Differential effects of adrenergic and corticosteroid hormonal systems on human short- and long-term declarative memory for emotionally arousing material.
The effects of adrenergic and corticosteroid hormonal systems on emotional memory were measured in 64 young men. Placebo, propranolol (40 or 80 mg; beta blocker), or metyiapone (corticosteroid synthesis inhibitor) was administered before the viewing of a story composed of emotional and neutral segments. Short- and long-term declarative memory for the story was assessed. Propranolol 40 mg had no effects on declarative memory. Propranolol 80 mg impaired short- and long-term declarative memory for emotionally arousing material. Metyrapone did not impair short-term declarative memory but impaired long-term declarative memory for emotionally arousing and neutral material. Results demonstrate that adrenergic and corticosteroid hormonal systems differentially affect declarative memory for emotionally arousing and neutral material, and suggest that interactions between adrenal hormonal systems modulate emotionally arousing declarative memory in humans.
Maheu
Francoise S
FS
Laboratory of Human Psychoneuroendocrine Research, Douglas Hospital Research Center--McGill University, Montreal, PQ, Canada.
Joober
Ridha
R
Beaulieu
Serge
S
Lupien
Soriia J
SJ
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D000339:Affect / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D008797:Metyrapone / Q000008:administration & dosage / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D012463:Saliva / Q000737:chemistry
D000305:Adrenal Cortex Hormones; D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D006854:Hydrocortisone; D008797:Metyrapone