title: Myocardial viability evaluation using magnetocardiography in patients with coronary artery disease.
abstract: OBJECTIVE
  Magnetocardiography (MCG) has been used to risk stratify patients in terms of sudden death or to detect ischemia. We evaluated the potential of this technique to assess myocardial viability in coronary artery disease.
  
  
  METHODS
  Fifteen patients aged 36-75 (median, 59) years with stable single-vessel disease (> or =70% diameter stenosis) and corresponding regional wall-motion abnormality underwent (1) echocardiography to evaluate wall motion, (2) Tl dipyridamole single-photon emission computed tomography to document perfusion and (3) quantitative F-fluorodeoxyglucose positron emission tomography to assess viability in 16 left-ventricular wall segments. MCG was performed in each patient using a shielded prototype 49-channel low-temperature superconducting quantum interference device (SQUID) system. Multiple time and area parameters were extracted automatically from each baseline-corrected data set.
  
  
  RESULTS
  Eleven patients had prior myocardial infarction. In each patient, four to 12 (median, seven) segments were lesion dependent, totalling up to 117 out of 240 segments. A total of 88 segments (75%) were viable and 29 segments (25%) represented scar. Patients were divided into three categories: (a) no scar segments (five patients), (b) scar in one to three segments (six patients) and (c) scar in > or = four segments (four patients). The three MCG parameters with the best selectivity were identified using linear discriminant analysis with forward inclusion (P<0.10). The corresponding Fisher's discriminant functions classified all patients correctly (Wilks' lambda=0.079).
  
  
  CONCLUSIONS
  Selected MCG parameters yielded accurate patient classification with regard to the extension of myocardial scar within the viable tissue in retrospect. These findings indicate that MCG may contribute to the assessment of myocardial viability. Further evaluation in a comprehensive multicenter study is warranted.
authors.affiliation: Medical Clinic II-Cardiology and Pulmology, Benjamin Franklin University Hospital, Berlin, Germany. amorguet@zedat.fu-berlin.de
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Morguet
authors.forename: Steffen
authors.initials: S
authors.lastname: Behrens
authors.forename: Olaf
authors.initials: O
authors.lastname: Kosch
authors.forename: Christine
authors.initials: C
authors.lastname: Lange
authors.forename: Markus
authors.initials: M
authors.lastname: Zabel
authors.forename: Daniela
authors.initials: D
authors.lastname: Selbig
authors.forename: Dieter L
authors.initials: DL
authors.lastname: Munz
authors.forename: Heinz-Peter
authors.initials: HP
authors.lastname: Schultheiss
authors.forename: Hans
authors.initials: H
authors.lastname: Koch
mesh_terms: D000328:Adult; D000368:Aged; D002921:Cicatrix / Q000175:diagnosis / Q000473:pathology; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D004562:Electrocardiography; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008280:Magnetics / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D012307:Risk Factors; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013793:Thallium; D014022:Tissue Survival; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18; C027549:thallium chloride; D013793:Thallium