CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes).
Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.
Rakheja
Dinesh
D
Department of Pathology, Children's Medical Center of Dallas and the University of Texas Southwestern Medical Center, Dallas, TX, USA. dinesh.rakheja@utsouthwestern.edu
Narayan
Srinivas B
SB
Pastor
Johanne V
JV
Bennett
Michael J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002417:Cattle; D002784:Cholesterol / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D021962:Membrane Microdomains / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics / Q000378:metabolism; D019308:Palmitic Acid / Q000302:isolation & purification; D011233:Precipitin Tests
D008565:Membrane Proteins; D019308:Palmitic Acid; D002784:Cholesterol