Hereditary and acquired angioedema: experience with patients in Puerto Rico.
Hereditary (HAE) and acquired (AAE) angioedema are vascular reactions involving the sub mucosal tissues, representing localized edema caused by dilatation and increased permeability of the capillaries. HAE and AAE are clinical disorders characterized by angioedema that require prompt differentiation from other causes of angioedema in order to receive the most pertinent and effective therapeutic interventions. The aim of this report is to describe the clinical characteristics of patients with both HAE and AAE identified and followed at the Immunology Clinic of the University Hospital at the Puerto Rico Medical Center, their response and side effects to danazol therapy and their comparison with other series of similar patients reported in the literature. Overall, the patients in this sample presented a similar clinical profile compared to other reported series in the literature.
Santaella
María L
ML
Department of Medicine, School of Medicine, Medical Sciences Campus, University of Puerto Rico, PO Box 365067, San Juan, P.R. 00936-5067.
Martinó
Alejandro
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000799:Angioedema / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D002648:Child; D003172:Complement C1 / Q000032:analysis; D015922:Complement C1q / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000032:analysis; D003613:Danazol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D003172:Complement C1; D003181:Complement C4; D003169:Complement Inactivator Proteins; D004965:Estrogen Antagonists; D015922:Complement C1q; D003613:Danazol