The pharmacological treatment of cachexia.
Cachexia is a complex syndrome. The main components of this pathological state are anorexia and metabolic abnormalities such as glucose intolerance, fat depletion, and muscle protein catabolism among others. The aim of the present article is to review the different therapeutic approaches that have been designed to fight and counteract muscle wasting in different pathological states such as cancer, AIDS and chronic heart failure.
Argilés
Josep M
JM
Department de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain. argiles@porthos.bio.ub.es
Almendro
Vanessa
V
Busquets
Sílvia
S
López-Soriano
Francisco J
FJ
D019167:Appetite Stimulants / Q000627:therapeutic use*; D002100:Cachexia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D019247:HIV Wasting Syndrome / Q000188:drug therapy / Q000378:metabolism; D006333:Heart Failure / Q000150:complications / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects
D019167:Appetite Stimulants