title: Annular elastolytic giant cell granuloma causes an irreversible disappearance of the elastic fibres.
abstract: A 67-year-old man presented with grouped red papules with a smooth surface coalescing to relatively well-demarcated plaques on his left thigh, in the axillae and on the lateral parts of the trunk. The plaques were growing slowly, and the older ones had a frilled surface. A skin biopsy showed a zone of disappearance of the elastic fibres with a rim of giant multinuclear cells with fragments of the elastic fibres in their cytoplasm. This finding is typical of annular elastolytic giant cell granuloma (AEGCG). After corticosteroid therapy, the inflammation resolved, causing the frilled surface of the lesions due to the disappearance of the elastic fibres. Remission of the skin lesions lasted for 1.5 years. A second skin biopsy taken from the site of the previous lesion showed the absence of the elastic fibres, thus their phagocytosis was irreversible.
authors.affiliation: Dermatohistopathologic laboratory and Dermatovenereology clinic, 2nd Medical School of Charles University and University Hospital Motol, Mazurska 484, Prague 8, Czech Republic. lumir.pock@volny.cz
authors.forename: L
authors.initials: L
authors.lastname: Pock
authors.forename: J
authors.initials: J
authors.lastname: Blazková
authors.forename: H
authors.initials: H
authors.lastname: Caloudová
authors.forename: I
authors.initials: I
authors.lastname: Varjassyová
authors.forename: R
authors.initials: R
authors.lastname: Konkolová
authors.forename: J
authors.initials: J
authors.lastname: Hercogová
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D004547:Elastic Tissue / Q000473:pathology; D016460:Granuloma Annulare / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009335:Necrobiosis Lipoidica / Q000473:pathology; D010587:Phagocytosis; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index