title: Reversible bilateral internuclear ophthalmoplegia associated with FK506.
abstract: A 50 year old man developed tonic-clonic seizures while receiving cyclosporin A after orthotopic cardiac transplant. The seizures resolved after cessation of cyclosporin A. Thirteen months later, he developed diplopia from bilateral internuclear ophthalmoplegia while receiving intravenous FK506. A temporal association was found between his symptoms and the serum FK506 concentrations. Withdrawal of the intravenous FK506 led to prompt resolution of the bilateral internuclear ophthalmoplegia.
authors.affiliation: Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Lai
authors.forename: J B
authors.initials: JB
authors.lastname: Kerrison
authors.forename: N R
authors.initials: NR
authors.lastname: Miller
mesh_terms: D006084:Graft Rejection / Q000188:drug therapy; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000139:chemically induced* / Q000175:diagnosis; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus