[Genistein: a soy isoflavone revealing a pleiotropic mechanism of action - clinical implications in the treatment and prevention of cancer].
Genistein, a naturally occurring isoflavonoid, displays antitumor, antimetastatic and antiangiogenic properties, described in various experimental in vitro and in vivo models. The results of several epidemiological studies suggest that soybean consumption may contribute to lower incidence of breast, colon, prostate, thyroid, and head and neck cancers. This protective effect of soy consumption is attributed, among others, to genistein. On the other hand, genistein may enhance the proliferation of some estrogen-positive human breast cancer cells in vivo and the growth of mammary gland and mammary cancer cells in athymic mice. In this paper, various aspects of the diverse biological activities of genistein and their potential clinical implications, especially in the treatment and prevention of cancer, are reviewed and discussed.
Radzikowski
Czesław
C
Zakład Immunologii Nowotworów, Instytutu Immunologii i Terapii Doświadczalnej im. L. Hirszfelda, PAN we Wrocławiu.
Wietrzyk
Joanna
J
Grynkiewicz
Grzegorz
G
Opolski
Adam
A
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004067:Digestive System Neoplasms / Q000517:prevention & control; D004195:Disease Models, Animal; D019833:Genistein / Q000494:pharmacology*; D006258:Head and Neck Neoplasms / Q000517:prevention & control; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008819:Mice, Nude; D051381:Rats; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D020845:Selective Estrogen Receptor Modulators; D019833:Genistein