Differential electrolytic potentiometric determination of some thiol compounds in their dosage forms.
The application of direct current differential electrolytic potentiometry to an aqueous titration of L-cysteine hydrochloride, captopril and D-penicillamine has been investigated. The basic character of thiol compounds in nitric acid is enhanced to permit their direct titrations with silver nitrate. A pair of silver amalgam electrodes was used as an indicating system. Titration curve shapes obtained are almost symmetrical with sharp peaks. The optimum current density for those titrations was found to be 0.2-2 microA/cm2. The procedure was applied successfully to the determination of certain thiol compounds in drug formulations and the results were favorably compared statistically with those obtained from official methods.
Al-Ghannam
S M
SM
Department of Chemistry, Girls College of Science, P.O. Box 838, Dammam 31113, Saudi Arabia. sm_ghannam@yahoo.com
D004304:Dosage Forms / Q000592:standards; D004572:Electrolysis / Q000592:standards; D011199:Potentiometry / Q000379:methods / Q000592:standards; D013438:Sulfhydryl Compounds / Q000008:administration & dosage* / Q000032:analysis* / Q000592:standards
D004304:Dosage Forms; D013438:Sulfhydryl Compounds