title: Curvicollides A-C: new polyketide-derived lactones from a sclerotium-colonizing isolate of Podospora curvicolla (NRRL 25778).
abstract: Curvicollides A-C (1-3) have been obtained from cultures of an isolate of Podospora curvicolla (NRRL 25778) that colonized a sclerotium of Aspergillus flavus. The structures of these compounds were elucidated by analysis of one- and two-dimensional NMR data. The lead compound (1) showed antifungal activity against A. flavus and Fusarium verticillioides. [structure: see text]
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
authors.forename: James B
authors.initials: JB
authors.lastname: Gloer
authors.forename: Donald T
authors.initials: DT
authors.lastname: Wicklow
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota; D001231:Aspergillus flavus / Q000187:drug effects; D005670:Fusarium / Q000187:drug effects; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D048468:Podospora / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D007783:Lactones; C496158:curvicollide A; C496157:curvicollide B; C496156:curvicollide C