title: The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases.
abstract: Interleukin 10 (IL-10) is a key cytokine produced by a multitude of immune effector cells and possesses distinct regulatory effects on immune functioning in the skin. In this article we report the current understanding of the immunobiology of IL-10 and identify the role of IL-10 in cutaneous infection as well as in autoimmune and neoplastic processes. We reviewed the literature to examine the function of IL-10 in different cutaneous disorders. IL-10 can influence and potentially treat T1/T2 differentiation, antigen-presenting cell functioning, antigen-presenting cell-mediated T-cell activation, and T-cell, B-cell, and mast cell growth and differentiation that is aberrant in various disease processes. The literature consensus is that the multitude of effects of IL-10 contribute to the pathogenesis of different skin disorders. In certain circumstances IL-10 could represent novel therapeutic approaches to treating cutaneous diseases.
  
  
  OBJECTIVE
  At the conclusion of this learning activity, participants should be acquainted with the role of IL-10 in many infectious diseases, autoimmune skin disease, inflammatory processes, and malignancy. Its possible role in the resolution of various skin diseases should be better understood.
authors.affiliation: Department of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: Elliot
authors.initials: E
authors.lastname: Weiss
authors.forename: Adam Joseph
authors.initials: AJ
authors.lastname: Mamelak
authors.forename: Stephania
authors.initials: S
authors.lastname: La Morgia
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
authors.forename: Claudio
authors.initials: C
authors.lastname: Feliciani
authors.forename: Antonio
authors.initials: A
authors.lastname: Tulli
authors.forename: Daniel Nathan
authors.initials: DN
authors.lastname: Sauder
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D003872:Dermatitis / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology; D012867:Skin / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D012874:Skin Diseases, Infectious / Q000276:immunology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000276:immunology / Q000503:physiopathology
chemical_list: D016753:Interleukin-10