Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae).
An aqueous extract of the aerial part of Peperomia pellucida (L.) HBK (Piperaceae) was tested for anti-inflammatory (paw edema induced by carrageenin and arachidonic acid) and analgesic activity (abdominal writhes and hot plate) in rats and mice, respectively. Oral administration of 200 and 400 mg/kg of the aqueous extract exhibited an anti-inflammatory activity in the carrageenin test, which was based on interference with prostaglandin synthesis, as confirmed by the arachidonic acid test. In the abdominal writhing test induced by acetic acid, 400 mg/kg of the plant extract had the highest analgesic activity, whereas in the hot-plate test the best dose was 100 mg/kg. The LD(50) showed that Peperomia pellucida (5000 mg/kg) presented low toxicity.
de Fátima Arrigoni-Blank
Maria
M
Laboratório de Farmacologia, Departamento de Fisiologia/CCBS, Universidade Federal de Sergipe, Campus Universitário, São Cristóvão, SE CEP 49100-000, Brazil.
Dmitrieva
Elena G
EG
Franzotti
Elaine Maria
EM
Antoniolli
Angelo Roberto
AR
Andrade
Márcio Roberto
MR
Marchioro
Murilo
M
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016718:Arachidonic Acid; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006358:Hot Temperature; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D036941:Peperomia; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D016718:Arachidonic Acid; D002351:Carrageenan; D019342:Acetic Acid