Changes in antioxidant enzyme activity and malondialdehyde level in patients with age-related macular degeneration.
Age-related macular degeneration is the leading cause of legal blindness in the developed world, and yet its pathogenesis remains poorly understood. Oxidative stress may play a major role in the etiology and pathogenesis of age-related disorders such as age-related macular degeneration. Catalase is an antioxidant enzyme which plays an important role in the detoxification of free oxygen radicals. Malondialdehyde is a marker that shows free radical damage. We have measured the erythrocyte activity of catalase and the serum level of malondialdehyde in 30 patients with age-related macular degeneration and 60 healthy subjects. Patients with age-related macular degeneration showed significantly lower catalase activity compared to healthy subjects (p = 0.002). Plasma malondialdehyde level of the patient group was significantly higher than that of the controls (p = 0.038).
Yildirim
Ozlem
O
Department of Ophthalmology, Faculty of Medicine, Mersin University, Mersin, Turkey. dryildrimoz@hotmail.com
Ateş
Nurcan Aras
NA
Tamer
Lülüfer
L
Muşlu
Necati
N
Ercan
Bahadir
B
Atik
Uğur
U
Kanik
Arzu
A
D000368:Aged; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D012727:Sex Characteristics
D008315:Malondialdehyde; D002374:Catalase