title: How does a normal human cell become a cancer cell?
abstract: The mechanism by which cells become cancerous has been studied in several different species and cell types. Here, we will focus on the mechanism by which a normal human cell becomes a cancer cell and specifically discuss genes that researchers have used to transform cells. Studying how those genes affect cellular immortalization and transformation will help researchers understand more about cancer biology, find new treatments for cancer and/or improve cell survival during gene therapy.
authors.affiliation: Center for NeuroVirology and Cancer Biology, Dept. of Biology, Temple University, Philadelphia, PA 19122, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Gan
authors.forename: M
authors.initials: M
authors.lastname: Macaluso
authors.forename: C
authors.initials: C
authors.lastname: Cinti
authors.forename: K
authors.initials: K
authors.lastname: Khalili
authors.forename: A
authors.initials: A
authors.lastname: Giordano
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D013539:Simian virus 40 / Q000235:genetics / Q000378:metabolism; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D019098:Telomerase; D018631:ras Proteins