title: Thermal homeostasis and liver transplantation.
abstract: Thermal homeostasis represents the major issue during liver transplantation (OLT) since severe hypothermia may have a deleterious effect on both liver recipient organism and postoperative graft functioning. Because of the known negative influence of hypothermia on intraoperative cardiovascular activity and coagulation system, numerous methods have been suggested to reduce intraoperative heat loss and promote active warming (continuous temperature monitoring, external heat sources, improvement in surgical technique and technologies). A good intraoperative OLT course has an obvious influence on post OLT graft function recovery, but thermal homeostasis has also an essential direct effect on the graft as a constitutive component of conventional cold preservation methods. Hypothermia, however, contributes directly to the graft ischemia-reperfusion injury particularly in marginal and partial organs by several angiogenic mechanisms. For these reasons, on the light of the development of new strategies to increase the donor pool, clinical research is focusing on new preservation methods such as extracorporeal circuits with normothermic oxygenated perfusion.
authors.affiliation: Department of Surgical and Gastroenterological Sciences, University of Padua, School of Medicine, Padova, Italy.
authors.forename: Davide Francesco
authors.initials: DF
authors.lastname: D'Amico
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vitale
authors.forename: Umberto
authors.initials: U
authors.lastname: Cillo
authors.forename: Patrizia
authors.initials: P
authors.lastname: Boccagni
authors.forename: Alberto
authors.initials: A
authors.lastname: Brolese
authors.forename: Giacomo
authors.initials: G
authors.lastname: Zanus
authors.forename: Marco
authors.initials: M
authors.lastname: Bassanello
authors.forename: Umberto
authors.initials: U
authors.lastname: Montin
authors.forename: Enrico
authors.initials: E
authors.lastname: Gringeri
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Amico
authors.forename: Francesco
authors.initials: F
authors.lastname: Ciarleglio
authors.forename: Gianluca
authors.initials: G
authors.lastname: Cappuzzo
authors.forename: Amedeo
authors.initials: A
authors.lastname: Carraro
mesh_terms: D001833:Body Temperature Regulation; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D016031:Liver Transplantation