title: [Age-related changes in protein and lipid oxidation in the liver of prematurely aging rats OXYS].
abstract: Age-dependent variations in products of lipid peroxidation products (LPO) and oxidative damage of proteins have been studied in the liver mitochondria and microsomes of premature aging OXYS rats. Characteristics of oxidative processes in OXYS rats were compared with parameters in Wistar rats. Changes in lipid peroxidation products content and oxidative damage of proteins in rat liver mitochondria and microsomes of both strains rats were nonlinear and had opposite direction during the first year of life. The level of protein oxidative damage in OXYS rat liver mitochondria and cytosol was higher than in Wistar at 12 months. The content of primary and end lipid peroxidation products in OXYS rat liver microsomes was significantly decreased in 12 months, but content of conjugated dienes was increased in mitochondria.
authors.affiliation: Institute of Cytology and Genetics, Institute of Physiology, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia. N.G.Kolosova@iph.ma.nsc.ru
authors.forename: N G
authors.initials: NG
authors.lastname: Kolosova
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Grishanova
authors.forename: Zh S
authors.initials: ZhS
authors.lastname: Krysanova
authors.forename: T V
authors.initials: TV
authors.lastname: Zueva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Sidorova
authors.forename: O I
authors.initials: OI
authors.lastname: Sinitsyna
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D005609:Free Radicals / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
chemical_list: D005609:Free Radicals; D011506:Proteins