New cytotoxic metabolites from a marine sponge Homaxinella sp.
Three new butenolides (1-3), a new cyclopentenone derivative (4), and a known alcohol (5) were isolated from a marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analyses. The stereochemistry of the butenolides and cyclopentenone derivative was defined on the basis of optical rotation and CD spectroscopy. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed marginal to significant activity.
Mansoor
Tayyab A
TA
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Hong
Jongki
J
Lee
Chong-O
CO
Sim
Chung Ja
CJ
Im
Kwang Sik
KS
Lee
Dong Seok
DS
Jung
Jee H
JH
D000438:Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D003517:Cyclopentanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007723:Korea; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
C486280:(2Z,5Z,8Z)-tetradeca-2,5,8-trien-1-ol; D000438:Alcohols; D000970:Antineoplastic Agents; D003517:Cyclopentanes; D005663:Furans; C486275:homaxinolide A; C486277:homaxinolide B; C486278:homaxinolide C; C486279:homaxinone A