title: [Evaluation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in peri-implant sulcular fluid].
abstract: OBJECTIVE
  To investigate the levels of MMP-9 and TIMP-1 in healthy and diseased peri-implant tissue.
  
  
  METHODS
  Fifty-one implants in 39 patients were selected and divided into the healthy group and the inflammatory group according to the absence or presence of gingival redness, bleeding on probing, and progressive horizontal absorption of alveolar bone. The clinical parameters included: depth of gingival pocket(PD), plaque & calculus index (PLI), gingival bleeding index (GBI), and MMP-9, TIMP-1 levels in peri-implant sulcular fluid (PISF).
  
  
  RESULTS
  PD, PLI, GBI and MMP-9 levels were significantly higher in inflammatory group than in healthy group (P < 0.001).
  
  
  CONCLUSIONS
  MMP-9 level in PISF was closely associated with the clinical parameters.
authors.affiliation: Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
authors.forename: Shao-heng
authors.initials: SH
authors.lastname: Lu
authors.forename: Xing
authors.initials: X
authors.lastname: Liang
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Xie
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Hui-qiang
authors.initials: HQ
authors.lastname: Sun
mesh_terms: D000328:Adult; D015921:Dental Implants; D004797:Enzyme-Linked Immunosorbent Assay; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000032:analysis*
chemical_list: D015921:Dental Implants; D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9