[Altered higher brain function in PACAP-knockout mice].
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide that functions as not only a neurotransmitter/neuromodulator but also a neurotrophic factor. To assess the roles of endogenous PACAP, several groups including ours have independently produced mice with targeted mutations in the PACAP gene. The phenotypes of the mutant mice both confirm and extend our knowledge of the physiological roles of PACAP in the central nervous system as well as many peripheral organs. In this review, we briefly summarize the roles of PACAP in higher brain function, which have been proposed by the studies using the mutant mice as well as histological and pharmacological approaches.
Shintani
Norihito
N
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan. shintani@phs.osaka-u.ac.jp
Hashimoto
Hitoshi
H
Baba
Akemichi
A
D000818:Animals; D001921:Brain / Q000502:physiology; D004195:Disease Models, Animal; D017774:Long-Term Potentiation; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009479:Neuropeptides / Q000235:genetics* / Q000502:physiology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011596:Psychomotor Disorders / Q000209:etiology*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone / Q000502:physiology; D012098:Reproduction
C495402:Adcyap1 protein, mouse; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone