title: Cys-Gly-Cys tripeptide complexes of nickel: binuclear analogues for the catalytic site in acetyl coenzyme a synthase.
abstract: The tripeptide, Ac-CysGlyCys-CONH2, is utilized as a ligand to bind Ni in a fashion identical to that found at the active site of acetyl coenzyme A synthase. The Ni-peptide construct is a suitable metalloligand for the preparation of larger structures formed via bridging Cys side chains. The complexes Ni(CysGlyCys)Ni(dppe) and Ni(CysGlyCys)Ni(depe) serve as close structural representations for the binuclear subcluster, exhibiting electrochemical properties that demonstrate facile access to the reduced mixed valent Ni(II)Ni(I) state, which binds CO.
authors.affiliation: Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, USA.
authors.forename: Rangan
authors.initials: R
authors.lastname: Krishnan
authors.forename: Charles G
authors.initials: CG
authors.lastname: Riordan
mesh_terms: D000106:Acetate-CoA Ligase / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D003545:Cysteine / Q000737:chemistry* / Q000378:metabolism; D004563:Electrochemistry; D005998:Glycine / Q000737:chemistry* / Q000378:metabolism; D008667:Metalloproteins / Q000737:chemistry* / Q000378:metabolism; D009532:Nickel / Q000737:chemistry* / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008667:Metalloproteins; D009842:Oligopeptides; D009532:Nickel; D000106:Acetate-CoA Ligase; D003545:Cysteine; D005998:Glycine