title: Sterol regulatory element-binding protein (SREBP)-1: gene regulatory target for insulin resistance?
abstract: The combined appearance of different cardiovascular risk factors seems to be more prevalent in individuals with decreased insulin sensitivity and increased visceral obesity, thereby being components of the so-called metabolic syndrome. Alterations in transcription factors result in complex dysregulation of gene expression, which might be the key to understanding insulin resistance-associated clinical clustering of coronary risk factors at the cellular or gene regulatory level. Recent examples are peroxisome proliferator-activated receptors and sterol regulatory element-binding proteins (SREBPs), which also appear to be novel drug targets. The authors have recently shown that SREBPs are substrates of mitogen-activated protein kinases, and propose that SREBP-1 might play a role in the development of cellular features belonging to lipotoxicity and, possibly, syndrome X.
authors.affiliation: Klinische Biochemie und Pathobiochemie, Deutsches Diabetes-Forschungsinstitut, Leibniz-Institut an der Heinrich-Heine-Universität Düsseldorf, Germany.
authors.forename: Jorg
authors.initials: J
authors.lastname: Kotzka
authors.forename: Dirk
authors.initials: D
authors.lastname: Müller-Wieland
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics* / Q000502:physiology; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics* / Q000378:metabolism*
chemical_list: D051780:Sterol Regulatory Element Binding Protein 1