How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications.
We have synthesized a modified 6-mer using Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications as a template. We have replaced from one to all four 2'-deoxyguanosines by 8-aza-3-deaza-2'-deoxyguanosine (c3z8dG, 1) in order to investigate the anti-HIV structure activity relationship (SAR). ODN 4 (TGGG*AG) is the only one that exhibits a moderate anti-HIV-1 activity.
Jaksa
Suzana
S
National Institute of Chemistry, Ljubljana, Slovenia.
Kralj
Bogdan
B
Pannecouque
Christophe
C
Balzarini
Jan
J
De Clercq
Erik
E
Kobe
Joze
J
D019380:Anti-HIV Agents / Q000494:pharmacology; D002942:Circular Dichroism; D004247:DNA / Q000187:drug effects*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D013058:Mass Spectrometry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000494:pharmacology*
D019380:Anti-HIV Agents; D009838:Oligodeoxyribonucleotides; D004247:DNA; D003849:Deoxyguanosine