HCV and associated concomitant infections at Sharkia Governorate, Egypt.
The natural history of hepatitis C virus (HCV) infection has a highly variable course. Many patients develop chronic infection, with its consequent risk of cirrhosis, liver failure and hepatocellular carcinoma. A key question is whether patients at high risk of disease progression can be distinguished from those with relatively benign disease course. The disease progression is influenced by other factors such as duration of infection, age at infection, sex, co-infection with hepatitis B virus (HBV), Epstein Bar virus (EBV), cytomegalovirus (CMV), the level of HCV viraemia and its type. Other endemic infections in the community as bilharziasis may have a role in progression of the condition to serious complications. These factors are correlated with newly proposed grades and stages of the disease. The studied (109) cases were divided into 6 groups according to the concomitant infection with HCV. The result proved that groups 1, 3 & 5 had a higher level of viraemia than other groups, and to be the high-risk groups as 56.4% and 34.6% were in G2S2 and G3S3, respectively. All cases of liver cell dysplasia and hepatocellular carcinoma in this study were seen in these groups. The conclusion showed that these factors play an important role in the progression of HCV infection. Death of the patients of this progressive condition occurs in younger age and is more due to liver failure than to HCC.
Mangoud
Amal M
AM
Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Eissa
Mostafa H
MH
Sabee
Essam I
EI
Ibrahem
Ibrahem A
IA
Ismail
Alaa
A
Morsy
Tosson A
TA
Etewa
Samia
S
Mahrous
Seham
S
Nor Edin
Essam
E
Mostafa
Yousry
Y
Abouel-Magd
Yousry
Y
Afefy
Afefy F
AF
el-Shorbagy
Eman
E
el-Sedawy
Mahmoud
M
Ragab
Hosenia
H
Hassan
Mostafa I
MI
Lakouz
Khalid
K
Abdel-Aziz
Khalid
K
Saber
Mahmoud
M
el-Hady
Gaber
G
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology; D018450:Disease Progression; D004534:Egypt / Q000453:epidemiology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012552:Schistosomiasis / Q000150:complications* / Q000453:epidemiology; D014766:Viremia / Q000453:epidemiology