Synthesis and evaluation of HEMA-free glass-ionomer cements for dental applications.
OBJECTIVE
The objective of this study was to synthesize and characterize amino acid acrylate and methacrylate derivatives, use them to formulate light-cured glass-ionomer cements (LCGICs), and evaluate their mechanical strengths.


METHODS
Acrylate and methacrylate derivatives of six amino acids were synthesized and characterized using FT-IR and 1HNMR spectroscopy. The LCGICs were formulated using a newly synthesized polymer having pendant methacrylate groups (in other words, a methacryloyl derived polymer or MDP), amino acid derivatives, water, and Fuji II LC glass. Compressive strength of the cements and viscosities of the resin liquids were used as screening tools in order to determine the optimal formulation. The specimens were conditioned in distilled water at 37 degrees C for 24 h prior to testing.


RESULTS
The measured compressive strengths (MPa) of the cements were found to depend on the amino acid derivative used: acryloyl aspartic acid (268.5) > methacryloyl beta-alanine (259.1) = methacryloyl glutamic acid (254.5) = acryloyl beta-alanine (251.9) > acryloyl glutamic acid (238.8) > methacryloyl aspartic acid (210.9). Methacryloyl beta-alanine (MBA) was selected for further formulations due to its relatively low solution viscosity and high compressive strength. Effects of MDP content and power/liquid (P/L) ratio were significant. The formulation with a liquid composition of 50/25/25 (MDP/MBA/water) and P/L ratio of 2.7/1 was found to give optimal properties and handling of all the formulations studied.


CONCLUSIONS
A novel HEMA-free LCGIC system based on amino acid derivatives has been developed. This system may eliminate potential cytotoxicity in current LCGICs caused by leached 2-hydroxyethyl methacrylate (HEMA). The optimal MBA-modified cements were 20% higher in compressive strength, 70% higher in diametral tensile strength (DTS) and 93% higher in flexure strength (FS), as compared to Fuji II LC cement.
Xie
Dong
D
Department of Biomedical Engineering, The University of Alabama at Birmingham, 370 Hoehn Engineering Building, 1075 13th Street South, Birmingham, AL 35294, USA. dxie@eng.uab.edu
Chung
Il-Doo
ID
Wu
Wei
W
Mays
Jimmy
J
D000596:Amino Acids / Q000737:chemistry; D000704:Analysis of Variance; D019245:Compressive Strength; D003799:Dental Stress Analysis; D004548:Elasticity; D005899:Glass Ionomer Cements / Q000138:chemical synthesis* / Q000737:chemistry* / Q000528:radiation effects; D008027:Light; D008422:Materials Testing; D008689:Methacrylates / Q000737:chemistry* / Q000633:toxicity; D015394:Molecular Structure; D018583:Pliability; D017550:Spectroscopy, Fourier Transform Infrared; D018709:Statistics, Nonparametric; D013718:Tensile Strength; D014783:Viscosity
D000596:Amino Acids; D005899:Glass Ionomer Cements; D008689:Methacrylates; C005044:hydroxyethyl methacrylate