Mechanisms in pulmonary toxicology.
Specific accumulation and biotransformation of drugs cause cell injury in the lung. Evoked mechanisms are oxidative injury, direct cytotoxic effects, intracellular deposition of phospholipids, and immune reaction. Individual susceptibility can be due to genetically determined metabolic idiosyncrasy or to immune-mediated hypersensitivity.
Delaunois
Luc M
LM
Division of Pneumology, Université Catholique de Louvain, Cliniques Universitaires de Mont-Godinne, Service de pneumologie, Avenue Therasse 1, B-5530 Yvoir, Belgium. luc.delaunois@pneu.ucl.ac.be
D000276:Adjuvants, Immunologic / Q000009:adverse effects; D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D008168:Lung / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D014945:Wound Healing / Q000502:physiology
D000276:Adjuvants, Immunologic; D003577:Cytochrome P-450 Enzyme System