title: Expression of beta-catenin in developing auditory epithelia of mice.
abstract: This study investigated the role of beta-catenin in the development of mouse auditory epithelia. Inner ears obtained from embryonic and newborn mice were used. Expression of beta-catenin was examined together with the expression of Ki-67, a marker for proliferating cells, or myosin VIIa, a marker for differentiated hair cells. In the early phase of development, intense expression of beta-catenin was found in auditory epithelia in which a number of Ki-67-positive cells were identified. Together with a decrease in proliferating cells, the intensity and area of beta-catenin expression were reduced. In addition, during differentiation and maturation of hair cells, the area of beta-catenin expression was further limited. These findings suggest that patterns of expression of beta-catenin are closely linked with the status of auditory epithelia development.
authors.affiliation: Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Takebayashi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Ken
authors.initials: K
authors.lastname: Kojima
authors.forename: Tae-Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kita
authors.forename: Youyi
authors.initials: Y
authors.lastname: Dong
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Endo
authors.forename: Fukuichiro
authors.initials: F
authors.lastname: Iguchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Naito
authors.forename: Koichi
authors.initials: K
authors.lastname: Omori
authors.forename: Juichi
authors.initials: J
authors.lastname: Ito
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003051:Cochlea / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism* / Q000502:physiology; D004398:Dyneins; D005314:Embryonic and Fetal Development; D004848:Epithelium / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D005260:Female; D006198:Hair Cells, Auditory / Q000254:growth & development; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D000081412:Myosin VIIa; D009218:Myosins / Q000378:metabolism; D011247:Pregnancy; D015534:Trans-Activators / Q000378:metabolism* / Q000502:physiology; D051176:beta Catenin
chemical_list: C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D019394:Ki-67 Antigen; C000631456:Myo7a protein, mouse; D000081412:Myosin VIIa; D015534:Trans-Activators; D051176:beta Catenin; D009218:Myosins; D004398:Dyneins