[A case of Barrett's esophageal carcinoma successfully treated with TS-1 in an elderly patient].
A 92-year-old man was admitted to the hospital for rehabilitation. Upper gastrointestinal endoscopy was performed 2 weeks after admission because of vomiting which was found to be due to a Barrett's esophageal carcinoma at the lower esophagus. We chose chemotherapy with TS-1 at the dose of 50 mg/day in consideration of his age and performance status. His difficulty in swallowing disappeared rapidly. After 7 days of treatment, grade 3 anorexia appeared, so the dosage of TS-1 was reduced to 25 mg/day. After the reduction of TS-1, anorexia soon disappeared. The regimen consisted of TS-1 every 6 weeks as 1 cycle. After 7 cycles of treatment, upper gastrointestinal endoscopy and upper gastrointestinal series revealed that the tumor had a completely disappeared. The effects of chemotherapy were judged as CR. This case suggests that administration of TS-1 is an effective choice of chemotherapy not only for gastric carcinoma but also Barrett's esophageal carcinoma.
Imazu
Hiroki
H
Dept. of Surgery, Fujita Health University, School of Medicine.
Ochiai
Masahiro
M
Sakurai
Yoichi
Y
Komori
Yoshiyuki
Y
Uyama
Ichiro
I
Matsubara
Toshiki
T
Hasegawa
Shigeru
S
Nakamura
Yasuko
Y
Syoji
Mitsutaka
M
Yoshida
Ikuo
I
Masui
Toshihiko
T
Tonomura
Syuhei
S
Nagai
Kichizou
K
Hattori
Hideaki
H
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001471:Barrett Esophagus / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use*
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid