title: Effect of Powerdental on caries-inducing properties of Streptococcus mutans and TNF-alpha secretion from HMC-1 cells.
abstract: We studied the inhibitory effect of Powerdental on the growth and acid production of Streptococcus mutans as well as secretion of pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). The growth of Streptococcus mutans was reduced by the presence of the Powerdental (1 mg/ml) and NaCl (1 mg/ml) significantly, and the positive control group (1% NaF) also exhibited a significant antibacterial activity. The decrease of pH was significantly inhibited in the presence of Powerdental (1 mg/ml) compared to the control group. The decrease in pH was also inhibited in the presence of positive control (1% NaF), but the bamboo salt alone did not show inhibitory activity. We also found that Powerdental (0.01 mg/ml) inhibited significantly the secretion of TNF-alpha with 46.5+/-0.2% from human mast cells. Our results suggest that Powerdental contributes to the prevention or treatment of periodontitis and other oral diseases or inflammatory diseases.
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Wonkwang University, Iksan, Republic of Korea.
authors.forename: Yong-Ouk
authors.initials: YO
authors.lastname: You
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Hyeon-Hee
authors.initials: HH
authors.lastname: Yu
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Yoo
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Yun-Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Shin
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000143:Acids / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002327:Cariostatic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004339:Drug Compounding; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D008826:Microbial Sensitivity Tests; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D031787:Sasa / Q000737:chemistry*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology
chemical_list: D000143:Acids; D000893:Anti-Inflammatory Agents; D002327:Cariostatic Agents; D028321:Plant Preparations; D014409:Tumor Necrosis Factor-alpha