[Observation of the biodegradation of domestic poly-DL-lactic acid plates in vivo]
OBJECTIVE:To analyze the degradation and related factors of domestic poly-DL-lactic acid(PDLLA) plates in vivo. METHODS: The artifical transverse fractures in mandibular bodies of dogs were created and internal fixed with domestic PDLLA plates as experimental group,the implanted PDLLA plates in femurs as control.A certain time after the operation,the plates in fractured and implanted regions were collected and undertaken macroscopy and scanning electromicroscopy(SEM),meanwhile the fracture-healing status was evaluated. RESULTS: With time going on,the surface of domestic PDLLA plates y and density of micro-holes among poly-DL-lactic acid molecules in the PDLLA plates increased gradually.16-20 weeks Domestic PDLLA plates can be gradually biodegradation in vivo,in which it is correspondent with and accelerative the fracture-healing process.
Wang
W
W
Department of Oral and Maxillofacial Surgery,School of Stomatology,Shanghai Second Medical University.Shanghai 200011, China.
Qiu
W L
WL
Yuan
W H
WH
Hu
Q G
QG
Shen
J
J
Chen
Q
Q