title: 4-Hydroxynonenal is markedly higher in patients on a standard long-term home parenteral nutrition.
abstract: Parenteral nutrition, a commonly used procedure in patients with gastrointestinal disorders, may lead with time to liver steatosis and fibrosis, whose pathogenesis has yet to be elucidated. Oxidative stress and particularly lipid peroxidation likely contribute to the expression of such hepatobiliary complications, by means of their recognized proinflammatory and profibrogenic effects. To evaluate the adequacy against oxidative insult of a standard micronutrient supplementation in patients under long term parenteral nutrition, a comprehensive patterns of redox indices has been determined on peripheral blood samples from forty one adults in comparison to fifty eight blood donors taken as controls. A sustained oxidative stress in peripheral blood of home parenteral patients was observed. Of the two lipid peroxidation markers found to be markedly increased, namely fluorescent plasma protein adducts with malondialdehyde and 4-hydroxynonenal, respectively, only the second was statistically correlated with all the antioxidant-related changes consistently detected in the patients, namely decreased plasma alpha-tocopherol and selenium intake and higher erythrocyte oxidized glutathione. Plasma level of 4-hydroxynonenal-protein adducts appears to be a reliable and easily measurable marker of oxidative status, particularly indicated to monitor the adequacy of dietary regimen during parenteral nutrition.
authors.affiliation: Clinical Nutrition Center of San Giovanni Battista and of Turin Hospital, Turin, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Massarenti
authors.forename: Fiorella
authors.initials: F
authors.lastname: Biasi
authors.forename: Antonella
authors.initials: A
authors.lastname: De Francesco
authors.forename: Daniela
authors.initials: D
authors.lastname: Pauletto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rocca
authors.forename: Barbara
authors.initials: B
authors.lastname: Silli
authors.forename: Barbara
authors.initials: B
authors.lastname: Vizio
authors.forename: Gaetano
authors.initials: G
authors.lastname: Serviddio
authors.forename: Gabriella
authors.initials: G
authors.lastname: Leonarduzzi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Poli
authors.forename: Augusta
authors.initials: A
authors.lastname: Palmo
authors.forename: Gabriella
authors.initials: G
authors.lastname: Leonarouzzi
mesh_terms: D000328:Adult; D000368:Aged; D000447:Aldehydes / Q000097:blood*; D001205:Ascorbic Acid / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000209:etiology; D007677:Kidney Function Tests; D015227:Lipid Peroxidation; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009752:Nutritional Status; D018384:Oxidative Stress; D016331:Parenteral Nutrition, Home / Q000009:adverse effects* / Q000592:standards; D011237:Predictive Value of Tests; D011506:Proteins / Q000378:metabolism; D012016:Reference Values; D012643:Selenium / Q000097:blood; D014801:Vitamin A / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000447:Aldehydes; D011506:Proteins; D014801:Vitamin A; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D005978:Glutathione; D024502:alpha-Tocopherol; D012643:Selenium; C027576:4-hydroxy-2-nonenal; D001205:Ascorbic Acid