title: Appropriateness of anthropometric obesity indicators in assessment of coronary heart disease risk among Finnish men and women.
abstract: OBJECTIVE
  The aim of the study was to compare the appropriateness of different obesity indicators in the assessment of coronary heart disease (CHD) risk.
  
  
  METHODS
  The study cohort included 11,510 Finnish men and women aged 25 to 64 year at baseline who participated in a cardiovascular disease risk factor survey in 1987 or 1992. At baseline, data on smoking and diabetes were recorded, blood pressure. body mass index (BMI), waist circumference (WC), and waist to hip ratio (WHR) were measured, and serum total and high-density lipoprotein (HDL) cholesterol were determined. A follow-up was done to the end of 1997. Death or diagnosed event from CHD was used as an outcome variable.
  
  
  RESULTS
  At baseline, BMI was the best explaining variable for systolic and diastolic blood pressure (DBP) and for total cholesterol, whereas WC was the best explaining variable for HDL cholesterol, among both men and women. During the follow-up, WHR was the best predictor of CHD incidence. However, after the adjustment for other CHD risk factors none of the obesity indicators remained statistically significant. In both sexes, BMI was a statistically significant predictor of CHD incidence among subjects with DBP lower than the mean. Among men, a similar interaction was seen between DBP and WC.
  
  
  CONCLUSIONS
  WHR was the best predictor of CHD incidence in our data. Abdominal obesity has an effect on CHD incidence independently of general obesity.
authors.affiliation: Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA. silventoinen@epi.umn.edu
authors.forename: Karri
authors.initials: K
authors.lastname: Silventoinen
authors.forename: Pekka
authors.initials: P
authors.lastname: Jousilahti
authors.forename: Erkki
authors.initials: E
authors.lastname: Vartiainen
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000886:Anthropometry; D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity