Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population.
BACKGROUND
Thrombospondin-1 (TSP-1) is very important in platelet adhesion and aggregation, inflammation, cell to cell interaction, and vascular smooth muscle cell proliferation. Therefore, it may play an important role in the progression of cardiovascular disease. Recently, the TSP-1 N700S variant was proposed to be a new genetic predictor for myocardial infarction (MI) in American population, but the hypothesis was not verified in two other populations. We investigated a possible association between the N700S polymorphism and MI in a Chinese Han population.


METHODS
We performed a case-control study including 406 patients who survived an acute MI before age 60 years and 400 age- and sex-matched controls. The N700S polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphism.


RESULTS
Of the 806 subjects participating in the study, only 7 of the heterozygotes and none of the homozygotes were detected for the 700S allele. The prevalence of the S allele in the healthy controls was less frequent than those of the west populations (0.3% vs. 11%). No association of the N700S polymorphism with an altered risk of MI was found in our study (GA vs. AA: OR=2.48; 95% CI, 0.48 to 12.86; P=0.46).


CONCLUSIONS
Our study suggested that the TSP-1 N700S polymorphism was rare and unrelated to MI in the Chinese Han population. Additional investigations should be performed in populations at different risk for coronary events in order to further elucidate the possible contribution of the polymorphism to cardiovascular disease.
Zhou
Xiaoyang
X
Division of Population Genetics, Cardiovascular Institute, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, PR China. xiaoyangzhou@hotmail.com
Huang
Jianfeng
J
Chen
Jianhong
J
Zhao
Jiangong
J
Ge
Dongliang
D
Yang
Wenjie
W
Gu
Dongfeng
D
D000328:Adult; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D012189:Retrospective Studies; D019700:Thrombospondin 1 / Q000235:genetics*; D014505:Urban Population
D019700:Thrombospondin 1