title: Interleukin-17 and the interleukin-17 family member network.
abstract: Interleukin-17 (now known as IL-17A), is a homodimer of two 155 amino acid chains secreted by CD4+ activated memory T cells (CD45+ RO+) and is available as a glycosylated 20- to 30-kDa homodimeric peptide. Human IL-17 shows amino acid sequence identity of 62.5 and 58% to the mouse and rat sequences, respectively. IL-17 can regulate the function of a variety of cell types, plays an important role in the maturation of hematopoietic progenitor cells, and induces production of proinflammatory mediators. Here, for the first time, we summarize the biological effects of IL-17 and its family members as important players of T cell-mediated immune responses and underline the important implications of this cytokine in inflammation and degenerative diseases.
authors.affiliation: Guangxi Institute of Occupational Health, Nanning, China.
authors.forename: Shu-Hai
authors.initials: SH
authors.lastname: Huang
authors.forename: Stavros
authors.initials: S
authors.lastname: Frydas
authors.forename: Duraisamy
authors.initials: D
authors.lastname: Kempuraj
authors.forename: Renato C
authors.initials: RC
authors.lastname: Barbacane
authors.forename: Alfredo
authors.initials: A
authors.lastname: Grilli
authors.forename: William
authors.initials: W
authors.lastname: Boucher
authors.forename: Richard
authors.initials: R
authors.lastname: Letourneau
authors.forename: Bhuvaneshwari
authors.initials: B
authors.lastname: Madhappan
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Papadopoulou
authors.forename: Nicola
authors.initials: N
authors.lastname: Verna
authors.forename: Maria Anna
authors.initials: MA
authors.lastname: De Lutiis
authors.forename: Teresa
authors.initials: T
authors.lastname: Iezzi
authors.forename: Graziano
authors.initials: G
authors.lastname: Riccioni
authors.forename: Theoharis C
authors.initials: TC
authors.lastname: Theoharides
authors.forename: Pio
authors.initials: P
authors.lastname: Conti
mesh_terms: D001847:Bone Diseases / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology / Q000378:metabolism; D020381:Interleukin-17 / Q000276:immunology / Q000502:physiology*; D007410:Intestinal Diseases / Q000276:immunology / Q000378:metabolism; D007592:Joint Diseases / Q000276:immunology / Q000378:metabolism; D007674:Kidney Diseases / Q000276:immunology / Q000378:metabolism; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D020381:Interleukin-17