title: First case of isolated small bowel transplantation at the university of cologne: rejection-free course under quadruple immunosuppression and endoluminal monitoring with video-capsule.
abstract: Intestinal transplantation is the only curative form of treatment for fulminant short bowel syndrome. Results have been hampered by frequent rejection episodes as well as technical and infectious complications. We report the first case of complete small bowel transplantation performed at our institution. A 37-year-old male patient suffered from massive gut infarction due to a superior mesenteric artery embolus from a thrombus in the descending aorta resulting from hereditary protein S and C deficiency. The primary surgery resulted in a duodenocolostomy requiring total parenteral nutrition. The course was further complicated by multiple central line infections and pre-renal kidney failure induced by dehydration. After 17 months, we performed a cadaveric small bowel transplant using systemic venous drainage. The ileum was anastomosed end-to-end to the recipient ascending colon. The proximal jejunum was used to create a jejunostomy, with an end-to-side duodenojejunostomy. Immunosuppression consisted of a single-administration of antithymocyte globulin (ATG), tacrolimus, mycophenolate mofetil (MMF), and methylprednisolone given enterally from day 1. Biopsies of the upper jejunum showed no signs of rejection. The graft was monitored via capsule video endoscopy after 9 weeks and appeared normal. The patient was discharged on day 35, completely on an enteral diet and gaining weight with a good quality of life. Oral valganciclovir was given for the cytomegalovirus prophylaxis infection (donor-positive, recipient-negative constellation), with no clinical or serologic signs of infection. The early course after small bowel transplantation using a quadruple regimen was clinically successful. The use of video-capsules allows for noninvasive visual monitoring of bowel segments that cannot be reached endoscopically.
authors.affiliation: Visceral- und Gefasschirurgie, Köln, Germany. tobias.beckurts@medizin.uni-koeln.de
authors.forename: K T E
authors.initials: KT
authors.lastname: Beckurts
authors.forename: D
authors.initials: D
authors.lastname: Stippel
authors.forename: K
authors.initials: K
authors.lastname: Schleimer
authors.forename: H
authors.initials: H
authors.lastname: Schäfer
authors.forename: C
authors.initials: C
authors.lastname: Benz
authors.forename: H-P
authors.initials: HP
authors.lastname: Dienes
authors.forename: A H
authors.initials: AH
authors.lastname: Hölscher
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical; D003106:Colon / Q000601:surgery; D004359:Drug Therapy, Combination; D005858:Germany; D006801:Humans; D007082:Ileum / Q000473:pathology / Q000637:transplantation*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D012778:Short Bowel Syndrome / Q000601:surgery*; D014184:Transplantation, Homologous / Q000276:immunology / Q000379:methods; D014741:Video Recording
chemical_list: D007166:Immunosuppressive Agents