[Age dynamics of the activity of the imago after chronic irradiation of larvae from the Drosophila line with disruption of apoptosis regulation].
The relationship was studied between radiation-induced apoptosis in the nervous system of Drosophila larvae and the age dynamics in adult fly neuromuscular activity. The level of apoptosis in the neural ganglia of third-instar larvae from the wild-type strain increased 2.5 times after larval exposure to ionizing radiation (54 cGy). Irradiation of the strain with enhanced sensitivity to apoptosis induction, which carries a mutation in gene-inhibitor of apoptosis th (allele th4), and the wild-type strain Berlin led to an increase in neuromuscular activity of adult flies throughout the experiment and, consequently, to reduced aging rate. Conversely, this effect was not observed in strains with reduced sensitivity to induction of apoptosis (with mutations in genes dArk and Dcp-1).
Moskalev
A A
AA
Institute of Biology, Komi Research Center, Russian Academy of Sciences, Syktyvkar, 167983 Russia. moskalev@ib.komisc.ru
Zaĭnullin
V G
VG
D000483:Alleles; D000818:Animals; D017209:Apoptosis; D004330:Drosophila / Q000166:cytology / Q000254:growth & development*; D007814:Larva / Q000502:physiology / Q000528:radiation effects*