title: Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins.
abstract: Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin, 1) and 8-acetoxy derivatives (5) (1 micromol/cm(2)) provoked 50% oedema reduction, similarly to 0.25 micromol/cm(2) of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.
authors.affiliation: Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Università degli Studi, Via del Liceo, 06123 Perugia, Italy. curmax@unipg.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Curini
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Federica
authors.initials: F
authors.lastname: Maltese
authors.forename: Maria C
authors.initials: MC
authors.lastname: Marcotullio
authors.forename: Aurelia
authors.initials: A
authors.lastname: Tubaro
authors.forename: Gianmario
authors.initials: G
authors.lastname: Altinier
authors.forename: Sylvia Prieto
authors.initials: SP
authors.lastname: Gonzales
authors.forename: Juan C
authors.initials: JC
authors.lastname: Rodriguez
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice
chemical_list: D000893:Anti-Inflammatory Agents; D003374:Coumarins