title: HLA-A*24020102L in the UK blood donor population.
abstract: The low-expression allele HLA-A*24020102L was identified on a likely haplotype bearing B*55, Cw*01 during the investigation of nine cases (four families and five unrelated subjects) of HLA-A*24 lacking the A24 specificity. A search was made of 70,007 HLA-A, HLA-B, and HLA-C DNA-based typed largely northwestern European Caucasoid blood donors on the British Bone Marrow Registry and Welsh Bone Marrow Donor Registry panels for phenotypes possessing A*24, B*55, Cw*01. Fifty three were found, and 12 of these were subsequently shown to possess A*24020102L by sequence-based typing or polymerase chain reaction with sequence-specific primers. This indicated that the likely A*24, B*55, Cw*01 haplotype has a frequency of 0.000378 in the UK and that approximately 22.6% of these will possess A*24020102L. Consequently, HLA-A*24020102L, B*55, Cw*01 is a principal A*24020102L-bearing haplotype, and the minimum carriage and gene frequencies of A*24020102L are 0.017% and 0.000086, respectively, in UK blood donors.
authors.affiliation: British Bone Marrow Registry, DNA Reference Laboratory, National Blood Service, Bristol, UK. paul.dunn@nbs.nhs.uk
authors.forename: P P J
authors.initials: PP
authors.lastname: Dunn
authors.forename: J R
authors.initials: JR
authors.lastname: Turton
authors.forename: J
authors.initials: J
authors.lastname: Downing
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: C V
authors.initials: CV
authors.lastname: Navarrete
authors.forename: C
authors.initials: C
authors.lastname: Darke
mesh_terms: D001782:Blood Donors; D015234:HLA-A Antigens / Q000235:genetics*; D059871:HLA-A24 Antigen; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D015234:HLA-A Antigens; C495070:HLA-A*24:02:01:02L antigen; D059871:HLA-A24 Antigen