Possible absorption of antidiuretic hormone in isolated rat intestine.
Arginine-vasopressin or arginine-vasotocin hormones introduced into the small intestine are absorbed and exert a hydrosmotic effect. The amount of absorbed antidiuretic hormone increased when it is introduced with intestinal peptidase inhibitor aprotinin. These data attest to the possibility of absorption of pituitary hormones (vasotocin and vasopressin) in rat small intestine without losing their physiological activity.
Natochin
Yu V
YV
Department of Renal Physiology, I. M. Sechenov Institute of Evolution Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. natochin@iephb.ru
Shakhmatova
E I
EI
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001127:Arginine Vasopressin / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000502:physiology; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D009995:Osmosis / Q000187:drug effects; D010539:Permeability / Q000187:drug effects; D011896:Rana temporaria; D051381:Rats; D017208:Rats, Wistar; D001743:Urinary Bladder / Q000187:drug effects; D014668:Vasotocin / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000502:physiology
D001127:Arginine Vasopressin; D007611:Aprotinin; D014668:Vasotocin