title: Metaplastic mammary carcinoma with osteoclast-like giant cells: identical point mutation of p53 gene only identified in both the intraductal and sarcomatous components.
abstract: Metaplastic mammary carcinoma with osteoclast-like giant cells is a rare neoplasm, and the histogenesis of this tumor remains controversial. A case of metaplastic mammary carcinoma with osteoclast-like giant cells in a 72-year-old woman is reported with p53 mutational analysis. Microscopically, the tumor was composed of a dominant sarcomatous stromal component containing osteoclast-like giant cells and a minor component of intraductal carcinoma. Immunostaining for p53 revealed strong positivity in both intraductal and sarcomatous components, but not in osteoclast-like giant cells. Mutational analysis of the p53 gene disclosed an identical point mutation in both intraductal and sarcomatous components, but not in osteoclast-like giant cells, indicating that both components share the same progenitor cells, and osteoclast-like giant cells represent a reactive infiltrate.
authors.affiliation: Department of Pathology, Seonam University, College of Medicine, 720 Kwangchi-Dong, Namwon, 590-711 Chollabuk-Do, Korea. jshinlee@hanmail.net
authors.forename: Ji Shin
authors.initials: JS
authors.lastname: Lee
authors.forename: Young Bog
authors.initials: YB
authors.lastname: Kim
authors.forename: Kyung Whan
authors.initials: KW
authors.lastname: Min
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology*; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D015726:Giant Cells / Q000166:cytology*; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia / Q000473:pathology; D042282:Microdissection; D010010:Osteoclasts / Q000166:cytology; D017354:Point Mutation; D016133:Polymerase Chain Reaction