Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues.
A series of 7-deoxy discodermolide analogues in which the lactone fragment 'C' was replaced by aryl substituents were designed, synthesized, and evaluated for cytotoxicity.
Burlingame
Mark A
MA
Department of Chemistry, Kosan Biosciences Inc, 3832 Bay Center Place, Hayward, CA 94545, USA. burlingame@kosan.com
Shaw
Simon J
SJ
Sundermann
Kurt F
KF
Zhang
Dan
D
Petryka
Joseph
J
Mendoza
Esteban
E
Liu
Fenghua
F
Myles
David C
DC
LaMarche
Matthew J
MJ
Hirose
Tomoyasu
T
Scott Freeze
B
B
Smith
Amos B
AB
D000473:Alkanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011753:Pyrones
D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007783:Lactones; D011753:Pyrones; C071229:discodermolide