title: Over-expression of the testis-specific gene TSGA10 in cancers and its immunogenicity.
abstract: The TSGA10 gene was originally isolated in normal testis by differential mRNA display. TSGA10 is located on chromosome 2q11.2 and consists of 19 exons extending over 3 kb. TSGA10 mRNA expression was investigated in normal and malignant tissues using quantitative real-time RT-PCR. It was predominantly expressed in the testis in adult normal tissues. In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. Serological analysis revealed that 3 out of 346 patients with various types of cancer possessed antibody against recombinant TSGA10 protein. They included 2 patients with hepatocellular carcinoma and a patient with malignant melanoma.
authors.affiliation: Departments of Immunology, Okayama University Graduate School of Medicine and Dentistry, Japan. meneki@md.okayama-u.ac.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Tanaka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ono
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Sato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nakada
authors.forename: Fumihito
authors.initials: F
authors.lastname: Koizumi
authors.forename: Kosei
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Okumura
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamashita
authors.forename: Mikio
authors.initials: M
authors.lastname: Ohtsuka
authors.forename: Kenji
authors.initials: K
authors.lastname: Asagoe
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamasaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Keiji
authors.initials: K
authors.lastname: Iwatsuki
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakayama
mesh_terms: D000906:Antibodies / Q000097:blood; D003598:Cytoskeletal Proteins; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013737:Testis; D015854:Up-Regulation
chemical_list: D000906:Antibodies; D003598:Cytoskeletal Proteins; D011506:Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; C429756:TSGA10 protein, human