A novel HLA-DRB1 allele, DRB1*0449, with a rare point mutation found in the Han population of Guangdong China.
Anovel HLA-DRB1 allele, DRB1*0449, has been identified in the Han population of Guangdong Province of China. Compared with DRB1*0406, it has only one single-nucleotide mutation from G to A at position 18 of exon 2, which causes a change in the protein sequence from valine to isoleucine at codon 11 of DR beta chain.
Lv
F
F
Department of Biochemistry, College of Life Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.
Gao
J
J
Lin
J
J
Liu
Z
Z
Fu
Y
Y
Lin
B
B
Liu
Y
Y
Xu
A
A
D000595:Amino Acid Sequence; D001483:Base Sequence; D002681:China; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C495081:HLA-DRB1*04:49 antigen