Senile chorea treated by deep brain stimulation: a clinical, neurophysiological and functional imaging study.
We report on a patient with senile chorea, treated with deep brain stimulation of the left globus pallidus internus and subsequently the left ventralis oralis posterior nucleus of the thalamus. Deep brain field potential recordings and functional imaging using single photon emission tomography enabled us to suggest pathophysiological mechanisms for the symptoms.
Yianni
John
J
The Oxford Movement Disorder Group, Department of Neurological Surgery, The Radcliffe Infirmary, Oxford, United Kingdom.
Nandi
Dipankar
D
Bradley
Kevin
K
Soper
Nigel
N
Gregory
Ralph
R
Joint
Carole
C
Stein
John
J
Scott
Richard
R
Aziz
Tipu
T
D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D002819:Chorea / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D004576:Electromyography / Q000295:instrumentation; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018482:Muscle, Skeletal / Q000503:physiopathology; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon