title: Elastic instability in growing yeast colonies.
abstract: The differential adhesion between cells is believed to be the major driving force behind the formation of tissues. The idea is that an aggregate of cells minimizes the overall adhesive energy between cell surfaces. We demonstrate in a model experimental system that there exist conditions where a slowly growing tissue does not minimize this adhesive energy. A mathematical model demonstrates that the instability of a spherical shape is caused by the competition between elastic and surface energies.
authors.affiliation: Department of Mathematics and Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: Baochi
authors.initials: B
authors.lastname: Nguyen
authors.forename: Arpita
authors.initials: A
authors.lastname: Upadhyaya
authors.forename: Alexander
authors.initials: A
authors.lastname: van Oudenaarden
authors.forename: Michael P
authors.initials: MP
authors.lastname: Brenner
mesh_terms: D000268:Adhesiveness; D000362:Agar / Q000737:chemistry; D001703:Biophysics / Q000379:methods*; D002448:Cell Adhesion; D004548:Elasticity; D007091:Image Processing, Computer-Assisted; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D013816:Thermodynamics
chemical_list: D000362:Agar