[Antiviral activity of an interferon inducer amixin in experimental West Nile Fever].
Experimental research was undertaken to investigate the use of amixin in prevention, emergency prevention schemes and treatment of mice infected with West Nile fever (WNF) agent, strain Eg-101; the results are indicative of the drug efficiency both in its peroral and subcutaneous administrations. Amixin was shown to be most effective in the former case when administered, 10 mg/kg, in 96 hours before mice were infected as well as during the entire incubation period: lethality protection--46%. In the latter case, the drug was effective, when 3 administration schemes were in use, 10 mg/kg. The maximum degree of protection efficiency was registered with amixin administration according to the emergency prevention scheme: lethality protection--33%. The drug suppresses effectively the WNF virus reproduction in cerebral tissues.
Loginova
S Ia
SIa
Koval'chuk
A V
AV
Borisevich
S V
SV
Syromiatnikova
S I
SI
Borisevich
G V
GV
Pashchenko
Iu I
IuI
Khamitov
R A
RA
Maksimov
V A
VA
Shuster
A M
AM
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D001921:Brain / Q000821:virology; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous; D007372:Interferons / Q000097:blood; D051379:Mice; D013994:Tilorone / Q000627:therapeutic use*; D014901:West Nile Fever / Q000097:blood / Q000188:drug therapy*; D014902:West Nile virus / Q000187:drug effects / Q000302:isolation & purification
D000998:Antiviral Agents; D007372:Interferons; D013994:Tilorone