title: Solid-phase syntheses of furopyridine and furoquinoline systems.
abstract: [reaction: see text] Syntheses of 2-substituted furo[3,2-b]pyridines and furo[3,2-h]quinolines have been achieved for the first time in the solid-phase mode. The central enabling steps involved concomitant deprotection/cyclization promoted by the mild base K(2)CO(3). Reactions were monitored "in situ" in real time by a variety of spectroscopic techniques, which allowed full and accurate control of progress in these syntheses.
authors.affiliation: Biomedical Research Institute, Barcelona Scientific Park, Laboratory of Organic Chemistry, Faculty of Pharmacy, and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Cironi
authors.forename: Judit
authors.initials: J
authors.lastname: Tulla-Puche
authors.forename: George
authors.initials: G
authors.lastname: Barany
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Mercedes
authors.initials: M
authors.lastname: Alvarez
mesh_terms: D008968:Molecular Conformation; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011725:Pyridines; D011804:Quinolines