title: Novel chiral dendritic diphosphine ligands for Rh(I)-catalyzed asymmetric hydrogenation: remarkable structural effects on catalytic properties.
abstract: [reaction: see text] A series of dendritic ligands with a chiral diphosphine located at the focal point have been synthesized through coupling of pyrphos 2 with Fréchet-type polyether dendron 3. The relationship between the primary structure of the dendrimer and its catalytic properties was established in the Rh-catalyzed asymmetric hydrogenation of alpha-acetamido cinnamic acid 4. A remarkable structural effect on catalytic activity was observed.
authors.affiliation: Laboratory of Chemical Biology, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Yi
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Fan
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Deng
authors.forename: Yue-Ming
authors.initials: YM
authors.lastname: Li
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Qiu
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan