title: Successful renal transplantation in children with spina bifida: long term single center experience.
abstract: We report long-term follow up data on cadaveric renal transplantation for end stage renal failure (ESRF) in spina bifida children. Between February 1989 and July 2001, 12 cadaveric renal transplants were performed in 10 children, eight females and two males. Mean age at transplantation was 13.4 yr (range 9-16). Of the patients, eight were wheelchair bound and two were independently mobile. Before transplantation surgical management of the urological tract included, enterocystoplasty and clean intermittent-self catheterization in five patients and ileal conduit urinary diversion in one. A total of eight patients were on renal replacement therapy before receiving the graft while two underwent preemptive transplantation. The 1- and 5-yr graft survival rates were 81 and 81%, respectively. Four grafts failed--two patients have successfully undergone subsequent transplantation. Causes of graft failure were chronic rejection in two, acute rejection and vascular thrombosis in one and vascular thrombosis in one patient, respectively. Two patients died after graft nephrectomy. At a median follow-up of 4.08 yr (range 1 day to 10.65 yr), eight of the 12 grafts are functioning with median serum creatinine of 123 mmol/L (range 65-169). These data demonstrate the feasibility of cadaveric renal transplantation in patients with spina bifida and ESRF. We currently recommend that patients with spina bifida should not be deprived of the benefits of renal transplantation.
authors.affiliation: Urology and Transplantation Department, Beaumont Hospital, Dublin, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Hamdi
authors.forename: P
authors.initials: P
authors.lastname: Mohan
authors.forename: D M
authors.initials: DM
authors.lastname: Little
authors.forename: David P
authors.initials: DP
authors.lastname: Hickey
mesh_terms: D000293:Adolescent; D002102:Cadaver; D002423:Cause of Death; D002648:Child; D003404:Creatinine / Q000097:blood; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D017582:Renal Replacement Therapy; D016135:Spinal Dysraphism / Q000150:complications*; D015996:Survival Rate; D013927:Thrombosis / Q000209:etiology; D016896:Treatment Outcome; D014546:Urinary Catheterization; D014547:Urinary Diversion
chemical_list: D003404:Creatinine