Antioxidative phenylethanoid and phenolic glycosides from Picrorhiza scrophulariiflora.
One new phenylenthanoid glycoside, scroside D (2), was isolated from the roots of Picrorhiza scrophulariiflora (Scrophulariaceae), together with nine known phenylethanoid and phenolic glycosides: 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (1), 2-(3-hydroxy-4-methoxyphenyl)-ethyl-O-beta-D-glucopyranosyl (1-->3)-beta-D-glucopyranoside (3), scroside B (4), hemiphroside A (5), plantainoside D (6), scroside A (7), androsin (8), piceoside (9), and 6-O-feruloyl-beta-D-glucopyranoside (10). The structures of these compounds were elucidated using spectroscopic methods. The antioxidative activities of these isolated compounds were evaluated based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. Compounds 1, 2, and 6 showed potent antioxidative effects as those of ascorbic acid and the structure-activity relationship is discussed.
Wang
Hao
H
Department of Phytochemistry, China Pharmaceutical University, Nanjing, P.R.China.
Sun
Yang
Y
Ye
Wen-Cai
WC
Xiong
Fei
F
Wu
Jia-Jun
JJ
Yang
Chun-Hua
CH
Zhao
Shou-Xun
SX
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000302:isolation & purification; D032261:Picrorhiza; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots
D000975:Antioxidants; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D010626:Phenylethyl Alcohol