[Sequence polymorphisms of the mitochondrial DNA control region in 100 Chengdu Hans in China].
OBJECTIVE
To study the genetic polymorphisms of the mitochondrial DNA (mtDNA) control region in Chengdu Han population.


METHODS
Sequence polymorphisms of the mtDNA control region, hypervariable regions I and II from 100 unrelated Chinese Hans were determined by PCR and direct sequencing.


RESULTS
Sequences of 404 nucleotides for hypervariable region I and 379 nucleotides for region II were obtained. Ninety-two and fifty variable sites were revealed in region I and region II respectively as compared to the reference sequence, and a total of 97 different genetic patterns from both the regions I and II were determined. The probability of identity was estimated at 1.84% for region I, 1.94% for region II, and 1.18% for both the regions.


CONCLUSIONS
These results suggest that sequence polymorphism of mtDNA control region would be very useful in forensic practice as a marker for individual identification.
Liang
Wei-bo
WB
College of Basic Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 PR China.
Lu
Mei-li
ML
Jia
Yi
Y
Zhou
Bin
B
Liu
Kuan-lin
KL
Chen
Jing-hui
JH
Liao
Miao
M
Wu
Mei-yun
MY
Zhang
Lin
L
D001483:Base Sequence; D002681:China; D004272:DNA, Mitochondrial / Q000737:chemistry*; D005828:Genetics, Population; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D011110:Polymorphism, Genetic
D004272:DNA, Mitochondrial