title: Regulation of apoptosis by viruses that infect insects.
abstract: Orthobunyviruses and alphaviruses cause encephalitis, neuronal apoptosis and mortality in mammals, but fail to kill the mosquitoes that transmit these viruses. Therefore, host cell factors, as well as viral factors, regulate the outcome of infection. Drosophila Reaper is a pro-death factor in the Drosophila nervous system during development but homologues were not previously known to exist outside flies. Recent discovery of a Reaper protein encoded by orthobunyaviruses provides interesting insight into the mechanisms by which viruses modulate the death pathway in both vertebrate and invertebrate hosts.
authors.affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Irusta
authors.forename: E
authors.initials: E
authors.lastname: Lamos
authors.forename: H L
authors.initials: HL
authors.lastname: Galonek
authors.forename: M A
authors.initials: MA
authors.lastname: Vander Maten
authors.forename: M C H
authors.initials: MC
authors.lastname: Boersma
authors.forename: Y B
authors.initials: YB
authors.lastname: Chen
authors.forename: J M
authors.initials: JM
authors.lastname: Hardwick
mesh_terms: D000524:Alphavirus / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002043:Bunyaviridae / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*; D061945:Caspase Inhibitors; D009033:Culicidae / Q000821:virology; D004330:Drosophila / Q000821:virology; D029721:Drosophila Proteins / Q000502:physiology; D007313:Insecta / Q000821:virology*; D008322:Mammals; D008928:Mitochondria / Q000502:physiology; D010539:Permeability; D014779:Virus Replication / Q000502:physiology*
chemical_list: D061945:Caspase Inhibitors; D029721:Drosophila Proteins; C086973:rpr protein, Drosophila