title: Synthesis and immunomodulatory properties of selected oxazolone derivatives.
abstract: Eleven oxazolone derivatives were synthesized and characterized by (1)H NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one (11), 4-[(E)-(4-methoxyphenyl)methylidene]-2-methyl-1,3-oxazol-5-one (12) and 4-[(E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[(E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) was found to be the most potent immunomodulator in the series.
authors.affiliation: Department of Microbiology, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Muhammad A
authors.initials: MA
authors.lastname: Mesaik
authors.forename: Shagufta
authors.initials: S
authors.lastname: Rahat
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.lastname: Zia-Ullah
authors.forename: Muhammad I
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Murad
authors.forename: Zakiah
authors.initials: Z
authors.lastname: Ismail
authors.lastname: Atta-ur-Rahman
authors.forename: Aqeel
authors.initials: A
authors.lastname: Ahmad
mesh_terms: D000818:Animals; D002417:Cattle; D002455:Cell Division; D002478:Cells, Cultured; D007155:Immunologic Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D007155:Immunologic Factors; D010080:Oxazoles