Isoflavones and women's health.
There is evidence that diets which contain high levels of phytoestrogenic isoflavanoids are associated with a low incidence of osteoporosis and menopausal vasomotor symptoms. Plant extracts such as red clover, which contain high levels of isoflavanoids, have been used to reduce menopausal symptoms and have been shown to reduce bone loss in healthy women. A placebo-controlled clinical trial [ISRCTN42940165] of red clover is reported in this issue of Breast Cancer Research and shows that these phytoestrogens do not cause any oestrogenic increase in breast density, which would indicate that they are unlikely to cause an increased risk of breast cancer.
Powles
Trevor
T
Parkside Hospital, Wimbledon, London. amccabe@parkside-hospital.co.uk
D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001842:Bone and Bones / Q000187:drug effects; D001940:Breast / Q000187:drug effects; D001943:Breast Neoplasms / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects; D019584:Hot Flashes / Q000188:drug therapy; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D008593:Menopause / Q000187:drug effects*; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D048789:Phytoestrogens; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D020845:Selective Estrogen Receptor Modulators / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D013923:Thromboembolism / Q000209:etiology; D029921:Trifolium / Q000737:chemistry
D016588:Anticarcinogenic Agents; D007529:Isoflavones; D048789:Phytoestrogens; D010936:Plant Extracts; D028321:Plant Preparations; D020845:Selective Estrogen Receptor Modulators