Use of polypharmacotherapy in pregnancy: a prospective outcome in a case.
OBJECTIVE
Little is known about the risks associated with prenatal exposure to atypical antipsychotics. Our objective is to present a case of exposure to risperidone and quetiapine in pregnancy, and additionally to some other drugs.


METHODS
Our case (36-year old) has suffered schizophrenia (DSM-IV) for 5 years and used these drugs (risperidone, quetiapine, mirtazapine, thioridazine, diazepam, hydroxyzine, clomipramine, fluvoxamine, alprazolam, carbamazepine, biperiden, haloperidol, ampicillin+sulbactam, enoxaparin, oxerutine) in her third pregnancy. Because of her psychotic condition, Mrs. N.B. was not aware of her pregnancy until 22nd week and the pregnancy could not be terminated. She had a female infant (3000 g, 50 cm) with APGAR scores of 8-9 at the first and fifth minutes at 37th week with an uncomplicated vaginal delivery. The baby was normal.


CONCLUSIONS
This case may contribute to the existing knowledge regarding use of atypical antipsychotics in pregnancy.
Yaris
Fusun
F
Department of Family Medicine, Karadeniz Technical University School of Medicine, Trabzon TR 61187, Turkey. fyaris@meds.ktu.edu.tr
Yaris
Ersin
E
Kadioglu
Mine
M
Ulku
Cunay
C
Kesim
Murat
M
Kalyoncu
Nuri Ihsan
NI
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001034:Apgar Score; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000523:psychology*; D011256:Pregnancy Outcome; D000069348:Quetiapine Fumarate; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate; D018967:Risperidone