title: Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia.
abstract: Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progenitor growth.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Giribaldi
authors.forename: Daniela
authors.initials: D
authors.lastname: Ulliers
authors.forename: Evelin
authors.initials: E
authors.lastname: Schwarzer
authors.forename: Irene
authors.initials: I
authors.lastname: Roberts
authors.forename: Wanda
authors.initials: W
authors.lastname: Piacibello
authors.forename: Paolo
authors.initials: P
authors.lastname: Arese
mesh_terms: D000447:Aldehydes / Q000494:pharmacology*; D000740:Anemia / Q000209:etiology*; D000818:Animals; D002478:Cells, Cultured; D004920:Erythropoiesis / Q000187:drug effects*; D006420:Hemeproteins / Q000494:pharmacology*; D006801:Humans; D008288:Malaria / Q000097:blood*; D010961:Plasmodium / Q000737:chemistry / Q000472:pathogenicity
chemical_list: D000447:Aldehydes; D006420:Hemeproteins; C020753:hemozoin; C027576:4-hydroxy-2-nonenal