Salt handling and hypertension.
The kidney plays a central role in our ability to maintain appropriate sodium balance, which is critical to determination of blood pressure. In this review we outline current knowledge of renal salt handling at the molecular level, and, given that Westernized societies consume more salt than is required for normal physiology, we examine evidence that the lowering of salt intake can combat hypertension.
O'Shaughnessy
Kevin M
KM
Clinical Pharmacology Unit, University of Cambridge, UK.
Karet
Fiona E
FE
D000471:Alkalosis / Q000235:genetics; D000818:Animals; D001477:Bartter Syndrome / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D011546:Pseudohypoaldosteronism / Q000235:genetics; D012964:Sodium / Q000378:metabolism*; D012982:Sodium, Dietary / Q000008:administration & dosage*
D012982:Sodium, Dietary; D012964:Sodium