Beryllium(II) binding to ATP and ADP: potentiometric determination of the thermodynamic constants and implications for in vivo toxicity.
Highly toxic beryllium(II) is divalent metal ion with a high charge density, making it a potential target for binding to bio-molecules rich in O donor groups. In aqueous solution Be2+ binds to ATP and ADP to form 1:1 Be2+:ATP and Be2+:ADP complexes in relatively acidic media. At neutral pH the complex formed undergoes hydrolysis. Be2+ binding to ATP and ADP is much stronger than Ca2+ and Mg2+ binding. The high affinity of Be2+ toward ATP and ADP binding suggests a mechanism relevant to understanding the in vivo chemical toxicity of this metal.
Boukhalfa
Hakim
H
Department of Chemistry, Duke University, Box 90346, Durham, NC 27708-0346, USA.
Lewis
James G
JG
Crumbliss
Alvin L
AL
D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D001608:Beryllium / Q000378:metabolism* / Q000633:toxicity; D007700:Kinetics; D012972:Sodium Hydroxide; D013816:Thermodynamics
D012972:Sodium Hydroxide; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D001608:Beryllium