IgG- and IgE-mediated antigen presentation on MHC class II.
IgG- and IgE-antibodies have the ability to enhance the production of antibodies directed against the antigen they are specific for. It has been suggested that the mechanism behind IgG- and IgE-mediated feedback enhancement is the ability of these isotypes to induce a more potent antigen-specific T helper cell response, increasing the chances that antigen-specific B cells receive the T cell help they require to become antibody-producing cells. With emphasis on the murine system, we will here focus on the ability of IgG and IgE to capture antigen and facilitate presentation of antigenic peptides to T helper cells. Whether this mechanism underlies feedback enhancement of antibody responses to these antigens will be discussed.
Getahun
Andrew
A
Department of Genetics and Pathology, Uppsala University, Uppsala SE-751 85, Sweden. andrew.getahun@genpat.uu.se
Heyman
Birgitta
B
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G; D007073:Immunoglobulin E