[In vivo anti-tumor effect of polysaccharide from Sargassum confusum and the mechanisms].
OBJECTIVE
To study the anti-tumor effects of polysaccharide from Sargassum confusum in mice and explore the possible mechanisms. Methods Forty-five mice bearing transplanted tumor S180 were used to study the effects of polysaccharide on the tumor weight, thymus gland and spleen. The changes in serum contents of SOD, glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) content were assayed.


RESULTS
The polysaccharide from Sargassum confusum significantly inhibited the growth of S180 tumor in mice and enhanced the functions of the immune organs. SOD content and GSH-PX activity were significantly increased from 350.76+/-31.34 NU/ml, 299.36+/-43.63 U to 487.76+/-16.67 NU/ml,370.90+/-16.49 U(P<0.01), MDA content decreased from 9.46+/-1.77 nmol/ml to 7.26+/-1.18 nmol/ml in the serum after polysaccharide treatment.


CONCLUSIONS
The anti-tumor effect of the polysaccharide from Sargassum confusum can be attributed to improve functions of the immune organs and enhance anti-oxidative capacity in tumor-bearing mice.
Liu
Qiu-ying
QY
Analytical Center, Guangdong Medical College, Zhanjiang 524023, China. liuqy2001@sohu.com
Meng
Qing-yong
QY
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology* / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy; D044647:Sargassum / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D000975:Antioxidants; D011134:Polysaccharides