Healing of severe ulcerative necrobiosis lipoidica with cyclosporin.
A 55-year-old woman with severe, chronic, treatment-resistant ulcerating necrobiosis lipoidica of the shins was commenced on oral cyclosporin at a dose of 2.5 mg/kg/day. Improvement started within 1 week of commencing treatment, and the lesions healed completely over 8 months. Further ulceration occurred 3 months after discontinuing cyclosporin, with improvement on reintroduction of cyclosporin. There have been four previous case reports of healing of treatment-resistant ulcerating necrobiosis lipoidica with cyclosporin.
Stanway
Amy
A
Department of Dermatology, Waikato Hospital, Pembroke Street, Private Bag 2500, Hamilton, New Zealand. malc-amy@ihug.co.nz
Rademaker
Marius
M
Newman
Paul
P
D016572:Cyclosporine / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000188:drug therapy*; D012008:Recurrence; D012883:Skin Ulcer / Q000188:drug therapy; D014945:Wound Healing
D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine