[Expression of leukocytic adhesion molecules in a patient with common variable immunodeficiency].
BACKGROUND
Common variable immunodeficiency is one of the main antibodies' deficiency syndromes.


OBJECTIVE
To present the immunological study of a 29-year-old patient with common variable immunodeficiency who assisted to a check-up after being four years without treatment with gammaglobuline.


METHODS
We studied a sample of peripheral blood and saliva of a patient with common variable immunodeficiency and that of a healthy patient (control). Assessment of immunoglobulin G, immunoglobulin A and immunoglobuin M was performed by a simple radial immunodiffusion test, and immunoglobulin E by immunoassay. Immunophenotypic study of leukocytic subpopulations was done by citometry by using the following panel of monoclonal antibodies: CD3 (Leu-4), CD4 (Leu-3a), CD8 (Leu-2a), CD19 (Leu-12), CD14 (Leu-M3), CD11a (LFA-I), CD49d (VLA-4), CD54 (ICAM-1), CD31 (PECAM).


RESULTS
It was found a significant reduction in most of the serum and secretory immunoglobulins, levels of unusual expression of integrines CD11a and CD31 in lymphocytes T related to the low percentage of activated lymphocytes T/memory.
Menso
Emilia
E
Hospital Nacional de Clínicas, Facultad de Medicina, Universidad Nacional de Córdoba, Argentina.
Alberto Romagnoli
Pablo
P
Teresa Criscuolo
María
M
Federico Barcelona
Pablo
P
Gerardo Collino
César Juan
CJ
Marcelo Serra
Horacio
H
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001769:Blood / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000276:immunology; D017074:Common Variable Immunodeficiency / Q000276:immunology* / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D016130:Immunophenotyping; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets; D008297:Male; D012463:Saliva / Q000276:immunology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins