Differential desensitization of somatostatin receptor subtypes in atT-20 cells.
Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.
Mazza
Fredric C
FC
Department of Biology, Seton Hall University, South Orange, NJ 07079, USA.
Blake
Allan D
AD
D000818:Animals; D045744:Cell Line, Tumor; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D051379:Mice; D017481:Receptors, Somatostatin / Q000819:agonists / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism*
D017481:Receptors, Somatostatin; D005576:Colforsin; D013004:Somatostatin; D000242:Cyclic AMP