title: Preparation and characterization of reverse micelle based organogels of piroxicam.
abstract: The solubilization of piroxicam to increase transdermal permeation rate was attempted by incorporating the drug in reverse micelle systems consisting of lecithin/isopropyl myristate/water [RMS-1] and sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/isooctane/water [RMS-2]. The change in polarity of water present in the water pool formed by reverse micelles resulted in a solubilization of piroxicam. These systems were used for the formation of reverse micellar organogels RMO-1 and RMO-2 by means of either varying hydration ratio (Wo) or by addition of a macromolecule, e.g. gelatin, into the system or by taking both the parameters in consideration. These systems were evaluated for physical properties, toxicology, in vitro and in vivo transdermal permeation. Significant (p < 0.01) inhibition of carrageenan induced rat paw oedema was observed for products RMO-1 and RMO-2 and a marketed transdermal product after 3 h.
authors.affiliation: Pharmaceutical Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar, India.
authors.forename: G P
authors.initials: GP
authors.lastname: Agrawal
authors.forename: M
authors.initials: M
authors.lastname: Juneja
authors.forename: S
authors.initials: S
authors.lastname: Agrawal
authors.forename: S K
authors.initials: SK
authors.lastname: Jain
authors.forename: S S
authors.initials: SS
authors.lastname: Pancholi
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D002626:Chemistry, Pharmaceutical; D005782:Gels; D008823:Micelles; D010894:Piroxicam / Q000737:chemistry* / Q000493:pharmacokinetics / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D012869:Skin Absorption; D012997:Solvents; D013501:Surface-Active Agents; D013696:Temperature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D008823:Micelles; D012997:Solvents; D013501:Surface-Active Agents; D010894:Piroxicam