RNA silencing in viral infections: insights from poliovirus.
RNA interference or RNA silencing is a dsRNA guided mechanism that mediates sequence specific degradation of RNA. The recent demonstration that RNA interference can be used to inhibit virus replication has initiated an exciting field of research: first, as a potential novel antiviral therapeutic approach and, second, as a tool for dissecting virus-host interactions. Here we review and discuss the current data and perspectives on the use of RNA interference in the study of poliovirus as a model for positive strand RNA viruses.
Saleh
Maria-Carla
MC
Department of Microbiology and Immunology, University of California, 513 Parnassus Avenue, Box 0414, San Francisco, CA 94143-2280, USA.
Van Rij
Ronald P
RP
Andino
Raul
R
D000818:Animals; D015967:Gene Expression Regulation, Viral; D006801:Humans; D017955:Poliovirus / Q000235:genetics / Q000502:physiology*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics / Q000502:physiology*; D014777:Virus Diseases / Q000517:prevention & control / Q000628:therapy / Q000821:virology; D014779:Virus Replication / Q000235:genetics
D034741:RNA, Small Interfering