title: Growth inhibition of toxigenic fungi by a proteinaceous compound from Streptomyces sp. C/33-6.
abstract: A Streptomyces sp. strain named C/33-6, previously isolated from soil, presented a strong and specific antagonistic effect against toxigenic fungi. This action was attributed to a proteinaceous compound (molecular weight estimated to be 14 kDa) present in the supernatant of the culture of strain C/33-6, which was sensitive to proteinases (elastase, pronase E, proteinase K) and prolongated heat treatment (100 degrees C, for 20 min). This compound showed non-chitinolytic fungicidal activity.
authors.affiliation: Centro de Referencia de Micología (CEREMIC), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina. cfulgueira@yahoo.com.ar
authors.forename: Cecilia L
authors.initials: CL
authors.lastname: Fulgueira
authors.forename: Susana L
authors.initials: SL
authors.lastname: Amigot
authors.forename: Christian
authors.initials: C
authors.lastname: Magni
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D001426:Bacterial Proteins / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D002686:Chitin / Q000378:metabolism; D019286:Endopeptidase K / Q000378:metabolism; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D010196:Pancreatic Elastase / Q000378:metabolism; D011402:Pronase / Q000378:metabolism; D011489:Protein Denaturation; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D001426:Bacterial Proteins; D006131:Growth Inhibitors; D002686:Chitin; D010196:Pancreatic Elastase; D019286:Endopeptidase K; D011402:Pronase