title: Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole.
abstract: Selenium-75 (t1/2 = 120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35 microCi/microAh; maximum current, 6 microA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50 degrees C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.
authors.affiliation: Cyclotron Department, Nuclear Research Center for Agriculture & Medicine, P.O. Box 31585-4395, Karaj, Iran. amirreza.jalilian@yale.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Jalilian
authors.forename: P
authors.initials: P
authors.lastname: Rowshanfarzad
authors.forename: H
authors.initials: H
authors.lastname: Afarideh
authors.forename: A
authors.initials: A
authors.lastname: Shafiee
authors.forename: M
authors.initials: M
authors.lastname: Sabet
authors.forename: M
authors.initials: M
authors.lastname: Kyoumarsi
authors.forename: Gh R
authors.initials: GR
authors.lastname: Raisali
mesh_terms: D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D016566:Organoselenium Compounds / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D011522:Protons; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012644:Selenium Radioisotopes / Q000737:chemistry*; D013696:Temperature
chemical_list: D001152:Arsenicals; D001393:Azoles; D016566:Organoselenium Compounds; D010087:Oxides; D011522:Protons; D019275:Radiopharmaceuticals; D012644:Selenium Radioisotopes; D000077237:Arsenic Trioxide