Discovery of novel nonsteroidal glucocorticoid receptor modulators.
A new class of selective nonsteroidal glucocorticoid receptor modulators typified by N-[3-[benzyl-(4-chloro-2-fluoro-benzyl)-amino]-2-methyl-phenyl]-methanesulfonamide 19 has been discovered.
Link
J T
JT
Metabolic Disease Research, Abbott Laboratories, Department 4CB, Bldg. AP-10, Rm. L-14, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. james.link@abbott.com
Sorensen
Bryan K
BK
Patel
Jyoti
J
Emery
Maurice
M
Grynfarb
Marlena
M
Goos-Nilsson
Annika
A
D000818:Animals; D001593:Benzyl Compounds; D006801:Humans; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides
D001593:Benzyl Compounds; C494076:N-(3-(benzyl-(4-chloro-2-fluoro-benzyl)-amino)-2-methyl-phenyl)-methanesulfonamide; D011965:Receptors, Glucocorticoid; D013449:Sulfonamides