title: Tamponade efficiency of perfluorohexyloctane and silicone oil solutions in a model eye chamber.
abstract: OBJECTIVE
  As no single tamponade agent yet fulfils all the requirements of a long term inferior tamponade, attempts have been made to mix tamponade materials. This study investigated perfluorohexyloctane (F(6)H(8)) and silicone oil solutions designed to take advantage of the high specific gravity and interfacial tension of the F(6)H(8) and the high viscosity of silicone oil.
  
  
  METHODS
  Solutions of three different densities were examined (1.01, 1.03 and 1.06 g/cm(3)) inside transparent chambers made of surface modified poly(methylmethacrylate) (PMMA).
  
  
  RESULTS
  Compared to F(6)H(8), the solutions had poorer contact with hydrophilic surface of the chambers. The higher the specific gravity of the solution, the better was the contact. The solution with a specific gravity 1.01 g/cm(3) is probably of no use clinically.
  
  
  CONCLUSIONS
  The model eye chamber made of surface modified PMMA is an efficient way of screening and choosing solutions with promising physical properties. Solutions of silicone oil with F(6)H(8) in other proportions or with other semifluorinated alkanes may be of interest.
authors.affiliation: Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK.
authors.forename: C
authors.initials: C
authors.lastname: Wetterqvist
authors.forename: D
authors.initials: D
authors.lastname: Wong
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: T
authors.initials: T
authors.lastname: Stappler
authors.forename: E
authors.initials: E
authors.lastname: Herbert
authors.forename: S
authors.initials: S
authors.lastname: Freeburn
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005123:Eye / Q000033:anatomy & histology*; D005466:Fluorocarbons / Q000737:chemistry*; D006801:Humans; D008953:Models, Anatomic; D019904:Polymethyl Methacrylate; D011312:Pressure; D012163:Retinal Detachment / Q000628:therapy; D012827:Silicone Oils / Q000737:chemistry*; D013046:Specific Gravity; D013499:Surface Properties; D014783:Viscosity
chemical_list: D005466:Fluorocarbons; D012827:Silicone Oils; C118616:perfluorohexyl-octan; D019904:Polymethyl Methacrylate