Identification of a new HLA-Cw*05 allele, HLA-Cw*0505*.
We have identified a new human leukocyte antigen-C allele in a Caucasian potential stem-cell donor. The new allele is identical to the other Cw*05 alleles in exon 2 but differs from Cw*0501 and *0503 at nucleotide position 379 in exon 3, where a C is substituted with a G. This results in an amino acid substitution from leucine to valine at residue 103 in alpha2 helix.
Bengtsson
M
M
Section of Clinical Immunology, Department of Oncology, Radiology and Clinical Immunology, Rudbeck Laboratory, University Hospital, Uppsala, Sweden. mats.bengtsson@klinimm.uu.se
Danielsson
F
F
Jansson
I E
IE
Senkas
A
A
D001483:Base Sequence; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
D015236:HLA-C Antigens; C495077:HLA-C*05:05 antigen