title: Antinociceptive profile of the methanolic extract of Neorautanenia mitis root in rats and mice.
abstract: The antinociceptive activity of the methanolic extract of Neorautenania mitis was studied in mice and rats. Five experimental models of nociception employed were: acetic acid-induced abdominal constriction and hot-plate test in mice, formalin-induced pain, analgesy-meter and Randall-Selitto tests in rats. The antinociceptive action of the extract was tested against naloxone in the hot-plate test in a bid to further elucidate probable mechanisms of antinociception. Results showed that the extract at doses of 5, 10 and 20 mg/kg body weight caused significant (P<0.05) dose-dependent antinociceptive activity in all the nociceptive models. Naloxone (2 mg/kg), significantly (P<0.05) antagonised the antinociceptive activity at the highest dose of the extract (20 mg). The study showed that the methanolic extract of Neorautanenia mitis possesses both peripherally and centrally mediated antinociceptive activity. The peripherally mediated action may be linked partly to lipoxygenases and/or cyclo-oxygenases, while the central anti-nociception is likely to be mediated via opioid receptors in the CNS.
authors.affiliation: Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P.M.B. 21, Abuja, Nigeria. vongtau@yahoo.com
authors.forename: H O
authors.initials: HO
authors.lastname: Vongtau
authors.forename: J
authors.initials: J
authors.lastname: Abbah
authors.forename: O
authors.initials: O
authors.lastname: Mosugu
authors.forename: B A
authors.initials: BA
authors.lastname: Chindo
authors.forename: I E
authors.initials: IE
authors.lastname: Ngazal
authors.forename: A O
authors.initials: AO
authors.lastname: Salawu
authors.forename: H O
authors.initials: HO
authors.lastname: Kwanashie
authors.forename: K S
authors.initials: KS
authors.lastname: Gamaniel
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D008297:Male; D016488:Medicine, African Traditional; D000432:Methanol / Q000737:chemistry; D051379:Mice; D009549:Nigeria; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D012997:Solvents; D000432:Methanol