The coactivator LXXLL nuclear receptor recognition motif.
Nuclear receptors require coactivator binding in order to activate transcription of their cognate target genes. Ligands regulate nuclear receptor (NR)-mediated recruitment of coactivators by binding to the ligand-binding domain of the receptor and inducing a conformational change allowing for recognition of a specific motif contained within the coactivator protein. This motif is known as the NR box or LXXLL (where L is leucine and X is any amino acid) domain. Here, we review the discovery of the domain as well as its characterization.
Savkur
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Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
Burris
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D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D047628:Estrogen Receptor alpha; D007930:Leucine / Q000737:chemistry; D008024:Ligands; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000737:chemistry* / Q000378:metabolism; D011960:Receptors, Estrogen / Q000819:agonists / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism
D047628:Estrogen Receptor alpha; D008024:Ligands; D009842:Oligopeptides; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D014157:Transcription Factors; D007930:Leucine