Probing the interaction of the biotin-avidin complex with the relaxivity of biotinylated Gd-DTPA.
A biotinylated Gd-DTPA complex is designed to study the biotin-avidin complexation using the longitudinal relaxivity of this new MRI label, which illustrates the use of MRI contrast agents to probe the formation of supramolecular assemblies in water.
Langereis
Sander
S
Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Kooistra
Homme-Auke T
HA
van Genderen
Marcel H P
MH
Meijer
E W
EW
D001360:Avidin / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D019786:Gadolinium DTPA / Q000138:chemical synthesis / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D015394:Molecular Structure; D017433:Protein Structure, Secondary; D014867:Water / Q000737:chemistry
D003287:Contrast Media; D014867:Water; D001360:Avidin; D001710:Biotin; D019786:Gadolinium DTPA