Hepcidin and its role in iron absorption.
Maintaining the correct iron balance is crucial to good health. Disorders of iron homeostasis have a global distribution. As iron is not actively excreted by the body, understanding the role of proteins involved in regulating iron uptake is essential to our understanding of disease involving iron homeostasis. Over the past 10 years, major advances have been made in understanding the genetics of iron metabolism and this has led to identification of a number of new proteins, including hepcidin, involved in iron homeostasis.
Robson
K J
KJ
Weatherall Institute of Molecular Medicine, MRC Molecular Haematology Unit, John Radcliffe Hospital, Oxford, OX3 9DS, UK. kathryn.robson@molecular-medicine.oxford.ac.uk
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology*; D006432:Hemochromatosis / Q000378:metabolism; D064451:Hepcidins; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D007501:Iron / Q000378:metabolism*; D051379:Mice
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; C579599:Hamp protein, mouse; D064451:Hepcidins; D007501:Iron