Search for poliovirus long-term excretors among patients affected by agammaglobulinemia.
Patients with agammaglobulinemia may excrete enteroviruses, including vaccine-derived poliovirus, for prolonged periods of time. This poses a risk to the patients but it also may pose a risk to the population after eradication of poliovirus and the cessation of routine vaccination. To assess this risk, a pilot study was performed to identify potential poliovirus long-term excretors in a cohort of 38 patients with a definite/presumptive diagnosis of X-linked agammaglobulinemia (XLA). Stool samples were analyzed to detect any polio or other enteroviruses replicating in the gut and neutralizing antibodies against polioviruses were measured in the sera. No viruses were isolated from the stool samples and most sera had neutralizing antibody levels against all three poliovirus serotypes considered by the WHO to be protective in immunocompetent individuals. This suggests that long-term excretion of enteroviruses in patients with agammaglobulinemia is relatively uncommon.
Fiore
Lucia
L
Laboratory of Virology, Istituto Superiore di Sanità, Rome, 00161, Italy. fiore@iss.it
Plebani
Alessandro
A
Buttinelli
Gabriele
G
Fiore
Stefano
S
Donati
Valentina
V
Marturano
Jill
J
Soresina
Annarosa
A
Martire
Baldassarre
B
Azzari
Chiara
C
Nigro
Giovanni
G
Cardinale
Fabio
F
Trizzino
Antonino
A
Pignata
Claudio
C
Alvisi
Patrizia
P
Anastasio
Elisa
E
Bossi
Grazia
G
Ugazio
Alberto G
AG
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D005243:Feces / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D010865:Pilot Projects; D017955:Poliovirus / Q000302:isolation & purification*; D011055:Poliovirus Vaccine, Oral / Q000276:immunology; D017201:Virus Shedding
D000914:Antibodies, Viral; D011055:Poliovirus Vaccine, Oral