title: Further labdane and kaurane diterpenoids and other constituents from Plectranthus fruticosus.
abstract: Eight new diterpenoids, one labdane and seven kaurane derivatives, and a new aromadendrane-type sesquiterpenoid have been isolated from the most polar chromatographic fractions of an acetone extract of Plectranthus fruticosus. The structures of the new compounds (1-9) were established mainly by 1D and 2D NMR studies and by some chemical transformations. Compounds 6 and 8 were characterized as their methyl ester derivatives (13 and 14, respectively). Most of the isolated compounds and some of their derivatives were tested as antimicrobial agents, but only 19 showed moderate inhibitory activity against Staphylococcus aureus.
authors.affiliation: Faculdade de Farmácia da Universidade de Lisboa, Centro de Estudos de Ciências Farmacêuticas, Avenida das Forças Armadas, 1649-019 Lisbon, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Gaspar-Marques
authors.forename: M Fátima
authors.initials: MF
authors.lastname: Simões
authors.forename: Benjamín
authors.initials: B
authors.lastname: Rodríguez
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031346:Plectranthus / Q000737:chemistry*; D011174:Portugal; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D045786:Diterpenes, Kaurane