Cooperative metal-coordination and ion pairing in tripeptide recognition.
[structure: see text] The recognition of tripeptides by a metal-centered receptor consisting of a rigid backbone region and variable tripeptide arms is described. The studies showed that the receptor was selective for l-Xxx-l-Lys-l-Lys, with Xxx = His, Cys, and Met, giving association constants near 1.0 x 10(6) M(-)(1). Binding enhancement through cooperative interactions of the peptidic arms is demonstrated.
Wright
Aaron T
AT
Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712-0165, USA.
Anslyn
Eric V
EV
D000596:Amino Acids / Q000737:chemistry; D001665:Binding Sites; D002240:Carbohydrate Sequence; D003300:Copper / Q000737:chemistry; D007477:Ions / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*
D000596:Amino Acids; D007477:Ions; D008670:Metals; D009842:Oligopeptides; D009942:Organometallic Compounds; D003300:Copper