Atherosclerosis in the apolipoprotein-E-deficient mouse: a decade of progress.
Arguably the most critical advancement in the elucidation of factors affecting atherogenesis has been the development of mouse models of atherosclerosis. Among available models, the apolipoprotein E-deficient (apoE-/-) mouse is particularly popular because of its propensity to spontaneously develop atherosclerotic lesions on a standard chow diet. A Medline search reveals over 645 articles dedicated to studies using this reliable and convenient "super" animal model since its inception (Piedrahita JA et al, Proc Natl Acad Sci U S A 1992;89:4471-4475; Plump AS et al, Cell 1992;71:343-353) with a more or less steady increase from year to year. This review will examine our present understanding of the pathology and progression of plaques in this animal and highlight some of the nutritional, pharmacological, and genetic studies that have enhanced this understanding.
Meir
Karen S
KS
Department of Pathology, Hadassah University Hospital, Kiryat Hadassah, Jerusalem, Israel.
Leitersdorf
Eran
E
D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D001161:Arteriosclerosis / Q000178:diet therapy / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D001692:Biological Transport; D001921:Brain / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004041:Dietary Fats / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D005260:Female; D005342:Fibrinolysis; D005487:Foam Cells / Q000378:metabolism / Q000473:pathology; D006938:Hyperlipoproteinemia Type II / Q000150:complications / Q000235:genetics*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism; D051116:Receptors, Scavenger
D001057:Apolipoproteins E; D004041:Dietary Fats; D005227:Fatty Acids; D000960:Hypolipidemic Agents; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D002784:Cholesterol