title: [Contribution of high pressure to pharmaceutical and medical science].
abstract: Since the beginning of the 20th century, effects of high pressure on biological systems have been studied, but the first applications in this domain have been developed in the 90's and concerned the preservation of food-stuff. Hence, much research work has been undertaken in order to develop high pressure effects in Biosciences. In the last decade, new methods or processes using high pressure (obtaining therapeutic molecules; decontamination or sterilization of biological stuff, sensitive drugs and drug carriers; development of vaccines; using high pressure as a tool in order to simulate and explore the mechanisms of proteins aggregation) underlining the potentialities of this technology in Medical and Pharmaceutical Sciences.
authors.affiliation: LPCHP, Laboratoire de physico-chimie des hautes pressions (Interface hautes pressions ENSCPB-ICMCB), Ecole nationale supérieure de chimie et de physique de Bordeaux (ENSCPB), 16, avenue Pey Berland, F33608 Pessac Cedex.
authors.forename: Y
authors.initials: Y
authors.lastname: Rigaldie
authors.forename: G
authors.initials: G
authors.lastname: Demazeau
mesh_terms: D035843:Biomedical Research; D001709:Biotechnology; D002626:Chemistry, Pharmaceutical / Q000639:trends*; D004364:Pharmaceutical Preparations; D011312:Pressure; D011328:Prions / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D014612:Vaccines
chemical_list: D004364:Pharmaceutical Preparations; D011328:Prions; D011506:Proteins; D014612:Vaccines