Outcome determinants of fusariosis in a tertiary care cancer center: the impact of neutrophil recovery.
Factors associated with failure of antifungal therapy were examined in 42 cancer patients with fusariosis (1987-1997). Thirty-six patients (86%) had leukemia and 39 (93%) were neutropenic. Disseminated infection was the most common presentation. The majority (83%) received amphotericin B-based therapy. Thirty patients (71%) failed therapy. No patient with persistent neutropenia responded.
Kontoyiannis
D P
DP
Department of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. dkontoyi@mdanderson.org
Bodey
G P
GP
Hanna
H
H
Hachem
R
R
Boktour
M
M
Girgaway
E
E
Mardani
M
M
Raad
I I
II
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005670:Fusarium; D019337:Hematologic Neoplasms / Q000150:complications* / Q000382:microbiology; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D009503:Neutropenia / Q000150:complications / Q000382:microbiology; D009504:Neutrophils / Q000166:cytology / Q000502:physiology*; D016896:Treatment Outcome