title: Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries.
abstract: A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either an aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.
authors.affiliation: Drug Design Group, Progen Industries Ltd, 2806 Ipswich Rd, Darra, Qld 4076, Australia.
authors.forename: Ligong
authors.initials: L
authors.lastname: Liu
authors.forename: Cai
authors.initials: C
authors.lastname: Ping Li
authors.forename: Siska
authors.initials: S
authors.lastname: Cochran
authors.forename: Vito
authors.initials: V
authors.lastname: Ferro
mesh_terms: D016220:Fibroblast Growth Factor 1 / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000737:chemistry; D006001:Glycoconjugates / Q000737:chemistry*; D018716:Molecular Mimicry; D013431:Sulfates / Q000737:chemistry*; D020349:Surface Plasmon Resonance
chemical_list: D006001:Glycoconjugates; D013431:Sulfates; D016222:Fibroblast Growth Factor 2; D016220:Fibroblast Growth Factor 1