title: Brain metastases in hepatoblastoma.
abstract: Brain metastases from hepatoblastomas are rare. We report a 2-year-old male who developed multiple hemorrhagic intracranial metastases. Previous reports indicate that brain metastases are an almost uniformly fatal complication of hepatoblastoma, although one long-term survivor has been described. In a child with known hepatoblastoma, the development of neurologic signs or symptoms should lead to the performance of a brain imaging study to exclude the possibility of intracranial extension of the disease.
authors.affiliation: Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York City, New York 10021, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Begemann
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Trippett
authors.forename: Eric
authors.initials: E
authors.lastname: Lis
authors.forename: Nuno L
authors.initials: NL
authors.lastname: Antunes
mesh_terms: D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005500:Follow-Up Studies; D018197:Hepatoblastoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007223:Infant; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D009778:Occipital Lobe / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed