title: The Coapsys device to treat functional mitral regurgitation: in vivo long-term canine study.
abstract: OBJECTIVE
  We evaluated the capability of the Myocor Coapsys device (Myocor, Inc, Maple Grove, Minn) to reduce functional mitral regurgitation in a canine model of dilated cardiomyopathy.
  
  
  METHODS
  Functional mitral regurgitation with heart failure was induced in 7 dogs by rapid ventricular pacing. The Coapsys device, which consists of anterior and posterior epicardial pads connected by a subvalvular chord, was then implanted. Heart failure was maintained by continued pacing for 8 weeks. Hemodynamic and echocardiographic measurements were performed at pre- and postsizing and after 8 weeks. The Coapsys subvalvular chord was cut to verify that maintenance of valve competency was due to the device.
  
  
  RESULTS
  All implants were performed off-pump without atriotomy. Mitral regurgitation was reduced in all animals; mean mitral regurgitation grade was reduced from 2.9 +/- 0.7 to 0.7 +/- 0.8 (P =.00005) and was maintained at 0.8 +/- 0.8 after 8 weeks, without hemodynamic compromise or structural damage to the mitral valve. Mitral regurgitation returned to 3.6 +/- 0.8 (P =.102 versus presizing) after cutting the Coapsys subvalvular chord.
  
  
  CONCLUSIONS
  The Coapsys device consistently and chronically reduced functional mitral regurgitation. This device is in clinical trials in the United States.
authors.affiliation: Department of Bioengineering, The Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Inoue
authors.forename: Patrick M
authors.initials: PM
authors.lastname: McCarthy
authors.forename: Zoran B
authors.initials: ZB
authors.lastname: Popović
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Doi
authors.forename: Soren
authors.initials: S
authors.lastname: Schenk
authors.forename: Hassan
authors.initials: H
authors.lastname: Nemeh
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ootaki
authors.forename: Michael W
authors.initials: MW
authors.lastname: Kopcak
authors.forename: Raymond
authors.initials: R
authors.lastname: Dessoffy
authors.forename: James D
authors.initials: JD
authors.lastname: Thomas
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
mesh_terms: D000818:Animals; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery; D003971:Diastole / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D004452:Echocardiography; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006353:Heart-Assist Devices; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D008955:Models, Cardiovascular; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D013995:Time; D016896:Treatment Outcome; D014262:Tricuspid Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery