Natural interferon alpha treatment and interferon alpha receptor 2 levels in acute hepatitis C.
Efficacy of interferon (IFN) therapy during the acute phase of hepatitis C infection is promising, although the optimal regimen has yet to be determined. It is not known whether the known prognostic factors for chronic hepatitis C (CHC) influence the effect of IFN in acute hepatitis C (AHC). Seventeen patients with AHC were analyzed for hepatic IFN alpha receptor 2 (IFNAR2) prior to IFN treatment. All patients were subsequently treated with either 168 million units (MU) or 336 MU of natural IFN alpha. Seventeen age-matched samples of CHC were provided as controls. The overall sustained response rate was 64.7% (11/17). In patients who received a total dose of 168 MU IFN, the sustained response rate was 28.6% (2/7), and in those who received 336 MU of IFN, the sustained response rate was 90.0% (9/10). The peaks of ALT and HCV-RNA quantity were not associated with the response to IFN. The hepatic IFNAR2 levels were 1.52 +/- 0.34 densitometry units and 0.92 +/- 0.16 in AHC and CHC, respectively (P = 0.042). There was no difference in hepatic IFNAR2 levels between sustained virological responders (SVR) and nonsustained virological responders (NR). The hepatic receptor levels were higher in AHC than in CHC patients. The levels of hepatic IFNAR2 did not differ in SVR and NR, indicating that high-dose natural IFN alpha treatment is effective for AHC, irrespective of the levels of hepatic IFNAR2.
Ohata
Kazuyuki
K
Institute for Clinical Research, WHO Collaborating Center for Reference and Research on Viral Hepatitis, National Nagasaki Medical Center, Nagasaki 856-8562, Japan.
Yano
Koji
K
Yatsuhashi
Hiroshi
H
Daikoku
Manabu
M
Koga
Michiaki
M
Eguchi
Katsumi
K
Yano
Michitami
M
D000208:Acute Disease; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy* / Q000378:metabolism*; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D020033:Protein Isoforms / Q000378:metabolism; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000378:metabolism*; D012189:Retrospective Studies
D000998:Antiviral Agents; C508033:IFNAR2 protein, human; D016898:Interferon-alpha; D008565:Membrane Proteins; D020033:Protein Isoforms; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta