title: Diterpenes from the leaves of Croton zambesicus.
abstract: Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.
authors.affiliation: Laboratoire de Pharmacognosie, Unité CHAM, Université Catholique de Louvain, UCL 72.30-CHAM, Av. E. Mounier, 72, 1200 Bruxelles, Belgium.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Block
authors.forename: Chiara
authors.initials: C
authors.lastname: Baccelli
authors.forename: Bernard
authors.initials: B
authors.lastname: Tinant
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
authors.forename: Raoul
authors.initials: R
authors.lastname: Rozenberg
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Habib Jiwan
authors.forename: Gabriel
authors.initials: G
authors.lastname: Llabrès
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: De Pauw-Gillet
authors.forename: Joelle
authors.initials: J
authors.lastname: Quetin-Leclercq
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D029802:Croton / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes