Interplay between alpha/beta and gamma interferons with B, T, and natural killer cells in the defense against herpes simplex virus type 1.
The essential components of the immune system that control primary and chronic infection with herpes simplex virus type 1 (HSV-1) in mice were investigated. Infection within the first few days can be controlled by alpha/beta interferon (IFN-alpha/beta) alone without significant contribution of B, T, or NK cells. IFN-alpha/beta and IFN-gamma cooperate in the elimination of virus in the absence of these lymphocytes. In contrast, B, T, or NK cells appear to be required to control persistent infection with HSV-1. These results suggest that distinct and essential immune elements are recruited in a time-dependent fashion to control acute and persistent HSV-1 infection.
Vollstedt
Sabine
S
Institute of Virology, University of Zurich, Zurich, Switzerland.
Arnold
Susi
S
Schwerdel
Cornelia
C
Franchini
Marco
M
Alber
Gottfried
G
Di Santo
James P
JP
Ackermann
Mathias
M
Suter
Mark
M
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002494:Central Nervous System Infections / Q000276:immunology / Q000821:virology; D004279:DNA, Viral / Q000302:isolation & purification; D006561:Herpes Simplex / Q000276:immunology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D007372:Interferons / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology*; D008565:Membrane Proteins; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology; D000096743:Interferon gamma Receptor
D004279:DNA, Viral; D007372:Interferons; D008565:Membrane Proteins; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor