title: [Electrically stimulated olfactory evoked potential in olfactory-lesioned rabbit].
abstract: OBJECTIVE
  To develop olfactory dysfunctioned animal model by injuring olfactory blub(s) and to investigate the characteristics of olfactory evoked potential.
  
  
  METHODS
  The changes of OEP in rabbits were observed at 24 h, 48 h and 1 w after olfactory bulb(s) were electrolytically injured. The pathological and ultrastructural changes of olfactory mucosa and olfactory bulb were also observed.
  
  
  RESULTS
  When unilateral olfactory bulb was damaged, N2 vanished with elongated latencies and lowered amplitudes of N1 and P1. When both olfactory bulbs were damaged, N1 and N2 were absent, only P1 could be recorded. The latency was extended obviously and the amplitude had a big change. Histopathology and ultrastructure showed that there were a lot of inflammatory cells and degenerated neurons scattered around OB 24 hours to 48 hours after injure. It was observed that the olfactory cilia had distraction perversion and colliquefaction changes.
  
  
  CONCLUSIONS
  Different degree of olfactory bulb injury caused different effect on OEPs. These changes of potential were based on the histopathology and ultrastructure.
authors.affiliation: Department of Otorhinolaryngology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China. weiyongxiang@vip.sina.com
authors.forename: Yong-xiang
authors.initials: YX
authors.lastname: Wei
authors.forename: De-min
authors.initials: DM
authors.lastname: Han
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cai
authors.lastname: Yang-Ling
authors.forename: Xiao-chao
authors.initials: XC
authors.lastname: Liu
authors.forename: Mu
authors.initials: M
authors.lastname: Xian
authors.forename: Xiao-bin
authors.initials: XB
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005073:Evoked Potentials, Somatosensory; D005260:Female; D008297:Male; D000857:Olfaction Disorders / Q000209:etiology / Q000503:physiopathology; D009830:Olfactory Bulb / Q000293:injuries* / Q000503:physiopathology*; D009831:Olfactory Mucosa / Q000473:pathology / Q000503:physiopathology; D009833:Olfactory Pathways / Q000503:physiopathology; D011817:Rabbits; D011897:Random Allocation