title: [Effect of LFA-1 expression on neutrophils and serum level of soluble ICAM-1 in patients with chronic myelogenous leukemia].
abstract: The aim of this study was to estimation of LFA-1 expression on PMN and concentration of sICAM-1 in serum patients with chronic myelogenic leukemia. The results indicate on increased expression of LFA-1 on isolated neutrophils from peripheral blood of patients with chronic myelogenic leukemia. A concentration of sICAM was increased in serum patients with chronic myelogenic leukemia either. High expression of adhesion molecules can make easier binding neoplasmatic cells to LFA-1 and facilitate their migration to other tissues (distant metastases). On the other hand, soluble forms of ICAM can block connection neoplasmatic cells to membrane forms of adhesion molecules. Probably, the balance between membrane--bound and soluble forms of adhesion molecules is responsible for malignancy progression.
authors.affiliation: Klinika Hematologii Akademii Medycznej w Białymstoku.
authors.forename: Beata
authors.initials: B
authors.lastname: Kiersnowska-Rogowska
authors.forename: Aneta
authors.initials: A
authors.lastname: Izycka
authors.forename: Ewa
authors.initials: E
authors.lastname: Jabłońska
authors.forename: Franciszek
authors.initials: F
authors.lastname: Rogowski
authors.forename: Adam
authors.initials: A
authors.lastname: Parfieńczyk
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D016169:Lymphocyte Function-Associated Antigen-1; D018799:Intercellular Adhesion Molecule-1