title: Mortality and long term morbidity in esophageal atresia: the reduced impact of low birth weight and maturity on surgical outcome.
abstract: Progress in perinatal and postoperative techniques has reduced the prognostic role of traditional risk factors in esophageal atresia (EA). This paper reports on 75 cases of esophageal anomalies observed between 1992 and 2002 and followed after surgery from a minimum of six months to a maximum of ten years (mean five years). The impact on survival of birth weight, week of delivery, associated anomalies and need of ventilatory support at birth are discussed. Twenty-four patients were born before 37 weeks of gestation, 18 weighed less than 2000 g.; major anomalies affected 11 neonates, 23 cases required mechanical ventilation at birth. Seventy-four patients were operated on with a 90.6% survival rate; no deaths were related to surgical treatment. Three cases required reoperation for postoperative complications. Birth weight and week of delivery did not seem to influence outcome; this is affected by severe associated cardiovascular anomalies and the need of ventilation at birth. Follow up at 24 months on 51 patients, revealed respiratory problems in 12 cases and severe gastro-esophageal reflux in 16. This affected quality of life of EA patients and required long term medical attention; improvement with growth was observed. No correlation between perinatal conditions and late sequelae could be demonstrated in our series.
authors.affiliation: Pediatric Surgical Division, San Camillo Hospital, Catholic University Hospital, Rome, Italy. a.calisti@tiscali.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Calisti
authors.forename: Lucia
authors.initials: L
authors.lastname: Oriolo
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Nanni
authors.forename: Philippe
authors.initials: P
authors.lastname: Molle
authors.forename: Vito
authors.initials: V
authors.lastname: Briganti
authors.forename: Carmine
authors.initials: C
authors.lastname: D'Urzo
mesh_terms: D001724:Birth Weight; D004933:Esophageal Atresia / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D008499:Medical Records; D012121:Respiration, Artificial; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis