BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice.
Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BMP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin.
Yuhki
Munehiro
M
Laboratory for Cell Culture Development, RIKEN Brain Science Institute, Saitama 351-0198, Japan.
Yamada
Masahisa
M
Kawano
Masako
M
Iwasato
Takuji
T
Itohara
Shigeyoshi
S
Yoshida
Hisahiro
H
Ogawa
Masaharu
M
Mishina
Yuji
Y
D000818:Animals; D052005:Bone Morphogenetic Protein Receptors, Type I; D002454:Cell Differentiation / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000096:biosynthesis / Q000235:genetics; D018859:Hair Follicle / Q000002:abnormalities / Q000473:pathology / Q000502:physiology*; D053823:Hedgehog Proteins; D019426:Integrases / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D053823:Hedgehog Proteins; D017978:Receptors, Growth Factor; C465570:Shh protein, mouse; D015534:Trans-Activators; D014764:Viral Proteins; D051176:beta Catenin; D017346:Protein Serine-Threonine Kinases; C498212:Bmpr1a protein, mouse; D052005:Bone Morphogenetic Protein Receptors, Type I; C045073:Cre recombinase; D019426:Integrases