title: Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.
abstract: It is generally believed that multiple Ca2+ stores are present in cells, a notion that has now been made substantive by the discovery of multiple Ca2+ mobilizing messengers. Cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP) are two such messengers that are derived from NAD and NADP, respectively. A wide variety of cells, from plants to mammals, including human, have been shown to be responsive to these two novel Ca2+ messengers. Not only are their structures and mechanisms of action different, their targeted Ca2+ stores are also distinct and separable. This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP.
authors.affiliation: University of Minnesota, Department of Pharmacology, Minneapolis, MN 55455, USA. leehc@maroon.tc.umn.edu
authors.forename: Hon Cheung
authors.initials: HC
authors.lastname: Lee
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002384:Catalysis; D036563:Cyclic ADP-Ribose / Q000378:metabolism*; D006801:Humans; D009249:NADP / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D036563:Cyclic ADP-Ribose; D009249:NADP; C024376:NAADP; D002118:Calcium