title: Cloning of TLR3 isoform.
abstract: Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2,520 bp cDNAs compared to the 2,712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is co-expressed with wild type TLR3 in primary human astrocytes and glioblastoma cell lines. This finding suggests the TLR3 isoform in astrocytes may have a different immunological role for binding ligands during the immune response in brain.
authors.affiliation: Department of Microbiology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Eunjeong
authors.initials: E
authors.lastname: Yang
authors.forename: Jeon-Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Hyemi
authors.initials: H
authors.lastname: Kim
authors.forename: Hyoung Woo
authors.initials: HW
authors.lastname: Park
authors.forename: Myoung Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Se Jong
authors.initials: SJ
authors.lastname: Kim
authors.forename: In-Hong
authors.initials: IH
authors.lastname: Choi
mesh_terms: D001253:Astrocytes / Q000502:physiology*; D003001:Cloning, Molecular; D006801:Humans; D007536:Isomerism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics*; D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors
chemical_list: D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors