title: Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration.
abstract: A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400 microg/paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.
authors.affiliation: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. nylanenunes@hotmail.com
authors.forename: Nylane M N
authors.initials: NM
authors.lastname: Alencar
authors.forename: Ana M S
authors.initials: AM
authors.lastname: Assreuy
authors.forename: David N
authors.initials: DN
authors.lastname: Criddle
authors.forename: Emmanuel P
authors.initials: EP
authors.lastname: Souza
authors.forename: Pedro M G
authors.initials: PM
authors.lastname: Soares
authors.forename: Alexandre
authors.initials: A
authors.lastname: Havt
authors.forename: Karoline S
authors.initials: KS
authors.lastname: Aragão
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Bezerra
authors.forename: Ronaldo A
authors.initials: RA
authors.lastname: Ribeiro
authors.forename: Benildo S
authors.initials: BS
authors.lastname: Cavada
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D004487:Edema / Q000139:chemically induced* / Q000473:pathology; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006614:Hindlimb / Q000473:pathology; D007279:Injections, Subcutaneous; D007962:Leukocytes / Q000187:drug effects / Q000473:pathology; D037121:Plant Lectins / Q000302:isolation & purification* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000033:anatomy & histology / Q000737:chemistry
chemical_list: D037121:Plant Lectins