title: Approaches to transplantation tolerance in humans.
abstract: Although transplantation tolerance to organ allografts has been achieved using a wide variety of immunologic interventions in laboratory animals, few tolerance induction protocols with complete immunosuppressive drug withdrawal have been tested in humans. Preclinical and clinical studies of the use of total lymphoid irradiation for the induction of chimeric and nonchimeric tolerance are summarized here.
authors.affiliation: Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305-5166, USA. sstrober@stanford.edu
authors.forename: Samuel
authors.initials: S
authors.lastname: Strober
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Lowsky
authors.forename: Judith A
authors.initials: JA
authors.lastname: Shizuru
authors.forename: John D
authors.initials: JD
authors.lastname: Scandling
authors.forename: Maria T
authors.initials: MT
authors.lastname: Millan
mesh_terms: D000818:Animals; D006650:Histocompatibility Testing; D006801:Humans; D018183:Transplantation Chimera; D023001:Transplantation Tolerance / Q000276:immunology