The special structure and function of troponin I in regulation of cardiac contraction and relaxation.
In this chapter I review evidence for a pivotal role of the sarcomeric thin filament protein, troponin I, in cardiac muscle activation and its modulation by covalent modifications, sarcomere length, and intracellular pH. This evidence demonstrates that the cardiac variant of troponin I (cTnI), which is the only isoform expressed in the adult myocardium, has unique structure and function that are specialized for extrinsic and intrinsic control of cardiac contraction and relaxation.
Solaro
R John
RJ
Department of Physiology and Biophysics (M/C 901), University of Illinois at Chicago, College of Medicine, Chicago, IL 60612, USA.
D000138:Acidosis; D008841:Actin Cytoskeleton / Q000737:chemistry; D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D004285:Dogs; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008958:Models, Molecular; D009119:Muscle Contraction; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D020033:Protein Isoforms; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D012518:Sarcomeres / Q000378:metabolism; D015398:Signal Transduction; D019210:Troponin I / Q000737:chemistry*
D020033:Protein Isoforms; D019210:Troponin I; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C