title: Antinociceptive properties of chloromaleinimides and their sulphonyl derivatives.
abstract: This report describes the synthesis of new cyclic imides obtained from the reaction between aniline and dichloromaleic anhydride with further chlorosulphonation as well as the reaction between different amines and 4-methoxyphenol for the synthesis of imidobenzenesulphonyl derivatives. These compounds were tested as antinociceptive agents using the writhing test on mice. Some compounds, when intraperitoneally injected, proved to be potent and dose-related antinociceptives, being several times more active than many known reference drugs.
authors.affiliation: Laboratório de Síntese e Estrutura Atividade, Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis/SC, Brazil.
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Walter
authors.forename: Cristiano
authors.initials: C
authors.lastname: Mora
authors.forename: Karoline
authors.initials: K
authors.lastname: Mundstock
authors.forename: Mércia M
authors.initials: MM
authors.lastname: de Souza
authors.forename: Andréia
authors.initials: A
authors.lastname: de Oliveira Pinheiro
authors.forename: Rosendo Augusto
authors.initials: RA
authors.lastname: Yunes
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Nunes
mesh_terms: D000698:Analgesia; D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000700:Analgesics; D013449:Sulfonamides