title: Malaria sporozoite: migrating for a living.
abstract: Plasmodium sporozoite invasion of host hepatocytes is an initial key step in infection by malaria parasite. Sporozoites can enter hepatocytes via two distinct pathways: by disruption of the plasma membrane followed by parasite migration through cells, or by the formation of a vacuole essential for further differentiation of the parasite. For Plasmodium falciparum, this differentiation requires the presence of CD81 on the hepatocyte surface. Recent findings with rodent parasites also suggest that migration through cells has an effect on both the sporozoite infectivity and the permissiveness of surrounding cells.
authors.affiliation: Inserm U511, Immunobiologie Cellulaire et Moléculaire des Infections Parasataires, Centre Hospitalo-Universitaire Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France. silvie@ext.jussieu.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Silvie
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Franetich
authors.forename: Luarent
authors.initials: L
authors.lastname: Rénia
authors.forename: Dominique
authors.initials: D
authors.lastname: Mazier
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002465:Cell Movement; D022781:Hepatocytes / Q000469:parasitology*; D006801:Humans; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000469:parasitology*; D010961:Plasmodium / Q000254:growth & development / Q000472:pathogenicity*; D034101:Sporozoites / Q000502:physiology; D060225:Tetraspanin 28
chemical_list: D015703:Antigens, CD; C554798:CD81 protein, human; D060225:Tetraspanin 28