[The genotype analysis of beta adrenergic receptor gene family in high risk population of hypertension in northeast China].
OBJECTIVE
To investigate the genotype of Arg389Gly polymorphism in beta(1)-adrenergic receptor gene(beta(1)-AR), Arg16Gly polymorphism in beta(2)-adrenergic receptor gene (beta(2)-AR) and Trp64Arg polymorphism in beta(3)-adrenergic receptor gene (beta(3)-AR) in the high risk population of hypertension and analyze the role of the genes in the pathogenesis of essential hypertension.


METHODS
PCR-restriction fragment length polymorphism was used to detect the genotypes of 144 hypertensives and 174 normotensives, and some biochemical indexes were tested. The association of the polymorphisms with essential hypertension was assessed in a case-control study.


RESULTS
The frequency of homozygote for the Gly389 allele of the beta(1)-AR was significantly higher in hypertensives than in normotensives. No statistically significant differences were found in the frequencies of Arg16Gly of beta(2)-AR and Trp64Arg of beta(3)-AR between hypertensives and normotensives.


CONCLUSIONS
In this study, Arg389Gly polymorphism of beta(1)-AR was involved in the pathogenesis of hypertension. Individuals homozygous for the Gly389 allele of the beta(1)-AR are at increased risk of developing hypertension.
Liang
Yu
Y
Department of Medical Genetics, China Medical University, Shenyang, Liaoning, 110001 PR China.
Zhao
Yan-yan
YY
Liu
Hong
H
Shi
Jing-pu
JP
D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011943:Receptors, Adrenergic, beta / Q000235:genetics*
D011943:Receptors, Adrenergic, beta