title: Fibrillin-1 and elastin are differentially expressed in hypertrophic scars and keloids.
abstract: Hypertrophic scars and keloids are two forms of excessive cutaneous scarring. Considering the importance of extracellular matrix elements in tissue repair, a morphological and quantitative analysis of the elastic system components (fibrillin-1 and elastin) was performed in normal skin, normal scars, hypertrophic scars, and keloids. In superficial and deep dermis, fibrillin-1 volume density was significantly higher in normal skin compared with normal scars, hypertrophic scars, and keloids. The fibrillin-1 volume density did not show differences between hypertrophic scars and keloids in superficial or deep dermis. In superficial dermis, elastin volume density was higher in normal skin compared with normal scars, hypertrophic scars, and keloids. In deep dermis, the elastin volume density was higher in keloids compared with normal skins, normal scars, and hypertrophic scars. We showed that the distribution of fibrillin-1 and elastin is disrupted in all kinds of scars analyzed, but there are two patterns: one for normal scars and another for excessive scars.
authors.affiliation: Departamento de Histologia e Embriologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Thaís P
authors.initials: TP
authors.lastname: Amadeu
authors.forename: André S
authors.initials: AS
authors.lastname: Braune
authors.forename: Luís C
authors.initials: LC
authors.lastname: Porto
authors.forename: Alexis
authors.initials: A
authors.lastname: Desmoulière
authors.forename: Andréa M A
authors.initials: AM
authors.lastname: Costa
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D017439:Cicatrix, Hypertrophic / Q000378:metabolism* / Q000473:pathology; D004549:Elastin / Q000378:metabolism*; D005260:Female; D000071838:Fibrillin-1; D000071837:Fibrillins; D006801:Humans; D007627:Keloid / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism*; D008875:Middle Aged; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing / Q000502:physiology; D054392:Adipokines
chemical_list: D004549:Elastin; D000071838:Fibrillin-1; D000071837:Fibrillins; D008840:Microfilament Proteins; C000605722:FBN1 protein, human; D054392:Adipokines