The role of endogenous and exogenous DNA damage and mutagenesis.
The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation.
Friedberg
Errol C
EC
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9072, USA. errol.friedberg@utsouthwestern.edu
McDaniel
Lisa D
LD
Schultz
Roger A
RA
D001430:Bacteriocins / Q000235:genetics; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D005199:Fanconi Anemia / Q000235:genetics; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D016296:Mutagenesis / Q000235:genetics* / Q000502:physiology; D009369:Neoplasms / Q000235:genetics*; D051135:Rad51 Recombinase
D001430:Bacteriocins; D004268:DNA-Binding Proteins; C116792:brochocin C; C495153:RAD51 protein, human; D051135:Rad51 Recombinase; D004259:DNA-Directed DNA Polymerase