Dobutamine-induced eosinophilia.
A man with dilated cardiomyopathy presented with decompensated heart failure and marked eosinophilia. After extensive clinical and laboratory evaluation for hypereosinophilic syndrome, including a myocardial biopsy, it was determined by means of rechallenge (second dobutamine infusion) that the patient was afflicted with dobutamine-induced eosinophilia. This report is important because of the high utilization rate of this drug in a sick population. Simply discontinuing it or switching to another agent can avert the high cost and risk of the evaluation for hypereosinophilic syndrome in this compromised group of patients.
El-Sayed
Osama M
OM
Division of Cardiology, The Ohio State University Medical Center, Columbus, Ohio, USA.
Abdelfattah
Rehab R
RR
Barcelona
Robert
R
Leier
Carl V
CV
D002311:Cardiomyopathy, Dilated / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000009:adverse effects*; D004280:Dobutamine / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
D002316:Cardiotonic Agents; D004280:Dobutamine