Infectious complications of implantable venous access devices in patients with sickle cell disease.
OBJECTIVE
To evaluate the incidence of implantable venous access device infection in patients with sickle cell disease.


METHODS
The authors performed a retrospective search of their hospital's information system from January 1, 1996 to December 31, 2001 to identify hospital admissions with ICD-9 codes related to sickle cell anemia. This search yielded 2703 admissions in 293 patients. A search of the radiology information system identified 23 of these patients who had placement of an implantable venous access device. Excluding two patients who were lost to follow-up, the population of this study included eight men and 13 women aged 23 to 62 years old (mean, 37 years). A total of 30 implantable venous access devices (25 venous ports, five tunneled catheters) were placed by interventional radiologists. Cases of device infection were identified based on clinical data, microbiology, reports of device removal, and clinical follow-up. Infections were defined according to the Centers for Disease Control criteria for catheter-related bloodstream infection. The incidence of infection, organism, and time from device placement to infection was determined.


RESULTS
In 21 patients with 30 devices, 18 device infections (60%) occurred in 12 patients (57%) involving 15 venous ports and three tunneled catheters. There were a total of 12389 days of catheter use and a rate of 1.5 infections per 1000 catheter days. Infections occurred from 16 to 1542 days (mean, 349 days) after device placement. Blood, wound, and catheter tip cultures yielded solitary organisms in 13 cases and mixed organisms in four cases. Staphylococcus aureus was the most common pathogen (59%). One patient was considered infected based on clinical signs and purulent discharge from the port site, despite negative cultures after partial antibiotic treatment. One patient died of sepsis resulting from an infected port.


CONCLUSIONS
This study shows a high incidence of infection associated with placement of implantable venous access devices in patients with sickle cell disease. Therefore, the authors avoid placing these devices in this patient population.
Wagner
Steven C
SC
Division of Cardiovascular and Interventional Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania 19107, USA.
Eschelman
David J
DJ
Gonsalves
Carin F
CF
Bonn
Joseph
J
Sullivan
Kevin L
KL
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D020878:Device Removal; D004867:Equipment Design; D004868:Equipment Failure; D005260:Female; D005500:Follow-Up Studies; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D006450:Hemoglobin SC Disease / Q000382:microbiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D017211:Treatment Failure
D000900:Anti-Bacterial Agents