Drug-induced cardiac toxicity: emphasizing the role of electrocardiography in clinical research and drug development.
This review describes the role of electrocardiography in clinical research and drug development, and addresses its utility in defining cardiac toxicity from noncardiac investigational drugs. Principles for designing electrocardiographic monitoring for cardiac safety in clinical trials are also reviewed.
Gussak
Ihor
I
igussak@ert.com
Litwin
Jeffrey
J
Kleiman
Robert
R
Grisanti
Scott
S
Morganroth
Joel
J
D002986:Clinical Trials as Topic; D004341:Drug Evaluation / Q000331:legislation & jurisprudence / Q000592:standards* / Q000639:trends; D015507:Drugs, Investigational / Q000009:adverse effects*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006331:Heart Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control; D006801:Humans; D012106:Research / Q000331:legislation & jurisprudence / Q000592:standards / Q000639:trends
D015507:Drugs, Investigational