title: The most profitable use of flow visualization in the elimination of thrombus from a monopivot magnetic suspension blood pump.
abstract: The purpose of this study was to eliminate fluid dynamic causes of thrombus formation for the monopivot magnetic suspension centrifugal pump under development with the aid of flow visualization as an indirect measurement tool for animal experiments. The formation of thrombus observed in early animal experiments was successfully overcome by combining the multiple washout holes at the center into a single hole, optimizing the hole diameter, and eliminating the pivot gap. Flow visualization was used to optimize the washout hole diameter influencing the flow around the pivot. In animal experiments flow visualization showed that the contours of thrombus corresponded to shear rates of 300 s(-1) or 1300-1700 s(-1). It was found that flow visualization is a useful technique to predict locations where low shear thrombi form and to optimize the pump design in the development stage.
authors.affiliation: National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan. yamane.t@aist.go.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamane
authors.forename: Osamu
authors.initials: O
authors.lastname: Maruyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Masahiro
authors.initials: M
authors.lastname: Toyoda
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Tsutsui
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Jikuya
authors.forename: Osamu
authors.initials: O
authors.lastname: Shigeta
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sankai
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002498:Centrifugation; D004867:Equipment Design; D006353:Heart-Assist Devices; D018056:Hemorheology / Q000379:methods*; D012756:Sheep; D013927:Thrombosis / Q000517:prevention & control*