title: Multiple meningiomas arising during long-term therapy with the progesterone agonist megestrol acetate. Case report.
abstract: In this report the authors describe a woman with low-grade endometrial stromal sarcoma who was treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. After receiving megestrol acetate continuously for 19 years for chronic hormone suppression, she began to experience progressive dementia. Magnetic resonance imaging revealed 11 separate intracranial meningiomas of various sizes. The largest lesions were treated with staged angiographically guided embolization and excision. Despite discontinuation of megestrol acetate, the remaining smaller lesions grew slightly in size, requiring further treatment with a combination of excision and gamma knife stereotactic surgery. All of the excised tumors showed positive staining for progesterone receptors on immunohistochemical examination. Prolonged therapy with megestrol acetate could promote the growth of benign intracranial meningiomas in some patients.
authors.affiliation: Department of Neurosurgery, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA. tjgruber@buffalo.edu
authors.forename: Thomas
authors.initials: T
authors.lastname: Gruber
authors.forename: Amos O
authors.initials: AO
authors.lastname: Dare
authors.forename: Lucy L
authors.initials: LL
authors.lastname: Balos
authors.forename: Shashi
authors.initials: S
authors.lastname: Lele
authors.forename: Robert A
authors.initials: RA
authors.lastname: Fenstermaker
mesh_terms: D003704:Dementia / Q000209:etiology; D004621:Embolization, Therapeutic; D016889:Endometrial Neoplasms / Q000628:therapy*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D019290:Megestrol Acetate / Q000009:adverse effects*; D008577:Meningeal Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008579:Meningioma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D019635:Neurosurgical Procedures; D011374:Progesterone / Q000819:agonists; D011372:Progestins / Q000009:adverse effects*; D016634:Radiosurgery; D018203:Sarcoma, Endometrial Stromal / Q000628:therapy*; D013997:Time Factors
chemical_list: D011372:Progestins; D011374:Progesterone; D019290:Megestrol Acetate