[Serological study of a repertoire of human cancer antigens and autoantigens].
The spectrum of human antigens allows a monitoring of various pathological processes such as autoimmune disorders and tumorigenesis. Serological analysis of cDNA expression libraries (SEREX) is now used to search for new cancer-associated antigens, which are potential diagnostic markers or targets for immunotherapy of cancer. The results obtained for several solid tumors are reviewed. Groups of antigens detectable by SEREX, causes of immunogenicity of autoantigens, and prospective implication of antigens in diagnostics and monitoring of cancer are discussed.
Koroleva
E P
EP
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.
Lagar'kova
M A
MA
Khlgatian
S V
SV
Shebzukhov
Iu V
IuV
Meshcheriakov
A A
AA
lichinitser
M R
MR
Nedospasov
S A
SA
Kuprash
D V
DV
D000951:Antigens, Neoplasm / Q000097:blood*; D001324:Autoantigens / Q000097:blood*; D006801:Humans; D008991:Monitoring, Physiologic; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology
D000951:Antigens, Neoplasm; D001324:Autoantigens