title: Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats.
abstract: The ethanolic extract of Trianthema portulacastrum L. (Aizoaceae) showed a significant dose dependent (100 mg, 200 mg/kg p.o. 10x) protective effect against paracetamol and thioacetamide induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin (BRN), and total protein (TP). The plant extract completely prevented the toxic effects of paracetamol (acetaminophen) and thioacetamide on the above serum parameters. A significant hepatoprotective activity of the ethanolic extracts of Trianthema portulacastrum L. was reported.
authors.affiliation: Center for Biotechnology, Muthayammal College of Arts and Sciences, Rasipuram, Namakkal 637 408, Tamilnadu, India.
authors.forename: G
authors.initials: G
authors.lastname: Kumar
authors.forename: G Sharmila
authors.initials: GS
authors.lastname: Banu
authors.forename: P Vanitha
authors.initials: PV
authors.lastname: Pappa
authors.forename: M
authors.initials: M
authors.lastname: Sundararajan
authors.forename: M Rajasekara
authors.initials: MR
authors.lastname: Pandian
mesh_terms: D000082:Acetaminophen; D035722:Aizoaceae; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013853:Thioacetamide
chemical_list: D010936:Plant Extracts; D020011:Protective Agents; D013853:Thioacetamide; D000082:Acetaminophen