title: [Lymphoid structure of the spleen in rats exposed to acute emotional stress].
abstract: The objects of this investigation were the sections of the spleen and peripheral blood smears of 40 male Wistar rats of control and experimental groups that were stained using histological and histochemical methods. The rats of experimental groups were killed by decapitation immediately after discontinuation of an emotional stress (exposure to a combination of immobilization and electric skin stimulation for one hour). The changes of cellular composition and cytoarchitectonics of different functional zones of the spleen were estimated. It was found that following the emotional stress the number of small lymphocytes in the periarterial lymphoid sheath (PALS) decreased as compared to that one in control groups. At the same time, the amount of cells in PALS with the signs of destruction increased (from single cells in the animals of control groups to 7.7 and 1.5% in rats of the experimental groups that were predisposed or resistant to stress, respectively). The proportion of T-lymphocytes per PALS unit area in the spleen of experimental rats, predisposed or resistant to stress, decreased 1.6 and 1.2 times, respectively, in comparison to the control groups.
authors.affiliation: Department of Human Anatomy, I.M. Sechenov Moscow Medical Academy.
authors.forename: A A
authors.initials: AA
authors.lastname: Bakhmet
mesh_terms: D000208:Acute Disease; D000818:Animals; D004558:Electric Stimulation; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013315:Stress, Psychological / Q000097:blood / Q000276:immunology*