title: Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil.
abstract: This study analysed and compared the effects of chronic oral treatment with quercetin or verapamil on systolic blood pressure and vascular function in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Quercetin and verapamil inhibited the development of DOCA-salt-induced hypertension in a similar manner. DOCA-salt-hypertensive rats showed potassium depletion and oxidative stress, prevented only by concomitant quercetin administration. Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats. In conclusion, quercetin and verapamil show similar antihypertensive effects in mineralocorticoid hypertension, but quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation, suggesting a better vascular protection in this volume expansion hypertension model.
authors.affiliation: Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.
authors.forename: Milagros
authors.initials: M
authors.lastname: Galisteo
authors.forename: María Francisca
authors.initials: MF
authors.lastname: García-Saura
authors.forename: Rosario
authors.initials: R
authors.lastname: Jiménez
authors.forename: Inmaculada Concepción
authors.initials: IC
authors.lastname: Villar
authors.forename: Rosemary
authors.initials: R
authors.lastname: Wangensteen
authors.forename: Antonio
authors.initials: A
authors.lastname: Zarzuelo
authors.forename: Félix
authors.initials: F
authors.lastname: Vargas
authors.forename: Juan
authors.initials: J
authors.lastname: Duarte
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D008517:Phytotherapy; D010946:Plants, Medicinal; D011189:Potassium Chloride; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D011189:Potassium Chloride; D011794:Quercetin; D014700:Verapamil