title: Characteristics of tuberculosis patients with positive sputum smear in Catalonia, Spain.
abstract: BACKGROUND
  Patients with positive sputum smears are those with the capacity to spread infection. The objective of this study was to describe the incidence of tuberculosis in Catalonia (an autonomous community in the northeast of Spain which includes Barcelona) and to determine risk factors associated to patients with positive sputum smear test.
  
  
  METHODS
  New cases of tuberculosis detected by active surveillance between May 1996 and April 1997 were studied. The study was analysed as a coincident cases and controls study. The rate of incidence was calculated per 100,000 persons-year. The association of the dependent variable--case of tuberculosis with positive sputum smear--with the remainder of independent variables was determined by odds ratio (OR) with a 95% confidence interval (CI).
  
  
  RESULTS
  A total of 2508 cases of tuberculosis were detected. The rate of incidence was 41.4 per 100,000 persons-year. Of these 19.4% (487/2508) were coinfected with HIV and 35.6% (893/2508) presented a positive sputum smear, which implies a rate of 14.7 per 100,000 persons-year. In an adjusted multivariate analysis, cases with positive smears were positively associated with the 15-24 (OR=1.9; 95% CI: 1.4-2.4), 25-34 (OR=2.1; 95% CI: 1.7-2.7) and 35-44 years (OR=1.7; 95% CI: 1.3-2.2) age compared with persons 45 years old and above; with males (OR=1.8; 95% CI: 1.5-2.2) and consumers of alcohol (OR=2.1; 95% CI: 1.7-2.7) and negatively with those under 15 years of age (OR=0.1; 95% CI: 0.1-0.2) and coinfection with HIV (OR=0.5; 95% CI: 0.3-0.7).
  
  
  CONCLUSIONS
  Measures to control tuberculosis transmission (prompt diagnosis, study of contacts and directly observed treatments) should be reinforced for male adults with excessive consumption of alcohol.
authors.affiliation: Delegación Territorial de Sanidad y Seguridad Social, Lleida, Spain. pere.godoy@gencat.net
authors.forename: P
authors.initials: P
authors.lastname: Godoy
authors.forename: A
authors.initials: A
authors.lastname: Domínguez
authors.forename: J
authors.initials: J
authors.lastname: Alcaide
authors.forename: N
authors.initials: N
authors.lastname: Camps
authors.forename: J M
authors.initials: JM
authors.lastname: Jansà
authors.forename: S
authors.initials: S
authors.lastname: Minguell
authors.forename: J M
authors.initials: JM
authors.lastname: Pina
authors.forename: M
authors.initials: M
authors.lastname: Díez
mesh_terms: D006801:Humans; D015994:Incidence; D011159:Population Surveillance; D013030:Spain / Q000453:epidemiology; D013183:Sputum / Q000382:microbiology*; D014376:Tuberculosis / Q000453:epidemiology / Q000503:physiopathology* / Q000635:transmission