Biosynthetic studies of the DSP toxin skeleton.
Marine toxins have drawn wide interest because their economical impact and disastrous effect upon the shellfish industry and public health in many parts of the world. One of the most interesting group of substances of marine toxins, from structural and pharmacological points of view are polyether compounds, which generally present a great diversity in size and potent biological activities. The subject of this work was about to biosynthesis of okadaic acid skeleton as leader as DSP toxins. Its biosynthesis attracts considerable attention since the carbon skeleton has been shown to be synthesised via an unusual route. In this paper we report on stable isotope incorporation experiments on DSP toxin in artificial cultures of dinoflagellate. The comparison of the degrees of incorporation in these samples measured by different methods led to contradictory results. This implies that further experimental data is needed in order to propose a logical biogenetic scheme.
Daranas
Antonio H
AH
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.
Fernández
José J
JJ
Norte
Manuel
M
Gavín
José A
JA
Suárez-Gómez
Blanca
B
Souto
María L
ML
D000818:Animals; D002247:Carbon Isotopes; D003903:Deuterium; D004141:Dinoflagellida / Q000378:metabolism; D008387:Marine Toxins / Q000096:biosynthesis* / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D019319:Okadaic Acid / Q000737:chemistry / Q000378:metabolism
D002247:Carbon Isotopes; D008387:Marine Toxins; D019319:Okadaic Acid; D003903:Deuterium