Effect of central administration of carnosine and its constituents on behaviors in chicks.
Even though their contents in the brain are high, the function of brain carnosine and its constituents has not been clarified. Both carnosine and anserine inhibited food intake in a dose dependent fashion when injected intracerebroventricularly. The constituents of carnosine, beta-alanine (beta-Ala) and l-histidine (His), also inhibited food intake, but their effects were weaker than carnosine itself. Co-administration with beta-Ala and His inhibited food intake similar to carnosine, but also altered other behaviors. Injection of carnosine induced hyperactivity and increased plasma corticosterone level, whereas beta-Ala plus His induced hypoactivity manifested as sleep-like behavior. This later effect seemed to be derived from beta-Ala, not His. These results suggest that central carnosine may act in the brain of chicks to regulate brain function and/or behavior in a manner different from its constituents.
Tomonaga
Shozo
S
Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812-8581, Japan.
Tachibana
Tetsuya
T
Takagi
Tomo
T
Saito
Ei-Suke
ES
Zhang
Rong
R
Denbow
D Michael
DM
Furuse
Mitsuhiro
M
D000818:Animals; D000831:Animals, Newborn; D000861:Anserine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D002336:Carnosine / Q000378:metabolism / Q000494:pharmacology*; D002645:Chickens; D003348:Cortisone / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D006639:Histidine / Q000378:metabolism / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D011595:Psychomotor Agitation / Q000378:metabolism; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012890:Sleep / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D015091:beta-Alanine / Q000378:metabolism / Q000494:pharmacology
D015091:beta-Alanine; D006639:Histidine; D002336:Carnosine; D000861:Anserine; D003348:Cortisone