Novel function of PS2V: change in conformation of tau proteins.
Neurofibrillary tangles (NFTs) are associated with many neurodegenerative disorders, such as Alzheimer's disease (AD). The major components of NFTs are hyper-phosphorylated tau proteins. The alternatively spliced form of the presenilin-2 (PS2) gene (PS2V) has been observed in sporadic AD brains. However, it is not known whether there is a relationship between tau aggregation/hyper-phosphorylation and PS2V expression. In this manuscript, we make the first report of PS2V alterations in the conformation of the tau protein (unknown form of tau) in the human neuroblastoma cell line.
Nishikawa
Atsuko
A
Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan.
Manabe
Takayuki
T
Katayama
Taiichi
T
Kudo
Takashi
T
Matsuzaki
Shinsuke
S
Yanagita
Takeshi
T
Okuda
Hiroaki
H
Bando
Yoshio
Y
Tohyama
Masaya
M
D045744:Cell Line, Tumor; D015870:Gene Expression; D006801:Humans; D015151:Immunoblotting; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D009447:Neuroblastoma / Q000378:metabolism; D010766:Phosphorylation; D053766:Presenilin-2; D011487:Protein Conformation; D014415:Tunicamycin / Q000494:pharmacology; D016875:tau Proteins / Q000737:chemistry* / Q000378:metabolism
D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; D016875:tau Proteins; D014415:Tunicamycin