Testicular germ cell tumour presenting as thyrotoxicosis.
A case is reported of a patient who presented to his family doctor with a short history of cough with signs and symptoms of thyrotoxicosis. Carbimazole treatment had little effect and his symptoms worsened to include severe shortness of breath. He was investigated further and found to have multiple lung and liver metastases from an unknown primary site. Biopsy and subsequent post-mortem investigations revealed a testicular tumour and a grossly elevated serum human chorionic gonadotrophin (hCG) concentration. The biochemical and clinical thyrotoxicosis is presumed to be due to the thyrotrophic activity of excess hCG secretion, in a situation analogous to that seen in hydatidiform mole or in hyperemesis gravidarum.
Tilbrook
L K
LK
Department of Clinical Biochemistry, Broomfield Hospital, Mid Essex Hospital Services, NHS Trust Broomfield, Chelmsford CM1 5ET, Essex, UK. Louise.Tilbrook@meht.nhs.uk
Slater
J
J
Blainey
A D
AD
D013956:Antithyroid Agents / Q000009:adverse effects / Q000494:pharmacology; D002231:Carbimazole / Q000009:adverse effects / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000097:blood / Q000502:physiology; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood / Q000503:physiopathology; D006939:Hyperemesis Gravidarum / Q000097:blood / Q000503:physiopathology; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000503:physiopathology*; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects*; D013736:Testicular Neoplasms / Q000503:physiopathology*; D013971:Thyrotoxicosis / Q000097:blood / Q000209:etiology*
D013956:Antithyroid Agents; D006063:Chorionic Gonadotropin; D002231:Carbimazole