title: Selectivity in the oligomerisation of G protein-coupled receptors.
abstract: G protein-coupled receptors can exist as dimers and/or higher order oligomers. Such quaternary structure appears central to their plasma membrane delivery and, potentially, to function. Recent evidence that these receptors can form hetero- as well as homo-dimers/oligomers has significant implications for pharmacology and pathophysiology. Knowledge of the basis and selectivity of GPCR hetero-dimerisation is thus vital. Current understanding of these areas is reviewed.
authors.affiliation: Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. g.milligan@bio.gla.ac.uk
authors.forename: Graeme
authors.initials: G
authors.lastname: Milligan
authors.forename: Juan
authors.initials: J
authors.lastname: Lopez-Gimenez
authors.forename: Shirley
authors.initials: S
authors.lastname: Wilson
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Carrillo
mesh_terms: D000818:Animals; D019281:Dimerization; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D043562:Receptors, G-Protein-Coupled