title: Timing of regional left ventricular lengthening by pulsed tissue Doppler.
abstract: Pulsed tissue Doppler can measure myocardial velocities with high temporal resolution. Our aim was to determine the onset timing of the regional left ventricular longitudinal early lengthening (e) in relation to the mitral inflow (E) in acute coronary syndromes. We applied pulsed tissue Doppler to the septal, lateral, inferior, and anterior left ventricular basal walls of 160 patients with acute coronary syndromes and 60 control subjects. Maximum systolic and early diastolic velocities were lower for patient than for control walls (6.1 +/- 1.7 vs 7.9 +/- 1.4 cm/s, P <.0001, and 6.9 +/- 2.3 vs 10.0 +/- 2.3 cm/s, P <.0001, respectively) and e started later than E (12 +/- 30 vs 2 +/- 19 milliseconds later, P <.0001). All 3 variables related to the degree of visual left ventricular wall pathology. The intraindividual time range for all 4 e starts was wider for patients (43 +/- 27 vs 30 +/- 18 milliseconds, P <.0001). Our results show that pulsed tissue Doppler can identify a delayed and asynchronous initial wall lengthening in acute coronary syndromes.
authors.affiliation: Department of Clinical Physiology, Göteborg University, Sahlgrenska University Hospital, Sweden. c.wallentin@home.se
authors.forename: Cecilia Wallentin
authors.initials: CW
authors.lastname: Guron
authors.forename: Marianne
authors.initials: M
authors.lastname: Hartford
authors.forename: Anita
authors.initials: A
authors.lastname: Persson
authors.forename: Johan
authors.initials: J
authors.lastname: Herlitz
authors.forename: Dag
authors.initials: D
authors.lastname: Thelle
authors.forename: Kenneth
authors.initials: K
authors.lastname: Caidahl
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000503:physiopathology; D015588:Observer Variation; D013318:Stroke Volume / Q000502:physiology; D013548:Sweden / Q000453:epidemiology; D013577:Syndrome; D013997:Time Factors