[Distribution of calcitonin gene-related peptide in guinea pig cochlea].
OBJECTIVE
To observe the distribution of CGRP in guinea pig cochlea.


METHODS
CGRP was labeled by immunostaning technique. Distribution of CGRP immunoreactivity was observed with light microscopy.


RESULTS
CGRP immunoreactivity was located in SGN, nerve fibers at osseous spiral lamina, stria vascularis, IHC, adjacent area of OHC and Deiters' cells.


CONCLUSIONS
CGRP distributes extensively in guinea pig cochlea. CGRP may play an important role as neurotransmitter and/or neuromodulator to hearing function by modulating HC, supporting cells, SGN and other neurons along the process of auditory nerve. It may have effect on on cochlear blood flow, too.
Qi
Benming
B
Department of Otolaryngology, First People's Hospital of Yunnan Province, Kunming, 650001, China.
Huang
Xiang
X
Zhu
Liangru
L
Tian
Xinghua
X
Wang
Jibao
J
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D003051:Cochlea / Q000098:blood supply / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D007760:Labyrinth Supporting Cells / Q000378:metabolism; D008297:Male; D013137:Spiral Lamina / Q000378:metabolism*; D013316:Stria Vascularis / Q000378:metabolism*
D015740:Calcitonin Gene-Related Peptide