Trace element status in plasma and erythrocytes in hyperemesis gravidarum.
OBJECTIVE
To determine trace element status in plasma and erythrocytes hyperemetic women at presentation and after treatment.


METHODS
Studies were carried out on 32 women with hyperemesis gravidarum. Thirteen non-vomiting, healthy, pregnant women served as controls. Copper, zinc and magnesium concentrations in both plasma and erythrocytes were estimated before and after treatment. Independent sample t test, paired sample t test, Wilcoxon signed rank test, Mann-Whitney U test, chi2 test, Kruskall-Wallis one-way analysis of variance and Spearman's correlation study were used for statistical analysis.


RESULTS
There were no significant differences between the 2 groups in erythrocyte zinc, copper and magnesium concentration. Plasma zinc levels were significantly higher (P = .006), while plasma copper levels were significantly lower (P = .001) in the study group as compared to the controls, but plasma magnesium levels were not significantly altered. Treatment brought a significant decrease in plasma zinc levels (P = .001), increase in plasma copper concentration (P = .001) but no change in erythrocyte zinc, copper or magnesium concentration. When trace element levels were grouped according to the degree of ketonuria, no significant differences were found in the 2 groups.


CONCLUSIONS
Hyperemetic women had normal tissue zinc, copper and magnesium concentrations, and rehydration normalized the plasma zinc and copper levels. Otherwise, no significant effects on trace elements were noted.
Dökmeci
Fulya
F
Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
Engin-Ustün
Yaprak
Y
Ustün
Yusuf
Y
Kavas
Güzin Ozelçi
GO
Kocatürk
Pelin Aribal
PA
D000328:Adult; D016022:Case-Control Studies; D003300:Copper / Q000097:blood / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood*; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D014131:Trace Elements / Q000097:blood / Q000378:metabolism*; D015032:Zinc / Q000097:blood / Q000378:metabolism
D014131:Trace Elements; D003300:Copper; D008274:Magnesium; D015032:Zinc