title: Synthesis of jaspaquinol and effect on viability of normal and malignant bladder epithelial cell lines.
abstract: The synthesis of jaspaquinol 1, a monocyclic diterpene-benzenoid, is reported. Two synthetic routes to this natural product have been developed. The first, utilises a difunctional terpene derivative containing different leaving groups, facilitating the selective introduction of the cyclohexenyl and benzenoid fragments. The alternative route employs a regiospecific Stille cross-coupling reaction to introduce the cyclohexenyl fragment, which occurs without allylic transposition. Preliminary data shows the cell viability of 1 against normal and malignant human bladder epithelial cell lines.
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Demotie
authors.forename: Ian J S
authors.initials: IJ
authors.lastname: Fairlamb
authors.forename: Feng-Ju
authors.initials: FJ
authors.lastname: Lu
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Shaw
authors.forename: Peter A
authors.initials: PA
authors.lastname: Spencer
authors.forename: Jennifer
authors.initials: J
authors.lastname: Southgate
mesh_terms: D001554:Benzene; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004847:Epithelial Cells / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D013329:Structure-Activity Relationship; D001743:Urinary Bladder / Q000166:cytology; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
chemical_list: D004224:Diterpenes; C494670:jaspaquinol; D001554:Benzene