Complete response of multiple melanoma brain metastases after treatment with temozolomide.
BACKGROUND
Inoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare.


METHODS
A patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance.


CONCLUSIONS
The present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.
Dvorak
J
J
Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic. dvorakj@fnhk.cz
Melichar
B
B
Zizka
J
J
Hadzi-Nikolov
D
D
Petera
J
J
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D012074:Remission Induction; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D000077204:Temozolomide; D016896:Treatment Outcome
D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide