title: IgA deficiency: clinical correlates and responses to pneumococcal vaccine.
abstract: We surveyed historical and laboratory data for 127 IgA-deficient patients (ages 2-67), referred to an immunology clinic; the commonest medical history was recurrent respiratory infections (50%), followed by autoimmunity (28%) asthma and allergy (13%). Fifty-two subjects have been given a pneumococcal vaccination; vaccine responses to 12 serotypes were significantly related to serum IgG2 levels (P = 0.004). Six immunized IgA/IgG2-deficient subjects produced insignificant amounts of antibodies to these pneumococcal serotypes; 10 others with normal IgG2 levels also had subnormal vaccine responses. IgA-deficient patients who had at least one B8 allele (n = 19) had a significantly greater response to this vaccine than the HLA-B8-negative subjects (n = 24) (P = 0.024). There was no relationship between a history of recurring infections and pneumococcal vaccine responses; HLA status was not related to a history of autoimmunity.
authors.affiliation: Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Eki
authors.initials: E
authors.lastname: Edwards
authors.forename: Samiya
authors.initials: S
authors.lastname: Razvi
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cunningham-Rundles
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D015795:HLA-B8 Antigen / Q000235:genetics*; D006801:Humans; D017098:IgA Deficiency / Q000276:immunology*; D017099:IgG Deficiency / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000276:immunology*; D012737:Sex Factors
chemical_list: D000914:Antibodies, Viral; D006680:HLA Antigens; D015795:HLA-B8 Antigen; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines