title: Prenatal diagnosis of intrauterine premature closure of the ductus arteriosus following maternal diclofenac application.
abstract: We report a case of prenatal diagnosis of premature closure of the ductus arteriosus following maternal diclofenac therapy at 35 weeks of gestation. Fetal echocardiography at 37 weeks of gestation revealed a dilated right ventricle with moderate tricuspid regurgitation, pulmonary insufficiency and complete closure of the ductus arteriosus. Immediate Cesarean section resulted in an excellent neonatal outcome. Whereas the effect of indomethacin on prenatal ductal constriction is well known, widely prescribed non-steroidal anti-inflammatory drugs such as diclofenac can have an equally deleterious effect and are best avoided in the third trimester of pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Innsbruck, Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Auer
authors.forename: C
authors.initials: C
authors.lastname: Brezinka
authors.forename: P
authors.initials: P
authors.lastname: Eller
authors.forename: K
authors.initials: K
authors.lastname: Luze
authors.forename: U
authors.initials: U
authors.lastname: Schweigmann
authors.forename: P
authors.initials: P
authors.lastname: Schwärzler
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002585:Cesarean Section; D000075202:Contraindications; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects; D004008:Diclofenac / Q000009:adverse effects*; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging* / Q000187:drug effects*; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D016216:Ultrasonography, Prenatal
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004008:Diclofenac