Oxidative stress and nutritional prevention in autoimmune rheumatic diseases.
The hypothesis that oxidative stress favours flogistic and immune processes inducing autoimmune rheumatic diseases (ARDs) and their complications is still under discussion. In this review we take into consideration both the aetiopathological role of the diet in such diseases and the possible efficacy of dietary supports as adjuvants for the usual specific therapies. Moreover, we shall examine the hypothetical pathophysiological role of oxidative stress on ARDs and their complications, the methods for its evaluation and the possibility of intervening on oxidative pathways by means of nutritional modulation. It is possible that in the future we will be able to control connective pathology by associating an immuno-modulating therapy ('re-educating') with natural products having an anti-oxidant activity to current immunosuppressive treatment (which has potentially toxic effects).
Sukkar
Samir G
SG
Dietetics and Clinical Nutrition Unit, University-Hospital San Martino, Largo Rosanna Benzi 10, Genoa, Italy. samir.sukkar@hsanmartino.liguria.it
Rossi
Edoardo
E
D001327:Autoimmune Diseases / Q000178:diet therapy* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D004032:Diet; D004035:Diet Therapy; D019587:Dietary Supplements; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D009747:Nutritional Physiological Phenomena; D018384:Oxidative Stress / Q000276:immunology / Q000502:physiology; D017382:Reactive Oxygen Species / Q000276:immunology / Q000378:metabolism; D012216:Rheumatic Diseases / Q000178:diet therapy* / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control
D017382:Reactive Oxygen Species