title: Hemodynamics of intrahepatic cholangiocarcinoma: evaluation with single-level dynamic CT during hepatic arteriography.
abstract: BACKGROUND
  We determined the radiologic characteristics of intrahepatic cholangicarcinoma (ICC) on single-level dynamic computed tomography during hepatic arteriography (CTHA) and assessed the hemodynamics of the tumor.
  
  
  METHODS
  Eleven patients with pathologically confirmed ICC underwent single-level dynamic CTHA. After placing the catheter tip in the proper hepatic artery and running a 30-s continuous scan, scanning was performed every 15 or 30 s for 120 s. The change of contrast-enhancement pattern of the ICCs were interpreted retrospectively.
  
  
  RESULTS
  The pattern of enhancement was classified into two types: vascular and hypovascular. In the vascular type, the contrast enhancement gradually spread from each intratum oral artery and became mottled. It changed from a mottled and hypoattenuated pattern to an even and hyperattenuated appearance in comparison with the adjacent liver approximately 120 s after the injection of contrast agent. In the hypovascular type, the tumor was barely enhanced and remained hypoattenuated compared with the adjacent liver at 120 s after the beginning of the injection. The 11 ICCs were classified into eight vascular types and three hypovascular types. Intratumoral arteries were visualized in nine tumors: eight vascular types and one hypovascular type.
  
  
  CONCLUSIONS
  The contrast-enhancement pattern of ICC on single-level dynamic CTHA is related to the intratumoral artery.
authors.affiliation: Department of Academic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. f-miura@med.teikyo-u.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Miura
authors.forename: S
authors.initials: S
authors.lastname: Okazumi
authors.forename: W
authors.initials: W
authors.lastname: Takayama
authors.forename: T
authors.initials: T
authors.lastname: Asano
authors.forename: H
authors.initials: H
authors.lastname: Makino
authors.forename: K
authors.initials: K
authors.lastname: Shuto
authors.forename: T
authors.initials: T
authors.lastname: Ochiai
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001653:Bile Ducts, Intrahepatic / Q000000981:diagnostic imaging*; D018281:Cholangiocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006439:Hemodynamics; D006499:Hepatic Artery / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media