title: Non-Alzheimer's disease dementias: anatomic, clinical, and molecular correlates.
abstract: OBJECTIVE
  To review the clinical and molecular features of non-Alzheimer's disease (non-AD) dementias, focusing on disorders associated with tau pathology (that is, frontotemporal lobar degeneration [FTLD], corticobasal ganglionic degeneration [CBD], and progressive supranuclear palsy [PSP]) or on disorders with synuclein pathology (that is, dementia with Lewy bodies [DLB] and multisystem atrophy [MSA]). We also discuss the pharmacologic treatment of these disorders.
  
  
  METHODS
  We report a selective review of the literature on FTLD, CBD, PSP, DLB, and MSA.
  
  
  RESULTS
  The non-AD dementias can present with a wide variety of cognitive and behavioural symptoms. Through common clinical features and shared molecular etiologies, neurodegenerative disorders previously thought to be distinct are now classified into tauopathies and synucleinopathies.
  
  
  CONCLUSIONS
  The unique cognitive and behavioural manifestations of the non-AD dementias can be mistaken for psychiatric disorders. Improved detection of tauopathies and synucleinopathies and their differentiation from AD is possible.
authors.affiliation: Department of Neurology, University of California at San Francisco, USA. craig.hou@memory.ucsf.edu
authors.forename: Craig E
authors.initials: CE
authors.lastname: Hou
authors.forename: Danielle
authors.initials: D
authors.lastname: Carlin
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051843:Synucleins; D024801:Tauopathies / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D016875:tau Proteins / Q000235:genetics*
chemical_list: D009419:Nerve Tissue Proteins; D051843:Synucleins; D016875:tau Proteins