Effect of postmolding heat treatment on in vitro properties of a polyanhydride implant containing gentamicin sulfate.
A polyanhydride implant containing gentamicin sulfate was fabricated using a laboratory-scale injection-molding machine. After injection molding, the implants were subject to heat treatment at 60 degrees C for various time periods with or without nitrogen protection. The impact of this heat treatment on the in vitro properties of the implants including copolymer molecular weights, mechanical properties, and in vitro drug-release profiles was investigated. This heat treatment caused a drastic drop in the molecular weight of the copolymer. Heating without nitrogen protection resulted in the hardening of the implant, but heating in the presence of nitrogen rendered the implant less rigid. It was also found that a faster in vitro drug release profile was shown by implants heated without nitrogen protection and a pronounced slowing down in drug release was exhibited by implants heated with nitrogen protection.
Deng
J
J
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA. dengjs@hpd.abbott.com
Li
L
L
Stephens
D
D
Tian
Y
Y
Robinson
D
D
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids; D004343:Drug Implants; D004883:Erucic Acids / Q000737:chemistry*; D005839:Gentamicins / Q000737:chemistry*; D006358:Hot Temperature; D008970:Molecular Weight; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical
D000900:Anti-Bacterial Agents; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D004343:Drug Implants; D004883:Erucic Acids; D005839:Gentamicins; D011108:Polymers; C049811:erucic acid; C011107:sebacic acid