title: Meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature.
abstract: The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy.
authors.affiliation: Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, Korea.
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Bae
authors.forename: Hun Mo
authors.initials: HM
authors.lastname: Ryoo
authors.forename: Hee Soon
authors.initials: HS
authors.lastname: Cho
authors.forename: Jae Lyun
authors.initials: JL
authors.lastname: Lee
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Hyun
mesh_terms: D000328:Adult; D042381:Granulocyte Precursor Cells; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D008297:Male; D008578:Meninges; D012008:Recurrence