title: Polychlorinated androstanes from the burrowing sponge Cliona nigricans.
abstract: Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetrachlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy. fattoru@unina.it
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
authors.forename: Francesca
authors.initials: F
authors.lastname: Petrucci
authors.forename: Giorgio
authors.initials: G
authors.lastname: Bavestrello
authors.forename: Barbara
authors.initials: B
authors.lastname: Calcinai
authors.forename: Carlo
authors.initials: C
authors.lastname: Cerrano
authors.forename: Paola
authors.initials: P
authors.lastname: Di Meglio
authors.forename: Angela
authors.initials: A
authors.lastname: Ianaro
mesh_terms: D000731:Androstanes / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*
chemical_list: D000731:Androstanes; C494536:clionastatin A; C494535:clionastatin B