title: Moderately nonlinear ultrasound propagation in blood-mimicking fluid.
abstract: In medical diagnostic ultrasound (US), higher than-in-water nonlinearity of body fluids and tissue usually does not produce strong nonlinearly distorted waves because of the high absorption. The relative influence of absorption and nonlinearity can be characterized by the Gol'dberg number Gamma. There are two limiting cases in nonlinear acoustics: weak waves (Gamma < 1) or strong waves (Gamma >> 1). However, at diagnostic frequencies in tissue and body fluids, the nonlinear effects and effects of absorption more likely are comparable (Gol'dberg number Gamma approximately 1). The aim of this work was to study the nonlinear propagation of a moderately nonlinear US second harmonic signal in a blood-mimicking fluid. Quasilinear solutions to the KZK equation are presented, assuming radiation from a flat and geometrically focused circular Gaussian source. The solutions are expressed in a new simplified closed form and are in very good agreement with those of previous studies measuring and modeling Gaussian beams. The solutions also show good agreement with the measurements of the beams produced by commercially available transducers, even without special Gaussian shading.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Kharin
authors.forename: D Geoffrey
authors.initials: DG
authors.lastname: Vince
mesh_terms: D000042:Absorption; D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D001769:Blood / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D005990:Glycerol; D006801:Humans; D008954:Models, Biological; D017711:Nonlinear Dynamics; D016011:Normal Distribution; D014159:Transducers; D014465:Ultrasonics; D014463:Ultrasonography
chemical_list: D005990:Glycerol