title: [Anti-arrhythmia activity of derinat in an experiment].
abstract: The acute toxicity of the immunostimulant derinat is very low: the LD50 value for intraperitoneal administration exceeds 1000 mg/kg. The drug effectively prevents from acute arrhythmia development upon occlusion in cats and produces antifibrillator effect on a model of reperfusive arrhythmia in a dose of 7.5 mg/kg. Derinat also exhibits the antiarrhythmic activity on the model of adrenalin-induced rhythm violations, but appears ineffective on the calcium chloride model.
authors.affiliation: Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Sviatkina
authors.forename: V P
authors.initials: VP
authors.lastname: Balashov
authors.forename: L A
authors.initials: LA
authors.lastname: Balykova
authors.forename: S A
authors.initials: SA
authors.lastname: Shchukin
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D004247:DNA / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051381:Rats
chemical_list: D000276:Adjuvants, Immunologic; D000889:Anti-Arrhythmia Agents; D004247:DNA