Subthalamic stimulation differentially modulates declarative and nondeclarative memory.
Declarative memory has been reported to rely on the medial temporal lobe system, whereas non-declarative memory depends on basal ganglia structures. We investigated the functional role of the subthalamic nucleus (STN), a structure closely connected with the basal ganglia for both types of memory. Via deep brain high frequency stimulation (DBS) we manipulated neural activity of the STN in humans. We found that DBS-STN differentially modulated memory performance: declarative memory was impaired, whereas non-declarative memory was improved in the presence of STN-DBS indicating a specific role of the STN in the activation of memory systems.
Hälbig
Thomas D
TD
Department of Neurology, Charité-University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, D-13353 Berlin, Germany. thomas.haelbig@mssm.edu
Gruber
Doreen
D
Kopp
Ute A
UA
Scherer
Peter
P
Schneider
Gerd-Helge
GH
Trottenberg
Thomas
T
Arnold
Guy
G
Kupsch
Andreas
A
D000368:Aged; D001479:Basal Ganglia / Q000502:physiology; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008839:Microelectrodes; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000502:physiology*