Biaryl amide glucagon receptor antagonists.
Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.
Kurukulasuriya
Ravi
R
Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. ravi.kurukulasuriya@abbott.com
Sorensen
Bryan K
BK
Link
James T
JT
Patel
Jyoti R
JR
Jae
Hwan-Soo
HS
Winn
Marty X
MX
Rohde
Jeffrey R
JR
Grihalde
Nelson D
ND
Lin
Chun W
CW
Ogiela
Christopher A
CA
Adler
Andrew L
AL
Collins
Christine A
CA
D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000882:Haplorhini; D006801:Humans; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D018027:Receptors, Glucagon / Q000037:antagonists & inhibitors*
D000577:Amides; D018027:Receptors, Glucagon