Noninvasive optical imaging in the visual cortex in young infants.
During the developmental stage, the brain undergoes anatomic, functional, and metabolic changes necessary to support the complex adaptive behavior of a mature individual. Estimation of developmental changes occurring in different regions of the brain would provide a means of relating various behavioral phenomena to maturation-specific brain structures, thereby providing useful information on structure-function relationships in both normal and disease states. We used multichannel near-infrared spectroscopy (MNIRS), a new noninvasive imaging technique for revealing the course of neural activity in selected brain regions, to monitor the activities of the visual cortex as mirrored by hemodynamic responses in infants subjected to photostimulation during natural sleep. In the infants, oxyhemoglobin and total hemoglobin decreased and deoxyhemoglobin increased in the visual cortex with photostimulation. This pattern of responses was different from the response pattern in adults reported previously. The different patterns of responses to photostimulation in the visual cortices of infants and adults might reflect developmental and behavioral differences. It may reflect a different functional organization of the visual cortex in infants or ongoing retinal development. Our results demonstrated that regional hemodynamic change could be detected in a small area around the visual cortex. MNIRS offers considerable potential for research and noninvasive clinical applications.
Kusaka
Takashi
T
Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kagawa, Japan. kusaka@kms.ac.jp
Kawada
Kou
K
Okubo
Kensuke
K
Nagano
Keiko
K
Namba
Masanori
M
Okada
Hitoshi
H
Imai
Tadashi
T
Isobe
Kenichi
K
Itoh
Susumu
S
D000328:Adult; D001931:Brain Mapping; D006454:Hemoglobins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010108:Oxyhemoglobins / Q000032:analysis / Q000378:metabolism; D010775:Photic Stimulation; D012890:Sleep / Q000502:physiology*; D019265:Spectroscopy, Near-Infrared; D014793:Visual Cortex / Q000502:physiology*
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin