Clinical implications of E-cadherin associated hereditary diffuse gastric cancer.
Approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. These may be of the diffuse or intestinal type. Linkage analysis has recently implicated E-cadherin mutations in an estimated 25% of families with an autosomal dominant predisposition to diffuse type gastric cancers. This subset of gastric cancer has been termed hereditary diffuse gastric cancer (HDGC).
Fitzgerald
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RC
Hutchison/MRC Research Centre, Cambridge, UK. rcf@hutchison-mrc.cam.ac.uk
Caldas
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D015820:Cadherins / Q000235:genetics*; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
D015820:Cadherins