Serum levels of folate, vitamin B12 and homocysteine in complete hydatidiform mole.
OBJECTIVE
To investigate the association, if any, between serum concentrations of folate, vitamin B12 and homocysteine in complete hydatiform mole (CHM).


METHODS
Blood samples were taken from 37 women with CHM and 52 healthy controls in the first trimester of pregnancy. Serum was analyzed for folate, vitamin B12 and homocysteine using electrochemiluminescence and chemiluminescence assay.


RESULTS
In patients with CHM, significantly higher mean levels of serum vitamin B12 were encountered (247.21 versus 180.32 pg/mL, P=.012). Significantly lower mean levels of serum folate were found in patients with CHM as compared with controls (7.91 versus 10.72 ng/mL, P=.008). Homocysteine levels tended to be higher in patients with CHM, but the difference was not statistically significant (10.58 versus 8.79 nmol/mL, P=.104).


CONCLUSIONS
This is the first report to suggest an association between folate, vitamin B12 and CHM. Folate may play a protective role in preventing CHM.
Harma
Muge
M
Department of Gynecology and Obstetrics, Faculty of Medicine, University of Harran, Sanliurfa, Turkey. harmam@ixir.com
Harma
Mehmet
M
Kocyigit
Abdurrahim
A
Yurtseven
Seniz
S
Demir
Nurettin
N
D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006397:Hematinics / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006828:Hydatidiform Mole / Q000473:pathology*; D008163:Luminescent Measurements; D011247:Pregnancy; D014805:Vitamin B 12 / Q000097:blood*
D015415:Biomarkers; D006397:Hematinics; D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12