title: Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease.
abstract: The N-terminal aminoacid of phenethylamide tripeptide inhibitors of the hepatitis C virus NS3 protease can be replaced with an alpha-hydroxy acid to obtain more 'drug like' inhibitors with low micromolar activity. The preferred S-configuration of the capping residue can be explained by molecular modeling studies.
authors.affiliation: Department of Chemistry, IRBM, MRL Rome, Via Pontina Km 30,600, 00040 Pomezia, Rome, Italy.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Nizi
authors.forename: Uwe
authors.initials: U
authors.lastname: Koch
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Ontoria
authors.forename: Antonella
authors.initials: A
authors.lastname: Marchetti
authors.forename: Frank
authors.initials: F
authors.lastname: Narjes
authors.forename: Savina
authors.initials: S
authors.lastname: Malancona
authors.forename: Victor G
authors.initials: VG
authors.lastname: Matassa
authors.forename: Cristina
authors.initials: C
authors.lastname: Gardelli
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000577:Amides; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases