Rugulotrosins A and B: Two new antibacterial metabolites from an Australian isolate of a Penicillium sp.
Two new antibacterial agents, rugulotrosin A (1) and B (2), were obtained from cultures of a Penicillium sp. isolated from soil samples acquired near Sussex Inlet, New South Wales, Australia. Rugulotrosin A (1) is a chiral symmetric dimer, and its relative stereostructure was determined by spectroscopic and X-ray crystallographic analysis. Rugulotrosin B (2) is a chiral asymmetric dimer isomeric with 1. Its structure was determined by spectroscopic analysis with comparison to the co-metabolite 1 and previously reported fungal metabolites. Both rugulotrosins A and B displayed significant antibacterial activity against Bacillus subtilis, while rugulotrosin A was also strongly active against Enterococcus faecalis and B. cereus.
Stewart
Michael
M
Centre for Molecular Biodiversity, Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland 4072, Australia.
Capon
Robert J
RJ
White
Jonathan M
JM
Lacey
Ernest
E
Tennant
Shaun
S
Gill
Jennifer H
JH
Shaddock
Martin P
MP
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D001409:Bacillus cereus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D018360:Crystallography, X-Ray; D013293:Enterococcus faecalis / Q000187:drug effects; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C486291:rugulotrosin A