Relation between axial length of the eye and hypotensive effect of latanoprost in primary open angle glaucoma.
OBJECTIVE
To study the effect of axial length on the hypotensive effect of latanoprost in primary open angle glaucoma (POAG) in a prospective, observational study.


METHODS
The authors measured axial length and baseline intraocular pressure (IOP) of 109 eyes with POAG, and then repeated the IOP measurements at 1, 3, and 6 months after starting treatment with latanoprost.


RESULTS
The mean IOP level was significantly lower in eyes with a shorter axial length compared with the eyes with a longer axial length both at 3 and 6 months of treatment (p = 0.03 and p = 0.04, respectively, ANOVA).


CONCLUSIONS
The hypotensive effect resulting from treatment with latanoprost could be related to ocular axial length.
Arranz-Marquez
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University of Alcalá, Hospital Oftalmológico Internacional de Madrid. esther-arranz@ole.com
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D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001699:Biometry; D005123:Eye / Q000473:pathology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost