title: [Isolated familial corpus callosum agenesis prognosis].
abstract: Agenesia of corpus callosum belongs to a group of cerebral malformations whose prognosis is uncertain. In such cases, assessment of prognosis may benefit from eventual associated fetal, obstetrical or familial features. We report a patient with an isolated corpus callosum agenesia that led to the discovery of a similar malformation in her father. This observation demonstrates that some forms of isolated and familial corpus callosum agenesia could have a favorable outcome. However, the difficulty of the assessment of prognosis in isolated corpus callosum agenesia is emphasized and the question of parental RMI exploration in such a peculiar context is raised.
authors.affiliation: Service de cytogénétique, centre hospitalier régional d'Orléans, 45000 Orléans, France.
authors.forename: S
authors.initials: S
authors.lastname: Nizard
authors.forename: M A
authors.initials: MA
authors.lastname: Barthez-Carpentier
authors.forename: A
authors.initials: A
authors.lastname: Gelot
authors.forename: C
authors.initials: C
authors.lastname: Hebert
authors.forename: M
authors.initials: M
authors.lastname: Abimelech
authors.forename: O
authors.initials: O
authors.lastname: Esperandieu
mesh_terms: D000328:Adult; D061085:Agenesis of Corpus Callosum; D000013:Congenital Abnormalities / Q000235:genetics*; D003337:Corpus Callosum / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D010375:Pedigree; D011379:Prognosis