title: Experimental comparison of high power (80 W) potassium titanyl phosphate laser vaporization and transurethral resection of the prostate.
abstract: OBJECTIVE
  Perioperative hemorrhage is still the major complication of standard transurethral prostate resection (TURP). Potassium titanyl phosphate (KTP) laser vaporization using 80 W is a novel technique that promises instant hemostatic tissue ablation. In this ex vivo investigation we compared the hemostatic properties of the 2 procedures.
  
  
  METHODS
  Ex vivo, blood perfused porcine kidneys were used to verify the hemostatic efficacy of KTP laser vaporization and TURP-like tissue resection. Bleeding could be exactly quantified in relation to tissue ablation for the 2 techniques. In addition, specimens were examined microscopically.
  
  
  RESULTS
  KTP laser vaporization demonstrated highly significantly decreased bleeding as compared to conventional tissue resection for a standardized ablation volume of 16 cm tissue (2.1 vs 23.3 ml per minute, p <0.0001). Tissue ablation was more rapid in the resection group (20 vs 100 seconds, p <0.001). Histological examinations revealed larger coagulation zones for the KTP group compared to conventional tissue resection (0.9 vs 0.6 mm, p <0.01).
  
  
  CONCLUSIONS
  Ex vivo, 80 W KTP laser vaporization is a virtually bloodless ablative procedure, giving rise to hemostasis that is highly superior to conventional TURP-like tissue resection. However, the novel procedure is considerably more time-consuming.
authors.affiliation: Department of Urology, University Hospital Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Reich
authors.forename: Alexander
authors.initials: A
authors.lastname: Bachmann
authors.forename: Peter
authors.initials: P
authors.lastname: Schneede
authors.forename: Dirk
authors.initials: D
authors.lastname: Zaak
authors.forename: Tullio
authors.initials: T
authors.lastname: Sulser
authors.forename: Alfons
authors.initials: A
authors.lastname: Hofstetter
mesh_terms: D000818:Animals; D004560:Electricity; D006489:Hemostatic Techniques; D053685:Laser Therapy; D008297:Male; D010710:Phosphates; D011468:Prostatectomy / Q000379:methods; D013552:Swine; D014025:Titanium; D020728:Transurethral Resection of Prostate
chemical_list: D010710:Phosphates; C064806:potassium titanylphosphate; D014025:Titanium