title: Autoimmune hepatitis accompanied by systemic lupus erythematosus.
abstract: We report a series of five patients with autoimmune hepatitis (AIH) accompanied by systemic lupus erythematosus (SLE) (AIH-SLE overlap). Serologic tests showed that all patients were positive for antinuclear antibody and double-stranded DNA antibody. Histological examination of the liver showed that three of the patients had chronic hepatitis with severe activity. One of the other two had acute and severe hepatitis with submassive necrosis in both portal and lobular areas. The last patient already had liver cirrhosis. All patients had a mild form of SLE and showed a rapid response to corticosteroid. There was no serious involvement of organs other than the liver in any of the patients, and the prognoses were comparatively good in all patients.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University, School of Medicine, Fukushima.
authors.forename: Jun
authors.initials: J
authors.lastname: Tojo
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Abe
authors.forename: Junko
authors.initials: J
authors.lastname: Yokokawa
authors.forename: Junko
authors.initials: J
authors.lastname: Takiguchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Rai
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Shishido
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sato
authors.forename: Reiji
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D009336:Necrosis; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D011239:Prednisolone