Got MLL? Definitive hematopoiesis requires MLL gene expression.
A manuscript by Ernst and colleagues in the March 2004 issue of Developmental Cell demonstrates that following hematopoietic stem cell appearance in the AGM, expression of the MLL transcription factor is required for their subsequent differentiation.
Dorshkind
Kenneth
K
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 USA.
Witte
Owen
O
D002454:Cell Differentiation / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox; D006410:Hematopoiesis / Q000235:genetics* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008954:Models, Biological; D051788:Myeloid-Lymphoid Leukemia Protein; D011519:Proto-Oncogenes; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein