Effects of some natural flavonoids on retinal function recovery after ischemic insult in the rat.
OBJECTIVE
There are six natural flavonoids studied recently and their effects on ocular blood flow measured with colored microsphere technique. It was found that three out of six compounds showed strong positive effects in increasing the ocular blood flow. In this study, we tried to find out whether these results can be translated on their effects to improve retinal function recovery after ischemic insult.


METHODS
Electroretinography was used to measure the b-wave recovery as an indication of retinal function recovery.


RESULTS
Naringenin, hesperetin, and rutin were found to produce marked positive effects on b-wave recovery, whereas naringin, hesperidin, and quercetin showed poor recovery of b-wave after ischemic insult of the retina.


CONCLUSIONS
It was found that the compounds that showed strong increase of ocular blood flow also showed marked increase of retinal function recovery, whereas those that showed poor increase of ocular blood flow also showed poor effects on the retinal function recovery.
Chiou
George C Y
GC
Institute of Ocular Pharmacology and Department of Medical Pharmacology and Toxicology, Texas A and M University System Health Science Center, College of Medicine, College Station, TX 77843, USA. gchiou@tamu.edu
Xu
Xin-Rong
XR
D000818:Animals; D019842:Ciliary Arteries / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D020318:Rats, Long-Evans; D012039:Regional Blood Flow / Q000187:drug effects; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000503:physiopathology; D012160:Retina / Q000187:drug effects*; D012161:Retinal Artery / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D005419:Flavonoids