Guillain-Barre-Strohl syndrome unraveled as paraneoplastic syndrome of B-cell acute lymphoblastic leukemia in a patient with preceding common variable immunodeficiency syndrome with Evans syndrome.
A 26-year-old man with a history of common variable immunodeficiency and Evans syndrome (immunthrombocytopenia and immunhemolytic anemia) with sarcoid like lesions and lymph node enlargements in the previous history is described. The patient presented with symptoms resembling Guillain-Barre-Strohl as paraneoplastic syndrome just before the diagnosis of acute lymphoblastic leukemia of the L3 type. The patient was treated according to the B-ALL protocol of the German ALL study group and achieved a complete response after six cycles of chemotherapy together with a resolution of all neurologic symptoms.
Mailänder
Volker
V
Medizinische Klinik III, Hämatologie, Onkologie und Transfusionsmedizin, Universitätsklinikum Benjamin-Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 Berlin, Germany.
Gleisner
Beate
B
Blau
Igor Wolfgang
IW
Thiel
Eckhard
E
D000328:Adult; D000740:Anemia / Q000276:immunology / Q000473:pathology*; D001853:Bone Marrow / Q000473:pathology; D002051:Burkitt Lymphoma / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D014057:Tomography, X-Ray Computed