2,3-diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitors.
A new series of cyclooxygenase-2 (COX-2) inhibitors with gamma-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.
Hyup Joo
Yung
Y
Drug Discovery, AmorePacific Corporation R&D Center, Pharmaceutical & Health Research Institute, 314-1 Bora-ri, Kiheung-eup, Yongin-si, Kyounggi-do 449-729, South Korea. yhjoo@amorepacific.com
Kwan Kim
Jin
J
Kang
Seon-Hwa
SH
Noh
Min-Soo
MS
Ha
Jun-Yong
JY
Kyu Choi
Jin
J
Lim
Kyung Min
KM
Chung
Shin
S
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016861:Cyclooxygenase Inhibitors; D011714:Pyrans