title: Glass microchip with three-dimensional microchannel network for 2 x 2 parallel synthesis.
abstract: An integrated multireactor system for 2 x 2 parallel organic synthesis has been developed on a single glass microchip. Three-dimensional channel circuits in the chip were fabricated by laminating three glass plate layers. The fabrication method is a straightforward extension of the conventional one, and topological equivalence for any three-dimensional circuits can be constructed easily with it. 2 x 2 phase-transfer amide formation reactions, which constitute a simple model for combinatorial synthesis, were successfully carried out on the microchip, and the integrity of the three-dimensional circuits was confirmed. Combinatorial chemistry with multi-microreactors, in conjunction with a high-throughput screening method based on micro-TAS technologies, is expected to provide an efficient tool for drug discovery.
authors.affiliation: Integrated Chemistry Project, Kanagawa Academy of Science and Technology (KAST), Kanagawa, Japan.
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Kikutani
authors.forename: Takayuki
authors.initials: T
authors.lastname: Horiuchi
authors.forename: Kenji
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hisamoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Tokeshi
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kitamori