[Gln192Arg polymorphism of the paraoxonase-1 gene is not associated with Alzheimer's disease in Chinese].
OBJECTIVE
To explore the relationship between paraoxonase-1 (PON1) gene Gln192Arg polymorphism and sporadic Alzheimer's disease (AD) in Chinese.


METHODS
A total of 165 AD patients and 174 age-matched control subjects were enrolled in this study for examination of PON1 Gln192Arg and apolipoprotein E gene polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
The distribution of PON1 allelic and genotypic frequencies did not significantly differ between AD patients and the control subjects, even after the stratification by ApoE-epsilon4 status.


CONCLUSIONS
Gln192Arg polymorphism of the PON1 gene is not associated with sporadic AD in Chinese.
Shi
Jia-jun
JJ
Department of Medical Genetics and Division of Human Morbid Genomics, Key Laboratory of Biotherapy of Human Diseases of the Ministry of Education, West China Hospital, Sichuan University, Chengdu 610041, China. shiand98@21cn.com
Zhang
Si-zhong
SZ
Ma
Cui
C
Tang
Mou-ni
MN
Liu
Xie-he
XH
Wang
Ying-cheng
YC
Han
Hai-ying
HY
Guo
Yang-bo
YB
Feng
Rong-mei
RM
Miao
Guo-dong
GD
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human