title: Enhanced ultrasound transmission through the human skull using shear mode conversion.
abstract: A new transskull propagation technique, which deliberately induces a shear mode in the skull bone, is investigated. Incident waves beyond Snell's critical angle experience a mode conversion from an incident longitudinal wave into a shear wave in the bone layers and then back to a longitudinal wave in the brain. The skull's shear speed provides a better impedance match, less refraction, and less phase alteration than its longitudinal counterpart. Therefore, the idea of utilizing a shear wave for focusing ultrasound in the brain is examined. Demonstrations of the phenomena, and numerical predictions are first studied with plastic phantoms and then using an ex vivo human skull. It is shown that at a frequency of 0.74 MHz the transskull shear method produces an amplitude on the order of--and sometimes higher than--longitudinal propagation. Furthermore, since the shear wave experiences a reduced overall phase shift, this indicates that it is plausible for an existing noninvasive transskull focusing method [Clement, Phys. Med. Biol. 47(8), 1219-1236 (2002)] to be simplified and extended to a larger region in the brain.
authors.affiliation: Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02145, USA.
authors.forename: G T
authors.initials: GT
authors.lastname: Clement
authors.forename: P J
authors.initials: PJ
authors.lastname: White
authors.forename: K
authors.initials: K
authors.lastname: Hynynen
mesh_terms: D000042:Absorption; D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D015519:Bone Density / Q000502:physiology*; D006801:Humans; D008962:Models, Theoretical; D012886:Skull / Q000000981:diagnostic imaging* / Q000502:physiology*; D014057:Tomography, X-Ray Computed; D014465:Ultrasonics; D014463:Ultrasonography