PheP, a putative amino acid permease of Staphylococcus aureus, contributes to survival in vivo and during starvation.
PheP, a putative amino acid permease in Staphylococcus aureus, contributes to starvation survival under glucose-limiting conditions and virulence. A pheP mutation led to poor growth after microaerobic or anaerobic incubation on pig serum agar, which was recovered by phenylalanine addition. Genetic complementation of pheP restored growth and starvation survival.
Horsburgh
Malcolm J
MJ
Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield, S10 2TN, United Kingdom.
Wiltshire
Michael D
MD
Crossley
Howard
H
Ingham
Eileen
E
Foster
Simon J
SJ
D026905:Amino Acid Transport Systems / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D010649:Phenylalanine / Q000378:metabolism; D013203:Staphylococcal Infections / Q000209:etiology; D013211:Staphylococcus aureus / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity; D013552:Swine; D014774:Virulence
D026905:Amino Acid Transport Systems; D004269:DNA, Bacterial; D010649:Phenylalanine