title: Cyclosporine monitoring in stable, long-term, pediatric kidney transplant recipients: the value of C2 determination.
abstract: Although a generalized consensus has been reached for therapeutic drug monitoring of cyclosporine microemulsion in adult transplant patients, clear guidelines are recently not available for the pediatric population. In this retrospective analysis of pharmacokinetic data obtained from stable, long-term, pediatric kidney transplant recipients, we sought to define a possible approach to manage cyclosporine therapy in a pediatric setting. The 2-hour postdose cyclosporine blood concentration, C(2), rather than trough levels, was the best single time point predictor of the area under the concentration curve. We concluded that therapeutic drug monitoring of cyclosporine-based immunosuppressive regimens should be tailored based on C(2) determinations for pediatric kidney transplant recipients.
authors.affiliation: Division of Vascular Surgery and Kidney Transplant, Ospedale Maggiore--Policlinico, IRCCS, Milan, Italy. mario.ferraresso@unimi.it
authors.forename: M
authors.initials: M
authors.lastname: Ferraresso
authors.forename: L
authors.initials: L
authors.lastname: Ghio
authors.forename: S
authors.initials: S
authors.lastname: Tirelli
authors.forename: P
authors.initials: P
authors.lastname: Pedotti
authors.forename: E
authors.initials: E
authors.lastname: Taioli
authors.forename: A
authors.initials: A
authors.lastname: Edefonti
authors.forename: L
authors.initials: L
authors.lastname: Berardinelli
mesh_terms: D019540:Area Under Curve; D002648:Child; D016572:Cyclosporine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008657:Metabolic Clearance Rate
chemical_list: D016572:Cyclosporine