title: Enzymatic synthesis of multi-component copolymers and their structural characterization.
abstract: The use of enzymes in synthetic applications has increased dramatically in the recent years and the field of polymer science is part of this trend. Synthesis of a variety of polymers using lipase catalyzed (Candida antarctica) polymerization reactions has led to a variety of new materials with interesting properties in our laboratories. This paper describes the synthesis of multi-component polyesters and mixed polymers having polyester and polyamide linkages under solvent-less conditions using Candida antarctica lipase B. The effect of a third component, i.e. a series of 1,omega-alkanediols (1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, 1,10-decanediol, 1,12-dodecanediol, 1,14-tetradecanediol and 1,16-hexadecanediol) on the copolymerization reaction of dimethyl 5-hydroxyisophthalate with poly(ethylene glycol 600) has been studied and the mechanism for the incorporation of the third component is proposed. We have also studied the effect of different functional groups during terpolymerization reaction of dimethyl 5-hydroxyisophthalate with poly(ethylene glycol) by adding a third component having different functionalities (1,6-hexanediol, 1,6-hexanediamine or 1,6-hexanedithiol) and compared the effect of hydroxyl, amine and thiol groups on the polymerization reactions.
authors.affiliation: Institute for Nano Science and Engineering Technology, Department of Chemistry, University of Massachusetts Lowell, MA 01854, USA.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Rahul
authors.initials: R
authors.lastname: Tyagi
authors.forename: Virinder S
authors.initials: VS
authors.lastname: Parmar
authors.forename: Lynne A
authors.initials: LA
authors.lastname: Samuelson
authors.forename: Jayant
authors.initials: J
authors.lastname: Kumar
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Watterson
mesh_terms: D002175:Candida / Q000201:enzymology*; D005656:Fungal Proteins; D008049:Lipase / Q000378:metabolism*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D012997:Solvents
chemical_list: D005656:Fungal Proteins; D011091:Polyesters; D011108:Polymers; D012997:Solvents; D011092:Polyethylene Glycols; D008049:Lipase; C431349:lipase B, Candida antarctica