1,4-addition of enolates to alpha,beta-unsaturated ketones within a micro reactor.
We demonstrate the formation of a series of diketone enolates and their subsequent reaction with alpha,beta-unsaturated carbonyl compounds in order to prepare a variety of Michael adducts. In all cases, the conversions observed within a micro reactor were greater than those obtained in batch.
Wiles
Charlotte
C
Department of Chemistry, Faculty of Science and the Environment, University of Hull, Cottingham Road, Hull, UKHU6 7RX.
Watts
Paul
P
Haswell
Stephen J
SJ
Pombo-Villar
Esteban
E