Synthesis and anti-inflammatory effect of lipophilic derivatives of threo-DL-phenylserine in rat experimental edema.
Novel N- and O-acyl derivatives of threo-DL-phenylserine containing lipophilic long chain carboxylic or aryl(sulfon)amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 24 h.
Dirvianskyte
N
N
Institute of Biochemistry, Vilnius, Lithuania.
Leonaviciene
L
L
Bradünaite
R
R
Razumas
V
V
Butkus
E
E
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005528:Foot / Q000473:pathology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D012694:Serine; D002351:Carrageenan