title: Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria.
abstract: BACKGROUND
  The gene encoding the dystrobrevin binding protein (DTNBP1) has been implicated in the pathogenesis of schizophrenia by several association studies. We tried to replicate these findings in a sample of 488 parent-proband trios recruited in Bulgaria. Probands had a diagnosis of schizophrenia (n = 441) or schizoaffective disorder (n = 47).
  
  
  METHODS
  We genotyped eight single nucleotide polymorphisms within the gene, four of which had been reported in previous studies, and four identified as informative by our group through direct screening of the gene and genotyping in a sample of cases and control subjects.
  
  
  RESULTS
  A significant excess of transmissions was observed for two of the markers, p1635 and p1757, (p =.0009 and.0013, respectively). Analysis of two-, three-, and four-marker haplotypes produced numerous positive results, with six (4% of the total combinations) at p <.001.
  
  
  CONCLUSIONS
  These results provide strong support for DTNBP1 as a susceptibility gene for schizophrenia; however, different haplotypes seem to be associated in different studies.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom.
authors.forename: George
authors.initials: G
authors.lastname: Kirov
authors.forename: Dobril
authors.initials: D
authors.lastname: Ivanov
authors.forename: Nigel M
authors.initials: NM
authors.lastname: Williams
authors.forename: Anna
authors.initials: A
authors.lastname: Preece
authors.forename: Ivan
authors.initials: I
authors.lastname: Nikolov
authors.forename: Radoi
authors.initials: R
authors.lastname: Milev
authors.forename: Svetlinka
authors.initials: S
authors.lastname: Koleva
authors.forename: Albena
authors.initials: A
authors.lastname: Dimitrova
authors.forename: Draga
authors.initials: D
authors.lastname: Toncheva
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
mesh_terms: D002031:Bulgaria / Q000208:ethnology; D002352:Carrier Proteins / Q000235:genetics*; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D010290:Parents; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins