title: Possible horizontal transmission of crimean-congo hemorrhagic Fever virus from a mother to her child.
abstract: The case of a child with Crimean-Congo hemorrhagic fever (CCHF) presumably infected with CCHF virus from her 27-year-old mother is described. The mother with CCHF was treated with ribavirin and did not present with any symptoms of obvious hemorrhage. The child developed fever on the 5th day after the mother's onset. The partial virus genome was amplified by RT-PCR, and nested PCR from the child and the genome sequence were identical to that from the mother, indicating possible transmission of the virus from mother to child. This case indicates the importance of preventive measures for in-house outbreaks of CCHF.
authors.affiliation: Special Pathogens Laboratory, Department of Virology I, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saijo
authors.forename: Qing
authors.initials: Q
authors.lastname: Tang
authors.forename: Bawudong
authors.initials: B
authors.lastname: Shimayi
authors.forename: Lei
authors.initials: L
authors.lastname: Han
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Zhang
authors.forename: Muer
authors.initials: M
authors.lastname: Asiguma
authors.forename: Dong
authors.initials: D
authors.lastname: Tianshu
authors.forename: Akihiko
authors.initials: A
authors.lastname: Maeda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kurane
authors.forename: Shigeru
authors.initials: S
authors.lastname: Morikawa
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D002675:Child, Preschool; D002681:China; D018562:Disease Transmission, Infectious; D005260:Female; D003225:Hemorrhagic Fever Virus, Crimean-Congo / Q000235:genetics / Q000302:isolation & purification*; D006479:Hemorrhagic Fever, Crimean / Q000188:drug therapy / Q000635:transmission* / Q000821:virology; D006801:Humans; D009035:Mothers; D012367:RNA, Viral / Q000032:analysis / Q000097:blood; D012254:Ribavirin / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D012254:Ribavirin