Intra-arterial steroid-injection therapy for steroid-refractory acute graft-versus-host disease with the evaluation of angiography.
We treated three patients with steroid-refractory acute graft-versus-host disease (aGVHD) with intra-arterial steroid-injection therapy (IAST). Two patients with gut aGVHD received IAST into both superior and inferior mesenteric arteries, while one patient with liver aGVHD received IAST into the proper hepatic artery. The volume of stools and the bilirubin level improved soon after IAST. Angiography of the superior and inferior mesenteric arteries was performed in the two patients with steroid-refractory gut aGVHD, and identical abnormal findings were obtained. IAST might be an earlier option for steroid-refractory aGVHD.
Nakai
K
K
First Department of Internal Medicine, Kansai Medical University, Moriguchi-shi, Osaka, Japan. k-nakai@umin.ac.jp
Tajima
K
K
Tanigawa
N
N
Matsumoto
N
N
Zen
K
K
Nomura
S
S
Fujimoto
M
M
Kishimoto
Y
Y
Amakawa
R
R
Sawada
S
S
Fukuhara
S
S
D000208:Acute Disease; D000328:Adult; D000792:Angiography; D004351:Drug Resistance; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007269:Injections, Intra-Arterial; D007410:Intestinal Diseases / Q000188:drug therapy; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013256:Steroids / Q000008:administration & dosage*
D013256:Steroids