Cutaneous T-cell lymphoma in a 21-year-old male with Wolf-Hirschhorn syndrome.
We describe a case of cutaneous T-cell lymphoma occurring in a 21-year-old male with Wolf-Hirschhorn syndrome (WHS) due to a chromosome 4p16.3 deletion. This is the first documented case report of malignancy occurring in an adult with WHS. We also review the literature regarding patients with WHS and the joint occurrence of malignancy and discuss genetic changes involving chromosome 4 which may have contributed to the genesis of our patient's lymphoma.
Batton
Beau
B
William Beaumont Hospital, Department of Pediatrics, Royal Oak, Michigan.
Amanullah
Adoor
A
William Beaumont Hospital, Department of Hematology and Oncology, Royal Oak, Michigan.
Main
Charles
C
William Beaumont Hospital, Department of Hematology and Oncology, Royal Oak, Michigan.
Fivenson
David
D
Henry Ford Health System, Department of Dermatology, Detroit, Michigan.
Jamil
Samir
S
William Beaumont Hospital, Department of Hematology and Oncology, Royal Oak, Michigan.
D000015:Abnormalities, Multiple / Q000235:genetics; D000328:Adult; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000150:complications* / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D004817:Epidermis / Q000473:pathology; D006801:Humans; D007120:Immunochemistry; D008214:Lymphocytes / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D017731:Lymphomatoid Papulosis / Q000473:pathology; D008297:Male; D013577:Syndrome