Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction.
Fasan
Rudi
R
Institute of Organic Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Dias
Ricardo L A
RL
Moehle
Kerstin
K
Zerbe
Oliver
O
Vrijbloed
Jan W
JW
Obrecht
Daniel
D
Robinson
John A
JA
D000595:Amino Acid Sequence; D001665:Binding Sites; D032701:Biomimetics; D015374:Biosensing Techniques; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000737:chemistry* / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism
D008024:Ligands; D009687:Nuclear Proteins; D010456:Peptides, Cyclic; D011518:Proto-Oncogene Proteins; D016159:Tumor Suppressor Protein p53; D051736:Proto-Oncogene Proteins c-mdm2