title: [Clinical-biochemical parameters of blood in humans exposed to the combined effects of short-term head-down tilt and isolation].
abstract: Clinical biochemistry of blood was investigated in 6 human subjects during 7-d isolation in the head-down tilt position (HDT, -6 degrees), and in 2 subjects who also stayed in a pressurized module for 7 days but w/o motor restraint. The "dry chemistry" methods were employed to track shifts in carbohydrate, protein and lipid metabolism, plasma enzyme activity, and hemoglobin. Results of the discriminant analysis demonstrated a distinct effect after 3 d in HDT that was cancelled out by HDT day 6. Disperse analysis and Mann-Witney's Y-test revealed a considerable reduction in creatine phosphokinase and increase in triglycerides on HDT day 3. Low CPK activity was observed all the time during HDT. The control subjects displayed reduction in the aspartate aminotrasferase activity on day 3 in isolation. Clinical biochemistry of plasma remained generally within the clinical norm boundaries. All metabolic shifts were reversible and returned to baseline values after completion of the investigation. Hence, these data evidenced for functional nature of the shifts; isolation in the pressurized module did not aggravate the metabolic shifts due to adaptation to short-term HDT and ensuing readaptation.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Popova
authors.forename: T M
authors.initials: TM
authors.lastname: Sanososiuk
authors.forename: L B
authors.initials: LB
authors.lastname: Buravkova
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D006801:Humans; D018476:Hypokinesia / Q000097:blood*; D008875:Middle Aged; D012934:Social Isolation; D013997:Time Factors