Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages.
Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.
Jorajuria
Sylvie
S
CEA, Service de Neurovirologie, Université Paris XI, CRSSA, EPHE, IPS, Fontenay-aux-Roses, France.
Dereuddre-Bosquet
Nathalie
N
Naissant-Storck
Karen
K
Dormont
Dominique
D
Clayette
Pascal
P
D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / Q000378:metabolism; D015658:HIV Infections / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); D015850:Interleukin-6; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012333:RNA, Messenger; D012269:Ribosomal Proteins; D014409:Tumor Necrosis Factor-alpha; C073492:ABCC4 protein, human; C120809:ABCC5 protein, human; C421109:multidrug resistance-associated protein 1