TRAIL is expressed in the brain cells of Alzheimer's disease patients.
Tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) is a novel cytokine characterized by selective killing activity against tumour cells. We recently found that beta-amyloid-induced apoptosis in a human neuronal cell line was mediated via induction of TRAIL. Here, we show that TRAIL is specifically expressed in the brain of Alzheimer's disease (AD) patients and completely absent in the brain of non-demented patients. TRAIL-like immunoreactivity was localized in AD affected regions, such as cerebral cortex, often in the proximity of Congo-red-positive amyloid plaques. These findings suggest that neurons represent an independent and potential source of TRAIL, suggesting that the latter acts redundantly with other noxious stimuli in neurodegenerative diseases characterized by amyloidosis and neuroinflammation.
Uberti
Daniela
D
Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Viale Europa 11, 25123 Brescia, Italy. uberti@med.unibs.it
Cantarella
Giuseppina
G
Facchetti
Fabio
F
Cafici
Alessia
A
Grasso
Giuseppe
G
Bernardini
Renato
R
Memo
Maurizio
M
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D001921:Brain / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009410:Nerve Degeneration / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D058225:Plaque, Amyloid / Q000378:metabolism; D012680:Sensitivity and Specificity; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha