Discorhabdins I and L, cytotoxic alkaloids from the sponge Latrunculia brevis.
Two cytotoxic alkaloids, discorhabdins L (1) and I (2), were isolated from Latrunculia brevis and their structures assigned on the basis of detailed spectroscopic analysis and comparison with the known metabolites discorhabdins R (5), D (6), and B (4). Compounds 1 and 2 showed strong in vitro cytotoxicity against a panel of 14 tumor cell lines.
Reyes
Fernando
F
Drug Discovery Department, PharmaMar S.A. Pol. Ind., La Mina Norte, Avenida de los Reyes 1, 28770 (Colmenar Viejo) Madrid, Spain. jfreyes@pharmamar.com
Martín
Rocío
R
Rueda
Ana
A
Fernández
Rogelio
R
Montalvo
David
D
Gómez
Cristina
C
Sánchez-Puelles
José M
JM
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; D011809:Quinones; C484923:discorhabdin I; C484924:discorhabdin L