New prostanoids with cytotoxic activity from Taiwanese octocoral Clavularia viridis.
Bioassay-directed fractionation of the CH(2)Cl(2)-MeOH extract of Clavularia viridis collected in Taiwan has afforded seven new prostanoids, designated as 4-deacetoxyl-12-O-deacetylclavulone I (1), 4-deacetoxyl-12-O-deacetylclavulone II (2), bromovulone II (4), iodovulone II (5), 4-deacetoxyl-12-O-deacetylclavulone III (6), bromovulone III (7), and iodovulone III (8), in addition to seven known prostanoids (clavulones I, II, III, 7-acetoxy-7,8-dihydroiodovulone, chlorovulones II, III, and 4-deacetoxylclavulone II (3, claviridenone E)). The structures of compounds 1-8 were determined on the basis of 1D and 2D NMR techniques including COSY, HSQC, and HMBC experiments. Pharmacological study revealed that bromovulone III (7) and chlorovulone II exhibited the most promising cytotoxicity against human prostate (PC-3) and colon (HT29) cancer cells.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Cheng
Yuan-Bin
YB
Lin
Yu-Chi
YC
Guh
Jih-Hwa
JH
Teng
Che-Ming
CM
Ko
Chin-Lien
CL
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D011453:Prostaglandins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011471:Prostatic Neoplasms; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011453:Prostaglandins