title: Effects of cardiopulmonary bypass on the expression of adhesive molecules in children undergoing cardiac surgery due to congenital heart disorders.
abstract: BACKGROUND
  Infants and small children who undergo cardiac surgery due to congenital heart disorders, are at risk of developing inflammatory complications and multi-organ failure.
  
  
  OBJECTIVE
  To assess the changes in the expression of adhesive molecules on neutrophils and in peripheral blood plasma in children undergoing cardiac surgery with or without the use of cardiopulmonary bypass (CPB).
  
  
  METHODS
  In 18 children who underwent surgery with the use of CPB and in 7 children who underwent surgery without CPB, the expression of CD11b, CD11c and CD62L molecules on neutrophils and soluble adhesive molecules - L-selectin and ICAM-1, was assessed before, during and after cardiac surgery.
  
  
  RESULTS
  A significant increase in the expression of CD11b on neutrophils at the time of the initiation of CPB was observed. The most pronounced decrease in the expression of CD11c was detected at the end of surgical procedure. There was also a negative correlation between L-selectin concentration measured at the end of CPB and CPB duration as well as between ICAM-1 concentration and duration of hypothermia.
  
  
  CONCLUSIONS
  Cardiac surgery influences the expression of adhesive molecules on neutrophils and in blood plasma. These changes are more pronounced in children who undergo CPB, and depend on CPB duration as well as the use of hypothermia.
authors.affiliation: Department of Paediatrics and Immunology of Young Age, Institute of the Polish Mother Health Center, Łódź, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Paśnik
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Baj
authors.forename: Jadwiga A
authors.initials: JA
authors.lastname: Moll
authors.forename: Jacek
authors.initials: J
authors.lastname: Moll
authors.forename: Maciej
authors.initials: M
authors.lastname: Moll
authors.forename: Lech
authors.initials: L
authors.lastname: Pokoca
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sysa
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zeman
mesh_terms: D039481:CD11b Antigen / Q000097:blood; D039521:CD11c Antigen / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D019041:L-Selectin / Q000097:blood; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D011183:Postoperative Complications / Q000209:etiology
chemical_list: D039481:CD11b Antigen; D039521:CD11c Antigen; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin