title: The use of sodium enoxaparin in the treatment of tinnitus.
abstract: Tinnitus is a pathological event caused by abnormal stimulation of any point along the acoustic pathway. Generally, it produces a sharp tone accompanied by hearing impairment. Currently, no widely used standard protocol for treatment of this condition exists, and vascular microthrombotic factors are considered as the main determinants. Prompted by such observations, we implemented a protocol using an anticoagulant, sodium enoxaparin. It is a kind of heparin with a low molecular weight and is endowed with antithrombotic activity. We studied 40 patients (ages 20-65 years) who had been experiencing tinnitus for at least 2 months. We divided patients into two groups: To the first group, enoxaparin was administered for 10 days; the patients in the second group were treated with traditional therapy (corticosteroids, vasoactive agents, multivitamins, and anticoagulants). At the beginning and at the end of the therapy period, the patients were evaluated by instrumental examinations. All patients treated with anticoagulant therapy have shown an evident abatement of their tinnitus symptom. No patient experienced side effects from this treatment. The results indicate that administration of sodium enoxaparin is an excellent mode of therapy for patients with tinnitus.
authors.affiliation: Ear, Nose, and Throat Department, University of Genoa, Genoa, Italy. renzomora@libero.it
authors.forename: Renzo
authors.initials: R
authors.lastname: Mora
authors.forename: Angelo
authors.initials: A
authors.lastname: Salami
authors.forename: Marco
authors.initials: M
authors.lastname: Barbieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Mora
authors.forename: Giulio Cesare
authors.initials: GC
authors.lastname: Passali
authors.forename: Saverio
authors.initials: S
authors.lastname: Capobianco
authors.forename: Jacques
authors.initials: J
authors.lastname: Magnan
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D017984:Enoxaparin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012044:Regression Analysis; D014012:Tinnitus / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin