title: Zn-alkynylide additions to acyl iminiums.
abstract: [reaction: see text] A new addition reaction of zinc-alkynylides to N-acyl and N-phosphinoyl iminiums is reported. These can be prepared in situ from imines with acid halides in the presence of a Zn-acetylide. The reaction is general with regard to imine, alkyne, and acid halides, allowing access to a large number of differentially protected propargylic amines.
authors.affiliation: Laboratorium für Organische Chemie, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Fischer
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira