Effect of tetrachloromethane on the immune system.
Acute poisoning with tetrachloromethane in a dose of 0.75 LD(50) suppressed humoral and cell immune reactions in Wistar rats. Immunotoxicity of tetrachloromethane is realized via initiation of lipid peroxidation and inhibition of acetylcholine esterase in T lymphocytes and alpha-naphthyl AS-acetate esterase and alpha-naphthyl butyrate esterase in splenocytes.
Zabrodskii
P F
PF
Saratov Military Institute of Radiational, Chemical, and Biological Protection. pz@renet.com.ru
Germanchuk
V G
VG
Kirichuk
V F
VF
Karpenko
N I
NI
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000276:immunology* / Q000378:metabolism; D004950:Esterases / Q000032:analysis / Q000187:drug effects; D007107:Immune System / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D051381:Rats; D013601:T-Lymphocytes / Q000187:drug effects* / Q000201:enzymology
D002251:Carbon Tetrachloride; D004950:Esterases