title: Fingernail clubbing and chromonychia associated with the use of angiotensin II receptor blockers.
abstract: Fingernail clubbing and discoloration frequently indicate serious pulmonary, cardiovascular, and gastrointestinal pathologies. A 76-year-old Caucasian man developed clubbing of the fingernails and discoloration of both the fingernails and toenails after 27 days of treatment with the angiotensin II receptor blocker (ARB) losartan 50 mg/day. Even though this therapy was switched to valsartan, the nail changes persisted for another 6 months. The patient's therapy then was changed to captopril, and the changes gradually subsided over 17 months. An extensive literature search revealed no reports of this effect in association with ARBs. However, one manufacturer had received spontaneous reports. Despite careful consideration of other possible causes of the patient's symptoms, the temporal association with the start and discontinuation of ARB therapy suggests a possible drug-related adverse event.
authors.affiliation: Creighton University Cardiac Center, Omaha, Nebraska 68131, USA.
authors.forename: Kathleen A
authors.initials: KA
authors.lastname: Packard
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Arouni
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Hilleman
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Gannon
mesh_terms: D000368:Aged; D000804:Angiotensin II; D057911:Angiotensin Receptor Antagonists; D005385:Fingers; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D019808:Losartan / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009260:Nail Diseases / Q000139:chemically induced*; D014034:Toes
chemical_list: D057911:Angiotensin Receptor Antagonists; D000804:Angiotensin II; D019808:Losartan