Association of anterior glottic webs with velocardiofacial syndrome (chromosome 22q11.2 deletion).
OBJECTIVE
An association between anterior glottic webs and velocardiofacial syndrome (chromosome 22q11.2 deletion) has previously been noted in a number of case reports. Our objective was to determine if the presence of such webs warrants a high index of suspicion for this chromosome deletion. Study design and setting This study was carried out in the Division of Pediatric Otolaryngology-Head and Neck Surgery at Cincinnati Children's Hospital Medical Center. Chromosome 22q11.2 deletion status was determined for all patients endoscopically diagnosed with anterior glottic webs between July 1998 and December 2000. Families of patients who tested positive for the deletion were referred to the Cincinnati Children's Division of Human Genetics for additional evaluation and counseling.


RESULTS
Eleven of 17 patients (65%) with anterior glottic webs were positive for chromosome 22q11.2 deletion. Of these 11 patients, 5 showed subtle clinical manifestations of velocardiofacial syndrome and underwent genetic testing due only to the presence of a web. All 11 patients were diagnosed with velocardiofacial syndrome.


CONCLUSIONS
We strongly recommend that all patients diagnosed with anterior glottic webs undergo fluorescence in situ hybridization evaluation for this chromosome deletion.
Miyamoto
R Christopher
RC
Division of Pediatric of Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Cotton
Robin T
RT
Rope
Alan F
AF
Hopkin
Robert J
RJ
Cohen
Aliza P
AP
Shott
Sally R
SR
Rutter
Michael J
MJ
D002648:Child; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D005931:Glottis / Q000002:abnormalities; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007830:Larynx / Q000002:abnormalities*; D011446:Prospective Studies; D014681:Velopharyngeal Insufficiency / Q000235:genetics*