title: Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1.
abstract: The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T, or NK cells. IFN-alpha/beta and IFN-gamma cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.
authors.affiliation: Institute of Virology, University of Zurich, Zurich, Switzerland.
authors.forename: Sabine
authors.initials: S
authors.lastname: Vollstedt
authors.forename: Susi
authors.initials: S
authors.lastname: Arnold
authors.forename: Cornelia
authors.initials: C
authors.lastname: Schwerdel
authors.forename: Marco
authors.initials: M
authors.lastname: Franchini
authors.forename: Gottfried
authors.initials: G
authors.lastname: Alber
authors.forename: James P
authors.initials: JP
authors.lastname: Di Santo
authors.forename: Mathias
authors.initials: M
authors.lastname: Ackermann
authors.forename: Mark
authors.initials: M
authors.lastname: Suter
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002494:Central Nervous System Infections / Q000276:immunology / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D007372:Interferons / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008565:Membrane Proteins; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology; D000096743:Interferon gamma Receptor
chemical_list: D004279:DNA, Viral; D007372:Interferons; D008565:Membrane Proteins; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor