title: Intracranial venous thrombosis after hypoxic-ischemic brain insult in two newborns: could low serum carnitine levels have contributed?
abstract: Sinovenous thrombosis is a definite cause of mortality or morbidity in newborns. Perinatal hypoxia is one of the well known risk factors. Two term newborns were diagnosed to have cerebral venous thrombosis after a hypoxic-ischemic insult. They were later found to have carnitine deficiency. Both of the patients died. Carnitine was previously shown to have inhibitory effects on thrombogenesis in experimental studies. The possible contribution of carnitine in thrombogenesis was discussed.
authors.affiliation: Gazi University Department of Pediatrics, Gazi Hospital, Besevler, Ankara 06540, Turkey. fatihezgu@isbank.net.tr
authors.forename: Fatih Süheyl
authors.initials: FS
authors.lastname: Ezgü
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Atalay
authors.forename: Alev
authors.initials: A
authors.lastname: Hasanoğlu
authors.forename: Kivilcim
authors.initials: K
authors.lastname: Gücüyener
authors.forename: Esin
authors.initials: E
authors.lastname: Koç
authors.forename: Ebru
authors.initials: E
authors.lastname: Ergenekon
mesh_terms: D002545:Brain Ischemia / Q000209:etiology*; D002331:Carnitine / Q000172:deficiency*; D017809:Fatal Outcome; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology*; D007231:Infant, Newborn; D020767:Intracranial Thrombosis / Q000209:etiology*; D008297:Male; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D002331:Carnitine