title: Salivary production of IgA and IgG to human herpes virus 8 latent and lytic antigens by patients in whom Kaposi's sarcoma has regressed.
abstract: IgG and IgA antibodies with specificities to a latent and a lytic antigen of human herpes virus 8 (HHV-8) were detectable in the saliva and serum of eight patients whose Kaposi's sarcoma had regressed, seven of whom were HIV-1 infected. The measurement of antibody-specific activity and secretion rate, and the detection of secretory IgA all indicate anti-HHV-8 antibody activity in saliva. The specific humoral responses possibly influence mucosal replication of HHV-8, and in turn, that of HIV.
authors.affiliation: Department of Oral Medicine, Eastman Institute for Oral Health Care Sciences, University College London, London, UK.
authors.forename: Francois-Xavier
authors.initials: FX
authors.lastname: Mbopi-Keou
authors.forename: Jerome
authors.initials: J
authors.lastname: Legoff
authors.forename: Christophe
authors.initials: C
authors.lastname: Piketty
authors.forename: Hakim
authors.initials: H
authors.lastname: Hocini
authors.forename: Jean-Elie
authors.initials: JE
authors.lastname: Malkin
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
authors.forename: Crispian M
authors.initials: CM
authors.lastname: Scully
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Porter
authors.forename: Chong-Gee
authors.initials: CG
authors.lastname: Teo
authors.forename: Laurent
authors.initials: L
authors.lastname: Belec
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D007074:Immunoglobulin G / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*; D012514:Sarcoma, Kaposi / Q000378:metabolism*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G