[The parameters of the body immune reactivity in applying the therapeutic keratoplasty for the treatment of ocular burn lesions of extra severity].
One hundred and two (128 eyes) patients with stage 4 ocular burns underwent examinations. One-stage therapeutic keratoplasty was used in 67 (67.7%) patients. Retransplantation was made in 35 (34.3%) of patients due to graft rejection. According to the study, the more severe the clinical course of burn lesions is (cases that necessitated transplantation in the present research), the more pronounced changes are observed in the body immune reactivity of victims. In particular, the below peculiarities were observed: a progressing reduction of the contents of lymphocytes' and of B-lymphocytes; and a diminishing phagocytic activity of neutrophils in the peripheral blood registered at the terminal treatment stage in the patients after retransplantation versus the 1st-group patients with a more favorable clinical course. The compensatory increase of T-lymphocytes, T-helpers and of IgA, IgG was found to be less pronounced in group 2. A notably more intense sensitization response of the body to corneal antigens was established in the patients after retransplantation, which was a basis for using this index as a prognostication test in respect to the graft rejection crisis.
Chalanova
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RI
D002057:Burns, Chemical / Q000097:blood / Q000276:immunology* / Q000601:surgery*; D016039:Corneal Transplantation; D005126:Eye Burns / Q000097:blood / Q000139:chemically induced* / Q000276:immunology* / Q000601:surgery*; D005260:Female; D006084:Graft Rejection / Q000097:blood / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008214:Lymphocytes / Q000097:blood; D008297:Male; D012086:Reoperation
D007136:Immunoglobulins