title: Linezolid-induced bradycardia: a case report.
abstract: We report an episode of severe bradycardia that occurred in a 49-year-old woman with fever and malignant jaundice during antibiotic therapy with linezolid, a new oxazolidinone with activity against Gram-positive cocci. In our case, the strict temporal dependence between bradycardia and linezolid therapy seems to provide strong evidence for a causal relationship. To our knowledge, this is the first report of linezolid-induced bradycardia. This adverse event confirms that the new antibiotic linezolid should be administered with caution in patient with jaundice and hepatic insufficiency.
authors.affiliation: Division of Medical Oncology and Haematology, Centro di Riferimento Oncologico della Basilicata, Strada Provinciale No. 8, 85028 Rionero in Vulture (PZ), Italy. tarta1@virgilio.it
authors.forename: Alfredo
authors.initials: A
authors.lastname: Tartarone
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Gallucci
authors.forename: Giovanni
authors.initials: G
authors.lastname: Iodice
authors.forename: Giampiero
authors.initials: G
authors.lastname: Romano
authors.forename: Mariarosa
authors.initials: M
authors.lastname: Coccaro
authors.forename: Maria Luigia
authors.initials: ML
authors.lastname: Vigliotti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mele
authors.forename: Rosella
authors.initials: R
authors.lastname: Matera
authors.forename: Nicola
authors.initials: N
authors.lastname: Di Renzo
mesh_terms: D000081:Acetamides / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000009:adverse effects*; D001919:Bradycardia / Q000139:chemically induced*; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000188:drug therapy; D006801:Humans; D007565:Jaundice / Q000150:complications / Q000188:drug therapy; D000069349:Linezolid; D008875:Middle Aged; D023303:Oxazolidinones / Q000009:adverse effects*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid