Pentacyclic triterpenoids and their cytotoxicity from the stem bark of Styrax japonica S. et Z.
The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol-3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.
Kim
Mi-Ran
MR
Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea.
Lee
Hyang-Hee
HH
Hahm
Kyung-Soo
KS
Moon
Young-Hee
YH
Woo
Eun-Rhan
ER
D045744:Cell Line, Tumor; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems; D032362:Styrax; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
D010936:Plant Extracts; D014315:Triterpenes