HLA-B*1819, a novel HLA-B allele identified by sequence-based typing.
In this brief communication, we describe a novel human leukocyte antigen-B (HLA-B) allele (HLA-B*1819). This allele, found in an Italian Caucasian individual, differs from HLA-B*180101 by three nucleotide changes in exon 3. These mutations are located at positions 527, 538, and 539 where a T, a C, and a T are substituted respectively, by an A, a T, and a G, leading to three aminoacidic substitutions at codon 152 from Valine to Glutamic Acid (GTG-->GAG), at codon 155 from Histidine to Glutamine (CAC-->CAG), and at codon 156 from Cysteine to Tryptophan (TGT-->TGG).
Frison
S
S
Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milano, Italy.
Crespiatico
L
L
Longhi
E
E
Guizzardi
E
E
Poli
F
F
Scalamogna
M
M
D001483:Base Sequence; D015235:HLA-B Antigens / Q000235:genetics*; D059911:HLA-B18 Antigen; D006801:Humans; D008969:Molecular Sequence Data
D015235:HLA-B Antigens; C495071:HLA-B*18:19 antigen; D059911:HLA-B18 Antigen