The oxygen stress index and levels of circulating interleukin-10 and interleukin-6 in patients with chronic heart failure.
OBJECTIVE
We sought to study circulating levels of pro- and anti-inflammatory cytokines together with the oxygen stress index in patients with chronic heart failure (CHF).


BACKGROUND
Patients with CHF exhibit elevated levels of inflammatory and anti-inflammatory cytokines but the relative level of these cytokines with the oxygen stress index have not been reported.


METHODS
Twenty-two patients with CHF and 10 control subjects were studied. Plasma levels of IL-6 and IL-10 were determined and the oxygen stress index was evaluated by urine 8-iso-PGF2alpha estimations.


RESULTS
Plasma levels of IL-6 and IL-10 in CHF patients were significantly higher than those observed in the control subjects. Patients with more advanced disease (higher NYHA class) showed higher concentrations of IL-10 and IL-6 than those with less serious disease. 8-iso-PGF2alpha urine concentration (and therefore the oxygen stress index) was significantly higher in patients with CHF in comparison with control subjects. IL-6 plasma levels, but not IL-10 concentrations, correlated significantly with 8-iso-PGF2alpha levels in urine.


CONCLUSIONS
Inflammatory and anti-inflammatory cytokine levels, as well as the oxidative stress index, are increased in patients with chronic heart failure. Inflammatory cytokine IL-6, but not anti-inflammatory cytokine Il-10, levels correlated significantly with the oxygen stress index.
Wykretowicz
Andrzej
A
Department of Cardiology-Intensive Therapy, University School of Medicine, 49 Przybyszewskiego, 60-355 Poznan, Poland. awykreto@ptkardio.pl
Furmaniuk
Jaromir
J
Smielecki
Juliusz
J
Deskur-Smielecka
Ewa
E
Szczepanik
Adam
A
Banaszak
Agnieszka
A
Wysocki
Henryk
H
D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000276:immunology; D003324:Coronary Artery Disease / Q000150:complications / Q000276:immunology; D015237:Dinoprost / Q000276:immunology / Q000652:urine; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology*
D015850:Interleukin-6; D016753:Interleukin-10; D015237:Dinoprost