title: Fluid-dynamical basis of the embryonic development of left-right asymmetry in vertebrates.
abstract: Experimental work in developmental biology has recently shown in mice that fluid flow driven by rotating cilia in the node, a structure present in the early stages of growth of vertebrate embryos, is responsible for determining the normal development of the left-right axis, with the heart on the left of the body, the liver on the right, and so on. The role of physics, in particular, of fluid dynamics, in the process is one of the important questions that remain to be answered. We show with an analysis of the fluid dynamics of the nodal flow in the developing embryo that the leftward flow that has been experimentally observed may be produced by the monocilia driving it being tilted toward the posterior. We propose a model for morphogen transport and mixing in the nodal flow and discuss how the development of left-right asymmetry might be initiated.
authors.affiliation: Laboratorio de Estudios Cristalográficos, Consejo Superior de Investigaciones Científicas, E-18071 Granada, Spain. julyan@lec.ugr.es
authors.forename: Julyan H E
authors.initials: JH
authors.lastname: Cartwright
authors.forename: Oreste
authors.initials: O
authors.lastname: Piro
authors.forename: Idan
authors.initials: I
authors.lastname: Tuval
mesh_terms: D000818:Animals; D019521:Body Patterning; D005314:Embryonic and Fetal Development; D008962:Models, Theoretical; D014714:Vertebrates / Q000196:embryology*