Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas.
The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression.
Broussard
Dana R
DR
Section of Microbiology and Molecular Genetics and Institute of Cellular and Molecular Biology, Austin, Texas 78712, USA.
Lozano
Mary M
MM
Dudley
Jaquelin P
JP
D000818:Animals; D016399:Lymphoma, T-Cell / Q000821:virology*; D051379:Mice; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D016133:Polymerase Chain Reaction; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism; D018168:Receptors, Retinoic Acid / Q000235:genetics* / Q000378:metabolism; D011988:Receptors, Thyroid Hormone / Q000235:genetics* / Q000378:metabolism; D012190:Retroviridae / Q000235:genetics / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000821:virology; D014412:Tumor Virus Infections / Q000821:virology; D016662:Virus Integration
D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D016271:Proto-Oncogene Proteins c-myc; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; C539901:Rorc protein, mouse