title: Elasticity of small artery in patient with spontaneous rupture of hepatocellular carcinoma.
abstract: Objective: Spontaneous rupture of hepatocellular carcinoma (HCC) is common in Asia and Africa with unclear mechanism. In our previous study, we found that the vascular injury was related to the HCC rupture. In this study, the structure of elastin around the small artery was deeply investigated to confirm our previous study. Methods: Immunohistochemical technique and transmission electron microscopy were used to study 23 specimens from ruptured HCC and 30 cases with nonruptured HCC. Results: The layer of elastin around the vascular wall was significant thicker in patients with ruptured HCC than that in nonruptured HCC. The proliferation of elastin, abnormal distribution of neutrophil elastase and degradation of collagen fibril were predominantly present in the specimens from ruptured HCC. The phenomenon that the infiltrated neutrophils from bloodstream into the vascular wall, which caused the vascular injury, can be found in specimens from ruptured HCC. The vascular injury mainly occurred in small artery. Since the damaged vessels could become stiff and weak, which would be more prone to splitting and result in hemorrhage in patients with ruptured HCC, we postulated that the vascular injury, especially the inelastic small artery, may relate the ruptured HCC. Conclusion: The vascular injury in small artery might relate to ruptured HCC.
authors.affiliation: Department of Surgery, Affiliated Hospital of Anhui Medical University, Anhui, Hefei 230022, PR China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Zhu
authors.forename: Xiang-Ling
authors.initials: XL
authors.lastname: Meng
authors.forename: Sheung-Tat
authors.initials: ST
authors.lastname: Fan