title: [A case of probable bacterial translocation-associated sepsis in healthy adult].
abstract: We report a patient with bacterial translocation-associated sepsis who was healthy and did not have any related-background. The 57-year-old male had been well until 16 hours before admission, when nausea and vomiting gradually developed and increased in intensity. In the morning of May 22, 2002, he had shaking chills, temperature of 38.6 degrees C and watery diarrhea, and was admitted to Kawasaki Municipal Hospital. On admission, temperature was 40.7 degrees C but otherwise physical examination revealed no particular abnormality. Laboratory data showed total white blood cells of 28,400/microliter, platelet count of 130,000/microliter, creatinine of 2.0 mg/dl and C-reactive protein of 7.5 mg/dl. 1 g of cefmetazole was administered every eight hours. In the early morning of May 23, he suddenly went into shock. At that time, laboratory findings revealed total white blood cells of 33,700/microliter, platelet count of 65,000/microliter, C-reactive protein of 24.9 mg/dl, creatinine of 5.6 mg/dl and serum potassium concentration of 5.7 mEq/l. Gram positive cocci and gram negative rods were isolated from blood culture obtained on admission. Cefmetazole was changed to 1.5 g/day of imipenem/cilastatin sodium and 600 mg/day of clindamycin. In addition, hemodialysis and endotoxin removal with an adsorbent column using polymyxin B were performed. Bacteria detected in the blood on admission were identified as Klebsiela oxytoca and Enterococcus faecium. Imipenem/cilastatin sodium and clindamycin were continued for 13 days. The patient recovered fully and was discharged on June 11. This case suggests that bacterial translocation-associated sepsis might occur even in a hitherto healthy adult.
authors.affiliation: Department of Rheumatology, Kawasaki Municipal Hospital.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohosone
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Obana
authors.forename: Norihiko
authors.initials: N
authors.lastname: Koido
authors.forename: Satoshi
authors.initials: S
authors.lastname: Akizuki
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D018988:Bacterial Translocation; D016984:Enterococcus faecium / Q000302:isolation & purification; D006801:Humans; D041121:Klebsiella oxytoca / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000382:microbiology*