Asymmetric catalysis using self-assembled chiral bidentate P,P-ligands.
A strategy is described for modular catalyst development based upon metal-directed self-assembly of bifunctional subunits around a structural metal to form a heteroleptic complex in which a second set of ligating groups are now suitably disposed to bind a second metal to form a catalytic site. A library of chiral diphosphites was prepared via metal-directed self-assembly and used in a simple asymmetric allylic amination, giving enantiomeric excesses as high as 97%.
Takacs
James M
JM
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA. jtakacs1@unl.edu
Reddy
D Sahadeva
DS
Moteki
Shin A
SA
Wu
Di
D
Palencia
Hector
H