title: The natural treatment of hypertension.
abstract: The goal of this review is to evaluate the efficacy of commonly available dietary supplements in the treatment of hypertension, using the average blood pressure reduction achieved with the implementation of lifestyle modifications as a standard. For this reason, the authors focus on the antihypertensive potential of these agents rather than pharmacology, pharmacokinetics, adverse effects, or supplement-drug interactions. For the purpose of this review, dietary supplements are defined as exhibiting some evidence of benefit if a systolic blood pressure reduction of 9.0 mm Hg or greater and/or a diastolic blood pressure reduction of 5.0 mm Hg or greater has been observed in previously published, peer-reviewed trials. These defining limits are based on the average blood pressure reduction associated with the implementation of certain lifestyle modifications. Agents with some evidence of benefit include coenzyme Q10, fish oil, garlic, vitamin C, and L-arginine.
authors.affiliation: University of Mississippi School of Pharmacy, University, MS, USA.
authors.forename: Amanda James
authors.initials: AJ
authors.lastname: Wilburn
authors.forename: Deborah S
authors.initials: DS
authors.lastname: King
authors.forename: James
authors.initials: J
authors.lastname: Glisson
authors.forename: Robin W
authors.initials: RW
authors.lastname: Rockhold
authors.forename: Marion R
authors.initials: MR
authors.lastname: Wofford
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001120:Arginine / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D003067:Coenzymes; D000529:Complementary Therapies; D019587:Dietary Supplements; D005395:Fish Oils / Q000627:therapeutic use; D005737:Garlic; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000628:therapy*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D003067:Coenzymes; D005395:Fish Oils; D014451:Ubiquinone; D001120:Arginine; C024989:coenzyme Q10; D001205:Ascorbic Acid