Immunomodulation of chickens with the nonionic block polymer T150R1.
Chickens injected subcutaneously at one day of age with oil-in-water emulsions of the nonioinic block polymer T150R1 developed higher titres to sheep erythrocytes and killed Brucella abortus than did untreated chickens when they were immunised with the antigens one and two weeks later. The increase was IgM only. Cell-mediated immunity was not affected as measured by blastogenic responses. Morphometric analysis of tissue sections of bursae of Fabricius suggested the polymers were stimulating more rapid migration of B cells to peripheral organs.
Ragland
William L
WL
Department of Avian Medicine, University of Georgia, Athens, Georgia, USA. wrag@rudjer.irb.hr
Hunter
Robert L
RL
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000372:Agglutination Tests; D000818:Animals; D000831:Animals, Newborn; D002003:Brucella abortus / Q000276:immunology; D002060:Bursa of Fabricius / Q000033:anatomy & histology / Q000187:drug effects* / Q000276:immunology; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D005029:Ethylenediamines / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D019044:Image Cytometry; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008297:Male; D008623:Mercaptoethanol / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology*; D012737:Sex Factors; D013997:Time Factors; D014611:Vaccination
D000276:Adjuvants, Immunologic; D005029:Ethylenediamines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C012571:tetronic 701; D011092:Polyethylene Glycols; D008623:Mercaptoethanol