title: Ocular photodynamic therapy in choroidal neovascularization complicating idiopathic central serous chorioretinopathy.
abstract: Two consecutive patients with idiopathic central serous chorioretinopathy and decreased vision subsequent to subfoveal choroidal neovascular membranes were treated with photodynamic therapy applied using the protocol of the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy Study Group. Main outcome measures included best-corrected visual acuity, biomicroscopic appearance, and leakage on fluorescein and indocyanine green angiography. Photodynamic therapy offered anatomical, angiographic, and functional improvement. After an initial complete response, the patients required re-treatment at 3 and 4 months, respectively. Cessation of leakage with improvement in visual acuity occurred, but subretinal fibrosis posed a possible limitation for full functional recovery. Although choroidal neovascular membranes complicating idiopathic central serous chorioretinopathy portend a poor visual prognosis, the overall response to photodynamic therapy was favorable.
authors.affiliation: Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112-2699, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Canakis
authors.forename: Mandi D
authors.initials: MD
authors.lastname: Conway
authors.forename: Charalampos
authors.initials: C
authors.lastname: Livir-Rallatos
authors.forename: Georges J
authors.initials: GJ
authors.lastname: Naaman
authors.forename: Ramakrishna
authors.initials: R
authors.lastname: Ratnakaram
authors.forename: Gamze
authors.initials: G
authors.lastname: Men
authors.forename: Gholam A
authors.initials: GA
authors.lastname: Peyman
mesh_terms: D000328:Adult; D015862:Choroid Diseases / Q000188:drug therapy* / Q000209:etiology; D020256:Choroidal Neovascularization / Q000150:complications / Q000188:drug therapy*; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D012164:Retinal Diseases / Q000188:drug therapy* / Q000209:etiology; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green