Meningeal relapse in a patient with acute promyelocytic leukemia: a case report and review of the literature.
The involvement of central nervous system is rare in acute promyelocytic leukemia (APL). We report a APL patient of a 41 yr-old Korean male who presented with fever and petechia. Complete molecular remission was achieved with all-trans retinoic acid (ATRA), idarubicin, and cytarabine. Ten months later, he complained of a mild headache. The results of the physical examination and the complete blood counts were normal. The examination of cerebrospinal fluid showed the presence of promyelocyte. Bone marrow studies showed cytogenetic remission but with molecular relapse. He was treated with intrathecal and systemic chemotherapy.
Bae
Sung Hwa
SH
Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, Korea.
Ryoo
Hun Mo
HM
Cho
Hee Soon
HS
Lee
Jae Lyun
JL
Lee
Kyung Hee
KH
Hyun
Myung Soo
MS
D000328:Adult; D042381:Granulocyte Precursor Cells; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D008297:Male; D008578:Meninges; D012008:Recurrence