Stable hepatocyte transplantation using fibrin matrix.
Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups (transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.
Gwak
So-Jung
SJ
Department of Chemical Engineering, College of Engineering, Hanyang University, Seoul, Korea.
Choi
Dongho
D
Paik
Seung Sam
SS
Lee
Eun Yeol
EY
Lees
Kwang Soo
KS
Kim
Byung-Soo
BS
D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D005337:Fibrin; D022781:Hepatocytes / Q000637:transplantation*; D016031:Liver Transplantation / Q000379:methods; D051379:Mice; D023421:Models, Animal
D001672:Biocompatible Materials; D005337:Fibrin