title: Increased rate of visual field loss associated with larger initial visual field threshold values on follow-up of open-angle glaucoma.
abstract: OBJECTIVE
  To determine the changes in the visual field over time and the factors that contribute to these changes on follow-up of open-angle glaucoma patients.
  
  
  METHODS
  From a retrospective review of patients' charts and visual fields, 30 eyes from 30 patients with open-angle glaucoma with a minimum of 3 years of follow-up were chosen. Visual fields were obtained with the Octopus perimeter about every 4 months. Regression analysis was used to obtain the slope for all the threshold values for each eye for the total field and nine different regions over time. Optic disc area was measured from single fundus photographs obtained at the beginning of the period of observation.
  
  
  RESULTS
  The open-angle glaucomas were observed for a mean of 6.7 +/- 2.3 years. The number of visual fields per eye was 20.7 +/- 8.0. The mean threshold value of the total field for the first three visual fields was 18.0 +/- 5.2 dB. The visual fields of the 30 eyes with a mean intraocular pressure of 18 +/- 2 mm Hg during follow-up showed a significant decrease in their visual field slope of -0.384 dB/y for the total visual field. On multivariate analysis, the slope or rate of visual field loss was significantly correlated with the average of the first three initial visual field thresholds for the total visual field, temporal, and central regions so that the greater the threshold value the more rapid the rate of the visual field loss. For the total visual field and for the nasal, superior nasal, and temporal regions with lower initial threshold values, the rate of visual field loss was curvilinear with the rate of visual field loss increasing at greater initial mean threshold values. The other regions of the visual field showed a linear increasing rate of visual field loss with larger initial threshold values. Other factors significantly associated with progression of visual field loss were refractive error, race, the slope of the pulse rate, and the mean percent false positives and false negatives for initial to final observations. The mean and the slope of intraocular pressure from initial to final observation were not significant variables.
  
  
  CONCLUSIONS
  In open-angle glaucomas observed for 6.7 +/- 2.3 years, there was a more rapid rate of visual field loss associated with larger initial threshold values and a less rapid rate of visual field loss associated with smaller initial threshold values indicating that the progression of visual field loss is greater in an earlier stage of disease.
authors.affiliation: Glaucoma Research, Inc., Boston, Massachusetts. glaucomares@dreamcom.net
authors.forename: Bernard
authors.initials: B
authors.lastname: Schwartz
authors.forename: Takenori
authors.initials: T
authors.lastname: Takamoto
authors.forename: Jeff
authors.initials: J
authors.lastname: Martin
mesh_terms: D004056:Differential Threshold; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012684:Sensory Thresholds; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D058609:Visual Field Tests; D014794:Visual Fields