title: Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.
abstract: Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.
authors.forename: Young-Il
authors.initials: YI
authors.lastname: Jo
authors.forename: Jae-Ho
authors.initials: JH
authors.lastname: Yoon
authors.forename: Sang-Youl
authors.initials: SY
authors.lastname: Shin
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Chang
authors.forename: Byung-Kook
authors.initials: BK
authors.lastname: Kim
authors.forename: Choon-Jo
authors.initials: CJ
authors.lastname: Jin
authors.forename: Jong-Oh
authors.initials: JO
authors.lastname: Song
mesh_terms: D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002408:Catheters, Indwelling / Q000382:microbiology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D010531:Peritoneal Dialysis, Continuous Ambulatory; D013203:Staphylococcal Infections / Q000188:drug therapy; D014640:Vancomycin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor; D014640:Vancomycin