Pericarditis associated with Epstein-Barr virus reactivation in a patient following allogeneic peripheral blood stem cell transplantation from an HLA genotypic 1-locus mismatched sibling donor.
A 31-year-old woman with acute myeloblastic leukemia (AML) underwent allogeneic peripheral blood stem cell transplant (PBSCT). On day +274 following transplantation, the patient had severe chest pain, high-grade fever, and general fatigue. Electrocardiographic examination revealed ST segment elevation, and echocardiographic examination revealed an obvious pericardial. The diagnosis of pericarditis was made. We could not exclude the possibility of a combination of chronic GVHD involving the liver, because biochemistry examination revealed altered liver dysfunction, but liver biopsy was not performed. The patient underwent empirical treatment for bacterial or viral infection, and was given prednisolone for chronic GVHD. Retrospective serologic examination revealed that EBV reactivation had occurred at this time. This is the first reported case of pericarditis associated with EBV reactivation after allogeneic-stem cell transplantation (allo-SCT).
Aoyama
Yasutaka
Y
Department of Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Nakao
Yoshitaka
Y
Ohta
Kensuke
K
Sakai
Tomoko
T
Nakamae
Hirohisa
H
Yamamura
Ryousuke
R
Yamane
Takahisa
T
Hino
Masayuki
M
D000328:Adult; D004562:Electrocardiography; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008099:Liver / Q000473:pathology; D010493:Pericarditis / Q000175:diagnosis* / Q000628:therapy / Q000821:virology*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D011239:Prednisolone / Q000627:therapeutic use; D035781:Siblings; D013997:Time Factors; D014184:Transplantation, Homologous / Q000379:methods*
D011239:Prednisolone