title: Differential desensitization of somatostatin receptor subtypes in atT-20 cells.
abstract: Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.
authors.affiliation: Department of Biology, Seton Hall University, South Orange, NJ 07079, USA.
authors.forename: Fredric C
authors.initials: FC
authors.lastname: Mazza
authors.forename: Allan D
authors.initials: AD
authors.lastname: Blake
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D051379:Mice; D017481:Receptors, Somatostatin / Q000819:agonists / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D017481:Receptors, Somatostatin; D005576:Colforsin; D013004:Somatostatin; D000242:Cyclic AMP