title: Intra-arterial administration of sodium borocaptate (BSH)/lipiodol emulsion delivers B-10 to liver tumors highly selectively for boron neutron capture therapy: experimental studies in the rat liver model.
abstract: OBJECTIVE
  Boron neutron capture therapy (BNCT) is particle radiotherapy with alpha ((4)He) particle and recoiled lithium nucleus ((7)Li) derived from a reaction of boron ((10)B) and thermal neutron. We investigated applying BNCT to malignant liver tumors. The purpose of the present study was to reveal the efficacy for administration of emulsion of a boron compound (sodium borocaptate; BSH) and lipiodol via a hepatic artery using a rat liver tumor model.
  
  
  METHODS
  Rat liver tumors were developed by direct injection of Walker 256 cells into the liver parenchyma. BSH (75 mg/kg)/lipiodol (0.3 mL/kg) emulsion was administered via the hepatic artery. Boron concentrations in the tumors, liver, and blood were measured at 1, 6, and 12 h after administration. Neutron capture radiography (NCR) was taken to confirm the selective accumulation of (10)B in the liver tumors.
  
  
  RESULTS
  Boron concentrations in the liver tumors and the tumor/liver (T/L) boron concentration ratio at 1, 6, and 12 h after administration of BSH/lipiodol emulsion (concentration: T/L ratio) were 479.2 ppm: 4.0, 197.3 ppm: 14.9, and 96.5 ppm: 6.6, respectively. Highly selective irradiation was clearly demonstrated by the NCR images.
  
  
  CONCLUSIONS
  Intra-arterial administration of BSH/lipiodol emulsion is effective method for delivering high concentration of (10)B selectively to the liver tumors.
authors.affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, Kyoto, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Masunaga
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kinashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagata
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Nakamatsu
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002279:Carcinoma 256, Walker / Q000378:metabolism / Q000532:radiotherapy*; D003287:Contrast Media / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006499:Hepatic Artery; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008094:Lithium / Q000008:administration & dosage / Q000493:pharmacokinetics; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000532:radiotherapy*; D051381:Rats; D017208:Rats, Wistar; D013438:Sulfhydryl Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D001894:Borohydrides; D003287:Contrast Media; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D007459:Iodized Oil; D008094:Lithium