title: Costimulatory molecules and T-cell-B-cell interactions.
abstract: This article focuses on activating and inhibiting costimulatory signals that are delivered to the T cell from antigen-presenting cells, mediating and modulating T-cell clonal expansion and development of effector functions, as well as costimulatory signals that are delivered by activated T cells to interacting target cells. The coordinated expression and interaction of these molecules regulates responses to foreign antigens and avoidance of response to self-antigens. Knowledge of the structure and function of these costimulatory molecules can be used to manipulate immune function and inhibit autoimmunity and inflammation in the setting of disease.
authors.affiliation: Mary Kirkland Center, for Lupus Research, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA. crowm@hss.edu
authors.forename: Mary K
authors.initials: MK
authors.lastname: Crow
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins