Unravelling the role of Humanin.
Humanin (HN), a recently identified neuroprotective factor against Alzheimer's disease-related insults, has been reported to function as an anti cell-death factor through multiple mechanisms. One mechanism, revealed in a glioblastoma cell line, involves the apoptosis-inducing protein Bax. This, in addition to the fact that HN is produced in certain normal tissues, such as testis, implies a potential role of HN in oncogenesis. A second mechanism, in neuronal cells, is via a putative cell-surface receptor. It is through this mechanism that HN exhibits its neuroprotective activity.
Nishimoto
Ikuo
I
Department of Pharmacology, KEIO University School of Medicine, Shinanomachi, Tokyo, Japan.
Matsuoka
Masaaki
M
niikura
Takako
T
D000544:Alzheimer Disease / Q000378:metabolism*; D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors; D017209:Apoptosis; D001923:Brain Chemistry; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D018696:Neuroprotective Agents / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors; D016415:Sequence Alignment; D051028:bcl-2-Associated X Protein
D016229:Amyloid beta-Peptides; C494826:BAX protein, human; D047908:Intracellular Signaling Peptides and Proteins; D018696:Neuroprotective Agents; D010455:Peptides; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; C427211:humanin