title: [Effect of cigarette smoking on exhaled nitric oxide levels in healthy volunteers and patients with coronary heart disease].
abstract: Exhaled air contains nitric oxide in very low concentrations reaching several parts per billion. There are many factors which can influence exhaled nitric oxide levels (eNO), one of them is cigarette smoking.
  
  
  METHODS
  We investigated 78 patients: Group I (n = 26)--smokers, divided in two subgroups--I A healthy volunteers (n = 13) and I B--patients with coronary heart disease (CAD) (n = 13) Group II (n = 52)--nonsmokers. They were also divided in two subgroups--II A healthy volunteers (n = 21) and II B patients with CAD taking nitrates orally (n = 31) We use NO analyzer NOA 280 (Sievers Boulder Col. USA) with chemo-luminescence method
  
  
  RESULTS
  We found that eNO levels were significantly lower in smoking group than in nonsmokers. This fact was noticed in whole investigated population and in both subgroups,
  
  
  CONCLUSIONS
  1. Cigarette smoking significantly lowers exhaled nitric oxide levels and should be always taken into account during interpretation of the results. 2. Cigarette smoking significantly lowers exhaled nitric oxide levels even with of oral nitrates therapy.
authors.affiliation: Oddział Kliniczny Kardioanestezji i Intensywnej Terapii Pooperacyjnej Slaskiej Akademii Medycznej, Slaskim Centrum Chorób Serca w Zabrzu.
authors.forename: Nadziakiewicz
authors.initials: N
authors.lastname: Paweł
authors.forename: Knapik
authors.initials: K
authors.lastname: Piotr
authors.forename: Ziora
authors.initials: Z
authors.lastname: Dariusz
authors.forename: Rozentryt
authors.initials: R
authors.lastname: Piotr
mesh_terms: D000284:Administration, Oral; D000328:Adult; D016022:Case-Control Studies; D003327:Coronary Disease / Q000378:metabolism*; D045853:Exhalation; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D009566:Nitrates; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase