Correlation of immunohistochemically detected HER-2/neu (c-erbB-2) with histological stage and perineural invasion in pancreatic cancer.
OBJECTIVE
HER-2/neu (c-erbB-2) oncoprotein is a transmembrane glycoprotein and may function as a growth factor being involved in the regulation of cell growth and cell transformation. c-erbB-2 was correlated with established outcome factors in pancreatic cancer.


METHODS
We performed an analysis of 100 patients with pancreatic cancer using an immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue samples in order to determine HER-2/neu oncoprotein expression along with stage and perineural involvement.


RESULTS
HER-2/neu oncoprotein was expressed in the tumors of 21 patients (21%).


CONCLUSIONS
Histologic stage, and perineural invasion did not correlate with HER-2/neu oncoprotein.
Tamiolakis
D
D
Department of Cytology, General Hospital of Chania, Crete, Greece.
Venizelos
I
I
Simopoulos
C
C
Kotini
A
A
Jivannakis
T
T
Papadopoulos
N
N
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010446:Peptide Fragments / Q000378:metabolism*; D010502:Perineum / Q000473:pathology*
C445779:HER-2-derived peptide 884-899; D010446:Peptide Fragments