A metastasis of an adenocarcinoma in a BRCA1 mutation carrier, a diagnostic problem not solved by morphology alone.
To increase awareness of the possible coexistence of an ovarian and breast carcinoma in a BRCA1 mutation carrier, we describe a patient with primary ovarian cancer who developed distant metastases after 3 years and again after 6 years. Surprisingly, at that time an occult breast carcinoma was identified to be the origin of the 2 metastatic locations as confirmed by molecular analysis. Eventually the patient could be treated accordingly.
Kuenen-Boumeester
Vibeke
V
Department of Pathology, Erasmus Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
Den Bakker
Michael
M
Dinjens
Winand N m
WN
Seynaeve
Caroline
C
D000230:Adenocarcinoma / Q000556:secondary*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D005260:Female; D019398:Genes, BRCA1; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009154:Mutation; D016609:Neoplasms, Second Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D016133:Polymerase Chain Reaction; D035441:Thoracic Wall / Q000473:pathology