Totally chemo- and regioselective cobalt(I)-mediated formal intermolecular cyclotrimerization of alkynes.
[reaction: see text] The first examples of totally chemo- and regioselective formal intermolecular cobalt(I)-catalyzed [2 + 2 + 2] cyclizations of three different alkynes are reported. The use of disposable silylated tethers in the sequence cyclization followed by the displacement of the silicon group led to polysubstituted arenes as a unique cycloadduct in high yields.
Chouraqui
Gaëlle
G
Université Pierre et Marie Curie (Paris 6), Laboratoire de Chimie Organique associé au CNRS, Tour 44-54, 2ème étage, case 229, 4 place Jussieu, 75252, Paris Cedex 05, France.
Petit
Marc
M
Aubert
Corinne
C
Malacria
Max
M