title: Sinus node function in patients with Brugada-type ECG.
abstract: BACKGROUND
  Some studies have shown that patients with Brugada syndrome (BS) have atrioventricular conduction disturbance, but their sinus node function has not been evaluated.
  
  
  RESULTS
  The patients group consisted of 59 male patients and 1 female patient with BS. Supraventricular and ventricular programmed electrical stimulation (PES) was performed. Ventricular fibrillation (VF) or sustained polymorphic ventricular tachycardia was induced by ventricular PES in 26 patients with BS (VF group), but was not induced in the other 34 patients (non-VF group). Sinus node function and conduction of the atrioventricular (AV) node in the control group, non-VF group and VF group were evaluated. Sinus node function was attenuated and the His - ventricle interval was prolonged in the VF group (corrected sinus node recovery time: 452+/-126 ms (VF group), 324+/-146 ms (non-VF group), Sino-atrial conduction time: 179+/-60 ms (VF group), 127+/-60 ms (non-VF group), His-ventricle interval: 41+/-9 ms (VF group), 35+/-8 ms (non-VF group)).
  
  
  CONCLUSIONS
  The function of both the sinus node and AV node are attenuated in patients with PES-induced VF.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Okayama, Japan. hmorita@cc.okayama-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Kengo
authors.initials: K
authors.lastname: Fukushima-Kusano
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagase
authors.forename: Kohei
authors.initials: K
authors.lastname: Miyaji
authors.forename: Shigeki
authors.initials: S
authors.lastname: Hiramatsu
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Banba
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishii
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Watanabe
authors.forename: Mikio
authors.initials: M
authors.lastname: Kakishita
authors.forename: Shiho
authors.initials: S
authors.lastname: Takenaka-Morita
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hironori
authors.initials: H
authors.lastname: Saito
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Emori
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000328:Adult; D001283:Atrioventricular Node / Q000503:physiopathology; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D011930:Reaction Time; D012849:Sinoatrial Node / Q000503:physiopathology*; D017180:Tachycardia, Ventricular / Q000209:etiology; D014693:Ventricular Fibrillation / Q000209:etiology