Rhodium(I)-catalyzed [2+2+1] cycloadditions of 1,3-dienes, alkenes, and CO.
Initial examples of a Rh(I)-catalyzed [2+2+1] reaction of diene-enes and CO are described. This method allows for the facile, efficient, and diastereoselective construction of a variety of alkenyl cyclopentanones in good to excellent yields. Control studies show that the diene moiety is required for this process as bis-enes do not give the [2+2+1] products under the same conditions.
Wender
Paul A
PA
Department of Chemistry, Stanford University, Stanford, California 94305, USA. wenderp@stanford.edu
Croatt
Mitchell P
MP
Deschamps
Nicole M
NM