title: Are the cardiac effects of anabolic steroid abuse in strength athletes reversible?
abstract: OBJECTIVE
  To investigate the reversibility of adverse cardiovascular effects after chronic abuse of anabolic androgenic steroids (AAS) in athletes.
  
  
  METHODS
  Doppler echocardiography and cycle ergometry including measurements of blood pressure at rest and during exercise were undertaken in 32 bodybuilders or powerlifters, including 15 athletes who had not been taking AAS for at least 12 months (ex-users) and 17 currently abusing AAS (users), as well as in 15 anabolic-free weightlifters.
  
  
  RESULTS
  Systolic blood pressure was higher in users (mean (SD) 140 (10) mm Hg) than in ex-users (130 (5) mm Hg) (p < 0.05) or weightlifters (125 (10) mm Hg; p < 0.001). Left ventricular muscle mass related to fat-free body mass and the ratio of mean left ventricular wall thickness to internal diameter were not significantly higher in users (3.32 (0.48) g/kg and 42.1 (4.4)%) than in ex-users (3.16 (0.53) g/kg and 40.3 (3.8)%), but were lower in weightlifters (2.43 (0.26) g/kg and 36.5 (4.0)%; p < 0.001). Left ventricular wall thickness related to fat-free body mass was also lower in weightlifters, but did not differ between users and ex-users. Left ventricular wall thickness was correlated with a point score estimating AAS abuse in users (r = 0.49, p < 0.05). In all groups, systolic left ventricular function was within the normal range. The maximum late transmitral Doppler flow velocity (Amax) was higher in users (61 (12) cm/s) and ex-users (60 (12) cm/s) than in weightlifters (50 (9) cm/s; p < 0.05 and p = 0.054).
  
  
  CONCLUSIONS
  Several years after discontinuation of anabolic steroid abuse, strength athletes still show a slight concentric left ventricular hypertrophy in comparison with AAS-free strength athletes.
authors.affiliation: Institute of Sports and Preventive Medicine, University of Saarland Saarbruecken, Germany. a.urhausen@rz.uni-sb.de
authors.forename: A
authors.initials: A
authors.lastname: Urhausen
authors.forename: T
authors.initials: T
authors.lastname: Albers
authors.forename: W
authors.initials: W
authors.lastname: Kindermann
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D004300:Doping in Sports; D004452:Echocardiography; D004562:Electrocardiography; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D008297:Male; D013256:Steroids / Q000009:adverse effects*; D014891:Weight Lifting
chemical_list: D045930:Anabolic Agents; D013256:Steroids