title: Undifferentiated spindle and giant cell carcinoma of the common bile duct.
abstract: Undifferentiated spindle and giant cell carcinoma of the common bile duct has not been reported previously. We present here a case of 71-year-old man with the undifferentiated spindle and giant cell carcinoma of the common bile duct, including immunohistochemical findings. A nodular infiltrating tumor was located at the lower portion of the extrahepatic bile duct, and measured 1.2 x 0.6 cm in size. Histologically, the tumor was composed of proliferated sarcomatoid spindle tumor cells. Numerous multinucleated giant cells were intermingled with the sarcomatoid spindle tumor cells. Immunohistochemically, the tumor cells were positive for both cytokeratin and vimentin. We speculated that the tumor originated from epithelial cells, and showed sarcomatoid neplastic changes.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Dowaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kashiwagi
authors.forename: Kosuke
authors.initials: K
authors.lastname: Tobita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohtani
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sugio
authors.forename: Takafumi
authors.initials: T
authors.lastname: Sekka
authors.forename: R Yoshiyuki
authors.initials: RY
authors.lastname: Osamura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Imaizumi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000473:pathology*; D014408:Biomarkers, Tumor; D018286:Carcinoma, Giant Cell / Q000175:diagnosis / Q000473:pathology*; D003135:Common Bile Duct / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D008297:Male
chemical_list: D014408:Biomarkers, Tumor