Correlations in the cytokine system in endometrial hyperplasia.
Correlations between local expression of insulin-like growth factor 1, insulin-like growth factor receptor, epithelial growth factor, transforming growth beta2 factor, PCNA, TNF-alpha, TNF receptor 1, Fas, FasL, IFN-gamma, IL-1beta, IL-4, IL-6, IL-8, IL-10, and IL-12 genes in intact and hyperplastic endometrium and in the endometrium after hormone therapy were analyzed. Numerous correlations at the proliferation and secretion stages of the menstrual cycle indicate balanced cytokine system. The number of correlations decreases in glandular cystic and more so in atypical hyperplasia, indicating imbalance in the cytokine system. Dufastone and zoladex therapy did not lead to recovery of this balance, but higher correlations between the expression of some factors of cell proliferation attest to the beginning of normalization of pathologically changed endometrium.
Zhdanov
A V
AV
Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, Moscow.
Sukhikh
G T
GT
Davydova
M P
MP
Slukina
T V
TV
Chernukha
G E
GE
Samoilova
T E
TE
Smetnik
V P
VP
D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology; D017209:Apoptosis; D002455:Cell Division; D016207:Cytokines / Q000096:biosynthesis* / Q000378:metabolism; D003851:Deoxyribonucleases / Q000378:metabolism; D004714:Endometrial Hyperplasia / Q000473:pathology*; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D004815:Epidermal Growth Factor / Q000378:metabolism; D005260:Female; D017273:Goserelin / Q000494:pharmacology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008597:Menstrual Cycle; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018931:Antineoplastic Agents, Hormonal; D016207:Cytokines; D018809:Proliferating Cell Nuclear Antigen; D012333:RNA, Messenger; D017273:Goserelin; D004815:Epidermal Growth Factor; D012313:RNA; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1; D003851:Deoxyribonucleases