title: Efficient C-H/C-D exchange reaction on the alkyl side chain of aromatic compounds using heterogeneous Pd/C in D2O.
abstract: [reaction: see text] An efficient and extensive deuterium incorporation using heterogeneous Pd/C-D(2)O-H(2) system into many different types of unactivated C-H bond positions was developed. The present method provides a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D(2)O media.
authors.affiliation: Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan. sajiki@gifu-pu.ac.jp
authors.forename: Hironao
authors.initials: H
authors.lastname: Sajiki
authors.forename: Fumiyo
authors.initials: F
authors.lastname: Aoki
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Esaki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maegawa
authors.forename: Kosaku
authors.initials: K
authors.lastname: Hirota