Resistance of HIV-infected cells to cytotoxic T lymphocytes.
Although cytotoxic T lymphocytes (CTLs) are important for controlling HIV, CTLs are not effective at eradicating HIV infection. Recent studies have revealed a combination of factors that together make HIV-infected cells resistant to CTLs and make anti-HIV CTLs ineffective. These factors likely contribute to prolonged survival of infected target cells, which in turn increases the probability of antigenic variation and immune escape.
Collins
Kathleen L
KL
Department of Internal Medicine, The University of Michigan, Ann Arbor 48109, USA. klcollin@umich.edu
D000940:Antigenic Variation; D017209:Apoptosis; D003602:Cytotoxicity, Immunologic; D015536:Down-Regulation; D006678:HIV / Q000276:immunology / Q000472:pathogenicity*; D015488:HIV Antigens / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D015488:HIV Antigens; D015395:Histocompatibility Antigens Class I