title: Dynamic NMR spectroscopy of hyperpolarized (129)Xe in human brain analyzed by an uptake model.
abstract: Hyperpolarized (129)Xe (HpXe) NMR not only holds promise for functional lung imaging, but for measurements of tissue perfusion as well. To investigate human brain perfusion, several time-series of (129)Xe MR spectra were recorded from one healthy volunteer after HpXe inhalation. The time-dependent amplitudes of the MR spectra were analyzed by using a compartment model for xenon uptake modified to account for the loss of (129)Xe polarization due to RF-excitation and for the breathhold technique used in the experiments. This analysis suggests that the resonances detected at 196.5 +/- 1 ppm and 193 +/- 1 ppm originate from HpXe dissolved in gray and white matter, respectively, and that T(1) relaxation times of HpXe are different in gray and white matter (T(1g) > T(1w)).
authors.affiliation: Physikalisch-Technische Bundesanstalt, Berlin, Germany. wolfgang.kilian@ptb.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kilian
authors.forename: Frank
authors.initials: F
authors.lastname: Seifert
authors.forename: Herbert
authors.initials: H
authors.lastname: Rinneberg
mesh_terms: D000465:Algorithms; D001921:Brain / Q000378:metabolism*; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008954:Models, Biological; D016011:Normal Distribution; D013997:Time Factors; D014018:Tissue Distribution; D014978:Xenon / Q000493:pharmacokinetics; D014979:Xenon Isotopes
chemical_list: D014979:Xenon Isotopes; D014978:Xenon