Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia.
Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show that supernatants of HZ and HZ-fed-monocytes, and 4-hydroxynonenal generated by them, inhibited progenitor growth.
Giribaldi
Giuliana
G
Ulliers
Daniela
D
Schwarzer
Evelin
E
Roberts
Irene
I
Piacibello
Wanda
W
Arese
Paolo
P
D000447:Aldehydes / Q000494:pharmacology*; D000740:Anemia / Q000209:etiology*; D000818:Animals; D002478:Cells, Cultured; D004920:Erythropoiesis / Q000187:drug effects*; D006420:Hemeproteins / Q000494:pharmacology*; D006801:Humans; D008288:Malaria / Q000097:blood*; D010961:Plasmodium / Q000737:chemistry / Q000472:pathogenicity
D000447:Aldehydes; D006420:Hemeproteins; C020753:hemozoin; C027576:4-hydroxy-2-nonenal