title: Behavioral symptoms in mild cognitive impairment.
abstract: The authors investigated neuropsychiatric symptoms in mild cognitive impairment (MCI) from baseline data of the Investigation in the Delay to Diagnosis of AD with Exelon (InDDEx) study (n = 1,010). Neuropsychiatric symptoms were reported in 59% of subjects (Neuropsychiatric Inventory [NPI]). NPI+ subjects had significantly greater impairment on global, cognitive, and functional scores than NPI- subjects. The presence of neuropsychiatric symptoms appears to be a marker of MCI severity.
authors.affiliation: Division of Neurology, University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia, Canada. hfeldman@interchange.ubc.ca
authors.forename: H
authors.initials: H
authors.lastname: Feldman
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
authors.forename: E
authors.initials: E
authors.lastname: Scarpini
authors.forename: N
authors.initials: N
authors.lastname: Hermann
authors.forename: P
authors.initials: P
authors.lastname: Mesenbrink
authors.forename: L
authors.initials: L
authors.lastname: Mancione
authors.forename: S
authors.initials: S
authors.lastname: Tekin
authors.forename: R
authors.initials: R
authors.lastname: Lane
authors.forename: S
authors.initials: S
authors.lastname: Ferris
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology / Q000517:prevention & control*; D001526:Behavioral Symptoms / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D002219:Carbamates / Q000627:therapeutic use; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D048448:Phenylcarbamates; D000068836:Rivastigmine
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D048448:Phenylcarbamates; D000068836:Rivastigmine