title: Synthesis and biological activity of some structural modifications of pancratistatin.
abstract: Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
authors.forename: Uwe
authors.initials: U
authors.lastname: Rinner
authors.forename: Heather L
authors.initials: HL
authors.lastname: Hillebrenner
authors.forename: David R
authors.initials: DR
authors.lastname: Adams
authors.forename: Tomas
authors.initials: T
authors.lastname: Hudlicky
authors.forename: George R
authors.initials: GR
authors.lastname: Pettit
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D047151:Amaryllidaceae Alkaloids; D000970:Antineoplastic Agents; D007546:Isoquinolines; C044997:pancratistatin