Solid lipid nanoparticles for parenteral drug delivery.
This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as "solid lipid nanoparticles" (SLN), "nanostructured lipid carriers" (NLC) and "lipid drug conjugate" (LDC) nanoparticles are introduced and structural differences are pointed out. Different production methods including the suitability for large scale production are described. Stability issues and drug incorporation mechanisms into the particles are discussed. In the second part, the biological activity of parenterally applied SLN and biopharmaceutical aspects such as pharmacokinetic profiles as well as toxicity aspects are reviewed.
Wissing
S A
SA
DDS, Drug Delivery Services, GmbH, Kronskamp 11, 24119 Kronshagen, Germany.
Kayser
O
O
Müller
R H
RH
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D005079:Excipients / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008055:Lipids / Q000009:adverse effects / Q000737:chemistry* / Q000493:pharmacokinetics; D036103:Nanotechnology; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism
D004337:Drug Carriers; D005079:Excipients; D008055:Lipids; D004364:Pharmaceutical Preparations