Molecular release from a polymeric microreservoir device: Influence of chemistry, polymer swelling, and loading on device performance.
A polymeric microreservoir device for controlled-release drug delivery relies on the degradation of thin poly(lactic-co-glycolic acid) membranes that seal each reservoir to achieve pulsatile drug delivery. In vitro release studies in which the swelling of the reservoir membranes was measured indicate a correlation between the release times of various radiolabeled molecules from the devices and the time at which the maximum membrane swelling was observed. Varying the chemistry (lipophilicity/hydrophilicity) or molecular weight of the molecules loaded into the devices did not appear to affect the degree of membrane swelling that was observed, or the time at which the molecules were released from the devices. The amount of drug that was loaded into the reservoirs also did not appear to affect the observed release time of the drug from the device, a significant departure from the behavior of many matrix-type polymeric drug delivery systems.
Richards Grayson
Amy C
AC
Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139.
Cima
Michael J
MJ
Langer
Robert
R
D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D003911:Dextrans / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems; D004343:Drug Implants; D005947:Glucose / Q000031:analogs & derivatives / Q000378:metabolism; D006016:Glycolates / Q000737:chemistry / Q000378:metabolism; D019344:Lactic Acid; D008422:Materials Testing; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D003911:Dextrans; D004343:Drug Implants; D006016:Glycolates; D011108:Polymers; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005947:Glucose