title: Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices.
abstract: Enediyne model compounds possessing photo-triggering devices were developed. These enediynes afforded biradicals by UV irradiation and showed DNA cleaving activity. The DNA damage was confirmed to be mainly caused by the biradical, not singlet oxygen.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi 1-78, Tokushima, Japan. isuzuki@ph.tokushima-u.ac.jp
authors.forename: Ichiro
authors.initials: I
authors.lastname: Suzuki
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Uno
authors.forename: Yuko
authors.initials: Y
authors.lastname: Tsuchiya
authors.forename: Akira
authors.initials: A
authors.lastname: Shigenaga
authors.forename: Hisao
authors.initials: H
authors.lastname: Nemoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shibuya
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects; D053281:Enediynes; D005609:Free Radicals; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010782:Photolysis; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
chemical_list: D000480:Alkynes; D053281:Enediynes; D005609:Free Radicals; D006841:Hydrocarbons, Aromatic; D009574:Nitro Compounds; D017319:Photosensitizing Agents; D011743:Pyrimidines; C418567:enediynone