title: 2,3-diarylpyran-4-ones: a new series of selective cyclooxygenase-2 inhibitors.
abstract: A new series of cyclooxygenase-2 (COX-2) inhibitors with gamma-pyrone as central scaffold unit has been synthesized and their biological activities were evaluated against cyclooxygenase inhibitory activity. The changes of physical properties of the molecules were performed according to the medicinal chemistry principles and moderate oral anti-inflammatory activity was obtained with this series of inhibitors.
authors.affiliation: Drug Discovery, AmorePacific Corporation R&D Center, Pharmaceutical & Health Research Institute, 314-1 Bora-ri, Kiheung-eup, Yongin-si, Kyounggi-do 449-729, South Korea. yhjoo@amorepacific.com
authors.forename: Yung
authors.initials: Y
authors.lastname: Hyup Joo
authors.forename: Jin
authors.initials: J
authors.lastname: Kwan Kim
authors.forename: Seon-Hwa
authors.initials: SH
authors.lastname: Kang
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Noh
authors.forename: Jun-Yong
authors.initials: JY
authors.lastname: Ha
authors.forename: Jin
authors.initials: J
authors.lastname: Kyu Choi
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Lim
authors.forename: Shin
authors.initials: S
authors.lastname: Chung
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016861:Cyclooxygenase Inhibitors; D011714:Pyrans