title: The structure of GRK2-G beta gamma complex: intimate association of G-protein signaling modules.
abstract: G-protein-mediated signaling is the most widely used signaling mechanism in cells and its regulation is crucial for various physiological functions. G-protein-coupled receptor (GPCR) kinases (GRKs) are involved in the desensitization of GPCR signals. Recently, the X-ray crystal structure of GRK2 complexed with G beta gamma was demonstrated and revealed the intimate association of three important signaling modules with G beta gamma to regulate GRK2 activity.
authors.affiliation: Department of Pharmacology, University of Illinois at Chicago, 60612, USA. tkozas@uic.edu
authors.forename: Tohru
authors.initials: T
authors.lastname: Kozasa
mesh_terms: D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology*; D020555:GTP-Binding Protein Regulators / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013329:Structure-Activity Relationship; D051552:beta-Adrenergic Receptor Kinases
chemical_list: D020555:GTP-Binding Protein Regulators; D017868:Cyclic AMP-Dependent Protein Kinases; D051552:beta-Adrenergic Receptor Kinases