Breaking up is easy to do (if you're a DNA enzyme that cleaves RNA).
In this issue of Chemistry & Biology, Cruz et al. use in vitro selection to select deoxyribozymes that collectively cleave almost any RNA dinucleotide junction. More remarkable is the finding that the new enzymes are related to the 8-17 deoxyribozyme that cleaves AG dinucleotide junctions.
Silverman
Scott K
SK
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana 61801, USA.
D021881:DNA, Catalytic / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D012313:RNA / Q000378:metabolism*
D021881:DNA, Catalytic; D012313:RNA