Grafting miniature DNA binding proteins.
Miniature proteins serve as leads for biological and medicinal applications by positioning all amino acids necessary for biomolecular recognition on a compact protein structure. Protein grafting was recently used to create miniature helical proteins with high DNA binding affinity and specificity.
Pflum
Mary Kay H
MK
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D008904:Miniaturization; D017570:MyoD Protein / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D017510:Protein Folding; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism
D000596:Amino Acids; D004268:DNA-Binding Proteins; D017570:MyoD Protein; D010455:Peptides; D016601:RNA-Binding Proteins; D004247:DNA