title: Further studies on the antihepatotoxic activity of Phyllanthus maderaspatensis Linn.
abstract: Phyllanthus maderaspatensis (whole plant extracts) was evaluated for its antihepatotoxic and choleretic activities in rats. The plant extracts (200 mg/kg, n-hexane, ethyl alcohol or water) showed a remarkable hepatoprotective activity against acetaminophen-induced hepatotoxicity as judged from the serum marker enzymes. The water and ethyl alcohol extracts showed moderate activity compared to the n-hexane extract, which showed activity at a dose as low as 1.5 mg/kg. The antihepatotoxicity of the hexane extract was found to be better than silymarin, a standard hepatoprotective herbal drug. The effect of n-hexane extract was found to be concentration-dependent. This extract also exhibited choleretic activity in normal rats, and in vitro hydroxyl radical scavenging activity and inhibition of lipid peroxidation.
authors.affiliation: Molecular Ethnopharmacology, Rajiv Gandhi Centre for Biotechnology, Kerala, India. ashavv@rediffmail.com
authors.forename: V V
authors.initials: VV
authors.lastname: Asha
authors.forename: S
authors.initials: S
authors.lastname: Akhila
authors.forename: P J
authors.initials: PJ
authors.lastname: Wills
authors.forename: A
authors.initials: A
authors.lastname: Subramoniam
mesh_terms: D000082:Acetaminophen; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016166:Free Radical Scavengers; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen