Hemodynamics of carotid artery atherosclerotic occlusive disease.
Hemodynamic mechanisms for the initiation and progression of carotid bifurcation atherosclerotic occlusive disease have been extensively researched during the past few decades. Attention has focused on the carotid bulb, or sinus, where most atherosclerotic plaques are found. Herein, the authors review the seminal works that have led to an understanding of not only complex local hemodynamics but also the elicited specific biologic response. In addition, new analysis of the age-dependent morphologic maturation of the human carotid bifurcation is unveiled. Understanding the role of hemodynamics in atherogenesis may lead to the improvement of minimally invasive endovascular therapy and noninvasive strategies.
Wakhloo
Ajay K
AK
Department of Radiology, School of Medicine, University of Miami, 1611 Northwest 12th Avenue, West Wing 279, Miami, FL 33136, USA. awakhloo@med.miami.edu
Lieber
Baruch B
BB
Seong
Jaehoon
J
Sadasivan
Chander
C
Gounis
Matthew J
MJ
Miskolczi
Laszlo
L
Sandhu
Johnny S
JS
D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D017536:Carotid Artery, Common / Q000473:pathology* / Q000503:physiopathology*; D016893:Carotid Stenosis / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D012039:Regional Blood Flow / Q000502:physiology; D020521:Stroke / Q000209:etiology / Q000503:physiopathology; D014481:United States / Q000453:epidemiology