title: Isolated monolateral neurosensory hearing loss as a rare sign of neuroborreliosis.
abstract: Lyme disease, or borreliosis, is a zoonosis transmitted by Borrelia burgdorferi which also involves the central nervous system (CNS), in 15% of affected individuals, with the occurrence of aseptic meningitis, fluctuating meningoencephalitis, or neuropathy of cranial and peripheral nerves. Encephalopathy with white matter lesions revealed by magnetic resonance imaging (MRI) scans in late, persistent stages of Lyme disease has been described. In this report, we describe a patient with few clinical manifestations involving exclusively the eighth cranial nerve, monolaterally and diffuse bilateral alterations of the white matter, particularly in the subcortical periventricular regions at cerebral MRI. This single patient study shows that the search for antibodies against Borrelia burgdoferi should always be performed when we face a leukoencephalopathy of unknown origin. An isolated lesion of the eighth cranial nerve can be the only neurologic sign in patients with leukoencephalopathy complicating Lyme disease.
authors.affiliation: Department of Neurology, Oasi Institute for Research on Mental Retardation and Brain Aging, Via Conte Ruggero 73, I-94018 Troina (EN), Italy. ivaniero@oasi.en.it
authors.forename: I
authors.initials: I
authors.lastname: Iero
authors.forename: M
authors.initials: M
authors.lastname: Elia
authors.forename: F I I
authors.initials: FI
authors.lastname: Cosentino
authors.forename: B
authors.initials: B
authors.lastname: Lanuzza
authors.forename: R S
authors.initials: RS
authors.lastname: Spada
authors.forename: G
authors.initials: G
authors.lastname: Toscano
authors.forename: M
authors.initials: M
authors.lastname: Tripodi
authors.forename: A
authors.initials: A
authors.lastname: Belfiore
authors.forename: R
authors.initials: R
authors.lastname: Ferri
mesh_terms: D000328:Adult; D001898:Borrelia / Q000276:immunology / Q000302:isolation & purification; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007839:Functional Laterality; D034381:Hearing Loss / Q000382:microbiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D020852:Lyme Neuroborreliosis / Q000150:complications* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000473:pathology; D011859:Radiography; D000160:Vestibulocochlear Nerve Diseases / Q000382:microbiology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M