A comparison of two intensities of psychosocial intervention for alcohol dependent patients treated with acamprosate.
OBJECTIVE
To compare two levels of psychosocial intervention in combination with acamprosate medication for the treatment of alcohol dependence.


METHODS
Patients (n = 70) were prescribed acamprosate and randomized to Minimal Psychosocial Intervention (MPI) or Extended Psychosocial Intervention (EPI). MPI patients met a psychiatrist for 20-30 min sessions on four occasions during a 6 month period. EPI patients were offered 10-15 sessions with a psychiatric nurse in addition to the visits to the psychiatrist. EPI patients were trained to use behavioural and cognitive coping skills to deal with high-risk situations in line with a manual developed for relapse prevention. Patients were assessed four times during the 24-week study by self-report and laboratory tests.


RESULTS
Patients on average reported a decline in days with heavy drinking and in cumulative number of drinking days. No significant differences between patients in MPI and EPI were found with respect to heavy drinking, cumulative number of drinking days, number of days to first drink, or biomarkers of alcohol consumption. Higher age and lower level of education were significant predictors of treatment success.


CONCLUSIONS
Adding more intensive individual treatments appears to add no extra improvement beyond that obtained by prescribing acamprosate and offering an infrequent consultation with a physician.
Hammarberg
Anders
A
Department of Clinical Neuroscience, Alcohol and Drug Dependence Research, Karolinska Institutet, Stockholm. anders.hammarberg@previa.se
Wennberg
Peter
P
Beck
Olof
O
Franck
Johan
J
D000077443:Acamprosate; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000188:drug therapy / Q000523:psychology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011613:Psychotherapy / Q000379:methods* / Q000706:statistics & numerical data; D012944:Social Support; D012959:Socioeconomic Factors; D013654:Taurine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D013654:Taurine; D000077443:Acamprosate