20-Hydroxyeicosatetraenoic acid potentiates contractile activation of canine basilar artery in response to stretch via protein kinase Calpha-mediated inhibition of calcium-activated potassium channel.
Nakayama
Koichi
K
Department of Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan. nakyamk@ys7.u-shizuoka-ken.ac.jp
Obara
Kazuo
K
Tanabe
Yoshiyuki
Y
Ishikawa
Tomohisa
T
D000818:Animals; D001488:Basilar Artery / Q000737:chemistry*; D004285:Dogs; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology*; D008564:Membrane Potentials; D009119:Muscle Contraction / Q000187:drug effects*; D009281:Naphthalenes / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology; D011188:Potassium / Q000737:chemistry; D024681:Potassium Channels, Calcium-Activated / Q000737:chemistry*; D020033:Protein Isoforms; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051571:Protein Kinase C-alpha; D013997:Time Factors; D014118:Toxins, Biological / Q000494:pharmacology
D006893:Hydroxyeicosatetraenoic Acids; D009281:Naphthalenes; D010455:Peptides; D024681:Potassium Channels, Calcium-Activated; D020033:Protein Isoforms; D014118:Toxins, Biological; C064719:iberiotoxin; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid; D011493:Protein Kinase C; D051571:Protein Kinase C-alpha; C058819:calphostin C; D011188:Potassium