Clinical profile and course of cognitively normal patients evaluated in memory disorders clinics.
The authors investigated 499 patients that were found to be cognitively normal at the Alzheimer's Disease Research Centers of California between 1988 and 1999. Patients reported high rates of depression (39%) and family history of dementia (51%). Thirty-six percent returned for follow-up, and of those, 65% received a diagnosis of dementia or mild cognitive impairment. Patients evaluated at memory clinics who are considered cognitively normal may merit periodic re-evaluation.
Edwards
Emily R
ER
Department of Psychiatry, University of California, San Francisco, USA.
Lindquist
Karla
K
Yaffe
Kristine
K
D000368:Aged; D002140:California / Q000453:epidemiology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D015897:Comorbidity; D003704:Dementia / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index