title: [Cervical neuroblastoma in an infant].
abstract: The case of a one-month-old patient admitted to the Department of Pediatrics (Medical and Health Science Center, Debrecen University) because of respiratory distress caused by a cervical mass compressing the upper respiratory pathways is presented. The mass could only be partially removed, the histological diagnosis proved to be neuroblastoma (SBCT: "small blue cell tumor"). Despite the fact that the DNA index of tumor cells (ploidy measurements) and the age of the patient suggested a favourable prognosis, the tumor continued to grow and metastases appeared. Because of symptoms of compression exerted on the respiratory system by the tumor, chemotherapy had to be applied. Since a standard OPEC/OJEC chemotherapeutic protocol proved to be not entirely effective and a residual tumor was still present, retinoic acid and interferon treatment was introduced. Presently, 4 years after the diagnosis, the patient is in complete remission and can be considered to be cured. The case presented here demonstrates that despite the favorable prognosis of the majority of infant neuroblastomas, in some cases the anatomic location of the tumor, leading to disturbance of vital functions, may serve as indication of chemotherapy. Our experience also proved the efficacy of retinoic acid and interferon treatment in relapsed neuroblastoma.
authors.affiliation: Gyermekklinika, Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Debrecen 4012, Hungary. arvai.k@freemail.hu
authors.forename: Krisztina
authors.initials: K
authors.lastname: Arvai
authors.forename: Judit
authors.initials: J
authors.lastname: Tóth
authors.forename: Tamás
authors.initials: T
authors.lastname: Németh
authors.forename: Csongor
authors.initials: C
authors.lastname: Kiss
authors.forename: Péter
authors.initials: P
authors.lastname: Molnár
authors.forename: Eva
authors.initials: E
authors.lastname: Oláh
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005819:Genetic Markers; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D006801:Humans; D007223:Infant; D009333:Neck; D009447:Neuroblastoma / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers