The first biosynthetic studies of the azinomycins: acetate incorporation into azinomycin B.
13C-labelled acetate efficiently labels the antitumour natural product azinomycin B, revealing a polyketide origin for the naphthoate fragment, that threonine is the probable precursor of the enol fragment, and that alpha-ketoglutarate is a probable precursor of the aziridine fragment.
Corre
Christophe
C
School of Biological and Chemical Sciences, University of Exeter, Exeter EX4 4QD, UK.
Lowden
Philip A S
PA