title: Eletriptan for the short-term prophylaxis of cluster headache.
abstract: BACKGROUND
  A beneficial prophylactic effect from eletriptan 40 mg given to a single patient with cluster headache was observed.
  
  
  OBJECTIVE
  To further evaluate the efficacy of eletriptan in the short-term prophylaxis of cluster headache.
  
  
  METHODS
  We treated 18 patients; mean age, 40.5 years (standard deviation [SD], 9.9). The number of cluster headache attacks was recorded during a baseline period of 6 days, and during 6 days of treatment with eletriptan 40 mg twice daily. The primary outcome measure was the reduction in the number of attacks during the treatment period.
  
  
  RESULTS
  In the 16 patients who completed the study (2 patients were lost to follow-up), the mean total number of attacks decreased from 10.9 (SD, 5.6) during baseline to 6.3 (SD, 3.7) during treatment with eletriptan (P=.01) The reduction in the number of attacks exceeded 50% in 6 patients.
  
  
  CONCLUSIONS
  This small open-label study suggests that eletriptan 40 mg twice daily may be useful for the short-term prophylaxis of cluster headache.
authors.affiliation: Department of Neurology, University of Vienna (Austria) Medical School.
authors.forename: Karin
authors.initials: K
authors.lastname: Zebenholzer
authors.forename: Christian
authors.initials: C
authors.lastname: Wöber
authors.forename: Marion
authors.initials: M
authors.lastname: Vigl
authors.forename: Peter
authors.initials: P
authors.lastname: Wessely
mesh_terms: D000328:Adult; D003027:Cluster Headache / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011759:Pyrrolidines / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014363:Tryptamines
chemical_list: D007211:Indoles; D011759:Pyrrolidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C115647:eletriptan