TGF beta-1 and neurological function after hypoxia-ischemia in adult rats.
The present study compared the short-term and long-term neuroprotective and neurobehavioral effects of transforming growth factor beta-1 (TGF beta-1) after hypoxic-ischemic injury in adult rats. TGF beta-1 (10 ng) or vehicle were administered intracerebroventricularly (i.c.v.) 2 h after hypoxia-ischemia. Adhesive removal test was assessed after 10 or 40 days, and the neuronal outcome then determined. TGF beta-1 significantly increased the area of intact cortex compared with vehicle 10 days after the injury, with a significant improvement in neurological function. In contrast, after 40 days recovery TGFbeta-1 neither improved neuronal outcome nor neurological function, suggesting TGFbeta-1 can transiently improve functional and histological recovery from hypoxia-ischemia.
Guan
Jian
J
Liggins Institute, Faculty of Medicine and Health Sciences The University of Auckland, Private Bag 92019, Auckland, New Zealand. j.guan@auckland.ac.nz
Miller
Odette T
OT
Waugh
Kevin M
KM
McCarthy
Dianne C
DC
Gluckman
Peter D
PD
Gunn
Alistair J
AJ
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000494:pharmacology / Q000627:therapeutic use*; D053773:Transforming Growth Factor beta1
C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1