[Screening for inhibitors of tumor invasion into basement membranes].
During the metastatic cascade, a tumor cell passes through several connective tissue barriers that consist of various adhesive molecules, such as fibronectin, laminin, collagens, and other glucoproteins and proteoglycans. Tumor invasion is a complex process involving cell adhesion, motility (migration), and the degradation of tissue barriers caused by the different proteases secreted by tumor cells. Therefore, understanding the invasion mechanism and the control mechanisms of the invasive properties of tumor cells may help in the development of anti-metastatic and anti-invasive therapies. We focused our attention on the functional molecules involved in the invasive process as targets to control tumor metastasis, and screened the inhibitors of tumor invasion into basement membranes.
Saiki
Ikuo
I
Division of Pathogenic Biochemistry, Department of Bioscience, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
D000818:Animals; D001485:Basement Membrane / Q000473:pathology*; D001599:Berberine / Q000494:pharmacology; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000473:pathology; D002465:Cell Movement / Q000502:physiology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D051379:Mice; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D012503:Saponins / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D012503:Saponins; D001599:Berberine; D000077146:Irinotecan; D002166:Camptothecin