[Changes of biogenic amines in the thymus cell system after T-activin administration].
The aim of this work was to study the dynamics of the neurotransmitter (cateholamine, serotonin, histamine) content in the thymic structures, as well as of heparin maturation degree and degranulation in the thymic mast cells population by means of Falck, Cross and Unna luminescent-histochemical methods 1-30 days following daily T-activinum injections. Concentration of the neurotransmitters in all the bioamine-containing thymic structures was found to fall by day 7, but after day 14 it began to increase, reaching a high level by day 30 that significantly exceeded the initial values. The degree of heparin maturation in mast cells was increased at days 21 and 30. Long-term T-activinum administration (for more than 7 days) is not justified, since an excessive increase in bioamine and heparin content suppresses immune reactions. Degranulating mast cells, surrounded by the zones of microenvironment, that were saturated with the bioamines capable of suppressing thymocytes, were found to predominate at the late stages of an experiment with T-activinum injections.
Iastrebova
S A
SA
Department of Medical Biology, I.N. Ulyanov Chuvash State University, Cheboksary.
Sergeeva
V E
VE
Spirin
I V
IV
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D015550:Cell Degranulation / Q000187:drug effects*; D007273:Injections, Intramuscular; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013949:Thymus Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D001679:Biogenic Amines; D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin