title: Synthesis and biochemical properties of E-ring modified luotonin A derivatives.
abstract: Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.
authors.affiliation: Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22901, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Cagir
authors.forename: Shannon H
authors.initials: SH
authors.lastname: Jones
authors.forename: Brian M
authors.initials: BM
authors.lastname: Eisenhauer
authors.forename: Rong
authors.initials: R
authors.lastname: Gao
authors.forename: Sidney M
authors.initials: SM
authors.lastname: Hecht
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry* / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D011758:Pyrroles; D011809:Quinones; D059004:Topoisomerase I Inhibitors; C480761:luotonin A