title: Obesity-related excess mortality rate in an adult intensive care unit: A risk-adjusted matched cohort study.
abstract: OBJECTIVE
  To evaluate the obesity-related mortality rate in an intensive care unit.
  
  
  METHODS
  An exposed/unexposed matched cohort study.
  
  
  METHODS
  An 18-bed adult medical-surgical intensive care unit in a 1,100-bed regional and teaching hospital in France.
  
  
  METHODS
  From January 1, 1999, to December 31, 2001, 170 mechanically ventilated exposed patients (obese patients with body mass index of >30 kg/m) were matched with 170 mechanically ventilated unexposed patients (with ideal body mass index of 18.5-24.9 kg/m).
  
  
  METHODS
  None.
  
  
  RESULTS
  The matching process was conducted according to eight criteria: cause of admission, indication for ventilatory support, immunologic status, cardiac status, probability of death (+/-5%), age (+/-7 yrs), gender, and acquisition of severe events appearing within 24 hrs before admission (defined as resuscitated cardiac arrest, acute respiratory distress syndrome, or septic shock). The mortality rate between exposed and unexposed patients was compared by univariate analysis and then was adjusted for other possible confounding factors by multivariate analysis, using conditional logistic regression. The matching process was successful for 1,360 of 1,360 criteria. Obesity was significantly associated with intensive care unit mortality (odds ratio, 2.1; 95% confidence interval, 1.2-3.6). Obesity-related excess mortality was verified mainly for the youngest patients (odds ratio, 2.5; 95% confidence interval, 1.6-6.1) and for the patients with a probability of intensive care unit death of 11-50% (odds ratio, 2.6; 95% confidence interval, 1.2-5.5). This excess mortality rate could be explained by the higher risk of intensive care unit acquired complications among obese patients than among the unexposed ones (odds ratio, 4; 95% confidence interval, 1.4-11.8).
  
  
  CONCLUSIONS
  Obesity is an independent risk factor for intensive care unit death and should be regarded as a severe comorbidity in such units.
authors.affiliation: Service de Réanimation Médicale Polyvalente, Centre Hospitalier Régional d'Orléans, Hôpital de la Source, Orléans, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bercault
authors.forename: Thierry
authors.initials: T
authors.lastname: Boulain
authors.forename: Kaldhoun
authors.initials: K
authors.lastname: Kuteifan
authors.forename: Manuel
authors.initials: M
authors.lastname: Wolf
authors.forename: Isabelle
authors.initials: I
authors.lastname: Runge
authors.forename: Jean-Christian
authors.initials: JC
authors.lastname: Fleury
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005602:France; D006323:Heart Arrest / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000401:mortality*; D016017:Odds Ratio; D011336:Probability; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000401:mortality; D012307:Risk Factors; D012772:Shock, Septic / Q000401:mortality; D016019:Survival Analysis