title: Posterior capsule opacification after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM lenses: one-year results of an intraindividual comparison multicenter study.
abstract: OBJECTIVE
  To perform an intraindividual comparison of posterior capsule opacification (PCO) with 2 foldable intraocular lenses (IOLs) and a foldable acrylic IOL 1 year after in-the-bag implantation.
  
  
  METHODS
  Seven German ophthalmology centers.
  
  
  METHODS
  In an open prospective randomized multicenter study, each center intraindividually compared a high-refractive-index, sharp-edged optic silicone IOL (CeeOn Edge 911A, Pharmacia) with a high-refractive-index, round-edged optic silicone IOL (PhacoFlex SI-40NB, Allergan) or a sharp-edged optic acrylic IOL (AcrySof MA60BM, Alcon). Of 288 randomized patients, 247 had standard phacoemulsification with in-the-bag IOL implantation in both eyes by the same surgeon. One eye of each patient received a CeeOn Edge IOL and the fellow eye, an AcrySof or PhacoFlex IOL. A morphologic evaluation of PCO was performed using the Evaluation of Posterior Capsule Opacification (EPCO) system 1 to 2 weeks and 11 to 14 months after surgery. The digital pictures were evaluated by an independent investigator who was blind to the type of IOL. Intraindividual differences in EPCO scores were statistically evaluated by a 1-sided binomial test at an alpha-level of 5%.
  
  
  RESULTS
  One year after surgery, 127 patients with the AcrySof IOL and 102 patients with the PhacoFlex IOL in the control eye were reexamined. Functional results, safety, and handling were not significantly different between the 3 IOLs. All reexamined eyes had a very low PCO grade. The EPCO values revealed less PCO in eyes with the CeeOn Edge IOL than in eyes with the AcrySof or PhacoFlex IOL, but the difference was not statistically significant. A neodymium:YAG laser capsulotomy was performed in 1 eye with a CeeOn Edge IOL, 1 eye with an AcrySof IOL, and 2 eyes with a PhacoFlex IOL.
  
  
  CONCLUSIONS
  The EPCO PCO grade was low 1 year after implantation of CeeOn Edge 911A, PhacoFlex SI-40NB, and AcrySof MA60BM IOLs; there was no statistically significant difference between the IOLs. The impact of IOL material and edge design on PCO development might be relevant in a long-term follow-up of this study.
authors.affiliation: Department of Ophthalmology, Bundesknappschaft's Hospital, Sulzbach, Germany. Mester@kksulzbach.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mester
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Fabian
authors.forename: Ralf
authors.initials: R
authors.lastname: Gerl
authors.forename: Wilfried
authors.initials: W
authors.lastname: Hunold
authors.forename: Werner
authors.initials: W
authors.lastname: Hütz
authors.forename: Jürgen
authors.initials: J
authors.lastname: Strobel
authors.forename: Heike
authors.initials: H
authors.lastname: Hoyer
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohnen
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D001672:Biocompatible Materials; D002386:Cataract / Q000209:etiology*; D005260:Female; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D012826:Silicone Elastomers
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; D012826:Silicone Elastomers