Synthesis and immunomodulatory properties of selected oxazolone derivatives.
Eleven oxazolone derivatives were synthesized and characterized by (1)H NMR, EI, IR and UV spectroscopic and CHN analysis. Three compounds, 4-[(E)-(4-nitrophenyl)methylidene]-2-phenyl-1,3-oxazol-5(4H)-one (11), 4-[(E)-(4-methoxyphenyl)methylidene]-2-methyl-1,3-oxazol-5-one (12) and 4-[(E)-(4-nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) were screened for phagocyte chemiluminescence, neutrophil chemotaxis, T-cell proliferation, cytokine production from mononuclear cells and cytotoxicity. 4-[(E)-(4-Nitrophenyl)methylidene]-2-methyl-1,3-oxazol-5(4H)-one (13) was found to be the most potent immunomodulator in the series.
Mesaik
Muhammad A
MA
Department of Microbiology, University of Karachi, Karachi 75270, Pakistan.
Rahat
Shagufta
S
Khan
Khalid M
KM
Zia-Ullah
Choudhary
Muhammad I
MI
Murad
Shahnaz
S
Ismail
Zakiah
Z
Atta-ur-Rahman
Ahmad
Aqeel
A
D000818:Animals; D002417:Cattle; D002455:Cell Division; D002478:Cells, Cultured; D007155:Immunologic Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
D007155:Immunologic Factors; D010080:Oxazoles