title: Crohn's disease post-cardiac transplantation presenting with severe growth failure and delayed onset of puberty.
abstract: We report a 15 yr-old girl who 10 yr post-cardiac transplantation presented with severe growth failure and delayed onset of puberty. She was found to have pan-enteric Crohn's disease and has done remarkably well on principally nutritional therapy with a significant growth spurt and the onset of menarche. The development of bowel disease whilst on immunosuppression is rare and the literature is reviewed.
authors.affiliation: Paediatric Medical Unit, Southampton General Hospital, Southampton, Hampshire, UK.
authors.forename: Bettina
authors.initials: B
authors.lastname: Harms
authors.forename: A Ronald
authors.initials: AR
authors.lastname: Bremner
authors.forename: Jean
authors.initials: J
authors.lastname: Mulligan
authors.forename: Joanna
authors.initials: J
authors.lastname: Fairhurst
authors.forename: D Mervyn
authors.initials: DM
authors.lastname: Griffiths
authors.forename: Tony
authors.initials: T
authors.lastname: Salmon
authors.forename: R Mark
authors.initials: RM
authors.lastname: Beattie
mesh_terms: D000293:Adolescent; D003424:Crohn Disease / Q000150:complications / Q000503:physiopathology*; D004750:Enteral Nutrition / Q000379:methods; D005260:Female; D006130:Growth Disorders / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents; D011183:Postoperative Complications; D011628:Puberty, Delayed / Q000178:diet therapy* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents