title: [Relationship between coronary flow reserve and recovery of regional left ventricular function in patients with tako-tsubo-like transient left ventricular dysfunction].
abstract: OBJECTIVE
  This study assessed the relationship between coronary flow reserve and functional recovery of left ventricular wall motion in patients with tako-tsubo-like transient left ventricular dysfunction.
  
  
  METHODS
  Coronary flow reserve was measured using the Doppler guide wire technique in the left descending coronary artery in nine consecutive patients (three men, six women, mean age 71 +/- 11 years) with tako-tsubo-like transient left ventricular dysfunction. Regional wall motion was analyzed to estimate anterior wall motion score index (anterior WMSI) by transthoracic echocardiography on admission and 3 weeks after the onset of symptoms.
  
  
  RESULTS
  Anterior WMSI was 2.2 +/- 0.4 on admission and improved to 1.4 +/- 0.5 at 3 weeks later (p < 0.001). Coronary flow reserve on admission was not correlated to the anterior WMSI on admission (r = 0.19, p = 0.63). However, coronary flow reserve on admission was correlated to the improvement in anterior WMSI (r = 0.74, p = 0.02).
  
  
  CONCLUSIONS
  Coronary microcirculation is damaged in acute phase of tako-tsubo-like transient left ventricular dysfunction. The severity of coronary microvascular dysfunction influences the degree of left ventricular wall motion recovery.
authors.affiliation: Division of Cardiology, Kawasaki Medical School, Matsushima 577, Kurashiki, Okayama 701-0192.
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Kume
authors.forename: Takashi
authors.initials: T
authors.lastname: Akasaka
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kawamoto
authors.forename: Nozomi
authors.initials: N
authors.lastname: Watanabe
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yoshitani
authors.forename: Maki
authors.initials: M
authors.lastname: Akiyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Koyama
authors.forename: Yoji
authors.initials: Y
authors.lastname: Neishi
authors.forename: Miwako
authors.initials: M
authors.lastname: Tsukiji
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D003326:Coronary Circulation; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D012720:Severity of Illness Index; D018608:Ultrasonography, Doppler; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left