HLA-B27: a registry of constitutive peptide ligands.
The very strong association of human leukocyte antigen (HLA)-B27 with spondyloarthritis might be related to its peptide-presenting properties. The natural polymorphism of this molecule influences both peptide specificity and disease susceptibility. In this study, we present a comprehensive compilation of known natural ligands of HLA-B27 arising from endogenous proteins of human cells, together with a statistical assessment of residue usage among constitutive peptide repertoires of multiple HLA-B27 subtypes. This analysis provides evidence that every peptide position, including "non-anchor" ones, may be subjected to selection on the basis of its contribution to HLA-B27 binding and also allows a quantization of residue preferences at known anchor positions. The present registry is intended as a basis on which to build up reliable criteria to assess the effect of HLA-B27 polymorphism on peptide presentation, for T-cell epitope predictions, and for molecular mimicry studies.
Lopez de Castro
J A
JA
Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid), Universidad Autónoma, 28049 Madrid, Spain. aldecastro@cbm.uam.es
Alvarez
I
I
Marcilla
M
M
Paradela
A
A
Ramos
M
M
Sesma
L
L
Vázquez
M
M
D000595:Amino Acid Sequence; D017951:Antigen Presentation; D002460:Cell Line; D002472:Cell Transformation, Viral; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D015796:HLA-B27 Antigen / Q000235:genetics* / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D010455:Peptides / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D011485:Protein Binding; D025241:Spondylarthritis / Q000276:immunology
D015796:HLA-B27 Antigen; D008024:Ligands; D010455:Peptides