title: DNA-templated Ag nanocluster formation.
abstract: The high affinity of Ag+ for DNA bases has enabled creation of short oligonucleotide-encapsulated Ag nanoclusters without formation of large nanoparticles. Time-dependent formation of cluster sizes ranging from Ag1 to Ag4/oligonucleotide were observed with strong, characteristic electronic transitions between 400 and 600 nm. The slow nanocluster formation kinetics enables observation of specific aqueous nanocluster absorptions that evolve over a period of 12 h. Induced circular dichroism bands confirm that the nanoclusters are associated with the chiral ss-DNA template. Fluorescence, absorption, mass, and NMR spectra all indicate that multiple species are present, but that their creation is both nucleotide- and time-dependent.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400 USA. jeff.petty@furman.edu
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Petty
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Nicholas V
authors.initials: NV
authors.lastname: Hud
authors.forename: Robert M
authors.initials: RM
authors.lastname: Dickson
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013698:Templates, Genetic
chemical_list: D009841:Oligonucleotides; D012834:Silver; D004247:DNA