title: Impaired vascular reactivity of isolated rat middle cerebral artery after cortical spreading depression in vivo.
abstract: Cortical spreading depression (CSD) is accompanied by hyperemia followed by long-lasting hypoperfusion and impaired cerebrovascular reactivity. The authors show that vasodilation to extraluminal acidosis (pH 7.0) and increased concentrations of extraluminal potassium (12, 20, 40 mmol/L) was significantly reduced in isolated rat middle cerebral arteries after CSD in vivo before the artery was isolated, compared with sham-operated controls. Application of 80-mmol/L potassium induced vasoconstriction after CSD. Therefore, the impairment of vascular reactivity after CSD in vivo occurs, at least in part, at the vascular level itself.
authors.affiliation: Experimental Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
authors.forename: Iris
authors.initials: I
authors.lastname: Seitz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Dirnagl
authors.forename: Ute
authors.initials: U
authors.lastname: Lindauer
mesh_terms: D000818:Animals; D013181:Cortical Spreading Depression / Q000502:physiology*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D020768:Middle Cerebral Artery / Q000033:anatomy & histology / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D011188:Potassium