title: Antibiotics in older adults.
abstract: Antibiotics are frequently prescribed in the older person, the dosification needs special care, since the pharmacokinetic parameters changes with aging and the side effects can be different in the older person. The creatinine clearance changes and we must modify the way we prescribe such antibiotics to the elderly, calculating. The variety of antibiotics now available led us to consider this paper in which we have presented the antimicrobial agents that can be considered in the treatment of the older person. We present several groups: the penicillins, cephalosporins, monobactams, carbapenems and betalactamase inhibitors or the great betalactam group. Other trimetroprin-sulfame-thoxazole, the newer macrolides (azithromycin and clarithromycin) as well as the aminoglycosides, vancomycin, clindamycin, metroridazole. The indications and contraindications are presented and reviewed.
authors.affiliation: Infectious Diseases Program, San Juan Veterans Affairs Medical Center and the Department of Medicine, University Hospital, Medical Sciences Campus, University of Puerto Rico, San Juan P.R.
authors.forename: María C
authors.initials: MC
authors.lastname: Rodríguez-Julbe
authors.forename: Carlos H
authors.initials: CH
authors.lastname: Ramírez-Ronda
authors.forename: Elba
authors.initials: E
authors.lastname: Arroyo
authors.forename: Gisela
authors.initials: G
authors.lastname: Maldonado
authors.forename: Sonia
authors.initials: S
authors.lastname: Saavedra
authors.forename: Bebelin
authors.initials: B
authors.lastname: Meléndez
authors.forename: Glenda
authors.initials: G
authors.lastname: González
authors.forename: Javier
authors.initials: J
authors.lastname: Figueroa
mesh_terms: D000367:Age Factors; D000368:Aged; D000617:Aminoglycosides / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000627:therapeutic use; D015780:Carbapenems / Q000008:administration & dosage / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use; D004347:Drug Interactions; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D008997:Monobactams / Q000008:administration & dosage / Q000627:therapeutic use; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use; D065093:beta-Lactamase Inhibitors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000892:Anti-Infective Agents, Urinary; D015780:Carbapenems; D002511:Cephalosporins; D024841:Fluoroquinolones; D018942:Macrolides; D008997:Monobactams; D010406:Penicillins; D065093:beta-Lactamase Inhibitors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination