alpha4beta2 nACh receptor pharmacophore models.
Progress towards the development of alpha4beta2 nicotinic acetylcholinergic receptor pharmacophores is reviewed from the early Beers and Riech model to the newer vector models.
Glennon
Richard A
RA
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA. glennon@hsc.vcu.edu
Dukat
Małgorzata
M
D000818:Animals; D015195:Drug Design; D006860:Hydrogen Bonding; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
D008024:Ligands; D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2