Cortisol and estradiol secretion by a benign virilizing adrenocortical tumor in a prepubertal girl.
We report a 5.5 year-old girl with a benign adrenocortical adenoma who presented with virilization and rapid growth. She did not have any clinical features of isosexual precocity or, except for hypertension, Cushing's syndrome. Measurement of hormones in adrenal vein blood obtained at surgery showed high concentrations of testosterone, cortisol, estradiol and intermediary substrates. Elevated levels of hormones detected in the peripheral blood were released directly from the tumor and were not the result of peripheral interconversion. Hyperandrogenism can obscure the clinical features of Cushing's syndrome and estrogen hypersecretion in patients with functional adrenal tumors.
Ghazi
Ali A M
AA
Endocrine Research Center and Department of Internal Medicine, Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
Mofid
Djafar
D
Rahimi
Farzaneh
F
Sadeghi-Nejad
Ab
A
D000152:Acne Vulgaris / Q000209:etiology; D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D002675:Child, Preschool; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006728:Hormones / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D006973:Hypertension / Q000503:physiopathology; D011629:Puberty, Precocious / Q000209:etiology
D006728:Hormones; D004958:Estradiol; D006854:Hydrocortisone