Natural product glycorandomization.
glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.
Yang
Jie
J
Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, WI 53705, USA.
Hoffmeister
Dirk
D
Liu
Lesley
L
Fu
Xun
X
Thorson
Jon S
JS
D002240:Carbohydrate Sequence; D002384:Catalysis; D005686:Galactokinase / Q000737:chemistry* / Q000378:metabolism; D005964:Glucosyltransferases / Q000737:chemistry* / Q000378:metabolism; D006031:Glycosylation; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009713:Nucleotidyltransferases / Q000737:chemistry* / Q000378:metabolism; D013678:Technology, Pharmaceutical
D005964:Glucosyltransferases; C430144:glucosyltransferase E; D005686:Galactokinase; D009713:Nucleotidyltransferases; C020587:glucose-1-phosphate thymidylyltransferase