Unprecedented copper-catalyzed asymmetric conjugate addition of organometallic reagents to alpha,beta-unsaturated lactams.
For the first time, an excellent enantioselectivity has been obtained in the conjugate addition of hard organometallic reagents to alpha,beta-unsaturated lactams bearing appropriate protecting-activating groups on the nitrogen.
Pineschi
Mauro
M
Dipartimento di Chimica Bioorganica e Biofarmacia, Universita di Pisa, Via Bonanno 33, 56126 Pisa, Italy. pineschi@farm.unipi.it
Del Moro
Federica
F
Gini
Francesca
F
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL
D002384:Catalysis; D003300:Copper / Q000737:chemistry / Q000378:metabolism*; D007769:Lactams / Q000737:chemistry / Q000378:metabolism*; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*
D007769:Lactams; D009942:Organometallic Compounds; D003300:Copper