Beta-lactotensin and neurotensin rapidly reduce serum cholesterol via NT2 receptor.
Beta-lactotensin, a neurotensin NT2 agonist derived from beta-lactoglobulin, has hypocholesterolemic activity after administration for 2 days at a dose of 30 mg/kg (i.p.) or 100 mg/kg (p.o.) for 2 days in mice fed a high-cholesterol/cholic acid diet. The onset of hypocholesterolemic activity of beta-lactotensin was observed 90 min after a single i.p. or p.o. administration at the same dose as described above. Neurotensin also induced hypocholesterolemic activity 90 min after single i.p. administration at a dose of 2 microg per mouse but was ineffective after oral administration. The rapid onset of hypocholesterolemic activities of beta-lactotensin and neurotensin was blocked by levocabastine (50 microg/kg), an NT2 antagonist, and raclopride (0.5 mg/kg), a dopamine D2 antagonist.
Yamauchi
Rena
R
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Ohinata
Kousaku
K
Yoshikawa
Masaaki
M
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D018492:Dopamine Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009496:Neurotensin / Q000819:agonists / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009842:Oligopeptides / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D010880:Piperidines / Q000494:pharmacology; D020891:Raclopride / Q000494:pharmacology; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors / Q000378:metabolism*
D018492:Dopamine Antagonists; C490984:Ntsr2 protein, mouse; D009842:Oligopeptides; D010880:Piperidines; D018028:Receptors, Neurotensin; C102984:beta-lactotensin; D009496:Neurotensin; D020891:Raclopride; D002784:Cholesterol; C047340:levocabastine