title: cis-Cyclopentyl PNA (cpPNA) as constrained chiral PNA analogues: stereochemical dependence of DNA/RNA hybridization.
abstract: DNA/RNA hybridization studies of PNA-T oligomers with cis-(1S,2R/1R,2S)-cyclopentyl units in the backbone show stereochemistry dependent binding with RNA/DNA discrimination.
authors.affiliation: Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune, 411008, India.
authors.forename: T
authors.initials: T
authors.lastname: Govindaraju
authors.forename: Vaijayanti A
authors.initials: VA
authors.lastname: Kumar
authors.forename: Krishna N
authors.initials: KN
authors.lastname: Ganesh
mesh_terms: D001665:Binding Sites; D018360:Crystallography, X-Ray; D003517:Cyclopentanes / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003517:Cyclopentanes; D003521:Cyclopropanes; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA