title: Reversal of an antihistamine-induced coma with flumazenil.
abstract: Flumazenil is a competitive antagonist with specific action at the central benzodiazepine receptor. It is used when benzodiazepine intoxication is suspected. Its use has also been reported in cannabis intoxication, chloral hydrate overdose, hepatic encephalopathy, and alcohol intoxication. We report the case of a 7-month-old male infant with a depressed level of consciousness after intentional intoxication of antihistamines, whose mental status fully recovered after administration of flumazenil. To our knowledge, this is the first case in children where flumazenil has been reported to reverse antihistamine-induced coma.
authors.affiliation: Department of Pediatrics, Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain. lassaalvaro@yahoo.com
authors.forename: Alvaro
authors.initials: A
authors.lastname: Lassaletta
authors.forename: Ricardo
authors.initials: R
authors.lastname: Martino
authors.forename: Pilar
authors.initials: P
authors.lastname: Gónzalez-Santiago
authors.forename: Carmen
authors.initials: C
authors.lastname: Torrijos
authors.forename: Margarita
authors.initials: M
authors.lastname: Cebrero
authors.forename: Enrique
authors.initials: E
authors.lastname: García-Frías
mesh_terms: D002649:Child Abuse; D003128:Coma / Q000139:chemically induced / Q000188:drug therapy*; D004155:Diphenhydramine / Q000097:blood / Q000506:poisoning* / Q000652:urine; D005442:Flumazenil / Q000627:therapeutic use*; D058787:GABA-A Receptor Antagonists; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning*; D007223:Infant; D008297:Male; D014291:Trimeprazine / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning* / Q000652:urine
chemical_list: D058787:GABA-A Receptor Antagonists; D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; D005442:Flumazenil; D014291:Trimeprazine; D004155:Diphenhydramine