title: Immunological aspects of heat-shock proteins-the optimum stress of life.
abstract: This review summarizes the complex role of heat-shock proteins (Hsp) in immune reactions, especially the cellular effects of heat-shock proteins during the recognition processes by innate immunity. The role of heat-shock proteins in the pathogenesis of two multifactorial diseases, i.e. inflammatory bowel disease (IBD) and atherosclerosis is highlighted. A new hypothesis on "immunodeficiency burden" is presented. According to this hypothesis, susceptibility to any multifactorial disease in any given subject and in the presence of specific environmental factors is the aggregate effect of polymorphisms resulting in the failure of protective immunity with consequent disease.
authors.affiliation: 3rd Department of Medicine, Faculty of Medicine, Semmelweis University, H-1125 Budapest, Kútvölgyi u.4., Budapest, Hungary. prohoz@kut.sote.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Prohászka
authors.forename: George
authors.initials: G
authors.lastname: Füst
mesh_terms: D001161:Arteriosclerosis / Q000276:immunology; D006360:Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007109:Immunity; D007113:Immunity, Innate; D015212:Inflammatory Bowel Diseases / Q000235:genetics / Q000276:immunology; D018448:Models, Immunological; D018832:Molecular Chaperones / Q000502:physiology; D013312:Stress, Physiological / Q000276:immunology
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones