title: Aspirin intolerance and allergy to house dust mites: important factors associated with development of severe asthma.
abstract: BACKGROUND
  Although the occurrence of bronchial asthma is still increasing, the possible factors associated with the development of severe asthma have not been completely determined.
  
  
  OBJECTIVE
  To measure the incidence of severe asthma and its determinants in outpatients. Aspirin intolerance, house dust mite (HDM) allergy, male sex, age older than 65 years, and duration of asthma exceeding 10 years were investigated as factors potentially related to the severity of asthma.
  
  
  METHODS
  The study population included 598 women and 408 men, mean age of 44.59 years (SD +/- 16.45 years), randomly chosen from patients with asthma under follow-up surveillance in an outpatient clinic. Their medical histories were reviewed; spirometry and skin prick tests were performed.
  
  
  RESULTS
  The asthma was diagnosed as intermittent in 35.39%, persistently mild in 33.40%, moderate in 23.76%, and severe in 7.45% of the study cohort. In the patients with atopy, HDM allergy was a significant factor associated with the development of severe asthma [odds ratio (OR) = 5.65]. Of the 1,006 patients, 341 (33.90%) had had asthma for at least 10 years, which was a significant factor in the overall study group (OR = 3.64). We found 95 cases (9.44% of the study group) of aspirin intolerance, including 23 of the 75 patients with severe asthma (30.67%; OR = 5.44). Logistic regression analysis showed that aspirin intolerance was most closely associated with severe asthma (beta = 5.79; P < .001).
  
  
  CONCLUSIONS
  The data from this study show that aspirin intolerance, HDM allergy, and asthma duration exceeding 10 years are major factors associated with severe asthma in outpatients.
authors.affiliation: Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland. matiska@wp.pl
authors.forename: Maciej
authors.initials: M
authors.lastname: Kupczyk
authors.forename: Izabela
authors.initials: I
authors.lastname: Kupryś
authors.forename: Paweł
authors.initials: P
authors.lastname: Górski
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuna
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000485:Allergens / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000453:epidemiology / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011044:Poland; D039981:Pyroglyphidae / Q000276:immunology*; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012737:Sex Factors; D012882:Skin Tests; D013223:Statistics as Topic
chemical_list: D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin