Arresting dialysis-related amyloidosis: a prospective multicenter controlled trial of direct hemoperfusion with a beta2-microglobulin adsorption column.
We investigated the clinical efficacy of direct hemoperfusion with a beta2-microglobulin (beta2-m) adsorption column for the treatment of patients with dialysis-related amyloidosis. A 2-year prospective controlled study was performed to compare the effects of passaging blood through a (beta2-m) adsorption column (Lixelle) before it is passaged through the dialysis polysulfone membrane on the severity of amyloidosis in these individuals. Patients (n = 22) whose blood went through the Lixelle column prior to dialysis had a higher beta2-m removal rate compared to an equal number of controls, and they showed earlier improvement in their symptoms which included impaired daily activities, joint stiffness, and pain. The appearance of additional bone cysts was prevented in pre-adsorbed patients but not in the controls. Thus, the Lixelle column is useful in preventing the progression of dialysis-related amyloidosis and in ameliorating or arresting the progression of the symptoms of this disorder.
Gejyo
Fumitake
F
Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. gejyo@med.niigata-u.ac.jp
Kawaguchi
Yoshindo
Y
Hara
Shigeko
S
Nakazawa
Ryoichi
R
Azuma
Nakanobu
N
Ogawa
Hiroshi
H
Koda
Yutaka
Y
Suzuki
Masashi
M
Kaneda
Hiroshi
H
Kishimoto
Hidefumi
H
Oda
Mizue
M
Ei
Kyoko
K
Miyazaki
Ryoichi
R
Maruyama
Hiroki
H
Arakawa
Masaaki
M
Hara
Mitsuru
M
D000203:Activities of Daily Living; D000686:Amyloidosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001175:Arthrography; D001845:Bone Cysts / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D007596:Joints / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D001613:beta 2-Microglobulin / Q000097:blood*
D001613:beta 2-Microglobulin