A supercode for inflammation.
Siegelman and colleagues demonstrate unexpected synergism of CD44 and VLA-4 during lymphocyte extravasation. This is the first time that molecules mediating rolling and firm adhesion have been shown to associate biochemically leading to direct functional cooperation.
Dustin
Michael
M
New York University School of Medicine, Skirball Institute of Molecular Medicine, Department of Pathology, Program in Molecular Pathogenesis, 540 First Avenue, New York, NY 10016, USA.
D000818:Animals; D002448:Cell Adhesion / Q000276:immunology; D006801:Humans; D018960:Hyaluronan Receptors / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D039041:Integrin alpha4beta1 / Q000276:immunology*; D036904:Leukocyte Rolling / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D018960:Hyaluronan Receptors; D039041:Integrin alpha4beta1