Genes influencing Parkinson disease onset: replication of PARK3 and identification of novel loci.
A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.
Pankratz
N
N
Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN, USA.
Uniacke
S K
SK
Halter
C A
CA
Rudolph
A
A
Shults
C W
CW
Conneally
P M
PM
Foroud
T
T
Nichols
W C
WC
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D005190:Family; D005260:Female; D005838:Genotype; D005858:Germany / Q000208:ethnology; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D014481:United States / Q000208:ethnology; D044465:White People / Q000235:genetics
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein