Long-term exercise down-regulates leptin receptor mRNA in the arcuate nucleus.
The purpose of this study was to investigate the effects of exercise on blood leptin concentrations and expression of leptin receptor subtype-b (Ob-Rb) mRNA in the arcuate nucleus of hypothalamus (ARC). Male Wistar rats (26 weeks old) underwent regular wheel exercise for 12 weeks. The expression of Ob-Rb mRNA in the ARC decreased at the end of the study period despite reductions of abdominal fat-pad weight and serum leptin concentration. Serum 1,5-anhydroglucitol levels were higher in exercising rats, suggesting lower serum insulin levels in exercising rats. Our results suggested that 12-week wheel exercise reduced the expression of Ob-Rb mRNA in the ARC probably through improvement in insulin resistance.
Kimura
Masaki
M
Department of Pharmacotherapeutics, Kyoritsu College of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan. mkimura@jikei.ac.jp
Tateishi
Naoto
N
Shiota
Tomoei
T
Yoshie
Fumihiko
F
Yamauchi
Hideki
H
Suzuki
Masato
M
Shibasaki
Toshiaki
T
D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism; D015536:Down-Regulation / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood*; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface / Q000235:genetics*; D054411:Receptors, Leptin; D013995:Time
D020738:Leptin; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose; D005947:Glucose