title: Structure, function and evolution of multidomain proteins.
abstract: Proteins are composed of evolutionary units called domains; the majority of proteins consist of at least two domains. These domains and nature of their interactions determine the function of the protein. The roles that combinations of domains play in the formation of the protein repertoire have been found by analysis of domain assignments to genome sequences. Additional findings on the geometry of domains have been gained from examination of three-dimensional protein structures. Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations.
authors.affiliation: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. cvogel@mrc-lmb.cam.ac.uk
authors.forename: Christine
authors.initials: C
authors.lastname: Vogel
authors.forename: Matthew
authors.initials: M
authors.lastname: Bashton
authors.forename: Nicola D
authors.initials: ND
authors.lastname: Kerrison
authors.forename: Cyrus
authors.initials: C
authors.lastname: Chothia
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Teichmann
mesh_terms: D003198:Computer Simulation; D019143:Evolution, Molecular; D017434:Protein Structure, Tertiary; D012984:Software