title: [Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice].
abstract: OBJECTIVE
  To identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice.
  
  
  METHODS
  We detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining.
  
  
  RESULTS
  Expression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes.
  
  
  CONCLUSIONS
  The results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.
authors.affiliation: Department of Immunology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Zhang
authors.forename: Qing-li
authors.initials: QL
authors.lastname: Kong
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Chuan
authors.initials: C
authors.lastname: Qin
authors.forename: Wei
authors.initials: W
authors.lastname: He
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D016173:Macrophage Colony-Stimulating Factor