title: Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women.
abstract: Elevated serum total homocysteine (tHcy) levels are associated with increased risk for cardiovascular disease and dementia. The prevalence rates of homozygous mutants among Japanese women (n = 300) were 17.3%, 1.3%, 18.6%, and 5.3% for methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, reduced folate carrier (RFC-1) A80G, and methionine synthase (MS) A2756G, respectively. The tHcy value was significantly lower (p < 0.001) in young women with CC or CT of MTHFR than with TT (10.9+/-4.7 micromol/L) (n =250). Diversities of serum folate and tHcy in women with 23 combinations of different alleles at low folate intake converged to the highest (34.0+/-8.6 nmol/L) and lowest (7.6+/-1.5 micromol/L) levels, respectively, after folic acid (400 microg/day) supplementation. In the regression equation ( y= ax + b) of serum folate ( y nmol/L) plotted against mean folate intake ( x microg/day), the values of "a" were 0.032, 0.037, and 0.045 for individuals with CC, CT, and TT alleles, respectively, of MTHFR.
authors.affiliation: Department of Medical Chemistry, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado-shi, Saitama 350-0288, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Kumiko
authors.initials: K
authors.lastname: Kato
authors.forename: Yoko
authors.initials: Y
authors.lastname: Saito
authors.forename: Kazuto
authors.initials: K
authors.lastname: Yasuda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kagawa
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005820:Genetic Testing; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D016387:Women's Health
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)