title: Assessment of myocardial infarction in pigs using a rapid clearance blood pool contrast medium.
abstract: Delayed enhancement MRI using extracellular contrast media allows reliable detection of myocardial infarction. If blood pool contrast media like P792 (Vistarem, Guerbet, France), in addition to improving coronary MR angiography, can be shown to also produce delayed enhancement in myocardial infarction they could improve the prerequisites for a comprehensive cardiac MR examination. In this study reperfused myocardial infarction in five minipigs was imaged with an inversion-recovery fast low-angle shot sequence using P792 (0.013 mmol Gd/kg) and the extracellular contrast medium Gd-DOTA (Dotarem, 0.1 mmol Gd/kg, Guerbet). The infarction size determined on MRI using P792 (7.55 +/- 2.31 cm(2)) highly correlated both with histomorphometry (7.81 +/- 2.18 cm(2), r = 0.991, P < 0.002) and with MRI using Gd-DOTA (7.85 +/- 2.35 cm(2), r = 0.978, P < 0.005). Bland-Altman analysis showed that the limit of agreement of MRI using P792 compared to histomorphometry was 3.3 +/- 7.6% of the infarction size. The contrast-to-noise ratio between infarcted and remote myocardium was not significantly different between Gd-DOTA (5.9 +/- 2.4) and P792 (4.4 +/- 1.1, P = 0.5). The blood pool contrast medium P792 allows reliable assessment of viability with good contrast and accuracy.
authors.affiliation: Department of Radiology, Charité, Medical School, Freie Universität und Humboldt-Universität zu Berlin, Germany. marc.dewey@charite.de
authors.forename: Marc
authors.initials: M
authors.lastname: Dewey
authors.forename: Nicola
authors.initials: N
authors.lastname: Kaufels
authors.forename: Michael
authors.initials: M
authors.lastname: Laule
authors.forename: Jörg
authors.initials: J
authors.lastname: Schnorr
authors.forename: Susanne
authors.initials: S
authors.lastname: Wagner
authors.forename: Dietmar
authors.initials: D
authors.lastname: Kivelitz
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Raynaud
authors.forename: Philippe
authors.initials: P
authors.lastname: Robert
authors.forename: Bernd
authors.initials: B
authors.lastname: Hamm
authors.forename: Matthias
authors.initials: M
authors.lastname: Taupitz
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics; D003331:Coronary Vessels / Q000473:pathology; D006571:Heterocyclic Compounds / Q000097:blood; D007089:Image Enhancement / Q000379:methods*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000097:blood; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000473:pathology; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds / Q000097:blood; D011897:Random Allocation; D015203:Reproducibility of Results; D013552:Swine; D013556:Swine, Miniature
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D008536:Meglumine; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; C072417:gadoterate meglumine; C435266:contrast agent P792