title: Comparison of solute clearance in three modes of continuous renal replacement therapy.
abstract: OBJECTIVE
  To compare the clearances of low molecular weight molecules using three modalities of continuous renal replacement therapy (CRRT) at the low blood flow rates typically used in pediatric patients.
  
  
  METHODS
  A controlled, in vitro laboratory study.
  
  
  METHODS
  Research laboratory of a health sciences university.
  
  
  METHODS
  AN69 dialysis hemofilter.
  
  
  METHODS
  CRRT was performed using a 0.6 m(2) AN69 hemofilter. Human whole blood and plasma were combined to achieve a hematocrit of approximately 30%. Urea and creatinine were added to obtain concentrations of approximately 54 mmol/L of blood urea nitrogen and 1770 micromol/L of creatinine. Clearance data for urea and creatinine at a blood flow rate of 60 mL/min were generated using predilution continuous venovenous hemofiltration (CVVH), postdilution CVVH, and continuous venovenous hemodialysis (CVVHD).
  
  
  RESULTS
  Clearance of all three modalities was compared at a replacement solution (CVVH) or dialysate (CVVHD) flow rate of 16.7% of the blood flow rate. Both postdilution CVVH and CVVHD had a urea clearance of 11.3 mL/min, which was 15% greater than the 9.8 mL/min urea clearance of predilution CVVH (p <.005). Creatinine clearance with postdilution CVVH (10.7 mL/min) was 15% greater than the 9.0 mL/min clearance produced by predilution CVVH (p < 0.01). Predilution CVVH and CVVHD were compared at a flow rate of either replacement solution (CVVH) or dialysate (CVVHD) of 33% and 50% of the blood flow rate. Postdilution CVVH was not performed at high ultrafiltration rates due to the potential problem of hemoconcentration. CVVHD clearances of urea and creatinine were statistically superior to predilution CVVH at both flow rates.
  
  
  CONCLUSIONS
  CVVHD was superior to predilution CVVH for clearance of urea and creatinine. Postdilution CVVH and CVVHD gave nearly equivalent clearances. At the low blood flow rates used in pediatric patients, which raise concerns about high ultrafiltration during postdilution CVVH causing excessive hemoconcentration and filter clotting, CVVHD appears to be the optimal modality for maximizing clearance of small solutes during CRRT.
authors.affiliation: Division of Pediatric Critical Care and Division of Pediatric Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
authors.forename: Daiva
authors.initials: D
authors.lastname: Parakininkas
authors.forename: Larry A
authors.initials: LA
authors.lastname: Greenbaum
mesh_terms: D001783:Blood Flow Velocity; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood*; D006400:Hematocrit; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D008970:Molecular Weight; D014508:Urea / Q000097:blood*
chemical_list: D014508:Urea; D003404:Creatinine