Fatal overdosage with cisplatin.
This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart and peripheral blood concentrations of platinum were 1515 and 1253 micro g/L, respectively. Concentrations in urine and bile were 1038 and 501 micro g/L, respectively. Renal dialysis was started immediately after the end of cisplatin perfusion, when the mistake was noticed, but the patient deceased at day 16, presenting renal and hepatic insufficiency, ototoxicity, and pancytopenia.
Charlier
C
C
Laboratory of Clinical Toxicology, University Hospital, Liege, Belgium. C.CHARLIER@chu.ulg.ac.be
Kintz
P
P
Dubois
N
N
Plomteux
G
G
D000059:Accidents; D000970:Antineoplastic Agents / Q000378:metabolism / Q000506:poisoning*; D002423:Cause of Death; D002945:Cisplatin / Q000378:metabolism / Q000506:poisoning*; D062787:Drug Overdose; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D002945:Cisplatin