title: Changes in antioxidant enzyme activity and malondialdehyde level in patients with age-related macular degeneration.
abstract: Age-related macular degeneration is the leading cause of legal blindness in the developed world, and yet its pathogenesis remains poorly understood. Oxidative stress may play a major role in the etiology and pathogenesis of age-related disorders such as age-related macular degeneration. Catalase is an antioxidant enzyme which plays an important role in the detoxification of free oxygen radicals. Malondialdehyde is a marker that shows free radical damage. We have measured the erythrocyte activity of catalase and the serum level of malondialdehyde in 30 patients with age-related macular degeneration and 60 healthy subjects. Patients with age-related macular degeneration showed significantly lower catalase activity compared to healthy subjects (p = 0.002). Plasma malondialdehyde level of the patient group was significantly higher than that of the controls (p = 0.038).
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Mersin University, Mersin, Turkey. dryildrimoz@hotmail.com
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yildirim
authors.forename: Nurcan Aras
authors.initials: NA
authors.lastname: Ateş
authors.forename: Lülüfer
authors.initials: L
authors.lastname: Tamer
authors.forename: Necati
authors.initials: N
authors.lastname: Muşlu
authors.forename: Bahadir
authors.initials: B
authors.lastname: Ercan
authors.forename: Uğur
authors.initials: U
authors.lastname: Atik
authors.forename: Arzu
authors.initials: A
authors.lastname: Kanik
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D012727:Sex Characteristics
chemical_list: D008315:Malondialdehyde; D002374:Catalase