Malaria sporozoite: migrating for a living.
Plasmodium sporozoite invasion of host hepatocytes is an initial key step in infection by malaria parasite. Sporozoites can enter hepatocytes via two distinct pathways: by disruption of the plasma membrane followed by parasite migration through cells, or by the formation of a vacuole essential for further differentiation of the parasite. For Plasmodium falciparum, this differentiation requires the presence of CD81 on the hepatocyte surface. Recent findings with rodent parasites also suggest that migration through cells has an effect on both the sporozoite infectivity and the permissiveness of surrounding cells.
Silvie
Olivier
O
Inserm U511, Immunobiologie Cellulaire et Moléculaire des Infections Parasataires, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France. silvie@ext.jussieu.fr
Franetich
Jean-François
JF
Rénia
Luarent
L
Mazier
Dominique
D
D000220:Adaptation, Biological; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002465:Cell Movement; D022781:Hepatocytes / Q000469:parasitology*; D006801:Humans; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000469:parasitology*; D010961:Plasmodium / Q000254:growth & development / Q000472:pathogenicity*; D034101:Sporozoites / Q000502:physiology; D060225:Tetraspanin 28
D015703:Antigens, CD; C554798:CD81 protein, human; D060225:Tetraspanin 28