Quantification of intra-abdominal fat during controlled weight reduction: assessment using the water-suppressed breath-hold MRI technique.
A group of 14 healthy female subjects was studied using MRI during 2 months of life-style intervention. A series of 21 water-suppressed images was used to determine the intra-abdominal fat volume before and after the controlled loss of weight. The average weight decrease was 8.2 %, but the average relative loss of visceral fat was 20.3 %, whereas subcutaneous fat decreased by 13.4 %. A small but significant increase of insulin sensitivity (decrease in fasting insulin and blood glucose) was observed, but no changes in lipoprotein parameters were demonstrated. There was a significant negative correlation (r=-0.633, p=0.028) between the relative abdominal fat decrease and the initial amount of subcutaneous fat.
Tintera
J
J
Institute of Clinical and Experimental Medicine, Vídenská 1958/59, 140 00 Prague 4, Czech Republic. jati@medicon.cz
Harantová
P
P
Suchánek
P
P
Dvoráková
A
A
Adamová
M
M
Hájek
M
M
Poledne
R
R
D000005:Abdomen / Q000033:anatomy & histology*; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004032:Diet; D015930:Diet Records; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007328:Insulin / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009765:Obesity / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D040521:Subcutaneous Tissue / Q000033:anatomy & histology; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio; D014867:Water / Q000737:chemistry; D015431:Weight Loss / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D008074:Lipoproteins; D014280:Triglycerides; D014867:Water; D002784:Cholesterol