GALOP syndrome: case report with 7-year follow-up.
An elderly woman complaining of a gait disorder was found to have the GALOP syndrome (gait ataxia, late-onset polyneuropathy). She exhibited mild distal weakness and sensory loss in the legs, a positive Romberg, and an unsteady gait. Serum immunofixation disclosed a monoclonal IgM-kappa protein. There was specific IgM binding to galopin, a central nervous system white matter antigen. Periodic treatment with intravenous immunoglobulin has alleviated her neurologic symptoms. She has now been followed for 7 years and maintained significant improvement in neurologic symptoms and signs.
Alpert
Jack N
JN
Department of Neurology, Saint Luke's Episcopal Hospital, Houston, TX 77030, USA.
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D020234:Gait Ataxia / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D011115:Polyneuropathies / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy*; D013577:Syndrome