title: Phosphine-mediated reductive condensation of gamma-acyloxy butynoates: a diversity oriented strategy for the construction of substituted furans.
abstract: Exposure of gamma-acyloxy butynoates to stoichiometric quantities of triphenylphosphine results in reductive condensation to afford substituted furans, by way of allenic ester intermediates. As gamma-acyloxy butynoates are readily obtained through condensation of ethyl propiolate with aldehydes followed by acylation, this method represents a powerful and mechanistically novel protocol for the convergent three-component construction of substituted furans.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, USA.
authors.forename: Cheol-Kyu
authors.initials: CK
authors.lastname: Jung
authors.forename: Jian-Cheng
authors.initials: JC
authors.lastname: Wang
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Krische