Convenient synthesis of alkylhydrazides by the cobalt-catalyzed hydrohydrazination reaction of olefins and azodicarboxylates.
Treatment of olefins 2 with 1.5 equiv of di-tert-butyl azodicarboxylate (3), 1 equiv of PhSiH3, and 1.5-5 mol % of the simple Co(III) catalyst 1 in ethanol at 23 degrees C affords the Markovnikov hydrazide product for a broad range of olefins in 62-94% yield.
Waser
Jérôme
J
Laboratorium für Organische Chemie, ETH Hönggerberg, CH-8093 Zürich, Switzerland.
Carreira
Erick M
EM