Short-term immunosuppressive therapy does not affect the density of the pre-existing bone around titanium implants placed in rabbits.
The aim of this study was to evaluate the influence of the administration and withdrawal of cyclosporin A/nifedipine on the bone density in a lateral area adjacent to implants placed in rabbits. Two screw-type titanium implants were placed bilaterally in twenty-eight New Zealand rabbits. The animals were assigned to one of the following groups and received daily subcutaneous injections for 14 days: Groups A and C: vehicle (dimethyl sulfoxide); Groups B and D: CsA (10 mg/kg) plus nifedipine (50 mg/kg). The animals in Groups A and B were sacrificed 14 days postoperatively and, in Groups C and D, 42 days postoperatively. After sacrifice, the tibiae were removed and undecalcified sections were obtained. Bone density was obtained in a 500 mm-wide zone lateral to the implant surface. Intergroup analysis showed no significant difference (p > 0.05) in the degree of bone density between control and test groups either on day 14 or on day 42. Thus, it appears that a short-term immunosuppressive therapy may not present a negative influence on the density of the pre-existing bone around titanium implants placed in rabbits.
Duarte
Poliana Mendes
PM
Department of Prosthodontics and Periodontics, School of Dentistry of Piracicaba, State University of Campinas.
Nogueira Filho
Getúlio Rocha
GR
Sallum
Enilson Antônio
EA
Sallum
Antonio Wilson
AW
Nociti Júnior
Francisco Humberto
FH
D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004338:Drug Combinations; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D020007:Implants, Experimental; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage; D016348:Osseointegration / Q000502:physiology; D011817:Rabbits; D018709:Statistics, Nonparametric; D013977:Tibia; D014025:Titanium / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D015921:Dental Implants; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D014025:Titanium; D009543:Nifedipine