title: First passage time problem for a drifted Ornstein-Uhlenbeck process.
abstract: We consider a continuous stochastic process defined as a drifted Ornstein-Uhlenbeck, for which the first passage time is of interest. The process being non-homogeneous, the first passage time probability density function cannot be found analytically, but numerical methods enable to find its estimate. Estimating the first passage time implies solving an unsteady convection-diffusion equation, with variable coefficients, and we use an implicit Euler scheme to solve it. This work is applied to simulated data, and the continuous process is inspired from recent work on biological marker modelling for HIV-positive patients. The first passage time probability density function can be useful to compare the marker progression in different groups. Numerical results show that the first passage time is highly dependent from the process perturbation, and is then more relevant than methods not considering the stochastic process directly to compare the progression.
authors.affiliation: Laboratoire MAP5, Université Paris 5, 75006 Paris, France. madec@vjf.inserm.fr
authors.forename: Yoann
authors.initials: Y
authors.lastname: Madec
authors.forename: Caroline
authors.initials: C
authors.lastname: Japhet
mesh_terms: D015415:Biomarkers; D003198:Computer Simulation; D018450:Disease Progression; D015658:HIV Infections / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011336:Probability; D013269:Stochastic Processes; D013997:Time Factors
chemical_list: D015415:Biomarkers