All of the components required for angiotensin II formation are expressed locally in human atherosclerotic lesions, including a long suspected player cathepsin G.
Whitman
Stewart C
SC
D000804:Angiotensin II / Q000378:metabolism*; D000808:Angiotensinogen / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000378:metabolism* / Q000601:surgery; D017536:Carotid Artery, Common / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D002402:Cathepsin D / Q000378:metabolism; D056649:Cathepsin G; D002403:Cathepsins / Q000378:metabolism*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D044140:Receptor, Angiotensin, Type 1 / Q000378:metabolism; D012697:Serine Endopeptidases
D012333:RNA, Messenger; D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; D000804:Angiotensin II; D002403:Cathepsins; D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D002402:Cathepsin D