Modulation of functional connectivity during the resting state and the motor task.
Quite a few studies in functional magnetic resonance imaging (fMRI) have tested that, even in a resting state, motor cortices constitute a network. It has never been investigated how the network modulates from the resting state to the motor task state. In this report, by a newly developed approach taking into account n-to-1 connectivity using 1-to-1 connectivity measures instead of conventional pairwise connectivity, we show the existence of a large organized functional connectivity network related to motor function in the resting brain with fMRI. More importantly, we found that such a network can be modulated from a conscious resting state to planning, initiation, coordination, guidance, and termination of voluntary movement state, exhibited by significant changes of functional connectivity of some brain regions in different brain activity. Moreover, a quantitative description of such a functional modulation has also been presented.
Jiang
Tianzi
T
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China. jiangtz@nlpr.ia.ac.cn
He
Yong
Y
Zang
Yufeng
Y
Weng
Xuchu
X
D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology*; D012146:Rest / Q000502:physiology*