Epilepsy and depression: imaging potential common factors.
Patients with seizure disorders have an increased incidence of depression. This may be due in part to psychosocial factors; or side effects of antiepileptic drugs. However, there may be underlying physiologic mechanisms for the relationship. Neuroimaging studies, including structural magnetic resonance imaging, positron emission tomography measurements of cerebral glucose metabolism, and, more recently, imaging of serotonin 1A receptors, may provide additional data to explain overlapping clinical manifestations of epilepsy and depression.
Theodore
William H
WH
Clinical Epilepsy Section, NINDS NIH, Building 10 Room 5N-250, Bethesda, MD 20892, USA. theodorw@ninds.nih.gov
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D003952:Diagnostic Imaging; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008280:Magnetics / Q000627:therapeutic use; D051379:Mice; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects / Q000502:physiology; D014630:Vagus Nerve / Q000503:physiopathology
D001786:Blood Glucose; D044282:Receptor, Serotonin, 5-HT1A