title: [Selection of scaffolds of rat hepatocytes in three-dimension culture under simulated microgravity].
abstract: In order to investigate the biocompatibility, degradation and inflammatory reactions of poly benzyl glutamate (PBLG), poly lactic-co-glycolic acid (PLGA) and fibrin gel used as the scaffolds co-cultured with the hepatocytes of rats under simulated microgravity conditions in rotating wall vessel bioreactor (RWVB). PLGA is low biocompatibility, PBLG is medium biocompatibility with rat hepatocytes. Fibrin gel is high biocompatibility, no toxic degradation and no inflammatory reactions. Fibrin gel can be used as three dimensional scaffolds of rat hepatocytes under simulated microgravity.
authors.affiliation: College of Animal Science, South China Agricultural University, Guangzhou 510642.
authors.forename: Shou Quan
authors.initials: SQ
authors.lastname: Zhang
authors.forename: Shu Jing
authors.initials: SJ
authors.lastname: Gao
authors.forename: Qing Yan
authors.initials: QY
authors.lastname: Jiang
authors.forename: Quan Lin
authors.initials: QL
authors.lastname: Lao
authors.forename: Ding Yuan
authors.initials: DY
authors.lastname: Feng
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D019149:Bioreactors; D018929:Cell Culture Techniques; D005337:Fibrin / Q000737:chemistry*; D006016:Glycolates / Q000737:chemistry; D022781:Hepatocytes / Q000166:cytology*; D019344:Lactic Acid; D008422:Materials Testing; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017207:Rats, Sprague-Dawley; D018474:Weightlessness Simulation
chemical_list: D001672:Biocompatible Materials; D006016:Glycolates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005337:Fibrin