title: Pericarditis associated with Epstein-Barr virus reactivation in a patient following allogeneic peripheral blood stem cell transplantation from an HLA genotypic 1-locus mismatched sibling donor.
abstract: A 31-year-old woman with acute myeloblastic leukemia (AML) underwent allogeneic peripheral blood stem cell transplant (PBSCT). On day +274 following transplantation, the patient had severe chest pain, high-grade fever, and general fatigue. Electrocardiographic examination revealed ST segment elevation, and echocardiographic examination revealed an obvious pericardial. The diagnosis of pericarditis was made. We could not exclude the possibility of a combination of chronic GVHD involving the liver, because biochemistry examination revealed altered liver dysfunction, but liver biopsy was not performed. The patient underwent empirical treatment for bacterial or viral infection, and was given prednisolone for chronic GVHD. Retrospective serologic examination revealed that EBV reactivation had occurred at this time. This is the first reported case of pericarditis associated with EBV reactivation after allogeneic-stem cell transplantation (allo-SCT).
authors.affiliation: Department of Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Osaka, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakao
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ohta
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sakai
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Ryousuke
authors.initials: R
authors.lastname: Yamamura
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000328:Adult; D004562:Electrocardiography; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008099:Liver / Q000473:pathology; D010493:Pericarditis / Q000175:diagnosis* / Q000628:therapy / Q000821:virology*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods*; D011239:Prednisolone / Q000627:therapeutic use; D035781:Siblings; D013997:Time Factors; D014184:Transplantation, Homologous / Q000379:methods*
chemical_list: D011239:Prednisolone