title: Effect of gonadotropin-releasing hormone hypogonadism on insulin action as assessed by hyperglycemic clamp studies in men.
abstract: OBJECTIVE
  To investigate the effects of decreasing androgen levels on insulin action, in view of the relationship between hyperandrogenism and impaired insulin action in women with polycystic ovary syndrome.
  
  
  METHODS
  Prospective, clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Ten normal healthy men.
  
  
  METHODS
  Gonadotropin-releasing hormone (GnRH) agonist, 3.75 mg, administered monthly for 3 months.
  
  
  METHODS
  Insulin action (M/I ratio).
  
  
  RESULTS
  The M/I ratio decreased from 0.24 +/- 0.04 to 0.17 +/- 0.04 after GnRH agonist therapy.
  
  
  CONCLUSIONS
  In normal men, administration of a GnRH analogue was associated with a decrease in both testosterone levels and insulin action.
authors.affiliation: Division of Reproductive Endocrine and Infertility, Department of Obstetrics and Gynecology, Wayne State University /Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA.
authors.forename: Subodhsingh
authors.initials: S
authors.lastname: Chauhan
authors.forename: Karen
authors.initials: K
authors.lastname: Collins
authors.forename: Michael
authors.initials: M
authors.lastname: Kruger
authors.forename: Michael P
authors.initials: MP
authors.lastname: Diamond
mesh_terms: D000328:Adult; D015309:Glucose Clamp Technique; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007329:Insulin Antagonists / Q000494:pharmacology*; D016729:Leuprolide / Q000494:pharmacology*; D008297:Male; D012016:Reference Values; D013739:Testosterone / Q000037:antagonists & inhibitors
chemical_list: D007328:Insulin; D007329:Insulin Antagonists; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D016729:Leuprolide