Interleukin 10-2849AA genotype protects against pre-eclampsia.
Recently, it has been described that human fertility is associated with the interleukin 10 (IL10) -2849 AA genotype. Pre-eclampsia is the most common pregnancy-specific complication. In the pathogenesis of pre-eclampsia, IL10 may affect maternal intravascular inflammation as well as endothelial dysfunction. Therefore, we tested the hypothesis that pre-eclampsia is associated with genetic variation in the IL10 promoter region in a case-control study for pre-eclampsia. Women homozygous for the IL10 -2849A allele have a threefold reduced risk for pre-eclampsia compared to controls (odds ratio 0.29; 95% CI 0.10-0.83). No differences in genotype frequency were found for polymorphisms in the IL10 promoter region at positions -1082, -819 and -592. This suggests that there is a genetically determined mechanism which protects the mother against pre-eclampsia, as reflected in the lower frequency of the IL10 -2849AA genotype in pre-eclamptic women.
de Groot
C J M
CJ
1Department of Obstetrics and Gynecology, Erasmus Medical Center Rotterdam, The Netherlands.
Jansen
M W J C
MW
Bertina
R M
RM
Schonkeren
J J M
JJ
Helmerhorst
F M
FM
Huizinga
T W J
TW
D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006720:Homozygote; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D011401:Promoter Regions, Genetic
D016753:Interleukin-10