Dual positivity for cytoplasmic and perinuclear anti-neutrophil antibodies in a patient with Henoch-Schönlein purpura.
We herein describe the case of a 60-year-old man who presented clinical and histopathological evidence of Henoch-Schönlein purpura. Antineutrophil antibodies (ANCA) showed positive results on an enzyme-linked immunosorbent assay and immunofluorescence for anti-myeloperoxidase and anti-proteinase 3 antibodies. Dual positivity for both cytoplasmatic (C-ANCA) and perinuclear (P-ANCA) antineutrophil antibodies has been found previously in a small number of reports, but to our knowledge this is the first time the simultaneous presence of C-ANCA and P-ANCA has been observed in Henoch-Schönlein purpura.
Ferraz-Amaro
I
I
Servicio de Reumatología, Hospital Universitario de Canarias, Tenerife, Spain. iferraz@comtf.es
Herrero
M J
MJ
Jurado
A
A
Díaz-González
F
F
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D002467:Cell Nucleus / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D003593:Cytoplasm / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011695:IgA Vasculitis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin; D009195:Peroxidase / Q000276:immunology; D011241:Prednisone / Q000627:therapeutic use; D012697:Serine Endopeptidases / Q000276:immunology; D016896:Treatment Outcome
D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D007074:Immunoglobulin G; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin; D011241:Prednisone