title: Maculopapular eruption with enlarged macrophages in eight patients receiving G-CSF or GM-CSF.
abstract: In the last years, granulocyte and granulocyte-macrophage colony-stimulating factors (G-CSF and GM-CSF) are being increasingly used and several cutaneous eruptions have been reported in relation to these treatments. In 1991 Horn et al. described three patients with maculopapular eruption that paralleled the time of infusion of GM-CSF. Two of the cases showed an increase in the number and size of macrophages in the biopsy specimen. Since then, several cases have been reported showing this histopathological alteration that has been considered characteristic of reaction to G-CSF or GM-CSF. Although maculopapular eruption with enlarged macrophages can appear after chemotherapy treatment, we have found that the presentation of this eruption after the beginning of cytokine treatment is suggestive of the involvement of G-CSF and GM-CSF in the eruption. We described eight cases of patients treated with G-CSF or GM-CSF that developed maculopapular eruptions with enlarged macrophages.
authors.affiliation: Department of Dermatology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006 Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Alvarez-Ruiz
authors.forename: P F
authors.initials: PF
authors.lastname: Peñas
authors.forename: J
authors.initials: J
authors.lastname: Fernández-Herrera
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Pérez
authors.forename: J
authors.initials: J
authors.lastname: Fraga
authors.forename: A
authors.initials: A
authors.lastname: García-Díez
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D005076:Exanthema / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013256:Steroids; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor