title: Dobutamine-induced eosinophilia.
abstract: A man with dilated cardiomyopathy presented with decompensated heart failure and marked eosinophilia. After extensive clinical and laboratory evaluation for hypereosinophilic syndrome, including a myocardial biopsy, it was determined by means of rechallenge (second dobutamine infusion) that the patient was afflicted with dobutamine-induced eosinophilia. This report is important because of the high utilization rate of this drug in a sick population. Simply discontinuing it or switching to another agent can avert the high cost and risk of the evaluation for hypereosinophilic syndrome in this compromised group of patients.
authors.affiliation: Division of Cardiology, The Ohio State University Medical Center, Columbus, Ohio, USA.
authors.forename: Osama M
authors.initials: OM
authors.lastname: El-Sayed
authors.forename: Rehab R
authors.initials: RR
authors.lastname: Abdelfattah
authors.forename: Robert
authors.initials: R
authors.lastname: Barcelona
authors.forename: Carl V
authors.initials: CV
authors.lastname: Leier
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000188:drug therapy; D002316:Cardiotonic Agents / Q000009:adverse effects*; D004280:Dobutamine / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine