title: Lipid profile in women over 35 years old using triphasic combined oral contraceptives.
abstract: Twenty-nine women aged 35 years old or more, using triphasic combined oral contraceptive (COC) were evaluated during six cycles for the following parameters: total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and its subfraction HDL2, triglycerides, apoproteins A and B, Castelli risk index I and II (cholesterol/HDL-C and LDL-C/HDL-C) and apoprotein ratio (apoprotein B/apoprotein A). The same laboratory measurements were done in a control group of 49 non-COC-user women. The results showed that there were no differences on most of the studied parameters between user and nonuser women. There was a significant reduction of HDL-C and HDL2-C, although within the normal range. In addition, it was observed a significant increment of triglycerides and apoprotein B at 6 months of follow-up only in user group (p < 0.05), although within the normal range. It is concluded that the use of levonorgestrel triphasic COC appeared to have no additional adverse impact when used by women aged over 35 years. Further studies are needed to obtain conclusive data.
authors.affiliation: Department of Maternal Health, School of Public Health, University of São Paulo, São Paulo, Brazil. jmaldri@usp.br
authors.forename: José Mendes
authors.initials: JM
authors.lastname: Aldrighi
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Petta
authors.forename: Luis
authors.initials: L
authors.lastname: Bahamondes
authors.forename: Maria Eugenia
authors.initials: ME
authors.lastname: Caetano
authors.forename: Tânia Regina Leme
authors.initials: TR
authors.lastname: Martinez
authors.forename: Geraldo Rodrigues
authors.initials: GR
authors.lastname: De Lima
mesh_terms: D000328:Adult; D001059:Apoproteins / Q000097:blood / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000494:pharmacology; D008055:Lipids / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D001059:Apoproteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D014280:Triglycerides; D004997:Ethinyl Estradiol; D016912:Levonorgestrel