Olfaction differentiates parkin disease from early-onset parkinsonism and Parkinson disease.
The authors studied whether olfactory dysfunction is present in parkin disease using the University of Pennsylvania Smell Identification Test (UPSIT). The mean UPSIT score in parkin patients was 27.3 (95% CI 24.4 to 30.2). This did not differ from the normal group mean of 29.4 (95% CI 28.0 to 30.7; p = 0.22) but was higher than the Parkinson disease group (mean 14.3; 95% CI 12.2 to 19.5; p < 0.0001) and the parkin-negative group (mean 17.1; 95% CI 14.8 to 16.3; p < 0.0001) values. Parkin disease may be a distinct and separate entity from Parkinson disease.
Khan
N L
NL
Department of Molecular Neurosciences, Institute of Neurology, London School of Hygiene and Tropical Medicine, University College London, UK.
Katzenschlager
R
R
Watt
H
H
Bhatia
K P
KP
Wood
N W
NW
Quinn
N
N
Lees
A J
AJ
D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000857:Olfaction Disorders / Q000175:diagnosis* / Q000453:epidemiology; D010300:Parkinson Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D011237:Predictive Value of Tests; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D006113:United Kingdom / Q000453:epidemiology
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein