title: Pure red cell aplasia after ABO major-mismatched allogeneic peripheral blood stem cell transplantation successfully treated with plasma exchange and low-dose steroid: two case reports.
abstract: Pure red cell aplasia (PRCA) is a complication of ABO-incompatible allogeneic stem cell transplantation. The mechanism is not well known, although the isoagglutinin titer before transplantation or cyclosporine use is considered to be the cause. Patients with this complication require more blood transfusions than those without it. There is no standard treatment. We report two cases of PRCA after allogeneic peripheral blood stem cell transplantation that were successfully treated with plasma exchange and low-dose steroid.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
authors.forename: Hui-Jen
authors.initials: HJ
authors.lastname: Tsai
authors.forename: Sheng-Fung
authors.initials: SF
authors.lastname: Lin
authors.forename: Ta-Chih
authors.initials: TC
authors.lastname: Liu
authors.forename: Chao-Sung
authors.initials: CS
authors.lastname: Chang
authors.forename: Hui-Hua
authors.initials: HH
authors.lastname: Hsiao
authors.forename: Tyen-Po
authors.initials: TP
authors.lastname: Chen
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications*; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D010951:Plasma Exchange; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy; D014184:Transplantation, Homologous
chemical_list: D000017:ABO Blood-Group System; D000305:Adrenal Cortex Hormones