title: Expression of c-Fos and NADPH-d after peripheral noxious stimulation in the pedunculopontine tegmental nucleus.
abstract: The participation of pedunculopontine tegmental nucleus in descending pain control mechanisms has been proposed. The aim of this study was to investigate NADPH-d and c-Fos reactivity in the pedunculopontine tegmental nucleus following noxious peripheral stimulation. Formalin induced hind paw inflammation in the rat resulted in bilateral increase of Fos and NADPH-d expression in the pedunculopontine tegmental nucleus. Approximately 30% of labelled cells were double-labelled. Close proximity to NADPH-d labelled neuronal processes with Fos-labelled nuclei were observed. This anatomical relationship supports the hypothesis that pedunculopontine tegmental nucleus is involved in pain modulation and proposes a new explanation for the presence of nitric oxide in this nucleus.
authors.affiliation: Department of Anatomy, Ege University Faculty of Medicine, Bornova, Izmir, Turkey. kayali@rocketmail.com
authors.forename: Gulgun
authors.initials: G
authors.lastname: Kayalioglu
authors.forename: Burcu
authors.initials: B
authors.lastname: Balkan
mesh_terms: D000818:Animals; D005557:Formaldehyde; D016762:Genes, fos / Q000235:genetics*; D007150:Immunohistochemistry; D008297:Male; D008636:Mesencephalon / Q000378:metabolism*; D009252:NADPH Dehydrogenase / Q000096:biosynthesis* / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology*; D010146:Pain / Q000139:chemically induced / Q000378:metabolism*; D010812:Physical Stimulation; D011149:Pons / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013681:Tegmentum Mesencephali / Q000378:metabolism*
chemical_list: D005557:Formaldehyde; D009569:Nitric Oxide; D009252:NADPH Dehydrogenase