title: Bielschowskysin, a gorgonian-derived biologically active diterpene with an unprecedented carbon skeleton.
abstract: Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.
authors.affiliation: Department of Chemistry, University of Puerto Rico, PO Box 23346, U.P.R. Station, San Juan, Puerto Rico 00931-3346.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Marrero
authors.forename: Abimael D
authors.initials: AD
authors.lastname: Rodríguez
authors.forename: Peter
authors.initials: P
authors.lastname: Baran
authors.forename: Raphael G
authors.initials: RG
authors.lastname: Raptis
authors.forename: Juan A
authors.initials: JA
authors.lastname: Sánchez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortega-Barria
authors.forename: Todd L
authors.initials: TL
authors.lastname: Capson
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D004224:Diterpenes; C494537:bielschowskysin