Application of the four-component Ugi condensation for the preparation of sulfated glycoconjugate libraries.
A focused library of novel, sulfated glycoconjugates was synthesized by utilizing carbohydrate-derived blocks in the four-component Ugi condensation. Library members comprise a sulfated monosaccharide linked by various spacers to either an aromatic or monosulfated moiety, or a second sulfated monosaccharide. The affinities of these heparan sulfate (HS) mimetics for the HS-binding fibroblast growth factors FGF-1 and FGF-2 were measured via a surface plasmon resonance solution affinity assay.
Liu
Ligong
L
Drug Design Group, Progen Industries Ltd, 2806 Ipswich Rd, Darra, Qld 4076, Australia.
Ping Li
Cai
C
Cochran
Siska
S
Ferro
Vito
V
D016220:Fibroblast Growth Factor 1 / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000737:chemistry; D006001:Glycoconjugates / Q000737:chemistry*; D018716:Molecular Mimicry; D013431:Sulfates / Q000737:chemistry*; D020349:Surface Plasmon Resonance
D006001:Glycoconjugates; D013431:Sulfates; D016222:Fibroblast Growth Factor 2; D016220:Fibroblast Growth Factor 1