title: New beta-caryophyllene-derived terpenoids from the soft coral Sinularia nanolobata.
abstract: Two new norsesquiterpenoids, nanonorcaryophyllenes A (1) and B (2), two new diterpenoids, nanolobatins A (3) and B (4), and a novel norditerpenoid, nanolobatin C (5), were isolated from the n-hexane extract of the Taiwanese soft coral Sinularia nanolobata. Also, two new furanone derivatives, 6 and 7, were isolated for the first time from natural sources. The structures of 1-5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of the related metabolites. Nanonorcaryophyllenes A (1) and B (2) were characterized as 13-norcaryophyllenes that lack a methyl group at C-11, while nanolobatin C (5) represents the first example of a xeniaphyllane-based 17-norditerpenoid. The cytotoxicity of 1-6 against the growth of a limited panel of cancer cell lines is also described.
authors.affiliation: Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Atallah F
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Ru-Ting
authors.initials: RT
authors.lastname: Shiue
authors.forename: Xin-Jie
authors.initials: XJ
authors.lastname: Pan
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D009792:Oceans and Seas; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D012717:Sesquiterpenes; C485068:nanolobatin A; C485069:nanolobatin B; C485066:nanonorcaryophyllene A; C485067:nanonorcaryophyllene B