title: Surgical treatment of liver metastases by radiofrequency ablation, resection, or in combination.
abstract: OBJECTIVE
  Radiofrequency ablation (RFA) has a role in the treatment of unresectable liver metastases either percutaneously or in open surgery. The aim of this study was to determine the feasibility and value using RFA, resection or in combination to cure liver metastases of colorectal or other origin.
  
  
  METHODS
  Fifty-two consecutive patients were operated on with the intention to treat their liver metastases using both techniques of RFA and resection in the same curative intent. A CT scan was performed 2 months postoperatively and then every 4 months.
  
  
  RESULTS
  Fifty patients with 137 metastases could be treated: 55 lesions were resected and 82 were ablated. Curative treatment of 13 patients could only be achieved by using RFA combined with resection. Morbidity was 16% and local treatment proved insufficient in three cases. Estimated 1-year survival probabilities were, respectively, 0.85 in the colorectal group and 0.80 in the non-colorectal group.
  
  
  CONCLUSIONS
  RFA increased resectability of liver metastases and reduced the morbidity. Respective indications of both techniques were complementary and depend on the size and the topography of the lesion to be treated.
authors.affiliation: The Digestive Oncology Unit, Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France. evrard@bergonie.org
authors.forename: S
authors.initials: S
authors.lastname: Evrard
authors.forename: Y
authors.initials: Y
authors.lastname: Becouarn
authors.forename: M
authors.initials: M
authors.lastname: Fonck
authors.forename: R
authors.initials: R
authors.lastname: Brunet
authors.forename: S
authors.initials: S
authors.lastname: Mathoulin-Pelissier
authors.forename: V
authors.initials: V
authors.lastname: Picot
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation / Q000379:methods*; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010865:Pilot Projects; D011183:Postoperative Complications; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome