The talin wags the dog: new insights into integrin activation.
Integrin transmembrane receptors have a unique property that distinguishes them from other signaling receptors. Their affinity for ligands can be modulated from the inside out in response to intracellular signals generated by non-integrin receptors. Recent findings provide novel mechanistic insights into this process by demonstrating that talin, a protein that links integrins to actin, is necessary for the inside-out activation of integrins.
Cram
Erin J
EJ
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.
Schwarzbauer
Jean E
JE
D008841:Actin Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008024:Ligands; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation; D015398:Signal Transduction / Q000502:physiology; D016608:Talin / Q000378:metabolism*
D016023:Integrins; D008024:Ligands; D016608:Talin