title: Angiotensin-related genes in patients with panic disorder.
abstract: Enhanced respiratory variability and decreased heart rate variability have repeatedly been observed in patients with panic disorder. Prompted by the notion that angiotensin may be involved in the control of respiration, heart rate variability, and anxiety-like behavior, we investigated the putative association between polymorphisms in three angiotensin-related genes and panic disorder-angiotensinogen (AGT), angiotensin converting enzyme (ACE), and angiotensin II (ANG II) receptor type 1 (ATr1) in 72 patients with panic disorder and 504 controls. Allele and genotype distribution of the ATr1 A1166C allele and the AGT M235T did not differ between patients and controls. With respect to the ACE I/D polymorphism, the I allele was found to be more frequent in male (chi(2) = 8.042, df = 1, P = 0.005), but not female, panic disorder patients than in controls. The results of this investigation provide preliminary evidence for the suggestion that angiotensin-related genes may be associated with panic disorder in men.
authors.affiliation: Department of Pharmacology, Göteborg University, Gothenburg, Sweden. marie.olsson@pharm.gu.se
authors.forename: Marie
authors.initials: M
authors.lastname: Olsson
authors.forename: Kristina
authors.initials: K
authors.lastname: Annerbrink
authors.forename: Lars
authors.initials: L
authors.lastname: Westberg
authors.forename: Jonas
authors.initials: J
authors.lastname: Melke
authors.forename: Fariba
authors.initials: F
authors.lastname: Baghaei
authors.forename: Roland
authors.initials: R
authors.lastname: Rosmond
authors.forename: Göran
authors.initials: G
authors.lastname: Holm
authors.forename: Sven
authors.initials: S
authors.lastname: Andersch
authors.forename: Christer
authors.initials: C
authors.lastname: Allgulander
authors.forename: Elias
authors.initials: E
authors.lastname: Eriksson
mesh_terms: D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D016584:Panic Disorder / Q000235:genetics* / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics*
chemical_list: D044140:Receptor, Angiotensin, Type 1; D000808:Angiotensinogen; D004247:DNA; D007703:Peptidyl-Dipeptidase A