title: Bone lesion detection with carrier-added 99mTc-EDTMP in comparison with 99mTc-DPD.
abstract: An increased uptake of bone-seeking radiopharmaceuticals into malignant bone lesions could further improve the diagnostic accuracy of routine bone scanning. The tracers used in clinical routine for bone scanning are methylene-diphosphonate (MDP), dicarboxypropane-diphosphonate (DPD) and ethylenediaminetetramethylene-phosphonate (EDTMP). MDP and DPD are usually labelled with 99mTc for diagnostic use, whereas EDTMP is labelled with 153Sm for therapeutic purposes. This study aimed to compare, for the first time, bone scanning with an improved preparation of 99mTc-EDTMP (by the addition of rhenium) (carrier-added) with 99mTc-DPD. Twenty malignant bone lesions were investigated in 10 patients. The ratios of bone lesion to soft tissue (BL/ST) and of bone lesion to normal bone (BL/NB) were compared 3 h after the injection of either compound. Quantitative analysis demonstrated a significant (P<0.05) difference in BL/ST ratio in favour of 99mTc-DPD. The BL/NB ratio was not significantly different. Visual image analysis resulted in a clinically comparable interpretation of imaging studies with the use of 99mTc-DPD and carrier-added 99mTc-EDTMP. These preliminary data support the concept of carrier addition to increase bone uptake by the modification of the complex structure of 99mTc-EDTMP. However, any advantage over conventional 99mTc-based tracers for bone scintigraphy in clinical use needs to be demonstrated in controlled trials.
authors.affiliation: Department of Nuclear Medicine, University of Vienna, Vienna, Austria. bfueger@mednet.ucla.edu
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Fueger
authors.forename: Markus
authors.initials: M
authors.lastname: Mitterhauser
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Wadsak
authors.forename: Sedat
authors.initials: S
authors.lastname: Ofluoglu
authors.forename: Tatjana
authors.initials: T
authors.lastname: Traub
authors.forename: Georgios
authors.initials: G
authors.lastname: Karanikas
authors.forename: Robert
authors.initials: R
authors.lastname: Dudczak
authors.forename: Christian
authors.initials: C
authors.lastname: Pirich
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001847:Bone Diseases / Q000175:diagnosis; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology; D002986:Clinical Trials as Topic; D004164:Diphosphonates; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011471:Prostatic Neoplasms / Q000473:pathology; D011786:Quality Control; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013997:Time Factors
chemical_list: D004164:Diphosphonates; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid; C475628:technetium Tc 99m ethylenediamine-tetramethylenephosphonic acid