title: Prediction of primary structure deamidation rates of asparaginyl and glutaminyl peptides through steric and catalytic effects.
abstract: The primary sequence dependence of deamidation has been quantitatively explained on the basis of a simple steric and catalytic model. Application to the known deamidation rates of peptides produces a table of coefficients that permits calculation of the known deamidation rates and prediction of deamidation rates for peptide sequences that have not yet been measured. This work permits a better understanding of deamidation, provides a prediction procedure for protein engineering, and facilitates improved computation of peptide and protein primary, secondary, tertiary, and quaternary structure deamidation rates.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. noahr@its.caltech.edu
authors.forename: N E
authors.initials: NE
authors.lastname: Robinson
authors.forename: A B
authors.initials: AB
authors.lastname: Robinson
mesh_terms: D000577:Amides / Q000737:chemistry*; D000595:Amino Acid Sequence; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D009842:Oligopeptides