[Dependence of nitric oxide level in blood on the degree of damage in coronary vessels in women younger than 55 years with ischemic heart disease].
OBJECTIVE
To estimate content of nitric oxide (NO) metabolites in women under 55 years with reference to affection of coronary vessels as shown by coronaroangiography (CAG).


METHODS
A case-control study included 32 women under 55 years of age with verified coronary heart disease (CHD) and matched controls. The blood of the examinees was tested for NO metabolites--nitrites and nitrates--according to N. E. Emchenko technique.


RESULTS
Subnormal levels of nitrites and nitrates were found both in angina pectoris and myocardial infarction, in unaffected coronary vessels as well. In atherosclerotic coronary vessels NO metabolites' concentrations were the lowest. A significant negative correlation was found between the magnitude of nitrates reduction and the number of atherosclerosis-affected coronary vessels.


CONCLUSIONS
Women under 55 years of age suffering from IHD (any type of coronary affection) had significantly lowered blood levels of NO metabolites compared to healthy women.
Vardugina
N G
NG
Volkova
E G
EG
Orlova
N S
NS
D000328:Adult; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000473:pathology; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood*; D009573:Nitrites / Q000097:blood
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide