Reduction of mitochondrial DNA content and respiratory chain activity occurs in adipocytes within 6-12 months of commencing nucleoside reverse transcriptase inhibitor therapy.
Hammond
Emma
E
Nolan
David
D
James
Ian
I
Metcalf
Cecily
C
Mallal
Simon
S
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D004272:DNA, Mitochondrial / Q000032:analysis* / Q000187:drug effects; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D015497:HIV-1; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D004272:DNA, Mitochondrial; D018894:Reverse Transcriptase Inhibitors; D003576:Electron Transport Complex IV