Surface modification of UHMWPE for use in total joint replacements.
To create a hydrophilic, lubricious, more wear-resistant UHMWPE bearing, a novel hyaluronan (HA) derivative and novel UHMWPE-hyaluronan composite were developed. HA was silylated to increase its hydrophobicity and compatibility with UHMWPE. The sily1 HA rapidly diffused into the connected pores of UHMWPE preforms in xylenes solution, and fixed within UHMWPE and on its surface after crosslinking. A micro-composite was obtained after hot-pressing the porous preform. The presence of HA film on the composite surface has been demonstrated through X-Ray photoelectron spectroscopy (XPS) analysis and Toluidine Blue O (TBO) dye assay. The aqueous contact angles of micro-composite samples were significantly lower compared with UHMWPE control samples, and the samples processed with hydrolysis prior to final molding were superior to those processed with hydrolysis after molding.
Zhang
Min
M
Department of Mechanical Engineering, Biomedical Engineering Program, Colorado State University, Fort Collins, CO 80523-1374, USA.
James
Susan P
SP
King
Richard
R
Beauregard
Guy
G
D019544:Equipment Failure Analysis; D006244:Hardness; D006820:Hyaluronic Acid / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007595:Joint Prosthesis; D008153:Lubrication; D008420:Manufactured Materials; D008422:Materials Testing; D008968:Molecular Conformation; D011095:Polyethylenes / Q000737:chemistry*; D013499:Surface Properties
D011095:Polyethylenes; C111601:ultra-high molecular weight polyethylene; D006820:Hyaluronic Acid