Steroidal saponins from Dioscorea panthaica and their cytotoxic activity.
A new steroidal saponin, dioscoreside E (1), and a known compound, protodioscin (2), were isolated from an ethanol extract of the rhizomes of Dioscorea panthaica. The structure of 1 was established as 3-O-[bis-alpha-L-rhamnopyranosyl-(1 --> 2 and 1 --> 4)-beta-D-glucopyranosyl]-26-O-beta-D-glucopyranosyl-20(R)-methoxy-25(R)-furosta-5,22(23)-diene-3beta,26-diol, on the basis of spectral and chemical evidence. Compounds 1 and 2 showed cytotoxic activity against a panel of tumor cell lines.
Dong
M
M
Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Ohio, USA.
Feng
X Z
XZ
Wang
B X
BX
Ikejima
T
T
Wu
L J
LJ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D027742:Dioscorea / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013256:Steroids; C485325:dioscoreside E