title: Indoline derivatives as 5-HT(2C) receptor agonists.
abstract: A series of 1-(1-indolinyl)-2-propylamines was synthesised and evaluated as 5-HT(2C) receptor agonists for the treatment of obesity. The general methods of synthesis of the precursor indoles are described. The functional efficacy and radioligand binding data for all of the compounds at 5-HT(2) receptor subtypes are reported. A number of compounds were found to reduce food intake in rats after oral administration.
authors.affiliation: Vernalis Research Ltd, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, Berkshire RG41 5UA, UK. j.bentley@vernalis.com
authors.forename: J M
authors.initials: JM
authors.lastname: Bentley
authors.forename: D R
authors.initials: DR
authors.lastname: Adams
authors.forename: D
authors.initials: D
authors.lastname: Bebbington
authors.forename: K R
authors.initials: KR
authors.lastname: Benwell
authors.forename: M J
authors.initials: MJ
authors.lastname: Bickerdike
authors.forename: J E P
authors.initials: JE
authors.lastname: Davidson
authors.forename: C E
authors.initials: CE
authors.lastname: Dawson
authors.forename: C T
authors.initials: CT
authors.lastname: Dourish
authors.forename: M A J
authors.initials: MA
authors.lastname: Duncton
authors.forename: S
authors.initials: S
authors.lastname: Gaur
authors.forename: A R
authors.initials: AR
authors.lastname: George
authors.forename: P R
authors.initials: PR
authors.lastname: Giles
authors.forename: R J
authors.initials: RJ
authors.lastname: Hamlyn
authors.forename: G A
authors.initials: GA
authors.lastname: Kennett
authors.forename: A R
authors.initials: AR
authors.lastname: Knight
authors.forename: C S
authors.initials: CS
authors.lastname: Malcolm
authors.forename: H L
authors.initials: HL
authors.lastname: Mansell
authors.forename: A
authors.initials: A
authors.lastname: Misra
authors.forename: N J T
authors.initials: NJ
authors.lastname: Monck
authors.forename: R M
authors.initials: RM
authors.lastname: Pratt
authors.forename: K
authors.initials: K
authors.lastname: Quirk
authors.forename: J R A
authors.initials: JR
authors.lastname: Roffey
authors.forename: S P
authors.initials: SP
authors.lastname: Vickers
authors.forename: I A
authors.initials: IA
authors.lastname: Cliffe
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
chemical_list: D019440:Anti-Obesity Agents; D007211:Indoles; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists; C057812:indoline