Rosai-Dorfman disease manifesting as multiple subcutaneous nodules. Report of a case with diagnosis on a fine needle aspirate.
BACKGROUND
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a benign, self-limiting histiocytic proliferative disorder commonly involving the lymph nodes. Extranodal disease occurs in about 40% of cases, and the sites involved are skin, nasal cavity, paranasal sinuses, eyelids, orbit, bone and central nervous system.


METHODS
A case of RDD presented as subcutaneous nodules and was diagnosed on a fine needle aspirate. The aspirate revealed numerous histiocytes with phagocytosis of lymphocytes, plasma cells and neutrophils. Surgical biopsy and immunocytochemical stain for S-100 protein confirmed the diagnosis. Later the patient developed lymphadenopathy and involvement of the nasal septum.


CONCLUSIONS
Extranodal RDD can be diagnosed by FNAC in conjunction with immunocytochemistry.
Singh
N Gopendro
NG
Cytopathology Laboratory, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
Kapila
Kusum
K
Mathur
Sandeep
S
Ray
Ruma
R
Verma
Kusum
K
D000328:Adult; D014408:Biomarkers, Tumor; D044963:Biopsy, Fine-Needle; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D007962:Leukocytes / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology; D009300:Nasal Septum / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D040521:Subcutaneous Tissue / Q000473:pathology*
D014408:Biomarkers, Tumor; D009418:S100 Proteins