title: Intraarterial thrombolysis trials in acute ischemic stroke.
abstract: Stroke is a common cause of death and disability in industrialized nations. Technical advances and the increased availability of noninvasive brain imaging techniques have permitted precise and early diagnosis of acute cerebral ischemia. This has made emergent thrombolytic therapy for rapid restoration of cerebral perfusion increasingly possible. Herein, the authors present a review of the clinical trials investigating acute stroke treatment with intraarterial thrombolysis.
authors.affiliation: Division of Interventional Neuroradiology, Room L352, University of California at San Francisco Medical Center, 505 Parnassus Avenue, San Francisco, California 94143-0628, USA.
authors.forename: Perry P
authors.initials: PP
authors.lastname: Ng
authors.forename: Randall T
authors.initials: RT
authors.lastname: Higashida
authors.forename: Sean P
authors.initials: SP
authors.lastname: Cullen
authors.forename: Reza
authors.initials: R
authors.lastname: Malek
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Dowd
authors.forename: Van V
authors.initials: VV
authors.lastname: Halbach
mesh_terms: D000208:Acute Disease; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy*; D015912:Thrombolytic Therapy; D014057:Tomography, X-Ray Computed; D014481:United States / Q000453:epidemiology
chemical_list: D005343:Fibrinolytic Agents