Virus-induced neurobehavioral disorders: mechanisms and implications.
One hypothesis for the etiology of neuropsychiatric disorders proposes that viral infection contributes to the induction of neuronal system dysfunction, resulting in a wide range of behavioral abnormalities. Recent research in molecular biology supports this hypothesis and refocuses on the role of viral infection in the development of psychiatric disorders. Viral infection can induce deleterious effects in the central nervous system by direct and/or indirect pathways. Understanding the mechanisms of glial cell dysfunction caused by persistent viral infection should lead to novel insights into the development of neurobehavioral disorders, including human mental illnesses, and to the possible development of treatments.
Tomonaga
Keizo
K
Department of Virology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita Osaka 565-0871, Japan. tomonaga@biken.osaka-u.ac.jp
D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology / Q000473:pathology / Q000821:virology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D001523:Mental Disorders / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000821:virology*; D009422:Nervous System Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology / Q000821:virology*; D009457:Neuroglia / Q000276:immunology / Q000473:pathology / Q000821:virology; D009474:Neurons / Q000276:immunology / Q000473:pathology / Q000821:virology; D011323:Primates; D051381:Rats; D013570:Synaptic Membranes / Q000276:immunology / Q000473:pathology / Q000821:virology; D014777:Virus Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology; D014780:Viruses / Q000276:immunology / Q000472:pathogenicity
D016207:Cytokines