[Peculiarities of duodenal ulcer with concomitant bronchial asthma (clinical and pathomorphological aspects)].
OBJECTIVE
To study incidence of gastroduodenal ulcer (GDU) in bronchial asthma and clinicomorphological features of ulcer disease in BA in long-term use of systemic corticosteroids (SCS) and without SCS.


METHODS
The trial covered 297 BA patients. They have undergone clinicoendoscopic examination of the gastroduodenal zone (GDZ) for duodenal ulcer with assessment of clinical gastroenterological symptoms and morphological analysis of biopsies of gastric and duodenal mucosa using histological, histochemical and morphometric methods.


RESULTS
BA patients were found to have high incidence of duodenal ulcer (21.9%). Morphologically, they had active immune inflammation with hyperergic component. The results of the study did not confirm the opinion about a key role of SCS in development of GDU in BA. Small doses of SCS in patients with BA and GDU do not deteriorate ulcerogenesis.


CONCLUSIONS
One of the factors determining combination of ulcer disease with BA may be chronic hyperergic inflammation of GDZ mucosa stimulating realization of predisposition to ulcer and its chronic recurrent course.
Cherniavskaia
G M
GM
Pleshko
R I
RI
Beloborodova
E I
EI
Sukhodolo
I V
IV
Plekhanova
E V
EV
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D004381:Duodenal Ulcer / Q000209:etiology / Q000473:pathology*; D004384:Duodenoscopy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000305:Adrenal Cortex Hormones