Palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings or oxidized five-membered trifluoroacetates.
We describe palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings by water-originated hydride addition. Mechanistic features of this anomalous carbocyclization and isolation of a chiral five-membered C-Pd intermediate as an oxidized form of trifluoroacetate are also reported.
Mikami
Koichi
K
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan. kmikami@o.cc.titech.ac.jp
Hatano
Manabu
M