title: Prevalence of autoantibody in cerebrospinal fluids from dogs with various CNS diseases.
abstract: To examine the prevalence of autoantibody in canine cerebrospinal fluids (CSFs), CSFs were collected from 14 healthy controls and 88 clinical cases with various diseases in the central nervous system (CNS), and were analyzed by an indirect fluorescence antibody test on frozen sections of the cerebrum from normal Beagle dogs. An anti-astrocyte autoantibody was detected in 31 clinical cases with titers ranging from 1:1 to >/=1:100. All tested cases with necrotizing meningoencephalitis (NME: n=22) and granulomatous meningoencephalitis (GME: n=3) possessed the anti-astrocyte autoantibody, while the autoantibody was negative in most cases with other inflammatory CNS diseases. The autoantibody was also detected in 4 of 12 cases with brain tumors. Hence, examination of the autoantibody in the canine CFS would be significant for diagnosing NME and/or GME, as well as for understanding peritumoral events in cases with brain tumors.
authors.affiliation: Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Matsuki
authors.forename: Kaori
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tamahara
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Satoru
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Kunio
authors.initials: K
authors.lastname: Doi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ogawa
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ono
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000134:cerebrospinal fluid* / Q000276:immunology*; D004285:Dogs; D019084:Fluorescent Antibody Technique, Indirect; D013687:Telencephalon / Q000276:immunology
chemical_list: D001323:Autoantibodies