title: Relationship between body mass index and anti-hypertensive efficacy of doxazosin according to a survey of Japanese patients.
abstract: In this cross-sectional study, we surveyed a population of 101 hypertensive patients in Japan to determine the efficacy of the blood pressure lowering effect of alpha 1-blockers in relation to their body mass index (BMI). We found that doxazosin was frequently administered to obese hypertensive patients; many patients treated with doxazosin were taking concomitant medication. We also demonstrated that the higher the dose of doxazosin, the lower the ambulatory blood pressure measured in the out-patient clinic. Doxazosin showed a more favourable blood pressure lowering effect in patients with a higher BMI. These results suggest that anti-hypertensive drugs are useful when used in obese patients receiving multiple concomitant medications. These patients would normally be considered to show a poor response to anti-hypertensive treatment. Furthermore, we expect the alpha 1-blocker doxazosin to demonstrate a dose-dependent effect in obese patients with hypertension.
authors.affiliation: Cardiovascular Department, Kagawaken Saiseikai Hospital, Takamatsu, Japan. cbx38320@pop16.odn.ne.jp
authors.forename: S
authors.initials: S
authors.lastname: Toyonaga
authors.forename: T
authors.initials: T
authors.lastname: Nakatsu
authors.forename: C
authors.initials: C
authors.lastname: Suezawa
authors.forename: H
authors.initials: H
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Sogou
authors.forename: S
authors.initials: S
authors.lastname: Kusachi
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D017292:Doxazosin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007564:Japan; D008297:Male; D011795:Surveys and Questionnaires
chemical_list: D000959:Antihypertensive Agents; D017292:Doxazosin