title: [The influence of craniotomy on cytokines and immunological function].
abstract: The purpose of the study is to elucidate the effects of a craniotomy on patients regarding the cytokines and immunological function. TNF-alpha, IL-6, the CD4/8 ratio, cortisol, and WBC were all measured perioperatively in 29 patients. No serum TNF-alpha was detectable in any patients. The IL-6 level, cortisol and neutrophils all showed an increase with a peak at three hours after the end of operation. On the other hand, the lymphocytes and the CD4/8 ratio demonstrated a opposite pattern with a negative peak at the same time, however, these levels all gradually recovered to their preoperative states on the 7th operative day. The overall effect of a craniotomy was therefore found to correlate with the length of the operation.
authors.affiliation: Department of Neurosurgery, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Johnan-ku, Fukuoka 814-0180, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Ikeda
authors.forename: Shinya
authors.initials: S
authors.lastname: Ohshiro
authors.forename: Hideo
authors.initials: H
authors.lastname: Kimura
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukushima
authors.forename: Masamichi
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001932:Brain Neoplasms / Q000276:immunology / Q000601:surgery; D002561:Cerebrovascular Disorders / Q000276:immunology / Q000601:surgery; D003399:Craniotomy / Q000009:adverse effects*; D005260:Female; D019569:Hemifacial Spasm / Q000276:immunology / Q000601:surgery; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013312:Stress, Physiological / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D006854:Hydrocortisone