title: Sirolimus-induced hyperlipidaemia in liver transplant recipients is not dose-dependent.
abstract: BACKGROUND
  Sirolimus is a potent immunosuppressive medication that acts by inhibiting T-cell proliferation. It has been used in kidney transplantation because of its lack of nephrotoxicity. It is now being investigated in liver transplantation, but there are concerns about safety and long-term side effects such as dyslipidaemia. Hypertriglyceridaemia is a common adverse event seen with sirolimus use, and often does not respond to dose reduction or anti-lipemic drugs.
  
  
  METHODS
  We report six patients who have developed significant hyperlipidaemia while receiving sirolimus, in spite of therapeutic trough levels.
  
  
  CONCLUSIONS
  All six patients showed either resolution or improvement in lipid levels with discontinuation of sirolimus.
authors.affiliation: Center for Liver Diseases and Transplantation, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Firpi
authors.forename: T T
authors.initials: TT
authors.lastname: Tran
authors.forename: P
authors.initials: P
authors.lastname: Flores
authors.forename: N
authors.initials: N
authors.lastname: Nissen
authors.forename: S
authors.initials: S
authors.lastname: Colquhoun
authors.forename: C
authors.initials: C
authors.lastname: Shackleton
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: J M
authors.initials: JM
authors.lastname: Vierling
authors.forename: F F
authors.initials: FF
authors.lastname: Poordad
mesh_terms: D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D020123:Sirolimus / Q000009:adverse effects*; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus