[Neuropsychiatric complication after surgical procedures--literature review].
2-3% of patients after cardiac procedures with the use of cardiopulmonary by-pass develop neurological complications with focal symptoms. Also to there may be mental, emotional and intellectual disturbances. This kind of complications occurs in 33-83% of patients. The post-cardiopulmonary by-pass delirium is a syndrome with diverse symptoms. Confusion, hallucinations, paranoid illusions, psycho-motoric excitation, fear may also occur. A high level of serotonin and overstimulation of 5-HT2 receptors in the central nervous system are the reason of delirium. The relief of symptoms may be achieved by intravenous administration of Ondansetron, an antagonist of 5-HT2 receptors.
Czech
Bronisław
B
Kliniki Kardiochirurgii i Transplantologii Slaskiego Centrum Chorób Serca w Zabrzu.
Kucewicz
Ewa
E
Frank
Marek
M
D014150:Antipsychotic Agents / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures / Q000009:adverse effects* / Q000523:psychology*; D003693:Delirium / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D001523:Mental Disorders / Q000209:etiology*; D009422:Nervous System Diseases / Q000209:etiology*; D017294:Ondansetron / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use
D014150:Antipsychotic Agents; D012702:Serotonin Antagonists; D017294:Ondansetron