Molecular mechanisms of E2F-dependent activation and pRB-mediated repression.
Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle.
Frolov
Maxim V
MV
Massachusetts General Hospital Cancer Center, Bldg 149, 13th Street, Charlestown, MA 02129, USA.
Dyson
Nicholas J
NJ
D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D050684:E2F Transcription Factors; D020868:Gene Silencing; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D006801:Humans; D012097:Repressor Proteins / Q000378:metabolism*; D016160:Retinoblastoma Protein / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000145:classification / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D014157:Transcription Factors; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases