title: Bupropion in the management of apathy.
abstract: We report on three males with prominent apathy as part of the symptom complex of depression or organic brain disease. Significant clinical responses were observed following treatment with bupropion, an antidepressant with dopamine (DA) reuptake activity. We present clinical evidence in support of the hypothesis that remission in these patients occurred as a consequence of bupropion-induced increases in central DA neurotransmission.
authors.affiliation: Department of Psychiatry, Beaumont Hospital, Dublin, Ireland. corcoranciaran@oz.ie
authors.forename: C
authors.initials: C
authors.lastname: Corcoran
authors.forename: M L
authors.initials: ML
authors.lastname: Wong
authors.forename: V
authors.initials: V
authors.lastname: O'Keane
mesh_terms: D000328:Adult; D000368:Aged; D016642:Bupropion / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009042:Motivation; D016896:Treatment Outcome
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion