Composition of LDL particle discriminates between hypercholesterolaemic persons with and without symptoms of coronary heart disease.
BACKGROUND
It is well known that high total and LDL cholesterol concentrations are not prerequisites for ischemic heart disease. This study aimed to differentiate between patients with coronary heart symptoms and healthy subjects with high cholesterol concentrations, using other potential risk factors such as oxidation state, body iron status and the oxidative state of the LDL particle.


METHODS
Healthy persons were divided in low cholesterol (<6 mmol/L) (LC) and high cholesterol (> or =6 mmol/L) (HC) groups. An additional group consisted of patients with symptoms of coronary heart disease (P). The lipid profile, body iron status, plasma antioxidants and LDL oxidation status were measured.


RESULTS
No significant differences could be observed between the LC and HC groups or between the lipid profiles, plasma antioxidants and parameters of body iron status of the HC and patient groups. Some parameters measured on isolated LDL differed between the HC and patient groups, such as LDL oxidative potential (134.47 vs 93.70 min) and LDL alpha-tocopherol (21.83 vs 11.73 micro mol/mmol cholesterol).


CONCLUSIONS
The oxidative state of the LDL particle discriminated between patients with symptoms of coronary heart disease and hypercholesterolaemic persons without symptoms of coronary heart disease.
Van Jaarsveld
Henretha
H
Department of Chemical Pathology, University of the Free State, PO Box 339, Bloemfontein 9300, Republic of South Africa. gncphvj.MD@mail.uovs.ac.za
Pool
Gertruida F
GF
Bester
Catharina J
CJ
D000975:Antioxidants / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000737:chemistry*; D003327:Coronary Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D007501:Iron / Q000097:blood / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010084:Oxidation-Reduction; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol; D007501:Iron