[Electrically stimulated olfactory evoked potential in olfactory-lesioned rabbit].
OBJECTIVE
To develop olfactory dysfunctioned animal model by injuring olfactory blub(s) and to investigate the characteristics of olfactory evoked potential.


METHODS
The changes of OEP in rabbits were observed at 24 h, 48 h and 1 w after olfactory bulb(s) were electrolytically injured. The pathological and ultrastructural changes of olfactory mucosa and olfactory bulb were also observed.


RESULTS
When unilateral olfactory bulb was damaged, N2 vanished with elongated latencies and lowered amplitudes of N1 and P1. When both olfactory bulbs were damaged, N1 and N2 were absent, only P1 could be recorded. The latency was extended obviously and the amplitude had a big change. Histopathology and ultrastructure showed that there were a lot of inflammatory cells and degenerated neurons scattered around OB 24 hours to 48 hours after injure. It was observed that the olfactory cilia had distraction perversion and colliquefaction changes.


CONCLUSIONS
Different degree of olfactory bulb injury caused different effect on OEPs. These changes of potential were based on the histopathology and ultrastructure.
Wei
Yong-xiang
YX
Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China. weiyongxiang@vip.sina.com
Han
De-min
DM
Cai
Zhen
Z
Yang-Ling
Liu
Xiao-chao
XC
Xian
Mu
M
Zhang
Xiao-bin
XB
D000818:Animals; D005073:Evoked Potentials, Somatosensory; D005260:Female; D008297:Male; D000857:Olfaction Disorders / Q000209:etiology / Q000503:physiopathology; D009830:Olfactory Bulb / Q000293:injuries* / Q000503:physiopathology*; D009831:Olfactory Mucosa / Q000473:pathology / Q000503:physiopathology; D009833:Olfactory Pathways / Q000503:physiopathology; D011817:Rabbits; D011897:Random Allocation