Sera of lung cancer patients affect the release of Th1, Th2 and monocyte-derived cytokines, and the expression of IL-2Ralpha by normal, stimulated mononuclear cells.
We have shown that the sera of lung cancer patients affect the response of ConA-stimulated normal peripheral blood mononuclear cells by decreasing the expression of IL-2Ralpha and inhibiting the release of IL-1beta and IL-2. A tendency to enhance the release of IL-6 was also observed. We conclude that an imbalance in the Th1/Th2 cytokine response, typical for cancer patients, may at least partly be related to soluble factors circulating in the patients' blood. We discuss a putative role of serum IL-10, IL-1ra, and soluble IL-2Ralpha in the effects observed.
Chechlińska
Magdalena
M
Department of Immunology, The Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgena 5, 02-781 Warsaw, Poland. chech@coi.waw.pl
Duma
Anna
A
Swierkowska
Krystyna
K
Kamińska
Janina
J
Steffen
Jan
J
D000230:Adenocarcinoma / Q000276:immunology; D000328:Adult; D000368:Aged; D018287:Carcinoma, Large Cell / Q000276:immunology; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D003208:Concanavalin A / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D018123:Receptors, Interleukin / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D044967:Serum / Q000737:chemistry*
D016207:Cytokines; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D018123:Receptors, Interleukin; D015375:Receptors, Interleukin-2; D003208:Concanavalin A