Leucosceptrine--a novel sesterterpene with prolylendopeptidase inhibitory activity from Leucosceptrum canum.
A novel sesterterpene, leucosceptrine, was isolated from the medicinal plant Leucosceptrum canum from Nepal. The structure was determined by single-crystal X-ray diffraction and spectroscopic techniques. The biosynthesis of leucosceptrine (1) is proposed here. Leucosceptrine (1) exhibited prolylendopeptidase inhibitory activity.
Choudhary
Muhammad Iqbal
MI
H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Ranjit
Rosa
R
Atta-Ur-Rahman
Atta-Ur-Rahman
AU
Shrestha
Tirtha Maiya
TM
Yasin
Amsha
A
Parvez
Masood
M
D018360:Crystallography, X-Ray; D019686:Lamiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D009390:Nepal; D010946:Plants, Medicinal / Q000737:chemistry; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D015842:Serine Proteinase Inhibitors; D013729:Terpenes; C490747:leucosceptrine; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases