title: Mycobacterium tuberculosis infections in eight species at the National Zoological Gardens of South Africa, 1991-2001.
abstract: Between 1991 and 2001 a total of 12 cases of Mycobacterium tuberculosis infection in eight different species were recorded in the National Zoological Gardens of South Africa in Pretoria (Tshwane). The genetic relatedness between seven of the M. tuberculosis isolates was determined by IS6110 restriction fragment length polymorphism analysis. For the majority of isolates that were analyzed, a high degree of polymorphism suggested different sources of infection. Evidence of M. tuberculosis transmission between animals is reported in two chimpanzees (Pan troglodytes) housed together, from which samples were collected for analysis 29 mo apart.
authors.affiliation: Tuberculosis Laboratory, ARC-Onderstepoort Veterinary Institute, Private Bag x 05, Onderstepoort 0110, South Africa.
authors.forename: Anita L
authors.initials: AL
authors.lastname: Michel
authors.forename: Leon
authors.initials: L
authors.lastname: Venter
authors.forename: Ian W
authors.initials: IW
authors.lastname: Espie
authors.forename: Morné L
authors.initials: ML
authors.lastname: Coetzee
mesh_terms: D000818:Animals; D000836:Animals, Zoo / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D015139:Blotting, Southern; D004269:DNA, Bacterial / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012150:Polymorphism, Restriction Fragment Length; D013019:South Africa / Q000453:epidemiology; D014376:Tuberculosis / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission / Q000662:veterinary*
chemical_list: D004269:DNA, Bacterial