title: Tumor-level serum testosterone associated with human immunodeficiency virus lipodystrophy syndrome.
abstract: BACKGROUND
  Human immunodeficiency virus (HIV) lipodystrophy syndrome consists of insulin resistance, hyperlipidemia, increased waist-to-hip ratios, and relative hyperandrogenemia, which resembles polycystic ovary syndrome.
  
  
  METHODS
  A 30-year-old HIV-positive multipara with lipodystrophy syndrome had an elevated level of serum total testosterone (244 ng/dL) in the tumor range.
  
  
  CONCLUSIONS
  In HIV lipodystrophy syndrome, marked elevations of total serum testosterone in the range reserved for androgen-producing tumors may occur. The elevated testosterone levels are derived from the ovary and are responsive to gonadotropin suppression.
authors.affiliation: Department of Obstetrics and Gynecology, Washington University in St. Louis, St. Louis, Missouri 63108-2259, USA. dahanhaim@hotmail.com
authors.forename: Michael H
authors.initials: MH
authors.lastname: Dahan
authors.forename: Larry N
authors.initials: LN
authors.lastname: Lyle
authors.forename: Ada
authors.initials: A
authors.lastname: Wolfsen
authors.forename: R Jeffrey
authors.initials: RJ
authors.lastname: Chang
mesh_terms: D000328:Adult; D005260:Female; D039682:HIV-Associated Lipodystrophy Syndrome / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007273:Injections, Intramuscular; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use; D010053:Ovary / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood*
chemical_list: D013739:Testosterone; D016729:Leuprolide