[Switching off the estrogen effect and approaches to its correction].
Data are summarized on experimental means of induction of PSEE and its modification/prevention with the aim to achieve optimal ratio of estrogenic effects (as low as possible genotoxicity in combination with satisfactory and excessive hormonal action). Among studied agents were ethanol, tobacco smoke, irradiation, aging (as PSEE inductors) and carnosine, N-acetylcystein, vit. E and C, melatonin, swimming and antiestrogen ICI 182780 (as PSEE modificators).
Bershteĭn
L M
LM
N. N. Petrov Research Institute of Oncology, 68 Leningradskaya St., Pesochny, 197758, St. Petersburg, Russia.
Tsyrlina
E V
EV
Poroshina
T E
TE
Vasil'ev
D A
DA
Kovalenko
I G
IG
D000111:Acetylcysteine / Q000494:pharmacology; D000375:Aging / Q000502:physiology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004958:Estradiol / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D020847:Estrogen Receptor Modulators / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology* / Q000633:toxicity; D000431:Ethanol / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D000077267:Fulvestrant; D005720:Gamma Rays; D008550:Melatonin / Q000494:pharmacology; D009929:Organ Size; D010052:Ovariectomy; D010805:Physical Conditioning, Animal; D051381:Rats; D012907:Smoking / Q000009:adverse effects; D013550:Swimming; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects* / Q000528:radiation effects; D014807:Vitamin D / Q000494:pharmacology
D000975:Antioxidants; D020847:Estrogen Receptor Modulators; D004967:Estrogens; D014807:Vitamin D; D000077267:Fulvestrant; D000431:Ethanol; D004958:Estradiol; D002336:Carnosine; D008550:Melatonin; D001205:Ascorbic Acid; D000111:Acetylcysteine