[The relationship between malignant transformation and fertilization types of hydatidiform moles].
OBJECTIVE
To study the relationship between malignant transformation and fertilization types of hydatidiform moles (HM).


METHODS
Fifty four HM specimens were analyzed by using multiplex STR-PCR (9 loci) to determine the fertilization types and all patients were followed-up for the human chorionic gonadotropin (hCG) over 1 year.


RESULTS
Total malignant transformation cases were 10 in all the 54 HM. Ggenetics complete hydatidiform moles (g-CHM) with DNA from only paternal origin, were observed in 38 cases including 28 homozygote and 10 heterozygote cases. In homozygote and heterozygote cases,malignant transformation occurred in 8 cases of the empty eggs fertilized by single sperms and 2 by double sperms respectively. In all the 54 HMs, 16 cases of DNA from parents were genetic partial hydatidiform moles (g-PHM), and no malignant transformation occurred in each haploidy egg fertilized by double sperms.


CONCLUSIONS
(1)Genetic complete hydatidiform moles (g-CHM) showed a higher malignant transformation risk than genetic partial hydatidiform moles (g-PHM) (P=0.024 2); (2)There was no significant difference in malignant transformation between homozygote and heterozygote of g-CHM (P=0.699).
Zhang
Xiao-wei
XW
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100083, China. zhangxw@public.fhnet.cn.net
Zhu
Hao-bin
HB
Gao
Ya-qin
YQ
Wu
Shu-ying
SY
Gao
Rong-lian
RL
Han
Jin-song
JS
Wang
Xiu-yun
XY
Wang
Rui
R
Guo
Hong-yan
HY
Zhao
Yang-yu
YY
Zhao
Wen-qiu
WQ
D002471:Cell Transformation, Neoplastic; D005260:Female; D005306:Fertilization; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D020080:Tandem Repeat Sequences; D014594:Uterine Neoplasms / Q000235:genetics* / Q000469:parasitology / Q000503:physiopathology