Naphthalanotherapy reduces angiogenetic factor in psoriatic lesion.
Immunohistochemical analysis (cell immunophenotyping before and after 3 weeks of treatment with naphthalan oil) was performed on biopsy specimens from 10 patients with psoriasis vulgaris. To determine the angiogenetic factor in psoriatic lesions, immunohistochemical staining on 3-microm paraffin block sections was performed by using monoclonal anti-factor VIII antibody. There was a significant difference in the mean number of new blood vessels before and after the therapy (15.1 vs. 6.7). It seems that naphthalan therapy reduces number of new blood vessels and has effect on neovascularization in patients with psoriasis.
Vrzogić
Pero
P
Naftalan Special Hospital for Medical Rehabilitation, 10310 Ivanić Grad, Croatia. jasna.lipozencic@zg.tel.hr
Jakić-Razumović
Jasminka
J
Lipozencić
Jasna
J
D000287:Administration, Topical; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage*; D001494:Baths; D005260:Female; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D011565:Psoriasis / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology
D020533:Angiogenesis Inhibitors; D009281:Naphthalenes; C043836:naphthalan