Comparison of histidine-tryptophan-ketoglutarate solution and University of Wisconsin solution for organ preservation in clinical pancreas transplantation.
BACKGROUND
University of Wisconsin (UW) solution is currently the standard preservation solution used for abdominal organ transplantation. This study assesses the efficacy of histidine-tryptophan-ketoglutarate (HTK) compared with UW in pancreas transplantation.


METHODS
Between October 2002 and August 2003, 20 pancreas transplants were performed. Patients were divided into two groups: UW (n=10) and HTK (n=10). Donor and recipient demographics were similar in both groups. The mean cold ischemia time for both groups was 11 +/-3 hr.


RESULTS
There was an anticipated difference between total preservative volumes used (HTK: 4.5 +/- 1.2 L vs. UW: 3.4 +/-0.8 L; P =0.03). Patient and graft survivals to date were 100% in both groups. Serum fasting blood glucose, peak amylase, and serial amylase levels remained comparable at all intervals posttransplantation.


CONCLUSIONS
Within this range of cold ischemia time, UW and HTK demonstrate similar efficacy in pancreas preservation.
Fridell
Jonathan A
JA
Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. jfridell@iupui.edu
Agarwal
Avinash
A
Milgrom
Martin L
ML
Goggins
William C
WC
Murdock
Philip
P
Pescovitz
Mark D
MD
D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005947:Glucose; D005978:Glutathione; D006085:Graft Survival; D006801:Humans; D007328:Insulin; D008297:Male; D008353:Mannitol; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D010179:Pancreas; D016035:Pancreas Transplantation / Q000502:physiology; D011189:Potassium Chloride; D011343:Procaine; D011887:Raffinose
D001786:Blood Glucose; C039984:Bretschneider cardioplegic solution; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D011343:Procaine; D000493:Allopurinol; D011189:Potassium Chloride; D005978:Glutathione; D005947:Glucose; D000241:Adenosine; D011887:Raffinose