[Sulfur dioxide-induced liver pathology].
OBJECTIVE
To investigate effects of short-term sulfur dioxide inhalation to the liver.


METHODS
Haematoxylin and eosin staining (HE) and transmission electron microscopy (TEM) were used to study the pathologic changes in mice liver after sulfur dioxide (SO(2)) inhalation.


RESULTS
Exposure to 56 mg/m(3), 112 mg/m(3) 168 mg/m(3) SO(2) caused increasingly severe liver injuries, as detected by HE staining and TEM. The morphologic changes included spotty necrosis with lymphocyte, monocyte, and neutrophil infiltration, fatty degeneration of hepatocytes with dilatation of rough endoplasmic reticulum and dissociation of ribosomes, as well as degeneration of mitochondria and karyorrhexis.


CONCLUSIONS
SO(2) inhalation can cause marked liver injury in experimental settings.
Bai
Jian-ying
JY
Institute of Environmental Medicine and Toxicology, School of Life Science and Technology, Shanxi University, Taiyuan 030006, China.
Meng
Zi-qiang
ZQ
D000280:Administration, Inhalation; D000818:Animals; D022781:Hepatocytes / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*
D013458:Sulfur Dioxide