Two Salmonella OmpC K(b)-restricted epitopes for CD8+-T-cell recognition.
We report the identification of two peptides from Salmonella OmpC porin that can bind to major histocompatibility complex class I K(b) molecules and are targets of cytotoxic T lymphocytes from Salmonella-infected mice. These peptides are conserved in gram-negative bacterial porins and are the first Salmonella porin-specific epitopes described for possible CD8(+)-T-cell elimination of infected cells.
Diaz-Quiñonez
Alberto
A
Departamento de Biomedicina Molecular, Centro de Investigación y Estudios Avanzados (CINVESTAV), 07000 Mexico City, Mexico.
Martin-Orozco
Natalia
N
Isibasi
Armando
A
Ortiz-Navarrete
Vianney
V
D000818:Animals; D000942:Antigens, Bacterial / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D000939:Epitopes / Q000378:metabolism; D006183:H-2 Antigens / Q000378:metabolism; D007114:Immunization; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D018272:Porins / Q000276:immunology*; D011485:Protein Binding; D012486:Salmonella typhimurium / Q000276:immunology* / Q000472:pathogenicity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000942:Antigens, Bacterial; D000939:Epitopes; D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; C113724:OmpC protein; D018272:Porins