title: Dose escalation or immediate full dose when switching from efavirenz to nevirapine-based highly active antiretroviral therapy in HIV-1-infected individuals?
abstract: Efavirenz induces the metabolism of co-administered drugs through the induction of CYP A4. It is often necessary to switch fron efavirenz to nevirapine because of intolerance or toxicity. In a pharmacokinetic study we determined whether to dose-escalate nevirapine or start the full dose when switching from efavirenz. It was found that when changing from efavirenz to nevirapine individuals should commence on 200 mg twice a day, as this dose is associated with therapeutic plasma drug levels.
authors.affiliation: Department of Genitourinary and HIV Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.
authors.forename: Alan
authors.initials: A
authors.lastname: Winston
authors.forename: Anton
authors.initials: A
authors.lastname: Pozniak
authors.forename: Nicola
authors.initials: N
authors.lastname: Smith
authors.forename: Carl
authors.initials: C
authors.lastname: Fletcher
authors.forename: Sundhiya
authors.initials: S
authors.lastname: Mandalia
authors.forename: Darmishta
authors.initials: D
authors.lastname: Parmar
authors.forename: Sarah
authors.initials: S
authors.lastname: Gibbons
authors.forename: David
authors.initials: D
authors.lastname: Back
authors.forename: Brian
authors.initials: B
authors.lastname: Gazzard
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D048588:Benzoxazines; D003521:Cyclopropanes; D004334:Drug Administration Schedule; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D019829:Nevirapine / Q000008:administration & dosage*; D010078:Oxazines / Q000008:administration & dosage; D019562:Viral Load
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D019829:Nevirapine; C098320:efavirenz