title: Synthesis and cytotoxic activity of novel quinazolino-beta-carboline-5-one derivatives.
abstract: A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 microM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts.
authors.affiliation: Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500050, India.
authors.forename: Bipul
authors.initials: B
authors.lastname: Baruah
authors.forename: Kavitha
authors.initials: K
authors.lastname: Dasu
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Vaitilingam
authors.forename: Premkumar
authors.initials: P
authors.lastname: Mamnoor
authors.forename: Prasanthi Penubaka
authors.initials: PP
authors.lastname: Venkata
authors.forename: Sriram
authors.initials: S
authors.lastname: Rajagopal
authors.forename: Koteswar Rao
authors.initials: KR
authors.lastname: Yeleswarapu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011799:Quinazolines / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002243:Carbolines; D011799:Quinazolines