title: The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?
abstract: The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicate surprising genetic, physical and functional interactions between the two complexes. Although much of the existing evidence is rather preliminary in nature, these interactions might serve to coordinate the biosynthetic capacity of the cell with the function of the secretory machinery.
authors.affiliation: Department of Biology, University of Pennsylvania, 405 S. University Avenue, Philadelphia, PA 19014, USA. guowei@sas.upenn.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Peter
authors.initials: P
authors.lastname: Novick
mesh_terms: D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D005089:Exocytosis / Q000502:physiology*; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure; D008561:Membrane Fusion / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D029701:Saccharomyces cerevisiae Proteins