Antagonistic pleiotropy for life-history traits at the gene expression level.
Life-history trade-offs prevent different components of fitness from being maximized simultaneously. Although the existence of trade-offs has been clearly demonstrated, the 'classical' mechanism of adaptive resource allocation that should underlie them has recently received criticism. In this study, we explore the molecular mechanisms of life-history trade-offs by applying a quantitative genomic approach. Analysis of global gene expression in Drosophila melanogaster revealed 34 genes whose expression coincided with the genetic trade-off between larval survival and adult size. The joint expression of these candidate 'trade-off' genes explained 86.3% of the trade-off. Fourteen of these genes have known functions which suggest that the larval survival-adult size trade-off could be the result of resource allocation at the organismal level, but at the level of cellular metabolism the trade-off would reduce to a shift between energy metabolism versus protein biosynthesis, regulated by the RAS signalling pathway.
Bochdanovits
Zoltán
Z
Evolutionary Population Biology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. z.bochdanovits@bio.uu.nl
de Jong
Gerdien
G
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001824:Body Constitution; D003364:Costa Rica; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D015870:Gene Expression; D007814:Larva / Q000254:growth & development; D008018:Life Cycle Stages / Q000502:physiology*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D014861:Washington