title: Endothelial injury in peritoneal dialysis patients with ultrafiltration failure.
abstract: To evaluate endothelial injury in peritoneal dialysis patients with ultrafiltration failure (UFF), we performed a modified peritoneal equilibration test utilizing 3.86% glucose in 41 patients who had been on peritoneal dialysis for longer than 4 years. Twelve patients whose net ultrafiltrate was less than 400 mL during a 4-hour exchange were assigned to the UFF group and another 29 patients to the control group. The blood levels of vWF, a marker of endothelial injury, albumin, and lipid profile were measured. The number of antihypertensive medications and amount of 3.86% solution used were higher in the UFF group than those used in the control group (p < 0.05, p < 0.001, respectively). The patients in the UFF group had a significantly higher vWF level than those in the control group (164.8 +/- 23.1% vs. 144.5 +/- 22.4%, p < 0.05). These results showed that peritoneal dialysis patients with ultrafiltration failure had more severe endothelial injury than those without.
authors.affiliation: Department of Internal Medicine, Asian Medical Center, College of Medicine, University of Ulsan, Seoul, South Korea. sbkim@amc.seoul.kr
authors.forename: Soon Bae
authors.initials: SB
authors.lastname: Kim
authors.forename: Sang Koo
authors.initials: SK
authors.lastname: Lee
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D012709:Serum Albumin / Q000378:metabolism; D017211:Treatment Failure; D014462:Ultrafiltration; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D008055:Lipids; D012709:Serum Albumin; D014841:von Willebrand Factor