Mitomycin does not prevent laryngotracheal repeat stenosis after endoscopic dilation surgery: an animal study.
OBJECTIVE
Conflicting data exist in the literature regarding the role of mitomycin in the prevention and treatment of laryngotracheal stenosis. The purpose of the study was to assess the value of mitomycin in preventing repeat stenosis after endoscopic dilation surgery of well-established stenoses.


METHODS
Prospective controlled animal study.


METHODS
Laryngotracheal stenosis was induced in 16 dogs. After a period of 3 months the dogs underwent endoscopic dilation and were randomly divided into two groups. The control group received immediate topical application of normal saline. Dogs in the mitomycin group received immediate topical application of 0.5 mg mitomycin. The animals were then observed for 3 more months before euthanasia. The laryngeal lumens were measured endoscopically at baseline, before dilation, and before euthanasia. A comparison was made between the two study groups by means of the Wilcoxon rank-sum test for change in the percentage of stenosis attained by the endoscopic dilation.


RESULTS
Nine dogs were included in the control group, and seven in the mitomycin group. Group comparison for initial occlusion before endoscopic dilation using Wilcoxon rank-sum test showed no difference between the two groups (z = 0.16 [P =.87]). Three months after endoscopic dilation, no difference was observed between the two groups regarding the change in the percentage of occlusion (z = -0.21 [P =.83]).


CONCLUSIONS
Mitomycin exerts a benefit equal to that of normal saline when applied to a well-established laryngotracheal stenosis in dogs and does not prevent repeat stenosis after endoscopic dilation surgery.
Eliashar
Ron
R
Department of Otolaryngology-Head and Neck Surgery, Hadassah Medical Center, The Hebrew University School of Medicine, Jerusalem, Israel. ron.eliashar.com
Gross
Menachem
M
Maly
Bella
B
Sichel
Jean-Yves
JY
D000477:Alkylating Agents / Q000627:therapeutic use*; D000818:Animals; D004106:Dilatation / Q000295:instrumentation*; D004285:Dogs; D007828:Laryngoscopy / Q000379:methods*; D007829:Laryngostenosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D016685:Mitomycin / Q000627:therapeutic use*; D011897:Random Allocation; D055502:Secondary Prevention; D014135:Tracheal Stenosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery
D000477:Alkylating Agents; D016685:Mitomycin