title: Effects of acute hypercholesterolemia on blood pressure and pressor response to norepinephrine in rats.
abstract: To examine if high cholesterol in blood acutely affects the blood pressure, we partly exchanged the blood of normal rats for that of hypercholesterolemic rats. Male Sprague-Dawley rats were fed for 8 weeks with a high-cholesterol diet (4% cholesterol; HC) or a normal diet (NC). The rats were catheterized; and blood of animals in NC was partly exchanged with that of HC (N-H) or other animals in NC (N-N). Systolic blood pressure (SBP) and the pressor response to norepinephrine (NE) in N-H were compared with those of N-N. Serum lipids and malondialdehyde (MDA), and urinary excretion of protein (UP) and NE (UNE) were determined. After 8 weeks, SBP, serum total cholesterol (TC), MDA, UP and UNE were higher in the HC. Blood exchange caused an increase in TC, MDA and SBP in only the N-H. Increases in SBP caused by NE injection were rather less in the N-H than in the N-N. The blood pressure increase induced by a high-cholesterol diet seemed to be caused by certain factors in the blood of hypercholesterolemic rats. Excessive lipid oxidation induced by hypercholesterolemia may be involved in the blood pressure elevation.
authors.affiliation: Department of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Atarashi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ishiyama
authors.forename: Mayumi
authors.initials: M
authors.lastname: Minami
authors.forename: Masao
authors.initials: M
authors.lastname: Takagi
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002791:Cholesterol, Dietary / Q000633:toxicity; D005078:Exchange Transfusion, Whole Blood; D006937:Hypercholesterolemia / Q000503:physiopathology*; D006973:Hypertension / Q000139:chemically induced; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009638:Norepinephrine / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011507:Proteinuria / Q000209:etiology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002791:Cholesterol, Dietary; D008055:Lipids; D008315:Malondialdehyde; D009638:Norepinephrine