title: Occupational exposure to welding fume among welders: alterations of manganese, iron, zinc, copper, and lead in body fluids and the oxidative stress status.
abstract: Welders in this study were selected from a vehicle manufacturer; control subjects were from a nearby food factory. Airborne manganese levels in the breathing zones of welders and controls were 1.45 +/- SD1.08 mg/m and 0.11 +/- 0.07 microg/m, respectively. Serum levels of manganese and iron in welders were 4.3-fold and 1.9-fold, respectively, higher than those of controls. Blood lead concentrations in welders increased 2.5-fold, whereas serum zinc levels decreased 1.2-fold, in comparison with controls. Linear regression revealed the lack of associations between blood levels of five metals and welder's age. Furthermore, welders had erythrocytic superoxide dismutase activity and serum malondialdehyde levels 24% less and 78% higher, respectively, than those of controls. These findings suggest that occupational exposure to welding fumes among welders disturbs the homeostasis of trace elements in systemic circulation and induces oxidative stress.
authors.affiliation: School of Public Health and Family Medicine, Capital University of Medical Sciences, Beijing, PRC.
authors.forename: Guojun Jane
authors.initials: GJ
authors.lastname: Li
authors.forename: Long-Lian
authors.initials: LL
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Lu
authors.forename: Ping
authors.initials: P
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000506:poisoning*; D000704:Analysis of Variance; D016022:Case-Control Studies; D003300:Copper / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood / Q000652:urine; D007854:Lead / Q000097:blood / Q000652:urine; D016014:Linear Models; D008297:Male; D008345:Manganese / Q000097:blood / Q000652:urine; D018384:Oxidative Stress; D014896:Welding; D015032:Zinc / Q000097:blood / Q000652:urine
chemical_list: D000395:Air Pollutants, Occupational; D007854:Lead; D008345:Manganese; D003300:Copper; D007501:Iron; D015032:Zinc