Meet the relatives: a family of BPI- and LBP-related proteins.
Until recently, two key members of the innate immune response to Gram negative bacteria, bactericidal permeability-increasing protein (BPI) and lipopolysaccharide (LPS)-binding protein, have been considered to be members of a small family of lipid-binding proteins that also contains cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP). A recent paper has characterised three related proteins that are expressed in the mouth, nose and upper airways. Taken together with other recent data, it is clear that a large family of such proteins exists and these additional members might also function in the innate immune response.
Bingle
Colin D
CD
Academic Unit of Respiratory Medicine, Division of Genomic Medicine, University of Sheffield Medical School, UK. c.d.bingle@sheffield.ac.uk
Craven
C Jeremy
CJ
D000209:Acute-Phase Proteins; D000818:Animals; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000235:genetics / Q000276:immunology*; D002352:Carrier Proteins / Q000235:genetics / Q000276:immunology*; D053480:Cholesterol Ester Transfer Proteins; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology* / Q000502:physiology; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology; D005810:Multigene Family / Q000235:genetics; D049294:Phospholipid Transfer Proteins; D010750:Phosphoproteins / Q000235:genetics / Q000276:immunology; D000099231:Lipopolysaccharide-Binding Protein
D000209:Acute-Phase Proteins; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins; D010750:Phosphoproteins; D000099231:Lipopolysaccharide-Binding Protein; C485599:BPIFA1 protein, human; C506642:CETP protein, human; C021623:bactericidal permeability increasing protein