Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men.
OBJECTIVE
To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome.


METHODS
Prospective, clinical study.


METHODS
University hospital.


METHODS
Ten normal healthy men.


METHODS
Gonadotropin-releasing hormone (GnRH) agonist, 3.75 mg, administered monthly for 3 months.


METHODS
Insulin action (M/I ratio).


RESULTS
The M/I ratio decreased from 0.24 +/- 0.04 to 0.17 +/- 0.04 after GnRH agonist therapy.


CONCLUSIONS
In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.
Chauhan
Subodhsingh
S
Division of Reproductive Endocrine and Infertility, Department of Obstetrics and Gynecology, Wayne State University /Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA.
Collins
Karen
K
Kruger
Michael
M
Diamond
Michael P
MP
D000328:Adult; D015309:Glucose Clamp Technique; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007329:Insulin Antagonists / Q000494:pharmacology*; D016729:Leuprolide / Q000494:pharmacology*; D008297:Male; D012016:Reference Values; D013739:Testosterone / Q000037:antagonists & inhibitors
D007328:Insulin; D007329:Insulin Antagonists; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D016729:Leuprolide