title: Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer.
abstract: OBJECTIVE
  This study aimed to observe the expressions of Y box-binding protein-1 (YB-1) and P-glycoprotein (P-gp) in primary ovarian tumor and to determine whether they act as biomarkers for survival in epithelial ovarian cancer.
  
  
  METHODS
  The expressions of YB-1 and P-gp were examined immunohistochemically in 59 patients who were treated from 1997 to 2000 at Kurume University Hospital. Samples were paraffin-embedded primary ovarian cancer tissue taken from the surgical specimens.
  
  
  RESULTS
  Of the 59 primary ovarian tumors examined, 32 (54.2%) and 18 (30.5%) were positive for YB-1 and P-gp, respectively. Co-expression of these two proteins was observed in 20.3% (12/59) cases. Patients showing this co-expression had a worse 3-year survival than those without co-expression (40.0% vs. 73.1%, P = 0.0447). This co-expression significantly correlated with poor prognosis according to multivariate analysis (P = 0.0007).
  
  
  CONCLUSIONS
  Co-expression of YB-1 and P-gp emerged as a promising relevant biomarker for unfavorable prognosis in ovarian cancer.
authors.affiliation: Department of Gynecology, Cancer Hospital, Shanghai Fudan University, Shanghai, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Huang
authors.forename: Kimio
authors.initials: K
authors.lastname: Ushijima
authors.forename: Kan
authors.initials: K
authors.lastname: Komai
authors.forename: Yumi
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Motoshima
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kamura
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Kohno
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D022762:CCAAT-Enhancer-Binding Proteins / Q000096:biosynthesis*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D051839:NFI Transcription Factors; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D015996:Survival Rate; D014157:Transcription Factors / Q000096:biosynthesis*; D051840:Y-Box-Binding Protein 1
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014408:Biomarkers, Tumor; D022762:CCAAT-Enhancer-Binding Proteins; D051839:NFI Transcription Factors; D014157:Transcription Factors; D051840:Y-Box-Binding Protein 1