Cytochrome p450 1Al gene polymorphisms in patients with psoriatic arthritis.
OBJECTIVE
To investigate the associations of cytochrome p450 1A1 (CYP1A1) gene polymorphisms with susceptibility to psoriatic arthritis in Taiwan.


METHODS
CYP1A1 gene polymorphisms were determined in 52 patients with psoriatic arthritis and in 90 healthy controls by polymerase chain reaction/restriction fragment length polymorphism.


RESULTS
The genotype frequency of CYP1A1 4889A/G was significantly increased in patients with psoriatic arthritis in comparison with healthy controls. The phenotype frequency of CYP1A1 4889G was also significantly increased in patients with psoriatic arthritis. The genotype frequency of CYP1A1 4887C/A was significantly higher in patients with psoriatic arthritis than in controls. The allele and phenotype frequencies of 4887A were also significantly increased in patients with psoriatic arthritis. We also found that the association of CYP1A1 4887A with psoriatic arthritis was independent of 4889G but a synergistic effect was present between CYP1A1 4887A and 4889G. The CYP1A1 4889A/G and 4887C/A polymorphisms were not associated with the manifestations and severity of psoriatic arthritis.


CONCLUSIONS
CYP1A1 4887A and 4889G may be precipitating factors for susceptibility to psoriatic arthritis in Taiwan. An additive effect was found between CYP1A1 4887A and 4889G.
Yen
J H
JH
Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan, ROC. jehsye@kmu.edu.tw
Tsai
W C
WC
Lin
C H
CH
Ou
T T
TT
Hu
C J
CJ
Liu
H W
HW
D015535:Arthritis, Psoriatic / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D016001:Confidence Intervals; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015995:Prevalence; D011336:Probability; D018570:Risk Assessment; D013624:Taiwan / Q000453:epidemiology
D003577:Cytochrome P-450 Enzyme System; D019363:Cytochrome P-450 CYP1A1