Catalytic regiodivergent kinetic resolution of allylic epoxides: a new entry to allylic and homoallylic alcohols with high optical purity.
A novel regiodivergent kinetic resolution of a series of allylic epoxides with alkylzinc reagents is described. Results demonstrate the potential of chiral copper-phosphoramidite catalysts for enantiomer differentiation of allylic epoxides, allowing a chiral catalyst-stereoregulated synthesis of cyclic allylic and homoallylic alcohols with high optical purities.
Pineschi
Mauro
M
Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Via Bonanno 33, 56126 Pisa, Italy. pineschi@farm.unipi.it
Del Moro
Federica
F
Crotti
Paolo
P
Di Bussolo
Valeria
V
Macchia
Franco
F