title: Progression of arteriovenous bypass restenosis in mice exposed to a 50 Hz magnetic field.
abstract: The controversy over whether magnetic fields (MF) produced by electrical wiring and appliances contribute to diseases such as cancer has been debated in the literature for more than 2 decades. These extremely low frequency fields at 50 or 60 Hz are omnipresent in the industrialized world and have been linked to various forms of cancer by epidemiological studies. Little has been published investigating any possible role of MF and cardiovascular disease, and this is the first study looking specifically at the effect of exposure to high-intensity MF on the development and progression of restenosis. A mouse arteriovenous bypass model was used, and mice were exposed to MF for periods of 1, 2, or 3 weeks. Neointima formation, infiltration of mononuclear cells, and heat shock protein 60 expression were all studied at the conclusion of the exposure regimen. Animals exposed to the MF for 1 week showed significantly smaller neointima formation compared with control mice exposed to a null field, although this difference was not observed in mice exposed for 2 or 3 weeks. No difference was found between mice exposed to MF and controls in any of the other parameters investigated.
authors.affiliation: Institute of Pathophysiology, Medical School, University of Innsbruck, Fritz-Pregl Strasse 3, A-6020 Innsbruck, Austria.
authors.forename: Blair
authors.initials: B
authors.lastname: Henderson
authors.forename: Andrea
authors.initials: A
authors.lastname: Tagwerker
authors.forename: Christina
authors.initials: C
authors.lastname: Mayrl
authors.forename: Gerald
authors.initials: G
authors.lastname: Pfister
authors.forename: Günther
authors.initials: G
authors.lastname: Boeck
authors.forename: Hanno
authors.initials: H
authors.lastname: Ulmer
authors.forename: Hermann
authors.initials: H
authors.lastname: Dietrich
authors.forename: Georg
authors.initials: G
authors.lastname: Wick
mesh_terms: D000818:Animals; D002339:Carotid Arteries / Q000601:surgery*; D018834:Chaperonin 60 / Q000378:metabolism; D055590:Electromagnetic Phenomena; D005260:Female; D006083:Graft Occlusion, Vascular / Q000209:etiology*; D007150:Immunohistochemistry; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D013601:T-Lymphocytes / Q000378:metabolism; D014684:Venae Cavae / Q000601:surgery*
chemical_list: D018834:Chaperonin 60