title: A review of treatments for macular degeneration: a synopsis of currently approved treatments and ongoing clinical trials.
abstract: OBJECTIVE
  The purpose of this report is to review recent literature and ongoing clinical trials of the treatment of neovascular age-related macular degeneration.
  
  
  RESULTS
  Advances in the understanding of the pathogenesis of age-related macular degeneration and choroidal neovascularization have resulted in the emergence of pharmacotherapies targeting various aspects of angiogenesis. Preliminary results with the new agents have been encouraging. Moreover, longer follow-up and subgroup analyses of the Treatment of Age-Related Macular Degeneration with Photodynamic Therapy and Verteporfin in Photodynamic Therapy studies have suggested new potential indications for photodynamic therapy.
  
  
  CONCLUSIONS
  Currently a patient with wet macular degeneration may have multiple investigational options that were unavailable several years ago. Ongoing clinical trials are aimed at determining the long-term safety and efficacy of these new pharmacologic and combination therapy modalities.
authors.affiliation: Retina Service, Wills Eye Hospital, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
authors.forename: Mimi
authors.initials: M
authors.lastname: Liu
authors.forename: Carl D
authors.initials: CD
authors.lastname: Regillo
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D020256:Choroidal Neovascularization / Q000150:complications / Q000628:therapy; D002986:Clinical Trials as Topic; D006801:Humans; D006979:Hyperthermia, Induced; D008268:Macular Degeneration / Q000209:etiology / Q000628:therapy*; D013508:Ophthalmologic Surgical Procedures; D010778:Photochemotherapy
chemical_list: D020533:Angiogenesis Inhibitors