title: Leiden mutation, bed rest and infection: simultaneous triggers for maternal deep-vein thrombosis and neonatal intracranial hemorrhage?
abstract: The possible etiologic roles of infection and bed rest are discussed in connection with a case of maternal homozygous Leiden mutation leading to prematurity, maternal deep-vein thrombosis and neonatal intracranial hemorrhage in a heterozygous premature baby. Maternal bacterial infection and bed rest may trigger deep-vein femoral thrombosis in women with a homozygous Leiden mutation on tocolytic therapy for the treatment of premature labor. The neonate carrying at least one mutated allele of factor V Leiden might be at risk for the development of intracranial hemorrhage.
authors.affiliation: Department of Obstetrics and Gynecology, University of Szeged, Faculty of Medicine, Albert Szent-Györgyi Medical and Pharmaceutical Center, Szeged, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Sikovanyecz
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Orvos
authors.forename: Attila
authors.initials: A
authors.lastname: Pál
authors.forename: Márta
authors.initials: M
authors.lastname: Katona
authors.forename: Emõke
authors.initials: E
authors.lastname: Endreffy
authors.forename: Emese
authors.initials: E
authors.lastname: Horváth
authors.forename: János
authors.initials: J
authors.lastname: Szabó
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000150:complications*; D001510:Bed Rest / Q000009:adverse effects*; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000235:genetics*; D005165:Factor V; D005260:Female; D005268:Femoral Vein; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy; D017354:Point Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology*; D011251:Pregnancy Complications, Infectious; D015149:Tocolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000209:etiology / Q000235:genetics*
chemical_list: D015149:Tocolytic Agents; C095381:factor V Leiden; D005165:Factor V