The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.
The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.
Manganelli
Riccardo
R
Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy.
Fattorini
Lanfranco
L
Tan
Dejiang
D
Iona
Elisabetta
E
Orefici
Graziella
G
Altavilla
Giuseppe
G
Cusatelli
Paola
P
Smith
Issar
I
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D005798:Genes, Bacterial; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D012808:Sigma Factor / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D014774:Virulence / Q000235:genetics / Q000502:physiology
D001426:Bacterial Proteins; D012808:Sigma Factor; D014157:Transcription Factors; C063202:sporulation-specific sigma factors