[Effect of hyperlipidemia on pharmacodynamics of propranolol and atenolol].
The study was aimed to examine the effects of different presentations of hyperlipidemia on the pharmacodynamics of lipophilic propranolol and hydrophilic atenolol. Thirty subjects were divided into four study groups: the normolipemic subjects, patients with hypercholesterolemia, hypertriglyceridemia and patients with mixed form of hyperlipidemia. The drugs were administered orally at a single dose of 80 mg propranolol and 100 mg atenolol, using a cross-over study design. The plasma concentrations of propranolol and atenolol were determined using high-performance liquid chromatography (HPLC). Heart rate as well as systolic and diastolic blood pressure were evaluated in relation to the serum drug concentrations. In the light of the results obtained, the following conclusions were drawn: 1) hyperlipidemia affects pharmacodynamic properties of lipophilic propranolol and hydrophilic atenolol, 2) a modification of the drug dosage in hyperlipidemia is warranted.
Telatyńska-Smieszek
Bogumiła
B
Klinika Nefrologii, Transplantologii i Chorób Wewnetrznych Pomorskiej AM w Szczecinie.
Wójcicki
Jerzy
J
Droździk
Marek
M
Gawrońska-Szklarz
Barbara
B
Sulzyc-Bielicka
Violetta
V
Sterna
Rozalia
R
D000284:Administration, Oral; D000319:Adrenergic beta-Antagonists / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D019540:Area Under Curve; D001262:Atenolol / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D005260:Female; D006207:Half-Life; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D006949:Hyperlipidemias / Q000097:blood*; D015228:Hypertriglyceridemia / Q000097:blood; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology; D013997:Time Factors; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D011433:Propranolol