Deletion (11)(q13) as the sole anomaly in myeloid malignancies: four new cases and a short review.
Chromosomal abnormalities are of significance in the study of hematologic malignancies. We describe one case of myelodysplastic syndrome (MDS) diagnosed 22 years ago as polycythemia vera (PV) as well as a case of unclassified myeloproliferative disease (MPD) with a poor clinical course. Both patients presented del(11)(q13) as the sole clonal abnormality. This abnormality was also found in two additional cases of MDS. Summarizing the literature, only ten other cases of myeloid malignancies with deletion of 11q involving band q13 as the sole anomaly have been reported. All but one of these cases presented interstitial deletions.
Panani
Anna D
AD
Second Department of Internal Medicine Propaedeutic, Research Unit of Athens University, Evangelismos Hospital, 10676, Athens, Greece. apanani@med.uoa.gr
Pappa
Vasiliki
V
Papageorgiou
Sotirios
S
Stamatelli
Francs
F
Raptis
Sotirios A
SA
D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000628:therapy; D009196:Myeloproliferative Disorders / Q000235:genetics*; D011087:Polycythemia Vera / Q000235:genetics / Q000628:therapy; D016019:Survival Analysis