Albendazole versus metronidazole treatment of adult giardiasis: An open randomized clinical study.
OBJECTIVE
To investigate the efficacy and tolerability of albendazole and metranidazole treatment in giardiasis.


METHODS
The open comparative randomized trial was carried out prospectively from December 1999 to July 2001 in Duzce City of Turkey. The diagnosis was based on the presence of signs and symptoms compatible with giardiasis including a positive stool examination of giardia cysts or trophozoite. Metranidazole group consisted of 29 patients and was given metranidazole 500 mg, three times a day for 5 d and albendazole group was consisted of 28 patients and was given albendazole 400 mg/d for 5 d.


RESULTS
There were no significant differences in demographical and therapeutical effects and patient's compliance between both groups. But side effects were seen more in metranidazole group than in albendazole group.


CONCLUSIONS
Albendazole is as effective as metranidazole in adults' giardiasis. Albendazole has less side effect potentials than metranidazole in the treatment of giardiasis.
Karabay
Oguz
O
Izzet Baysal Medical Faculty Infectious Disease Unit. Golkoy Kampusu/Bolu /Turkey. drkarabay@yahoo.com
Tamer
Ali
A
Gunduz
Huseyin
H
Kayas
Derya
D
Arinc
Huseyin
H
Celebi
Harika
H
D000328:Adult; D015766:Albendazole / Q000008:administration & dosage*; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D000994:Antitrichomonal Agents / Q000008:administration & dosage*; D005260:Female; D005873:Giardiasis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
D000981:Antiprotozoal Agents; D000994:Antitrichomonal Agents; D008795:Metronidazole; D015766:Albendazole