title: Impact of flow level on coronary flow velocity pattern. A doppler flow study in patients with first acute myocardial infarction.
abstract: Analysis of coronary flow velocity pattern has been used to assess microvascular function post acute myocardial infarction (AMI). This study sought to analyze whether the flow level has an impact on parameters of coronary flow velocity pattern. Parameters of coronary flow velocity pattern were determined at baseline and during increased flow due to maximal hyperemia induced by adenosine in 25 patients after PTCA for first AMI using Doppler flow wires. Patients were divided into those with depressed (global wall motion index (GWMI) > or = 1.5; n = 14) and those with preserved (GWMI < 1.5; n = 11) left ventricular (LV) function at 4 weeks. Coronary flow velocity pattern at rest was different between patients with depressed and patients with preserved LV function at follow-up. A difference in flow pattern between the groups remained at increased flow level. However, increase of flow altered parameters of flow pattern. Diastolic deceleration rate (DSR) increased for patients with preserved LV function (53.7+/-25.6 at baseline vs. 67.0+/-29.8 cm/s2 with adenosine) and depressed LV function (95.3+/-58.6 vs. 110.7+/-61.4 cm/s2, respectively, p = 0.0012). Induction of hyperemia resulted also in increased systolic and diastolic peak flow velocity and diastolic deceleration time (DDT). Higher flow had no impact on early systolic retrograde flow, systolic flow duration and diastolic-systolic velocity ratio (DSVR). The coronary flow velocity pattern allows prediction of LV function at 4 weeks after AMI. However, it should be considered that some parameters of the flow velocity pattern are affected by the coronary flow level.
authors.affiliation: Medical Clinic I, University Hospital RWTH Aachen, Germany. rhoffmann@ukaachen.de
authors.forename: Rainer
authors.initials: R
authors.lastname: Hoffmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lepper
authors.forename: Nicole
authors.initials: N
authors.lastname: Heussen
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elkelini
authors.forename: Gertjan Tj
authors.initials: GT
authors.lastname: Sieswerda
authors.forename: Otto
authors.initials: O
authors.lastname: Kamp
authors.forename: Carel C
authors.initials: CC
authors.lastname: de Cock
authors.forename: Paolo
authors.initials: P
authors.lastname: Voci
authors.forename: Cees A
authors.initials: CA
authors.lastname: Visser
authors.forename: Peter
authors.initials: P
authors.lastname: Hanrath
mesh_terms: D000208:Acute Disease; D000241:Adenosine / Q000008:administration & dosage; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity / Q000502:physiology; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003287:Contrast Media / Q000008:administration & dosage; D003326:Coronary Circulation / Q000502:physiology*; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D005466:Fluorocarbons; D005500:Follow-Up Studies; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D015425:Myocardial Reperfusion / Q000379:methods; D015607:Stents; D014665:Vasodilator Agents / Q000008:administration & dosage; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D014665:Vasodilator Agents; D000241:Adenosine; C108042:perfluorobutane