title: Evaluation of optimization techniques for an extractive alcoholic fermentation process.
abstract: The mathematical optimization of a continuous alcoholic fermentation process combined with a flash column under vacuum was studied. The objective was to maximize % yield and productivity in the fermentor. The results using surface response analysis combined with modeling and simulation were compared withy those obtained when the problem was written as a nonlinear programming problem and was solved with a successive quadratic programming (SQP) technique. Two process models were evaluated when the process was optimized using the SQP technique. The first one is a deterministic model, whose kinetic parameters were experimentally determined as functions of the temperature, and the second is a statistical model obtained using the factorial design technique combined with simulation. Although the best result was the one obtained using the rigorous model, the values for productivity and % yield obtained using the simplified model are acceptable, and these models can be used when the development of a rigorous model is excessively difficult, slow, or expensive.
authors.affiliation: DPQ/FEQ/UNICAMP, Cx. Postal 6066, Campinas, SP, 13081-970 Brazil. accosta@feq.unicamp.br
authors.forename: Aline C
authors.initials: AC
authors.lastname: da Costa
authors.forename: Rubens Maciel
authors.initials: RM
authors.lastname: Filho
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000704:Analysis of Variance; D001709:Biotechnology / Q000379:methods*; D005285:Fermentation; D007700:Kinetics; D015233:Models, Statistical; D008962:Models, Theoretical; D012984:Software; D013696:Temperature
chemical_list: D000438:Alcohols