[Expression of macrophage colony stimulating factor in brains of PDAPPV717I transgenic mice].
OBJECTIVE
To identify the expression and distribution of macrophage colony stimulating factor (M-CSF) in brains of PDAPPV717I transgenic mice.


METHODS
We detected the expression and distribution of M-CSF mRNA in brains of PDAPPV717I transgenic mice by using hybridization in situ and immunohistochemical staining.


RESULTS
Expression of M-CSF mRNA was significantly higher in brains of PDAPPV717I transgenic mice than that in non-transgenic mice, and M-CSF mRNA in brain was mainly produced by reactive astrocytes.


CONCLUSIONS
The results indicate that astrocytes play an important role in the onset/development of neuropathology of Alzheimer's disease.
Zhang
Jian-min
JM
Department of Immunology, Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China.
Kong
Qing-li
QL
Wang
Hong
H
Qin
Chuan
C
He
Wei
W
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D012333:RNA, Messenger; D016173:Macrophage Colony-Stimulating Factor