title: Novel function of PS2V: change in conformation of tau proteins.
abstract: Neurofibrillary tangles (NFTs) are associated with many neurodegenerative disorders, such as Alzheimer's disease (AD). The major components of NFTs are hyper-phosphorylated tau proteins. The alternatively spliced form of the presenilin-2 (PS2) gene (PS2V) has been observed in sporadic AD brains. However, it is not known whether there is a relationship between tau aggregation/hyper-phosphorylation and PS2V expression. In this manuscript, we make the first report of PS2V alterations in the conformation of the tau protein (unknown form of tau) in the human neuroblastoma cell line.
authors.affiliation: Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nishikawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Manabe
authors.forename: Taiichi
authors.initials: T
authors.lastname: Katayama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Matsuzaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yanagita
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okuda
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Bando
authors.forename: Masaya
authors.initials: M
authors.lastname: Tohyama
mesh_terms: D045744:Cell Line, Tumor; D015870:Gene Expression; D006801:Humans; D015151:Immunoblotting; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D009447:Neuroblastoma / Q000378:metabolism; D010766:Phosphorylation; D053766:Presenilin-2; D011487:Protein Conformation; D014415:Tunicamycin / Q000494:pharmacology; D016875:tau Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; D016875:tau Proteins; D014415:Tunicamycin