title: Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
abstract: Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs.
authors.affiliation: Pfizer Global Research and Development, CVMD Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA. richard_chesworth@groton.pfizer.com
authors.forename: Richard
authors.initials: R
authors.lastname: Chesworth
authors.forename: Michael P
authors.initials: MP
authors.lastname: Zawistoski
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Lefker
authors.forename: Kimberly O
authors.initials: KO
authors.lastname: Cameron
authors.forename: Robert F
authors.initials: RF
authors.lastname: Day
authors.forename: F Michael
authors.initials: FM
authors.lastname: Mangano
authors.forename: Robert L
authors.initials: RL
authors.lastname: Rosati
authors.forename: Stacy
authors.initials: S
authors.lastname: Colella
authors.forename: Donna N
authors.initials: DN
authors.lastname: Petersen
authors.forename: Amy
authors.initials: A
authors.lastname: Brault
authors.forename: Bihong
authors.initials: B
authors.lastname: Lu
authors.forename: Lydia C
authors.initials: LC
authors.lastname: Pan
authors.forename: Pia
authors.initials: P
authors.lastname: Perry
authors.forename: Oicheng
authors.initials: O
authors.lastname: Ng
authors.forename: Tessa A
authors.initials: TA
authors.lastname: Castleberry
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Owen
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Brown
authors.forename: David D
authors.initials: DD
authors.lastname: Thompson
authors.forename: Paul
authors.initials: P
authors.lastname: DaSilva-Jardine
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D047628:Estrogen Receptor alpha / Q000737:chemistry; D047629:Estrogen Receptor beta / Q000737:chemistry; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D011485:Protein Binding; D020845:Selective Estrogen Receptor Modulators / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D008024:Ligands; D020845:Selective Estrogen Receptor Modulators; D044005:Tetrahydroisoquinolines