Tailoring of bioresorbable polymers for elaboration of sugar-functionalized nanoparticles.
Maleic copolymers with different contents of galactose moieties and dodecyl chains were synthesized and used as both a stabilizer and a surface coating for the preparation of poly(epsilon-caprolactone) nanoparticles by the emulsification-diffusion technique. The size of the nanoparticles was controlled by varying the initial concentration of the modified maleic copolymers. As the concentration of the latter increased, the particle size decreased, indicating that the copolymers serve as a stabilizer. Moreover, surface modification of nanoparticles was confirmed by xi-potential measurements. Nanoparticles were also shown to be recognized by a galactose-specific lectin, demonstrating the presence of galactose units on the particle surface. This approach offers opportunities for the production of novel targeted drug delivery systems.
Cade
David
D
Centre de Recherches sur les Macromolécules Végétales, BP53, 38041 Grenoble Cedex 9, France.
Ramus
Elsa
E
Rinaudo
Marguerite
M
Auzély-Velty
Rachel
R
Delair
Thierry
T
Hamaide
Thierry
T
D001672:Biocompatible Materials / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D036103:Nanotechnology; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
D001672:Biocompatible Materials; D002241:Carbohydrates; D011091:Polyesters; C016240:polycaprolactone