title: [Aggressive digital papillary adenocarcinoma: a case report].
abstract: OBJECTIVE
  We describe a case of Aggressive Digital Papillary Adenocarcinoma, a rare skin neoplasm with acral location.
  
  
  RESULTS
  The patient, a 66 year old man, presented with an ulcerated mass of the fifth toe of the left foot, 4.4 cm in size. Histologically the tumour was characterized by a solid-cystic structure, with extensive papillary component, comedo necrosis and focal eccrine differentiation. Immunohistochemistry showed diffuse positivity for cytokeratins AE1/AE3 and 7, and, focal staining for Muscle Specific Actin, Vimentin and EMA. Chest CT scan showed the presence of a single pulmonary node, whose cytological features were consistent with a metastatic disease.
  
  
  CONCLUSIONS
  The clinico-pathological features of the present are similar to those previously reported in the literature and confirms the aggressive nature of this neoplasm.
authors.affiliation: Servizio di Anatomia Patologica e Citologia Diagnostica, Ospedale Giovanni Bosco, Torino. Andrea.Demarchi@aslto4.it
authors.forename: A
authors.initials: A
authors.lastname: Demarchi
authors.forename: D
authors.initials: D
authors.lastname: Bellis
authors.forename: R
authors.initials: R
authors.lastname: Nunziata
authors.forename: S
authors.initials: S
authors.lastname: Coverlizza
mesh_terms: D000199:Actins / Q000032:analysis; D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000473:pathology / Q000556:secondary*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002454:Cell Differentiation; D005534:Foot Diseases / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D013544:Sweat Gland Neoplasms / Q000473:pathology*; D014034:Toes / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D018396:Mucin-1; D009363:Neoplasm Proteins; D014746:Vimentin; D007633:Keratins