title: Radiographic parameters for prognosis of periodontal healing of infrabony defects: two different definitions of defect depth.
abstract: BACKGROUND
  The aim of the present study was to evaluate defect width and two different definitions of defect depth as prognostic factors of periodontal healing in infrabony defects treated by regenerative therapy 6 and 24 months after surgery.
  
  
  METHODS
  In 32 patients with moderate to advanced periodontitis, 50 infrabony defects were treated by the guided tissue regeneration (GTR) technique using non-resorbable or bioabsorbable barriers. Clinical parameters were assessed, and 50 triplets of standardized radiographs were taken before surgery and 6 and 24 months after surgery. Using a computer-assisted analysis, the distances cemento-enamel junction (CEJ) to alveolar crest (AC), CEJ to bony defect (BD), horizontal projection of the most coronal extension of the bony wall to the root surface to BD, width, and angle of the bony defects were measured. Depth of the bony defect was 1) calculated as CEJ-BD minus CEJ-AC (INFRA1) and 2) measured as horizontal projection of the most coronal extension of the bony wall to the root surface to BD (INFRA2).
  
  
  RESULTS
  Whereas statistically significant vertical clinical attachment level gains (CAL-V: 3.36 +/- 1.59 mm/ 3.41 +/- 1.72 mm; P < 0.001) could be found both 6 and 24 months after surgery, bony fill (0.70 +/- 2.52 mm; P = 0.056/1.21 +/- 2.55 mm; P < 0.005) was significant 24 months post-surgically only. In a multilevel regression analysis, CAL-V gain was predicted by bioabsorbable membrane (P = 0.005), baseline probing depths (PD) (P < 0.001), and actual smoking (P < 0.05). Bony fill could be predicted by baseline depth of the infrabony component as determined by INFRA2 (P < 0.05), angulation of bony defect (P < 0.005), and gingival index at baseline (P < 0.001). In narrow (< 37 degrees) and deep (> or = 4 mm) infrabony defects, bony fill was more pronounced than in wide and shallow defects (P < 0.001).
  
  
  CONCLUSIONS
  Improvement achieved by GTR in infrabony defects can be maintained up to 24 months after surgery. Narrow and deep infrabony defects respond radiographically and are to some extent clinically more favorable to GTR therapy than are wide and shallow defects. The infrabony component of bony defects, as determined by the distance from the most coronal extension of the lateral bony wall to BD (INFRA2), is a better predictor of bony fill than that determined by AC-BD (INFRA1).
authors.affiliation: Section of Periodontology, Department of Operative Dentistry and Periodontology, Ruprecht-Karls-University, Heidelberg, Germany. peter_eickholz@med.uni-heidelberg.de
authors.forename: Peter
authors.initials: P
authors.lastname: Eickholz
authors.forename: Torten
authors.initials: T
authors.lastname: Hörr
authors.forename: Filip
authors.initials: F
authors.lastname: Klein
authors.forename: Stefan
authors.initials: S
authors.lastname: Hassfeld
authors.forename: Ti-Sun
authors.initials: TS
authors.lastname: Kim
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000145:classification / Q000000981:diagnostic imaging* / Q000601:surgery; D000539:Alveolar Process / Q000000981:diagnostic imaging; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000000981:diagnostic imaging / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000000981:diagnostic imaging / Q000601:surgery; D010518:Periodontitis / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery; D011379:Prognosis; D011859:Radiography; D012044:Regression Analysis; D012907:Smoking; D019237:Tooth Cervix / Q000000981:diagnostic imaging; D014092:Tooth Root / Q000000981:diagnostic imaging; D014945:Wound Healing / Q000502:physiology
chemical_list: D008567:Membranes, Artificial