title: Bipolar and monopolar radiofrequency treatment of osteoarthritic knee articular cartilage: acute and temporal effects on cartilage compressive stiffness, permeability, cell synthesis, and extracellular matrix composition.
abstract: The cellular, biochemical, biomechanical, and histologic effects of radiofrequency-generated heat on osteoarthritic cartilage were assessed. Articular cartilage explants (n=240) from 26 patients undergoing total knee arthroplasty were divided based on Outerbridge grade (I or II/III) and randomly assigned to receive no treatment (controls) or monopolar or bipolar radiofrequency at 15 or 30 W. Both potentially beneficial and harmful effects of radiofrequency treatment of articular cartilage were noted. It will be vital to correlate data from in vitro and in vivo study of radiofrequency thermal chondroplasty to determine the clinical usefulness of this technique.
authors.affiliation: Comparative Orthopaedic Laboratory, University of Missouri, Columbia, MO 65211, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Cook
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kuroki
authors.forename: Keith
authors.initials: K
authors.lastname: Kenter
authors.forename: Kevin
authors.initials: K
authors.lastname: Marberry
authors.forename: Travis
authors.initials: T
authors.lastname: Brawner
authors.forename: Timothy
authors.initials: T
authors.lastname: Geiger
authors.forename: Prakash
authors.initials: P
authors.lastname: Jayabalan
authors.forename: B Sonny
authors.initials: BS
authors.lastname: Bal
mesh_terms: D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000473:pathology / Q000503:physiopathology; D019902:Chondrocytes / Q000378:metabolism; D024042:Collagen Type I / Q000378:metabolism; D024043:Collagen Type II / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D007150:Immunohistochemistry; D020370:Osteoarthritis, Knee / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D024042:Collagen Type I; D024043:Collagen Type II; D006025:Glycosaminoglycans