title: Treatment of endometrial hyperplasia with a danazol-releasing intrauterine device: a prospective study.
abstract: The purpose of the present study was to assess the effect of a danazol-releasing intrauterine device (D-IUD) in the treatment of endometrial hyperplasia. Twenty patients with endometrial hyperplasia including 14 with simple endometrial hyperplasia and 2 with complex endometrial hyperplasia (group A), and 4 with atypical endometrial hyperplasia (group B) were enrolled in the prospective study between August 1999 and December 2003. During and just after the treatment, improvement was seen in all patients. Simple or complex endometrial hyperplasia (group A) demonstrated regression to a normal secretory endometrium (38% of group A), pseudodecidual stromal change (31%) and glandular atrophy (25%), and miscellaneous change (inflammation, necrosis, etc.) (38%). Atypical hyperplasia (group B) demonstrated regression to a normal secretory endometrium (25% of group B), pseudodecidual stromal change (75%), glandular atrophy (50%) and miscellaneous change (granulation) (25%). In group A, 2 women conceived after completion of the treatment. The recurrence rate in patients with endometrial hyperplasia (groups A and B) in the follow- up was 20% and acceptable as compared with other studies. The pretreatment menstrual interval patterns of the patients were maintained peri- and post-treatment. These data indicate that D-IUD therapy might be a novel and effective method for the treatment of endometrial hyperplasia.
authors.affiliation: Department of Obstetrics and Gynecology, Saiseikai Central Hospital, Tokyo, Japan. yukoku@mac.com
authors.forename: Yukoku
authors.initials: Y
authors.lastname: Tamaoka
authors.forename: Hideki
authors.initials: H
authors.lastname: Orikasa
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sumi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Sakakura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kamei
authors.forename: Midori
authors.initials: M
authors.lastname: Nagatani
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ezawa
mesh_terms: D000328:Adult; D003613:Danazol / Q000008:administration & dosage*; D004714:Endometrial Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D004965:Estrogen Antagonists / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008598:Menstruation; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D014599:Uterus / Q000187:drug effects
chemical_list: D004965:Estrogen Antagonists; D003613:Danazol