title: HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing.
abstract: A stem cell registry population from Hong Kong, of Chinese ethnicity, was examined for HLA-A and HLA-B alleles using a two-stage sequence-specific oligonucleotide probe system. Comparison of the HLA-A and HLA-B frequencies with different populations showed a close relationship with a Chinese population from Singapore, although there were several differences in the presence/absence of alleles at the HLA-B locus. Having the data available on these registry donors will influence the search strategy and the ongoing compilation of new donors to the registry. In addition, knowing which alleles do/do not occur in this population will aid in the distinction of ambiguities which result from the use of many of the typing kits available.
authors.affiliation: Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, UK. derek.middleton@bll.n-i.nhs.uk
authors.forename: D
authors.initials: D
authors.lastname: Middleton
authors.forename: B R
authors.initials: BR
authors.lastname: Hawkins
authors.forename: F
authors.initials: F
authors.lastname: Williams
authors.forename: A
authors.initials: A
authors.lastname: Meenagh
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
authors.forename: J
authors.initials: J
authors.lastname: Zamora
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
mesh_terms: D000483:Alleles; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006723:Hong Kong / Q000453:epidemiology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction
chemical_list: D015395:Histocompatibility Antigens Class I