title: New concept in histopathological grading and staging of chronic hepatitis C infection at Sharkia Governorate, Egypt.
abstract: Hepatitis C virus (HCV) has been estimated by the WHO to infect 170 million patients worldwide, with a high prevalence rate (about 24.5%) among Egyptians. The disease could be presented with variable hepatic lesions ranging from mild inflammation, fibrosis, cirrhosis to even end stage liver disease and hepatocellular carcinoma. The Knodell histology activity index, published in 1981, was the first system of its type and is widely regarded as the benchmark for objective, semi-quantitative reproducible description of the various morphological lesions of chronic hepatitis. Other proposals for semi-quantitative evaluation have followed. In this study, when applying these systems on the present cases (109 liver biopsies taken from Egyptian patients infected with HCV), the authors found that the presented histopathological features may be unusual for any of the known scoring systems. Therefore, they suggested a new system for grading and staging of liver diseases in Egyptian patients infected with HCV. Accordingly, the degrees of necroinflammations are classified into 3 grades (1-3) and the progression of fibrosis is classified into 3 stages (1-3). The reduced numbers of grades and stages proposed in this study may be attributed to the rapid course among Egyptians who differ in environmental circumstances from abroad.
authors.affiliation: Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Amal M
authors.initials: AM
authors.lastname: Mangoud
authors.forename: Mostafa H
authors.initials: MH
authors.lastname: Eissa
authors.forename: Essam I
authors.initials: EI
authors.lastname: Sabee
authors.forename: Ibrahem A
authors.initials: IA
authors.lastname: Ibrahem
authors.forename: Alaa
authors.initials: A
authors.lastname: Ismail
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
authors.forename: Essam
authors.initials: E
authors.lastname: Nor Edin
authors.forename: Yousry
authors.initials: Y
authors.lastname: Mostafa
authors.forename: Yousry
authors.initials: Y
authors.lastname: Abuel-Magd
authors.forename: Afefy F
authors.initials: AF
authors.lastname: Afefy
authors.forename: Eman
authors.initials: E
authors.lastname: el-Shorbagy
authors.forename: Mahmoud
authors.initials: M
authors.lastname: el-Sadawy
authors.forename: Hosnia
authors.initials: H
authors.lastname: Ragab
authors.forename: Seham
authors.initials: S
authors.lastname: Mahrous
authors.forename: Amal
authors.initials: A
authors.lastname: Abdel Menem
authors.forename: Samia
authors.initials: S
authors.lastname: Etewa
authors.forename: Mostafa I
authors.initials: MI
authors.lastname: Hassan
authors.forename: Khalid
authors.initials: K
authors.lastname: Lakouz
authors.forename: Khalid
authors.initials: K
authors.lastname: Abdel-Aziz
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Saber
authors.forename: Gaber
authors.initials: G
authors.lastname: el-Hady
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004534:Egypt; D005260:Female; D019698:Hepatitis C, Chronic / Q000145:classification* / Q000473:pathology* / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D008103:Liver Cirrhosis / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged