title: Ondansetron for paediatric uraemic pruritus: a case report.
abstract: Pruritus, secondary to chronic renal failure, can be an extremely distressing symptom. A 15-year-old girl, in end-stage renal disease, presented with pruritus that did not improve on starting peritoneal dialysis. Despite normalising the calcium, phosphate and parathyroid levels, pruritus worsened and showed no response to antihistamines. She was commenced on ondansetron and showed dramatic improvement. Severe uraemic pruritus is rare, but distressing in children and can improve with ondansetron.
authors.affiliation: Department of Paediatric Nephrology, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. deshpp@suht.swest.nhs.uk
authors.forename: Pankaj V
authors.initials: PV
authors.lastname: Deshpande
mesh_terms: D000293:Adolescent; D000982:Antipruritics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D017294:Ondansetron / Q000627:therapeutic use*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D014511:Uremia / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000982:Antipruritics; D017294:Ondansetron