Essential function for ErbB3 in breast cancer proliferation.
The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activity of ErbB2 in breast cancer cells. Importantly, the proliferative signals from this transforming complex appear to act via the PI-3 kinase pathway.
Perez-Nadales
Elena
E
MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, UK.
Lloyd
Alison C
AC