Hemolysis following an out-of-group platelet transfusion in an 8-month-old with Langerhans cell histiocytosis.
This article describes an 8-month-old boy with Langerhans cell histiocytosis and A-positive blood group who developed a febrile hemolytic transfusion reaction with hepatic and renal failure leading to his death secondary to hemolysis from an out-of-group platelet transfusion from an O-positive donor. High-titer anti-A antibody caused the hemolysis. Volume reduction of out-of-group platelets should be considered, particularly when single-donor platelet pheresis platelets are used in children with small plasma volumes.
Angiolillo
Anne
A
George Washington University School of Medicine and Children's National Medical Center, Washington, DC 20010, USA. aangioli@cnmc.org
Luban
Naomi L C
NL
D000017:ABO Blood-Group System; D001810:Blood Volume; D017809:Fatal Outcome; D006400:Hematocrit; D006461:Hemolysis; D006646:Histiocytosis, Langerhans-Cell / Q000097:blood* / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D017713:Platelet Transfusion / Q000009:adverse effects*
D000017:ABO Blood-Group System