[Effect of a postsynaptic alpha2-adrenoreceptor antagonist beditin on the rat resistance to seizure and Ca(+)-level in the brain tissue].
In rats with a hemodynamic disorder caused by acute myocardial ischemia, preliminary administration of beditin in a dose of 25 mg/kg fully prevents a manifold increase in the level of 45Ca2+ in the cytosol of brain cells and leads to enhanced trapping and accumulation of labeled calcium in endoplasmic reticulum. With respect to calcium binding in endoplasmic reticulum, the action of beditin substantially differs from that of verapamil.
Shirinian
E A
EA
Laboratory of Pharmacology of Cardiovascular Drugs, Institute of Fine Organic Chemistry, National Academy of Sciences of the Republic of Armenia, Azatutyan pr. 26, Yerevan, 375014 Armenia.
Arutiunian
S A
SA
Petrosian
A A
AA
Gevorkian
G A
GA
Markarian
E A
EA
Vartanian
S O
SO
Medvedev
O S
OS
Garibdzhanian
B T
BT
D058669:Adrenergic alpha-2 Receptor Antagonists; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004146:Dioxanes / Q000627:therapeutic use*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D051379:Mice; D051381:Rats; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013045:Species Specificity; D013844:Thiazoles / Q000627:therapeutic use*
D058669:Adrenergic alpha-2 Receptor Antagonists; D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D004146:Dioxanes; D013844:Thiazoles; C107649:beditine; D002118:Calcium