title: Arterial blood gases with 700 ml tidal volumes during out-of-hospital CPR.
abstract: The optimal tidal and minute ventilation during cardiopulmonary resuscitation (CPR) is not known. In the present study seven adult, non-traumatic, out-of-hospital cardiac arrest patients were intubated and mechanically ventilated at 12 min(-1) with 100% oxygen and a tidal volume of 700 ml (10 +/- 2 ml kg(-1)). Arterial blood gas samples were analysed after 6-8 min of unsuccessful resuscitation and mechanical ventilation. Mean PaCO2 was 5.2 +/- 1.3 kPa and mean PaO2 30.7 +/- 17.2 kPa. The patient with the highest (14 ml kg(-1)) and lowest (8 ml kg(-1)) tidal volumes per kg had the lowest and highest PaCO2 values of 2.6 and 6.8 kPa, respectively. Linear regression analysis confirmed a significant correlation between arterial pCO2 and tidal volume in ml/kg, r2 = 0.87. We conclude that aiming for an estimated ventilation of 10 ml kg(-1) tidal volume at frequency of 12 min(-1) might be expected to achieve normocapnia during ALS.
authors.affiliation: Norwegian Air Ambulance, Drøbak, Norway. elizabeth@nakos.org
authors.forename: E
authors.initials: E
authors.lastname: Dorph
authors.forename: L
authors.initials: L
authors.lastname: Wik
authors.forename: P A
authors.initials: PA
authors.lastname: Steen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries; D002245:Carbon Dioxide / Q000097:blood*; D016887:Cardiopulmonary Resuscitation / Q000379:methods; D004632:Emergency Medical Services / Q000379:methods; D005260:Female; D006323:Heart Arrest / Q000628:therapy; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D012121:Respiration, Artificial; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen