Atmospheric pressure as a force that fills developing bones with marrow and air.
Many theories try to explain the existence and function of paranasal sinuses. This paper is an attempt to correlate process of paranasal sinus development in human with bone pneumatization processes in animals. It is here proposed that this mechanism starts in utero and continues after birth. During endochondral development, a solid hyaline cartilage model transforms into long bones. Central chondrocytes hypertrophy and their lacunae become confluent. Dissolving of the cartilage intercellular matrix forms a primitive marrow cavity. It is soon invaded by the periostal bud. Once circulation is established in the developing bone, the dissolved hyaline matrix can be slowly washed away from the bone cavity. Circulation in the bone cavity can develop slight subatmospheric pressures, similar to negative interstitial pressures in subcutaneous tissues. The amniotic fluid conducts atmospheric pressure to the fetal body. The pressure is trying to fill enlarging bone cavities through the existing vascular openings, or to create new openings. Bone walls of developing paranasal bones are to weak to resist the pressure gradient on their walls. New openings form on the weakest spots allowing airway mucosa to form initial paranasal sinuses. The enlarging cavities of long bones that are remote from the body surface and airway also develop a slightly subatmospheric pressure that fills them with cellular elements. These elements enter bone through the feeding vessels and form bone marrow. During after birth skeletal growth, bone remodeling shapes paranasal sinuses in a process of slow evolution that do not require measurable pressure gradients. When two sinuses come in vicinity, their growth rate declines, since the remaining thin and fragile bone lamella between them does not retract anymore.
Kurbel
Sven
S
Osijek Medical Faculty, 4 J. Huttler Street, Osijek 31000, Croatia. sven.kurbel@public.srce.hr
Radić
Radivoje
R
Kristek
Branka
B
Ivezić
Zdravko
Z
Selthofer
Robert
R
Kotromanović
Zeljko
Z
D000818:Animals; D001274:Atmospheric Pressure; D001846:Bone Development / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology*; D016723:Bone Remodeling; D019902:Chondrocytes / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010256:Paranasal Sinuses / Q000196:embryology / Q000254:growth & development* / Q000502:physiology*; D014057:Tomography, X-Ray Computed