[MRI-assisted thermometry for regional hyperthermia and interstitial laser thermotherapy].
OBJECTIVE
To demonstrate the potential of quantitative MRI-assisted thermometry for the treatment of tumor patients with regional hyperthermia (RHT) and interstitial laser thermotherapy (ILTT).


METHODS
Two patients and seven tissue samples were investigated using the T1-relaxation time and the chemical shift of the proton resonance frequency (PRF) as temperature sensitive MRI-parameters at 0.2 and 1.5 T. Thermotherapy was applied using either a dedicated MRI-hyperthermia hybrid system or a temperature controlled laser with 830 nm.


RESULTS
Both patients were treated successfully showing clinical benefit. T1 and PRF are depending on the applied thermotherapy method and on the MR-system suitable for MRI-assisted thermometry. The clinical application based on phantom results is not necessarily adequate.


CONCLUSIONS
Clinical application and phantom experiments of RHT and ILTT show the potential of MRI-assisted thermometry for further improvement of both minimal invasive thermotherapy methods. Further investigations concerning optimization of the MRI-techniques, the influence of perfusion or the determination of threshold values are necessary.
Peller
M
M
Institut für Klinische Radiologie, Klinikum Grosshadern der Ludwig-Maximilians-Universität München. michael.peller@med.uni-muenchen.de
Muacevic
A
A
Reinl
H
H
Sroka
R
R
Abdel-Rahman
S
S
Issels
R
R
Reiser
M F
MF
D000328:Adult; D001932:Brain Neoplasms / Q000628:therapy; D005240:Feasibility Studies; D005260:Female; D005266:Femoral Neoplasms / Q000628:therapy; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010865:Pilot Projects; D013813:Therapy, Computer-Assisted / Q000379:methods*; D013817:Thermography / Q000379:methods*; D016896:Treatment Outcome