title: [Comparison of different MRI sequences with and without application of Gd-BOPTA as follow-up after LITT].
abstract: OBJECTIVE
  Comparison of various MR imaging techniques without and with the application of Gd-BOPTA for the follow-up of thermal tumor ablations by means of laser-induced therapy (LITT).
  
  
  METHODS
  Thermal tumor ablations were performed with LITT in 19 patients showing a local recurrence. The metastases were from colorectal carcinoma in 15 cases (78.9 %) and from cervix, bronchial, gastric and renal carcinoma respectively in one patient each. The size of the metastases before ablation was on average 38.5 mm (min = 25 mm, max = 58 mm). The MRI protocol consisted of T2 UTSE FS, T1 w GRE without and with Gd-BOPTA at an early (20 s post injection) and late stage (> 120 min post injection). Two independent radiologists evaluated image contrast of the local relapse and necrosis in comparison to the surrounding healthy liver parenchyma on a scale from - 10 to + 10. Liver parenchyma was in any sequence 0. Recurrences were confirmed with follow-up examinations in all patients. Statistical analysis was performed by means of Wilcoxon and Kendall's W-test.
  
  
  RESULTS
  Both radiologists found absolute ratios for contrast differences between thermal necrosis and local recurrence, with an average of 10.95 for T2 w UTSE FS and of 6.58 for T1 w GRE without, and of 4.05 for T1 w GRE with Gd-BOPTA in the early and of 2.26 in the late stage. Superiority for UTSE FS was significant (p < 0.05). The statistical analysis showed a high agreement for both radiologists for all values (p < 0.001).
  
  
  CONCLUSIONS
  For early detection of local recurrences after thermal ablation T2 w UTSE FS is most suitable. For the detection of new foci, the use of liver specific contrast media is advisable.
authors.affiliation: Klinik für Strahlenheilkunde, Charité Virchow-Klinikum, Humboldt Universität zu Berlin. maciej.pech@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Pech
authors.forename: B
authors.initials: B
authors.lastname: Spors
authors.forename: G
authors.initials: G
authors.lastname: Wieners
authors.forename: G
authors.initials: G
authors.lastname: Warschewske
authors.forename: A
authors.initials: A
authors.lastname: Beck
authors.forename: C
authors.initials: C
authors.lastname: Cho
authors.forename: F
authors.initials: F
authors.lastname: Fischbach
authors.forename: J
authors.initials: J
authors.lastname: Ricke
mesh_terms: D003287:Contrast Media; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009942:Organometallic Compounds; D011785:Quality Assurance, Health Care
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine