Protective effect of Astragalus corniculatus saponins against myeloid graffi tumour in hamsters.
A purified mixture containing mostly saponins (PMS) from Astragalus corniculatus Bieb. was used in an in vivo model to demonstrate its protective effect against myeloid Graffi tumour in hamsters. Survivability, tumour growth and tumour transplantability were followed. Comparative studies revealed that the intraperitoneal administration of PMS: (i) decreased the tumour transplantability; (ii) inhibited tumour growth in the early stages of tumour progression; (iii) increased the mean survival time; (iv) reduced the percentage mortality. These results suggest that appropriate use of PMS could outline a promising strategy for the treatment of myeloid Graffi tumour.
Krasteva
I N
IN
Department of Pharmacognosy, Faculty of Pharmacy, Medical University, 2 Dunav St., 1000 Sofia, Bulgaria.
Toshkova
R A
RA
Nikolov
S D
SD
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D027883:Astragalus Plant; D045744:Cell Line, Tumor / Q000187:drug effects*; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009101:Multiple Myeloma / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000517:prevention & control; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D010936:Plant Extracts; D012503:Saponins