Chromatin domains and territories: flexibly rigid.
The nucleus is a highly organized solid-state system, rigid and flexible at the same time, where enzymes are organized in complex processing factories. This is achieved by the organization of nuclear DNA into territories and domains, which allow compartmentalization and compaction without sacrificing accessibility. The present review discusses the implications of the organization of chromosomal domains and territories in development and carcinogenesis.
Razin
Sergey V
SV
Institute of Gene Biology, Russian Academy of Sciences, 117334 Moscow, Russia. sergery.v.razin@usa.net
Petrov
Andrei
A
Hair
Alan
A
Vassetzky
Yegor S
YS
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D045584:Chromosome Positioning / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics; D013692:Telophase; D014158:Transcription, Genetic; D014982:Xenopus laevis / Q000254:growth & development
D002843:Chromatin