Effect of imino group of a linker arm at the C5 position of a pyrimidine nucleoside on the thermal stabilities of DNA/DNA and DNA/RNA duplexes.
The modified ODN's bearing C5-substituted 2'-deoxyuridine derivative were synthesized by a post-synthetic modification with an unsymmetrical triamine. The effect of the C5-substituent on the duplex formation with complementary DNA or RNA differed with the position of an imino group in the linker-arms.
Ozaki
Hiroaki
H
Department of Chemistry, Faculty of Engineering, Gunma University, Kiryu, Gunma, Japan. ozaki@gunma-u.ac.jp
Mine
Masayuki
M
Shinozuka
Kazuo
K
Sawai
Hiroaki
H
D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000737:chemistry*; D006358:Hot Temperature; D007700:Kinetics; D011741:Pyrimidine Nucleosides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D020871:RNA Stability; D013056:Spectrophotometry, Ultraviolet
D011741:Pyrimidine Nucleosides; D012313:RNA; D004247:DNA