title: Allelotyping of gastrointestinal nasal-type NK/T-cell lymphoma.
abstract: Nasal-type natural killer/T-cell lymphoma (NKL) is a rare but distinct malignancy that often involves the mid-facial region and the gastrointestinal tract. This study is the first genome-wide allelotyping analysis on this rare lymphoma. We applied 382 microsatellite markers covering loci which spanned 22 autosomes to screen for allelic imbalances (AI) in six intestinal NKL. The most common chromosomal regions of allelic imbalances were found in 11p, 9q and 13q. Novel spots of allelic losses spots found at 2p21, 2q37.22, 18p11.21 and 18q12.1. In spite of presence of a few recurrent loci of imbalances, the allelotyping results show that NKL is heterogeneous.
authors.affiliation: Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T. Hong Kong SAR, China.
authors.forename: Maxim
authors.initials: M
authors.lastname: Wan
authors.forename: John
authors.initials: J
authors.lastname: Chow
authors.forename: Kenny
authors.initials: K
authors.lastname: Lei
authors.forename: Wing
authors.initials: W
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D007694:Killer Cells, Natural / Q000473:pathology*; D019656:Loss of Heterozygosity / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009669:Nose Neoplasms / Q000235:genetics / Q000473:pathology; D016133:Polymerase Chain Reaction