Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders.
Several lines of evidence suggest that genetic factors might contribute to the pathogenesis of eating disorders and that brain-derived neurotrophic factor (BDNF) plays a role in the pathophysiology of eating disorders. To investigate the role of the BDNF gene in the susceptibility to eating disorders, we analyzed the BDNF 196G/A gene polymorphism in female patients with eating disorders and female normal controls. The difference in the genotype frequency between patients (n = 198) and normal controls (n = 222) was statistically significant (P = 0.029). Interestingly, a significant (P = 0.015) difference in the genotype frequency between normal controls and bulimia nervosa patients (n = 101) with binge-purging type was detected. This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders.
Koizumi
Hiroki
H
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan.
Hashimoto
Kenji
K
Itoh
Kanako
K
Nakazato
Michiko
M
Shimizu
Eiji
E
Ohgake
Shintaro
S
Koike
Kaori
K
Okamura
Naoe
N
Matsushita
Sachio
S
Suzuki
Kenji
K
Murayama
Masanobu
M
Higuchi
Susumu
S
Iyo
Masaomi
M
D000293:Adolescent; D000328:Adult; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D004247:DNA / Q000032:analysis / Q000235:genetics; D001068:Feeding and Eating Disorders / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
D019208:Brain-Derived Neurotrophic Factor; D004247:DNA