Medical genetics: a marker for Stevens-Johnson syndrome.
Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.
Chung
Wen-Hung
WH
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Hung
Shuen-Iu
SI
Hong
Hong-Shang
HS
Hsih
Mo-Song
MS
Yang
Li-Cheng
LC
Ho
Hsin-Chun
HC
Wu
Jer-Yuarn
JY
Chen
Yuan-Tsong
YT
D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D004049:Diethylcarbamazine / Q000009:adverse effects; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen; D006801:Humans; D015994:Incidence; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics
D015235:HLA-B Antigens; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D004049:Diethylcarbamazine