title: Rheological determinants in patients with Gaucher disease and internal inflammation.
abstract: The purpose of this study was to determine whether the inflammatory response in patients with Gaucher disease (GD) is accompanied by enhanced adhesiveness/aggregation of both red and white blood cells. Sixty patients with GD and matched controls were included. The degree of erythrocyte and leukocyte adhesiveness/aggregation was determined by using a simple slide test and image analysis. Patients with GD had significantly elevated concentrations of fibrinogen (328 vs. 262 mg/dl, P < 0.0001) and accelerated erythrocyte sedimentation rates (27 vs. 13 mm/H, P < 0.005). This was accompanied by a significantly enhanced degree of erythrocyte (75 vs. 85, P < 0.0001) and leukocyte (3.5 vs. 1.3, P < 0.002) adhesiveness/aggregation. The low-grade, smoldering, and subclinical internal inflammation in individuals with GD is accompanied by an increased degree of erythrocyte and leukocyte adhesiveness/aggregation. These findings might have rheological consequences in terms of microcirculatory slow flow and tissue hypoxemia.
authors.affiliation: Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
authors.forename: Ari
authors.initials: A
authors.lastname: Zimran
authors.forename: Amir
authors.initials: A
authors.lastname: Bashkin
authors.forename: Deborah
authors.initials: D
authors.lastname: Elstein
authors.forename: Bernard
authors.initials: B
authors.lastname: Rudensky
authors.forename: Rivka
authors.initials: R
authors.lastname: Rotstein
authors.forename: Meirav
authors.initials: M
authors.lastname: Rozenblat
authors.forename: Tamar
authors.initials: T
authors.lastname: Mardi
authors.forename: David
authors.initials: D
authors.lastname: Zeltser
authors.forename: Varda
authors.initials: V
authors.lastname: Deutsch
authors.forename: Itzhak
authors.initials: I
authors.lastname: Shapira
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
mesh_terms: D000328:Adult; D001799:Blood Sedimentation; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000502:physiology; D002449:Cell Aggregation / Q000502:physiology; D003176:Complement C3 / Q000032:analysis; D004903:Erythrocyte Aggregation / Q000502:physiology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005776:Gaucher Disease / Q000097:blood* / Q000276:immunology; D018056:Hemorheology / Q000379:methods; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007249:Inflammation / Q000097:blood; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric
chemical_list: D003176:Complement C3; D007136:Immunoglobulins; D005340:Fibrinogen