Isolation of Salmonella enterica serotype choleraesuis resistant to ceftriaxone and ciprofloxacin.
Salmonella enterica serotype choleraesuis (S choleraesuis) usually causes systemic infections in man that need antimicrobial treatment. We isolated a strain of S choleraesuis that was resistant to ceftriaxone and ciprofloxacin from a patient with sepsis. Ciprofloxacin resistance was associated with mutations in gyrA and parC, whereas the ampC gene (bla(CMY-2)), responsible for ceftriaxone resistance, was carried by a transposon-like mobile element. This element was found inserted into finQ of a potentially transmissible 140 kb plasmid, with an 8 bp direct repeat flanking the junction regions. The appearance of this resistant S choleraesuis is a serious threat to public health, and thus constant surveillance is warranted.
Chiu
C H
CH
Department of Clinical Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Su
L H
LH
Chu
C
C
Chia
J H
JH
Wu
T L
TL
Lin
T Y
TY
Lee
Y S
YS
Ou
J T
JT
D002443:Ceftriaxone / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010957:Plasmids; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D018805:Sepsis / Q000382:microbiology; D012703:Serotyping
D002939:Ciprofloxacin; D002443:Ceftriaxone