Mitosis: MCAK under the aura of Aurora B.
Two new studies show that phosphorylation by Aurora B kinase controls the centromere localization and catalytic activity of the microtubule depolymerase MCAK. Physical tension from microtubule attachment may influence access of MCAK to Aurora B kinase and its opposing phosphatases.
Gorbsky
Gary J
GJ
Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, Oklahoma 73104, USA.
D064107:Aurora Kinase B; D064127:Aurora Kinases; D002384:Catalysis; D002503:Centromere / Q000502:physiology*; D016547:Kinesins / Q000378:metabolism* / Q000502:physiology; D008870:Microtubules / Q000378:metabolism* / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism* / Q000502:physiology
C091489:KIF2C protein, human; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D016547:Kinesins