Hemodynamics, electrolytes, and organ histology of larger-volume liposuction in a porcine model.
Liposuction is a procedure that allows the surgical removal of excess adipose tissue in healthy individuals. Lipoplasty is commonly performed with few clinical side effects. However, with increased lipoaspirate volumes, complications have been reported. In addition, the abnormal appearance of fat cells in other tissues subsequent to lipoplasty has been reported in a small number of cases. The authors examined whether larger-volume lipoplasty, in the porcine model, resulted in disturbances in cardiac or pulmonary output levels, electrolytes, and liver chemistry analyses or alterations in organ histology. Nine adult porcine specimens were subjected to either lipoplasty (n = 6) with the superwet technique or no lipoplasty (n = 3). Using a Swan-Ganz catheter, cardiac output and pulmonary artery pressure measurements were obtained from initial placement before lipoplasty until 48 hours postoperatively. Blood analyte measurements were obtained. Upon euthanization, liver, kidney, and lung specimens were collected and tissue sections were prepared. No significant differences or trends were observed in cardiac parameters or blood analytes between control and experimental groups. Significant elevations in serum aspartate aminotransferase and alanine aminotransferase enzyme levels (p < 0.03) were observed in animals postoperatively (10 to 48 hours) subjected to lipoplasty compared with controls. Upon gross examination, the lung tissues of animals subjected to lipoplasty unexpectedly demonstrated patchy petechial hemorrhages on the pleural surface. Tissue sections revealed marked hemorrhagic congestion and evidence of pulmonary edema. Fat emboli were also identified within the pulmonary and renal systems.
Kenkel
Jeffrey M
JM
Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, 75390-9132, USA. jeffrey.kinkel@utsouthwestern.edu
Brown
Spencer A
SA
Love
Edward J
EJ
Waddle
Jean P
JP
Krueger
Jo Ellen
JE
Noble
Debby
D
Robinson
Jack B
JB
Rohrich
Rod J
RJ
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002302:Cardiac Output; D002407:Catheterization, Swan-Ganz; D004620:Embolism, Fat / Q000209:etiology / Q000473:pathology; D006439:Hemodynamics; D007668:Kidney / Q000473:pathology; D015187:Lipectomy / Q000009:adverse effects; D008168:Lung / Q000473:pathology; D023421:Models, Animal; D011654:Pulmonary Edema / Q000473:pathology; D013552:Swine
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase