title: Differences in spermatogenesis in cryptorchid testes among various strains of mice.
abstract: The purpose of the study reported here was to define strain differences in spermatogenesis in cryptorchid testes in mice. Mice of strains A/J, BALB/c, CBA/N, C3H/He, C57BL/6 (B6), ddY and ICR were found to be sensitive to heat stress attributable to experimentally induced cryptorchidism. In contrast, mice of strains AKR/N (AKR), MRL/MpJ-+/+ (M+) and MRL/MpJ-lpr/lpr (lpr) were resistant to heat stress. Relative increases of apoptotic cells were detected in the sensitive group, but not in the resistant group. A decrease of proliferating cell nuclear antigen-immunoreactive cells after experimentally induced cryptorchidism was observed only in the sensitive group. These results suggested that heat stress-resistant germ cells were present in MRL and AKR strains, possibly originating from the genetic background.
authors.affiliation: Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kazusa
authors.forename: Yuka
authors.initials: Y
authors.lastname: Namiki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Asano
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kon
authors.forename: Daiji
authors.initials: D
authors.lastname: Endoh
authors.forename: Takashi
authors.initials: T
authors.lastname: Agui
mesh_terms: D000818:Animals; D017209:Apoptosis; D003456:Cryptorchidism / Q000503:physiopathology*; D006358:Hot Temperature; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D013045:Species Specificity; D013091:Spermatogenesis; D013737:Testis / Q000166:cytology / Q000473:pathology / Q000503:physiopathology*