Caffeic acid phenethyl ester improves oxidative erythrocyte damage in a rat model of thermal injury.
Oxygen-derived free radicals impair cell membrane functions and induce circulatory disturbances, and free radicals, such as superoxide anion, hydrogen peroxide, hydroxyl radicals, and peroxynitrite, have been suggested to play important roles in the pathogenesis of major burn injuries. The present study investigated the effects of thermal injury on erythrocyte lipid peroxidation and antioxidant status and investigated the effects of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent, in rats subjected to thermal injury. Burn injury caused a remarkable increase in erythrocyte lipid peroxidation, levels of nitric oxide (NO), and activities of antioxidant enzymes and xanthine oxidase (XO). The treatment with CAPE decreased both activity of burn-induced XO activity and levels of NO in the erythrocytes. In conclusion, CAPE treatment resulted in decreased erythrocyte lipid peroxidation in thermal injury and helped to prevent oxidative damage by decreasing activity of XO and levels of NO.
Armutcu
Ferah
F
Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
Gürel
Ahmet
A
Hoşnuter
Mübin
M
Pabuçcu
Orhan
O
Altnyazar
Cevdet
C
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism*; D002109:Caffeic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D002374:Catalase / Q000378:metabolism; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
D000975:Antioxidants; D002109:Caffeic Acids; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D002374:Catalase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol