Identification of a new allele, HLA-DRB1*1360, on a DRB5 haplotype in a Brazilian individual.
The application of DNA-based methods for human leukocyte antigen (HLA) genotyping has revealed an ever-increasing degree of polymorphism within the HLA-DRB loci and has resulted in the discovery of new alleles. We have identified a new DRB1 allele that was subsequently named DRB1*1360 by the WHO Nomenclature Committee. This allele is unusual for a DRB1*13 allele, as it is present on a DRB5 haplotype rather than the normal DRB3 haplotype found in association with DRB1*13 alleles.
Testa
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GV
Laboratory of Histocompatibility, Hemotherapy Center, University of Campinas, Campinas, Brazil. gvt@obelix.unicamp.br
Bunce
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M
Sheldon
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MH
Dunn
P P J
PP
Day
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S
Marques
S B D
SB
D001483:Base Sequence; D001938:Brazil; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D059847:HLA-DRB5 Chains; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data; D017385:Sequence Homology
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C495084:HLA-DRB1*13:60 antigen; D059847:HLA-DRB5 Chains