Using immunomagnetic technology and other means to facilitate stem cell homing.
If stem cell therapy is to be maximally effective, it is vital that progenitor (stem) cells get to the target tissue(s) and/or organ(s). Three methods of facilitating stem cell homing to target tissues are explored in this paper: (1) cobalt compounds such as cobalt phthalocyanines could be magnetically delivered to target tissue(s) and/or organ(s), and then subject to a brief pulsed magnetic field or ultrasound exposure suitable to induce mild hyperthermia with the result being the synthesis of cytokines that are chemoattractants to progenitor (stem) cells; (2) ferromagnetic nanobead particles could be tagged with antibodies specific to the target tissue(s) and/or organ(s) and infused into patients, followed by introduction of progenitor (stem) cells tagged with antibody-bound magnetic nanoparticles. This should result in passive attachment (stem cells to tagged tissue or organ); and (3) Reticulose, which stimulates the synthesis of the stem cell chemoattractant IL-8, could be magnetically guided to target tissue(s) and/or organ(s).
Payne
Anthony G
AG
Steenblock Research Institute, San Clemente, CA 92673, USA. dragpayne@yahoo.com
D001709:Biotechnology / Q000379:methods*; D002465:Cell Movement / Q000502:physiology* / Q000528:radiation effects; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D018189:Immunomagnetic Separation / Q000379:methods*; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000502:physiology* / Q000528:radiation effects