title: Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital.
abstract: Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical importance. In 2001, multidrug-resistant Pseudomonas aeruginosa carrying bla(VIM) MBL genes were found to be widespread (approximately 20% of all P. aeruginosa isolates and 70% of the carbapenem-resistant isolates) at Trieste University Hospital. Clonal diversity and heterogeneity of resistance determinants (either bla(VIM-1)-like or bla(VIM-2)-like) were detected among MBL producers. This evidence is the first that acquired MBLs can rapidly emerge and establish a condition of endemicity in certain epidemiologic settings.
authors.affiliation: Università di Trieste, Trieste, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Lagatolla
authors.forename: Enrico A
authors.initials: EA
authors.lastname: Tonin
authors.forename: Carlo
authors.initials: C
authors.lastname: Monti-Bragadin
authors.forename: Lucilla
authors.initials: L
authors.lastname: Dolzani
authors.forename: Francesca
authors.initials: F
authors.lastname: Gombac
authors.forename: Claudia
authors.initials: C
authors.lastname: Bearzi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Edalucci
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Gionechetti
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
mesh_terms: D015780:Carbapenems / Q000494:pharmacology*; D004351:Drug Resistance / Q000235:genetics*; D005060:Europe; D005838:Genotype; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D019105:Random Amplified Polymorphic DNA Technique; D018440:beta-Lactam Resistance / Q000187:drug effects / Q000235:genetics*
chemical_list: D015780:Carbapenems