HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells.
We recently reported that HLA-G1-transfected antigen-presenting cells (HLA-G1+ APCs) were capable of inhibiting alloproliferative responses. The aim of the present work was to further study the function and the mechanisms of action of HLA-G1+ APCs. We show here that HLA-G1+ APCs are immunoinhibitory cells that (i) inhibit the proliferation of CD4+ T cells, (ii) shed HLA-G1 molecules that might provide extra, non-antigen-specific, inhibitory or proapoptotic signals, (iii) induce CD4+ T cell anergy, or at least long-term unresponsiveness, and (iv) cause the differentiation of CD4+ T cells into suppressive cells. Thus, HLA-G+ APCs might (i) be involved in the direct suppression of immune responses and (ii) contribute to long-term efficient immune escape or tolerance.
LeMaoult
Joël
J
Service de Recherches en Hémato-Immunologie, Commissariat à L'Energie Atomique Departement de Recherche Medicale-Direction des Sciences du Vivant, Hôpital Saint Louis, 1 Avenue Claude Vellefaux, 75475 Paris 10, France.
Krawice-Radanne
Irène
I
Dausset
Jean
J
Carosella
Edgardo D
ED
D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology / Q000502:physiology*
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I