title: A randomized comparison of clopidogrel and aspirin versus ticlopidine and aspirin after coronary stent implantation.
abstract: BACKGROUND
  The combination of a thienopyridine and aspirin has become the standard of care after intracoronary stenting. Clopidogrel appears to be better tolerated than ticlopidine but may be associated with more adverse cardiac events. We assessed the tolerability and efficacy of 2 weeks of therapy with ticlopidine and aspirin in comparison to clopidogrel and aspirin after coronary stent implantation.
  
  
  METHODS
  Patients with successful intracoronary stent implantation at our institution were randomly assigned, in addition to aspirin, to receive either ticlopidine or clopidogrel. Loading doses were administered immediately after the procedure, and the drugs were continued for 2 weeks.
  
  
  RESULTS
  Three hundred seven patients were randomly assigned: 154 patients to clopidogrel and 153 to the ticlopidine group. The primary end point of early drug discontinuation occurred in 5 patients (3.3%) in the ticlopidine group and 1 patient (0.6%) in the clopidogrel group (P =.121). Within 30 days, thrombotic stent occlusion occurred in 1 patient (0.7%) in the ticlopidine group and 3 patients (1.9%) in the clopidogrel group (P =.623). A major adverse cardiac event occurred in 3 patients (approximately 1.9%; P = 1.00) in each group.
  
  
  CONCLUSIONS
  There was a nonsignificant trend to improved tolerability of a 2-week regimen of clopidogrel and aspirin when compared with ticlopidine and aspirin in patients undergoing intracoronary stent implantation. The combination of clopidogrel and aspirin results in a comparably low incidence of major adverse cardiac events when compared with ticlopidine and aspirin.
authors.affiliation: Department of Cardiology, Liverpool Hospital, Liverpool, Australia. C.Juergens@unsw.edu.au
authors.forename: Craig P
authors.initials: CP
authors.lastname: Juergens
authors.forename: Adelina M
authors.initials: AM
authors.lastname: Wong
authors.forename: Dominic Y C
authors.initials: DY
authors.lastname: Leung
authors.forename: Harry C
authors.initials: HC
authors.lastname: Lowe
authors.forename: Sidney
authors.initials: S
authors.lastname: Lo
authors.forename: Clyne
authors.initials: C
authors.lastname: Fernandes
authors.forename: Elizabeth F
authors.initials: EF
authors.lastname: Newland
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Hopkins
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000627:therapeutic use*; D000077144:Clopidogrel; D023921:Coronary Stenosis / Q000628:therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin