title: New derivatives of quinazoline and 1, 2-dihydroquinazoline n3-oxide with expected antitumor activity.
abstract: Some derivatives of quinazoline and 1, 2-dihydroquinazoline N(3)-oxide were synthesised and their cytotoxic activities against human leukaemia HL-60 cells under hypoxic and aerobic conditions were tested and compared to tirapazamine as the reference compound. Compound 8 showed 5-fold higher toxicity under hypoxic conditions than in normal oxygen atmosphere. The structure of quinazoline derivatives was established by X-ray crystal structure analysis.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Analysis, Medical University, Łódź, Poland. eolasik@farm.pharm.am.lodz.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Mikiciuk-Olasik
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Baszczak-Swiatkiewiz
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Zurek
authors.forename: Urszula
authors.initials: U
authors.lastname: Krajewska
authors.forename: Marek
authors.initials: M
authors.lastname: Rózalski
authors.forename: Rafał
authors.initials: R
authors.lastname: Kruszyński
authors.forename: Tadeusz J
authors.initials: TJ
authors.lastname: Bartczak
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015687:Cell Hypoxia; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C487730:1, 2-dihydroquinazoline N3-oxide; D000970:Antineoplastic Agents; D011799:Quinazolines