Ketene acetal and spiroacetal constituents of the marine fungus Aigialus parvus BCC 5311.
Aigialone (1) and aigialospirol (2), two structurally unique compounds, were isolated from the mangrove fungus Aigialus parvus BCC 5311. The structure of the new ketene acetal 1 was elucidated by spectral analysis, and its relative stereochemistry was determined by X-ray crystallography. The stereochemistry of aigialospirol (2), elucidated by NMR spectral analysis, suggested that this compound is possibly derived from hypothemycin (3), a metabolite previously isolated from this same fungus.
Vongvilai
Pornrapee
P
Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
Isaka
Masahiko
M
Kittakoop
Prasat
P
Srikitikulchai
Prasert
P
Kongsaeree
Palangpon
P
Thebtaranonth
Yodhathai
Y
D000080:Acetals / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005030:Ethylenes; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013785:Thailand; D015025:Zearalenone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology
D000080:Acetals; D001572:Benzofurans; D005030:Ethylenes; D007659:Ketones; C484838:aigialone; C484839:aigialospirol; C120440:hypothemycin; D015025:Zearalenone; C008223:ketene