title: Spinal anesthesia with bupivacaine decreases cerebral blood flow in former preterm infants.
abstract: Spinal anesthesia is commonly used in former preterm infants (FPI). In these patients, hypotension induced by spinal anesthesia may impair cerebral blood flow. We measured cerebral blood flow velocity (CBFV) by transcranial Doppler ultrasound to assess the effect of hypotension induced by spinal anesthesia on cerebral hemodynamics. Twelve FPI scheduled for inguinal hernia repair were operated under spinal anesthesia using 1 mg/kg isobaric 0.5% bupivacaine. Systolic, diastolic, and mean middle cerebral artery CBFV were measured at 5 min before and 5 min and 10 min after spinal anesthesia using a transcranial pulsed Doppler ultrasonography. Arterial blood pressure and heart rate were recorded simultaneously. Cerebral arteries resistance index (RI) was calculated as RI = (peak systolic CBFV - end-diastolic CBFV)/peak systolic CBFV. Diastolic CBFV decreased significantly from 30.0 +/- 11.1 cm/s to 20.1 +/- 8.4 cm/s at 5 min and to 20.1 +/- 7.0 cm/s at 10 min. RI increased significantly from 0.7 +/- 0.1 to 0.8 +/- 0.1 at 5 min and 10 min. Systolic, diastolic, and mean arterial blood pressures decreased significantly at the same time intervals. We suggest that in FPI, spinal anesthesia induces a decrease in cerebral blood flow related to changes in arterial blood pressure. Whether these changes have deleterious consequences remains to be determined.
  
  
  CONCLUSIONS
  In former preterm infants having spinal anesthesia with bupivacaine, a decrease in cerebral blood flow velocity is displayed by middle cerebral artery transcranial Doppler examination.
authors.affiliation: Département d'Anesthésie Réanimation, Centre Hospitalo-Universitaire de Bicêtre, Kremlin Bicêtre, France. mariepierre.bonnet@9online.fr
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Bonnet
authors.forename: Eric
authors.initials: E
authors.lastname: Larousse
authors.forename: Karim
authors.initials: K
authors.lastname: Asehnoune
authors.forename: Dan
authors.initials: D
authors.lastname: Benhamou
mesh_terms: D000775:Anesthesia, Spinal; D000779:Anesthetics, Local; D001794:Blood Pressure / Q000502:physiology; D002045:Bupivacaine; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D011446:Prospective Studies; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine