title: Fibrin glue is useful in preventing early dialysate leakage in children on chronic peritoneal dialysis.
abstract: OBJECTIVE
  To assess if application of fibrin glue sealant to the peritoneal cuff suture is useful in the prevention of early dialysate leakage in children with end-stage renal disease on chronic peritoneal dialysis (CPD).
  
  
  METHODS
  Single-center, open-label, prospective randomized study.
  
  
  METHODS
  University Pediatric Hospital.
  
  
  METHODS
  52 catheters were implanted in 45 children (mean age 6.2 +/- 4.5 years). Catheters were randomly assigned to either the control group or the sealant group. In the latter group, 1 mL of fibrin glue sealant was applied to the peritoneal cuff suture. 18 catheters were used for the first time within 5 days after implantation (early-used catheters). Leakage, exit-site or tunnel infection, peritonitis, and adverse secondary effects were evaluated during the initial 60 days after implantation.
  
  
  RESULTS
  No adverse secondary effects were seen after the application of the fibrin glue sealant. The incidence of exit/tunnel infection and peritonitis was similar in the two groups. The incidence of leakage was significantly lower in the sealant group (p < 0.02). In the early-used catheters, leakage was detected in 9% of the catheters in the sealant group and in 57% of the control group (p < 0.05).
  
  
  CONCLUSIONS
  The application of 1 mL of fibrin glue to the peritoneal cuff suture prevented early dialysate leakage without secondary adverse effects in children on CPD.
authors.affiliation: Nephrology Department, J.P Garrahan University Pediatric Hospital, Buenos Aires, Argentina. ersojo@intramed.net
authors.forename: Ernesto T
authors.initials: ET
authors.lastname: Sojo
authors.forename: Monica D
authors.initials: MD
authors.lastname: Grosman
authors.forename: Marta L
authors.initials: ML
authors.lastname: Monteverde
authors.forename: Marcela M
authors.initials: MM
authors.lastname: Bailez
authors.forename: Norma
authors.initials: N
authors.lastname: Delgado
mesh_terms: D002404:Catheterization / Q000379:methods*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004868:Equipment Failure; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology / Q000517:prevention & control*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D010530:Peritoneal Dialysis; D011446:Prospective Studies; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives