title: Personality disorder and social anxiety predict delayed response in drug and behavioral treatment of panic disorder.
abstract: BACKGROUND
  The aim of this study was to analyze the impact of pretreatment characteristics and personality disorders on the onset of response in the treatment of panic disorder.
  
  
  METHODS
  The data of 73 out-patients with panic disorder who had completed at least 6 weeks of a randomized trial of 24 weeks of either paroxetine only or paroxetine combined with cognitive group-therapy were analyzed in a Cox proportional hazards model.
  
  
  RESULTS
  The likelihood of having responded to treatment (defined by a CGI rating of improvement) was more than twice as high for patients without a personality disorder or social phobia than for Patients with a personality disorder or social phobia.
  
  
  CONCLUSIONS
  We suggest that patients with these characteristics do benefit from prolonged treatment, and they may profit from an additional treatment focused on social anxiety.
authors.affiliation: Department of Psychiatry, Division of Social Psychiatry, University of Vienna, Austria. peter.berger@akh-wien.ac.at
authors.forename: Peter
authors.initials: P
authors.lastname: Berger
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sachs
authors.forename: Michaela
authors.initials: M
authors.lastname: Amering
authors.forename: Anita
authors.initials: A
authors.lastname: Holzinger
authors.forename: Bettina
authors.initials: B
authors.lastname: Bankier
authors.forename: Heinz
authors.initials: H
authors.lastname: Katschnig
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D017374:Paroxetine / Q000627:therapeutic use*; D010554:Personality Disorders / Q000453:epidemiology*; D010698:Phobic Disorders / Q000453:epidemiology*; D011379:Prognosis; D016016:Proportional Hazards Models; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors