title: Urinary leukotriene E4 correlates with severity of atopic dermatitis in children.
abstract: Leukotriene E4 (LTE(4)) is elevated in adults with atopic dermatitis (AD). We evaluated whether urinary LTE(4) as a noninvasive marker correlates with clinical indices of disease activity in children with AD. AD patients aged 18 years or younger were eligible for inclusion in the study. Disease severity over the preceding 3 days was evaluated by the SCORing Atopic Dermatitis (SCORAD) index. Severity of AD over the past 12 months was evaluated by the Nottingham Eczema Severity Score (NESS) in Chinese. Urinary LTE(4) concentration was measured by competitive enzyme immunoassay. One hundred and twenty-six children with AD (82 boys and 44 girls) and 45 controls were recruited. The mean +/- SD urinary log-transformed LTE(4) concentration in AD patients and controls was 2.94 +/- 0.32 and 2.62 +/- 0.20 pg/mg creatinine, respectively (P < 0.0001). SCORAD significantly correlated with NESS (r = 0.681, P < 0.0001). There were significant correlations between urinary LTE(4) concentration and overall SCORAD score (r = 0.270, P = 0.002) and its extent (r = 0.185, P = 0.038) and intensity components (r = 0.247, P = 0.005), but not with NESS. When compared with mild AD, urinary LTE(4) concentrations were higher in patients with moderate-to-severe disease (P = 0.049). Urinary LTE(4) measurement is noninvasive and may be useful in supplementing the SCORAD for following longitudinal changes in AD severity in children. However, the practical value of this assay in a clinical setting remains to be determined.
authors.affiliation: Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China. ehon@hotmail.com
authors.forename: K L E
authors.initials: KL
authors.lastname: Hon
authors.forename: T F
authors.initials: TF
authors.lastname: Leung
authors.forename: K C
authors.initials: KC
authors.lastname: Ma
authors.forename: A M
authors.initials: AM
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Wong
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: I H S
authors.initials: IH
authors.lastname: Chan
authors.forename: T F
authors.initials: TF
authors.lastname: Fok
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000652:urine; D002648:Child; D003404:Creatinine / Q000652:urine; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000652:urine*; D005260:Female; D006801:Humans; D017999:Leukotriene E4 / Q000652:urine*; D008297:Male; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D017999:Leukotriene E4; D003404:Creatinine