[Effect of long-term therapy with transdermal patches releasing glyceryl trinitrate (GTN) used in pregnant hypertensive women on stabilisation of blood pressure and on the condition of the newborn infant].
OBJECTIVE
An observation of an influence of long-term therapy of pregnant women affected by arterial hypertension with transdermal patches releasing GTN on stabilisation of blood pressure and newborn condition.


METHODS
The transdermal patches (Minitran S10) releasing GTN were used for the treatment of 27 pregnancies between 27-34 weeks admitted for hypertension above 150/100 mmHg. The average period of obtaining the proper blood pressure values, time of therapy, side effects of treatment and effects of nitrate tolerance were assessed. After delivery the newborns condition were estimated by Apgar score and their trophy was assessed after the centile chart.


RESULTS
The diminishing of mean blood pressure values in range 135/85 mmHg was received after 8 to 48 hours of treatment in 25 of the examined women. The time of therapy was from 3 to 13 weeks without any serious side effects besides transient headaches eliminated by application of oral analgesic drugs. 24 newborns were delivered in good conditions--8-9 Apgar score. No side effects of long-term therapy with patches releasing GTN were observed among the newborns.


CONCLUSIONS
The long-term transdermal treatment afford possibilities for pregnancy prolongation until the term of delivery and improves the foetal development conditions. The side effects of treatment are transient and affected only mothers.
Brzozowska
Maria
M
Kliniki Patologii Ciazy Instytutu Ginekologii i Połoznictwa UM w Łodzi.
Kowalska-Koprek
Urszula
U
Karowicz-Bilińska
Agata
A
Pajszczyk-Kieszkiewicz
Teresa
T
D000279:Administration, Cutaneous; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006261:Headache / Q000139:chemically induced; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy* / Q000517:prevention & control; D011256:Pregnancy Outcome; D011263:Pregnancy Trimester, Third; D013997:Time Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D005996:Nitroglycerin