title: CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes).
abstract: Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.
authors.affiliation: Department of Pathology, Children's Medical Center of Dallas and the University of Texas Southwestern Medical Center, Dallas, TX, USA. dinesh.rakheja@utsouthwestern.edu
authors.forename: Dinesh
authors.initials: D
authors.lastname: Rakheja
authors.forename: Srinivas B
authors.initials: SB
authors.lastname: Narayan
authors.forename: Johanne V
authors.initials: JV
authors.lastname: Pastor
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bennett
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002417:Cattle; D002784:Cholesterol / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D021962:Membrane Microdomains / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics / Q000378:metabolism; D019308:Palmitic Acid / Q000302:isolation & purification; D011233:Precipitin Tests
chemical_list: D008565:Membrane Proteins; D019308:Palmitic Acid; D002784:Cholesterol