Do amyloids remember their origin? New insights into the prion species barrier.
Excellent work demonstrates that, in the test tube, prion protein itself is responsible for its species specificity, although questions remain about whether this occurs in the same way in the organism.
Chernoff
Yury O
YO
School of Biology and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA.
D000682:Amyloid / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002353:Carrier State / Q000635:transmission / Q000662:veterinary; D006224:Cricetinae; D006801:Humans; D051379:Mice; D008954:Models, Biological; D017096:Prion Diseases / Q000209:etiology* / Q000235:genetics / Q000378:metabolism / Q000635:transmission*; D011328:Prions / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D013045:Species Specificity; D015047:Zoonoses
D000682:Amyloid; D011328:Prions; D020033:Protein Isoforms