title: [Severe heart failure: treatment optimisation and monitoring using plasma NT-proBNP levels--an useful tool in clinical practice].
abstract: A young patient presented with a cardiomegaly of unknown origin. The cardiologic examination revealed a severe eccentric left ventricular hypertrophy and a dilatation of the other heart cavities as well as a strongly impaired global systolic function. The patient was treated with an ACE inhibitor, a diuretic and with a beta-blocking agent. The dosages of which were adapted accordingly to the plasma concentration of N-terminal-pro-brain-natriuretic peptide (NT-proBNP). After five months of treatment, a decrease of the NT-proBNP level to nearly normal values along with a significant reduction of the heart dimensions and a substantial improvement of left ventricular function were found.
authors.affiliation: Herzpraxis Birseck Arlesheim. contact@herzpraxisbirseck.ch
authors.forename: O
authors.initials: O
authors.lastname: Friesewinkel
authors.forename: M
authors.initials: M
authors.lastname: Furrer
authors.forename: G
authors.initials: G
authors.lastname: Hänggi
authors.forename: A
authors.initials: A
authors.lastname: Rutschmann
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use; D000077261:Carvedilol; D004232:Diuretics / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005080:Exercise Test / Q000187:drug effects; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007190:Indapamide / Q000627:therapeutic use*; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D020913:Perindopril / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use; D012016:Reference Values
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002227:Carbazoles; D004232:Diuretics; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D011412:Propanolamines; C109794:pro-brain natriuretic peptide (1-76); D000077261:Carvedilol; D020097:Natriuretic Peptide, Brain; D007190:Indapamide; D020913:Perindopril