title: New cytotoxic metabolites from a marine sponge Homaxinella sp.
abstract: Three new butenolides (1-3), a new cyclopentenone derivative (4), and a known alcohol (5) were isolated from a marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analyses. The stereochemistry of the butenolides and cyclopentenone derivative was defined on the basis of optical rotation and CD spectroscopy. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed marginal to significant activity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Tayyab A
authors.initials: TA
authors.lastname: Mansoor
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Chung Ja
authors.initials: CJ
authors.lastname: Sim
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Dong Seok
authors.initials: DS
authors.lastname: Lee
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000438:Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: C486280:(2Z,5Z,8Z)-tetradeca-2,5,8-trien-1-ol; D000438:Alcohols; D000970:Antineoplastic Agents; D003517:Cyclopentanes; D005663:Furans; C486275:homaxinolide A; C486277:homaxinolide B; C486278:homaxinolide C; C486279:homaxinone A