title: The impact of cardiopulmonary bypass on selenium status, thyroid function, and oxidative defense in children.
abstract: Selenium has important functions for oxidative defense and thyroid hormone metabolism. Selenium-dependent enzymes include 5'-iodothyronine deiodinase and glutathione peroxidase (GPX). The objective of this study was to investigate the relationship between plasma selenium, GPX activity, and thyroid hormone status in pediatric cardiac surgical patients. Plasma concentrations of selenium, free triiodothyronine (fT3), free thyroxin (fT4), and c-reactive protein as well as plasma activity of GPX were prospectively evaluated at anesthetic induction and 48 hours postoperatively in 59 children requiring cardiopulmonary bypass (CPB). GPX was measured at additional time points at 6, 12, and 24 hours postoperatively. There was a significant reduction in the plasma selenium concentration after cardiopulmonary bypass with obtained median measurements of 0.61 micromol/L (induction) and 0.51 micromol/L (48 hours postoperatively). The fT3/fT4 ratio decreased significantly from 0.28 at anesthetic induction to 0.22 at 48 hours postoperatively. There were no significant changes of GPX activity. 48 hours fT3 concentration, fT3/fT4 ratio, and selenium concentration were significantly negatively correlated with the time spent in intensive care. The concentration of plasma selenium in children undergoing cardiopulmonary bypass significantly decreases, resulting in diminished deiodinase activity, and a subsequent reduction in the conversion of T4 to T3.
authors.affiliation: Royal Liverpool Children's NHS Trust, Eaton Road, Liverpool L12 2AP, United Kingdom. Holzer@doctors.org.uk
authors.forename: R
authors.initials: R
authors.lastname: Holzer
authors.forename: B
authors.initials: B
authors.lastname: Bockenkamp
authors.forename: P
authors.initials: P
authors.lastname: Booker
authors.forename: P
authors.initials: P
authors.lastname: Newland
authors.forename: G
authors.initials: G
authors.lastname: Ciotti
authors.forename: M
authors.initials: M
authors.lastname: Pozzi
mesh_terms: D000293:Adolescent; D002097:C-Reactive Protein / Q000032:analysis; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012643:Selenium / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase; D012643:Selenium; D013974:Thyroxine