Tumor-level serum testosterone associated with human immunodeficiency virus lipodystrophy syndrome.
BACKGROUND
Human immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome.


METHODS
A 30-year-old HIV-positive multipara with lipodystrophy syndrome had an elevated level of serum total testosterone (244 ng/dL) in the tumor range.


CONCLUSIONS
In HIV lipodystrophy syndrome, marked elevations of total serum testosterone in the range reserved for androgen-producing tumors may occur. The elevated testosterone levels are derived from the ovary and are responsive to gonadotropin suppression.
Dahan
Michael H
MH
Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri 63108-2259, USA. dahanhaim@hotmail.com
Lyle
Larry N
LN
Wolfsen
Ada
A
Chang
R Jeffrey
RJ
D000328:Adult; D005260:Female; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007273:Injections, Intramuscular; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use; D010053:Ovary / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood*
D013739:Testosterone; D016729:Leuprolide