title: The modular approach to ligand discovery.
abstract: Identifying specific protein-ligand interactions is a long-standing problem in drug discovery and chemical biology, which is only exacerbated by the abundance of uncharacterized proteins revealed by genomics. Last month in Chemistry Biology, Sem et al. described a powerful technique for rapidly screening protein families for ligands.
authors.affiliation: Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Room 622, Boston, MA 02115, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Karan
authors.forename: John A
authors.initials: JA
authors.lastname: Tallarico
mesh_terms: D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008024:Ligands; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*
chemical_list: D008024:Ligands; D011506:Proteins