Fibromuscular dysplasia of the renal artery responsible for renovascular hypertension: a histological presentation based on a series of 102 patients.
BACKGROUND
Fibromuscular dysplasia (FMD) is a rare non-atherosclerotic and non-inflammatory disease in the arterial system. The purpose of the study was a retrospective analysis of FMD in the renal artery.


METHODS
A total number of 102 patients (mean age: 36.9 years) who suffered from renovascular hypertension underwent a surgical therapy. The operative specimens of the renal arteries were analysed with the lightmicroscop using histological and immunohistochemical methods.


RESULTS
101 patients (99.02%) presented a medial FMD (extensive-medial subtype in 56 patients, 54.9%, subadventitial subtype in 29 patients, 28.4% and combined subtype in 16 patients, 15.7%). In 1 patient (0.98%) an adventitial FMD was found. We observed the following complications: true and dissecting aneurysms (75 patients, 74.5%), arterio-venous fistulae (2 patients, 1.96%) and chronic thrombosis (10 patients, 9.8%).


CONCLUSIONS
With the progress in angioplasty, not all patients suffering from FMD undergo a primary surgical therapy and therefore this lesion is less seen in the daily work of the histopathologist.
Vuong
P N
PN
Unité d'Anatomie et de Cytologie Pathologiques, Hôpital Saint-Michel, Paris, France.
Desoutter
P
P
Mickley
V
V
Bültmann
B
B
Rothenberger-Janzen
K
K
Guyot
H
H
Janzen
J
J
D000328:Adult; D003893:Desmin / Q000032:analysis; D005260:Female; D005352:Fibromuscular Dysplasia / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006977:Hypertension, Renal / Q000473:pathology* / Q000601:surgery; D007672:Kidney Cortex / Q000098:blood supply / Q000473:pathology; D008875:Middle Aged; D032342:Muscle Cells / Q000473:pathology; D009392:Nephrectomy; D012077:Renal Artery / Q000473:pathology / Q000601:surgery; D012078:Renal Artery Obstruction / Q000473:pathology* / Q000601:surgery
D003893:Desmin