Regulation of ion channel expression.
A potentially important mechanism controlling ion channel expression is homeostatic regulation, which can act to maintain a stable electrophysiological phenotype in cardiac myocytes as well as to provide plasticity in response to genetic, pathological, or pharmacological insults. The capabilities and limitations of the homeostatic regulatory mechanisms that contribute to the control of cardiac ion channel expression are the primary topic of this review.
Rosati
Barbara
B
Department of Physiology and Biophysics, Institute of Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, NY, USA.
McKinnon
David
D
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D025461:Feedback, Physiological; D005544:Forecasting; D018507:Gene Expression Regulation, Developmental; D006168:Guinea Pigs; D006706:Homeostasis; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology*; D008322:Mammals / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000378:metabolism*; D051381:Rats
D007473:Ion Channels