[Effect of Cryptoporus volvatus (Peck) Schear on leukotriene production from polymorphonuclear leukocytes in rats].
OBJECTIVE
To study action of Cryptoporus volvatus ferment substance (CVFS) on leukotriene production of polymorphonuclear leukocytes in rats.


METHODS
The level of slow reaction substance (SRS) and leukotriene B4 (LTB4) in polymorphonuclear leukocytes (PMNs) in rats in vitro were determined with bioassay and HPLC.


RESULTS
CVFS 0.9, 2.7 g.kg-1 by ig significantly inhibited SRS and LTB4 production in PMNs in rats in vivo.


CONCLUSIONS
The inhibition effect of CVFS on SRS and LTB4 release may be related to its mechanism of anti-inflammation and anti-asthma.
Jin
Sai-hong
SH
Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical College of Zhejiang University, Medical College of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xie
Qiang-min
QM
Lin
Xiao-xia
XX
Deng
Yang-mei
YM
Chen
Ji-qiang
JQ
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002469:Cell Separation; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007975:Leukotriene B4 / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D011124:Polyporaceae / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013189:SRS-A / Q000378:metabolism
D018927:Anti-Asthmatic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D013189:SRS-A; D007975:Leukotriene B4