Assembly of kinetochores in vertebrate cells.
The centromere is a specialized region of each chromosome that is essential for faithful chromosome segregation during mitosis and meiosis in eukaryotic cells. Centromeres are the site at which kinetochores are formed. The kinetochore is responsible for microtubule binding and chromosome movement. In this review, I will focus on recent advances in our understanding of centromere DNAs as sites for kinetochore assembly and the mechanism underlying kinetochore assembly in vertebrate cells.
Fukagawa
Tatsuo
T
PRESTO, the Japan Science and Technology Agency (JST), National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411-8540, Japan. tfukagawa@lab.nig.ac.jp
D000818:Animals; D002503:Centromere / Q000737:chemistry / Q000648:ultrastructure; D005057:Eukaryotic Cells / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D018386:Kinetochores / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D009687:Nuclear Proteins / Q000378:metabolism; D014714:Vertebrates
D009687:Nuclear Proteins