title: C-kit receptor expression in acute leukemias-association with patient and disease characteristics and with outcome.
abstract: We hypothesize that c-kit expression may be associated with disease-specific features and have prognostic value in acute leukemias. In acute lymphocytic leukemia (ALL), higher levels of c-kit expression predicted lower complete response (CR) rates, suggesting that these patients may benefit from acute myelogenous leukemia (AML) therapy. Despite a negative association with the Philadelphia-chromosome, there was no correlation with disease-free survival (DFS) in CR. In AML, c-kit was associated with older age and cytogenetic abnormality t(-5, -7). Consequently higher levels of c-kit predicted lower CR rates. However, after accounting for these covariates, multivariate analysis indicates that higher c-kit expression predicts higher CR rates, although there was no effect on DFS in CR.
authors.affiliation: MD Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, P.O. Box 428 Houston, TX 77030, USA.
authors.forename: Anne S
authors.initials: AS
authors.lastname: Tsao
authors.forename: Hagop
authors.initials: H
authors.lastname: Kantarjian
authors.forename: Deborah
authors.initials: D
authors.lastname: Thomas
authors.forename: Francis
authors.initials: F
authors.lastname: Giles
authors.forename: Jorge
authors.initials: J
authors.lastname: Cortes
authors.forename: Guillermo
authors.initials: G
authors.lastname: Garcia-Manero
authors.forename: Yang
authors.initials: Y
authors.lastname: Huh
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Maher
authors.initials: M
authors.lastname: Albitar
authors.forename: Elihu
authors.initials: E
authors.lastname: Estey
mesh_terms: D000328:Adult; D000367:Age Factors; D018952:Antigens, CD34 / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000032:analysis*; D018826:CD13 Antigens / Q000096:biosynthesis; D018572:Disease-Free Survival; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit; D018826:CD13 Antigens