Clarithromycin-induced eosinophilic pneumonia.
Clarithromycin (CAM) has been widely used for the treatment of respiratory infection. Macrolides are generally well tolerated and their adverse reactions are rare. An 80-year-old woman with nontuberculous mycobacterium infection was treated with combined chemotherapy, including isoniazid, rifampicin, and ethambutol. She developed a fever and peripheral blood eosinophilia, and new subpleural consolidations were observed on chest radiography three days after add-on therapy with CAM. The symptoms and clinical findings improved with the withdrawal of CAM. Histopathologic examinations confirmed the diagnosis of eosinophilic pneumonia. This is the first report of CAM-induced eosinophilic pneumonia.
Ohnishi
Hiroshi
H
Second Department of Internal Medicine, Ehime University School of Medicine, Ehime.
Abe
Masahiro
M
Yokoyama
Akihito
A
Hamada
Hironobu
H
Ito
Ryoji
R
Hirayama
Takeru
T
Nishimura
Kazutaka
K
Higaki
Jitsuo
J
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017291:Clarithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D004804:Eosinophils / Q000502:physiology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D009164:Mycobacterium Infections / Q000188:drug therapy; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011859:Radiography
D000900:Anti-Bacterial Agents; D017291:Clarithromycin