title: A mathematical model for the in vitro kinetics of the anti-cancer agent topotecan.
abstract: In this paper a compartmental modelling approach is applied to provide a mathematical description of the activity of the anti-cancer agent topotecan, and delivery to its nuclear DNA target following administration. The activity of topotecan in defined buffers is first modelled using a linear two compartment model that then forms the basis of a cell based model for drug activity in live cell experiments. An identifiability analysis is performed before parameter estimation to ensure that the model output (i.e., continuous, perfect and noise-free data) uniquely determines the parameters. Parameter estimation is performed using experimental data which offers concentrations of active and inactive forms of topotecan from high performance liquid chromatography methods.
authors.affiliation: School of Engineering, University of Warwick, Coventry CV4 7AL, UK.
authors.forename: Neil D
authors.initials: ND
authors.lastname: Evans
authors.forename: Rachel J
authors.initials: RJ
authors.lastname: Errington
authors.forename: Michael
authors.initials: M
authors.lastname: Shelley
authors.forename: Graham P
authors.initials: GP
authors.lastname: Feeney
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Chapman
authors.forename: Keith R
authors.initials: KR
authors.lastname: Godfrey
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Smith
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Chappell
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D002451:Cell Compartmentation; D003198:Computer Simulation; D004334:Drug Administration Schedule; D006801:Humans; D008954:Models, Biological; D019772:Topotecan / Q000493:pharmacokinetics*
chemical_list: D000970:Antineoplastic Agents; D019772:Topotecan