title: A novel synthesis of amino-1,2-oxazinones as a versatile synthon for beta-amino acid derivatives.
abstract: The radical addition-cyclisation of alpha, beta-unsaturated hydroxamates containing an oxime ether provides a novel method for the stereoselective synthesis of amino-1,2-oxazinones. Its synthetic utility is demonstrated by a stereoselective synthesis of beta-amino acid derivatives, such as alpha-alkyl-beta-amino-gamma-lactone and alpha,beta-disubstituted beta-lactam.
authors.affiliation: Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Okiko
authors.initials: O
authors.lastname: Miyata
authors.forename: Megumi
authors.initials: M
authors.lastname: Namba
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.forename: Takeaki
authors.initials: T
authors.lastname: Naito
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D010078:Oxazines