title: Resolution of macroprolactinoma-induced symptomatic hydrocephalus following cabergoline therapy.
abstract: A 71-year-old man was referred because of memory loss. Magnetic resonance imaging showed a pituitary macroadenoma associated with hydrocephalus. Marked hyperprolactinaemia was present. After 2 months of cabergoline therapy, magnetic resonance imaging showed tumour shrinkage with resolution of the hydrocephalus. We report, for the first time, the adequate and rapid clinical response of a macroprolactinoma-induced symptomatic hydrocephalus in an elderly man to a low and once-a-week dose of cabergoline therapy. Medical therapy with this dopamine agonist in this particular patient was so effective that ventriculo-peritoneal shunting could be avoided.
authors.affiliation: Departments of Endocrinology and Neurology, Hospital General, Segovia, Spain. piglesias@hgse.sacyl.es
authors.forename: Pedro
authors.initials: P
authors.lastname: Iglesias
authors.forename: Lucía Pérez
authors.initials: LP
authors.lastname: Macho
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Díez
mesh_terms: D000236:Adenoma / Q000150:complications; D000368:Aged; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004873:Ergolines / Q000627:therapeutic use*; D006801:Humans; D006849:Hydrocephalus / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications; D015175:Prolactinoma / Q000150:complications* / Q000209:etiology
chemical_list: D018491:Dopamine Agonists; D004873:Ergolines; D000077465:Cabergoline