Influence of PAMAM dendrimers on human red blood cells.
Polyamidoamine (PAMAM) dendrimers with different concentrations (1 nM-1 mM) (generations 2, 3, and 4) impact on human red blood cell morphology, and membrane integrity is studied. Erythrocyte shape changes from biconcave to echinocytic in dendrimers. Cell aggregation occurs. Polymers cause also concentration- and generation-dependent haemolysis.
Domański
D M
DM
Department of General Biophysics, Institute of Biophysics, University of Łódź, 12/16 Banacha Street, Łódź 90-237, Poland.
Klajnert
B
B
Bryszewska
M
M
D048429:Cell Size / Q000187:drug effects*; D002478:Cells, Cultured; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000502:physiology; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D011073:Polyamines / Q000145:classification / Q000494:pharmacology*; D011108:Polymers / Q000494:pharmacology
D011073:Polyamines; D011108:Polymers