title: Development of 99mTc labelled Lipiodol: biodistribution following injection into the hepatic artery of the healthy pig.
abstract: BACKGROUND
  We develop a method for the radiolabelling of Lipiodol with Tc, using a lipophilic complex, [99mTc-(S2CPh)(S3Ph)2], dissolved in Lipiodol (99mTc-SSS Lipiodol).
  
  
  RESULTS
  The labelling yield is high (96 +/- 0.8%), and the radiochemical purity satisfactory (92 +/- 2.6%). This labelling is reproducible and stable for up to 24 h in vitro. Studies carried out after injection into the hepatic artery of the healthy pig show that the biodistribution of 99mTc-SSS Lipiodol is comparable with that observed for 188Re Lipiodol.
  
  
  METHODS
  The 99mTc-SSS lipiodol was obtained after dissolving a chelating agent, previously labelled with 99mTc, in cold lipiodol. The radiochemical purity (RCP) of the labelling was checked immediately and at 24 h. The 99mTc-SSS lipiodol was injected into the hepatic artery of four healthy pigs for an ex-vivo biodistribution study. An autoradiographic study was performed in two cases.
  
  
  CONCLUSIONS
  Apart from the specific interest of a Lipiodol-bearing technetiated agent for carrying out dosimetric studies, the labelling of Lipiodol with 99mTc is a preliminary step towards the use of radiolabelling with the 188Re analogue.
authors.affiliation: Service de Médecine Nucléaire, Centre Eugène Marquis, Rennes, France. etienne.garin@univ-rennes1.fr
authors.forename: Etienne
authors.initials: E
authors.lastname: Garin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Noiret
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Malbert
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lepareur
authors.forename: Alain
authors.initials: A
authors.lastname: Roucoux
authors.forename: Léontine
authors.initials: L
authors.lastname: Dazord
authors.forename: Sylvie
authors.initials: S
authors.lastname: Caulet-Maugendre
authors.forename: Bruno
authors.initials: B
authors.lastname: Turlin
authors.forename: Annick
authors.initials: A
authors.lastname: Moisan
authors.forename: Joseph
authors.initials: J
authors.lastname: Lecloirec
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Herry
authors.forename: Eveline
authors.initials: E
authors.lastname: Boucher
authors.forename: Jean-Lue
authors.initials: JL
authors.lastname: Raoul
authors.forename: Patrick
authors.initials: P
authors.lastname: Bourguet
mesh_terms: D000818:Animals; D005240:Feasibility Studies; D006499:Hepatic Artery / Q000187:drug effects / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000737:chemistry* / Q000493:pharmacokinetics*; D007553:Isotope Labeling / Q000379:methods*; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013552:Swine; D013667:Technetium / Q000737:chemistry* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium; D007459:Iodized Oil