Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2.
Mice depleted of gammadelta T cells by in vivo administration of anti-TCRgammadelta monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the gammadelta T-cell-depleted mice. Mice deficient in the Vdelta1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial gammadelta T cells bearing Vdelta1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.
Nishimura
Hitoshi
H
Division of Host Defense, Medical Institute for Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Yajima
Toshiki
T
Kagimoto
Yoshiko
Y
Ohata
Mutsuhiro
M
Watase
Taketo
T
Kishihara
Kenji
K
Goshima
Fumi
F
Nishiyama
Yukihiro
Y
Yoshikai
Yasunobu
Y
D000818:Animals; D004848:Epithelium / Q000276:immunology*; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology* / Q000821:virology; D018258:Herpesvirus 2, Human / Q000276:immunology*; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014599:Uterus / Q000276:immunology / Q000821:virology; D014621:Vagina / Q000276:immunology / Q000821:virology
D016692:Receptors, Antigen, T-Cell, gamma-delta