title: [Effect of L-lysine-alpha-oxidase gel on development of ophthalmic herpes and herpetic skin lesions in rabbit].
abstract: The effect of various doses of L-lysine-alpha-oxidase gel (1.4-3.5 and 70 mcg/ml) on development of eye and skin herpetic lesions due to type 1 herpes simplex virus was studied on rabbits. The doses of 1.4 to 3.5 mcg/ml were not sufficient for the therapeutic effect. The dose of 70 mcg/ml provided complete healing of the lesions in 3 to 4 days. The results were confirmed by the immunological tests.
authors.affiliation: Russian Peoples' Friendship University, Moscow. N.F. Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow.
authors.forename: I P
authors.initials: IP
authors.lastname: Smirnova
authors.forename: S B
authors.initials: SB
authors.lastname: Alekseev
authors.forename: V M
authors.initials: VM
authors.lastname: Podboronov
mesh_terms: D000581:Amidohydrolases / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005782:Gels; D006561:Herpes Simplex / Q000188:drug therapy* / Q000473:pathology; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy* / Q000473:pathology; D011817:Rabbits; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D005782:Gels; D000581:Amidohydrolases; C076449:L-lysine-lactamase