No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia.
Mutations in the GATA-1 gene have been identified in patients with familial macrothrombocytopenia and Down's syndrome patients with a transient myeloproliferative disorder and/or acute megakaryoblastic leukemia. We screened this gene in 46 patients with essential thrombocythemia and identified only a common single nucleotide polymorphism that is unlikely to be of pathological significance.
Gandini
Domenica
D
Allen
Anthony J R
AJ
Nash
Michael J
MJ
Linch
David C
DC
Gale
Rosemary E
RE
D000818:Animals; D005260:Female; D050982:GATA1 Transcription Factor / Q000235:genetics*; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013920:Thrombocythemia, Essential / Q000235:genetics*
D050982:GATA1 Transcription Factor