title: [Metabolism of proinflammatory cytokine (interleukin-1 beta) and oxidant activity of neutrophils in various forms of chronic bronchitis].
abstract: OBJECTIVE
  To study content of interleukin-1 beta (IL-1 beta) and free radical oxidation in neutrophils of blood, saliva and bronchoalveolar lavage (BAL) in chronic bronchitis for prediction of obstructive defects.
  
  
  METHODS
  Enzyme immunoassay was used to measure IL-1 beta in the blood, saliva, BAL of 49 males with chronic bronchitis aged 39-72 years. Functional ability of the neutrophils to generate free oxygen radicals was assessed by luminol-dependent chemiluminescence.
  
  
  RESULTS
  Patients with chronic obstructive bronchitis exhibited excessive accumulation of IL-1 beta in the blood and BAL, enhanced activity of hematosalivary barrier for IL-1 beta and production of active oxygen radicals by systemic and tissue neutrophils.
  
  
  CONCLUSIONS
  Elevated concentration of systemic and tissue IL-1 beta, activation of free radical oxidation by blood neutrophils and BAL, enhancement of hematosalivary barrier for IL-1 beta can be considered as prognostically unfavourable factors of bronchial obstruction in patients with chronic bronchitis.
authors.forename: L B
authors.initials: LB
authors.lastname: Postnikova
authors.forename: O P
authors.initials: OP
authors.lastname: Alekseeva
authors.forename: N I
authors.initials: NI
authors.lastname: Kubysheva
authors.forename: O S
authors.initials: OS
authors.lastname: Ishanova
mesh_terms: D000328:Adult; D000368:Aged; D029481:Bronchitis, Chronic / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012463:Saliva / Q000276:immunology / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D017382:Reactive Oxygen Species