title: A historical perspective on RNA editing: how the peculiar and bizarre became mainstream.
abstract: The known examples of RNA editing now encompass a variety of alterations of RNA primary sequence that arise from base modifications, nucleotide insertions or deletions, and nucleotide replacements. Hence, the definition of RNA editing has evolved as new systems have been described. This chapter presents a historical perspective on some of the pivotal discoveries that helped direct the current avenues of research in the field of RNA editing.
authors.affiliation: Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA.
authors.forename: Donna J
authors.initials: DJ
authors.lastname: Koslowsky
mesh_terms: D000818:Animals; D001483:Base Sequence; D056890:Eukaryota / Q000235:genetics; D014644:Genetic Variation; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D017393:RNA Editing / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D016053:RNA, Protozoan / Q000235:genetics
chemical_list: D016053:RNA, Protozoan