The role of interleukin 10 in the pathogenesis and potential treatment of skin diseases.
Interleukin 10 (IL-10) is a key cytokine produced by a multitude of immune effector cells and possesses distinct regulatory effects on immune functioning in the skin. In this article we report the current understanding of the immunobiology of IL-10 and identify the role of IL-10 in cutaneous infection as well as in autoimmune and neoplastic processes. We reviewed the literature to examine the function of IL-10 in different cutaneous disorders. IL-10 can influence and potentially treat T1/T2 differentiation, antigen-presenting cell functioning, antigen-presenting cell-mediated T-cell activation, and T-cell, B-cell, and mast cell growth and differentiation that is aberrant in various disease processes. The literature consensus is that the multitude of effects of IL-10 contribute to the pathogenesis of different skin disorders. In certain circumstances IL-10 could represent novel therapeutic approaches to treating cutaneous diseases.


OBJECTIVE
At the conclusion of this learning activity, participants should be acquainted with the role of IL-10 in many infectious diseases, autoimmune skin disease, inflammatory processes, and malignancy. Its possible role in the resolution of various skin diseases should be better understood.
Weiss
Elliot
E
Department of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.
Mamelak
Adam Joseph
AJ
La Morgia
Stephania
S
Wang
Binghe
B
Feliciani
Claudio
C
Tulli
Antonio
A
Sauder
Daniel Nathan
DN
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000503:physiopathology; D003872:Dermatitis / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D016753:Interleukin-10 / Q000276:immunology / Q000502:physiology* / Q000627:therapeutic use; D011565:Psoriasis / Q000276:immunology / Q000503:physiopathology; D012867:Skin / Q000276:immunology; D012871:Skin Diseases / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D012874:Skin Diseases, Infectious / Q000276:immunology / Q000503:physiopathology; D012878:Skin Neoplasms / Q000276:immunology / Q000503:physiopathology
D016753:Interleukin-10