title: Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica.
abstract: Eight furanocoumarins, one coumarin and four acridone derivatives have been identified in the roots of Thamnosma rhodesica (Rutaceae). Rhodesiacridone, one of these acridone derivatives, is reported here for the first time. Its structure was elucidated by spectrometric methods including ESI-HR, EI, DCI mass spectrometry, 1H, 13C and 2D NMR experiments. This novel compound showed activities against the intracellular form of a human pathogen, the protozoan parasite Leishmania major. Two known acridone related compounds, gravacridonediol and 1-hydroxy-10-methylacridone, exhibited activities against the intracellular form of the same parasite and the fungus Cladosporium cucumerinum, respectively.
authors.affiliation: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland.
authors.forename: Kouassi Maximin
authors.initials: KM
authors.lastname: Ahua
authors.forename: Jean-Robert
authors.initials: JR
authors.lastname: Ioset
authors.forename: Adriana
authors.initials: A
authors.lastname: Ransijn
authors.forename: Jacques
authors.initials: J
authors.lastname: Mauël
authors.forename: Steven
authors.initials: S
authors.lastname: Mavi
authors.forename: Kurt
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000166:Acridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D054831:Acridones; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002963:Cladosporium / Q000187:drug effects; D006801:Humans; D018320:Leishmania major / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009761:Nystatin / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000166:Acridines; D054831:Acridones; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D009761:Nystatin; C041300:acridone; D000666:Amphotericin B