title: Evaluation of psychopharmacological effects of petroleum ether extract of Cuscuta reflexa Roxb. stem in mice.
abstract: The petroleum ether extract of Cuscuta reflexa Roxb. stem (PECR) was evaluated for its psychopharmacological activities in several experimental models using Swiss albino mice. The PECR was found to cause significant reduction in spontaneous activity and exploratory behavioral profiles. It also showed reduction in muscle relaxant activity by rotarod, 30 degrees inclined screen tests and showed significant analgesic properties as well as potentiated remarkably the pentobarbitone sodium, diazepam and meprobamate--induced sleeping time. All these results were compared with respective controls for the evaluation of significance. The presence of steroids in the PECR might he responsible for psychopharmacological activities.
authors.affiliation: Division of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj--757 086, Orissa, India. drdilip2003@yahoo.co.in
authors.forename: Dilipkumar
authors.initials: D
authors.lastname: Pal
authors.forename: Chinmay
authors.initials: C
authors.lastname: Panda
authors.forename: Samir
authors.initials: S
authors.lastname: Sinhababu
authors.forename: Arnab
authors.initials: A
authors.lastname: Dutta
authors.forename: Shiladitya
authors.initials: S
authors.lastname: Bhattacharya
mesh_terms: D000473:Alkanes / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D034182:Cuscuta; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D011600:Psychopharmacology; D012890:Sleep / Q000187:drug effects
chemical_list: D000473:Alkanes; D010936:Plant Extracts; C004544:naphtha