C-reactive protein plasma levels but not factor VII activity predict clinical outcome in patients undergoing elective coronary intervention.
BACKGROUND
Both vascular inflammation as determined by C-reactive protein (CRP) and extrinsic coagulation as measured by factor VII activity (F VII) may predict clinical restenosis rate in patients with stable angina pectoris undergoing elective percutaneous coronary intervention (PCI).


OBJECTIVE
The primary objective of this study was to investigate the associations between baseline CRP levels, F VII activity, and restenosis rate after elective PCI in a 6-month follow-up period.


METHODS
This prospective study included 81 patients aged > or = 19 years undergoing PCI for angiographically significant (> or = 70%) stenosis, with or without stenting, and 49 controls. Factor VII activity and CRP were measured in samples collected at angiography and 16-24 h post procedure after overnight fast. Successful PCI was defined as final diameter of < 50% with TIMI 3 flow and no complication within 1 h. After 6 months all patients who had undergone PCI were evaluated via a standardized questionnaire. Clinical restenosis was defined as the occurrence of a major adverse coronary events (MACE), within the follow-up period.


RESULTS
Diagnostic angiography led to a significant increase in CRP levels after 16-20 h in patients with discrete CAD (n = 22) but not in patients without any signs of coronary atherosclerosis (n = 27). During a 6-month follow-up after PCI, 17 of 81 (21%) patients developed MACE. Tertiles of CRP levels independently predicted clinical restenosis, as it developed in 33.3% of patients with the highest CRP levels (0.7-4.8 mg/dl), in 16.6% of patients with second tertile CRP levels (0.23-0.69 mg/dl), and in 7.4% of patients with lowest tertile CRP levels (0.0-0.22 mg/dl). There was a significant difference in the restenosis rate between patients from the first and the third tertiles (p = 0.018). Successful PCI was associated with a significant decrease of mean CRP levels after 6 months, whereas PCI in patients suffering from MACE led to no change in CRP levels. There was no association between factor VII activity and clinical outcome after PCI, and F VII activity did not change over a 6-month period.


CONCLUSIONS
In patients with stable angina pectoris undergoing elective PCI, increased preprocedural and 6-month follow-up CRP plasma levels are associated with clinical restenosis. Factor VII plasma activity lacks such correlations.
Grander
Wilhelm
W
Department of Internal Medicine, Division of Cardiology, University Hospital, Leopold-Franzens-University, Innsbruck, Austria. wilhelm.grander@bkh-hall.or.at
Dichtl
Wolfgang
W
Prokop
Wolfgang
W
Roithinger
Franz X
FX
Moes
Nicolas
N
Friedrich
Guy
G
Weidinger
Franz
F
Pachinger
Otmar
O
D000328:Adult; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology; D005167:Factor VII / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors
D005167:Factor VII; D002097:C-Reactive Protein