Myoclonic status epilepticus following repeated oral ingestion of colloidal silver.
The authors report a case of a 71-year-old man who developed myoclonic status epilepticus and coma after daily ingestion of colloidal silver for 4 months resulting in high levels of silver in plasma, erythrocytes, and CSF. Despite plasmapheresis, he remained in a persistent vegetative state until his death 5.5 months later. Silver products can cause irreversible neurologic toxicity associated with poor outcome.
Mirsattari
S M
SM
Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada.
Hammond
R R
RR
Sharpe
M D
MD
Leung
F Y
FY
Young
G B
GB
D000230:Adenocarcinoma / Q000188:drug therapy*; D000284:Administration, Oral; D000368:Aged; D001129:Argyria / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002540:Cerebral Cortex / Q000737:chemistry / Q000473:pathology; D003102:Colloids / Q000008:administration & dosage / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced; D000529:Complementary Therapies / Q000009:adverse effects; D004831:Epilepsies, Myoclonic / Q000139:chemically induced*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D018458:Persistent Vegetative State / Q000139:chemically induced; D010956:Plasmapheresis; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012834:Silver / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D013226:Status Epilepticus / Q000139:chemically induced*; D017211:Treatment Failure
D003102:Colloids; D012834:Silver