title: Sex-hormone-binding globulin is negatively correlated with femoral bone-mineral density in male cardiac-transplant recipients.
abstract: BACKGROUND
  Osteoporosis and the subsequent increase in incidence of fractures are a common problem after cardiac transplantation.
  
  
  METHODS
  We performed a cross-sectional evaluation of male cardiac-transplant recipients in a late post-transplantation period (4.2 +/- 2.6 years after cardiac transplantation, n = 21). Bone-mineral density was measured by dual-energy X-ray absorptiometry and by quantitative heel ultrasound, and the endocrine characteristics of cardiac-transplant recipients with and without vertebral fractures were investigated.
  
  
  RESULTS
  A significant negative correlation was observed between sex-hormone-binding globulin and femoral-neck bone-mineral density (rs = -0.699; p value = 0.001). Linear regression analysis controlling for age and body-mass index proved sex-hormone-binding globulin to be an independent negative predictor for femoral-neck bone-mineral density (r = -0.474; p value = 0.035). Patients with vertebral fractures had significantly lower femoral-neck bone-mineral density (pvalue = 0.035). However, sex-hormone-binding globulin, total and free testosterone, and estradiol did not exhibit significant associations with vertebral fractures in our patients.
  
  
  CONCLUSIONS
  This investigation demonstrates for the first time an association between high sex-hormone-binding globulin levels and low femoral-neck bone-mineral density in a cohort of male cardiac-transplant recipients. Our data support the important role of sex-hormone-binding globulin in the pathogenesis of post-transplantation bone disease, although--possibly because of the small number of patients--we could not prove an interrelation of sex-hormone-binding globulin with vertebral fractures.
authors.affiliation: Department of Internal Medicine, Vorarlberg Institute for Vascular Investigation and Treatment, Landeskrankenhaus Feldkirch, Feldkirch, Austria. guenter.hoefle@lkhf.at
authors.forename: Günter
authors.initials: G
authors.lastname: Höfle
authors.forename: Gerda
authors.initials: G
authors.lastname: Tautermann
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Saely
authors.forename: Heinz
authors.initials: H
authors.lastname: Drexel
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density; D015331:Cohort Studies; D005269:Femur / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D011859:Radiography; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D016103:Spinal Fractures / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D013223:Statistics as Topic
chemical_list: D012738:Sex Hormone-Binding Globulin