title: Gene-gene interactions between glutathione-s transferase M1 and matrix metalloproteinase 9 in the formation of hereditary predisposition to chronic obstructive pulmonary disease.
abstract: The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.7).
authors.affiliation: Department of Molecular Genetic Technologies, Research Center, St. Petersburg I. P. Pavlov State Medical University, St. Petersburg. dr-lena@mail.ru
authors.forename: E D
authors.initials: ED
authors.lastname: Yanchina
authors.forename: T V
authors.initials: TV
authors.lastname: Ivchik
authors.forename: E I
authors.initials: EI
authors.lastname: Shvarts
authors.forename: A N
authors.initials: AN
authors.lastname: Kokosov
authors.forename: N E
authors.initials: NE
authors.lastname: Khodzhayantz
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase; D020780:Matrix Metalloproteinase 9