title: Cutaneous benign mixed tumor (chondroid syringoma) of the eyelid: clinical presentation and management.
abstract: OBJECTIVE
  To describe the clinical presentation of cutaneous benign mixed tumor of the eyelid and its management options.
  
  
  METHODS
  Periocular cases of cutaneous benign mixed tumor were gathered from members of an oculoplastics specialty Internet discussion group. A total of 9 patients are described in this retrospective, interventional case series. The clinical presentation, histopathology, and management of these lesions is reviewed.
  
  
  RESULTS
  Patients were typically asymptomatic, presenting with a slowly enlarging, nontender nodule of 2 to 8 years' duration. The lesions ranged from 4 mm to 17 mm in greatest dimension. Four of the lesions were on the eyelid margin, three in the sub-brow area of the upper eyelid, and two in the central lids. All six cases not involving the brow were fixed to the tarsus; one brow lesion was believed to be adherent to the skin. None of the lesions was associated with significant changes of the overlying epidermis, although one lesion showed overlying pigmentation. All patients underwent excisional biopsy for diagnostic or cosmetic reasons. On histopathologic examination, the tumors were biphasic, with an epithelial component exhibiting apocrine or hair follicle differentiation and a myxoid, adipocytic, chondroid, and/or fibrous stroma. The pathologic diagnoses were all consistent with cutaneous benign mixed tumor (chondroid syringoma, pleomorphic adenoma). Follow-up ranged from 2 weeks to 12 months, although several patients failed to keep scheduled follow-up appointments. No clinical recurrences were identified.
  
  
  CONCLUSIONS
  Cutaneous benign mixed tumor may occur in the eyelid, and, although uncommon, should be included in the differential diagnosis of firm, nodular eyelid tumors. The histopathologic features are similar to those seen in this tumor type arising in other areas of the body. Preoperative consideration of this diagnostic possibility may allow the surgeon to plan for complete excision, thereby reducing the possibility of recurrence or malignant transformation.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Boston, MA, USA.
authors.forename: John T H
authors.initials: JT
authors.lastname: Mandeville
authors.forename: Joo Heon
authors.initials: JH
authors.lastname: Roh
authors.forename: John J
authors.initials: JJ
authors.lastname: Woog
authors.forename: Russell S
authors.initials: RS
authors.lastname: Gonnering
authors.forename: Peter S
authors.initials: PS
authors.lastname: Levin
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mazzoli
authors.forename: Darryl J
authors.initials: DJ
authors.lastname: Ainbinder
authors.forename: J Justin
authors.initials: JJ
authors.lastname: Older
authors.forename: Alexandre P
authors.initials: AP
authors.lastname: Moulin
authors.forename: Ralf
authors.initials: R
authors.lastname: Kiel
authors.forename: Yoon-Duck
authors.initials: YD
authors.lastname: Kim
authors.forename: Thaddeus P
authors.initials: TP
authors.lastname: Dryja
mesh_terms: D008949:Adenoma, Pleomorphic / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor