Virological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfection.
An HIV-1 infected man who experienced rapid disease progression and poor response to therapy after starting a new sexual relationship with an infected partner is known as the 'Ottawa superinfection case'. Subsequent analysis of viral sequences of protease, reverse transcriptase, Gag p17, and Env V3 provided no evidence for the acquisition of genetically divergent viruses before disease progression or drug resistance during virological failure of combination therapy. Whether HIV-1 superinfection contributes to disease progression or the spread of drug-resistant HIV-1 remains unknown.
Angel
Jonathan B
JB
Ottawa Health Research Institute and the Ottawa Hospital, University of Ottawa, Ottawa, Canada.
Hu
Yu-Wen
YW
Kravcik
Stephen
S
Tsui
Rose
R
Lee
Kok H
KH
Barbour
Jason
J
Balaskas
Evan
E
Branson
Bernard M
BM
Delwart
Eric L
EL
Grant
Robert M
RM
D023241:Antiretroviral Therapy, Highly Active; D018450:Disease Progression; D024882:Drug Resistance, Viral / Q000235:genetics; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D017421:Sequence Analysis; D012747:Sexual Partners; D015163:Superinfection / Q000821:virology*; D019562:Viral Load