Synthesis and biochemical properties of E-ring modified luotonin A derivatives.
Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.
Cagir
Ali
A
Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22901, USA.
Jones
Shannon H
SH
Eisenhauer
Brian M
BM
Gao
Rong
R
Hecht
Sidney M
SM
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry* / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors
D004791:Enzyme Inhibitors; D011758:Pyrroles; D011809:Quinones; D059004:Topoisomerase I Inhibitors; C480761:luotonin A