Development of a recyclable fluorous chiral phase-transfer catalyst: application to the catalytic asymmetric synthesis of alpha-amino acids.
[structure: see text] A recyclable fluorous chiral phase-transfer catalyst was synthesized and successfully applied for the catalytic asymmetric synthesis of both natural and unnatural alpha-amino acids. The reaction involves alkylation of a glycine derivative followed by extractive recovery of the chiral phase-transfer catalyst using fluorous solvent.
Shirakawa
Seiji
S
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Tanaka
Youhei
Y
Maruoka
Keiji
K
D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000596:Amino Acids; D006845:Hydrocarbons, Fluorinated