title: [Relationship between six single nucleotide polymorphisms of angiotensinogen gene and essential hypertension].
abstract: OBJECTIVE
  To evaluate the relationship of six single nucleotide polymorphisms(SNPs) and their haplotypes of angiotensinogen(AGT) gene to essential hypertension(EH) in Chinese Han population.
  
  
  METHODS
  The genotypes in 185 patients with EH and 185 healthy controls were determined by the method of ABI PRISM SNaPshot Multiplex Kit using six AGT gene polymorphisms at position -217(G/A), -152(G/A), -20(A/C) and -6(G/A) in the promoter region and T174M, M235T in exon 2.
  
  
  RESULTS
  The distribution of AGT genotypes and alleles frequencies showed no significant difference between the group of EH and group of controls (P>0.05). However, haplotype analysis revealed that H4 haplotype frequency, which included -152A, -20C, -6A and 235T alleles, was significantly increased in the group of EH (P<0.05).
  
  
  CONCLUSIONS
  G-152A, A-20C, G-6A and M235T polymorphisms of AGT gene might play an important role in the occurrence of EH in Chinese Han population.
authors.affiliation: Department of Cardiology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025 PR China. liuliuyanyan@etang.com
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Zheng-wen
authors.initials: ZW
authors.lastname: Jiang
authors.forename: Kui-xing
authors.initials: KX
authors.lastname: Zhang
authors.forename: Hai-hui
authors.initials: HH
authors.lastname: Sheng
authors.forename: Lin
authors.initials: L
authors.lastname: Jin
authors.forename: Ya-yun
authors.initials: YY
authors.lastname: Sheng
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Jin-de
authors.initials: JD
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000808:Angiotensinogen / Q000097:blood / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D000808:Angiotensinogen