Disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin in rat and monkey red blood cells and liver.
The disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin were compared in rat and monkey red blood cells and liver. Our data reveal that the total ribavirin-related components (ribavirin plus its mono-, di-, and triphosphate metabolites) may account for most of the drug in monkey liver following prolonged oral administration of viramidine.
Lin
Chin-Chung
CC
Research and Development, Valeant Pharmaceuticals International, Costa Mesa, California 92626, USA. cclin@valeant.com
Lourenco
David
D
Xu
Guifen
G
Yeh
Li-Tain
LT
D000818:Animals; D000998:Antiviral Agents / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001711:Biotransformation; D002848:Chromatography, DEAE-Cellulose; D004912:Erythrocytes / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008252:Macaca fascicularis; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*
D000998:Antiviral Agents; D012254:Ribavirin; C026956:taribavirin