[A psychoneurophysiological evaluation of non-specific cerebral systems in patients with permanent autonomic disorders of psychogenic etiology during therapy].
Fifteen patients with permanent vegetative disorders combined with a pronounced anxiety were examined before and after treatment by the Nott drug. The clinical-and-neurological technique, psychometric evaluation of cognitive functions and the neurophysiological method of acoustic cognitive induced potentials P300 were made use of. Before treatment, pronounced vegetative anxiety-related and cognitive disorders were observed in patients. A reliably decreased amplitude of the P300 peak was noted in patients versus healthy subjects while registering the cognitive induced potentials. After treatment, there was a reliably decreased severity of vegetative, anxious and cognitive disorders in patients; the P300 amplitude went up reliably. Supposedly, the changed P300 amplitude, as observed in patients with permanent vegetative disorders; denotes the malfunction in non-specific limbic-reticular brain structures. A growing P300-peak amplitude combined with the arrest of psychovegetative and anxious disorders and with an improvement of cognitive functions in patients due to therapy are indicative of a lower degree of the functional disintegration in the non-specific limbic-reticular brain structures. Finally, the method of endogenous induced P300 potentials can be used as a diagnostic tool in the objective evaluation of a condition of non-specific brain systems in patients with the psychovegetative syndrome; it can also be an objective criterion in the efficiency assessment of a conducted therapy.
Gordeev
S A
SA
Fedotova
A V
AV
Posokhov
S I
SI
Solov'eva
A D
AD
Veĭn
A M
AM
D000328:Adult; D001007:Anxiety / Q000523:psychology; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D003071:Cognition; D018913:Event-Related Potentials, P300; D005260:Female; D006801:Humans; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D011594:Psychometrics; D011602:Psychophysiologic Disorders / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D012154:Reticular Formation / Q000503:physiopathology*