title: How T cells use LFA-1 to attach and migrate.
abstract: The T lymphocyte (or T cell) has classically been perceived to be a passive circular cell attaching to other cells or fibrils of the extracellular matrix when its integrins become activated. We now understand that the modus operandi of the T cell is migration. These cells are proving to be impressively fast migrators, clocking up basal speeds of approximately 10-15 microm/min which makes them amongst the fastest movers recorded to date. Therefore, migration is the business of the T cell and in this review we will discuss how its motility is regulated and what functions this activity makes possible.
authors.affiliation: Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK. nancy.hogg@cancer.org.uk
authors.forename: Nancy
authors.initials: N
authors.lastname: Hogg
authors.forename: Andrew
authors.initials: A
authors.lastname: Smith
authors.forename: Alison
authors.initials: A
authors.lastname: McDowall
authors.forename: Katherine
authors.initials: K
authors.lastname: Giles
authors.forename: Paula
authors.initials: P
authors.lastname: Stanley
authors.forename: Melanie
authors.initials: M
authors.lastname: Laschinger
authors.forename: Robert
authors.initials: R
authors.lastname: Henderson
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000276:immunology / Q000502:physiology; D002465:Cell Movement / Q000276:immunology / Q000502:physiology*; D003599:Cytoskeleton / Q000276:immunology / Q000502:physiology; D006801:Humans; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D013915:Thrombasthenia / Q000276:immunology
chemical_list: D016169:Lymphocyte Function-Associated Antigen-1