title: Early-onset sigmoid colon perforation during concurrent chemoradiation in a patient with cervical cancer.
abstract: Radiation-induced colon perforation is a rare adverse effect caused by vascular and connective tissue injury to the rectosigmoid colon. It usually occurs a few months to years after radiotherapy for gynecological cancer. Herein, we present a patient who developed sigmoid colon perforation during concurrent chemoradiotherapy for cervical cancer. The patient was a 64-year-old clinical stage IIB woman who received concurrent chemoradiotherapy as a standard treatment. The chemotherapeutic protocol was cisplatin 50 mg/m(2) and 5-fluorouracil 4000 mg, starting together with radiotherapy. After the completion of external beam radiation for 4500 cGy, the patient developed sigmoid colon perforation presenting with fecal peritoneum and sepsis. An emergency end ileostomy with resection of entire sigmoid colon was performed and the patient was discharged 3 months later in good condition. Clinicians must be highly suspicious of serious bowel perforation, even if the full dose of radiation has not been completed. Whether or not the chemotherapy was the trigger factor is in need of further clarification.
authors.affiliation: Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan, Republic of China. haolin@adm.cgmh.org.tw
authors.forename: H
authors.initials: H
authors.lastname: Lin
authors.forename: C-L
authors.initials: CL
authors.lastname: Chang
authors.forename: E-Y
authors.initials: EY
authors.lastname: Huang
authors.forename: C-C
authors.initials: CC
authors.lastname: Changchien
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011878:Radiotherapy / Q000009:adverse effects; D012810:Sigmoid Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil