Orthologous gene-expression profiling in multi-species models: search for candidate genes.
Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.
Grigoryev
Dmitry N
DN
Center for Translational Respiratory Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, East Monument Street, Baltimore, MD 21287, USA.
Ma
Shwu-Fan
SF
Irizarry
Rafael A
RA
Ye
Shui Qing
SQ
Quackenbush
John
J
Garcia
Joe G N
JG
D000818:Animals; D002460:Cell Line; D004195:Disease Models, Animal; D004285:Dogs; D004727:Endothelium / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods* / Q000706:statistics & numerical data; D005796:Genes / Q000235:genetics; D006801:Humans; D008168:Lung / Q000737:chemistry / Q000378:metabolism; D008171:Lung Diseases / Q000235:genetics; D051379:Mice; D008957:Models, Genetic; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods* / Q000706:statistics & numerical data; D051381:Rats; D013045:Species Specificity