[Role of advanced glycosylation end products in the pathogenesis of hypertension].
Advanced glycosylation end products (AGEs) are involved in the patho-genesis of diabetes mellitus, end stage renal failure, hypertension and its complications. The influence of AGEs on hypertension is exerted by oxidative stress, vascular remodelling, impaired nitric oxide metabolism, and immunological disturbances. The investigations aiming to explain the reasons of disturbed metabolism of AGEs in hypertension will implicate therapeutic interventions.
Zukowska-Szczechowska
Ewa
E
Katedra i Klinika Chorób Wewnetrznych, Diabetologii i Nefrologii, Slaskiej Akademii Medycznej w Katowicach.
Tomaszewski
Maciej
M
Grzeszczak
Władysław
W
D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D005609:Free Radicals / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism
D005609:Free Radicals; D017127:Glycation End Products, Advanced; D017382:Reactive Oxygen Species; D011971:Receptors, Immunologic; D009569:Nitric Oxide