[Therapeutic angiogenesis by autologous transplantation of bone-marrow cells in a patient with progressive limb ischemia due to arteriosclerosis obliterans: a case report].
A 78-year-old woman with arteriosclerosis obliterans was admitted with complaints of progressive ischemic change and resting pain of the left leg. She had severe ischemic limb in stage IV of the Fontaine classification. Angiography showed total occlusion of the three main arteries with poor collateral flow at the left crus. Autologous transplantation of bone-marrow mononuclear cell to her left leg was performed to achieve therapeutic angiogenesis. One month later, follow-up angiography showed excellent angiogenesis of collateral vessels at the left crus. Her pain was relieved and leg amputation was not necessary. Recently, the TACT study in Japan showed the efficacy of angiogenesis by autologous bone-marrow transplantation for peripheral artery disease. This case illustrates the efficacy of this therapy.
Hasebe
Hideyuki
H
Second Department of Internal Medicine, Yamanashi University School of Medicine, Shimokatoh 1110, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898.
Osada
Mitsuru
M
Kodama
Yasushi
Y
Fujioka
Daisuke
D
Sano
Keita
K
Nakamura
Takamitsu
T
Mitsumori
Tohru
T
Nakamura
Kazuto
K
Kitta
Yoshinobu
Y
Ichiki
Yoshihide
Y
Obata
Jyunei
J
Kawabata
Kenichi
K
Yanagi
Mitsuaki
M
Sano
Sohichi
S
Takano
Hajime
H
Umetani
Ken
K
Kugiyama
Kiyotaka
K
D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications* / Q000628:therapy*; D016026:Bone Marrow Transplantation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000209:etiology* / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D014182:Transplantation, Autologous; D016896:Treatment Outcome