Validation of the i-STAT handheld activated clotting time for use with bivalirudin.
Bivalirudin is being used more frequently as an anticoagulant in the cardiac catheterization laboratory. Newer devices, used to measure activated clotting time (ACT), have not been thoroughly tested for use with bivalirudin. One such device, the i-STAT ACT, measures the generation of activated thrombin to determine the level of anticoagulation. Our study demonstrated a high level of agreement between the i-STAT ACT and the Hemochron ACT in patients anticoagulated with bivalirudin. In addition, the i-STAT was shown to have an extremely high degree of reproducibility.
Schussler
Jeffrey M
JM
Department of Cardiology, Baylor University Medical Center, 621 N. Hall Street, Suite 500, Dallas, TX 75226, USA. JeffreSc@baylorhealth.edu
Lander
Stuart R
SR
Wissinger
Laurie A
LA
Anwar
Azam
A
Donsky
Michael S
MS
Johnson
Kenneth B
KB
Vallabhan
Ravi C
RC
Wischmeyer
Jason B
JB
D000925:Anticoagulants / Q000097:blood*; D001780:Blood Coagulation Tests / Q000295:instrumentation*; D006328:Cardiac Catheterization / Q000379:methods; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D010446:Peptide Fragments / Q000627:therapeutic use*; D019095:Point-of-Care Systems / Q000592:standards*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D015203:Reproducibility of Results
D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin