The inhibitory effects of Silso-San-Gami on atherosclerosis in KHC rabbits.
Silsosangami is a dried decoction of a mixture of seven Korean herbal medicines, consisting of Typhae pollen, Pteropi faeces, Paeoniae radicis rubra, Cnidii rhizoma, Persicae semen, Carthami flos, and Curcumae tuber. The inhibitory effect of this traditional herbal medicine, Silsosangami-water extract (SSG), on the progression of the atherosclerotic diseases was examined using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein (LDL) oxidation were measured in a control group and a SSG-administrated group. In the control group, the area of atheromatous aortic plaques progressed between 4 weeks (30.43%) and 8 weeks (47.48%). This progressin of atherosclerotic disease was not observed in the SSG-treated group between 4 weeks (22.65%) and 8 weeks (23.23%). Antioxidative effects on LDL were observed in the SSG group at 12 and 14 weeks. SSG improved hypercholestrolemia in the KHC rabbits. These results suggest that SSG has inhibitory effects on the development of atheromatous plaques in spontaneous FH model rabbits. The antioxidative effects of SSG on LDL appear to be the source of the beneficial effects observed in this study.
Park
Won-Hwan
WH
Department of Biochemistry, Molecular Biology and Diagnostics, Dongguk University College of Oriental Medicine and National Research Laboratory for Glycobiology, Korean Ministry of Science and Technology, Kyungju City, Kyungbuk, South Korea.
Shin
Sang-Seub
SS
Lee
Young-Choon
YC
Kim
Cheorl-Ho
CH
D000595:Amino Acid Sequence; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001013:Aorta, Thoracic / Q000187:drug effects / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D008077:Lipoproteins, LDL / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010455:Peptides / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors; D016896:Treatment Outcome
D000975:Antioxidants; D008077:Lipoproteins, LDL; D010455:Peptides; D010936:Plant Extracts; C487854:silsosangami