Lipid raft domains and protein networks in T-cell receptor signal transduction.
Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as tyrosine phosphorylations, ras activation and induction of Ca(2+) fluxes, are initiated in the T-cell plasma membrane. It has been implicated that cholesterol- and sphingolipid-rich membrane domains, termed lipid rafts, form platforms for the regulation and transduction of TCR signals at the plasma membrane; however, recent experiments have now differentiated distinct roles for lipid-raft-mediated and protein-mediated interactions in the formation of TCR signalling membrane domains.
Harder
Thomas
T
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. thomas.harder@path.ox.ac.uk
D000818:Animals; D006801:Humans; D008563:Membrane Lipids / Q000276:immunology; D021962:Membrane Microdomains / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D008563:Membrane Lipids; D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell