Adsorptive stripping voltammetric behaviour of azomethine group in pyrimidine-containing drugs.
The stripping voltammetric behaviour of buspirone hydrochloride (BUS) and piribedil (PIR), as models of pyrimidine-containing compounds, was studied using a hanging mercury drop electrode (HMDE). A sensitive adsorptive stripping voltammetric method for determination of such drugs is described. The voltammetric peaks were obtained at -1.23 and -1.22 V for BUS and PIR. respectively, which correspond to the reduction of the azomethine group of pyrimidine ring in Britton-Robinson buffer (pH 7). Factors such as pH of supporting electrolyte, accumulation potential and time and instrumental parameters were optimized. Calibration plots and regression data validation, accuracy, precision, limits of detection, limits of quantification, and other aspects of analytical merit are presented. The applicability of the method was evaluated through determination of BUS and PIR in tablet dosage forms. A preliminary study of the analysis of plasma samples, spiked with the investigated drug, after a simple extraction procedure is described.
Sabry
Suzy M
SM
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. suzymsabry@hotmail.com
Barary
Magda H
MH
Abdel-Hay
Mohamed H
MH
Belal
Tarek S
TS
D000327:Adsorption; D001391:Azo Compounds / Q000032:analysis* / Q000493:pharmacokinetics*; D002065:Buspirone / Q000032:analysis / Q000493:pharmacokinetics; D004563:Electrochemistry; D009282:Naphthalenesulfonates / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000378:metabolism; D010891:Piribedil / Q000032:analysis / Q000493:pharmacokinetics; D011743:Pyrimidines / Q000032:analysis* / Q000493:pharmacokinetics*; D013882:Thiosemicarbazones / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics
D001391:Azo Compounds; D009282:Naphthalenesulfonates; D004364:Pharmaceutical Preparations; D011743:Pyrimidines; D013882:Thiosemicarbazones; C097966:azomethine H; D010891:Piribedil; D002065:Buspirone