title: Jump-starting the immune system: prime-boosting comes of age.
abstract: A major challenge for immunologists has been the development of vaccines designed to emphasize cellular immune responses. One particularly promising approach is the prime-boost strategy, which has been shown to generate high levels of T-cell memory in animal models. Recently, several papers have highlighted the power of prime-boost strategies in eliciting protective cellular immunity to a variety of pathogens and have demonstrated efficacy in humans. Coupled with recent advances in our understanding of the mechanisms underlying the generation, maintenance and recall of T-cell memory, the field is poised to make tremendous progress. This Review discusses the impact of these recent developments on the future of prime-boost vaccine strategies.
authors.affiliation: Trudeau Institute, 154 Algonquin Ave., Saranac Lake, NY 12983, USA. dwoodland@trudeauinstitute.org
authors.forename: David L
authors.initials: DL
authors.lastname: Woodland
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D018928:Immunity, Mucosal / Q000276:immunology; D007117:Immunization, Secondary / Q000379:methods*; D016056:Immunodominant Epitopes / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D016056:Immunodominant Epitopes; D014612:Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic