title: Synthesis, biological activity, and quantitative structure-activity relationship study of azanaphthalimide and arylnaphthalimide derivatives.
abstract: A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.
authors.affiliation: Departamento de Ciencias Químicas, Universidad San Pablo CEU, Urbanización Montepríncipe, 28668-Boadilla del Monte, Madrid, Spain. mfbrana@ceu.es
authors.forename: Miguel F
authors.initials: MF
authors.lastname: Braña
authors.forename: Ana
authors.initials: A
authors.lastname: Gradillas
authors.forename: Angel
authors.initials: A
authors.lastname: Gómez
authors.forename: Nuria
authors.initials: N
authors.lastname: Acero
authors.forename: Francisco
authors.initials: F
authors.lastname: Llinares
authors.forename: Dolores
authors.initials: D
authors.lastname: Muñoz-Mingarro
authors.forename: Cristina
authors.initials: C
authors.lastname: Abradelo
authors.forename: Fernanda
authors.initials: F
authors.lastname: Rey-Stolle
authors.forename: Mercedes
authors.initials: M
authors.lastname: Yuste
authors.forename: Joaquín
authors.initials: J
authors.lastname: Campos
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Gallo
authors.forename: Antonio
authors.initials: A
authors.lastname: Espinosa
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D021281:Quantitative Structure-Activity Relationship; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001372:Aza Compounds; D006575:Heterocyclic Compounds, 3-Ring; D007094:Imides; D009281:Naphthalenes; D011804:Quinolines