title: Preserved episodic memory in subcortical band heterotopia.
abstract: OBJECTIVE
  Neuropsychological profiles of four patients with subcortical band heterotopia (SBH) are presented to delineate further the phenotype of this disorder.
  
  
  METHODS
  Standardized, norm-referenced measures of cognitive functioning, including intelligence, processing speed, attention, language, visuomotor skills, memory, and fine motor ability were administered to four patients with magnetic resonance imaging evidence of SBH.
  
  
  RESULTS
  Despite intellectual impairment and other severe cognitive deficits, all four patients displayed relatively intact episodic memory.
  
  
  CONCLUSIONS
  This selective sparing of memory functions has not been previously reported in individuals with SBH and suggests that doublecortin does not play a role in the development of memory systems in the mesial temporal region, which tend to be spared in SBH.
authors.affiliation: Department of Clinical Neurosciences, London Health Sciences Center, London, Ontario, Canada. Laura.Janzen@lhsc.on.ca
authors.forename: Laura
authors.initials: L
authors.lastname: Janzen
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Sherman
authors.forename: John
authors.initials: J
authors.lastname: Langfitt
authors.forename: Michel
authors.initials: M
authors.lastname: Berg
authors.forename: Mary
authors.initials: M
authors.lastname: Connolly
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000002:abnormalities*; D002648:Child; D003072:Cognition Disorders / Q000175:diagnosis / Q000503:physiopathology / Q000523:psychology; D000089622:Doublecortin Domain Proteins; D004569:Electroencephalography / Q000706:statistics & numerical data; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000523:psychology; D004827:Epilepsy / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000523:psychology; D008869:Microtubule-Associated Proteins; D009421:Nervous System Malformations / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D009479:Neuropeptides / Q000235:genetics; D009483:Neuropsychological Tests; D013702:Temporal Lobe / Q000503:physiopathology; D014888:Wechsler Scales
chemical_list: D000089622:Doublecortin Domain Proteins; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides