title: Nuclear transcription factor NF-kappa B: role in biology and medicine.
abstract: The inducible transcription factor nuclear factor-kappa B (NF-kappaB) plays a central role in regulation of many immune, inflammatory and carcinogenic responses. While normal activation of NF-kappaB is required for cell survival and immunity, aberrant regulation of NF-kappaB leads to development of many pathological states especially those involved in acute inflammation. Recent advances in our knowledge of the signaling mechanisms those control the activation of NF-kappaB highlights the intriguing aspect of NF-kappaB regulation, namely the ability of many different signal transduction pathways originating from a wide variety of inducing mechanisms to converge on a single target, the NF-kappaB/IkappaB complex. In this review we summarize our current understanding of the NF-kappaB signaling pathways, their role in various cellular responses and the potential of using NF-kappaB as a therapeutic target in modern medicine.
authors.affiliation: Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. Aggarwal@mdanderson.org
authors.forename: Bharat B
authors.initials: BB
authors.lastname: Aggarwal
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Takada
authors.forename: Shishir
authors.initials: S
authors.lastname: Shishodia
authors.forename: Angelica M
authors.initials: AM
authors.lastname: Gutierrez
authors.forename: Oommen V
authors.initials: OV
authors.lastname: Oommen
authors.forename: Haruyo
authors.initials: H
authors.lastname: Ichikawa
authors.forename: Yuh
authors.initials: Y
authors.lastname: Baba
authors.forename: Ashok
authors.initials: A
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001695:Biology; D004194:Disease; D006801:Humans; D016328:NF-kappa B / Q000502:physiology*
chemical_list: D016328:NF-kappa B