title: [Diltiazem and verapamil therapy in patients with angina pectoris associated with arterial hypotension].
abstract: A randomized blind cross-over study with placebo lead-in compared efficacy of calcium antagonists diltiazem and verapamil in 71 patients with stable angina concurrent with arterial hypotension (group 1) and 38 normotensive patients with ischemic heart disease (group 2). By acute bicycle exercise test evidence, verapamil was effective in 80% and 82% patients of group 1 and 2, respectively, dilitiazem--in 67 and 77%, respectively. Cumulation of the effect (p < 0.01) to the third month of verapamil course was comparable in both groups. Tolerance to an antianginal effect of dilitazem developed in 53% patients of group 1 (against 30% in group 2, p < 001) in 2-4 weeks of therapy (against 4-12 weeks in group 2, p < 0.05). By stress 199-T1 scintigraphy of the myocardium, administration of effective doses of diltiazem reduced the number of hypoperfused segments by at least 30%.
authors.forename: E M
authors.initials: EM
authors.lastname: Idrisova
authors.forename: T A
authors.initials: TA
authors.lastname: Stepacheva
authors.forename: N V
authors.initials: NV
authors.lastname: Borovkova
authors.forename: V I
authors.initials: VI
authors.lastname: Chernov
authors.forename: R S
authors.initials: RS
authors.lastname: Karpov
authors.forename: E V
authors.initials: EV
authors.lastname: Vorob'eva
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Poponina
mesh_terms: D000787:Angina Pectoris / Q000150:complications / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004110:Diltiazem / Q000627:therapeutic use*; D006801:Humans; D007022:Hypotension / Q000150:complications; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D016896:Treatment Outcome; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem