Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides.
A series of novel 6-O-arylpropargyl-9-oxime-ketolides was synthesized and evaluated against various pathogens. These new compounds show promising in vitro antibacterial potency and in vivo efficacy against macrolide resistant strains.
Beebe
Xenia
X
Infectious Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA. xenia.b.searle@abbott.com
Yang
Fan
F
Bui
Mai H
MH
Mitten
Michael J
MJ
Ma
Zhenkun
Z
Nilius
Angela M
AM
Djuric
Stevan W
SW
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D006193:Haemophilus influenzae / Q000187:drug effects; D048628:Ketolides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D018942:Macrolides; D051381:Rats; D012141:Respiratory Tract Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides