Membrane traffic: GGAs sort ubiquitin.
Membrane proteins that are tagged with ubiquitin are diverted from the secretory pathway into lysosomes. New work shows that it is the GGA proteins that initiate sorting in the Golgi, and suggests that similar principles apply to multiple sorting steps.
Pelham
Hugh R B
HR
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. hp@mrc-lmb.cam.ac.uk
D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D021381:Protein Transport / Q000502:physiology; D014452:Ubiquitins / Q000378:metabolism*
D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; C407306:GGA adaptor proteins; D014452:Ubiquitins; D020727:ADP-Ribosylation Factors