[Protective effect of qi dong yi xin on acute myocardial infarction in dogs].
OBJECTIVE
To observe the protective effects on acute myocardial infarction of QDYX in dog.


METHODS
The corconary ciculation and cardial oxygen metabolism, the degree and range of myocardial ischemia, myocardial infarct size, and the changes of the enzymes in serum were determined by using the acute myocardial infarction model of ligation of LAD in the anaesthetized open-chest dogs.


RESULTS
The coronary resistance and cardial oxygen consumption were decreased and the myocardial blood flow was increased in dogs treated with QDYX of 1.0,2.0 mg.kg-1. The degree and range of myocardial ischemia, myocardial infarct size and the activity of serum CK, LDH were decreased in acute myocardial infarcion dogs treated with QDYX of 1.0,2.0 mg.kg-1.


CONCLUSIONS
QDYX can decrease cardial oxygen consumption in dogs, thus having protective effect on myocardial ischemia.
Wang
Qiu-jing
QJ
School of Badic Medical Sciences, Jilin University, Changchun 130021, Jilin, China.
Lu
Weng-wei
WW
Lu
Hang
H
Liu
Fen
F
Yang
Shi-jie
SJ
Hua
Yu-qiang
YQ
Ji
Shu-xia
SX
D000284:Administration, Oral; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D031441:Ophiopogon / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry
D002316:Cardiotonic Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal