Reepithelialization of a full-thickness burn from stem cells of hair follicles micrografted into a tissue-engineered dermal template (Integra).
We report a head and neck full-thickness burn injury that was reconstructed with a tissue-engineered dermal template and then early implantation of microdissected hair follicles through the silicone epidermis 12 days after the burn injury. The treatment resulted in complete reepithelialization and a hair-bearing scalp without the need for a split-thickness skin graft. Restoration of the stem cell population, hair growth, and earlier reepithelialization were achieved using this novel micrografting technique, and histologic examination confirmed maturation of a normal skin type over the subsequent 2 years.
Navsaria
Harshad A
HA
Centre for Cutaneous Research, Bart's and London School of Medicine and Dentistry, Queen Mary, University of London, United Kingdom. h.navsaria@qmul.ac.uk
Ojeh
Nkemcho O
NO
Moiemen
Naiem
N
Griffiths
Matthew A
MA
Frame
James D
JD
D000328:Adult; D001672:Biocompatible Materials; D002056:Burns / Q000601:surgery*; D002809:Chondroitin Sulfates; D003094:Collagen; D004848:Epithelium / Q000502:physiology; D018859:Hair Follicle / Q000166:cytology*; D006801:Humans; D008297:Male; D008866:Microsurgery; D012535:Scalp / Q000293:injuries* / Q000601:surgery*; D017768:Skin, Artificial; D033581:Stem Cell Transplantation; D023822:Tissue Engineering
D001672:Biocompatible Materials; C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen