title: LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.
abstract: In a previous study, we isolated a novel gene, LRRC8 (leucine-rich repeat-containing 8), in a girl with congenital agammaglobulinemia. We have now identified four unknown LRRC8-like genes, named TA-LRRP, AD158, LRRC5, and FLJ23420. Their predicted structures are very similar to each other, and highly conserved between humans and the mouse. All five genes encode proteins consisting of 16 extracellular leucine-rich repeats (LRRs), all of which have four transmembrane regions except for FLJ23420. These genes belong to a novel family, designated the LRRC8 family, within the superfamily of LRR proteins. TA-LRRP, AD158, and LRRC5 might be implicated in proliferation and activation of lymphocytes and monocytes.
authors.affiliation: Department of Developmental Medicine (Pediatrics), Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan. keikubo@ped.med.osaka-u.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Kubota
authors.forename: Ji Yoo
authors.initials: JY
authors.lastname: Kim
authors.forename: Akihisa
authors.initials: A
authors.lastname: Sawada
authors.forename: Sadao
authors.initials: S
authors.lastname: Tokimasa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujisaki
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Matsuda-Hashii
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ozono
authors.forename: Junichi
authors.initials: J
authors.lastname: Hara
mesh_terms: D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000737:chemistry* / Q000166:cytology; D001923:Brain Chemistry; D030541:Databases, Genetic; D019143:Evolution, Molecular; D006801:Humans; D000090263:Leucine-Rich Repeat Proteins; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D005810:Multigene Family; D010920:Placenta / Q000737:chemistry; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D040681:Structural Homology, Protein; D014018:Tissue Distribution
chemical_list: C485976:LRRC8A protein, human; D000090263:Leucine-Rich Repeat Proteins; D008565:Membrane Proteins; D011506:Proteins; D012333:RNA, Messenger