Biscoumarin: new class of urease inhibitors; economical synthesis and activity.
A variety of biscoumarins (1-21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06-91.35 microM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors.
Khan
Khalid Mohammed
KM
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
Iqbal
Sajid
S
Lodhi
Muhammad Arif
MA
Maharvi
Ghulam Murtaza
GM
Ullah
Zia
Z
Choudhary
Muhammad Iqbal
MI
Rahman
Atta-Ur
AU
Perveen
Shahnaz
S
D003374:Coumarins / Q000138:chemical synthesis* / Q000191:economics / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000191:economics / Q000494:pharmacology; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
D003374:Coumarins; D004791:Enzyme Inhibitors; C030123:coumarin; D014510:Urease