title: Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans.
abstract: OBJECTIVE
  To examine the effects of two different conjugated linoleic acid (CLA) isomers at two different intakes on body composition in overweight humans.
  
  
  METHODS
  Eighty-one middle-aged, overweight, healthy men and women participated in this bicentric, placebo-controlled, double-blind, randomized study. For 6 weeks (run-in period), all subjects consumed daily a drinkable dairy product containing 3 g of high oleic acid sunflower oil. Volunteers were then randomized over five groups receiving daily either 3 g of high oleic acid sunflower oil, 1.5 g of cis-9,trans-11 (c9t11) CLA, 3 g of c9t11 CLA, 1.5 g of trans-10,cis-12 (t10c12) CLA, or 3 g of t10c12 CLA administrated as triacylglycerol in a drinkable dairy product for 18 weeks. Percentage body fat mass and fat and lean body mass were assessed at the end of the run-in and experimental periods by DXA. Dietary intake was also recorded.
  
  
  RESULTS
  Body fat mass changes averaged 0.1 +/- 0.9 kg (mean +/- SD) in the placebo group and -0.3 +/- 1.4, -0.8 +/- 2.1, 0.0 +/- 2.3, and -0.9 +/- 1.7 kg in the 1.5-g c9t11, 3-g c9t11, 1.5-g t10c12, and 3-g t10c12 groups, respectively. Changes among the groups were not significantly different (p = 0.444). Also, lean body mass and dietary intake were not significantly different among the treatments.
  
  
  CONCLUSIONS
  A daily consumption of a drinkable dairy product containing up to 3 g of CLA isomers for 18 weeks had no statistically significant effect on body composition in overweight, middle-aged men and women.
authors.affiliation: Unité du Métabolisme Protéino-Energétique, Université d'Auvergne/Institut National de la Recherche Agronomique, Centre de Recherche en Nutrition Humaine Auvergne, Clermont Ferrand, France. corinne.brugere@clermont.inre.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Malpuech-Brugère
authors.forename: Wilhelmine P H G
authors.initials: WP
authors.lastname: Verboeket-van de Venne
authors.forename: Ronald P
authors.initials: RP
authors.lastname: Mensink
authors.forename: Marie-Agnès
authors.initials: MA
authors.lastname: Arnal
authors.forename: Béatrice
authors.initials: B
authors.lastname: Morio
authors.forename: Marion
authors.initials: M
authors.lastname: Brandolini
authors.forename: Asgeir
authors.initials: A
authors.lastname: Saebo
authors.forename: Taous S
authors.initials: TS
authors.lastname: Lassel
authors.forename: Jean Michel
authors.initials: JM
authors.lastname: Chardigny
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Sébédio
authors.forename: Bernard
authors.initials: B
authors.lastname: Beaufrère
mesh_terms: D000273:Adipose Tissue; D000328:Adult; D000368:Aged; D001628:Beverages; D001823:Body Composition / Q000187:drug effects*; D015992:Body Mass Index; D001835:Body Weight; D003611:Dairy Products; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000008:administration & dosage; D010919:Placebos; D010938:Plant Oils / Q000008:administration & dosage; D000074242:Sunflower Oil; D014280:Triglycerides / Q000008:administration & dosage
chemical_list: D004042:Dietary Fats, Unsaturated; D044243:Linoleic Acids, Conjugated; D010919:Placebos; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D019301:Oleic Acid