Disease severity in siblings with cystic fibrosis.
Since cross-infection occurs between cystic fibrosis (CF) siblings, we hypothesized that subsequent siblings may acquire respiratory pathogens at an earlier age and have a more severe course of pulmonary disease. We studied a retrospective cohort of 31 sibling pairs from the CF database at the Hospital for Sick Children. Kaplan-Meier curves and modified log-rank tests were used to test sibling differences in age of acquisition of Pseudomonas aeruginosa (PA), Staphylococcus aureus (SA), or any positive culture. Differences in disease severity outcomes were explored. Older siblings were more likely to have both SA and any CF pathogen first isolated from respiratory culture at an older age than younger siblings (P = 0.0050 and P = 0.0008, respectively, by modified log-rank tests). However, more of the older siblings were positive on first culture at time of diagnosis, introducing an age-of-diagnosis bias. Hospitalization rates, courses of oral antibiotics, FEV(1) % predicted, and weight and height measurements were not better in the older children. No differences in clinical parameters were found between older and younger siblings. The apparent finding of younger age at first isolation of pathogens from respiratory cultures in younger siblings is likely because many older siblings were already infected with these organisms at time of diagnosis.
Katz
Sherri L
SL
Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
Strug
Lisa J
LJ
Coates
Allan L
AL
Corey
Mary
M
D017668:Age of Onset; D001722:Birth Order; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D017063:Outcome Assessment, Health Care; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000235:genetics; D035781:Siblings; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000235:genetics