Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow transplant.
A patient with chronic phase Philadelphia chromosome positive CML, developed severe protracted bone marrow hypoplasia after interferon therapy. This complication did not respond to two courses of immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and prednisone. The patient continued to be transfusion dependent with persistence of Philadelphia chromosome. Allogeneic BMT restored normal hematopoeisis.
Alabdulaaly
A
A
Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada, M5G 2M9.
Rifkind
J
J
Solow
H
H
Messner
H A
HA
Lipton
J H
JH
D000328:Adult; D001853:Bone Marrow / Q000002:abnormalities*; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000150:complications* / Q000473:pathology / Q000601:surgery*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology; D014184:Transplantation, Homologous
D016898:Interferon-alpha