title: Evolution of angiographic restenosis rate and late lumen loss after intracoronary beta radiation for in-stent restenotic lesions.
abstract: The aim of this study was to investigate the time course of angiographic restenosis rate and late loss after successful percutaneous coronary intervention and vascular brachytherapy with beta-irradiation using strontium-90/yttrium-90 in 98 patients who were prospectively enrolled into a quantitative angiographic and clinical follow-up protocol at 6, 12, and 24 months after the index procedure, regardless of their symptom status. Actuarial restenosis rates measured 11.2 +/- 5% at 6 months of follow-up, 24.5 +/- 5% at 12 months, and 28.5 +/- 6% at 24 months, respectively. Late loss of the stent segment during the first 6 months measured 0.38 +/- 0.40 mm (6 to 12 months: 0.25 +/- 0.38 mm; 12 to 24 months: 0.16 +/- 0.32 mm), of the injured segment 0.27 +/- 0.21 mm (6 to 12 months: 0.21 +/- 0.26 mm; 12 to 24 months: 0.13 +/- 0.24 mm), of the irradiated segment 0.18 +/- 0.29 mm (6 to 12 months: 0.19 +/- 0.31 mm; 12 to 24 months: 0.11 +/- 0.27 mm), and of the analysis segment 0.18 +/- 0.36 mm (6 to 12 months: 0.17 +/- 0.29 mm; 12 to 24 months: 0.11 +/- 0.20 mm). Restenosis after angioplasty and beta-irradiation of in-stent restenotic lesions is not complete within 6 months but is sustained with a gradual decrease over 24 months.
authors.affiliation: Cardiology Division, Department of Medicine, Medizinische Klinik und Poliklinik-Innenstadt, University Hospital, Munich, Germany. Thomas.Schiele@medinn.med.uni-muenchen.de
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Schiele
authors.forename: Barbara
authors.initials: B
authors.lastname: Pöllinger
authors.forename: Ralf
authors.initials: R
authors.lastname: Kantlehner
authors.forename: Johannes
authors.initials: J
authors.lastname: Rieber
authors.forename: Andreas
authors.initials: A
authors.lastname: König
authors.forename: Viktória
authors.initials: V
authors.lastname: Seelig
authors.forename: Florian
authors.initials: F
authors.lastname: Krötz
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Sohn
authors.forename: Uwe
authors.initials: U
authors.lastname: Siebert
authors.forename: Eckhart
authors.initials: E
authors.lastname: Dühmke
authors.forename: Karl
authors.initials: K
authors.lastname: Theisen
authors.forename: Volker
authors.initials: V
authors.lastname: Klauss
mesh_terms: D000206:Actuarial Analysis; D000368:Aged; D001918:Brachytherapy; D017023:Coronary Angiography; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging* / Q000528:radiation effects*; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D013326:Strontium Radioisotopes / Q000627:therapeutic use; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes