Fluid flow electrophoresis model.
Molecular delivery via electroporation is typically done via molecular diffusion and tissue perfusion. The inherent variability in those distribution methods limits the efficacy of this medical and laboratory technique. Electrophoresis has been shown to improve the distribution and placement of the molecule [Gene Therapy 9 (2002) 1286]. This paper presents a fluid flow model for electrophoresis in tissues. Parallel plate and four-needle needle array electrodes are the electrodes modeled as the delivery devices. The parallel plate electrode produces a homogeneous distribution of the analyte but the needle array electrode creates a peak where the electric field effects diminish.
Hickey
Joseph D
JD
Department of Chemical Engineering, University of South Florida, 4202 E. Fowler Ave. ENB 118, Tampa, FL 33620, USA. hickey@eng.usf.edu
Gilbert
Richard
R
D000818:Animals; D003198:Computer Simulation; D003238:Connective Tissue / Q000737:chemistry* / Q000528:radiation effects*; D004058:Diffusion / Q000528:radiation effects; D016503:Drug Delivery Systems / Q000379:methods; D004566:Electrodes; D004586:Electrophoresis / Q000379:methods*; D006801:Humans; D044085:Microfluidics / Q000379:methods*; D008954:Models, Biological; D011188:Potassium / Q000008:administration & dosage / Q000737:chemistry / Q000528:radiation effects
D011188:Potassium