Increased serum concentrations of monokine induced by interferon-gamma/CXCL9 and interferon-gamma-inducible protein 10/CXCL-10 in Sydenham's chorea patients.
Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-gamma (Mig), and CXCL10, formerly interferon-gamma-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis.
Teixeira
Antonio L
AL
Movement Disorders Clinic, Faculty of Medicine, Federal University of Minas Gerais, Brazil.
Cardoso
Francisco
F
Souza
Adriano L S
AL
Teixeira
Mauro M
MM
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D019743:Chemokines, CXC / Q000097:blood* / Q000134:cerebrospinal fluid; D002648:Child; D002819:Chorea / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000134:cerebrospinal fluid; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D015854:Up-Regulation / Q000276:immunology
C080810:CXCL9 protein, human; D054357:Chemokine CXCL10; D054370:Chemokine CXCL9; D019743:Chemokines, CXC; D018836:Inflammation Mediators; D036341:Intercellular Signaling Peptides and Proteins