title: Unusual selectivity of unprotected aziridines in palladium-catalyzed allylic amination enables facile preparation of branched aziridines.
abstract: Functionalized branched aziridines can be prepared in high yields and with high levels of regioselectivity using unprotected aziridines as nitrogen sources in palladium-catalyzed allylic amination. High levels of enantioselectivity can be achieved with BINAP on palladium. This methodology allows for strategic placement of an aziridine-containing fragment within a complex molecule environment for further elaboration.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, The University of Toronto, Ontario, Canada.
authors.forename: Iain D G
authors.initials: ID
authors.lastname: Watson
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Styler
authors.forename: Andrei K
authors.initials: AK
authors.lastname: Yudin