title: A novel der(12)t(7;12)(p15;q24.3) in a patient with childhood T-cell acute lymphoblastic leukemia.
abstract: Approximately 35% of T-cell acute lymphoblastic leukemia (T-ALL) cases have chromosomal translocations as evaluated by conventional cytogenetic methods (G-banding). Some chromosomal translocations are associated with morphologically and immunophenotypically distinct leukemia subtypes and define patients with different clinical outcomes. Chromosomal translocations may deregulate gene expression, thus contributing to the development of neoplasia, either by placing a putative oncogene under the control of strong regulatory elements or by generating chimeric genes and oncogenic fusion proteins. We report here a novel der(12)t(7;12)(p15;q24.3) in a child with T-ALL. Cloning and characterization of the breakpoint region may contribute to the discovery of new genes that are important in T-ALL.
authors.affiliation: Laboratório de Biologia Molecular, Centro Infantil Boldrini, Rua Gabriel Porto 1270, 13083-210 Campinas, SP, Brazil.
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: de Freitas
authors.forename: Lilian de Jesus
authors.initials: Lde J
authors.lastname: Girotto Zambaldi
authors.forename: Marcela
authors.initials: M
authors.lastname: de Araujo
authors.forename: Emerson
authors.initials: E
authors.lastname: Gatti
authors.forename: Rosemary
authors.initials: R
authors.lastname: Otubo
authors.forename: Mathilde Rie
authors.initials: MR
authors.lastname: Tsuchiya
authors.forename: Eduardo Ioshiteru
authors.initials: EI
authors.lastname: Matsuda
authors.forename: Silvia Regina
authors.initials: SR
authors.lastname: Brandalise
authors.forename: José Andrés
authors.initials: JA
authors.lastname: Yunes
mesh_terms: D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic