title: Effect of choice of measles-mumps-rubella vaccine on immediate vaccination pain in infants.
abstract: OBJECTIVE
  To compare acute pain response to 2 measles-mumps-rubella vaccines.
  
  
  METHODS
  Double-blind clinical trial.
  
  
  METHODS
  Hospital for Sick Children, Toronto, Ontario. Patients Forty-nine infants 12 months of age receiving their first measles-mumps-rubella vaccination.
  
  
  METHODS
  Random allocation to receive Priorix or M-M-R II.
  
  
  METHODS
  Pain responses before (baseline) and after (within 15 seconds) vaccination were quantified by visual analog scale (VAS; range, 0-100), completed by the parent and independently by the pediatrician, and the Modified Behavioral Pain Scale (range, 0-10), scored by a coder blinded to the vaccine allocation. Crying (yes or no) and latency to the first cry after injection were also measured.
  
  
  RESULTS
  Twenty-six infants received Priorix and 23 received M-M-R II. There were no differences between the 2 groups in baseline characteristics or prevaccination baseline pain scores. Median pain scores after vaccination (Priorix vs M-M-R II) were as follows: pediatrician VAS, 15 vs 58 (P =.001); parent VAS, 22 vs 53 (P =.007); and Modified Behavioral Pain Scale, 6 vs 8 (P =.02). Median difference in pain scores (after minus before) for Priorix vs M-M-R II were as follows: pediatrician VAS, 15 vs 53 (P =.003); parent VAS, 22 vs 47 (P =.008); and Modified Behavioral Pain Scale, 3 vs 5 (P =.03). The median latency to first cry was 1.5 seconds in the Priorix group compared with 1 second in the M-M-R II group (P =.26).
  
  
  CONCLUSIONS
  Priorix vaccine causes significantly less pain than M-M-R II at the time of injection for 12-month-old infants receiving their first measles-mumps-rubella vaccination.
authors.affiliation: Hospital for Sick Children, and Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Moshe
authors.initials: M
authors.lastname: Ipp
authors.forename: Eyal
authors.initials: E
authors.lastname: Cohen
authors.forename: Morton
authors.initials: M
authors.lastname: Goldbach
authors.forename: Colin
authors.initials: C
authors.lastname: Macarthur
mesh_terms: D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D010146:Pain / Q000209:etiology*; D010147:Pain Measurement; D014611:Vaccination / Q000009:adverse effects
chemical_list: D022542:Measles-Mumps-Rubella Vaccine