Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans.
OBJECTIVE
To examine the effects of two different conjugated linoleic acid (CLA) isomers at two different intakes on body composition in overweight humans.


METHODS
Eighty-one middle-aged, overweight, healthy men and women participated in this bicentric, placebo-controlled, double-blind, randomized study. For 6 weeks (run-in period), all subjects consumed daily a drinkable dairy product containing 3 g of high oleic acid sunflower oil. Volunteers were then randomized over five groups receiving daily either 3 g of high oleic acid sunflower oil, 1.5 g of cis-9,trans-11 (c9t11) CLA, 3 g of c9t11 CLA, 1.5 g of trans-10,cis-12 (t10c12) CLA, or 3 g of t10c12 CLA administrated as triacylglycerol in a drinkable dairy product for 18 weeks. Percentage body fat mass and fat and lean body mass were assessed at the end of the run-in and experimental periods by DXA. Dietary intake was also recorded.


RESULTS
Body fat mass changes averaged 0.1 +/- 0.9 kg (mean +/- SD) in the placebo group and -0.3 +/- 1.4, -0.8 +/- 2.1, 0.0 +/- 2.3, and -0.9 +/- 1.7 kg in the 1.5-g c9t11, 3-g c9t11, 1.5-g t10c12, and 3-g t10c12 groups, respectively. Changes among the groups were not significantly different (p = 0.444). Also, lean body mass and dietary intake were not significantly different among the treatments.


CONCLUSIONS
A daily consumption of a drinkable dairy product containing up to 3 g of CLA isomers for 18 weeks had no statistically significant effect on body composition in overweight, middle-aged men and women.
Malpuech-Brugère
Corinne
C
Unité du Métabolisme Protéino-Energétique, Université d'Auvergne/Institut National de la Recherche Agronomique, Centre de Recherche en Nutrition Humaine Auvergne, Clermont Ferrand, France. corinne.brugere@clermont.inre.fr
Verboeket-van de Venne
Wilhelmine P H G
WP
Mensink
Ronald P
RP
Arnal
Marie-Agnès
MA
Morio
Béatrice
B
Brandolini
Marion
M
Saebo
Asgeir
A
Lassel
Taous S
TS
Chardigny
Jean Michel
JM
Sébédio
Jean Louis
JL
Beaufrère
Bernard
B
D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D001628:Beverages; D001823:Body Composition / Q000187:drug effects*; D015992:Body Mass Index; D001835:Body Weight; D003611:Dairy Products; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000008:administration & dosage; D010919:Placebos; D010938:Plant Oils / Q000008:administration & dosage; D000074242:Sunflower Oil; D014280:Triglycerides / Q000008:administration & dosage
D004042:Dietary Fats, Unsaturated; D044243:Linoleic Acids, Conjugated; D010919:Placebos; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D019301:Oleic Acid