title: 3D DT-MRI using a reduced-FOV approach and saturation pulses.
abstract: Diffusion tensor imaging (DTI) can provide vital insights into brain connectivity, and may become an important tool for the diagnosis and treatment of neurological disease. However, DTI's intrinsic low signal-to-noise ratio (SNR) and vulnerability to ghosting artifacts can result in poor image quality with low spatial resolution, which limits its clinical applications. In this study, a new double-shot EPI sequence (half-FOV EPI) with high spatial resolution was developed. This method enables DT measurements to be obtained with high isotropic spatial resolution and whole-brain coverage. To avoid ghosting artifacts, the data are combined in image space rather than in k-space.
authors.affiliation: School of Medical Technology, ChangGung University, TaoYuan County, Taiwan. jwang@mail.cgu.edu.tw
authors.forename: Jiun-Jie
authors.initials: JJ
authors.lastname: Wang
authors.forename: Ralf
authors.initials: R
authors.lastname: Deichmann
authors.forename: Robert
authors.initials: R
authors.lastname: Turner
authors.forename: Roger
authors.initials: R
authors.lastname: Ordidge
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D019047:Phantoms, Imaging