title: BioBuilder as a database development and functional annotation platform for proteins.
abstract: BACKGROUND
  The explosion in biological information creates the need for databases that are easy to develop, easy to maintain and can be easily manipulated by annotators who are most likely to be biologists. However, deployment of scalable and extensible databases is not an easy task and generally requires substantial expertise in database development.
  
  
  RESULTS
  BioBuilder is a Zope-based software tool that was developed to facilitate intuitive creation of protein databases. Protein data can be entered and annotated through web forms along with the flexibility to add customized annotation features to protein entries. A built-in review system permits a global team of scientists to coordinate their annotation efforts. We have already used BioBuilder to develop Human Protein Reference Database http://www.hprd.org, a comprehensive annotated repository of the human proteome. The data can be exported in the extensible markup language (XML) format, which is rapidly becoming as the standard format for data exchange.
  
  
  CONCLUSIONS
  As the proteomic data for several organisms begins to accumulate, BioBuilder will prove to be an invaluable platform for functional annotation and development of customizable protein centric databases. BioBuilder is open source and is available under the terms of LGPL.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine and the Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. dnavarro@jhmi.edu
authors.forename: J Daniel
authors.initials: JD
authors.lastname: Navarro
authors.forename: Naveen
authors.initials: N
authors.lastname: Talreja
authors.forename: Suraj
authors.initials: S
authors.lastname: Peri
authors.forename: B M
authors.initials: BM
authors.lastname: Vrushabendra
authors.forename: B P
authors.initials: BP
authors.lastname: Rashmi
authors.forename: N
authors.initials: N
authors.lastname: Padma
authors.forename: Vineeth
authors.initials: V
authors.lastname: Surendranath
authors.forename: Chandra Kiran
authors.initials: CK
authors.lastname: Jonnalagadda
authors.forename: P S
authors.initials: PS
authors.lastname: Kousthub
authors.forename: Nandan
authors.initials: N
authors.lastname: Deshpande
authors.forename: K
authors.initials: K
authors.lastname: Shanker
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
mesh_terms: D019295:Computational Biology / Q000379:methods / Q000592:standards; D003628:Database Management Systems; D030562:Databases, Protein / Q000592:standards; D006801:Humans; D020407:Internet; D011506:Proteins / Q000502:physiology* / Q000592:standards; D012984:Software / Q000592:standards; D012985:Software Design
chemical_list: D011506:Proteins