Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries.
Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral L-arginine (4 weeks, 2 g, 3 times daily). L-arginine significantly improved angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma L-arginine, L-arginine:asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral L-arginine may represent a useful therapeutic option.
Palloshi
Altin
A
Division of Clinical Cardiology, Istituto Scientifico San Raffaele, Milan, Italy. altin_p@hotmail.com
Fragasso
Gabriele
G
Piatti
PierMarco
P
Monti
Lucilla D
LD
Setola
Emanuela
E
Valsecchi
Giampiero
G
Galluccio
Elena
E
Chierchia
Sergio L
SL
Margonato
Alberto
A
D000284:Administration, Oral; D000368:Aged; D001120:Arginine / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D017566:Microvascular Angina / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged
D001120:Arginine