title: Synthesis and evaluation of lasonolide A analogues.
abstract: Homolasonolide A and 10-desmethyllasonolide A are biologically less active than lasonolide A. The ethyl ester analogue of lasonolide A exhibited higher activity than the parent compound in some biological test.
authors.affiliation: School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-747, South Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Joo
authors.forename: Hyo Shin
authors.initials: HS
authors.lastname: Kwak
authors.forename: Jin Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Ho Young
authors.initials: HY
authors.lastname: Song
authors.forename: Eun
authors.initials: E
authors.lastname: Lee
mesh_terms: D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: C492884:10-desmethyllasonolide A; D018942:Macrolides; C492883:homolasonolide A; C450700:lasonolide A