title: Postpartum amenorrhoea-galactorrhoea associated with hyperprolactinaemia and pituitary enlargement in primary hypothyroidism.
abstract: We report a 36-year-old woman with primary hypothyroidism revealed by postpartum amenorrhoea-galactorrhoea associated with hyperprolactinaemia and suprasellar pituitary enlargement on magnetic resonance imaging (MRI). On thyroid hormone replacement therapy all clinical, biochemical, radiological and endocrine abnormalities disappeared. Hyperplasia of pituitary thyrotrophs and/or lactotrophs seems to be responsible for the pituitary enlargement seen on MRI.
authors.affiliation: Department of Internal Medicine, MCRZ-Clara Hospital, Rotterdam, The Netherlands. jmkroese@noknok.nl
authors.forename: J M
authors.initials: JM
authors.lastname: Kroese
authors.forename: A F
authors.initials: AF
authors.lastname: Grootendorst
authors.forename: L J D M
authors.initials: LJ
authors.lastname: Schelfhout
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D005687:Galactorrhea / Q000209:etiology*; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications*; D007037:Hypothyroidism / Q000150:complications; D008279:Magnetic Resonance Imaging; D010902:Pituitary Gland / Q000473:pathology*; D049590:Postpartum Period; D011247:Pregnancy; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine