[Effect of rosiglitazone on ovulation induction in women with polycystic ovary syndrome].
OBJECTIVE
To investigate the effect of rosiglitazone on ovulation induction in women with polycystic ovary syndrome (PCOS).


METHODS
Ninety-six PCOS women with insulin resistance (IR) were randomly divided into three groups. Group A (28 cases) received clomiphene citrate (CC) alone. Group B (32 cases) received rosiglitazone alone. And group C (36 cases) received CC and rosiglitazone in combination. All were treated for three menstrual cycles. Homeostasis model assessment insulin resistance (HOMA IR) and ovulation before and after treatment were compared among the 3 groups.


RESULTS
After the treatment, HOMA IR in group B and C decreased from 1.2 +/- 0.6 to 0.6 +/- 0.2 and from 1.1 +/- 0.5 to 0.6 +/- 0.4, respectively (P < 0.05). Success rate of ovulation after treatment in group C (80%) was higher than that in group A (59%) and group B (35%, P < 0.05).


CONCLUSIONS
Rosiglitazone therapy improves insulin sensitivity and ovulation induction.
Zhang
Cui-lian
CL
The Reproductive Institute of Henan Province People's Hospital, Zhengzhou 450003, China.
Gao
Hang-yun
HY
Zhao
Zhi-gang
ZG
Jia
Ping
P
D000328:Adult; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology* / Q000627:therapeutic use; D016896:Treatment Outcome
D007004:Hypoglycemic Agents; D007328:Insulin; D045162:Thiazolidinediones; D000077154:Rosiglitazone