title: Use of sirolimus-eluting coronary stents in routine clinical practice.
abstract: Restenosis has long remained the major limitation of intracoronary stenting, but several randomized trials have recently shown that the use of drug-eluting stents appear to reduce markedly the risk of recurrence following treatment of de novo lesions. To evaluate whether the results of randomized trials can be generalized to routine clinical practice, all patients receiving at least one sirolimus-eluting stent (SES) in two Swiss hospitals were entered into a prospective registry. Only target vessels with a reference diameter > 3.5 mm were excluded. Clinical follow-up was obtained after 6 months. A total of 183 patients were included. The procedural success was 97.8% and the incidence of in-hospital MACE was 2.2%. At 7 +/- 2 months, 95.6% of the patients were event-free, and target lesion revascularization was required in only three patients (1.6%). The excellent medium-term results obtained with the SES in randomized trials can be replicated in routine clinical practice.
authors.affiliation: Department of Cardiology, Clinique Cecil, Lausanne, Switzerland. jjgoy@goyman.com
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Goy
authors.forename: Philip
authors.initials: P
authors.lastname: Urban
authors.forename: Charles
authors.initials: C
authors.lastname: Seydoux
authors.forename: Edoardo
authors.initials: E
authors.lastname: De Benedetti
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Stauffer
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D019917:Blood Vessel Prosthesis Implantation; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000209:etiology; D010818:Practice Patterns, Physicians'; D011446:Prospective Studies; D012086:Reoperation; D020123:Sirolimus / Q000627:therapeutic use*; D015607:Stents; D013557:Switzerland; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D007166:Immunosuppressive Agents; D020123:Sirolimus