title: Short-term immunosuppressive therapy does not affect the density of the pre-existing bone around titanium implants placed in rabbits.
abstract: The aim of this study was to evaluate the influence of the administration and withdrawal of cyclosporin A/nifedipine on the bone density in a lateral area adjacent to implants placed in rabbits. Two screw-type titanium implants were placed bilaterally in twenty-eight New Zealand rabbits. The animals were assigned to one of the following groups and received daily subcutaneous injections for 14 days: Groups A and C: vehicle (dimethyl sulfoxide); Groups B and D: CsA (10 mg/kg) plus nifedipine (50 mg/kg). The animals in Groups A and B were sacrificed 14 days postoperatively and, in Groups C and D, 42 days postoperatively. After sacrifice, the tibiae were removed and undecalcified sections were obtained. Bone density was obtained in a 500 mm-wide zone lateral to the implant surface. Intergroup analysis showed no significant difference (p > 0.05) in the degree of bone density between control and test groups either on day 14 or on day 42. Thus, it appears that a short-term immunosuppressive therapy may not present a negative influence on the density of the pre-existing bone around titanium implants placed in rabbits.
authors.affiliation: Department of Prosthodontics and Periodontics, School of Dentistry of Piracicaba, State University of Campinas.
authors.forename: Poliana Mendes
authors.initials: PM
authors.lastname: Duarte
authors.forename: Getúlio Rocha
authors.initials: GR
authors.lastname: Nogueira Filho
authors.forename: Enilson Antônio
authors.initials: EA
authors.lastname: Sallum
authors.forename: Antonio Wilson
authors.initials: AW
authors.lastname: Sallum
authors.forename: Francisco Humberto
authors.initials: FH
authors.lastname: Nociti Júnior
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D004338:Drug Combinations; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D020007:Implants, Experimental; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage; D016348:Osseointegration / Q000502:physiology; D011817:Rabbits; D018709:Statistics, Nonparametric; D013977:Tibia; D014025:Titanium / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D015921:Dental Implants; D004338:Drug Combinations; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D014025:Titanium; D009543:Nifedipine