Effects of, and corrections for, cross-term interactions in Q-space MRI.
The present study assesses the effects of cross-term interactions between diffusion and imaging gradients in magnetic resonance imaging q-space analysis, and corrects for those effects for both spin echo and stimulated echo diffusion-weighted sequences. These corrections are demonstrated experimentally in unrestricted media for water and theoretically by simulating the case of restricted diffusion in a sphere. By correcting for the cross-term interactions, large imaging gradients can be used without compromising the results. Ignoring cross-term interactions could lead to a misunderstanding of the q-space analysis; for instance, the microstructural size of the sample could be overestimated, or isotropic media could be misinterpreted as being anisotropic.
Brihuega-Moreno
Oscar
O
Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge School of Clinical Medicine, University Forvie Site, Cambridge, UK.
Heese
Frank P
FP
Tejos
Cristián
C
Hall
Laurance D
LD
D038524:Diffusion Magnetic Resonance Imaging; D008962:Models, Theoretical; D019047:Phantoms, Imaging