Comparison of Gd DTPA-BMA (Omniscan) versus Gd HP-DO3A (ProHance) retention in human bone tissue by inductively coupled plasma atomic emission spectroscopy.
OBJECTIVE
Human bone tissue was collected following administration of a clinical dose of gadolinium chelate (0.1 mmol per kg) to patients undergoing hip joint replacement surgery to determine if measurable differences in Gd deposition occur between 2 widely available magnetic resonance contrast agents.


METHODS
Gd HP-DO3A (ProHance), Gd DTPA-BMA (Omniscan), and an age-matched control population without history of gadolinium chelate administration were compared. Bone samples were collected fresh, placed in refrigeration, and subsequently frozen. Tissue digestion was performed using a microwave tissue digester and concentrated nitric acid. A method of tissue analysis was created for gadolinium using inductivity coupled plasma atomic emission spectroscopy (ICP-AES).


RESULTS
Tissue retention was 1.18 +/- .787 microg Gd/g bone (N = 10) for Omniscan and 0.466 +/- .387 microg Gd/g bone (N = 8) for ProHance measured by ICP-AES.


CONCLUSIONS
Omniscan (Gd DTPA-BMA) left 2.5 times more Gd behind in bone than did ProHance (Gd HP-DO3A).
Gibby
Wendell A
WA
Riverwoods Advanced Imaging Center, Provo, Utah 84604, USA. wgibby@novared.net
Gibby
Krissa A
KA
Gibby
W Andrew
WA
D000368:Aged; D003287:Contrast Media / Q000378:metabolism / Q000493:pharmacokinetics*; D005270:Femur Head / Q000737:chemistry* / Q000378:metabolism; D005682:Gadolinium / Q000032:analysis* / Q000378:metabolism; D019786:Gadolinium DTPA / Q000378:metabolism / Q000493:pharmacokinetics*; D006571:Heterocyclic Compounds / Q000378:metabolism / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D009942:Organometallic Compounds / Q000378:metabolism / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013054:Spectrophotometry, Atomic / Q000379:methods
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; C064925:gadodiamide; D005682:Gadolinium; D019786:Gadolinium DTPA