The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.
Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c.2756A>G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis.
Linnebank
M
M
Department of Neurology, University Hospital of Bonn, Sigmund-Freud-Str. 25, Bonn D-53125, Germany. Michael.Linnebank@ukb.uni-bonn.de
Schmidt
S
S
Kölsch
H
H
Linnebank
A
A
Heun
R
R
Schmidt-Wolf
I G H
IG
Glasmacher
A
A
Fliessbach
K
K
Klockgether
T
T
Schlegel
U
U
Pels
H
H
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics* / Q000494:pharmacology; D000368:Aged; D016022:Case-Control Studies; D002471:Cell Transformation, Neoplastic; D016543:Central Nervous System Neoplasms / Q000235:genetics* / Q000473:pathology*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic
D004273:DNA, Neoplasm; D006710:Homocysteine; D005492:Folic Acid; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase