Necrolytic acral erythema: response to combination therapy with interferon and ribavirin.
Necrolytic acral erythema is a papulosquamous and sometimes vesiculobullous eruption bearing clinical and histologic similarity to other necrolytic erythemas such as necrolytic migratory erythema, pseudoglucagonoma, and nutritional deficiency syndromes. Necrolytic acral erythema is distinguished by its association with hepatitis C infection and its predominantly acral distribution. We describe a pediatric patient with necrolytic acral erythema whose eruption resolved with hyperalimentation and combination interferon and ribavirin therapy, despite the persistence of detectable viral load and continued hepatic and renal insufficiency.
Hivnor
Chad M
CM
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Yan
Albert C
AC
Junkins-Hopkins
Jacqueline M
JM
Honig
Paul J
PJ
D000169:Acrodermatitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D009336:Necrosis; D010288:Parenteral Nutrition; D011994:Recombinant Proteins; D012254:Ribavirin / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin