title: Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.
abstract: For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C(15) showed the most significant dual COX/5-LOX inhibitory activity.
authors.affiliation: College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea.
authors.forename: Yurngdong
authors.initials: Y
authors.lastname: Jahng
authors.forename: Long-Xuan
authors.initials: LX
authors.lastname: Zhao
authors.forename: Yoon-Soo
authors.initials: YS
authors.lastname: Moon
authors.forename: Arjun
authors.initials: A
authors.lastname: Basnet
authors.forename: Eun-kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Ju
authors.forename: Tae Cheon
authors.initials: TC
authors.lastname: Jeong
authors.forename: Eung-Seok
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000201:enzymology; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D016859:Lipoxygenase Inhibitors