Synthesis, structural characterization, and antitumor activity of palladium(II) complexes containing a sugar unit.
Six palladium(II) complexes as cisplatin derivatives with a sugar unit (D-glucose, D-galactose, D-mannose, D-xylose, and maltose) have been prepared. The structural features of the complexes have been characterized by NMR spectroscopy, elemental analysis, mass spectroscopy, and X-ray crystallography. The complexes have been tested for in vivo cytotoxicity against P388 cells implanted in mice. All of Pd compounds are apparently nontoxic. A T/C value of 120% was obtained for maltose derivative at the dose of 400 mg/kg, which indicates that the compound may be endowed with antitumor activity.
Brudziñska
Izabela
I
Division of Material Science, Graduate School of Humanities and Sciences, Nara Women's University, Nara 630-8506, Japan.
Mikata
Yuji
Y
Obata
Makoto
M
Ohtsuki
Chikara
C
Yano
Shigenobu
S
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002241:Carbohydrates; D045744:Cell Line, Tumor; D002945:Cisplatin; D051379:Mice; D015394:Molecular Structure; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D010165:Palladium; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002241:Carbohydrates; D009942:Organometallic Compounds; D010165:Palladium; D002945:Cisplatin