title: UCHL1 is a Parkinson's disease susceptibility gene.
abstract: The reported inverse association between the S18Y variant of the ubiquitin carboxy-terminal hydrolase L1 (UCHL1) gene and Parkinson's disease (PD) has strong biological plausibility. If confirmed, genetic association of this variant with PD may support molecular targeting of the UCHL1 gene and its product as a therapeutic strategy for PD. In this light, we performed a collaborative pooled analysis of individual-level data from all 11 published studies of the UCHL1 S18Y gene variant and PD. There were 1,970 cases and 2,224 unrelated controls. We found a statistically significant inverse association of S18Y with PD. Carriers of the variant allele (Y/Y plus Y/S vs S/S) had an odds ratio (OR) of 0.84 (95% confidence interval [CI], 0.73-0.95) and homozygotes for the variant allele (Y/Y vs S/S plus Y/S) had an OR of 0.71 (95% CI, 0.57-0.88). There was a linear trend in the log OR consistent with a gene dose effect (p = 0.01). The inverse association was most apparent for young cases compared with young controls. There was no evidence for publication bias and the associations remained significant after excluding the first published, hypothesis-generating study. These findings confirm that UCHL1 is a susceptibility gene for PD and a potential target for disease-modifying therapies.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN, USA. dmaraganore@mayo.edu
authors.forename: Demetrius M
authors.initials: DM
authors.lastname: Maraganore
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Lesnick
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbaz
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Chartier-Harlin
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
authors.forename: Rejko
authors.initials: R
authors.lastname: Krüger
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hattori
authors.forename: George D
authors.initials: GD
authors.lastname: Mellick
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Satoh
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Toda
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: John P A
authors.initials: JP
authors.lastname: Ioannidis
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.forename: Walter A
authors.initials: WA
authors.lastname: Rocca
authors.forename: Taksushi
authors.initials: T
authors.lastname: Toda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010300:Parkinson Disease / Q000201:enzymology / Q000235:genetics*; D043222:Ubiquitin Thiolesterase / Q000235:genetics*
chemical_list: D017493:Leukocyte Common Antigens; D043222:Ubiquitin Thiolesterase