title: Axillary lymph node recurrence of papillary thyroid microcarcinoma: report of a case.
abstract: We report a case of axillary lymph node recurrence of thyroid papillary microcarcinoma (PMC) in a 51-year-old woman who had undergone thyroidectomy with lymph node dissection 5 years earlier. We performed residual thyroid resection with cervical and bilateral axillary lymph node dissection, and pathological examination revealed well-differentiated papillary carcinoma, with partial poor differentiation. Postoperative radioiodine therapy was ineffective, and the patient died of systemic dissemination of the recurrence 8 months after her second operation. The positive cell rates of proliferating cell nuclear antigen and Ki-67 were clearly higher in the recurrent lymph nodes than in the primary thyroid tumor, suggesting increased cell proliferation in the recurrent lymph nodes. Thyroid papillary carcinoma rarely recurs in the axillary lymph nodes, but its possibility must be kept in mind, especially in patients with remarkable cervical lymph node metastasis and those who undergo extensive lymph node dissection.
authors.affiliation: Department of Sugery, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Koike
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Fujii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yanaga
authors.forename: Shino
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Goro
authors.initials: G
authors.lastname: Yokoyama
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yahara
authors.forename: Mai
authors.initials: M
authors.lastname: Hanzawa
authors.forename: Seiya
authors.initials: S
authors.lastname: Kato
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D001365:Axilla; D002291:Carcinoma, Papillary / Q000556:secondary* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D012086:Reoperation; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy