title: Modeling operon dynamics: the tryptophan and lactose operons as paradigms.
abstract: Understanding the regulation of gene control networks and their ensuing dynamics will be a critical component in the understanding of the mountain of genomic data being currently collected. This paper reviews recent mathematical modeling work on the tryptophan and lactose operons which are, respectively, the classical paradigms for repressible and inducible operons.
authors.affiliation: Department of Physiology, Centre for Nonlinear Dynamics, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada H3G 1Y6. mackey@cnd.mcgill.ca
authors.forename: Michael C
authors.initials: MC
authors.lastname: Mackey
authors.forename: Moisés
authors.initials: M
authors.lastname: Santillán
authors.forename: Necmettin
authors.initials: N
authors.lastname: Yildirim
mesh_terms: D004926:Escherichia coli / Q000235:genetics; D005786:Gene Expression Regulation; D007785:Lactose / Q000235:genetics*; D008433:Mathematics; D008957:Models, Genetic; D009876:Operon / Q000235:genetics*; D014364:Tryptophan / Q000235:genetics*
chemical_list: D014364:Tryptophan; D007785:Lactose