Thyroid function in patients with Alzheimer's disease treated with cholinesterase inhibitors.
The aim of the present study was to explore a possible interplay between cholinesterase inhibitors (ChEIs) and thyroid function tests (TFTs) in patients with Alzheimer's disease (AD). We reviewed thyroid function tests in 19 patients with AD before and after treatment (Rx) with ChEIs. Immunoradiometric assays were used for measuring serum thyrotropin, free thyroxin (FT4) and free triiodothyronine (FT3). Significant differences were observed among FT3 levels according to the duration of therapy. Subtle variations in thyroid function tests--before and after therapy--could be possibly related to ChEIs-induced altered thyroid function.
Kapaki
Elisabeth
E
Athens National University, Medical School, Department of Neurology, Eginition Hospital, Athens GR-11528, Greece. ekapaki@med.uoa.gr.
Ilias
Ioannis
I
Paraskevas
George P
GP
Theotoka
Ioulia
I
Christakopoulou
Ioulia
I
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects*; D013963:Thyroid Hormones / Q000097:blood
D002800:Cholinesterase Inhibitors; D013963:Thyroid Hormones