title: Bradycardia during therapy for multiple myeloma with thalidomide.
abstract: We studied the medical records of 96 patients who received thalidomide and 104 patients who made up a control group. We found that 53% of patients (52 patients) using thalidomide had a heart rate of <60 beats/min at some point during follow-up and 19% of thalidomide patients (10 patients) developed symptom-related bradycardia. Reducing the thalidomide dose appeared to alleviate symptoms in most patients.
authors.affiliation: Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
authors.forename: Ibrahim Elias
authors.initials: IE
authors.lastname: Fahdi
authors.forename: Venkat
authors.initials: V
authors.lastname: Gaddam
authors.forename: Jorge F
authors.initials: JF
authors.lastname: Saucedo
authors.forename: Channarayapatna V
authors.initials: CV
authors.lastname: Kishan
authors.forename: Keyur
authors.initials: K
authors.lastname: Vyas
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Deneke
authors.forename: Hani
authors.initials: H
authors.lastname: Razek
authors.forename: Brett
authors.initials: B
authors.lastname: Thorn
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Bissett
authors.forename: Elias J
authors.initials: EJ
authors.lastname: Anaissie
authors.forename: Elias
authors.initials: E
authors.lastname: Anaisse
authors.forename: Bart
authors.initials: B
authors.lastname: Barlogie
authors.forename: Jawahar L
authors.initials: JL
authors.lastname: Mehta
mesh_terms: D001919:Bradycardia / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D009101:Multiple Myeloma / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide