title: Mapping distributed sources of cortical rhythms in mild Alzheimer's disease. A multicentric EEG study.
abstract: The study aimed at mapping (i) the distributed electroencephalographic (EEG) sources specific for mild Alzheimer's disease (AD) compared to vascular dementia (VaD) or normal elderly people (Nold) and (ii) the distributed EEG sources sensitive to the mild AD at different stages of severity. Resting EEG (10-20 electrode montage) was recorded from 48 mild AD, 20 VaD, and 38 Nold subjects. Both AD and VaD patients had 24-17 of mini mental state examination (MMSE). EEG rhythms were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were modeled by low resolution brain electromagnetic tomography (LORETA). Regarding issue i, there was a decline of central, parietal, temporal, and limbic alpha 1 (low alpha) sources specific for mild AD group with respect to Nold and VaD groups. Furthermore, occipital alpha 1 sources showed a strong decline in mild AD compared to VaD group. Finally, distributed theta sources were largely abnormal in VaD but not in mild AD group. Regarding issue ii, there was a lower power of occipital alpha 1 sources in mild AD subgroup having more severe disease. Compared to previous field studies, this was the first investigation that illustrated the power spectrum profiles at the level of cortical (macroregions) EEG sources in mild AD patients having different severity of the disease with respect to VaD and normal subjects. Future studies should evaluate the clinical usefulness of this approach in early differential diagnosis, disease staging, and therapy monitoring.
authors.affiliation: Dipartimento di Fisiologia Umana e Farmacologia, Sezione di EEG ad Alta Risoluzione, Universita degli Studi di Roma La Sapienza, Rome, Italy. claudio.babiloni@uniroma1.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Giuliano
authors.initials: G
authors.lastname: Binetti
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cassetta
authors.forename: Daniele
authors.initials: D
authors.lastname: Cerboneschi
authors.forename: Gloria
authors.initials: G
authors.lastname: Dal Forno
authors.forename: Claudio
authors.initials: C
authors.lastname: Del Percio
authors.forename: Florinda
authors.initials: F
authors.lastname: Ferreri
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
authors.forename: Bartolo
authors.initials: B
authors.lastname: Lanuzza
authors.forename: Carlo
authors.initials: C
authors.lastname: Miniussi
authors.forename: Davide V
authors.initials: DV
authors.lastname: Moretti
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Roberto D
authors.initials: RD
authors.lastname: Pascual-Marqui
authors.forename: Guido
authors.initials: G
authors.lastname: Rodriguez
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Romani
authors.forename: Serenella
authors.initials: S
authors.lastname: Salinari
authors.forename: Franca
authors.initials: F
authors.lastname: Tecchio
authors.forename: Paolo
authors.initials: P
authors.lastname: Vitali
authors.forename: Orazio
authors.initials: O
authors.lastname: Zanetti
authors.forename: Filippo
authors.initials: F
authors.lastname: Zappasodi
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D015140:Dementia, Vascular / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests