title: Use of the Vitek-1 and Vitek-2 systems for detection of constitutive and inducible macrolide resistance in group B streptococci.
abstract: A prospective study of erythromycin and clindamycin resistance was performed with 304 consecutive group B streptococci (GBS) isolates. According to two automated susceptibility testing systems, Vitek-1 and Vitek-2, and double-disk agar diffusion, 79.9% were susceptible to both erythromycin and clindamycin. However, for macrolide-lincosamide-streptogramin B-inducible isolates, the accuracies of the Vitek-1 and Vitek-2 systems were 5.6 and 94.4%. In light of these results, we recommend that GBS be routinely tested using the double-disk diffusion method.
authors.affiliation: Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, and University of Toronto, Ontario, Canada.
authors.forename: Patrick
authors.initials: P
authors.lastname: Tang
authors.forename: Peter
authors.initials: P
authors.lastname: Ng
authors.forename: Ming
authors.initials: M
authors.lastname: Lum
authors.forename: Martin
authors.initials: M
authors.lastname: Skulnick
authors.forename: Glen W
authors.initials: GW
authors.lastname: Small
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
authors.forename: Alicia
authors.initials: A
authors.lastname: Sarabia
authors.forename: Tony
authors.initials: T
authors.lastname: Mazzulli
authors.forename: Katherine
authors.initials: K
authors.lastname: Wong
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Simor
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Willey
mesh_terms: D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods* / Q000706:statistics & numerical data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013290:Streptococcal Infections / Q000150:complications / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin