Effect of Carisolv on the human dental pulp: a histological study.
OBJECTIVE
The aim of this study was to investigate histopathologically after 1 week and 1 month the effect of Carisolv on exposed human pulp after a contact period of 10 min in comparison to sterile saline solution.


METHODS
Class V cavities were prepared in 40 human first premolars, and the pulp chambers were perforated. The pulp tissue was either exposed to Carisolv or sterile saline solution for 10 min, covered with Teflon and restored with compomer filling material. After observation periods of 1 week and 1 month, the teeth were extracted and examined by light microscopy.


RESULTS
Histological evaluation revealed similar pulpal response which consisted of a slight inflammation in both groups after 1 week. The only difference was localized haemorrhage in controls while no haemorrhage was observed in the test group which may show the haemostatic effect of Carisolv. After 1 month the test teeth displayed a very mild inflammation adjacent to the perforation area while haemorrhage disappeared in the controls. In general, pulps showed structural integrity in both groups. Statistical analysis showed no difference between the test and the control groups in both test periods.


CONCLUSIONS
The results suggest that Carisolv is biocompatible with human pulp tissue and may have a haemostatic effect.
Bulut
Gulcin
G
Department of Paediatric Dentistry, Faculty of Dentistry, Ege University, 35100 Bornova-Izmir, Turkey.
Zekioglu
Osman
O
Eronat
Cemal
C
Bulut
Hakan
H
D000293:Adolescent; D002648:Child; D020770:Compomers / Q000737:chemistry; D003736:Dental Cavity Lining; D003737:Dental Cavity Preparation / Q000145:classification; D003782:Dental Pulp / Q000187:drug effects* / Q000473:pathology; D003789:Dental Pulp Exposure / Q000503:physiopathology; D003793:Dental Restoration, Permanent; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D005500:Follow-Up Studies; D005899:Glass Ionomer Cements / Q000737:chemistry; D018698:Glutamic Acid / Q000494:pharmacology*; D006470:Hemorrhage / Q000473:pathology / Q000517:prevention & control; D006490:Hemostatics / Q000494:pharmacology; D006801:Humans; D007930:Leucine / Q000494:pharmacology*; D008239:Lysine / Q000494:pharmacology*; D009804:Odontoblasts / Q000187:drug effects / Q000473:pathology; D011138:Polytetrafluoroethylene / Q000737:chemistry; D011671:Pulpitis / Q000473:pathology; D012965:Sodium Chloride; D013997:Time Factors
C119934:Carisolv; D020770:Compomers; C118368:F2000 cement; D005899:Glass Ionomer Cements; D006490:Hemostatics; D018698:Glutamic Acid; D012965:Sodium Chloride; D011138:Polytetrafluoroethylene; D007930:Leucine; D008239:Lysine