title: Hepatic haemangioendothelioma in adults: excellent outcome following liver transplantation.
abstract: Hepatic epithelioid haemangioendotheliomas (HEHEs) are rare, low-grade vascular tumours. Five adults with HEHEs and one adult with a vascular tumour showing combined features of haemangioma and haemangioendothelioma underwent liver transplantation. Two HEHE patients had extrahepatic metastases at the time of transplantation. Median survival time following diagnosis was 10.7 years (range 40 months to 195 months). One patient needed resection of a HEHE in the breast 13 years post-transplantation. All six patients are surviving free from disease 22 to 166 months after transplantation (median 77 months). One HEHE-patient who had been treated for 8 years for vertebral and cerebral localisations is free of disease without immunosuppression 56 months after transplantation. We can conclude that liver transplantation is a valuable treatment for hepatic haemangioendothelioma, even in cases of extrahepatic localisation of the disease.
authors.affiliation: Liver Transplant Programme, Department of Digestive Surgery, Cliniques Universitaires St-Luc/1400, Université Catholique de Louvain (UCL), Av. Hippocrate 10, 1200 Brussels, Belgium. lerut@ucl.chir.ac.be
authors.forename: Jan P
authors.initials: JP
authors.lastname: Lerut
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Orlando
authors.forename: Christine
authors.initials: C
authors.lastname: Sempoux
authors.forename: Olga
authors.initials: O
authors.lastname: Ciccarelli
authors.forename: Bernard E
authors.initials: BE
authors.lastname: Van Beers
authors.forename: Etienne
authors.initials: E
authors.lastname: Danse
authors.forename: Yves
authors.initials: Y
authors.lastname: Horsmans
authors.forename: Jacques
authors.initials: J
authors.lastname: Rahier
authors.forename: Francine
authors.initials: F
authors.lastname: Roggen
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome