Destructive arthritis in a patient with Haim-munk syndrome.
Haim-Munk and Papillon-Lefèvre are 2 closely related syndromes, inherited in an autosomal recessive pattern, manifested by palmoplantar keratoderma and early, destructive periodontitis. Recently, mutations in the cathepsin C gene have been recognized in both syndromes. We describe a patient with Haim-Munk syndrome (palmar plantar keratosis and periodontitis) and destructive arthritis of the wrists and shoulder joints, an association that has not been previously described.
Lidar
Merav
M
Department of Medicine B and Rheumatology Unit, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel.
Zlotogorski
Abraham
A
Langevitz
Pnina
P
Tweezer-Zaks
Nurit
N
Zandman-Goddard
Gisele
G
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001168:Arthritis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D001175:Arthrography; D005260:Female; D005385:Fingers / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010518:Periodontitis / Q000473:pathology*; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000473:pathology; D013577:Syndrome; D014955:Wrist Joint / Q000000981:diagnostic imaging / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal