title: [A case of primary small cell carcinoma in the common bile duct].
abstract: Extrapulmonary primary small cell carcinoma comprises approximately 4% of all small cell carcinoma. In the common bile duct, small cell carcinomas are extremely rare. We experienced a 60-year-old woman with small cell carcinoma arising in the common bile duct. Abdominal CT scan revealed an intraluminal mass in the proximal common bile duct and multiple lymphadenopathies. Microscopic examination of the tumor revealed proliferation of small monotonous anaplastic cells, which were characterized with hyperchromatic nuclei, high nuclear to cytoplasmic ratio, and frequent mitosis. By immunohistochemical stain, the tumor cells were strongly positive for chromogranin, synaptophysin, and CD56. We report this case with a review of literatures.
authors.affiliation: Department of Internal Medicine, Keimyung University College of Medicine, Dongsan Medical Center, 194 Dongsan-dong, Jung-gu, Daegu 700-712, Korea.
authors.forename: Hea Won
authors.initials: HW
authors.lastname: Park
authors.forename: Sang Hyuck
authors.initials: SH
authors.lastname: Seo
authors.forename: Byoung Kuk
authors.initials: BK
authors.lastname: Jang
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Hwang
authors.forename: Kyung Sik
authors.initials: KS
authors.lastname: Park
authors.forename: Kwang Bum
authors.initials: KB
authors.lastname: Cho
authors.forename: Jae Seok
authors.initials: JS
authors.lastname: Hwang
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Ahn
authors.forename: Koo Jeong
authors.initials: KJ
authors.lastname: Kang
authors.forename: Yu Na
authors.initials: YN
authors.lastname: Kang
authors.forename: Gab Chul
authors.initials: GC
authors.lastname: Kim
mesh_terms: D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged