title: Transfusion-associated HIV infection in Mexico related to paid blood donors; HIV epidemic.
abstract: The objective of the study was to describe the clinical, epidemiological profile and conditional incubation period in a group of transfusion-associated HIV-infected (TAHI) patients seen in five national tertiary care centres in Mexico from 1983 to April 1998. Date of transfusions, AIDS diagnoses, opportunistic infections and malignancies were collected. The incubation period was estimated through a non-parametric conditional analysis. One hundred and fifty-seven TAHI cases were analysed. The frequency of TAHI by year of transfusion was: 0.6% in 1980 and 1981, 4.5% in 1984, 22.4% in 1985, 54.5% in 1986, 10.3% in 1987, 0.6% in 1988, 1.9% in 1989 and 1990, 1.3% in 1993 and 0.6% in 1994 and 1996. The median incubation period was 4.3 years. A well-defined epidemic period of HIV-infection among blood-recipients was identified that coincided with the HIV-epidemic among paid donors. TAHI patients in Mexico developed AIDS in a shorter time than that described for other populations.
authors.affiliation: Instituto Nacional de Cancerología, Departamento de Enfermedades Infecciosas, Av. San Fernando #22, México DF CP 14080. volkow@infosel.net.mx
authors.forename: Patricia
authors.initials: P
authors.lastname: Volkow
authors.forename: Silvia Ruiz
authors.initials: SR
authors.lastname: Velasco
authors.forename: Nancy
authors.initials: N
authors.lastname: Mueller
authors.forename: Samuel
authors.initials: S
authors.lastname: Ponce de Leon
authors.forename: Juan Gerardo
authors.initials: JG
authors.lastname: Sierra-Madero
authors.forename: Eduardo
authors.initials: E
authors.lastname: Sada
authors.forename: José Luis
authors.initials: JL
authors.lastname: Soto
authors.forename: Franz
authors.initials: F
authors.lastname: Perez-Ancona
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ruiz-Palacios
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Castillo
authors.forename: Alejandro
authors.initials: A
authors.lastname: Mohar
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000635:transmission; D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D002648:Child; D002675:Child, Preschool; D019992:Databases as Topic; D004196:Disease Outbreaks; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D013997:Time Factors; D065227:Transfusion Reaction