[Reduced intensity stem cell transplantation for metastatic renal cell carcinoma].
OBJECTIVE
We reviewed reduced intensity stem cell transplantation (RIST) in metastatic renal cell cancer (RCC).


METHODS
Two cases of lung metastasis of immunotherapy invalidity. Six days of fludarabine 30 mg/m2 and 2 days of busulfan 4 mg/kg were given as conditioning for mini-SCT. CyA and short-term MTX were used as immunosuppressive agents.


RESULTS
Size reduction of tumor was observed with dose reduction of CyA. Following steroid therapy for the treatment of GVHD, the tumor progressed. No serious complications except for GVHD.


CONCLUSIONS
These results suggested that RIST might be considered as salvage therapy in patients metastatic RCC.
Omori
So
S
Department of Urology, Iwate Medical University.
Fujioka
Tomoaki
T
Ono
Yoko
Y
Numaoka
Hideharu
H
Ishida
Yoji
Y
D000328:Adult; D002066:Busulfan / Q000008:administration & dosage; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D016572:Cyclosporine / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D016879:Salvage Therapy; D033581:Stem Cell Transplantation / Q000379:methods*; D018183:Transplantation Chimera; D019172:Transplantation Conditioning; D014740:Vidarabine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D014740:Vidarabine; D002066:Busulfan; C024352:fludarabine; D008727:Methotrexate