title: An 82Rb infusion system for quantitative perfusion imaging with 3D PET.
abstract: A (82)Rb infusion system is described with two important features for imaging with 3D positron emission tomography. First, a generator bypass line is added to flush the patient infusion line at the end of an elution. Second, feedback control is implemented to permit 'slow-bolus' constant-activity elutions. A model for the activity eluted from a (82)Sr/(82)Rb generator based on a volume-activity empirical relationship, is used as the basis for performing simulations to demonstrate the efficacy of varying the flow rate through the generator to achieve desired eluted (82)Rb activity rate profiles. A (82)Rb infusion system was constructed to verify the accuracy of the simulations. The system can deliver accurate constant-activity elutions from 10% to 70% of the total generator activity.
authors.affiliation: National Cardiac P.E.T. Centre University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ont., Canada K1Y 4W7.
authors.forename: Neil
authors.initials: N
authors.lastname: J  Epstein
authors.forename: Ahmed
authors.initials: A
authors.lastname: Benelfassi
authors.forename: Rob
authors.initials: R
authors.lastname: S B  Beanlands
authors.forename: R A Robert A
authors.initials: RA
authors.lastname: DeKemp
mesh_terms: D003327:Coronary Disease / Q000000981:diagnostic imaging; D006801:Humans; D007262:Infusions, Intravenous; D010477:Perfusion; D015203:Reproducibility of Results; D012414:Rubidium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D012414:Rubidium Radioisotopes