title: Renal safety of tenofovir in HIV treatment-experienced patients.
abstract: The safety of tenovir disoproxil fumarate (TDF) was assessed in two double-blind, placebo-controlled studies. Furthermore, we retrospectively collected 19 cases of TDF-associated tubular dysfunction. The incidence of renal events was similar among the active TDF groups and the placebo group in the two double-blind, placebo-controlled studies. Proximal tubulopathy was diagnosed 6.89 +/- 5.51 months after TDF therapy started. All abnormalities normalized within 4.7 +/- 2.94 weeks after drug discontinuation.
authors.affiliation: Department of Nephrology, Pitie-Salpêtrière Hospital, Paris, France.
authors.forename: Hassane
authors.initials: H
authors.lastname: Izzedine
authors.forename: Corinne
authors.initials: C
authors.lastname: Isnard-Bagnis
authors.forename: Jean Sébastien
authors.initials: JS
authors.lastname: Hulot
authors.forename: Daniel
authors.initials: D
authors.lastname: Vittecoq
authors.forename: Andrew
authors.initials: A
authors.lastname: Cheng
authors.forename: Carmen Kreft
authors.initials: CK
authors.lastname: Jais
authors.forename: Vincent
authors.initials: V
authors.lastname: Launay-Vacher
authors.forename: Gilbert
authors.initials: G
authors.lastname: Deray
mesh_terms: D000225:Adenine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D000225:Adenine