[The role of hsp60 and hsp70 kDa heat shock protein families in different types of diabetes mellitus].
The role of stress proteins in the different forms of diabetes has not been elucidated yet, but the most recent data suggest their important role in the development both of the diabetic metabolic disturbances and complications. In type 1 diabetes, where the beta-cells are destroyed by autoimmune processes, the 60 kDa heat shock proteins are among the beta-cell specific antigens, and one of its analogs (DiaPep277) has already been used with success in human studies for immunization. Studies done in type-2 diabetic patients proved that the expression of the 72 kDa heat shock protein in the skeletal muscle highly correlates with the metabolic status of the diabetic patients. Diabetic patients with an order of magnitude less expression of 72 kDa heat shock gene have lower insulin stimulated glucose uptake,--storage and--oxidation and the lipid oxidation is less sensitive to the insulin effect. Both the expression of the 72 kDa heat shock gene and the insulin stimulated glucose uptake are lower in twins with type-2 diabetes even before the manifestation of the disease suggesting the pathological role of this gene. The 72 kDa heat shock protein gene in the circulating mononuclear blood cells of type-2 diabetics can not be stimulated by heat stress, and the magnitude of this heat stress answer negatively correlates with the rate of urinary albumin excretion. These data suggest that the stimulation of heat shock protein genes may improve insulin resistance and this may mean a new intervention area of pharmacology.
Korányi
László
L
Paulus Publishing Bt. Budapest. laszlo.koranyi@drc.hu
Hegedüs
Erzsébet
E
Péterfal
Eva
E
Kurucz
István
I
D001786:Blood Glucose / Q000378:metabolism; D018834:Chaperonin 60 / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance
D001786:Blood Glucose; D018834:Chaperonin 60; D018840:HSP70 Heat-Shock Proteins