title: [Yixintong tablet's protection against experimental myocardial ischemia].
abstract: OBJECTIVE
  Various models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia.
  
  
  METHODS
  Models of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline) to check the indices of ECG, hemodynamics, and morphology.
  
  
  RESULTS
  A dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty-minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Yixintong tablets exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (+/- dp/dtmax), and ST segment (electrocardiogram). The tablet markedly reduced the myocardial infarct size of the coronary-ligatured rats. The tablet benefited the rats with pituitrin(iv)- or isoprenaline(ip)-induced acute myocardial ischemia to reverse any ST deviation and T-wave fall.
  
  
  CONCLUSIONS
  Yixintong has a protective and therapeutic action to the experimental myocardial ischemia.
authors.affiliation: Pharmacology Department, Shanxi Institute for Drug Control, Taiyuan 030001, Shanxi, China. Mary paio@263.net
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Piao
authors.forename: Pei-zhi
authors.initials: PZ
authors.lastname: Tong
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Tian-hong
authors.initials: TH
authors.lastname: Gao
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiang-hua
authors.initials: XH
authors.lastname: Lu
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D027825:Crataegus / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D017202:Myocardial Ischemia / Q000473:pathology / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013607:Tablets
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D013607:Tablets