title: The influence of anatomic location on functional outcome in lower-extremity soft-tissue sarcoma.
abstract: BACKGROUND
  The purpose of this study was to explore the relationship between the anatomical location of lower-extremity soft-tissue sarcoma and functional outcome.
  
  
  METHODS
  Function was evaluated with the Musculoskeletal Tumor Society (MSTS 1993) score and Toronto Extremity Salvage Score (TESS); 207 patients (median age, 54 years) were eligible. The median maximum tumor diameter was 8.0 cm; 58 tumors were superficial and 149 were deep. Nine locations based on anatomical compartments were defined: 6 tumors were in the groin/femoral triangle; 8, the buttock; 52, the anterior thigh; 22, the medial thigh; 20, the posterior thigh; 10, the popliteal fossa; 13, the posterior calf; 11, the anterolateral leg; and 7, the foot or ankle.
  
  
  RESULTS
  Treatment of superficial tumors did not lead to significant changes in MSTS score (mean, 90.6% preoperatively vs. 93.0% postoperatively; P =.566) or TESS (mean, 86.4% preoperatively vs. 90.9% postoperatively; P =.059). Treatment of deep tumors lead to significant reductions in MSTS score and TESS (mean MSTS, 86.9% preoperatively vs. 83.0% postoperatively; P =.001; and mean TESS, 83.0% preoperatively vs. 79.4% postoperatively; P =.015). Anatomical location was not a significant predictor of aggregated MSTS and TESS evaluations. Exploratory analysis showed variation in MSTS pain and gait handicap or limp items and TESS dressing, sitting, bending, and bathing items by anatomical location.
  
  
  CONCLUSIONS
  The treatment of superficial tumors does not lead to significant changes in MSTS score or TESS. Anatomical location is not a significant predictor of aggregated MSTS and TESS evaluations. However, there is variation in MSTS and TESS item scores across anatomical locations.
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada.
authors.forename: C H
authors.initials: CH
authors.lastname: Gerrand
authors.forename: J S
authors.initials: JS
authors.lastname: Wunder
authors.forename: R A
authors.initials: RA
authors.lastname: Kandel
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: C N
authors.initials: CN
authors.lastname: Catton
authors.forename: R S
authors.initials: RS
authors.lastname: Bell
authors.forename: A M
authors.initials: AM
authors.lastname: Griffin
authors.forename: A M
authors.initials: AM
authors.lastname: Davis
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D007866:Leg / Q000033:anatomy & histology* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012307:Risk Factors; D012509:Sarcoma / Q000473:pathology / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome