[Changes in the microsomal monooxygenase system of the rat liver in acute pancreatitis and during induction by Aroclor 1254].
The effect of Arochlor 1254 treatment of rats on activities of cytochrome P450 isoforms 1A1, 1A2, 2C6 was investigated under conditions of acute pancreatitis. Irrespectively to the scheme of Arochlor 1254 administration (before the development of pancreatitis, and at various periods after its provocation) cytochrome P450 activities were higher than in corresponding controls.
Prokop'eva
N V
NV
Institute of Molecular Biology and Biophysics, Siberian Branch of Russian Academy of Medical Sciences, Timakova 2, Novosibirsk, 630117 Russia.
Guliaeva
L F
LF
Poliakova
N E
NE
D000208:Acute Disease; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis / Q000378:metabolism*; D020111:Chlorodiphenyl (54% Chlorine) / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism; D004790:Enzyme Induction; D007527:Isoenzymes / Q000096:biosynthesis / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010195:Pancreatitis / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
D007527:Isoenzymes; D020111:Chlorodiphenyl (54% Chlorine); D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases