Molecular basis for the chloride channel activity of cystic fibrosis transmembrane conductance regulator and the consequences of disease-causing mutations.
Kidd
Jackie F
JF
Programme in Structural Biology and Biochemistry Research Institute, Hospital for Sick Children, Department of Physiology, University of Toronto, Toronto Canada M5G 1X8.
Kogan
Ilana
I
Bear
Christine E
CE
D000595:Amino Acid Sequence; D018118:Chloride Channels / Q000737:chemistry* / Q000502:physiology; D002713:Chlorine / Q000737:chemistry; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D004064:Digestive System / Q000378:metabolism; D004594:Electrophysiology; D006868:Hydrolysis; D007473:Ion Channels / Q000502:physiology; D007477:Ions; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D010183:Pancreatic Ducts / Q000502:physiology; D010766:Phosphorylation; D020836:Protein Structure, Quaternary; D017434:Protein Structure, Tertiary; D012137:Respiratory System / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D018118:Chloride Channels; D007473:Ion Channels; D007477:Ions; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D002713:Chlorine