Heart induction: embryology to cardiomyocyte regeneration.
Developmental biologists have uncovered many of the signaling proteins that are required to recruit early embryonic cells to the myocardial lineage. A detailed understanding of their function should provide insights into the difficult task of inducing embryonic stem cells to develop cardiomyocyte precursors for cell-based therapies. These proteins may also prove to be useful to stimulate progenitor cells to differentiate into cardiomyocytes within the damaged heart.
Foley
Ann
A
Ann Foley and Mark Mercola are at the Stem Cell and Regeneration Program, The Burnham Institute, La Jolla, California, USA.
Mercola
Mark
M
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D003598:Cytoskeletal Proteins / Q000502:physiology; D004627:Embryonic Induction / Q000502:physiology; D004815:Epidermal Growth Factor / Q000502:physiology; D058851:GPI-Linked Proteins; D006321:Heart / Q000196:embryology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology*; D009363:Neoplasm Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D051153:Wnt Proteins; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D058851:GPI-Linked Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C070636:TDGF1 protein, human; D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin; D004815:Epidermal Growth Factor