title: A case of lactic acidosis caused by stavudine in an AIDS patient.
abstract: Nucleoside reverse transcriptase inhibitors (NRTIs), which are used for the treatment of human immunodeficiency virus (HIV) infection have been associated with a wide spectrum of clinical manifestations, including hepatic steatosis, lipodystrophy, myopathy, and lactic acidosis. Such adverse effects are postulated to result from the inhibition of mitochondrial DNA gamma polymerase, which causes the depletion of mitochondrial DNA and eventual the disruption of oxidative phosphorylation. Although cases of severe decompensated lactic acidosis are rare, this syndrome is associated with a high mortality rate. We report upon the first Korean case, of severe lactic acidosis in an acquired immunodeficiency syndrome (AIDS) patient receiving stavudine, an anti-HIV drug.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Byoung Chul
authors.initials: BC
authors.lastname: Cho
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
authors.forename: Suk Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Chang
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D018119:Stavudine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D017693:Sodium Bicarbonate; D018119:Stavudine