Modal gating of NMDA receptors.
The decay time course of excitatory postsynaptic currents generated by slow glutamatergic synapses is determined by the single-channel kinetics of postsynaptic NMDA receptor channels. In a recent study, examination of these single-channel kinetics has revealed that NMDA receptors can enter into modal gating. Linear free-energy analysis suggests that the various modes arise from a common reaction mechanism, providing further insight into the gating underlying decay of the slow synaptic response.
Magleby
Karl L
KL
Department of Physiology and Biophysics, University of Miami School of Medicine, PO Box 016430, Miami, FL 33101-6430, USA. kmagleby@miami.edu
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology*; D007700:Kinetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate