Synthesis of [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole.
Selenium-75 (t1/2 = 120.4d; 100% EC) was prepared in no-carrier-added form by 22MeV proton-bombardment of natural arsenic(III) oxide powder held in a copper-aluminum drawer target (highest yield, 35 microCi/microAh; maximum current, 6 microA), followed by oxidation to [75Se]selenium(IV) oxide. No-carrier-added [75Se]5-ethoxycarbonyl-4-methyl-1,2,3-selenadiazole was prepared in one step from ethylacetoacetate semicarbazone with [75Se]selenium(IV) oxide in glacial acetic acid at 50 degrees C. Column chromatography of the final solution afforded the desired labeled compound in 30% yield and greater than 98% radiochemical purity.
Jalilian
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Cyclotron Department, Nuclear Research Center for Agriculture & Medicine, P.O. Box 31585-4395, Karaj, Iran. amirreza.jalilian@yale.edu
Rowshanfarzad
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P
Afarideh
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H
Shafiee
A
A
Sabet
M
M
Kyoumarsi
M
M
Raisali
Gh R
GR
D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000737:chemistry; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D016566:Organoselenium Compounds / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D011522:Protons; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012644:Selenium Radioisotopes / Q000737:chemistry*; D013696:Temperature
D001152:Arsenicals; D001393:Azoles; D016566:Organoselenium Compounds; D010087:Oxides; D011522:Protons; D019275:Radiopharmaceuticals; D012644:Selenium Radioisotopes; D000077237:Arsenic Trioxide