New highly selective inhibitors of class II fructose-1,6-bisphosphate aldolases.
Phosphoglycolo amidoxime and phosphoglycolo hydrazide, two new derivatives of phosphoglycolic acid, were synthesised and successfully tested as selective competitive inhibitors of class II FBP-aldolases.
Fonvielle
Matthieu
M
Laboratoire de Chimie Bioorganique et Bioinorganique, Institut de Chimie Moléculaire et de Matériaux d'Orsay, CNRS UMR 8124, Université Paris-Sud, F-91405 Orsay, France.
Weber
Philippe
P
Dabkowska
Kasia
K
Therisod
Michel
M
D000818:Animals; D001412:Bacillus subtilis / Q000201:enzymology; D001426:Bacterial Proteins; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors*; D005656:Fungal Proteins; D006834:Hydrazines / Q000138:chemical synthesis / Q000494:pharmacology*; D007700:Kinetics; D018482:Muscle, Skeletal / Q000201:enzymology; D010091:Oximes / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D006834:Hydrazines; D010091:Oximes; D005634:Fructose-Bisphosphate Aldolase