The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study.
It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.
Slooter
A J C
AJ
Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
Cruts
M
M
Hofman
A
A
Koudstaal
P J
PJ
van der Kuip
D
D
de Ridder
M A J
MA
Witteman
J C M
JC
Breteler
M M B
MM
Van Broeckhoven
C
C
van Duijn
C M
CM
D017677:Age Distribution; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D016016:Proportional Hazards Models; D012306:Risk; D018570:Risk Assessment; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics
D001057:Apolipoproteins E