Synthesis and cell affinity of functionalized poly(L-lactide-co-beta-malic acid) with high molecular weight.
A novel functionalized biodegradable poly(L-lactide-co-beta-benzyl malolactonate) (p-PLMA) with high molecular weight was synthesized through ring-opening copolymerization. Three p-PLMA copolymers with different beta-benzyl malolactonate content were synthesized. The molecular weight (M(w)) and tensile strength of the copolymer with 4 mol% beta-benzyl malolactonate content were 179,800 and 19.0MPa respectively, the molecular weight (M(w)) and tensile strength of p-PLMA decreased with beta-benzyl malolactonate content increasing. The hydrophilicity of the de-protected product: poly(L-lactide-co-beta-malic acid) (d-PLMA) increased with malic acid content increasing. The results of 3T3 mice fibroblasts cultivated on d-PLMA films showed that the cell adhesion on d-PLMA was better than that of PLLA and the cell attached efficiency of d-PLMA with 8 mol% malic acid content was the highest. The cells grew well both on the surface and inside of d-PLMA scaffolds. The cell affinity of d-PLMA was better than that of PLLA.
He
Bin
B
State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China.
Wan
Yuqing
Y
Bei
Jianzhong
J
Wang
Shenguo
S
D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism; D019344:Lactic Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008293:Malates / Q000737:chemistry* / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D008956:Models, Chemical; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology*; D011100:Polyglycolic Acid / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013718:Tensile Strength; D013997:Time Factors; D014867:Water / Q000737:chemistry
D001672:Biocompatible Materials; D008293:Malates; D011091:Polyesters; D011108:Polymers; C494686:poly(L-lactide-co-beta-malic acid); C121060:poly(malic acid); D014867:Water; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); C030298:malic acid