NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1.
We have identified a new domain in a broad range of bacterial, as well as single archaeal and plant proteins. Its presence in the virulence-related pXO1 plasmid of Bacillus anthracis as well as in several other pathogens makes it a possible drug target. We term the new domain nuclease-related domain (NERD) because of its distant similarity to endonucleases.
Grynberg
Marcin
M
Program in Bioinformatics and Systems Biology, The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Godzik
Adam
A
D000595:Amino Acid Sequence; D001408:Bacillus anthracis / Q000737:chemistry* / Q000235:genetics; D017124:Conserved Sequence / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D014774:Virulence / Q000235:genetics
D004269:DNA, Bacterial; D014764:Viral Proteins