title: G protein-coupled receptors in drug discovery.
abstract: G protein-coupled receptors (GPCRs) represent one of the most important drug discovery targets such that compounds targeted against GPCRs represent the single largest drug class currently on the market. With the revolutionary advances in human genome sciences and the identification of numerous orphan GPCRs, it is even more important to identify ligands for these orphan GPCRs so that their physiological and pathological roles can be delineated. To this end, major pharmaceutical industries are investing enormous amounts of time and money to achieve this object. This review is a bird's eye view on the various aspects of GPCRs in drug discovery.
authors.affiliation: Cardiovascular and Metabolic Diseases, Wyeth Research, Collegeville, Pennsylvania, USA. nambip@wyeth.com
authors.forename: Ponnal
authors.initials: P
authors.lastname: Nambi
authors.forename: Nambi
authors.initials: N
authors.lastname: Aiyar
mesh_terms: D015195:Drug Design; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends
chemical_list: D043562:Receptors, G-Protein-Coupled