title: Systemic cytomegalovirus infection complicating ulcerative colitis: a case report and review of the literature.
abstract: Cytomegalovirus is a common infection worldwide and in the immunocompromised individual it can be a major cause of morbidity and mortality. In patients with inflammatory bowel disease cytomegalovirus infection has been described in both immunocompetent and immunocompromised individuals. A 34 year old man with an exacerbation of his colitis was diagnosed as having both cytomegalovirus colitis and hepatitis. The diagnosis was made on the classical appearance of "owl's eye" inclusion bodies on colonic and hepatic biopsies and, in addition, viral serology and polymerase chain reaction (PCR) analysis of the cytomegalovirus DNA copy number. Fourteen days of treatment with ganciclovir led to a prompt improvement in the symptoms of colitis, resolution of the pyrexia, normalisation of the liver function tests, and clearance of the virus, as measured by a negative cytomegalovirus DNA PCR. Cytomegalovirus infection is a potentially fatal complication of treatment induced immunosuppression in patients with inflammatory bowel disease. As in this case, infection may be systemic and not confined to the intestine. Prompt diagnosis using histology, serology, and PCR analysis allows prompt introduction of therapy and an improved prognosis.
authors.affiliation: Department of Medicine, St James's University Hospital, Leeds, West Yorkshire, UK. pj.hamlin@ukgateway.net
authors.forename: P J
authors.initials: PJ
authors.lastname: Hamlin
authors.forename: M N
authors.initials: MN
authors.lastname: Shah
authors.forename: N
authors.initials: N
authors.lastname: Scott
authors.forename: J I
authors.initials: JI
authors.lastname: Wyatt
authors.forename: P D
authors.initials: PD
authors.lastname: Howdle
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects; D003093:Colitis, Ulcerative / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006505:Hepatitis; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D001379:Azathioprine; D015774:Ganciclovir