Bacterial invasion: the paradigms of enteroinvasive pathogens.
Invasive bacteria actively induce their own uptake by phagocytosis in normally nonphagocytic cells and then either establish a protected niche within which they survive and replicate, or disseminate from cell to cell by means of an actin-based motility process. The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection.
Cossart
Pascale
P
Unité des Interactions Bactéries-Cellules, INSERM Unité 604, Département de Biologie Cellulaire et Infection, Institut Pasteur, 28 Rue du Docteur Roux, Paris 75015, France. pcossart@pasteur.fr
Sansonetti
Philippe J
PJ
D000199:Actins / Q000502:physiology; D000818:Animals; D001419:Bacteria / Q000254:growth & development / Q000472:pathogenicity*; D001422:Bacterial Adhesion; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000378:metabolism; D003600:Cytosol / Q000382:microbiology; D004755:Enterobacteriaceae / Q000472:pathogenicity* / Q000502:physiology; D004847:Epithelial Cells / Q000382:microbiology* / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology* / Q000502:physiology; D008089:Listeria monocytogenes / Q000472:pathogenicity* / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009068:Movement; D010587:Phagocytosis; D010588:Phagosomes / Q000382:microbiology / Q000502:physiology; D014617:Vacuoles / Q000382:microbiology
D000199:Actins; D001426:Bacterial Proteins