Kinetics of degradation of cefetamet pivaloyloxymethyl ester and its hydrochloride in solid phase.
The influence of temperature and relative humidity on the stability of cefetamet pivoxil (CFP) and its hydrochloride (CFP.HCl) in solid phase was investigated. The process of degradation was studied using HPLC with UV detection. The degradation of CFP and CFP.HCl occurring at air humidity RH>50% is an autocatalytic first-order reaction with respect to substrate concentration, while at 0% relative humidity of the ambient air it is a first-order reaction relative to substrate concentration for CFP.HCl, and a reversible first-order reaction for CFP. The rate constants (k) were determined in dry air at 373 K, 378 K, 383 K, 388 K and 393 K; at air humidity RH = 76.4% at 333 K, .343 K, 353 K, 363 K and 373 K; and at 363 K at air humidity RH>50%. The kinetic and thermodynamic parameters of the degradation were calculated.
Jelińska
Anna
A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medical Sciences 6 Grunwaldzka Str., 60-780 Poznań, Poland. ajelinsk@amp.edu.pl
Zajac
Marianna
M
Dobrowolski
Leszek
L
Medenecka
Beata
B
Ruciński
Piotr
P
Oszczapowicz
Irena
I
D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics*; D010599:Pharmacokinetics
D015296:Ceftizoxime; C047445:cefetamet pivoxyl