title: Functionalised enones as starting materials for the construction of aziridine scaffolds.
abstract: alpha-Substituted beta-keto esters have been transformed by means of a straightforward procedure into aziridine-1,2-dicarboxylates, which have been efficiently converted into alkenyl aziridine-1,2-dicarboxylates through Wittig olefination reaction. The possibility of aziridine ring elaborations and the presence of an olefin function make these new molecules suitable scaffolds for further derivatisation into potential bioactive targets.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Roma "La Sapienza", P.le Aldo Moro 2, 1-00185 Roma, Italy. stefania.fioravanti@uniroma1.it
authors.forename: Stefania
authors.initials: S
authors.lastname: Fioravanti
authors.forename: Alberto
authors.initials: A
authors.lastname: Morreale
authors.forename: Lucio
authors.initials: L
authors.lastname: Pellacani
authors.forename: Paolo A
authors.initials: PA
authors.lastname: Tardella
mesh_terms: D001388:Aziridines / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001388:Aziridines; D007659:Ketones; C033132:aziridine