[Clinical observation on effect of yangxue qingnao granule in treating patients with cerebral arteriosclerosis].
OBJECTIVE
To observe the efficacy of Yangxue Qingnao granule (YXQN) in treating cerebral arteriosclerosis and to explore its mechanisms.


METHODS
One hundred and sixty-seven patients with arteriosclerosis were randomly divided into the treated group treated with conventional medical treatment plus YXQN and the control group treated with conventional medical treatment alone, to observe the changes before and after treatment in scores of chief symptoms, mean velocity of cerebral blood flow (VM), plasma nitric oxide (NO), calcitonin gene related peptide (CGRP) and endothelin (ET) levels.


RESULTS
(1) After treatment in treated group, the scores of chief symptoms such as vertigo, headache and tinnitus were significantly lower than those in the control group (P < 0.05 or P < 0.01); (2) NO and CGRP level in the treated group after treatment obviously elevated, and ET and VM markedly reduced (P < 0.01), while no evident change of these parameters was found in the control group (P < 0.01).


CONCLUSIONS
The efficacy of YXQN in treating cerebral arteriosclerosis is definite, modulating the level of vasoactive factors was its important mechanism.
Wang
Yan-jiang
YJ
Second Cerebral Department, Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042. wayaja@yahoo.com
Zhou
Hua-dong
HD
Li
Jing-cheng
JC
D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D002536:Cerebral Arteries / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D005260:Female; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy
D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide; D015740:Calcitonin Gene-Related Peptide