Synthesis and cytotoxic activity of novel quinazolino-beta-carboline-5-one derivatives.
A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 microM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts.
Baruah
Bipul
B
Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500050, India.
Dasu
Kavitha
K
Vaitilingam
Balasubramanian
B
Mamnoor
Premkumar
P
Venkata
Prasanthi Penubaka
PP
Rajagopal
Sriram
S
Yeleswarapu
Koteswar Rao
KR
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011799:Quinazolines / Q000737:chemistry*
D000970:Antineoplastic Agents; D002243:Carbolines; D011799:Quinazolines