Oxygen-dependent mechanisms underlying the antiischemic effect of verapamil and amlodipine.
Verapamil and amlodipine produced a potent antiischemic effect and reduced the area of myocardial infarction in rats. The observed changes were accompanied by inhibition of lipid peroxidation. In contrast to verapamil, amlodipine in a dose of 50 ng/ml in vitro decreased hemoglobin affinity for oxygen. Moreover, amlodipine in a concentration of 2 ng/ml decreased the content of malonic dialdehyde and activity of superoxide dismutase in the blood.
Gatsura
S V
SV
Russian State Medical University, Moscow. svg@medicina.ru
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D006454:Hemoglobins / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D009203:Myocardial Infarction / Q000097:blood*; D017202:Myocardial Ischemia / Q000097:blood; D010100:Oxygen / Q000097:blood*; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood; D014700:Verapamil / Q000494:pharmacology*
D006454:Hemoglobins; D017311:Amlodipine; D008315:Malondialdehyde; D014700:Verapamil; D013482:Superoxide Dismutase; D010100:Oxygen