The aldol reaction of silyl enol ethers within a micro reactor.
We have demonstrated the use of silyl enol ethers in the aldol reaction within a micro reactor. Quantitative conversion of the silyl enol ether to a beta-hydroxyketone was observed in a 20 min period compared to traditional batch systems, where quantitative yields were only obtained when extended reaction times of 24 h were employed.
Wiles
C
C
Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
Watts
P
P
Haswell
S J
SJ
Pombo-Villar
E
E