Effect of treatment with bupropion on EEG sleep: relationship to antidepressant response.
The objective of this study was to assess whether treatment with sustained-release bupropion (Wellbutrin-SR) produces alterations in electroencephalographic (EEG) sleep that are associated with clinical response to the drug. EEG sleep was measured in 20 patients with unipolar major depressive disorder before and after treatment with sustained-release bupropion. Each EEG sleep session consisted of two consecutive nights. Treatment with bupropion lasted for 8 wk. Compared to EEG sleep measures at baseline, treatment with bupropion significantly lengthened REM latency, increased REM activity and density during the first REM period, and increased total REM density. Differential response to treatment was associated with changes in REM activity and density, but not with REM latency. However, in contrast to many other antidepressants, REM sleep was not suppressed.
Ott
Geoffrey E
GE
Interdepartmental Training Program for Neuroscience, UCLA, CA 90048, USA.
Rao
Uma
U
Lin
Keh-Ming
KM
Gertsik
Lev
L
Poland
Russell E
RE
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000627:therapeutic use*; D016642:Bupropion / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000523:psychology*; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D018687:Antidepressive Agents, Second-Generation; D003692:Delayed-Action Preparations; D016642:Bupropion