title: Comparison of the IntraLase femtosecond laser and mechanical keratomes for laser in situ keratomileusis.
abstract: OBJECTIVE
  To compare laser in situ keratomileusis (LASIK) results obtained with the femtosecond laser (IntraLase Corp.) to those obtained using 2 popular mechanical microkeratomes.
  
  
  METHODS
  Private practice, Greensboro, North Carolina, USA.
  
  
  METHODS
  This retrospective analysis compared LASIK outcomes with the femtosecond laser to those with the Carriazo-Barraquer (CB) microkeratome (Moria, Inc.) and the Hansatome microkeratome (Bausch & Lomb, Inc.). The 3 groups were matched for enrollment criteria and were operated on under similar conditions by the same surgeon.
  
  
  RESULTS
  There were 106 eyes in the IntraLase group, 126 eyes in the CB group, and 143 eyes in the Hansatome group. One day postoperatively, the uncorrected visual acuity (UCVA) results in the 3 groups were similar; at 3 months, the UCVA and the best spectacle-corrected visual acuity results were not significantly different. A manifest spheroequivalent of +/-0.50 diopter (D) was achieved in 91% of eyes in the IntraLase group, 73% of eyes in the CB group, and 74% of eyes in the Hansatome group (P<.01). IntraLase flaps were significantly thinner (P<.01) and varied less in thickness (P<.01) than flaps created with the other devices. The mean flap thickness was 114 microm +/- 14 (SD) with the IntraLase programmed for a 130 microm depth, 153 +/- 26 microm with the CB using a 130 microm plate, and 156 +/- 29 microm with the Hansatome using a 180 microm plate. Loose epithelium was encountered in 9.6% of eyes in the CB group and 7.7% of eyes in the Hansatome group but in no eye in the IntraLase group (P =.001). Surgically induced astigmatism in sphere corrections was significantly less with the IntraLase than with the other devices (P<.01).
  
  
  CONCLUSIONS
  The IntraLase demonstrated more predictable flap thickness, better astigmatic neutrality, and decreased epithelial injury than 2 popular mechanical microkeratomes.
authors.affiliation: Southeastern Eye Center, Greensboro, NC, USA. Guy1000@SurgiVision.biz
authors.forename: Guy M
authors.initials: GM
authors.lastname: Kezirian
authors.forename: Karl G
authors.initials: KG
authors.lastname: Stonecipher
mesh_terms: D000328:Adult; D001251:Astigmatism / Q000601:surgery*; D003319:Corneal Stroma / Q000473:pathology; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000295:instrumentation* / Q000379:methods*; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D012029:Refraction, Ocular / Q000502:physiology; D012189:Retrospective Studies; D012449:Safety; D013524:Surgical Flaps / Q000473:pathology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology