title: Heme oxygenase induction protects liver against oxidative stress in x-irradiated aged rats.
abstract: We studied the effect of total body X-ray irradiation on the heme oxygenase-1 (HO-1) induction in the livers of young and aged rats. For this purpose, male rats were irradiated with a dose of 17 Gy. The animals were killed 5 h after irradiation. HO-1 protein expression was found to be increased two fold in aged rat liver, but lipid peroxide levels had decreased significantly where no change was observed either in inducible nitric oxide synthase protein expression or in glutathione levels. Contradictory results with respect to HO-1 and lipid peroxidation levels were obtained in the livers of young animals. These results suggest that the additional oxidative stress produced in irradiated rats may be compensated by HO-1 induction as decreased lipid peroxide levels were shown in the livers of aged animals.
authors.affiliation: Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey. oztezcan@istanbul.edu.tr
authors.forename: Serdar
authors.initials: S
authors.lastname: Oztezcan
authors.forename: Banu
authors.initials: B
authors.lastname: Kirgiz
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Unlüçerçi
authors.forename: Semra
authors.initials: S
authors.lastname: Doğru-Abbasoğlu
authors.forename: Hatice
authors.initials: H
authors.lastname: Bilge
authors.forename: Müjdat
authors.initials: M
authors.lastname: Uysal
authors.forename: Gülçin
authors.initials: G
authors.lastname: Aykaç-Toker
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004790:Enzyme Induction; D005978:Glutathione / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing); D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology / Q000528:radiation effects; D008297:Male; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D018384:Oxidative Stress; D010105:Oxygenases / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014965:X-Rays
chemical_list: D006360:Heat-Shock Proteins; D010105:Oxygenases; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D006419:Heme Oxygenase (Decyclizing); C491523:Hmox1 protein, rat; D005978:Glutathione