title: Is quantitative interpretation likely to increase sensitivity of dobutamine stress echocardiography? A study of false-negative results.
abstract: BACKGROUND
  False-negative interpretations of dobutamine stress echocardiography (DSE) may be associated with reduced wall stress. Using measurements of contraction, we sought whether these segments were actually ischemic but unrecognized or showed normal contraction.
  
  
  METHODS
  We studied 48 patients (29 men; mean age 60 +/- 10 years) with normal regional function on the basis of standard qualitative interpretation of DSE. At coronary angiography within 6 months of DSE, 32 were identified as having true-negative and 16 as having false-negative results of DSE. Three apical views were used to measure regional function with color Doppler tissue, integrated backscatter, and strain rate imaging. Cyclic variation of integrated backscatter was measured in 16 segments, and strain rate and peak systolic strain was calculated in 6 walls at rest and peak stress.
  
  
  RESULTS
  Segments with false-negative results of DSE were divided into 2 groups with and without low wall stress according to previously published cut-off values. Age, sex, left ventricular mass, left ventricular geometric pattern, and peak workload were not significantly different between patients with true- and false-negative results of DSE. Importantly, no significant differences in cyclic variation and strain parameters at rest and peak stress were found among segments with true- and false-negative results of DSE with and without low wall stress. Stenosis severity had no influence on cyclic variation and strain parameters at peak stress.
  
  
  CONCLUSIONS
  False-negative results of DSE reflect lack of ischemia rather than underinterpretation of regional left ventricular function. Quantitative markers are unlikely to increase the sensitivity of DSE.
authors.affiliation: University of Queensland, Brisbane, Australia
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yuda
authors.forename: Zhi You
authors.initials: ZY
authors.lastname: Fang
authors.forename: Rodel
authors.initials: R
authors.lastname: Leano
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Marwick
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D025401:Echocardiography, Stress; D005188:False Negative Reactions; D005240:Feasibility Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity