title: Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people.
abstract: The effect of the synthetic peptide bioregulator Vilon on structural and facultative heterochromatin of cultured lymphocytes from old people has been studied. The data obtained indicate that Vilon (a) induces unrolling (deheterochromatinization) of total heterochromatin; (b) activates synthetic processes caused by the reactivation of ribosomal genes as a result of deheterochromatinization of nucleolus organizer regions; (c) releases the genes repressed due to the condensation of euchromatic regions forming facultative heterochromatin; (d) does not induce decondensation of pericentromeric structural heterochromatin. Our results indicate that Vilon causes progressive activation (deheterochromatinization) of the facultative heterochromatin with increased aging.
authors.affiliation: Department of Genetics, Tbilisi State University, Tbilisi, Georgia. lezh@kheta.ge
authors.forename: Teimuraz
authors.initials: T
authors.lastname: Lezhava
authors.forename: Vladimir
authors.initials: V
authors.lastname: Khavison
authors.forename: Jamlet
authors.initials: J
authors.lastname: Monaselidze
authors.forename: Tinatin
authors.initials: T
authors.lastname: Jokhadze
authors.forename: Nana
authors.initials: N
authors.lastname: Dvalishvili
authors.forename: Nino
authors.initials: N
authors.lastname: Bablishvili
authors.forename: Shota
authors.initials: S
authors.lastname: Barbakadze
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D002152:Calorimetry, Differential Scanning; D002478:Cells, Cultured; D004151:Dipeptides / Q000494:pharmacology*; D005786:Gene Expression Regulation; D006570:Heterochromatin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D011110:Polymorphism, Genetic; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism
chemical_list: D004151:Dipeptides; D006570:Heterochromatin; C415909:lysylglutamic acid