title: Genes in the service of therapeutic index: progress for virus-directed enzyme prodrug therapy.
authors.forename: Edward A
authors.initials: EA
authors.lastname: Sausville
mesh_terms: D001388:Aziridines / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D018736:DNA Adducts; D004926:Escherichia coli / Q000201:enzymology; D005818:Genetic Engineering; D015316:Genetic Therapy; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy* / Q000821:virology; D009601:Nitroreductases / Q000235:genetics / Q000494:pharmacology; D011355:Prodrugs / Q000008:administration & dosage / Q000627:therapeutic use*; D012328:RNA Viruses / Q000235:genetics*
chemical_list: D001388:Aziridines; D018736:DNA Adducts; D011355:Prodrugs; C100099:tretazicar; D009601:Nitroreductases