New benzo[5,6]pyrrolizino[1,2-b]quinolines as cytotoxic agents.
An assessment of structure-activity relationships associated with the new benzo[5,6]pyrrolizino[1,2-b]quinoline system displaying potent in vitro cytotoxic activity against the MCF7 cell line is described.
Perzyna
Aurore
A
Institut de Chimie Pharmaceutique Albert Lespagnol, EA 2692, Université de Lille, 2, rue du Professeur Laguesse, BP 83, 59006 Lille, France.
Klupsch
Frédérique
F
Houssin
Raymond
R
Pommery
Nicole
N
Lemoine
Amélie
A
Hénichart
Jean-Pierre
JP
D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011804:Quinolines / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011804:Quinolines