Lipoxygenase inhibiting and antioxidant oligostilbene and monoterpene galactoside from Paeonia emodi.
Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition, 4-hydroxybenzoic acid 3, gallic acid 4 and methyl gallate 5 have also been reported for the first time from this species. Compounds 1 and 2 have displayed potent inhibitory potential against enzyme lipoxygenase in a concentration-dependent fashion with the IC(50) values 0.77 and 99.5 microM, along with ABTS(.+) radical quenching activity with IC(50) values of 147.5 and 498.2 microM, respectively.
Riaz
Naheed
N
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Malik
Abdul
A
Rehman
Aziz-ur
AU
Ahmed
Zaheer
Z
Muhammad
Pir
P
Nawaz
Sarfraz Ahmad
SA
Siddiqui
Juveria
J
Choudhary
Muhammad Iqbal
MI
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D005697:Galactosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D029596:Paeonia / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D005697:Galactosides; D016859:Lipoxygenase Inhibitors; D039821:Monoterpenes; D010936:Plant Extracts; D013267:Stilbenes; C006680:baicalein