title: Antimicrobial activities of N-(2-hydroxy-1-naphthalidene)-amino acid(glycine, alanine, phenylalanine, histidine, tryptophane) Schiff bases and their manganese(III) complexes.
abstract: The in vitro antibacterial and antifungal activities of five different amino acid Schiff bases derived from the reaction of 2-hydroxy-1-naphthaldehyde with glycine, L-alanine L-phenylalanine, L-histidine, L-tryptophane and the manganese(III) complexes of these bases were investigated. Structures of the Schiff bases were proven by 1H-NMR. In vitro activities against some Gram-positive (Staphylococcus aureus and Bacillus polymyxa) and Gram-negative (Escherichia coli) bacteria and the fungus Candida albicans were determined. The antimicrobial activities tended to decrease with the increasing size of the amino acid residues.
authors.affiliation: Ankara University, Science Faculty, Department of Chemistry, 06100 Tandogan, Ankara, Turkey.
authors.forename: Iffet
authors.initials: I
authors.lastname: Sakiyan
authors.forename: Elif
authors.initials: E
authors.lastname: Loğoğlu
authors.forename: Seza
authors.initials: S
authors.lastname: Arslan
authors.forename: Nurşen
authors.initials: N
authors.lastname: Sari
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Sakiyan
mesh_terms: D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000378:metabolism / Q000494:pharmacology*; D012545:Schiff Bases / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D008345:Manganese