title: [Results of the first 1,000 consecutive elective nonmechanical keratoplasties using the excimer laser. A prospective study over more than 12 years].
abstract: OBJECTIVE
  The purpose of this prospective clinical cross-sectional study was to analyse indications, intraoperative, perioperative and postoperative pecularities and complications as well as postoperative functional and morphologic results of the first 1000 consecutive elective round laser keratoplasties.
  
  
  METHODS
  The age of the 480 females and 520 males (362 x keratoconus), who had been operated on between 07/1989 and 04/2002 ranged from 20 to 92 years (mean 55+/-19). A total of 6 microsurgeons performed 718 x PK only, 222 x a triple procedure and 60 x additional IOL manoeuvres. Recipient and donor trephinations were accomplished with an 193 nm excimer laser (Carl Zeiss Meditec, Jena, Germany) from the epithelial side.
  
  
  RESULTS
  In 895 eyes with perioperative corneal erosion, epithelial healing took not more than 3 days in half of cases. During a follow-up period of 1.9+/-1.5 years, in 35 eyes episodes of acute diffuse (8 irreversible) and in 12 eyes episodes of chronic focal (5 irreversible) endothelial immunologic graft reactions (4.7%) occurred between 6 weeks and 4.7 years after PK. Before/after suture removal, median values of astigmatism were 1.5 diopters (D)/2.5 D refractive, 3.0 D/3.3 D keratometric, and 4.0 D/4.2 D topographic. Best-corrected visual acuity was 0.50/0.60, respectively.
  
  
  CONCLUSIONS
  More than 12 years of experience with this new technique indicate that besides optical advantages, nonmechanical trephination does not cause intraoperative or postoperative disadvantages for the patient. Under standardised surgical conditions a massive increase of astigmatism after suture removal seems to be avoidable with laser trephination in most cases due to reduction of decentration,"vertical tilt" and especially "horizontal torsion".
authors.affiliation: Augenklinik mit Poliklinik der Universität Erlangen-Nürnberg, Erlangen. berthold.seitz@augen.imed.uni-erlangen.de
authors.forename: B
authors.initials: B
authors.lastname: Seitz
authors.forename: A
authors.initials: A
authors.lastname: Langenbucher
authors.forename: N X
authors.initials: NX
authors.lastname: Nguyen
authors.forename: M M
authors.initials: MM
authors.lastname: Kus
authors.forename: M
authors.initials: M
authors.lastname: Küchle
authors.forename: G O H
authors.initials: GO
authors.lastname: Naumann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016039:Corneal Transplantation / Q000379:methods* / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D017558:Elective Surgical Procedures / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D018903:Photorefractive Keratectomy / Q000379:methods* / Q000706:statistics & numerical data*; D020127:Recovery of Function; D012030:Refractive Errors / Q000453:epidemiology*; D054140:Refractive Surgical Procedures; D016896:Treatment Outcome