title: Semecarpus anacardium L, nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property.
abstract: Traditionally S. anacardium is used for rejuvenation, rheumatoid arthritis, fever and neurological disorders. In the present study it was observed that a fraction of S. anacacrdium at dose of 1 mg/100 g body wt, significantly reduced serum cholesterol from 378.87 mg/dl in the rats fed with atherogenic diet (AD) to 197.99 mg/dl (45-52%) in the rats fed with AD diet and increased serum HDL-cholesterol (33-37%). The same fraction also inhibited LPS induced NO production in the culture activated rat peritoneal macrophages in the dose dependent manner with IC50 value at 50 ng/ml of the culture medium. The drug in the above doses was completely safe and non-toxic, (no change in the enzymes), to liver and kidney functions.
authors.affiliation: Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India. yamini30@sify.com
authors.forename: Y B
authors.initials: YB
authors.lastname: Tripathi
authors.forename: R S
authors.initials: RS
authors.lastname: Pandey
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000378:metabolism; D004036:Diet, Atherogenic; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008111:Liver Function Tests; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D009754:Nuts; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D031023:Semecarpus / Q000737:chemistry*
chemical_list: D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D008070:Lipopolysaccharides; D010936:Plant Extracts; D009569:Nitric Oxide; D002784:Cholesterol