title: Correlation of immunohistochemically detected HER-2/neu (c-erbB-2) with histological stage and perineural invasion in pancreatic cancer.
abstract: OBJECTIVE
  HER-2/neu (c-erbB-2) oncoprotein is a transmembrane glycoprotein and may function as a growth factor being involved in the regulation of cell growth and cell transformation. c-erbB-2 was correlated with established outcome factors in pancreatic cancer.
  
  
  METHODS
  We performed an analysis of 100 patients with pancreatic cancer using an immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue samples in order to determine HER-2/neu oncoprotein expression along with stage and perineural involvement.
  
  
  RESULTS
  HER-2/neu oncoprotein was expressed in the tumors of 21 patients (21%).
  
  
  CONCLUSIONS
  Histologic stage, and perineural invasion did not correlate with HER-2/neu oncoprotein.
authors.affiliation: Department of Cytology, General Hospital of Chania, Crete, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Tamiolakis
authors.forename: I
authors.initials: I
authors.lastname: Venizelos
authors.forename: C
authors.initials: C
authors.lastname: Simopoulos
authors.forename: A
authors.initials: A
authors.lastname: Kotini
authors.forename: T
authors.initials: T
authors.lastname: Jivannakis
authors.forename: N
authors.initials: N
authors.lastname: Papadopoulos
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D010446:Peptide Fragments / Q000378:metabolism*; D010502:Perineum / Q000473:pathology*
chemical_list: C445779:HER-2-derived peptide 884-899; D010446:Peptide Fragments