title: Heart rate variability in premenstrual dysphoric disorder.
abstract: Measuring heart rate variability (HRV) is a way to assess the autonomic regulation of the heart. Decreased HRV, indicating reduced parasympathetic tone, has previously been found in depression and anxiety disorders. The objective of this study was to assess HRV in women with premenstrual dysphoric disorder (PMDD). To this end, time domain variables and frequency domain variables were assessed in 28 women with PMDD and in 11 symptom-free controls during both the symptomatic luteal phase and the non-symptomatic follicular phase of the menstrual cycle. Two variables reflecting vagal activity in the time domain, the root mean square of differences of successive normal RR intervals (rMSSD) and standard deviation of normal RR intervals (SDNN) were lower in PMDD patients, but this difference was statistically significant in the follicular phase only. The most important vagal measure in the frequency domain, supine high frequency (HF), also appeared lower in PMDD subjects during the follicular phase. It is suggested that PMDD may be associated with reduced vagal tone compared to controls and that this difference is most apparent in the non-symptomatic follicular phase of the menstrual cycle.
authors.affiliation: Section of Psychiatry, Institute of Clinical Neuroscience, Göteborg University, Gothenburg, Sweden. landenm@msx.upmc.edu
authors.forename: Mikael
authors.initials: M
authors.lastname: Landén
authors.forename: Bertil
authors.initials: B
authors.lastname: Wennerblom
authors.forename: Hans
authors.initials: H
authors.lastname: Tygesen
authors.forename: Kjell
authors.initials: K
authors.lastname: Modigh
authors.forename: Karin
authors.initials: K
authors.lastname: Sörvik
authors.forename: Christina
authors.initials: C
authors.lastname: Ysander
authors.forename: Agneta
authors.initials: A
authors.lastname: Ekman
authors.forename: Hans
authors.initials: H
authors.lastname: Nissbrandt
authors.forename: Marie
authors.initials: M
authors.lastname: Olsson
authors.forename: Elias
authors.initials: E
authors.lastname: Eriksson
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology / Q000503:physiopathology*; D004311:Double-Blind Method; D015716:Electrocardiography, Ambulatory; D005260:Female; D005498:Follicular Phase / Q000502:physiology* / Q000523:psychology; D006321:Heart / Q000294:innervation; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008183:Luteal Phase / Q000502:physiology* / Q000523:psychology; D016555:Matched-Pair Analysis; D017374:Paroxetine / Q000494:pharmacology; D011293:Premenstrual Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology
chemical_list: D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors