title: Long-term sequelae in children after cerebellar astrocytoma surgery.
abstract: OBJECTIVE
  To study long-term effects on neurologic, neuropsychological, and behavioral functioning in children treated for cerebellar pilocytic astrocytoma (CPA) without additional radio- and chemotherapy.
  
  
  METHODS
  The authors assessed speech, language, nonverbal intelligence, attention, memory, executive skills, and visual (-spatial) functions in a consecutive series of 23 children. Neurologic and neuropsychological follow-up ranged from 1 year to 8 years and 10 months after resection.
  
  
  RESULTS
  Long-term sequelae in the investigated domains were found in all children. Apraxia, motor neglect, and dysarthric features, as well as language, sustained attention, visual-spatial, executive, memory, and behavioral problems, were observed in various combinations and to different degrees. No clear pattern of neurocognitive disturbances could be discerned in this group. In addition, significant relationships were revealed between severity of preoperative hydrocephalus and visual-spatial skills. The high percentage of children who needed special education reflects the severity of the impairments.
  
  
  CONCLUSIONS
  Despite the current opinion of a good quality of life after CPA treatment, careful long-term neurocognitive follow-up is needed in order to inform parents and teachers about the behavioral and cognitive sequelae and to contribute to timely social and educational intervention.
authors.affiliation: Department of Child Neurology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands. f.aarsen@erasmusmc.nl
authors.forename: F K
authors.initials: FK
authors.lastname: Aarsen
authors.forename: H R
authors.initials: HR
authors.lastname: Van Dongen
authors.forename: P F
authors.initials: PF
authors.lastname: Paquier
authors.forename: M
authors.initials: M
authors.lastname: Van Mourik
authors.forename: C E
authors.initials: CE
authors.lastname: Catsman-Berrevoets
mesh_terms: D000293:Adolescent; D000328:Adult; D001072:Apraxias / Q000175:diagnosis / Q000209:etiology; D001254:Astrocytoma / Q000601:surgery*; D002528:Cerebellar Neoplasms / Q000601:surgery*; D002648:Child; D004401:Dysarthria / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis / Q000209:etiology; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology*; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D010468:Perceptual Disorders / Q000175:diagnosis / Q000209:etiology; D013995:Time