title: Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens.
abstract: Four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC(50) values of 2.4 x 10(-6), 2.6 x 10(-6), and 2.1 x 10(-6) M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.
authors.affiliation: College of Pharmacy, Wonkwang University, Iksan, Korea.
authors.forename: Youn Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Hye-Sook
authors.initials: HS
authors.lastname: Kim
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Wataya
authors.forename: Dong Hwan
authors.initials: DH
authors.lastname: Sohn
authors.forename: Tai Hyun
authors.initials: TH
authors.lastname: Kang
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Yong Man
authors.initials: YM
authors.lastname: Kim
authors.forename: Geon-Mok
authors.initials: GM
authors.lastname: Lee
authors.forename: Jong-Duk
authors.initials: JD
authors.lastname: Chang
authors.forename: Hyun
authors.initials: H
authors.lastname: Park
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects / Q000502:physiology; D029909:Sophora
chemical_list: D000962:Antimalarials; D044950:Flavanones