An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties.
We describe an efficient total synthesis of triciribine, a tricyclic nucleoside with antineoplastic and antiviral properties, starting from 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine.
Porcari
Anthony R
AR
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA. anthony.porcari@pfizer.com
Townsend
Leroy B
LB
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D006801:Humans; D012263:Ribonucleosides / Q000138:chemical synthesis*; D014127:Toyocamycin / Q000737:chemistry; D014777:Virus Diseases / Q000188:drug therapy*; D014780:Viruses / Q000187:drug effects*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D012263:Ribonucleosides; C023764:triciribine; D014127:Toyocamycin