title: Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones.
abstract: A variety of novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones have been synthesized by reacting (2-methylthio-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with a variety of amines, the starting material dithiocarbamate was synthesized from methylanthranilate. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. While the test compounds exhibited significant activity, the compounds A1, A2, A3 and A4 shown more potent analgesic activity, and the compound A4 shown more potent anti-inflammatory activity than the reference diclofenac sodium.
authors.affiliation: Medicinal Chemistry Laboratory, J.S.S. College of Pharmacy, Mysore, India. samy_veera@yahoo.com
authors.forename: Veerachamy
authors.initials: V
authors.lastname: Alagarsamy
authors.forename: Ramadoss
authors.initials: R
authors.lastname: Rajesh
authors.forename: Meena
authors.initials: M
authors.lastname: Ramaseshu
authors.forename: Sukumaran
authors.initials: S
authors.lastname: Vijaykumar
authors.forename: Kona Venkat
authors.initials: KV
authors.lastname: Ramseshu
authors.forename: Thirumoorthy
authors.initials: T
authors.lastname: Duraianandakumar
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines