[Role of insulin-like growth factor I in the development of diabetic retinopathy].
Diabetic retinopathy is one of the main causes of blindness. This review will discuss the role of IGF-I in the pathogenesis of diabetic retinopathy. IGF-I is a growth factor with a very wide spectrum of biological activities. It especially controls cell growth and metabolic processes. Disorders of IGF-I activity, which are observed during diabetes, contribute to pathologic vascularization of the eye, particularly in the retina. Reasons for this is local hypoxia, which results from chronic hyperglycaemia; damage of blood retina barrier and disorder of the axis IGF-I--growth hormone. In the first stage of diabetic retinopathy the deficit of the systemic IGF-I can also be of importance. The role of IGF-I in diabetic retinopathy enables better understanding, and thus in the future better intensive antidiabetic therapy in aspect of ophthalmic complications.
Gacka
Małgorzata
M
Katedra i Klinika Angiologii, Nadciśnienia, Tetniczego i Diabetologii, Akademii Medycznej we Wrocławiu.
Adamiec
Joanna
J
D003930:Diabetic Retinopathy / Q000209:etiology* / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D012171:Retinal Vessels / Q000503:physiopathology; D012307:Risk Factors
D007334:Insulin-Like Growth Factor I