Amidations using N,N '-carbonyldiimidazole: remarkable rate enhancement by carbon dioxide.
Carbon dioxide catalyzes the reaction of imidazolides with amines to form amides. A substantial rate enhancement is observed in the presence of CO(2) compared to the CO(2)-free case. The scope and limitations of this reaction are discussed.
Vaidyanathan
Rajappa
R
Chemical Research and Development, Pfizer Inc., 0200-91-201, 7000 Portage Road, Kalamazoo, Michigan 49001, USA. rajappa.vaidyanathan@pfizer.com
Kalthod
Vikram G
VG
Ngo
Duc P
DP
Manley
Jerad M
JM
Lapekas
Sean P
SP