Bielschowskysin, a gorgonian-derived biologically active diterpene with an unprecedented carbon skeleton.
Bielschowskysin is a naturally occurring diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos. Its highly oxygenated hexacyclic structure is based on a previously undescribed tricyclo[9.3.0.0(2,10)]tetradecane ring system that was established through spectroscopic analysis and X-ray crystallographic analysis. Bielschowskysin was shown to exhibit antimalarial activity against Plasmodium falciparum as well as strong anticancer activity against two human cancer cell lines.
Marrero
Jeffrey
J
Department of Chemistry, University of Puerto Rico, PO Box 23346, U.P.R. Station, San Juan, Puerto Rico 00931-3346.
Rodríguez
Abimael D
AD
Baran
Peter
P
Raptis
Raphael G
RG
Sánchez
Juan A
JA
Ortega-Barria
Eduardo
E
Capson
Todd L
TL
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D000970:Antineoplastic Agents; D004224:Diterpenes; C494537:bielschowskysin