title: Fusarium infection in hematopoietic stem cell transplant recipients.
abstract: To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)--matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.
authors.affiliation: University Hospital, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. mnucci@hucff.ufrj.br
authors.forename: Marcio
authors.initials: M
authors.lastname: Nucci
authors.forename: Kieren A
authors.initials: KA
authors.lastname: Marr
authors.forename: Flavio
authors.initials: F
authors.lastname: Queiroz-Telles
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Martins
authors.forename: Plinio
authors.initials: P
authors.lastname: Trabasso
authors.forename: Silvia
authors.initials: S
authors.lastname: Costa
authors.forename: Julio C
authors.initials: JC
authors.lastname: Voltarelli
authors.forename: Arnaldo L
authors.initials: AL
authors.lastname: Colombo
authors.forename: Alexander
authors.initials: A
authors.lastname: Imhof
authors.forename: Ricardo
authors.initials: R
authors.lastname: Pasquini
authors.forename: Angelo
authors.initials: A
authors.lastname: Maiolino
authors.forename: Cármino A
authors.initials: CA
authors.lastname: Souza
authors.forename: Elias
authors.initials: E
authors.lastname: Anaissie
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005670:Fusarium; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology; D009894:Opportunistic Infections / Q000453:epidemiology* / Q000209:etiology; D014481:United States / Q000453:epidemiology