Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.
Neuroprotective effects of flavones were examined. Luteolin and apigenin exhibited neuroprotection against oxidative stress-induced cell death in SH-SY5Y cells. Free radical scavenging activity and neuroprotection assays revealed that flavones exerted their neuroprotective effects via the direct interaction with the apoptotic caspase pathway independently of their antioxidant activity.
Kang
Sam Sik
SS
College of Pharmacy and Natural Products Research Institute, Seoul National University, Seoul 110-460, South Korea.
Lee
Ji Yeon
JY
Choi
Yoo Keum
YK
Kim
Gap Seok
GS
Han
Byung Hee
BH
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D047309:Flavones / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*
D047309:Flavones; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D006861:Hydrogen Peroxide