Mitochondrial toxicity associated with HAART following liver transplantation in an HIV-infected recipient.
Antiretroviral therapy is not uncommonly associated with drug toxicities, and hepatotoxicity occurs in approximately 20% of individuals prescribed antiretroviral therapy. Mitochondrial toxicity causing lactic acidosis is a rare but fatal complication that has been described in some HIV-infected patients treated with nucleoside analogue reverse transcriptase inhibitors. In this report, we describe the course of an HIV-infected patient receiving antiretroviral therapy who developed lactic acidosis after liver transplantation for HCV-induced liver disease.
Antoniades
Charalambos
C
Institute of Liver Studies, King's College Hospital, Denmark Hill, London SE 5 9RS, UK.
Macdonald
Candice
C
Knisely
Alexander
A
Taylor
Christopher
C
Norris
Suzanne
S
D000140:Acidosis, Lactic / Q000209:etiology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D001381:Azepines; D001707:Biopsy, Needle; D015897:Comorbidity; D024841:Fluoroquinolones; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006526:Hepatitis C / Q000453:epidemiology* / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D011184:Postoperative Period; D015363:Quinolones
D001381:Azepines; C098269:FA-103; D024841:Fluoroquinolones; D015363:Quinolones