title: Relationship of body mass index and prostate specific antigen in a population-based study.
abstract: This study was designed to use a prospectively analyzed, population-based, multiethnic cohort of men to determine if there is a relationship between one measure of obesity/overweight (Body Mass Index) and Prostate Specific Antigen (PSA). A total of 1565 men without a prior diagnosis of prostate cancer were prospectively enrolled in the San Antonio study of Biomarkers Of Risk (SABOR) Clinical and Epidemiologic Center of the Early Detection Research Network of the National Cancer Institute. Body Mass Index (BMI) was compared with serum PSA levels, stratifying by ethnic group. No relationship was found between BMI and PSA in any ethnic group or in the cohort as a whole. This study suggests that there is no increased risk of overdetection of prostate cancer among obese men due to an elevation in PSA.
authors.affiliation: Departments of Surgery and Pathology and Cellular and Structural Biology, University of Texas HSC at San Antonio, The San Antonio Center for Biomarkers of Risk of Prostate Cancer (SABOR), San Antonio Cancer Institute, TX 78229, USA. thompsoni@uthscsa.edu
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
authors.forename: Robin
authors.initials: R
authors.lastname: Leach
authors.forename: Dean
authors.initials: D
authors.lastname: Troyer
authors.forename: Brad
authors.initials: B
authors.lastname: Pollock
authors.forename: Susan
authors.initials: S
authors.lastname: Naylor
authors.forename: Betsy
authors.initials: B
authors.lastname: Higgins
mesh_terms: D015992:Body Mass Index; D005828:Genetics, Population; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000592:standards; D009765:Obesity / Q000097:blood* / Q000473:pathology; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen