Paraneoplastic "stiff person syndrome" with metastatic adenocarcinoma and anti-Ri antibodies.
A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.
McCabe
D J H
DJ
University Department of Clinical Neurosciences, Royal Free and University College, Medical School, London, UK. d.mccabe@ion.ucl.ac.uk
Turner
N C
NC
Chao
D
D
Leff
A
A
Gregson
N A
NA
Womersley
H J
HJ
Mak
I
I
Perkin
G D
GD
Schapira
A H V
AH
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000276:immunology* / Q000556:secondary; D000328:Adult; D002272:Carcinoembryonic Antigen / Q000097:blood; D003680:Deglutition Disorders / Q000209:etiology; D004401:Dysarthria / Q000209:etiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000276:immunology*; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D009474:Neurons / Q000276:immunology; D010166:Palliative Care; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000276:immunology*; D011877:Radionuclide Imaging; D013116:Spinal Cord / Q000276:immunology; D016750:Stiff-Person Syndrome / Q000175:diagnosis / Q000276:immunology*; D034941:Upper Extremity / Q000503:physiopathology
D002272:Carcinoembryonic Antigen; D019788:Fluorodeoxyglucose F18