A multi-site comparison of psychosocial approaches for the treatment of methamphetamine dependence.
OBJECTIVE
The Center for Substance Abuse Treatment (CSAT) Methamphetamine Treatment Project (MTP) is the largest randomized clinical trial of treatments for methamphetamine (MA) dependence to date. The objective of the study was to compare the Matrix Model, a manualized treatment method, with treatment-as-usual (TAU) in eight community out-patient settings in the Western United States.


METHODS
Over an 18-month period between 1999 and 2001, 978 treatment-seeking, MA-dependent people were randomly assigned to receive either TAU at each site or a manualized 16-week treatment (Matrix Model).


METHODS
The study was conducted as an eight-site out-patient trial, with six sites located in California and one each in Montana and Hawaii.


RESULTS
In the overall sample, and in the majority of sites, those who were assigned to Matrix treatment attended more clinical sessions, stayed in treatment longer, provided more MA-free urine samples during the treatment period and had longer periods of MA abstinence than those assigned to receive TAU. Measures of drug use and functioning collected at treatment discharge and 6 months post-admission indicate significant improvement by participants in all sites and conditions when compared to baseline levels, but the superiority of the Matrix approach did not persist at these two timepoints.


CONCLUSIONS
Study results demonstrate a significant initial step in documenting the efficacy of the Matrix approach. Although the superiority of the Matrix approach over TAU was not maintained at the post-treatment timepoints, the in-treatment benefit is an important demonstration of empirical support for this psychosocial treatment approach.
Rawson
Richard A
RA
University of California, Los Angeles, Integrated Substance Abuse Programs, USA. matrixex@ucla.edu
Marinelli-Casey
Patricia
P
Anglin
M Douglas
MD
Dickow
Alice
A
Frazier
Yvonne
Y
Gallagher
Cheryl
C
Galloway
Gantt P
GP
Herrell
James
J
Huber
Alice
A
McCann
Michael J
MJ
Obert
Jeanne
J
Pennell
Susan
S
Reiber
Chris
C
Vandersloot
Denna
D
Zweben
Joan
J
D000293:Adolescent; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000523:psychology / Q000628:therapy*; D000697:Central Nervous System Stimulants; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008694:Methamphetamine; D016896:Treatment Outcome; D014481:United States; D014482:United States Substance Abuse and Mental Health Services Administration
D000697:Central Nervous System Stimulants; D008694:Methamphetamine