title: [Acute coronary syndrome (without ST-elevation)].
abstract: Antithrombotic therapy in acute coronary syndrome without ST-segment elevation should be initiated with aspirin 100 mg/day (loading dose 250-500 mg) and Clopidogrel 75 mg/day (loading dose 300 mg). In addition, anticoagulation with unfractionated heparin or low molecular weight heparin should be started. A GP IIb/IIIa receptor blocker can be given either upfront (Eptifibatide/Tirofiban) or directly in the cathlab preceding PCI (Abciximab). Aspirin should be given in the chronic phase lifelong, Clopidogrel for at least nine months. An invasive strategy is recommended in high-risk patients within 48 hours.
authors.affiliation: II. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Rupprecht
authors.forename: S
authors.initials: S
authors.lastname: Genth-Zotz
authors.forename: W
authors.initials: W
authors.lastname: Jungmair
authors.forename: C
authors.initials: C
authors.lastname: Espinola-Klein
authors.forename: S
authors.initials: S
authors.lastname: Blankenberg
authors.forename: F
authors.initials: F
authors.lastname: Post
mesh_terms: D000208:Acute Disease; D000789:Angina, Unstable / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D000925:Anticoagulants / Q000627:therapeutic use*; D003327:Coronary Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D003661:Decision Support Techniques; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010346:Patient Care Management / Q000379:methods; D010818:Practice Patterns, Physicians'; D018570:Risk Assessment / Q000379:methods; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents