Increased coagulation factor levels leading to allograft renal vein thrombosis.
A patient with end-stage kidney disease is described, who lost his renal allograft in the early post-transplant period due to allograft renal vein thrombosis. Prior to transplantation, he had been treated by hemodialysis and lost several vascular accesses because of thrombosis. A search for potential thrombophilic factors disclosed a unique combination of increased clotting factor levels, i.e. FVIII, FIX, FXI and homocysteine. More common hereditary and acquired hypercoagulability factors have been excluded in this patient. While clotting factor deficiencies are well known causes of hemophilia, their levels should also be measured in the workup of transplant candidates with a history of multiple vascular access thrombosis.
Hausmann
M J
MJ
Department of Nephrology, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University, Beer-Sheva, Israel. hausmann@bgumail.bgu.ac.il
Vorobiov
M
M
Zlotnik
M
M
Rogachev
B
B
Tomer
A
A
D001779:Blood Coagulation Factors / Q000378:metabolism*; D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005172:Factor XI / Q000032:analysis; D006084:Graft Rejection / Q000209:etiology*; D006085:Graft Survival; D006710:Homocysteine / Q000097:blood; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012082:Renal Veins; D020246:Venous Thrombosis / Q000097:blood*
D001779:Blood Coagulation Factors; D006710:Homocysteine; D005167:Factor VII; D005169:Factor VIII; D005164:Factor IX; D005172:Factor XI