title: Human papillomaviruses and cancer in Uganda.
abstract: In a case-control study in Uganda, we examined associations between different cancer sites or types in relation to antibodies against human papillomaviruses (HPV)-16, -18 and -45. For each cancer site or type, the control group comprised all other cancers excluding those known, or thought to be associated with HPV infection (cancers of the uterine cervix, penis and eye). Among controls the seroprevalence of antibodies was 11% (68/616) against HPV-16, 5% (29/605) against HPV-18 and 6% (35/605) against HPV-45. Antibodies against HPV-16 were significantly associated with only two cancers: uterine cervix [prevalence of antibodies 27% (51/191); odds ratio (OR) 2.0, 95% confidence interval (CI) 1.2-3.1, P=0.01] and penis [prevalence of antibodies 27% (4/15); OR 6.4, 95% CI 1.7-24.3, P=0.01]. For both cancers, the risk increased with increasing anti-HPV-16 antibody titre (Ptrend=0.01 for each). No cancer site or type was significantly associated with antibodies against HPV-18 and -45.
authors.affiliation: Cancer Research UK, Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, UK. Rob.Newton@cancer.org.uk
authors.forename: R
authors.initials: R
authors.lastname: Newton
authors.forename: L
authors.initials: L
authors.lastname: Bousarghin
authors.forename: J
authors.initials: J
authors.lastname: Ziegler
authors.forename: D
authors.initials: D
authors.lastname: Casabonne
authors.forename: V
authors.initials: V
authors.lastname: Beral
authors.forename: E
authors.initials: E
authors.lastname: Mbidde
authors.forename: L
authors.initials: L
authors.lastname: Carpenter
authors.forename: D M
authors.initials: DM
authors.lastname: Parkin
authors.forename: H
authors.initials: H
authors.lastname: Wabinga
authors.forename: S
authors.initials: S
authors.lastname: Mbulaiteye
authors.forename: H
authors.initials: H
authors.lastname: Jaffe
authors.forename: A
authors.initials: A
authors.lastname: Touzé
authors.forename: P
authors.initials: P
authors.lastname: Coursaget
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D027383:Papillomaviridae / Q000145:classification / Q000276:immunology*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology; D010412:Penile Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000821:virology*; D016036:Seroepidemiologic Studies; D014454:Uganda / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral