The Coapsys device to treat functional mitral regurgitation: in vivo long-term canine study.
OBJECTIVE
We evaluated the capability of the Myocor Coapsys device (Myocor, Inc, Maple Grove, Minn) to reduce functional mitral regurgitation in a canine model of dilated cardiomyopathy.


METHODS
Functional mitral regurgitation with heart failure was induced in 7 dogs by rapid ventricular pacing. The Coapsys device, which consists of anterior and posterior epicardial pads connected by a subvalvular chord, was then implanted. Heart failure was maintained by continued pacing for 8 weeks. Hemodynamic and echocardiographic measurements were performed at pre- and postsizing and after 8 weeks. The Coapsys subvalvular chord was cut to verify that maintenance of valve competency was due to the device.


RESULTS
All implants were performed off-pump without atriotomy. Mitral regurgitation was reduced in all animals; mean mitral regurgitation grade was reduced from 2.9 +/- 0.7 to 0.7 +/- 0.8 (P =.00005) and was maintained at 0.8 +/- 0.8 after 8 weeks, without hemodynamic compromise or structural damage to the mitral valve. Mitral regurgitation returned to 3.6 +/- 0.8 (P =.102 versus presizing) after cutting the Coapsys subvalvular chord.


CONCLUSIONS
The Coapsys device consistently and chronically reduced functional mitral regurgitation. This device is in clinical trials in the United States.
Inoue
Masahiro
M
Department of Bioengineering, The Cleveland Clinic Foundation, Ohio 44195, USA.
McCarthy
Patrick M
PM
Popović
Zoran B
ZB
Doi
Kazuyoshi
K
Schenk
Soren
S
Nemeh
Hassan
H
Ootaki
Yoshio
Y
Kopcak
Michael W
MW
Dessoffy
Raymond
R
Thomas
James D
JD
Fukamachi
Kiyotaka
K
D000818:Animals; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D003971:Diastole / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D004452:Echocardiography; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006353:Heart-Assist Devices; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D008955:Models, Cardiovascular; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D013995:Time; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery