Investigation of intermolecular interaction in molecular complex of tryptamine and benzoic acid by solid-state 2D NMR.
Solid-state NMR spectra and powder X-ray diffraction of the two-component molecular complex composed of tryptamine and benzoic acid were observed to investigate the intermolecular interaction in the molecular complex. 1D (13)C CP/MAS NMR spectrum and powder X-ray diffraction pattern of the complex was clearly different from the convolution of each spectrum of the single component. 2D (1)H-(13)C heteronuclear-correlation (HETCOR) NMR technique indicated that the intermolecular interaction between the primary amine of tryptamine and the carboxyl group of benzoic acid must be related to the complex formation.
Terakita
Akira
A
Analytical Development Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan. Terakita_Akira@takeda.co.jp
Matsunaga
Hirokazu
H
Ueda
Takahiro
T
Eguchi
Taro
T
Echigoya
Midori
M
Umemoto
Kazuichi
K
Godo
Masayuki
M
D019817:Benzoic Acid / Q000032:analysis* / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D014363:Tryptamines / Q000032:analysis* / Q000737:chemistry*
D014363:Tryptamines; C030820:tryptamine; D019817:Benzoic Acid