title: Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctions.
abstract: Thyroid dysfunction is associated with metabolic changes that affect mass and adipocyte function, as well as lipid and carbohydrate metabolism. Adipose tissue performs complex metabolic and endocrine functions. Leptin and adiponectin are two of the most important adipocytokines, both involved in the regulation of intermediate metabolism. The aim of this study was to evaluate the relationships between thyroid status and circulating levels of the two adipose tissue hormones. We studied 15 patients with hyperthyroidism, 15 patients with hypothyroidism and 15 euthyroid subjects, all matched by sex, age and body mass index (BMI). Serum concentrations of free thyroxine, free tri-iodothyronine, thyrotropin, leptin and adiponectin and anthropometric parameters (weight, height, BMI) were assessed. No significant difference was found among the 3 groups, as assessed by Student's t-test, both for adiponectin and leptin. We conclude that metabolic changes associated with thyroid dysfunction are not related to variations in serum levels of adiponectin or leptin.
authors.affiliation: Department of Endocrinology, University of Pisa, Pisa, Italy. fsantini@endoc.med.unipi.it
authors.forename: F
authors.initials: F
authors.lastname: Santini
authors.forename: A
authors.initials: A
authors.lastname: Marsili
authors.forename: C
authors.initials: C
authors.lastname: Mammoli
authors.forename: R
authors.initials: R
authors.lastname: Valeriano
authors.forename: G
authors.initials: G
authors.lastname: Scartabelli
authors.forename: C
authors.initials: C
authors.lastname: Pelosini
authors.forename: M
authors.initials: M
authors.lastname: Giannetti
authors.forename: R
authors.initials: R
authors.lastname: Centoni
authors.forename: P
authors.initials: P
authors.lastname: Vitti
authors.forename: A
authors.initials: A
authors.lastname: Pinchera
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000886:Anthropometry; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism; D007037:Hypothyroidism / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine