Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis.
Three new acetylated flavonoid glycosides, 5,6,4'-trihydroxyflavone 7-O-alpha-L-2,3-di-O-acetylrhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (1), apigenin 7-O-alpha-L-3-O-acetylrhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (2), and apigenin 7-O-alpha-L-2,3-di-O-acetylrhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (3), were isolated from Scoparia dulcis together with the known compound eugenyl beta-D-glucopyranoside (4). Their structures were elucidated by spectroscopic analyses. Compounds 2 and 3 showed an enhancing activity of nerve growth factor-mediated neurite outgrowth in PC12D cells.
Li
Yushan
Y
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Chen
Xigui
X
Satake
Masayuki
M
Oshima
Yasukatsu
Y
Ohizumi
Yasushi
Y
D000107:Acetylation; D000818:Animals; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000502:physiology*; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D036721:Scoparia / Q000737:chemistry*; D013237:Stereoisomerism
D005419:Flavonoids; D006027:Glycosides; D020932:Nerve Growth Factor