[The efficacy of two type of membrane plasma separator on the treatment of patients with chronic severe hepatitis B].
OBJECTIVE
In order to compare the efficacy of two kinds of membrane plasma separator on the treatment of patients with severe hepatitis B.


METHODS
63 cases suffering from chronic severe hepatitis B were divided into two groups, 25 cases were treated with plasma exchange using Evacure-4A membrane plasma separator (A group) or 38 cases were using PS-06 membrane plasma separator (B group). Both of them also were treated with similar basic medical treatment. The level of serum total bilirubin, non-conjugated bilirubin, prothrombin time and albumin were tested at baseline and the end of the treatment with PE.


RESULTS
Evacure-4A and PS-06 membrane plasma separators can effientively remove bilirubin, the levels of serum total bilirubin, non-conjugated bilirubin of all patients were significantly decreased after treated with PE. In A group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (464.2+/-193.8)micromol/L to (279.4+/-158.7)micromol/L, (293.5+/-129.1)micromol/L to (175.5+/-106.7)micromol/L (t=5.45, 10.36, P<0.01) respectively. In B group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (493.2+/-126.9)micromol/L to (299.7+/-96.5)micromol/L, (300.2+/-74.3)micromol/L to (171.5+/-53.1)micromol/L (t=5.17, 12.04, P<0.01) respectively. The level of serum albumin increased after treated with PE in A and B groups, to contrast with PS-06, the increasing percentage of albumin was higher when the patients were treated with PE using Evacure-4A membrane plasma separator [(8.3+/-0.7) % vs. (3.4+/-9.3) %, t = 2.76, P<0.01].


CONCLUSIONS
Evacure-4A membrane plasma separator may be better than PS-06 membrane plasma separator on the treatment of patients with chronic severe hepatitis B.
Zhang
Da-zhi
DZ
The Institute for Viral Hepatitis, Chongqing Medical University, Chongqing 400010, China.
Zhao
You-rong
YR
Zhang
Quan-hai
QH
Wang
Zhi-yi
ZY
Qin
Bo
B
He
Hua
H
Zhou
Zhi
Z
Guo
Shu-hua
SH
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange / Q000295:instrumentation*
D001663:Bilirubin