Systemic thrombolytic therapy for late-onset portal vein thrombosis after living-donor liver transplantation.
BACKGROUND
There have been few reports of noninvasive treatment for portal vein thrombosis (PVT) after liver transplantation.


METHODS
One adult patient and four pediatric patients developed PVT 5, 14, 14, 16, and 43 months after living-donor liver transplantation, respectively. All five of the patients received a 10-day course of systemic thrombolytic therapy with recombinant tissue plasminogen activator.


RESULTS
After the treatment was completed, successful portal vein recanalization was demonstrated on ultrasonography or multidetector three-dimensional computed tomography angiography in all five cases.


CONCLUSIONS
Noninvasive treatment with systemic recombinant tissue plasminogen activator should be considered for selected patients with late-onset PVT after liver transplantation.
Takatsuki
Mitsuhisa
M
Department of Surgery, Chang Gung University, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Kaohsiung, Taiwan.
Chen
Chao-Long
CL
Chen
Yaw-Sen
YS
Cheng
Yu-Fan
YF
Huang
Tung-Liang
TL
D000328:Adult; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D011169:Portal Vein; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D020246:Venous Thrombosis / Q000188:drug therapy*
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator