Synthesis and morphine enhancement activity of N-[5-(2-phenoxyphenyl)-1, 3, 4-oxadiazole-2-yl]-N'-phenylurea derivatives.
The synthesis of N-[5-(2-phenoxyphenyl)-1, 3, 4-oxadiazole-2-yl]-N'-phenylurea derivatives is reported. The structures of these compounds are supported by their IR, (1)H-NMR and mass spectra. Conformational analysis and superimposition of energy minima conformers of these compounds on L-365, 260, a known 3-ureido-1, 4-benzodiazepine CCK-B antagonist, showed that the aromatic rings fell in the same contour. Morphine analgesia enhancement evaluation of the synthesized compounds in comparison with a control group showed that compounds 8a, 8c, 8h-8j, 8l, 8o have significant effects.
Rad
Ali Almasi
AA
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty ofPharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Sheikhha
Majid
M
Hosseini
Rohollah
R
Tabatabaic
Sayyed Abbas
SA
Shafiee
Abbas
A
D000698:Analgesia; D000818:Animals; D004357:Drug Synergism; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D009020:Morphine; D010671:Phenylurea Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; D009020:Morphine