Treatment of Hailey-Hailey disease with tacrolimus ointment and clobetasol propionate foam.
Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known cure. Current therapeutic strategies attempt to suppress Hailey-Hailey outbreaks and allow the patient to live comfortably with this condition. We have found that applying topical tacrolimus 0.1% ointment (Protopic) twice a day to affected areas is an excellent way to control Hailey-Hailey disease. In addition to effectively controlling Hailey-Hailey outbreaks, tacrolimus is a relatively safe and noninvasive mode of treatment, without significant side effects. We recommend intermittent therapy with clobetasol propionate 0.05% foam (Olux Foam) for patients who break through suppressive therapy with tacrolimus a few times per year. In patients with frequent outbreaks of Hailey-Hailey disease despite suppressive therapy with tacrolimus, we recommend alternating the tacrolimus with clobetasol propionate 0.05% foam every 6 weeks.
Umar
Saleem A
SA
Forum Health, Youngstown, OH, USA.
Bhattacharjee
Pradip
P
Brodell
Robert T
RT
D002990:Clobetasol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000188:drug therapy* / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D002990:Clobetasol; D016559:Tacrolimus