title: Volumetry and diffusion tensor imaging of hippocampal subregions in schizophrenia.
abstract: Previous MRI-volumetric studies in schizophrenic psychoses have demonstrated more or less pronounced volume reductions of the hippocampus in patients. Correspondingly, neuropathological examinations on the brains of schizophrenics showed diverse structural changes of the hippocampus. Employing a high-resolution 3D-MPRAGE sequence, we found volume reductions in most hippocampal subregions of schizophrenic patients, which, however, did not reach significant levels. An analysis of co-registered diffusion tensor imaging (DTI) data revealed significant alterations of the inter-voxel coherences in single hippocampal subdivisions of these patients, supporting the assumption of characteristic microstructural tissue changes relevant for the pathogenesis of schizophrenic psychoses. Our results argue for the usage of additional MRI modalities like DTI in order to detect subtle regional alterations of hippocampal structure in schizophrenics.
authors.affiliation: Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland. Peter.Kalus@insel.ch
authors.forename: Peter
authors.initials: P
authors.lastname: Kalus
authors.forename: Caroline
authors.initials: C
authors.lastname: Buri
authors.forename: Johannes
authors.initials: J
authors.lastname: Slotboom
authors.forename: Jan
authors.initials: J
authors.lastname: Gralla
authors.forename: Luca
authors.initials: L
authors.lastname: Remonda
authors.forename: Thomas
authors.initials: T
authors.lastname: Dierks
authors.forename: Werner K
authors.initials: WK
authors.lastname: Strik
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schroth
authors.forename: Claus
authors.initials: C
authors.lastname: Kiefer
mesh_terms: D000328:Adult; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology