title: Optical encoding with shaped DAM-1 molecular sieve particles.
abstract: This work introduces a new high-throughput screening particle - a Dallas Amphorous Material No. 1 (DAM-1) molecular sieve particle. In contrast to porous silica microspheres, the 2-8-microm sized DAM-1 molecular sieve particles are available in a variety of shapes and morphologies including spheres, hexagons, rods, gyroids, and discoids. The advantage of using DAM-1 molecular sieve particles is the ability to encode an array by particle shape, which in turn permits the repeated use of luminescent reporter dyes. In this technical note, we demonstrate optical decoding of fluorescein- and Texas Red-modified shaped molecular sieve particles using reflectance and fluorescence microscopies.
authors.affiliation: Department of Chemistry, The University of Texas at Dallas, Richardson, TX 75083-0688, USA. pantano@utdallas.edu
authors.forename: Paul
authors.initials: P
authors.lastname: Pantano
authors.forename: Claudia C
authors.initials: CC
authors.lastname: Meek
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Decio H
authors.initials: DH
authors.lastname: Coutinho
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Balkus
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D016650:Fluorescein-5-isothiocyanate / Q000032:analysis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry; D008832:Microchemistry; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008856:Microscopy, Fluorescence; D015335:Molecular Probes / Q000032:analysis; D011092:Polyethylene Glycols / Q000737:chemistry; D016062:Porosity; D017655:Silicon Compounds / Q000737:chemistry*; D013386:Succinates / Q000737:chemistry; D014810:Vitamin E / Q000031:analogs & derivatives; D014966:Xanthenes / Q000032:analysis / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D015335:Molecular Probes; D017655:Silicon Compounds; D013386:Succinates; D014966:Xanthenes; D014810:Vitamin E; D011092:Polyethylene Glycols; C034657:Texas red; D016650:Fluorescein-5-isothiocyanate