title: Transcription factor AP-2beta genotype, striatal dopamine D2 receptor density and cerebrospinal fluid monoamine metabolite concentrations in humans.
abstract: Transcription factor AP-2beta has been suggested to influence brain monoaminergic systems by regulating target genes. In order to explore a possible functional role, AP-2beta genotype was analysed in relation to striatal dopamine D2 receptor density determined in vivo by positron emission tomography in human subjects (n = 52). The AP-2beta genotype was also analysed in relation to cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA), 3-methoxy-4-hydroxy-phenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5-HIAA) in healthy human subjects (n = 90). There was no association between the AP-2beta genotype and measures of dopamine receptor density, or CSF 5-HIAA concentrations. However, AP-2beta genotype was associated with CSF-levels of HVA (in women) and MHPG. These data may suggest a functional involvement of AP-2beta in the dopaminergic system, but should be interpreted with caution until replicated.
authors.affiliation: Department of Neuroscience, Section of Pharmacology, Uppsala University, Uppsala, Sweden. mattias.damberg@neuro.uu.se
authors.forename: M
authors.initials: M
authors.lastname: Damberg
authors.forename: C
authors.initials: C
authors.lastname: Berggård
authors.forename: L
authors.initials: L
authors.lastname: Farde
authors.forename: G C
authors.initials: GC
authors.lastname: Sedvall
authors.forename: E G
authors.initials: EG
authors.lastname: Jönsson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001345:Autoradiography; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D003342:Corpus Striatum / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D020891:Raclopride / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012016:Reference Values; D013548:Sweden; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*; D014316:Tritium; D044465:White People
chemical_list: D001679:Biogenic Amines; D004268:DNA-Binding Proteins; D017448:Receptors, Dopamine D2; C493677:TFAP2B protein, human; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D014316:Tritium; D020891:Raclopride; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid