Vitamin A supplementation and risk of skeletal fracture.
Effects of toxic amounts of vitamin A include skeletal effects; from acute toxic exposure to chronic high-dose intake of vitamin A, these effects have led experts to speculate that long-term consumption of diets high in vitamin A (retinol) stimulates bone resorption and inhibits bone formation, and may contribute to osteoporosis and hip fractures.
Genaro
Patrićia de Souza
Pde S
Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo, Av Dr Arnaldo, 715, Cep 01246-904, São Paulo, Brazil.
Martini
Lígia Araújo
LA
D000818:Animals; D001862:Bone Resorption; D019587:Dietary Supplements / Q000009:adverse effects*; D005260:Female; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications*; D008297:Male; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects*
D014801:Vitamin A