Linezolid-induced bradycardia: a case report.
We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.
Tartarone
Alfredo
A
Division of Medical Oncology and Haematology, Centro di Riferimento Oncologico della Basilicata, Strada Provinciale No. 8, 85028 Rionero in Vulture (PZ), Italy. tarta1@virgilio.it
Gallucci
Giuseppina
G
Iodice
Giovanni
G
Romano
Giampiero
G
Coccaro
Mariarosa
M
Vigliotti
Maria Luigia
ML
Mele
Giuseppe
G
Matera
Rosella
R
Di Renzo
Nicola
N
D000081:Acetamides / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000188:drug therapy; D006801:Humans; D007565:Jaundice / Q000150:complications / Q000188:drug therapy; D000069349:Linezolid; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid