Acquired myasthenia gravis associated with a non-invasive thymic carcinoma in a dog.
An 8 1/2-year-old neutered male Beagle was diagnosed with acquired myasthenia gravis associated with a non-invasive thymic carcinoma. The thymic mass was surgically excised and the dog was treated with pyridostigmine, prednisolone and azathioprine. Serial acetylcholine receptor antibody titres were increased initially but slowly declined to normal values over a period of 24 weeks. Improved exercise tolerance was seen following therapy, however, oesophageal dysfunction persisted. The dog was euthanased 26 weeks after initial presentation due to a complicating illness. A necropsy showed no regrowth or metastasis of the thymic carcinoma.
Stenner
V J
VJ
Department of Veterinary Clinic and Hospital, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030. vstenner@powerup.com.au
Parry
B W
BW
Holloway
S A
SA
D000109:Acetylcholine / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000097:blood; D004283:Dog Diseases / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D004285:Dogs; D004931:Esophageal Achalasia / Q000209:etiology / Q000662:veterinary; D008297:Male; D009157:Myasthenia Gravis / Q000209:etiology / Q000662:veterinary*; D009364:Neoplasm Recurrence, Local; D011950:Receptors, Cholinergic / Q000276:immunology; D013945:Thymoma / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D013953:Thymus Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*
D000906:Antibodies; D011950:Receptors, Cholinergic; D000109:Acetylcholine