title: Surveillance of susceptibility patterns in 1297 European and US anaerobic and capnophilic isolates to co-amoxiclav and five other antimicrobial agents.
abstract: In vitro susceptibility data were collected for co-amoxiclav and other antimicrobial agents against 1297 recent anaerobe isolates collected in Europe and the USA. The co-amoxiclav (amoxicillin/clavulanic acid) MIC(50/90)s (amoxicillin/clavulanic acid concentration in a ratio of 2:1, expressed in terms of amoxicillin concentration in mg/L) were 0.5/4 for Bacteroides fragilis, </=0.125/1 for Prevotella species, </=0.125/0.25 for Fusobacterium nucleatum, 0.5/1 for Eikenella corrodens, 0.25/8 for Peptostreptococcus anaerobius, </=0.125/0.5 for Micromonas (Peptostreptococcus) micros, </=0.25/0.5 for Fingoldia (Peptostreptococcus) magna, and </=0.125/0.125 for Porphyromonas species. The co-amoxiclav susceptibility rate for B. fragilis was 94.6%, for P. anaerobius 84.3% and for all other species tested 100%. These data indicate that co-amoxiclav remains an effective drug for the antimicrobial treatment and prophylaxis of many anaerobic infections. Among the comparator drugs, metronidazole was very active against all bacterial species (>96% susceptible) except E. corrodens (MIC(50/90) of >32/>64 mg/L), which is a capnophilic organism. Imipenem was also highly active against all species (>98% susceptible). Levofloxacin and clindamycin were the least potent agents tested, particularly against Bacteroides, Prevotella and Peptostreptococcus (levofloxacin susceptibility rates: Bacteroides 72.7%, Prevotella 71.5%, F. magna 72.4%; clindamycin susceptibility rates: Bacteroides 79.5%, Prevotella 92.1%, F. magna 84.7%).
authors.affiliation: Laboratory Specialists, Inc., Cleveland, OH, USA. amdlmk@aol.com
authors.forename: Laura M
authors.initials: LM
authors.lastname: Koeth
authors.forename: Caryn E
authors.initials: CE
authors.lastname: Good
authors.forename: Peter C
authors.initials: PC
authors.lastname: Appelbaum
authors.forename: Ellie J C
authors.initials: EJ
authors.lastname: Goldstein
authors.forename: Arne C
authors.initials: AC
authors.lastname: Rodloff
authors.forename: Marina
authors.initials: M
authors.lastname: Claros
authors.forename: Luc J
authors.initials: LJ
authors.lastname: Dubreuil
mesh_terms: D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000201:enzymology; D001424:Bacterial Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology*; D002245:Carbon Dioxide / Q000378:metabolism; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D011786:Quality Control; D014481:United States / Q000453:epidemiology; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D002245:Carbon Dioxide; D019980:Amoxicillin-Potassium Clavulanate Combination; D001618:beta-Lactamases