Human papillomavirus type 16 viral load is higher in human immunodeficiency virus-seropositive women with high-grade squamous intraepithelial lesions than in those with normal cytology smears.
Human papillomavirus type 16 (HPV-16) viral load in cervicovaginal lavage samples collected from 66 human immunodeficiency virus-seropositive women was inversely correlated with blood CD4 count (P = 0.002). HPV-16 viral load was 81-fold higher in women with cervical smears suggestive of high-grade lesions (median, 4,425,883 copies/ micro g of DNA) than in women with normal smears (median, 54,576), controlling for age (P = 0.006).
Lefevre
Jonas
J
Laboratoire de Virologie Moléculaire, Centre de Recherche du Centre Hospitalier de l'Université de Montréal and Département de Microbiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
Hankins
Catherine
C
Money
Deborah
D
Rachlis
Anita
A
Pourreaux
Karina
K
Coutlée
François
F
D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006679:HIV Seropositivity / Q000150:complications* / Q000821:virology*; D006801:Humans; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology / Q000821:virology*; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000821:virology*; D019562:Viral Load; D002578:Uterine Cervical Dysplasia / Q000150:complications* / Q000473:pathology / Q000821:virology*
D017931:DNA Primers; D004279:DNA, Viral