Preserved episodic memory in subcortical band heterotopia.
OBJECTIVE
Neuropsychological profiles of four patients with subcortical band heterotopia (SBH) are presented to delineate further the phenotype of this disorder.


METHODS
Standardized, norm-referenced measures of cognitive functioning, including intelligence, processing speed, attention, language, visuomotor skills, memory, and fine motor ability were administered to four patients with magnetic resonance imaging evidence of SBH.


RESULTS
Despite intellectual impairment and other severe cognitive deficits, all four patients displayed relatively intact episodic memory.


CONCLUSIONS
This selective sparing of memory functions has not been previously reported in individuals with SBH and suggests that doublecortin does not play a role in the development of memory systems in the mesial temporal region, which tend to be spared in SBH.
Janzen
Laura
L
Department of Clinical Neurosciences, London Health Sciences Center, London, Ontario, Canada. Laura.Janzen@lhsc.on.ca
Sherman
Elisabeth
E
Langfitt
John
J
Berg
Michel
M
Connolly
Mary
M
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000002:abnormalities*; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D000089622:Doublecortin Domain Proteins; D004569:Electroencephalography / Q000706:statistics & numerical data; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000523:psychology; D004827:Epilepsy / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000523:psychology; D008869:Microtubule-Associated Proteins; D009421:Nervous System Malformations / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D009479:Neuropeptides / Q000235:genetics; D009483:Neuropsychological Tests; D013702:Temporal Lobe / Q000503:physiopathology; D014888:Wechsler Scales
D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides