Antiviral flavonoids from the seeds of Aesculus chinensis.
A bioassay-guided fractionation of an ethanol extract of the seeds of Aesculus chinensis led to the isolation of two new flavanoids (1 and 2), along with eight known ones (3-10). The structures of the new compounds were elucidated by spectroscopic methods including 2D NMR. All compounds were tested for antiviral activity against respiratory syncytial virus (RSV), parainfluenza virus type 3 (PIV 3), and influenza virus type A (Flu A). Compounds 1, 2, and 6 showed significant antiviral activities against RSV with IC(50) values of 4.5, 6.7, and 4.1 microg/mL and selective index (SI) values of 15.8, 32, and 63.8, respectively. Compound 8 demonstrated significant antiviral activity against Flu A with an IC(50) of 24.5 microg/mL and a SI of 16.0, respectively.
Wei
Feng
F
National Institute for the Control of Pharmaceutical and Biological Products, State Food and Drug Administration, Beijing 100050, People's Republic of China.
Ma
Shuang-Cheng
SC
Ma
Lin-Yun
LY
But
Paul Pui-Hay
PP
Lin
Rui-Chao
RC
Khan
Ikhlas A
IA
D031319:Aesculus / Q000737:chemistry*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009980:Influenza A virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D000998:Antiviral Agents; D005419:Flavonoids; C485174:aescuflavoside; C485175:aescuflavoside A