Asymmetric Michael reaction promoted by new chiral phase-transfer catalysts.
A catalytic asymmetric Michael reaction promoted by new chiral quaternary ammonium salts is described. The products are obtained with moderate ee (up to 75% ee), and the enantioselectivity is strongly dependent on both the substituents on the aromatic rings and the ammonium moiety in the catalysts.
Arai
Shigeru
S
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan. arai@p.chiba-u.ac.jp
Tokumaru
Kazuyuki
K
Aoyama
Toyohiko
T
D002384:Catalysis; D044367:Phase Transition; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000378:metabolism*; D013237:Stereoisomerism
D000644:Quaternary Ammonium Compounds