title: [Studies of radiosensitizative effect of BSO on Acc-2 cells]
abstract: OBJECTIVE:To study the radiosensitizative effect of buthione sulfoximin (BSO) on Acc-2 cells.METHODS:First,the pharmotoxicity of BSO to Acc-2 cells under hypoxic or aerobic conditions was measured.Second,the radiosensitizative effect of BSO on Acc-2 cells under hypoxic or aerobic conditions was studied.Plating efficiency assay was used in this experiment.RESUTS:The 50% inhibition dose (ID50) of BSO to Acc-2 cells under hypoxic or aerobic condition was 80 micromol/L,120micromol/L,respectively.When the dose of BSO was ID20 and ID10 under hypoxic or aerobic condition the SER was 1.521,1.263 and 1.296,1.153,respectively.CONCLUSION:BSO had radiosensitizative effect on Acc-2 cells both under hypoxic or aerobic condition.The radiosensitizative effect of BSO on Acc-2 cells under hypoxic condition was stronger than that under aerobic condition.
authors.affiliation: Department of Oral & Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University. Shanghai 200011  China.
authors.forename: G Y
authors.initials: GY
authors.lastname: Wan
authors.forename: G C
authors.initials: GC
authors.lastname: Lin
authors.forename: Z H
authors.initials: ZH
authors.lastname: Wang
authors.forename: W T
authors.initials: WT
authors.lastname: Chen