[Prevention of cortisone-induced osteoporosis].
Osteoporosis and fractures are the frequent consequences of glucocorticoid therapy. Cancellous bone is primarily affected with a decrease of bone formation and an increase of bone resorption. Prevention of corticosteroid-induced osteoporosis is based upon general measures such as calcium and vitamine D supplementation, adequate protein intake, regular physical exercise, and upon specific therapies like those used in primary osteoporosis. Bisphosphonates which are potent bone resorption inhibitors have been shown to reduce bone mineral density and to decrease vertebral fracture rate. Therefore, they appear to be a first choice in the prevention of corticosteroid-induced osteoporosis.
Trombetti
A
A
Service des Maladies Osseuses (Centre collaborateur de l'OMS pour la Prévention de l'Ostéoporose), Département de Réhabilitation et Gériatrie, Hôpitaux Universitaires de Genève.
Ferrari
S
S
Stoermann-Chopard
C
C
Rizzoli
R
R
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects*; D003348:Cortisone / Q000009:adverse effects* / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005598:Fractures, Spontaneous / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans; D008134:Long-Term Care; D010010:Osteoclasts / Q000187:drug effects; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control*; D012307:Risk Factors
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D003348:Cortisone