A pilot randomized, double-blind, placebo-controlled study of granisetron in the treatment of sexual dysfunction in women associated with antidepressant use.
A pilot study was conducted to evaluate the usefulness of granisetron for the treatment of antidepressant induced sexual dysfunction in women. Twelve women with antidepressant induced sexual dysfunction (AISD) were assigned granisetron (n=5) or placebo (n=7) in a 14-day randomized, double-blind, placebo-controlled study. One participant in the granisetron group did not complete the study. Participants were assessed at baseline, day 7 and day 14 using the Feiger Sexual Function and Satisfaction Questionnaire and the Arizona Sexual Experience Scale. No statistical differences were measured at baseline or at endpoint between the granisetron or placebo group. This study did not produce evidence supporting the usefulness of granisetron in AISD.
Jespersen
Sean
S
Department of Psychiatry, University of Witwatersrand Medical School, Parktown, South Africa.
Berk
Michael
M
Van Wyk
Caren
C
Dean
Olivia
O
Dodd
Seetal
S
Szabo
Christopher P
CP
Maud
Catherine
C
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D017829:Granisetron / Q000627:therapeutic use*; D006801:Humans; D010865:Pilot Projects; D012702:Serotonin Antagonists / Q000627:therapeutic use*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D011795:Surveys and Questionnaires
D000928:Antidepressive Agents; D017829:Granisetron; D012702:Serotonin Antagonists