Effect of modified ultrafiltration on inflammatory mediators, coagulation factors, and other proteins in blood after an extracorporeal circuit.
Modified ultrafiltration (MUF) is a technique able to remove the excess body fluid and inflammatory mediators associated with the use of a cardiopulmonary bypass (CPB). It has been shown to reduce morbidity after cardiac operations in children. Application of MUF after adult cardiac operations has also been suggested being associated with a lower prevalence of early morbidity. However, the relationship between the concentration of mediators in the blood and postoperative morbidity remains yet to be proved. In this study, changes of various chemical mediators in the filtrate and blood before and after MUF have been evaluated in adult patients. Significant reductions of blood levels of inflammatory cytokines were not observed after MUF. On the other hand, MUF significantly elevated hematocrit, number of red cells, concentrations of albumine, coagulation Factor VII and X, platelet factor (PF)-4, and antithrombin (AT-) III.
Fujita
Masanori
M
Department of Surgery II, Research Institute, National Defense Medical College, Saitama, Japan. BXB01424@nifty.ne.jp
Ishihara
Masayuki
M
Kusama
Yoshimasa
Y
Shimizu
Masafumi
M
Kimura
Tamizo
T
Iizuka
Yasuhiro
Y
Ozaki
Shigeyuki
S
Muraoka
Masato
M
Morimoto
Yuji
Y
Takeshima
Shigeto
S
Kikuchi
Makoto
M
Maehara
Tadaaki
T
D001773:Blood Cells / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000032:analysis*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002318:Cardiovascular Diseases / Q000601:surgery; D013504:Cardiovascular Surgical Procedures / Q000379:methods; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D014462:Ultrafiltration / Q000379:methods*
D001779:Blood Coagulation Factors; D018836:Inflammation Mediators