[Lymphoid structure of the spleen after polyoxydonium administration].
The dynamics of structural changes and cellular composition of lymphoid tissue was studied in the spleen of 25 female mice aged 3 months 4-30 days after administration of polyoxydonium--an immunomodulatory drug of a new generation (120 g per animal injected intraperitoneally daily for 3 days). Polyoxydonium was found to possess an immunomodulatory action that was manifested at morphological level by an increase in the number of lymphoid nodules with germinal centers as compared to that one in 25 control mice. Within the germinal centers the absolute numbers of all the types of lymphocytes was increased peaking at day 14 after the polyoxydonium administration, when the number of lymphoblast cells and macrophages reached the maximum value. By day 30 all the parameters of splenic white pulp returned to their levels in control group.
Sharshembiev
Zh A
ZhA
Laboratory of Functional Anatomy, RAMS Institute of Morphology, Moscow.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005260:Female; D018858:Germinal Center / Q000166:cytology / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008815:Mice, Inbred Strains; D009930:Organic Chemicals; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D009930:Organic Chemicals; C089921:polyoxydonium