Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination.
Passive antibody treatment of macaques prior to simian/human immunodeficiency virus infection produces "sterilizing immunity" in some animals and long-term reductions in viral loads in others. Analysis of viral kinetics suggests that antibody mediates sterilizing immunity by its effects on the initial viral inoculum. By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control.
Zhang
Lei
L
Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia.
Ribeiro
Ruy M
RM
Mascola
John R
JR
Lewis
Mark G
MG
Stiegler
Gabriela
G
Katinger
Hermann
H
Perelson
Alan S
AS
Davenport
Miles P
MP
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D007116:Immunization, Passive; D008251:Macaca; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D019562:Viral Load
D000914:Antibodies, Viral