Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.
Most viruses exploit a variety of host cellular proteins as primary cellular attachment receptors in the context of successful execution of infection. Furthermore, many viral agents have evolved precise mechanisms to subvert host immune recognition to achieve persistence. Herein we present data indicating that adenovirus (Ad) serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. CD80 and CD86 are co-stimulatory molecules that are present on mature dendritic cells and B lymphocytes and are involved in stimulating T-lymphocyte activation. To our knowledge, this is one of the first demonstrations of a virus utilizing immunologic accessory molecules as a primary means of cellular entry. This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system.
Short
Joshua J
JJ
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-2172, USA.
Pereboev
Alexander V
AV
Kawakami
Yosuke
Y
Vasu
Chenthamarakshan
C
Holterman
Mark J
MJ
Curiel
David T
DT
D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018122:B7-1 Antigen / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051940:B7-2 Antigen; D016466:CHO Cells; D006224:Cricetinae; D003713:Dendritic Cells / Q000821:virology; D005822:Genetic Vectors; D006367:HeLa Cells; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism; D015800:Protozoan Proteins; D012703:Serotyping
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497964:CD86 protein, human; D008562:Membrane Glycoproteins; D010455:Peptides; D015800:Protozoan Proteins; C042968:knob protein, Plasmodium falciparum