title: Bacterial endocarditis complicating mitral annular calcification: a clinical and echocardiographic study.
abstract: OBJECTIVE
  Although described in a number of necropsy studies, endocarditis on mitral annular calcification (MAC) has rarely been reported during life. The study aim was to assess the frequency and specific features of bacterial endocarditis complicating MAC.
  
  
  METHODS
  Data relating to 62 cases of infective endocarditis of the native mitral valve diagnosed with multiplane transesophageal echocardiography (TEE) over a five-year period were collected prospectively.
  
  
  RESULTS
  Among 62 patients, 15 (24%) had vegetations originating from a calcified mitral annulus (group 1), while 47 had classic leaflet endocarditis (group 2). Group 1 patients differed significantly from group 2 patients with regard to: (i) higher incidence of diabetes mellitus and cancers; (ii) initial clinical presentation, with febrile coma or meningoencephalitis in 53% of cases; (iii) echocardiographic features, with significantly greater vegetations, presence of calcium-dense echoes within the vegetation, high frequency of ring abscess, and high frequency of para-annular ventriculoatrial leakage; and (iv) poorer clinical outcome, with 53% in-hospital mortality.
  
  
  CONCLUSIONS
  MAC appears to be an underestimated predisposing factor for a particularly severe type of bacterial endocarditis. The use of multiplane TEE should improve current knowledge of this disease.
authors.affiliation: Department of Cardiology, University Hospital, Dijon, France. jean-christophe.eicher@chu-dijon.fr
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Eicher
authors.forename: Laurence
authors.initials: L
authors.lastname: De Nadai
authors.forename: Francois-Xavier
authors.initials: FX
authors.lastname: Soto
authors.forename: Sylvie
authors.initials: S
authors.lastname: Falcon-Eicher
authors.forename: Petr
authors.initials: P
authors.lastname: Dobsák
authors.forename: Gilbert
authors.initials: G
authors.lastname: Zanetta
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Petit
authors.forename: Henry
authors.initials: H
authors.lastname: Portier
authors.forename: Pierre
authors.initials: P
authors.lastname: Louis
authors.forename: Jean-Eric
authors.initials: JE
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology*; D006348:Cardiac Surgical Procedures; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology*; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000382:microbiology*; D010343:Patient Admission; D011183:Postoperative Complications / Q000209:etiology / Q000401:mortality; D015995:Prevalence; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology*; D013290:Streptococcal Infections / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000382:microbiology*; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers