New probes for microtubule dynamics.
A phenotype-based screen identifies a purine analog, named diminutol, that perturbs the microtubule cytoskeleton in cells. An affinity-based approach identifies a protein target of this small molecule and leads to the characterization of a new pathway that may regulate cytoskeleton dynamics.
Peters
Ulf
U
Rockefeller University, New York, NY 10021, USA.
Kapoor
Tarun M
TM
D000818:Animals; D001704:Biopolymers; D006801:Humans; D008870:Microtubules / Q000502:physiology*; D015335:Molecular Probes / Q000378:metabolism; D011687:Purines / Q000494:pharmacology*; D013440:Sulfides / Q000494:pharmacology*; D014404:Tubulin / Q000502:physiology*
D001704:Biopolymers; D015335:Molecular Probes; D011687:Purines; D013440:Sulfides; D014404:Tubulin; C491035:diminutol