[Role of pericytes in mechanism of vessel neovascularisation in the regenerating connective tissue].
This work presents the data of electron microscopic study of cellular interrelations in the process of capillary growth in the regenerating connective tissue. The study was performed in 28 albino rats which have been implanted with different polymer nets in the muscle defects of anterior abdominal wall. A combined activation of both endothelial cells (EC) and pericytes was demonstrated during the earliest stages of angiogenesis. The pericytes, but not EC, were shown to form the frontal zone of growing capillary sprout by the synthesis of the extracellular matrix components ahead of migrating EC. The possible role of pericytes in the control of capillary development and growth in the regenerating tissue is discussed.
Banin
V V
VV
Department of Morphology, Russian State Medical University, Moscow.
D000818:Animals; D002196:Capillaries / Q000502:physiology / Q000648:ultrastructure; D003238:Connective Tissue / Q000098:blood supply* / Q000502:physiology; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020286:Pericytes / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D012038:Regeneration / Q000502:physiology*