title: Enantioselective iodolactonization catalyzed by chiral quaternary ammonium salts derived from cinchonidine.
abstract: Chiral quaternary ammonium salts derived from cinchonidine have been applied to catalyze the stereoselective iodolactonizations of trans-5-aryl-4-pentenoic acids leading to a mixture of two regioselectively iodolactonized products with fair to excellent yield (37-98%) and moderate enantioselectivity (exo = 42.0% ee, endo = 31.0% ee) under mild conditions. This work is the first example of asymmetric iodolactonization reaction in the presence of less than a stoichiometric amount of chiral reagent.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, 130022, P. R. China.
authors.forename: Mang
authors.initials: M
authors.lastname: Wang
authors.forename: Lian Xun
authors.initials: LX
authors.lastname: Gao
authors.forename: Wen Peng
authors.initials: WP
authors.lastname: Mai
authors.forename: Ai Xiang
authors.initials: AX
authors.lastname: Xia
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Suo Bo
authors.initials: SB
authors.lastname: Zhang