title: Acute exposure to environmental tobacco smoke reduces HDL-C and HDL2-C.
abstract: BACKGROUND
  Chronic environmental tobacco smoke (ETS) exposure increases individuals risk of coronary artery disease by reducing high-density lipoprotein cholesterol (HDL-C). Currently, there is limited research on the acute effects of ETS on HDL-C. This study examined the acute influence of ETS on HDL-C and its subfractions.
  
  
  METHODS
  Twelve male subjects (25.7 +/- 3.0 years) were examined to determine the influence of an acute 6-h exposure to ETS on lipid and lipoprotein levels. Baseline blood samples were drawn before ETS exposure from an antecubital vein at 6 am, 2 pm, and 10 pm. The following day, subjects were exposed to 6 h of ETS, approximately 4-10 pm. Blood was again collected at 8, 16 and 24 h following ETS exposure. Blood was assayed for total cholesterol (TC), HDL-C and its subfractions HDL(2)-C and HDL(3)-C.
  
  
  RESULTS
  As a result of ETS exposure, HDL-C and HDL(2)-C levels were significantly reduced by 18% and 37%, respectively. This effect was sustained, with a decrease in HDL-C of 13% and HDL2-C of 28% still evident at 24-h post-exposure. TC was unchanged (pre- 187.3 +/- 41.6 and post- 187.0 +/- 46.3); however, there were significant decreases in the TC/HDL-C and HDL2-C/HDL3-C ratios by 16% and 29%, respectively, which were sustained for 24 h.
  
  
  CONCLUSIONS
  The findings of this study demonstrate that a 6-h exposure has a negative impact on lipid and lipoprotein profiles and that these levels remained depressed for at least 24 h.
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, 32306-1493, USA. rmoffatt@mailer.fsu.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Moffatt
authors.forename: Sara A
authors.initials: SA
authors.lastname: Chelland
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Pecott
authors.forename: Bryant A
authors.initials: BA
authors.lastname: Stamford
mesh_terms: D000328:Adult; D002248:Carbon Monoxide / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood*; D004781:Environmental Exposure; D005431:Florida; D006801:Humans; D008297:Male; D009538:Nicotine / Q000032:analysis; D014028:Tobacco Smoke Pollution
chemical_list: D008076:Cholesterol, HDL; D014028:Tobacco Smoke Pollution; D009538:Nicotine; D002248:Carbon Monoxide