Association between longer duration of HIV-suppressive therapy and partial recovery of the V gamma 2 T cell receptor repertoire.
Human immunodeficiency virus (HIV) infection alters the function and repertoire of peripheral blood gamma delta T cells expressing the V gamma 2/V delta 2 T cell receptor (TCR). A cross-sectional comparison of the V gamma 2 TCR repertoire was performed for 56 HIV-infected subjects, 51 of whom were receiving highly active antiretroviral therapy (HAART), to measure changes in the V gamma 2 TCR repertoire. Longer durations of HAART were associated with partial recovery of the normal TCR repertoire, and recovery was greatest in subjects with complete virus suppression. Changes in the V gamma 2 TCR repertoire are sensitive measures for the effects of HAART and of residual HIV replication.
Bordon
Jose
J
Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA.
Evans
Peter S
PS
Propp
Nadia
N
Davis
Charles E
CE
Redfield
Robert R
RR
Pauza
C David
CD
D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003430:Cross-Sectional Studies; D005260:Female; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D019562:Viral Load
D016692:Receptors, Antigen, T-Cell, gamma-delta