title: Nonlinear photodynamic therapy. Photochemical dose levelling within a tumor by saturating a photosensitizer's triplet states.
abstract: The photodynamic therapy involving saturation of triplet state of a photosensitizer by short high-energy light pulses was studied theoretically. The possibility of creating a uniform therapeutic dose distribution throughout a large tumor using both surface and interstitial irradiation is shown. Possible thickness of the treated tissue layer and the required duration of the PDT session are estimated.
authors.affiliation: State Research Center of the Russian Federation, Research Institute of Organic Intermediates and Dyes, 1 ul. B. Sadovaya, 123995 Moscow, Russian Federation. kogan@dic.ru
authors.forename: Boris Ya
authors.initials: BY
authors.lastname: Kogan
mesh_terms: D007700:Kinetics; D008962:Models, Theoretical; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D011879:Radiotherapy Dosage; D014018:Tissue Distribution
chemical_list: D017319:Photosensitizing Agents