c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.
Extracellular electrophysiological recordings were used to study the firing rate of striatal neurons before and up to 4 h after intrastriatal c-fos antisense oligonucleotide injections in urethane-anesthetized rats. A four-fold increase from baseline neuronal activity was observed between 1 and 3 h upon antisense treatment, but not after control oligonucleotide injections. We conclude that, under urethane anesthesia, which here does not affect c-fos expression in the striatum by itself, neuronal activity appears to be tonically suppressed by basal striatal c-fos expression.
Strömberg
Ingrid
I
Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Hansson
Anita C
AC
Rimondini
Roberto
R
Sommer
Wolfgang
W
D000200:Action Potentials / Q000187:drug effects / Q000235:genetics*; D000758:Anesthesia; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D016762:Genes, fos / Q000187:drug effects / Q000235:genetics*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016376:Oligonucleotides, Antisense