title: Discovery of novel nonsteroidal glucocorticoid receptor modulators.
abstract: A new class of selective nonsteroidal glucocorticoid receptor modulators typified by N-[3-[benzyl-(4-chloro-2-fluoro-benzyl)-amino]-2-methyl-phenyl]-methanesulfonamide 19 has been discovered.
authors.affiliation: Metabolic Disease Research, Abbott Laboratories, Department 4CB, Bldg. AP-10, Rm. L-14, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. james.link@abbott.com
authors.forename: J T
authors.initials: JT
authors.lastname: Link
authors.forename: Bryan K
authors.initials: BK
authors.lastname: Sorensen
authors.forename: Jyoti
authors.initials: J
authors.lastname: Patel
authors.forename: Maurice
authors.initials: M
authors.lastname: Emery
authors.forename: Marlena
authors.initials: M
authors.lastname: Grynfarb
authors.forename: Annika
authors.initials: A
authors.lastname: Goos-Nilsson
mesh_terms: D000818:Animals; D001593:Benzyl Compounds; D006801:Humans; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides
chemical_list: D001593:Benzyl Compounds; C494076:N-(3-(benzyl-(4-chloro-2-fluoro-benzyl)-amino)-2-methyl-phenyl)-methanesulfonamide; D011965:Receptors, Glucocorticoid; D013449:Sulfonamides