Do metastases metastasize?
Metastatic disease is a major cause of morbidity and mortality. However, it is not clear if all metastases originate from the primary tumour or whether metastases themselves have the capacity to metastasize. In this review, the evidence for the latter phenomenon, and its biological and clinical implications, is discussed.
Tait
Catherine R
CR
Department of Surgery, The General Infirmary at Leeds, Great George Street, Leeds, West Yorkshire LS1 3EX, UK. cathytait@doctors.org.uk
Dodwell
D
D
Horgan
K
K
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology*; D013997:Time Factors