title: Epigenetic regulation of tumor suppressors in t(8:21)-containing AML.
abstract: The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Khalaf
authors.forename: L
authors.initials: L
authors.lastname: van de Locht
authors.forename: J H
authors.initials: JH
authors.lastname: Jansen
authors.forename: B A
authors.initials: BA
authors.lastname: van der Reijden
authors.forename: C
authors.initials: C
authors.lastname: Müller-Tidow
authors.forename: H Ruud
authors.initials: HR
authors.lastname: Delwel
authors.forename: H
authors.initials: H
authors.lastname: Serve
authors.forename: D W
authors.initials: DW
authors.lastname: Clapp
authors.forename: S W
authors.initials: SW
authors.lastname: Hiebert
mesh_terms: D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*