[Evaluation of vitamin C and E concentration--some nonenzymatic indicators of antioxidant protective barrier in pregnant women].
Many peroxidation processes taking place in organisms both in normal and pathological conditions are initiated among others by free radicals. Organisms developed many protective mechanisms to fight with detrimental effects of free radical activity. The aim of the study was to evaluate antioxidant protective barrier by determination of concentrations of some non-enzymatic parameters such as L-ascorbic acid and tocopherol in blood plasma, and to correlate assessed values with basic lipoprotein parameters. The study was carried out in 144 pregnant women in the second and third trimester. The subject were divided into four groups: diabetic pregnancy, pregnancy induced hypertension, diabetic pregnancy with hypertension, and healthy pregnant women. The study results show that pregnancy induced hypertension, diabetic pregnancy and diabetic pregnancy with hypertension are the factors which disturb lipoprotein metabolism and may cause atherosclerotic changes. Higher concentrations of alpha-tocopherol and L-ascorbic acid in plasma in diabetic pregnancy with hypertension may be an important factor which adopts woman's organism to oxidation stress in complicated pregnancy.
Bodzek
Piotr
P
Katedry i Oddziału Klinicznego Połoznictwa i Ginekologii w Bytomiu. pbodzek pik-net.pl
Wielkoszyński
Tomasz
T
D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy / Q000097:blood*; D011248:Pregnancy Complications / Q000097:blood*; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D011254:Pregnancy in Diabetics / Q000097:blood; D024505:Tocopherols / Q000097:blood*
D000975:Antioxidants; D015415:Biomarkers; D008074:Lipoproteins; D001205:Ascorbic Acid; D024505:Tocopherols