Synthesis of cyclic beta-amino acid esters from methionine, allylglycine, and serine.
Here we report a versatile ring-closing metathesis-based approach to 5-, 6-, and 7-membered cyclic beta-amino esters starting with simple and readily available building blocks-methionine, allylglycine, and serine-where the nature of the amino acid determines the size of the carbocyclic ring.
Gardiner
James
J
Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
Anderson
Kelly H
KH
Downard
Alison
A
Abell
Andrew D
AD
D000501:Allylglycine / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004952:Esters / Q000138:chemical synthesis*; D008715:Methionine / Q000737:chemistry*; D015394:Molecular Structure; D012694:Serine / Q000737:chemistry*
D000596:Amino Acids; D004952:Esters; D000501:Allylglycine; D012694:Serine; D008715:Methionine