title: Biscoumarin: new class of urease inhibitors; economical synthesis and activity.
abstract: A variety of biscoumarins (1-21) with variable substituents at C-11 were synthesized with an improved method and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 15.06-91.35 microM. The size and electron donating or withdrawing effects of substituents influenced the activity, which lead to the urease inhibitors.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Sajid
authors.initials: S
authors.lastname: Iqbal
authors.forename: Muhammad Arif
authors.initials: MA
authors.lastname: Lodhi
authors.forename: Ghulam Murtaza
authors.initials: GM
authors.lastname: Maharvi
authors.forename: Zia
authors.initials: Z
authors.lastname: Ullah
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Atta-Ur
authors.initials: AU
authors.lastname: Rahman
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis* / Q000191:economics / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000191:economics / Q000494:pharmacology; D014510:Urease / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D003374:Coumarins; D004791:Enzyme Inhibitors; C030123:coumarin; D014510:Urease