title: Completion by the 10th generation of the bidirectional selective breeding of GHB-sensitive and GHB-resistant rats.
abstract: The present paper describes the completion of the bidirectional selective breeding of gamma-hydroxybutyric acid (GHB)-sensitive (GHB-S) and GHB-resistant (GHB-R) rats, which display opposite sensitivity to the sedative/hypnotic effect of 1 g/kg GHB. Completion of the selective breeding process was achieved by the F10, when 100% of rats of each line fulfilled the selection criterion. GHB-S and GHB-R rats may constitute a valuable tool for investigations on GHB physiology and pharmacology.
authors.affiliation: Bernard B. Brodie Department of Neuroscience, University of Cagliari, Viale Diaz 182, I-09126 Cagliari, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Lobina
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Colombo
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Gessa
authors.forename: Mauro A M
authors.initials: MA
authors.lastname: Carai
mesh_terms: D000818:Animals; D001947:Breeding / Q000379:methods*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains / Q000235:genetics*; D012890:Sleep / Q000187:drug effects; D013045:Species Specificity
chemical_list: D006885:Hydroxybutyrates; C111420:4-hydroxybutyric acid