title: Tie-1 tyrosine kinase expression in human thyroid neoplasms.
abstract: OBJECTIVE
  To investigate tie-1 expression in human thyroid neoplasms. Recent studies have demonstrated that receptor-type tyrosine kinases (RTKs) contribute to carcinoma progression. Tie-1 is one of the RTKs and plays a role in angiogenesis, although its pathophysiological significance in human carcinoma is still to be elucidated.
  
  
  RESULTS
  Immunohistochemical expression of tie-1 was studied in various thyroid neoplasms. Tie-1 immunoreactivity was only occasionally observed in normal follicular cells. In papillary carcinoma, tie-1 was classified as positive in carcinoma cells in 55.7% of the cases and was more frequently expressed in those of smaller size with an absence of a poorly differentiated lesion. In contrast, tie-1 was positive in only 8.3% of anaplastic carcinoma and no cases of follicular carcinoma or adenoma were positive.
  
  
  CONCLUSIONS
  These results suggest that tie-1 has a role in thyroid tumorigenesis, especially in the early phase of papillary carcinoma, but it is not important in the progression of anaplastic carcinoma or follicular tumour.
authors.affiliation: Kuma Hospital, Kobe, Japan. ito01@kuma-h.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Uruno
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: Y
authors.initials: Y
authors.lastname: Takamura
authors.forename: A
authors.initials: A
authors.lastname: Miya
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Yokozawa
authors.forename: F
authors.initials: F
authors.lastname: Matsuzuka
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: A
authors.initials: A
authors.lastname: Miyauchi
mesh_terms: D002277:Carcinoma / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D042810:Receptor, TIE-1 / Q000235:genetics* / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism* / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D042810:Receptor, TIE-1