title: Interaction between HIV-1 and HCV infections: towards a new entity?
abstract: Since human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share the same modes of transmission, HIV-HCV co-infected patients are relatively common. Until recently, the clinical course of HCV in co-infected patients was overshadowed by the high morbidity and mortality of HIV disease. Recent reductions in morbidity and mortality among HIV-infected patients due to the advent of highly active antiretroviral therapy (HAART), have contributed to the emergence of HCV as a significant viral pathogen in this population. This article reviews the current evidence on the epidemiology and clinical implications of an interaction between HIV-1 and HCV infections.
authors.affiliation: INSERM U593, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux, France. Maria.Winnock@isped.u-bordeaux2.fr
authors.forename: Maria
authors.initials: M
authors.lastname: Winnock
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon-Céron
authors.forename: François
authors.initials: F
authors.lastname: Dabis
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chêne
mesh_terms: D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D015497:HIV-1; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D006801:Humans
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents