QSAR study on phenolic activity: need of positive hydrophobic term (log P) in QSAR.
The phenolic activity (log 1/C) of a large series of phenols against L1210 leukaemia cells was modelled using physicochemical parameters other than conventional electronic and steric parameters. Attempts have also been made to examine need or otherwise of the hydrophobic parameter, log P, in such studies. The results have shown that contribution of log P in modelling log 1/C is favourable.
Thakur
Mamta
M
Department of Chemistry, Soft Vision College of Biotechnology and Science, 7, Green pank Colony, Indore 452001, India.
Agarwal
Alok
A
Thakur
Abhilash
A
Khadikar
Padmakar V
PV
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000473:pathology; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
D010636:Phenols