title: Multislice first-pass myocardial perfusion imaging: Comparison of saturation recovery (SR)-TrueFISP-two-dimensional (2D) and SR-TurboFLASH-2D pulse sequences.
abstract: OBJECTIVE
  To compare signal-to-noise ratio (SNR), contrast-to-noise (CNR) ratio, and diagnostic accuracy of a newly developed saturation recovery (SR)-TrueFISP-two-dimensional (2D) sequence with an SR-TurboFLASH-2D sequence.
  
  
  METHODS
  In seven healthy subjects and nine patients with coronary artery disease (CAD), contrast-enhanced perfusion imaging (with Gd-DTPA) was performed with SR-TrueFISP and SR-TurboFLASH sequences. Hypoperfused areas were assessed qualitatively (scale = 0-4). Furthermore, SNR and CNR were calculated and semiquantitative perfusion parameters were determined from signal intensity (SI) time curves. Standard of reference for patient studies was single-photon emission computer tomography (SPECT) and angiography.
  
  
  RESULTS
  The perception of perfusion deficits was superior in TrueFISP images (2.6 +/- 1.0) than in TurboFLASH (1.4 +/- 0.6) (P < 0.001). Phantom measurements yielded increased SNR (143 +/- 34%) and CNR (158 +/- 64%) values for TrueFISP. In patient/volunteer studies SNR was 61% to 100% higher and signal enhancement was 110% to 115% higher with TrueFISP than with TurboFLASH. Qualitative and semiquantitative assessment of perfusion defects yielded higher sensitivities for detection of perfusion defects with TrueFISP (68% to 78%) than with TurboFLASH (44% to 59%).
  
  
  CONCLUSIONS
  SR-TrueFISP-2D perfusion imaging provides superior SNR and CNR than TurboFLASH imaging. Moreover, the dynamic range of SIs was found to be higher with TrueFISP, resulting in an increased sensitivity for detection of perfusion defects.
authors.affiliation: Department of Diagnostic Radiology, Eberhard-Karls-University, Tuebingen, Germany. michael.fenchl@med.uni-tuebingen.de
authors.forename: Michael
authors.initials: M
authors.lastname: Fenchel
authors.forename: Uwe
authors.initials: U
authors.lastname: Helber
authors.forename: Orlando P
authors.initials: OP
authors.lastname: Simonetti
authors.forename: Norbert I
authors.initials: NI
authors.lastname: Stauder
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kramer
authors.forename: Co-Nghi
authors.initials: CN
authors.lastname: Nguyen
authors.forename: J Paul
authors.initials: JP
authors.lastname: Finn
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Stephan
authors.initials: S
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003326:Coronary Circulation; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D012016:Reference Values; D012680:Sensitivity and Specificity