title: Case of complete recovery of pancytopenia after treatment of hypopituitarism.
abstract: We describe a 55-year-old woman who presented with pancytopenia with a normocytic and normochromic anemia which was progressive despite conventional treatments such as folic acid, vitamin B6, and oxymetholone. Her physical findings and history of a previous massive postpartum hemorrhage suggested Sheehan's syndrome, and the pituitary hormonal studies revealed panhypopituitarism. After 4 months of thyroxine and glucocorticoid replacement therapy, her pancytopenia and bone marrow hypoplasia recovered completely. Pancytopenia is a rare manifestation of a hormonal abnormality, but hematologists need to be aware of panhypopituitarism as a differential diagnosis when women showing features of hypopituitarism present with pancytopenia because it can be reversed with adequate hormone replacement.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Yongon-dong, Jongro-gu, 110-744, Seoul, Korea.
authors.forename: Dae-Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Park
authors.forename: Kyung Hae
authors.initials: KH
authors.lastname: Jung
authors.forename: Hee Sun
authors.initials: HS
authors.lastname: Chung
authors.forename: Soo
authors.initials: S
authors.lastname: Shin
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yun
authors.forename: Seonyang
authors.initials: S
authors.lastname: Park
authors.forename: Byoung Kook
authors.initials: BK
authors.lastname: Kim
mesh_terms: D000740:Anemia / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D001855:Bone Marrow Diseases / Q000209:etiology; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010198:Pancytopenia / Q000209:etiology*; D012658:Sella Turcica / Q000473:pathology; D013974:Thyroxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D013974:Thyroxine