Experimental autoimmune hearing loss.
Understanding of autoimmune sensorineural hearing loss (ASNHL) has been hindered by the inaccessibility of the inner ear to biopsy and the lack of workable animal models. A report in this issue of the JCI describes a mouse model of CD4(+) T cell-mediated ASNHL induced by immunization with peptides from the inner ear-specific proteins cochlin and beta-tectorin.
Billings
Peter
P
Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, and Research Service of the Department of Veterans Affairs, San Diego, California 92161, USA. pbillings@ucsd.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004195:Disease Models, Animal; D016326:Extracellular Matrix Proteins / Q000276:immunology*; D058851:GPI-Linked Proteins; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D007114:Immunization; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D011506:Proteins / Q000276:immunology*
C491729:Coch protein, mouse; D016326:Extracellular Matrix Proteins; D058851:GPI-Linked Proteins; D008565:Membrane Proteins; D011506:Proteins; C093123:TECTB protein, human