title: In vitro skin penetration of dazmegrel delivered with a bioelastic matrix.
abstract: The penetration of dazmegrel, a selective thromboxane synthetase inhibitor, through excised human and greyhound skin was measured. A bioelastic matrix was used for topical delivery. Results demonstrated that dazmegrel readily penetrated the skin. Penetration through greyhound skin was significantly greater than penetration through human skin. Penetration through greyhound skin was not significantly different between 4, 24, and 48 h of exposure for the low and intermediate doses studied.
authors.affiliation: Department of Anatomy, Physiology, & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. kemppbw@auburn.edu
authors.forename: Barbara W
authors.initials: BW
authors.lastname: Kemppainen
authors.forename: Dan W
authors.initials: DW
authors.lastname: Urry
authors.forename: Chi-Xiang
authors.initials: CX
authors.lastname: Luan
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Steven F
authors.initials: SF
authors.lastname: Swaim
authors.forename: Saryu
authors.initials: S
authors.lastname: Goel
mesh_terms: D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D010539:Permeability; D012869:Skin Absorption
chemical_list: D004791:Enzyme Inhibitors; D007093:Imidazoles; C039242:dazmegrel