MicroRNA precursors in motion: exportin-5 mediates their nuclear export.
The discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).
Kim
V Narry
VN
School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea. narrykim@snu.ac.kr
D021581:Active Transport, Cell Nucleus / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D028884:Karyopherins / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D028961:beta Karyopherins / Q000235:genetics / Q000378:metabolism*; D020931:ran GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
D028884:Karyopherins; D035683:MicroRNAs; D009687:Nuclear Proteins; C446511:XPO5 protein, human; D028961:beta Karyopherins; D020931:ran GTP-Binding Protein