Reversible bilateral internuclear ophthalmoplegia associated with FK506.
A 50 year old man developed tonic-clonic seizures while receiving cyclosporin A after orthotopic cardiac transplant. The seizures resolved after cessation of cyclosporin A. Thirteen months later, he developed diplopia from bilateral internuclear ophthalmoplegia while receiving intravenous FK506. A temporal association was found between his symptoms and the serum FK506 concentrations. Withdrawal of the intravenous FK506 led to prompt resolution of the bilateral internuclear ophthalmoplegia.
Lai
M M
MM
Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
Kerrison
J B
JB
Miller
N R
NR
D006084:Graft Rejection / Q000188:drug therapy; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000139:chemically induced* / Q000175:diagnosis; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016559:Tacrolimus