New diterpenes from Croton insularis.
Two new diterpenes (1 and 2) have been isolated from the aerial parts of Croton insularis. Their structures have been established by NMR and mass spectral data, and the absolute configuration of 1 and related trachylobane diterpenes was determined through a series of chemical correlations.
Graikou
Konstantia
K
Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece.
Aligiannis
Nektarios
N
Skaltsounis
Alexios-Léandros
AL
Chinou
Ioanna
I
Michel
Sylvie
S
Tillequin
François
F
Litaudon
Marc
M
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D015394:Molecular Structure; D009510:New Caledonia; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C485924:crotinsularin; C485923:ent-trachyloban-3-one