title: Nested core collections maximizing genetic diversity in Arabidopsis thaliana.
abstract: The successful exploitation of natural genetic diversity requires a basic knowledge of the extent of the variation present in a species. To study natural variation in Arabidopsis thaliana, we defined nested core collections maximizing the diversity present among a worldwide set of 265 accessions. The core collections were generated based on DNA sequence data from a limited number of fragments evenly distributed in the genome and were shown to successfully capture the molecular diversity in other loci as well as the morphological diversity. The core collections are available to the scientific community and thus provide an important resource for the study of genetic variation and its functional consequences in Arabidopsis. Moreover, this strategy can be used in other species to provide a rational framework for undertaking diversity surveys, including single nucleotide polymorphism (SNP) discovery and phenotyping, allowing the utilization of genetic variation for the study of complex traits.
authors.affiliation: Centre National de Génotypage, 2 rue Gaston Crémieux, 91057 Evry Cedex, France. mckhann@cng.fr
authors.forename: Heather I
authors.initials: HI
authors.lastname: McKhann
authors.forename: Christine
authors.initials: C
authors.lastname: Camilleri
authors.forename: Aurélie
authors.initials: A
authors.lastname: Bérard
authors.forename: Thomas
authors.initials: T
authors.lastname: Bataillon
authors.forename: Jacques L
authors.initials: JL
authors.lastname: David
authors.forename: Xavier
authors.initials: X
authors.lastname: Reboud
authors.forename: Valérie
authors.initials: V
authors.lastname: Le Corre
authors.forename: Christophe
authors.initials: C
authors.lastname: Caloustian
authors.forename: Ivo G
authors.initials: IG
authors.lastname: Gut
authors.forename: Dominique
authors.initials: D
authors.lastname: Brunel
mesh_terms: D017360:Arabidopsis / Q000235:genetics*; D018744:DNA, Plant / Q000235:genetics; D014644:Genetic Variation; D018745:Genome, Plant; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide
chemical_list: D018744:DNA, Plant