Transfusion-associated HIV infection in Mexico related to paid blood donors; HIV epidemic.
The objective of the study was to describe the clinical, epidemiological profile and conditional incubation period in a group of transfusion-associated HIV-infected (TAHI) patients seen in five national tertiary care centres in Mexico from 1983 to April 1998. Date of transfusions, AIDS diagnoses, opportunistic infections and malignancies were collected. The incubation period was estimated through a non-parametric conditional analysis. One hundred and fifty-seven TAHI cases were analysed. The frequency of TAHI by year of transfusion was: 0.6% in 1980 and 1981, 4.5% in 1984, 22.4% in 1985, 54.5% in 1986, 10.3% in 1987, 0.6% in 1988, 1.9% in 1989 and 1990, 1.3% in 1993 and 0.6% in 1994 and 1996. The median incubation period was 4.3 years. A well-defined epidemic period of HIV-infection among blood-recipients was identified that coincided with the HIV-epidemic among paid donors. TAHI patients in Mexico developed AIDS in a shorter time than that described for other populations.
Volkow
Patricia
P
Instituto Nacional de Cancerología, Departamento de Enfermedades Infecciosas, Av. San Fernando #22, México DF CP 14080. volkow@infosel.net.mx
Velasco
Silvia Ruiz
SR
Mueller
Nancy
N
Ponce de Leon
Samuel
S
Sierra-Madero
Juan Gerardo
JG
Sada
Eduardo
E
Soto
José Luis
JL
Perez-Ancona
Franz
F
Ruiz-Palacios
Guillermo
G
Castillo
José Ramón
JR
Mohar
Alejandro
A
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000635:transmission; D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D019992:Databases as Topic; D004196:Disease Outbreaks; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D013997:Time Factors; D065227:Transfusion Reaction