Diagnostic markers of infection in neonates.
Diagnostic markers of infection are useful indicators of neonatal sepsis. Serial measurements of infection markers can improve diagnostic sensitivity, and the use of multiple markers can enhance diagnostic accuracy. Current evidence suggests that promising markers may be useful for early termination of antimicrobial treatment, but none of the current diagnostic tests are sensitive and specific enough to influence the clinical decision for withholding antibiotic treatment at the onset of suspected infection.
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Department of Paediatrics, Prince of Wales Hospital, Hong Kong. palcheungng@cuhk.edu.hk
D000209:Acute-Phase Proteins / Q000032:analysis; D000942:Antigens, Bacterial / Q000097:blood; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D001772:Blood Cell Count; D015815:Cell Adhesion Molecules / Q000097:blood; D016207:Cytokines / Q000097:blood; D005434:Flow Cytometry; D006801:Humans; D007231:Infant, Newborn; D011379:Prognosis
D000209:Acute-Phase Proteins; D000942:Antigens, Bacterial; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines