Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters.
A series of (3-pyridin-2-yl-thiouriedo)alkanoic acid esters (5a-j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g-j) displayed significant inhibitory activity of the enzyme.
Farhanullah
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
Sil
Diptesh
D
Tripathi
Brajendra K
BK
Srivastava
Arvind K
AK
Ram
Vishnu Ji
VJ
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D004952:Esters; D005952:Glucose-6-Phosphatase