Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia.
OBJECTIVE
To report a case of conjunctival-corneal intraepithelial neoplasia (CCIN) in an elderly African American patient treated with topical mitomycin C and the subsequent complication of limbal stem cell deficiency.


METHODS
Interventional case report.


METHODS
A 92-year-old African American woman was diagnosed with CCIN in the right eye. Following incisional biopsy, the patient received five 1-week courses of 0.04% mitomycin C and was followed over a period of 10 months.


RESULTS
The CCIN regressed completely following mitomycin C therapy. Three months later, the patient developed recurrent nonhealing epithelial defects in the right cornea.


CONCLUSIONS
Conjunctival-corneal intraepithelial neoplasia may occur in the African American population. Although MMC is effective in eradicating CCIN, a limbal stem cell deficiency may complicate the treatment.
Dudney
Blonie W
BW
Department of Ophthalmology, University of Tennessee Health Science Center, College of Medicine, 956 Court Avenue, D228, Memphis, TN 38163, USA.
Malecha
Monika A
MA
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003316:Corneal Diseases / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D019573:Epithelium, Corneal / Q000187:drug effects* / Q000473:pathology; D005134:Eye Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D006801:Humans; D016850:Limbus Corneae / Q000187:drug effects / Q000473:pathology; D016685:Mitomycin / Q000009:adverse effects*; D012008:Recurrence; D013234:Stem Cells / Q000187:drug effects* / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin