title: Development of a novel polyimide hollow-fiber oxygenator.
abstract: We have developed a membrane oxygenator using a novel asymmetric polyimide hollow fiber. The hollow fibers are prepared using a dry/wet phase-inversion process. The gas transfer rates of O(2) and CO(2) through the hollow fibers are investigated in gas-gas and gas-liquid systems. The polyimide hollow fiber has an asymmetric structure characterized by the presence of macrovoids, and the outer diameter of the hollow fiber is 330 microm. It is found that the polyimide hollow-fiber oxygenator can enhance the gas transfer rates of O(2) and CO(2), and that the hollow fiber provides excellent blood compatibility in vitro and in vivo.
authors.affiliation: Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Niwa
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Shoji
authors.initials: S
authors.lastname: Nagaoka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kanamori
authors.forename: Kazuko
authors.initials: K
authors.lastname: Morisaku
authors.forename: Toshio
authors.initials: T
authors.lastname: Shinbo
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Matsuda
authors.forename: Kazunari
authors.initials: K
authors.lastname: Sakai
authors.forename: Sunao
authors.initials: S
authors.lastname: Kubota
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000378:metabolism; D004285:Dogs; D004867:Equipment Design; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000378:metabolism; D010107:Oxygenators, Membrane; D012117:Resins, Synthetic / Q000737:chemistry; D014684:Venae Cavae / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D012117:Resins, Synthetic; D002245:Carbon Dioxide; C029945:polyimide resin; D010100:Oxygen