The selective Na+-Ca2+ exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.
2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400), a specific inhibitor of the Na+-Ca2+ exchanger, exerts cytoprotective action and reduces brain infarct volume after cerebral ischemia. We examined the effect of SEA0400 on vasogenic brain edema in rats. Histological observations showed that radiofrequency current caused brain infarct and extravasation of endogenous albumin in the brain. SEA0400 (3 and 10 mg/kg, i.v.) significantly suppressed the increase in brain water content with attenuation of Evans blue dye and sodium fluorescein extravasation after radiofrequency lesion. The findings suggest that the Na+-Ca2+ exchanger plays a role in vasogenic edema formation after radiofrequency lesion.
Koyama
Yutaka
Y
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Matsui
Shigeo
S
Itoh
Soichi
S
Osakada
Masakazu
M
Baba
Akemichi
A
Matsuda
Toshio
T
D000814:Aniline Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D000818:Animals; D001923:Brain Chemistry; D001929:Brain Edema / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D020520:Brain Infarction / Q000209:etiology / Q000473:pathology; D017115:Catheter Ablation / Q000009:adverse effects*; D005070:Evans Blue / Q000378:metabolism; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000378:metabolism / Q000517:prevention & control; D019793:Fluorescein / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000627:therapeutic use*
D000814:Aniline Compounds; D010647:Phenyl Ethers; C430918:SEA 0400; D012709:Serum Albumin; D019831:Sodium-Calcium Exchanger; D005070:Evans Blue; D019793:Fluorescein