Hepatitis C infection increases the risk of the modification of first highly active antiretroviral therapy in HIV-infected patients.
We assessed predictors of discontinuation or change of the first regimen of highly active antiretroviral therapy in 465 HIV-infected adults, in the first year. A total of 187 patients modified their regimen: 45 discontinuing and 142 changing because of clinical/virological failure, intolerance/toxicity or non-adherence. Predictors of modification of the regimen were hepatitis C seropositivity, liver cirrhosis, higher baseline viral load, sex (women had a lower risk) and calendar year (lower risk staring in 2000).
Ripamonti
Diego
D
Antiviral Therapy Unit, Infectious Diseases Department, Ospedali Riuniti di Bergamo, Bergamo, Italy.
Arici
Claudio
C
Pezzotti
Patrizio
P
Maggiolo
Franco
F
Ravasio
Laura
L
Suter
Fredy
F
D017088:AIDS-Related Opportunistic Infections / Q000150:complications*; D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D012307:Risk Factors