[Cell therapy for urethral sphincter incompetence by muscle precursor cell autograft].
This article reviews cell therapy for muscle diseases and describes the development of a treatment for urethral sphincter insufficiency by muscle precursor cell (MPC) autograft. These studies were conducted in several successive steps, comprising: 1) comparative study of the cellular mechanisms of regeneration of skeletal striated muscle and urethral striated sphincter and development of a method of extraction of MPC; 2) creation of an animal model of sphincter injury reproducing chronic denervation lesions and fibrosis responsible for sphincter insufficiency in human; 3) study of the biology of intrasphincteric transplantation of MPC extracted from peripheral muscle, taking into account the interactions between these cells and the peripheral nervous system.
Yiou
René
R
Service d'Urologie, Centre de Recherches Chirurgicales, CHU Henri Mondor, Créteil, France. rene.yiou@hmn.ap-hop-paris.fr
Zini
Laurent
L
Lecoeur
Constant
C
Biserte
Jacques
J
Abbou
Claude
C
Atala
Antony
A
Chopin
Dominique
D
D000818:Animals; D017690:Cell Transplantation / Q000639:trends; D004195:Disease Models, Animal; D005544:Forecasting; D006801:Humans; D018482:Muscle, Skeletal / Q000502:physiology; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology; D012038:Regeneration; D014521:Urethra / Q000502:physiology; D014522:Urethral Diseases / Q000150:complications / Q000628:therapy*; D014550:Urinary Incontinence, Stress / Q000209:etiology / Q000628:therapy*