The use of zebrafish to understand immunity.
For decades immunologists have relied heavily on the mouse model for their experimental designs. With the realization of the important role innate immunity plays in orchestrating immune responses, invertebrates such as worms and flies have been added to the repertoire. Here, we discuss the advent of the zebrafish as a powerful vertebrate model organism that promises to positively impact immunologic research.
Trede
Nikolaus S
NS
Division of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 USA. trede@enders.tch.harvard.edu
Langenau
David M
DM
Traver
David
D
Look
A Thomas
AT
Zon
Leonard I
LI
D000818:Animals; D019070:Cell Lineage / Q000276:immunology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015870:Gene Expression; D007113:Immunity, Innate; D051379:Mice; D015027:Zebrafish / Q000276:immunology*