Drug metabolism and ageing.
Important changes in drug metabolism occur with ageing. Age-associated reductions in function of some but not all cytochrome P450 enzymes (CYPs) have been described. Induction and inhibition of CYPs needs to be revisited in light of recent advances. The function and pharmacology of transporters have not yet been examined for an age-related effect. Finally, the concept of frailty is being underpinned by studies documenting a decline in drug metabolism and changes in disposition in frail older people compared with either healthy elderly or the young.
Kinirons
M T
MT
Department of Health Care of the Elderly, Guy's, King's, and St Thomas' School of Medicine, King's College London, London, UK. mark.kinirons@gstt.sthames.nhs.uk
O'Mahony
M S
MS
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000368:Aged; D000375:Aging / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D004032:Diet; D004950:Esterases / Q000378:metabolism; D016330:Frail Elderly; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D004950:Esterases