title: Gamma/beta oscillation and sensory gating deficit in schizophrenia.
abstract: Sensory gating can be measured by the suppression of auditory evoked potentials in a paired-click paradigm. The normal gating of the P50 response to the second stimulus (S2) is impaired in many schizophrenic patients. Various in vitro and in vivo evoked potential paradigms have shown that a stimulus evokes early gamma frequency oscillation, which is followed by beta frequency oscillation. The gamma-to-beta shift in response to the first stimulus (SI) in the paired-click paradigm may contain critical electrophysiological signals that modulate the S2 suppression. The results of the present study showed that post-SI beta frequency response was inversely correlated to the S2 P50 response in patients with schizophrenia.
authors.affiliation: Maryland Psychiatric Research Center, Department of Psychiatry, School of Medicine, University of Maryland, PO Box 21247, Baltimore, MD 21228, USA. ehong@mprc.umaryland.edu
authors.forename: L Elliot
authors.initials: LE
authors.lastname: Hong
authors.forename: Ann
authors.initials: A
authors.lastname: Summerfelt
authors.forename: Robert P
authors.initials: RP
authors.lastname: McMahon
authors.forename: Gunvant K
authors.initials: GK
authors.lastname: Thaker
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000328:Adult; D001611:Beta Rhythm / Q000379:methods*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012559:Schizophrenia / Q000503:physiopathology*