title: Cutaneous T-cell lymphoma in a 21-year-old male with Wolf-Hirschhorn syndrome.
abstract: We describe a case of cutaneous T-cell lymphoma occurring in a 21-year-old male with Wolf-Hirschhorn syndrome (WHS) due to a chromosome 4p16.3 deletion. This is the first documented case report of malignancy occurring in an adult with WHS. We also review the literature regarding patients with WHS and the joint occurrence of malignancy and discuss genetic changes involving chromosome 4 which may have contributed to the genesis of our patient's lymphoma.
authors.affiliation: William Beaumont Hospital, Department of Pediatrics, Royal Oak, Michigan.
authors.forename: Beau
authors.initials: B
authors.lastname: Batton
authors.affiliation: William Beaumont Hospital, Department of Hematology and Oncology, Royal Oak, Michigan.
authors.forename: Adoor
authors.initials: A
authors.lastname: Amanullah
authors.affiliation: William Beaumont Hospital, Department of Hematology and Oncology, Royal Oak, Michigan.
authors.forename: Charles
authors.initials: C
authors.lastname: Main
authors.affiliation: Henry Ford Health System, Department of Dermatology, Detroit, Michigan.
authors.forename: David
authors.initials: D
authors.lastname: Fivenson
authors.affiliation: William Beaumont Hospital, Department of Hematology and Oncology, Royal Oak, Michigan.
authors.forename: Samir
authors.initials: S
authors.lastname: Jamil
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics; D000328:Adult; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000150:complications* / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D004817:Epidermis / Q000473:pathology; D006801:Humans; D007120:Immunochemistry; D008214:Lymphocytes / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D017731:Lymphomatoid Papulosis / Q000473:pathology; D008297:Male; D013577:Syndrome