title: Structure of OsmC from Escherichia coli: a salt-shock-induced protein.
abstract: The crystal structure of an osmotically inducible protein (OsmC) from Escherichia coli has been determined at 2.4 A resolution. OsmC is a representative protein of the OsmC sequence family, which is composed of three sequence subfamilies. The structure of OsmC provides a view of a salt-shock-induced protein. Two identical monomers form a cylindrically shaped dimer in which six helices are located on the inside and two six-stranded beta-sheets wrap around these helices. Structural comparison suggests that the OsmC sequence family has a peroxiredoxin function and has a unique structure compared with other peroxiredoxin families. A detailed analysis of structures and sequence comparisons in the OsmC sequence family revealed that each subfamily has unique motifs. In addition, the molecular function of the OsmC sequence family is discussed based on structural comparisons among the subfamily members.
authors.affiliation: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.
authors.forename: Dong Hae
authors.initials: DH
authors.lastname: Shin
authors.forename: In-Geol
authors.initials: IG
authors.lastname: Choi
authors.forename: Didier
authors.initials: D
authors.lastname: Busso
authors.forename: Jaru
authors.initials: J
authors.lastname: Jancarik
authors.forename: Hisao
authors.initials: H
authors.lastname: Yokota
authors.forename: Rosalind
authors.initials: R
authors.lastname: Kim
authors.forename: Sung-Hou
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D018360:Crystallography, X-Ray; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010544:Peroxidases / Q000737:chemistry / Q000378:metabolism; D054464:Peroxiredoxins; D011487:Protein Conformation; D012492:Salts; D017386:Sequence Homology, Amino Acid; D040681:Structural Homology, Protein
chemical_list: D029968:Escherichia coli Proteins; D012492:Salts; C099394:osmC protein, E coli; D010544:Peroxidases; D054464:Peroxiredoxins