title: Major tumor regression after paclitaxel and carboplatin polychemotherapy in a patient with advanced penile cancer.
abstract: Penile cancer is rare in Western countries. High-risk patients are considered for prophylactic inguinal lymphadenectomy. For advanced disease, a triplet drug regimen consisting of bleomycin, methotrexate, and cisplatin is the most active combination tested so far. A 62-year-old man with penile cancer underwent partial penile amputation but presented 10 months later with inguinal nodal metastasis. He received three cycles of paclitaxel/carboplatin with marked clinical and radiologic (computed tomography and positron emission tomography) tumor regression. Later, complete resection of the inguinal nodal metastasis was performed. The paclitaxel/carboplatin combination has potential activity in penile cancer. Positron emission tomography may be used for screening of nodal metastases.
authors.affiliation: Department of Medical Oncology, Kantonsspital, St. Gallen, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Joerger
authors.forename: T
authors.initials: T
authors.lastname: Warzinek
authors.forename: B
authors.initials: B
authors.lastname: Klaeser
authors.forename: J T
authors.initials: JT
authors.lastname: Kluckert
authors.forename: H-P
authors.initials: HP
authors.lastname: Schmid
authors.forename: S
authors.initials: S
authors.lastname: Gillessen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D010412:Penile Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D010413:Penis / Q000601:surgery; D012074:Remission Induction / Q000379:methods; D016019:Survival Analysis; D014055:Tomography, Emission-Computed
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D019788:Fluorodeoxyglucose F18; D016190:Carboplatin; D017239:Paclitaxel