TBAF-catalyzed synthesis of 5-substituted 1H-tetrazoles under solventless conditions.
Tetrabutylammonium fluoride (TBAF) is an efficient catalyst in the [3 + 2] cycloaddition reaction of organic nitriles 1 with trimethylsilyl azide (TMSN(3)) in solventless conditions. The corresponding 5-substituted 1H-tetrazoles 2 were obtained under mild conditions and in 80-97% yields.
Amantini
David
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Dipartimento di Chimica, Laboratorio di Chimica Organica, Università di Perugia, CEMIN (Centro di Eccellenza Materiali Innovativi per applicazioni chimiche, fisiche e biomediche), via Elce di Sotto 8, I-06123 Perugia, Italy.
Beleggia
Romina
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Fringuelli
Francesco
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Pizzo
Ferdinando
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Vaccaro
Luigi
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