title: Histopathologic difference between chronic pancreatitis animal models and human chronic pancreatitis.
abstract: OBJECTIVE
  There are many experimental models for chronic pancreatitis. However, it remains unclear which animal models of pancreatic fibrosis can be categorized as chronic pancreatitis models. We compared the histologic features of some animal models of pancreatic fibrosis/chronic pancreatitis and chronic pancreatitis in humans.
  
  
  RESULTS
  Human chronic pancreatitis due to chronic alcohol abuse and unknown etiology showed interlobular fibrosis and a cirrhosis-like appearance. Histopathologically, spontaneous pancreatitis models, WBN/Kob rats and OLETF rats, showed localized/nodular fibrotic lesions, which consisted of swollen, aggregated, atrophic islets of Langerhans; loss of the exocrine parenchyma and hemosiderin deposition that was seldom distributed in the interlobular area. On the other hand, fibrosis in the canine model, which was produced by combining alcohol administration with incomplete pancreatic duct obstruction, was characterized by interlobular fibrosis admixed with a cirrhosis-like appearance very similar to that in human chronic pancreatitis.
  
  
  CONCLUSIONS
  Most experimental models for chronic pancreatitis, except alcohol administration combined with other procedures such as incomplete pancreatic duct obstruction, are different from human chronic pancreatitis.
authors.affiliation: Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan. ksuda@med.juntendo.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Suda
authors.forename: Masaru
authors.initials: M
authors.lastname: Takase
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fukumura
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Suzuki
authors.forename: Atsuro
authors.initials: A
authors.lastname: Jim
authors.forename: Chihaya
authors.initials: C
authors.lastname: Kakinuma
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsugu
authors.forename: Kyoko
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Funakoshi
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000473:pathology*; D051381:Rats; D020334:Rats, Inbred OLETF; D013045:Species Specificity