The effect of the Melissa officinalis extract on immune response in mice.
The effect of an extract from Melissa officinalis on immune response in mice was analysed using the cytotoxicity test in three dilutions (undiluted extract and extract diluted 10 and 100 times) and hemagglutination and rosette tests with various routes of administration (oral and subcutaneous). The immunostimulating activity of the extract was compared with that of a synthetic compound--levamisole, which influence on the immune system is well known. The present results confirm the effect of water extracts from leaves of Melissa on the immune system, in both humoral and cellular response.
Drozd
Janina
J
Department of Biochemistry and Biopharmaceuticals, National Institute of Public Health, 30/34 Chełmska Str., 00-725 Warszawa.
Anuszewska
Elzbieta
E
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D005260:Female; D031334:Melissa / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D010936:Plant Extracts