title: Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents.
abstract: Several new spiro indoline-based heterocycles were synthesized by prior preparation of the 4-(2'-oxo-indol-3'-ylidene)-oxazol-5-one derivatives and subsequent reaction of the produced indol-3-ylidene based heterocycles with activated nitrile reagents. The obtained products were allowed to react with hydrazine hydrate in alcoholic basic to give the target compounds. Structure of these products was confirmed on the bases of elemental as well as spectral data. Representative compounds of the hitherto synthesized products were tested and evaluated as antimicrobial agents.
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt. mahanna69@hotmail.com
authors.forename: A H
authors.initials: AH
authors.lastname: Abdel-Rahman
authors.forename: E M
authors.initials: EM
authors.lastname: Keshk
authors.forename: M A
authors.initials: MA
authors.lastname: Hanna
authors.forename: Sh M
authors.initials: ShM
authors.lastname: el-Bady
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared
chemical_list: D000890:Anti-Infective Agents; D006571:Heterocyclic Compounds; D007211:Indoles; C057812:indoline