title: ent-Kaurene diterpenoids from Isodon oresbius.
abstract: Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC(50)=1.43 microg/ml.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiang
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Zong-Yu
authors.initials: ZY
authors.lastname: Wang
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D037602:Isodon / Q000737:chemistry*; D020014:K562 Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D045786:Diterpenes, Kaurane