title: A review of post-trachelectomy isthmic and vaginal smear cytology.
abstract: Currently in the UK cervical cancer has a peak incidence in women aged 35-39. Fertility-conserving surgical treatment by radical trachelectomy is established in the management of early disease. This study aimed at establishing the value of cytology in follow-up after trachelectomy. The cytological features of isthmic-vaginal smears post-trachelectomy for cervical cancer are presented together with a discussion of relevant clinical issues. One hundred and ninety seven smears from 32 women were reviewed. Two of the 32 patients developed pelvic recurrences. In both cases recurrence was detected cytologically long before development of a clinical or radiological abnormality. There is, however, a potential for overcall due to the presence of endometrial cells. These were present in large numbers and varying configurations in 58% of smears and led to a false positive report of malignancy in 2% of smears. The rate of referral for a cytologist opinion was significantly higher in smears containing endometrial cells (26%) than those without (13%). While all smears contained squamous cells, 41% contained squamous cells only and it is proposed that such smears should be reported as unsatisfactory in the first 2 years after surgery and negative thereafter, although the absence of glandular cells should be recorded. When an abnormality is reported, smear review and multidisciplinary discussion may avoid unnecessary investigations.
authors.affiliation: Department of Cytology, Barts and the London NHS Trust, St Bartholomew's Hospital London, UK. n.singh@qmul.ac.uk
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: E
authors.initials: E
authors.lastname: Titmuss
authors.forename: J
authors.initials: J
authors.lastname: Chin Aleong
authors.forename: M T
authors.initials: MT
authors.lastname: Sheaff
authors.forename: G
authors.initials: G
authors.lastname: Curran
authors.forename: I J
authors.initials: IJ
authors.lastname: Jacobs
authors.forename: J H
authors.initials: JH
authors.lastname: Shepherd
mesh_terms: D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004717:Endometrium / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D005298:Fertility; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014626:Vaginal Smears