title: Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down.
abstract: The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake (VO2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen (vWf:Ag), tissue plasminogen activator (tPA) antigen and activity and plasminogen activator inhibitor-1 (PAI-1) activity. Data were analyzed using repeated measures analysis of variance. No significant differences were found between VO2max tests for treadmill time, VO2max, respiratory exchange ratio, maximal heart rate, or maximal blood lactate concentration. vWf:Ag was significantly elevated (P <0.05)following PC [198.4 (18.3)% normal] versus AC [174.5 (15.6)% normal] and remained elevated 1-h post-exercise [179.4 (16.4)% normal for PC vs 158.6 (13.8)% normal for AC]. There were no differences between tests for tPA or PAI-1 activity, although tPA antigen was significantly elevated following PC versus AC (P <0.05). Following the cool-down, hematocrit was higher (P <0.05) for the PC test [48.90 (0.36)] compared with AC [47.43 (0.51)]. An AC reduces post-exercise vWf:Ag and tPA antigen without affecting tPA or PAI-1 activity.
authors.affiliation: Human Energy Research Laboratory, Department of Kinesiology, Michigan State University, East Lansing, MI 48824, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Paton
authors.forename: P R
authors.initials: PR
authors.lastname: Nagelkirk
authors.forename: A M
authors.initials: AM
authors.lastname: Coughlin
authors.forename: J A
authors.initials: JA
authors.lastname: Cooper
authors.forename: G A
authors.initials: GA
authors.lastname: Davis
authors.forename: H
authors.initials: H
authors.lastname: Hassouna
authors.forename: J M
authors.initials: JM
authors.lastname: Pivarnik
authors.forename: C J
authors.initials: CJ
authors.lastname: Womack
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D000941:Antigens / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000379:methods; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D020127:Recovery of Function / Q000502:physiology; D012420:Running / Q000502:physiology*; D010959:Tissue Plasminogen Activator / Q000037:antagonists & inhibitors / Q000097:blood*; D014841:von Willebrand Factor / Q000276:immunology
chemical_list: D000941:Antigens; D017395:Plasminogen Activator Inhibitor 1; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D010959:Tissue Plasminogen Activator