Virulence of metallo-beta-lactamase-producing Pseudomonas aeruginosa in vitro and in vivo.
We evaluated the virulence of Pseudomonas aeruginosa carrying bla(IMP), a metallo-beta-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia model. The presence of bla(IMP) did not practically change the virulence of the parent strain, and ciprofloxacin was effective against infection with P. aeruginosa carrying bla(IMP).
Aoki
S
S
Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan.
Hirakata
Y
Y
Kondoh
A
A
Gotoh
N
N
Yanagihara
K
K
Miyazaki
Y
Y
Tomono
K
K
Yamada
Y
Y
Kohno
S
S
Kamihira
S
S
D000818:Animals; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D002442:Ceftazidime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use; D015377:Cilastatin / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015378:Imipenem / Q000627:therapeutic use; D007970:Leukopenia / Q000150:complications / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011480:Protease Inhibitors / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D013234:Stem Cells; D013845:Thienamycins / Q000627:therapeutic use; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D011480:Protease Inhibitors; D013845:Thienamycins; D015377:Cilastatin; D002939:Ciprofloxacin; D015378:Imipenem; D002442:Ceftazidime; D001618:beta-Lactamases