[Effect of adiachrome on the lipid metabolism in experimental diabetes mellitus].
The effect of a new original hypoglycemic peroral drug adiachrome on the lipid metabolism was studied in experimental animals with alloxan induced diabetes. The drug action was evaluated in terms of the levels of ketone bodies, lipoprotein complexes, cholesterol, and malonic dialdehyde in the blood serum. Administered in a dose of 15 mg/kg, adiachrome decreased the level of ketone bodies, lipoproteins, cholesterol, and malonic dialdehyde in the blood serum in dynamics of the model pathology studied.
Maloshtan
L N
LN
National Pharmaceutical University, ul. Pushkinskaya 53, 61002 Kharkov, Ukraine.
Sadek
Omar
O
Khilia
V P
VP
Kovalev
V N
VN
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002867:Chromones / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007657:Ketone Bodies / Q000097:blood; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D011817:Rabbits; D013844:Thiazoles / Q000627:therapeutic use*
D002867:Chromones; D007004:Hypoglycemic Agents; D007657:Ketone Bodies; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D013844:Thiazoles; C487618:adiachrome; D008315:Malondialdehyde; D002784:Cholesterol