The new kid on the block(ade) of the IGF-1 receptor.
The insulin-like growth factors (IGF) system, and particularly the IGF-1 receptor, has recently become the subject of major interest in the arena of cancer research. Its involvement in cancer cell growth and survival makes the system an excellent target as potential adjunct therapy to standard chemotherapy.
LeRoith
Derek
D
Diabetes Branch, NIDDK, Pediatric Oncology Branch, NCI, Bethesda, MD 20892 USA. derek@helix.nih.gov
Helman
Lee
L
D002455:Cell Division / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007334:Insulin-Like Growth Factor I / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008024:Ligands; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D017526:Receptor, IGF Type 1 / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D004791:Enzyme Inhibitors; D008024:Ligands; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1