In vitro-in vivo antifungal evaluation and structure-activity relationships of 3H-1,2-dithiole-3-thione derivatives.
As part of our project devoted to the search of new antifungal agents, we report here the in vitro-in vivo antifungal evaluations and a structure-activity relationship (SAR) study of 17 thione derivatives. Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the biological response.
Giannini
Fernando A
FA
Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis (UNSL), Chacabuco y Pedernera, San Luis 5700, Argentina.
Aimar
Mario L
ML
Sortino
Maximiliano
M
Gomez
Roxana
R
Sturniollo
Alejandro
A
Juarez
Americo
A
Zacchino
Susana
S
de Rossi
Rita H
RH
Enriz
Ricardo D
RD
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000627:therapeutic use; D006168:Guinea Pigs; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013329:Structure-Activity Relationship; D013871:Thiones / Q000737:chemistry* / Q000627:therapeutic use; D013876:Thiophenes / Q000737:chemistry* / Q000627:therapeutic use; D014005:Tinea / Q000188:drug therapy; D014316:Tritium / Q000737:chemistry
D000935:Antifungal Agents; D013871:Thiones; D013876:Thiophenes; D014316:Tritium; C049325:1,2-dithiol-3-thione