A strategy for exploiting the pseudosymmetry of the C1-C13 stretch of discodermolide.
[reaction: see text] The pseudo-C(2)() symmetry of the C1 to C13 stretch of the discodermolide structure offers a potential strategic advantage for synthetic design. Two approaches based on this recognition were devised, and one was shown to be effective in a model series.
Parker
Kathlyn A
KA
Department of Chemistry, State University of New York at Stony Brook Stony Brook, New York 11794-3400, USA. kparker@notes.cc.sunysb.edu
Katsoulis
Ioannis A
IA
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D011753:Pyrones; D013237:Stereoisomerism
D000473:Alkanes; D002219:Carbamates; D007783:Lactones; D011753:Pyrones; C071229:discodermolide