title: Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.
abstract: Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity.
authors.affiliation: College of Pharmacy and Natural Products Research Institute, Seoul National University, Seoul 110-460, South Korea.
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Lee
authors.forename: Yoo Keum
authors.initials: YK
authors.lastname: Choi
authors.forename: Gap Seok
authors.initials: GS
authors.lastname: Kim
authors.forename: Byung Hee
authors.initials: BH
authors.lastname: Han
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D047309:Flavones / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*
chemical_list: D047309:Flavones; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D006861:Hydrogen Peroxide