title: Effect of dietary fiber intake on blood pressure: a randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  To examine the effect of dietary fiber intake on blood pressure (BP).
  
  
  METHODS
  Randomized, double-blind, placebo-controlled trial.
  
  
  METHODS
  A total of 110 trial participants aged 30 to 65 years who had untreated, but higher than optimal BP or stage-1 hypertension were recruited from the community in New Orleans, Louisiana, USA.
  
  
  METHODS
  Study participants were randomly assigned to receive 8 g/day of water-soluble fiber from oat bran or a control intervention.
  
  
  METHODS
  Nine BP measurements were obtained by trained observers using random-zero sphygmomanometers, over three clinical visits, at the baseline and termination visits of the trial. An average of the nine measurements was used to determine mean BP at the baseline and termination visits.
  
  
  RESULTS
  The net changes [95% confidence interval, (CI)] in systolic blood pressure were -1.8 mmHg (-4.3 to 0.8, P = 0.17) following 12 weeks, -2.2 mmHg (-5.3 to 1.0, P = 0.18) following 6 weeks, and -2.0 mmHg (-4.4 to 0.3, P = 0.09) for an average of the 6- and 12-week visits. The corresponding net changes (95% CI) in diastolic blood pressure were -1.2 mmHg (-3.0 to 0.5, P = 0.17) following 12 weeks, -0.8 mmHg (-3.1 to 1.4, P = 0.47) following 6 weeks, and -1.0 mmHg (-2.6 to 0.5, P = 0.19) for an average of the 6- and 12-week visits.
  
  
  CONCLUSIONS
  Our findings suggest that a diet rich in fiber may have a moderate BP-lowering effect and indicate the need for further investigation of this important question.
authors.affiliation: Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA. jhe@tulane.edu
authors.forename: Jiang
authors.initials: J
authors.lastname: He
authors.forename: Richard H
authors.initials: RH
authors.lastname: Streiffer
authors.forename: Paul
authors.initials: P
authors.lastname: Muntner
authors.forename: Marie A
authors.initials: MA
authors.lastname: Krousel-Wood
authors.forename: Paul K
authors.initials: PK
authors.lastname: Whelton
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008145:Louisiana / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D012016:Reference Values; D013599:Systole / Q000187:drug effects; D013997:Time Factors