title: Mitochondrial decay, a major cause of aging, can be delayed.
abstract: Mitochondrial decay due to oxidant byproducts is a principal underlying contributor to aging, including the degenerative diseases of aging such as brain degeneration [15,23,32]. The energy for basic metabolic processes comes from mitochondria, and their decay with age impairs cellular metabolism and leads to cellular decline. Our progress over the last decade in delaying the mitochondrial decay of aging is briefly reviewed.
authors.affiliation: University of California, Berkeley, CA, USA. bames@chori.org
authors.forename: Bruce N
authors.initials: BN
authors.lastname: Ames
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001710:Biotin / Q000172:deficiency / Q000627:therapeutic use; D003300:Copper / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D008903:Minerals / Q000627:therapeutic use; D028361:Mitochondrial Diseases / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control*; D010205:Pantothenic Acid / Q000172:deficiency / Q000627:therapeutic use; D051381:Rats; D014803:Vitamin B Complex / Q000627:therapeutic use*; D015032:Zinc / Q000172:deficiency / Q000627:therapeutic use
chemical_list: D008903:Minerals; D014803:Vitamin B Complex; D010205:Pantothenic Acid; D001710:Biotin; D003300:Copper; D015032:Zinc