title: [Five years of proton therapy of eye neoplasms at the Hahn-Meitner Institute, Berlin].
abstract: Eye tumors (choroidal melanomas, iris melanomas, and choroidal hemangiomas) are being treated with 68 MeV protons since 1998 at the Ion Beam Laboratory of the Hahn-Meitner Institute of Berlin (Germany's first proton therapy center), in cooperation with the Charité University Hospital in Berlin, Campus Benjamin Franklin. The proton beam, generated via a combination of Van de Graaff accelerator and cyclotron, is prepared by passive shaping for conformal tumor irradiation. A digital X-ray verification of the tumor location with the patient in sitting position limits the position uncertainties to a maximum of 0.3 mm. The treatment planning is performed using the program EYEPLAN. OCTOPUS, a CT-based planning program developed in cooperation with the German Cancer Research Center of Heidelberg, is under pre-clinical testing. Thus far, more than 400 patients have been irradiated. The first results are comparable to those obtained in other proton therapy centers. At the end of 2002, the University Hospital of Essen has also become a cooperation partner of the Hahn-Meitner Institute.
authors.affiliation: Hahn-Meitner-Institut Berlin, Augentumortherapie. heufelder@hmi.de
authors.forename: Jens
authors.initials: J
authors.lastname: Heufelder
authors.forename: Dino
authors.initials: D
authors.lastname: Cordini
authors.forename: Hermann
authors.initials: H
authors.lastname: Fuchs
authors.forename: Jürgen
authors.initials: J
authors.lastname: Heese
authors.forename: Heinrich
authors.initials: H
authors.lastname: Homeyer
authors.forename: Heinz
authors.initials: H
authors.lastname: Kluge
authors.forename: Hans
authors.initials: H
authors.lastname: Morgenstern
authors.forename: Stefan
authors.initials: S
authors.lastname: Höcht
authors.forename: Martin
authors.initials: M
authors.lastname: Nausner
authors.forename: Nikolaos E
authors.initials: NE
authors.lastname: Bechrakis
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hinkelbein
authors.forename: Michael H
authors.initials: MH
authors.lastname: Foerster
mesh_terms: D000047:Academies and Institutes; D001604:Berlin; D002830:Choroid Neoplasms / Q000532:radiotherapy; D017357:Cyclotrons; D005134:Eye Neoplasms / Q000532:radiotherapy*; D006391:Hemangioma / Q000532:radiotherapy; D006785:Hospitals, University; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008545:Melanoma / Q000532:radiotherapy; D010315:Particle Accelerators; D019047:Phantoms, Imaging; D061766:Proton Therapy; D011880:Radiotherapy Planning, Computer-Assisted; D014057:Tomography, X-Ray Computed; D011522:Protons
chemical_list: D011522:Protons