title: Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.
abstract: The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.
authors.affiliation: Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Quebec, Pointe Claire--Dorval, Canada H9R 4P8. michel_therien@merck.com
authors.forename: Michel
authors.initials: M
authors.lastname: Thérien
authors.forename: Kathryn
authors.initials: K
authors.lastname: Skorey
authors.forename: Robert
authors.initials: R
authors.lastname: Zamboni
authors.forename: Chun Sing
authors.initials: CS
authors.lastname: Li
authors.forename: Cheuk K
authors.initials: CK
authors.lastname: Lau
authors.forename: Tammy
authors.initials: T
authors.lastname: LeRiche
authors.forename: Vouy
authors.initials: V
authors.lastname: Linh Truong
authors.forename: Deena
authors.initials: D
authors.lastname: Waddleton
authors.forename: Chidambaram
authors.initials: C
authors.lastname: Ramachandran
mesh_terms: D019920:Photoaffinity Labels / Q000138:chemical synthesis* / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry*
chemical_list: D019920:Photoaffinity Labels; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases