Predictive value of nalidixic acid resistance for detecting salmonellae with decreased ciprofloxacin susceptibility.
Seventy-three Salmonella isolates classified as ciprofloxacin susceptible when using the criteria of the National Committee for Clinical Laboratory Standards were studied for nalidixic acid (NA) resistance. The aim of the study was to determine the predictive value of nalidixic acid resistance in screening for decreased ciprofloxacin susceptibility. We observed that isolates with decreased ciprofloxacin susceptibility were all resistant to nalidixic acid. Identification of nalidixic acid resistance by the disk diffusion method provided 100% sensitivity and a specificity of 98.4% in strains with minimum inhibitory concentrations (MICs) >0.008 mg/l.
Albayrak
F
F
Ankara University Medical Faculty Clinical Bacteriology and Infectious Diseases Department, Ilkadim Mahallesi Seçkin Sokak No. 18/4, 06450 Dikmen, Ankara, Turkey. albayrak@medicine.ankara.edu.tr
Cokca
F
F
Erdem
B
B
Aysev
A D
AD
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*; D011237:Predictive Value of Tests; D012475:Salmonella / Q000145:classification / Q000187:drug effects*; D012480:Salmonella Infections / Q000382:microbiology; D012680:Sensitivity and Specificity; D012703:Serotyping
D000890:Anti-Infective Agents; D009268:Nalidixic Acid; D002939:Ciprofloxacin