Cytochrome P450 1A1 and manganese superoxide dismutase gene polymorphisms in Behçet's disease.
OBJECTIVE
To investigate the association of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) gene polymorphisms with susceptibility to Behçet's disease (BD) in Taiwan.


METHODS
The polymorphisms of CYP1A1 and MnSOD genes were determined in 51 patients with BD and 91 healthy controls by polymerase chain reaction/restriction fragment length polymorphism methods.


RESULTS
The frequencies of CYP1A1 4889G and 4887A were significantly increased in patients with BD. In contrast, there was no significant difference in the frequencies of MnSOD gene polymorphisms between patients with BD and controls. Linkage disequilibrium was found between CYP1A1 4889G and CYP1A1 6235C in controls and patients with BD. However, a similar finding could not be found between CYP1A1 4889G and 4887A. We also found that the association of CYP1A1 4889G with BD was dependent on the presence of CYP1A1 4887A. On the other hand, the association of CYP1A1 4887A with BD was dependent on the presence of CYP1A1 4889G. An additive effect of CYP1A1 4889G and 4887A on the susceptibility to BD could be found.


CONCLUSIONS
Simultaneous presence of CYP1A1 4889G and 4887A is associated with development of BD in Taiwan.
Yen
Jeng-Hsien
JH
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsing City, Taiwan. jehsye@kmu.edu.tw
Tsai
Wen-Chun
WC
Lin
Chia-Hui
CH
Ou
Tsan-Teng
TT
Hu
Chaur-Jong
CJ
Liu
Hong-Wen
HW
D000328:Adult; D001528:Behcet Syndrome / Q000201:enzymology* / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*; D013624:Taiwan
D019363:Cytochrome P-450 CYP1A1; D013482:Superoxide Dismutase