title: Pulmonary function and sputum production in patients with cystic fibrosis: a pilot study comparing the PercussiveTech HF device and standard chest physiotherapy.
abstract: OBJECTIVE
  To compare the PercussiveTech HF (PTHF) device (Vortran Medical Technology 1; Sacramento, CA) to standard manual chest physiotherapy (CPT) with respect to acute changes in pulmonary function, sputum production, and pulse oximetry in patients with cystic fibrosis (CF).
  
  
  METHODS
  Randomized crossover.
  
  
  METHODS
  University-affiliated, community-based CF center.
  
  
  METHODS
  Ten clinically stable patients with CF (age range, 10 to 21 years; mean age, 15.3 years) with Shwachman scores from 55 to 95 (mean 75).
  
  
  METHODS
  Two treatment regimens were used: 2.5 mg of albuterol delivered via updraft nebulizer followed by standard CPT, and 2.5 mg of albuterol delivered via the PTHF device without CPT.
  
  
  RESULTS
  Outcome measures included pulmonary function test (PFT) results 4 h after treatment and quantitative sputum production during the 4 h after treatment. Pulse oximetry was performed during treatment. A patient satisfaction questionnaire was administered at the end of the study. No PFT parameters were significantly changed 4 h after CPT or PTHF, although there was a trend to decreasing residual volume after both treatments. There was a trend for more sputum production after PTHF compared to CPT, but this did not reach statistical significance. There were no episodes of hemoglobin-oxygen desaturation during or after either treatment. One patient had minor hemoptysis after CPT. No adverse effects occurred after PTHF. Eight patients found the PTHF device easy to use, and six patients would prefer the PTHF device to CPT.
  
  
  CONCLUSIONS
  The PTHF device appears to be a safe and effective method of airway clearance in CF patients in this small pilot study.
authors.affiliation: Pediatric Pulmonary Division, Department of Pediatrics, Michigan State University, Kalamazoo Center for Medical Studies, MI 49008, USA. marks@kcms.msu.edu
authors.forename: John H
authors.initials: JH
authors.lastname: Marks
authors.forename: Karyl L
authors.initials: KL
authors.lastname: Hare
authors.forename: Robert A
authors.initials: RA
authors.lastname: Saunders
authors.forename: Douglas N
authors.initials: DN
authors.lastname: Homnick
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage; D001993:Bronchodilator Agents / Q000008:administration & dosage; D002648:Child; D018592:Cross-Over Studies; D003550:Cystic Fibrosis / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D010092:Oximetry; D017060:Patient Satisfaction; D010474:Percussion; D010865:Pilot Projects; D012129:Respiratory Function Tests; D012138:Respiratory Therapy / Q000379:methods*; D013183:Sputum / Q000378:metabolism*; D016896:Treatment Outcome; D012122:Ventilators, Mechanical
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D000420:Albuterol