Crohn's disease post-cardiac transplantation presenting with severe growth failure and delayed onset of puberty.
We report a 15 yr-old girl who 10 yr post-cardiac transplantation presented with severe growth failure and delayed onset of puberty. She was found to have pan-enteric Crohn's disease and has done remarkably well on principally nutritional therapy with a significant growth spurt and the onset of menarche. The development of bowel disease whilst on immunosuppression is rare and the literature is reviewed.
Harms
Bettina
B
Paediatric Medical Unit, Southampton General Hospital, Southampton, Hampshire, UK.
Bremner
A Ronald
AR
Mulligan
Jean
J
Fairhurst
Joanna
J
Griffiths
D Mervyn
DM
Salmon
Tony
T
Beattie
R Mark
RM
D000293:Adolescent; D003424:Crohn Disease / Q000150:complications / Q000503:physiopathology*; D004750:Enteral Nutrition / Q000379:methods; D005260:Female; D006130:Growth Disorders / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents; D011183:Postoperative Complications; D011628:Puberty, Delayed / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
D007166:Immunosuppressive Agents