The hemolytic activity of epoxydammarane triterpenoids.
The hemolytic activity of the epoxydammarane triterpenoids isolated from the Far-East species of the genus Betula and their semi-synthetic derivatives was investigated. Comparative studies of epoxydammarane triterpenoid activities at pH 5.5 and 5.0 and at 37 and 42 degrees C showed that 3-oxo, 3,11-dioxo, 3- and 11-acetoxy, as well as 3,11-diacetoxy derivatives had hemolytic potencies lower than the corresponding polyols; triterpenoids with a 3alpha-OH group were stronger than their analogues with a 3beta-OH group; epoxydammaranetriols were somewhat more potent than epoxydammaranediols. Triterpenoids esterified with malonic acid at C-3 possessed the strongest hemolytic activity among the tested compounds.
Prokof'eva
N G
NG
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russian Federation.
Anisimov
M M
MM
Shentsova
E B
EB
Pokhilo
N D
ND
D029662:Betula; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000097669:Dammaranes
D010936:Plant Extracts; D014315:Triterpenes; D000097669:Dammaranes