title: Breast cancer prognosis in relation to family history of breast and ovarian cancer.
abstract: We linked four nationwide Swedish population-based registries to identify first-degree family history of breast and ovarian cancer among breast cancer cases diagnosed between 1991 and 1998 and followed them until death, emigration or end of follow-up in December 1998. The median follow-up was 36 months. Using Cox proportional hazards models, the hazard ratio of death (HR) due to breast cancer was estimated. Women with a family history of breast or ovarian cancer (n=2175, 12.7%) had a nonsignificantly better prognosis than women without any family history, HR 0.86 (95% CI 0.71-1.05); this appeared unrelated to age at diagnosis either in the index case or in relative(s) with breast and/or ovarian cancer. Our study shows that prognostic outlook is not worse among breast cancer patients with family history.
authors.affiliation: Department of Community Medicine and Behavioural Science (Biostatistics), Faculty of Medicine, Kuwait University, Box 24923, Safat 13110, Kuwait.
authors.forename: L
authors.initials: L
authors.lastname: Thalib
authors.forename: S
authors.initials: S
authors.lastname: Wedrén
authors.forename: F
authors.initials: F
authors.lastname: Granath
authors.forename: H-O
authors.initials: HO
authors.lastname: Adami
authors.forename: B
authors.initials: B
authors.lastname: Rydh
authors.forename: C
authors.initials: C
authors.lastname: Magnusson
authors.forename: P
authors.initials: P
authors.lastname: Hall
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000401:mortality*; D005192:Family Health; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000235:genetics; D011379:Prognosis; D012042:Registries