Use of fluorine in the medicinal chemistry and chemical biology of bioactive compounds--a case study on fluorinated taxane anticancer agents.
Ojima
Iwao
I
Institute of Chemical Biology and Drug Discovery and Department of Chemistry, State University of New York, Stony Brook, NY 11794-3400, USA. iojima@notes.cc.sunysb.edu
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D000077143:Docetaxel; D005461:Fluorine / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D017239:Paclitaxel / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D005461:Fluorine; D017239:Paclitaxel