Recurrent biological neural networks: the weak and noisy limit.
A perturbative method is developed for calculating the effects of recurrent synaptic interactions between neurons embedded in a network. A series expansion is constructed that converges for networks with noisy membrane potential and weak synaptic connectivity. The terms of the series can be interpreted as loops of interactions between neurons, so the technique is called a loop expansion. A diagrammatic method is introduced that allows for construction of analytic expressions for the parameter dependencies of the spike-probability function and correlation functions. An analytic expression is obtained to predict the effect of the surrounding network on a neuron during an intracellular current injection. The analytic results are compared with simulations to test the range of their validity and significant effects of the the recurrent connections in network are accurately predicted by the loop expansion.
Roberts
Patrick D
PD
Neurological Sciences Institute, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, Oregon 97006, USA. robertpa@ohsu.edu
D000200:Action Potentials / Q000502:physiology*; D005246:Feedback / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D015233:Models, Statistical; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013269:Stochastic Processes; D009435:Synaptic Transmission / Q000502:physiology*