Genomic profiling of peripheral T-cell lymphoma, unspecified, and anaplastic large T-cell lymphoma delineates novel recurrent chromosomal alterations.
To characterize genetic alterations in peripheral T-cell lymphoma, not otherwise specified (PTCL NOS), and anaplastic large T-cell lymphoma (ALCL), 42 PTCL NOS and 37 ALCL [17 anaplastic large cell kinase (ALK)-negative ALCL, 9 ALK-positive ALCL, 11 cutaneous ALCL] were analyzed by comparative genomic hybridization. Among 36 de novo PTCL NOS, recurrent chromosomal losses were found on chromosomes 13q (minimally overlapping region 13q21, 36% of cases), 6q and 9p (6q21 and 9p21-pter, in 31% of cases each), 10q and 12q (10q23-24 and 12q21-q22, in 28% of cases each), and 5q (5q21, 25% of cases). Recurrent gains were found on chromosome 7q22-qter (31% of cases). In 11 PTCL NOS, high-level amplifications were observed, among them 3 cases with amplification of 12p13 that was restricted to cytotoxic PTCL NOS. Whereas cutaneous ALCL and ALK-positive ALCL showed few recurrent chromosomal imbalances, ALK-negative ALCL displayed recurrent chromosomal gains of 1q (1q41-qter, 46%), and losses of 6q (6q21, 31%) and 13q (13q21-q22, 23%). Losses of chromosomes 5q, 10q, and 12q characterized a group of noncytotoxic nodal CD5+ peripheral T-cell lymphomas. The genetics of PTCL NOS and ALK-negative ALCL differ from other T-NHLs characterized genetically so far, among them enteropathy-type T-cell lymphoma, T-cell prolymphocytic leukemia, and adult T-cell lymphoma/leukemia.
Zettl
Andreas
A
Department of Pathology, University of Würzburg, Würzburg, Germany. andreas.zettl@mail.uni-wuerzburg.de
Rüdiger
Thomas
T
Konrad
Maria-Anette
MA
Chott
Andreas
A
Simonitsch-Klupp
Ingrid
I
Sonnen
Ruth
R
Müller-Hermelink
Hans Konrad
HK
Ott
German
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018956:CD5 Antigens / Q000096:biosynthesis; D045744:Cell Line, Tumor; D002648:Child; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D005260:Female; D016678:Genome; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008207:Lymphatic Metastasis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012878:Skin Neoplasms / Q000235:genetics; D013997:Time Factors
D018956:CD5 Antigens