The kinetic model and simulation of blood coagulation--the kinetic influence of activated protein C.
The paper described a limited part of the coagulation pathway, and in particular the inhibitory effects of activated protein C in the context of thrombin production. This is a computational modeling study with various assumption made of kinetic rates laws and their summation. The level of complexity and assumed parameters makes conclusions uncertain. However, an interesting outcome is that kinetic reaction rates may show oscillation behavior under particular, high levels of protein C feedback inhibition. The model would defy quantitative practical use, but could have predictive value as a qualitative descriptor of coagulation.
Qiao
Y H
YH
Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing 100022, China.
Xu
C Q
CQ
Zeng
Y J
YJ
Xu
X H
XH
Zhao
H
H
Xu
H
H
D001683:Biological Clocks; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D003198:Computer Simulation; D004789:Enzyme Activation; D005246:Feedback / Q000502:physiology; D006487:Hemostasis / Q000502:physiology; D007700:Kinetics; D008955:Models, Cardiovascular; D011493:Protein Kinase C / Q000378:metabolism*; D013917:Thrombin / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood / Q000503:physiopathology
D001779:Blood Coagulation Factors; D011493:Protein Kinase C; D013917:Thrombin