[High performance liquid chromatography in cortisol kinetics and its kinetic parameters in patients treated with exogenous glucocorticoids].
The kinetics of cortisol was investigated in 26 healthy subjects and in 9 patients with rheumatoid arthritis induced by exogenous glucocorticosteroids. The cortisol concentration was determined in blood serum by using a high-efficiency liquid chromatography method. The cortisol kinetic parameters were found by empirically constructed formulae. An inadequate synthesis of cortisol was found in patients with rheumatoid arthritis after prednisolone administration. The results can be used for evaluating the pharmacodynamic properties of glucocorticosteroids.
Chekalin
A F
AF
Rossokhin
V F
VF
Shishkanov
S F
SF
Kazakova
M A
MA
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005938:Glucocorticoids / Q000493:pharmacokinetics*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007700:Kinetics; D008297:Male; D008775:Methylprednisolone / Q000493:pharmacokinetics; D008875:Middle Aged; D011239:Prednisolone / Q000493:pharmacokinetics
D005938:Glucocorticoids; D011239:Prednisolone; D006854:Hydrocortisone; D008775:Methylprednisolone