[Expression of c-jun and c-fos oncogene in medulloblastoma and its clinical significance].
OBJECTIVE
To study the potential relationship between the expressions of c-jun and c-fos oncogenes and the prognosis of medulloblastoma.


METHODS
The specimens from 70 cases of medulloblastoma of the posterior fossa and 10 cases of normal cerebellar tissues were collected to determine c-jun and c-fos expressions by immunohistochemical staining in formalin fixed paraffin-embedded sections.


RESULTS
(1) It showed that c-fos and c-jun protein expression was negative in 10 normal cerebellar tissue, while positive c-fos, c-jun immunoreactivity was found in 70 medulloblastoma specimens. The positive rate of c-jun and c-fos was 80% and 77%, respectively. There was high expression of c-jun and c-fos protein in medulloblastoma tissues. (2) There were positive correlations and strong co-operativity between c-jun and c-fos expression (r = 0.493, P < 0.01). (3) Correlative analysis indicated that expression of c-jun, c-fos were significantly correlated with survival time (c-jun: r = -0.447, P < 0.01; c-fos: r = -0.590, P < 0.01). The higher the expression level of c-jun and c-fos protein was, the worse the prognosis was in medulloblastoma patients.


CONCLUSIONS
High expression of c-jun and c-fos protein could be noted in medulloblastoma tissues. The two transcription factors show positive correlation and strong co-existence between c-jun and c-fos expressions. The expression levels of c-jun as well as c-fos are negatively correlated with the mortality rate and life expectancy of patients with medulloblastoma. In addition, the co-expression of c-jun and c-fos could serve as an indicator for judging the prognosis of medulloblastoma.
Li
Yuan-yang
YY
Department of Neurosurgery, Affiliated Hospital of Jining Medical College, Shandong 272029, China.
Mao
Bo-yong
BY
Dong
Xiao-hong
XH
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008527:Medulloblastoma / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D016755:Proto-Oncogene Proteins c-jun / Q000032:analysis*; D016019:Survival Analysis; D015996:Survival Rate
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun