Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases.
We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described.
Saito
Fumiyo
F
Frontier Research Center for Genome and Drug Discovery, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
Takeuchi
Ryo
R
Kamino
Tomoyuki
T
Kuramochi
Kouji
K
Sugawara
Fumio
F
Sakaguchi
Kengo
K
Kobayashi
Susumu
S
D003517:Cyclopentanes / Q000138:chemical synthesis / Q000494:pharmacology*; D004253:DNA Nucleotidylexotransferase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005561:Formates / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D007189:Indans / Q000138:chemical synthesis / Q000494:pharmacology*; D007982:Levulinic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D019384:Nucleic Acid Synthesis Inhibitors; D013329:Structure-Activity Relationship
D003517:Cyclopentanes; D004791:Enzyme Inhibitors; D005561:Formates; D007189:Indans; D007982:Levulinic Acids; D019384:Nucleic Acid Synthesis Inhibitors; C492887:manzamenone A; C492889:plakevulin A; C492888:untenone A; D004253:DNA Nucleotidylexotransferase