CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta+ T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha.
Madakamutil
Loui T
LT
La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Christen
Urs
U
Lena
Christopher J
CJ
Wang-Zhu
Yiran
Y
Attinger
Antoine
A
Sundarrajan
Monisha
M
Ellmeier
Wilfried
W
von Herrath
Matthias G
MG
Jensen
Peter
P
Littman
Dan R
DR
Cheroutre
Hilde
H
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001117:Arenaviridae Infections / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D002470:Cell Survival; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D020395:Receptors, Interleukin-7 / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology
D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D008562:Membrane Glycoproteins; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain; C028388:thymus-leukemia antigens; D007371:Interferon-gamma