title: The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.
abstract: Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
authors.affiliation: The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. dvu@tigr.org
authors.forename: John F
authors.initials: JF
authors.lastname: Heidelberg
authors.forename: Rekha
authors.initials: R
authors.lastname: Seshadri
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Haveman
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Hemme
authors.forename: Ian T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: James F
authors.initials: JF
authors.lastname: Kolonay
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Eisen
authors.forename: Naomi
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authors.lastname: Ward
authors.forename: Barbara
authors.initials: B
authors.lastname: Methe
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Brinkac
authors.forename: Sean C
authors.initials: SC
authors.lastname: Daugherty
authors.forename: Robert T
authors.initials: RT
authors.lastname: Deboy
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Dodson
authors.forename: A Scott
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authors.lastname: Durkin
authors.forename: Ramana
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authors.lastname: Madupu
authors.forename: William C
authors.initials: WC
authors.lastname: Nelson
authors.forename: Steven A
authors.initials: SA
authors.lastname: Sullivan
authors.forename: Derrick
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authors.lastname: Fouts
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Haft
authors.forename: Jeremy
authors.initials: J
authors.lastname: Selengut
authors.forename: Jeremy D
authors.initials: JD
authors.lastname: Peterson
authors.forename: Tanja M
authors.initials: TM
authors.lastname: Davidsen
authors.forename: Nikhat
authors.initials: N
authors.lastname: Zafar
authors.forename: Liwei
authors.initials: L
authors.lastname: Zhou
authors.forename: Diana
authors.initials: D
authors.lastname: Radune
authors.forename: George
authors.initials: G
authors.lastname: Dimitrov
authors.forename: Mark
authors.initials: M
authors.lastname: Hance
authors.forename: Kevin
authors.initials: K
authors.lastname: Tran
authors.forename: Hoda
authors.initials: H
authors.lastname: Khouri
authors.forename: John
authors.initials: J
authors.lastname: Gill
authors.forename: Terry R
authors.initials: TR
authors.lastname: Utterback
authors.forename: Tamara V
authors.initials: TV
authors.lastname: Feldblyum
authors.forename: Judy D
authors.initials: JD
authors.lastname: Wall
authors.forename: Gerrit
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authors.lastname: Voordouw
authors.forename: Claire M
authors.initials: CM
authors.lastname: Fraser
mesh_terms: D016969:Desulfovibrio vulgaris / Q000235:genetics* / Q000378:metabolism; D004734:Energy Metabolism; D016680:Genome, Bacterial; D008969:Molecular Sequence Data