Cyclic peptide alkaloids from the bark of Discaria americana.
The isolation and structure determination of cyclic peptide alkaloids, discarine-M and discarine-N, along with seven known cyclic peptide alkaloids, adouetine-Y', franganine, frangulanine, discarines-A, -B, -C, and -D from the root bark of Discaria americana are described. Structures were determined spectroscopically, especially using 2D NMR spectroscopic analysis. The crude methanol extract, the basic ether extract, and the alkaloids 6 and 7 also weakly inhibited growth of gram-negative and gram-positive bacteria.
Giacomelli
Sandro R
SR
Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria RS, Brazil.
Maldaner
Graciela
G
Gonzaga
Wellington A
WA
Garcia
Claudia M
CM
da Silva
Ubiratan F
UF
Dalcol
Ionara I
II
Morel
Ademir F
AF
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D007711:Klebsiella pneumoniae / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D027823:Rhamnaceae / Q000737:chemistry*; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
D000470:Alkaloids; D010456:Peptides, Cyclic; D010936:Plant Extracts