Highly enantioselective catalytic carbon dioxide incorporation reaction: nickel-catalyzed asymmetric carboxylative cyclization of bis-1,3-dienes.
A method for nickel-catalyzed asymmetric carbon dioxide (CO2) incorporation via carbon-carbon bond formation was developed. In the presence of a catalytic amount of Ni(acac)2 and MeO-MOP, various bis-1,3-dienes reacted with CO2 (1 atm) and a diorganozinc reagent (Me2Zn or Ph2Zn) to afford cyclic carboxylic acids in good yields (71-100%) and with high enantioselectivities (90-96% ee).
Takimoto
Masanori
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido, Sapporo 060-0812, Japan.
Nakamura
Yoichi
Y
Kimura
Kaoru
K
Mori
Miwako
M