Effects of recombinant human growth hormone on remnant liver after hepatectomy in hepatocellular carcinoma with cirrhosis.
OBJECTIVE
To explore the effects of recombinant human growth hormone (rhGH) on the remnant liver after hepatectomy in hepatocellular carcinoma with liver cirrhosis.


METHODS
Twenty-four patients with hepatocellular carcinoma who underwent hepatectomy were randomly divided into 2 groups: parenteral nutrition (PN) group (n=12) and rhGH+PN group (n=12). Liver function, blood glucose, AFP, serum prealbumin and transferrin were detected before operation, at post-operative d 1 and d 6. Albumin (ALB) mRNA in liver biopsy specimens was detected by RT-PCR at post-operative d 6. Liver Ki67 immunohistochemical staining was studied.


RESULTS
On post-operative d 6, compared with PN group, the levels of blood glucose, serum prealbumin, transferrin, the expression of hepatic ALB mRNA and liver Ki67 labeling index were higher in rhGH+PN group.


CONCLUSIONS
rhGH can improve protein synthesis and liver regeneration after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
Luo
Shi-Min
SM
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 56 Zhongshan Er Lu, Guangzhou 510080, Guangdong Province, China.
Liang
Li-Jian
LJ
Lai
Jia-Ming
JM
D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008113:Liver Neoplasms / Q000601:surgery*; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011994:Recombinant Proteins / Q000494:pharmacology*; D014168:Transferrin / Q000378:metabolism
D000418:Albumins; D001786:Blood Glucose; D019394:Ki-67 Antigen; D011994:Recombinant Proteins; D014168:Transferrin; D019382:Human Growth Hormone