title: MR volumetric analysis of the course of nephroblastomatosis under chemotherapy in childhood.
abstract: Nephroblastomatosis is a paediatric renal disease that may undergo malignant transformation. When neoadjuvant chemotherapy is indicated for nephroblastomatosis or bilateral Wilms' tumours, exact volumetric analysis using high-speed data processing and visualization may aid in determining tumour response. Using 3D-volume-rendering software, the 0.5-T MRI data of a 2-year-old girl with bilateral nephroblastomatosis was analysed. Exact volume determination of foci of nephroblastomatosis was performed by automatic and manual segmentation, and the relation to normal renal parenchyma was determined over a 12-month period. At the first visit, 80% (460/547 ml) of the extremely enlarged right kidney was due to nephroblastomatosis. Total tumour volume within the right kidney decreased to 74 ml under chemotherapy. Volume analysis of the two emerging right-sided masses after treatment correctly suggested Wilms' tumour. Three-dimensional rendering of the growing masses aided the surgeon in nephron-sparing surgery during tumour resection.
authors.affiliation: Department of Paediatric Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. Patrick_Guenther@med.uni-heidelberg.de
authors.forename: Patrick
authors.initials: P
authors.lastname: Günther
authors.forename: Jochen
authors.initials: J
authors.lastname: Tröger
authors.forename: Norbert
authors.initials: N
authors.lastname: Graf
authors.forename: Karl Ludwig
authors.initials: KL
authors.lastname: Waag
authors.forename: Jens-Peter
authors.initials: JP
authors.lastname: Schenk
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D012074:Remission Induction; D016896:Treatment Outcome; D009396:Wilms Tumor / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery