title: Overexpression of annexin 1 in pancreatic cancer and its clinical significance.
abstract: OBJECTIVE
  To investigate the expression of annexin I in pancreatic cancer and its relationship with the clinicopathologic factors, and to evaluate its potential clinical significance.
  
  
  METHODS
  Annexin I expression was analyzed by Western blot and immunohistochemical staining in pancreatic adenocarcinoma and multi-tissue microarrays (MTAs).
  
  
  RESULTS
  Western blot analysis showed that annexin I was overexpressed in 84.6% (11/13) pancreatic ductal adenocarcinomas. Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4%(30/42) positive which was markedly increased compared with that in the tumor matched normal pancreas tissues 18.4%(7/38) (P<0.01). In the meantime, the high expression of annexin 1 was correlated with the poor differentiation of pancreatic adenocarcinoma.
  
  
  CONCLUSIONS
  Annexin 1 overexpression is a frequent biological marker and correlates with the differentiation of pancreatic cancer during tumorigenesis.
authors.affiliation: National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Bai
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Ni
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Shang-Mei
authors.initials: SM
authors.lastname: Liu
authors.forename: Hui-Xin
authors.initials: HX
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Guo
authors.forename: Lan-Ping
authors.initials: LP
authors.lastname: Zhou
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Wang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Xie
authors.forename: Yong-Fu
authors.initials: YF
authors.lastname: Shao
authors.forename: Xiao-Hang
authors.initials: XH
authors.lastname: Zhao
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000818:Animals; D017305:Annexin A1 / Q000378:metabolism*; D014408:Biomarkers, Tumor; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008875:Middle Aged; D010179:Pancreas / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D040081:Protein Array Analysis
chemical_list: D017305:Annexin A1; D014408:Biomarkers, Tumor