Molecular monitoring to identify a threshold of CBFbeta/MYH11 transcript below which continuous complete remission of acute myeloid leukemia inv16 is likely.
Many patients with the inv(16) positive acute myeloid leukemia (AML) achieve complete remission (CR). Using real-time reverse transcriptase polymerase chain reaction (RT-PCR), we previously proposed critical CBFbeta-MYH11 transcript copy number thresholds to predict relapse or cure. We now update the molecular follow-up of our patients, also presenting the therapeutic management of these patients.
Martinelli
Giovanni
G
Rondoni
Michela
M
Buonamici
Silvia
S
Ottaviani
Emanuela
E
Piccaluga
Pier Paolo
PP
Malagola
Michele
M
Baccarani
Michele
M
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000175:diagnosis; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D012074:Remission Induction; D012189:Retrospective Studies
C095514:CBFbeta-MYH11 fusion protein; D015514:Oncogene Proteins, Fusion; D012333:RNA, Messenger