title: Cytogenetic studies in T-cell acute lymphoblastic leukemia (1981-2002).
abstract: Chromosomal analysis was successfully performed in 34 of the 37 patients with T-cell acute lymphoblastic leukemia (ALL) seen at the University Hospital in Brest (France) between 1981 and 2002. A normal karyotype was observed in 29.4% of the patients. Numerical changes were rare, 79.2% of the abnormal karyotypes being pseudodiploid. All 24 abnormal karyotypes had at least a structural rearrangement. Translocations involving band 14q11, that contains the T-cell receptor (TCR) alpha and delta-genes, were observed in 8 patients; in 3 of them, a new partner chromosomal band was found. The short arms of chromosomes 11 and 12 were involved in 3 and 2 translocations respectively. Three patients had a del(6q). Our results are in agreement with those of the literature. Most of the recurrent abnormalities are different from those of B-lineage ALL. Some are known to involve TCR genes whereas others can lead to the discovery of new genes that are important to T-lineage leukemogenesis.
authors.affiliation: Service de Cytogénétique, Cytologie et Biologie de la Reproduction, CHU Morvan, Brest.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Douet-Guilbert
authors.forename: Frédéric
authors.initials: F
authors.lastname: Morel
authors.forename: Marie-Josée
authors.initials: MJ
authors.lastname: Le Bris
authors.forename: Angèle
authors.initials: A
authors.lastname: Herry
authors.forename: Geneviève
authors.initials: G
authors.lastname: Le Calvez
authors.forename: Véronique
authors.initials: V
authors.lastname: Marion
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Abgrall
authors.forename: Christian
authors.initials: C
authors.lastname: Berthou
authors.forename: Marc
authors.initials: M
authors.lastname: De Braekeleer
mesh_terms: D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D003582:Cytogenetics / Q000379:methods*; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D015458:Leukemia, T-Cell / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism; D014178:Translocation, Genetic