The IGF-I system component concentrations that decrease with ageing are lower in obesity in relationship to body mass index and body fat.
The aim of this study was to investigate the GH-IGF-I axis in healthy adults and its relationship to obesity. We studied 268 subjects: 134 men and 134 women, and determined anthropometric and body composition variables. Serum total IGF-I was measured by radioimmunoassay, serum free IGF-I concentrations by enzyme linked immunosorbant assay and serum IGFBP3 concentrations by radioimmunoassay. In men, we observed a decrease in total IGF-I, free IGF-I and IGFBP-3 throughout decades. In women, the body mass index and fat mass were higher throughout decades, and we observed a similar decrease to that in men in total IGF-I, free IGF-I and IGFBP3. In men with obesity, as measured by body fat, free IGF-I concentrations were lower than those without obesity; in women with obesity, total IGF-I concentrations and free IGF-I concentrations were lower than in those with obesity. These changes were observed in relationship to obesity when the subjects were adjusted for differences in age. We showed that in controls randomly selected, the GH-IGF-I axis component concentrations that decrease with increasing age are lower in obesity, especially in women, and that this decrease is related to body mass index and body fat.
Gómez
José Manuel
JM
Endocrinology Service, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Maravall
Francisco Javier
FJ
Gómez
Núria
N
Navarro
Miguel Angel
MA
Casamitjana
Roser
R
Soler
Juan
J
D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D001823:Body Composition; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity; D011863:Radioimmunoassay; D012737:Sex Factors
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I