title: [Content change of collagen I, III in liver and spleen of patients with advanced schistosomiasis japonica].
abstract: OBJECTIVE
  To study the change of the content of collagen type I and collagen type III (C-I, C-III) in liver and spleen of patients with advanced schistosomiasis japonica.
  
  
  METHODS
  Sirius red staining was used to examine pathologically the liver and spleen biopsy materials from 55 patients at the advanced stage of schistosomiasis and 5 healthy persons as control. The stained slides were observed under polarizing microscope and results were interpreted by computer imaging analysis system.
  
  
  RESULTS
  The content of C-I and C-III in liver tissue and hepatic sinusoids increased significantly in the patients than that of the control (P < 0.01), the ratio of C-I/C-III decreased considerably (P < 0.01). With the progress of fibrosis in the liver, the content of C-I and C-III in hepatic sinusoids decreased, and the ratio of C-I/C-III increased. The content of C-I and C-III in spleen tissue also increased significantly in schistosomiasis patients than that of the control (P < 0.01), the ratio of C-I/C-III decreased (P < 0.01). The C-I and C-III content increased with the progress of spleen fibrosis while the ratio of C-I/C-III decreased.
  
  
  CONCLUSIONS
  The result shows that the content of C-I and C-III increased in liver and spleen of the patients with advanced schistosomiasis japonica, the increase of C-III was more significant than that of C-I.
authors.affiliation: Department of Pathology, First Municipal Hospital, Jiaxing 314000.
authors.forename: Jia-lin
authors.initials: JL
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.forename: Wei-min
authors.initials: WM
authors.lastname: Cai
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D024042:Collagen Type I / Q000378:metabolism*; D024061:Collagen Type III / Q000378:metabolism*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012554:Schistosomiasis japonica / Q000378:metabolism*; D013154:Spleen / Q000378:metabolism* / Q000473:pathology
chemical_list: D024042:Collagen Type I; D024061:Collagen Type III