title: Uncertainties in dose coefficients from ingestion of 131I, 137Cs, and 90Sr.
abstract: Quantification of uncertainties in doses from intakes of radionuclides is important in risk assessments and epidemiologic studies of individuals exposed to radiation. In this study, the uncertainties in the doses per unit intake (i.e., dose coefficients) for ingestion of 131I, 137Cs, and 90Sr by healthy individuals have been determined. Age-dependent thyroid dose coefficients were derived for 131I. The analysis for 131I uses recent measurements of thyroid volume obtained by ultrasonography, which indicate a thyroid mass lower than that previously obtained using autopsy measurements. The coefficients for 137Cs are determined using the relationship between the biological half-lives and the amount of potassium in the human body. The most recent International Commission on Radiological Protection biokinetic model was employed to determine the uncertainties for 90Sr. For 137Cs and 90Sr, the dose coefficients represent exposure in adulthood and they were determined for all organs of radiological importance. The uncertainty in the estimated dose coefficients represent state of knowledge estimates for a reference individual, and they are described by lognormal distributions with a specified geometric mean (GM) and geometric standard deviation (GSD). The estimated geometric means vary only slightly from the dose coefficients reported by ICRP publications. The largest uncertainty is observed in the dose coefficients for bone surface (GSD = 2.6), and red bone marrow (GSD = 2.4) in the case of ingestion of 90Sr. For most other organs, the uncertainty in the 90Sr dose coefficients is characterized by a GSD of 1.8 (or less for some organs). For 131I, the uncertainty in the thyroid dose coefficients is well represented by a GSD of 1.7 for both sexes and all ages other than infants for whom a GSD of 1.8 is more appropriate. The lowest uncertainties are obtained for the dose coefficients from ingestion of 137Cs (GSD = 1.24 for males; 1.4 for females). A dominant source of uncertainty in the ingestion dose coefficients is the variation of the biokinetic parameters. For 131I, the largest contribution to the uncertainty comes from the variation in the thyroid mass, but the contribution of the biokinetic parameters is comparable. The biokinetic parameters with the largest contribution to the uncertainty are (a) the fractional uptake from blood to thyroid in the case of ingestion of 131I, (b) the absorbed fraction from the gastrointestinal tract (f1) in the case of 90Sr, and (c) the amount of potassium in the body for 137Cs. The contribution to the uncertainty of the absorbed fraction (which accounts for the fraction of energy deposited in the target organ) is the smallest contributor to the uncertainty in the dose coefficients for most organs. To reduce the uncertainty in the dose estimated for a real individual, one should determine the above-mentioned parameters for the specified individual rather than to rely on assumptions for a reference individual.
authors.affiliation: SENES Oak Ridge, Inc., 102 Donner Drive, Oak Ridge, TN 37830, USA. iulian@senes.com
authors.forename: A Iulian
authors.initials: AI
authors.lastname: Apostoaei
authors.forename: Laurence F
authors.initials: LF
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001822:Body Burden; D002588:Cesium Radioisotopes / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D004064:Digestive System / Q000378:metabolism*; D005260:Female; D005507:Food Contamination, Radioactive / Q000032:analysis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D015233:Models, Statistical; D009928:Organ Specificity; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013326:Strontium Radioisotopes / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D013961:Thyroid Gland / Q000378:metabolism*
chemical_list: D002588:Cesium Radioisotopes; D007457:Iodine Radioisotopes; D013326:Strontium Radioisotopes