title: Leucosceptrine--a novel sesterterpene with prolylendopeptidase inhibitory activity from Leucosceptrum canum.
abstract: A novel sesterterpene, leucosceptrine, was isolated from the medicinal plant Leucosceptrum canum from Nepal. The structure was determined by single-crystal X-ray diffraction and spectroscopic techniques. The biosynthesis of leucosceptrine (1) is proposed here. Leucosceptrine (1) exhibited prolylendopeptidase inhibitory activity.
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Rosa
authors.initials: R
authors.lastname: Ranjit
authors.forename: Atta-Ur-Rahman
authors.initials: AU
authors.lastname: Atta-Ur-Rahman
authors.forename: Tirtha Maiya
authors.initials: TM
authors.lastname: Shrestha
authors.forename: Amsha
authors.initials: A
authors.lastname: Yasin
authors.forename: Masood
authors.initials: M
authors.lastname: Parvez
mesh_terms: D018360:Crystallography, X-Ray; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009390:Nepal; D010946:Plants, Medicinal / Q000737:chemistry; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D015842:Serine Proteinase Inhibitors; D013729:Terpenes; C490747:leucosceptrine; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases