The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups.
In order to investigate the role of MBL gene polymorphisms in susceptibility to tuberculosis (TB) we genotyped 487 TB cases and 232 controls. Among African-American individuals, the frequency of B allele was lower among controls than cases (p < 0.01), but we found no differences between cases and controls of white and Hispanic ethnicity.
El Sahly
Hana M
HM
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Reich
Robert A
RA
Dou
Shu Jun
SJ
Musser
James M
JM
Graviss
Edward A
EA
D000328:Adult; D001741:Black or African American / Q000235:genetics; D000368:Aged; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000208:ethnology* / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics
D004269:DNA, Bacterial; D037601:Mannose-Binding Lectin