Investigation of racemisation in peptide synthesis within a micro reactor.
We demonstrate that peptides derived from alpha-amino acids may be prepared in a micro reactor. The peptides were prepared in 20 min with quantitative conversion, compared to batch reactions which require prolonged reaction times. We illustrate that by using dilute reagent concentrations and short reaction times, less racemisation is observed in micro reactions than in bulk reactions.
Watts
Paul
P
Department of Chemistry, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
Wiles
Charlotte
C
Haswell
Stephen J
SJ
Pombo-Villar
Esteban
E
D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000138:chemical synthesis*; D013237:Stereoisomerism
D007202:Indicators and Reagents; D010455:Peptides