title: Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder.
abstract: Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for alpha-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The alpha(1c)-adrenergic (ADRA-1C) receptor gene on 8p21, the alpha(2a)-adrenergic (ADRA-2A) receptor gene on 10q25, and the alpha(2c)-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5'UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5'UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes.
authors.affiliation: Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany. rami.aboujamra@uni-bonn.de
authors.forename: Rami
authors.initials: R
authors.lastname: Abou Jamra
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Astrid
authors.initials: A
authors.lastname: Golla
authors.forename: Carola
authors.initials: C
authors.lastname: Richter
authors.forename: Andreas C J
authors.initials: AC
authors.lastname: Otte
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
authors.forename: Stephanie
authors.initials: S
authors.lastname: Ohlraun
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D001714:Bipolar Disorder / Q000235:genetics*; D002648:Child; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D018562:Disease Transmission, Infectious; D005190:Family; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2