Solid-phase syntheses of furopyridine and furoquinoline systems.
[reaction: see text] Syntheses of 2-substituted furo[3,2-b]pyridines and furo[3,2-h]quinolines have been achieved for the first time in the solid-phase mode. The central enabling steps involved concomitant deprotection/cyclization promoted by the mild base K(2)CO(3). Reactions were monitored "in situ" in real time by a variety of spectroscopic techniques, which allowed full and accurate control of progress in these syntheses.
Cironi
Pablo
P
Biomedical Research Institute, Barcelona Scientific Park, Laboratory of Organic Chemistry, Faculty of Pharmacy, and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain.
Tulla-Puche
Judit
J
Barany
George
G
Albericio
Fernando
F
Alvarez
Mercedes
M
D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D011725:Pyridines; D011804:Quinolines