Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops).
A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fluid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.
Maina
Naomi
N
Primate Division, Kenya Trypanosomiasis Research Institute, Kikuyu, Kenya. Department of Zoology, University of Aberdeen, Aberdeen AB29 2TZ, Scotland, United Kingdom.
Ngotho
Joseph Maina
JM
Were
Tom
T
Thuita
John Kibuthu
JK
Mwangangi
David Mumo
DM
Kagira
John Maina
JM
Ndung'u
Joseph Mathu
JM
Sternberg
Jeremy
J
D000818:Animals; D015703:Antigens, CD / Q000097:blood / Q000134:cerebrospinal fluid; D002522:Chlorocebus aethiops; D016207:Cytokines / Q000097:blood* / Q000134:cerebrospinal fluid*; D004195:Disease Models, Animal; D018836:Inflammation Mediators / Q000097:blood* / Q000134:cerebrospinal fluid*; D007371:Interferon-gamma / Q000097:blood / Q000134:cerebrospinal fluid; D018512:Parasitemia / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I; D013997:Time Factors; D016833:Trypanosoma brucei rhodesiense; D014353:Trypanosomiasis, African / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000378:metabolism
D015703:Antigens, CD; D016207:Cytokines; D018836:Inflammation Mediators; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma