Deoxypodophyllotoxin reduces skin pigmentation of brown Guinea pigs.
In this report, we have demonstrated that deoxypodophyllotoxin from Anthriscus sylvestris (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.
Choi
Hyunjung
H
Skin Research Institute, R and D Center, Amore-Pacific Corp., Kyounggi-do, Korea.
Lee
Jeongho
J
Shin
Hyun-Jung
HJ
Lee
Byeong-Gon
BG
Chang
Ihseop
I
Hwang
Jae-Sung
JS
D000279:Administration, Cutaneous; D000818:Animals; D019661:Apiaceae; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal; D006168:Guinea Pigs; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D012880:Skin Pigmentation / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
D003879:Dermatologic Agents; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C014451:deoxypodophyllotoxin; D011034:Podophyllotoxin