Late relapse of myelodysplasia after allogeneic transplantation concomitant with new presentation of invasive liposarcoma as a secondary neoplasm.
Second malignancies are uncommon events in the survivors of allogeneic transplant procedures, although they are increased compared to normal control populations. Among these malignancies, sarcomas are exceedingly rare. In addition, relapse of primary myelodysplasia rarely occurs after 5 years from the time of allogeneic transplantation. This report describes an unusual presentation of liposarcoma with concomitant relapse of underlying myelodysplasia developing in a patient 9 years after the first of two allogeneic transplantations.
Walker
L N
LN
Division of Hematology and Medical Oncology, Adult Bone Marrow Transplantation Program, Center for Hematologic Malignancies, Northwest Marrow Transplant Program, Oregon Health and Sciences University, Portland, OR 97239, USA.
Gatter
K
K
Sekhon
H S
HS
Maziarz
R T
RT
D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000209:etiology; D008080:Liposarcoma / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology / Q000628:therapy*; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology; D012008:Recurrence; D013995:Time; D014184:Transplantation, Homologous