title: Inhibition of neutrophil activity in cardiac surgery with cardiopulmonary bypass: a novel strategy with the leukocyte inhibition module.
abstract: Recently, we showed that the arterial in-line application of the leukocyte inhibition module (LIM) within the heart-lung machine limits overshooting leukocyte activity and cardiac tissue damage. Moreover, significantly better cardiac function was found in an experimental animal model when LIM was used. In the meantime, the first promising clinical data exist. LIM has to be regarded as an essential tool in extracorporeal circulation, in the future, to improve postoperative clinical outcome and to reduce costs. This review summarizes the biological background of LIM and the current experience obtained in experimental models and clinical studies.
authors.affiliation: Department of Vascular Surgery, Medical Faculty of Marília (FAMEMA), Sao Paulo, Brazil.
authors.forename: José Bitu
authors.initials: JB
authors.lastname: Moreno
authors.forename: Stefan
authors.initials: S
authors.lastname: Margraf
authors.forename: Alina M
authors.initials: AM
authors.lastname: Schuller
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: A
authors.initials: A
authors.lastname: Moritz
authors.forename: M
authors.initials: M
authors.lastname: Scholz
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D020099:Coated Materials, Biocompatible; D005112:Extracorporeal Circulation; D005374:Filtration / Q000295:instrumentation; D006801:Humans; D007937:Leukapheresis / Q000295:instrumentation*; D007962:Leukocytes; D018375:Neutrophil Activation / Q000187:drug effects; D019014:fas Receptor / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D020099:Coated Materials, Biocompatible; D019014:fas Receptor