title: General anesthesia and postoperative pain management in analgesic intolerant patients with/without asthma: is it safe?
abstract: BACKGROUND
  Analgesic intolerance (AI) appears in approximately 1 % of the general population. The triad of bronchial asthma, nasal polyposis, and analgesic intolerance is called analgesic-induced asthma (AIA). These patients are frequently referred to adult allergy clinics for preoperative evaluation for possible analgesic cross reactivity and intolerance to anesthetic agents.
  
  
  OBJECTIVE
  To determine allergic problems related to anesthesia and postoperative pain management in AI patients with and without asthma.
  
  
  METHODS
  The medical records of 45 patients who had been diagnosed with AI between January 1991 and December 2002 in the adult allergy unit and who underwent surgery in the same hospital in the last 4 years were retrospectively analyzed.
  
  
  RESULTS
  The mean age of the patients was 44.4 13.4 years and 30 (66.6 %) were female. Thirty-six (80 %) had AIA, 34 (75.6 %) had persistent allergic rhinitis and 21 (46.7 %) had nasal polyps. Fifty-one surgical procedures were performed in 45 patients, in whom ear, nose and throat surgery was the main procedure (64.7 %). Anesthesia was induced with propofol, fentanyl, and vecuronium and was maintained by sevoflurane or isoflurane. Fentanyl was used for early postoperative pain relief. No complications appeared in relation to anesthesia or early pain management except in a 44-year-old AIA woman who had a reaction in the postoperative period after receiving an inappropriate analgesic.
  
  
  CONCLUSIONS
  None of the patients had anesthesia-related allergic problems. Atropine and diazepam in the premedication, propofol and fentanyl during induction, muscle relaxation facilitation by vecuronium, and sevoflurane or isoflurane for maintenance seem to be a safe general anesthetic choice for analgesic intolerant patients with and without asthma.
authors.affiliation: Department of Anesthesiology, Hacettepe University, School of Medicine, Ankara, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Celiker
authors.forename: E
authors.initials: E
authors.lastname: Basgül
authors.forename: G
authors.initials: G
authors.lastname: Karakaya
authors.forename: H
authors.initials: H
authors.lastname: Oguzalp
authors.forename: B
authors.initials: B
authors.lastname: Bozkurt
authors.forename: A F
authors.initials: AF
authors.lastname: Kalyoncu
mesh_terms: D000328:Adult; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000768:Anesthesia, General / Q000379:methods*; D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000008:administration & dosage; D001249:Asthma / Q000139:chemically induced* / Q000150:complications; D001285:Atropine / Q000008:administration & dosage; D003975:Diazepam / Q000008:administration & dosage; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage; D008875:Middle Aged; D009298:Nasal Polyps / Q000150:complications; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D013517:Otorhinolaryngologic Surgical Procedures; D010149:Postoperative Pain / Q000188:drug therapy*; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage; D012189:Retrospective Studies; D000077149:Sevoflurane; D014673:Vecuronium Bromide / Q000008:administration & dosage
chemical_list: D000700:Analgesics; D000777:Anesthetics; D008738:Methyl Ethers; D003473:Neuromuscular Nondepolarizing Agents; D000077149:Sevoflurane; D001285:Atropine; D014673:Vecuronium Bromide; D007530:Isoflurane; D003975:Diazepam; D005283:Fentanyl; D015742:Propofol