title: Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus.
abstract: The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.
authors.affiliation: Department of Pharmacotherapeutics, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. mkimura@jikei.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Kimura
authors.forename: Naoto
authors.initials: N
authors.lastname: Tateishi
authors.forename: Tomoei
authors.initials: T
authors.lastname: Shiota
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshie
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamauchi
authors.forename: Masato
authors.initials: M
authors.lastname: Suzuki
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Shibasaki
mesh_terms: D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood*; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface / Q000235:genetics*; D054411:Receptors, Leptin; D013995:Time
chemical_list: D020738:Leptin; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose; D005947:Glucose