Choreic syndrome and coeliac disease: a hitherto unrecognised association.
Coeliac disease has been associated with a variety of neurological conditions, most frequently cerebellar ataxia and peripheral neuropathy. To date, chorea has not been associated with coeliac disease. We present the case histories of 4 individuals with coeliac disease and chorea (4 women, average age of onset of chorea 61 years). Unexpectedly, most of these patients showed a notable improvement in their motor symptoms after the introduction of a gluten-free diet.
Pereira
Anthony C
AC
Sobell Dept of Motor Neuroscience and Movement Disorders, Institute of Neurology, United Kingdom.
Edwards
Mark J
MJ
Buttery
Philip C
PC
Hawkes
Christopher H
CH
Quinn
Niall P
NP
Giovannoni
Gavin
G
Hadjivassiliou
Marios
M
Bhatia
Kailash P
KP
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002446:Celiac Disease / Q000150:complications* / Q000175:diagnosis* / Q000378:metabolism; D002819:Chorea / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D003937:Diagnosis, Differential; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D005983:Glutens / Q000378:metabolism; D006683:HLA-DQ Antigens / Q000276:immunology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
D006683:HLA-DQ Antigens; D005983:Glutens