title: Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.
abstract: The polymer-assisted solution-phase (PASP) synthesis of a 192-member 2-D array of 1,5-biaryl pyrazoles 4[1-12,1-16] is reported. The synthesis was performed in a fully automated manner using a multiprobe top-filtration robot and incorporates a "catch and release" step to afford library compounds directly in high yield and purity.
authors.affiliation: GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Vickerstaffe
authors.forename: Brian H
authors.initials: BH
authors.lastname: Warrington
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009930:Organic Chemicals; D011108:Polymers; D011720:Pyrazoles; D012996:Solutions
chemical_list: D009930:Organic Chemicals; D011108:Polymers; D011720:Pyrazoles; D012996:Solutions