title: Destructive arthritis in a patient with Haim-munk syndrome.
abstract: Haim-Munk and Papillon-Lefèvre are 2 closely related syndromes, inherited in an autosomal recessive pattern, manifested by palmoplantar keratoderma and early, destructive periodontitis. Recently, mutations in the cathepsin C gene have been recognized in both syndromes. We describe a patient with Haim-Munk syndrome (palmar plantar keratosis and periodontitis) and destructive arthritis of the wrists and shoulder joints, an association that has not been previously described.
authors.affiliation: Department of Medicine B and Rheumatology Unit, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel.
authors.forename: Merav
authors.initials: M
authors.lastname: Lidar
authors.forename: Abraham
authors.initials: A
authors.lastname: Zlotogorski
authors.forename: Pnina
authors.initials: P
authors.lastname: Langevitz
authors.forename: Nurit
authors.initials: N
authors.lastname: Tweezer-Zaks
authors.forename: Gisele
authors.initials: G
authors.lastname: Zandman-Goddard
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001168:Arthritis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D001175:Arthrography; D005260:Female; D005385:Fingers / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010518:Periodontitis / Q000473:pathology*; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000473:pathology; D013577:Syndrome; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal