title: Seronegative infection and AIDS caused by an A2 subsubtype HIV-1.
abstract: The study of true seronegative HIV-1 infections may have important implications for the diagnosis and prevention of HIV-1 infection. The case of an AIDS patient with persistently negative HIV serology is described. Genetic and phylogenetic analysis indicated that she was infected with A2 subsubtype HIV-1 transmitted by her seropositive and asymptomatic sexual partner. The clinical and serological discordant results suggest the presence of an immunological deficiency that prevents the formation of HIV-1-specific antibodies.
authors.affiliation: Hospital Nossa Senhora da Graça, Tomar, Portugal.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Cardoso
authors.forename: Cristina
authors.initials: C
authors.lastname: Gonçalves
authors.forename: Dulce
authors.initials: D
authors.lastname: Pascoalinho
authors.forename: Carla
authors.initials: C
authors.lastname: Gil
authors.forename: António F
authors.initials: AF
authors.lastname: Ferreira
authors.forename: Inês
authors.initials: I
authors.lastname: Bártolo
authors.forename: Nuno
authors.initials: N
authors.lastname: Taveira
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D000328:Adult; D005260:Female; D018023:HIV Seronegativity; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology; D006801:Humans; D010802:Phylogeny