title: Effects of recombinant human growth hormone on remnant liver after hepatectomy in hepatocellular carcinoma with cirrhosis.
abstract: OBJECTIVE
  To explore the effects of recombinant human growth hormone (rhGH) on the remnant liver after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
  
  
  METHODS
  Twenty-four patients with hepatocellular carcinoma who underwent hepatectomy were randomly divided into 2 groups: parenteral nutrition (PN) group (n=12) and rhGH+PN group (n=12). Liver function, blood glucose, AFP, serum prealbumin and transferrin were detected before operation, at post-operative d 1 and d 6. Albumin (ALB) mRNA in liver biopsy specimens was detected by RT-PCR at post-operative d 6. Liver Ki67 immunohistochemical staining was studied.
  
  
  RESULTS
  On post-operative d 6, compared with PN group, the levels of blood glucose, serum prealbumin, transferrin, the expression of hepatic ALB mRNA and liver Ki67 labeling index were higher in rhGH+PN group.
  
  
  CONCLUSIONS
  rhGH can improve protein synthesis and liver regeneration after hepatectomy in hepatocellular carcinoma with liver cirrhosis.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, 56 Zhongshan Er Lu, Guangzhou 510080, Guangdong Province, China.
authors.forename: Shi-Min
authors.initials: SM
authors.lastname: Luo
authors.forename: Li-Jian
authors.initials: LJ
authors.lastname: Liang
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Lai
mesh_terms: D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008113:Liver Neoplasms / Q000601:surgery*; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D011994:Recombinant Proteins / Q000494:pharmacology*; D014168:Transferrin / Q000378:metabolism
chemical_list: D000418:Albumins; D001786:Blood Glucose; D019394:Ki-67 Antigen; D011994:Recombinant Proteins; D014168:Transferrin; D019382:Human Growth Hormone