title: Isolation of salicin derivatives from Homalium cochinchinensis and their antiviral activities.
abstract: The chemical constituents of Homalium cochinchinensis were examined. From the root bark, in addition to the previously reported cochinolide and its beta-glucopyranoside, cochinchiside A (1) and tremulacinol (4) were isolated together with three known compounds [benzoic acid, tremulacin (2), and tremuloidin (3)]. From the leaves, cochinchiside B (5) was isolated as new compound. The structures of the new compounds (1, 4, 5) were determined by spectroscopic and/or chemical methods. Antiviral testing of compounds 2-5 against HSV-1 and HSV-2 showed that tremulacin (2) and cochinchiside B (5) were weakly active. Tremulacin (2) was also weakly active against HIV-1.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan. benti@p.chiba-u.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Kaori
authors.initials: K
authors.lastname: Nishigaya
authors.forename: Kazuko
authors.initials: K
authors.lastname: Takami
authors.forename: Hide
authors.initials: H
authors.lastname: Uchikoshi
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
authors.forename: Ian-Lih
authors.initials: IL
authors.lastname: Tsai
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001592:Benzyl Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008519:Medicine, Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031308:Salicaceae / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D001592:Benzyl Alcohols; D005960:Glucosides; C485317:cochinchiside A; C485318:cochinchiside B; C095421:tremulacin; C005696:salicin