Two new arylnaphthalide lignans and antiplatelet constituents from Justicia procumbens.
Two new arylnaphthalide lignans, procumphthalide A (1) and 4-O-beta-D-glucopyranosyl-(1"'-->2")-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC(50) value of about 27.6 microM.
Weng
Jing-Ru
JR
School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
Ko
Horng-Huey
HH
Yeh
Ting-Li
TL
Lin
Hsien-Cheng
HC
Lin
Chun-Nan
CN
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004837:Epinephrine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013566:Sympathomimetics / Q000037:antagonists & inhibitors / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D017705:Lignans; D010975:Platelet Aggregation Inhibitors; D013566:Sympathomimetics; D004837:Epinephrine