The role of aflatoxin-contaminated food materials and HCV in developing hepatocellular carcinoma in Al-Sharkia Governorate, Egypt.
Aflatoxins, particularly aflatoxin B1 (AFB1) have been recognized as one of the most potent chemical carcinogen. In Egypt, HCV is prevalent. The progressive nature of HCV-related liver diseases was found to be influenced by other factors. In this paper, the role of aflatoxin contamination in the onset of liver cancer in HCV-infected patients was studied. The quantitative identification of the possible aflatoxins contamination in six urban and eleven rural areas using high performance liquid chromatography technique, revealed that corn, wheat, pea nut, lupine "termis", white rice, cowpea "lobiya", fava bean and brown rice showed the prevalence of AFB1 to be 64.7%, 53%, 53%, 47%, 47%, 41%, 29.4% & 29.4% respectively. A positive correlation was found between aflatoxin and positive HCV-PCR together with liver disease progression to G3S3, the indicative of hepatocellular carcinoma. Such correlation was not fully understood, but the oncogene amplification caused by HCV-infection may be aggravated by the consumption of aflatoxin contaminated raw food materials or their products.
Hifnawy
M S
MS
Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Mangoud
Amal M
AM
Eissa
Mostafa H
MH
Nor Edin
Essam
E
Mostafa
Yousry
Y
Abouel-Magd
Yousry
Y
Sabee
Essam I
EI
Amin
Ibrahem
I
Ismail
Alla
A
Morsy
Tosson A
TA
Mahrous
Seham
S
Afefy
Afefy F
AF
el-Shorbagy
Eman
E
el-Sadawy
Mohamoud
M
Ragab
Hosenia
H
Hassan
Mostafa I
MI
el-Hady
Gaber
G
Saber
Mohamoud
M
D000348:Aflatoxins / Q000009:adverse effects*; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology*; D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D005506:Food Contamination; D005516:Food Microbiology; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*
D000348:Aflatoxins