title: Validation of a capillary zone electrophoresis method for determination of rimantadine hydrochloride in Rimantadin100 tablets and the method application to dissolution test monitoring.
abstract: A capillary zone electrophoretic method with indirect UV-detection for determination of rimantadine, an antiviral drug against influenza A, in tablets was validated. Instrumental precision, the method precision, accuracy, calibration curve linearity, selectivity, robustness, and time stability of the sample and the standard were tested. The method was also applied to monitor dissolution tests of the tablets. The possibility of addition of an internal standard for improvement of the method precision was discussed.
authors.affiliation: Department of Analytical Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic. pazourek@chemi.muni.cz
authors.forename: J
authors.initials: J
authors.lastname: Pazourek
authors.forename: A L
authors.initials: AL
authors.lastname: Revilla
authors.forename: D
authors.initials: D
authors.lastname: Gajdosová
authors.forename: J
authors.initials: J
authors.lastname: Havel
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods*; D019384:Nucleic Acid Synthesis Inhibitors / Q000032:analysis* / Q000737:chemistry; D012299:Rimantadine / Q000032:analysis* / Q000737:chemistry; D012995:Solubility; D013607:Tablets
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D013607:Tablets; D012299:Rimantadine