Inactivating Cdc25, mitotic style.
Mitotic entry and exit require activation and inactivation of the Cdk1-cyclin B kinase complex, respectively. The Cdc25 protein phosphatase family activates Cdk1-cyclin B at the G2/M transition by removing inhibitory phosphate groups. Cdc25 family members, held inactive during interphase, are activated during mitotic progression in an amplification loop involving Cdk1-cyclin B. While Cdc25 activation at the G2/M transition is required for the timely initiation of mitosis, recent evidence suggests that the inactivation of Cdc25 in late mitosis may play a role in supporting Cdk1-cyclin B inactivation. Here, we discuss the mechanisms of Cdc25 regulation and how they pertain to both mitotic entry and exit.
Wolfe
Benjamin A
BA
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232, USA.
Gould
Kathleen L
KL
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D019926:Cyclin B / Q000378:metabolism; D004789:Enzyme Activation; D008938:Mitosis / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D014982:Xenopus laevis; D020687:cdc25 Phosphatases / Q000378:metabolism*
D019926:Cyclin B; D029701:Saccharomyces cerevisiae Proteins; D016203:CDC2 Protein Kinase; D020687:cdc25 Phosphatases