Antinociceptive properties of chloromaleinimides and their sulphonyl derivatives.
This report describes the synthesis of new cyclic imides obtained from the reaction between aniline and dichloromaleic anhydride with further chlorosulphonation as well as the reaction between different amines and 4-methoxyphenol for the synthesis of imidobenzenesulphonyl derivatives. These compounds were tested as antinociceptive agents using the writhing test on mice. Some compounds, when intraperitoneally injected, proved to be potent and dose-related antinociceptives, being several times more active than many known reference drugs.
Walter
Maria Elena
ME
Laboratório de Síntese e Estrutura Atividade, Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis/SC, Brazil.
Mora
Cristiano
C
Mundstock
Karoline
K
de Souza
Mércia M
MM
de Oliveira Pinheiro
Andréia
A
Yunes
Rosendo Augusto
RA
Nunes
Ricardo J
RJ
D000698:Analgesia; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000700:Analgesics; D013449:Sulfonamides