title: Acute necrotizing esophagitis: a large retrospective case series.
abstract: OBJECTIVE
  Acute necrotizing esophagitis is a rarely described entity. Its incidence has not yet been established, and its multifactorial etiology remains unknown. The aim of the present study was to establish the incidence, clinical presentation, endoscopic course, accompanying factors, and pathogenesis of the condition.
  
  
  METHODS
  A retrospective analysis of clinical, laboratory, endoscopic and histological data and the clinical course in 29 patients with acute necrotizing esophagitis was carried out over a 5-year period.
  
  
  RESULTS
  Acute necrotizing esophagitis was observed in 29 of 10 295 upper gastrointestinal endoscopies (0.28 %) carried out during the 5-year period. The average age of the patients was 75.24 years (range 40 - 91), and they were predominantly male. Eighty-three percent of the patients had comorbid conditions. In all cases, acute necrotizing esophagitis became evident with upper gastrointestinal bleeding, without hemodynamic stabilization in the majority of cases (75.9 %). The lesions predominantly affected the lower two-thirds of the esophagus (59 %), and there were coexisting abnormal endoscopic findings in 83 % of cases. Empirical supportive therapy, including oral nutritional rest, omeprazole, sucralfate (15 cases) and broad-spectrum antibiotics (7 cases) was provided. The condition resolved in all patients. Ten patients in the group died of other causes (coexisting illnesses).
  
  
  CONCLUSIONS
  Acute necrotizing esophagitis was more commonly recognized than has previously been reported. It is a serious clinical entity that should be considered in the differential diagnosis of upper gastrointestinal bleeding, particularly in elderly patients. The prognosis depends more on the patient's advanced age and on comorbid illnesses than on the course of the esophageal lesions, which resolved in all patients in this series.
authors.affiliation: Department of Gastroenterology, S Bernardo Hospital, Setúbal, Portugal.
authors.forename: F
authors.initials: F
authors.lastname: Augusto
authors.forename: V
authors.initials: V
authors.lastname: Fernandes
authors.forename: M I
authors.initials: MI
authors.lastname: Cremers
authors.forename: A P
authors.initials: AP
authors.lastname: Oliveira
authors.forename: C
authors.initials: C
authors.lastname: Lobato
authors.forename: A L
authors.initials: AL
authors.lastname: Alves
authors.forename: C
authors.initials: C
authors.lastname: Pinho
authors.forename: J
authors.initials: J
authors.lastname: de Freitas
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004941:Esophagitis / Q000209:etiology* / Q000473:pathology* / Q000628:therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome