title: The psychological aspects of noncardiac chest pain.
abstract: There is some evidence to support a psychosocial link to GERD,although it is a weak one. The little research that has been done in this area is, in general, poor and inconclusive. Better designed studies must be done. The elements that seem to offer the best possibilities for research in GERD are the psychological variables involved in care seeking and the variations between care seekers and non-care seekers. In addition, research on psychosocial predictors of response to proton pump inhibitors, prokinetic agents, and antidepressants and other pain-modulating drugs need to be better understood. The psychosocial link to NCCP is stronger with regard to panic disorder,but much research needs to be done. Despite the paucity of well done,rigorously controlled studies in NCCP patients, that there is a high prevalence of psychiatric disturbance in this group. Parental health and childhood trauma are intriguing areas for further research, particularly in light of the connection between abuse and IBS and other functional GI disorders.Finally, panic disorder has been established as an important comorbidity of NCCP. It also merits more research, particularly into the pathophysiology that may link these two disorders.
authors.affiliation: Department of Gastroenterology, Mayo Clinic, 13400 East Shea Blvd., Scottsdale, AZ 85259, USA. olden.kevin@mayo.edu
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Olden
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D002637:Chest Pain / Q000188:drug therapy / Q000209:etiology / Q000523:psychology*; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D001523:Mental Disorders / Q000150:complications; D016584:Panic Disorder / Q000150:complications; D015995:Prevalence
chemical_list: D000928:Antidepressive Agents