title: Survival of patients with bronchiectasis after the first ICU stay for respiratory failure.
abstract: OBJECTIVE
  Respiratory failure (RF) is a frequent cause of death among patients with bilateral bronchiectasis. An ICU admission is commonly required, and neither short-term or long-term outcomes have been studied.
  
  
  METHODS
  We performed a retrospective study over a 10-year period (January 1990 to March 2000). All patients with bilateral bronchiectasis admitted for the first time in the medical ICU for RF were reviewed. Patients with cystic fibrosis were excluded.
  
  
  RESULTS
  Forty-eight patients (mean age +/- SD, 63 +/- 11 years; mean simplified acute physiology score [SAPS] II, 32 +/- 12) of whom 25% received long-term oxygen therapy (LTOT) were identified. All the patients were treated with intensive medical care, associated with noninvasive ventilation in 13 patients (27%), and 26 patients (54%) required intubation. Nine patients (19%) died in the ICU. The 1-year mortality rate was 40%. Among the variables recorded at ICU admission, age > 65 years (p = 0.002), SAPS II score > 32 (p = 0.012), use of LTOT (p = 0.047), and intubation (p = 0.027) were associated with reduced survival in univariate analysis by Cox regression. Multivariate analysis by Cox proportional hazard model showed that age > 65 years (relative risk [RR], 2.70; 95% confidence interval [CI], 1.15 to 6.29) and use of LTOT (RR, 2.52; 95% CI, 1.15 to 5.54) were independently associated with reduced survival.
  
  
  CONCLUSIONS
  We performed the first study providing information related to the impact of the first ICU stay for RF on long-term outcomes for patients with bilateral bronchiectasis. Age > 65 years and prior use of LTOT were associated with reduced survival.
authors.affiliation: Service de Réanimation Médicale et Maladies Infectieuses, Service de Pneumologie, Centre Hospitalier Universitaire de Rennes, Rennes, France. mathieu.dupont@chu-rennes.fr
authors.forename: Mathieu
authors.initials: M
authors.lastname: Dupont
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gacouin
authors.forename: Hervé
authors.initials: H
authors.lastname: Lena
authors.forename: Sylvain
authors.initials: S
authors.lastname: Lavoué
authors.forename: Graziella
authors.initials: G
authors.lastname: Brinchault
authors.forename: Philippe
authors.initials: P
authors.lastname: Delaval
authors.forename: Rémi
authors.initials: R
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001987:Bronchiectasis / Q000150:complications* / Q000401:mortality*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000401:mortality* / Q000628:therapy; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors