Transplantation of neural stem cells into explants of rat inner ear.
Damage and loss of hair cells in the inner ear is the most frequent cause of hearing loss and balance disorders. Mammalian hair cells do not regenerate in the conventional ways. To regenerate the hair cell in the mammalian inner ear we transplanted neural stem cells into explants of rat inner ear. The stem cells integrated successfully into the sensory epithelium of the vestibular organs, but not into the organ of Corti. This method is useful to investigate efficient ways to transplant stem cells into the inner ear.
Fujino
Kiyohiro
K
Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. fujino@ent.kuhp.kyoto-u.ac.jp
Kim
Tae-Soo
TS
Nishida
Akiko T
AT
Nakagawa
Takayuki
T
Omori
Koichi
K
Naito
Yasushi
Y
Ito
Juichi
J
D000818:Animals; D016022:Case-Control Studies; D007758:Ear, Inner / Q000166:cytology* / Q000502:physiology; D006198:Hair Cells, Auditory / Q000502:physiology*; D006311:Hearing Disorders / Q000628:therapy*; D023421:Models, Animal; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods