Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction.
This study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. Deoxypodophyllotoxin was tested in a rat PCA (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). Deoxypodophyllotoxin dose-dependently inhibited the PCA reaction activated by anti-dinitrophenyl (DNP) IgE. The PCA inhibitory activity of deoxypodophyllotoxin was stronger than those of prednisolone and indomethacin, which were used as positive controls. These results suggest that deoxypodophyllotoxin may be beneficial in regulating the immediate-type allergic reaction.
Lin
Chang Xiu
CX
College of Pharmacy, Yeungnam University, Gyongsan, Korea.
Son
Min Jung
MJ
Ju
Hye Kyung
HK
Moon
Tae Chul
TC
Lee
Eunkyung
E
Kim
So Hee
SH
Kim
Mi-Jeong
MJ
Son
Jong Keun
JK
Lee
Seung Ho
SH
Chang
Hyeun Wook
HW
D000818:Animals; D019661:Apiaceae; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D017705:Lignans; D010936:Plant Extracts; C014451:deoxypodophyllotoxin; D011034:Podophyllotoxin