title: Effect of a high-protein, high-salt diet on calcium and bone metabolism in postmenopausal women stratified by hormone replacement therapy use.
abstract: The objective of this study was to investigate the influence of a high-sodium, high-protein diet on bone metabolism in postmenopausal women (aged 49-60 y) stratified by hormone replacement therapy (HRT) use. In a crossover trial, 18 women (n = 8 HRT users (+HRT) and n = 10 nonusers (-HRT)) were randomly assigned to a diet high in protein (90 g/day) and sodium (180 mmol/day) (calciuric diet) or a diet moderate in protein (70 g/day) and low in sodium (65 mmol/day) for 4 weeks followed by crossover to alternative dietary regimen for a further 4 weeks. The calciuric diet significantly (P < 0.05) increased urinary sodium, calcium and nitrogen in both groups. While the calciuric diet increased urinary N-telopeptide crosslinks of collagen (by approximately 25%, P = 0.003) in the -HRT group, it had no effect in the +HRT group. It appears that postmenopausal HRT use attenuates the increase in a marker of bone resorption associated with a calciuric diet.
authors.affiliation: Department of Food and Nutritional Sciences, University College, Cork, Ireland.
authors.forename: M
authors.initials: M
authors.lastname: Harrington
authors.forename: T
authors.initials: T
authors.lastname: Bennett
authors.forename: J
authors.initials: J
authors.lastname: Jakobsen
authors.forename: L
authors.initials: L
authors.lastname: Ovesen
authors.forename: C
authors.initials: C
authors.lastname: Brot
authors.forename: A
authors.initials: A
authors.lastname: Flynn
authors.forename: K D
authors.initials: KD
authors.lastname: Cashman
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000378:metabolism; D002762:Cholecalciferol / Q000097:blood; D018592:Cross-Over Studies; D004044:Dietary Proteins / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D009584:Nitrogen / Q000652:urine; D010281:Parathyroid Hormone / Q000097:blood; D017698:Postmenopause; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000097:blood / Q000652:urine
chemical_list: D002136:Calcium, Dietary; D004044:Dietary Proteins; D010281:Parathyroid Hormone; D012982:Sodium, Dietary; D002762:Cholecalciferol; D009584:Nitrogen; D002118:Calcium