B-cell antigen receptor signaling requirements for targeting antigen to the MHC class II presentation pathway.
The ability of B lymphocytes to capture, process and present antigens to T cells is requisite for normal humoral immune responses and contributes to the pathogenesis of both B- and T-cell-mediated autoimmune diseases. B lymphocytes preferentially capture polyvalent antigens, which are capable of eliciting a coordinated series of cellular responses that ensure that even low-affinity antigens are productively captured. Polyvalency not only accelerates transit through the endocytic pathway but also induces a reorganization of the antigen-processing compartment, activates degradative pathways and determines how antigenic peptides are presented to T cells. Similar changes are observed in maturing dendritic cells, indicating that some cellular responses to foreign antigens are conserved.
Clark
Marcus R
MR
Department of Medicine, Section of Rheumatology, University of Chicago, Chicago IL 60637, USA. mclark@medicine.bsd.uchicago.edu
Massenburg
Donald
D
Siemasko
Karyn
K
Hou
Ping
P
Zhang
Miao
M
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D000941:Antigens; D000949:Histocompatibility Antigens Class II; D011947:Receptors, Antigen, B-Cell