Neurofibromatosis in children with Rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma study IV.
We identified all children enrolled in the Intergroup Rhabdomyosarcoma Study Group-IV with neurofibromatosis type I (NF1) and rhabdomyosarcoma. Among 1025 eligible patients, 5 (0.5 %) had NF1. Three children had relapses, two of whom died of progressive disease. Patients with NF1 and rhabdomyosarcoma should be treated with intensive contemporary therapy protocols.
Sung
Lillian
L
Division of Hematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.
Anderson
James R
JR
Arndt
Carola
C
Raney
R Beverly
RB
Meyer
William H
WH
Pappo
Alberto S
AS
D000293:Adolescent; D002170:Canada / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000473:pathology; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000453:epidemiology / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000473:pathology