[Yixintong tablet's protection against experimental myocardial ischemia].
OBJECTIVE
Various models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia.


METHODS
Models of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline) to check the indices of ECG, hemodynamics, and morphology.


RESULTS
A dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty-minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Yixintong tablets exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (+/- dp/dtmax), and ST segment (electrocardiogram). The tablet markedly reduced the myocardial infarct size of the coronary-ligatured rats. The tablet benefited the rats with pituitrin(iv)- or isoprenaline(ip)-induced acute myocardial ischemia to reverse any ST deviation and T-wave fall.


CONCLUSIONS
Yixintong has a protective and therapeutic action to the experimental myocardial ischemia.
Piao
Jin-hua
JH
Pharmacology Department, Shanxi Institute for Drug Control, Taiyuan 030001, Shanxi, China. Mary paio@263.net
Tong
Pei-zhi
PZ
Zhang
Hong
H
Gao
Tian-hong
TH
Zhang
Li
L
Lu
Xiang-hua
XH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D027825:Crataegus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D013607:Tablets