Unintended smallpox vaccination of HIV-1-infected individuals in the United States military.
We identified 10 individuals who had undiagnosed human immunodeficiency virus type 1 (HIV-1) infection at the time of smallpox vaccination. Mean CD4 cell count was 483 cells/mm3 (range, 286-751 cells/mm3), and mean log10 plasma HIV-1 RNA load was 4.13 copies/cm3 (range, 2.54-5.16 copies/cm3). All vaccinees (3 primary and 7 repeat) had a normal, robust reaction without complications. Smallpox vaccine was well-tolerated in this small series of HIV-1-infected military personnel.
Tasker
Sybil A
SA
Department of Infectious Diseases, National Naval Medical Center, Bethesda, Maryland 20889, USA. satasker@bethesda.med.navy.mil
Schnepf
Glenn A
GA
Lim
Matthew
M
Caraviello
Harold E
HE
Armstrong
Adam
A
Bavaro
Mary
M
Agan
Brian K
BK
Delmar
Judith
J
Aronson
Naomi
N
Wallace
Mark R
MR
Grabenstein
John D
JD
D000328:Adult; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000276:immunology* / Q000628:therapy; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D012367:RNA, Viral / Q000097:blood* / Q000187:drug effects; D012900:Smallpox Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D014481:United States; D014611:Vaccination
D012367:RNA, Viral; D012900:Smallpox Vaccine