[The role of anti-dsDNA autoantibodies in the pathogenesis of atherosclerosis].
This paper presents involvement of autoimmune mechanism, and especially the role of autoantibodies anti-dsDNA (double stranded DNA) in atherosclerosis. Authors on the basis of results from experimental models and human studies demonstrate contribution of antibodies anti-DNA in the pathogenesis of atherosclerosis. Antibodies anti-dsDNA may play a role in atherosclerosis by promoting accumulation of cholesterol in macrophages and smooth muscle cells, influence on dyslipoproteinemias, cytotoxicity and releasing cytocines.
Mastej
Krzysztof
K
Katedra i Klinika Angiologii, Nadciśnienia, Tetniczego i Diabetologii Akademii Medycznej we Wrocławiu.
Adamiec
Rajmund
R
D001161:Arteriosclerosis / Q000209:etiology / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D004247:DNA / Q000276:immunology*; D006801:Humans
D001323:Autoantibodies; D004247:DNA