Effect of co-administration of lithium and reboxetine on extracellular monoamine concentrations in rats.
We investigated the effect of reboxetine, a selective noradrenaline reuptake inhibitor, 7 days after treatment with subchronic lithium on extracellular noradrenaline, dopamine and serotonin (5-HT) concentrations in the medial prefrontal cortex. Acute treatment with reboxetine significantly increased extracellular concentrations of noradrenaline and dopamine, but did not alter 5-HT concentrations. Subchronic lithium increased basal levels of extracellular 5-HT, but not noradrenaline or dopamine. Co-administration of reboxetine and lithium treatment increased the extracellular concentrations of noradrenaline, dopamine and 5-HT, though reboxetine alone increased the extracellular levels of noradrenaline and dopamine only. Thus, combined lithium and reboxetine produces an additive effect neurochemically rather than their interaction.
Kitaichi
Yuji
Y
Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita, Sapporo 060-8638, Japan. ykita@med.hokudai.ac.jp
Inoue
Takeshi
T
Nakagawa
Shin
S
Izumi
Takeshi
T
Koyama
Tsukasa
T
D000284:Administration, Oral; D000818:Animals; D004298:Dopamine / Q000737:chemistry / Q000378:metabolism; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005110:Extracellular Space / Q000737:chemistry* / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D016651:Lithium Carbonate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009638:Norepinephrine / Q000737:chemistry / Q000378:metabolism; D017397:Prefrontal Cortex / Q000737:chemistry / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077593:Reboxetine; D012701:Serotonin / Q000737:chemistry / Q000378:metabolism
D009025:Morpholines; D016651:Lithium Carbonate; D012701:Serotonin; D000077593:Reboxetine; D004298:Dopamine; D009638:Norepinephrine