title: [Vitamin B12 in the adult: of metabolism and deficiencies].
abstract: OBJECTIVE
  Update on cobalamin deficiencies in adults.
  
  
  BACKGROUND
  More precise definitions establish real cobalamin deficiency and determine epidemiological features. Current data on cobalamin metabolism suggest the concept of non-dissociation of vitamin B12 from its carrier proteins (NDB12), a generalization of the food-cobalamin malabsorption concept. The new features of cobalamin deficiency include neurological, gynecological and vascular manifestations. Current treatment modalities include nasal and oral administration of cobalamin.
  
  
  CONCLUSIONS
  Validate the concept of NDB12 and the usefulness of oral cobalamin therapy, establish the relevance of the new clinical manifestations.
authors.affiliation: Service de Médecine Interne, Diabète et Maladies Métaboliques de la Clinique Médicale B des Hôpitaux Universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France.
authors.forename: N Henoun
authors.initials: NH
authors.lastname: Loukili
authors.forename: E
authors.initials: E
authors.lastname: Andrès
mesh_terms: D000328:Adult; D005743:Gastrectomy; D006801:Humans; D008286:Malabsorption Syndromes; D014155:Transcobalamins; D014805:Vitamin B 12 / Q000378:metabolism* / Q000502:physiology; D014806:Vitamin B 12 Deficiency / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology
chemical_list: D014155:Transcobalamins; D014805:Vitamin B 12