Effects of hemoperfusion adsorption and/or plasma exchange in treatment of severe viral hepatitis: a comparative study.
OBJECTIVE
Non-bioartificial liver has been applied to clinic for quite a long time, but the reported efficacy has been very different. The aim of this study was to compare the efficacy and safety of hemoperfusion adsorption, plasma exchange and plasma exchange plus hemoperfusion adsorption in treatment of severe viral hepatitis.


METHODS
Seventy-five patients with severe viral hepatitis were treated with hemoperfusion adsorption therapy (24 cases), plasma exchange therapy (17 cases) and plasma exchange plus hemoperfusion adsorption therapy (34 cases). The data of liver function, renal function, blood routine test, prothrombin time (PT) and prothrombin activity (PTa) pre- and post-therapy were analyzed.


RESULTS
Clinical symptoms of patients improved after treatment. The levels of aminotransferase, total bilirubin, direct bilirubin decreased significantly after 3 therapies (P<0.05 or P<0.01). PT, the level of total serum protein decreased significantly and PTa increased significantly after plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy (P<0.05 or P<0.01). The side effects were few and mild in all patients.


CONCLUSIONS
Three therapies were effective in the treatment of severe viral hepatitis. Plasma exchange therapy and plasma exchange plus hemoperfusion adsorption therapy are better than hemoperfusion adsorption therapy.
He
Nian-Hai
NH
Research Institute of Infectious Disease, Southwest Hospital, Third Military Medical University, 29 Gaotanyan Zhengjie, Chongqing 400038, China.
Wang
Ying-Jie
YJ
Wang
Ze-Wen
ZW
Liu
Jun
J
Li
Jia-Jia
JJ
Liu
Guo-Dong
GD
Wang
Yu-Ming
YM
D000328:Adult; D000368:Aged; D005260:Female; D006464:Hemoperfusion; D006525:Hepatitis, Viral, Human / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D012720:Severity of Illness Index; D016060:Sorption Detoxification; D016896:Treatment Outcome