title: Reassessing autotransplantation for acute myeloid leukaemia in first remission - a matched pair analysis of autologous marrow vs peripheral blood stem cells.
abstract: The role of autologous stem cell transplantation in adult patients with acute myeloid leukaemia (AML) in first remission is unclear, yet it has become standard treatment for myeloma and this paper explores whether the source of transplanted stem cells may explain this paradox. In total, 57 patients from the Royal Marsden Hospital who received an unpurged bone marrow transplant (ABMT) were matched with 114 patients from the EBMT registry who had undergone peripheral blood stem cell transplantation (PBSCT). Patients were matched for karyotype, FAB type, remission-autograft interval and age. In the PBSCT group, haematopoietic recovery was significantly faster and nonrelapse mortality at 4 years was significantly lower (13 vs 1%, P=0.04). The relapse rate and overall survival at 4 years (20 vs 31% and 77 vs 63%) were also better with PBSCT, although the differences were not statistically significant. Autografting should be reassessed in a randomised trial for first remission AML patients using peripheral blood as a source of stem cells rather than bone marrow.
authors.affiliation: Royal Marsden Hospital and Institute of Cancer Research Surrey, UK.
authors.forename: B
authors.initials: B
authors.lastname: Sirohi
authors.forename: R
authors.initials: R
authors.lastname: Powles
authors.forename: S
authors.initials: S
authors.lastname: Kulkarni
authors.forename: C
authors.initials: C
authors.lastname: Rudin
authors.forename: F
authors.initials: F
authors.lastname: Frassoni
authors.forename: A
authors.initials: A
authors.lastname: Bacigalupo
authors.forename: S
authors.initials: S
authors.lastname: Singhal
authors.forename: S
authors.initials: S
authors.lastname: Vaidya
authors.forename: M
authors.initials: M
authors.lastname: Labopin
authors.forename: M
authors.initials: M
authors.lastname: Michallet
authors.forename: D
authors.initials: D
authors.lastname: Blaise
authors.forename: J
authors.initials: J
authors.lastname: Reiffers
authors.forename: G
authors.initials: G
authors.lastname: Meloni
authors.forename: B
authors.initials: B
authors.lastname: Rio
authors.forename: J
authors.initials: J
authors.lastname: Treleaven
authors.forename: C
authors.initials: C
authors.lastname: Horton
authors.forename: J
authors.initials: J
authors.lastname: Mehta
mesh_terms: D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000706:statistics & numerical data*; D006410:Hematopoiesis; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000628:therapy*; D016555:Matched-Pair Analysis; D036102:Peripheral Blood Stem Cell Transplantation / Q000706:statistics & numerical data*; D011336:Probability; D012008:Recurrence; D012042:Registries; D012074:Remission Induction; D015996:Survival Rate; D013997:Time Factors; D014182:Transplantation, Autologous