Antibacterial activity of glycine betaine analogues: involvement of osmoporters.
Glycine betaine (GB) analogues were obtained using solid phase organic synthesis and assayed for their toxic activity against 15 Gram positive and Gram negative bacteria. Four benzyl derivatives of GB were selected to determine their effect on bacterial growth. Bacteriostatic and lethal effects were observed for compound 1 and compound 2, respectively. The importation of the two GB analogues into bacterial cells appeared strictly dependent on the presence of the powerful betaine membrane osmoporters; their capacity to be amassed intracellularly at molar levels from extremely dilute solutions might constitute a basis to design a new class of antimicrobial agents.
Cosquer
Anne
A
Université de Rennes I, UMR CNRS 6026, Interactions Cellulaires et Moléculaires, Equipe Osmoadaptation chez les Bactéries, Campus de Beaulieu, 35042 Rennes, France.
Ficamos
Morgane
M
Jebbar
Mohamed
M
Corbel
Jean-Charles
JC
Choquet
Gwénaëlle
G
Fontenelle
Catherine
C
Uriac
Philippe
P
Bernard
Théophile
T
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001622:Betaine / Q000737:chemistry / Q000494:pharmacology*; D001692:Biological Transport; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D009995:Osmosis
D000900:Anti-Bacterial Agents; D001622:Betaine