Subclinical Becker's muscular dystrophy presenting with severe heart failure.
We describe a rare case of Becker's muscular dystrophy (BMD) in a 28-year-old man complicated by rapidly progressing heart failure without apparent clinical signs of neuromuscular disease. He showed rhabdomyolysis, which repeatedly occurred causing acute renal failure as heart failure worsened. His serum creatine kinase (CK) level was generally below 300 IU/l. However, it exceeded more than 10,000 IU/l at the time of myoglobinuria. This suggests that the worsening of heart failure could induce rhabdomyolysis in a BMD patient. Gene analysis for BMD should be considered when the elevation of serum CK is noted in heart failure.
Yokota
Ryoji
R
Department of Cardiology, Nara Hospital, Kinki University School of Medicine, Ikoma.
Shirotani
Manabu
M
Kouchi
Ichiro
I
Hirai
Taku
T
Uemori
Noritsugu
N
Ohta
Yoshio
Y
Mitsui
Yoshiyuki
Y
Hattori
Ryuichi
R
D000328:Adult; D015153:Blotting, Western; D002303:Cardiac Output, Low / Q000097:blood / Q000150:complications*; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
D003402:Creatine Kinase