title: Basal joint osteoarthritis of the thumb: a prospective trial of steroid injection and splinting.
abstract: OBJECTIVE
  There have been few prospective studies evaluating the results of nonsurgical treatment of a well-defined patient cohort with symptomatic basal joint osteoarthritis of the thumb. This prospective study uses a validated outcome instrument to examine the effectiveness of a single steroid injection and 3 weeks of splinting in patients with osteoarthritis in Eaton stages 1 to 4 with a minimum of 18 months of follow-up evaluation.
  
  
  METHODS
  Thirty consecutive patients (30 thumbs) were studied prospectively to evaluate the efficacy of a single injection of corticosteroid into the trapeziometacarpal joint, followed by immobilization in a thumb spica splint for 3 weeks. All patients answered an outcome-based questionnaire (Disabilities of the Arm, Shoulder, and Hand) and were examined before injection, 6 weeks after injection, and at final follow-up examination (minimum, 18 months). Eaton radiographic stage was recorded by 3 independent observers.
  
  
  RESULTS
  At 6 weeks 13 patients had improvement in pain intensity and 17 patients reported no symptomatic improvement. Twelve of those with relief at 6 weeks continued to have relief at long term follow-up evaluation (mean, 25 months). Of patients with long-term relief average grip strength of the affected thumb was 95% of contralateral side, whereas those without relief had grip strength values that were 60% of contralateral side. For those patients without relief at 6 weeks there was no improvement seen at later follow-up evaluation. Five patients with Eaton stage 1 disease had an average of 23 months of relief with nonsurgical treatment. In stage 2 and stage 3 disease 7 thumbs improved at 6 weeks after injection and 6 thumbs had long-term relief. In stage 4 disease, 6 thumbs had neither short-term nor long-term relief with the injection. Disease side, handedness, and smoking did not affect outcomes. At final follow-up evaluation 12 thumbs had had surgical treatment.
  
  
  CONCLUSIONS
  Steroid injection with splinting for the treatment of basal joint arthritis of the thumb provided reliable long-term relief in thumbs with Eaton stage 1 disease but provided long-term relief in only 7 of 17 thumbs with Eaton stage 2 and stage 3 basal joint arthritis.
authors.affiliation: Department of Orthopaedic Surgery, Washington University at Barnes-Jewish Hospital, One Barnes Hospital Plaza, St Louis, MO 63110, USA.
authors.forename: Charles S
authors.initials: CS
authors.lastname: Day
authors.forename: Richard
authors.initials: R
authors.lastname: Gelberman
authors.forename: Alpesh A
authors.initials: AA
authors.lastname: Patel
authors.forename: Molly T
authors.initials: MT
authors.lastname: Vogt
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Ditsios
authors.forename: Martin I
authors.initials: MI
authors.lastname: Boyer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000077555:Methylprednisolone Acetate; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D011859:Radiography; D013165:Splints; D013933:Thumb / Q000000981:diagnostic imaging; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone