title: [Surgery for diaphragmatic palsy].
abstract: Diaphragmatic palsy leads to a permanent ascension of one or both hemi-diaphragms with highly variable functional impact. The underlying mechanisms can be divided into two main categories: neurological or muscular disorder leading to peripheral dysfunction; defective or non-transmitted central command causing central dysfunction. A complete morphological and functional work-up is required to determine the circumstances leading to diaphragmatic palsy and the uni- or bilateral nature of the paralysis. The entire phreno-diaphragmatic transmission chain from the cranium to the diaphragmatic muscle must be analyzed to search for a local cause. Function tests are used to examine central command and transmission, function of the phrenic nerve, and the capacity of the diaphragmatic muscle to generate sufficient pressure for efficacious ventilation. Once indirect causes of diaphragmatic ascension (independent of the phreno-diaphragmatic system) have been ruled out, surgery may be proposed for symptomatic, permanent and irreversible diaphragmatic paralysis. A tension procedure may be sufficient in the event of eventration with or without phrenic palsy. For well-selected patients with central paralysis due to supraspinal lesions with intact nerves and muscles, implantation of a phrenic pacemaker may be helpful to eliminate positive pressure mechanical ventilation and restore more physiological respiration.
authors.affiliation: Service de Chirurgie Thoracique, Hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris. françoise.le-pimpec-barthes@hop.egp.ap-hop-paris.fr
authors.forename: F
authors.initials: F
authors.lastname: Le Pimpec-Barthes
authors.forename: M
authors.initials: M
authors.lastname: Arab
authors.forename: M
authors.initials: M
authors.lastname: Debieche
mesh_terms: D003964:Diaphragm / Q000294:innervation; D007839:Functional Laterality; D006801:Humans; D018579:Patient Selection; D010791:Phrenic Nerve / Q000473:pathology / Q000601:surgery*; D012133:Respiratory Paralysis / Q000601:surgery*