title: Immunohistochemical detection of phosphorylated form of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei following hemorrhagic hypotension.
abstract: The purpose of this study was to evaluate the expression of the phosphorylated form of extracellular-regulated protein kinase 1/2 (pERK1/2), which is one of the major regulatory factors for transcription of the c-fos oncogene in neurons, within the vestibular nuclei (VN) of rats following acute arterial hypotension. Following acute arterial hypotension induced by rapid hemorrhage, a significant number of pERK1/2-immunoreactive neurons appeared bilaterally in the caudal aspect of the medial and inferior VN. No labeling of pERK1/2 was observed in the lateral VN. The peak expression of pERK1/2-immunoreactive neurons in these nuclei occurred within 5 min after hemorrhage. In bilaterally labyrinthectomized rats, the appearance of pERK1/2-immunoreactive neurons was eliminated in the VN. These results suggest that, following acute hypotension, afferent signals from the peripheral vestibular receptors are required for activation of extracellular signal-regulated kinase 1/2 in the VN.
authors.affiliation: Department of Physiology, Wonkwang University School of Medicine and Vestibulocochlear Research Center at Wonkwang University, Iksan 570-749, South Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Choi
authors.forename: Myoung Ae
authors.initials: MA
authors.lastname: Choi
authors.forename: Jae Hyo
authors.initials: JH
authors.lastname: Kim
authors.forename: Kwang Yong
authors.initials: KY
authors.lastname: Kim
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Jeong Kun
authors.initials: JK
authors.lastname: Rhee
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Chun
authors.forename: Byung Rim
authors.initials: BR
authors.lastname: Park
mesh_terms: D000818:Animals; D004789:Enzyme Activation / Q000502:physiology; D006470:Hemorrhage / Q000201:enzymology*; D007022:Hypotension / Q000201:enzymology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000032:analysis / Q000096:biosynthesis*; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000032:analysis / Q000096:biosynthesis; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014726:Vestibular Nuclei / Q000737:chemistry / Q000201:enzymology*
chemical_list: D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases