A visualisation concept of dynamic signalling networks.
Cellular processes and pathways are typically delineated in arrow diagrams to depict the relationship between the individual genes or proteins. These simplifications neglect the complexity and non-linearity of cellular regulatory networks. In this review, a three-dimensional (3D) visualisation model is presented that can be helpful in understanding the non-linear behaviour and limited predictability of regulatory networks, as well as their organisation, stability, attractor states, and evolution. A better understanding of the current views of large, complex scale-free networks can assist in planning and interpretation of high throughput microarray experiments.
Jenster
Guido
G
Department of Urology, Josephine Nefkens Institute, Be362a, Erasmus MC, 3000 DR Rotterdam, The Netherlands. g,jenster@erasmusmc.nl
D005075:Biological Evolution; D002468:Cell Physiological Phenomena; D003626:Data Display; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction