title: Immunological effects of environmental exposure to polychlorinated biphenyls and dioxins in Dutch school children.
abstract: Perinatal exposure to PCBs and dioxins is associated with immune changes in healthy Dutch preschool children. To examine whether such effects persist into later childhood, we here report on the immunological effects of perinatal exposure to PCBs and dioxins in 167 Dutch children at school age. A higher postnatal PCB exposure was associated with a higher prevalence of recurrent middle ear infections and a higher prenatal PCB exposure with less shortness of breath with wheeze, as assessed by parent questionnaire. Our data indicate that, at environmental levels of these man made chemicals, subtle health effects may occur.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erasmus University and University Hospital/Sophia Children's Hospital, P.O. Box 2060, 3000 CB Rotterdam, The Netherlands. n.weisglas@erasmusmc.nl
authors.forename: Nynke
authors.initials: N
authors.lastname: Weisglas-Kuperus
authors.forename: Hestien J I
authors.initials: HJ
authors.lastname: Vreugdenhil
authors.forename: Paul G H
authors.initials: PG
authors.lastname: Mulder
mesh_terms: D002648:Child; D002675:Child, Preschool; D004147:Dioxins / Q000633:toxicity*; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006304:Health Status; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D007109:Immunity / Q000187:drug effects*; D007231:Infant, Newborn; D007239:Infections / Q000453:epidemiology; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
chemical_list: D004147:Dioxins; D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls