Rapid access to azepine-fused oxetanols from alkoxy-substituted maleimides.
[reaction: see text] UV irradiation of alkoxy-substituted N-alkenylmaleimides induces a sequence involving a [5 + 2] cycloaddition followed by a Norrish-Yang cyclization. The resulting highly strained alkylidene oxetanol-fused azepines are formed in good yield and with high diastereoselectivities
Booker-Milburn
Kevin I
KI
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK. k.booker-milburn@bristol.ac.uk
Baker
James R
JR
Bruce
Ian
I