Perturbation of epigenetic status by toxicants.
It is becoming increasingly apparent that toxicant-induced changes in epigenetic status, particularly DNA methylation patterns, may play a role in some mechanisms of toxicity. Here, we discuss briefly the evidence that alterations in DNA methylation accompany, and may even promote, carcinogenesis induced by non-genotoxic chemicals. We also address recent findings indicating that the availability of dietary methyl donors can modulate DNA methylation levels and precipitate adverse effects.
Bombail
Vincent
V
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.
Moggs
Jonathan G
JG
Orphanides
George
G
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D019175:DNA Methylation / Q000187:drug effects; D004032:Diet; D004968:Estrogens, Non-Steroidal / Q000633:toxicity; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D014118:Toxins, Biological / Q000633:toxicity*
D002273:Carcinogens; D004968:Estrogens, Non-Steroidal; D014118:Toxins, Biological