Low concentration of nitrite and nitrate in the cerebrospinal fluid from schizophrenic patients: a pilot study.
Some evidence suggests a dysfunctional nitric oxide (NO) system in the brain of schizophrenic subjects. We measured the concentrations of the stable metabolites of NO, nitrite, and nitrate in the cerebrospinal fluid (CSF) from schizophrenic and control patients with other neurological disorders and found lowered levels in the schizophrenic group as compared with the control group. This finding supports the hypothesis of a NO system reduction in the brain of schizophrenic subjects.
Ramirez
Jesus
J
Department of Neuropsychiatry, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Mexico City, Mexico.
Garnica
Rodrigo
R
Boll
Marie-Catherine
MC
Montes
Sergio
S
Rios
Camilo
C
D000328:Adult; D001921:Brain / Q000378:metabolism; D005260:Female; D006261:Headache / Q000134:cerebrospinal fluid / Q000175:diagnosis; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis; D009566:Nitrates / Q000134:cerebrospinal fluid*; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000134:cerebrospinal fluid*; D010865:Pilot Projects; D011434:Proprioception / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000378:metabolism; D013129:Spinal Puncture
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide