title: NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.
abstract: Neurons and glia in the vertebrate central nervous system arise in temporally distinct, albeit overlapping, phases. Neurons are generated first followed by astrocytes and oligodendrocytes from common progenitor cells. Increasing evidence indicates that axon-derived signals spatiotemporally modulate oligodendrocyte maturation and myelin formation. Our previous observations demonstrate that F3/contactin is a functional ligand of Notch during oligodendrocyte maturation, revealing the existence of another group of Notch ligands. Here, we establish that NB-3, a member of the F3/contactin family, acts as a novel Notch ligand to participate in oligodendrocyte generation. NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Thus, the NB-3/Notch signaling pathway may prove to be a molecular handle to treat demyelinating diseases.
authors.affiliation: Department of Clinical Research and Group of Stem Cell Research, Singapore General Hospital, Singapore 169608.
authors.forename: Xiao-Ying
authors.initials: XY
authors.lastname: Cui
authors.forename: Qi-Dong
authors.initials: QD
authors.lastname: Hu
authors.forename: Meriem
authors.initials: M
authors.lastname: Tekaya
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shimoda
authors.forename: Beng-Ti
authors.initials: BT
authors.lastname: Ang
authors.forename: Du-Yu
authors.initials: DY
authors.lastname: Nie
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Hu
authors.forename: Meliha
authors.initials: M
authors.lastname: Karsak
authors.forename: Tanya
authors.initials: T
authors.lastname: Duka
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takeda
authors.forename: Lian-Yun
authors.initials: LY
authors.lastname: Ou
authors.forename: Gavin S
authors.initials: GS
authors.lastname: Dawe
authors.forename: Feng-Gang
authors.initials: FG
authors.lastname: Yu
authors.forename: Sohail
authors.initials: S
authors.lastname: Ahmed
authors.forename: Lian-Hong
authors.initials: LH
authors.lastname: Jin
authors.forename: Melitta
authors.initials: M
authors.lastname: Schachner
authors.forename: Kazutada
authors.initials: K
authors.lastname: Watanabe
authors.forename: Yvan
authors.initials: Y
authors.lastname: Arsenijevic
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Xiao
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D002454:Cell Differentiation; D002478:Cells, Cultured; D058966:Contactins; D051379:Mice; D008807:Mice, Inbred BALB C; D009474:Neurons / Q000166:cytology*; D009836:Oligodendroglia / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology*; D014157:Transcription Factors
chemical_list: D002352:Carrier Proteins; D015816:Cell Adhesion Molecules, Neuronal; C104189:Cntn6 protein, rat; D058966:Contactins; C497762:Notch1 protein, mouse; C497763:Notch1 protein, rat; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D014157:Transcription Factors; C409218:deltex protein, vertebrate