Effect of single injection of pentylenetetrazole in a subconvulsive dose on Cl- conductance of the GABAA-receptor complex.
Muscimol-stimulated Cl(-)conductance in brain cortex synaptoneurosomes from Wistar rats decreased 15 min after single intraperitoneal injection of pentylenetetrazole in a subconvulsive dose. These changes reflected a decrease in functional activity of the GABA(A)-receptor/Cl(-)ionophore complex. Muscimol-stimulated Cl(-)conductance in synaptoneurosomes returned to normal 48 h after pentylenetetrazole administration.
Rebrov
I G
IG
Laboratory of Functional Neurochemistry, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow. irebrov2003@mail.ru
Karpova
M N
MN
Andreev
A A
AA
Kuzina
O S
OS
Kalinina
M S
MS
Abrosimov
I Yu
IY
Belykh
N P
NP
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D018118:Chloride Channels / Q000037:antagonists & inhibitors*; D002712:Chlorides / Q000378:metabolism; D003292:Convulsants / Q000008:administration & dosage / Q000494:pharmacology*; D004553:Electric Conductivity; D004827:Epilepsy / Q000503:physiopathology; D018756:GABA Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D007267:Injections; D008297:Male; D009118:Muscimol / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013574:Synaptosomes / Q000187:drug effects
D018118:Chloride Channels; D002712:Chlorides; D003292:Convulsants; D018756:GABA Antagonists; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D009118:Muscimol; D010433:Pentylenetetrazole