NTP-CERHR expert panel report on the reproductive and developmental toxicity of methanol.
The National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in June 1998. The purpose of the Center is to provide timely, unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on reproduction, including development, caused by agents to which humans may be exposed. Methanol was selected for evaluation by the CERHR based on high production volume, extent of human exposure, and published evidence of reproductive or developmental toxicity. Methanol is used in chemical syntheses and as an industrial solvent. It is a natural component of the human diet and is found in consumer products such as paints, antifreeze, cleaning solutions, and adhesives. It is used in race car fuels and there is potential for expanded use as an automobile fuel. This evaluation is the result of a 10-month effort by a 12-member panel of government and non-government scientists that culminated in a public Expert Panel meeting. This report has been reviewed by CERHR staff scientists, and by members of the Methanol Expert Panel. Copies have been provided to the CERHR Core Committee, which is made up of representatives of NTP-participating agencies. This report is a product of the Expert Panel and is intended to (1). interpret the strength of scientific evidence that a given exposure or exposure circumstance may pose a hazard to reproduction and the health and welfare of children; (2). provide objective and scientifically thorough assessments of the scientific evidence that adverse reproductive/development health effects are associated with exposure to specific chemicals or classes of chemicals, including descriptions of any uncertainties that would diminish confidence in assessment of risks; and (3). identify knowledge gaps to help establish research and testing priorities. The expert panel report becomes a central part of the subsequent NTP-CERHR Monograph. Each monograph includes the NTP Brief on the chemical under evaluation, the expert panel report, and all public comments on the expert panel report. The NTP Brief contains the NTP's conclusions on the potential for exposure to result in adverse effects on human development and reproduction. It is based on the expert panel report, public comments on the report, and relevant data published after the expert panel report was completed. NTP-CERHR Monographs are publicly available and are transmitted to appropriate health and regulatory agencies.
Shelby
Michael
M
NIEHS, Research Triangle Park, NC 27709, USA. shelby@niehs.nih.gov
Portier
Christopher
C
Goldman
Lynn
L
Moore
John
J
Iannucci
Annette
A
Jahnke
Gloria
G
Donkin
Steve
S
D000328:Adult; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002658:Developmental Disabilities / Q000139:chemically induced*; D004781:Environmental Exposure; D005260:Female; D006128:Growth / Q000187:drug effects; D000882:Haplorhini; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000139:chemically induced*; D008297:Male; D000432:Methanol / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D051379:Mice; D009153:Mutagens / Q000633:toxicity; D016273:Occupational Exposure; D011247:Pregnancy; D051381:Rats; D018570:Risk Assessment; D012997:Solvents; D013045:Species Specificity; D013723:Teratogens / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*
D002273:Carcinogens; D009153:Mutagens; D012997:Solvents; D013723:Teratogens; D000432:Methanol