Functional polymorphisms in LPS receptors CD14 and TLR4 are not associated with disease susceptibility or Campylobacter jejuni infection in Guillain-Barré patients.
Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy preceded by infections. Campylobacter jejuni is the most frequent pathogen and its lipopolysaccharide (LPS) induces antibodies cross-reactive with gangliosides. In this study we assessed whether known functional polymorphisms in the LPS receptors CD14 and Toll-like receptor 4 (TLR4) are associated with an increased susceptibility for GBS or with C. jejuni serology or C. jejuni related clinical and serological features. Comparison of the genotypes of 242 GBS patients and 210 healthy subjects showed that polymorphisms in CD14 and TLR4 did not confer disease susceptibility and were not associated with C. jejuni infection.
Geleijns
Karin
K
Department of Immunology, Erasmus Medical Centre, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. c.geleijns@erasmusmc.nl
Jacobs
Bart C
BC
Van Rijs
Wouter
W
Tio-Gillen
Anne P
AP
Laman
Jon D
JD
van Doorn
Pieter A
PA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood; D002169:Campylobacter Infections / Q000150:complications / Q000235:genetics / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology*; D002648:Child; D004185:Disability Evaluation; D005260:Female; D005732:Gangliosides / Q000276:immunology; D020022:Genetic Predisposition to Disease; D020275:Guillain-Barre Syndrome / Q000150:complications / Q000235:genetics / Q000276:immunology*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics* / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000235:genetics*; D012698:Serologic Tests; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D001323:Autoantibodies; D005732:Gangliosides; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors