title: Bile duct changes in rats reinfected with Clonorchis sinensis.
abstract: This study describes an evaluation of the sonographic, cholangiographic, pathological, and immunological findings, and the protective effect shown by rats reinfected with Clonorchis sinensis. Eight experimental rat groups were, namely, a normal control, a primary infection control, a reinfection I (reinfection 7 week after treatment following 3-week infection), a reinfection II (reinfection 2 week after treatment following 8-week infection), a reinfection III (exploration of the intrahepatic bile ducts 1 week after reinfection 4 week after treatment following 4-week infection), a superinfection, a secondary infection control, and an infection following immunization group. Sonographic and cholangiographic findings showed moderate or marked dilatation of the bile duct confluence in the primary infection control, reinfection II, and secondary infection control groups. Juvenile worms survived in the intrahepatic bile ducts 1 week after reinfection following treatment in the reinfection III group. It was concluded that reinfecting juvenile worms found during the first week following reinfection failed to survive or grow further. Anatomical, pathophysiological, or immunological changes may induce protection from reinfection in rats.
authors.affiliation: Department of Parasitology and Tropical Medicine, Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Dongil
authors.initials: D
authors.lastname: Choi
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Hong
authors.forename: Shunyu
authors.initials: S
authors.lastname: Li
authors.forename: Byung-Suk
authors.initials: BS
authors.lastname: Chung
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lim
authors.forename: Soon-Hyung
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000097:blood; D000947:Antigens, Helminth / Q000008:administration & dosage / Q000276:immunology; D001649:Bile Duct Diseases / Q000000981:diagnostic imaging / Q000469:parasitology / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging / Q000469:parasitology / Q000473:pathology*; D002758:Cholangiography; D003003:Clonorchiasis / Q000000981:diagnostic imaging / Q000469:parasitology / Q000473:pathology*; D003004:Clonorchis sinensis / Q000472:pathogenicity*; D007114:Immunization; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013018:Sound Spectrography; D014463:Ultrasonography
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D011223:Praziquantel