title: Stereoselective total synthesis of antitumor macrolide (+)-rhizoxin D.
abstract: [structure: see text] A convergent, stereoselective total synthesis of the macrolide antitumor agent rhizoxin D is described. (+)-DIPCl-promoted asymmetric aldol reaction, Evans-Tishchenko 1,3-diol synthesis, modified Julia coupling, and Horner-Wadsworth-Emmons reactions are featured.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1396, USA.
authors.forename: Yueheng
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Hong
authors.forename: Steven D
authors.initials: SD
authors.lastname: Burke
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; D018942:Macrolides; C479980:rhizoxin D; C041443:rhizoxin