Synthesis and biological activity of some structural modifications of pancratistatin.
Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.
Rinner
Uwe
U
Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Hillebrenner
Heather L
HL
Adams
David R
DR
Hudlicky
Tomas
T
Pettit
George R
GR
D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D013329:Structure-Activity Relationship
D047151:Amaryllidaceae Alkaloids; D000970:Antineoplastic Agents; D007546:Isoquinolines; C044997:pancratistatin