Salivary production of IgA and IgG to human herpes virus 8 latent and lytic antigens by patients in whom Kaposi's sarcoma has regressed.
IgG and IgA antibodies with specificities to a latent and a lytic antigen of human herpes virus 8 (HHV-8) were detectable in the saliva and serum of eight patients whose Kaposi's sarcoma had regressed, seven of whom were HIV-1 infected. The measurement of antibody-specific activity and secretion rate, and the detection of secretory IgA all indicate anti-HHV-8 antibody activity in saliva. The specific humoral responses possibly influence mucosal replication of HHV-8, and in turn, that of HIV.
Mbopi-Keou
Francois-Xavier
FX
Department of Oral Medicine, Eastman Institute for Oral Health Care Sciences, University College London, London, UK.
Legoff
Jerome
J
Piketty
Christophe
C
Hocini
Hakim
H
Malkin
Jean-Elie
JE
Inoue
Naoki
N
Scully
Crispian M
CM
Porter
Stephen R
SR
Teo
Chong-Gee
CG
Belec
Laurent
L
D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D012514:Sarcoma, Kaposi / Q000378:metabolism*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G