title: [Rat model for the multidrug resistant glioma cell line].
abstract: OBJECTIVE
  To evaluate the animal model of the multidrug resistant glioma cell line C6/adr for further in vivo studies.
  
  
  METHODS
  The rat glioma cells C6 and multidrug resistance cells C6/adr were cultured in vitro and implanted into the brain of S-D rats. After implantation, all these animals were examined continually with magnetic resonance imaging (MRI) and histological examination. The growth procedure of intracranial implanted glioma and the survival span of the animal model were evaluated. The statistical analysis was made between the survival data of the two cell lines.
  
  
  RESULTS
  The symptoms of intracranial hypertension did not occur until 4 weeks after inoculation. The MRI findings of the implanted glioma in the rat brain were much earlier than the abnormal behavior observed. Pathological results after inoculation demonstrated the MRI findings. The two cell lines had similar growth characteristics and no significant differences in survival times.
  
  
  CONCLUSIONS
  These results suggest that by means of MRI and histology the growth procedure of the implanted glioma in vivo be successfully observed. All these data will proved to be a useful basis for study of glioma in vivo.
authors.affiliation: Department of Neurosurgery, Second Hospital of Shandong University, Jinan 250033, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Qing-lin
authors.initials: QL
authors.lastname: Zhang
authors.forename: Cheng-wei
authors.initials: CW
authors.lastname: Wang
authors.forename: Tai-fei
authors.initials: TF
authors.lastname: Yu
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Jian-xin
authors.initials: JX
authors.lastname: Kong
authors.forename: Rong-jie
authors.initials: RJ
authors.lastname: Tao
authors.forename: Fu-sheng
authors.initials: FS
authors.lastname: Liu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001932:Brain Neoplasms / Q000473:pathology; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D005910:Glioma / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin