Comparison of arterial assessments in low and high vascular disease risk groups.
BACKGROUND
An increasing number of arterial function assessments are available, including small and large arterial elasticity (SAE/C2, LAE/C1), endothelial function as measured by flow mediated dilation (FMD), carotid intima-medial thickness (IMT), ankle brachial index (ABI), pulse pressure (PP), and pulse wave velocity (PWV). We have consecutively performed these measures in subjects with low and high vascular disease risks to assess the interrelationships.


RESULTS
Twenty healthy subjects (HS) and 20 older subjects with type 2 diabetes mellitus (DM) were studied with all techniques at a single sitting by a single operator. In HS, C2 correlated with FMD (R = 0.577, P = .008), PWV (R = 0.522, P = .046), and ABI (R = 0.463, P = .04). There was no significant correlation of C1 and FMD or blood pressure (BP) measurements. In DM, C2 correlated with FMD (R = 0.443, P = .05), systolic BP (R = -0.553, P = .01), PP (R = -0.601, P = .005), and systemic vascular resistance (R = -0.577, P = .008). There was no significant correlation between anthropometric measures and arterial function measures in either group. The IMT was not correlated with any measure of arterial function in either group.


CONCLUSIONS
C2 assessed by pulse wave analysis correlated with endothelial function measured by FMD in young apparently healthy subjects and older subjects with type 2 diabetes. Systolic BP and PP correlated with C2 and FMD in older diabetic subjects but not healthy subjects. The interrelationships between arterial function measures are different in high and low risk populations. This variability needs to be considered when applying these techniques to individuals in different populations.
Wilson
Andrew M
AM
University of Melbourne, Department of Medicine, St. Vincent's Hospital, Melbourne, Australia. wilsonam@svhm.org.au
O'Neal
David
D
Nelson
Craig L
CL
Prior
David L
DL
Best
James D
JD
Jenkins
Alicia J
AJ
D000328:Adult; D000368:Aged; D000842:Ankle / Q000098:blood supply*; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D001916:Brachial Artery / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D013223:Statistics as Topic; D013599:Systole / Q000502:physiology; D017539:Tunica Intima / Q000503:physiopathology; D014652:Vascular Diseases / Q000453:epidemiology* / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology; D014664:Vasodilation / Q000502:physiology