[Diagnosis and treatment for adrenocortical carcinoma].
Adrenocortical carcinomas frequently hypersecrete multiple adrenocortical steroids and their precursors. CT scan and MRI usually demonstrate necrotic lesions or areas of calcification in this uncommon tumor. Therapy in patients with adrenocortical carcinoma is less satisfactory. Surgical excision is the primary mode of therapy. Up to the present, mitotane (o, p'-DDD) treatment combined with chemotherapy has been the only palliative measure for patients with nonresectable or extensively recurrent tumors.
Iihara
Masatoshi
M
Dept. of Endocrine Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan.
Obara
Takao
T
D000302:Adrenal Cortex / Q000000981:diagnostic imaging; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002784:Cholesterol; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D008939:Mitotane / Q000008:administration & dosage; D011379:Prognosis; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed
D018931:Antineoplastic Agents, Hormonal; D007457:Iodine Radioisotopes; D005047:Etoposide; D008939:Mitotane; D004317:Doxorubicin; D002784:Cholesterol; D002945:Cisplatin