title: Inhibition of restenosis in stented porcine coronary arteries: uptake of Paclitaxel from angiographic contrast media.
abstract: OBJECTIVE
  Paclitaxel added to angiographic contrast medium (CM) has been shown to inhibit restenosis in the porcine coronary overstretch model. This study determined early local tissue concentrations after the administration of different paclitaxel doses and preparations.
  
  
  METHODS
  Fifteen pigs received 2 stents each in the left coronary artery. During and/or after the intervention, paclitaxel-containing CM or diluted Taxol was injected. Fifteen minutes after the last intracoronary injection, paclitaxel concentrations in the arterial wall and myocardium were measured by high-performance liquid chromatography.
  
  
  RESULTS
  Mean paclitaxel concentrations in the left coronary arteries reached 3-10 microM. Higher volumes and higher paclitaxel concentrations resulted in higher tissue concentrations. Paclitaxel in CM was better tolerated and led to higher local concentrations than diluted Taxol. Low paclitaxel concentrations in the uninjected right coronary artery and in plasma indicate selectivity.
  
  
  CONCLUSIONS
  When admixed to CM, paclitaxel results in local tissue concentrations proportional to the amount of the drug injected.
authors.affiliation: Department of Radiology, Charité, Humboldt University, Berlin, Germany. ulrich.speck@charite.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Speck
authors.forename: Bruno
authors.initials: B
authors.lastname: Scheller
authors.forename: Claudia
authors.initials: C
authors.lastname: Abramjuk
authors.forename: Stephan
authors.initials: S
authors.lastname: Grossmann
authors.forename: Dirk
authors.initials: D
authors.lastname: Mahnkopf
authors.forename: Oliver
authors.initials: O
authors.lastname: Simon
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D003287:Contrast Media / Q000008:administration & dosage*; D017023:Coronary Angiography / Q000379:methods*; D023903:Coronary Restenosis / Q000517:prevention & control*; D003331:Coronary Vessels / Q000737:chemistry / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000379:methods; D004359:Drug Therapy, Combination; D017239:Paclitaxel / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics; D015607:Stents; D013552:Swine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003287:Contrast Media; D017239:Paclitaxel