title: Synthesis and peptide binding properties of methoxypyrrole amino acids (MOPAS).
abstract: [structure: see text] Methoxypyrrole amino acids (MOPAS) have been prepared and were introduced into small peptides with hairpin structures. The intra- and intermolecular binding properties of this heterocyclic amino acid mimicking a dipeptido beta-strand was investigated by NMR titration and X-ray crystal structure analysis. The data reveal a hydrogen bonding pattern that is complementary to a peptide beta-sheet.
authors.affiliation: Institut für Organische Chemie and Zentrale Analytik, Universität Regensburg, D-93040 Regensburg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Bonauer
authors.forename: Manfred
authors.initials: M
authors.lastname: Zabel
authors.forename: Burkhard
authors.initials: B
authors.lastname: König
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D009842:Oligopeptides; D011758:Pyrroles