No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.
Several groups have reported that abnormal phosphorylation of tau by Fyn, a protein-tyrosine kinase, may play a role in the neuropathogenesis of Alzheimer's disease (AD). In the present study, three common Japanese polymorphisms of the Fyn gene (-93A/G in the 5'-flanking region, IVS10+37T/C in intron 10 and Ex12+894T/G in the 3'-untranslated region) were studied in 127 healthy controls and 182 sporadic AD cases using a polymerase chain reaction restriction fragment length polymorphism method. A comparison of the allelic and genotypic frequencies of these polymorphisms between controls and sporadic AD cases failed to show any significant difference. These results suggest that the Fyn polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) investigated here have no genetic association with sporadic AD.
Watanabe
Tomoko
T
Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 343-0032, Japan. tomoko-w@med.juntendo.ac.jp
Ohnuma
Tohru
T
Shibata
Nobuto
N
Ohtsuka
Mieko
M
Ueki
Akira
A
Nagao
Masatsugu
M
Arai
Heii
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051076:Proto-Oncogene Proteins c-fyn
D011518:Proto-Oncogene Proteins; C494957:FYN protein, human; D051076:Proto-Oncogene Proteins c-fyn