title: Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum.
abstract: The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively.
authors.affiliation: Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. vinod.hedge@spcorp.com
authors.forename: Vinod R
authors.initials: VR
authors.lastname: Hegde
authors.forename: Haiyan
authors.initials: H
authors.lastname: Pu
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Todd
authors.initials: T
authors.lastname: Black
authors.forename: Aileen
authors.initials: A
authors.lastname: Soriano
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhao
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Gullo
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D019915:DNA Primase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045468:Fallopia japonica / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D019915:DNA Primase