Scleritodermin A, a cytotoxic cyclic peptide from the lithistid sponge Scleritoderma nodosum.
The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
Schmidt
Eric W
EW
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA. ews1@utah.edu
Raventos-Suarez
Carmen
C
Bifano
Marc
M
Menendez
Ana T
AT
Fairchild
Craig R
CR
Faulkner
D John
DJ
D000818:Animals; D000970:Antineoplastic Agents; D001921:Brain / Q000187:drug effects; D002417:Cattle; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D050257:Tubulin Modulators; D014407:Tumor Cells, Cultured; D014747:Vinblastine / Q000494:pharmacology
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; D050257:Tubulin Modulators; C484931:scleritodermin A; D014747:Vinblastine