Characterization of curcumin-PVP solid dispersion obtained by spray drying.
Curcumin, a naturally occurring highly lipophilic molecule has wide range of pharmacological activities. However, its limited aqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersions of curcumin in different ratios with PVP were prepared by spray drying. Physical characterization by SEM, IR, DSC, and XRPD studies, in comparison with corresponding physical mixtures revealed the changes in solid state during the formation of dispersion and justified the formation of high-energy amorphous phase. Dissolution studies of curcumin and its physical mixtures in 0.1 N HCl showed negligible release even after 90 min. Whereas, solid dispersions showed complete dissolution within 30 min. This may aid in improving bioavailability and dose reduction of the drug.
Paradkar
Anant
A
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandawane, Pune 411 038, Maharashtra, India. arparadkar@rediffmail.com
Ambike
Anshuman A
AA
Jadhav
Bhimrao K
BK
Mahadik
K R
KR
D002152:Calorimetry, Differential Scanning; D003474:Curcumin / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods
D011205:Povidone; D003474:Curcumin