title: Effect of opiate peptide dalargin and des-Tyr-dalargin on cardiac pump function during ischemia-reperfusion.
abstract: Experiments on isolated perfused rat heart showed that nonselective micro- and delta-opiate receptor agonist dalargin decreased contractility of the intact heart, but had no effect on pump function of the ischemic myocardium. Dalargin analogue des-Tyr-dalargin not binding to opiate receptors decreased contractility of intact myocardium and isolated heart exposed to 45-min total ischemia. We hypothesize that the influence of dalargin is related to activation of cardiac delta-opiate receptors, while the inotropic effect of des-Tyr-dalargin is mediated by other receptors.
authors.affiliation: Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk.
authors.forename: T V
authors.initials: TV
authors.lastname: Lasukova
authors.forename: L N
authors.initials: LN
authors.lastname: Maslov
authors.forename: Yu K
authors.initials: YK
authors.lastname: Podoksenov
authors.forename: A Yu
authors.initials: AY
authors.lastname: Podoksenov
authors.forename: A A
authors.initials: AA
authors.lastname: Platonov
authors.forename: M V
authors.initials: MV
authors.lastname: Ovchinnikov
authors.forename: Zh D
authors.initials: ZhD
authors.lastname: Bespalova
mesh_terms: D000818:Animals; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D015427:Reperfusion Injury / Q000503:physiopathology*; D017725:Ventricular Pressure / Q000187:drug effects / Q000502:physiology
chemical_list: C497517:dalargin, destyrosyl-; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-