title: Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders.
abstract: Several lines of evidence suggest that genetic factors might contribute to the pathogenesis of eating disorders and that brain-derived neurotrophic factor (BDNF) plays a role in the pathophysiology of eating disorders. To investigate the role of the BDNF gene in the susceptibility to eating disorders, we analyzed the BDNF 196G/A gene polymorphism in female patients with eating disorders and female normal controls. The difference in the genotype frequency between patients (n = 198) and normal controls (n = 222) was statistically significant (P = 0.029). Interestingly, a significant (P = 0.015) difference in the genotype frequency between normal controls and bulimia nervosa patients (n = 101) with binge-purging type was detected. This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders.
authors.affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Koizumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Kanako
authors.initials: K
authors.lastname: Itoh
authors.forename: Michiko
authors.initials: M
authors.lastname: Nakazato
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
authors.forename: Shintaro
authors.initials: S
authors.lastname: Ohgake
authors.forename: Kaori
authors.initials: K
authors.lastname: Koike
authors.forename: Naoe
authors.initials: N
authors.lastname: Okamura
authors.forename: Sachio
authors.initials: S
authors.lastname: Matsushita
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Murayama
authors.forename: Susumu
authors.initials: S
authors.lastname: Higuchi
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004247:DNA / Q000032:analysis / Q000235:genetics; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004247:DNA