Intrauterine growth retardation: study of placental apoptosis.
We studied the rate of apoptosis in the placental tissue of pregnancies complicated with intrauterine growth retardation (IUGR) and compared it with the results obtained in normal placentas. Our results clearly demonstrate a strongly increased rate of apoptosis in placentas of children born with IUGR, suggesting severe placental dysfunction. The significance of these findings needs further study.
Barrio
E
E
Department of Molecular Genetics, University Children's Hospital Miguel Servet, Zaragoza, Spain. barrioeva@hotmail.com
Calvo
M T
MT
Romo
A
A
Alvarez
R
R
Gutiérrez
J I
JI
Naval
J
J
Ferrández Longás
A
A
D017209:Apoptosis; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology*; D018922:HL-60 Cells; D006801:Humans; D020287:In Situ Nick-End Labeling / Q000379:methods; D011247:Pregnancy; D014327:Trophoblasts / Q000473:pathology* / Q000648:ultrastructure*