Biomimetic model of skeletal muscle isometric contraction: II. A phenomenological model of the skeletal muscle excitation-contraction coupling process.
This paper describes a new macroscopic, phenomenological model of the skeletal muscle excitation-contraction coupling process, as represented by four principal and consecutive compartments (biophysical, biochemical, and biomechanical phases) characteristic of isometric excitation-contraction coupling in mammalian skeletal muscle, and coupled by a system of simultaneous, first-order linear ordinary differential equations. The model is based upon biological compartmental transport kinetics and irreversible thermodynamic energy transformation, and represents a distinct improvement over other biomimetic models. The model was derived using physiological parameter data published in the literature, and validated using MATLAB R12.
Neidhard-Doll
A T
AT
Department of Biomedical, Industrial, and Human Factors Engineering, 207, Russ Engineering Center, Wright State University, Dayton, OH 45435-0001, USA.
Phillips
C A
CA
Repperger
D W
DW
Reynolds
D B
DB
D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology*; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000502:physiology*
D002118:Calcium