Biocatalytic and biomimetic aminolysis reactions: useful tools for selective transformations on polyfunctional substrates.
Aminolysis is a deeply studied reaction, but the development of new catalysts for this process is still an emerging area of organic and bioorganic chemistry. Two different approaches are reviewed in this article: the biomimetic de novo designed synthetic catalysts and the use of natural enzymes. Brief mechanistic considerations are discussed. Some important aspects like chemo-, regio- and stereoselectivity towards the substrates are highlighted on selected examples with synthetic applications.
Alfonso
Ignacio
I
Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/ Julián Clavería, 8, E-33071 Oviedo, Spain.
Gotor
Vicente
V
D000581:Amidohydrolases / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D032701:Biomimetics; D002384:Catalysis; D010450:Endopeptidases / Q000737:chemistry; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry; D010399:Penicillin Amidase / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000588:Amines; D004798:Enzymes; D009842:Oligopeptides; D010450:Endopeptidases; D000581:Amidohydrolases; D010399:Penicillin Amidase