title: Efficacy of steroid therapy for pacing failure in a patient with chronic myocarditis.
abstract: A 66-year-old man had a progressive increase in the pacing threshold over a one-year period, resulting from chronic myocarditis. Following steroid therapy, the pacing threshold decreased and became stabilized, and was accompanied by a decrease in the serum creatine kinase, cardiac myosin light chains and pro-collagen III peptide values, but cardiac function did not improve. Endocardial biopsy showed that there was no progression in the fibrosis. The pacing failure improved, but the cardiac function did not. It was believed that the steroid therapy suppressed the progression of the inflammation and fibrosis caused by the chronic myocarditis.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Mitsuya
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kishi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Masachika
authors.initials: M
authors.lastname: Tamura
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Imai
authors.forename: Osamu
authors.initials: O
authors.lastname: Tanaka
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takagi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Miyake
authors.forename: Sachihiko
authors.initials: S
authors.lastname: Nobuoka
authors.forename: Jyunki
authors.initials: J
authors.lastname: Koike
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial; D002908:Chronic Disease; D003402:Creatine Kinase / Q000097:blood; D018450:Disease Progression; D005355:Fibrosis; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D009205:Myocarditis / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D010446:Peptide Fragments / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011347:Procollagen / Q000097:blood; D012804:Sick Sinus Syndrome / Q000188:drug therapy / Q000209:etiology*; D017211:Treatment Failure; D016277:Ventricular Function, Left
chemical_list: D005938:Glucocorticoids; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D011239:Prednisolone; D003402:Creatine Kinase; D008775:Methylprednisolone