title: [Lobular neoplasia].
abstract: The concept of lobular lesions has greatly evolved during the last 30 Years. This disease is still not fully understood and patient management is probably not always optimal. Changes in the histopathological categorization of the lobular changes should help us to better categorize high-risk lesions. The concept of lobular neoplasia conceived as simply a risk factor and not a precursor for subsequent development of invasive carcinoma is a subject of current debate. Molecular biology data and immunoprofiles isolate lobular phenotypes and link them to invasive cancer. Mass screening is challenging the current opinion that lobular disease cannot be detected by mammography. This raises the problem of the optimal management of patients with lobular neoplasia on needle core biopsies.
authors.affiliation: Institut Curie, 26 rue d'Ulm, 75005 Paris. brigitte.sigal@curie.net
authors.forename: Brigitte
authors.initials: B
authors.lastname: Sigal-Zafrani
authors.forename: Anne
authors.initials: A
authors.lastname: Vincent-Salomon
authors.forename: Frédérique
authors.initials: F
authors.lastname: Penault-Llorca
authors.forename: Xavier
authors.initials: X
authors.lastname: Sastre-Garau
mesh_terms: D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology; D018275:Carcinoma, Lobular / Q000737:chemistry / Q000145:classification / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008327:Mammography; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor