title: Interleukin-6 family of cytokines as biochemical markers of osseous changes in the temporomandibular joint disorders.
abstract: The aim of this study was to find out whether there was a correlationship between the concentrations of interleukin-6 (IL-6), IL-11, and IL-17 in synovial fluid and osseous changes in the condyle. The synovial fluid was obtained from 61 patients with temporomandibular joint disorders (TMD) and seven healthy volunteers (controls). The concentrations of IL-6, IL-11, and IL-17 were measured by enzyme-linked immunosorbent assay. IL-6 was detected in 43 of 59 (73%), IL-11 in 23 of 52 (44%) and IL-17 in 14 of 51 (27%) samples of synovial fluid. The concentrations of IL-6 and IL-11 in the joints with osseous changes in the condyle were significantly higher than in the joints without osseous changes (P < 0.05) and also higher than in the joints of the control group (P < 0.05). In addition, there was a correlation of concentrations between IL-6 and IL-11 (P < 0.05). These results suggest that IL-6 and IL-11 may participate in the pathogenesis of TMD and induce osseous changes in the condyle.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-pref. 920-0293, Japan. k-k@kanezawa-med.ac.jp
authors.forename: Keiseki
authors.initials: K
authors.lastname: Kaneyama
authors.forename: Natsuki
authors.initials: N
authors.lastname: Segami
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nishimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshimura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001862:Bone Resorption / Q000276:immunology / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007223:Infant; D017370:Interleukin-11 / Q000378:metabolism; D020381:Interleukin-17 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007378:Interleukins / Q000096:biosynthesis*; D004204:Joint Dislocations / Q000276:immunology / Q000378:metabolism; D008297:Male; D008335:Mandibular Condyle / Q000473:pathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000276:immunology / Q000378:metabolism; D018709:Statistics, Nonparametric; D013582:Synovial Fluid / Q000276:immunology / Q000378:metabolism; D013705:Temporomandibular Joint Disorders / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D017370:Interleukin-11; D020381:Interleukin-17; D015850:Interleukin-6; D007378:Interleukins