title: Monitoring change in the three-dimensional shape of the human left ventricle.
abstract: BACKGROUND
  Characterizing left ventricular (LV) remodeling after myocardial infarction or LV shape change resulting from LV shape-restoration operation can yield valuable prognostic information. However, current methods measure only global parameters of LV shape.
  
  
  METHODS
  We developed and validated a method for measuring change in regional LV shape by aligning a patient's follow-up 3-dimensional LV surface reconstruction to baseline surface. We tested the diagnostic power of 6 distance functions to detect a known shape deformation. To create the test data, the LV endocardial surface of a control subject was reconstructed using 3-dimensional echocardiographic techniques. The surface was deformed 9 different ways to model LV dilation (3 different locations and severities). Normal shape variability was defined from 18 serial studies of 6 control subjects. The severity of regional dilation was computed as the orthogonal distance between the aligned baseline and deformed LV surfaces. Deformation was quantified according to regional location using the 16-segment map of the LV.
  
  
  RESULTS
  Normal LV shape variability was 3.38 mm. The LV deformations ranged from 2.95 to 8.02 mm. Gaussian distance function produced the highest accuracy for measuring deformation distances (P <.005 by analysis of variance). In addition, the gaussian function correctly identified the location of the maximum deformation in 6 of the 9 distorted surfaces. In the 3 remaining surfaces, the gaussian alignment selected an adjacent basal segment with a similar deformation distance (mean error: 0.2 +/- 0.17 mm). The gaussian function's accuracy in pinpointing the deformation equaled or exceeded the performance of the other 5 functions tested.
  
  
  CONCLUSIONS
  This new method of aligning 3-dimensional LV surfaces in space facilitates detecting, measuring, and localizing regional shape change in the human LV independent of anatomic landmarks or geometric references. Potential applications include quantitative monitoring of change in regional LV shape after a pathologic process and/or surgical procedure to document efficacy of treatment and to assess prognosis.
authors.affiliation: Cardiovascular Research and Training Center, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Michal
authors.initials: M
authors.lastname: Hubka
authors.forename: John A
authors.initials: JA
authors.lastname: McDonald
authors.forename: Selwyn
authors.initials: S
authors.lastname: Wong
authors.forename: Edward L
authors.initials: EL
authors.lastname: Bolson
authors.forename: Florence H
authors.initials: FH
authors.lastname: Sheehan
mesh_terms: D019560:Echocardiography, Three-Dimensional / Q000379:methods; D006352:Heart Ventricles / Q000033:anatomy & histology* / Q000000981:diagnostic imaging*; D006801:Humans; D016011:Normal Distribution; D016276:Ventricular Function; D020257:Ventricular Remodeling / Q000502:physiology