title: Kinetics of degradation of cefetamet pivaloyloxymethyl ester and its hydrochloride in solid phase.
abstract: The influence of temperature and relative humidity on the stability of cefetamet pivoxil (CFP) and its hydrochloride (CFP.HCl) in solid phase was investigated. The process of degradation was studied using HPLC with UV detection. The degradation of CFP and CFP.HCl occurring at air humidity RH>50% is an autocatalytic first-order reaction with respect to substrate concentration, while at 0% relative humidity of the ambient air it is a first-order reaction relative to substrate concentration for CFP.HCl, and a reversible first-order reaction for CFP. The rate constants (k) were determined in dry air at 373 K, 378 K, 383 K, 388 K and 393 K; at air humidity RH = 76.4% at 333 K, .343 K, 353 K, 363 K and 373 K; and at 363 K at air humidity RH>50%. The kinetic and thermodynamic parameters of the degradation were calculated.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medical Sciences 6 Grunwaldzka Str., 60-780 Poznań, Poland. ajelinsk@amp.edu.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Jelińska
authors.forename: Marianna
authors.initials: M
authors.lastname: Zajac
authors.forename: Leszek
authors.initials: L
authors.lastname: Dobrowolski
authors.forename: Beata
authors.initials: B
authors.lastname: Medenecka
authors.forename: Piotr
authors.initials: P
authors.lastname: Ruciński
authors.forename: Irena
authors.initials: I
authors.lastname: Oszczapowicz
mesh_terms: D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*; D010599:Pharmacokinetics
chemical_list: D015296:Ceftizoxime; C047445:cefetamet pivoxyl