Antigenotoxic effect of allicin against SCEs induced by methyl methanesulphonate in cultured mammalian cells.
Allicin, one of the sulphur compounds of garlic (Allium sativum), possesses antioxidant and thiol disulphide exchange activity and is also shown to cause a variety of activities potentially useful for human health. In this investigation, the effect of 1,5,10 and 20 microM of allicin was determined for inhibiting the rate of SCE induced by 60 microM of MMS. Cultured human lymphocytes from two female donors were used for the experiment. The levels of SCEs were lowered by allicin suggesting its antigenotoxic activity in mammalian cells in vitro.
Siddique
Yasir Hasan
YH
Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202 001, India.
Afzal
Mohammad
M
D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects*; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D004220:Disulfides; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008741:Methyl Methanesulfonate / Q000009:adverse effects*; D009153:Mutagens / Q000009:adverse effects*; D012854:Sister Chromatid Exchange; D013441:Sulfinic Acids / Q000494:pharmacology*
D018906:Antineoplastic Agents, Alkylating; D000975:Antioxidants; D004220:Disulfides; D009153:Mutagens; D013441:Sulfinic Acids; C006452:allicin; D008741:Methyl Methanesulfonate