IMGT-ONTOLOGY for immunogenetics and immunoinformatics.
IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d'ImmunoGenetique Moleculaire LIGM. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT consists of several sequence databases (IMGT/LIGM-DB, IMGT/MHC-DB, IMGT/PRIMER-DB), one genome database (IMGT/GENE-DB) and one three-dimensional structure database (IMGT/3Dstructure-DB), interactive tools for sequence analysis (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/Allele-Align), for genome analysis (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView) and for 3D structure analysis (IMGT/StructuralQuery), and Web resources ("IMGT Marie-Paule page") comprising 8000 HTML pages. IMGT other accesses include SRS, FTP, search by BLAST, etc. By its high quality and its easy data distribution, IMGT has important implications in medical research (repertoire in autoimmune diseases, AIDS, leukemias, lymphomas, myelomas), veterinary research, genome diversity and genome evolution studies of the adaptive immune responses, biotechnology related to antibody engineering (scFv, phage displays, combinatorial libraries) and therapeutical approaches (grafts, immunotherapy). IMGT is freely available at http://imgt.cines.fr.
Lefranc
Marie-Paule
MP
IMGT, the international ImMunoGeneTics information system. Universite Montpellier II, Laboratoire d'ImmunoGenetique Moleculaire LIGM UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France. lefranc@ligm.igh.cnrs.fr
Giudicelli
Véronique
V
Ginestoux
Chantal
C
Bosc
Nathalie
N
Folch
Géraldine
G
Guiraudou
Delphine
D
Jabado-Michaloud
Joumana
J
Magris
Séverine
S
Scaviner
Dominique
D
Thouvenin
Valérie
V
Combres
Kora
K
Girod
David
D
Jeanjean
Stéphanie
S
Protat
Céline
C
Yousfi-Monod
Mehdi
M
Duprat
Elodie
E
Kaas
Quentin
Q
Pommié
Christelle
C
Chaume
Denys
D
Lefranc
Gérard
G
D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D005803:Genes, Immunoglobulin / Q000235:genetics; D019672:Genes, T-Cell Receptor / Q000235:genetics; D006801:Humans; D007125:Immunogenetics