Gene-gene interactions between glutathione-s transferase M1 and matrix metalloproteinase 9 in the formation of hereditary predisposition to chronic obstructive pulmonary disease.
The incidence of allele variants of glutathione-S transferase M1 xenobiotic detoxification gene and matrix metalloproteinase 9 gene was analyzed in patients with chronic obstructive pulmonary disease. A strict gene-gene interaction between these two genes in the formation of hereditary predisposition to this disease was first demonstrated. The combination of glutathione-S transferase M1 genotype 0/0 and matrix metalloproteinase 9 mutant allele (-15621) is a risk factor for chronic obstructive pulmonary disease (OR-7.7).
Yanchina
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ED
Department of Molecular Genetic Technologies, Research Center, St. Petersburg I. P. Pavlov State Medical University, St. Petersburg. dr-lena@mail.ru
Ivchik
T V
TV
Shvarts
E I
EI
Kokosov
A N
AN
Khodzhayantz
N E
NE
D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
D005982:Glutathione Transferase; D020780:Matrix Metalloproteinase 9