Antileishmanial and antifungal acridone derivatives from the roots of Thamnosma rhodesica.
Eight furanocoumarins, one coumarin and four acridone derivatives have been identified in the roots of Thamnosma rhodesica (Rutaceae). Rhodesiacridone, one of these acridone derivatives, is reported here for the first time. Its structure was elucidated by spectrometric methods including ESI-HR, EI, DCI mass spectrometry, 1H, 13C and 2D NMR experiments. This novel compound showed activities against the intracellular form of a human pathogen, the protozoan parasite Leishmania major. Two known acridone related compounds, gravacridonediol and 1-hydroxy-10-methylacridone, exhibited activities against the intracellular form of the same parasite and the fungus Cladosporium cucumerinum, respectively.
Ahua
Kouassi Maximin
KM
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, CH-1015 Lausanne, Switzerland.
Ioset
Jean-Robert
JR
Ransijn
Adriana
A
Mauël
Jacques
J
Mavi
Steven
S
Hostettmann
Kurt
K
D000166:Acridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D054831:Acridones; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002963:Cladosporium / Q000187:drug effects; D006801:Humans; D018320:Leishmania major / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests / Q000379:methods; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009761:Nystatin / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
D000166:Acridines; D054831:Acridones; D000935:Antifungal Agents; D000981:Antiprotozoal Agents; D009761:Nystatin; C041300:acridone; D000666:Amphotericin B