Good outcome for infant of mother treated with chemotherapy for ewing sarcoma at 25 to 30 weeks' gestation.
There have been only three previous reports of women with Ewing sarcoma who received chemotherapy while pregnant. A 17-year-old woman with Ewing sarcoma was treated with a combination of doxorubicin (Adriamycin) and ifosfamide during the 25th to 30th week of gestation, and the baby was delivered at the 32nd week. The baby was developing normally at follow-up at 8 months of age. This case report supports the idea that in this situation, the pregnancy can be continued to await fetal growth, and second-trimester chemotherapy may not have a deleterious effect on the fetus.
Nakajima
Wako
W
Department of Pediatrics, Akita University School of Medicine, Akita, Japan. wako@ped.med.akita-u.ac.jp
Ishida
Akira
A
Takahashi
Maya
M
Hirayama
Masashi
M
Washino
Noriaki
N
Ogawa
Masaki
M
Takahashi
Shu
S
Okada
Kyoji
K
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D016896:Treatment Outcome
D004317:Doxorubicin; D007069:Ifosfamide