title: Granulocytic sarcoma in children.
abstract: We report three children with leukaemia (two acute myeloid and one acute lymphoblastic) and granulocytic sarcoma in the skull, orbit and sinuses. Lesions in these sites in children, with or without bone changes, are suggestive of systemic diseases such as lymphoproliferative conditions. Although involvement by granulocytic sarcoma, with or without acute myeloid leukaemia, is described, an association with acute lymphoblastic leukaemia is rare. Recognition of this rare entity is important, because early aggressive chemotherapy can bring about regression of the tumour and improve survival.
authors.affiliation: Institut für Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universität, Schleusenweg 2-16, 60528 Frankfurt am Main, Germany. Stalmann.Porto@t-online.de
authors.forename: L
authors.initials: L
authors.lastname: Porto
authors.forename: M
authors.initials: M
authors.lastname: Kieslich
authors.forename: D
authors.initials: D
authors.lastname: Schwabe
authors.forename: F E
authors.initials: FE
authors.lastname: Zanella
authors.forename: H
authors.initials: H
authors.lastname: Lanfermann
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009918:Orbital Neoplasms / Q000473:pathology* / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000473:pathology* / Q000628:therapy; D023981:Sarcoma, Myeloid / Q000473:pathology* / Q000628:therapy; D012888:Skull Neoplasms / Q000473:pathology* / Q000628:therapy