Single footshock attenuates c-Fos expression induced by 5-HT2A receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in rat brain.
Administration of 3 mg/kg 5-hydroxytryptamine2A/2C (5-HT2A/2C) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) induced c-Fos expression in all areas of the rat neocortex. The single footshock 24 h before DOI administration significantly attenuated DOI-induced c-Fos expression in layer IV of the primary somatosensory cortex. These changes in c-Fos expression suggest an adaptational change in the somatosensory cortex by acute stress.
Izumi
Takeshi
T
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Neural Function, North 15, West 7, Sapporo 060-8638, Sapporo, Japan. tizumi@med.hokudai.ac.jp
Kitaichi
Yuji
Y
Nakagawa
Shin
S
Inoue
Takeshi
T
Koyama
Tsukasa
T
D000662:Amphetamines / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D002452:Cell Count / Q000379:methods; D004597:Electroshock; D005528:Foot / Q000294:innervation / Q000528:radiation effects*; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D000662:Amphetamines; D016760:Proto-Oncogene Proteins c-fos; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine