Efficacy of platelet-rich plasma in alveolar bone grafting.
OBJECTIVE
In this study, we performed alveolar bone grafting with autologous iliac cancellous bone incorporation with platelet-rich plasma (PRP) and evaluated its efficacy in osteoregeneration.


METHODS
Seven alveolar cleft patients with adult dentition (average age, 16.1 years) underwent iliac bone grafting with PRP. Quantitative evaluation of regenerated bone was made with 3-dimensional computed tomography scans and compared with controls.


RESULTS
The average of the volume ratio of regenerated bone to alveolar cleft in cases with PRP was higher than in controls (P <.05). There were no complications from the blood draw or PRP.


CONCLUSIONS
PRP was a safe and cost-effective source for growth factors and was easy to extract. It could enhance the osteogenesis of alveolar bone grafting in cleft lip and palate patients and may useful for subsequent orthodontic therapy.
Oyama
Tomoki
T
Department of Plastic Surgery, Kobe Children's Hospital, Japan. Tomoki.Oyama@mb2.seikyou.ne.jp
Nishimoto
Soh
S
Tsugawa
Tomoe
T
Shimizu
Fumiaki
F
D000293:Adolescent; D000539:Alveolar Process / Q000002:abnormalities; D000543:Alveoloplasty / Q000379:methods*; D001792:Blood Platelets / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D002971:Cleft Lip / Q000150:complications; D002972:Cleft Palate / Q000601:surgery; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D017713:Platelet Transfusion; D014014:Tissue Adhesives / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives