title: [The relationship between malignant transformation and fertilization types of hydatidiform moles].
abstract: OBJECTIVE
  To study the relationship between malignant transformation and fertilization types of hydatidiform moles (HM).
  
  
  METHODS
  Fifty four HM specimens were analyzed by using multiplex STR-PCR (9 loci) to determine the fertilization types and all patients were followed-up for the human chorionic gonadotropin (hCG) over 1 year.
  
  
  RESULTS
  Total malignant transformation cases were 10 in all the 54 HM. Ggenetics complete hydatidiform moles (g-CHM) with DNA from only paternal origin, were observed in 38 cases including 28 homozygote and 10 heterozygote cases. In homozygote and heterozygote cases,malignant transformation occurred in 8 cases of the empty eggs fertilized by single sperms and 2 by double sperms respectively. In all the 54 HMs, 16 cases of DNA from parents were genetic partial hydatidiform moles (g-PHM), and no malignant transformation occurred in each haploidy egg fertilized by double sperms.
  
  
  CONCLUSIONS
  (1)Genetic complete hydatidiform moles (g-CHM) showed a higher malignant transformation risk than genetic partial hydatidiform moles (g-PHM) (P=0.024 2); (2)There was no significant difference in malignant transformation between homozygote and heterozygote of g-CHM (P=0.699).
authors.affiliation: Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, China. zhangxw@public.fhnet.cn.net
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Zhang
authors.forename: Hao-bin
authors.initials: HB
authors.lastname: Zhu
authors.forename: Ya-qin
authors.initials: YQ
authors.lastname: Gao
authors.forename: Shu-ying
authors.initials: SY
authors.lastname: Wu
authors.forename: Rong-lian
authors.initials: RL
authors.lastname: Gao
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Han
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Wang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Guo
authors.forename: Yang-yu
authors.initials: YY
authors.lastname: Zhao
authors.forename: Wen-qiu
authors.initials: WQ
authors.lastname: Zhao
mesh_terms: D002471:Cell Transformation, Neoplastic; D005260:Female; D005306:Fertilization; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D020080:Tandem Repeat Sequences; D014594:Uterine Neoplasms / Q000235:genetics* / Q000469:parasitology / Q000503:physiopathology