title: Ontogeny of Langerin/CD207 expression in the epidermis of mice.
abstract: C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules. We studied the emergence of Langerin expression in LC in epidermal sheets and cell suspensions during ontogeny. Langerin appears later than MHC II expression. Intracellular Langerin expression becomes apparent 2-3 d after birth. Only 10 days after birth all LC co-express Langerin. The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules.
authors.affiliation: Department of Dermatology, University of Innsbruck, Innsbruck, Austria.
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Tripp
authors.forename: Souyet
authors.initials: S
authors.lastname: Chang-Rodriguez
authors.forename: Patrizia
authors.initials: P
authors.lastname: Stoitzner
authors.forename: Sandra
authors.initials: S
authors.lastname: Holzmann
authors.forename: Hella
authors.initials: H
authors.lastname: Stössel
authors.forename: Patrice
authors.initials: P
authors.lastname: Douillard
authors.forename: Sem
authors.initials: S
authors.lastname: Saeland
authors.forename: Franz
authors.initials: F
authors.lastname: Koch
authors.forename: Adelheid
authors.initials: A
authors.lastname: Elbe-Bürger
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Romani
mesh_terms: D000367:Age Factors; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D004817:Epidermis / Q000737:chemistry*; D005434:Flow Cytometry; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007801:Langerhans Cells / Q000737:chemistry*; D037181:Lectins, C-Type / Q000032:analysis*; D037241:Mannose-Binding Lectins / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000954:Antigens, Surface; C498497:Cd207 protein, mouse; D000949:Histocompatibility Antigens Class II; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins