Artificial liver support molecular adsorbents recirculating system therapy as a bridge to re-transplantation in two cases of long anhepatic duration.
BACKGROUND
Molecular adsorbents recirculating system (MARS) liver support therapy is the development of albumin dialysis. This study was to assess the successful application of MARS artificial liver support therapy as a bridge to re-transplantation in two cases of long anhepatic duration.


METHODS
MARS therapy was given after failure plasma-exchange (PE) treatment, which resulted in circulatory derangement and acute renal dysfunction in a 36-year-old male patient. Finally his uncontrolled anhepatic condition led to a successful re-transplantation. In another 48-year-old man who was diagnosed as having primary nonfunction (PNF) during the liver transplantation, 10-hour MARS treatment contributed to smooth bridging of his anhepatic phase.


RESULTS
The two anhepatic patients were bridged for 26 and 17 hours respectively to re-transplantation with MARS therapy.


CONCLUSIONS
Our experience proves that MARS artificial liver can be an effective support for long time bridging PNF until re-transplantation is available.
Liu
Yi-He
YH
Tianjin Organ Transplantation Institute, Tianjin First Central Hospital, Tianjin 300192, China.
Wang
Yu
Y
Yu
Li-Xin
LX
Sun
Li-Ying
LY
Feng
Bao-Lan
BL
Shen
Zhong-Yang
ZY
Wang
Min-Min
MM
D000328:Adult; D006801:Humans; D017093:Liver Failure / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation / Q000009:adverse effects*; D019164:Liver, Artificial; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D013997:Time Factors; D016896:Treatment Outcome