title: Whole-body hyperthermia in combination with platinum-containing drugs in patients with recurrent ovarian cancer.
abstract: BACKGROUND
  Patients with advanced ovarian cancer have an enormous risk of relapse after primary therapy, and the prognosis for these patients remains bleak. Primary and acquired resistance of tumor cells to antineoplastic drugs is a major cause of the limited effectiveness of chemotherapy. The effect of whole-body hyperthermia (WBH) combined with platinum-containing chemotherapy in the treatment of recurrent ovarian cancer was examined in this study.
  
  
  METHODS
  Patients studied were those with pathologically verified epithelial ovarian cancer after operation who had had first-line chemotherapy with cisplatin or carboplatin, and relapsed. All 21 patients were treated with WBH and platinum-based chemotherapy. During the WBH, a core temperature of 41.5 degrees C-42 degrees C was attained in the rectum. We combined the WBH with 300-400 mg/dl artificial hyperglycemia. The plateau temperature was held over a period of, on average, 90 +/- 30 min, and the artificial hyperglycemia, on average, 240 +/- 30 min. WBH was repeated at the beginning of each new chemotherapy cycle.
  
  
  RESULTS
  One patient (4.8%) had a complete remission, 7 patients (33.3%) had a partial remission, stable disease was noted in 10 patients (47.6%), and 3 (14.3%) patients did not respond and had progressive disease. Median time to progression was 6.5 months, and median survival time, 16.5 months.
  
  
  CONCLUSIONS
  Our results validate the efficacy of WBH in the treatment of patients with recurrent platinum-resistant ovarian cancer. The overall tolerance of this treatment was good. The priority for all patients was an improvement in life quality; this was seen 3-4 days after WBH. The encouraging results should be confirmed in randomized studies. Patients with advanced ovarian cancer have an enormous risk of relapse after primary therapy, and the prognosis for these patients remains bleak. Primary and acquired resistance of tumor cells to antineoplastic drugs is a major cause of the limited effectiveness of chemotherapy. The effect of whole-body hyperthermia (WBH) combined with platinum-containing chemotherapy in the treatment of recurrent ovarian cancer was examined in this study.
authors.affiliation: St. George Hospital, Rosenheimer Str. 6-8, 83043, Bad Aibling, Germany. info@klinik-st-georg.de
authors.forename: Friedrich
authors.initials: F
authors.lastname: Douwes
authors.forename: Juri
authors.initials: J
authors.lastname: BogoviC
authors.forename: Ortrun
authors.initials: O
authors.lastname: Douwes
authors.forename: Friedrich
authors.initials: F
authors.lastname: Migeod
authors.forename: Christoph
authors.initials: C
authors.lastname: Grote
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016190:Carboplatin / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D009375:Neoplasms, Glandular and Epithelial / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000628:therapy*; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin