title: Immunomodulatory effects of aqueous extract of Tridax procumbens in experimental animals.
abstract: The immunomodulatory properties of ethanol insoluble fraction of aqueous extract of Tridax procumbens Linn. (TPEIF) have been investigated. After intraperitoneal administration of TPEIF in doses of 0.25 and 0.5 g/kg body weight (BW) a significant increase in phagocytic index, leukocyte count and spleenic antibody secreting cells was noticed. Stimulation of humoral immune response was further observed with elevation in heamagglutination antibody titer. Heightened delayed type hypersensitivity reaction suggested convincing evidence for activation of cellular immune system. Protective action of herbal medicine in case of anaphylactic shock was also studied. In addition, elicitation of specific antibody titer against tetanus toxoid (TT) challenge was measured in order to explore the possible use as adjuvant along with clinical vaccination program to reduce number of non-responders. The results suggest that TPEIF influences both humoral as well as cell mediated immune system vis-a-vis assists in genesis of improved antibody response against specific clinical antigen.
authors.affiliation: Department of Zoology, Dr. Harisingh Gour University, Sagar 470003, MP, India.
authors.forename: Umesh
authors.initials: U
authors.lastname: Tiwari
authors.forename: Bhawna
authors.initials: B
authors.lastname: Rastogi
authors.forename: Paramjit
authors.initials: P
authors.lastname: Singh
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Saraf
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D019659:Asteraceae; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013154:Spleen / Q000187:drug effects* / Q000276:immunology; D013745:Tetanus Toxoid / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D013745:Tetanus Toxoid