title: [Study on repairing injured middle brain by Schwann cells transplantation].
abstract: OBJECTIVE
  To explore the ability of grafted Schwann cells to promote restore of injured neurons in rat.
  
  
  METHODS
  Schwann cells labeled by BrdU in vitro transplanted into rat middle brain area prior to injure with electric needle stimulus. Immunohistochemistry and image analyzer were used to investigate the expression of BrdU and GAP-43 as well as quantitative analysis respectively.
  
  
  RESULTS
  BrdU positive cells could be identified for up to 8 months and the number increased about 15%, which mainly migrated toward injured ipsilateral cortex. The GAP-43 expression reached its peak one month after transplantation and was significant compared with control group (P < 0.05).
  
  
  CONCLUSIONS
  The transplantation of Schwann cells could promote the restoration of injured neurons.
authors.affiliation: China-Japan Union Hospital, Jilin University, Changchun 130031, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Lin
authors.forename: Qing-san
authors.initials: QS
authors.lastname: Zhu
authors.forename: Fei
authors.initials: F
authors.lastname: Yin
authors.forename: Li
authors.initials: L
authors.lastname: Guo
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D019922:GAP-43 Protein / Q000032:analysis; D007150:Immunohistochemistry; D008636:Mesencephalon / Q000293:injuries / Q000378:metabolism / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D012583:Schwann Cells / Q000378:metabolism / Q000637:transplantation*; D013997:Time Factors
chemical_list: D019922:GAP-43 Protein