Tuberculosis-like lesions arising from the use of Freund's complete adjuvant in an owl monkey (Aotus sp.).
An apparently normal, non-tuberculin-reacting, splenectomized owl monkey presented tuberculosis-like lesions of the lung at necropsy. Histological and bacteriological examination failed to demonstrate the presence of acid-fast organisms. Retrospective inquiry showed the animal had been inoculated using complete Freund's adjuvant during a malaria vaccine trial. Lesions observed were compatible with lipid embolism of the adjuvant in the lungs.
Málaga
Carlos A
CA
University of Puerto Rico, San Juan, Puerto Rico.
Weller
Richard E
RE
Roger Broderson
J
J
Gozalo
Alfonso S
AS
D000818:Animals; D016645:Aotidae; D004617:Embolism / Q000209:etiology / Q000473:pathology; D005620:Freund's Adjuvant / Q000009:adverse effects*; D006403:Hematologic Tests; D006652:Histological Techniques; D008168:Lung / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008992:Monkey Diseases / Q000209:etiology / Q000473:pathology*; D009336:Necrosis
D005620:Freund's Adjuvant