Semecarpus anacardium L, nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property.
Traditionally S. anacardium is used for rejuvenation, rheumatoid arthritis, fever and neurological disorders. In the present study it was observed that a fraction of S. anacacrdium at dose of 1 mg/100 g body wt, significantly reduced serum cholesterol from 378.87 mg/dl in the rats fed with atherogenic diet (AD) to 197.99 mg/dl (45-52%) in the rats fed with AD diet and increased serum HDL-cholesterol (33-37%). The same fraction also inhibited LPS induced NO production in the culture activated rat peritoneal macrophages in the dose dependent manner with IC50 value at 50 ng/ml of the culture medium. The drug in the above doses was completely safe and non-toxic, (no change in the enzymes), to liver and kidney functions.
Tripathi
Y B
YB
Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. yamini30@sify.com
Pandey
R S
RS
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000378:metabolism; D004036:Diet, Atherogenic; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008111:Liver Function Tests; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D009754:Nuts; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D031023:Semecarpus / Q000737:chemistry*
D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide; D002784:Cholesterol