title: Influence of polymerization temperature on the molecular recognition of imprinted polymers.
abstract: This paper aimed at investigating the influence of polymerization temperature on the molecular recognition of molecularly imprinted polymers (MIPs) based on multiple non-covalent interactions. 3-l-Phenylalanylaminopyridine (3-l-PheNHPy) imprinted polymers were prepared using azobisnitriles as either thermal initiators or photoinitiators at various temperatures of 10, 40 and 60 degrees C, respectively. These polymers were subsequently evaluated in the high-performance liquid chromatographic (HPLC) mode for enantioselectivity. An unexpected result shows that polymer prepared at 40 degrees C has the highest enantioselectivity, but not the polymer prepared at lower temperature of 10 degrees C. Further, the effect of elution temperature and sample load on the selectivity of polymers was investigated in detail. In order to get a better understanding of the "exception", the influence of polymerization temperature on the polymerization extent and polymer morphology was studied by FT-IR spectrum test, cross-polarization magic angle spinning (CP-MAS) (13)NMR spectra experiment and pore analysis. Based on these results we attribute this "exception" to that there is a tradeoff between the extent of polymerization and stabilization of the template-functional monomer complexes. And an optimal polymerization temperature can be found for each combination of template and monomer.
authors.affiliation: State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Chenxi
authors.initials: C
authors.lastname: Li
authors.forename: Xudong
authors.initials: X
authors.lastname: Wang
authors.forename: Pingchuan
authors.initials: P
authors.lastname: Sun
authors.forename: Xianghua
authors.initials: X
authors.lastname: Xing
mesh_terms: D002851:Chromatography, High Pressure Liquid; D011108:Polymers / Q000737:chemistry*; D012680:Sensitivity and Specificity; D013696:Temperature
chemical_list: D011108:Polymers