Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo.
Cortical spreading depression (CSD) is accompanied by hyperemia followed by long-lasting hypoperfusion and impaired cerebrovascular reactivity. The authors show that vasodilation to extraluminal acidosis (pH 7.0) and increased concentrations of extraluminal potassium (12, 20, 40 mmol/L) was significantly reduced in isolated rat middle cerebral arteries after CSD in vivo before the artery was isolated, compared with sham-operated controls. Application of 80-mmol/L potassium induced vasoconstriction after CSD. Therefore, the impairment of vascular reactivity after CSD in vivo occurs, at least in part, at the vascular level itself.
Seitz
Iris
I
Experimental Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Dirnagl
Ulrich
U
Lindauer
Ute
U
D000818:Animals; D013181:Cortical Spreading Depression / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D020768:Middle Cerebral Artery / Q000033:anatomy & histology / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D011188:Potassium