Biosynthesis and uptake of siderophores is controlled by the PacC-mediated ambient-pH Regulatory system in Aspergillus nidulans.
Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system is elevated by an increase in the ambient pH. Mediation of this regulation by the transcriptional regulator PacC has been confirmed via acidity- and alkalinity-mimicking mutants.
Eisendle
Martin
M
Department of Molecular Biology, Medical University of Innsbruck, Austria.
Oberegger
Harald
H
Buttinger
Rudolf
R
Illmer
Paul
P
Haas
Hubertus
H
D001233:Aspergillus nidulans / Q000235:genetics / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015966:Gene Expression Regulation, Fungal / Q000235:genetics; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism; D009154:Mutation; D017262:Siderophores / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D005656:Fungal Proteins; C092394:PacC protein, Aspergillus; D017262:Siderophores; D014157:Transcription Factors; D007501:Iron