HIV-1 Vpu: putting a channel to the TASK.
Vpu is an HIV-encoded protein that enhances virus release. Previously, this activity was correlated with an intrinsic ion channel activity of Vpu. In this issue of Molecular Cell, Hsu at all. propose an alternative mechanism: they suggest that Vpu functions by inhibiting another ion channel, TASK-1.
Strebel
Klaus
K
Laboratory of Molecular Microbiology, National Institute for Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, MSC 0460, Bethesda, MD 20892, USA.
D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D015497:HIV-1 / Q000378:metabolism* / Q000648:ultrastructure; D054298:Human Immunodeficiency Virus Proteins; D006801:Humans; D008954:Models, Biological; D009419:Nerve Tissue Proteins; D015221:Potassium Channels / Q000378:metabolism*; D024683:Potassium Channels, Tandem Pore Domain; D014764:Viral Proteins / Q000378:metabolism*; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics / Q000378:metabolism*; D014771:Virion / Q000378:metabolism; D000086082:Viroporin Proteins
D054298:Human Immunodeficiency Virus Proteins; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins; C420132:potassium channel subfamily K member 3