Frequency of reduced vancomycin susceptibility and heterogeneous subpopulation in persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia.
Vancomycin susceptibility was checked in isolates from initial and final blood samples obtained from 22 patients with persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia. The minimum inhibitory concentration of vancomycin was determined using Etest and found to have increased in 2 pairs of isolates, and results of screening in 4 mu g vancomycin and a modified population analysis profile suggested heteroresistance in 3 isolates (13.6%). Heteroresistance is not a common cause of persistent or recurrent bacteremia.
Khosrovaneh
Amir
A
Section of Infectious Diseases, Department of Medicine, St. John Hospital and Medical Center, Detroit, Michigan 48236, USA.
Riederer
Kathleen
K
Saeed
Sajjad
S
Tabriz
M Shamse
MS
Shah
Amar R
AR
Hanna
Michel M
MM
Sharma
Mamta
M
Johnson
Leonard B
LB
Fakih
Mohammad G
MG
Khatib
Riad
R
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D018432:Drug Resistance, Multiple; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D014640:Vancomycin