Modulation of antioxidant potential in liver of mice by kernel oil of cashew nut (Anacardium occidentale) and its lack of tumour promoting ability in DMBA induced skin papillomagenesis.
Cashew nut shell oil has been reported to possess tumour promoting property. Therefore an attempt has been made to study the modulatory effect of cashew nut (Anlacardium occidentale) kernel oil on antioxidant potential in liver of Swiss albino mice and also to see whether it has tumour promoting ability like the shell oil. The animals were treated orally with two doses (50 and 100 microl/animal/day) of kernel oil of cashew nut for 10 days. The kernel oil was found to enhance the specific activities of SOD, catalase, GST, methylglyoxalase I and levels of GSH. These results suggested that cashew nut kernel oil had an ability to increase the antioxidant status of animals. The decreased level of lipid peroxidation supported this possibility. The tumour promoting property of the kernel oil was also examined and found that cashew nut kernel oil did not exhibit any solitary carcinogenic activity.
Singh
Bimala
B
Radiation and Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Kale
R K
RK
Rao
A R
AR
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D031021:Anacardium / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002273:Carcinogens / Q000633:toxicity; D002374:Catalase / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D007791:Lactoylglutathione Lyase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009754:Nuts / Q000737:chemistry; D010212:Papilloma / Q000139:chemically induced / Q000378:metabolism*; D010938:Plant Oils / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002273:Carcinogens; D010938:Plant Oils; D015127:9,10-Dimethyl-1,2-benzanthracene; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D007791:Lactoylglutathione Lyase; D005978:Glutathione