Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification.
The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant organs, these internal cells are converted to external cells via an unprecedented cousin-cousin cell-fate respecification event. Conversely, ectopic HAMLET expression in the external cell branch leads to internal cell production. The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner.
Moore
Adrian W
AW
Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, CA 94143, USA.
Roegiers
Fabrice
F
Jan
Lily Y
LY
Jan
Yuh-Nung
YN
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins / Q000378:metabolism; D005260:Female; D008297:Male; D009457:Neuroglia / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009687:Nuclear Proteins / Q000378:metabolism; D051762:PAX2 Transcription Factor; D011984:Sensory Receptor Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C464822:HAM protein, Drosophila; D009687:Nuclear Proteins; D051762:PAX2 Transcription Factor; D014157:Transcription Factors