title: Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy.
abstract: Previous studies have shown a selective accumulation of 5-aminolevulinic acid (ALA)-derived protoporphrin IX (PpIX) in oral premalignant and malignant tissues. This provides a biologic rationale for the clinical use of ALA-mediated PDT (ALA-PDT) for oral premalignant and malignant lesions. In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA-PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635+/-5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm(2); light exposure dose, 100 J/cm(2)) after topical application of 20% ALA for 1.5 or 2 h. Topical ALA-PDT was repeated once a week until the complete regression of the lesion. Complete regression of all OVH lesions was observed after 1-3 treatments (average, 2 treatments) of topical ALA-PDT. At an average follow-up of 5.6 months (range, 3-11 months), all the five OVH patients were free of tumor recurrence. We conclude that topical ALA-PDT with fractionated irradiations by an LED red light at 635+/-5 nm is an effective and successful treatment modality for OVH.
authors.affiliation: School of Dentistry, National Taiwan University Hospital, National Taiwan University, 1 Chang-Te Street, Taipei 100, Taiwan.
authors.forename: Hsin-Ming
authors.initials: HM
authors.lastname: Chen
authors.forename: Chin-Tin
authors.initials: CT
authors.lastname: Chen
authors.forename: Hsiang
authors.initials: H
authors.lastname: Yang
authors.forename: Mark Yen-Ping
authors.initials: MY
authors.lastname: Kuo
authors.forename: Ying-Shiung
authors.initials: YS
authors.lastname: Kuo
authors.forename: Wan-Hong
authors.initials: WH
authors.lastname: Lan
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Tsuimin
authors.initials: T
authors.lastname: Tsai
authors.forename: Chun-Pin
authors.initials: CP
authors.lastname: Chiang
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage*; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy* / Q000473:pathology; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000473:pathology; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000473:pathology; D013050:Spectrometry, Fluorescence / Q000379:methods; D016896:Treatment Outcome; D014860:Warts / Q000188:drug therapy* / Q000473:pathology
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid