Lack of in vitro effect of ivermectin on Plasmodium falciparum.
The in vitro activity of ivermectin was assessed against the K1 isolate of Plasmodium falciparum. The mean IC50 and IC90 of ivermectin were 8.0 and 35.0 microg/ml, respectively. These results indicate that ivermectin has a very low activity against P. falciparum in vitro.
Nasveld
Peter
P
Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, QLD, Australia.
Russell
Bruce
B
Kotecka
Barbara
B
Rieckmann
Karl
K
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007559:Ivermectin / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D012044:Regression Analysis
D000981:Antiprotozoal Agents; D007559:Ivermectin