title: Meta-analysis of autologous bone marrow transplantation versus chemotherapy in adult patients with acute myeloid leukemia in first remission.
abstract: In the present study, we have conducted a meta-analysis comparing autologous bone marrow transplantation (ABMT) and intensive chemotherapy in adult acute myeloid leukemia (AML) patients in first remission. Combined results of the six appropriate randomised controlled studies indicate that ABMT had no advantage over chemotherapy or no further treatment concerning death rate (overall rate ratio (RR)-0.95, 95% CI, 0.81-1.11), while was superior to chemotherapy concerning event rate (overall RR--0.82, 95% CI, 0.71-0.94). In conclusion, ABMT did not improve survival but it improved event-free survival (EFS) when compared with chemotherapy or no further treatment in patients with AML in first complete remission.
authors.affiliation: Institute of Hematology, Soroka University Medical Center, PO Box 151, Be'er-Sheva 84101, Israel. etail@clalit.org.il
authors.forename: Itai
authors.initials: I
authors.lastname: Levi
authors.forename: Itamar
authors.initials: I
authors.lastname: Grotto
authors.forename: Ronit
authors.initials: R
authors.lastname: Yerushalmi
authors.forename: Isaac
authors.initials: I
authors.lastname: Ben-Bassat
authors.forename: Ofer
authors.initials: O
authors.lastname: Shpilberg
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000628:therapy*; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012074:Remission Induction; D014182:Transplantation, Autologous; D016896:Treatment Outcome