title: The etiology of severe anemia in a village and a periurban area in Mali.
abstract: Severe anemia is one of the major complications of malaria in Africa. We studied 2 populations, one in a village and the second in a periurban area in Mali, to understand the preventable factors in the disease. The 2 correlates of disease were parasitemia above 100 000 parasitized red blood cells per microliter (0.1 x 10(12)/L) and a low baseline hemoglobin level. All cases of moderate to severe anemia occurred in children under 3.2 years of age. Raising the baseline hemoglobin level and lowering peak parasitemia in infants and young children may reduce the incidence of severe anemia resulting from malarial infection.
authors.affiliation: Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto-Stomatology, University of Bamako, PO Box 1805, Bamako, Mali.
authors.forename: Alassane
authors.initials: A
authors.lastname: Dicko
authors.forename: Amy D
authors.initials: AD
authors.lastname: Klion
authors.forename: Mahamadou A
authors.initials: MA
authors.lastname: Théra
authors.forename: Issaka
authors.initials: I
authors.lastname: Sagara
authors.forename: Daniel
authors.initials: D
authors.lastname: Yalcouyé
authors.forename: Mohamed B
authors.initials: MB
authors.lastname: Niambele
authors.forename: Moussa
authors.initials: M
authors.lastname: Sogoba
authors.forename: Guimogo
authors.initials: G
authors.lastname: Dolo
authors.forename: Adama
authors.initials: A
authors.lastname: Dao
authors.forename: Dapa A
authors.initials: DA
authors.lastname: Diallo
authors.forename: Ogobara K
authors.initials: OK
authors.lastname: Doumbo
authors.forename: Louis H
authors.initials: LH
authors.lastname: Miller
mesh_terms: D000367:Age Factors; D000740:Anemia / Q000453:epidemiology / Q000209:etiology* / Q000469:parasitology / Q000517:prevention & control; D000962:Antimalarials / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D008288:Malaria / Q000150:complications; D008297:Male; D008302:Mali / Q000453:epidemiology; D018512:Parasitemia
chemical_list: D000962:Antimalarials; D006454:Hemoglobins