HIV infection: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment.
Highly active antiretroviral therapy (HAART) in HIV patients generally increases the CD4 cell count, but the level of CD4 cell restoration remains very heterogeneous. IL-7 is the main cytokine controlling the size of the T-cell pool. We assessed the hypothesis that pre-HAART IL-7 plasma levels may affect CD4 cell restoration after treatment. A positive correlation was found in a cohort of 18 patients between pre-HAART IL-7 plasma levels and CD4 cell increases after 20 +/- 7.8 months of HAART.
Beq
Stéphanie
S
Unité d'ImmunoGénétique Cellulaire, Institut Pasteur, Paris, France.
Rannou
Marie-Thérèse
MT
Fontanet
Arnaud
A
Delfraissy
Jean-François
JF
Thèze
Jacques
J
Colle
Jean-Hervé
JH
D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D011379:Prognosis
D015415:Biomarkers; D015851:Interleukin-7