title: Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease.
abstract: The authors studied whether olfactory dysfunction is present in parkin disease using the University of Pennsylvania Smell Identification Test (UPSIT). The mean UPSIT score in parkin patients was 27.3 (95% CI 24.4 to 30.2). This did not differ from the normal group mean of 29.4 (95% CI 28.0 to 30.7; p = 0.22) but was higher than the Parkinson disease group (mean 14.3; 95% CI 12.2 to 19.5; p < 0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p < 0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease.
authors.affiliation: Department of Molecular Neurosciences, Institute of Neurology, London School of Hygiene and Tropical Medicine, University College London, UK.
authors.forename: N L
authors.initials: NL
authors.lastname: Khan
authors.forename: R
authors.initials: R
authors.lastname: Katzenschlager
authors.forename: H
authors.initials: H
authors.lastname: Watt
authors.forename: K P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: N W
authors.initials: NW
authors.lastname: Wood
authors.forename: N
authors.initials: N
authors.lastname: Quinn
authors.forename: A J
authors.initials: AJ
authors.lastname: Lees
mesh_terms: D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000453:epidemiology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D011237:Predictive Value of Tests; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein