Quaternary isoquinoline alkaloids from Xylopia parviflora.
From the quaternary alkaloidal fraction of the bark and the root of Xylopia parviflora (Annonaceae), four isoquinoline alkaloids, xylopinidine, dehydrocoreximine, N, N-dimethylanomurine and N-methylphoebine were isolated along with the known compounds, pycnarrhine, lotusine, 6,7-dimethoxy-2-methyl-isoquinolinium salt, 1,2-dehydroreticuline, (-)-phellodendrine, (+)-tembetarine, (-)-litcubine, (+)-magnoflorine, tetradehydroreticuline, (-)-oblongine, (+)-menisperine, (+)-N-methylcorydine, stepharanine, (+)-xanthoplanine, dehydrodiscretine, jatrorrhizine and palmatine. 3,4-Dihydro-6,7-dimethoxy-2-methyl-isoquinolinium and N-methylpurpuerine were isolated as natural products for the first time. Their structures were determined on the basis of spectroscopic evidence.
Nishiyama
Yumi
Y
Natural Medicinal Chemistry, Kobe Pharmaceutical University, Higashinada-ku, Kobe 658-8558, Japan. nisiyama@kobepharma-u.ac.jp
Moriyasu
Masataka
M
Ichimaru
Momoyo
M
Iwasa
Kinuko
K
Kato
Atsushi
A
Mathenge
Simon G
SG
Chalo Mutiso
Patrick B
PB
Juma
Francis D
FD
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D029061:Annonaceae / Q000737:chemistry*; D007546:Isoquinolines / Q000737:chemistry* / Q000302:isolation & purification; D013058:Mass Spectrometry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D007546:Isoquinolines