title: [The effect of platelet-rich plasma on new bone formation by augmentation with osseoconductive bone substitute material in beagle dogs].
abstract: Animal experiments were carried out with osseoconductive bone substitute beta-tricalcium phosphate (beta-TCP), with the aim of assessing the effect of the growth factors synthesized by platelets on the speed of beta-TCP incorporation and on the quality of newly formed bone. The question arises whether the results attained with this synthetic material approach are comparable to those attained with autologous bone. Defects in the mandibles of beagle dogs were filled with beta-TCP or with the mixture of beta-TCP and platelet rich plasma (PRP) obtained from autologous blood. The quality of the newly formed bone and the effect of PRP were studied by histologic and histomorphometric methods. On the 6th week, bone formation seemed to be more effective when PRP was applied in comparison with beta-TCP alone, but the difference was not significant. On the 12th week bone formation was significantly greater. The results demonstrate that the use of PRP accelerates the remodelling of the synthetic bone-substitute material beta-TCP.
authors.affiliation: Semmelweis Egyetem, Fogorvostudományi Kar, Szájsebészeti és Fogászati Klinika.
authors.forename: Norbert
authors.initials: N
authors.lastname: Velich
authors.forename: Katalin
authors.initials: K
authors.lastname: Kovács
authors.forename: Tamás
authors.initials: T
authors.lastname: Huszár
authors.forename: Gábor
authors.initials: G
authors.lastname: Semjén
authors.forename: Jenó
authors.initials: J
authors.lastname: Reiczigel
authors.forename: György
authors.initials: G
authors.lastname: Szabó
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Suba
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001792:Blood Platelets; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000494:pharmacology; D004285:Dogs; D008334:Mandible; D016348:Osseointegration; D010012:Osteogenesis; D010949:Plasma
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; C018392:tricalcium phosphate