title: Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides.
abstract: A series of novel 6-O-arylpropargyl-9-oxime-ketolides was synthesized and evaluated against various pathogens. These new compounds show promising in vitro antibacterial potency and in vivo efficacy against macrolide resistant strains.
authors.affiliation: Infectious Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA. xenia.b.searle@abbott.com
authors.forename: Xenia
authors.initials: X
authors.lastname: Beebe
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Mai H
authors.initials: MH
authors.lastname: Bui
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mitten
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Ma
authors.forename: Angela M
authors.initials: AM
authors.lastname: Nilius
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D006193:Haemophilus influenzae / Q000187:drug effects; D048628:Ketolides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D018942:Macrolides; D051381:Rats; D012141:Respiratory Tract Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides