LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam.
Gradient HPLC coupled to DAD/UV, MS/MS and NMR has been applied to the rapid structure determination of three new isomeric divanilloylquinic acids from Fagara zanthoxyloides collected in Burkina Faso: 3,4-O-divanilloylquinic acid, 3,5-O-divanilloylquinic acid and 4,5-O-divanilloylquinic acid. Furthermore these new compounds named burkinabins A-C could play a useful role in sickle cell disease, as the active agents of Fagara zanthoxyloïdes are said to be unidentified aromatic compounds with carboxylic acid grouping (Adesanya, S.A., Sofowora, A., 1983. Biological standardisation of Zanthoxylum roots for antisickling activity. Planta Med. 48, 27-33).
Ouattara
Badioré
B
Université de Liège, Centre Interfacultaire de Recherche en Pharmacochimie des Substances Naturelles et Synthétiques (CPSNS), Laboratoire de Pharmacognosie, Avenue de l'Hôpital 1, B36, B-4000 Liège, Belgium.
Angenot
Luc
L
Guissou
Pierre
P
Fondu
Pierre
P
Dubois
Jacques
J
Frédérich
Michel
M
Jansen
Olivia
O
van Heugen
Jean-Claude
JC
Wauters
Jean-Noël
JN
Tits
Monique
M
D000755:Anemia, Sickle Cell / Q000378:metabolism; D000986:Antisickling Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004205:Cromolyn Sodium / Q000494:pharmacology; D006801:Humans; D007536:Isomerism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032106:Zanthoxylum / Q000737:chemistry*
D000986:Antisickling Agents; D010936:Plant Extracts; D011801:Quinic Acid; D014641:Vanillic Acid; D004205:Cromolyn Sodium