title: A novel method for analysis of TOMROP data.
abstract: OBJECTIVE
  To develop an efficient method for extracting maps of the corrected T1 from images generated using the T One by Multiple Read Out Pulses (TOMROP) sequence.
  
  
  METHODS
  An expression is developed for the true T1 in terms of the parameters from a three-parameter fit of the TOMROP data. Solutions of gadodiamide in normal saline with concentrations of 0.0, 0.06, 0.11, 0.23, 0.46, and 0.91 mM were prepared and T1 measurements were performed using both the inversion recovery (IR) and the TOMROP methods. The TOMROP data were analyzed using the proposed technique and the results compared to those from the IR measurements.
  
  
  RESULTS
  The T1 estimates generated from the TOMROP data using the proposed method were consistent with the IR results. However, systematic errors were observed in the T1 estimates when the repetition time was not sufficient for full recovery of axial magnetization. Relaxation times determined using the proposed method were within 1% of the spectroscopiclly determined values for T1 values in the range of 0.28-2.8 seconds when a suitable delay was employed.
  
  
  CONCLUSIONS
  The proposed method of analysis was found to yield accurate T1 estimates when the assumptions used in the analysis were not violated.
authors.affiliation: Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. radiosp@oasis.rad.upenn.edu
authors.forename: Stephen
authors.initials: S
authors.lastname: Pickup
authors.forename: Andrew K W
authors.initials: AK
authors.lastname: Wood
authors.forename: Harold L
authors.initials: HL
authors.lastname: Kundel
mesh_terms: D003287:Contrast Media; D003627:Data Interpretation, Statistical; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA