A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct alpha-alkylation of nitriles with primary alcohols.
Treatment of a hydrotacite, Mg6Al2(OH)16CO3, with an aqueous solution of RuCl3.nH2O afforded a monomeric Ru(IV) species on the surface of the hydrotalcite. This novel Ru-grafted hydrotalcite (Ru/HT) efficiently catalyzed alpha-alkylation of nitriles with primary alcohols through the cooperative catalysis between the Ru species and the surface base sites. The catalyst system could be further extended for the one-pot synthesis of alpha,alpha-dialkylated phenylacetonitriles via the base-catalyzed Michael reaction of alpha-alkylated phenylacetonitrile with activate olefins.
Motokura
Ken
K
Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
Nishimura
Daisuke
D
Mori
Kohsuke
K
Mizugaki
Tomoo
T
Ebitani
Kohki
K
Kaneda
Kiyotomi
K