Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
Jo
Young-Il
YI
Division of Nephrology, Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.
Yoon
Jae-Ho
JH
Shin
Sang-Youl
SY
Chang
Won-Chul
WC
Kim
Byung-Kook
BK
Jin
Choon-Jo
CJ
Song
Jong-Oh
JO
D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002408:Catheters, Indwelling / Q000382:microbiology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory; D013203:Staphylococcal Infections / Q000188:drug therapy; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor; D014640:Vancomycin