Prospective association between hypotension and idiopathic chronic fatigue.
OBJECTIVE
To determine whether there is an association between hypotension and incident cases of idiopathic chronic fatigue.


METHODS
A prospective study.


METHODS
Johns Hopkins Precursors Study.


METHODS
Medical students (n = 876) in graduating classes from 1948 to 1964.


METHODS
'Easy fatigability' reported by participants at 5- or 10-year follow-up after graduation.


RESULTS
The unadjusted risk in women was 5.0 (95% exact confidence interval = 1.4 to 17.4) and in men was 1.7 (95% exact confidence interval = 0.8, to 3.5).


CONCLUSIONS
These preliminary findings suggest that hypotension may be a risk factor for the development of idiopathic chronic fatigue in women.
Lucas
Katherine E
KE
Bloomberg School of Public Health and School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205-2233, USA.
Rowe
Peter C
PC
Coresh
Josef
J
Klag
Michael J
MJ
Meoni
Lucy A
LA
Ford
Daniel E
DE
D000328:Adult; D016001:Confidence Intervals; D005221:Fatigue / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007022:Hypotension / Q000453:epidemiology / Q000503:physiopathology*; D015994:Incidence; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013337:Students, Medical / Q000706:statistics & numerical data; D011795:Surveys and Questionnaires; D013997:Time Factors