title: The effect of anterior cruciate ligament surgery on bone mineral in the calcaneus: a prospective study with a 2-year follow-up evaluation.
abstract: OBJECTIVE
  The goal of this study was to evaluate the effect of anterior cruciate ligament (ACL) reconstruction on the bone mineral area mass (BMA) in the calcaneus on the injured and noninjured sides.
  
  
  METHODS
  A prospective cohort study with sequential assessments of bone mineral in the calcaneus before and after ACL reconstruction.
  
  
  METHODS
  Thirty-four consecutive patients with a unilateral ACL rupture underwent arthroscopic reconstruction using patellar tendon autografts. The BMA was assessed bilaterally in the calcaneus using a gamma camera according to the dual-energy photon absorptiometry technique, before surgery and after 6 and 26 months.
  
  
  RESULTS
  Thirty-one of 34 patients (20 men and 11 women) underwent all BMA measurements. The median age at index surgery was 27 (16 to 50) years, and the reconstruction was performed 12 (2 to 192) months after the injury. The median preoperative Tegner activity level increased from 3 (2 to 8) to 7 (2 to 9) at 26 months (P <.0001). The BMA in the calcaneus on both the injured and noninjured side decreased by 16% and 17% respectively from the preoperative measurement to the 26-month control (P =.0014; P =.0006). On all occasions, the BMA was lower on the injured side than on the noninjured side (P =.012).
  
  
  CONCLUSIONS
  Patients with a unilateral ACL rupture had a lower BMA in the calcaneus on the injured side compared with the noninjured side. Although patients increased activity levels after reconstruction, the BMA in the calcaneus decreased on both the injured and the noninjured side up to 2 years after surgery.
  
  
  METHODS
  Level II-1, prospective cohort study.
authors.affiliation: Department of Orthopaedics, Uddevalla Hospital, Uddevalla, Sweden. lars.ejerhed@vgregion.se
authors.forename: Lars
authors.initials: L
authors.lastname: Ejerhed
authors.forename: Jüri
authors.initials: J
authors.lastname: Kartus
authors.forename: Rolf
authors.initials: R
authors.lastname: Nilsén
authors.forename: Ulf
authors.initials: U
authors.lastname: Nilsson
authors.forename: Ragnar
authors.initials: R
authors.lastname: Kullenberg
authors.forename: Jon
authors.initials: J
authors.lastname: Karlsson
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D001182:Arthroscopy / Q000706:statistics & numerical data*; D002111:Calcaneus / Q000737:chemistry*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D007718:Knee Injuries / Q000150:complications / Q000534:rehabilitation; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000032:analysis*; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000706:statistics & numerical data*; D012421:Rupture / Q000601:surgery; D013710:Tendons / Q000637:transplantation; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D008903:Minerals