Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccines.
The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared. Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12 and 24, and the anti-HAV total IgG antibody and IgG subclass profile were assessed. In both vaccinated groups, the geometric mean titer (GMT) of anti-HAV peaked 7 months after the initial dose and declined during the following months. The IgG subclass profiles in both vaccinated groups were highly restricted to IgG1 and IgG3. Both vaccines have been shown highly effective in preventing viral hepatitis A in former studies.
Wang
Xuan-Yi
XY
Department of Medical Molecular Virology, 138 Yi Xue Yuan Road, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Xu
Zhiyi
Z
Yao
Xing
X
Tian
Meiying
M
Zhou
Liangdi
L
He
Lifang
L
Wen
Yumei
Y
D002648:Child; D002675:Child, Preschool; D005260:Female; D035922:Hepatitis A Antibodies / Q000032:analysis / Q000096:biosynthesis*; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D014613:Vaccines, Attenuated / Q000276:immunology; D015164:Vaccines, Inactivated / Q000276:immunology
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D007074:Immunoglobulin G; D014613:Vaccines, Attenuated; D015164:Vaccines, Inactivated