[Ticlopidine-induced acute cholestatic hepatitis. A case report].
A case of acute cholestatic hepatitis associated with use of antiplatelet agent ticlopidine is reported. Hepatitis developed 3 weeks after the beginning of the drug in a 72 year old man submitted to coronary angioplasty and stent implantation for unstable angina. The close time relationship between the administration of this antiplatelet drug and the acute onset of liver damage, the exclusion of other hepatobiliary disease and the progressive normalisation of biochemical parameters following withdrawal of the drug strongly suggest that ticlopidine was involved in the pathogenesis of this syndrome.
Gandolfi
Alberto
A
Divisione di Medicina Interna, Ospedale San Sebastiano, Correggio, ASL di Reggio Emilia.
Mengoli
Marco
M
Rota
Edda
E
Tolomelli
Stefano
S
Zanghieri
Gianni
G
Bernini
Maria Vilma
MV
Lusetti
Luciano
L
D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects*
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine