title: Improving liver allocation: MELD and PELD.
abstract: On February 27, 2002, the liver allocation system changed from a status-based algorithm to one using a continuous MELD/PELD severity score to prioritize patients on the waiting list. Using data from the Scientific Registry of Transplant Recipients, we examine and discuss several aspects of the new allocation, including the development and evolution of MELD and PELD, the relationship between the two scoring systems, and the resulting effect on access to transplantation and waiting list mortality. Additional considerations, such as regional differences in MELD/PELD at transplantation and the predictive effects of rapidly changing MELD/PELD, are also addressed. Death or removal from the waiting list for being too sick for a transplant has decreased in the MELD/PELD era for both children and adults. Children younger than 2 years, however, still have a considerably higher rate of death on the waiting list than adults. A limited definition of ECD livers suggests that they are used more frequently for patients with lower MELD scores.
authors.affiliation: Tufts-New England Medical Center, Boston, MA, USA. rfreeman@tufts-nemc.org
authors.forename: Richard B
authors.initials: RB
authors.lastname: Freeman
authors.forename: Russell H
authors.initials: RH
authors.lastname: Wiesner
authors.forename: John P
authors.initials: JP
authors.lastname: Roberts
authors.forename: Suzanne
authors.initials: S
authors.lastname: McDiarmid
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Dykstra
authors.forename: Robert M
authors.initials: RM
authors.lastname: Merion
mesh_terms: D000328:Adult; D017677:Age Distribution; D002648:Child; D015276:Health Care Rationing / Q000379:methods*; D006801:Humans; D017093:Liver Failure / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D009927:Tissue and Organ Procurement / Q000458:organization & administration*; D016896:Treatment Outcome; D014481:United States; D014850:Waiting Lists