title: Investigation of racemisation in peptide synthesis within a micro reactor.
abstract: We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.
authors.affiliation: Department of Chemistry, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
authors.forename: Paul
authors.initials: P
authors.lastname: Watts
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wiles
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Haswell
authors.forename: Esteban
authors.initials: E
authors.lastname: Pombo-Villar
mesh_terms: D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D007202:Indicators and Reagents; D010455:Peptides