Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.
Keith
Kathy A
KA
University of Alabama School of Medicine, Birmingham, Alabama 35233, USA.
Wan
William B
WB
Ciesla
Stephanie L
SL
Beadle
James R
JR
Hostetler
Karl Y
KY
Kern
Earl R
ER
D000478:Alkylation; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077404:Cidofovir; D015608:Cowpox virus / Q000187:drug effects; D003500:Cyclization; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D018155:Orthopoxvirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir