title: [Ultrafast opiate detoxification under general anesthesia: the St. Loup Hospital experience].
abstract: Rapid antagonist induction under anesthesia is a method that has been increasingly used to detoxify opiate addicts. These procedures are useful to reduce the duration and the discomfort of withdrawal. However, the high risk and the cost of these methods require randomized clinical trial to evaluate safety and clinical effectiveness. The University Substance Abuse Division of Lausanne and the Intensive Care Unit of the St-Loup Hospital work on a randomized clinical trial comparing anesthesia-assisted versus traditional clonidine detoxification combined with an additional psychosocial week. This paper describes the technique of anesthesia used in our study. Our clinical experience suggests that, integrating this technique in a multidisciplinary network, with a strong emphasis on post-anesthetic follow-up, is a viable and safe option in the treatment of opiate dependence.
authors.affiliation: Division d'Abus de Substances Département Universitaire de Psychiatrie Adulte Clinique de Cery 1008 Prilly-Lausanne. Gregoire.Zimmermann@ip.unil.ch
authors.forename: Grégoire
authors.initials: G
authors.lastname: Zimmermann
authors.forename: Bernard
authors.initials: B
authors.lastname: Favrat
authors.forename: Jacques
authors.initials: J
authors.lastname: Muller
authors.forename: Daniele
authors.initials: D
authors.lastname: Zullino
authors.forename: Sonia
authors.initials: S
authors.lastname: Krenz
authors.forename: Eliane
authors.initials: E
authors.lastname: Deyras
authors.forename: Frédéric
authors.initials: F
authors.lastname: Dorogi
authors.forename: André
authors.initials: A
authors.lastname: Zwahlen
authors.forename: Jacques
authors.initials: J
authors.lastname: Besson
mesh_terms: D000293:Adolescent; D000768:Anesthesia, General / Q000379:methods*; D006801:Humans; D009293:Opioid-Related Disorders / Q000628:therapy*; D018579:Patient Selection; D012307:Risk Factors; D013557:Switzerland