title: Postoperative complications following gastrectomy for gastric cancer during the last decade.
abstract: OBJECTIVE
  The reduction in the incidence of severe postoperative complications has resulted in a significant increase in the survival of patients with gastric cancer.
  
  
  METHODS
  A total of 879 patients undergoing gastrectomy for gastric cancer during the last decade were retrospectively evaluated for postoperative complications, mortality and associated risk factors.
  
  
  RESULTS
  The most frequent complications were anastomotic leakage (3.0%) and wound infection (2.8%) followed by the development of pancreatic fistulae (2.2%) and intra-abdominal abscesses (1.5%). Multiple logistic regression analysis identified various independent risk factors including the extent of lymph node dissection (D1D2 vs. D3) for anastomotic leakage (RR 3.6, P<0.05), splenectomy or distal pancreatosplenectomy for pancreatic fistulae (RR 27.4, P<0.0001) and operative time (360 min < or =) for intra-abdominal abscess (RR 4.8, P<0.05). In total, fourteen patients (1.6%, n=879) died from postoperative complications, with 5 patients dying following non-curative gastrectomy (5.6%, n=90). The complications most associated with death were anastomotic leakage (4 patients) and pneumonia (2 patients).
  
  
  CONCLUSIONS
  In view of the potential risk of complications, we should carefully evaluate the indications for aggressive lymph node dissection and/or combined resection of neighboring organs as well as non-curative gastrectomy.
authors.affiliation: Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan. ichikawa@koto.kpu-m.ac.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kurioka
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koike
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
authors.forename: Koichi
authors.initials: K
authors.lastname: Shirono
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shioaki
authors.forename: Eito
authors.initials: E
authors.lastname: Ikeda
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Mutoh
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000714:Anastomosis, Surgical; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010185:Pancreatic Fistula / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000601:surgery*; D013530:Surgical Wound Infection / Q000453:epidemiology