title: [Structure of the gene pool of eastern Ukrainians from Y-chromosome haplogroups].
abstract: Y chromosomes from representative sample of Eastern Ukrainians (94 individuals) were analyzed for composition and frequencies of haplogroups, defined by 11 biallelic loci located in non-recombining part of the chromosome (SRY1532, YAP, 92R7, DYF155S2, 12f2, Tat, M9, M17, M25, M89, and M56). In the Ukrainian gene, pool six haplogroups were revealed: E, F (including G and I), J, N3, P, and R1a1. These haplogroups were earlier detected in a study of Y-chromosome diversity on the territory of Europe as a whole. The major haplogroup in the Ukrainian gene pool, haplogroup R1a1 (earlier designated HG3), accounted for about 44% of all Y chromosomes in the sample examined. This haplogroup is thought to mark the migration patterns of the early Indo-Europeans and is associated with the distribution of the Kurgan archaeological culture. The second major haplogroup is haplogroup F (21.3%), which is a combination of the lineages differing by the time of appearance. Haplogroup P found with the frequency of 9.6%, represents the genetic contribution of the population originating from the ancient autochthonous population of Europe. Haplogroups J and E (11.7 and 4.2%, respectively) mark the migration patterns of the Middle-Eastern agriculturists during the Neolithic. The presence of the N3 lineage (9.6%) is likely explained by a contribution of the assimilated Finno-Ugric tribes. The data on the composition and frequencies of Y-chromosome haplogroups in the sample studied substantially supplement the existing picture of the male lineage distribution in the Eastern Slav population.
authors.affiliation: Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, 634050 Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Khar'kov
authors.forename: V A
authors.initials: VA
authors.lastname: Stepanov
authors.forename: S A
authors.initials: SA
authors.lastname: Borinskaia
authors.forename: Zh M
authors.initials: ZhM
authors.lastname: Kozhekbaeva
authors.forename: V A
authors.initials: VA
authors.lastname: Gusar
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Grechanina
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
authors.forename: N K
authors.initials: NK
authors.lastname: Iankovskiĭ
mesh_terms: D001483:Base Sequence; D041322:Chromosomes, Human, Y; D017931:DNA Primers; D005788:Gene Pool; D006239:Haplotypes; D006801:Humans; D014455:Ukraine
chemical_list: D017931:DNA Primers