title: Application of glycodiversification: expedient synthesis and antibacterial evaluation of a library of kanamycin B analogues.
abstract: [reaction: see text] The expedient synthesis of a library of kanamycin B analogues is reported. The revealed SAR will guide future designs in developing kanamycin-type aminoglycoside antibiotics against drug-resistant bacteria.
authors.affiliation: Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Jinhua
authors.initials: J
authors.lastname: Wang
authors.forename: Przemyslaw Greg
authors.initials: PG
authors.lastname: Czyryca
authors.forename: Huiwen
authors.initials: H
authors.lastname: Chang
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Orsak
authors.forename: Richard
authors.initials: R
authors.lastname: Evanson
authors.forename: Cheng-Wei Tom
authors.initials: CW
authors.lastname: Chang
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects; D007612:Kanamycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012336:RNA, Ribosomal, 16S / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D012336:RNA, Ribosomal, 16S; C001495:bekanamycin; D007612:Kanamycin