[Influence of cultivation conditions on the antibiotic activity in "Pseudomonas batumici"--batumin producer].
The optimum parameters of cultivation of "Pseudomonas batumici"--a producer of antistaphylococcal antibiotic batumin has been established. The periodical process of culture development and antibiotic synthesis has been studied. Conditions of batumin biosynthesis are the temperature 23-25 degrees C, aeration 0.55-0.65 g O2/l.h and neutral pH of the medium. Probably batumin is not the secondary metabolite, because its synthesis begins in the culture exponential growth phase and continues in parallel with it.
Klochko
V V
VV
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.
Kiprianova
O A
OA
Smirnov
V V
VV
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D006863:Hydrogen-Ion Concentration; D009930:Organic Chemicals; D010100:Oxygen; D011549:Pseudomonas / Q000254:growth & development* / Q000378:metabolism; D013696:Temperature
D000900:Anti-Bacterial Agents; D009930:Organic Chemicals; C088306:batumin; D010100:Oxygen