[Heat shock proteins 70 kD as a new marker of lesions to target organs in hypertension].
The presence and concentration of the inducible form of heat shock proteins (Hsp70) were determined in blood serum of patients with hypertension (HT), stage II, including 28 males with stage II HT, who did not receive any antihypertensive therapy, and 10 healthy subjects. A higher Hsp70 content was found in blood serum of in patients with stage II HT. Such Hsp70 concentration was related with ECG signs of left ventricular hypertrophy and with the rennin content in blood. The findings of endothelium-dependent vasodilation (EDVD) of the radial artery did not differ within the examined groups. Still EDVD was reliable lower in patients with atherosclerotic plagues in the common carotid arteries. A reduced EDVD in the radial artery was attributed to a higher EDVD content in blood serum, which did not depend on a prescription or on an arterial hypertension severity. The results are indicative of that a higher inducible Hsp70 concentration in blood serum could potentially be a marker of lesions to target organs in HT; equally it could be of a certain significance in the atherosclerotic pathogenesis.
Moiseeva
O M
OM
Novoselov
S S
SS
Liasnikova
E A
EA
Ivanov
S Iu
SIu
Ivanova
T G
TG
Shliakhto
E V
EV
D015415:Biomarkers / Q000097:blood; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity
D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins