Kumada-Corriu reactions of alkyl halides with alkynyl nucleophiles.
[reaction: see text] Pd(2)(dba)(3)-Ph(3)P-catalyzed Kumada-Corriu coupling reactions of unactivated alkyl bromides or iodides with an alkynyl nucleophile furnish C(sp)-C(sp)3 bond formation. Alkynyl nucleophiles can be alkynyllithiums or the corresponding Grignard reagents. The superior performance of Ph(3)P ligand over the trialkylphosphine ligands indicates that this cross-coupling reaction may be a reductive-elimination-controlled process.
Yang
Lian-Ming
LM
Department of Chemistry and Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan.
Huang
Li-Fu
LF
Luh
Tien-Yau
TY