Ontogeny of Langerin/CD207 expression in the epidermis of mice.
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules. We studied the emergence of Langerin expression in LC in epidermal sheets and cell suspensions during ontogeny. Langerin appears later than MHC II expression. Intracellular Langerin expression becomes apparent 2-3 d after birth. Only 10 days after birth all LC co-express Langerin. The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules.
Tripp
Christoph H
CH
Department of Dermatology, University of Innsbruck, Innsbruck, Austria.
Chang-Rodriguez
Souyet
S
Stoitzner
Patrizia
P
Holzmann
Sandra
S
Stössel
Hella
H
Douillard
Patrice
P
Saeland
Sem
S
Koch
Franz
F
Elbe-Bürger
Adelheid
A
Romani
Nikolaus
N
D000367:Age Factors; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D004817:Epidermis / Q000737:chemistry*; D005434:Flow Cytometry; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007801:Langerhans Cells / Q000737:chemistry*; D037181:Lectins, C-Type / Q000032:analysis*; D037241:Mannose-Binding Lectins / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C
D000954:Antigens, Surface; C498497:Cd207 protein, mouse; D000949:Histocompatibility Antigens Class II; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins