NAADP-induced Ca2+ release -- a new signalling pathway.
Changes in cystosolic Ca2+ concentration are critical for the regulation of numerous cellular events. Mobilisation of intracellular Ca2+ stores by Ca2+ mobilising messengers is a highly conserved mechanism whereby different agonists mediate their cellular effects. NAADP is the newest of these messengers to be described. Accumulating evidence suggests that NAADP targets a novel intracellular Ca2+ release channel that under certain conditions can inactivate prior to opening. These channels are likely located on Ca2+ stores distinct from the endoplasmic reticulum, the activation of which evokes complex changes in Ca2+ involving cross-talk with other intracellular Ca2+ channels. Recent demonstrations of changes in cellular NAADP levels by physiologically relevant stimuli establish the importance of this molecule in the control of calcium dynamics.
Patel
Sandip
S
Department of Physiology, University College London, London, United Kingdom. patel.s@ucl.ac.uk
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009249:NADP / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D020239:Receptor Cross-Talk
D015220:Calcium Channels; D009249:NADP; C024376:NAADP; D002118:Calcium