title: Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections.
abstract: Elderberry has been used in folk medicine for centuries to treat influenza, colds and sinusitis, and has been reported to have antiviral activity against influenza and herpes simplex. We investigated the efficacy and safety of oral elderberry syrup for treating influenza A and B infections. Sixty patients (aged 18-54 years) suffering from influenza-like symptoms for 48 h or less were enrolled in this randomized, double-blind, placebo-controlled study during the influenza season of 1999-2000 in Norway. Patients received 15 ml of elderberry or placebo syrup four times a day for 5 days, and recorded their symptoms using a visual analogue scale. Symptoms were relieved on average 4 days earlier and use of rescue medication was significantly less in those receiving elderberry extract compared with placebo. Elderberry extract seems to offer an efficient, safe and cost-effective treatment for influenza. These findings need to be confirmed in a larger study.
authors.affiliation: Department of Virology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Zakay-Rones
authors.forename: E
authors.initials: E
authors.lastname: Thom
authors.forename: T
authors.initials: T
authors.lastname: Wollan
authors.forename: J
authors.initials: J
authors.lastname: Wadstein
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D009981:Influenza B virus / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D008297:Male; D010919:Placebos; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D027924:Sambucus nigra / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D010936:Plant Extracts