Decrease of pigment epithelium-derived factor in aqueous humor with increasing age.
OBJECTIVE
To determine whether the level of pigment epithelium-derived factor (PEDF) in the aqueous humor is altered with age.


METHODS
Observational case series.


METHODS
The PEDF concentration in the aqueous humor was measured by enzyme-linked immunosorbent assay in 152 eyes of 121 patients who underwent cataract surgery.


RESULTS
The mean aqueous level of PEDF was 0.86 +/- 0.04 microg/ml (mean +/- standard error, 70.7 +/- 1.0 years). The PEDF levels decreased with increasing age, and the decrease was significantly correlated with age (Pearson product moment correlation coefficient, r = - 0.22, P =.006). The mean PEDF level in the men (0.76 +/- 0.06 microg/ml, 53 eyes, 71.5 +/- 2.0 years) was significantly lower than that in women (0.91 +/- 0.04 microg/ml, 99 eyes, 70.2 +/- 1.1 year, P =.03).


CONCLUSIONS
The negative correlation of PEDF level and age should be considered in age-related eye diseases, especially those associated with angiogenesis.
Ogata
Nahoko
N
Department of Ophthalmology, Kansai Medical University, Fumizono-cho 10-15, Moriguchi, Osaka 570-8507, Japan. ogata@takii.kmu.ac.jp
Matsuoka
Masato
M
Imaizumi
Masahito
M
Arichi
Miwa
M
Matsumura
Miyo
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors; D011506:Proteins / Q000378:metabolism*; D015843:Serpins / Q000378:metabolism*; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D011506:Proteins; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor