title: Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the risk of pancreatic cancer death.
abstract: Recent epidemiological studies have shown that high serum levels of insulin-like growth factor-I (IGF-I) are associated with an increased risk of lung, colon, breast and prostate cancer. Since very few studies have addressed the role of serum levels of IGF-I in the development of pancreatic cancer, we conducted a nested case-control study to examine this association. The analysis involved 69 case subjects who died from pancreatic cancer during the follow-up period of the study, and 207 control subjects matched for sex, age(+/-1 year) and study area, selected randomly from a cohort of 10364 individuals. Serum levels of IGF-I and IGF binding protein-3 (IGFBP-3) were measured by immunoradiometric assay, using commercially available kits. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using conditional logistic models. The levels of IGF-I were positively correlated with IGFBP-3 (r=0.55). There was a positive, but statistically insignificant association between serum levels of IGF-I and risk of death from pancreatic cancer, with subjects in the highest quartile having an OR of 2.31 (95% CI=0.70-2.64) compared to those in the lowest quartile. The risk of pancreatic cancer death increased significantly with increasing serum levels of IGFBP-3 (trend p=0.03). Further adjustment for IGFBP-3 or IGF-I slightly attenuated the positive associations. This nested case-control study showed that high serum levels of IGF-I and IGFBP-3 may be associated with an increased risk of death from pancreatic cancer.
authors.affiliation: Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan.
authors.forename: Yingsong
authors.initials: Y
authors.lastname: Lin
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Yagyu
authors.forename: Yuki
authors.initials: Y
authors.lastname: Obata
authors.forename: Teruo
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inaba
authors.forename: Michiko
authors.initials: M
authors.lastname: Kurosawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Motohashi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ohno
mesh_terms: D000368:Aged; D015992:Body Mass Index; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000401:mortality*; D012306:Risk
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I