Drug resistance in Chromobacterium violaceum.
Chromobacterium violaceum is a free-living bacterium commonly found in aquatic habitats of tropical and subtropical regions of the world. This bacterium is able to produce a large variety of products of biotechnological and pharmacological use. Although C. violaceum is considered to be non-pathogenic, some cases of severe infections in humans and other animals have been reported. Genomic data on the type strain ATCC 12472(T) has provided a comprehensive basis for detailed studies of pathogenicity, virulence and drug resistance genes. A large number of open reading frames associated with various mechanisms of drug resistance were found, comprising a remarkable feature of this organism. Amongst these, beta-lactam (penicillin and cephalosporin) and multidrug resistance genes (drug efflux pumps) were the most numerous. In addition, genes associated with bacitracin, bicyclomycin, chloramphenicol, kasugamycin, and methylenomycin were also found. It is postulated that these genes contribute to the ability of C. violaceum to compete with other bacteria in the environment, and also may help to explain the common drug resistance phenotypes observed in infections caused by this bacterium.
Fantinatti-Garboggini
Fabiana
F
Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas, Divisão de Recursos Microbianos, Universidade Estadual de Campinas, Caixa Postal 6109, 13081-970 Campinas, SP, Brasil.
Almeida
Rosana de
Rd
Portillo
Vinícius do Amaral
Vdo A
Barbosa
Tércio A P
TA
Trevilato
Peterson Beltramini
PB
Neto
Cícero Eduardo Ramalho
CE
Coêlho
Rosângela Duarte
RD
Silva
Denise Wanderlei
DW
Bartoleti
Luciana Aparecida
LA
Hanna
Ebert Seixas
ES
Brocchi
Marcelo
M
Manfio
Gilson P
GP
D000900:Anti-Bacterial Agents; D002861:Chromobacterium / Q000187:drug effects / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D016366:Open Reading Frames / Q000235:genetics*
D000900:Anti-Bacterial Agents