Grand mal seizure in a child 30 minutes after Cyclogyl (cyclopentolate hydrochloride) and 10% Neo-Synephrine (phenylephrine hydrochloride) eye drops were instilled.
A grand mal seizure is an unexpected, rare adverse event in a child receiving eye drops to dilate the pupils for an eye examination. A case is reported of a convulsion in a 23-month-old boy after he received Cyclogyl (cyclopentolate) and Neo-Synephrine (phenylephrine) eye drops before ophthalmoscopy. His serum sodium was 125 mEq/L, and he had low plasma pseudocholinesterase activity. Children exposed to organophosphate insecticides and other pseudocholinesterase inhibitors may be at risk for cyclopentolate toxicity.
Demayo
Alan P
AP
Department of Pediatrics, Weill Medical College of Cornell University, New York, New York 10021, USA.
Reidenberg
Marcus M
MM
D002091:Butyrylcholinesterase; D003519:Cyclopentolate / Q000009:adverse effects*; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D007306:Insecticides; D008297:Male; D009184:Mydriatics / Q000009:adverse effects*; D009883:Ophthalmic Solutions / Q000009:adverse effects; D009943:Organophosphorus Compounds; D010656:Phenylephrine / Q000009:adverse effects*
D007306:Insecticides; D009184:Mydriatics; D009883:Ophthalmic Solutions; D009943:Organophosphorus Compounds; D010656:Phenylephrine; D002091:Butyrylcholinesterase; D003519:Cyclopentolate