[Genetic risk factors of venous thromboembolism].
Up to date several hereditary disorders have been identified as prothrombic risk factors. The most common inherited thrombotic disorders include activated protein C resistance (factor V Leiden), prothrombin G20210A mutation, hyperhomocysteinemia, deficiencies of protein C, protein S, antithrombin III, and thrombomodulin. This article focuses on the clinical and the laboratory aspects of some of the inherited venous thrombotic disorders including the factor V Leiden, prothrombin G20210A mutation and protein S deficiency.
Oner
Ferda
F
Ankara University Faculty of Medicine, Pulmonary Diseases, Ankara, Turkey. onerferda@hotmail.com
Kaya
Akin
A
Doğan
Ruşina
R
Numanoğlu
Numan
N
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000235:genetics*; D005165:Factor V / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D018455:Protein S Deficiency / Q000235:genetics; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D020246:Venous Thrombosis / Q000175:diagnosis / Q000235:genetics*
D001779:Blood Coagulation Factors; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin