title: A visualisation concept of dynamic signalling networks.
abstract: Cellular processes and pathways are typically delineated in arrow diagrams to depict the relationship between the individual genes or proteins. These simplifications neglect the complexity and non-linearity of cellular regulatory networks. In this review, a three-dimensional (3D) visualisation model is presented that can be helpful in understanding the non-linear behaviour and limited predictability of regulatory networks, as well as their organisation, stability, attractor states, and evolution. A better understanding of the current views of large, complex scale-free networks can assist in planning and interpretation of high throughput microarray experiments.
authors.affiliation: Department of Urology, Josephine Nefkens Institute, Be362a, Erasmus MC, 3000 DR Rotterdam, The Netherlands. g,jenster@erasmusmc.nl
authors.forename: Guido
authors.initials: G
authors.lastname: Jenster
mesh_terms: D005075:Biological Evolution; D002468:Cell Physiological Phenomena; D003626:Data Display; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction