Binding of 9-methylguanine to [cis-Ru(2,2'-bpy)2]2+: First X-ray structure of a cis-bis purine complex of ruthenium.
Reaction of [cis-Ru(2,2'-bpy)2(O3SCF3)2] (1) with 9-methylguanine (9-MeG) affords the cis-[Ru(2,2'-bpy)2(9-MeG)2]2+ complex (2) in good yield. Two bases bind to the metal center via the N7 atoms. X-ray structure analysis of 2(SO3CF3)2 (monoclinic, P2(1)/n, a = 12.5159(6) A, b = 20.0904(13) A, c = 17.1202(9) A, beta = 98.981(6) degrees, V = 4252.1(4) A(3), Z = 4) reveals that the two bases are in a head-to-tail (HT) orientation with base-base dihedral angle of 60.4 degrees. NMR studies confirm that the complex is stable in water for hours, and no evidence for guanine substitution by solvent molecules was found.
Zobi
Fabio
F
Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Hohl
Michael
M
Zimmermann
Iwan
I
Alberto
Roger
R
D018360:Crystallography, X-Ray; D006147:Guanine / Q000031:analogs & derivatives* / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009942:Organometallic Compounds / Q000138:chemical synthesis*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; C116701:9-methylguanine; D006147:Guanine; D012428:Ruthenium