title: HIV infection: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment.
abstract: Highly active antiretroviral therapy (HAART) in HIV patients generally increases the CD4 cell count, but the level of CD4 cell restoration remains very heterogeneous. IL-7 is the main cytokine controlling the size of the T-cell pool. We assessed the hypothesis that pre-HAART IL-7 plasma levels may affect CD4 cell restoration after treatment. A positive correlation was found in a cohort of 18 patients between pre-HAART IL-7 plasma levels and CD4 cell increases after 20 +/- 7.8 months of HAART.
authors.affiliation: Unité d'ImmunoGénétique Cellulaire, Institut Pasteur, Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Beq
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Rannou
authors.forename: Arnaud
authors.initials: A
authors.lastname: Fontanet
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Delfraissy
authors.forename: Jacques
authors.initials: J
authors.lastname: Thèze
authors.forename: Jean-Hervé
authors.initials: JH
authors.lastname: Colle
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D015851:Interleukin-7 / Q000097:blood*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D015851:Interleukin-7