Approaches to transplantation tolerance in humans.
Although transplantation tolerance to organ allografts has been achieved using a wide variety of immunologic interventions in laboratory animals, few tolerance induction protocols with complete immunosuppressive drug withdrawal have been tested in humans. Preclinical and clinical studies of the use of total lymphoid irradiation for the induction of chimeric and nonchimeric tolerance are summarized here.
Strober
Samuel
S
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5166, USA. sstrober@stanford.edu
Lowsky
Robert J
RJ
Shizuru
Judith A
JA
Scandling
John D
JD
Millan
Maria T
MT
D000818:Animals; D006650:Histocompatibility Testing; D006801:Humans; D018183:Transplantation Chimera; D023001:Transplantation Tolerance / Q000276:immunology