title: Hemicraniectomy with dural augmentation in medically uncontrollable hemispheric infarction.
abstract: Surgical decompression to alleviate raised intracranial pressure has been reported repeatedly in the past decades in small series of patients. Only recently have there been indications from larger trials that surgical decompression may be beneficial in treating space-occupying hemispheric infarction. However, surgical requirements for the procedure to be effective have not yet been defined. Based on theoretical criteria, the authors operated on 43 patients with medically uncontrollable hemispheric infarctions. The craniectomies were planned to be as large as possible and performed in combination with a subtemporal decompression. Postoperative computerized tomography scans were evaluated for these criteria. The mean survival rate for the group of 43 patients was 72.1% and no surviving patient ended up in a vegetative state. The mean area of craniectomy was found to be 84.3 +/- 16.5 cm2 and the mean distance of the inferior craniectomy margin to the middle fossa was 1.8 +/- 1.3 cm. Comparison of survivors and nonsurvivors failed to show a significant difference in the size of craniectomy or the distance to the floor of the middle fossa. Compared with the reported 80% fatality rate for medically treated stroke patients, in this subgroup the outcome (72.1% survival rate) is remarkably good. The authors conclude that decompressive craniectomy is an effective treatment, able to reduce mortality, and to improve neurological outcome in patients with space-occupying cerebral infarction if the size of craniectomy is large enough. Nevertheless, there is a need for further investigation to identify patients who will benefit from surgery and predictors to optimize the timing of surgical intervention.
authors.affiliation: Department of Neurosurgery, University of Heidelberg Medical School, Heidelberg, Germany.
authors.forename: C R
authors.initials: CR
authors.lastname: Wirtz
authors.forename: T
authors.initials: T
authors.lastname: Steiner
authors.forename: A
authors.initials: A
authors.lastname: Aschoff
authors.forename: S
authors.initials: S
authors.lastname: Schwab
authors.forename: H
authors.initials: H
authors.lastname: Schnippering
authors.forename: H H
authors.initials: HH
authors.lastname: Steiner
authors.forename: W
authors.initials: W
authors.lastname: Hacke
authors.forename: S
authors.initials: S
authors.lastname: Kunze