title: Coeliac disease and hereditary haemochromatosis: association and implications.
abstract: Coeliac disease and hereditary haemochromatosis are genetic disorders paradoxically associated with altered intestinal absorption of iron. Hereditary haemochromatosis is the most common autosomal recessive disease in the Caucasian population and is characterised by an iron overload state. Coeliac disease, or gluten sensitive enteropathy, on the other hand is frequently associated with iron deficiency anaemia. We report the cases of two patients who developed both coeliac disease and hereditary haemochromatosis. We review the literature of this rare association and examine how the clinical presentation is modified by their co-existence and the potential genetic linkage of these two disorders.
authors.affiliation: Integrated Department of Gastroenterology, Bradford Teaching Hospitals NHS Trust, West Yorkshire, UK. amitasinghal@hotmail.com
authors.forename: Amit
authors.initials: A
authors.lastname: Singhal
authors.forename: Sulleman
authors.initials: S
authors.lastname: Moreea
authors.forename: Paul D
authors.initials: PD
authors.lastname: Reynolds
authors.forename: Khalid I
authors.initials: KI
authors.lastname: Bzeizi
mesh_terms: D002446:Celiac Disease / Q000150:complications* / Q000378:metabolism; D005260:Female; D006432:Hemochromatosis / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism; D008875:Middle Aged
chemical_list: D007501:Iron