Regulation of arachidonic acid availability for eicosanoid production.
Mammalian cells have developed specific pathways for the incorporation, remodeling, and release of arachidonic acid. Acyltransferase and transacylase pathways function to regulate the levels of esterified arachidonic acid in specific phospholipid pools. There are several distinct, differentially regulated phospholipases A2 in cells that mediate agonist-induced release of arachidonic acid. These pathways are important in controlling cellular levels of free arachidonic acid. Both arachidonic acid and its oxygenated metabolites are potent bioactive mediators that regulate a myriad of physiological and pathophysiological processes.
Leslie
Christina C
CC
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA. lesliec@njc.org
D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D015777:Eicosanoids / Q000096:biosynthesis*; D054501:Group II Phospholipases A2; D054522:Group VI Phospholipases A2; D051379:Mice; D018345:Mice, Knockout; D010741:Phospholipases A / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D015777:Eicosanoids; D010743:Phospholipids; D016718:Arachidonic Acid; D000217:Acyltransferases; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D054522:Group VI Phospholipases A2; C516476:Pla2g6 protein, mouse