title: Modified Mohs micrographic surgery in the therapy of dermatofibrosarcoma protuberans: analysis of 22 patients.
abstract: BACKGROUND
  Dermatofibrosarcoma protuberans (DFSP) is a very rare, low-grade malignant tumor. Local recurrence is frequent after incomplete resection either because of false diagnosis or inadequate standard surgical excision. This study evaluated the clinical outcome of micrographic surgery with paraffin sectioning in the therapy of DFSP.
  
  
  METHODS
  Medical charts of 22 patients with histologically confirmed DFSP treated at our institution between 1987 and 2002 were reviewed.
  
  
  RESULTS
  For 13 patients with primary and 9 with recurrent disease, tumor-free excision margins could be achieved, and all patients remained free of local recurrence during a mean follow-up of 54 months.
  
  
  CONCLUSIONS
  The results of our study and a review of the literature confirm the successful and recurrence-free treatment of DFSP with micrographic surgery as the treatment of choice for this locally invasive tumor. Particularly in recurrent lesions, we recommend the use of paraffin sectioning and three-dimensional histological evaluation as an accurate additional tool for treatment optimization.
authors.affiliation: Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Wacker
authors.forename: Benjamin
authors.initials: B
authors.lastname: Khan-Durani
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hartschuh
mesh_terms: D000328:Adult; D000368:Aged; D018223:Dermatofibrosarcoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery / Q000379:methods*; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome