title: Implications of new proteomics strategies for biology and medicine.
abstract: Advances in proteomics have fundamentally changed the paradigm of discovery for drug targets and novel biomarkers. Proteomics methodologies currently used will be reviewed in this paper, including structural proteomics, quantitative proteomics, and functional proteomics. A strategy to identify differentially expressed cell surface proteins as monoclonal therapeutic targets in oncology will be discussed.
authors.affiliation: Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA. bruno.domon@celera.com
authors.forename: Bruno
authors.initials: B
authors.lastname: Domon
authors.forename: Samuel
authors.initials: S
authors.lastname: Broder
mesh_terms: D001695:Biology / Q000379:methods; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002853:Chromatography, Liquid; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D008511:Medicine / Q000379:methods; D008956:Models, Chemical; D008967:Molecular Biology / Q000379:methods; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism; D020543:Proteome; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D014408:Biomarkers, Tumor; D020543:Proteome