title: Inhibition of human low density lipoprotein oxidation by flavonols and their glycosides.
abstract: Antioxidative effects of the flavonols and their glycosides, i.e., quercetin (Q), quercetin galactopyranoside (QG), quercetin rhamnolpyranoside (QR), rutin (R), morin (MO), myrecetin (MY), kaempferol (K) and kaempferol glucoside (KG), against free radical initiated peroxidation of human low density lipoprotein (LDL) were studied. The peroxidation was initiated either by a water-soluble initiator 2,2'-azobis(2-amidino propane hydrochloride) (AAPH), or by cupric ion (Cu2+). The reaction kinetics were monitored either by the uptake of oxygen and the depletion of alpha-tocopherol (TOH) presented in the native LDL, or by the formation of thiobarbituric acid reactive substances (TBARS). Kinetic analysis of the antioxidation process demonstrates that these flavonols and their glycosides are effective antioxidants against AAPH- and Cu(2+)-initiated LDL peroxidation, the flavonols bearing ortho-dihydroxyl groups possess significantly higher antioxidant activity than those bearing no such functionalities, and the glycosides are less active than their parent aglycones.
authors.affiliation: National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Hou
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Liu
mesh_terms: D044948:Flavonols / Q000737:chemistry / Q000494:pharmacology*; D005609:Free Radicals / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry*; D010084:Oxidation-Reduction; D024502:alpha-Tocopherol / Q000737:chemistry
chemical_list: D044948:Flavonols; D005609:Free Radicals; D006027:Glycosides; D008077:Lipoproteins, LDL; D024502:alpha-Tocopherol