title: Replacement and refinement of animal experimentation in drug research has been and will be a permanent and necessary process.
authors.affiliation: Department of Experimental and Clinical Pharmacology and Toxicology, Erlangen, Germany.
authors.forename: Kay
authors.initials: K
authors.lastname: Brune
mesh_terms: D032761:Animal Experimentation / Q000266:history / Q000592:standards*; D000818:Animals; D049671:History, 18th Century; D004364:Pharmaceutical Preparations; D012106:Research / Q000266:history / Q000592:standards / Q000639:trends*
chemical_list: D004364:Pharmaceutical Preparations