title: Twenty-four-hour manometric study of colonic propulsive activity in patients with diarrhea due to inflammatory (ulcerative colitis) and non-inflammatory (irritable bowel syndrome) conditions.
abstract: BACKGROUND
  Little is known concerning colonic motility and almost nothing is known concerning propulsive activity in pathological conditions characterized by diarrhea of both inflammatory and non-inflammatory origin.
  
  
  OBJECTIVE
  The purpose of the present study was to investigate colonic propulsive activity in ulcerative colitis and diarrhea-predominant irritable bowel syndrome (IBS) patients.
  
  
  METHODS
  Seven patients with active, moderate ulcerative colitis and nine diarrhea-predominant IBS patients entered the study. Sixteen healthy volunteers were recruited as a control group. In all subjects, 24-h colonic motility was recorded by a colonoscopically positioned manometric catheter. Both high- (mass movements) and low-amplitude propagated contractions were analyzed.
  
  
  RESULTS
  High-amplitude propagated contractions were significantly increased in ulcerative colitis with respect to controls; no significant differences were found with respect to IBS patients, and between IBS and controls. Concerning amplitude, no significant difference was found between groups, although IBS patients approached the statistical difference with respect to controls. Low-amplitude propagated contractions were significantly increased in ulcerative colitis with respect to controls; no significant differences were found compared with IBS patients. The latter, however, displayed a trend toward an increase with respect to controls that approached but did not reach statistical significance.
  
  
  CONCLUSIONS
  Both inflammatory and non-inflammatory diarrheal conditions are characterized by an overall increase of colonic propulsive activity. This observation may be useful for a better understanding of the pathophysiologic mechanisms of these disorders.
authors.affiliation: Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Perugia, Via Enrico Dal Pozzo, Padiglione W, Perugia, Italy. gabassot@tin.it
authors.forename: Gabrio
authors.initials: G
authors.lastname: Bassotti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: de Roberto
authors.forename: Fabio
authors.initials: F
authors.lastname: Chistolini
authors.forename: Francis
authors.initials: F
authors.lastname: Sietchiping-Nzepa
authors.forename: Olivia
authors.initials: O
authors.lastname: Morelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Morelli
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000150:complications*; D003106:Colon / Q000502:physiology*; D003967:Diarrhea / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D007249:Inflammation; D043183:Irritable Bowel Syndrome / Q000150:complications*; D008297:Male; D008365:Manometry; D008875:Middle Aged