title: The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.
abstract: The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.
authors.affiliation: Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Manganelli
authors.forename: Lanfranco
authors.initials: L
authors.lastname: Fattorini
authors.forename: Dejiang
authors.initials: D
authors.lastname: Tan
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Iona
authors.forename: Graziella
authors.initials: G
authors.lastname: Orefici
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Altavilla
authors.forename: Paola
authors.initials: P
authors.lastname: Cusatelli
authors.forename: Issar
authors.initials: I
authors.lastname: Smith
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D005798:Genes, Bacterial; D008168:Lung / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D012808:Sigma Factor / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D014774:Virulence / Q000235:genetics / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D012808:Sigma Factor; D014157:Transcription Factors; C063202:sporulation-specific sigma factors