title: Biaryl amide glucagon receptor antagonists.
abstract: Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.
authors.affiliation: Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. ravi.kurukulasuriya@abbott.com
authors.forename: Ravi
authors.initials: R
authors.lastname: Kurukulasuriya
authors.forename: Bryan K
authors.initials: BK
authors.lastname: Sorensen
authors.forename: James T
authors.initials: JT
authors.lastname: Link
authors.forename: Jyoti R
authors.initials: JR
authors.lastname: Patel
authors.forename: Hwan-Soo
authors.initials: HS
authors.lastname: Jae
authors.forename: Marty X
authors.initials: MX
authors.lastname: Winn
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Rohde
authors.forename: Nelson D
authors.initials: ND
authors.lastname: Grihalde
authors.forename: Chun W
authors.initials: CW
authors.lastname: Lin
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Ogiela
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Adler
authors.forename: Christine A
authors.initials: CA
authors.lastname: Collins
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000882:Haplorhini; D006801:Humans; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D018027:Receptors, Glucagon / Q000037:antagonists & inhibitors*
chemical_list: D000577:Amides; D018027:Receptors, Glucagon