title: QSAR study on phenolic activity: need of positive hydrophobic term (log P) in QSAR.
abstract: The phenolic activity (log 1/C) of a large series of phenols against L1210 leukaemia cells was modelled using physicochemical parameters other than conventional electronic and steric parameters. Attempts have also been made to examine need or otherwise of the hydrophobic parameter, log P, in such studies. The results have shown that contribution of log P in modelling log 1/C is favourable.
authors.affiliation: Department of Chemistry, Soft Vision College of Biotechnology and Science, 7, Green pank Colony, Indore 452001, India.
authors.forename: Mamta
authors.initials: M
authors.lastname: Thakur
authors.forename: Alok
authors.initials: A
authors.lastname: Agarwal
authors.forename: Abhilash
authors.initials: A
authors.lastname: Thakur
authors.forename: Padmakar V
authors.initials: PV
authors.lastname: Khadikar
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000473:pathology; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D010636:Phenols