title: An implicit learning task activates medial temporal lobe in patients with Parkinson's disease.
abstract: Recent studies provide evidence for an interaction between a declarative memory system, dependent on the medial temporal lobe (MTL), and a habit memory system, dependent on the basal ganglia. Using functional MRI, the authors studied this interaction when 1 system was compromised by neurological disease. Neural activity when performing a habit-learning task was compared in normal controls and subjects with Parkinson's disease (PD). Patients with PD showed less activation in the caudate nucleus and greater activation in a region of prefrontal cortex that has been associated with explicit memory retrieval. Patients with PD also showed activation of the MTL during the weather-prediction task. These findings are consistent with an interaction between memory systems of the MTL and the striatum.
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095-1563, USA.
authors.forename: Teena D
authors.initials: TD
authors.lastname: Moody
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Bookheimer
authors.forename: Zeba
authors.initials: Z
authors.lastname: Vanek
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Knowlton
mesh_terms: D001479:Basal Ganglia / Q000502:physiology; D002421:Caudate Nucleus / Q000033:anatomy & histology / Q000503:physiopathology; D003342:Corpus Striatum / Q000033:anatomy & histology / Q000503:physiopathology; D003463:Cues; D005260:Female; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000503:physiopathology; D012372:ROC Curve; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000502:physiology*