Effects of rubral microinjections of muscimol and bicuculline in a genetic animal model of paroxysmal dystonia.
Previous studies suggested that GABAergic dysfunctions within the red nucleus are involved in stress-inducible paroxysmal dystonia of the dt(sz) mutant hamster. In the present study, rubral microinjections of the GABAA receptor agonist muscimol exerted only moderate antidystonic effects and the antagonist bicuculline failed to show significant effects on the severity of dystonia. These data indicate that disturbed rubral GABAergic inhibition is not important for the manifestation of dystonia in the dt(sz) mutant.
Hamann
Melanie
M
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstrabetae 20, 14195 Berlin, Germany. mhamann@zedat.fu-berlin.de
Richter
Angelika
A
D000818:Animals; D001640:Bicuculline / Q000627:therapeutic use*; D006224:Cricetinae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000188:drug therapy* / Q000235:genetics; D018755:GABA Agonists / Q000627:therapeutic use*; D018756:GABA Antagonists / Q000627:therapeutic use*; D008845:Microinjections; D008957:Models, Genetic; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000627:therapeutic use*; D011930:Reaction Time / Q000187:drug effects; D012012:Red Nucleus / Q000187:drug effects; D013997:Time Factors
D018755:GABA Agonists; D018756:GABA Antagonists; D009118:Muscimol; D001640:Bicuculline