Polychlorinated androstanes from the burrowing sponge Cliona nigricans.
Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetrachlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic.
Fattorusso
Ernesto
E
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli "Federico II", Via D. Montesano 49, I-80131 Napoli, Italy. fattoru@unina.it
Taglialatela-Scafati
Orazio
O
Petrucci
Francesca
F
Bavestrello
Giorgio
G
Calcinai
Barbara
B
Cerrano
Carlo
C
Di Meglio
Paola
P
Ianaro
Angela
A
D000731:Androstanes / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*
D000731:Androstanes; C494536:clionastatin A; C494535:clionastatin B