title: [Mucositis--a major non-hematologic complication of high-dose chemotherapy and radiotherapy--pathogenesis, prevention and treatment].
abstract: High-dose chemotherapy and radiotherapy--induced oral mucositis (OM) represents a major non-hematologic complication of stem cell transplantation in cancer patients. This side effect causes significant treatment-related morbidity and is an important clinical problem because of the pain, odynodysphagia, the requirement for parenteral nutrition, narcotics and the risk of local infections which are exacerbated by the severe neutropenia and can become systemic. The pathogenesis of OM can be attributed to the direct mucosal toxicity of high-dose chemotherapy and ionizing radiation and to indirect mucosal damage caused by a concomitant local bacterial, viral and mycotic infections. This review describes pathophysiology as well as prophylactic and therapeutic armamentarium for the treatment of oral mucositis in patients receiving high dose chemotherapy and/or radiotherapy.
authors.affiliation: Katedra i Klinika Hematologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie. bjakubas@wp.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Piatkowska-Jakubas
authors.forename: Dagmara
authors.initials: D
authors.lastname: Darczuk
authors.forename: Maria
authors.initials: M
authors.lastname: Chomyszyn-Gajewska
authors.forename: Aleksander B
authors.initials: AB
authors.lastname: Skotnicki
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D009061:Mouth Mucosa / Q000187:drug effects / Q000528:radiation effects; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013280:Stomatitis / Q000209:etiology / Q000517:prevention & control / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents