Delayed neurotrophin treatment supports auditory neuron survival in deaf guinea pigs.
As key factors in the development and maintenance of the auditory system, neurotrophins can prevent auditory neuron degeneration when applied within three to five days of deafening. We tested each of the neurotrophins BDNF, NT-3, NT-4/5 and NGF for their ability to support auditory neuron survival following a two-week period of deafness in guinea pigs, when approximately 15% auditory neuron degeneration has already occurred. Although delayed, the treatment with each neurotrophin prevented further degeneration with similar efficacy.
Gillespie
Lisa N
LN
Department of Otolaryngology, The University of Melbourne, 2nd Floor, Eye and Ear Hospital, East Melbourne, Victoria, Australia 3002. lgillespie@bionicear.org
Clark
Graeme M
GM
Marzella
Phillip L
PL
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003051:Cochlea / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D003056:Cochlear Nerve / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D003638:Deafness / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009414:Nerve Growth Factors / Q000008:administration & dosage*; D013997:Time Factors
D009414:Nerve Growth Factors