Projections from primary visual cortex to cytochrome oxidase thin stripes and interstripes of macaque visual area 2.
It has been controversial whether the cytochrome oxidase (CO)-dense blobs in primate primary visual cortex (V1) and CO-dense thin stripes in visual area 2 (V2) are parts of a cortical color-processing stream that is segregated from other functional streams. One of the key pieces of evidence for the segregated color stream is the previous report of specific connections between blobs and thin stripes, which is parallel to the connections between interblobs and interstripes. To study the degree of the segregation between the proposed different streams, in the current study, anatomical tracers were injected into different V2 compartments with the functional guidance of optical imaging. The spatial relationship between each labeled cell and the CO blobs in V1 were analyzed quantitatively. After tracer injections in the color-preferring modules in CO thin stripes, equal amounts of labeled cells were found in the blobs and interblobs. However, the density of the labeled cells was more than twice as high in the blobs as that in the interblobs, and most of the clusters of labeled cells partially overlapped with the blobs. Tracer injections in the interstripes labeled cells predominantly in the interblobs. Our results suggest that both the blobs and interblobs project to the thin stripes and call into question the proposition that different CO compartments in V1 and V2 are connected in parallel to form highly segregated functional streams.
Xiao
Youping
Y
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX 77030, USA.
Felleman
Daniel J
DJ
D000818:Animals; D003118:Color Perception / Q000502:physiology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D001330:Electronic Data Processing; D008252:Macaca fascicularis; D014793:Visual Cortex / Q000201:enzymology* / Q000378:metabolism
D003576:Electron Transport Complex IV