title: In vitro-in vivo antifungal evaluation and structure-activity relationships of 3H-1,2-dithiole-3-thione derivatives.
abstract: As part of our project devoted to the search of new antifungal agents, we report here the in vitro-in vivo antifungal evaluations and a structure-activity relationship (SAR) study of 17 thione derivatives. Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the biological response.
authors.affiliation: Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis (UNSL), Chacabuco y Pedernera, San Luis 5700, Argentina.
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Giannini
authors.forename: Mario L
authors.initials: ML
authors.lastname: Aimar
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Sortino
authors.forename: Roxana
authors.initials: R
authors.lastname: Gomez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Sturniollo
authors.forename: Americo
authors.initials: A
authors.lastname: Juarez
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
authors.forename: Rita H
authors.initials: RH
authors.lastname: de Rossi
authors.forename: Ricardo D
authors.initials: RD
authors.lastname: Enriz
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013329:Structure-Activity Relationship; D013871:Thiones / Q000737:chemistry* / Q000627:therapeutic use; D013876:Thiophenes / Q000737:chemistry* / Q000627:therapeutic use; D014005:Tinea / Q000188:drug therapy; D014316:Tritium / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D013871:Thiones; D013876:Thiophenes; D014316:Tritium; C049325:1,2-dithiol-3-thione