Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes.
A new method for the preparation of 2-substituted oxazolines by rhodium-catalyzed coupling of alkenes with 4,4-dimethyl-2-oxazoline is reported. The oxazoline products are obtained in good yield with excellent selectivity for the linear product. A variety of alkene substitution patterns and functional groups are tolerated. This procedure represents an attractive alternative to hydroesterification because it does not involve the manipulation of CO gas.
Wiedemann
Sean H
SH
Department of Chemistry, University of California Berkeley, California 94720, USA.
Bergman
Robert G
RG
Ellman
Jonathan A
JA
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
C494539:4,4-dimethyl-2-oxazoline; D000475:Alkenes; D010080:Oxazoles; D012238:Rhodium