[Anti-arrhythmia activity of derinat in an experiment].
The acute toxicity of the immunostimulant derinat is very low: the LD50 value for intraperitoneal administration exceeds 1000 mg/kg. The drug effectively prevents from acute arrhythmia development upon occlusion in cats and produces antifibrillator effect on a model of reperfusive arrhythmia in a dose of 7.5 mg/kg. Derinat also exhibits the antiarrhythmic activity on the model of adrenalin-induced rhythm violations, but appears ineffective on the calcium chloride model.
Sviatkina
O I
OI
Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Balashov
V P
VP
Balykova
L A
LA
Shchukin
S A
SA
D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D004247:DNA / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051381:Rats
D000276:Adjuvants, Immunologic; D000889:Anti-Arrhythmia Agents; D004247:DNA