Serotonin 1B (5HT-1B) receptor polymorphism (G861C) in suicide victims: association studies in German and Slavic population.
Serotonergic dysfunction is believed to be involved in the susceptibility to suicide due to functional alternations in the serotonin-related genes. Serotonin 1B (5HT-1B) receptor mediates aggressive behavior in mice models and was proposed to be involved in the control of aggression and impulsivity in humans. In this study we have investigated the association of G861C polymorphism of the 5HT-1B receptor gene with suicide commitment. Study was based on two independent samples, one of German (245 suicide victims vs. 248 controls) and the other of Slavic/Croatian (118 suicide victims vs. 192 controls) ethnicity. No significant differences in allele or genotype frequencies between victims and controls were demonstrated either in German or Croatian sample. There were no differences in allele frequencies between German and Croatian population, and the combined sample, having high statistical power, also did not demonstrate significant differences between victims and controls. Results provide evidence that the investigated 5HT-1B receptor gene variants are not implicated in the susceptibility to suicide.
Stefulj
Jasminka
J
Laboratory of Neurochemistry and Molecular Neurobiology, Rudjer Boskovic Institute, Bijenicka 54, Zagreb, Croatia.
Büttner
Andreas
A
Skavic
Josip
J
Zill
Peter
P
Balija
Melita
M
Eisenmenger
Wolfgang
W
Bondy
Brigitta
B
Jernej
Branimir
B
D000328:Adult; D000368:Aged; D000483:Alleles; D017523:Croatia; D004247:DNA / Q000235:genetics / Q000378:metabolism; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D004587:Electrophoresis, Agar Gel; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D013405:Suicide / Q000208:ethnology / Q000523:psychology*
D044302:Receptor, Serotonin, 5-HT1B; D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; C024400:GTYRAC-specific type II deoxyribonucleases