Bio-bar-code-based DNA detection with PCR-like sensitivity.
Novel two-component oligonucleotide-modified nanoparticle probes have been designed and used in a bio-bar-code assay with a 500 zeptomolar target DNA sensitivity limit.
Nam
Jwa-Min
JM
Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
Stoeva
Savka I
SI
Mirkin
Chad A
CA
D004247:DNA / Q000235:genetics*; D015342:DNA Probes; D006046:Gold; D008280:Magnetics; D008863:Microspheres; D036103:Nanotechnology; D021141:Nucleic Acid Amplification Techniques; D009841:Oligonucleotides / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D015342:DNA Probes; D009841:Oligonucleotides; D006046:Gold; D004247:DNA