Cytotoxic activity of endometrial immunocompetent cells determines the outcome of embryo implantation.
The data on the formation of blastocysts in culture during therapeutic cycles of extracorporeal fertilization and on cytotoxic index of the endometrium in women with different clinical pathogenetic variants of sterility are presented. Analysis of correlations of these parameters with the incidence of effective implantation and pregnancy revealed a strict correlation between cytotoxic activity of endometrial immunocompetent cells and human embryo implantation.
Yamanova
M V
MV
Krasnoyarsk State Medical Academy, St. Petersburg. ivf@scn.ru
Salmina
A B
AB
Svetlakov
A V
AV
Ellinidi
V N
VN
Anikeeva
N V
NV
Serebrennikova
O A
OA
Evdochenko
I I
II
D000328:Adult; D001755:Blastocyst / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D010064:Embryo Implantation / Q000276:immunology*; D004624:Embryo Transfer; D004717:Endometrium / Q000166:cytology / Q000276:immunology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007121:Immunocompetence; D011247:Pregnancy; D011256:Pregnancy Outcome; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology