title: Hevin/SC1, a matricellular glycoprotein and potential tumor-suppressor of the SPARC/BM-40/Osteonectin family.
abstract: Hevin is an extracellular matrix-associated, secreted glycoprotein belonging to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins. It contains three conserved structural domains that are implicated in the regulation of cell adhesion, migration, and proliferation. Hevin is expressed during embryogenesis and tissue remodeling and is especially prominent in brain and vasculature. Its down-regulation in a number of cancers and the possibility of its functional compensation by SPARC has led to recent interest in hevin as a tumor suppressor and regulator of angiogenesis.
authors.affiliation: Department of Vascular Biology, The Hope Heart Institute, 1124 Columbia Street, Seattle, WA 98104, USA. msullivan@hopehart.org
authors.forename: Millicent M
authors.initials: MM
authors.lastname: Sullivan
authors.forename: E Helene
authors.initials: EH
authors.lastname: Sage
mesh_terms: D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D002448:Cell Adhesion; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use; D006031:Glycosylation; D006801:Humans; D015676:Osteonectin / Q000235:genetics; D017434:Protein Structure, Tertiary / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D015676:Osteonectin; C503126:SPARCL1 protein, human; D025521:Tumor Suppressor Proteins