Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension.
Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. These observations suggest that Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis.
Nishino
Jinsuke
J
Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Yamada-oka, Suita, Osaka, Japan. jnishino@gen-info.osaka-u.ac.jp
Yamashita
Kimiyo
K
Hashiguchi
Hiromi
H
Fujii
Hideta
H
Shimazaki
Takuya
T
Hamada
Hiroshi
H
D000595:Amino Acid Sequence; D000818:Animals; D001369:Axons / Q000502:physiology*; D015152:Blotting, Northern; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D002478:Cells, Cultured; D017931:DNA Primers; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009420:Nervous System / Q000196:embryology*; D009457:Neuroglia / Q000378:metabolism* / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D013234:Stem Cells / Q000378:metabolism*
D017931:DNA Primers; D018076:DNA, Complementary; D036341:Intercellular Signaling Peptides and Proteins; C502097:METRN protein, human; D009419:Nerve Tissue Proteins; C502098:meteorin protein, mouse