Cytologic characteristics of pulmonary papillary adenoma. A case report.
BACKGROUND
Pulmonary papillary adenoma is a benign pulmonary neoplasm. Previously pulmonary papillary adenoma was described in terms of immunohistochemistry and ultrastructure. However, there are no previous reports describing the cytologic characteristics of pulmonary papillary adenoma.


METHODS
A 50-year-old male was admitted for evaluation of a coin lesion in the left upper lung field. Radiologic images showed a solid, round tumor approximately 25 mm in diameter in the left upper lung. Transbronchial needle aspiration biopsy (TBNA) was performed, and small numbers of atypical cells were collected. Adenocarcinoma was suggested clinically, and left upper segmentectomy was performed. The histologic diagnosis was pulmonary papillary adenoma. Imprint cytology of the cut surface of the tumor showed tumor cells arranged in sheets that contained scant or vesicular cytoplasm. The nuclei were oval or round, without obvious anisokaryosis, and their chromatin was fine, without hyperchromasia. Cytologically, the nuclei of the tumor cells in the imprint specimen (38.70 +/- 8.69 microns 2) were uniform in size and similar to the atypical cells in the TBNA specimen (38.29 +/- 11.56 microns 2) but significantly larger than the nuclei of the bronchial cells (23.61 +/- 5.98 microns 2) (P < .0001).


CONCLUSIONS
The cytologic appearance of pulmonary papillary adenoma was characterized morphologically and morphometrically. The possibility of cytodiagnosis by TBNA was suggested.
Minami
Yuko
Y
Departments of Surgery and Clinical Pathology, Institute of Clinical Medicine, Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Morishita
Yukio
Y
Yamamoto
Tatsuo
T
Iijima
Tatsuo
T
Fukasawa
Masakatsu
M
Ishikawa
Shigemi
S
Ichimura
Hideo
H
Noguchi
Masayuki
M
D000236:Adenoma / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D001980:Bronchi / Q000378:metabolism / Q000473:pathology*; D002467:Cell Nucleus / Q000235:genetics / Q000473:pathology; D048429:Cell Size / Q000235:genetics; D002869:Chromosome Aberrations; D003593:Cytoplasm / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007620:Karyometry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D037662:Pulmonary Surfactant-Associated Protein A / Q000378:metabolism; D011859:Radiography
D014408:Biomarkers, Tumor; D037662:Pulmonary Surfactant-Associated Protein A