title: PheP, a putative amino acid permease of Staphylococcus aureus, contributes to survival in vivo and during starvation.
abstract: PheP, a putative amino acid permease in Staphylococcus aureus, contributes to starvation survival under glucose-limiting conditions and virulence. A pheP mutation led to poor growth after microaerobic or anaerobic incubation on pig serum agar, which was recovered by phenylalanine addition. Genetic complementation of pheP restored growth and starvation survival.
authors.affiliation: Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom.
authors.forename: Malcolm J
authors.initials: MJ
authors.lastname: Horsburgh
authors.forename: Michael D
authors.initials: MD
authors.lastname: Wiltshire
authors.forename: Howard
authors.initials: H
authors.lastname: Crossley
authors.forename: Eileen
authors.initials: E
authors.lastname: Ingham
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Foster
mesh_terms: D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D013203:Staphylococcal Infections / Q000209:etiology; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity; D013552:Swine; D014774:Virulence
chemical_list: D026905:Amino Acid Transport Systems; D004269:DNA, Bacterial; D010649:Phenylalanine