Nodal signaling: CrypticLefty mechanism of antagonism decoded.
The secreted TGFbeta factor Lefty antagonizes Nodal signaling during vertebrate embryogenesis, but how it does so has been a mystery. Recent analyses have elucidated the molecular mechanisms underlying this function of Lefty.
Branford
William W
WW
Huntsman Cancer Institute Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA.
Yost
H Joseph
HJ
D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D055458:Left-Right Determination Factors; D055457:Nodal Protein; D015398:Signal Transduction / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors* / Q000378:metabolism* / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*
D006023:Glycoproteins; D055458:Left-Right Determination Factors; D055457:Nodal Protein; D016212:Transforming Growth Factor beta; D004815:Epidermal Growth Factor