title: The effect of C2-fluoro group on the biological activity of DC-81 and its dimers.
abstract: C2-Fluoro substituted pyrrolobenzodiazepines (PBDs) have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These C2-fluoro substituted PBDs also exhibit significant DNA-binding ability.
authors.affiliation: Biotransformation Laboratory, Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.ap.nic.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: P S M M
authors.initials: PS
authors.lastname: Reddy
authors.forename: D Rajasekhar
authors.initials: DR
authors.lastname: Reddy
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004247:DNA / Q000737:chemistry; D019281:Dimerization; D006801:Humans; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013696:Temperature
chemical_list: C474072:(11aS)-8-hydroxy-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5-one; D000970:Antineoplastic Agents; D009943:Organophosphorus Compounds; D001569:Benzodiazepines; D004247:DNA