Prior antimicrobial agent use increases the risk of sporadic infections with multidrug-resistant Salmonella enterica serotype Typhimurium: a FoodNet case-control study, 1996-1997.
Several strains of multidrug-resistant (MDR) Salmonella serotype Typhimurium, including MDR S. Typhimurium definitive type 104, cause almost 10% of Salmonella infections among humans in the United States. To determine the risk factors for acquiring sporadic MDR S. Typhimurium infection, we conducted a population-based, case-control study using data from the Foodborne Diseases Active Surveillance Network (FoodNet) during 1996-1997. S. Typhimurium isolates from 5 FoodNet surveillance areas (California, Connecticut, Georgia, Minnesota, and Oregon) were tested for antimicrobial resistance and phage typing. Telephone interviews were conducted with ill persons and matched control subjects. Compared with both control subjects and patients infected with pansensitive strains of S. Typhimurium, patients with MDR S. Typhimurium infection were significantly more likely to have received an antimicrobial agent, particularly an agent to which the Salmonella isolate was resistant, during the 4 weeks preceding illness onset. Prudent antimicrobial agent use among humans and among veterinarians and food-animal producers is necessary to reduce the burden of drug-resistant salmonellosis in humans.
Glynn
M Kathleen
MK
Division of Bacterial and Mycotic Disease, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. kglynn@cdc.gov
Reddy
Vasudha
V
Hutwagner
Lori
L
Rabatsky-Ehr
Therese
T
Shiferaw
Beletshachew
B
Vugia
Duc J
DJ
Segler
Suzanne
S
Bender
Jeff
J
Barrett
Timothy J
TJ
Angulo
Frederick J
FJ
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D007255:Information Services; D008297:Male; D012307:Risk Factors; D012478:Salmonella Food Poisoning / Q000453:epidemiology / Q000503:physiopathology*; D012480:Salmonella Infections / Q000453:epidemiology / Q000503:physiopathology*; D012486:Salmonella typhimurium / Q000187:drug effects*; D012703:Serotyping
D000900:Anti-Bacterial Agents