Detection of serum Chlamydia pneumoniae (Cpn) immune complex and Cpn antibody in patients with coronary heart disease.
OBJECTIVE
To understand the state of Chlamydia pneumoniae (Cpn) infection in patients with coronary heart disease (CHD), and explore the relationship between Cpn infection and the gonesis and progressin of CHD.


METHODS
By adopting sandwich method with double antibodies and indirect ELISA method, we detected serum Cpn immune complex and IgG antibody in 160 CHD patients (confirmed by coronary artery angiography) and 40 subjects without CHD.


RESULTS
The positivity rate of Cpn IgG type immune complex in the CHD group (63.8%) was significantly higher than that in the control group (40.0%, P<0.05), similar to the results of Cpn IgG antibody detection (65.0% vs 32.5%, P<0.05).


CONCLUSIONS
Cpn infection is closely connected with the CHD, but their exact relationship needs further exploration and study.
Sun
Yun-yun
YY
Institute of Cardiovascular Disease of Guangdong Province, Guangzhou 510100, China. sunyunyun54321@sina.com
Jiang
Wen-ling
WL
Luo
Xian-ling
XL
Chen
Ji-yan
JY
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D000936:Antigen-Antibody Complex / Q000097:blood*; D000942:Antigens, Bacterial / Q000097:blood*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D003327:Coronary Disease / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D007074:Immunoglobulin G