[Effect of myelopeptide 2 on the immunization of guinea pigs with live measles vaccine].
A model is suggested to study the effects the myelopeptide 2 (MP2) immunomodulator on the results of live measles rash immunized by vaccine. Guinea pigs were found to respond to live measles vaccine L-16 the way man does, i.e. the antibodies' level in their sera was increasing until days 28-56 after a single intramuscular vaccine injection. An intramuscular injection of the MP2 immunomodular, made alongside with vaccination, was demonstrated to enhance the immune response to the measles vaccine and to induce its action. Finally, it was for the first time, that the possibility was proven to enhance the action of the live measles vaccine by an immunomodulator.
Liashenko
V A
VA
Mikhaĭlova
A A
AA
Aleksander
S K
SK
Iuminova
N V
NV
Fonina
L A
LA
Kolyshkin
V M
VM
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007155:Immunologic Factors / Q000008:administration & dosage*; D007273:Injections, Intramuscular; D008457:Measles / Q000097:blood / Q000276:immunology*; D008458:Measles Vaccine / Q000276:immunology*; D018103:Morbillivirus / Q000276:immunology; D009842:Oligopeptides / Q000008:administration & dosage*; D013997:Time Factors; D014611:Vaccination
D000914:Antibodies, Viral; D007155:Immunologic Factors; D008458:Measles Vaccine; D009842:Oligopeptides; C048617:myelopeptides