title: [Influence of detomidine on echocardiographic function parameters and cardiac hemodynamics in horses with and without heart murmur].
abstract: 30 warmblood horses were examined before and after sedation with 20 micrograms/kg BW detomidine, to determine changes of cardiac function parameters, using B-mode, M-mode and Doppler echocardiography. 15 horses showed a heart murmur, but no clinical signs of cardiac heart failure, 15 horses had neither a heart murmur nor other signs of cardiac disease. After sedation with detomidine we could recognise a significant increase of end-diastolic left atrium diameter, an increase of end-systolic left ventricular diameter and aortic root diameter. The end-systolic thickness of papillary muscle and interventricular septum showed a decrease. Fractional shortening and amplitude of left ventricular wall motion was decreased after sedation. The mitral valve echogram revealed a presystolic valve closure and an inflection in the Ac slope (B-notch) in xy horses before sedation. Both increased after sedation with detomidine. Doppler echocardiography showed a decrease of blood flow velocity and velocity time integral (VTI) in the left and right ventricular outflow tract after sedation. Regurgitant flow signals were intensified following sedation in xy horses, especially at the mitral valve.
authors.affiliation: Klinik für Pferde, Tierärztliche Hochschule Hannover. heidrun.gehlen@tiho-hannover.de
authors.forename: H
authors.initials: H
authors.lastname: Gehlen
authors.forename: K
authors.initials: K
authors.lastname: Kroker
authors.forename: E
authors.initials: E
authors.lastname: Deegen
authors.forename: P
authors.initials: P
authors.lastname: Stadler
mesh_terms: D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System; D004452:Echocardiography / Q000662:veterinary; D015150:Echocardiography, Doppler / Q000662:veterinary; D005260:Female; D006321:Heart / Q000187:drug effects; D006337:Heart Murmurs / Q000503:physiopathology / Q000662:veterinary*; D006734:Horse Diseases / Q000503:physiopathology*; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine