A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan.
In this paper a compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration. The activity of topotecan in defined buffers is first modelled using a linear two compartment model that then forms the basis of a cell based model for drug activity in live cell experiments. An identifiability analysis is performed before parameter estimation to ensure that the model output (i.e., continuous, perfect and noise-free data) uniquely determines the parameters. Parameter estimation is performed using experimental data which offers concentrations of active and inactive forms of topotecan from high performance liquid chromatography methods.
Evans
Neil D
ND
School of Engineering, University of Warwick, Coventry CV4 7AL, UK.
Errington
Rachel J
RJ
Shelley
Michael
M
Feeney
Graham P
GP
Chapman
Michael J
MJ
Godfrey
Keith R
KR
Smith
Paul J
PJ
Chappell
Michael J
MJ
D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002451:Cell Compartmentation; D003198:Computer Simulation; D004334:Drug Administration Schedule; D006801:Humans; D008954:Models, Biological; D019772:Topotecan / Q000493:pharmacokinetics*
D000970:Antineoplastic Agents; D019772:Topotecan