title: [Chronic abdominal pain due to bowel ischemia in a patient with Leiden factor V mutation].
abstract: Leiden Factor V mutation, associated with resistance to activated protein C, is a prothrombotic state found in 20% of the patients with a first episode of deep-vein thrombosis. We report the case of a 30-Year-old woman with a history of intermittent abdominal pain who developed small bowel infarction requiring extensive small bowel resection. Biological search for prothrombotic disorder showed resistance to activated protein C due to homozygosity for the factor V Leiden mutation. Long-term anticoagulant therapy was initiated. Unexplained abdominal pain may be due to venous mesenteric ischemia, which can be associated with factor V Leiden mutation.
authors.affiliation: Service de Médecine Interne et d'Hépatogastroentérologie, Centre Hospitalier Intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil.
authors.forename: Ariane
authors.initials: A
authors.lastname: Chryssostalis
authors.forename: Hervé
authors.initials: H
authors.lastname: Hagège
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rosa-Hezode
authors.forename: Philippe
authors.initials: P
authors.lastname: Cattan
authors.forename: Isabelle
authors.initials: I
authors.lastname: De Lacroix-Szmania
authors.forename: Patrick
authors.initials: P
authors.lastname: Cabanis
authors.forename: Nazanin
authors.initials: N
authors.lastname: Bayani
authors.forename: Issam
authors.initials: I
authors.lastname: Abd Alsamad
authors.forename: Michel
authors.initials: M
authors.lastname: Chousterman
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D020016:Activated Protein C Resistance / Q000150:complications*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000209:etiology* / Q000473:pathology; D007511:Ischemia / Q000209:etiology*; D017354:Point Mutation
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V