Dopaminergic hypersensitivity in patients with Parkinson disease and migraine.
Because migraine has been associated with dopaminergic receptor hypersensitivity, the authors hypothesized that patients with Parkinson disease with current or prior migraine have better dopaminergic response and less motor disability than Parkinson disease patients without migraine. Twenty-eight patients with Parkinson disease were included and matched (10 patients with migraine and 18 patients without migraine). Patients with Parkinson disease and migraine showed greater motor improvement during the ON state than patients without migraine with the same medication exposure. These data support the hypothesis that migraine may be associated with dopaminergic hypersensitivity.
Cubo
Esther
E
Sanatorio del Rosario, Clinica de la Zarzuela, Department of Neurology, Madrid, Spain. ecubo@inicia.es
Kompoliti
Katie
K
Leurgans
Sue E
SE
Raman
Rema
R
D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004298:Dopamine / Q000502:physiology*; D018491:Dopamine Agonists / Q000009:adverse effects / Q000627:therapeutic use*; D020820:Dyskinesias / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D009043:Motor Activity / Q000187:drug effects; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D012720:Severity of Illness Index; D016037:Single-Blind Method
D000978:Antiparkinson Agents; D018491:Dopamine Agonists; D007980:Levodopa; D004298:Dopamine