In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand.
The susceptibility of 20 isolates of Plasmodium vivax on the Thailand-Myanmar border to seven antimalarial drugs was evaluated using the schizont maturation inhibition technique. The geometric mean 50% inhibition concentration (IC(50)) values were quinine = 308 ng/mL, amodiaquine =14 ng/mL, chloroquine =50 ng/mL, mefloquine = 127 ng/mL, sulfadoxine/pyrimethamine (80:1) = 800/10 ng/mL, pyrimethamine = 8 ng/mL, and artesunate = 0.5 ng/mL. Compared with P. falciparum in this area, P. vivax was more sensitive to chloroquine and artesunate, equally sensitive to quinine, and more resistant to mefloquine.
Chotivanich
Kesinee
K
Faculty of Tropical Medicine, and Department of Pathobiology, Mahidol University, Bangkok, Thailand.
Udomsangpetch
Rachanee
R
Chierakul
Wirongrong
W
Newton
Paul N
PN
Ruangveerayuth
Ronatrai
R
Pukrittayakamee
Sasithon
S
Looareesuwan
Sornchai
S
White
Nicholas J
NJ
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004351:Drug Resistance; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D020128:Inhibitory Concentration 50; D016780:Malaria, Vivax / Q000097:blood / Q000469:parasitology; D010966:Plasmodium vivax / Q000187:drug effects* / Q000302:isolation & purification; D018709:Statistics, Nonparametric; D013785:Thailand
D000962:Antimalarials