Identification and differential vulnerability of a neural network in sleep deprivation.
The study aimed to identify task-related brain activation networks whose change in expression exhibits subject differences as a function of differential susceptibility to sleep deprivation. Brain activity during a non-verbal recognition memory task was investigated in an event-related functional MRI paradigm both prior to and after 48 h of sleep deprivation. Nineteen healthy subjects participated. Regional covariance analysis was applied to data. An activation network pattern was identified whose expression decreased from pre- to post-sleep deprivation in 15 out 19 subjects (P < 0.05). Differential decrease in expression correlated with worsening performance in recognition accuracy (P < 0.05). Sites of de-activation were found in the posterior cerebellum, right fusiform gyrus and precuneus, and left lingual and inferior temporal gyri; increased activation was found in the bilateral insula, claustrum and right putamen. A network whose expression decreased after sleep deprivation and correlated with memory performance was identified. We conclude that this activation network plays a role in cognitive function during sleep deprivation.
Bell-McGinty
Sandra
S
Cognitive Neuroscience Division of the Taub Institute for Research in Alzheimer's Disease and the Aging Brain, 630 West 168th Street, PH-18, New York, USA.
Habeck
Christian
C
Hilton
H John
HJ
Rakitin
Brian
B
Scarmeas
Nikolaos
N
Zarahn
Eric
E
Flynn
Joseph
J
DeLaPaz
Robert
R
Basner
Robert
R
Stern
Yaakov
Y
D000222:Adaptation, Physiological; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003071:Cognition; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D010363:Pattern Recognition, Automated; D011597:Psychomotor Performance; D012892:Sleep Deprivation / Q000503:physiopathology*; D013647:Task Performance and Analysis