Analytical studies and application of reaction of promazine and thioridazine hydrochlorides with some oxidants.
The run and analytical application of oxidation reaction of promazine (PM) and thioridazine (TR) hydrochlorides with iron(III) and ferrocyanide(III) are described. The coloured products of oxidation absorb at 512 nm for promazine and 634 nm for thioridazine. This property is a basis of a rapid, accurate and sensitive spectrophotometric method for determination of these phenothiazines. The elaborated methods allow to determine 3-28 microgPM/ml in Fe(III)-PM and 2-11 microgPM/ml in [Fe(CN)6](3-)-PM systems, 2.5-22 microgTR/ml in the Fe(III)-TR and 4-16 microgTR/ml in [Fe(CN)6](3-)-TR systems.
Puzanowska-Tarasiewicz
Helena
H
Institute of Chemistry, University of Białystok, 1 Hurtowa Str., 15-339 Białystok, Poland.
Karpińska
Joanna
J
D016877:Oxidants / Q000032:analysis* / Q000737:chemistry; D010084:Oxidation-Reduction; D011395:Promazine / Q000032:analysis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013881:Thioridazine / Q000032:analysis* / Q000737:chemistry
D016877:Oxidants; D013881:Thioridazine; D011395:Promazine