[Kinetics of liberation of the theophylline in semi-solid matrix based of Gelucire].
Dissolution of a tracer included in Gelucire is primarily governed by two physico-chemical nominative parameters of this auxiliary substance which are its melting point and its hydrophily-lypophily balance. As they are not dissociable and their interaction is very significant, the optimisation of a formulation containing a mix of Gelucire cannot be done with polynomial models. An indirect modelisation, as Simplex, is however possible.
Ortigosa
Cl A
CA
Laboratoire de pharmacie galénique, pharmacotechnie et biopharmacie, Faculté de pharmacie, B.P. 14491, 15, avenue Charles Flahault, F34093 Montpellier Cedex 5.
Lasserre
Y J
YJ
D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D005079:Excipients; D005782:Gels; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry
D001993:Bronchodilator Agents; D005079:Excipients; D005782:Gels; D013806:Theophylline