Proposed addendum to previously published fetal dose estimate tables for 18F-FDG.
Placental transfer and fetal dose estimates have been published for women in early pregnancy and at the end of each trimester for a large number of radiopharmaceuticals. For the case of (18)F-FDG, a dose was given with no information about placental transfer of the radiopharmaceutical. Recent publications have reported quantitative values for maternal and fetal uptake of (18)F-FDG in primates and new values for (18)F-FDG kinetics. In this article, these data are applied to give radiation dose estimates for the fetus at all stages of pregnancy for (18)F-FDG. The recommended values are 2.2 x 10(-2) mGy/MBq in early pregnancy, 2.2 x 10(-2) mGy/MBq at 3-mo gestation, 1.7 x 10(-2) mGy/MBq at 6-mo gestation, and 1.7 x 10(-2) mGy/MBq at 9-mo gestation.
Stabin
Michael G
MG
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA. michael.g.stabin@vanderbilt.edu
D001822:Body Burden; D005260:Female; D005333:Fetus / Q000000981:diagnostic imaging / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D008431:Maternal-Fetal Exchange; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010920:Placenta / Q000000981:diagnostic imaging / Q000378:metabolism*; D011247:Pregnancy; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods* / Q000592:standards; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000378:metabolism; D012062:Relative Biological Effectiveness
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18