title: A case of gastrinoma in a Shih-Tzu dog.
abstract: A five-year-old male Shih-Tzu dog presented with severe vomiting and weight loss. The clinical signs were successfully improved by an eight-day treatment with an H(2)-receptor antagonist, gastrointestinal protectant and antibiotics. Ten days later, however, recurrence of vomiting was seen despite continuous medical treatment. Based on clinical signs and the results of various diagnostic tests including CBC, biochemical analysis, contrast radiography, and endoscopy, a duodenal or pancreatic neoplasm was suspected and exploratory laparotomy was conducted. Some swollen pancreatic regions were found, and biopsy of the pancreas indicated the diagnosis of a gastrin-secreting tumor. Consequently, based on a high serum gastrin level as well as clinical signs and immunohistological findings, we diagnosed the disease as canine gastrinoma, a rare tumor of the pancreas.
authors.affiliation: Veterinary Teaching Hospital, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan.
authors.forename: Ushio
authors.initials: U
authors.lastname: Fukushima
authors.forename: Miyuki
authors.initials: M
authors.lastname: Sato
authors.forename: Shozo
authors.initials: S
authors.lastname: Okano
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Aramaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Oyamada
authors.forename: Masami
authors.initials: M
authors.lastname: Uechi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D004285:Dogs; D015408:Gastrinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D005755:Gastrins / Q000097:blood; D007150:Immunohistochemistry; D007813:Laparotomy; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D011859:Radiography
chemical_list: D005755:Gastrins