title: Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART.
abstract: We studied the predictive value of self-reported adherence and plasma drug concentrations on virological rebound to HAART. Among 238 participants in the AdICoNA study who had viral load < or = 500 copies/ml, 42 (17.6%) experienced virological rebound by 96 weeks. Both self-reported non-adherence and sub-optimal concentration were independently associated with a higher risk of virological rebound.
authors.affiliation: Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Roma, Italy. antinori@inmi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Antinori
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cozzi-Lepri
authors.forename: Adriana
authors.initials: A
authors.lastname: Ammassari
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Trotta
authors.forename: David
authors.initials: D
authors.lastname: Nauwelaers
authors.forename: Richard
authors.initials: R
authors.lastname: Hoetelmans
authors.forename: Rita
authors.initials: R
authors.lastname: Murri
authors.forename: Sara
authors.initials: S
authors.lastname: Melzi
authors.forename: Pasquale
authors.initials: P
authors.lastname: Narciso
authors.forename: Paola
authors.initials: P
authors.lastname: Nasta
authors.forename: Mauro
authors.initials: M
authors.lastname: Zaccarelli
authors.forename: Paola
authors.initials: P
authors.lastname: Santopadre
authors.forename: Jacopo
authors.initials: J
authors.lastname: Vecchiet
authors.forename: Crescenzo Maria
authors.initials: CM
authors.lastname: Izzo
authors.forename: Antonella d'Arminio
authors.initials: Ad
authors.lastname: Maonforte
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D017320:HIV Protease Inhibitors / Q000097:blood*; D006801:Humans; D007558:Italy; D010349:Patient Compliance; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood; D018894:Reverse Transcriptase Inhibitors / Q000097:blood*; D011795:Surveys and Questionnaires; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors