Ethological analysis of the effects of fluoglyzine on mice exposed to chronic social stress.
Ethological study of a new agent fluoglyzine (fluoxetine analog) was carried out. Porsolt test revealed a positive antidepressant effect of fluoglyzine in mice with pronounced depression-like state. This effect was more pronounced than the effect of fluoxetine. Both drugs effectively improved communicative activity of experimental animals. Anxiety tests showed no anxiolytic effects of fluoglyzine and fluoxetine.
Avgustinovich
D F
DF
Sector of Social Behavior Neurogenetics, Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk.
Kovalenko
I L
IL
Sorokina
I V
IV
Tolstikova
T G
TG
Tolstikov
A G
AG
D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D005010:Ethology; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013315:Stress, Psychological / Q000188:drug therapy*
D000928:Antidepressive Agents; C497520:fluoglyzine; D005473:Fluoxetine