Novel treatment strategies in follicular lymphoma.
Malignant lymphomas are a heterogenous group of malignancies, belonging to the 10 most frequent types of cancers worldwide. In indolent lymphoma only patients with limited stage I/II (Ann Arbor) can be potentially cured by local irradiation. However, about 85% of cases present with advanced stage; for these patients no established therapeutic strategy with curative potential exist. The development of the anti-CD20 monoclonal antibody rituximab has been one of the major contributions in the field of anti-lymphoma treatment in the recent years. Various clinical trials have suggested the combination of chemotherapy and rituximab to be highly effective in de novo as well as relapsed indolent lymphomas.
Buske
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Dept. of Internal Medicine III, University of Munich, Klinikum Grosshadern, Munich, Germany.
Dreyling
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Unterhalt
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Hiddemann
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D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008224:Lymphoma, Follicular / Q000188:drug therapy / Q000628:therapy*; D011241:Prednisone / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone