title: Accuracy of fine-needle aspiration cytology of salivary gland lesions in the netherlands cancer institute.
abstract: BACKGROUND
  To evaluate the accuracy of fine-needle aspiration cytology (FNAC) in salivary gland lesions in a tertiary referral center.
  
  
  METHODS
  A cytohistologic correlation study was performed using an automated pathology database of 1023 patients diagnosed with a salivary gland lesion.
  
  
  RESULTS
  In 388 cases, both cytology and histology were available. Using cytologic confirmation of malignancy as the starting point, the sensitivity, specificity, and accuracy of FNAC in this study were 88%, 99%, and 96%, respectively. Exact type-specific concordance of the malignant diagnosis was achieved in 66 (88%) of 75 cases and in 211 (95%) of 223 benign cases. Of the 19 cases with a cytologic diagnosis "cyst," four proved to be malignant. A non-neoplastic lesion at cytology proved to be correctly classified in 53 (68%) of 80 patients.
  
  
  CONCLUSIONS
  Our data show that cytology is a reliable and accurate technique to assess lesions of the salivary glands. The cytologic diagnosis of "cysts" and "non-neoplastic lesions" should be interpreted with caution.
authors.affiliation: Department of Head & Neck Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
authors.forename: Rolf J
authors.initials: RJ
authors.lastname: Postema
authors.forename: Mari-Louise F
authors.initials: ML
authors.lastname: van Velthuysen
authors.forename: Michiel W M
authors.initials: MW
authors.lastname: van den Brekel
authors.forename: Alfons J M
authors.initials: AJ
authors.lastname: Balm
authors.forename: Johannes L
authors.initials: JL
authors.lastname: Peterse
mesh_terms: D001707:Biopsy, Needle; D002173:Cancer Care Facilities; D016022:Case-Control Studies; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D009426:Netherlands; D012042:Registries; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D012469:Salivary Glands / Q000473:pathology*; D012680:Sensitivity and Specificity