Hypoadiponectinemia is an independent risk factor for hypertension.
Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease. Genetic investigation has revealed that 2 polymorphisms (I164T and G276T) are related to adiponectin concentration and diabetes. To examine whether adiponectin affects hypertension genetically or biologically, we performed a case-control study. A total of 446 diagnosed cases of hypertension (HT) in men and 312 normotensive (NT) men were enrolled in this study. Plasma adiponectin concentration was measured using an enzyme-linked immunosorbent assay system. Single nucleotide polymorphisms were determined by TaqMan polymerase chain reaction method. After adjustment for confounding factors, adiponectin concentration was significantly lower in HT (HT: 5.2+/-0.2 microg/mL; NT: 6.1+/-0.2 microg/mL; P<0.001). Furthermore, multiple regression analysis indicated that hypoadiponectinemia was an independent risk factor for hypertension (P<0.001). Blood pressure was inversely associated with adiponectin concentration in normotensives regardless of insulin resistance. In subjects carrying the TC genotype of the I164T polymorphism, adiponectin concentration was significantly lower (TC: 2.6+/-0.9 microg/mL; TT: 5.5+/-0.1 microg/mL; P<0.01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men.
Iwashima
Yoshio
Y
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
Katsuya
Tomohiro
T
Ishikawa
Kazuhiko
K
Ouchi
Noriyuki
N
Ohishi
Mitsuru
M
Sugimoto
Ken
K
Fu
Yuxiao
Y
Motone
Masaharu
M
Yamamoto
Kouichi
K
Matsuo
Akiko
A
Ohashi
Koji
K
Kihara
Shinji
S
Funahashi
Tohru
T
Rakugi
Hiromi
H
Matsuzawa
Yuji
Y
Ogihara
Toshio
T
D052242:Adiponectin; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology; D007333:Insulin Resistance / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000032:analysis* / Q000235:genetics; D012307:Risk Factors
D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D008055:Lipids; D011506:Proteins; D003404:Creatinine