title: The synthesis and antibacterial activity of 3-alkyl derivatives of some pyrimido[4,5-d] pyrimidine.
abstract: The synthesis of 4,5-diamino derivatives of pyrimidine and pyrimido[4,5-d]pyrimidines is presented. The antibacterial and antifungal activity of the compounds was investigated on nine selected bacterial species, comparing the changes in the chemical structure with increase in the bioactive properties. The investigations have shown that the obtained derivatives of pyrimido[4,5-d]pyrimidines and especially the compounds reveal interesting antibacterial 6e and antifungal 6d activity.
authors.affiliation: Department of Organic Chemistry, Medical Academy, 9 Grodzka Str., 50-137 Wrocław, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Cieplik
authors.forename: Janusz
authors.initials: J
authors.lastname: Pluta
authors.forename: Olaf
authors.initials: O
authors.lastname: Gubrynowicz
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D011744:Pyrimidinones