title: Synthesis of benzophenone oxime analogues as inhibitor of secretory phospholipase A(2) with anti-inflammatory activity.
abstract: The title compound have been synthesized and tested for structure activity relationship for Phospholipase A(2) (PLA(2)) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA(2) enzyme inhibitory activity of benzophenone oxime analogue and in vivo anti-inflammatory activity studies using mice are highlighted.
authors.affiliation: Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore 570006, India.
authors.forename: Satish Kumar
authors.initials: SK
authors.lastname: Murari
authors.forename: Shimoga Nagaraj
authors.initials: SN
authors.lastname: Sriharsha
authors.forename: Sheena
authors.initials: S
authors.lastname: Shashikanth
authors.forename: Bannikuppe Sannanaik
authors.initials: BS
authors.lastname: Vishwanath
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001577:Benzophenones; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D010091:Oximes / Q000138:chemical synthesis / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D001577:Benzophenones; D004791:Enzyme Inhibitors; D010091:Oximes; C047723:benzophenone; D010741:Phospholipases A