Telomerase activity of peripheral blood mononuclear cells from patients with laryngeal carcinoma.
This study investigated the activity of telomerase in peripheral blood mononuclear cells (PBMCs) in patients with laryngeal carcinoma. We examined proliferative response to phytohemagglutinin and expression of telomerase activity of PBMCs from 30 patients with laryngeal carcinoma and 17 healthy volunteers. Both proliferative and telomerase activity of [circled times]PBMCs in the patient group was lower than that in the healthy volunteer group. Telomerase activity may play a permissive role in cell division and clonal expansion of the immune cells in response to laryngeal squamous carcinoma. It may be related to lymph node metastasis of laryngeal cancer.
Ge
PingJiang
P
Department of Otolaryngology, Peking Union Medical College Hospital, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences, & Peking Union Medical College, Beijing, China.
Zhang
BaoQuan
B
Zhang
JianMin
J
Gao
ZhiQiang
Z
He
Wei
W
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000201:enzymology*; D002455:Cell Division; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood* / Q000201:enzymology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000201:enzymology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D019098:Telomerase / Q000097:blood*
D019098:Telomerase