title: [Covert infection of severe acute respiratory syndrome in health-care professionals and its relation to the workload and the type of work].
abstract: OBJECTIVE
  To study severe acute respiratory syndrome (SARS) covert infection in health-care professionals and its relation to work intensity and type of work.
  
  
  METHODS
  Specific antibodies to SARS virus in 1 127 serum specimens from health-care professionals who had a close contact history with patients of SARS and 92 healthy persons were assayed with ELISA.
  
  
  RESULTS
  The health-care professionals consisted of 287 men and 840 women, aged 21 - 55 years (mean 34 +/- 9 years). The overall positive rate of specific IgG and IgM was 2.57% (29/1 127); the positive rates in nurses, doctors and laboratory workers, and supervisors were 3.46%, 1.41%, 2.86%, respectively. 34.5% of the infected worked in the ICU, and 65.5% in the general wards. None of them presented clinical SARS. Medical examination was also carried out for 313 people who had close contact with the 29 antibody positive health care professionals, but no clinical SARS was found.
  
  
  CONCLUSIONS
  Covert infection can be found in the health-care professionals and it showed no contagiousness. The positive rate of specific antibodies was higher in ICU where the work intensity was higher. The positive rate in nurses was higher than in doctors.
authors.affiliation: Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Nong
authors.forename: Jiang-tao
authors.initials: JT
authors.lastname: Lin
authors.forename: Zhe
authors.initials: Z
authors.lastname: Cai
authors.forename: Tong-liang
authors.initials: TL
authors.lastname: Zhou
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Gui-qin
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016358:Contact Tracing / Q000706:statistics & numerical data; D003428:Cross Infection / Q000635:transmission*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000706:statistics & numerical data*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009726:Nurses; D016273:Occupational Exposure / Q000706:statistics & numerical data; D010820:Physicians; D045473:Severe acute respiratory syndrome-related coronavirus / Q000276:immunology; D045169:Severe Acute Respiratory Syndrome / Q000635:transmission*; D016526:Workload / Q000706:statistics & numerical data
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M