title: Adenovirus infection in hospitalized immunocompetent children.
abstract: This study investigated the clinical features of immunocompetent children with adenovirus infection requiring hospitalization. The files of 78 children (mean age 17 +/- 10 months) with community-acquired adenovirus infection admitted over a 2-year period were reviewed. The children were referred after 5.7 +/- 3.4 days of illness, all with fever (mean peak 39.8 +/- 0.8 degrees C). Temperature normalized after 3.5 +/- 2 days. Duration of hospitalization (mean, 7.0 +/- 3.9 days) correlated with lethargy, lung crackles, cracked lips, hypoxia, impaired liver tests, and high serum lactic dehydrogenase (LDH) concentration at admission. Serum LDH concentrations and hypoxemia predicted 70% of the variance in hospital stay. All patients recovered. Adenovirus infection may cause considerable morbidity, even in immunocompetent children. Disease severity, defined by duration of hospitalization, correlates with serum LDH concentrations and oxygen saturation at admission.
authors.affiliation: Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
authors.forename: Nir
authors.initials: N
authors.lastname: Peled
authors.forename: Charles
authors.initials: C
authors.lastname: Nakar
authors.forename: Henri
authors.initials: H
authors.lastname: Huberman
authors.forename: Edna
authors.initials: E
authors.lastname: Scherf
authors.forename: Zmira
authors.initials: Z
authors.lastname: Samra
authors.forename: Yaron
authors.initials: Y
authors.lastname: Finkelstein
authors.forename: Vered
authors.initials: V
authors.lastname: Hoffer
authors.forename: Ben-Zion
authors.initials: BZ
authors.lastname: Garty
mesh_terms: D000258:Adenovirus Infections, Human / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002673:Child, Hospitalized / Q000706:statistics & numerical data; D002675:Child, Preschool; D003967:Diarrhea / Q000473:pathology; D006760:Hospitalization; D006801:Humans; D006836:Hydro-Lyases / Q000097:blood; D016867:Immunocompromised Host; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D012720:Severity of Illness Index
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D006836:Hydro-Lyases; C045581:lactate dehydratase