title: Intralesional 5-fluorouracil in the treatment of keloid scars.
abstract: Two patients with keloid scars are described. The first patient presented with extensive keloid scarring on both cheeks secondary to acne. The second patient developed a keloid scar on her chest following excision of a mole. Both patients' scars were diagnosed clinically and treated with fortnightly injections of a mixture of 5-fluorouracil and betamethasone acetate and betamethasone sodium phosphate. At each injection session up to 1.6 mL of 5-fluorouracil at a concentration of 500 mg/10 mL and 0.4 mL of betamethasone acetate and betamethasone sodium phosphate (as betamethasone acetate 3 mg in suspension and betamethasone sodium phosphate 3.9 mg in solution) were used. Multiple treatments were required to obtain resolution of the keloid scars. Improvement was maintained in both patients at 1 year post treatment.
authors.affiliation: Specialist Cosmetic Laser Clinic, 8th Floor, Trak Centre, 445 Toorak Road, Toorak 5142, Melbourne, Victoria, Australia. greggoodman@greggoodman.com.au
authors.forename: Martine
authors.initials: M
authors.lastname: Apikian
authors.forename: Greg
authors.initials: G
authors.lastname: Goodman
mesh_terms: D000153:Acne Keloid / Q000188:drug therapy; D000328:Adult; D000963:Antimetabolites / Q000008:administration & dosage / Q000627:therapeutic use*; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005148:Facial Dermatoses / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000188:drug therapy*; D008297:Male; D013909:Thorax
chemical_list: D000963:Antimetabolites; D005938:Glucocorticoids; C028994:betamethasone sodium phosphate; D001623:Betamethasone; D005472:Fluorouracil