Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains.
Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.
Papenfuss
Tracey L
TL
Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, 2078 Graves Hall, 333 West 10th Ave., Columbus, OH 43210-1239, USA. pappenfuss.1@osu.edu
Rogers
Connie J
CJ
Gienapp
Ingrid
I
Yurrita
Maria
M
McClain
Melanie
M
Damico
Nicole
N
Valo
Janie
J
Song
Fei
F
Whitacre
Caroline C
CC
D000595:Amino Acid Sequence; D000818:Animals; D002369:Castration; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D015994:Incidence; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D010052:Ovariectomy; D012720:Severity of Illness Index; D012727:Sex Characteristics; D013045:Species Specificity