Incorporation of isoniazid into liposomes with different lipid composition.
Liposomes containing isoniazid were obtained by extrusion of multilamellar phospholipid vesicles containing isoniazid, by ultrasound treatment, and from proliposomes. Optimal conditions for isolation of stable liposomes (200 nm in diameter) and the amount of incorporated isoniazid were determined by varying concentrations of phospholipids and isoniazid and by changing phospholipid composition.
Sorokoumova
G M
GM
M. V. Lomonosov Moscow State Academy of Fine Chemical Technology.
Selishcheva
A A
AA
Malikova
N M
NM
Minina
A S
AS
Shvets
V I
VI
D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000032:analysis / Q000494:pharmacology; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000032:analysis / Q000494:pharmacology; D008081:Liposomes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010743:Phospholipids / Q000032:analysis / Q000737:chemistry; D014376:Tuberculosis / Q000188:drug therapy
D000995:Antitubercular Agents; D008081:Liposomes; D010743:Phospholipids; D007538:Isoniazid