Suppression of dioxin mediated aryl hydrocarbon receptor transformation by ethanolic extracts of propolis.
Present study demonstrated that the ethanolic extracts of propolis containing higher concentrations of flavonoids suppressed 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor transformation in a dose-dependent manner. The IC(50) values of propolis group 3 and group 12 were 1.2 and 3.6 microg/ml, respectively, indicating that propolis showed stronger antagonistic effects as compared with vegetable extracts.
Park
Yong K
YK
State University of Campinas, College of Food Engineering (UNICAMP), Department of Food Science, Laboratory of Food Biochemistry, SP, Brazil. ykpark@fea.unicamp.br
Fukuda
Itsuko
I
Ashida
Hitoshi
H
Nishiumi
Shin
S
Guzman
Julio Paredes
JP
Sato
Helia H
HH
Pastore
Glaucia M
GM
D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D005786:Gene Expression Regulation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D000072317:Polychlorinated Dibenzodioxins / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D011429:Propolis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D018336:Receptors, Aryl Hydrocarbon / Q000378:metabolism*; D013489:Suppression, Genetic / Q000235:genetics; D014675:Vegetables / Q000737:chemistry
D005419:Flavonoids; D010936:Plant Extracts; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D000431:Ethanol; D011429:Propolis