title: Skin compatibility of cyclodextrins and their derivatives: a comparative assessment using a corneoxenometry bioassay.
abstract: Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on human stratum corneum to compare the skin compatibility of CD currently used in pharmaceutical preparations (betaCD, gammaCD, Rameb, Dimeb, Trimeb, HP-betaCD and HP-gammaCD) and that of new amphiphilic CD derivatives, namely, the phospholipidyl-CD (DMPE-Dimeb and DMPE-Trimeb). All the tested CD were well tolerated by the stratum corneum at a concentration of 5%. However, inter-individual reactivity was larger for DMPE-Dimeb, suggesting a more aggressive trend for this compound. Cutaneous Index of Mildness values obtained confirm that Dimeb is able to extract some skin components and shows that DMPE-Dimeb performs similarly.
authors.affiliation: Department of Pharmacy, University of Liège, Liège, Belgium. geraldine.piel@ulg.ac.be
authors.forename: G
authors.initials: G
authors.lastname: Piel
authors.forename: S
authors.initials: S
authors.lastname: Moutard
authors.forename: E
authors.initials: E
authors.lastname: Uhoda
authors.forename: F
authors.initials: F
authors.lastname: Pilard
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
authors.forename: B
authors.initials: B
authors.lastname: Perly
authors.forename: L
authors.initials: L
authors.lastname: Delattre
authors.forename: B
authors.initials: B
authors.lastname: Evrard
mesh_terms: D003505:Cyclodextrins / Q000138:chemical synthesis / Q000633:toxicity*; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects*; D006801:Humans; D010714:Phosphatidylethanolamines / Q000138:chemical synthesis; D012867:Skin / Q000166:cytology / Q000187:drug effects*; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D003505:Cyclodextrins; D010714:Phosphatidylethanolamines; D015262:Xenobiotics; C018525:1,2-dimyristoylphosphatidylethanolamine