title: Post-genomics of lactic acid bacteria and other food-grade bacteria to discover gut functionality.
abstract: Recent years have seen an explosion in the number of complete or almost complete genomic sequences of lactic acid bacteria and other food-grade bacteria that are used in functional foods to increase the health of the consumer. These have been instrumental in the development of functional, comparative and other post-genomics approaches that provide the possibility to detect, unravel and understand their functionality in the human intestinal tract. In conjunction with other high-throughput approaches, these advances can be exploited in the functional food innovation cycle for developing new or designed probiotic and other bacterial products that impact gut health.
authors.affiliation: Wageningen Center for Food Sciences and Laboratory of Microbiology, Diedenweg 20, PO Box 557, 6700 AN, Wageningen, The Netherlands. willem.devos@wur.nl
authors.forename: Willem M
authors.initials: WM
authors.lastname: de Vos
authors.forename: Peter A
authors.initials: PA
authors.lastname: Bron
authors.forename: Michiel
authors.initials: M
authors.lastname: Kleerebezem
mesh_terms: D000818:Animals; D004064:Digestive System / Q000378:metabolism / Q000382:microbiology*; D005516:Food Microbiology; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods; D006094:Gram-Positive Bacteria / Q000235:genetics* / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans