Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity.
The parkinsonian symptoms of primates after MPTP exposure can be measured by several visual methods (classical motor scores). However, these methods have a subjective bias, especially as regards the evaluation of the motor activity. Computerized monitoring systems represent an unbiased method for measuring the motor disability of monkeys after MPTP administration. In this work the motor activity of monkeys before and after MPTP administration is measured and compared with the activity of a control intact group by means of a telemetry system. A pronounced decrease in motor activity was observed after MPTP administration. These results suggest the monitoring method used is suited for characterizing the motor incapacity and possible improvements following treatments to test different therapies to control Parkinson's disease in MPTP models involving primates.
Barcia
C
C
Experimental Neurology and Neurosurgery, Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, Campus of Espinardo, 30071 Murcia, Spain. barcia@um.es
De Pablos
V
V
Bautista-Hernández
V
V
Sanchez-Bahillo
A
A
Fernández-Barreiro
A
A
Poza
M
M
Herrero
M T
MT
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D008252:Macaca fascicularis; D009043:Motor Activity / Q000502:physiology*; D019957:Motor Skills Disorders / Q000139:chemically induced / Q000503:physiopathology*; D013223:Statistics as Topic; D013686:Telemetry / Q000379:methods*
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine