Antibodies to microtubule-associated protein 2 in patients with neuropsychiatric systemic lupus erythematosus.
OBJECTIVE
Microtubule-associated protein 2 (MAP-2), a cellular protein restricted to neurons, is important in the control of cytoskeletal integrity and other neuronal functions. We undertook this study to examine the presence of autoantibodies to MAP-2 in neuropsychiatric systemic lupus erythematosus (NPSLE).


METHODS
Sera from 100 patients with SLE, 74 patients with other neurologic disorders and injuries (including cerebrovascular accidents, brain trauma, brain tumors, and demyelinating disorders), and 60 normal controls were examined both by enzyme immunoassays and by Western immunoblotting for autoantibodies to MAP-2. Sera designated positive for antibodies to MAP-2 were required to be positive in both assays.


RESULTS
Seventeen percent of SLE patients had autoantibodies to MAP-2, in contrast to 4% of neurologic injury/disease control patients (P = 0.028) and 1.7% of normal controls. In SLE, anti-MAP-2 positivity in both assays was associated with neuropsychiatric symptoms in 76.5% of patients, whereas the absence of anti-MAP-2 was associated with neuropsychiatric symptoms in 19.7% of patients (P = 0.0002). The neuropsychiatric symptoms in the former group included psychosis, seizure, neuropathy, and cerebritis.


CONCLUSIONS
Autoantibodies to MAP-2, a neuron-restricted cytoskeletal protein, appear to be another immune marker for NPSLE.
Williams
Ralph C
RC
University of New Mexico School of Medicine, Albuquerque, USA.
Sugiura
Kazumitsu
K
Tan
Eng M
EM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D001930:Brain Injuries / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D020945:Lupus Vasculitis, Central Nervous System / Q000276:immunology*; D008297:Male; D008869:Microtubule-Associated Proteins / Q000276:immunology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000276:immunology; D009474:Neurons / Q000276:immunology; D013119:Spinal Cord Injuries / Q000276:immunology
D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D008869:Microtubule-Associated Proteins