title: [Refractory germ cell cancer of testis treated by salvage high-dose chemotherapy: report of three cases].
abstract: We reported three cases (42, 20 and 18-year-old men) of advanced nonseminomatous testicular germ cell cancer treated by salvage high-dose chemotherapy (HDC) supported by peripheral blood stem cell autotransplantation. Two cases which had been refractory to (B) EP (bleomycin, etoposide, cisplatin) and VIP (etoposide, ifosfmide, cisplatin) chemotherapies received one course of high-dose CEI (carboplatin 1,250 mg/m2, etoposide 1,500 mg/m2 and ifosfamide 7.5 g/m2), and the other case had been refractory to PVB (cisplatin, vinblastine, bleomycin) and VIP chemotherapies received one course of high-dose CEI and high-dose CCT (carboplatin 800 mg/m2, cyclophosphamide 6 g/m2 and thiotepa 720 mg/m2). Only one case achieved an incomplete remission by HDC, which was verified as a pathological complete response at the following salvage surgery, and has been alive with no evidence of disease for 68 months. The others achieved no change of disease following HDC and died from cancer progression. Hepatotoxicity, neurotoxicity and severe depression occurred, but not fatal in 2 cases.
authors.affiliation: Department of Urology, Iwate Medical University School of Medicine.
authors.forename: Susumu
authors.initials: S
authors.lastname: Tanji
authors.forename: Wataru
authors.initials: W
authors.lastname: Obara
authors.forename: Jun
authors.initials: J
authors.lastname: Sugimura
authors.forename: Sou
authors.initials: S
authors.lastname: Ohmori
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Matsushita
authors.forename: Hideo
authors.initials: H
authors.lastname: Tokunaga
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Konda
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujioka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Murai
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ishida
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D018237:Germinoma / Q000628:therapy*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D011379:Prognosis; D016879:Salvage Therapy; D013736:Testicular Neoplasms / Q000628:therapy*; D013852:Thiotepa / Q000008:administration & dosage; D014182:Transplantation, Autologous; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D003520:Cyclophosphamide; D013852:Thiotepa; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide