DNA pooling as a tool for large-scale association studies in complex traits.
Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.
Norton
Nadine
N
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK. nortonn@cardiff.ac.uk
Williams
Nigel M
NM
O'Donovan
Michael C
MC
Owen
Michael J
MJ
D004247:DNA / Q000032:analysis*; D005787:Gene Frequency; D005788:Gene Pool; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D010641:Phenotype; D019655:Quantitative Trait, Heritable
D004247:DNA