Effect of ticlopidine on monocyte-derived microparticles and activated platelet markers in diabetes mellitus.
Platelet-derived microparticles, activated platelets, and monocyte-derived microparticles were measured in 73 patients with diabetes mellitus. A comparative study of these parameters was performed before and after administration of ticlopidine. The number of platelet-derived microparticles and activated platelets was increased significantly in diabetic patients. Monocyte-derived microparticles were also increased significantly. After administration of ticlopidine, platelet-derived microparticles and activated platelets corrected positively, not only CD62P- and CD63-positive platelets, but also platelet-derived microparticles and monocyte-derived microparticles showed a significant decrease. These data suggest that in patients with diabetes, platelet-derived microparticles and activated platelets stimulate the activation of monocytes and promote the production of monocyte-derived microparticles, and that ticlopidine is useful for hypercoagulabillity in diabetic patients.
Shouzu
Akira
A
Osaka Saiseikai Izuo Hospital based on Social Welfare Organization Saiseikai Imperial Gift Foundation Inc., Kitamura, Osaka, Japan. tounyou@izuo-saiseikai.gr.jp
Nomura
Shosaku
S
Omoto
Seitaro
S
Hayakawa
Takashi
T
Nishikawa
Mitsushige
M
Iwasaka
Toshiji
T
D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D019007:P-Selectin / Q000378:metabolism; D015539:Platelet Activation / Q000187:drug effects*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D060149:Tetraspanin 30; D013988:Ticlopidine / Q000008:administration & dosage / Q000494:pharmacology*
D015703:Antigens, CD; D015415:Biomarkers; C554586:CD63 protein, human; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D060149:Tetraspanin 30; D013988:Ticlopidine