Coexistence of BCL1/CCND1 and CMYC aberrations in blastoid mantle cell lymphoma: a rare finding associated with very poor outcome.
A patient with mantle cell lymphoma (MCL) of the pleomorphic blastoid subtype is reported. The disease was clinically aggressive and refractory to chemotherapy, and the patient survived only 2 months. Cytogenetically, a t(11;19;14)(q13;q13;q32) was found. Fluorescent in situ hybridization (FISH) and molecular analyses demonstrated involvement of the BCL1/CCND1 locus in a three-way translocation. In addition, subclonal abnormalities of the region 8q24 manifested either as a t(8;22)(q24;q11)/CMYC rearrangement or trisomy 8 were identified. The pathogenetic impact of this very uncommon association of BCL1/CCND1 and CMYC rearrangements in MCL is discussed and the literature is reviewed.
Michaux
L
L
Department of Hematology, Clinical Biology and Pathology, Cliniques universitaires UCL St Luc, Brussels, Belgium.
Wlodarska
I
I
Theate
I
I
Stul
M
M
Scheiff
J-M
JM
Deneys
V
V
Ferrant
A
A
Hagemeijer
A
A
D000368:Aged; D002877:Chromosomes, Human / Q000235:genetics; D019938:Cyclin D1 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D020522:Lymphoma, Mantle-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*; D016896:Treatment Outcome; D014314:Trisomy / Q000235:genetics*
D004273:DNA, Neoplasm; D016271:Proto-Oncogene Proteins c-myc; D019938:Cyclin D1