title: A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials.
abstract: Symptoms are an important outcome for measurement in clinical trials into gastro-oesophageal reflux disease, but the optimal approach to symptom assessment has not been formally evaluated. The authors conducted a systematic review to assess how reflux symptoms have been evaluated and how well these correlate with oesophagitis healing and relapse.
authors.affiliation: Gastroenterology Unit, City Hospital, Dudley Road, Winson Green, Birmingham, UK.
authors.forename: N
authors.initials: N
authors.lastname: Sharma
authors.forename: C
authors.initials: C
authors.lastname: Donnellan
authors.forename: C
authors.initials: C
authors.lastname: Preston
authors.forename: B
authors.initials: B
authors.lastname: Delaney
authors.forename: G
authors.initials: G
authors.lastname: Duckett
authors.forename: P
authors.initials: P
authors.lastname: Moayyedi
mesh_terms: D002986:Clinical Trials as Topic; D004941:Esophagitis / Q000188:drug therapy*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D011788:Quality of Life; D012008:Recurrence; D016896:Treatment Outcome