Diabetic cardiomyopathy.
Although the pathogenesis of diabetic cardiomyopathy is poorly understood, recent evidence implicates perturbations in cardiac energy metabolism. Whereas mitochondrial fatty acid oxidation is the chief energy source for the normal postnatal mammalian heart, the relative contribution of glucose utilization pathways is significant, allowing the plasticity necessary for steady ATP production in the context of diverse physiologic and dietary conditions. Because of the importance of insulin in the regulation of myocardial metabolism, chronic insulin deficiency or resistance results in a marked reduction in cardiac glucose utilization such that the heart relies almost exclusively on fatty acids to generate energy. High rates of fatty acid utilization in the diabetic heart could lead to functional derangements related to accumulation of lipid intermediates, excessive oxygen consumption.... Chronic derangements in myocardial cell metabolism, as well as impairment of various intracellular signalling pathways, may therefore have maladaptive consequences, including functional abnormalities.
Feuvray
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Unité mixte de recherche CNRS 8078, Université Paris-Sud XI, département de recherche médicale, hôpital Marie Lannelongue, Le Plessis-Robinson. danielle.feuvray@ibaic.upsud.fr
D055372:AMP-Activated Protein Kinases; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D008929:Mitochondria, Heart / Q000378:metabolism; D008954:Models, Biological; D009097:Multienzyme Complexes / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D018384:Oxidative Stress; D010101:Oxygen Consumption; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology
D005227:Fatty Acids; D009097:Multienzyme Complexes; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000255:Adenosine Triphosphate; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases; D005947:Glucose