title: Human herpes virus 8-negative primary effusion lymphoma (PEL) in a patient after repeated chylous ascites and chylothorax.
abstract: We describe a case of malignant lymphoma which presented in the body cavities without identifiable tumor masses. Malignant lymphoma cells showed strong atypia with prominent nuclei and basophilic cytoplasm containing vacuoles. The chromosomes showed diploidy and complex abnormalities including translocations and deletions. We diagnosed this patient with primary effusion lymphoma (PEL), even though she tested negative for human herpes virus-8 (HHV-8) which has been suggested to be causally related to PEL. Interestingly, the patient also showed complicated protein-losing enteropathy, and PEL occurred after repeated chylous ascites and chylothorax. The possible pathogenesis of this rare disease is discussed here.
authors.affiliation: Department of Hematology, National Kyushu Medical Center, Fukuoka.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nonami
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Morishige
authors.initials: M
authors.lastname: Takeshita
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Akira
authors.initials: A
authors.lastname: Kubota
authors.forename: Seiichi
authors.initials: S
authors.lastname: Okamura
mesh_terms: D000328:Adult; D001399:Azure Stains; D002916:Chylothorax / Q000150:complications*; D002915:Chylous Ascites / Q000150:complications* / Q000473:pathology; D005260:Female; D006526:Hepatitis C / Q000150:complications; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000473:pathology / Q000821:virology; D016066:Pleural Effusion, Malignant / Q000150:complications / Q000000981:diagnostic imaging; D011504:Protein-Losing Enteropathies / Q000150:complications; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D001399:Azure Stains