title: Feasibility of breast-conserving therapy for macroscopically multiple ipsilateral breast cancer.
abstract: OBJECTIVE
  Macroscopically multiple ipsilateral breast cancer (MMIBC) is generally considered a contraindication for breast-conserving therapy (BCT). The result of BCT for MMIBC is reported and the feasibility discussed.
  
  
  METHODS
  Between July 1993 and February 1999, 34 patients with MMIBC underwent BCT at our clinic. The local control, disease-free survival, and cosmetic results in these patients were compared with those of patients with single disease.
  
  
  RESULTS
  After wide excision, 21 (62%) of 34 patients with MMIBC had a close surgical margin and the rate was significantly greater than that of patients with a single lesion. However, the size of the boost irradiation field was not significantly increased. At a median follow-up of 98 months, no statistically significant difference was noted in local control, disease-free survival, or cosmetic result compared with patients with a single lesion.
  
  
  CONCLUSIONS
  Although patients with MMIBC frequently had close surgical margins after BCT, it can be a treatment option for these patients as long as the close surgical margin is accurately detected and treated with an appropriate radiation technique.
authors.affiliation: Department of Therapeutic Radiology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Setsuko
authors.initials: S
authors.lastname: Okumura
authors.forename: Michihide
authors.initials: M
authors.lastname: Mitsumori
authors.forename: Chikako
authors.initials: C
authors.lastname: Yamauchi
authors.forename: Sachiko
authors.initials: S
authors.lastname: Kawamura
authors.forename: Natsuo
authors.initials: N
authors.lastname: Oya
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nagata
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Masaki
authors.initials: M
authors.lastname: Kokubo
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mise
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kodama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000532:radiotherapy / Q000601:surgery*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies