title: Evaluation of the phagocytic activity of peripheral blood monocytes of patients with Jorge Lobo's disease.
abstract: Studies on host-parasite interaction in Jorge Lobo's disease are scarce, with no report in the literature on the phagocytosis of Lacazia loboi by phagocytic mononuclear cells. Thus, the objective of the present study was to assess the phagocytic activity of blood monocytes in the presence of L. loboi in patients with the disease and in healthy subjects (controls) over 3 and 24 hours of incubation. Statistical analyses of the results showed no significant difference in percent phagocytosis of the fungus between patient and control monocytes. With respect to incubation time, however, there was a significant difference, in that percent phagocytosis was higher at 3 hours than at 24 hours (p <0.01). These results suggest that monocytes from patients with the mycosis are able to phagocyte the fungus, as also observed in control individuals.
authors.affiliation: Equipe Técnica de Imunologia, Instituto Lauro de Souza Lima, Bauru, SP, Brazil. imunologia@ilsl.br
authors.forename: Fátima Regina
authors.initials: FR
authors.lastname: Vilani-Moreno
authors.forename: Luciana Moreira
authors.initials: LM
authors.lastname: Silva
authors.forename: Diltor Vladimir Araújo
authors.initials: DV
authors.lastname: Opromolla
mesh_terms: D000704:Analysis of Variance; D016022:Case-Control Studies; D003881:Dermatomycoses / Q000097:blood*; D005658:Fungi; D006801:Humans; D009000:Monocytes / Q000382:microbiology / Q000502:physiology*; D010587:Phagocytosis / Q000502:physiology*; D013997:Time Factors