Synthesis, radioiodination, and biodistribution of some nido- and closo-monocarbon carborane derivatives.
Iodination and radioiodination reactions of several anionic nido- and closo-monocarbon carboranes were conducted. Iodinations occurred more rapidly with nido-carboranes than with closo-carboranes. The most rapid iodination and radioiodination reactions occurred with unsubstituted carboranes. C-amino and C-ammonium derivatives did not iodinate under the conditions studied. Both nido- and closo-carboranes with C-NH-acetyl and C-NH-succinyl substituents iodinated, but the nido-carboranes iodinated under milder reaction conditions. Biodistributions of nido-1-succinylamido-[(131)I]carborane and closo-1-succinylamido-[(125)I]carborane were similar in mice, but blood clearance of the nido- compound was slower.
Wilbur
D Scott
DS
Department of Radiation Oncology, University of Washington, 2121 N. 35th Street, Seattle, WA 98103, USA. dswilbur@u.washington.edu
Hamlin
Donald K
DK
Srivastava
Rajiv R
RR
Chyan
Ming-Kuan
MK
D000818:Animals; D001880:Boranes / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D017554:Carbon Compounds, Inorganic / Q000138:chemical synthesis / Q000493:pharmacokinetics; D007457:Iodine Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics*; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D014018:Tissue Distribution
D001880:Boranes; D017554:Carbon Compounds, Inorganic; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals