Coexistence of CJD and Alzheimer's disease: an autopsy case showing typical clinical features of CJD.
The present report concerns an autopsy case of CJD showing typical clinical features of CJD. The patient was a Japanese woman without hereditary burden or dementing disorder anamnesis who was 70-years-old at the time of death. She developed gait disturbance at age 68, followed by memory impairment, visual disturbance, and myoclonus. A neurological examination approximately 2 months after the disease onset revealed akinetic mutism, in addition to periodic synchronous discharges on electroencephalogram. Serial neuroradiological examinations disclosed progressive atrophy of the brain. She died of bronchopneumonia 25 months after the disease onset. The brain weighed 560 g (cerebrum 490 g, brainstem with cerebellum 70 g). Macroscopically, neuropathological examination showed prominent atrophy of the cerebrum, caudate nucleus, and cerebellum, in addition to necrosis of the cerebral white matter, compatible with panencephalopathic CJD. Histologically, there was neuronal loss with or without spongiform change in the cerebral cortex, parahippocampal gyrus, amygdala, striatum, pallidum, thalamus, pontine nucleus, and cerebellar granule cells, in addition to diffuse synaptic-type prion staining in the cerebrum and cerebellum. Furthermore, senile plaques, compatible with definite Consortium to establish a registry for Alzheimer's disease rank Alzheimer's disease, and neurofibrillary changes of the limbic system, consistent with stage IV of Braak's classification, were found. Based on these clinicopathological findings and a review of the published literature, it is concluded that there were two forms of coexistence of CJD and Alzheimer's disease in the same patient.
Tsuchiya
Kuniaki
K
Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan. ktsuchi@jcom.home.ne.jp
Yagishita
Saburo
S
Ikeda
Kenji
K
Sano
Michio
M
Taki
Kazuhiro
K
Hashimoto
Keisuke
K
Watabiki
Sadakiyo
S
Mizusawa
Hidehiro
H
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans