Quantified short-term outcome of uterine artery embolization with gelatin sponge particles and lipiodol for symptomatic myoma.
OBJECTIVE
To investigate and quantify clinical outcomes and spectral Doppler analyses of uterine arteries in patients with myoma undergoing uterine artery embolization (UAE) with gelatin sponge particles and lipiodol.


METHODS
Prospective observational study.


METHODS
Tertiary medical center.


METHODS
Forty premenopausal women with symptomatic myoma.


METHODS
Uterine artery embolization with gelatin sponge particles and lipiodol.


METHODS
Hemoglobin, hematocrit, CA-125, pictorial blood loss assessment, visual analogue pain scale, questionnaire for symptoms, tumor volume, and spectral Doppler analyses of uterine arteries.


RESULTS
The mean follow-up period was 8.1 months (range, 6-12). Menstrual flow improved in 29 of 35 patients (83%) and decreased significantly by 78.4%. Menstrual pain improved in 27 of 35 patients (77%) and decreased significantly by 70%. Hematocrit and CA-125 improved significantly. The mean percentage reductions of uterine and myomal volumes were 40.2% and 54.9%, respectively. The mean peak systolic velocity of the uterine arteries decreased by 52%. The major complication rate was 2.56%. There was no correlation between tumor volume reduction and clinical outcome.


CONCLUSIONS
Uterine artery embolization with gelatin sponge particles and lipiodol had satisfactory short-term outcomes, comparable to those associated with polyvinyl alcohol particles. Quantified and semiquantified measurements provided objective assessment of clinical outcomes. Serum CA-125 might play a role in clinical follow-up. Reduction of tumor volume is not predictive of UAE efficacy.
Huang
Li-Ying
LY
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Cheng
Yu-Fan
YF
Chang
Hsueh-Wen
HW
Chang
Shiuh-Young
SY
Kung
Fu-Tsai
FT
Liang
Hsi-Mi
HM
Huang
Kuan-Hui
KH
D000328:Adult; D018394:CA-125 Antigen / Q000097:blood; D004621:Embolization, Therapeutic; D005260:Female; D005780:Gelatin; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007459:Iodized Oil / Q000008:administration & dosage*; D007889:Leiomyoma / Q000628:therapy*; D008875:Middle Aged; D011142:Polyvinyl Alcohol / Q000008:administration & dosage; D011446:Prospective Studies; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000628:therapy*
D018394:CA-125 Antigen; D006454:Hemoglobins; D007459:Iodized Oil; D005780:Gelatin; D011142:Polyvinyl Alcohol