title: Nodal signaling: CrypticLefty mechanism of antagonism decoded.
abstract: The secreted TGFbeta factor Lefty antagonizes Nodal signaling during vertebrate embryogenesis, but how it does so has been a mystery. Recent analyses have elucidated the molecular mechanisms underlying this function of Lefty.
authors.affiliation: Huntsman Cancer Institute Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA.
authors.forename: William W
authors.initials: WW
authors.lastname: Branford
authors.forename: H Joseph
authors.initials: HJ
authors.lastname: Yost
mesh_terms: D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D055458:Left-Right Determination Factors; D055457:Nodal Protein; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors* / Q000378:metabolism* / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*
chemical_list: D006023:Glycoproteins; D055458:Left-Right Determination Factors; D055457:Nodal Protein; D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor