Plasminogen activator inhibitor type-1: its structure, biological activity and role in tumorigenesis (Review).
Plasminogen activator inhibitor type-1 (PAI-1), is a unique member of serpin superfamily, the primary regulator of plasminogen activation and therefore essential factor regulating physiological thrombotic/fibrinolytic balance in vivo. Via interactions with integrins and extracellular matrix components it orchestrates also cell adhesion and migration. Therefore, PAI-1 is considered one of the key regulators of tumor invasion and metastasis, as well as cancer-related angiogenesis. This review summarizes recent findings on the structure and functional activity of the plasminogen activator inhibitor type-1, and current opinions on its role in tumorigenesis.
Chorostowska-Wynimko
Joanna
J
Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
Skrzypczak-Jankun
Ewa
E
Jankun
Jerzy
J
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D015843:Serpins / Q000378:metabolism*
D016023:Integrins; D017395:Plasminogen Activator Inhibitor 1; D015843:Serpins; D010958:Plasminogen