title: Medical genetics: a marker for Stevens-Johnson syndrome.
abstract: Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.
authors.affiliation: Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Wen-Hung
authors.initials: WH
authors.lastname: Chung
authors.forename: Shuen-Iu
authors.initials: SI
authors.lastname: Hung
authors.forename: Hong-Shang
authors.initials: HS
authors.lastname: Hong
authors.forename: Mo-Song
authors.initials: MS
authors.lastname: Hsih
authors.forename: Li-Cheng
authors.initials: LC
authors.lastname: Yang
authors.forename: Hsin-Chun
authors.initials: HC
authors.lastname: Ho
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
authors.forename: Yuan-Tsong
authors.initials: YT
authors.lastname: Chen
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D004049:Diethylcarbamazine / Q000009:adverse effects; D015235:HLA-B Antigens / Q000235:genetics*; D059910:HLA-B15 Antigen; D006801:Humans; D015994:Incidence; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D015235:HLA-B Antigens; C483536:HLA-B*15:02 antigen; D059910:HLA-B15 Antigen; D004049:Diethylcarbamazine