title: Virological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfection.
abstract: An HIV-1 infected man who experienced rapid disease progression and poor response to therapy after starting a new sexual relationship with an infected partner is known as the 'Ottawa superinfection case'. Subsequent analysis of viral sequences of protease, reverse transcriptase, Gag p17, and Env V3 provided no evidence for the acquisition of genetically divergent viruses before disease progression or drug resistance during virological failure of combination therapy. Whether HIV-1 superinfection contributes to disease progression or the spread of drug-resistant HIV-1 remains unknown.
authors.affiliation: Ottawa Health Research Institute and the Ottawa Hospital, University of Ottawa, Ottawa, Canada.
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Angel
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hu
authors.forename: Stephen
authors.initials: S
authors.lastname: Kravcik
authors.forename: Rose
authors.initials: R
authors.lastname: Tsui
authors.forename: Kok H
authors.initials: KH
authors.lastname: Lee
authors.forename: Jason
authors.initials: J
authors.lastname: Barbour
authors.forename: Evan
authors.initials: E
authors.lastname: Balaskas
authors.forename: Bernard M
authors.initials: BM
authors.lastname: Branson
authors.forename: Eric L
authors.initials: EL
authors.lastname: Delwart
authors.forename: Robert M
authors.initials: RM
authors.lastname: Grant
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018450:Disease Progression; D024882:Drug Resistance, Viral / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D017421:Sequence Analysis; D012747:Sexual Partners; D015163:Superinfection / Q000821:virology*; D019562:Viral Load