The spindle gets bigger.
Although cortical nonmuscle myosin II has long been implicated in cytokinetic aspects of cell division, there has never been strong evidence that it plays a role in the organization of the mitotic spindle. ([this issue of Cell]) use a number of methods to show that cortical myosin II is in fact important for spindle assembly in higher eukaryotic cells, specifically for the complete separation of centrosomes after nuclear envelope breakdown.
Sawin
Kenneth E
KE
Wellcome Trust Centre for Cell Biology, Edinburgh University, Swann Building, Mayfield Road, Edinburgh EH9 3JR, United Kingdom.
D000199:Actins / Q000378:metabolism; D000577:Amides / Q000494:pharmacology; D018385:Centrosome / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005057:Eukaryotic Cells / Q000378:metabolism; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology; D008954:Models, Biological; D024462:Myosin Type II / Q000378:metabolism*; D009685:Nuclear Envelope / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology; D034622:RNA Interference; D008941:Spindle Apparatus / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D000199:Actins; D000577:Amides; D004791:Enzyme Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D011725:Pyridines; C108830:Y 27632; C472645:blebbistatin; D024462:Myosin Type II