title: [Peculiarities of duodenal ulcer with concomitant bronchial asthma (clinical and pathomorphological aspects)].
abstract: OBJECTIVE
  To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS.
  
  
  METHODS
  The trial covered 297 BA patients. They have undergone clinicoendoscopic examination of the gastroduodenal zone (GDZ) for duodenal ulcer with assessment of clinical gastroenterological symptoms and morphological analysis of biopsies of gastric and duodenal mucosa using histological, histochemical and morphometric methods.
  
  
  RESULTS
  BA patients were found to have high incidence of duodenal ulcer (21.9%). Morphologically, they had active immune inflammation with hyperergic component. The results of the study did not confirm the opinion about a key role of SCS in development of GDU in BA. Small doses of SCS in patients with BA and GDU do not deteriorate ulcerogenesis.
  
  
  CONCLUSIONS
  One of the factors determining combination of ulcer disease with BA may be chronic hyperergic inflammation of GDZ mucosa stimulating realization of predisposition to ulcer and its chronic recurrent course.
authors.forename: G M
authors.initials: GM
authors.lastname: Cherniavskaia
authors.forename: R I
authors.initials: RI
authors.lastname: Pleshko
authors.forename: E I
authors.initials: EI
authors.lastname: Beloborodova
authors.forename: I V
authors.initials: IV
authors.lastname: Sukhodolo
authors.forename: E V
authors.initials: EV
authors.lastname: Plekhanova
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D004381:Duodenal Ulcer / Q000209:etiology / Q000473:pathology*; D004384:Duodenoscopy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones