title: ADC mapping of the aging frontal lobes in mild cognitive impairment.
abstract: Normal aging, leukoaraiosis (LA) and vascular disease particularly involve the human frontal lobes. We decided to investigate a population of elderly patients referred for neuroimaging because of progressive minor cognitive deficits but no dementia. They underwent conventional Magnetic resonance imaging (MRI) using axial T1 and T2-weighted imaging as well as coronal FLAIR sequences in addition to the axial diffusion-weighted MRI. MRI allowed us to differentiate patients with leukoaraïosis (LA+) from those without it (LA-) and mapping of the apparent diffusion coefficient (ADC) to investigate local tissular water motion. We observed an increase in the ADC in all investigated patients with increasing age (r=0.326, p=0.002). This increase was observed in both patients groups (LA+ and LA-). In addition, the LA+ group had significant higher ADC values than the LA- group after controlling for age (p<0.0001).
authors.affiliation: Neuroradiology SRRI, Geneva University Hospital, HUG, Rue Micheli-du-Crest 24, 1211 Geneva, Switzerland. karl-olof.lovblad@hcuge.ch
authors.forename: K O
authors.initials: KO
authors.lastname: Lövblad
authors.forename: J
authors.initials: J
authors.lastname: Delavelle
authors.forename: S
authors.initials: S
authors.lastname: Wetzel
authors.forename: A D
authors.initials: AD
authors.lastname: Kelekis
authors.forename: F
authors.initials: F
authors.lastname: Assal
authors.forename: M
authors.initials: M
authors.lastname: Palmesino
authors.forename: G
authors.initials: G
authors.lastname: Gold
authors.forename: H
authors.initials: H
authors.lastname: Yilmaz
authors.forename: D
authors.initials: D
authors.lastname: San Millan Ruiz
authors.forename: F
authors.initials: F
authors.lastname: Lazeyras
authors.forename: A
authors.initials: A
authors.lastname: Mehdizade
authors.forename: D A
authors.initials: DA
authors.lastname: Rüfenacht
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000503:physiopathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007962:Leukocytes; D008297:Male; D008875:Middle Aged