title: Novel CCR1 antagonists with improved metabolic stability.
abstract: The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.
authors.affiliation: Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. matthew_f_brown@groton.pfizer.com
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Brown
authors.forename: Mike
authors.initials: M
authors.lastname: Avery
authors.forename: William H
authors.initials: WH
authors.lastname: Brissette
authors.forename: J H
authors.initials: JH
authors.lastname: Chang
authors.forename: Kevin
authors.initials: K
authors.lastname: Colizza
authors.forename: Maryrose
authors.initials: M
authors.lastname: Conklyn
authors.forename: Amy P
authors.initials: AP
authors.lastname: DiRico
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Gladue
authors.forename: John C
authors.initials: JC
authors.lastname: Kath
authors.forename: Suzanne S
authors.initials: SS
authors.lastname: Krueger
authors.forename: Paul D
authors.initials: PD
authors.lastname: Lira
authors.forename: Brett M
authors.initials: BM
authors.lastname: Lillie
authors.forename: Greg D
authors.initials: GD
authors.lastname: Lundquist
authors.forename: Erin N
authors.initials: EN
authors.lastname: Mairs
authors.forename: Eric B
authors.initials: EB
authors.lastname: McElroy
authors.forename: Molly A
authors.initials: MA
authors.lastname: McGlynn
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Paradis
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Poss
authors.forename: Michelle I
authors.initials: MI
authors.lastname: Rossulek
authors.forename: Richard M
authors.initials: RM
authors.lastname: Shepard
authors.forename: Jeff
authors.initials: J
authors.lastname: Sims
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Strelevitz
authors.forename: Susan
authors.initials: S
authors.lastname: Truesdell
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Tylaska
authors.forename: Kwansik
authors.initials: K
authors.lastname: Yoon
authors.forename: Deye
authors.initials: D
authors.lastname: Zheng
mesh_terms: D000818:Animals; D004285:Dogs; D000882:Haplorhini; D010599:Pharmacokinetics; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*
chemical_list: D054389:Receptors, CCR1; D019707:Receptors, Chemokine