title: Systemic thrombolytic therapy for late-onset portal vein thrombosis after living-donor liver transplantation.
abstract: BACKGROUND
  There have been few reports of noninvasive treatment for portal vein thrombosis (PVT) after liver transplantation.
  
  
  METHODS
  One adult patient and four pediatric patients developed PVT 5, 14, 14, 16, and 43 months after living-donor liver transplantation, respectively. All five of the patients received a 10-day course of systemic thrombolytic therapy with recombinant tissue plasminogen activator.
  
  
  RESULTS
  After the treatment was completed, successful portal vein recanalization was demonstrated on ultrasonography or multidetector three-dimensional computed tomography angiography in all five cases.
  
  
  CONCLUSIONS
  Noninvasive treatment with systemic recombinant tissue plasminogen activator should be considered for selected patients with late-onset PVT after liver transplantation.
authors.affiliation: Department of Surgery, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan.
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Chao-Long
authors.initials: CL
authors.lastname: Chen
authors.forename: Yaw-Sen
authors.initials: YS
authors.lastname: Chen
authors.forename: Yu-Fan
authors.initials: YF
authors.lastname: Cheng
authors.forename: Tung-Liang
authors.initials: TL
authors.lastname: Huang
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D011169:Portal Vein; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator