title: [Cutaneous nocardiosis as an opportunistic infection].
abstract: A 46-year-old man who had been treated with azathioprine and budesonide for Crohn's disease for the past eight years developed a purulent skin condition on the right ring finger. Despite surgical drainage and treatment with amoxicillin and flucloxacillin, the condition spread itself over the hand and lower arm, partly per continuum and partly in jumps. The patient did not feel ill and there were no systemic symptoms. Ultimately, Nocardia asteroides was cultured from the wound and complete cure was achieved after 8 months' treatment with co-trimoxazole. Infections with Nocardia spp. are rare but may occur more often and run a more fulminant course in patients under treatment with immunosuppressants. Cutaneous nocardiosis generally has a characteristic lymphogenous spreading pattern, but an atypical picture with pustules, pyoderma, cellulitis or abscess formation is also possible. In non-cutaneous nocardiosis there is usually pneumonia or lung abscess, possibly with secondary haematogenous spread to the central nervous system or skin. Culturing Nocardia requires more time than usual but can be promoted by special culture media. Treatment of the infection with co-trimoxazole is the method of choice and is almost always successful in cases of cutaneous nocardiosis.
authors.affiliation: Afd. Longziekten, Academisch Medisch Centrum/Universiteit van Amsterdam, Postbus 22.660, 1100 DD Amsterdam. h.j.bogaard@amc.uva.nl
authors.forename: H J
authors.initials: HJ
authors.lastname: Bogaard
authors.forename: G W
authors.initials: GW
authors.lastname: Erkelens
authors.forename: W R
authors.initials: WR
authors.lastname: Faber
authors.forename: P J
authors.initials: PJ
authors.lastname: de Vries
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009616:Nocardia asteroides / Q000302:isolation & purification / Q000472:pathogenicity*; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D007166:Immunosuppressive Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination