title: N-terminal kinesins: many and various.
abstract: Molecular motors are a fascinating group of proteins that have vital roles in a huge variety of cellular processes. They all share the ability to produce force through the hydrolysis of adenosine triphosphate, and fall into classes groups: the kinesins, myosins and the dyneins. The kinesin superfamily itself can be split into three major groups depending on the position of the motor domain, which is localized N-terminally, C-terminally, or internally. This review focuses on the N-terminal kinesins, providing a brief overview of their roles within the cell, and illustrating recent key developments in our understanding of how these proteins function.
authors.affiliation: University of Manchester, School of Biological Sciences, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.
authors.forename: Marcin J
authors.initials: MJ
authors.lastname: Wozniak
authors.forename: Roy
authors.initials: R
authors.lastname: Milner
authors.forename: Viki
authors.initials: V
authors.lastname: Allan
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000737:chemistry* / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000145:classification / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D014780:Viruses / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D016547:Kinesins