title: Transforming growth factor-beta1 (TGF-beta1) in plasma is associated with preeclampsia risk in Peruvian women with systemic inflammation.
abstract: BACKGROUND
  In a case-control study of 100 preeclamptics and 100 controls, we assessed plasma transforming growth factor-beta1 (TGF-beta1) concentrations in relation to preeclampsia risk among Peruvian women with and without systemic inflammation.
  
  
  METHODS
  Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
  
  
  RESULTS
  The OR of preeclampsia increased across quartiles of TGF-beta1 concentrations. Women with elevated TGF-beta1 and a proinflammatory profile experienced the highest risk of preeclampsia (OR = 15.4, 95% CI 4.7-50.4).
  
  
  CONCLUSIONS
  Our results confirm an association between TGF-beta1 and risk of preeclampsia and extend the literature by indicating a strong association in women with systemic inflammation.
authors.affiliation: Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA. Martin.Muy@Swedish.org
authors.forename: Martin
authors.initials: M
authors.lastname: Muy-Rivera
authors.forename: Sixto E
authors.initials: SE
authors.lastname: Sanchez
authors.forename: Surab
authors.initials: S
authors.lastname: Vadachkoria
authors.forename: Chunfang
authors.initials: C
authors.lastname: Qiu
authors.forename: Victor
authors.initials: V
authors.lastname: Bazul
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008423:Maternal Age; D008429:Maternal Welfare; D010568:Peru / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology; D011247:Pregnancy; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I; D012307:Risk Factors; D013223:Statistics as Topic; D016212:Transforming Growth Factor beta / Q000097:blood*; D053773:Transforming Growth Factor beta1
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1