title: Effect of modified ultrafiltration on inflammatory mediators, coagulation factors, and other proteins in blood after an extracorporeal circuit.
abstract: Modified ultrafiltration (MUF) is a technique able to remove the excess body fluid and inflammatory mediators associated with the use of a cardiopulmonary bypass (CPB). It has been shown to reduce morbidity after cardiac operations in children. Application of MUF after adult cardiac operations has also been suggested being associated with a lower prevalence of early morbidity. However, the relationship between the concentration of mediators in the blood and postoperative morbidity remains yet to be proved. In this study, changes of various chemical mediators in the filtrate and blood before and after MUF have been evaluated in adult patients. Significant reductions of blood levels of inflammatory cytokines were not observed after MUF. On the other hand, MUF significantly elevated hematocrit, number of red cells, concentrations of albumine, coagulation Factor VII and X, platelet factor (PF)-4, and antithrombin (AT-) III.
authors.affiliation: Department of Surgery II, Research Institute, National Defense Medical College, Saitama, Japan. BXB01424@nifty.ne.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujita
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishihara
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kusama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Shimizu
authors.forename: Tamizo
authors.initials: T
authors.lastname: Kimura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Iizuka
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Ozaki
authors.forename: Masato
authors.initials: M
authors.lastname: Muraoka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Shigeto
authors.initials: S
authors.lastname: Takeshima
authors.forename: Makoto
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Maehara
mesh_terms: D001773:Blood Cells / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000032:analysis*; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002318:Cardiovascular Diseases / Q000601:surgery; D013504:Cardiovascular Surgical Procedures / Q000379:methods; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D014462:Ultrafiltration / Q000379:methods*
chemical_list: D001779:Blood Coagulation Factors; D018836:Inflammation Mediators