title: Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.
abstract: Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.
authors.affiliation: Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. jmp21@psu.edu
authors.forename: Fred S
authors.initials: FS
authors.lastname: Harman
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Nicol
authors.forename: Holly E
authors.initials: HE
authors.lastname: Marin
authors.forename: Jerrold M
authors.initials: JM
authors.lastname: Ward
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Gonzalez
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Peters
mesh_terms: D000818:Animals; D001397:Azoxymethane / Q000633:toxicity; D003110:Colonic Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D003111:Colonic Polyps / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D010641:Phenotype; D018160:Receptors, Cytoplasmic and Nuclear / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D001397:Azoxymethane