title: Acetylated flavonoid glycosides potentiating NGF action from Scoparia dulcis.
abstract: Three new acetylated flavonoid glycosides, 5,6,4'-trihydroxyflavone 7-O-alpha-L-2,3-di-O-acetylrhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (1), apigenin 7-O-alpha-L-3-O-acetylrhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (2), and apigenin 7-O-alpha-L-2,3-di-O-acetylrhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (3), were isolated from Scoparia dulcis together with the known compound eugenyl beta-D-glucopyranoside (4). Their structures were elucidated by spectroscopic analyses. Compounds 2 and 3 showed an enhancing activity of nerve growth factor-mediated neurite outgrowth in PC12D cells.
authors.affiliation: Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Xigui
authors.initials: X
authors.lastname: Chen
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Yasukatsu
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
mesh_terms: D000107:Acetylation; D000818:Animals; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007564:Japan; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000502:physiology*; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D036721:Scoparia / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005419:Flavonoids; D006027:Glycosides; D020932:Nerve Growth Factor