[A case of primary small cell carcinoma in the common bile duct].
Extrapulmonary primary small cell carcinoma comprises approximately 4% of all small cell carcinoma. In the common bile duct, small cell carcinomas are extremely rare. We experienced a 60-year-old woman with small cell carcinoma arising in the common bile duct. Abdominal CT scan revealed an intraluminal mass in the proximal common bile duct and multiple lymphadenopathies. Microscopic examination of the tumor revealed proliferation of small monotonous anaplastic cells, which were characterized with hyperchromatic nuclei, high nuclear to cytoplasmic ratio, and frequent mitosis. By immunohistochemical stain, the tumor cells were strongly positive for chromogranin, synaptophysin, and CD56. We report this case with a review of literatures.
Park
Hea Won
HW
Department of Internal Medicine, Keimyung University College of Medicine, Dongsan Medical Center, 194 Dongsan-dong, Jung-gu, Daegu 700-712, Korea.
Seo
Sang Hyuck
SH
Jang
Byoung Kuk
BK
Hwang
Jun Young
JY
Park
Kyung Sik
KS
Cho
Kwang Bum
KB
Hwang
Jae Seok
JS
Ahn
Sung Hoon
SH
Kang
Koo Jeong
KJ
Kang
Yu Na
YN
Kim
Gab Chul
GC
D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D003138:Common Bile Duct Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged