Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase.
Although allopurinol has been available for approximately 50 years, hyperuricemia and its sequelae are not only prevalent, but the incidence and costs associated with this disorder continue to increase. However, several new therapies have been developed. Recombinant urate oxidase has been useful in the treatment of tumor lysis hyperuricemia, and pegylated urate oxidase shows promise in patients with hyperuricemia and gout. Febuxostat and Y-700 are new oral xanthine oxidase inhibitors that are in human clinical trials. Tailoring of antilipid therapy in selected hyperuricemic and hyperlipidemic patients with fenofibrate may be of benefit in lowering blood cholesterol and uric acid levels. Similarly, treatment of selected hyperuricemic patients who also are hypertensive with losartan or amlodipine may be beneficial in lowering blood pressure and hyperuricemia. Despite these advances, new treatments for hyperuricemia are needed.
Bomalaski
John S
JS
Medical College of Pennsylvania Hospital, Drexel University College of Medicine, 3300 Henry Avenue, Philadelphia, PA 19129, USA. johnsbomalaski@msn.com
Clark
Mike A
MA
D000493:Allopurinol / Q000627:therapeutic use; D017311:Amlodipine / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D000069465:Febuxostat; D006073:Gout / Q000188:drug therapy; D006801:Humans; D033461:Hyperuricemia / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use; D011720:Pyrazoles / Q000627:therapeutic use*; D013844:Thiazoles / Q000627:therapeutic use; D016896:Treatment Outcome; D014503:Urate Oxidase / Q000627:therapeutic use*; D014527:Uric Acid / Q000037:antagonists & inhibitors / Q000097:blood*; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
C433950:1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid; D004791:Enzyme Inhibitors; D011720:Pyrazoles; D013844:Thiazoles; D000069465:Febuxostat; D017311:Amlodipine; D014527:Uric Acid; D000493:Allopurinol; D014969:Xanthine Oxidase; D014503:Urate Oxidase; D019808:Losartan