[Chronic abdominal pain due to bowel ischemia in a patient with Leiden factor V mutation].
Leiden Factor V mutation, associated with resistance to activated protein C, is a prothrombotic state found in 20% of the patients with a first episode of deep-vein thrombosis. We report the case of a 30-Year-old woman with a history of intermittent abdominal pain who developed small bowel infarction requiring extensive small bowel resection. Biological search for prothrombotic disorder showed resistance to activated protein C due to homozygosity for the factor V Leiden mutation. Long-term anticoagulant therapy was initiated. Unexplained abdominal pain may be due to venous mesenteric ischemia, which can be associated with factor V Leiden mutation.
Chryssostalis
Ariane
A
Service de Médecine Interne et d'Hépatogastroentérologie, Centre Hospitalier Intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil.
Hagège
Hervé
H
Rosa-Hezode
Isabelle
I
Cattan
Philippe
P
De Lacroix-Szmania
Isabelle
I
Cabanis
Patrick
P
Bayani
Nazanin
N
Abd Alsamad
Issam
I
Chousterman
Michel
M
D015746:Abdominal Pain / Q000209:etiology*; D020016:Activated Protein C Resistance / Q000150:complications*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications / Q000209:etiology* / Q000473:pathology; D007511:Ischemia / Q000209:etiology*; D017354:Point Mutation
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V