title: Oxidative C-C bond-forming reaction of electron-rich alkylbenzyl ether with trimethylvinyloxysilane.
abstract: Treatment of an electron-rich benzyl ether with DDQ at ambient temperature followed by addition of a silyl enol ether undergoes a C-C bond-forming reaction to afford 3-alkoxy-3-phenyl-propionyl compound. This is a general reaction and works well with a variety of silyl enol ethers to give carbonyl products in yields ranging from 10 to 85%.
authors.affiliation: Discovery Chemistry Research, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.
authors.forename: Bai-Ping
authors.initials: BP
authors.lastname: Ying
authors.forename: Bridget G
authors.initials: BG
authors.lastname: Trogden
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Kohlman
authors.forename: Sidney X
authors.initials: SX
authors.lastname: Liang
authors.forename: Yao-Chang
authors.initials: YC
authors.lastname: Xu