title: Outcome of patients with acute myeloid leukemia and pulmonary infiltrates requiring invasive mechanical ventilation-a retrospective analysis.
abstract: OBJECTIVE
  To assess the prognosis of patients with acute myeloid leukemia (AML) and pulmonary infiltrates requiring mechanical ventilation.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  A medical intensive care unit (ICU) in an academic tertiary care center.
  
  
  METHODS
  We identified 30 consecutive patients with acute myeloid leukemia and pulmonary infiltrates who received invasive mechanical ventilation and compared clinical and laboratory parameters between ICU survivors and ICU non-survivors using non-parametric statistics.
  
  
  RESULTS
  The overall mortality rate was 87% (26/30). The survival was 40 % (4/10) for patients aged 50 years or less while none (0/20) of the patients older than 50 years survived (P <.02). The median time of mechanical ventilation in survivors was 23.5 (3-45) days. No differences between survivors and non-survivors were observed for the APACHE II score, oxygenation quotient, liver function tests, creatinine, blood urea nitrogen, or prognostic parameters of acute myeloid leukemia (presence of blasts on bone marrow aspirate, cytogenetic studies, and intensity of the chemotherapy regimen).
  
  
  CONCLUSIONS
  Age seems to be an important prognostic parameter in our cohort of 30 consecutive patients with acute myeloid leukemia and pulmonary infiltrates requiring mechanical ventilation. Prolonged ventilation does not preclude survival.
authors.affiliation: Department of Medicine, University of Bonn, Germany. Rabe@uni-bonn.de
authors.forename: Christian
authors.initials: C
authors.lastname: Rabe
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mey
authors.forename: Michael
authors.initials: M
authors.lastname: Paashaus
authors.forename: Annemarie
authors.initials: A
authors.lastname: Musch
authors.forename: Selcuk
authors.initials: S
authors.lastname: Tasci
authors.forename: Axel
authors.initials: A
authors.lastname: Glasmacher
authors.forename: Ingo G h
authors.initials: IG
authors.lastname: Schmidt-Wolf
authors.forename: Tilman
authors.initials: T
authors.lastname: Sauerbruch
authors.forename: Franz Ludwig
authors.initials: FL
authors.lastname: Dumoulin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000401:mortality* / Q000628:therapy*; D008171:Lung Diseases / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis