No correlation between moving phosphene and motor thresholds: a transcranial magnetic stimulation study.
The aim of this study was to investigate the temporal stability of moving phosphenes and to assess whether moving phosphene thresholds (PTs) correlate with motor thresholds (MTs). Small moving sensations, so-called moving phosphenes, are perceived when V5, an area important for visual motion analysis, is stimulated by transcranial magnetic stimulation (TMS). However, it is still a matter of debate if V5 phosphenes are stable sensations across measurements and if they are a reasonable index of the cortical excitability of V5. Currently, MT is more commonly used as an index of global cortical excitability. However, previous studies have indicated that stationary PTs are suitable alternatives when the primary visual cortex is stimulated by TMS. Using paired-pulse TMS, stationary and moving PTs and applying single pulse TMS, MTs were measured in 11 subjects. PTs were retested in nine subjects 5-7 days later. Stationary and moving PTs were stable within subjects across the two sessions and showed a high inter-correlation. Conversely, PTs and MTs did not correlate. Our results are in agreement with previous studies showing that excitatory measurements of one specific cortex cannot be generalized to the excitability of the whole cortex. Thus, we propose specific measures for cortices of interest: PT for visual experiments and MT for motor experiments.
Antal
Andrea
A
Department of Clinical Neurophysiology, George-August University of Göttingen, Robert Koch Strasse 40, 37075 Göttingen, Germany. Aantal@gwdg.de
Nitsche
Michael A
MA
Kincses
Tamás Z
TZ
Lampe
Christian
C
Paulus
Walter
W
D000328:Adult; D004558:Electric Stimulation; D004574:Electromagnetic Fields; D019054:Evoked Potentials, Motor / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D010719:Phosphenes / Q000502:physiology*; D010775:Photic Stimulation; D012684:Sensory Thresholds / Q000502:physiology*; D013223:Statistics as Topic; D050781:Transcranial Magnetic Stimulation; D014793:Visual Cortex / Q000502:physiology*