Antierythropoietin antibody-induced pure red cell aplasia: posttransplant evolution.
Pure red cell aplasia is a rare complication of recombinant human erythropoietin (rHuEPO) treatment, which physicians should consider once the more frequent causes of hyporegenerative anemia have been excluded. To our knowledge, no pediatric cases have been described. In our patient, cyclosporin A treatment enabled a reduction in the number of transfusions and the risk of hyperimmunization. After transplantation, our patient's hemoglobin level has remained normal and stable.
Alonso Melgar
Angel
A
Pediatric Nephrology Unit, Hospital "La Paz", Madrid, Spain.
Melgosa Hijosa
Marta
M
Pardo de la Vega
Rafael
R
García Meseguer
Carmen
C
Navarro Torres
Mercedes
M
D000293:Adolescent; D000906:Antibodies / Q000276:immunology*; D004921:Erythropoietin / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011994:Recombinant Proteins; D012010:Red-Cell Aplasia, Pure / Q000276:immunology* / Q000601:surgery
D000906:Antibodies; D011994:Recombinant Proteins; D004921:Erythropoietin