How T cells use LFA-1 to attach and migrate.
The T lymphocyte (or T cell) has classically been perceived to be a passive circular cell attaching to other cells or fibrils of the extracellular matrix when its integrins become activated. We now understand that the modus operandi of the T cell is migration. These cells are proving to be impressively fast migrators, clocking up basal speeds of approximately 10-15 microm/min which makes them amongst the fastest movers recorded to date. Therefore, migration is the business of the T cell and in this review we will discuss how its motility is regulated and what functions this activity makes possible.
Hogg
Nancy
N
Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK. nancy.hogg@cancer.org.uk
Smith
Andrew
A
McDowall
Alison
A
Giles
Katherine
K
Stanley
Paula
P
Laschinger
Melanie
M
Henderson
Robert
R
D000818:Animals; D002448:Cell Adhesion / Q000276:immunology / Q000502:physiology; D002465:Cell Movement / Q000276:immunology / Q000502:physiology*; D003599:Cytoskeleton / Q000276:immunology / Q000502:physiology; D006801:Humans; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D013915:Thrombasthenia / Q000276:immunology
D016169:Lymphocyte Function-Associated Antigen-1