Experimental Mycoplasma hominis infection of the genital tract in BALB/c mice.
We studied the ability of laboratory and clinical strains of Mycoplasma hominis to colonize the genital tract mucosa in BALB/c mice. Colonization with mycoplasma occurred only in mice receiving estrogen. Mycoplasma hominis strains obtained after 3-fold passage through the vaginal mucosa in mice and administered intravaginally in a dose of 0.5 x 10(8) CFU/ml caused infection in 100% animals. Inflammation in the lower genital tract was reduced by the 8th week after infection.
Shkarupeta
M M
MM
Institute of Physicochemical Medicine, Russian Ministry of Health, Moscow.
Lazarev
V N
VN
Govorun
V M
VM
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005831:Genital Diseases, Female / Q000382:microbiology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009175:Mycoplasma Infections / Q000382:microbiology* / Q000473:pathology; D019535:Mycoplasma hominis / Q000472:pathogenicity*; D014621:Vagina / Q000382:microbiology* / Q000473:pathology