Bioavailability of tyrosol, an antioxidant phenolic compound present in wine and olive oil, in humans.
Tyrosol is a phenolic compound present in two of the traditional components of the Mediterranean diet: wine and virgin olive oil. The presence of tyrosol has been described in red and white wines. Tyrosol is also present in vermouth and beer. Tyrosol has been shown to be able to exert antioxidant activity in in vitro studies. Oxidation of low-density lipoprotein (LDL) appears to occur predominantly in arterial intima in microdomains sequestered from antioxidants of plasma. The antioxidant content of the LDL particle is critical for its protection. Thus, phenolics, which are able to bind LDL, could be effective in preventing lipid peroxidation and atherosclerotic processes. The ability of tyrosol to bind human LDL has been reported. We have demonstrated the bioavailability of tyrosol in humans from virgin olive oil in its natural form. Urinary tyrosol increased, reaching a peak at 0-4 h after virgin olive oil administration. Men and women showed a different pattern of urinary excretion of tyrosol. Moreover, tyrosol is absorbed in a dose-dependent manner after sustained and moderate doses of virgin olive oil. In summary, our results suggest that tyrosol from wine or virgin olive oil could exert beneficial effects on human health in vivo if its biological properties are confirmed in in vivo studies.
Covas
M I
MI
Lipids and Cardiovascular Epidemiology Unit, Municipal Institute of Medical Research, Barcelona, Spain.
Miró-Casas
E
E
Fitó
M
M
Farré-Albadalejo
M
M
Gimeno
E
E
Marrugat
J
J
De La Torre
R
R
D000975:Antioxidants / Q000378:metabolism*; D001682:Biological Availability; D008078:Cholesterol, LDL / Q000097:blood; D038441:Diet, Mediterranean; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D000069463:Olive Oil; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D010938:Plant Oils / Q000493:pharmacokinetics*; D012737:Sex Factors; D014920:Wine
D000975:Antioxidants; D008078:Cholesterol, LDL; D000069463:Olive Oil; D010938:Plant Oils; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol