title: SANDO: another presentation of mitochondrial disease.
abstract: OBJECTIVE
  To describe a unique mitochondrial syndrome that may present with the combination of ocular manifestations, sensory symptoms, and speech dysfunction.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Case report and review of the literature.
  
  
  RESULTS
  A 43-year-old man presented with a Sensory Ataxic Neuropathy, Dysarthria, and Ophthalmoparesis (SANDO). Nerve conduction studies showed a sensory ganglionopathy. Skeletal muscle biopsy revealed ragged red fibers, and polymerase chain reaction analysis of the tissue demonstrated multiple mitochondrial DNA deletions.
  
  
  CONCLUSIONS
  Mitochondrial disease should be considered in cases of external ophthalmoplegia, especially if a sensory ganglionopathy and dysarthria are present.
authors.affiliation: Department of Neurology, University of Florida College of Medicine, Box 100284, Gainesville, FL 32610, USA.
authors.forename: Michael S
authors.initials: MS
authors.lastname: Okun
authors.forename: M Tariq
authors.initials: MT
authors.lastname: Bhatti
mesh_terms: D000328:Adult; D001259:Ataxia / Q000175:diagnosis* / Q000235:genetics; D001706:Biopsy; D004272:DNA, Mitochondrial / Q000235:genetics; D004401:Dysarthria / Q000175:diagnosis* / Q000235:genetics; D005133:Eye Movements; D017950:Ganglia, Sensory / Q000473:pathology*; D006801:Humans; D008297:Male; D008931:Mitochondria, Muscle / Q000473:pathology; D017240:Mitochondrial Myopathies / Q000175:diagnosis* / Q000235:genetics; D018482:Muscle, Skeletal / Q000473:pathology; D009431:Neural Conduction; D017246:Ophthalmoplegia, Chronic Progressive External / Q000175:diagnosis* / Q000235:genetics; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis* / Q000235:genetics; D016133:Polymerase Chain Reaction; D013577:Syndrome
chemical_list: D004272:DNA, Mitochondrial