Iron, oxidative stress, and disease risk.
Based on epidemiologic evidence citing excess iron as a risk factor for many diseases, and oxidative stress as an underlying cause for those diseases, iron-induced oxidative stress has recently gained attention. Although iron can participate in oxidative reactions to generate free radicals under in vitro conditions, its involvement in vivo in the cause or progression of diseases is questionable.
Reddy
Manju B
MB
Department of Food Science and Human Nutrition, Center for Designing Foods to Improve Nutrition, 1127 HNSB, Iowa State University, Ames, IA 50011, USA.
Clark
Laura
L
D006331:Heart Diseases / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000009:adverse effects*; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology; D018384:Oxidative Stress / Q000502:physiology*; D012307:Risk Factors
D007501:Iron