[Use of hypertonic colloid solution in the treatment of heart failure in early postoperative period].
OBJECTIVE
The aim of the study was to estimate the differences in hemodynamic, metabolic and cardiovascular parameters in early postoperative period in hypertonic colloid solution and usual infusion therapy groups.


METHODS
The study was blind placebo controlled. Thirty patients were randomly divided into two groups. The control group received usual Ringer solution for hypovolemia correction and the study group received 250 ml of 7.2% NaCl/6% Hydroxyethylstarch (HyperHaes, Frezenius) solution. The measurements were made before, immediately after the infusion, 60 min and 180 min after infusion. The parameters of central hemodynamics, oxygen transport, the temperature gradient, electrolyte concentration and fluid balance were evaluated.


RESULTS
After infusion of HyperHaes solution cardiac index increased from 2.8+/-0.2 to 3.8+/-0.3 L/min/m(2), pulmonary vascular resistance and systemic vascular resistance decreased. Serum Na(+)and Cl (-)increase in investigative group did not exceeded normal range and returned to initial level after an hour. The total fluid balance and fluid balance during surgery in investigative group was less than that in the control group.


CONCLUSIONS
HyperHaes solution in early postoperative period after coronary artery bypass grafting surgery increased preload, had the tendency of decreasing afterload, increased cardiac index, decreased total fluid balance and did not cause hypernatremia and hyperchloremia.
Sneider
Edvin
E
Institute for Biomedical Research, Kaunas University of Medicine, Clinic of Cardiosurgery, Heart Center, Lithuania. edvins@takas.lt
Bieliūnas
Algimantas
A
Sirvinskas
Edmundas
E
Benetis
Rimantas
R
D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D001026:Coronary Artery Bypass; D004231:Diuresis; D006333:Heart Failure / Q000628:therapy*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D006982:Hypertonic Solutions; D020896:Hypovolemia; D007552:Isotonic Solutions; D008875:Middle Aged; D011184:Postoperative Period; D000077331:Ringer's Solution; D013997:Time Factors; D014655:Vascular Resistance; D014882:Water-Electrolyte Balance
D006895:Hydroxyethyl Starch Derivatives; D006982:Hypertonic Solutions; D007552:Isotonic Solutions; D000077331:Ringer's Solution