Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP.
It is generally believed that multiple Ca2+ stores are present in cells, a notion that has now been made substantive by the discovery of multiple Ca2+ mobilizing messengers. Cyclic ADP-ribose (cADPR) and nicotinic acid dinucleotide phosphate (NAADP) are two such messengers that are derived from NAD and NADP, respectively. A wide variety of cells, from plants to mammals, including human, have been shown to be responsive to these two novel Ca2+ messengers. Not only are their structures and mechanisms of action different, their targeted Ca2+ stores are also distinct and separable. This article explores the implications of the multiplicity of Ca2+ stores in cellular signaling. Special emphasis will be put on the recent progress in the understanding of the physiological functions of NAADP.
Lee
Hon Cheung
HC
University of Minnesota, Department of Pharmacology, Minneapolis, MN 55455, USA. leehc@maroon.tc.umn.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002384:Catalysis; D036563:Cyclic ADP-Ribose / Q000378:metabolism*; D006801:Humans; D009249:NADP / Q000031:analogs & derivatives / Q000378:metabolism*
D036563:Cyclic ADP-Ribose; D009249:NADP; C024376:NAADP; D002118:Calcium