title: Assessment of cardiovascular parameters during dental procedures under the effect of benzodiazepines: a double blind study.
abstract: The purpose of this study was to evaluate cardiovascular parameters during dental procedures: systolic, diastolic, and mean blood pressures, and heart rate. Nineteen healthy normotensive patients (18-56 years of age) received restorative treatment on three maxillary molars. The patients were continuously monitored by a non-invasive automatic monitor for blood pressure and heart rate during the pre-, trans-, and post-operative periods at the following stages: 15 min prior to anesthesia; during topical anesthesia; during infiltrative anesthesia; for 5 minutes immediately after; during cavity preparation; during restorative procedure; for 10 min after completion. Patients were divided into three groups: A (without pre-medication), B (preceded by 10 mg diazepam), and C (preceded by placebo). All patients received infiltrative anesthesia containing 1.8 mL of 2% lidocaine (36 mg) with epinephrine 1:100,000 (18 microg). There were no changes in the parameters during the clinical procedures. When groups were compared, there were significant differences in diastolic arterial pressures during anesthesia.
authors.affiliation: Department of Stomatology, Faculty of Dentistry, University of São Paulo, São Paulo, SP, Brazil. fatimafaraco@terra.com.br
authors.forename: Fatima Neves
authors.initials: FN
authors.lastname: Faraco
authors.forename: Paschoal Laércio
authors.initials: PL
authors.lastname: Armonia
authors.forename: José Leonardo
authors.initials: JL
authors.lastname: Simone
authors.forename: Nicolau
authors.initials: N
authors.lastname: Tortamano
mesh_terms: D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000008:administration & dosage; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D003729:Dental Care; D003731:Dental Caries / Q000628:therapy; D003737:Dental Cavity Preparation; D003793:Dental Restoration, Permanent; D003971:Diastole; D003975:Diazepam / Q000627:therapeutic use*; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011229:Preanesthetic Medication; D013599:Systole; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D014151:Anti-Anxiety Agents; D010919:Placebos; D014662:Vasoconstrictor Agents; D008012:Lidocaine; D003975:Diazepam; D004837:Epinephrine