title: Phosphoinositide 3-kinase: the protein kinase that time forgot.
abstract: Class I phosphoinositide 3-kinases were originally characterized as lipid kinases, although more than 10 years ago they were also found to phosphorylate protein serine residues. However, while there is a vast amount of data on the function of this lipid kinase activity, relatively little is known about the function of the protein kinase activity. We discuss the evidence that suggests that the protein kinase activity of phosphoinositide 3-kinases mediates important signalling functions in cells.
authors.affiliation: Ludwig Institute for Cancer Research, 91 Riding House St, London W1W 7BS, U.K. lafouk@ludwig.ucl.ac.uk
authors.forename: L C
authors.initials: LC
authors.lastname: Foukas
authors.forename: P R
authors.initials: PR
authors.lastname: Shepherd
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D050356:Lipid Metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000502:physiology*; D010766:Phosphorylation; D020033:Protein Isoforms; D015398:Signal Transduction
chemical_list: D004791:Enzyme Inhibitors; D007328:Insulin; D020033:Protein Isoforms; D019869:Phosphatidylinositol 3-Kinases