title: [Changes in the functional status of the liver in the course of chronic obstructive bronchitis].
abstract: Hypoxia conditioned by chronic pulmonary insufficiency is associated in patients with chronic obstructive bronchitis with a more intense free-radical oxidation. A reduced ventilation of the lungs is concurrent in patients with a higher level of malonic aldehyde, as well as with a lower activity of superoxide dismutase and catalase. The liver is involved into the pathological process as a back-feed mechanism in response to the oxidation shift in tissues. Changes of the blood amine-acid spectrum, disproteimenia and hyper-fermentation observed in patients with chronic obstructive bronchitis (COB) denote the impaired hepatocyte condition. The regulating liver function is displayed through an intensified synthesis of endogenous antioxidants: 1) high-molecular--superoxide dismutase, catalase, ceruloplasmia and albumin; 2) low-molecular--uric acid, thiol compounds, biogenic amines, bilirubin, cholesterol as well as molecules of the bioenergetics cycles. As for the early COB stages, a higher level of antioxidant enzymes is more pronounced, whereas, the low-molecule endogenous antioxidants are in the forefront in the disease later stages.
authors.forename: G E
authors.initials: GE
authors.lastname: Mironova
authors.forename: Z N
authors.initials: ZN
authors.lastname: Krivoshapkina
authors.forename: B T
authors.initials: BT
authors.lastname: Velichkovskiĭ
mesh_terms: D000328:Adult; D000418:Albumins / Q000378:metabolism; D029481:Bronchitis, Chronic / Q000201:enzymology / Q000453:epidemiology / Q000503:physiopathology*; D015897:Comorbidity; D005260:Female; D006529:Hepatomegaly / Q000201:enzymology / Q000453:epidemiology / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D019272:Leukocyte Elastase / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D000418:Albumins; D019272:Leukocyte Elastase