Comparison of EUS-guided 19-gauge Trucut needle biopsy with EUS-guided fine-needle aspiration.
OBJECTIVE
The accuracy of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) depends on immediate specimen review by a cytopathologist. Stromal tumors, lymphoma, and well-differentiated pancreatic cancer are difficult to diagnose on the basis of cytology alone. To overcome these limitations, a 19-gauge Trucut needle has been developed to obtain histological samples at EUS. This pilot study compares the specimen adequacy and diagnostic accuracy of EUS-guided Trucut needle biopsy (EUS-TNB) with EUS-FNA.


METHODS
A total of 18 patients underwent EUS-TNB and EUS-FNA. The specimen adequacy and diagnostic accuracy of the two techniques was compared. The technical performance and safety profile of the Trucut needle were also evaluated.


RESULTS
The EUS-TNB specimen was adequate for evaluation in 15/18 patients compared with 18/18 with EUS-FNA (83 % vs. 100 %, not significant). The diagnostic accuracy of EUS-TNB was not significantly different from EUS-FNA (78 % vs. 89 %). Two complications were encountered: one patient developed mediastinitis and required surgery; another had immediate bleeding that was managed conservatively. One technical problem was encountered: the Trucut needle failed to deploy after two passes when a gastric stromal cell tumor was being biopsied.


CONCLUSIONS
The diagnostic accuracy of the new EUS-TNB is comparable to that of EUS-FNA. In our experience, the overall efficacy and safety profile of the Trucut needle appears modest.
Varadarajulu
S
S
Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, USA. svaradarajulu@yahoo.com
Fraig
M
M
Schmulewitz
N
N
Roberts
S
S
Wildi
S
S
Hawes
R H
RH
Hoffman
B J
BJ
Wallace
M B
MB
D000311:Adrenal Glands / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000295:instrumentation*; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008482:Mediastinum / Q000473:pathology*; D008875:Middle Aged; D009339:Needles; D010179:Pancreas / Q000473:pathology*; D010865:Pilot Projects; D015203:Reproducibility of Results; D013270:Stomach / Q000473:pathology*