[Effect of lycopene on blood lipoproteids in women with type 2 diabetes mellitus in postmenopause].
Blind randomized placebo-control research included 39 women. The following criteria were: menopause period for more then 1 year long; diabetes mellitus; arterial hypertension; hypercholesterolemia. The patients were divided into two groups. Women from the first group (N = 24) were given 30 mg lycopene (composed with "Tomatol") per day during 24 weeks. The second group (N = 15) were given placebo. It was showed that during 12-week "Tomatol" intake we state that lycopene concentration in serum increased twice (337.0 +/- 133.0 nM), total cholesterol (CH) and CH LDL decreased by 12% and 16% respectively. The lipoproteins spectrum normalization correlated to serum antioxidative activity (r = 0.30, p < 0.05), and malonic dialdehyde concentration decrease by 44.8% correlated to lycopene increase (r = -0.51, p < 0.05). Our results give us a possibility to use "Tomatol" as an additional medicine for the prevention of atherosclerosis.
Olfer'ev
A M
AM
Il'ina
M V
MV
Berzak
N V
NV
Stetsenko
A V
AV
Olfer'ev
M A
MA
Chudakova
I A
IA
Kapitanov
A B
AB
Shamarin
V M
VM
D000368:Aged; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002338:Carotenoids / Q000008:administration & dosage / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications; D006973:Hypertension / Q000097:blood / Q000150:complications; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D000077276:Lycopene; D017698:Postmenopause / Q000097:blood*; D016896:Treatment Outcome
D000960:Hypolipidemic Agents; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D002338:Carotenoids; D002784:Cholesterol; D000077276:Lycopene