Synthesis, biodistribution and quantitative structure-activity relationship studies of new 99mTc labeled pseudo-peptide complexes.
Twelve new peptide or pseudo-peptide chelators have been synthesized in the course of our continuing investigation of 99mTc-labelled peptides for application for renal imaging agents. All compounds were characterized on the basis of, IR, 1HNMR, 13CNMR spectroscopy, as well as MS and elemental analysis. All peptides yield stable 99mTc complexes using Sn(II) reactive coupling and exhibit renal uptake. Linear regression analysis between Logarithm of renal uptake value (RU) and the parameters obtained by the ZINDO/1 method was performed. Some equations were obtained which showed that molecular polar and charge have some relationship with their renal uptake.
Zhang
Huabei
H
Department of Chemistry, Beijing Normal University, Beijing 100875, China.
Dai
Mei
M
Qi
Chuanmin
C
Li
Bo
B
Guo
Xuefeng
X
D000818:Animals; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D005260:Female; D007668:Kidney / Q000378:metabolism; D016014:Linear Models; D051379:Mice; D008815:Mice, Inbred Strains; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D021281:Quantitative Structure-Activity Relationship; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution
D002614:Chelating Agents; D015609:Organotechnetium Compounds; D010455:Peptides; D019275:Radiopharmaceuticals