title: [Effect of 2000 m descent simulated in a hyperbaric chamber on arterial blood oxygen saturation and sleep quality in workers of a gold mine situated at an altitude of 3800-4200 m above sea level].
abstract: Acute mountain sickness can become life threatening to people traveling at high altitude. Simulated descent with a hyperbaric chamber is a widely accepted way to treat this condition. The aim of this study was to analyze the influence of simulated descent to 2000 m on arterial oxygen saturation (SaO2), periodic breathing and sleep quality in a group of workers of a gold mine situated at 3800 m. Sleep studies were performed twice in stationary hyperbaric chamber with a portable system--MESAM IV in 20 workers. During the first study the chamber was not pressurized and on the second night the barometric pressure was set to mimic descent to 2000 m. During second study, a significant decrease in ODI (Oxygen Desaturation Index), from 9.7 +/- 6/h to 1.8 +/- 3.4/h (p < 0.0001), was noticed; mean SaO2 increased from 84.3 +/- 3.2% do 92.7 +/- 2.8% (p < 0.0001), significant changes in percentage of study time in individual SaO2 ranges were also noticed. The number (12.7 +/- 8.4 vs. 7.5 +/- 5; p < 0.05) and index of changes in body position were decreased (2.0 +/- 1.5 vs. 1.2 +/- 0.9/h; p < 0.05) as well.
  
  
  CONCLUSIONS
  Simulated descent to 2000 m causes a decrease in number of desaturations, improvement in mean SaO2 during sleep, decrease in heart rate and these data suggest a decrease in periodic breathing during sleep. A decrease in number and index of body position changes suggests improved sleep quality.
authors.affiliation: Katedra i Klinika Chorób Wewnetrznych Pneumonologii i Alergologii Akademia Medyczna w Warszawie. przybe@mwaw.edu.pl
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Przybyłowski
authors.forename: Aibek
authors.initials: A
authors.lastname: Ashirbaev
authors.forename: Johannes
authors.initials: J
authors.lastname: Le Roux
authors.forename: Jan
authors.initials: J
authors.lastname: Zieliński
mesh_terms: D000064:Acclimatization / Q000502:physiology; D000328:Adult; D000531:Altitude; D006801:Humans; D006931:Hyperbaric Oxygenation; D007707:Kyrgyzstan; D008297:Male; D008875:Middle Aged; D008906:Mining; D010100:Oxygen / Q000097:blood*; D017286:Polysomnography / Q000379:methods; D012016:Reference Values; D012119:Respiration; D012890:Sleep / Q000502:physiology; D012894:Sleep Stages / Q000502:physiology; D012895:Sleep, REM / Q000502:physiology; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D010100:Oxygen