HERV-K(HML-2) GAG/ENV antibodies as indicator for therapy effect in patients with germ cell tumors.
Germ cell tumors (GCT) are strictly associated with the expression of HERV-K(HML-2) proviruses, and the majority of GCT patients produce antibodies to structural proteins of these proviruses. The objective of our study was to determine the significance of the serological response to HERV-K(HML-2) Gag and Env proteins for diagnosis, management of GCT patients and estimation of the therapy success. The data document a strong association of HERV-K(HML-2) antibodies and the clinical manifestation of the disease and therapy success. HERV-K(HML-2) antibodies seem to have an important diagnostic value as well as indicator of chemotherapy success.
Kleiman
Anna
A
N.N. Blokhin Cancer Research Center, Russian Academy of Medical Science, Moscow, Russia.
Senyuta
Natalia
N
Tryakin
Alexey
A
Sauter
Marlies
M
Karseladze
Apollon
A
Tjulandin
Sergei
S
Gurtsevitch
Vladimir
V
Mueller-Lantzsch
Nikolaus
N
D000906:Antibodies / Q000737:chemistry*; D000914:Antibodies, Viral; D015153:Blotting, Western; D018450:Disease Progression; D020077:Endogenous Retroviruses / Q000235:genetics*; D015686:Gene Products, env / Q000276:immunology*; D015683:Gene Products, gag / Q000276:immunology*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D009362:Neoplasm Metastasis; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics / Q000276:immunology*; D011533:Proviruses / Q000235:genetics; D013997:Time Factors; D014764:Viral Proteins / Q000235:genetics*
D000906:Antibodies; D000914:Antibodies, Viral; D015686:Gene Products, env; D015683:Gene Products, gag; C406149:HERV-K cORF protein, Human endogenous retrovirus K; D014764:Viral Proteins