The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough.
Desulfovibrio vulgaris Hildenborough is a model organism for studying the energy metabolism of sulfate-reducing bacteria (SRB) and for understanding the economic impacts of SRB, including biocorrosion of metal infrastructure and bioremediation of toxic metal ions. The 3,570,858 base pair (bp) genome sequence reveals a network of novel c-type cytochromes, connecting multiple periplasmic hydrogenases and formate dehydrogenases, as a key feature of its energy metabolism. The relative arrangement of genes encoding enzymes for energy transduction, together with inferred cellular location of the enzymes, provides a basis for proposing an expansion to the 'hydrogen-cycling' model for increasing energy efficiency in this bacterium. Plasmid-encoded functions include modification of cell surface components, nitrogen fixation and a type-III protein secretion system. This genome sequence represents a substantial step toward the elucidation of pathways for reduction (and bioremediation) of pollutants such as uranium and chromium and offers a new starting point for defining this organism's complex anaerobic respiration.
Heidelberg
John F
JF
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA. dvu@tigr.org
Seshadri
Rekha
R
Haveman
Shelley A
SA
Hemme
Christopher L
CL
Paulsen
Ian T
IT
Kolonay
James F
JF
Eisen
Jonathan A
JA
Ward
Naomi
N
Methe
Barbara
B
Brinkac
Lauren M
LM
Daugherty
Sean C
SC
Deboy
Robert T
RT
Dodson
Robert J
RJ
Durkin
A Scott
AS
Madupu
Ramana
R
Nelson
William C
WC
Sullivan
Steven A
SA
Fouts
Derrick
D
Haft
Daniel H
DH
Selengut
Jeremy
J
Peterson
Jeremy D
JD
Davidsen
Tanja M
TM
Zafar
Nikhat
N
Zhou
Liwei
L
Radune
Diana
D
Dimitrov
George
G
Hance
Mark
M
Tran
Kevin
K
Khouri
Hoda
H
Gill
John
J
Utterback
Terry R
TR
Feldblyum
Tamara V
TV
Wall
Judy D
JD
Voordouw
Gerrit
G
Fraser
Claire M
CM
D016969:Desulfovibrio vulgaris / Q000235:genetics* / Q000378:metabolism; D004734:Energy Metabolism; D016680:Genome, Bacterial; D008969:Molecular Sequence Data