title: Pentacyclic triterpenoids and their cytotoxicity from the stem bark of Styrax japonica S. et Z.
abstract: The methylene chloride soluble fraction of MeOH extract from the stem bark of Styrax japonica S. et Z. (Styracaceae) showed significant cytotoxicity by SRB method against five human tumor cell lines. Four known pentacyclic triterpenoids, oleanolic aldehyde acetate (1), erythrodiol-3-acetate (2), euphorginol (3), and anhydrosophoradiol-3-acetate (4) were isolated by activity-guided fractionation. Their structures were determined by chemical and spectral analysis. Compounds 1-4 were isolated from S. japonica for the first time.
authors.affiliation: Research Center for Proteineous Materials, Chosun University, Gwangju 501-759, Korea.
authors.forename: Mi-Ran
authors.initials: MR
authors.lastname: Kim
authors.forename: Hyang-Hee
authors.initials: HH
authors.lastname: Lee
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Hahm
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Moon
authors.forename: Eun-Rhan
authors.initials: ER
authors.lastname: Woo
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems; D032362:Styrax; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D010936:Plant Extracts; D014315:Triterpenes