title: PhoP can activate its target genes in a PhoQ-independent manner.
abstract: The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association.
authors.affiliation: Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, 2000 Rosario, Argentina.
authors.forename: Sergio
authors.initials: S
authors.lastname: Lejona
authors.forename: María Eugenia
authors.initials: ME
authors.lastname: Castelli
authors.forename: María Laura
authors.initials: ML
authors.lastname: Cabeza
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Kenney
authors.forename: Eleonora
authors.initials: E
authors.lastname: García Véscovi
authors.forename: Fernando C
authors.initials: FC
authors.lastname: Soncini
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D010766:Phosphorylation; D011485:Protein Binding; D019779:Salmonella enterica / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C079792:PhoQ protein, Bacteria; D014157:Transcription Factors; C061064:PhoP protein, Bacteria