title: Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.
abstract: A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.
authors.affiliation: University of Alabama School of Medicine, Birmingham, Alabama 35233, USA.
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Keith
authors.forename: William B
authors.initials: WB
authors.lastname: Wan
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Ciesla
authors.forename: James R
authors.initials: JR
authors.lastname: Beadle
authors.forename: Karl Y
authors.initials: KY
authors.lastname: Hostetler
authors.forename: Earl R
authors.initials: ER
authors.lastname: Kern
mesh_terms: D000478:Alkylation; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000077404:Cidofovir; D015608:Cowpox virus / Q000187:drug effects; D003500:Cyclization; D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D018155:Orthopoxvirus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014616:Vaccinia virus / Q000187:drug effects; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir