The thrombospondin type 1 repeat superfamily.
The TSR superfamily is a diverse family of extracellular matrix and transmembrane proteins, many of which have functions related to regulating matrix organization, cell-cell interactions and cell guidance. This review samples some of the contemporary literature regarding TSR superfamily members (e.g. F-spondin, UNC-5, ADAMTS, papilin, and TRAP) where specific functions are assigned to the TSR domains. Combining these observations with the published crystal structure of the TSRs of thrombospondin-1 may hold a key to the development of therapeutic agents for fighting parasitic infection and tumor growth.
Tucker
Richard P
RP
Department of Cell Biology and Human Anatomy, School of Medicine, University of California at Davis, 1 Shields Avenue, Davis, CA 95616, USA. rptucker@ucdavis.edu
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008288:Malaria / Q000378:metabolism; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy; D017434:Protein Structure, Tertiary / Q000235:genetics; D019700:Thrombospondin 1 / Q000737:chemistry* / Q000502:physiology* / Q000627:therapeutic use
D019700:Thrombospondin 1