title: [Rheological and biopharmaceutical investigation of polymer drug delivery systems].
abstract: Drug release of watersoluble active agent (ephedrine hydrochloride) and water-insoluble ones (griseofulvine, salicylic acid, sulfadimidine) from hydrogels containing different polymers was investigated. The rheological behaviour of polymer matrices was characterized by flow curves and viscosity curves. These hydrogels were not thixotropic systems, unlike more authors' statement. The values of rheological constants increase exponentially with concentration of polymers. The liberation of active agents can be characterized by a multiplicative function. The constant of viscosity vs. concentration function was determined and it was called as characteristic of structure formation. A linear relationship between constant of structure formation and drug liberation was demonstrated.
authors.affiliation: Szegedi Tudományegyetem, Gyógyszertechnológiai Intézet, Szeged.
authors.forename: István
authors.initials: I
authors.lastname: Erös
authors.forename: Anita
authors.initials: A
authors.lastname: Blum
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Csányi
authors.forename: Ildikó
authors.initials: I
authors.lastname: Csóka
authors.forename: Ferenc
authors.initials: F
authors.lastname: Illyés
authors.forename: Tünde
authors.initials: T
authors.lastname: Takács-Wormsdorff
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods*; D007700:Kinetics; D011108:Polymers; D012212:Rheology
chemical_list: D011108:Polymers