title: Light traffic: photo-crosslinking a novel transport system.
abstract: The Tat protein transporter is found in the membranes of many bacteria and in plant chloroplasts. This highly unusual transport machine moves folded and often oligomeric substrate proteins across energy-conserving membranes. A recent paper reports the first use of a photo-crosslinking approach to dissect the early recognition events between the transporter and its substrate.
authors.affiliation: Department of Molecular Microbiology, John Innes Centre, Norwich, UK. tracy.palmer@bbsrc.ac.uk
authors.forename: Tracy
authors.initials: T
authors.lastname: Palmer
authors.forename: Frank
authors.initials: F
authors.lastname: Sargent
authors.forename: Ben C
authors.initials: BC
authors.lastname: Berks
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D001120:Arginine / Q000378:metabolism; D001419:Bacteria / Q000166:cytology; D001426:Bacterial Proteins / Q000378:metabolism; D001692:Biological Transport; D002736:Chloroplasts / Q000378:metabolism; D016384:Consensus Sequence; D003432:Cross-Linking Reagents / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism; D015696:Gene Products, tat / Q000378:metabolism*; D008027:Light; D008239:Lysine / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D010940:Plant Proteins / Q000378:metabolism; D017510:Protein Folding; D021382:Protein Sorting Signals; D021381:Protein Transport / Q000235:genetics; D013379:Substrate Specificity; D020524:Thylakoids / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D003432:Cross-Linking Reagents; D029968:Escherichia coli Proteins; D015696:Gene Products, tat; D026901:Membrane Transport Proteins; D010940:Plant Proteins; D021382:Protein Sorting Signals; D001120:Arginine; D008239:Lysine