Duration of antiinflammatory and symptomatic effects after suspension of intranasal corticosteroid in persistent allergic rhinitis.
BACKGROUND
Allergic rhinitis is characterized by an inflammatory response consequent to allergen exposure. Intranasal corticosteroids represent a first line treatment, but there is no adequate knowledge concerning the duration of symptomatic and antiinflammatory effects after their suspension. Thus, we aimed at investigating this issue.


METHODS
Twelve children with persistent allergic rhinitis were treated with FPANS for 30 days and were followed for 12 days after its suspension. Nasal symptoms, considered as TSS, and inflammatory cells, recovered by nasal scraping, were evaluated.


RESULTS
FPANS significantly reduced TSS (p<0.0001), neutrophils (p<0.001), and eosinophils (p<0.0001) after 4 days of treatment. Symptoms and cellular infiltrate quickly reappeared after suspension (respectively after 3 days for symptoms (p<0.05), after 4 days for neutrophils (p<0.05), and 6 days for eosinophils (p<0.001).


CONCLUSIONS
These findings suggest that nasal corticosteroid treatment is highly effective in nasal symptoms' relief and inflammation's control, but its suspension induces a rapid reappearance of them.
Ciprandi
Giorgio
G
Allergy, Dpt Head-Neck, San Martino Hospital.
Ricca
Vittorio
V
Paola
Ferrero
F
Alessandra
Bairo
B
Riccio
Anna Maria
AM
Milanese
Manlio
M
Frati
F
F
Tosca
Maria Angela
MA
D000281:Administration, Intranasal; D000293:Adolescent; D000730:Androstadienes / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D004334:Drug Administration Schedule; D004804:Eosinophils / Q000473:pathology; D005260:Female; D000068298:Fluticasone; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008925:Mites; D009297:Nasal Mucosa / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D012008:Recurrence; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D013997:Time Factors
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone