title: [Expression of CGRP, ACTH and 5-HT in normal human lymph nodes].
abstract: OBJECTIVE
  To detect the expression of calcitonin-gene-related peptide (CGRP), adrenocorticotropin (ACTH), and serotonin (5-HT) in normal human lymph nodes and explore their influences on immune system.
  
  
  METHODS
  The expression of CGRP, ACTH and 5-HT in the lymph nodes, including proliferative lymph nodes, were detected by SABC Immunohistochemical staining.
  
  
  RESULTS
  In 35 cases of lymph node specimens, the positive rates of CGRP, ACTH and 5-HT expression were 88.5%(31/35), 85.4%(30/35) and 94.2%(33/35) respectively. These 3 molecules had a similar distribution in germinal center of lymph nodes, mainly in the cells of paracortical region, the cells in germinal center of lymph follicles and macrophages, etc.
  
  
  CONCLUSIONS
  There are considerably high positive rates of CGRP, ACTH and 5-HT in human peripheral lymph nodes, and their distribution area are basically coincident with that of immunocytes in the lymph nodes.
authors.affiliation: Department of Pathology, Jinnng Medical College, Jining 272013, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wang
authors.forename: Xiang-rui
authors.initials: XR
authors.lastname: Ji
authors.forename: Ji-feng
authors.initials: JF
authors.lastname: Li
authors.forename: Ji-fa
authors.initials: JF
authors.lastname: Gao
authors.forename: Gui-hua
authors.initials: GH
authors.lastname: Liang
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D005260:Female; D018858:Germinal Center / Q000737:chemistry; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry*; D008297:Male; D012701:Serotonin / Q000032:analysis*
chemical_list: D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D015740:Calcitonin Gene-Related Peptide