Quickening the pace: looking into the heart of HCN channels.
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to a wide range of physiological functions and regulate cardiac and neuronal pacemaker activity. Here, we review recent advances in three areas: the polarity of the S4 movement with hyperpolarization, the location of the activation gate, and the structure of the C-terminal C linker and CNBD.
Rosenbaum
Tamara
T
University of Washington, Department of Physiology and Biophysics, Box 357290, Seattle, WA 98195, USA.
Gordon
Sharona E
SE
D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000737:chemistry / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology*; D015221:Potassium Channels
D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D015221:Potassium Channels