title: Towing of sensory axons by their migrating target cells in vivo.
abstract: Many pathfinding axons must locate target fields that are themselves positioned by active migration. A hypothetical method for ensuring that these migrations are coordinated is towing, whereby the extension of axons is entirely dependent on the migration of their target cells. Here we combine genetics and time-lapse imaging in the zebrafish to show that towing by migrating cells is a bona fide mechanism for guiding pathfinding axons in vivo.
authors.affiliation: Max Planck Institut für Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tuebingen, Germany. darren.gilmour@tuebingen.mpg.de
authors.forename: Darren
authors.initials: D
authors.lastname: Gilmour
authors.forename: Holger
authors.initials: H
authors.lastname: Knaut
authors.forename: Hans-Martin
authors.initials: HM
authors.lastname: Maischein
authors.forename: Christiane
authors.initials: C
authors.lastname: Nüsslein-Volhard
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D001369:Axons / Q000502:physiology*; D002450:Cell Communication / Q000235:genetics*; D002465:Cell Movement / Q000502:physiology*; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000378:metabolism; D003952:Diagnostic Imaging / Q000379:methods; D004625:Embryo, Nonmammalian; D049452:Green Fluorescent Proteins; D020439:Growth Cones; D017403:In Situ Hybridization / Q000379:methods; D008164:Luminescent Proteins; D009475:Neurons, Afferent / Q000166:cytology / Q000502:physiology* / Q000637:transplantation; D019718:Receptors, CXCR4 / Q000235:genetics; D015398:Signal Transduction; D013997:Time Factors; D014180:Transplantation / Q000379:methods; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000235:genetics
chemical_list: C471276:CXCR4b protein, zebrafish; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D008164:Luminescent Proteins; D019718:Receptors, CXCR4; D029961:Zebrafish Proteins; D049452:Green Fluorescent Proteins