Pathways of post-transcriptional gene regulation in mammalian germ cell development.
Male germ cell development is orchestrated by complex and disparate patterns of gene expression operating in different cell types. The mechanisms of gene expression underlying these have been dissected in the mouse because of its readily available genetics. These analyses have shown that as well as the traditional transcriptional mechanisms, post-transcriptional regulatory pathways of gene expression are essential for mouse spermatogenesis. Proteins essential for germ cell development have been identified which operate at different points throughout the life cycle of RNA from pre-mRNA splicing to translation and RNA decay in the cytoplasm. Recent data suggests that these post-transcriptional pathways respond to environmental cues via signalling pathways.
Elliott
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Institute of Human Genetics, Centre for Life Central Parkway, University of Newcastle upon Tyne, Newcastle, England. David.Elliott@ncl.ac.uk
D000818:Animals; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice; D014176:Protein Biosynthesis; D026721:RNA 3' End Processing; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D020871:RNA Stability; D015398:Signal Transduction; D013094:Spermatozoa / Q000254:growth & development / Q000378:metabolism*