title: Outcome of critical foot ischaemia in longstanding diabetic patients: a retrospective cohort study in a specialised tertiary care centre.
abstract: BACKGROUND
  We sought to establish risk factors predicting the outcome of foot lesions in longstanding diabetic patients with critical foot ischaemia (CFI).
  
  
  METHODS
  We investigated retrospectively 98 consecutive diabetic patients with ischaemic foot lesions. The patients (mean age 70 years, duration of diabetes 21 years) were jointly cared for by specialised diabetologists and vascular surgeons; 75 patients were treated by arterial revascularisation.
  
  
  RESULTS
  Good outcome (lesions healing) was observed in 53 patients (54%). Bad outcome was observed in 45 patients: not healing lesions (n = 5), major amputation (n = 19), and death in relation to the foot lesion (n = 21). Patients with good and bad outcome did not differ regarding age, sex, smoking status, type, duration and treatment of diabetes mellitus, presence of neuropathy, coronary heart disease, stroke, previous amputations, current revascularization, and localization of the foot lesion. The risk of bad outcome was increased 8.9 times in patients on dialysis for end-stage renal disease; 7.0 times if surgical complications were present; and 5.4 times with C-reactive protein (CRP) above the second quintile (cut-off value 8 mg/dl).
  
  
  CONCLUSIONS
  Management of longstanding diabetic patients with ischaemic foot lesions leaves room for improvement. Dialysis treatment, elevated CRP levels and surgical complications were strongly predictive of non-healing lesions, major amputation and death.
authors.affiliation: Department of Metabolic Diseases and Nutrition (WHO Collaborating Centre for Diabetes), Heinrich-Heine University, Düsseldorf, Germany. avolaco@yahoo.com.br
authors.forename: A
authors.initials: A
authors.lastname: Volaco
authors.forename: E
authors.initials: E
authors.lastname: Chantelau
authors.forename: B
authors.initials: B
authors.lastname: Richter
authors.forename: B
authors.initials: B
authors.lastname: Luther
mesh_terms: D000368:Aged; D000671:Amputation, Surgical; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D003925:Diabetic Angiopathies / Q000175:diagnosis* / Q000601:surgery; D003928:Diabetic Nephropathies / Q000150:complications / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000098:blood supply*; D006801:Humans; D007511:Ischemia / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011183:Postoperative Complications / Q000175:diagnosis; D006435:Renal Dialysis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein