title: Ross and Ross-Konno procedure in children and adolescents: mid-term results.
abstract: OBJECTIVE
  The aim of the study was to analyze mid-term results of aortic root replacement with pulmonary autograft in children and adolescents in two centers.
  
  
  METHODS
  From December 1997 through August 2003, a total of 66 patients underwent the Ross procedure in two centers. Indication for Ross procedure was predominantly aortic stenosis in 24 patients and predominantly aortic regurgitation (AR) in 22 patients. Twenty patients with severe left ventricular outflow tract obstruction (LVOTO) underwent Ross-Konno procedure. No patient had a geometric mismatch of more than 5 mm in favor of the aortic annulus.
  
  
  RESULTS
  There was no early death. One patient died 3 months after surgery due to bacterial endocarditis. Survival on median follow-up period of 2.4 years was 98.5%. Neo-aortic regurgitation was none in 29 (44%) patients, trivial in 35 (53%) patients and mild in 2 (3%) patients. One patient (1.5%) needed aortic valve replacement because of autograft failure. Actuarial freedom from more than trivial neo-aortic regurgitation, or aortic valve replacement was 95% at 5 years follow-up. There was no patient either with recurrent LVOTO or significant aortic root dilatation. Freedom from redo was 93% at 5 years of follow-up. There had been a significant reduction (P = 0.001) and normalization in the left ventricle diastolic diameter index and left ventricle mass index, respectively, within 3-12 months after operation. Sixty-three percent of all operated patients are without medication; no one is on anticoagulation therapy.
  
  
  CONCLUSIONS
  Our 7 years experience with the Ross and Ross-Konno operation has shown excellent mid-term results, with mortality rate approaching zero in both simple and complex left heart lesions, even in the neonates and infants. It is a procedure of choice in children with severe anomaly of the aortic valve and/or left ventricular outflow tract obstruction. The main concern is dilatation of the neo-aortic root leading to progression of AR, especially in the settings of geometric mismatch of aortic and pulmonary roots and bicuspid, regurgitant aortic valve. The risk of autograft failure in these specific subsets of patients remains to be determined.
authors.affiliation: Department of Pediatric Cardiac Surgery, University Hospital Hamburg-Eppendorf, Martinistrase 52, 20246 Hamburg, Germany. v.hraska@uke.uni-hamburg.de
authors.forename: V
authors.initials: V
authors.lastname: Hraska
authors.forename: M
authors.initials: M
authors.lastname: Krajci
authors.forename: Ch
authors.initials: Ch
authors.lastname: Haun
authors.forename: K
authors.initials: K
authors.lastname: Ntalakoura
authors.forename: V
authors.initials: V
authors.lastname: Razek
authors.forename: F
authors.initials: F
authors.lastname: Lacour-Gayet
authors.forename: J
authors.initials: J
authors.lastname: Weil
authors.forename: H
authors.initials: H
authors.lastname: Reichenspurner
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001022:Aortic Valve Insufficiency / Q000151:congenital / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000151:congenital / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005500:Follow-Up Studies; D006084:Graft Rejection; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011664:Pulmonary Valve / Q000637:transplantation*; D016896:Treatment Outcome; D014694:Ventricular Outflow Obstruction / Q000601:surgery