Preliminary evaluation of anticonvulsant activity of some 4-(benzyloxy)-benzamides.
A series of alkanolamides have been tested for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure treshold (ScMet) assays and for neurotoxicity (TOX) in rodents. Most interesting were the anticonvulsant results of 2N-methylaminoethanol derivative II, which displayed anti-MES activity (mice) with a protective index (TD50/ED50) of 2.536 higher than that for valproate.
Marona
Henryk
H
Department of Chemical Technology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str,. 30-688 Kraków, Poland. hen.mar@interia.pl
Szneler
Edward
E
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001549:Benzamides / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004597:Electroshock / Q000379:methods; D051379:Mice; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control
D000927:Anticonvulsants; D001549:Benzamides; D001565:Benzoates; C015619:4-benzyloxybenzoic acid