title: Rosai-Dorfman disease manifesting as multiple subcutaneous nodules. Report of a case with diagnosis on a fine needle aspirate.
abstract: BACKGROUND
  Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, is a benign, self-limiting histiocytic proliferative disorder commonly involving the lymph nodes. Extranodal disease occurs in about 40% of cases, and the sites involved are skin, nasal cavity, paranasal sinuses, eyelids, orbit, bone and central nervous system.
  
  
  METHODS
  A case of RDD presented as subcutaneous nodules and was diagnosed on a fine needle aspirate. The aspirate revealed numerous histiocytes with phagocytosis of lymphocytes, plasma cells and neutrophils. Surgical biopsy and immunocytochemical stain for S-100 protein confirmed the diagnosis. Later the patient developed lymphadenopathy and involvement of the nasal septum.
  
  
  CONCLUSIONS
  Extranodal RDD can be diagnosed by FNAC in conjunction with immunocytochemistry.
authors.affiliation: Cytopathology Laboratory, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
authors.forename: N Gopendro
authors.initials: NG
authors.lastname: Singh
authors.forename: Kusum
authors.initials: K
authors.lastname: Kapila
authors.forename: Sandeep
authors.initials: S
authors.lastname: Mathur
authors.forename: Ruma
authors.initials: R
authors.lastname: Ray
authors.forename: Kusum
authors.initials: K
authors.lastname: Verma
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D044963:Biopsy, Fine-Needle; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D007962:Leukocytes / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology; D009300:Nasal Septum / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D040521:Subcutaneous Tissue / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D009418:S100 Proteins