title: [Neuroendocrine pancreatic tumors].
abstract: Neuroendocrine tumors are an interesting group of neoplasmas of the digestive system. A possibility of appearance of syndromes connected with hormonal activity is their common feature. Some of them are not hormonally active and they do not manifest hormonal hyperactivity. The authors present 2 patients with malignant neuroendocrine pancreatic tumors in whom the lack of clinical syndromes connected with overproduction of hormone resulted in the establishment of the diagnosis in an advanced stage of the disease. The tumors were not clinically active but immunohistochemical examinations revealed the presence of hormones in cytoplasmatic granules. Both patients had positive immunostaining for VIP, NSE and chromogranin. Moreover, in one of the patients positive staining for ACTH and glucagon and in another for PGP 9.5 was obtained.
authors.affiliation: Katedry i Kliniki Chirurgii Przewodu Pokarmowego i Chirurgii Ogólnej, Akademii Medycznej we Wrocławiu.
authors.forename: Witold
authors.initials: W
authors.lastname: Knast
authors.forename: Krystyna
authors.initials: K
authors.lastname: Markocka-Maczka
authors.forename: Jerzy
authors.initials: J
authors.lastname: Rabczyński
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
mesh_terms: D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology