Four new triterpenoids from Maytenus ilicifolia.
Four new triterpenoids with various skeletons, maytefolins A-C (1-3) and uvaol-3-caffeate (4), were isolated from the leaves of a Brazilian medicinal plant, Maytenus ilicifolia, together with five known triterpenoids. Of these triterpenoids only erythrodiol exhibited significant cytotoxicity against KB/S, KB/VJ300, and KU 19-20 cells.
Ohsaki
Ayumi
A
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan. a-ohsaki.fm@tmd.ac.jp
Imai
Yoji
Y
Naruse
Meiko
M
Ayabe
Shin-Ichi
S
Komiyama
Kanki
K
Takashima
Junko
J
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D029755:Maytenus / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C484927:maytefolin A; C484928:maytefolin B; C484929:maytefolin C; C484930:uvaol-3-caffeate; C077953:erythrodiol; D009828:Oleanolic Acid