Delivery systems for bone growth factors - the new players in skeletal regeneration.
Given the challenge of an increasing elderly population, the ability to repair and regenerate traumatised or lost tissue is a major clinical and socio-economic need. Pivotal in this process will be the ability to deliver appropriate growth factors in the repair cascade in a temporal and tightly regulated sequence using appropriately designed matrices and release technologies within a tissue engineering strategy. This review outlines the current concepts and challenges in growth factor delivery for skeletal regeneration and the potential of novel delivery matrices and biotechnologies to influence the healthcare of an increasing ageing population.
Rose
Felicity R A J
FR
School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. F.Rose@nottingham.ac.uk
Hou
Qingpu
Q
Oreffo
Richard O C
RO
D001847:Bone Diseases / Q000188:drug therapy / Q000628:therapy*; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D001861:Bone Regeneration; D001842:Bone and Bones / Q000502:physiology*; D002352:Carrier Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D016207:Cytokines / Q000008:administration & dosage / Q000627:therapeutic use; D004337:Drug Carriers; D015316:Genetic Therapy; D006801:Humans; D023822:Tissue Engineering; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000627:therapeutic use
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D016207:Cytokines; D004337:Drug Carriers; D016212:Transforming Growth Factor beta; C066845:pleiotrophin