[Serum concentration and antiviral activity of interferon alpha in chronic hepatitis and liver cirrhosis].
Blood serum concentration and antiviral activity of IFN-alpha were studied in 121 patients with chronic hepatitis (CH) and in 115 patients with hepatocirrhosis (HC). The increase in IFN-alpha antiviral activity was revealed in 62% CH patients and in 46% HC patients. In CH patients both the mean indices of blood serum IFN-alpha concentration and its antiviral activity increased. The changes were more expressed in CH having viral etiology (HBV and HCV). For the most CH patients with disease positive dynamics the initially high indices of IFN-alpha antiviral activity were typical. In HC patients with portal hypertension syndrome progress and against the background of increased blood serum IFN-alpha concentration its antiviral activity decreases. With development hepatocellular insufficiency, increasing of disease stage (according to the Child-Pugh classification) the decrease in IFN-alpha concentration and its antiviral activity is noted.
Levitan
B N
BN
Astakhin
A V
AV
Chishieva
E M
EM
Afanas'ev
S S
SS
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000097:blood* / Q000494:pharmacology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood* / Q000276:immunology / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000097:blood* / Q000276:immunology / Q000821:virology; D006801:Humans; D016898:Interferon-alpha / Q000097:blood* / Q000494:pharmacology; D008103:Liver Cirrhosis / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D000998:Antiviral Agents; D016898:Interferon-alpha