Vatairea macrocarpa lectin induces paw edema with leukocyte infiltration.
A lectin from Vatairea macrocarpa (Vmac) seeds was investigated in a model of paw edema in rats and the possible involvement of leukocytes. Vmac (200 and 400 microg/paw, s.c.) induced a significant time- and dose-dependent paw edema, with leukocyte infiltration, which was drastically reduced in leukopaenic animals. These data suggest a pro-inflammatory effect for this lectin that is dependent on the presence of leukocytes.
Alencar
Nylane M N
NM
Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Cel Nunes de Melo 1127, CEP 60430-270 Fortaleza-CE Brasil. nylanenunes@hotmail.com
Assreuy
Ana M S
AM
Criddle
David N
DN
Souza
Emmanuel P
EP
Soares
Pedro M G
PM
Havt
Alexandre
A
Aragão
Karoline S
KS
Bezerra
Daniel P
DP
Ribeiro
Ronaldo A
RA
Cavada
Benildo S
BS
D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D004487:Edema / Q000139:chemically induced* / Q000473:pathology; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D006614:Hindlimb / Q000473:pathology; D007279:Injections, Subcutaneous; D007962:Leukocytes / Q000187:drug effects / Q000473:pathology; D037121:Plant Lectins / Q000302:isolation & purification* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000033:anatomy & histology / Q000737:chemistry
D037121:Plant Lectins