title: Nizatidine and cisapride increase salivary secretion in rats.
abstract: Saliva is a neurally induced solution with buffering capacity against acidic solutions. Salivation therefore plays an important role in defending the esophageal mucosa against refluxed gastric acid and is evoked by cholinergic stimulation. Both nizatidine and cisapride are reported to increase acetylcholine concentrations in the postganglionic cholinergic synapses. We performed this study to clarify the effect of administration of nizatidine and cisapride on salivary secretion. Eight-week-old male Sprague-Dawley rats were used for the experiments. Histamine-stimulated gastric acid secretion was measured after intraduodenal administration of nizatidine or famotidine to determine the equipotent acid-suppressing doses. Salivary secretion was then measured for 3 hr after intraduodenal administration of nizatidine (30 mg/kg), famotidine (3 mg/kg), or cisapride (1 mg/kg). Both nizatidine and famotidine dose-dependently inhibited histamine-stimulated gastric acid secretion. Total salivary secretion was significantly increased by nizatidine (P = 0.02) and cisapride (P = 0.02) but not by famotidine (P = 0.50) compared with controls.
authors.affiliation: Department of Gastroenterology and Hepatology, Shimane University, Shimane, Japan. kadachi@med.shimane-u.ac.jp
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Adachi
authors.forename: Kenji
authors.initials: K
authors.lastname: Furuta
authors.forename: Tomoko
authors.initials: T
authors.lastname: Katsube
authors.forename: Tomoo
authors.initials: T
authors.lastname: Fujisawa
authors.forename: Takane
authors.initials: T
authors.lastname: Azumi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Fujishiro
authors.forename: Shunji
authors.initials: S
authors.lastname: Ishihara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Amano
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000818:Animals; D020117:Cisapride / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D008297:Male; D016567:Nizatidine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012472:Salivation / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
chemical_list: D006635:Histamine H2 Antagonists; D017366:Serotonin Receptor Agonists; D016567:Nizatidine; D020117:Cisapride