title: 1-(Alkyl/arylthiocarbamoyl)benzotriazoles as stable isothiocyanate equivalents: synthesis of Di- and trisubstituted thioureas.
abstract: 1-(Alkyl/arylthiocarbamoyl)benzotriazoles 4a-i were synthesized in yields of 91-99% from bis(benzotriazolyl)methanethione (3). Reagents 4a-g were then used as isothiocyanate equivalents for the efficient synthesis of 10 secondary and 14 tertiary thioureas in high-yielding, convenient processes.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Stephane
authors.initials: S
authors.lastname: Ledoux
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Witek
authors.forename: Satheesh K
authors.initials: SK
authors.lastname: Nair
mesh_terms: D017879:Isothiocyanates / Q000737:chemistry*; D015394:Molecular Structure; D013777:Tetrazoles / Q000138:chemical synthesis; D013859:Thiocarbamates / Q000737:chemistry*; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D014230:Triazoles / Q000737:chemistry*
chemical_list: D017879:Isothiocyanates; D013777:Tetrazoles; D013859:Thiocarbamates; D014230:Triazoles; C012771:benzotriazole; D013890:Thiourea