title: The relationship of tonsillar hyperplasia and asthma in a group of asthmatic children.
abstract: BACKGROUND
  The decline of infections in childhood may contribute to the rising severity and prevalence of atopic disorders in developed countries. With this regard, we examined the relationship of frequent tonsillitis and consequent tonsillar hyperplasia with the development of asthma.
  
  
  METHODS
  Sixty-seven asthmatic children (ages 3-14) who had no signs or symptoms of acute tonsillitis were included. The control group consisted of 92 randomly selected children who had no signs or symptoms of asthma or acute tonsillitis. Parents were interviewed about the incidence of tonsillitis diagnosed by physicians and history of tonsillectomy; tonsil sizes were evaluated by oropharyngeal inspection by the same observer using the Brodsky L. Scala.
  
  
  RESULTS
  A statistically significant association is found between frequent tonsillitis and consequent tonsillar hyperplasia with the development of asthma.
  
  
  CONCLUSIONS
  Our data suggests that recurrent tonsillitis is associated with a decline in the prevalence of asthma by inducing a Th 1 predominant immune response. Our findings are compatible with the hygiene hypothesis.
authors.affiliation: Department of Pediatrics, Haydarpasa Numune Training Hospital, Istanbul, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Ceran
authors.forename: Sibel
authors.initials: S
authors.lastname: Aka
authors.forename: Devrim
authors.initials: D
authors.lastname: Oztemel
authors.forename: Burcu
authors.initials: B
authors.lastname: Uyanik
authors.forename: Tamay
authors.initials: T
authors.lastname: Ozkozaci
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000209:etiology* / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology / Q000473:pathology*; D012008:Recurrence; D014069:Tonsillitis / Q000175:diagnosis / Q000276:immunology*