The synthesis and antibacterial activity of 3-alkyl derivatives of some pyrimido[4,5-d] pyrimidine.
The synthesis of 4,5-diamino derivatives of pyrimidine and pyrimido[4,5-d]pyrimidines is presented. The antibacterial and antifungal activity of the compounds was investigated on nine selected bacterial species, comparing the changes in the chemical structure with increase in the bioactive properties. The investigations have shown that the obtained derivatives of pyrimido[4,5-d]pyrimidines and especially the compounds reveal interesting antibacterial 6e and antifungal 6d activity.
Cieplik
Jerzy
J
Department of Organic Chemistry, Medical Academy, 9 Grodzka Str., 50-137 Wrocław, Poland.
Pluta
Janusz
J
Gubrynowicz
Olaf
O
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D011744:Pyrimidinones