Altered Na+-K+ ATPase immunoreactivity within GABAergic neurons in the gerbil hippocampal complex induced by spontaneous seizure and vigabatrin treatment.
In the present study, the expression of Na(+)-K(+) ATPase in the gerbil hippocampus associated with various sequelae of spontaneous seizures were investigated in order to identify the roles of Na(+)-K(+) ATPase in the epileptogenesis and the recovery mechanisms in these animals. The population of Na(+)-K(+) ATPase immunoreactive neurons and Na(+)-K(+) ATPase immunodensity were significantly lower in the pre-seizure group of SS gerbils than those in SR gerbils. At 30-min postictal, the Na(+)-K(+) ATPase immunoreactivity was significantly elevated in the hippocampal complex. At 3-h postictal, the Na(+)-K(+) ATPase immunoreactivity in the hippocampus was declined, as compared to the 30-min postictal. At 12h after seizure on-set, Na(+)-K(+) ATPase expression was re-enhanced in the all regions of the hippocampal complex including the dentate hilus. Following administration of vigabatrin Na(+)-K(+) ATPase expression was also increased. The present data suggest that altered Na(+)-K(+) ATPase expression may contribute the regulation of the seizure activity in this animal.
Kang
Tae-Cheon
TC
Department of Anatomy, College of Medicine, Hallym University, Kangwon-Do, Chunchon 200-702, South Korea. tckang@hallym.ac.kr
Park
Seung-Kook
SK
Hwang
In-Koo
IK
An
Sung-Jin
SJ
Won
Moo Ho
MH
D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology*; D009474:Neurons / Q000737:chemistry / Q000187:drug effects / Q000201:enzymology; D012640:Seizures / Q000188:drug therapy / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis / Q000378:metabolism*; D020888:Vigabatrin / Q000494:pharmacology / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000032:analysis / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D000254:Sodium-Potassium-Exchanging ATPase; D020888:Vigabatrin