Nuclear transcription factor NF-kappa B: role in biology and medicine.
The inducible transcription factor nuclear factor-kappa B (NF-kappaB) plays a central role in regulation of many immune, inflammatory and carcinogenic responses. While normal activation of NF-kappaB is required for cell survival and immunity, aberrant regulation of NF-kappaB leads to development of many pathological states especially those involved in acute inflammation. Recent advances in our knowledge of the signaling mechanisms those control the activation of NF-kappaB highlights the intriguing aspect of NF-kappaB regulation, namely the ability of many different signal transduction pathways originating from a wide variety of inducing mechanisms to converge on a single target, the NF-kappaB/IkappaB complex. In this review we summarize our current understanding of the NF-kappaB signaling pathways, their role in various cellular responses and the potential of using NF-kappaB as a therapeutic target in modern medicine.
Aggarwal
Bharat B
BB
Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. Aggarwal@mdanderson.org
Takada
Yasunari
Y
Shishodia
Shishir
S
Gutierrez
Angelica M
AM
Oommen
Oommen V
OV
Ichikawa
Haruyo
H
Baba
Yuh
Y
Kumar
Ashok
A
D000818:Animals; D001695:Biology; D004194:Disease; D006801:Humans; D016328:NF-kappa B / Q000502:physiology*
D016328:NF-kappa B