Coronalon: a powerful tool in plant stress physiology.
Coronalon, a synthetic 6-ethyl indanoyl isoleucine conjugate, has been designed as a highly active mimic of octadecanoid phytohormones that are involved in insect and disease resistance. The spectrum of biological activities that is affected by coronalon was investigated in nine different plant systems specifically responding to jasmonates and/or 12-oxo-phytodienoic acid. In all bioassays analyzed, coronalon demonstrated a general strong activity at low micromolar concentrations. The results obtained showed the induction of (i) defense-related secondary metabolite accumulation in both cell cultures and plant tissues, (ii) specific abiotic and biotic stress-related gene expression, and (iii) root growth retardation. The general activity of coronalon in the induction of plant stress responses together with its simple and efficient synthesis suggests that this compound might serve as a valuable tool in the examination of various aspects in plant stress physiology. Moreover, coronalon might become employed in agriculture to elicit plant resistance against various aggressors.
Schüler
Göde
G
Max-Planck-Institut für Chemische Okologie, Hans-Knöll-Str. 8, D-07745 Jena, Germany.
Mithöfer
Axel
A
Baldwin
Ian T
IT
Berger
Susanne
S
Ebel
Jürgen
J
Santos
Jonathan G
JG
Herrmann
Gabriele
G
Hölscher
Dirk
D
Kramell
Robert
R
Kutchan
Toni M
TM
Maucher
Helmut
H
Schneider
Bernd
B
Stenzel
Irene
I
Wasternack
Claus
C
Boland
Wilhelm
W
D002478:Cells, Cultured; D003517:Cyclopentanes / Q000145:classification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D017343:Genes, Plant; D007532:Isoleucine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D015394:Molecular Structure; D054883:Oxylipins; D063245:Plant Development; D010937:Plant Growth Regulators / Q000494:pharmacology; D018521:Plant Physiological Phenomena; D018517:Plant Roots / Q000187:drug effects / Q000502:physiology; D010944:Plants / Q000187:drug effects*; D013329:Structure-Activity Relationship
D003517:Cyclopentanes; D005231:Fatty Acids, Unsaturated; D054883:Oxylipins; D010937:Plant Growth Regulators; C484935:coronalon; D007532:Isoleucine; C025999:12-oxophytodienoic acid; C086299:jasmone