn@ncrc.ac.yu
authors.forename: D
authors.initials: D
authors.lastname: Nikolić-Vukosavljević
authors.forename: K
authors.initials: K
authors.lastname: Kanjer
authors.forename: M
authors.initials: M
authors.lastname: Markicević
authors.forename: N
authors.initials: N
authors.lastname: Todorović-Raković
authors.forename: D
authors.initials: D
authors.lastname: Vukotić
authors.forename: Z
authors.initials: Z
authors.lastname: Nesković-Konstantinović
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology* / Q000503:physiopathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012307:Risk Factors; D013256:Steroids / Q000378:metabolism; D015996:Survival Rate
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D013256:Steroids