title: Albendazole versus metronidazole treatment of adult giardiasis: An open randomized clinical study.
abstract: OBJECTIVE
  To investigate the efficacy and tolerability of albendazole and metranidazole treatment in giardiasis.
  
  
  METHODS
  The open comparative randomized trial was carried out prospectively from December 1999 to July 2001 in Duzce City of Turkey. The diagnosis was based on the presence of signs and symptoms compatible with giardiasis including a positive stool examination of giardia cysts or trophozoite. Metranidazole group consisted of 29 patients and was given metranidazole 500 mg, three times a day for 5 d and albendazole group was consisted of 28 patients and was given albendazole 400 mg/d for 5 d.
  
  
  RESULTS
  There were no significant differences in demographical and therapeutical effects and patient's compliance between both groups. But side effects were seen more in metranidazole group than in albendazole group.
  
  
  CONCLUSIONS
  Albendazole is as effective as metranidazole in adults' giardiasis. Albendazole has less side effect potentials than metranidazole in the treatment of giardiasis.
authors.affiliation: Izzet Baysal Medical Faculty Infectious Disease Unit. Golkoy Kampusu/Bolu /Turkey. drkarabay@yahoo.com
authors.forename: Oguz
authors.initials: O
authors.lastname: Karabay
authors.forename: Ali
authors.initials: A
authors.lastname: Tamer
authors.forename: Huseyin
authors.initials: H
authors.lastname: Gunduz
authors.forename: Derya
authors.initials: D
authors.lastname: Kayas
authors.forename: Huseyin
authors.initials: H
authors.lastname: Arinc
authors.forename: Harika
authors.initials: H
authors.lastname: Celebi
mesh_terms: D000328:Adult; D015766:Albendazole / Q000008:administration & dosage*; D000981:Antiprotozoal Agents / Q000008:administration & dosage*; D000994:Antitrichomonal Agents / Q000008:administration & dosage*; D005260:Female; D005873:Giardiasis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D000994:Antitrichomonal Agents; D008795:Metronidazole; D015766:Albendazole