title: Expression of type IV collagen by Lewis pulmonary carcinoma cells.
abstract: Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type IV collagen) in PLMG-M1 culture was 1.6 and 2.2 times lower than in PLMG-M2 and PLMG-T cultures, respectively. It was found that cell culture medium modulated expression of type IV collagen and this effect was mediated via cell receptors.
authors.affiliation: M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
authors.forename: G P
authors.initials: GP
authors.lastname: Gaenko
authors.forename: S V
authors.initials: SV
authors.lastname: Khaidukov
authors.forename: Yu G
authors.initials: YG
authors.lastname: Molotkovskii
mesh_terms: D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000276:immunology / Q000378:metabolism*; D045744:Cell Line, Tumor; D024141:Collagen Type IV / Q000032:analysis / Q000378:metabolism*; D003470:Culture Media / Q000494:pharmacology; D005109:Extracellular Matrix / Q000187:drug effects; D051379:Mice
chemical_list: D024141:Collagen Type IV; D003470:Culture Media