title: Delayed gastric emptying in patients with diffuse versus limited systemic sclerosis, unrelated to gastrointestinal symptoms and myoelectric gastric activity.
abstract: OBJECTIVE
  To study the gastric function in patients with diffuse and limited systemic sclerosis (SSc) in relation to the degree of upper gastrointestinal symptoms.
  
  
  METHODS
  Scintigraphic gastric emptying and recording of the myoelectric signals of the stomach were examined in 15 patients with diffuse SSc (dSSc), 13 patients with limited SSc (lSSc) and 15 healthy controls. The frequency of upper gastrointestinal symptoms was determined using a questionnaire.
  
  
  RESULTS
  Patients with dSSc had slower gastric emptying (scintigraphic gastric half-emptying time median (Md) 103 min, range 75-447 min) than control subjects (Md 70 min, range 38-94) and patients with lSSc (Md 76 min, range 43-460). Electrogastrographic recordings did not differ between dSSc, lSSc or controls. Symptoms tended to be more abundant in dSSc patients than in lSSc patients, however, patients with a high frequency of symptoms did not differ from patients with low frequency of symptoms in gastric function, as measured with scintigraphic gastric emptying or electrogastrography (EGG). Neither EGG nor a thorough review of upper gastrointestinal symptoms could predict delayed gastric emptying.
  
  
  CONCLUSIONS
  The higher prevalence of delayed gastric emptying in patients with dSSc in this study indicates a more severe involvement of the gastrointestinal tract in dSSc than in lSSc, and stresses the importance of differentiating between the subtypes of SSc patients. Since EGG dysrythmia did not correlate with gastric emptying we concluded that factors other than defective myoelectric signals might contribute to a disturbed gastric function.
authors.affiliation: Department of Medicine, Division of Rheumatology, University Hospital, Uppsala, Sweden. karin.franck-larsson@medicin.uas.lul.se
authors.forename: K
authors.initials: K
authors.lastname: Franck-Larsson
authors.forename: H
authors.initials: H
authors.lastname: Hedenström
authors.forename: R
authors.initials: R
authors.lastname: Dahl
authors.forename: A
authors.initials: A
authors.lastname: Rönnblom
mesh_terms: D016022:Case-Control Studies; D004568:Electrodiagnosis / Q000379:methods; D004867:Equipment Design; D004869:Equipment Safety; D005260:Female; D005500:Follow-Up Studies; D005746:Gastric Emptying / Q000502:physiology*; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation; D016065:Myoelectric Complex, Migrating; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D045743:Scleroderma, Diffuse / Q000175:diagnosis*; D045745:Scleroderma, Limited / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric