Artificially induced polymer particle erosion of oral hydrocolloid systems by the addition of insoluble cellulose fibres to fibre-free methylhydroxy ethylcellulose (MHEC).
The erosion-controlled drug release from different methylhydroxy ethylcellulose (MHEC) hydrocolloid tablets was examined. The special polymer particle erosion mechanism, which is nearly independent from the hydrodynamic conditions in the dissolution medium, could be attributed to the existence of insoluble fibres within the polymer material. They could be identified via microscopic analysis. The study presents a precipitation method, which guarantees an appropriate incorporation of insoluble microcrystalline cellulose fibres into fibre-free MHEC material. This method leads to a manufacturing process for polymer particle erosion-controlled hydrocolloid systems with the possibility to adjust the drug release rate.
Freichel
Oliver L
OL
Institut für Pharmazeutische Technologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
Lippold
Bernhard C
BC
D000284:Administration, Oral; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*; D003102:Colloids / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D010316:Particle Size; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D012995:Solubility / Q000187:drug effects
D003102:Colloids; D011108:Polymers; C013517:ethyl cellulose; D002482:Cellulose