Redox metals in Alzheimer's disease.
Redox metals in the brain play many important roles in maintenance of cellular function. The maintenance of their homeostasis is of paramount importance to a number of diseases such as Alzheimer's disease and multiple sclerosis. Iron, copper, and zinc are metals of special interest in the pathogenesis of these disorders. This review will focus primarily on iron.
Todorich
Bozho M
BM
George M. Leader Family Laboratory for Alzheimer's Disease Research, Department of Neural and Behavioral Sciences, Pennsylvania State University School of Medicine, Hershey 17033, USA.
Connor
James R
JR
D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D002614:Chelating Agents / Q000627:therapeutic use; D003300:Copper / Q000378:metabolism; D006432:Hemochromatosis / Q000150:complications / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D010084:Oxidation-Reduction; D015032:Zinc / Q000378:metabolism
D002614:Chelating Agents; D008670:Metals; D003300:Copper; D007501:Iron; D015032:Zinc