Stochastic heart-rate model can reveal pathologic cardiac dynamics.
A simple one-dimensional Langevin-type stochastic difference equation can simulate the heart-rate fluctuations in a time scale from minutes to hours. The model consists of a deterministic nonlinear part and a stochastic part typical of Gaussian noise, and both parts can be directly determined from measured heart-rate data. Data from healthy subjects typically exhibit the deterministic part with two or more stable fixed points. Studies of 15 congestive heart-failure subjects reveal that the deterministic part of pathologic heart dynamics has no clear stable fixed points. Direct simulations of the stochastic model for normal and pathologic cases can produce statistical parameters similar to those of real subjects. Results directly indicate that pathologic situations simplify the heart-rate control system.
Kuusela
Tom
T
Department of Physics, University of Turku, 20014 Turku, Finland. tom.kuusela@utu.fi
D003198:Computer Simulation; D004562:Electrocardiography / Q000379:methods*; D006329:Heart Conduction System / Q000503:physiopathology*; D006333:Heart Failure / Q000175:diagnosis / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008955:Models, Cardiovascular; D008959:Models, Neurological; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D016011:Normal Distribution; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013269:Stochastic Processes