title: Baylis-Hillman reaction assisted parallel synthesis of 3,5-disubstituted isoxazoles and their in vivo bioevaluation as antithrombotic agents.
abstract: The solution-phase parallel synthesis involving reactions of Baylis-Hillman products of 3-substituted-5-isoxazolecarbaldehydes with nucleophiles and their in vivo antithrombotic evaluations are described along with the results of in vitro platelet aggregation inhibition assay of a few compounds. Results of the detailed evaluation of one of the compounds as an inhibitor of platelet aggregation are also presented.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226 001, India. batra-san@yahoo.co.uk
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: A K
authors.initials: AK
authors.lastname: Roy
authors.forename: A
authors.initials: A
authors.lastname: Patra
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: W R
authors.initials: WR
authors.lastname: Surin
authors.forename: S A V
authors.initials: SA
authors.lastname: Raghavan
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: K
authors.initials: K
authors.lastname: Kapoor
authors.forename: M
authors.initials: M
authors.lastname: Dikshit
mesh_terms: D000818:Animals; D000991:Antithrombins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000991:Antithrombins; D007555:Isoxazoles