The role of free radicals and plasmatic antioxidant in Ménière's syndrome.
The objective of this study was verification, through suitable hematochemical tests, of the supposition that central-systemic microtoxicosis plays a role either in the etiopathogenesis of Ménière's syndrome or in labyrinthine pathological processes or hypoacusis. We did not, therefore, exclude other well-known hypotheses in the causality of these pathologies. Nonetheless, one finds, particularly in the Ménière's cases, a constant homogeneous distribution of the metabolic products of this microtoxicosis, such as a high concentration of free radicals and low natural defenses (e.g., antioxidant plasmatic capacity). Therefore, there exists a kind of dangerous central and systemic presence of reactive molecules, aimed toward the polyunsaturated fatty acids and homeostatic complex enzymes, that is not compensated for by the natural antioxidant defense. The presence of this lack of balance, verified by suitable tests, has shown the rationality of use of a product made from reduced glutathione, thioctic acid, cysteine, and other antioxidants as a multipurpose antidote to this element of etiopathogenesis. Patients were divided into three groups (control, conventional therapy, and antioxidant treatment), and those in the antioxidant treatment group, especially those with Ménière's syndrome, demonstrated a net and more significant improvement. Also, parallel clinical and instrument evaluations of this new therapeutic solution, the efficacy of which has already been positively demonstrated, are expected to provide further evidence to support the primary hypothesis.
Raponi
Giorgio
G
Vertigo Center, S. Rita Hospital, Milan, Italy. xrapon@tin.it
Alpini
Dario
D
Volontè
Stefania
S
Capobianco
Saverio
S
Cesarani
Antonio
A
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D016896:Treatment Outcome
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species