title: Cortical activation changes associated with motor recovery in patients with precentral knob infarct.
abstract: We investigated the cortical activation changes associated with motor recovery in six hemiparetic patients with precentral knob infarct. fMRI at 1.5 T with finger movements at a fixed rate was performed twice in each patient, 1 and 6 months after stroke onset. From the images obtained, the LI (laterality index) for the primary sensorimotor cortex (SM1) was calculated to measure the degree of the cortical activity concentration in the contralateral hemisphere. Our results showed that a greater improvement in motor function scores was significantly correlated with a greater increment in LI induced by affected finger movements (p < 0.05). Motor recovery after precentral knob infarct was found to be positively related with the concentration of SM1 activity in the ipsilesional hemisphere. This finding may imply motor recovery through cortical reorganization after precentral knob infarct in the human brain.
authors.affiliation: Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University 317-1, Daemyungdong, Namku, Taegu, 705-717, Republic of Korea. strokerehab@hanmail.net
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Jang
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Yong-Hyun
authors.initials: YH
authors.lastname: Kwon
authors.forename: Woo Mok
authors.initials: WM
authors.lastname: Byun
authors.forename: Se Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Park
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Chang
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000502:physiology*; D002544:Cerebral Infarction / Q000150:complications / Q000503:physiopathology*; D005385:Fingers / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010291:Paresis / Q000209:etiology / Q000503:physiopathology
chemical_list: D010100:Oxygen