title: Treatment of gastroesophageal reflux disease.
abstract: Therapeutic modalities for gastroesophageal reflux disease (GERD) continue to evolve despite the introduction of proton pump inhibitors (PPIs), the most successful antireflux class of drugs. On-demand modalities such as antacids and alginates as well as histamine type-2 receptor antagonists continue to be popular with GERD patients who seek temporary relief of symptoms. The PPIs have revolutionized the treatment of patients with severe erosive esophagitis, complications of GERD, and atypical or extraesophageal manifestations of GERD. Antireflux surgery, commonly performed via laparoscopy, remains popular among patients who do not wish to take medications long term. In addition, the recent introduction of various endoscopic techniques offers GERD patients a long-term solution with less morbidity and lower cost than antireflux surgery.
authors.affiliation: Neuro-Enteric Clinical Research Group, Department of Medicine, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson 85723, USA. Ronnie.Fass@med.VA.gov
authors.forename: Ronnie
authors.initials: R
authors.lastname: Fass
authors.forename: Jimmy
authors.initials: J
authors.lastname: Bautista
authors.forename: Sailajah
authors.initials: S
authors.lastname: Janarthanan
mesh_terms: D000863:Antacids / Q000008:administration & dosage; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000601:surgery*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage; D006801:Humans; D008787:Metoclopramide / Q000008:administration & dosage; D054328:Proton Pump Inhibitors
chemical_list: D000863:Antacids; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D008787:Metoclopramide