Mapping quantitative traits with random and with ascertained sibships.
Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large.
Peng
Jie
J
Department of Statistics, Stanford University, Stanford, CA 94305, USA.
Siegmund
D
D
D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D040641:Quantitative Trait Loci / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012044:Regression Analysis; D035781:Siblings