title: Infliximab in the treatment of ulcerative colitis with toxic megacolon.
abstract: Toxic megacolon is a gastrointestinal emergency requiring prompt management to avoid fatal outcome. Although a majority of patients respond to conservative treatment, those not responding have been treated with intravenous cyclosporine or emergency surgery. Infliximab has been tried in patients with severe steroid-refractory ulcerative colitis. We report the successful use of this drug in the management of toxic megacolon in a 48-year-old woman not responding to the routine measures and who refused surgery.
authors.affiliation: Department of Gastroenterology Surgery, Asian Institute of Gastroenterology, Hyderabad 500 082.
authors.forename: Parupudi V J
authors.initials: PV
authors.lastname: Sriram
authors.forename: K S Pavan
authors.initials: KS
authors.lastname: Reddy
authors.forename: Guduru V
authors.initials: GV
authors.lastname: Rao
authors.forename: Darisetty
authors.initials: D
authors.lastname: Santosh
authors.forename: Duvvuru Nageshwar
authors.initials: DN
authors.lastname: Reddy
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D000069285:Infliximab; D008297:Male; D008532:Megacolon, Toxic / Q000150:complications* / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D000069285:Infliximab