Seronegative infection and AIDS caused by an A2 subsubtype HIV-1.
The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.
Cardoso
Ana R
AR
Hospital Nossa Senhora da Graça, Tomar, Portugal.
Gonçalves
Cristina
C
Pascoalinho
Dulce
D
Gil
Carla
C
Ferreira
António F
AF
Bártolo
Inês
I
Taveira
Nuno
N
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D000328:Adult; D005260:Female; D018023:HIV Seronegativity; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology; D006801:Humans; D010802:Phylogeny