title: Prostatic acid phosphatase: a possible diagnostic marker of intravascular large B-cell lymphoma.
abstract: OBJECTIVE
  Intravascular large B-cell lymphoma (IVL) has been treated as fever of unknown origin (FUO), and many patients have been treated inadequately based on incorrect diagnoses. We previously cares for a patient with IVL who tested positive for prostatic acid phosphatase (PAP), a marker of prostate cancer. Since then, we have regularly examined this mather when IVL was suspected to investigate the usefulness of PAP as a diagnostic marker for IVL. We retrospectively evaluated the usefulness of PAP as diagnostic marker of IVL.
  
  
  METHODS
  We reviewed the clinical courses of 5 patients with IVL (3 males, 2 females) in comparison with 23 controls with hematologic malignancies other than IVL.
  
  
  RESULTS
  Serum levels of PAP were elevated in all 5 patients with IVL and 2 of the 23 controls. The difference was statistically significant using a chi-squared test (p=0.0002). The sensitivity and specificity of PAP were 100% and 91%, respectively, in the diagnosis of IVL. Its serum levels were closely associated with disease status.
  
  
  CONCLUSIONS
  This study suggests that PAP might be a useful marker for the screening and assessment of disease activity and responses to the treatment of IVL.
authors.affiliation: Department of Hematology, Toranomon Hospital, Tokyo, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kishi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kami
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusumi
authors.forename: Tomoka
authors.initials: T
authors.lastname: Mineyama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kato
authors.forename: Tamae
authors.initials: T
authors.lastname: Hamaki
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Ueyama
authors.forename: Shigesaburo
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Morinaga
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Muto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Taniguchi
mesh_terms: D000135:Acid Phosphatase; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D017027:Protein Tyrosine Phosphatases / Q000097:blood*; D012189:Retrospective Studies; D019043:Vascular Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase; D017027:Protein Tyrosine Phosphatases