title: Dengue: defining protective versus pathologic immunity.
abstract: Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.
authors.affiliation: Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. alan.rothman@umassmed.edu
authors.forename: Alan L
authors.initials: AL
authors.lastname: Rothman
mesh_terms: D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000276:immunology*; D014612:Vaccines / Q000276:immunology
chemical_list: D014612:Vaccines