[Morphologic and morphometric characteristics of the femoral head in experimental necrosis and after incomplete occlusion of the femoral artery].
Partial occlusion (by 70-80%) of the femoral artery (FA) below its bifurcation with the deep femoral one was created in 15 dogs 6 months after modeling of aseptic necrosis of femoral head (FH). The dynamics of local circulation was evaluated using the methods of hydrogen clearance, angiography, flowmetry, polarography and mingography. FA and neighboring vessels as well as FH bone tissue were studied using histological, histochemical and morphometric methods. It was found that partial occlusion of FA below its bifurcation with the deep femoral branch resulted after 180-240 days in a redistribution of blood flow in favor of the latter along with a formation of collateral vessel widening as well as in the change in the circulation vector in the direction of the hip joint. This contributed to FH revascularization after modeling of its traumatic aseptic necrosis. The results of the morphological analysis indicate the activation of osteogenesis and gradual replacement of the necrotic area in FH with a newly formed osseous tissue and are suggestive of possible application of this method for clinical use.
Rasulov
R M
RM
Russian R.R. Vreden Scientific Research Institute of Traumatology and Orthopedics and Scientific Research Center, I.P. Pavlov State Medical University, St. Petersburg.
Kornilov
N V
NV
Bol'shakov
O P
OP
Titova
A T
AT
Tashaev
Sh S
ShS
Zaĭtseva
M Iu
MIu
Aganezov
S A
SA
Bolobovko
A E
AE
D000818:Animals; D003097:Collateral Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000473:pathology*; D005270:Femur Head / Q000098:blood supply / Q000473:pathology*; D005271:Femur Head Necrosis / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology