title: Lymphedema associated with sirolimus in renal transplant recipients.
abstract: Lymphoceles are common in renal transplant recipients who receive sirolimus (SRL). However, a recent MEDLINE search revealed no reports of lymphedema related to SRL. We describe three cases of lymphedema that resolved or improved on discontinuation of SRL. No other likely causes of lymphedema were discovered. Recognizing the association may lead to early discontinuation of SRL, which may prevent permanent disfigurement. It may also prevent unnecessary investigations. The mechanisms of this phenomenon are not clear. We hypothesize that increased lymph flow along with disrupted lymphatics in the affected extremities may explain this complication of SRL. Further studies are necessary to confirm our findings.
authors.affiliation: Division of Nephrology, Indiana University Medical Center, Indianapolis, Indiana 46202, USA.
authors.forename: Walid
authors.initials: W
authors.lastname: Aboujaoude
authors.forename: Martin L
authors.initials: ML
authors.lastname: Milgrom
authors.forename: Mahendra V
authors.initials: MV
authors.lastname: Govani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008209:Lymphedema / Q000139:chemically induced*; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus