title: Add-on gabapentin in the treatment of opiate withdrawal.
abstract: Gabapentin is an antiepileptic drug shown to be effective in the treatment of pain disorders and appears to be useful as well for several psychiatric disorders, including bipolar disorder, anxiety disorders, alcohol withdrawal and cocaine dependence. Gabapentin, at a dose of 600 mg three times a day, was evaluated as an add-on medication to a standard detoxification regime in seven heroin dependent individuals undergoing outpatient opiate withdrawal treatment. All seven patients successfully completed opiate detoxification and commenced opiate antagonist treatment with naltrexone on day five of withdrawal treatment, as scheduled. No adverse event was noted. Gabapentin appeared to lead a reduction in symptomatic medication and an overall beneficial effect on symptoms of heroin withdrawal.
authors.affiliation: Unidad de Conductas Adictivas del Area 9 de Salud Valencia, Consellería de Sanitat, and Universidad Cardenal Herrera-CEU, Generalitat Valenciana, Spain. martinez_josrag@gva.es
authors.forename: José
authors.initials: J
authors.lastname: Martínez-Raga
authors.forename: Ana
authors.initials: A
authors.lastname: Sabater
authors.forename: Bartolome
authors.initials: B
authors.lastname: Perez-Galvez
authors.forename: Miguel
authors.initials: M
authors.lastname: Castellano
authors.forename: Gaspar
authors.initials: G
authors.lastname: Cervera
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000328:Adult; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D000077206:Gabapentin; D003932:Heroin / Q000009:adverse effects*; D006556:Heroin Dependence / Q000534:rehabilitation; D006801:Humans; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D009294:Narcotics / Q000009:adverse effects*; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D009292:Narcotic Antagonists; D009294:Narcotics; D005680:gamma-Aminobutyric Acid; D009271:Naltrexone; D000077206:Gabapentin; D003932:Heroin