In vivo measurement of phosphorous markers of disease.
Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) has been utilized to study energy, carbohydrate, and phospholipid metabolism in vitro and in vivo in live tissues non-invasively. Despite its lack of sensitivity, its application has extended to in situ human tissues and organs since proper signal localization was devised. Follow-up of phosphocreatine in neuromuscular diseases and schizophrenia and follow-up of phospholipid-related molecules in tumors are described here to demonstrate the value of 31P-MRS as an imaging technique to determine in vivo markers of disease and in the diagnosis, prognosis, and follow-up of human diseases.
Arias-Mendoza
Fernando
F
Hatch Center for MR Research, Department of Radiology, Columbia University, New York, NY 10032, USA. fa2003@columbia.edu
Brown
Truman R
TR
D014408:Biomarkers, Tumor; D055592:Biophysical Phenomena; D001703:Biophysics; D001921:Brain / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008223:Lymphoma / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009369:Neoplasms / Q000473:pathology; D009468:Neuromuscular Diseases / Q000473:pathology; D010725:Phosphocreatine / Q000737:chemistry; D010758:Phosphorus / Q000737:chemistry*; D011379:Prognosis; D011522:Protons; D012559:Schizophrenia / Q000473:pathology; D013997:Time Factors
D014408:Biomarkers, Tumor; D011522:Protons; D010725:Phosphocreatine; D010758:Phosphorus