title: Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe.
abstract: The leaf oil of Heteropyxis dehniae Suess. (Heteropyxidaceae) was obtained by hydrodistillation and analyzed by GC/MS. The most abundant essential oil components are linalool (58.3%), 4-terpineol (9.8%), alpha-terpineol (3.6%), and caryophyllene oxide (3.1%). The antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger, and the in vitro cytotoxicity of the oil on PC-3, MDA-MB-231, Hs 578T, MCF7, SK-MEL-28, and 5637 human tumor cells were also examined. Caryophyllene oxide shows notable cytotoxic activity with LC50 values of 147-351 microM.
authors.affiliation: Department of Chemistry, University of Zimbabwe, Box MP 167, Harare, Zimbabwe.
authors.forename: Samson
authors.initials: S
authors.lastname: Sibanda
authors.forename: Grace
authors.initials: G
authors.lastname: Chigwada
authors.forename: Melvin
authors.initials: M
authors.lastname: Poole
authors.forename: Ephraim T
authors.initials: ET
authors.lastname: Gwebu
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Noletto
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Schmidt
authors.forename: Angela I
authors.initials: AI
authors.lastname: Rea
authors.forename: William N
authors.initials: WN
authors.lastname: Setzer
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001234:Aspergillus niger / Q000187:drug effects; D001409:Bacillus cereus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D016488:Medicine, African Traditional; D008826:Microbial Sensitivity Tests; D027822:Myrtaceae; D008517:Phytotherapy; D018515:Plant Leaves; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D015030:Zimbabwe
chemical_list: D000890:Anti-Infective Agents; D010938:Plant Oils