title: Compound melanocytic nevi with granular cell changes.
abstract: Two cases of compound melanocytic nevi with granular cell changes were studied. Histological examination revealed compound melanocytic nevi with a portion of the dermal component exhibiting a sheet like proliferation of nevoid cells with granular cytoplasm. Immunohistochemically, both populations of cells stained positive for S-100 and Melan-A. However, HMB-45 was positive only for the nevus cells with granular cytoplasm. We believe this represents granular cytoplasmic changes of nevus cells and does not denote malignant transformation.
authors.affiliation: Department of Dermatology Indiana University, School of Medicine, Indianapolis, Indiana, USA.
authors.forename: Hatem M
authors.initials: HM
authors.lastname: El-Gamal
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
authors.forename: Kirk D
authors.initials: KD
authors.lastname: Saddler
authors.forename: Teddy
authors.initials: T
authors.lastname: Pan
authors.forename: Martin C
authors.initials: MC
authors.lastname: Mihm
mesh_terms: D000293:Adolescent; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D008297:Male; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000032:analysis; D009508:Nevus, Pigmented / Q000737:chemistry / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins