title: Multiple parotid lymphoepithelial cysts in patients with HIV-infection: report of two cases.
abstract: OBJECTIVE
  Bilateral and multiple lymphoepithelial cysts (LECs) of major salivary glands, in particular of parotid glands, are quite rare and have been reported in human immunodeficiency virus (HIV) infected patients with an incidence of about 3-6%. These lesions represent an early manifestation of HIV infection and are rarely found in patients with advanced acquired immunodeficiency syndrome.
  
  
  METHODS
  Two cases of parotid LECs, the first occurring in a middle-age white woman and the second in a young white boy, both in advanced phases of HIV infection, are reported.
  
  
  RESULTS
  Clinical, cytological, histological and immunohistochemical (cytokeratin AE1/AE3, CD20, CD45RA, CD8, kappa and lambda immunoglobulin light chains, S-100, MLA and Ki67) features are described.
  
  
  CONCLUSIONS
  Fine needle aspiration (FNA), a relatively non-traumatic procedure, could represent both a diagnostic and a therapeutic tool in parotid LECs. No surgical therapy is usually required for these lesions and aspiration of cystic fluid with FNA is quite resolutive, although evidence of further relapses does exist. Surgical excision may become necessary when pain, because of persistent and progressive swelling of the parotid gland, occurs.
authors.affiliation: Department of Dental Sciences and Surgery, University of Bari, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Favia
authors.forename: S
authors.initials: S
authors.lastname: Capodiferro
authors.forename: M
authors.initials: M
authors.lastname: Scivetti
authors.forename: M G
authors.initials: MG
authors.lastname: Lacaita
authors.forename: A
authors.initials: A
authors.lastname: Filosa
authors.forename: L
authors.initials: L
authors.lastname: Lo Muzio
mesh_terms: D000293:Adolescent; D001402:B-Lymphocytes / Q000473:pathology; D001707:Biopsy, Needle; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D020420:Cyst Fluid / Q000737:chemistry; D003560:Cysts / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010305:Parotid Diseases / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
chemical_list: D019394:Ki-67 Antigen; D009418:S100 Proteins; D007633:Keratins