title: Clarithromycin-induced eosinophilic pneumonia.
abstract: Clarithromycin (CAM) has been widely used for the treatment of respiratory infection. Macrolides are generally well tolerated and their adverse reactions are rare. An 80-year-old woman with nontuberculous mycobacterium infection was treated with combined chemotherapy, including isoniazid, rifampicin, and ethambutol. She developed a fever and peripheral blood eosinophilia, and new subpleural consolidations were observed on chest radiography three days after add-on therapy with CAM. The symptoms and clinical findings improved with the withdrawal of CAM. Histopathologic examinations confirmed the diagnosis of eosinophilic pneumonia. This is the first report of CAM-induced eosinophilic pneumonia.
authors.affiliation: Second Department of Internal Medicine, Ehime University School of Medicine, Ehime.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Abe
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Hironobu
authors.initials: H
authors.lastname: Hamada
authors.forename: Ryoji
authors.initials: R
authors.lastname: Ito
authors.forename: Takeru
authors.initials: T
authors.lastname: Hirayama
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Nishimura
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D004804:Eosinophils / Q000502:physiology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D009164:Mycobacterium Infections / Q000188:drug therapy; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin