Kinetic resolution and unusual regioselectivity in palladium-catalyzed allylic alkylations with a chiral P,S ligand.
Effective kinetic resolutions of acyclic allylic acetates and benzoates have been obtained using a palladium/(S)-BINAP(S) catalyst system. Unusually large preferences for the formation of branched alkylation products from 3-but-2-enyl and crotyl substrates have been observed. [reaction: see text]
Faller
J W
JW
Department of Chemistry, Yale University, New Haven, CT 06520, USA. jack.faller@yale.edu
Wilt
Jeremy C
JC
Parr
Jonathan
J