[Saccharomyces cerevisiae: an efficient tool and model system for anticancer research].
The major mechanisms of cell function, such as metabolic pathways, DNA repair and cell cycle control have been conserved throughout DNA evolution from yeast to human, despite the former lacks cancer-related features. The S. cerevisiae genome has been entirely sequenced and not only reveals sequence similarity to the human, but a number of proteins also have a conserved function. Owing to its genetic features, yeast has been used as a remarkable model and tool to study important enzymes that are also targets for anticancer drugs, particularly in the field of the pyrimidine salvage pathway. In this review, we describe the recent developments in using yeast for anticancer research, focusing on metabolic pathway analysis, systematic drugs screening with yeast mutants or prospects in gene therapy with yeast enzymes.
Kurtz
Jean-Emmanuel
JE
Département d'hématologie et d'oncologie des Hôpitaux universitaires de Strasbourg, 1, avenue Molière, 67098 Strasbourg. jean-emmanuel.kurtz@chru-strasbourg.fr
Dufour
Patrick
P
Duclos
Brigitte
B
Bergerat
Jean-Pierre
JP
Exinger
Françoise
F
D000970:Antineoplastic Agents / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D010641:Phenotype; D011355:Prodrugs / Q000378:metabolism; D011743:Pyrimidines; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011355:Prodrugs; D011743:Pyrimidines