title: Factors associated with liver steatosis and fibrosis in chronic hepatitis C patients.
abstract: Liver steatosis is a common finding in patients infected with hepatitis C virus (HCV). Host and viral factors have been associated with steatosis, but their relative contributions have not been clearly addressed. It has been suggested that steatosis plays a role in the progression of liver fibrosis.
  
  
  OBJECTIVE
  To assess: a) factors associated with steatosis in patients infected with hepatitis C virus; b) their impact on liver fibrosis.
  
  
  METHODS
  Three hundred and fourteen untreated patients were included. Lifetime alcohol consumption was estimated. Liver fibrosis, inflammation and necrosis were assessed using the METAVIR score. Body mass index (BMI) was determined. The scoring system for steatosis was as follows: 0, no steatosis; 1, less than 10%; 2, 10% to 30%; 3, 30% to 70%; 4, more than 70% of hepatocytes affected.
  
  
  RESULTS
  In univariate analysis, steatosis was associated with elevated BMI (P=0.001), excessive alcohol intake (P=0.005), genotype 3 (P<0.001) and moderate to severe histological activity (P=0.01). Multivariate analysis showed that steatosis correlated with two independent factors: genotype 3a (OR=60.7; 95% CI: 7.6-483.4) (P<0.001) and BMI (OR=4.86; 95% CI: 1.8-13.15) (P=0.002). In univariate analysis, severe fibrosis (F2-F3-F4) was associated with older age (P<10(-5)), male gender (P=0.001), disease duration (P<0.006), BMI (P<10(-4)), alcohol intake (P<10(-6)), severity of histological activity (P<10(-5)) and steatosis (P<10(-6)). In multivariate analysis, three independent factors were associated with severe fibrosis: disease duration > 10 years (OR=3.17; 95% CI: 0.65-15.4) (P=0.015), presence of steatosis (OR=3.17; 95% CI: 1-9.99) (P<0.049) and genotype 3a (OR=5.56; 95% CI: 1.4-22.1) (P=0.015).
  
  
  CONCLUSIONS
  In patients with chronic hepatitis C, steatosis is significantly associated with genotype 3 infection and high BMI. Steatosis is an independent risk factor associated with severe fibrosis. These results have major implications for the management of patients with chronic hepatitis C.
authors.affiliation: Service d'Hépato-Gastroentérologie, CHU La Cavale Blanche 29609 Brest Cedex.
authors.forename: Franck
authors.initials: F
authors.lastname: Cholet
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Nousbaum
authors.forename: Martial
authors.initials: M
authors.lastname: Richecoeur
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Oger
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Cauvin
authors.forename: Nicole
authors.initials: N
authors.lastname: Lagarde
authors.forename: Michel
authors.initials: M
authors.lastname: Robaszkiewicz
authors.forename: Hervé
authors.initials: H
authors.lastname: Gouérou
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D015331:Cohort Studies; D005234:Fatty Liver / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors