title: New chromanone acids with antibacterial activity from Calophyllum brasiliense.
abstract: Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with 1 and 2 being most active. None of the compounds were cytotoxic against KB, Jurkat T, and myosarcoma cancer cells up to 20 microg/mL.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, University of Cagliari, 09124 Cagliari, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Cottiglia
authors.forename: Boopathy
authors.initials: B
authors.lastname: Dhanapal
authors.forename: Otto
authors.initials: O
authors.lastname: Sticher
authors.forename: Jörg
authors.initials: J
authors.lastname: Heilmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects; D029759:Calophyllum / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019169:Jurkat Cells; D007624:KB Cells; D013058:Mass Spectrometry; D008800:Mexico; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002867:Chromones