Comparison of different ibuprofen-amino acid compounds with respect to emulsifying and cytotoxic properties.
Sodium ibuprofen (Ibu-Na) and different ibuprofen-amino acid compounds, lysinate (Ibu-Lys), arginate (Ibu-Arg) and histidinate (Ibu-His), were evaluated for emulsifying, haemolytic and cytotoxic properties. The highest reduction of surface tension was obtained with Ibu-Lys which shows good emulsifying qualities. At the same time, Ibu-Lys reveals the highest haemolytic activity and affects porcine cornea integrity. However, incorporation of Ibu-Lys into an emulsion system significantly decreases haemolysis. On the contrary Ibu-Arg, which shows a lower surface tension reduction, allows, unlike Ibu-Na and Ibu-His, for comparably stable emulsions with comparable erythrocyte damage.
Baydoun
Luma
L
Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Mendelssohnstr. 1, 38106 Braunschweig, Germany.
Düvel
Andreas
A
Daniels
Rolf
R
Drust
Andreas
A
Goldhagen
Thorsten
T
Schwan
Irina
I
Zeidler
Christian
C
Müller-Goymann
Christel C
CC
D000328:Adult; D000818:Animals; D001120:Arginine / Q000633:toxicity*; D003315:Cornea / Q000187:drug effects; D004338:Drug Combinations; D004355:Drug Stability; D045703:Emulsifying Agents / Q000737:chemistry / Q000633:toxicity*; D004655:Emulsions; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007052:Ibuprofen / Q000031:analogs & derivatives / Q000737:chemistry / Q000633:toxicity*; D008239:Lysine / Q000031:analogs & derivatives / Q000633:toxicity*; D008297:Male; D013500:Surface Tension / Q000187:drug effects; D013552:Swine
D004338:Drug Combinations; D045703:Emulsifying Agents; D004655:Emulsions; D001120:Arginine; D008239:Lysine; C016106:solufenum; D007052:Ibuprofen; C106674:ibuprofen arginine