[Effect of a levopromazine-thymalin combination on the development of toxic edema and swelling in the brain].
The development of toxic edematous brain swelling in rats is accompanied by disproteinemia of the blood plasma and buildup of the gamma-globulin fraction. The administration of levopromazine (5 mg/kg), thymalin (1.2 mg/kg), or their combination reduces this disorder in the blood protein fractions. The antiedematous effect of the levopromazine--thymalin combination has an additive synergistic interaction.
Platonov
I A
IA
Smolensk State Medical Academy, ul. Krupskoi 28, Perm, 214019 Russia.
Vonogel'
V G
VG
Andreeva
T A
TA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001929:Brain Edema / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D008728:Methotrimeprazine / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013951:Thymus Hormones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D014150:Antipsychotic Agents; D013951:Thymus Hormones; C032805:thymalin; D008728:Methotrimeprazine