Polymorphisms of glutathione S-transferases M1 and T1 do not account for interindividual differences for smoking behavior.
To identify whether the polymorphisms of glutathione S-transferase M1 (GSTM1) and GSTT1 genes predict a high-tended risk of using tobacco, the GSTM1 and GSTT1 genotypes of 369 Iranian males (254 nonsmokers and 115 smokers) and 314 Iranian females (245 nonsmokers and 69 smokers) were determined. The frequencies of GSTM1 (males: OR=0.98, 95% CI=0.62-1.57, P=.974; females: OR=1.34, 95% CI=0.75-2.39, P=.358) and GSTT1 (males: OR=1.25, 95% CI=0.76-2.04, P=.412; females: OR=0.84, 95% CI=0.46-1.51, P=.626) null genotypes were similar in nonsmokers and smokers. The risk of being a smoker was to be equally frequent in each combination of the genotypes. The present results revealed that there was no difference between smokers and nonsmokers for these two genetic polymorphisms.
Saadat
Mostafa
M
Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran. saadat@susc.ac.ir
Mohabatkar
Hassan
H
D000328:Adult; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D012907:Smoking / Q000235:genetics* / Q000378:metabolism / Q000523:psychology
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1