Endothelial injury in peritoneal dialysis patients with ultrafiltration failure.
To evaluate endothelial injury in peritoneal dialysis patients with ultrafiltration failure (UFF), we performed a modified peritoneal equilibration test utilizing 3.86% glucose in 41 patients who had been on peritoneal dialysis for longer than 4 years. Twelve patients whose net ultrafiltrate was less than 400 mL during a 4-hour exchange were assigned to the UFF group and another 29 patients to the control group. The blood levels of vWF, a marker of endothelial injury, albumin, and lipid profile were measured. The number of antihypertensive medications and amount of 3.86% solution used were higher in the UFF group than those used in the control group (p < 0.05, p < 0.001, respectively). The patients in the UFF group had a significantly higher vWF level than those in the control group (164.8 +/- 23.1% vs. 144.5 +/- 22.4%, p < 0.05). These results showed that peritoneal dialysis patients with ultrafiltration failure had more severe endothelial injury than those without.
Kim
Soon Bae
SB
Department of Internal Medicine, Asian Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea. sbkim@amc.seoul.kr
Lee
Sang Koo
SK
Park
Jung Sik
JS
D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D017211:Treatment Failure; D014462:Ultrafiltration; D014841:von Willebrand Factor / Q000378:metabolism
D008055:Lipids; D012709:Serum Albumin; D014841:von Willebrand Factor