title: Enantioselective allylation of ketone-derived benzoylhydrazones: practical synthesis of tertiary carbinamines.
abstract: A highly practical method for the enantioselective allylation of ketone-derived benzoylhydrazones has been developed. The previously reported strained silacycle reagent 1 reacts with a wide variety of benzoylhydrazones to give the hydrazide products with good to excellent enantioselectivity (84-97% ee). A mechanism in which the acylhydrazone becomes caovalently attached to the silane has been established.
authors.affiliation: Department of Chemistry, Columbia University, New York, New York 10027, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Berger
authors.forename: Keiko
authors.initials: K
authors.lastname: Duff
authors.forename: James L
authors.initials: JL
authors.lastname: Leighton