title: Anaphylaxis: a 7-year follow-up survey of 46 children.
abstract: BACKGROUND
  Little is known about the frequency of and the features associated with recurrent anaphylaxis in pediatric populations. During 1994 to 1996, we enrolled 76 children affected by anaphylaxis in a prospective study to analyze their clinical and allergic features.
  
  
  OBJECTIVE
  To undertake a follow-up study of these children to ascertain how many experienced a recurrence of anaphylaxis.
  
  
  METHODS
  After a mean interval of 7 years, a pediatric allergist conducted a telephone interview of patients who had been enrolled in our 1994-1996 study.
  
  
  RESULTS
  A telephone interview was successfully completed in 46 (61%) of the 76 patients who had been enrolled in our 1994-1996 study. Of these 46 patients, 14 (30%) had experienced a recurrence of anaphylaxis. Children with atopic dermatitis either during 1994 to 1996 (64% vs 34%; P = .04) or at the time of the current study (43% vs 16%; P = .03) and those with urticaria-angioedema at the time of the current study (93% vs 31%; P = .0002) were found to be at a significantly higher risk for recurrent anaphylaxis. Furthermore, those children who were sensitive to at least 1 food allergen during 1994 to 1996 were more likely to have experienced a recurrence of anaphylaxis (93% vs 56%; P < .04).
  
  
  CONCLUSIONS
  This study suggests that patients may have a greater risk of recurrence of anaphylaxis if they have atopic dermatitis, urticaria-angioedema, or at least 1 positive result of skin prick tests to food allergens.
authors.affiliation: Allergy and Clinical Immunology Unit, III Pediatric Clinic, University of Florence, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Cianferoni
authors.forename: Elio
authors.initials: E
authors.lastname: Novembre
authors.forename: Neri
authors.initials: N
authors.lastname: Pucci
authors.forename: Enrico
authors.initials: E
authors.lastname: Lombardi
authors.forename: Roberto
authors.initials: R
authors.lastname: Bernardini
authors.forename: Alberto
authors.initials: A
authors.lastname: Vierucci
mesh_terms: D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D000707:Anaphylaxis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002669:Child Welfare; D003625:Data Collection; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
chemical_list: D000318:Adrenergic beta-Agonists; D004837:Epinephrine