title: Antiviral flavonoids from the seeds of Aesculus chinensis.
abstract: A bioassay-guided fractionation of an ethanol extract of the seeds of Aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10). The structures of the new compounds were elucidated by spectroscopic methods including 2D NMR. All compounds were tested for antiviral activity against respiratory syncytial virus (RSV), parainfluenza virus type 3 (PIV 3), and influenza virus type A (Flu A). Compounds 1, 2, and 6 showed significant antiviral activities against RSV with IC(50) values of 4.5, 6.7, and 4.1 microg/mL and selective index (SI) values of 15.8, 32, and 63.8, respectively. Compound 8 demonstrated significant antiviral activity against Flu A with an IC(50) of 24.5 microg/mL and a SI of 16.0, respectively.
authors.affiliation: National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing 100050, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.forename: Shuang-Cheng
authors.initials: SC
authors.lastname: Ma
authors.forename: Lin-Yun
authors.initials: LY
authors.lastname: Ma
authors.forename: Paul Pui-Hay
authors.initials: PP
authors.lastname: But
authors.forename: Rui-Chao
authors.initials: RC
authors.lastname: Lin
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D031319:Aesculus / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; C485174:aescuflavoside; C485175:aescuflavoside A