The effects of dietary factors on the androgen receptor and related cellular factors in prostate cancer.
It has been strongly suggested that androgens and the cognate receptor (AR) may play important roles in the development and progression of prostate cancer. The AR is a transcription factor consisting of three major domains, i.e., N-terminal transactivation, middle DNA binding, and C-terminal steroid binding domains. Molecular events of androgen induced activation of the AR include conformation change, phosphorylation, acetylation, genomic DNA binding, and co-regulator recruiting. Many of these events can be manipulated in certain prostate cancer cells in favor of their progression. Dietary compounds and certain herbs have recently drawn a great deal of attention because of their relevance to development of several cancers including prostate cancer. We discuss in depth the findings from our and other laboratories of effects of dietary factors or herbs on the function of the AR and potential mechanisms on expression of the AR and AR regulated genes. We further discuss the potential implication of these dietary chemicals on prevention of development and progression of prostate cancer.
Young
Charles Y F
CY
Department of Urology, Mayo Medical Graduate School and Mayo Graduate School, Mayo Clinic/Foundation, Rochester, Minnesota, 55905, USA. youngc@mayo.edu
Jatoi
Aminah
A
Ward
John F
JF
Blute
Michael L
ML
D000728:Androgens / Q000502:physiology; D004032:Diet; D018450:Disease Progression; D006801:Humans; D008297:Male; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D011467:Prostate / Q000502:physiology; D011471:Prostatic Neoplasms / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation / Q000502:physiology
D000728:Androgens; D011944:Receptors, Androgen