title: Localized cutaneous leishmaniasis imported into Paris: a review of 39 cases.
abstract: BACKGROUND
  Localized cutaneous leishmaniasis (LCL) is a common cause of dermatosis in travelers returning from the tropics. We describe the epidemiological, clinical, and biological aspects and therapeutic outcome of imported LCL.
  
  
  METHODS
  A retrospective study of all cases of LCL observed from 1992 to 2000 in our tropical disease unit. Diagnosis was based on direct examination of skin smear and/or culture with identification of subsequent subspecies.
  
  
  RESULTS
  Thirty-nine cases (25 males, 14 females; median age: 38 years) were included: 35 French travelers and four foreign immigrants; 15 cases were acquired in the Old World and 24 cases in the New World. The patients presented to our department with a median of 60 days after return. Thirteen patients had already consulted general practitioners, and the diagnosis was missed in five cases (38%). Five clusters were identified. The median number of skin lesions was two per patient. Diagnosis was established by direct microscopic examination in 36 cases (92%). Thirty-five patients were assessable for first-line treatment with antimonials (intramuscularly in 18, intralesionally in nine), intramuscular pentamidine isethionate or oral ketoconazole (four patients each). Twenty-five patients (71.4%) were cured. The remaining 10 patients were cured after one to three courses of other treatments. Overall adverse events occurred in 60% of the patients treated with antimonials and 37% of those treated with pentamidine.
  
  
  CONCLUSIONS
  Imported LCL is still unrecognized by Western physicians. Clusters may be observed in groups of travelers. The therapeutic outcome is impaired by numerous but minor side-effects.
authors.affiliation: Service des Maladies Infectieuses et Tropicales and Service de Parasitologie et Mycologie, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: Lise
authors.initials: L
authors.lastname: El Hajj
authors.forename: Marc
authors.initials: M
authors.lastname: Thellier
authors.forename: Jean
authors.initials: J
authors.lastname: Carrière
authors.forename: François
authors.initials: F
authors.lastname: Bricaire
authors.forename: Martin
authors.initials: M
authors.lastname: Danis
authors.forename: Eric
authors.initials: E
authors.lastname: Caumes
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007273:Injections, Intramuscular; D016773:Leishmaniasis, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D010419:Pentamidine / Q000008:administration & dosage; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D014195:Travel; D016896:Treatment Outcome
chemical_list: D010419:Pentamidine