title: Inhibition of patulin production by Penicillium expansum cultured with neem (Azadirachta indica) leaf extracts.
abstract: Aqueous extract of the leaves of neem [Azadirachta indica A. JUSS (Meliaceae)] was tested in vitro for antifungal activity against Penicillium expansum. Patulin production was inhibited during cultivation, when concentrations higher than 50 mg/ml of neem leaf extract was added to the culture medium. Analyses of mycotoxin production were performed by TLC and HPLC. Fungal growth and colony characteristics, in the presence of the extract, were investigated and compared with extract-free cultures.
authors.affiliation: Department of Biochemistry, Universidade Estadual de Maringá, Maringá PR Brazil.
authors.forename: Simone Aparecida Galerani
authors.initials: SA
authors.lastname: Mossini
authors.forename: Kesia Pires
authors.initials: KP
authors.lastname: de Oliveira
authors.forename: Carlos
authors.initials: C
authors.lastname: Kemmelmeier
mesh_terms: D031601:Azadirachta; D004305:Dose-Response Relationship, Drug; D010365:Patulin / Q000378:metabolism*; D010407:Penicillium / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves
chemical_list: D010936:Plant Extracts; D010365:Patulin