title: Senile chorea treated by deep brain stimulation: a clinical, neurophysiological and functional imaging study.
abstract: We report on a patient with senile chorea, treated with deep brain stimulation of the left globus pallidus internus and subsequently the left ventralis oralis posterior nucleus of the thalamus. Deep brain field potential recordings and functional imaging using single photon emission tomography enabled us to suggest pathophysiological mechanisms for the symptoms.
authors.affiliation: The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Yianni
authors.forename: Dipankar
authors.initials: D
authors.lastname: Nandi
authors.forename: Kevin
authors.initials: K
authors.lastname: Bradley
authors.forename: Nigel
authors.initials: N
authors.lastname: Soper
authors.forename: Ralph
authors.initials: R
authors.lastname: Gregory
authors.forename: Carole
authors.initials: C
authors.lastname: Joint
authors.forename: John
authors.initials: J
authors.lastname: Stein
authors.forename: Richard
authors.initials: R
authors.lastname: Scott
authors.forename: Tipu
authors.initials: T
authors.lastname: Aziz
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D002819:Chorea / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D004576:Electromyography / Q000295:instrumentation; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018482:Muscle, Skeletal / Q000503:physiopathology; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon