title: Efficacy of pyrimethamine-sulfadoxine in young children with uncomplicated falciparum malaria in rural Burkina Faso.
abstract: The efficacy of pyrimethamine-sulfadoxine in the treatment of uncomplicated falciparum malaria in young children of a malaria holoendemic area in rural Burkina Faso is reported. Of 28 children treated with a standard single dose of pyrimethamine-sulfadoxine and followed-up over 14 days, only one Late Treatment Failure and four Late Parasitological Failures were observed, all with low-grade parasitaemia. In this area of very restricted use of pyrimethamine-sulfadoxine, the drug appears to be still sufficiently effective in the treatment of malaria. These findings provide further evidence for the justification of continued use of pyrimethamine-sulfadoxine as a second-line treatment for malaria in Burkina Faso.
authors.affiliation: Department of Tropical Hygiene and Public Health of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. olaf.mueller@urz.uni-heidelberg.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Müller
authors.forename: Corneille
authors.initials: C
authors.lastname: Traore
authors.forename: Bocar
authors.initials: B
authors.lastname: Kouyate
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002050:Burkina Faso; D002675:Child, Preschool; D015331:Cohort Studies; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D018512:Parasitemia / Q000175:diagnosis / Q000188:drug therapy; D011739:Pyrimethamine / Q000627:therapeutic use*; D013413:Sulfadoxine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine