title: Variations in the genes encoding the peroxisome proliferator-activated receptors alpha and gamma in psoriasis.
abstract: The three peroxisome proliferator-activated receptor (PPAR) subtypes alpha, delta (beta), and gamma belong to the group of nuclear receptors that act as ligand-activated transcription factors. Recently, expression of PPAR alpha and gamma in keratinocytes has been demonstrated, and ligands of PPAR alpha and gamma have been found to enhance epidermal maturation and protect against cutaneous inflammation. There is evidence for a possible role of PPARs in psoriasis, as the expression of PPAR alpha and gamma is decreased in lesional skin and treatment with PPAR gamma agonists improves psoriatic keratinocyte pathology in vitro and in vivo. We performed a case-control study to search for possible associations between variations in the genes encoding PPAR alpha and gamma and psoriasis. Seven variations in these genes were analyzed in 192 patients with chronic plaque-type psoriasis and 330 healthy controls by PCR-based methods. No association between any of the investigated PPAR variants and psoriasis was found. Our findings argue against a significant contribution of the investigated PPAR variations to the genetic basis of psoriasis.
authors.affiliation: Department of Dermatology, Georg-August-University, Von-Siebold-Strasse 3, 37075 Goettingen, Germany.
authors.forename: Rotraut
authors.initials: R
authors.lastname: Mössner
authors.forename: Rolf
authors.initials: R
authors.lastname: Kaiser
authors.forename: Philipp
authors.initials: P
authors.lastname: Matern
authors.forename: Ullrich
authors.initials: U
authors.lastname: Krüger
authors.forename: Götz A
authors.initials: GA
authors.lastname: Westphal
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brockmöller
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Christine
authors.initials: C
authors.lastname: Neumann
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Kristian
authors.initials: K
authors.lastname: Reich
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D047493:PPAR alpha / Q000235:genetics*; D047495:PPAR gamma / Q000235:genetics*; D011565:Psoriasis / Q000235:genetics*
chemical_list: D047493:PPAR alpha; D047495:PPAR gamma