title: [Myocardial infarction as an initial symptom of antiphospholipid syndrome, factor V Leiden mutation, and hyperhomocysteinemia].
abstract: We present a case of a 32-year-old male survivor of two myocardial infarctions, without any classic risk factor of atherosclerosis. Laboratory and genetic diagnostic tests revealed primary antiphospholipid syndrome, mutation in blood coagulation factor V (Leiden) and mild hyperhomocysteinemia, which could be predisposing factors for coronary artery occlusions and should especially be considered in a young patient without apparent cardiovascular risk factors. Additional anticoagulation and substitutional treatment of the folic acid, vitamin B6 and B12 are effective and the continues to do well at home 3 years after discharge.
authors.affiliation: II Katedra Chorób Wewnetrznych CM UJ w Krakowie. j.dropinski@chello.pl
authors.forename: Jerzy
authors.initials: J
authors.lastname: Dropiński
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wegrzyn
authors.forename: Wojciech
authors.initials: W
authors.lastname: Szczeklik
authors.forename: Marek
authors.initials: M
authors.lastname: Krzanowski
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D005165:Factor V / Q000235:genetics*; D005492:Folic Acid / Q000008:administration & dosage; D006397:Hematinics / Q000008:administration & dosage; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D017354:Point Mutation; D013997:Time Factors; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000008:administration & dosage; D025101:Vitamin B 6 / Q000008:administration & dosage
chemical_list: D006397:Hematinics; D025101:Vitamin B 6; D005165:Factor V; D005492:Folic Acid; D014805:Vitamin B 12