title: A role for fast rhythmic bursting neurons in cortical gamma oscillations in vitro.
abstract: Basic cellular and network mechanisms underlying gamma frequency oscillations (30-80 Hz) have been well characterized in the hippocampus and associated structures. In these regions, gamma rhythms are seen as an emergent property of networks of principal cells and fast-spiking interneurons. In contrast, in the neocortex a number of elegant studies have shown that specific types of principal neuron exist that are capable of generating powerful gamma frequency outputs on the basis of their intrinsic conductances alone. These fast rhythmic bursting (FRB) neurons (sometimes referred to as "chattering" cells) are activated by sensory stimuli and generate multiple action potentials per gamma period. Here, we demonstrate that FRB neurons may function by providing a large-scale input to an axon plexus consisting of gap-junctionally connected axons from both FRB neurons and their anatomically similar counterparts regular spiking neurons. The resulting network gamma oscillation shares all of the properties of gamma oscillations generated in the hippocampus but with the additional critical dependence on multiple spiking in FRB cells.
authors.affiliation: School of Biomedical Sciences, The Worsley Building, University of Leeds, Leeds LS2 9JT, United Kingdom.
authors.forename: Mark O
authors.initials: MO
authors.lastname: Cunningham
authors.forename: Miles A
authors.initials: MA
authors.lastname: Whittington
authors.forename: Andrea
authors.initials: A
authors.lastname: Bibbig
authors.forename: Anita
authors.initials: A
authors.lastname: Roopun
authors.forename: Fiona E N
authors.initials: FE
authors.lastname: LeBeau
authors.forename: Angelika
authors.initials: A
authors.lastname: Vogt
authors.forename: Hannah
authors.initials: H
authors.lastname: Monyer
authors.forename: Eberhard H
authors.initials: EH
authors.lastname: Buhl
authors.forename: Roger D
authors.initials: RD
authors.lastname: Traub
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001303:Auditory Cortex / Q000187:drug effects / Q000378:metabolism*; D004569:Electroencephalography; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D010672:Phenytoin / Q000494:pharmacology; D051381:Rats
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin