title: Influence of diazepam on blood glucose levels in nondiabetic and non-insulin-dependent diabetic subjects under dental treatment with local anesthesia.
abstract: The effect of diazepam on blood glucose concentration (BGC) was investigated in a double-blind cross-over study in 10 healthy and 10 non-insulin-dependent diabetic subjects taking oral hypoglycemic drugs. In the first session, fasting blood samples were taken for blood glucose and glycosylated hemoglobin estimation and at 60, 80, 95, 125, and 155 minutes thereafter for glucose estimation. In another 2 sessions, a venous sample was taken immediately before premedication (5 mg diazepam or placebo randomly given during breakfast). One hour later a blood sample was taken, and the volunteers were submitted to periodontal treatment after injection of 1.8 mL of 2% mepivacaine with 1:100,000 adrenaline. Venous blood samples were taken at 15, 30, 60, and 90 minutes after injection. The changes in BGC were analyzed using analysis of variance (ANOVA) for repeated measures; the means were compared using Tukey test (P = .05). Statistically significant differences in the BGC were observed between diabetic and nondiabetic groups (P = .00003). However, there were no significant differences among the sessions of the same group (P = .29). The results of this study show that a single dose of 5 mg diazepam before dental treatment does not influence BGC in nondiabetic and non-insulin-dependent diabetic subjects.
authors.affiliation: Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, SP, Brazil.
authors.forename: Vanessa Rocha Lima
authors.initials: VR
authors.lastname: Schaira
authors.forename: José
authors.initials: J
authors.lastname: Ranali
authors.forename: Mário José Abdalla
authors.initials: MJ
authors.lastname: Saad
authors.forename: Patrícia Cristine
authors.initials: PC
authors.lastname: de Oliveira
authors.forename: Glaúcia Maria Bovi
authors.initials: GM
authors.lastname: Ambrosano
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Volpato
mesh_terms: D000704:Analysis of Variance; D001786:Blood Glucose / Q000187:drug effects*; D018592:Cross-Over Studies; D016854:Dental Anxiety / Q000097:blood / Q000209:etiology; D017742:Dental Care for Chronically Ill; D012534:Dental Scaling / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003975:Diazepam / Q000494:pharmacology*; D004311:Double-Blind Method; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008347:Manifest Anxiety Scale; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D003975:Diazepam; D006442:Glycated Hemoglobin; D006993:Hypnotics and Sedatives