title: Tissue factor and tissue factor pathway inhibitor.
abstract: The classical 'cascade/waterfall' hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways. Recent molecular biology and clinical data indicate that tissue factor/factor-VII interaction is the primary cellular initiator of coagulation in vivo. The process of blood coagulation is divided into an initiation phase followed by a propagation phase. The discovery of tissue factor pathway inhibitor further supports the revised theory of coagulation. Tissue factor is also a signalling receptor. Recent evidence has shown that blood-borne tissue factor has an important procoagulant function in sepsis, atherosclerosis and cancer, and other functions beyond haemostasis such as immune function and metastases.
authors.affiliation: Intensive Care Unit, University of New South Wales at St George Hospital, Kogarah, NSW 2217, Australia.
authors.forename: G C
authors.initials: GC
authors.lastname: Price
authors.forename: S A
authors.initials: SA
authors.lastname: Thompson
authors.forename: P C A
authors.initials: PC
authors.lastname: Kam
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D006801:Humans; D008074:Lipoproteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013925:Thromboplastin / Q000502:physiology*; D013927:Thrombosis / Q000503:physiopathology
chemical_list: D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin