RNA polymerase II structure, and organization of the preinitiation complex.
Recent X-ray and cryo-electron microscopy studies have provided information about the basal eukaryotic transcription machinery and about Mediator, the complex involved in transcription regulation during initiation. On the basis of this structural information, a model describing the minimal transcription complex and its interaction with Mediator has been proposed. The model provides insight into the possible mechanisms of transcription initiation and regulation.
Asturias
Francisco J
FJ
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. asturias@scripps.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry; D006801:Humans; D046911:Macromolecular Substances; D008958:Models, Molecular; D012319:RNA Polymerase II / Q000737:chemistry*; D012441:Saccharomyces cerevisiae; D019473:Transcription Factors, TFII / Q000737:chemistry*; D014158:Transcription, Genetic / Q000235:genetics
D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D019473:Transcription Factors, TFII; D012319:RNA Polymerase II