McCune-Albright syndrome associated with pituitary microadenoma: patient report.
McCune-Albright syndrome (MAS) is a rare disorder characterized by the classic triad of precocious puberty, polyostotic fibrous dysplasia and café-au-lait spots. Additional endocrine abnormalities may also be present, including hyperthyroidism, growth hormone excess and hyperprolactinemia. The most commonly encountered endocrine dysfunction is gonadal hyperfunction. Gonadotropin-independent precocious puberty is typically the initial manifestation of MAS in girls. Ovarian cysts may be detected on pelvic ultrasound. Our patient was also found to have pituitary microadenoma, evidenced by dynamic magnetic resonance imaging.
Chen
Chun-Jung
CJ
Department of Pediatrics, Tri-service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Liu
Jah-Yao
JY
Cheng
Shin-Nan
SN
Chang
Fung-Wei
FW
Yuh
Yeong-Seng
YS
D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis; D044466:Asian People; D019080:Cafe-au-Lait Spots / Q000150:complications* / Q000175:diagnosis; D004700:Endocrine System Diseases; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D005951:Glucose Tolerance Test; D006066:Gonads / Q000378:metabolism / Q000503:physiopathology; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications; D006980:Hyperthyroidism / Q000150:complications / Q000175:diagnosis; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D010048:Ovarian Cysts / Q000150:complications / Q000175:diagnosis / Q000000981:diagnostic imaging; D010388:Pelvis / Q000000981:diagnostic imaging; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D011629:Puberty, Precocious / Q000150:complications* / Q000175:diagnosis; D011859:Radiography; D013629:Tamoxifen / Q000627:therapeutic use; D013964:Thyroid Neoplasms / Q000150:complications* / Q000175:diagnosis; D014463:Ultrasonography; D019522:Vaginal Discharge / Q000209:etiology
D013629:Tamoxifen; D019382:Human Growth Hormone