Review article: Tissue engineering of semilunar heart valves: current status and future developments.
Heart valve replacement represents the most common surgical therapy for end-stage valvular heart diseases. One major drawback that all heart valve replacements have in common is the lack of growth, repair, and remodeling capability once implanted into the body. The emerging field of tissue engineering is focusing on the in-vitro generation of functional, living semilunar heart valve replacements. This review presents a state-of-the-art overview of the physiological and biomechanical requirements of semilunar heart valves, focusing on the aortic valve. Moreover, recent heart valve tissue engineering is summarized and future options and improvements on the way towards clinical applications are discussed.
Mol
Anita
A
University Hospital Zurich, Clinic for Cardiovascular Surgery, Zurich, Switzerland.
Bouten
Carlijn V C
CV
Baaijens
Frank P T
FP
Zünd
Gregor
G
Turina
Marko I
MI
Hoerstrup
Simon P
SP
D000818:Animals; D001021:Aortic Valve / Q000473:pathology / Q000601:surgery; D001705:Bioprosthesis / Q000639:trends; D005544:Forecasting; D006349:Heart Valve Diseases / Q000601:surgery; D006350:Heart Valve Prosthesis / Q000639:trends*; D019918:Heart Valve Prosthesis Implantation / Q000639:trends; D006801:Humans; D011474:Prosthesis Design / Q000639:trends; D023822:Tissue Engineering / Q000639:trends*