The common and distinct target genes of the p53 family transcription factors.
p53 is the most commonly mutated gene in human cancer. After activation by cellular stresses such as DNA damage or oncogene activation, p53, a sequence-specific DNA-binding protein, induces the expression of target genes which mediate tumor suppression. Two recently identified p53 homologues, p63 and p73, appear to function similarly to p53, that is, they both activate target gene expression and suppress cell growth when overexpressed; however, the p63 and p73 genes are rarely mutated in human cancer and do not adhere to Knudson's classical model of a tumor suppressor gene. Recently, exciting observations suggest nonoverlapping functions for the family members. Herein, we outline the recent literatures identifying and characterizing both the common and distinct target genes of the p53 family transcription factors in relation to their signaling pathways.
Harms
K
K
Department of Cell Biology, University of Alabama at Birmingham, 1918 University Blvd., Birmingham, Alabama 35294, USA.
Nozell
S
S
Chen
X
X
D017209:Apoptosis / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology; D004260:DNA Repair; D005786:Gene Expression Regulation; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000378:metabolism; D009389:Neovascularization, Pathologic; D020033:Protein Isoforms / Q000235:genetics* / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
D020033:Protein Isoforms; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53