SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors.
Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking members of the SLAM family of receptors. The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions.
Veillette
André
A
Laboratory of Molecular Oncology, Clinical Research Institute on Montreal, Québec, Canada. veillea@ircm.qc.ca
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007109:Immunity; D007694:Killer Cells, Natural / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D011971:Receptors, Immunologic / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
D011971:Receptors, Immunologic