title: Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway.
authors.affiliation: Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. devans@cmb.biosci.wayne.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Evans
authors.forename: Hedeel I
authors.initials: HI
authors.lastname: Guy
mesh_terms: D000818:Animals; D019731:Carbon-Nitrogen Ligases / Q000378:metabolism; D002467:Cell Nucleus / Q000201:enzymology; D003600:Cytosol / Q000201:enzymology; D000090722:Dihydroorotate Dehydrogenase; D006706:Homeostasis; D009097:Multienzyme Complexes / Q000378:metabolism; D009962:Orotate Phosphoribosyltransferase / Q000378:metabolism; D009964:Orotidine-5'-Phosphate Decarboxylase / Q000378:metabolism; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000378:metabolism; D011743:Pyrimidines / Q000096:biosynthesis*
chemical_list: D000090722:Dihydroorotate Dehydrogenase; D009097:Multienzyme Complexes; D011743:Pyrimidines; C027157:uridine 5'-monophosphate synthase; D044925:Oxidoreductases Acting on CH-CH Group Donors; D009962:Orotate Phosphoribosyltransferase; D009964:Orotidine-5'-Phosphate Decarboxylase; D019731:Carbon-Nitrogen Ligases; C019951:CTP synthetase; C030986:pyrimidine