title: Tailored therapy of adult acute leukaemia in Jehovah's Witnesses: unjustified reluctance to treat.
abstract: Treatment of acute leukaemia in adult Jehovah's Witnesses (JW) is challenging because of 'a priori' refusal of most physicians to apply diagnostic and therapeutic procedures to haematological abnormalities resembling acute leukaemia. Rejection of blood transfusions by individuals of this faith is usually blamed to justify this attitude, thus leading to severe personal, medical and psychological distress related to the lack of care. We therefore intended to verify whether a standard (tailored) chemotherapy, without the use of prophylactic blood product transfusions, could be applied during treatment of acute leukaemia under such circumstances. Eleven consecutive JW adult patients with acute leukaemia, all of whom had been denied care in other institutions, were treated at the European Institute of Oncology (EIO) in Milan, Italy. Five had acute lymphoblastic leukaemia (ALL) (one bcr/abl positive), six had acute myeloid leukaemia (AML) with immunophenotype and/or cytogenetic intermediate-high risk features, except one patient with acute promyelocytic leukaemia (APML). Standard induction chemotherapy [cytosine arabinoside (ARA-C) and daunorubicin (DNR) for AML, vincristine (VCR), DNR and prednisone (PDN) for ALL, all-trans retinoic acid (ATRA) and DNR for APML] with the antracycline dose of at least 30 mg/sqm were used. All patients experienced severe anaemia after induction chemotherapy despite erythropoietin. Median haemoglobin nadir for patients with ALL and AML was 4.5 g/dL (range 1.3-6.9) and 5.1 g/dL (range 2.6-6.8), respectively. Median platelet nadir counts for all patients was 14.5 x 10(9))/L (range 1-24). One patient died during induction probably due to haemorrhage. Four of five patients with ALL achieved a complete remission (CR) (including the bcr/abl case) while among patients with AML only the one with APML achieved CR. Three patients (APML = 1 and ALL = 2) are still alive and disease-free. This small series of adult patients with leukaemia illustrates difficulties in treating patients who are practising JW, yet nevertheless provides a significant argument against the prejudicial decision leading to evasion of treatment in these patients.
authors.affiliation: Division of Hematology-Oncology, Department of Medicine, European Institute of Oncology, Milan, Italy. daniele.laszlo@ieo.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Laszlo
authors.forename: Alberto
authors.initials: A
authors.lastname: Agazzi
authors.forename: Aron
authors.initials: A
authors.lastname: Goldhirsch
authors.forename: Saverio
authors.initials: S
authors.lastname: Cinieri
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
authors.forename: Cristina
authors.initials: C
authors.lastname: Rabascio
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Pruneri
authors.forename: Liliana
authors.initials: L
authors.lastname: Calabrese
authors.forename: Angela
authors.initials: A
authors.lastname: Cocquio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
mesh_terms: D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D019090:Case Management; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D033221:Jehovah's Witnesses; D007938:Leukemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D010342:Patient Acceptance of Health Care; D016079:Refusal to Treat; D012074:Remission Induction; D014212:Tretinoin / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D006454:Hemoglobins; D003561:Cytarabine; D014212:Tretinoin; D014750:Vincristine; D005047:Etoposide; D003630:Daunorubicin