title: A ruthenium-grafted hydrotalcite as a multifunctional catalyst for direct alpha-alkylation of nitriles with primary alcohols.
abstract: Treatment of a hydrotacite, Mg6Al2(OH)16CO3, with an aqueous solution of RuCl3.nH2O afforded a monomeric Ru(IV) species on the surface of the hydrotalcite. This novel Ru-grafted hydrotalcite (Ru/HT) efficiently catalyzed alpha-alkylation of nitriles with primary alcohols through the cooperative catalysis between the Ru species and the surface base sites. The catalyst system could be further extended for the one-pot synthesis of alpha,alpha-dialkylated phenylacetonitriles via the base-catalyzed Michael reaction of alpha-alkylated phenylacetonitrile with activate olefins.
authors.affiliation: Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Motokura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishimura
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Mori
authors.forename: Tomoo
authors.initials: T
authors.lastname: Mizugaki
authors.forename: Kohki
authors.initials: K
authors.lastname: Ebitani
authors.forename: Kiyotomi
authors.initials: K
authors.lastname: Kaneda