High-resolution functional optical imaging: from the neocortex to the eye.
Much work remains to be done to establish the clinical usefulness of the RFI for early diagnosis and treatment guidance. The discoveries obtained by functional optical imaging of the neocortex in the last 15 years and the recent RFI studies of the eyes of normal subjects and patients with diabetic retinopathy, glaucoma, and age-related macular degeneration suggest that functional optical imaging of the retina is likely to become a multi-modality powerful clinical tool.
Grinvald
Amiram
A
Department of Neurobiology, The Weizmann Institute of Science, The Grodetsky Center for Research of Higher Brain Functions, Rehovot, Israel. Amiram.Grinvald@weizmann.weizmann.ac.il
Bonhoeffer
Tobias
T
Vanzetta
Ivo
I
Pollack
Ayala
A
Aloni
Eyal
E
Ofri
Ron
R
Nelson
Darin
D
D000818:Animals; D001931:Brain Mapping; D003952:Diagnostic Imaging / Q000295:instrumentation; D004867:Equipment Design; D006801:Humans; D019579:Neocortex / Q000033:anatomy & histology* / Q000098:blood supply / Q000502:physiology*; D055095:Optics and Photonics / Q000295:instrumentation; D010092:Oximetry / Q000379:methods; D012039:Regional Blood Flow; D012160:Retina / Q000033:anatomy & histology*; D012171:Retinal Vessels / Q000033:anatomy & histology / Q000502:physiology*