Cortical activation changes associated with motor recovery in patients with precentral knob infarct.
We investigated the cortical activation changes associated with motor recovery in six hemiparetic patients with precentral knob infarct. fMRI at 1.5 T with finger movements at a fixed rate was performed twice in each patient, 1 and 6 months after stroke onset. From the images obtained, the LI (laterality index) for the primary sensorimotor cortex (SM1) was calculated to measure the degree of the cortical activity concentration in the contralateral hemisphere. Our results showed that a greater improvement in motor function scores was significantly correlated with a greater increment in LI induced by affected finger movements (p < 0.05). Motor recovery after precentral knob infarct was found to be positively related with the concentration of SM1 activity in the ipsilesional hemisphere. This finding may imply motor recovery through cortical reorganization after precentral knob infarct in the human brain.
Jang
Sung Ho
SH
Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University 317-1, Daemyungdong, Namku, Taegu, 705-717, Republic of Korea. strokerehab@hanmail.net
Cho
Sang-Hyun
SH
Kim
Yun-Hee
YH
Kwon
Yong-Hyun
YH
Byun
Woo Mok
WM
Lee
Se Jin
SJ
Park
Sung Min
SM
Chang
Chul Hoon
CH
D000368:Aged; D002540:Cerebral Cortex / Q000502:physiology*; D002544:Cerebral Infarction / Q000150:complications / Q000503:physiopathology*; D005385:Fingers / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010291:Paresis / Q000209:etiology / Q000503:physiopathology
D010100:Oxygen