title: A comparison of two intensities of psychosocial intervention for alcohol dependent patients treated with acamprosate.
abstract: OBJECTIVE
  To compare two levels of psychosocial intervention in combination with acamprosate medication for the treatment of alcohol dependence.
  
  
  METHODS
  Patients (n = 70) were prescribed acamprosate and randomized to Minimal Psychosocial Intervention (MPI) or Extended Psychosocial Intervention (EPI). MPI patients met a psychiatrist for 20-30 min sessions on four occasions during a 6 month period. EPI patients were offered 10-15 sessions with a psychiatric nurse in addition to the visits to the psychiatrist. EPI patients were trained to use behavioural and cognitive coping skills to deal with high-risk situations in line with a manual developed for relapse prevention. Patients were assessed four times during the 24-week study by self-report and laboratory tests.
  
  
  RESULTS
  Patients on average reported a decline in days with heavy drinking and in cumulative number of drinking days. No significant differences between patients in MPI and EPI were found with respect to heavy drinking, cumulative number of drinking days, number of days to first drink, or biomarkers of alcohol consumption. Higher age and lower level of education were significant predictors of treatment success.
  
  
  CONCLUSIONS
  Adding more intensive individual treatments appears to add no extra improvement beyond that obtained by prescribing acamprosate and offering an infrequent consultation with a physician.
authors.affiliation: Department of Clinical Neuroscience, Alcohol and Drug Dependence Research, Karolinska Institutet, Stockholm. anders.hammarberg@previa.se
authors.forename: Anders
authors.initials: A
authors.lastname: Hammarberg
authors.forename: Peter
authors.initials: P
authors.lastname: Wennberg
authors.forename: Olof
authors.initials: O
authors.lastname: Beck
authors.forename: Johan
authors.initials: J
authors.lastname: Franck
mesh_terms: D000077443:Acamprosate; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011613:Psychotherapy / Q000379:methods* / Q000706:statistics & numerical data; D012944:Social Support; D012959:Socioeconomic Factors; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D013654:Taurine; D000077443:Acamprosate