title: Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+.
abstract: Symmetrical homometallic dinuclear complexes of the type [(Ru(dpq)2)2(phen-SOS-phen)]4+, with a flexible 2-mercaptoethyl ether linker joining the two [Ru(dpq)2(phen)]2+-based sub-units, have DNA dissociation constants (Kd) in the nM range.
authors.affiliation: School of Science, Food and Horticulture, College of Science, Technology and Environment, University of Western Sydney, Penrith South, NSW 1797, Australia. J.Aldrich-Wright@uws.edu.au
authors.forename: Janice
authors.initials: J
authors.lastname: Aldrich-Wright
authors.forename: Craig
authors.initials: C
authors.lastname: Brodie
authors.forename: Edith C
authors.initials: EC
authors.lastname: Glazer
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Luedtke
authors.forename: Lev
authors.initials: L
authors.lastname: Elson-Schwab
authors.forename: Yitzhak
authors.initials: Y
authors.lastname: Tor
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D015342:DNA Probes; D019281:Dimerization; D007364:Intercalating Agents / Q000737:chemistry*; D008024:Ligands; D008623:Mercaptoethanol / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D011810:Quinoxalines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D015342:DNA Probes; D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D010618:Phenanthrolines; D011725:Pyridines; D011743:Pyrimidines; D011810:Quinoxalines; D008623:Mercaptoethanol; D012428:Ruthenium; D004247:DNA