Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.
We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with controls (OR=0.19, p(corr)<.05), implying a possible protective effect against development of the disease. There was also a trend toward increased MnSODAla allele and phenotype frequencies in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphisms in healthy Africans and further evidence that genetic factors may have a contributory role to play in predisposing to oxidative stress in SSc.
Tikly
Mohammed
M
Department of Medicine, Chris Hani Baragwanath Hospital, and the University of the Witwatersrand, Johannesburg, South Africa. tiklym@medicine.wits.ac.za
Marshall
Sara E
SE
Haldar
Neil A
NA
Gulumian
Mary
M
Wordsworth
Paul
P
Welsh
Ken I
KI
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012595:Scleroderma, Systemic / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000235:genetics*
D016166:Free Radical Scavengers; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D010100:Oxygen