[Does tumor angiogenesis play a role in bone metastatic process?].
Angiogenesis plays an important role in the regulation of tumor growth and metastasis of numerous cancers. However, the role of angiogenesis in the bone metastasis process is totally unknown. Using an experimental model of bone metastasis caused by MDA-MB-231/B02 breast cancer cells in nude mice, we show that beside its well-know anti-angiogenic activity, angiostatin inhibits bone metastasis formation through a direct antiosteoclastic activity.
Peyruchaud
Olivier
O
INSERM Research Unit 403 Faculté de Médecine Laënnec Rue Guillaume Paradin F-69372 Lyon. peyruchaud@lyon.inserm.fr
Serre
Claire-Marie
CM
NicAmhlaoibh
Roisin
R
Sveigaard
Christine
C
Clézardin
Philippe
P
D000818:Animals; D001859:Bone Neoplasms / Q000556:secondary*; D045744:Cell Line, Tumor; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000556:secondary*; D009389:Neovascularization, Pathologic