title: [Effect of beta-adrenergic blocker propranolol during reflex renal degeneration induced by sciatic nerve transection].
abstract: We present the data on functional status of the mineralocorticoid receptor system in rat kidney in the course of renal reflex degeneration induced by sciatic nerve transection at the background of both renal denervation and injections of beta blocker propranolol. According to the status of renal mineralocorticoid receptors, simultaneous blocking of both neural and humoral pathological stimuli incoming to the kidney after the nerve injury to a higher extent inhibited cytochemical changes in the organ as compared to blocking the neural transmission alone. We propose that both the central neural transmission and humoral mechanisms control the activity of the molecular structures responsible for aldosterone reception in renal tubular cells.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, ul. Butlerova 5A, Moscow, 117865 Russia.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Akimov
authors.forename: N S
authors.initials: NS
authors.lastname: Kositsyn
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D003714:Denervation / Q000009:adverse effects* / Q000379:methods; D007668:Kidney / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism / Q000473:pathology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018161:Receptors, Mineralocorticoid / Q000187:drug effects / Q000378:metabolism; D012584:Sciatic Nerve / Q000601:surgery*; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D018161:Receptors, Mineralocorticoid; D000450:Aldosterone; D011433:Propranolol