title: Treatment with anticoagulants in cerebral events (TRACE).
abstract: 90 patients with acute stroke and a concomitant cardiac embolism source or a symptomatic high-grade stenosis of an extra-or intracranial vessel received in a mulitcenter, randomized, controlled study either Enoxaparin 1 mg/kg BW s.c. b.i.d. or i.v. heparin aPTT-adjusted daily for 8 +/- 2 days as secondary prophylaxis. There were no significant differences between the two groups regarding cerebral and systemic embolic events, bleeding complications, length of hospital stay, number of diagnostic and therapeutic measures and outcome after three months. This suggests that Enoxaparin, which is easier to administer and monitor, is a safe drug in patients with acute cerebral events.
authors.affiliation: Department of Neurology and Intensive Stroke Unit, Westpfalz-Klinikum GmbH, 67655 Kaiserslautern, Germany.
authors.forename: Ralph
authors.initials: R
authors.lastname: Woessner
authors.forename: Markus
authors.initials: M
authors.lastname: Grauer
authors.forename: Oliver
authors.initials: O
authors.lastname: Bianchi
authors.forename: Martin
authors.initials: M
authors.lastname: Mueller
authors.forename: Stefan
authors.initials: S
authors.lastname: Moersdorf
authors.forename: Peter
authors.initials: P
authors.lastname: Berlit
authors.forename: Michael
authors.initials: M
authors.lastname: Goertler
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Grotemeyer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Sliwka
authors.forename: Martin
authors.initials: M
authors.lastname: Stoll
authors.forename: Johannes
authors.initials: J
authors.lastname: Treib
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects; D003251:Constriction, Pathologic; D016903:Drug Monitoring; D004617:Embolism; D017984:Enoxaparin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006470:Hemorrhage; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006493:Heparin