title: Prediction of gestational hypertension or intrauterine fetal growth restriction by mid-trimester 24-h ambulatory blood pressure monitoring.
abstract: OBJECTIVE
  To investigate clinical impact of 24-h ambulatory blood pressure monitoring (ABPM) on the prediction of hypertensive disorders of pregnancy and IUGR.
  
  
  METHODS
  ABPM was performed in 334 normotensive non-proteinuric nulliparous women at 20 weeks' gestation. Arterial blood pressure patterns were analyzed by chronobiometry.
  
  
  RESULTS
  Women who developed idiopathic IUGR (21) or PIH (33) showed a 24-h diastolic blood pressure mean significantly higher than the controls (69.2+/-1.8 mmHg and 73.5+/-6.2 vs. 62.2+/-1.5). Women with subsequent IUGR also showed a modification in BP rhythm. The most effective cut-off levels of 24-h diastolic blood pressure mean proved to be 67 for IUGR and 68 for hypertension.
  
  
  CONCLUSIONS
  ABPM in the second trimester reliably predicts idiopathic IUGR and PIH. Both patients destined to develop gestational hypertension and those destined to develop IUGR show similar elevations in 24-h diastolic mean at 20 weeks' gestation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Ancona, Ancona, Italy. tranquilli@univpm.it
authors.forename: A L
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: S R
authors.initials: SR
authors.lastname: Giannubilo
authors.forename: B
authors.initials: B
authors.lastname: Dell'Uomo
authors.forename: A
authors.initials: A
authors.lastname: Corradetti
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis*; D008137:Longitudinal Studies; D011237:Predictive Value of Tests; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis*; D011262:Pregnancy Trimester, Second / Q000502:physiology; D012680:Sensitivity and Specificity