New lignans and cytotoxic constituents from Wikstroemia lanceolata.
Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known sesquiterpenoid, 1alpha,7alpha,10alpha H-guaia-4,11-dien-3-one ( 24) were revised by 2D NMR techniques. Among the isolates, three compounds, (+)-hinokinin ( 6), 2,6-dimethoxy- p-benzoquinone ( 17), and 1alpha,7alpha,10alpha H-guaia-4,11-dien-3-one ( 24) exhibited effective cytotoxicities (ED50 values < 4.0 microg mL-1) against P-388 and HT-29 tumor cell lines.
Lin
Ru-Wei
RW
Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan, Republic of China.
Tsai
Ian-Lih
IL
Duh
Chang-Yih
CY
Lee
Kuo-Hsiung
KH
Chen
Ih-Sheng
IS
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D019073:HT29 Cells / Q000187:drug effects; D006801:Humans; D017705:Lignans / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D018547:Plant Stems; D032365:Wikstroemia
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D010936:Plant Extracts