Transcriptional regulation of the TRAIL-R3 gene.
TRAIL-R3 is a decoy receptor for TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), a member of the tumor necrosis factor (TNF) ligand family. TRAIL induces apoptosis in a broad range of cancer cell lines, but not in many normal cells-a finding that generated extraordinary excitement about its potential as a specific antitumor agent. In several cell types, decoy receptors inhibit TRAIL-induced apoptosis by binding to it and preventing its binding to TRAIL proapoptotic or death receptors. However, recently published data regarding the role of these receptors in TRAIL-induced cellular death are contradictory. The key to resolving this controversy may lie in the regulation and cellular localization of TRAIL receptors. In this regard, cloning and analysis of the TRAIL-R3 promoter will help to identify the cellular factors that regulate its transcriptional expression. This chapter summarizes current knowledge in this field and outlines directions for future research.
Ruiz de Almodóvar
Carmen
C
Department of Cellular Biology and Immunology Instituto de Parasitología y Biomedicina Consejo Superior de Investigaciones Cientificas Granada E-18001, Spain.
López-Rivas
Abelardo
A
Redondo
Juan Miguel
JM
Rodríguez
Antonio
A
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D058851:GPI-Linked Proteins; D005786:Gene Expression Regulation; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics* / Q000502:physiology; D053320:Receptors, Tumor Necrosis Factor, Member 10c; D053221:TNF-Related Apoptosis-Inducing Ligand; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D058851:GPI-Linked Proteins; D008562:Membrane Glycoproteins; D018124:Receptors, Tumor Necrosis Factor; D053320:Receptors, Tumor Necrosis Factor, Member 10c; D053221:TNF-Related Apoptosis-Inducing Ligand; C108661:TNFRSF10C protein, human; C505653:TNFSF10 protein, human; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha; D004247:DNA