Antitubercular and antiplasmodial constituents of Abrus precatorius.
A known isoflavanquinone, abruquinone B ( 1), and a new derivative, abruquinone G ( 2), were isolated from the aerial parts of Abrus precatorius. Chemical structures of these compounds were elucidated by spectral analyses. While 1 exhibited antitubercular, antiplasmodial and cytotoxic activities, compound 2 showed mild antiviral and cytotoxic activities.
Limmatvapirat
Chutima
C
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Nakorn-Pathom, Thailand. chutima@email.pharm.su.ac.th
Sirisopanaporn
Sinenart
S
Kittakoop
Prasat
P
D029912:Abrus; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects; D014709:Vero Cells / Q000187:drug effects
D000962:Antimalarials; D000995:Antitubercular Agents; D000998:Antiviral Agents; D007529:Isoflavones; D010936:Plant Extracts