title: New diterpenes from Croton insularis.
abstract: Two new diterpenes (1 and 2) have been isolated from the aerial parts of Croton insularis. Their structures have been established by NMR and mass spectral data, and the absolute configuration of 1 and related trachylobane diterpenes was determined through a series of chemical correlations.
authors.affiliation: Laboratory of Pharmacognosy, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece.
authors.forename: Konstantia
authors.initials: K
authors.lastname: Graikou
authors.forename: Nektarios
authors.initials: N
authors.lastname: Aligiannis
authors.forename: Alexios-Léandros
authors.initials: AL
authors.lastname: Skaltsounis
authors.forename: Ioanna
authors.initials: I
authors.lastname: Chinou
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.forename: François
authors.initials: F
authors.lastname: Tillequin
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D015394:Molecular Structure; D009510:New Caledonia; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C485924:crotinsularin; C485923:ent-trachyloban-3-one