Effect of glucocorticoids on 3-nitropropionic acid-induced oxidative stress in synaptosomes.
The present study with rat striatal and cortical synaptosomes evaluated the effect of dexamethasone (300 microg/kg i.p./day) with and without simultaneous adrenalectomy on the oxidative stress induced by 3-nitropropionic acid (20 mg/kg/day for 4 days). Adrenalectomy enhanced the oxidative stress induced by 3-nitropropionic acid. These changes were prevented by previous and simultaneous administration of dexamethasone. Adrenalectomy alone induced oxidative stress with decreases in succinate dehydrogenase activity. Our results revealed that adrenal glucocorticoids, and especially dexamethasone (synthetic glucocorticoid), have a protective effect against oxidative stress induced by 3-nitropropionic acid in some brain regions of the Wistar rat.
Montilla
Pedro
P
Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Avda. Menéndez Pidal s/n, 14004 Cordoba, Spain. bb1molop@uco.es
Túnez
Isaac
I
Muñoz
M Carmen
MC
Salcedo
Manuel
M
Feijóo
Montserrat
M
Muñoz-Castañeda
Juan R
JR
Bujalance
Inmaculada
I
D000315:Adrenalectomy; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004396:Coloring Agents; D003345:Corticosterone / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D009574:Nitro Compounds; D010078:Oxazines; D018384:Oxidative Stress / Q000187:drug effects*; D011422:Propionates / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects*; D014966:Xanthenes
D004396:Coloring Agents; D005938:Glucocorticoids; D009574:Nitro Compounds; D010078:Oxazines; D011422:Propionates; D011506:Proteins; D014966:Xanthenes; C005843:resazurin; D003907:Dexamethasone; D013482:Superoxide Dismutase; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid; D003345:Corticosterone