title: New biologically active triterpenoid saponins from Scabiosa tschiliensis.
abstract: Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7, 9), hookerosides A, B (12, 13), and prosapogenin 1b all exhibited strong inhibition of pancreatic lipase in vitro.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Quan
authors.initials: Q
authors.lastname: Zheng
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Li-Kun
authors.initials: LK
authors.lastname: Han
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Okuda
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Nikaido
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008049:Lipase / Q000037:antagonists & inhibitors*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000494:pharmacology; D010179:Pancreas / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D012503:Saponins; D014315:Triterpenes; C485169:hookeroside A; C485170:hookeroside B; D009828:Oleanolic Acid; D008049:Lipase