[Radiotherapy of carcinomas of the anal canal. Tenon Hospital experience].
Since 1980, curative-intent radiation therapy of epidermoid carcinoma of the anal canal is the standard first line treatment. The combined concomitant chemotherapy and radiation therapy is presently established for locally advanced tumors more than 4 cm in length and/or with nodal involvement. We report the Tenon hospital experience since 1972 concerning the long term results after radiation therapy, the modifications of the radiation technique, and the evolution of treatment strategy.
Touboul
E
E
Service d'oncologie-radiothérapie, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France. emmanuel.touboul@tnn.ap-hop-paris.fr
Moureau-Zabotto
L
L
Lerouge
D
D
Pène
F
F
Deniaud-Alexandre
E
E
Tiret
E
E
Sezeur
A
A
Houry
S
S
Gallot
D
D
Parc
R
R
Schlienger
M
M
Laugier
A
A
D000368:Aged; D001003:Anal Canal / Q000473:pathology; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001005:Anus Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007496:Iridium Radioisotopes; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010315:Particle Accelerators; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013997:Time Factors
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D007496:Iridium Radioisotopes; D002945:Cisplatin; D005472:Fluorouracil