Allochronic overlapping malignancies after renal transplantation in a patient with p53 gene mutation: report of a case.
We report a rare case of the development of various tumors over a 16-year period after renal transplantation. A 56-year-old woman underwent renal transplantation using a US kidney. Immunosuppressive treatment consisted of a triple regimen of methylprednisolone, azathioprine, and mizoribine. Left breast cancer was diagnosed 9 years after the renal transplantation, then colon cancers and meningeal epidermal meningioma were diagnosed, 10 years and 12 years post-transplant, respectively. During the investigations for the breast and colon cancers, a p53 gene mutation was detected. A deterioration of renal function was found 16 years after the transplant and graft biopsy confirmed chronic rejection. We suggest that the effects of the immunosuppressive drugs combined with the p53 gene abnormality accelerated tumor development in this patient.
Kitayama
Teruhiko
T
Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Marubayashi
Seiji
S
Hayamizu
Keisuke
K
Tashiro
Hirotaka
H
Ohdan
Hideki
H
Ikeda
Satoshi
S
Okimoto
Tatsuya
T
Okajima
Masazumi
M
Kataoka
Tuyoshi
T
Sugino
Keizo
K
Asahara
Toshimasa
T
Fukuda
Yasuhiko
Y
Dohi
Kiyohiko
K
D001379:Azathioprine / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000209:etiology / Q000235:genetics; D003110:Colonic Neoplasms / Q000209:etiology* / Q000235:genetics / Q000601:surgery; D003111:Colonic Polyps / Q000209:etiology / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D016158:Genes, p53; D006084:Graft Rejection; D006391:Hemangioma / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000556:secondary; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D009154:Mutation; D009378:Neoplasms, Multiple Primary; D011183:Postoperative Complications; D012263:Ribonucleosides / Q000008:administration & dosage
D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D001379:Azathioprine; D008775:Methylprednisolone