Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus.
An 82-kb Aspergillus parasiticus genomic DNA region representing the completed sequence of the well-organized aflatoxin pathway gene cluster has been sequenced and annotated. In addition to the 19 reported and characterized aflatoxin pathway genes and the four sugar utilization genes in this cluster, we report here the identification of six newly identified genes which are putatively involved in aflatoxin formation. The function of these genes, the cluster organization and its significance in gene expression are discussed.
Yu
Jiujiang
J
U.S. Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, 1100 Robert E. Lee Boulevard, New Orleans, LA 70124, USA. jiuyu@srrc.ars.usda.gov
Bhatnagar
Deepak
D
Cleveland
Thomas E
TE
D000348:Aflatoxins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D001230:Aspergillus / Q000235:genetics*; D001483:Base Sequence; D016386:Chromosome Walking; D004798:Enzymes / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D005800:Genes, Fungal / Q000235:genetics; D016681:Genome, Fungal; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*
D000348:Aflatoxins; D004798:Enzymes