title: [Pulmonary hyalinizing granuloma. Clinicopathologic study of 2 cases, with some original ultrastructural observations and review of the literature].
abstract: OBJECTIVE
  To report the clinical, histological, immunohistochemical and ultrastructural features of 2 new cases of pulmonary hyalinizing granuloma.
  
  
  RESULTS
  Both patients were males: one, 72-year-old with retroperitoneal fibrosis, was asymptomatic, while the other, 67-year-old, presented with non productive cough. In both cases, a chest x-ray showed a solitary pulmonary nodule. Microscopically, the nodules were well circumscribed and composed of lamellae of hyalinized collagen. At the periphery, a more cellular rim consisting of lymphocytes, plasma cells and myofibroblasts was present. Immunohistochemical and ultrastructural examinations revealed myofibroblastic elements actively synthesizing collagen fibrils.
authors.affiliation: Unità Operative di Pneumologia, Università di Modena.
authors.forename: G
authors.initials: G
authors.lastname: Vezzani
authors.forename: A
authors.initials: A
authors.lastname: Cavazza
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Pasquinelli
authors.forename: P
authors.initials: P
authors.lastname: Avanzini
authors.forename: S
authors.initials: S
authors.lastname: Asioli
authors.forename: S
authors.initials: S
authors.lastname: Piana
authors.forename: M
authors.initials: M
authors.lastname: Chilosi
mesh_terms: D000368:Aged; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D016726:Plasma Cell Granuloma, Pulmonary / Q000378:metabolism / Q000473:pathology*