title: Temporal properties of cerebellar-dependent memory consolidation.
abstract: Classical conditioning of the nictitating membrane response in rabbits is a well defined model of cerebellar-dependent motor memory. This memory undergoes a period of consolidation after the training session, when it is sensitive to reversible inactivations of the cerebellar cortex, but not of the cerebellar nuclei, with the GABA(A) receptor agonist muscimol. Here, the temporal properties of this cerebellar cortex-dependent consolidation were examined using delayed infusions of muscimol in cortical lobule HVI. Cortical infusions delayed by 5 or 45 min after a conditioning session produced significant and very similar impairments of consolidation, but infusions delayed by 90 min produced little or no impairment. Behavioral measures indicate that the muscimol infusions produced significant effects after approximately 30 min and they lasted for a few hours. So, over a time window beginning approximately 1 hr after the end of the training session and closing 1 hr after that, intracortical activity is critical for consolidation of this motor memory.
authors.affiliation: Division of Neurophysiology, The National Institute for Medical Research, London NW7 1AA, United Kingdom.
authors.forename: Samuel F
authors.initials: SF
authors.lastname: Cooke
authors.forename: Phillip J E
authors.initials: PJ
authors.lastname: Attwell
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Yeo
mesh_terms: D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002404:Catheterization; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003215:Conditioning, Eyelid / Q000187:drug effects / Q000502:physiology; D007263:Infusions, Parenteral; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009118:Muscimol / Q000493:pharmacokinetics / Q000494:pharmacology; D009541:Nictitating Membrane / Q000502:physiology; D011817:Rabbits; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors
chemical_list: D009118:Muscimol