title: Rising prevalence of HIV-1 non-B subtypes in Belgium: 1983-2001.
abstract: This study documented the HIV-1 subtype distribution in 2 Belgian hospitals and determined predictive demographics for non-B subtypes. Overall, subtype B was the most prevalent subtype in this population, followed by subtypes A and C. Several recombinants were detected, circulating recombinants as well as new ones. We found a rise in non-B subtypes from 0% in 1983 to 57% in 2001. The Cochran-Armitage trend test (P < 0.001) as well as the correlation analysis (R = 0.71, P = 0.0006) was highly significant. Recombinants were also increasing in this patient population from 0% in 1983 to 10% in 2001, with good support from the statistical analyses (trend test P < 0.001; correlation analysis R = 0.67, P = 0.0016). Heterosexual route of infection, black African race, African origin of the virus, and year of diagnosis were predictors for infection with non-B subtypes in multivariate analysis. This analysis indicates that the prevalence of non-B subtypes and recombinants in this patient population is high and increasing. Gathering demographic and sequence information from newly diagnosed patients could be useful to further follow the spread of non-B subtypes in Belgium and Europe, but subtyping based on sequence information still remains the most reliable method.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
authors.forename: Joke
authors.initials: J
authors.lastname: Snoeck
authors.forename: Kristel
authors.initials: K
authors.lastname: Van Laethem
authors.forename: Philippe
authors.initials: P
authors.lastname: Hermans
authors.forename: Eric
authors.initials: E
authors.lastname: Van Wijngaerden
authors.forename: Inge
authors.initials: I
authors.lastname: Derdelinckx
authors.forename: Yoeri
authors.initials: Y
authors.lastname: Schrooten
authors.forename: David A M C
authors.initials: DA
authors.lastname: van de Vijver
authors.forename: Stéphanie
authors.initials: S
authors.lastname: De Wit
authors.forename: Nathan
authors.initials: N
authors.lastname: Clumeck
authors.forename: Anne-Mieke
authors.initials: AM
authors.lastname: Vandamme
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000145:classification / Q000453:epidemiology*; D000328:Adult; D001530:Belgium / Q000453:epidemiology; D005260:Female; D005843:Geography; D015658:HIV Infections / Q000145:classification / Q000453:epidemiology*; D015497:HIV-1 / Q000145:classification* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D044469:Racial Groups; D012725:Sexual Behavior