title: Neuroimaging in mental retardation.
abstract: OBJECTIVE
  To determine the diagnostic yield of neuroimaging in a cohort of children with mental retardation of unknown origin.
  
  
  METHODS
  Neuroimaging was performed in a total of 47 patients with developmental delay/mental retardation, where no etiologic diagnosis could be made following clinical examination and preliminary investigations.
  
  
  RESULTS
  Thirty (63.82%) children had abnormal neuroimaging findings of which 19 (42.42%) were specific abnormalities useful in arriving at etiological diagnosis. Positive outcome of neuroimaging increased with the severity of mental retardation and in presence of microcephaly and neurologic deficits other than mental retardation.
  
  
  CONCLUSIONS
  Neuroimaging should be the standard clinical practice for a child with global developmental delay where no cause is apparent after examination and relevant investigations.
authors.affiliation: Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Pandey
authors.forename: Shubha R
authors.initials: SR
authors.lastname: Phadke
authors.forename: Neerja
authors.initials: N
authors.lastname: Gupta
authors.forename: R V
authors.initials: RV
authors.lastname: Phadke
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed