Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi.
During a Plasmodium chabaudi infection in interleukin-10 (IL-10) knockout mice, there is greater parasite sequestration, more severe cerebral edema, and a high frequency of cerebral hemorrhage compared with infection of C57BL/6 mice. Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice.
Sanni
Latifu A
LA
Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
Jarra
William
W
Li
Ching
C
Langhorne
Jean
J
D000818:Animals; D001929:Brain Edema / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005260:Female; D016753:Interleukin-10 / Q000172:deficiency* / Q000235:genetics; D016779:Malaria, Cerebral / Q000150:complications / Q000209:etiology* / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D016788:Plasmodium chabaudi / Q000472:pathogenicity; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10