[Hepatoprotective effects of amino acids with branched hydrocarbon chains and taurine in experimental subchronic alcohol intoxication and ethanol withdrawal].
Forced alcoholization of rats according to Majchrowicz led to the development of fatty liver. The subsequent ethanol withdrawal was accompanied by amino acid imbalance in the pool of free sulfur-containing and glycogenic amino acids in liver and blood plasma. Similar changes were observed after prolonged alcohol intoxication. Intragastric administration of the amino acid composition containing branched-chain amino acids and taurine corrected the amino acid imbalance and reduced the development of the steatosis of the liver.
Razvodovskiĭ
Iu E
IuE
Institute of Biochemistry, National Academy of Sciences, Grodno, Belarus.
Doroshenko
E M
EM
Prokopchik
N I
NI
Smirnov
V Iu
VIu
Ostrovskiĭ
S Iu
SIu
D000435:Alcoholic Intoxication / Q000150:complications*; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D000818:Animals; D000431:Ethanol / Q000009:adverse effects*; D005234:Fatty Liver / Q000209:etiology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000150:complications*; D013654:Taurine / Q000627:therapeutic use*
D000596:Amino Acids; D013654:Taurine; D000431:Ethanol