[Obesity studies in candidate genes].
There are more than 430 chromosomic regions with gene variants involved in body weight regulation and obesity development. Polymorphisms in genes related to energy expenditure--uncoupling proteins (UCPs), related to adipogenesis and insulin resistance--hormone-sensitive lipase (HLS), peroxisome proliferator-activated receptor gamma (PPAR gamma), beta adrenergic receptors (ADRB2,3), and alfa tumor necrosis factor (TNF-alpha), and related to food intake--ghrelin (GHRL)--appear to be associated with obesity phenotypes. Obesity risk depends on two factors: a) genetic variants in candidate genes, and b) biographical exposure to environmental risk factors. It is necessary to perform new studies, with appropriate control groups and designs, in order to reach relevant conclusions with regard to gene/environmental (diet, lifestyle) interactions.
Ochoa
María del Carmen
Mdel C
Departamento de Fisiología y Nutrición, Universidad de Navarra, Pamplona, Spain.
Martí
Amelia
A
Martínez
J Alfredo
JA
D000273:Adipose Tissue / Q000378:metabolism; D002986:Clinical Trials as Topic; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D011110:Polymorphism, Genetic