The short-term effects of anti-tuberculosis therapy on plasma pyridoxine levels in patients with pulmonary tuberculosis.
Plasma levels of pyridoxal phosphate (PLP) were determined in 20 patients with pulmonary tuberculosis before and after one week of drug therapy including isoniazid. At baseline, body mass index and PLP levels were reduced in 10 and 18 patients, respectively. After 7 days of therapy, PLP levels decreased (P < 0.001) in all but one subject who inadvertently received pyridoxine supplementation. The decreased PLP levels occurred despite a significant improvement in the acute phase response (increased albumin [P < 0.001] and reduced C-reactive protein levels [P < 0.01]). This study indicates the need for possible routine pyridoxine supplementation in patients with newly diagnosed tuberculosis.
Visser
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ME
Nutrition and Dietetics Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa. elime@telkomsa.net
Texeira-Swiegelaar
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C
Maartens
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D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004977:Ethambutol / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood / Q000150:complications; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D011718:Pyrazinamide / Q000494:pharmacology / Q000627:therapeutic use; D011736:Pyridoxine / Q000097:blood*; D012293:Rifampin / Q000494:pharmacology / Q000627:therapeutic use; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000150:complications / Q000188:drug therapy
D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D011736:Pyridoxine; D007538:Isoniazid; D012293:Rifampin