title: IMGT-ONTOLOGY for immunogenetics and immunoinformatics.
abstract: IMGT, the international ImMunoGeneTics information system(R) (http://imgt.cines.fr), is a high quality integrated knowledge resource specializing in immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) and related proteins of the immune system (RPI) of human and other vertebrates, created in 1989, by the Laboratoire d'ImmunoGenetique Moleculaire LIGM. IMGT provides a common access to standardized data which include nucleotide and protein sequences, oligonucleotide primers, gene maps, genetic polymorphisms, specificities, 2D and 3D structures. IMGT consists of several sequence databases (IMGT/LIGM-DB, IMGT/MHC-DB, IMGT/PRIMER-DB), one genome database (IMGT/GENE-DB) and one three-dimensional structure database (IMGT/3Dstructure-DB), interactive tools for sequence analysis (IMGT/V-QUEST, IMGT/JunctionAnalysis, IMGT/PhyloGene, IMGT/Allele-Align), for genome analysis (IMGT/GeneSearch, IMGT/GeneView, IMGT/LocusView) and for 3D structure analysis (IMGT/StructuralQuery), and Web resources ("IMGT Marie-Paule page") comprising 8000 HTML pages. IMGT other accesses include SRS, FTP, search by BLAST, etc. By its high quality and its easy data distribution, IMGT has important implications in medical research (repertoire in autoimmune diseases, AIDS, leukemias, lymphomas, myelomas), veterinary research, genome diversity and genome evolution studies of the adaptive immune responses, biotechnology related to antibody engineering (scFv, phage displays, combinatorial libraries) and therapeutical approaches (grafts, immunotherapy). IMGT is freely available at http://imgt.cines.fr.
authors.affiliation: IMGT, the international ImMunoGeneTics information system. Universite Montpellier II, Laboratoire d'ImmunoGenetique Moleculaire LIGM UPR CNRS 1142, Institut de Genetique Humaine IGH, Montpellier Cedex 5, France. lefranc@ligm.igh.cnrs.fr
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Lefranc
authors.forename: Véronique
authors.initials: V
authors.lastname: Giudicelli
authors.forename: Chantal
authors.initials: C
authors.lastname: Ginestoux
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bosc
authors.forename: Géraldine
authors.initials: G
authors.lastname: Folch
authors.forename: Delphine
authors.initials: D
authors.lastname: Guiraudou
authors.forename: Joumana
authors.initials: J
authors.lastname: Jabado-Michaloud
authors.forename: Séverine
authors.initials: S
authors.lastname: Magris
authors.forename: Dominique
authors.initials: D
authors.lastname: Scaviner
authors.forename: Valérie
authors.initials: V
authors.lastname: Thouvenin
authors.forename: Kora
authors.initials: K
authors.lastname: Combres
authors.forename: David
authors.initials: D
authors.lastname: Girod
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Jeanjean
authors.forename: Céline
authors.initials: C
authors.lastname: Protat
authors.forename: Mehdi
authors.initials: M
authors.lastname: Yousfi-Monod
authors.forename: Elodie
authors.initials: E
authors.lastname: Duprat
authors.forename: Quentin
authors.initials: Q
authors.lastname: Kaas
authors.forename: Christelle
authors.initials: C
authors.lastname: Pommié
authors.forename: Denys
authors.initials: D
authors.lastname: Chaume
authors.forename: Gérard
authors.initials: G
authors.lastname: Lefranc
mesh_terms: D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D005803:Genes, Immunoglobulin / Q000235:genetics; D019672:Genes, T-Cell Receptor / Q000235:genetics; D006801:Humans; D007125:Immunogenetics