Immature ovarian teratoma with hyponatremia and low antidiuretic hormone level.
BACKGROUND
Inappropriate antidiuretic hormone secretion syndrome is rare in patients with gynecologic tumors.


METHODS
A 22-year-old woman presented with inappropriate antidiuretic hormone secretion symptoms during the 2 months preceding the diagnosis of an immature ovarian teratoma. Vasopressin levels in serum and in the urine were very low. Restriction of water intake and surgical removal of the teratoma resulted in the definitive correction of the hyponatremia. This observation suggests that immature teratoma cells can produce a vasopressin-like factor, and the syndrome may be a sign of an ovarian malignancy.


CONCLUSIONS
Pelvic organs should be examined when the more common causes of inappropriate antidiuretic hormone secretion syndrome have been ruled out.
Roman
Horace
H
Department of Gynecology and Obstetrics, Groupe Hospitalier Sud Réunion, St. Pierre, Reunion Island, France. horace.roman@libertysurf.fr
Verspyck
Eric
E
Sentilhes
Loïc
L
Barau
Georges
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004326:Drinking; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D010051:Ovarian Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D013724:Teratoma / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D014667:Vasopressins / Q000097:blood
D014667:Vasopressins