title: Disruption of estrogen receptor beta in mice brain results in pathological alterations resembling Alzheimer disease.
abstract: OBJECTIVE
  To study the pathological characteristics of the mice with estrogen receptor beta (ER beta) disruption in brain.
  
  
  METHODS
  Immunohistochemistry method was applied in the study.
  
  
  RESULTS
  beta-Amyloid peptide(A beta (42)) and apolipoprotein E (ApoE) immunoreactive substances were accumulated notably in cortex and limbic structures such as the hippocampus and amygdala in brain, resembling the pathological changes of human Alzheimer disease(AD). A beta formed cloudy-like deposits in parenchyma of brain, while apoE also deposited along or surrounding the blood vessels.
  
  
  CONCLUSIONS
  ER beta is crucial to the development of neural degenerative disease, so modulation of A beta metabolism via ER beta signal pathway might be beneficial for AD prevention or therapy.
authors.affiliation: Department of Physiology, Institute of Basic Medical Science,The Fourth Military Medical University, Xi-an 710032, Shaanxi, China. z_qinghong@hotmail.com
authors.forename: Qing-hong
authors.initials: QH
authors.lastname: Zhang
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Huang
authors.forename: Yu-zhen
authors.initials: YZ
authors.lastname: Hu
authors.forename: Gemg-ze
authors.initials: GZ
authors.lastname: Wei
authors.forename: Xue-feng
authors.initials: XF
authors.lastname: Han
authors.forename: Shun-yan
authors.initials: SY
authors.lastname: Lu
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Zhao
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000679:Amygdala / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism*; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000378:metabolism*; D047629:Estrogen Receptor beta; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D058225:Plaque, Amyloid / Q000473:pathology; D011960:Receptors, Estrogen / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen