title: Multi-minicore disease with susceptibility to malignant hyperthermia in pregnancy.
abstract: Multi-minicore disease (MmD) is a congenital non-progressive or slowly progressive myopathy associated with multifocal degeneration of muscle fibers. Obstetric management for patients with MmD has not been described previously. A 25-year-old primigravida with a history of muscular weakness from birth was diagnosed with MmD and found to be susceptible to malignant hyperthermia (MH) by muscle biopsy at 28 weeks of gestation. Pregnancy proceeded uneventfully and she had a successful vaginal delivery under sufficient preparation for the possible occurrence of MH. Pregnant women who exhibit myopathic symptoms from childhood should consult an anesthesiologist prior to delivery.
authors.affiliation: Department of Obstetrics and Gynecology, Chiba University Hospital, Chiba University School of Medicine, Chiba, Japan. hosada@mue.biglobe.ne.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Osada
authors.forename: Kentaro
authors.initials: K
authors.lastname: Masuda
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Seki
authors.forename: Souei
authors.initials: S
authors.lastname: Sekiya
mesh_terms: D000328:Adult; D001706:Biopsy; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D006801:Humans; D008305:Malignant Hyperthermia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D020914:Myopathies, Structural, Congenital / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D009246:NADH Tetrazolium Reductase / Q000032:analysis; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012307:Risk Factors
chemical_list: D009246:NADH Tetrazolium Reductase; D002118:Calcium