Thiourea-catalyzed enantioselective hydrophosphonylation of imines: practical access to enantiomerically enriched alpha-amino phosphonic acids.
Chiral thiourea 1b catalyzes the highly enantioselective hydrophosphonylation of a wide range of N-benzyl imines. The hydrophosphonylation products are readily deprotected by hydrogenolysis, providing access to free alpha-amino phosphonic acids in highly enantioenriched form.
Joly
Guy D
GD
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Jacobsen
Eric N
EN