Mathematical simulation of the induction of long-term depression in cerebellar Purkinje cells.
The question of the mechanisms underlying the induction of associative and homosynaptic long-term depression in cerebellar Purkinje cells is addressed. Mathematical simulation was used to investigate the possibility that long-term depression, which is associated with a decrease in the efficiency of AMPA receptors, could be induced both by phosphorylation and dephosphorylation of these receptors.
Murzina
G B
GB
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow. gbmurzina@mail.ru
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002531:Cerebellum / Q000502:physiology*; D006801:Humans; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008959:Models, Neurological; D009434:Neural Pathways / Q000502:physiology; D010766:Phosphorylation; D011689:Purkinje Cells / Q000502:physiology*; D018091:Receptors, AMPA / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
D018091:Receptors, AMPA; D002118:Calcium