Synthesis of a three-member array of cycloadducts in a glass microchip under pressure driven flow.
The synthesis of a series of cycloadduct products carried out in a glass microchip under pressure driven flow is presented. Initially, four different compounds were synthesized individually with conversions similar to those obtained in the corresponding batch macroscale reactions. Using identical experimental conditions for all four compounds, the results were highly predictable and reproducible, without the need for individual optimization. A multi-reaction experiment was then carried out in a single chip achieving the synthesis of a three-member array in a single run.
Fernandez-Suarez
Miryam
M
GlaxoSmithKline Pharmaceuticals, New Frontiers Science Park (North), Harlow, UKCM19 5AW. miryam_1_fernandez-suarez@gsk.com
Wong
Stephanie Y
SY
Warrington
Brian H
BH