[Results and surgical complications of pancreas transplantation with enteric exocrine drainage].
BACKGROUND
The objective of this study was to evaluate the results and surgical complications of total pancreas transplantation with enteric exocrine drainage since the beginning of our experience with this type of transplantation.


METHODS
From November 1999 to December 2002, 62 total pancreas transplantations were performed, consisting of 51 combined kidney-pancreas transplantations, 10 after renal transplantation and 1 pancreas-liver transplantation. Kidneys and pancreases were washed and stored in either Belzer solution or Celsior solution. Transplantation was performed via a midline transperitoneal incision with venous anastomosis at the root of the inferior vena cava (54 cases) or, more recently, in the superior mesenteric vein (8 cases). The arterial anastomosis was then performed in the right common iliac artery. Exocrine drainage was performed by side-to-side anastomosis between the donor duodenum and the recipient jejunum. The kidney was transplanted onto the left external iliac vessels and was extraperitonealised.


RESULTS
The mean age of the recipients and donors was 41 +/- 9 years and 33 +/- 11 years, respectively. The mean cold ischaemia time was 14 +/- 5 hours. Four pancreases were lost due to venous thrombosis, 1 due to severe pancreatitis with haemodynamic collapse and venous thrombosis and another due to total necrosis of the duodenum. Seventeen patients (27%) were reoperated, including 10 during the first postoperative month and 7 during the first year. No cases of fistula of the gastrointestinal anastomosis were observed. All patients with a functional graft no longer required exogenous insulin. The actuarial patient and graft three-year survival was 96% and 86% respectively.


CONCLUSIONS
Despite their high frequency, surgical complications did not have any harmful effects on either control of diabetes or graft and patient survival.
Karam
Georges
G
Clinique Urologique, CHU Hôtel-Dieu, Nantes, France. gkaram@chu-nantes.fr
Maillet
Frédéric
F
Le Normand
Loïc
L
Glemain
Pascal
P
Drapier
Eric
E
Bouchot
Olivier
O
Cantarovich
Diego
D
D000328:Adult; D004322:Drainage / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D016035:Pancreas Transplantation / Q000009:adverse effects* / Q000379:methods*; D012189:Retrospective Studies