title: Utility of base deficit, lactic acid, microalbuminuria, and C-reactive protein in the early detection of complications in the immediate postoperative evolution.
abstract: OBJECTIVE
  To determine the utility of biochemical parameters such as lactic acid (LA), C-reactive protein (CRP), microalbuminuria (MAU), and base deficit (BD) as early markers of complications in the immediate postoperative evolution of elective open gastrointestinal surgeries.
  
  
  METHODS
  Sixty-two patients subject to elective open gastrointestinal surgery were evaluated during a period of 22 months.
  
  
  RESULTS
  From the initial 62 patients, 2 were excluded, 29 (48.3%) evolved without complications, and 31 (51.6%) with complications. It was observed that the most significant areas under the ROC curve corresponded to BD in the preoperative period, LA on the first day, and CRP from the second to the seventh day after surgery. MAU was not a discriminating parameter since it did not reach a significant area under the curve (AUC) at any time.
  
  
  CONCLUSIONS
  The biochemical markers that best relate to the presence of complications are BD in the preoperative period, LA on the first day, and CRP from the second to the seventh day after surgery.
authors.affiliation: Servicio de Cirugía General, Hospital General de Agudos Dr Cosme Argerich, Gobierno de la Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Bianchi
authors.forename: Nydia A
authors.initials: NA
authors.lastname: Silva
authors.forename: Marcela L
authors.initials: ML
authors.lastname: Natal
authors.forename: María C
authors.initials: MC
authors.lastname: Romero
mesh_terms: D000137:Acid-Base Imbalance / Q000097:blood; D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood; D001118:Argentina; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D003404:Creatinine / Q000652:urine; D013505:Digestive System Surgical Procedures; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood; D011184:Postoperative Period; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D019344:Lactic Acid; D002097:C-Reactive Protein; D003404:Creatinine