title: Pesticide-induced impairment of thyroid physiology in the freshwater catfish, Heteropneustes fossilis.
abstract: Effects of BHC (8 mg litre(-1)) and malathion (10 mg litre(-1)) exposure for 96 h have been studied on T(3) and T(4) concentrations in plasma, and in pharyngeal thyroid tissue preparations. Thyroid peroxidase (TPO) activity in the pharyngeal thyroid tissue, along with the extra-thyroidal conversion of T(4) into T(3) were measured in a freshwater catfish, Heteropneustes fossilis. BHC stimulated TPO activity in this fish, during both in vitro and in vivo studies. In contrast, malathion was found to stimulate TPO activity during the in vitro experiments but to inhibit it in the in vivo study. Concentrations of T(3) and T(4) increased in the thyroid gland, as well as in the plasma, in response to BHC exposure. However, in both these tissues, malathion increased T(3) concentrations and reduced T(4) concentrations. The extrathyroidal conversion of T(4) into T(3) was stimulated by malathion and inhibited by BHC.
authors.affiliation: Department of Zoology, Fish Endocrinology Laboratory, Banaras Hindu University, Varanasi-221005, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Yadav
authors.forename: T P
authors.initials: TP
authors.lastname: Singh