Polycythemia vera in a child following treatment for acute lymphoblastic leukemia.
Polycythemia vera (PV), a hematologic stem cell disorder characterized by predominant erythroid proliferation, is extremely rare in childhood. Some PV patients develop acute leukemia, especially acute myelogenous leukemia, but cases of PV occurring after treatment of acute leukemia are rare. The authors describe a girl with an atrioventricular canal who was diagnosed with acute lymphoblastic leukemia (ALL) at 23 months of age, was cured with chemotherapy, and developed PV 7 years later. She went on to develop hepatic complications of PV that culminated in death from liver disease at 20 years of age, without recurrence of ALL.
Sutherland
Nadia D
ND
Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32610-0296, USA.
Gonzalez-Peralta
Regino
R
Douglas-Nikitin
Vonda
V
Hunger
Stephen P
SP
D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001856:Bone Marrow Examination; D006502:Budd-Chiari Syndrome / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000150:complications; D011087:Polycythemia Vera / Q000139:chemically induced* / Q000150:complications / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D012074:Remission Induction
D000970:Antineoplastic Agents