title: Solid-phase synthesis of constrained terminal and internal lactam peptidomimetics.
abstract: Lactams are key components of many peptidomimetic structures. Five- and six-membered lactam peptidomimetics with hydrogen or amino acid side chains at the alpha-position can be constructed from peptide precursors during a solid-phase synthesis. There is no significant racemization of remote stereocenters during synthesis.
authors.affiliation: Department of Chemistry, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA. wscott@chem.iupui.edu
authors.forename: William L
authors.initials: WL
authors.lastname: Scott
authors.forename: Jordi
authors.initials: J
authors.lastname: Alsina
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Kennedy
authors.forename: Martin J
authors.initials: MJ
authors.lastname: O'Donnell
mesh_terms: D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D018716:Molecular Mimicry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D007769:Lactams; D010456:Peptides, Cyclic