HLA-B57 is significantly associated with psoriasis in Northeast Romania [corrected].
The aim of the study was to identify HLA class I types associated with susceptibility to psoriasis among population of Northeast region of Romania.


METHODS
27 psoriatic patients and 89 controls were typed serologically for HLA-A and HLA-B lymphocyte expression using CDC-NIH (complement dependent-cytotoxicity--National Institute of Health) method. The Terasaki plates used for HLA class I typing were prepared in our laboratory using antisera of known specificities.


CONCLUSIONS
psoriatic patients in the group of study frequently express HLA-B57 phenotype. The relative risk induced by this phenotype was highly statistically significant (p = 0.0016) while HLA-B13 was not associated with a significant risk for developing psoriasis in patients under study compared with controls (p = 0.48). Also, HLA-B27 (p = 0.96) and HLA-B44 (p = 0.99), reported by others to be associated with late psoriasis, do not meet (a particular) disease susceptibility between psoriatic patients under investigation.
Vasilca
Venera
V
Gr. T. Popa University of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Iaşi, Romania.
Vasilca
A
A
Munteanu
Dorina
D
Constantinescu
Daniela
D
Livideanu
Cristina
C
Tepeluş
Maria
M
Zugun
F
F
Carasevici
E
E
D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000235:genetics*; D012383:Romania
D015235:HLA-B Antigens; C103707:HLA-B57 antigen