[Gender has a strong modulating effect on the risk of Alzheimer's disease conferred by the apolipoprotein E gene in the population of the Canary Islands, Spain].
OBJECTIVE
Apolipoprotein E (ApoE) gen has been found to confer risk for Alzheimer disease in every population studied. We are interested in analyzed the exonic variants and the promoter polymorphisms in our Canary population.


METHODS
By means of PCR RFLP analysis of DNA from patients (NINCS ADRDA criteria) and controls (cognitive state CAMCOG test measured) we analyzed the known exonic and promoter polymorphism of ApoE gen.


RESULTS
We have found an association of Alzheimer disease risk based on exonic variants of ApoE gen, with a clear cut dose effect on susceptibility and no risk conferred by the promoter polymorphisms. Age at onset are not affected by variants of ApoE gen, and patients gender strongly modulate the disease susceptibility.


CONCLUSIONS
We have found in our Canary population an association between Alzheimer disease with exonic variants of ApoE gen with a strong modulation by the patients gender.
Déniz Naranjo
M C
MC
Servico de Immunología, Hospital Dr Negrin de Gran, Las Palmas de Gran Canaria, España.
Muñoz Fernández
C
C
Alemany Rodríguez
M J
MJ
Pérez Viéitez
M C
MC
Irurita Latasa
J
J
Suárez Armas
R
R
Suárez Valentín
M P
MP
Sánchez García
F
F
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001266:Atlantic Islands / Q000453:epidemiology; D005091:Exons / Q000235:genetics; D005260:Female; D018628:Gene Dosage; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011401:Promoter Regions, Genetic / Q000235:genetics; D020033:Protein Isoforms / Q000235:genetics; D012306:Risk; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D020033:Protein Isoforms