[Relationship between six single nucleotide polymorphisms of angiotensinogen gene and essential hypertension].
OBJECTIVE
To evaluate the relationship of six single nucleotide polymorphisms(SNPs) and their haplotypes of angiotensinogen(AGT) gene to essential hypertension(EH) in Chinese Han population.


METHODS
The genotypes in 185 patients with EH and 185 healthy controls were determined by the method of ABI PRISM SNaPshot Multiplex Kit using six AGT gene polymorphisms at position -217(G/A), -152(G/A), -20(A/C) and -6(G/A) in the promoter region and T174M, M235T in exon 2.


RESULTS
The distribution of AGT genotypes and alleles frequencies showed no significant difference between the group of EH and group of controls (P>0.05). However, haplotype analysis revealed that H4 haplotype frequency, which included -152A, -20C, -6A and 235T alleles, was significantly increased in the group of EH (P<0.05).


CONCLUSIONS
G-152A, A-20C, G-6A and M235T polymorphisms of AGT gene might play an important role in the occurrence of EH in Chinese Han population.
Liu
Yan
Y
Department of Cardiology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai, 200025 PR China. liuliuyanyan@etang.com
Jin
Wei
W
Jiang
Zheng-wen
ZW
Zhang
Kui-xing
KX
Sheng
Hai-hui
HH
Jin
Lin
L
Sheng
Ya-yun
YY
Huang
Wei
W
Yu
Jin-de
JD
D000328:Adult; D000368:Aged; D000808:Angiotensinogen / Q000097:blood / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D000808:Angiotensinogen