Prematurity at birth and adolescent depressive disorder.
Association between prematurity/low birthweight and adolescent depressive disorder studied using a case-control design within a prospective cohort study of 2032 adolescents. Odds for depressive disorder were 11-fold (95% CI 2-62) higher for the premature/low-birthweight participants after regression adjustment for major confounding factors. For premature/low-birthweight females, cumulative rates of depressive disorder over 30 months were 15.2% (95% CI 11.1-20.5) v. 1.8% (95% CI 1.6-2.1) in those with normal deliveries. Physiological adaptations in utero before full term may be implicated causally in some cases of depression in adolescence.
Patton
George C
GC
Murdoch Children's Research Institute, Centre for Adolescent Health, Parkville, Victoria, Australia. george.patton@rch.org.au
Coffey
Carolyn
C
Carlin
John B
JB
Olsson
Craig A
CA
Morley
Ruth
R
D000293:Adolescent; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000523:psychology; D007231:Infant, Newborn; D007234:Infant, Premature / Q000523:psychology*; D008297:Male; D016487:Parenting; D012307:Risk Factors; D014739:Victoria / Q000453:epidemiology