title: Association between Epstein-Barr virus and classic Hodgkin lymphoma in Jordan: a comparative study with Epstein-Barr virus-associated Hodgkin lymphoma in North America.
abstract: An association between Epstein-Barr virus and Hodgkin lymphoma has been shown in several parts of the world. The reported incidence of Epstein-Barr virus in Hodgkin lymphoma varies significantly from one country to another and ranges from <30% in Swedish patients to 100% in patients from Kenya. Using in situ hybridization for detection of Epstein-Barr virus-encoded RNA and immunohistochemistry for detection of Epstein-Barr virus latent membrane protein, we analyzed 28 cases of Hodgkin lymphoma from Jordan and 30 cases from the United States. Eight of 28 Jordanian cases and 9 of 30 North American cases were Epstein-Barr virus positive. Our studies show that the incidence of Epstein-Barr virus among Jordanian patients with Hodgkin lymphoma is similar to the rate in patients from the United States. This rate appears to be low to intermediate compared with rates in other parts of the world.
authors.affiliation: Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA 52241, USA. mohammad-vasef@uiowa.edu
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Vasef
authors.forename: Manaf A
authors.initials: MA
authors.lastname: Ubaidat
authors.forename: Hasan S
authors.initials: HS
authors.lastname: Khalidi
authors.forename: Nidal M
authors.initials: NM
authors.lastname: Almasri
authors.forename: Mousa
authors.initials: M
authors.lastname: Al-Abbadi
authors.forename: Hassan Z
authors.initials: HZ
authors.lastname: Annab
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000378:metabolism; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D015994:Incidence; D007597:Jordan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009656:North America / Q000453:epidemiology; D014763:Viral Matrix Proteins / Q000378:metabolism
chemical_list: D000956:Antigens, Viral; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins