title: [Analysis on association between the polymorphisms in apolipoprotein E, interleukin-1 alpha genes and Alzheimer's disease in Chengdu area].
abstract: OBJECTIVE
  To investigate the correlation between the polymorphisms of apolipoprotein E(APOE), the interleukin-1 alpha (IL-1 alpha ) genes and the susceptibility to Alzheimer's disease(AD).
  
  
  METHODS
  Association study was performed in 114 AD patients and 113 healthy elderly individuals from Chengdu, China. Polymorphisms of APOE and IL-1 alpha genes were analyzed with polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The frequency of APOE-epsilon 4-carrying genotype in moderate to severe AD patients (28.6%) was higher than that of mild patients (18.5%) and the controls (14.2%), and the difference between moderate to severe AD group and the control group was significant (OR=2.4, 95%CI: 1.1-5.5). The frequency of epsilon 4 was also of significant difference between the group of moderate to severe dementia and the control group (OR=2.6, 95%CI: 1.3-5.3). However, no significant difference in distribution of IL-1 alpha polymorphism between AD patients and controls was observed.
  
  
  CONCLUSIONS
  The APOE epsilon 4 allele was associated with moderate to severe AD while no association between the IL-1 alpha gene polymorphism and AD was found.
authors.affiliation: Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 PR China. tangmuni@hotmail.com
authors.forename: Mu-ni
authors.initials: MN
authors.lastname: Tang
authors.forename: Zhen-xin
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Han
authors.forename: Xie-he
authors.initials: XH
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D007375:Interleukin-1