[Regulating effect of gamma-aminobutyric acid and pyrrolidone-2 on endogenous blood metalloproteins with anti- and pro-oxidant activity in hypoxia].
Various stages of hypokinesia are marked by specific changes in the level and activity of endogenous metalloproteins with anti- (MAA) and prooxidant action (MPA). In particular, the level of MPA [cytochromes b5 and b558 (III + IV) and suprol] decreases in all stages (except for the level of cytochrome b5 exceeding that in the free control on the 15th and 30th day of hypokinesia). The superoxide production activity of suprol always exceeds that in the control, while the activity of cytochrome b558 (III) exceeds that in the control only on the 30th day of experiment. The level and activity of MAA [ceruloplasmin, transferrin (TF), superoxide dismutase (SOD), and catalase] decrease with the duration of hypokinesia (except for 15th day, when the level of TF and the activity of SOD exceed the values in the free control group). The administration of GABA and pyrrolidone decreases the extent of oxidative stress, which is manifested by leveling of the MAA and MPA content and activity.
Manukian
A A
AA
Department of Pharmacology, Yerevan State Medical University, ul. Koryuna 2, Erevan, 375025 Armenia.
Simonian
M A
MA
Simonian
R M
RM
Simonian
G M
GM
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D018476:Hypokinesia / Q000378:metabolism*; D008297:Male; D008667:Metalloproteins / Q000378:metabolism*; D018384:Oxidative Stress; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000975:Antioxidants; D008667:Metalloproteins; D011760:Pyrrolidinones; D017382:Reactive Oxygen Species; D005680:gamma-Aminobutyric Acid; C028537:2-pyrrolidone