title: Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease.
abstract: BACKGROUND
  Alloimmune incompatibility in allo-geneic stem cell transplantation (ASCT), pregnancy, and blood transfusion might trigger an immune response with clinical consequences. Human PLT antigens (HPAs), which play a significant role in pregnancy or blood transfusion-associated alloimmune thrombocytopenia, are also expressed on the surface of tissues affected by GVHD. Thus, HPA mismatch in HLA-identical ASCT could play a potential role in PLT engraftment and GVHD.
  
  
  METHODS
  We studied the HPA-1, -2, and -5 genotypes in Caucasian donors and patients involved in 77 HLA-identical ASCTs. We evaluated the association of HPA compatibility with clinical outcome, analyzing the relevance of host-versus-donor HPA incompatibility in PLT engraftment and donor-versus-host HPA incompatibility in GVHD.
  
  
  RESULTS
  PLT engraftment and transfusion require-ments were similar in HPA-compatible and HPA-incompatible ASCT. Cases with severe thrombocytopenia or significant delayed PLT engraftment did not display host-versus-donor HPA incompatibility. Moreover, the incidence of GVHD did not correlate with HPA compatibility.
  
  
  CONCLUSIONS
  Our results support no role for these antigens in immune complications of ASCT: PLT engraftment, requirement of PLT transfusions, and GVHD.
authors.affiliation: University of Murcia, Department of Medicine, Murcia, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: García-Malo
authors.forename: J
authors.initials: J
authors.lastname: Corral
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: C
authors.initials: C
authors.lastname: Solano
authors.forename: R
authors.initials: R
authors.lastname: González-Conejero
authors.forename: M D
authors.initials: MD
authors.lastname: Caballero
authors.forename: R
authors.initials: R
authors.lastname: Pérez
authors.forename: J M
authors.initials: JM
authors.lastname: Moraleda
authors.forename: V
authors.initials: V
authors.lastname: Vicente
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016824:Antigens, Human Platelet / Q000032:analysis / Q000276:immunology*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D017713:Platelet Transfusion; D014184:Transplantation, Homologous
chemical_list: D016824:Antigens, Human Platelet