title: ADRIS - The Adverse Drug Reactions Information Scheme.
abstract: Under the Adverse Drug Reactions Information Scheme (ADRIS) data and knowledge relevant to the etiology of adverse drug reactions (ADRs) such as chemical structure of parent compounds, metabolites, covalent adducts, nucleic acid and protein sequences, protein structures, pharmaco-, toxico- and enzyme kinetics, pharmaco- and toxicodynamics, protein interactions, molecular pathways and complexes, as well as toxicological and clinical outcomes, are collected and logically and semantically related. ADRIS reflects the ontological prerequisite for the creation of databases and knowledge discovery systems for the abstraction and visualization of theragenomic concepts. A final outcome is the prediction of ADRs based on a profound knowledge of drug function and the molecular basics for personalized drug safety and eventually, personalized medicine. 2004
authors.affiliation: TheraSTrat AG, Gewerbestrasse 25, 4123 Allschwil, Switzerland.
authors.forename: Hubert
authors.initials: H
authors.lastname: Hug
authors.forename: Dario
authors.initials: D
authors.lastname: Bagatto
authors.forename: Robert
authors.initials: R
authors.lastname: Dannecker
authors.forename: Richard
authors.initials: R
authors.lastname: Schindler
authors.forename: Oliver
authors.initials: O
authors.lastname: Horlacher
authors.forename: Joseph
authors.initials: J
authors.lastname: Gut
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D001189:Aryl Hydrocarbon Hydroxylases / Q000737:chemistry / Q000378:metabolism; D065729:Cytochrome P-450 CYP2C9; D003628:Database Management Systems / Q000600:supply & distribution*; D004008:Diclofenac / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases