Medical treatment of stage I nasal polyposis over a 3-year follow-up period.
OBJECTIVE
To determine the effects of a standardized therapeutic protocol (short-term oral administration of prednisolone and daily intranasal spray of beclometasone) on stage I nasal polyposis over a follow-up period of 3 years.


METHODS
Assessments (evaluation of nasal function and drug consumption) were conducted at baseline and every 3 months on 54 consecutive patients with stage I nasal polyposis during 3 years.


RESULTS
Over the follow-up period of 3 years, this dual modality proved to be successful in 87% of the subjects; only 13% had to undergo surgery after its failure. The average symptom reduction reached an improvement rate varying from 66 to 94.8%, according to the symptom type. The daily dosage of prednisolone and beclometasone was progressively decreased, while the gain in nasal comfort was being preserved.


CONCLUSIONS
Management of stage I nasal polyps should be primarily medical.
Bonfils
Pierre
P
Department of Otolaryngology, ENT Research Laboratory, European Hospital Georges Pompidou, University Paris V, FR-75015 Paris, France. pierre.bonfils@egp.ap-hop.paris.fr
Norès
Jean-Marc
JM
Halimi
Philippe
P
Avan
Paul
P
D000281:Administration, Intranasal; D000284:Administration, Oral; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index; D007507:Therapeutic Irrigation; D013997:Time Factors; D016896:Treatment Outcome
D005938:Glucocorticoids; D011239:Prednisolone; D001507:Beclomethasone