Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals.
In our event-related functional magnetic resonance imaging (fMRI) experiment, participants learned to select between two response options by trial-and-error, using feedback stimuli that indicated monetary gains and losses. The results of the experiment indicate that error responses and error feedback activate the same region of dorsal anterior cingulate cortex, suggesting that this region is sensitive to both internal and external sources of error information.
Holroyd
Clay B
CB
Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey 08544, USA. cholroyd@princeton.edu
Nieuwenhuis
Sander
S
Yeung
Nick
N
Nystrom
Leigh
L
Mars
Rogier B
RB
Coles
Michael G H
MG
Cohen
Jonathan D
JD
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology*; D005246:Feedback / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008606:Mental Processes / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*