A model explaining the size distribution of gene and protein families.
This article deals with the theoretical size distribution of gene and protein families in complete genomes. A simple evolutionary model for the development of such families in which genes in a family are formed or selected against independently and at random, and in which new families are formed by the random splitting of existing families, is used to derive the resulting size distribution. Mathematically this turns out to be the distribution of the state of a homogeneous birth-and-death process after an exponentially distributed time, which it is shown will under certain conditions exhibit the power-law behaviour observed for gene and protein family sizes.
Reed
William J
WJ
Department of Mathematics and Statistics, University of Victoria, P.O. Box 3045, Victoria, BC, Canada V8W 3P4. reed@math.uvic.ca
Hughes
Barry D
BD
D000465:Algorithms; D003198:Computer Simulation / Q000706:statistics & numerical data; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D030541:Databases, Genetic; D019143:Evolution, Molecular; D005796:Genes / Q000235:genetics*; D016678:Genome; D008957:Models, Genetic; D009154:Mutation; D011506:Proteins / Q000235:genetics*; D016008:Statistical Distributions
D011506:Proteins; D003577:Cytochrome P-450 Enzyme System