[Relationship between heat shock protein 70-hom gene polymorphism and ankylosing spondylitis].
OBJECTIVE
To investigate the association between heat shock protein 70-hom (HSP70-hom) gene polymorphism and ankylosing spondylitis(AS) in Chinese Han patients.


METHODS
Genomic DNA from 98 Chinese AS patients and 70 ethnically matched controls were typed for HSP70-hom polymorphism by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
The HSP70-hom genotypes in the AS patients consisted of homozygote AA (60.2%) and BB(4.1%), and heterozygote(35.7%), while the HSP70-hom genotypes in the controls were composed of AA(58.6%), BB(2.9%) and heterozygote(38.6%). No significant difference was found in the distribution of HSP70-hom genotype between these two groups(chi(2) test=0.280, P>0.05). The frequencies of HSP70-hom alleles in AS patients were 77.9%(AA) and 22.1%(BB), while they were 78.1% and 21.9% in the controls. The frequency of HSP70-hom allele in AS patients was not significantly increased, compared with that in controls (chi(2) test=0.002, P>0.05).


CONCLUSIONS
There may be no association between the HSP70-hom gene polymorphism and ankylosing spondylitis in Chinese Han population.
Lin
Jing-an
JA
Center of Research, First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005 PR China. Linjingan@21cn.com
Ye
De-fu
DF
Zhu
Yue-yong
YY
Chen
Jun-min
JM
Zheng
Wei-qing
WQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013167:Spondylitis, Ankylosing / Q000235:genetics*
D018840:HSP70 Heat-Shock Proteins