Prevalence of beta2-glycoprotein I antibody in patients with liver cirrhosis: relationship with beta2-glycoprotein I plasma levels and thrombosis.
Recently, a semiquantitative enzyme-linked immunoassay for detecting IgG or IgM class autoantibody to beta2-GPI for use as an aid in the diagnosis of certain autoimmune or thrombotic disorders. We evaluated the prevalence of anti-beta2-GPI antibody and its relation to plasma beta2-GPI levels and occurrence of thrombosis in 69 patients with liver cirrhosis. As expected, plasma beta2-GPI levels were lower in the patients with liver cirrhosis and correlated with Child classification. Anti-beta2-GPI antibodies were positive in 11 (15.9%) patients. However, there were no differences in beta2-GPI levels, platelet counts, and thrombosis between positive and negative groups for anti-beta2-GPI antibodies.
Song
Kyung Soon
KS
Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. kssong@yumc.yonsei.ac.kr
Kim
Hyun Kyung
HK
D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology*; D005260:Female; D006023:Glycoproteins / Q000097:blood* / Q000276:immunology*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D015995:Prevalence; D013927:Thrombosis / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D053482:beta 2-Glycoprotein I
D001323:Autoantibodies; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I