The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?
The translocon is responsible for the translocation of proteins across the membrane of the endoplasmic reticulum into its lumen, whereas the exocyst acts at the other end of the secretory pathway, tethering secretory vesicles to the sites of exocytosis. Here, we discuss three independent lines of evidence that indicate surprising genetic, physical and functional interactions between the two complexes. Although much of the existing evidence is rather preliminary in nature, these interactions might serve to coordinate the biosynthetic capacity of the cell with the function of the secretory machinery.
Guo
Wei
W
Department of Biology, University of Pennsylvania, 405 S. University Avenue, Philadelphia, PA 19014, USA. guowei@sas.upenn.edu
Novick
Peter
P
D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D005089:Exocytosis / Q000502:physiology*; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure; D008561:Membrane Fusion / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins / Q000096:biosynthesis / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism / Q000648:ultrastructure
D029701:Saccharomyces cerevisiae Proteins