title: Osteoarticular involvement of brucellosis and HLA-B27 antigen frequency in Turkish patients.
abstract: The aim of the present study is to investigate a possible association between osteoarticular involvement of brucellosis and HLA-B27 antigen. Standard microtoxicity technique method was used for detection of HLA-B27 antigen in 78 patients with brucellosis and 100 healthy donors. Osteoarticular complications were defined in 25 of 78 patients (32.1%). Overall frequency of HLA-B27 in the study group was 14.1% (11/78) and 16% (4/25) in patients with osteoarticular involvement, while it was 8% (8/100) in the control group. Although HLA-B27 frequency in osteoarticular group was slightly higher than both of the other two groups, there was no significant difference (p > 0.05). Conclusively, we could say that further studies including a larger number of patients with osteoarticular involvement of brucellosis may need to be performed in order to find a possible association.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Ankara Training & Research Hospital, Dikimevi-Ankara, Turkey. tuncergunay@yahoo.com
authors.forename: Gunay Tuncer
authors.initials: GT
authors.lastname: Ertem
authors.forename: Esra
authors.initials: E
authors.lastname: Tanyel
authors.forename: Necla
authors.initials: N
authors.lastname: Tulek
authors.forename: Gul B
authors.initials: GB
authors.lastname: Ulkar
authors.forename: Levent
authors.initials: L
authors.lastname: Doganci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002006:Brucellosis / Q000150:complications / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics* / Q000382:microbiology; D014421:Turkey
chemical_list: D015796:HLA-B27 Antigen