title: Lower incidence rates but thicker melanomas in Eastern Europe before 1992: a comparison with Western Europe.
abstract: The objective of this study was to investigate the epidemiology of melanoma across Europe with regard to Breslow thickness and body-site distribution. Incidence data from Cancer Incidence in 5 Continents and the EUROCARE-melanoma database were used: 28?117 melanoma cases from 20 cancer registries in 12 European countries, diagnosed between 1978 and 1992. Regression analysis and general linear modelling were used to analyse the data. Melanomas in Eastern Europe were on average 1.4 mm thicker (P<0.05) than in Western Europe and appeared more often on the trunk. From 1978 to 1992, their Breslow thickness had decreased in Western but not Eastern Europe. There was a latitude gradient in incidence, with highest rates in southern regions in Eastern Europe and an inverse gradient in Western Europe, with highest rates in the North. Mortality:incidence ratios were less favourable in southern parts across Europe, especially in Eastern Europe. If Eastern European populations copy the sunbathing behaviour of the West it is likely that in the near future a higher melanoma incidence can be expected there.
authors.affiliation: Department of Public Health, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GD Rotterdam, The Netherlands. e.devries@erasmusmc.nl
authors.forename: E
authors.initials: E
authors.lastname: de Vries
authors.forename: M
authors.initials: M
authors.lastname: Boniol
authors.forename: J F
authors.initials: JF
authors.lastname: Doré
authors.forename: J W W
authors.initials: JW
authors.lastname: Coebergh
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005060:Europe / Q000453:epidemiology; D005061:Europe, Eastern / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008545:Melanoma / Q000401:mortality* / Q000473:pathology; D008875:Middle Aged; D012044:Regression Analysis; D017678:Sex Distribution; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology*