Down-regulation of model yeast proteins by ubiquitin-dependent proteolysis.
Ubiquitination is a versatile tool used by all eukaryotic organisms for controlling the stability, function, and intracellular localization of a multitude of proteins. I will attempt to bring together our recent data on the down-regulation of two yeast model proteins, the galactose transporter Gal2 and fructose-1,6-bisphosphatase, by ubiquitin-dependent proteolysis triggered by the addition of easily fermentable carbon sources.
Horák
J
J
Department of Membrane Transport, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic. horak@biomed.cas.cz
D015536:Down-Regulation; D006597:Fructose-Bisphosphatase / Q000235:genetics / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction; D025801:Ubiquitin / Q000378:metabolism*
C106901:GAL2 protein, S cerevisiae; D009004:Monosaccharide Transport Proteins; D029701:Saccharomyces cerevisiae Proteins; D025801:Ubiquitin; D006597:Fructose-Bisphosphatase; D005947:Glucose