title: The role of human herpes virus 6 and 7 in the pathogenesis of pityriasis rosea.
abstract: Pityriasis rosea (PR) is an acute exanthematous inflammatory skin disease in which many epidemiological studies suggest a viral infection in its pathogenesis. Several viruses such as picornaviruses, parvoviruses and herpes viruses were accused as causative agents in PR. Human herpes virus-6 (HHV-6) and HHV-7 are newly discovered members of herpesviridae family. Several diseases including roseola infantum and PR have been linked with HHV-6 and HHV-7 in dermatology. We aimed to investigate the role of HHV-6 and HHV-7 in the pathogenesis of PR. Blood samples from 35 patients with acute PR and 30 healthy volunteers were examined to obtain titres for HHV-6 and HHV-7 antibodies. Anti-HHV-6 and -HHV-7 immunoglobulin (Ig) G antibodies were detected by IFA. The high titres of anti-HHV-6 IgG were determined in four patients and anti-HHV-7 IgG in only two of four patients. In our study, we haven't found any significant relationship between HHV-6, HHV-7 and PR. Our results were supported with the data of several previous studies.
authors.affiliation: Department of Dermatology, University of Suleyman Demirel Faculty of Medicine, Isparta, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Yildirim
authors.forename: B C
authors.initials: BC
authors.lastname: Aridogan
authors.forename: V
authors.initials: V
authors.lastname: Baysal
authors.forename: H S
authors.initials: HS
authors.lastname: Inaloz
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015654:Herpesvirus 6, Human; D016199:Herpesvirus 7, Human; D006801:Humans; D008297:Male; D017515:Pityriasis Rosea / Q000188:drug therapy / Q000821:virology*; D019349:Roseolovirus Infections / Q000150:complications*