title: The impact of APOE on myocardial infarction, stroke, and dementia: the Rotterdam Study.
abstract: It is unclear how the APOE genotype contributes to the incidence of vascular diseases and dementia. In a population-based sample (n = 6,852) with complete follow-up, APOE was weakly associated with myocardial infarction and not related with stroke. In the absence of epsilon4, the incidence of dementia would be 25.8% lower; in the absence of epsilon2/epsilon3, 2.8% higher. Risk estimates of dementia, specified for age, sex, and APOE, are provided for counseling. APOE is not strongly related to vascular diseases, but contributes substantially to dementia incidence.
authors.affiliation: Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: A J C
authors.initials: AJ
authors.lastname: Slooter
authors.forename: M
authors.initials: M
authors.lastname: Cruts
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: P J
authors.initials: PJ
authors.lastname: Koudstaal
authors.forename: D
authors.initials: D
authors.lastname: van der Kuip
authors.forename: M A J
authors.initials: MA
authors.lastname: de Ridder
authors.forename: J C M
authors.initials: JC
authors.lastname: Witteman
authors.forename: M M B
authors.initials: MM
authors.lastname: Breteler
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: C M
authors.initials: CM
authors.lastname: van Duijn
mesh_terms: D017677:Age Distribution; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D015331:Cohort Studies; D003704:Dementia / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D009426:Netherlands / Q000453:epidemiology; D016016:Proportional Hazards Models; D012306:Risk; D018570:Risk Assessment; D017678:Sex Distribution; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D001057:Apolipoproteins E