Fate of 130 hemagglutinins from different influenza A viruses.
In this study, we use our probabilistic models to analyze 130 hemagglutinins from different influenza A virus in order to gain the insight into their fate. The results provide three lines of evidence regarding the H5, H6, and H9 hemagglutinins: (i) the H5 hemagglutinins are more sensitive to mutations, this is the current state of the H5, H6, and H9 hemagglutinins; (ii) the H5 hemagglutinins had experienced more mutations in the past, this is the history of the H5, H6, and H9 hemagglutinins; and (iii) the H6 hemagglutinins has a bigger potential towards future mutations, this is the future of the H5, H6, and H9 hemagglutinins. Furthermore, this study gives two clues on the mutation tendency that is a degeneration process and the species susceptibility that is the chickens and ducks.
Wu
Guang
G
DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province, CN-518054, China. hongguanglishibahao@yahoo.com
Yan
Shaomin
S
D006388:Hemagglutinins / Q000737:chemistry* / Q000145:classification; D009980:Influenza A virus / Q000737:chemistry* / Q000145:classification; D011336:Probability
D006388:Hemagglutinins