Inhibitory activity of indolin-2-one derivatives on compound 48/80-induced histamine release from mast cells.
Four alkaloids, previously identified in Isatis species, were tested for their inhibitory effect on histamine release. Whereas tryptanthrin, indirubin and deoxyvasicinone did not inhibit histamine release, the effect of indolin-2-one exceeded that of the mast cell stabilizing drug disodium chromoglycate.
Rüster
G U
GU
Institute of Pharmacy, Friedrich-Schiller-University, Jena, Germany.
Hoffmann
B
B
Hamburger
M
M
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D007211:Indoles; C456900:indolin-2-one; D003189:p-Methoxy-N-methylphenethylamine