title: Future vaccines against emerging encephalitides.
abstract: The vaccine strategies available for control of emerging encephalitides range in a continuum from traditional approaches to those utilizing new technologies. In this report, we explore the use of live attenuated vaccines where the attenuating mutations have been selected in a rational way to improve attenuation without sacrificing effectiveness. A strategy for paired lethal and resuscitating mutations is presented that will greatly reduce the possibility of reversion to virulence. Finally, we describe an example of a vaccine vector system that could be rapidly adapted for use against these virus diseases as they emerge.
authors.affiliation: Carolina Vaccine Institute, University of North Carolina, Chapel Hill, North Carolina 27599-7292, USA. robert_johnston@med.unc.edu
authors.forename: R E
authors.initials: RE
authors.lastname: Johnston
authors.forename: N L
authors.initials: NL
authors.lastname: Davis
mesh_terms: D000818:Animals; D015195:Drug Design; D018792:Encephalitis, Viral / Q000276:immunology*; D006801:Humans; D017354:Point Mutation; D014611:Vaccination / Q000639:trends; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000235:genetics / Q000627:therapeutic use*; D014779:Virus Replication
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines