title: Management of acute dyspnoea: use and feasibility of brain natriuretic peptide (BNP) assay in the prehospital setting.
abstract: OBJECTIVE
  Diagnosis of acute left ventricular failure (LVF) is often difficult in the prehospital setting. Brain natriuretic peptide (BNP) is a marker of LVF. The object of this study was to evaluate the feasibility of BNP measurement during the prehospital management of patients with dyspnoea.
  
  
  METHODS
  Prospective feasibility study, in the Paris Emergency Medical Service (SAMU).
  
  
  METHODS
  All patients, aged 50 years and over, presenting with acute dyspnoea were included in the study, unless the dyspnoea was of circumstantial origin. Bedside BNP assays were conducted in parallel with the usual clinical management. For each patient, three diagnoses (cardiac, respiratory or uncertain) were established: firstly, according to the usual clinical criteria (diagnosis 1); secondly (diagnosis 2) according to the result of BNP measurement. When the diagnoses 1 and 2 were not in agreement, patients were entered into a category labeled "diagnostic correction".
  
  
  RESULTS
  Fifty-two patients were included in the study. Twenty-one patients had clinically obvious LVF (diagnosis 1' = cardiac). For seven other patients, the clinical variables suggested a respiratory cause (diagnosis 1 = respiratory). For 24 patients dyspnoea was due to a non-identified cause (diagnosis 1 = uncertain). BNP levels were measured in 51 out of 52 patients (one failure). Only nine patients had a BNP level lower than the threshold value of 100 pg ml(-1). In 71% the diagnosis 1 was corrected after BNP estimation. Only two of 27 patients with marked bronchospasm had a BNP level lower than 100 pg ml(-1).
  
  
  CONCLUSIONS
  Estimation of BNP is both feasible and easy in prehospital care, and can confirm the cardiac origins of atypical acute dyspnoea. In elderly patients LVF appears to be clinically underestimated. BNP assay may produce improvements in prehospital management of patients with dyspnoea.
authors.affiliation: SAMU of Paris, Necker Hospital, René Descartes University, Paris, France. dratbl@yahoo.fr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Teboul
authors.forename: Alain
authors.initials: A
authors.lastname: Gaffinel
authors.forename: Christophe
authors.initials: C
authors.lastname: Meune
authors.forename: Agnès
authors.initials: A
authors.lastname: Greffet
authors.forename: Patrick
authors.initials: P
authors.lastname: Sauval
authors.forename: Pierre
authors.initials: P
authors.lastname: Carli
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D004417:Dyspnea / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D004632:Emergency Medical Services; D005240:Feasibility Studies; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D012120:Respiration Disorders / Q000150:complications / Q000175:diagnosis
chemical_list: D020097:Natriuretic Peptide, Brain