Combinatorial synthesis of substituted biaryls and heterocyclic arylamines.
In this paper, we report very general conditions that enable palladium-mediated coupling reactions on the solid support. A wide variety of biaryls and arylamines (including pyrimidines) have been synthesized using this protocol. The chemistry facilitates a combinatorial approach to the production of large numbers of medicinally relevant heterocyclic structures.
Ma
Yao
Y
NeoGenesis Pharmaceuticals, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139, USA. yaoma@neogenesis.com
Margarida
Laura
L
Brookes
Jeseca
J
Makara
Gergely M
GM
Berk
Scott C
SC