title: Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.
abstract: A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity.
authors.affiliation: Department of Chemistry, Kosan Biosciences Inc, 3832 Bay Center Place, Hayward, CA 94545, USA. burlingame@kosan.com
authors.forename: Mark A
authors.initials: MA
authors.lastname: Burlingame
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Shaw
authors.forename: Kurt F
authors.initials: KF
authors.lastname: Sundermann
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Joseph
authors.initials: J
authors.lastname: Petryka
authors.forename: Esteban
authors.initials: E
authors.lastname: Mendoza
authors.forename: Fenghua
authors.initials: F
authors.lastname: Liu
authors.forename: David C
authors.initials: DC
authors.lastname: Myles
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: LaMarche
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Hirose
authors.forename: B
authors.initials: B
authors.lastname: Scott Freeze
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011753:Pyrones
chemical_list: D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007783:Lactones; D011753:Pyrones; C071229:discodermolide