title: BetaCCM enhances retrieval of serial contextual but not of serial spatial memory in mice.
abstract: The effects of inverse agonists of the gamma-aminobutyric acid (GABA)/benzodiazepine receptors such as beta-carboline-3-carboxylate (betaCCM) on retrieval processes have not been studied extensively. This study investigates the effects in mice of an acute betaCCM injection on retrieval of previously acquired serial discriminations, involving distinct contextual cues (Contextual Serial Discrimination, CSD) or identical cues (Serial Spatial Discrimination, SSD) in a four-hole board. Animals submitted to CSD were also evaluated for emotional reactivity in an elevated-plus maze. In both the CSD and the SSD tasks, mice were injected with saline before the learning session began. Twenty-four hours later, mice were replaced on the hole-board following a single dose of saline or betaCCM (0.5 mg/kg or 1.5 mg/kg) injected 20 min before testing. The highest dose of betaCCM improved performance of the first discrimination in the contextual task but not in the spatial task. Moreover, the higher dose of betaCCM produced anxiety-like reactivity in an elevated-plus maze, and scores of 'anxiety' were positively correlated with memory scores. Overall, the data show that the betaCCM enhancement of memory processes depends on: (1) the cues associated with the to-be-remembered information; and (2) the emotional effects of the drug.
authors.affiliation: Laboratoire Plasticité Cérébrale, Université Montpellier II, Montpellier cédex, France.
authors.forename: A
authors.initials: A
authors.lastname: Celerier
authors.forename: C
authors.initials: C
authors.lastname: Pierard
authors.forename: D
authors.initials: D
authors.lastname: Beracochea
mesh_terms: D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D003463:Cues; D004192:Discrimination, Psychological / Q000187:drug effects*; D004644:Emotions / Q000187:drug effects; D058785:GABA-A Receptor Agonists; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
chemical_list: D002243:Carbolines; D058785:GABA-A Receptor Agonists; C036150:beta-carboline-3-carboxylic acid methyl ester