title: Kaurane-type diterpene glycoside from the stem bark of Acanthopanax trifoliatus.
abstract: A new diterpene glycoside, acantrifoside D ( 1), as well as three known diterpenes (2 - 4) were isolated from the stem bark of Acanthopanax trifoliatus from Vietnam. Based on 1D and 2D NMR spectroscopic data, their chemical structures were determined to be 16alpha,17-dihydroxy- ent-kauran-19-oic acid 16- O-beta- D-glucopyranoside 19- O-beta- D-glucopyranosyl ester (1), 16alpha H,17-isovalerate- ent-kauran-19-oic acid (2), ent-kaur-16-en-19-oic acid ( 3), and ent-pimara-8(14),15-dien-19-oic acid (4). Compounds 2 - 4 had strong inhibitory effects against COX-1 in an in vitro assay, with IC50 values of 0.21, 0.15 and 0.19 mM, respectively.
authors.affiliation: Institute of Natural Products Chemistry, NCST, Nghiado, Caugiay, Hanoi, Vietnam.
authors.forename: Phan Van
authors.initials: PV
authors.lastname: Kiem
authors.forename: Xing Fu
authors.initials: XF
authors.lastname: Cai
authors.forename: Chau Van
authors.initials: CV
authors.lastname: Minh
authors.forename: Jung Joon
authors.initials: JJ
authors.lastname: Lee
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D051545:Cyclooxygenase 1; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D028001:Eleutherococcus; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000187:drug effects; D008565:Membrane Proteins; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis / Q000187:drug effects
chemical_list: D016861:Cyclooxygenase Inhibitors; D045786:Diterpenes, Kaurane; D006027:Glycosides; D007527:Isoenzymes; D008565:Membrane Proteins; D010936:Plant Extracts; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D011451:Prostaglandin-Endoperoxide Synthases