An efficient synthesis of 2,5-diketopiperazine derivatives by the Ugi four-center three-component reaction.
A facile synthetic approach to 2,5-diketopiperazines 4 by the Ugi four-center three-component reaction using commercially available dipeptides as a bifunctional component, aldehydes, and isocyanides was described.
Cho
Sangwon
S
Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul 130-650, Korea.
Keum
Gyochang
G
Kang
Soon Bang
SB
Han
So-Yeop
SY
Kim
Youseung
Y
D000447:Aldehydes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003486:Cyanides / Q000737:chemistry*; D054659:Diketopiperazines; D004151:Dipeptides / Q000737:chemistry*; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis*
D000447:Aldehydes; D003486:Cyanides; D054659:Diketopiperazines; D004151:Dipeptides; D010879:Piperazines