Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil.
This study analysed and compared the effects of chronic oral treatment with quercetin or verapamil on systolic blood pressure and vascular function in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Quercetin and verapamil inhibited the development of DOCA-salt-induced hypertension in a similar manner. DOCA-salt-hypertensive rats showed potassium depletion and oxidative stress, prevented only by concomitant quercetin administration. Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats. In conclusion, quercetin and verapamil show similar antihypertensive effects in mineralocorticoid hypertension, but quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation, suggesting a better vascular protection in this volume expansion hypertension model.
Galisteo
Milagros
M
Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.
García-Saura
María Francisca
MF
Jiménez
Rosario
R
Villar
Inmaculada Concepción
IC
Wangensteen
Rosemary
R
Zarzuelo
Antonio
A
Vargas
Félix
F
Duarte
Juan
J
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal; D011189:Potassium Chloride; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride; D014700:Verapamil / Q000494:pharmacology
D000959:Antihypertensive Agents; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D011189:Potassium Chloride; D011794:Quercetin; D014700:Verapamil