Hitchhiking without covalent integration.
In eukaryotes, many latent viruses attach to mitotic chromosomes noncovalently for effective partitioning in dividing cells. For different viruses, the cis and trans elements encoded by the episomes have been effectively defined but the chromosomal "receptors" for such tethering have remained elusive. In this issue of Cell, give us a first insight into the cellular protein machinery important for animal papillomavirus retention.
Botchan
Michael
M
Department of Cell and Molecular Biology and Division of Biochemistry and Molecular Biology, The University of California, Berkeley, Berkeley, CA 94720, USA.
D000818:Animals; D001665:Binding Sites; D052688:Bovine papillomavirus 1 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018797:Cell Cycle Proteins; D002843:Chromatin / Q000378:metabolism; D002875:Chromosomes / Q000378:metabolism* / Q000821:virology; D004279:DNA, Viral / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D008938:Mitosis; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010957:Plasmids; D014157:Transcription Factors; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014779:Virus Replication; D000092468:Bromodomain Containing Proteins
D018797:Cell Cycle Proteins; D002843:Chromatin; D004279:DNA, Viral; D004268:DNA-Binding Proteins; D006657:Histones; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors; D014764:Viral Proteins; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C486694:Brd4 protein, mouse