title: Effect of carotid endarterectomy or stenting on impairment of dynamic cerebral autoregulation.
abstract: OBJECTIVE
  Analysis of dynamic cerebral autoregulation (DCA) from spontaneous blood pressure fluctuations might contribute to prognosis of severe internal carotid artery stenosis, but its response to carotid recanalization has not been investigated so far. This study investigates the effect of carotid endarterectomy or stenting on various DCA parameters.
  
  
  METHODS
  In 58 patients with severe unilateral stenosis undergoing carotid endarterectomy (n=41) or stenting (n=17), cerebral blood flow velocity (CBFV, transcranial Doppler) and arterial blood pressure (ABP, Finapres method) were recorded over 10 minutes before and on average 3 days after carotid recanalization. Nineteen patients were additionally examined after 7 months. Correlations between diastolic and mean ABP and CBFV fluctuations were averaged to form the correlation coefficient indices (diastolic [Dx] and mean values [Mx]). Transfer function parameters (low-frequency phase and high-frequency gain between ABP and CBFV oscillations) were calculated over the same 10 minutes. CO2 reactivity was assessed via inhalation of 7% CO2.
  
  
  RESULTS
  Before recanalization, all DCA parameters were clearly impaired ipsilaterally compared with contralateral sides. Phase, Dx, and Mx indicated early normalization of DCA after both endarterectomy and stenting. By multiple regression, the degree of DCA improvement was highly significantly related to the extent of impairment before recanalization. No significant change in DCA was found at follow-up. Ipsilateral gain and CO2 reactivity increased significantly less after endarterectomy than after stenting (P<0.05).
  
  
  CONCLUSIONS
  Dynamic cerebral dysautoregulation in patients with severe carotid obstruction is readily and completely remedied by carotid recanalization.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, University of Freiburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Reinhard
authors.forename: M
authors.initials: M
authors.lastname: Roth
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Guschlbauer
authors.forename: J
authors.initials: J
authors.lastname: Timmer
authors.forename: M
authors.initials: M
authors.lastname: Czosnyka
authors.forename: A
authors.initials: A
authors.lastname: Hetzel
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D016893:Carotid Stenosis / Q000503:physiopathology / Q000601:surgery*; D002540:Cerebral Cortex / Q000098:blood supply*; D016894:Endarterectomy, Carotid; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents