Pattern-based detection of different proteins using an array of fluorescent protein surface receptors.
A small library of porphyrin derivatives whose fluorescence emission changes on binding to protein surfaces has been developed as a protein "fingerprinting" array. When incubated with different proteins, the array yields a characteristic response, specific for every protein analyte. At the same time, this design allows for the rapid screening of the porphyrin library for the identification of high affinity protein surface ligands.
Baldini
Laura
L
Department of Chemistry, Yale University, P.O. Box 208107, 225 Prospect Street, New Haven, Connecticut 06520-8107, USA.
Wilson
Andrew J
AJ
Hong
Jason
J
Hamilton
Andrew D
AD
D005453:Fluorescence; D015394:Molecular Structure; D040081:Protein Array Analysis / Q000379:methods*; D011485:Protein Binding; D011506:Proteins / Q000032:analysis* / Q000737:chemistry
D011506:Proteins