Effect of diet on mucin kinetics and composition: nutrition and health implications.
The mucus gel covering the gut epithelium is in dynamic balance between synthesis and secretion of mucin from goblet cells and proteolytic and physical erosion that releases mucin into the lumen. In the lumen, mucin is partially protected from proteolysis by carbohydrate chains, and it contributes to endogenous protein reaching the ileum. Dietary components modulate the contribution of mucin to endogenous protein components and their qualitative composition. In addition, mucin plays a key role in gastrointestinal protection in association with the microflora. In this review, we will attempt to evaluate the consequences of dietary manipulation of mucin on gut health.
Montagne
L
L
Joint Unit of Research Calf and Pig, National Institute for Agricultural Research (INRA)/Agrocampus Rennes, 65 rue de Saint Brieuc, CS 84215, 35042 Rennes Cedex, France.
Piel
C
C
Lallès
J P
JP
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004032:Diet; D004064:Digestive System / Q000382:microbiology; D004068:Digestive System Physiological Phenomena; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000502:physiology*; D009077:Mucins / Q000378:metabolism / Q000502:physiology*; D009093:Mucus / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
D009077:Mucins; D011506:Proteins