title: Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains.
abstract: Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.
authors.affiliation: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, 2078 Graves Hall, 333 West 10th Ave., Columbus, OH 43210-1239, USA. pappenfuss.1@osu.edu
authors.forename: Tracey L
authors.initials: TL
authors.lastname: Papenfuss
authors.forename: Connie J
authors.initials: CJ
authors.lastname: Rogers
authors.forename: Ingrid
authors.initials: I
authors.lastname: Gienapp
authors.forename: Maria
authors.initials: M
authors.lastname: Yurrita
authors.forename: Melanie
authors.initials: M
authors.lastname: McClain
authors.forename: Nicole
authors.initials: N
authors.lastname: Damico
authors.forename: Janie
authors.initials: J
authors.lastname: Valo
authors.forename: Fei
authors.initials: F
authors.lastname: Song
authors.forename: Caroline C
authors.initials: CC
authors.lastname: Whitacre
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002369:Castration; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D015994:Incidence; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D010052:Ovariectomy; D012720:Severity of Illness Index; D012727:Sex Characteristics; D013045:Species Specificity