title: [Comparative clinical evaluation of the effectiveness of modified radical mastectomy and organ-preserving therapy in localized breast cancer (pT1-2N0M0)].
abstract: The outcome of 320 patients with breast tumors was followed. Modified total mastectomy with subsequent irradiation, chemo- and/or hormone therapy was given to 164 patients. Limb-saving surgery was performed in 156. Incidence of locally advanced recurrences did not differ significantly in the two groups--3.7 and 5.5%, respectively. Nor did 5-year overall (90 +/- 1.4% and 88.4% +/- 1.6%, respectively) and relapse-free survival (88.4 +/- 1.2% and 83.5 +/- 1.4%, respectively) (p < 0.05). Hence, mastectomy is not worth more than sparing treatment.
authors.affiliation: Oncological Dispensary, Leningrad Region.
authors.forename: L D
authors.initials: LD
authors.lastname: Roman
authors.forename: K A
authors.initials: KA
authors.lastname: Fedorov
authors.forename: D A
authors.initials: DA
authors.lastname: Krasnozhon
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D016019:Survival Analysis; D016896:Treatment Outcome