title: Influenza-associated encephalitis/encephalopathy with a reversible lesion in the splenium of the corpus callosum: a case report and literature review.
abstract: We report the cases of two patients with influenza-associated encephalitis/encephalopathy (IAEE) who presented with mild CNS manifestations and complete recovery within a few days. Initial MR imaging at days 4 and 5 revealed a lesion in the central portion of the splenium of the corpus callosum with a reduced apparent diffusion coefficient (ADC) value, which completely resolved on follow-up studies at day 10. We postulate two possible mechanisms for decreased ADC; namely, intramyelinic edema and an inflammatory infiltrate.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Takanashi
authors.forename: A James
authors.initials: AJ
authors.lastname: Barkovich
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kohno
mesh_terms: D002648:Child; D003337:Corpus Callosum; D038524:Diffusion Magnetic Resonance Imaging; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000821:virology*; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000175:diagnosis*; D008297:Male