title: Omentopexy improves vascularization and decreases stricture formation of esophageal anastomoses in a dog model.
abstract: BACKGROUND
  Anastomotic strictures are common after primary esophageal anastomosis in pediatric patients. Recent studies provided evidence that omentopexy may improve vascularization of gastroesophageal anastomoses and decrease the rate of stricture-related complications. The effect of omentopexy on primary esophago-esophageal anastomosis, however, is unknown. The aim of the current study was to examine the role of omentopexy on the healing process of primary midesopageal anastomoses.
  
  
  METHODS
  Six dogs were operated on. A 5-cm portion of the midesophagus was resected, and continuity was restored by end-to-end anastomosis. In 3 dogs, an omental pedicle was placed around the anastomotic region. Eating patterns were recorded and functional swallowing was evaluated by fluoroscopic studies. Eight weeks after the operations, the experimental animals were killed and anastomotic lumen diameters and vascularization of the anastomotic sites were evaluated by radiographic studies and histologic examination, respectively.
  
  
  RESULTS
  Two dogs in the omentopexy group were able to resume regular feeding, whereas none of the dogs in the control group were able to tolerate solid food intake. Fluoroscopic studies found preserved motility patterns of the esophagus in the omentoesophagopexy group, while prestenotic dilatation and delayed food clearance through the anastomosis were observed in the control group. Histologically, neovascularization was observed at the anastomotic site in the omentoesophagopexy group in contrast to the marked degree of fibrosis displayed in the control group.
  
  
  CONCLUSIONS
  Omentopexy may improve vascularization and decrease stricture formation after primary esophagoesophageal anastomosis.
authors.affiliation: Department of Pediatric Surgery, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Lili
authors.initials: L
authors.lastname: Hayari
authors.forename: Dan D
authors.initials: DD
authors.lastname: Hershko
authors.forename: Hadas
authors.initials: H
authors.lastname: Shoshani
authors.forename: Ron
authors.initials: R
authors.lastname: Maor
authors.forename: Daniel
authors.initials: D
authors.lastname: Mordecovich
authors.forename: Gideon
authors.initials: G
authors.lastname: Shoshani
mesh_terms: D000714:Anastomosis, Surgical / Q000009:adverse effects*; D000818:Animals; D004285:Dogs; D004940:Esophageal Stenosis / Q000209:etiology / Q000517:prevention & control*; D005355:Fibrosis; D023421:Models, Animal; D018919:Neovascularization, Physiologic; D009852:Omentum / Q000601:surgery*; D011183:Postoperative Complications; D014945:Wound Healing