Effects of marine beta-1,3 glucan on immune reactions.
Glucans have a long history as nonspecific biological modulators. A novel glucan-Phycarine-was isolated from sporophytes of Laminaria digitata. Phycarine showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-1, IL-6 and TNF-alpha. In addition, Phycarine increased NK cell-mediated killing of tumor cells both in vitro and in vivo while acting via complement receptor type 3 (CR3) receptors.
Vetvicka
Vaclav
V
Department of Pathology and Laboratory Medicine, University of Louisville, 511 S. Floyd St., MDR Bldg., Rm. 224, Louisville, KY 40202, USA. vetvickavaclav@netscape.net
Yvin
Jean-Claude
JC
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D007155:Immunologic Factors / Q000494:pharmacology*; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects; D007912:Lentinan / Q000494:pharmacology; D016177:Macrophage-1 Antigen / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D047071:beta-Glucans / Q000494:pharmacology*
D015703:Antigens, CD; D000970:Antineoplastic Agents; D016207:Cytokines; D007155:Immunologic Factors; D016177:Macrophage-1 Antigen; D047071:beta-Glucans; D007912:Lentinan; C033363:beta-1,3-glucan