title: Effect of cooling and re-warming on cerebral and whole body electrical impedance.
abstract: Cerebral electrical impedance is useful for the detection of cerebral edema following hypoxia in newborn infants. Thus it may be useful for determining neurological outcome or monitoring treatment. Hypothermia is a promising new therapy currently undergoing trials, but will alter impedance measurements. This study aimed to define the relationship between temperature and both cerebral and whole body electrical impedance, and to derive correction factors for adjustment of impedance measurements during hypothermia. In eight anaesthetized 1-2 day old piglets rectal, tympanic and scalp temperatures were monitored continuously. Following baseline readings at a rectal temperature of 39 degrees C, piglets were cooled to 32 degrees C. Four piglets were re-warmed. Cerebral and whole body impedance were measured at each 0.5 degrees C as rectal temperature decreased. There was a strong linear relationship between both cerebral and whole body impedance and each of the temperatures measured. There was no difference in the relationship between impedance and rectal, tympanic or scalp temperatures. The relationship for impedance and rectal temperature was the same during cooling and re-warming. Using the correction factors derived it will be possible to accurately monitor cerebral and whole body fluid distribution during hypothermic treatment.
authors.affiliation: Perinatal Research Centre, University of Queensland, Royal Brisbane and Women's Hospital, Herston, 4029 Queensland, Australia. b.lingwood@uq.edu.au
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Lingwood
authors.forename: Kimble R
authors.initials: KR
authors.lastname: Dunster
authors.forename: Genevieve N
authors.initials: GN
authors.lastname: Healy
authors.forename: Paul B
authors.initials: PB
authors.lastname: Colditz
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001831:Body Temperature / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D017097:Electric Impedance; D007036:Hypothermia, Induced / Q000379:methods*; D017694:Rewarming / Q000379:methods*; D013552:Swine