title: Radiochemotherapy in locally invasive non-metastatic carcinoma of the bladder.
abstract: We therefore believe that our therapeutic concept is a true alternative to primary cystectomy, with comparable survival rates. We observed a high rate of functional organ preservation in long-term survivors (79% with complete remission (CR) after 5 years). Radiation bladders were rare at doses not exceeding 60 Gy. Age and co-morbidity were not exclusion criteria. Presence of a competent and cooperative radiotherapy department is a precondition to preventing akinetic radiation bladders. Continuous life-long follow-up is necessary. Cystectomy, together with modern urinary diversions, is still necessary; it is performed in non-responders and in patients with muscle-invasive recurrences.
authors.affiliation: University Department of Urology, Friedrich Alexander University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: J L
authors.initials: JL
authors.lastname: Brod
authors.forename: R
authors.initials: R
authors.lastname: Kühn
authors.forename: W
authors.initials: W
authors.lastname: Schafhauser
authors.forename: K M
authors.initials: KM
authors.lastname: Schrott
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D020127:Recovery of Function; D012074:Remission Induction; D016019:Survival Analysis; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D011838:Radiation-Sensitizing Agents; D002945:Cisplatin