The baroreflex is counteracted by autoregulation, thereby preventing circulatory instability.
The aims of this study were (a) to apply in the animal with intact baroreflex a two-point method for estimation of overall, effective open-loop gain, G0e, which results from the combined action of baroregulation and total systemic autoregulation on peripheral resistance; (b) to predict specific baroreflex gain by correcting the effective gain for the autoregulation gain; and (c) to discuss why the effective gain is usually as low as 1-2 units. G0e was estimated from two measurements of both cardiac output, Q, and mean systemic arterial pressure, P: one in the reference state (set-point) and the other in a steady-state reached 1-3 min after a small cardiac output perturbation. In anaesthetized cats and dogs a cardiac output perturbation was accomplished by partial occlusion of the inferior vena cava and by cardiac pacing, respectively. Average (+/-s.e.m.) estimates of G0e were 1.4 +/- 0.2 (n= 8) in the cat and 1.5 +/- 0.4 (n= 5) in the dog. The specific baroreflex open-loop gain, G0b, found after correction for total systemic autoregulation, was 3.3 +/- 0.4 in the cat and 2.8 +/- 0.8 in the dog. A model-based analysis showed that, with G0e as low as 1.4, the closed-loop response of P to a stepwise perturbation in Q results in damped oscillations that disappear in about 1 min. The amplitude and duration of these oscillations, which have a frequency of about 0.1 Hz, increase with increasing G0e and cause instability when G0e is about 3. We conclude that autoregulation reduces the effectiveness of baroreflex gain by about 55%, thereby preventing instability of blood pressure response.
Burattini
Roberto
R
Department of Electromagnetism and Bioengineering, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy. r.burattini@univpm.it
Borgdorff
Piet
P
Westerhof
Nico
N
D000758:Anesthesia; D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output / Q000502:physiology; D002415:Cats; D004285:Dogs; D006706:Homeostasis / Q000502:physiology*; D008955:Models, Cardiovascular; D014655:Vascular Resistance / Q000502:physiology