title: Three validation metrics for automated probabilistic image segmentation of brain tumours.
abstract: The validity of brain tumour segmentation is an important issue in image processing because it has a direct impact on surgical planning. We examined the segmentation accuracy based on three two-sample validation metrics against the estimated composite latent gold standard, which was derived from several experts' manual segmentations by an EM algorithm. The distribution functions of the tumour and control pixel data were parametrically assumed to be a mixture of two beta distributions with different shape parameters. We estimated the corresponding receiver operating characteristic curve, Dice similarity coefficient, and mutual information, over all possible decision thresholds. Based on each validation metric, an optimal threshold was then computed via maximization. We illustrated these methods on MR imaging data from nine brain tumour cases of three different tumour types, each consisting of a large number of pixels. The automated segmentation yielded satisfactory accuracy with varied optimal thresholds. The performances of these validation metrics were also investigated via Monte Carlo simulation. Extensions of incorporating spatial correlation structures using a Markov random field model were considered.
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, U.S.A. zou@bwh.harvard.edu
authors.forename: Kelly H
authors.initials: KH
authors.lastname: Zou
authors.forename: William M
authors.initials: WM
authors.lastname: Wells
authors.forename: Ron
authors.initials: R
authors.lastname: Kikinis
authors.forename: Simon K
authors.initials: SK
authors.lastname: Warfield
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008390:Markov Chains; D015233:Models, Statistical; D009010:Monte Carlo Method; D012372:ROC Curve; D012680:Sensitivity and Specificity