Aspirin, NSAIDs, risk of dementia, and influence of the apolipoprotein E epsilon 4 allele in an elderly population.
In a cohort study, 1,301 subjects free of dementia at baseline in the Kungsholmen Project were followed up to 6 years. We studied the association between use of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), incidence of Alzheimer's disease (AD) and overall dementia, and the influence of the apolipoprotein E epsilon4 allele. In stratified analyses, a relative risk (RR) of 1.80 (95% CI 1.14-2.83) for AD was seen, in the apoE epsilon4-negative group using aspirin. This implicates a possible different mechanism of developing AD in this group. We also found a possible protective effect of NSAIDs against AD, since no one who used NSAIDs for around 3 years had developed AD 3 years later. One user developed vascular dementia, and a low point value of risk was seen, however, not significant (RR 0.23; 95% CI 0.03-1.68). This could be due to the small samples in our study, or to comorbidity contributing to the development of dementia in this elderly population.
Cornelius
C
C
Aging Research Centre, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm Gerontology Research Centre, Stockholm, Sweden. Christel.Cornelius@neurotec.ki.se
Fastbom
J
J
Winblad
B
B
Viitanen
M
M
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics* / Q000517:prevention & control*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001241:Aspirin / Q000008:administration & dosage*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D015140:Dementia, Vascular / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D016133:Polymerase Chain Reaction; D013548:Sweden
D000894:Anti-Inflammatory Agents, Non-Steroidal; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin