title: Unprecedented copper-catalyzed asymmetric conjugate addition of organometallic reagents to alpha,beta-unsaturated lactams.
abstract: For the first time, an excellent enantioselectivity has been obtained in the conjugate addition of hard organometallic reagents to alpha,beta-unsaturated lactams bearing appropriate protecting-activating groups on the nitrogen.
authors.affiliation: Dipartimento di Chimica Bioorganica e Biofarmacia, Universita di Pisa, Via Bonanno 33, 56126 Pisa, Italy. pineschi@farm.unipi.it
authors.forename: Mauro
authors.initials: M
authors.lastname: Pineschi
authors.forename: Federica
authors.initials: F
authors.lastname: Del Moro
authors.forename: Francesca
authors.initials: F
authors.lastname: Gini
authors.forename: Adriaan J
authors.initials: AJ
authors.lastname: Minnaard
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D007769:Lactams / Q000737:chemistry / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007769:Lactams; D009942:Organometallic Compounds; D003300:Copper