Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum.
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively.
Hegde
Vinod R
VR
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hedge@spcorp.com
Pu
Haiyan
H
Patel
Mahesh
M
Black
Todd
T
Soriano
Aileen
A
Zhao
Wenjun
W
Gullo
Vincent P
VP
Chan
Tze-Ming
TM
D001419:Bacteria / Q000201:enzymology*; D019915:DNA Primase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045468:Fallopia japonica / Q000737:chemistry*; D013057:Spectrum Analysis
D004791:Enzyme Inhibitors; D019915:DNA Primase