Biological evaluation of analogues of an insect neuropeptide proctolin.
Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.
Woźnica
Iwona
I
Faculty of Chemistry, University of Wrocław, Wrocław, Poland.
Szeszel-Fedorowicz
Wioletta
W
Rosińskiand
Grzegorz
G
Konopińska
Danuta
D
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D006110:Grasshoppers / Q000187:drug effects / Q000502:physiology; D007313:Insecta; D009479:Neuropeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013712:Tenebrio / Q000187:drug effects / Q000502:physiology
D009479:Neuropeptides; D009842:Oligopeptides; C011536:proctolin