The role of Y chromosome C-band size polymorphism in male infertility with a reference to their effect on the total length of the chromosome.
OBJECTIVE
To assess the contribution of chromosome on sperm production.


METHODS
During a 2 year period from October 1999 to December 2001 a total of 200 male patients were included in the present study. The study was carried out at Kufa Medical College, Kufa, Iraq. Blood culture, chromosomal harvesting, Giemsa stain, C-band technique and C-band size calculation have been conducted according to the standard methods.


RESULTS
No statistical differences have been recorded in the C-band size distribution level among the infertile groups compared to normal control. The functional relationship between C-band, euchromatin and the total length of the Y chromosome showed a strong correlation coefficient among the infertile groups (oligospermia, azoospermia) as well as the normal control.


CONCLUSIONS
In our qualitative study the C-band size of the Y chromosome has no effect on spermatogenesis. The decrease in the size of Y chromosome is due to the decrease in both the heterochromatin and euchromatin regions.
Yasseen
Akeel A
AA
Department of Pathology and Forensic Medicine, College of Medicine, Kufa University, Kufa, Iraq. akeelyasseen@hotmail.com
Al-Khafaji
Salih M
SM
D016022:Case-Control Studies; D002871:Chromosome Banding; D041322:Chromosomes, Human, Y; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D013091:Spermatogenesis / Q000235:genetics