Prophylaxis of iodinated contrast media-induced nephropathy: a pharmacological point of view.
Iodinated contrast media are a frequent cause of acute renal failure, especially in patients whose renal function is already impaired. In addition to hydration, which remains the most commonly acknowledged means of protection, numerous pharmacological approaches for the prophylaxis of contrast nephropathy have been tested so far. They include diuretics, calcium channel blockers, adenosine receptor antagonists, N-acetylcysteine, low-dose dopamine and the dopamine D1 receptor agonist fenoldopam, endothelin receptor antagonists, and even captopril. The present review of the literature critically discusses the drugs used to prevent contrast nephropathy from a pharmacological point of view.
Idé
Jean-Marc
JM
Research Division, Guerbet, Aulnay-sous-Bois, France. ideej@guerbet-group.com
Lancelot
Eric
E
Pines
Emmanuelle
E
Corot
Claire
C
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D003287:Contrast Media / Q000009:adverse effects*; D004232:Diuretics / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000627:therapeutic use; D065128:Endothelin Receptor Antagonists; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D017613:Iodine Compounds / Q000009:adverse effects*; D058915:Purinergic P1 Receptor Antagonists
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D002316:Cardiotonic Agents; D003287:Contrast Media; D004232:Diuretics; D018491:Dopamine Agonists; D065128:Endothelin Receptor Antagonists; D016166:Free Radical Scavengers; D017613:Iodine Compounds; D058915:Purinergic P1 Receptor Antagonists