Novel routes to chiral 2-alkoxy-5-/6- methoxycarbonylmethylidenepyrrolidines/-piperidines.
We report the results of a study aimed at the diastereoselective synthesis of chiral 2-alkoxy-5-/6-methoxycarbonylmethylidenepyrrolidines/-piperidines by condensation of chiral amines onto omega-oxo alkynoates and omega-oxo beta-keto esters.
David
Olivier
O
Université P. et M. Curie, Chimie des Hétérocycles, UMR 7611, 4 Place Jussieu, 75252 Paris Cedex 05, France.
Calvet
Sandrine
S
Chau
François
F
Vanucci-Bacqué
Corinne
C
Fargeau-Bellassoued
Marie-Claude
MC
Lhommet
Gérard
G