[Effect of ketamine on cerebral circulation of intact and ischemic animals].
The influence of ketamine on the local cerebral circulation was studied in intact rats and under the conditions of global brain ischemia. The drug increased the local blood flow in intact rats. Despite pronounced hypotension accompanying the global brain ischemia, ketamine helped maintenance of the cerebral circulation.
Melkumian
V S
VS
Pharmacology Department, State Pharmaceutical Academy, ul. Kalinina 11, Pyatigorsk, 357500 Russia.
Khaĭlov
N A
NA
Gaevyĭ
M D
MD
D000818:Animals; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D007649:Ketamine / Q000627:therapeutic use*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine