[Evaluation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in peri-implant sulcular fluid].
OBJECTIVE
To investigate the levels of MMP-9 and TIMP-1 in healthy and diseased peri-implant tissue.


METHODS
Fifty-one implants in 39 patients were selected and divided into the healthy group and the inflammatory group according to the absence or presence of gingival redness, bleeding on probing, and progressive horizontal absorption of alveolar bone. The clinical parameters included: depth of gingival pocket(PD), plaque & calculus index (PLI), gingival bleeding index (GBI), and MMP-9, TIMP-1 levels in peri-implant sulcular fluid (PISF).


RESULTS
PD, PLI, GBI and MMP-9 levels were significantly higher in inflammatory group than in healthy group (P < 0.001).


CONCLUSIONS
MMP-9 level in PISF was closely associated with the clinical parameters.
Lu
Shao-heng
SH
Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Liang
Xing
X
Xie
Zhi-gang
ZG
Zhang
Jing-yi
JY
Xu
Ling
L
Sun
Hui-qiang
HQ
D000328:Adult; D015921:Dental Implants; D004797:Enzyme-Linked Immunosorbent Assay; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D008875:Middle Aged; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000032:analysis*
D015921:Dental Implants; D019715:Tissue Inhibitor of Metalloproteinase-1; D020780:Matrix Metalloproteinase 9