Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.
The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.
Thérien
Michel
M
Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Quebec, Pointe Claire--Dorval, Canada H9R 4P8. michel_therien@merck.com
Skorey
Kathryn
K
Zamboni
Robert
R
Li
Chun Sing
CS
Lau
Cheuk K
CK
LeRiche
Tammy
T
Linh Truong
Vouy
V
Waddleton
Deena
D
Ramachandran
Chidambaram
C
D019920:Photoaffinity Labels / Q000138:chemical synthesis* / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry*
D019920:Photoaffinity Labels; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases