Comparative analysis between dextran sulfate adsorption and direct adsorption of lipoproteins in their capability to reduce erythrocyte adhesiveness/aggregation in the peripheral blood.
The purpose of this study was to compare the degree of erythrocyte adhesiveness/aggregation (EAA) reduction of two low-density lipoprotein (LDL) apheretic procedures, namely direct adsorption of lipoproteins (DALI) and dextran sulfate adsorption (DSA). A significant (P < 0.001) reduction of EAA was noted in six hypercholesterolemic patients who underwent a total of 40 apheretic sessions and no difference was noted in the degree of EAA reduction by the two techniques. Thus. being a real-time and point-of-care test, the erythrocyte adhesiveness/aggregation test can be applied in relevant situations of acute ischemia, where therapeutic LDL apheresis could improve the hemorheology of individuals with increased concentrations of cholesterol and inflammatory sensitive proteins.
Schechner
V
V
Department of Internal Medicine A and the Lipid Unit, Rabin Medical Center Campus Beilinson, all affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Berliner
S
S
Shapira
I
I
Justo
D
D
Hershcovici
T
T
Zeltser
D
D
Beigel
Y
Y
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000737:chemistry / Q000627:therapeutic use*; D001781:Blood Component Removal; D016264:Dextran Sulfate / Q000737:chemistry / Q000627:therapeutic use*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy*; D008074:Lipoproteins / Q000097:blood* / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000925:Anticoagulants; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D016264:Dextran Sulfate