title: Will containment of wild poliovirus in laboratories and inactivated poliovirus vaccine production sites be effective for global certification?
abstract: The absolute laboratory containment of any virus cannot be guaranteed, but a wealth of experience indicates that effective containment of wild poliovirus materials for global certification is technically and operationally feasible. Effective containment is based on the principles of minimal wild poliovirus infectious and potentially infectious materials in laboratories; minimal risks of operations in laboratories and inactivated poliovirus vaccine production facilities; minimal susceptibility of workers to wild poliovirus infection and shedding; and minimal susceptibility of populations to wild poliovirus spread. Each principle alone is imperfect, but collectively they greatly minimize the risks of transmitting wild poliovirus from the laboratory to the community.
authors.affiliation: World Health Organization, Geneva, Switzerland. wdowdle@taskforce.org
authors.forename: Walter R
authors.initials: WR
authors.lastname: Dowdle
authors.forename: Christopher
authors.initials: C
authors.lastname: Wolff
authors.forename: Raymond
authors.initials: R
authors.lastname: Sanders
authors.forename: Scott
authors.initials: S
authors.lastname: Lambert
authors.forename: Maureen
authors.initials: M
authors.lastname: Best
mesh_terms: D002568:Certification / Q000592:standards; D002648:Child; D004196:Disease Outbreaks / Q000517:prevention & control*; D015386:Hazardous Substances; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D007753:Laboratories / Q000592:standards; D007757:Laboratory Infection / Q000517:prevention & control*; D011051:Poliomyelitis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission / Q000821:virology; D017955:Poliovirus / Q000302:isolation & purification; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage*; D018570:Risk Assessment; D012307:Risk Factors; D017201:Virus Shedding; D014944:World Health Organization
chemical_list: D015386:Hazardous Substances; D011054:Poliovirus Vaccine, Inactivated