Anticonvulsant hypersensitivity syndrome: treatment with corticosteroids and intravenous immunoglobulin.
We describe the case of a patient in whom anticonvulsant hypersensitivity syndrome developed during treatment with phenytoin and progressed when therapy was changed to phenobarbital. Although therapeutic options remain controversial, corticosteroids and IV immunoglobulin were used in our patient. The patient had a complete recovery, suggesting the potential benefit of corticosteroids and IV immunoglobulin for anticonvulsant hypersensitivity syndrome.
Mostella
Jenester
J
Department of Clinical Pharmacy, Druid City Hospital, USA.
Pieroni
Robert
R
Jones
Richard
R
Finch
Christopher K
CK
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008775:Methylprednisolone / Q000627:therapeutic use*; D010634:Phenobarbital / Q000009:adverse effects*; D010672:Phenytoin / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome
D000927:Anticonvulsants; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D010672:Phenytoin; D011241:Prednisone; D008775:Methylprednisolone; D010634:Phenobarbital