title: Differential expression levels of MRP1, MRP4, and MRP5 in response to human immunodeficiency virus infection in human macrophages.
abstract: Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.
authors.affiliation: CEA, Service de Neurovirologie, Université Paris XI, CRSSA, EPHE, IPS, Fontenay-aux-Roses, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Jorajuria
authors.forename: Nathalie
authors.initials: N
authors.lastname: Dereuddre-Bosquet
authors.forename: Karen
authors.initials: K
authors.lastname: Naissant-Storck
authors.forename: Dominique
authors.initials: D
authors.lastname: Dormont
authors.forename: Pascal
authors.initials: P
authors.lastname: Clayette
mesh_terms: D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / Q000378:metabolism; D015658:HIV Infections / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000096:biosynthesis; D008264:Macrophages / Q000378:metabolism*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012269:Ribosomal Proteins / Q000096:biosynthesis*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D024601:Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); D015850:Interleukin-6; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D012333:RNA, Messenger; D012269:Ribosomal Proteins; D014409:Tumor Necrosis Factor-alpha; C073492:ABCC4 protein, human; C120809:ABCC5 protein, human; C421109:multidrug resistance-associated protein 1