title: [Immunotoxicologic assessment of transgenetic rice].
abstract: OBJECTIVE
  To assess the immunotoxicologic aspect of transgenetic plant.
  
  
  METHODS
  BALB/C mice were fed with food composed by transgenic rice (into which cowpea trypsin inhibitor gene was introduced) or nontransgenetic rice (which has the same gene composition as the transgenic rice except for the cowpea trypsin inhibitor gene) for 30 days. All food is made according to the composition of AIN-93G. In the end, all kinds of immunotoxicologic indexes of mice of every group were compared such as body weight, guts index, blood routine test, lymphocyte sort, serum antibody titter, plaque forming cell, delayed hypersensitivity response, macrophage function test.
  
  
  RESULTS
  All immunotoxicologic indexes of mice fed either by transgenic rice or nontransgenetic rice have no differences to those of mice fed by normal food.
  
  
  CONCLUSIONS
  Transgenic rice is substantially equivilent to nontransgenetic rice in immunotoxicologic aspect.
authors.affiliation: Institute of Nutrition and Food safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhuo
authors.forename: Jianhua
authors.initials: J
authors.lastname: Piao
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012275:Oryza / Q000235:genetics* / Q000633:toxicity; D018532:Pisum sativum / Q000235:genetics; D010940:Plant Proteins / Q000235:genetics*; D030821:Plants, Genetically Modified / Q000633:toxicity*; D011897:Random Allocation; D013601:T-Lymphocytes / Q000276:immunology; D014361:Trypsin Inhibitors; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
chemical_list: D016827:CD8 Antigens; D010940:Plant Proteins; D014361:Trypsin Inhibitors; D000516:alpha-Amylases