title: Lung fractional moving blood volume in normally grown and growth restricted foetuses.
abstract: OBJECTIVE
  To examine foetal lung blood perfusion using power Doppler ultrasound (PDU) and to compare fractional moving blood volume (FMBV) and mean pixel intensity (MPI) estimations in the lungs of normally grown (NG) foetuses and foetuses with intrauterine growth restriction (IUGR) and also to correlate foetal lung FMBV and MPI with respiratory complications after birth.
  
  
  METHODS
  Lungs of 47 NG and 25 IUGR foetuses after 32 weeks of gestation were examined with PDU. FMBV and MPI were estimated in a defined region in the posterior part of the foetal lung closest to maternal abdominal wall. FMBV and MPI were correlated to foetal weight deviation and gestational age. Perinatal outcome and respiratory complications after birth were recorded in both groups.
  
  
  RESULTS
  There were significantly lower FMBV and MPI values in IUGR than in NG foetuses. The overall variation was lower for FMBV than for MPI. There was a slightly higher correlation between FMBV and foetal weight deviation [r = 0.33, 95% confidence intervals (CI) 0.11-0.52] than between MPI and foetal weight deviation (r = 0.26, 95% CI 0.03-0.46). There was no significant correlation between FMBV or MPI and gestational age. No differences between the groups were found in the rate of respiratory complications, and they were not correlated either to the FMBV or MPI.
  
  
  CONCLUSIONS
  FMBV and MPI, estimated from the PDU signals of foetal lung circulation, showed lower values in third-trimester pregnancies complicated by IUGR. The frequency of neonatal respiratory complications was not increased in cases with low pulmonary FMBV and MPI values.
authors.affiliation: Department of Obstetrics and Gynecology, University of Lund, Lund, Sweden. edgar.hernandez-andrade@gyn.lu.se
authors.forename: Edgar
authors.initials: E
authors.lastname: Hernandez-Andrade
authors.forename: Ann
authors.initials: A
authors.lastname: Thuring-Jönsson
authors.forename: Tomas
authors.initials: T
authors.lastname: Jansson
authors.forename: Göran
authors.initials: G
authors.lastname: Lingman
authors.forename: Karel
authors.initials: K
authors.lastname: Marsàl
mesh_terms: D001810:Blood Volume; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000196:embryology* / Q000473:pathology / Q000503:physiopathology*; D020567:Fetal Weight; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D016014:Linear Models; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011652:Pulmonary Circulation