A porcine epistaxis model: hemostatic effects of octylcyanoacrylate.
OBJECTIVE
To develop a standardized porcine epistaxis model and evaluate the hemostatic effects of octyl-cyanoacrylate (OCA).


METHODS
Twenty-four standardized full-thickness wounds were created on the nasal septae of 7 pigs with a 4-mm surgical punch. Wounds were randomized to no treatment or topical OCA before and after full heparinization. The rate of hemostasis, time to hemostasis, and number of applicators of OCA required to achieve complete hemostasis were determined and groups were compared with t tests and chi2 tests.


RESULTS
Complete and sustained hemostasis was achieved in all wounds treated with OCA. The time to hemostasis was significantly shorter in the wounds treated with OCA vs those left to clot on their own (mean difference, 150 seconds; 95% CI, 92 to 209 seconds, P<0.001). None of the wounds required more than 3 applications of OCA.


CONCLUSIONS
We describe a simple and reproducible animal epistaxis model and demonstrate that OCA is effective in achieving hemostasis in this model.
Singer
Adam J
AJ
Department of Emergency Medicine, University Medical Center, Stony Brook, New York 11794-7400, USA. Adam.Singer@stonybrook.edu
McClain
Steve A
SA
Katz
Arnold
A
D000287:Administration, Topical; D000818:Animals; D003487:Cyanoacrylates / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004844:Epistaxis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006490:Hemostatics / Q000008:administration & dosage / Q000627:therapeutic use*; D008137:Longitudinal Studies; D009297:Nasal Mucosa / Q000293:injuries; D015203:Reproducibility of Results; D013552:Swine; D013997:Time Factors
D003487:Cyanoacrylates; D006490:Hemostatics; C119247:octylcyanoacrylate