title: Conformational changes associated with protein-protein interactions.
abstract: Motions related to protein-protein binding events can be surveyed from the perspective of the Database of Macromolecular Movements. There are a number of alternative conceptual models that describe these events, particularly induced fit and pre-existing equilibrium. There is evidence for both alternatives from recent studies of conformational change. However, there is increasing support for the pre-existing equilibrium model, whereby proteins are found to simultaneously exist in populations of diverse conformations.
authors.affiliation: Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.
authors.forename: Chern-Sing
authors.initials: CS
authors.lastname: Goh
authors.forename: Duncan
authors.initials: D
authors.lastname: Milburn
authors.forename: Mark
authors.initials: M
authors.lastname: Gerstein
mesh_terms: D000494:Allosteric Regulation / Q000502:physiology; D008958:Models, Molecular; D011485:Protein Binding / Q000502:physiology; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins