Elucidation of the mechanism of chiral selectivity in diastereomeric salt formation using organic solvent nanofiltration.
Organic solvent nanofiltration (OSN) was used to investigate the mechanism of chiral selectivity in diastereomeric salt formation of alpha-phenylethylamine with D-tartaric acid and di-p-toluoyl-D-tartaric acid as resolving agents; results indicate that for these systems chiral selectivity occurs only upon crystallisation and chiral interactions in solution were negligible.
Ghazali
Nazlee F
NF
Department of Chemical Engineering, Imperial College, Prince Consort Road, London SW7 2BY, UK.
Patterson
Darrell A
DA
Livingston
Andrew G
AG