title: Invasive middle ear cholesterol granuloma involving the basal turn of the cochlea with profound sensorineural hearing loss.
abstract: METHODS
  A retrospective surgical case review.
  
  
  METHODS
  A tertiary-care, university teaching hospital.
  
  
  METHODS
  The authors describe a unique case operated on for a middle ear cholesterol granuloma, which had invaded the cochlea and vestibule causing profound sensorineural deafness.
  
  
  METHODS
  Extended radical mastoidectomy and labyrinthectomy with musculofascial seal.
  
  
  RESULTS
  Successful postoperative outcome with no recurrence seen after 2 years of follow up.
  
  
  CONCLUSIONS
  To the authors' knowledge, this is the first reported case of a primary middle ear cholesterol granuloma with direct invasion into the cochlea. Such invasion of the otic capsule by cholesterol granulomas is rare and presents a diagnostic challenge to the attending otologist and radiologist. Salient points of the case history, pathogenesis, imaging studies, histopathology, and management are presented with a review of the current literature.
authors.affiliation: Tan Tock Seng Hospital, Singapore. emurugasu@ceistanford.com
authors.forename: Euan
authors.initials: E
authors.lastname: Murugasu
authors.forename: Tan Tiong
authors.initials: TT
authors.lastname: Yong
authors.forename: Chong Pek
authors.initials: CP
authors.lastname: Yoon
mesh_terms: D000328:Adult; D002784:Cholesterol; D003051:Cochlea / Q000473:pathology*; D004432:Ear, Middle / Q000473:pathology*; D015745:Granuloma, Foreign-Body / Q000150:complications / Q000601:surgery*; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013506:Otologic Surgical Procedures; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014722:Vestibule, Labyrinth / Q000473:pathology
chemical_list: D002784:Cholesterol