title: Mammographic change in hysterectomized women on 0.625 mg/day of conjugated equine estrogen.
abstract: OBJECTIVE
  To compare the mammographic change before and after conjugated equine estrogen (CEE) 0.625 mg/day in hysterectomized women.
  
  
  METHODS
  A retrospective descriptive study.
  
  
  METHODS
  Menopause clinic, Maharaj Nakorn Chiang Mai Hospital.
  
  
  METHODS
  Dedicated mammograms and demographic data of 66 women who had been hysterectomized were reviewed. Post surgical menopausal women were recruited for the study. CEE 0.625 mg/day was given just after the operation. The baseline mammography was done before the initiation of HRT and they were compared with the follow-up mammography performed 12-18 months after therapy. The degree of increase in mammographic density was classified as follows: minimal changes (10-25% increased density), moderated change (26-50% increased density), and marked change (> 50% increased density).
  
  
  RESULTS
  The mean age +/- SD was 47 +/- 4.3 years old. The mean duration +/- SD of hormone used was 13.5 +/- 2.4 months. The most common indication for operation was myoma uteri (43.9%). On the baseline mammogram, 5 cases had cystic change and one case had a small circumscribed solid mass suspected to be fibroadenoma. On the follow-up mammograms, there were 2 cases (3.0%) detected to have significantly increased breast density. One was moderately increased and the other was markedly increased, but cystic changes and one fibroadenoma were not changed.
  
  
  CONCLUSIONS
  CEE has little effect on increased mammographic density.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50002, Thailand.
authors.forename: Ataporn
authors.initials: A
authors.lastname: Panpanit
authors.forename: Malai
authors.initials: M
authors.lastname: Muttarak
authors.forename: Saipin
authors.initials: S
authors.lastname: Pongsatha
authors.forename: Somsak
authors.initials: S
authors.lastname: Chaovisitsaree
authors.forename: Wirawit
authors.initials: W
authors.lastname: Piyamongkol
authors.forename: Sompong
authors.initials: S
authors.lastname: Truengthawatchai
authors.forename: Nuntana
authors.initials: N
authors.lastname: Morakot
authors.forename: Narisa
authors.initials: N
authors.lastname: Sribanditmongkol
authors.forename: Supranee
authors.initials: S
authors.lastname: Noi-um
authors.forename: Kunnika
authors.initials: K
authors.lastname: Churith
authors.forename: Malinee
authors.initials: M
authors.lastname: Chuntaranikul
mesh_terms: D000328:Adult; D001940:Breast / Q000473:pathology*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D012494:Sampling Studies; D012680:Sensitivity and Specificity
chemical_list: D004966:Estrogens, Conjugated (USP)