Bradycardia during therapy for multiple myeloma with thalidomide.
We studied the medical records of 96 patients who received thalidomide and 104 patients who made up a control group. We found that 53% of patients (52 patients) using thalidomide had a heart rate of <60 beats/min at some point during follow-up and 19% of thalidomide patients (10 patients) developed symptom-related bradycardia. Reducing the thalidomide dose appeared to alleviate symptoms in most patients.
Fahdi
Ibrahim Elias
IE
Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Gaddam
Venkat
V
Saucedo
Jorge F
JF
Kishan
Channarayapatna V
CV
Vyas
Keyur
K
Deneke
Matthew G
MG
Razek
Hani
H
Thorn
Brett
B
Bissett
Joseph K
JK
Anaissie
Elias J
EJ
Anaisse
Elias
E
Barlogie
Bart
B
Mehta
Jawahar L
JL
D001919:Bradycardia / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D009101:Multiple Myeloma / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D013792:Thalidomide