Lipopolysaccharide evoked peptide release by calcium-induced calcium release.
Calcium may play a key role in the lipopolysaccharide (LPS)-induced release of calcitonin gene-related peptide in rat dorsal root ganglion neurons. Both calcium entry via voltage-activated calcium channels sensitive to either omega-conotoxin GVIA or omega-agatoxin IVA, and calcium release from ryanodine-sensitive calcium stores were involved in this process. Cyclic ADP-ribose antagonist affected neither the enhancement of cytoplasmic free calcium nor the release of calcitonin gene-related peptide induced by LPS. These findings underscore a pivotal role of calcium-induced calcium release in lipopolysaccharide-stimulated calcitonin gene-related peptide release from nociceptive neurons.
Qin
Xiaomei
X
Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100083, PR China.
Hou
Lingfei
L
Wang
Xian
X
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051381:Rats
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D008070:Lipopolysaccharides; D015740:Calcitonin Gene-Related Peptide; D002118:Calcium