p53 designer genes for the modern mouse.
Major efforts are underway to develop molecular strategies that target the p53 pathway for the treatment of cancer. Mouse strains with humanized p53 sequences that present the precise human DNA-binding domain as mutation target could be informative models to test p53 rescue drugs, and to explore experimentally the causes of human tumor mutations.
Hergenhahn
Manfred
M
Department of Genetic Alterations in Carcinogenesis, German Cancer Research Center, Heidelberg, Germany.
Luo
Jun-Li
JL
Hollstein
Monica
M
D000818:Animals; D016158:Genes, p53 / Q000235:genetics*; D005818:Genetic Engineering; D024861:Genetic Enhancement; D006801:Humans; D051379:Mice