title: A comparative study of myo-inositol quantification using LCmodel at 1.5 T and 3.0 T with 3 D 1H proton spectroscopic imaging of the human brain.
abstract: Myo-inositol is a strongly coupled system and resonates at four chemical shift positions. At 1.5 T, only the singlet component at 3.57 ppm is detected. However, at 3 T this resonance is resolved into its components at 3.55 ppm and 3.61 ppm. Due to the increased spectral resolution and signal-to-noise ratio, it is anticipated that the quantification of myo-inositol should improve at 3 T. Using data from normal controls and the LCmodel quantification procedure, we found that the quantification precision, reproducibility and detection sensitivity of myo-inositol is significantly better at 3 T relative to 1.5 T.
authors.affiliation: Magnetic Resonance Science Center, University of California, AC109, Box 1290, San Francisco, CA 94143, USA. rsriniva@mrsc.ucsf.edu
authors.forename: Radhika
authors.initials: R
authors.lastname: Srinivasan
authors.forename: Daniel
authors.initials: D
authors.lastname: Vigneron
authors.forename: Napapon
authors.initials: N
authors.lastname: Sailasuta
authors.forename: Ralph
authors.initials: R
authors.lastname: Hurd
authors.forename: Sarah
authors.initials: S
authors.lastname: Nelson
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004151:Dipeptides / Q000378:metabolism; D005260:Female; D006801:Humans; D006859:Hydrogen; D007294:Inositol; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D019047:Phantoms, Imaging; D011522:Protons; D012016:Reference Values; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
chemical_list: D004151:Dipeptides; D011522:Protons; C027172:isospaglumic acid; D001224:Aspartic Acid; D007294:Inositol; D006859:Hydrogen; C000179:N-acetylaspartate