title: Botox and collagen for glabellar furrows: advantages of combination therapy.
abstract: Plastic surgeons frequently administer botulinum toxin A (Botox) or collagen as monotherapy to treat glabellar furrows. This study evaluates the possible advantages of combination therapy. Sixty-five patients with moderate to severe glabellar rhytids were prospectively randomized to receive standard injections of Botox, Zyderm II collagen, or a combination. Improvement in rhytids was assessed over 3 months using patient satisfaction scores and an independent physician evaluation. Baseline wrinkle severity was similar in all 3 groups. By 1 month posttreatment, the combination arm showed significantly greater improvement in furrows (79% compared with only 56% and 50% in the Botox and Zyderm arms, respectively; P < 0.05). At 3 months postinjection, the dual-therapy arm maintained better improvement (57% versus 33% and 27% in the monotherapy arms; P < 0.05). Patient satisfaction further highlighted the superiority of the combination approach. By simultaneously addressing the static and dynamic aspects of glabellar furrows, dual therapy provides optimal treatment of this problem.
authors.affiliation: Division of Plastic Surgery at New York Presbyterian Hospital-Cornell Medical Center, New York, NY 10021, USA.
authors.forename: Munjal P
authors.initials: MP
authors.lastname: Patel
authors.forename: Mia
authors.initials: M
authors.lastname: Talmor
authors.forename: William B
authors.initials: WB
authors.lastname: Nolan
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D005546:Forehead; D006801:Humans; D007271:Injections, Intradermal; D008297:Male; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D003879:Dermatologic Agents; D009465:Neuromuscular Agents; D003094:Collagen; D019274:Botulinum Toxins, Type A