title: Sclerosing lesions of the breast.
abstract: Sclerosing lesions of the breast often mimic invasive carcinoma at the gross and microscopic levels and can pose a significant diagnostic challenge for surgical pathologists. This brief review is devoted to the histopathological characterization of 2 such sclerosing lesions of the breast: radial scars and sclerosing nipple adenomas. Microscopically, these lesions show similar morphological features: a zonal architectural pattern consisting of a central sclerotic region with entrapped distorted glands and a corona-like peripheral region with associated nonproliferative and proliferative fibrocystic changes. Important diagnostic features of these lesions are highlighted and contrasted with those of invasive carcinoma.
authors.affiliation: James Homer Wright Pathology Laboratories, Molecular Pathology Unit, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Rabban
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Sgroi
mesh_terms: D000236:Adenoma / Q000473:pathology; D001941:Breast Diseases / Q000473:pathology*; D002921:Cicatrix / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D009558:Nipples / Q000473:pathology; D012598:Sclerosis / Q000473:pathology*