title: [Gln192Arg polymorphism of the paraoxonase-1 gene is not associated with Alzheimer's disease in Chinese].
abstract: OBJECTIVE
  To explore the relationship between paraoxonase-1 (PON1) gene Gln192Arg polymorphism and sporadic Alzheimer's disease (AD) in Chinese.
  
  
  METHODS
  A total of 165 AD patients and 174 age-matched control subjects were enrolled in this study for examination of PON1 Gln192Arg and apolipoprotein E gene polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The distribution of PON1 allelic and genotypic frequencies did not significantly differ between AD patients and the control subjects, even after the stratification by ApoE-epsilon4 status.
  
  
  CONCLUSIONS
  Gln192Arg polymorphism of the PON1 gene is not associated with sporadic AD in Chinese.
authors.affiliation: Department of Medical Genetics and Division of Human Morbid Genomics, Key Laboratory of Biotherapy of Human Diseases of the Ministry of Education, West China Hospital, Sichuan University, Chengdu 610041, China. shiand98@21cn.com
authors.forename: Jia-jun
authors.initials: JJ
authors.lastname: Shi
authors.forename: Si-zhong
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Cui
authors.initials: C
authors.lastname: Ma
authors.forename: Mou-ni
authors.initials: MN
authors.lastname: Tang
authors.forename: Xie-he
authors.initials: XH
authors.lastname: Liu
authors.forename: Ying-cheng
authors.initials: YC
authors.lastname: Wang
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Han
authors.forename: Yang-bo
authors.initials: YB
authors.lastname: Guo
authors.forename: Rong-mei
authors.initials: RM
authors.lastname: Feng
authors.forename: Guo-dong
authors.initials: GD
authors.lastname: Miao
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human