title: The use of a continuous glucose monitoring system in hypoglycemic disorders.
abstract: OBJECTIVE
  To evaluate the use of a continuous glucose monitoring system (CGMS) in the evaluation and treatment of infants and children with hypoglycemic disorders.
  
  
  METHODS
  Patients with hypoglycemic disorders wore the CGMS device in the Pediatric Clinic Research Center during their evaluation and treatment. Capillary blood glucose (CBG) values were obtained at least 3 times each day and entered into the device for calibration purposes. We evaluated the number of hypoglycemic episodes below 3.3 mmol/l (60 mg/dl) detected by CGMS compared to CBG values and characterized episodes by their duration and intensity.
  
  
  RESULTS
  Five patients with hypoglycemic disorders were included in the study. There were a total of 13,369 sensor points, 343 paired sensor and CBG data points, and 57 days included. A total of 180 episodes of hypoglycemia occurred in these five patients, with an average duration of 55 +/- 13 minutes. Using a cut-off of 3.3 mmol/l (60 mg/dl) for hypoglycemia, the sensor had a sensitivity of 65.4%, specificity of 90.6%, and false positive rate of 42.9%. The positive and negative predictive values were 57.1% and 93.2%, respectively.
  
  
  CONCLUSIONS
  CGMS is a useful adjunct in the diagnosis and evaluation of hypoglycemia, and for documentation of euglycemia in these patients following therapy.
authors.affiliation: Department of Pediatrics, University of California at San Francisco, San Francisco 94143, USA.
authors.forename: Susan C
authors.initials: SC
authors.lastname: Conrad
authors.forename: John J
authors.initials: JJ
authors.lastname: Mastrototaro
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Gitelman
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation*; D002648:Child; D002675:Child, Preschool; D003625:Data Collection / Q000379:methods*; D005260:Female; D005544:Forecasting; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis*; D007223:Infant; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D001786:Blood Glucose