title: Potent small molecule CCR1 antagonists.
abstract: The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
authors.affiliation: Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. john_c_kath@groton.pfizer.com
authors.forename: John C
authors.initials: JC
authors.lastname: Kath
authors.forename: William H
authors.initials: WH
authors.lastname: Brissette
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Brown
authors.forename: Maryrose
authors.initials: M
authors.lastname: Conklyn
authors.forename: Amy P
authors.initials: AP
authors.lastname: DiRico
authors.forename: Peter
authors.initials: P
authors.lastname: Dorff
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Gladue
authors.forename: Brett M
authors.initials: BM
authors.lastname: Lillie
authors.forename: Paul D
authors.initials: PD
authors.lastname: Lira
authors.forename: Erin N
authors.initials: EN
authors.lastname: Mairs
authors.forename: William H
authors.initials: WH
authors.lastname: Martin
authors.forename: Eric B
authors.initials: EB
authors.lastname: McElroy
authors.forename: Molly A
authors.initials: MA
authors.lastname: McGlynn
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Paradis
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Poss
authors.forename: Ingrid A
authors.initials: IA
authors.lastname: Stock
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Tylaska
authors.forename: Deye
authors.initials: D
authors.lastname: Zheng
mesh_terms: D002460:Cell Line; D006801:Humans; D054389:Receptors, CCR1; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: C515300:CCR1 protein, human; D054389:Receptors, CCR1; D019707:Receptors, Chemokine