title: Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
abstract: BACKGROUND
  One case of leiomyosarcoma and one case of gastrointestinal stromal tumor with prominent osteoclast-like giant cells have so far been reported in the digestive tract.
  
  
  OBJECTIVE
  To ascertain the clinicopathologic features and biologic behavior of these tumors, we report 3 additional cases of leiomyosarcoma of the gastrointestinal tract and one malignant gastrointestinal stromal tumor.
  
  
  METHODS
  Histologic and immunohistochemical examinations were performed. Clinical and follow-up data were recorded, and the literature was reviewed.
  
  
  RESULTS
  The age of the patients ranged from 50 to 68 years (mean, 62 years). One of the lesions arose in the stomach, one in the ileum, and 2 in the colon. Three tumors showed a strong positivity for muscle actin and desmin and were diagnosed as leiomyosarcomas, 2 of them showing spindle cells and 1 of them showing epithelioid cells. The fourth tumor reacted strongly positive for c-Kit (CD117) and vimentin, and it was diagnosed as an epithelioid malignant gastrointestinal stromal tumor. All tumors were characterized by numerous osteoclast-like giant cells that were unevenly distributed and that, using immunohistochemistry, reacted strongly with CD68.
  
  
  CONCLUSIONS
  Malignant stromal tumors with osteoclast-like giant cells of the gastrointestinal tract are rare entities, are more commonly of a myogenic origin such as leiomyosarcoma, and seem to have an aggressive behavior.
authors.affiliation: Dipartimento di Anatomia Patologica, Facolta di Medicina, Universita Federico II, Napoli, Italy. insabato@unina.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Insabato
authors.forename: Dolores
authors.initials: D
authors.lastname: Di Vizio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciancia
authors.forename: Guido
authors.initials: G
authors.lastname: Pettinato
authors.forename: Luigi
authors.initials: L
authors.lastname: Tornillo
authors.forename: Luigi
authors.initials: L
authors.lastname: Terracciano
mesh_terms: D000199:Actins / Q000032:analysis; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003110:Colonic Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D015726:Giant Cells / Q000648:ultrastructure; D006801:Humans; D007078:Ileal Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D007890:Leiomyosarcoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000032:analysis; D010010:Osteoclasts / Q000648:ultrastructure; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D012189:Retrospective Studies; D012509:Sarcoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D013274:Stomach Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D003893:Desmin; D009363:Neoplasm Proteins; D014746:Vimentin; D019009:Proto-Oncogene Proteins c-kit