title: Lipoxygenase inhibiting and antioxidant oligostilbene and monoterpene galactoside from Paeonia emodi.
abstract: Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition, 4-hydroxybenzoic acid 3, gallic acid 4 and methyl gallate 5 have also been reported for the first time from this species. Compounds 1 and 2 have displayed potent inhibitory potential against enzyme lipoxygenase in a concentration-dependent fashion with the IC(50) values 0.77 and 99.5 microM, along with ABTS(.+) radical quenching activity with IC(50) values of 147.5 and 498.2 microM, respectively.
authors.affiliation: International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Naheed
authors.initials: N
authors.lastname: Riaz
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Aziz-ur
authors.initials: AU
authors.lastname: Rehman
authors.forename: Zaheer
authors.initials: Z
authors.lastname: Ahmed
authors.forename: Pir
authors.initials: P
authors.lastname: Muhammad
authors.forename: Sarfraz Ahmad
authors.initials: SA
authors.lastname: Nawaz
authors.forename: Juveria
authors.initials: J
authors.lastname: Siddiqui
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D005697:Galactosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D029596:Paeonia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D005697:Galactosides; D016859:Lipoxygenase Inhibitors; D039821:Monoterpenes; D010936:Plant Extracts; D013267:Stilbenes; C006680:baicalein