Echocardiographic assessment of global ventricular function using the myocardial performance index in rats with hypertrophy.
Myocardial hypertrophy is the hallmark of chronic pressure overload and the myocardial performance index (MPI) is an easily recordable measurement of Doppler time intervals. In this study, the utility of using MPI to assess the progression of hypertrophy in the aortic-banded rat model was evaluated. Male Wistar rats (70-90 g) underwent ascending aorta constriction (n = 4) or a sham operation (n = 5). High-resolution echocardiography was performed 4, 7, 10, and 12 weeks after the surgery. Over this follow-up interval, animals in the aortic-banded group demonstrated an increase in their mean left ventricular (LV) mass and MPI compared with controls. MPI reflects ventricular performance in small animals with LV hypertrophy, showing alterations early after aorta constriction.
Salemi
Vera M C
VM
Cardiomyopathy Unit, Heart Institute (InCor), University of São Paulo Medical School, Sao Paulo, Brazil. verasalemi@uol.com.br
Pires
Mara D
MD
Cestari
Ismar N
IN
Cestari
Idágene A
IA
Picard
Michael H
MH
Leirner
Adolfo A
AA
Mady
Charles
C
D000818:Animals; D001011:Aorta / Q000601:surgery; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D003250:Constriction; D004452:Echocardiography / Q000379:methods; D006339:Heart Rate / Q000502:physiology; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D023421:Models, Animal; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar