title: Radical carboazidation: expedient assembly of the core structure of various alkaloid families.
abstract: A procedure for one-pot intermolecular radical addition of 2-iodoesters to terminal alkenes followed by azidation of the radical adduct has been developed. This sequential reaction represents an alkene carboazidation process. Its efficacy is demonstrated by the two-step preparation of various lactams such as pyrrolidinones, pyrrolizidinones, and indolizidinones. An easy access to spirolactams bearing an amino-substituted quaternary carbon center is also described. These compounds are important building blocks for the synthesis of numerous alkaloids such as, for instance, FR901483.
authors.affiliation: University of Berne, Department of Chemistry and Biochemistry, CH-3012 Berne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Panchaud
authors.forename: Cyril
authors.initials: C
authors.lastname: Ollivier
authors.forename: Philippe
authors.initials: P
authors.lastname: Renaud
authors.forename: Sarunas
authors.initials: S
authors.lastname: Zigmantas