Preparation and chiral recognition of a novel chiral stationary phase for high-performance liquid chromatography, based on mono(6A-N-allylamino-6A-deoxy)-perfunctionalized beta-cyclodextrin and covalently bonded silica gel.
A novel chiral stationary phase (CSP) was prepared by immobilizing mono(6A-N-allylamino-6A-deoxy)-perphenylcarbamoylated beta-cyclodextrin onto the surface of silica gel via hydrosilylation. The chromatographic properties of this column were tested with a wide range of structurally diverse racemic compounds and drugs under reverse phases. Separation mechanisms involved are also discussed.
Lai
Xiang-Hua
XH
Department of Chemistry, National University of Singapore, Singapore 119260, Singapore.
Ng
Siu-Choon
SC
D000319:Adrenergic beta-Antagonists / Q000737:chemistry / Q000302:isolation & purification; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification; D011743:Pyrimidines / Q000737:chemistry / Q000302:isolation & purification; D058428:Silica Gel; D012822:Silicon Dioxide / Q000737:chemistry*; D013237:Stereoisomerism; D014508:Urea / Q000737:chemistry
D000319:Adrenergic beta-Antagonists; D001592:Benzyl Alcohols; D003505:Cyclodextrins; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D011743:Pyrimidines; C491657:mono(6A-N-allylamino-6A-deoxy)-perphenylcarbamoylated beta-cyclodextrin; D058428:Silica Gel; D012822:Silicon Dioxide; D014508:Urea