title: Degradation of ethyl docosahexaenoate by gamma-ray irradiation and suppression of this degradation by antioxidants.
abstract: Ethyl 4,7,10,13,16,19-docosahexaenoate (DHA-Et) dissolved in an ethanol solution or embedded in liposomes was degraded by irradiating with gamma rays in a dose-dependent manner. The degradation rate of DHA-Et embedded in liposomes was higher than that of DHA-Et dissolved in ethanol. Antioxidants suppressed the degradation of DHA-Et embedded in liposomes, the order of activity of the antioxidants being luteolin>fisetin>kaempferol>quercetin>rutin. These results suggest that the hydrophobicity (logP) of an antioxidant is one of determinants for antioxidative activity, but that a vicinal diol structure in the B ring is not favorable for the antioxidative activity.
authors.affiliation: Faculty of Agriculture, Okayama University, Tsushima-Naka, Japan.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Murata
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Osaki
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Shimoishi
authors.forename: Naomichi
authors.initials: N
authors.lastname: Baba
authors.forename: Mikiro
authors.initials: M
authors.lastname: Tada
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000737:chemistry / Q000378:metabolism / Q000528:radiation effects*; D000431:Ethanol / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D005519:Food Preservation / Q000379:methods; D005720:Gamma Rays; D008081:Liposomes / Q000737:chemistry
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D008081:Liposomes; D004281:Docosahexaenoic Acids; D000431:Ethanol; C067518:4,7,10,13,16,19-docosahexaenoic acid ethyl ester