[Immunotoxicologic assessment of transgenetic rice].
OBJECTIVE
To assess the immunotoxicologic aspect of transgenetic plant.


METHODS
BALB/C mice were fed with food composed by transgenic rice (into which cowpea trypsin inhibitor gene was introduced) or nontransgenetic rice (which has the same gene composition as the transgenic rice except for the cowpea trypsin inhibitor gene) for 30 days. All food is made according to the composition of AIN-93G. In the end, all kinds of immunotoxicologic indexes of mice of every group were compared such as body weight, guts index, blood routine test, lymphocyte sort, serum antibody titter, plaque forming cell, delayed hypersensitivity response, macrophage function test.


RESULTS
All immunotoxicologic indexes of mice fed either by transgenic rice or nontransgenetic rice have no differences to those of mice fed by normal food.


CONCLUSIONS
Transgenic rice is substantially equivilent to nontransgenetic rice in immunotoxicologic aspect.
Chen
Xiaoping
X
Institute of Nutrition and Food safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhuo
Qin
Q
Piao
Jianhua
J
Yang
Xiaoguang
X
D000818:Animals; D016827:CD8 Antigens / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012275:Oryza / Q000235:genetics* / Q000633:toxicity; D018532:Pisum sativum / Q000235:genetics; D010940:Plant Proteins / Q000235:genetics*; D030821:Plants, Genetically Modified / Q000633:toxicity*; D011897:Random Allocation; D013601:T-Lymphocytes / Q000276:immunology; D014361:Trypsin Inhibitors; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
D016827:CD8 Antigens; D010940:Plant Proteins; D014361:Trypsin Inhibitors; D000516:alpha-Amylases