Development of patient-friendly preparations: preparation of a new allopurinol mouthwash containing polyethylene(oxide) and carrageenan.
Stomatitis is a harmful side effect induced by high and/or multiple dosing of cytotoxic drugs such as 5-fluorouracil. Allopurinol mouthwash has been used to prevent stomatitis induced by cancer chemotherapy. In the present study, the pharmaceutical utility of allopurinol mouthwash (Alkox-mw), which consists of polyethylene(oxide) (Alkox) and iota-carrageenan (INA), was investigated as a possible material for a new oral dosage preparation for improving the adhesiveness onto the oral mucosa. From the observation of the gel formation, which was studied as a function of the variety of the added Alkox and/or INA, the preferential compositions of Alkox-mw (Alkox:INA % ratio) seemed to be 1.0:(0-1.0) and (0-3.0):0.4, respectively. The adhesiveness and the spinnability of various allopurinol mouthwashes were also investigated using a creep meter. The adhesiveness of Alkox-mw increased with the increase in the amount of added Alkox. Furthermore, the adhesion force of Alkox-mw was greater than that of allopurinol mouthwash consisting of sodium carboxymethylcellulose (CMC-Na). From the in vitro assessment of mimicking the effusion of the allopurinol mouthwashes from the surface of the oral mucosa, the effusion of Alkox-mws was retarded by the added Alkox. The results obtained in the present study suggest that Alkox-mws may be useful as a new dosage form that adheres to the oral mucosa.
Hanawa
Takehisa
T
Department of Pharmacy, Yamanashi Medical University, Tamaho, Yamanashi, Japan. thana@res.yamanashi-med.ac.jp
Masuda
Nami
N
Mohri
Kiminori
K
Kawata
Keishi
K
Suzuki
Masahiko
M
Nakajima
Shin'ichiro
S
D000268:Adhesiveness; D000493:Allopurinol / Q000008:administration & dosage / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002351:Carrageenan / Q000737:chemistry*; D004548:Elasticity; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D005782:Gels; D009061:Mouth Mucosa; D009067:Mouthwashes; D011092:Polyethylene Glycols / Q000737:chemistry*; D014783:Viscosity
D004791:Enzyme Inhibitors; D005782:Gels; D009067:Mouthwashes; D011092:Polyethylene Glycols; D000493:Allopurinol; D002351:Carrageenan; D002266:Carboxymethylcellulose Sodium