title: Saline irrigated catheter ablation for pulmonary vein isolation in pigs: an experimental model.
abstract: Focal AF is amenable to radical cure by RF ablation within the PV. The primary purpose of this study was to compare lesion characteristics for irrigated versus standard ablation using three power settings for PV isolation in pigs. Secondary analyses were the comparisons of ablation time and temperature characteristics, and evaluation of short-term safety in the pig model. In 20 pigs from 25 to 35 kg in weight, transseptal catheterization was performed and then the ablation catheter was advanced into the PV. RF energy was delivered to the ostium of the PV until its isolation was achieved. The animals were euthanized 1 week after ablation for pathological examination. Electrophysiological isolation of the PV was achieved, although it was difficult to achieve a complete circumferencial lesion in the ostium of the PV. Both of these catheters can produce transmural necrosis, even using 15 W of power. The authors did not see any stenosis of the PV. This might be due to the low energy delivery and the short follow-up. Pulmonary hemorrhage was present in two animals with 50 W of power, high energy output is dangerous for the ablation of the PV.
authors.affiliation: Arrhythmia Unit, Ramón y Cajal Hospital, Department of Medicine, Alcalá University, Madrid, Spain.
authors.forename: Jian
authors.initials: J
authors.lastname: Peng
authors.forename: Antonio H
authors.initials: AH
authors.lastname: Madrid
authors.forename: Alberto
authors.initials: A
authors.lastname: Palmeiro
authors.forename: Jose Maria G
authors.initials: JM
authors.lastname: Rebollo
authors.forename: Lilianna
authors.initials: L
authors.lastname: Limón
authors.forename: Sebastian
authors.initials: S
authors.lastname: Nannini
authors.forename: Irene
authors.initials: I
authors.lastname: Marín
authors.forename: Enrique
authors.initials: E
authors.lastname: Bernal
authors.forename: Carlos
authors.initials: C
authors.lastname: Escobar
authors.forename: Maria
authors.initials: M
authors.lastname: Viana
authors.forename: Concepcion
authors.initials: C
authors.lastname: Moro
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000628:therapy*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D008297:Male; D011667:Pulmonary Veins / Q000033:anatomy & histology / Q000473:pathology / Q000601:surgery*; D012965:Sodium Chloride; D013552:Swine; D013696:Temperature; D007507:Therapeutic Irrigation; D013997:Time Factors
chemical_list: D012965:Sodium Chloride