title: In vitro evaluation of percutaneous diffusion of uranyl nitrate through intact or excoriated skin of rat and pig.
abstract: At the present time, the International Commission on Radiological Protection (ICRP) has not published any model concerning internal radioactive contamination by uptake from wounds. The aims of our work were to determine the time available to treat contamination of intact or wounded skin before a significant uptake of uranium occurred and to evaluate the consequences of incomplete decontamination on uranium uptake. The kinetics of percutaneous diffusion of uranium through intact or excoriated skin and its distribution in skin layers were evaluated using an in vitro technique. Our data demonstrated a dramatic increase of uranium percutaneous diffusion through excoriated skin compared with intact skin. Significant uptake of uranium through excoriated skin occurred in only 30 min, indicating that there is only a short interval available to treat a contaminated wound effectively. Moreover, in the case of an incompletely decontaminated superficial wound, viable epidermis behaved as a reservoir for uranium that remained bioavailable. At the present time, potential uptake of uranium and perhaps other radionuclides through intact or wounded skin is not adequately taken into account by radiological protection agencies. Our results emphasize the need for further study and modeling of uptake of radionuclides through intact or wounded skin.
authors.affiliation: Départment de Protection de la santé de l'Homme et de Dosimétrie, Institut de Radioprotection et de Sûreté Nucléaire, B.P. 166, 26707 Pierrelatte CEDEX, France. fabrice.petitot@irsn.fr
authors.forename: F
authors.initials: F
authors.lastname: Petitot
authors.forename: A M
authors.initials: AM
authors.lastname: Moreels
authors.forename: F
authors.initials: F
authors.lastname: Paquet
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003666:Decontamination; D004431:Ear, External; D004817:Epidermis / Q000293:injuries / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D012867:Skin / Q000293:injuries / Q000378:metabolism*; D012869:Skin Absorption; D012879:Skin Physiological Phenomena; D013045:Species Specificity; D013552:Swine; D014502:Uranyl Nitrate / Q000493:pharmacokinetics*; D014947:Wounds and Injuries / Q000378:metabolism
chemical_list: D014502:Uranyl Nitrate