[Cytokine status in patients with chronic obstructive pulmonary diseases and its relationship with bone tissue functional state].
OBJECTIVE
To study cytokine status in patients with chronic obstructive pulmonary disease (COPD) and its interrelations with bone metabolism.


METHODS
The levels of pro-inflammatory and anti-inflammatory cytokines, bone metabolism markers in the blood were evaluated in 80 patients with COPD.


RESULTS
Changes in cytokine status in COPD patients was established: an increase in pro-inflammatory cytokines and change in anti-inflammatory cytokines. There was hyperproduction of serum proinflammatroy cytokines (IL-1 beta, IL-6, IL-8, TNF-alpha) dependent on FEV1. IL-10 was markedly elevated (p < 0.05) while IL-4 had a trend to elevation (p > 0.05) in patients with COPD. A correlation analysis showed a positive correlation between IL-10, IL-4 and FEV1; IL-10, IL-4 and osteocalcine (bone formation marker), pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF alpha) and Crosslaps (bone resorption marker). A negative correlation was discovered between IL-1 beta, TNF alpha and body mass index; IL-8 and osteocalcine.


CONCLUSIONS
A significant role of cytokine-mediated mechanism in pathogenesis of pulmonogenic osteopenia.
Kochetkova
E A
EA
Volkova
M V
MV
Surovenko
T N
TN
Gel'tser
B I
BI
D001842:Bone and Bones / Q000378:metabolism*; D016207:Cytokines / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000502:physiology
D016207:Cytokines; D015675:Osteocalcin