title: Effect of a new beta-sitosterol analogue on plasma lipid concentrations in rats.
abstract: N-Substituted succinamic acid beta-sitosteryl ester derivatives were prepared and evaluated. Compounds 1 and 2 were prepared in 76-92% yields by the reaction of beta-sitosterol and succinic anhydride, followed by the activation of the resulting acid compound 1 by thionyl chloride or methyl chloroformate, and finally by amination with appropriate amines. Compound 2a (DANA87) was also easily obtained in one step by the direct addition of beta-sitosterol to dicyclohexylcarbodiimide (DCC) in 80% yield. Administration of the dietary compound DANA87 resulted in significant decreases in total plasma cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations compared with controls in a rat model. High-density lipoprotein cholesterol and plasma triglyceride levels were not affected. These findings indicate that DANA87 functions as TC and LDL cholesterol-reducing agent.
authors.affiliation: Department of Chemistry, Mokwon University, Daejeon, Korea. yhsong@mokwon.ac.kr
authors.forename: Yang-Heon
authors.initials: YH
authors.lastname: Song
authors.forename: Soonil
authors.initials: S
authors.lastname: Hong
authors.forename: Hongsan
authors.initials: H
authors.lastname: Lim
authors.forename: Jinmoo
authors.initials: J
authors.lastname: Seo
authors.forename: Sungjoo
authors.initials: S
authors.lastname: Chung
authors.forename: Insook
authors.initials: I
authors.lastname: No
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Lee
authors.forename: Michung
authors.initials: M
authors.lastname: Yoon
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000737:chemistry* / Q000494:pharmacology*; D008076:Cholesterol, HDL / Q000037:antagonists & inhibitors / Q000097:blood*; D008078:Cholesterol, LDL / Q000037:antagonists & inhibitors / Q000097:blood*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012855:Sitosterols / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D012855:Sitosterols; C025473:gamma-sitosterol