title: Mitral repair is superior to replacement when associated with coronary artery disease.
abstract: OBJECTIVE
  To compare the outcomes of mitral repair and replacement in revascularized patients with ischemic mitral regurgitation.
  
  
  BACKGROUND
  Combined coronary bypass (CABG) and mitral procedures have been associated with the highest mortality (>10%) in cardiac surgery. Recent studies have suggested that mitral valve replacement (MVR) with sparing of the subvalvular apparatus had comparable results to mitral repair when associated with CABG.
  
  
  METHODS
  Over the past 7 years, 54 patients had CABG/mitral repair versus 56 who had CABG/MVR with preservation of the subvalvular apparatus. The groups were similar in age at 69.2 years in the replacement group versus 67.0 in the repair group. We compared these 2 groups based on hospital mortality, incidence of complications including nosocomial infection, neurologic decompensation (stroke), pulmonary complication (pneumonia, atelectasis, and prolonged ventilation), and renal complications (acute renal failure or insufficiency).
  
  
  RESULTS
  The mitral repair group had a hospital mortality of 1.9% versus 10.7% in the replacement group (P = 0.05). Infection occurred in 9% of repairs compared with 13% of replacements (P = 0.59). The incidence of stroke was no different between groups (2 of 54 repairs vs. 2 of 56 replacements, P = 1.00). Pulmonary complication rate was 39% in repairs versus 32% in replacements (P = 0.59). Worsening renal function occurred in 15% of repairs versus 18% of replacements (P = 0.67).
  
  
  CONCLUSIONS
  Mitral repair is superior to mitral replacement when associated with coronary artery disease in terms of perioperative morbidity and hospital mortality. Although preservation of the subvalvular apparatus with MVR has a theoretical advantage in terms of ventricular function, mitral repair clearly adds a survival benefit in patients with concomitant ischemic cardiac disease.
authors.affiliation: Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, MR$ Building, Room 3116, Charlottesville, VA 22908, USA. tbr5q@virginia.edu
authors.forename: T Brett
authors.initials: TB
authors.lastname: Reece
authors.forename: Curtis G
authors.initials: CG
authors.lastname: Tribble
authors.forename: Peter I
authors.initials: PI
authors.lastname: Ellman
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Maxey
authors.forename: Randall L
authors.initials: RL
authors.lastname: Woodford
authors.forename: George M
authors.initials: GM
authors.lastname: Dimeling
authors.forename: Harry A
authors.initials: HA
authors.lastname: Wellons
authors.forename: Ivan K
authors.initials: IK
authors.lastname: Crosby
authors.forename: John A
authors.initials: JA
authors.lastname: Kern
authors.forename: Irving L
authors.initials: IL
authors.lastname: Kron
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000453:epidemiology*; D005260:Female; D006349:Heart Valve Diseases / Q000453:epidemiology* / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome