Analysis of lectin receptors in normal nasal mucosa, nasal polyp, inverted papilloma and papillary adenocarcinoma.
In order to investigate the changes in glycoprotein structure in the process of cellular differentiation of the nasal mucosa, formalin-fixed, paraffin-embedded biopsy specimens of normal nasal mucosae, nasal polyps, inverted papillomas and papillary adenocarcinomas were analysed by the Avidin Biotin-Peroxidase Complex technique for the demonstration of peanut agglutinin (PNA) receptors, concanavalin ensifomis agglutinin (ConA) receptors, ulex europeaus agglutinin (UEA-I) receptors, wheat germ agglutinin (WGA) receptors, carcino-embryonic antigen (CEA) and keratin. The quantity and distribution of PNA receptors, ConA receptors, UEA-I receptors and CEA were different, in relation to the varying pathological changes. The results suggest that the glycoprotein structure in the cells of the nasal mucosa will change following their differentiation and malignant transformation, which may be helpful in establishing the diagnosis.
Huang
H
H
Department of Otolaryngology, Changhai Hospital, Shanghai, China.
Jing
D
D
Li
Z
Z
Zhou
S
S
Xiao
S
S
Ma
D
D
Zhang
R
R
D000231:Adenocarcinoma, Papillary / Q000737:chemistry* / Q000175:diagnosis; D002454:Cell Differentiation; D006801:Humans; D009297:Nasal Mucosa / Q000737:chemistry*; D009298:Nasal Polyps / Q000737:chemistry* / Q000175:diagnosis; D009669:Nose Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D018308:Papilloma, Inverted / Q000737:chemistry* / Q000175:diagnosis; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000032:analysis; D011952:Receptors, Concanavalin A / Q000032:analysis; D011975:Receptors, Mitogen / Q000032:analysis* / Q000378:metabolism
D011956:Receptors, Cell Surface; D011952:Receptors, Concanavalin A; D011975:Receptors, Mitogen; C053203:Ulex europaeus lectin receptor; C038223:peanut agglutinin receptor; C027503:wheat germ agglutinin receptor