title: Altered fractionated radiotherapy in the management of head and neck carcinomas: advantages and limitations.
abstract: OBJECTIVE
  This article provides an overview of randomized studies of altered fractionated radiotherapy (RT) in Head and Neck squamous cell carcinoma.
  
  
  RESULTS
  Both hyperfractionated RT and accelerated RT may improve tumor control probability as compared to conventional RT, along with increased but manageable toxicity and a modest improvement in survival.
  
  
  CONCLUSIONS
  Altered RT is a tool that can improve the results obtained with conventional RT in Head and squamous cell carcinoma.
authors.affiliation: Institut Gustave Roussy, Radiation Oncology & Statistic Departments, Villejuif, France. bourhis@igr.fr
authors.forename: Jean
authors.initials: J
authors.lastname: Bourhis
authors.forename: Atoussa
authors.initials: A
authors.lastname: Etessami
authors.forename: Pierre
authors.initials: P
authors.lastname: Wilbault
authors.forename: Antoine
authors.initials: A
authors.lastname: Lusinchi
authors.forename: Gilles
authors.initials: G
authors.lastname: Calais
authors.forename: Michel
authors.initials: M
authors.lastname: Lapeyre
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Pignon
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D019468:Disease Management; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000628:therapy*; D006801:Humans; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D015996:Survival Rate