title: CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
abstract: Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta+ T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha.
authors.affiliation: La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
authors.forename: Loui T
authors.initials: LT
authors.lastname: Madakamutil
authors.forename: Urs
authors.initials: U
authors.lastname: Christen
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lena
authors.forename: Yiran
authors.initials: Y
authors.lastname: Wang-Zhu
authors.forename: Antoine
authors.initials: A
authors.lastname: Attinger
authors.forename: Monisha
authors.initials: M
authors.lastname: Sundarrajan
authors.forename: Wilfried
authors.initials: W
authors.lastname: Ellmeier
authors.forename: Matthias G
authors.initials: MG
authors.lastname: von Herrath
authors.forename: Peter
authors.initials: P
authors.lastname: Jensen
authors.forename: Dan R
authors.initials: DR
authors.lastname: Littman
authors.forename: Hilde
authors.initials: H
authors.lastname: Cheroutre
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001117:Arenaviridae Infections / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D002470:Cell Survival; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D020395:Receptors, Interleukin-7 / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D008562:Membrane Glycoproteins; D020395:Receptors, Interleukin-7; C415350:interleukin-7 receptor, alpha chain; C028388:thymus-leukemia antigens; D007371:Interferon-gamma