Expression of beta-catenin in developing auditory epithelia of mice.
This study investigated the role of beta-catenin in the development of mouse auditory epithelia. Inner ears obtained from embryonic and newborn mice were used. Expression of beta-catenin was examined together with the expression of Ki-67, a marker for proliferating cells, or myosin VIIa, a marker for differentiated hair cells. In the early phase of development, intense expression of beta-catenin was found in auditory epithelia in which a number of Ki-67-positive cells were identified. Together with a decrease in proliferating cells, the intensity and area of beta-catenin expression were reduced. In addition, during differentiation and maturation of hair cells, the area of beta-catenin expression was further limited. These findings suggest that patterns of expression of beta-catenin are closely linked with the status of auditory epithelia development.
Takebayashi
Shinji
S
Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakagawa
Takayuki
T
Kojima
Ken
K
Kim
Tae-Soo
TS
Kita
Tomoko
T
Dong
Youyi
Y
Endo
Tsuyoshi
T
Iguchi
Fukuichiro
F
Naito
Yasushi
Y
Omori
Koichi
K
Ito
Juichi
J
D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D003051:Cochlea / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism* / Q000502:physiology; D004398:Dyneins; D005314:Embryonic and Fetal Development; D004848:Epithelium / Q000196:embryology / Q000254:growth & development / Q000378:metabolism; D005260:Female; D006198:Hair Cells, Auditory / Q000254:growth & development; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D000081412:Myosin VIIa; D009218:Myosins / Q000378:metabolism; D011247:Pregnancy; D015534:Trans-Activators / Q000378:metabolism* / Q000502:physiology; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D019394:Ki-67 Antigen; C000631456:Myo7a protein, mouse; D000081412:Myosin VIIa; D015534:Trans-Activators; D051176:beta Catenin; D009218:Myosins; D004398:Dyneins