title: Field evaluation of moxidectin/praziquantel oral gel in horses.
abstract: The safety and efficacy of 2% moxidectin/12.5% praziquantel oral gel administered at a rate of 0.4 mg moxidectin and 2.5 mg praziquantel/kg was studied in client-owned horses under field use conditions. Four hundred horses (300 treated with moxidectin/praziquantel oral gel and 100 treated with vehicle) were enrolled, feces were collected, and eggs were counted. Investigators as well as horse owners were masked to treatment assignment. No adverse reactions to treatment were observed in any horses. Moxidectin/praziquantel gel reduced Anoplocephala spp by more than 99% and provided a significant (P <.05) reduction (> 98%) in the strongyle egg count of treated horses.
authors.affiliation: Fort Dodge Animal Health, PO Box 5366, Princeton, NJ 08543, USA.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Grubbs
authors.forename: Debbie
authors.initials: D
authors.lastname: Amodie
authors.forename: Dino
authors.initials: D
authors.lastname: Rulli
authors.forename: Meghan
authors.initials: M
authors.lastname: Wulster-Radcliffe
authors.forename: Craig
authors.initials: C
authors.lastname: Reinemeyer
authors.forename: Tom
authors.initials: T
authors.lastname: Yazwinski
authors.forename: Chris
authors.initials: C
authors.lastname: Tucker
authors.forename: Doug
authors.initials: D
authors.lastname: Hutchens
authors.forename: Larry
authors.initials: L
authors.lastname: Smith
authors.forename: Deborah
authors.initials: D
authors.lastname: Patterson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005782:Gels; D006736:Horses; D018942:Macrolides / Q000008:administration & dosage*; D011223:Praziquantel / Q000008:administration & dosage*; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D013323:Strongylus / Q000302:isolation & purification; D016896:Treatment Outcome; D014481:United States
chemical_list: D000871:Anthelmintics; D004338:Drug Combinations; D005782:Gels; D018942:Macrolides; D011223:Praziquantel; C027837:moxidectin