title: Gastric myeloid metaplasia: a case report and review of the literature.
abstract: We report a case of gastric myeloid metaplasia in an 89- year-old woman with agnogenic myeloid metaplasia. The lesions were fortuitously discovered on upper endoscopy. The antral mucosa was thickened and polypoid, and on histologic examination contained immature granulocytes, megakaryocytes, and a few erythroblasts without desmoplastic stromal reaction. The granulocytes were positive for CD15, CD68, and myeloperoxidase on immunohistochemistry, and the megakaryocytes showed positive reactivity for factor VIII. Gastric myeloid metaplasia is a very rare event, and to our knowledge only 6 cases have been reported in the literature to date. It usually occurs in patients with advanced myeloproliferative syndrome. Gastric myeloid metaplasia often has a pseudotumoral appearance, leading to digestive symptoms. Histologic diagnosis is straightforward when trilinear hematopoietic elements are identified in gastric biopsies. Immunohistochemistry with anti-factor VIII antibody can be useful to confirm the presence of megakaryocytes.
authors.affiliation: Department of Pathology, Centre Hospitalo-Universitaire Amiens, Amiens, France. Chatelain.denis@chu-amiens.fr
authors.forename: Denis
authors.initials: D
authors.lastname: Chatelain
authors.forename: Agnès
authors.initials: A
authors.lastname: Devendeville
authors.forename: Alain
authors.initials: A
authors.lastname: Rudelli
authors.forename: Alexis
authors.initials: A
authors.lastname: Bruniau
authors.forename: Guillaume
authors.initials: G
authors.lastname: Geslin
authors.forename: Henri
authors.initials: H
authors.lastname: Sevestre
mesh_terms: D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D055728:Primary Myelofibrosis / Q000175:diagnosis / Q000473:pathology*