title: Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis.
abstract: The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9'-O-feruloyl-(-)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC(50) values of 1.8 and 3.9 microg/mL, respectively.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC. wupl@mail.ncku.edu.tw
authors.forename: Pei-Lin
authors.initials: PL
authors.lastname: Wu
authors.forename: Ta-Hsien
authors.initials: TH
authors.lastname: Chuang
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: He
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D002460:Cell Line; D004952:Esters; D031584:Hibiscus / Q000737:chemistry*; D006801:Humans; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D004952:Esters; D010666:Phenylpropionates