title: Skin reactions due to low molecular weight heparin in pregnancy: a strategic dilemma.
abstract: BACKGROUND
  Heparin-induced allergic reactions may cause problems if heparin administration is needed for thrombo-embolic disease in pregnancy.
  
  
  METHODS
  We report two cases of hypersensitivity to low molecular weight heparin (LMWH) in pregnancy.
  
  
  CONCLUSIONS
  Alternative methods and new antithrombotic agents are discussed.
authors.affiliation: Department of Obstetrics and Gynaecology, Academic Medical Centre H4-249, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. a.e.verdonkschot@amc.uva.nl
authors.forename: A E M
authors.initials: AE
authors.lastname: Verdonkschot
authors.forename: W L E
authors.initials: WL
authors.lastname: Vasmel
authors.forename: S
authors.initials: S
authors.lastname: Middeldorp
authors.forename: J T M
authors.initials: JT
authors.lastname: van der Schoot
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology*; D005165:Factor V / Q000235:genetics; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D011247:Pregnancy; D011655:Pulmonary Embolism / Q000517:prevention & control; D020246:Venous Thrombosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight; C095381:factor V Leiden; D005165:Factor V