title: Transient crossed aphasia evidenced by functional brain imagery.
abstract: Crossed aphasia refers to language deficits induced by unilateral right hemisphere injuries in right-handed people who had no previous history of brain damage. One of the intriguing questions concerning crossed aphasia is the atypical language representation in the brain. In this respect, fMRI is a valuable tool for understanding the neural basis of crossed aphasia. Here, we used neuropsychological and fMRI language tasks in a right-handed subject who presented a crossed aphasia due to a right frontal meningioma. fMRI maps from two language tasks showed bilateral patterns of activation. In the light of previous studies reporting much frequent bilateral than exclusive right hemisphere representations, we hypothesise that some crossed aphasia cases could occur in subjects with bilateral language representation.
authors.affiliation: Neuropsychology Unit, Department of Neurology, Geneva University Hospitals, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. Asaid.Khateb@hcuge.ch
authors.forename: Asaid
authors.initials: A
authors.lastname: Khateb
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Martory
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Annoni
authors.forename: François
authors.initials: F
authors.lastname: Lazeyras
authors.forename: Nicolas
authors.initials: N
authors.lastname: de Tribolet
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Pegna
authors.forename: Eugène
authors.initials: E
authors.lastname: Mayer
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Michel
authors.forename: Mohamed L
authors.initials: ML
authors.lastname: Seghier
mesh_terms: D001037:Aphasia / Q000175:diagnosis* / Q000473:pathology*; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000150:complications; D005625:Frontal Lobe / Q000473:pathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007802:Language; D007807:Language Tests / Q000706:statistics & numerical data; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008579:Meningioma / Q000150:complications; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data