[Epidemiology of lip-maxilla-palate clefts in the canton of Vaud].
Epidemiological variables in oral clefts were examined in a cohort of patients with congenital malformations from the canton of Vaud in Switzerland during the years 1990-1999. Among 77'259 newborns or foetuses, 144 cases of oral clefts were identified in the Registre Vaudois des Anomalies Congénitales (RVAC), yielding a total prevalence of 18.6 per 10'000. These clefts consisted of 84 (58%) cases of cleft lip with or without cleft palate (CL/P) and 60 (42%) cases of cleft palate only (CP). Associated anomalies were found in 45% of cases. Our results are compared with previous reports in other parts of Europe.
Addor
Marie-Claude
MC
Service de Génétique Médicale, CHUV, Lausanne.
Feldmeyer
Laurence
L
Hohlfeld
Judith
J
Schorderet
Daniel F
DF
D000015:Abnormalities, Multiple / Q000453:epidemiology; D002971:Cleft Lip / Q000175:diagnosis / Q000453:epidemiology*; D002972:Cleft Palate / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008437:Maxilla / Q000002:abnormalities*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D015995:Prevalence; D012042:Registries; D017678:Sex Distribution; D013557:Switzerland / Q000453:epidemiology