title: Use of fluorine in the medicinal chemistry and chemical biology of bioactive compounds--a case study on fluorinated taxane anticancer agents.
authors.affiliation: Institute of Chemical Biology and Drug Discovery and Department of Chemistry, State University of New York, Stony Brook, NY 11794-3400, USA. iojima@notes.cc.sunysb.edu
authors.forename: Iwao
authors.initials: I
authors.lastname: Ojima
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000077143:Docetaxel; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D017239:Paclitaxel / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D005461:Fluorine; D017239:Paclitaxel