Plasticity of GABAergic synapses in the neonatal rat hippocampus.
While the development and plasticity of excitatory synaptic connections have been studied into detail, little is known about the development of inhibitory synapses. As proposed for excitatory synapses, recent studies have indicated that activity-dependent forms of synaptic plasticity, such as long-term potentiation and long-term depression, may play a role in the establishment of functional inhibitory synaptic connections. Here, I review these different forms of plasticity and focus on their possible role in the developing neuronal network.
Gaïarsa
J-L
JL
Institut de Neurobiologie de la Méditerranée (INMED), Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 29, Marseille, France. gaiarsa@inmed.univ-mrs.fr
D000818:Animals; D000831:Animals, Newborn; D018757:GABA Modulators / Q000737:chemistry*; D006624:Hippocampus / Q000166:cytology*; D017774:Long-Term Potentiation; D008954:Models, Biological; D009415:Nerve Net; D009473:Neuronal Plasticity; D051381:Rats; D013569:Synapses / Q000473:pathology / Q000502:physiology*; D009435:Synaptic Transmission
D018757:GABA Modulators