Gap junctions and connexin-interacting proteins.
Gap junctions form channels between adjacent cells. The core proteins of these channels are the connexins. Regulation of gap junction communication (GJC) can be modulated by connexin-associating proteins, such as regulatory protein phosphatases and protein kinases, of which c-Src is the best-studied. Structural proteins, notably zona occludens-1 (ZO-1) and microtubules, have been found recently at gap junctions. Along with the expansion of the list of connexin-associating proteins, reports have appeared that suggest that connexins might have additional roles in addition to their channel function, such as transcriptional and cytoskeletal regulation. Here, gap junction interacting proteins are reviewed and their function is addressed. The striking similarity of proteins present at the cytoplasmic face of tight junctions, adherens junctions and gap junctions and their possible role in gene transcription and cytoskeletal anchorage is highlighted.
Giepmans
Ben N G
BN
Department of Neurosciences, The National Center of Microscopy and Imaging Research, University of California San Diego, School of Medicine, 1000 BSB, 9500 Gilman Drive, MC0608, La Jolla, CA 92093-0608, USA. giepmans@ncmir.ucsd.edu
D022005:Adherens Junctions / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion; D002450:Cell Communication; D017630:Connexins / Q000378:metabolism*; D016384:Consensus Sequence; D017629:Gap Junctions / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008870:Microtubules / Q000378:metabolism; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000378:metabolism; D019108:Tight Junctions / Q000378:metabolism; D062826:Zonula Occludens-1 Protein
D017630:Connexins; D008565:Membrane Proteins; D010750:Phosphoproteins; C569042:TJP1 protein, human; C569043:Tjp1 protein, mouse; D062826:Zonula Occludens-1 Protein