A comparison of drug loading capacity of cellactose with two ad hoc processed lactose-cellulose direct compression excipients.
This study compares the drug loading capacity of Cellactose and two excipients of similar composition and similar particle size, prepared by dry granulation and extrusion-spheronization respectively. The drugs evaluated were acetaminophen and furosemide. Acetaminophen did not significantly affect the flow properties of any of the excipients, whereas furosemide markedly worsened flow properties, eliminating the differences initially existing among the three excipients. For both drugs, tablet mechanical properties were clearly better with Cellactose than with the other excipients. Acetaminophen dissolution rate was very similar regardless of the excipient used, but furosemide dissolution rate was lower from Cellactose tablets than from tablets prepared with the other excipients. This important difference is discussed in terms of micropore structure, specific surface area, and wettability of tablets, and is attributable to the special structure of Cellactose particles.
Casalderrey
Marta
M
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Souto
Consuelo
C
Concheiro
Angel
A
Gómez-Amoza
José Luis
JL
Martínez-Pacheco
Ramón
R
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D004232:Diuretics / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D005665:Furosemide / Q000008:administration & dosage / Q000737:chemistry; D007700:Kinetics; D007785:Lactose / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D012995:Solubility; D013499:Surface Properties; D013607:Tablets; D013718:Tensile Strength
D004232:Diuretics; D005079:Excipients; D013607:Tablets; D000082:Acetaminophen; D005665:Furosemide; D002482:Cellulose; D008628:Mercury; D007785:Lactose