title: Snake venom thrombin-like enzymes: from reptilase to now.
abstract: The snake venom thrombin-like enzymes (SVTLEs) comprise a number of serine proteases functionally and structurally related to thrombin. Until recently, only nine complete sequences of this subgroup of the serine protease family were known. Over the past 5 years, the primary structure of several SVTLEs has been characterized, and now this family includes several members. Of particular interest is their possible use in pathologies such as thrombosis. The aim of the present review is to summarize the state of the art concerning the evolutionary, structural and biological features of the SVTLEs.
authors.affiliation: Departamento de Biologia Celular e Molecular, IB-CEG, Universidade Federal Fluminense, Niterói, 24001-970 Rio de Janeiro, Brazil. hcastrorangel@vm.uff.br
authors.forename: H C
authors.initials: HC
authors.lastname: Castro
authors.forename: R B
authors.initials: RB
authors.lastname: Zingali
authors.forename: M G
authors.initials: MG
authors.lastname: Albuquerque
authors.forename: M
authors.initials: M
authors.lastname: Pujol-Luz
authors.forename: C R
authors.initials: CR
authors.lastname: Rodrigues
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D012103:Batroxobin / Q000737:chemistry / Q000145:classification / Q000502:physiology / Q000627:therapeutic use; D001665:Binding Sites; D020134:Catalytic Domain; D004791:Enzyme Inhibitors / Q000378:metabolism; D006490:Hemostatics / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016415:Sequence Alignment; D012697:Serine Endopeptidases / Q000737:chemistry / Q000145:classification / Q000502:physiology / Q000627:therapeutic use; D012910:Snake Venoms / Q000737:chemistry*; D013917:Thrombin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D006490:Hemostatics; D012910:Snake Venoms; D012103:Batroxobin; D012697:Serine Endopeptidases; D013917:Thrombin