Effects of T-activin and vitamin E on toxicity and antitumor activity of cyclophosphamide.
We studied the effect of combination treatment with T-activin and vitamin E on acute toxicity and antitumor activity of cyclophosphamide in mice. Combined administration of these preparations 1.37-fold increased the maximum permissible dose of cyclophosphamide without affecting its LD(50)and delayed mouse death from cyclophosphamide toxicity. Most mice died only 3 days after combination treatment with the test preparations and cyclophosphamide in doses of LD(16)-LD(84). The second peak of death from hematologic toxicity of cyclophosphamide was absent under these conditions. T-activin and vitamin E did not abolish the antitumor effect of cyclophosphamide on mice with subcutaneously implanted P-388 lympholeukemia. Tumor growth was suppressed by 100%.
Mufazalova
N A
NA
Department of Pharmacology No. 1, Course of Clinical Pharmacology, Bashkirian State Medical University, Ufa. fagimm@mail.ru
Treshchalin
I D
ID
Treshchalina
E M
EM
Sedakova
L A
LA
Andronova
N V
NV
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use / Q000633:toxicity*; D003520:Cyclophosphamide / Q000627:therapeutic use / Q000633:toxicity*; D004359:Drug Therapy, Combination; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D013949:Thymus Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays
D018906:Antineoplastic Agents, Alkylating; D010455:Peptides; D013949:Thymus Extracts; D014810:Vitamin E; C036191:T-activin; D003520:Cyclophosphamide