[Extramembranous glomerulonephritis and myelodysplastic syndrome].
Membranous glomerulonephritis (MGN) is the main cause of nephrotic syndrome in adults and is usually idiopathic. We report a case of nephrotic MGN associated with a myelodysplastic syndrome (MDS) in a 43 year old man. The initial treatment consisted of oral corticosteroids (1 mg/kg/day). Within 3 months proteinuria decreased from 22.4 g/day to 3.96 g/day and the blood cell count was normalized. Renal biopsy disclosed type I MGN. Ponticelli's protocol was started with a favorable effect: negative proteinuria, normal blood cell count and normal bone marrow cellularity. The association between MGN and MDS is quite rate. The possible links between the two conditions are reviewed.
Doukkali
O
O
Service de néphrologie-hémodialyse, CHU Ibn Rochd, Casablanca. oumnia_df@yahoo.fr
Tarrass
F
F
Medkouri
G
G
Fatihi
E
E
Ramdani
B
B
Zaid
D
D
Azzouzi
S
S
Sqalli
S
S
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D015433:Glomerulonephritis, Membranous / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000188:drug therapy; D009404:Nephrotic Syndrome / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D000305:Adrenal Cortex Hormones; D000806:Angiotensin-Converting Enzyme Inhibitors; D014409:Tumor Necrosis Factor-alpha