[Effect of lanthanum chloride on expressions of collagen protein in a wound tissue].
OBJECTIVE
To evaluate the effect of lanthanum chloride on expressions of collagen protein and find a way to prevent and treat scar.


METHODS
Four linear incisions were made on the dorsal skin of an adult, female Sprague-Dawley rat as an animal model. One was non-manipulated as a control; the second was injected with distilled water as a sham-control; the third was injected with 50 mmol/L of lanthanum chloride, and the fourth was injected with 50 micrograms neutralizing antibody of TGF-beta 1 as a positive control. All of the wound tissues were harvested and assayed with ABC method in 14 days and 28 days after the surgery.


RESULTS
The expressions of type I, III and IV of collagen protein in the third group significantly reduced in 14 and 28 days after the operation, compared with the control or sham-control group. Its values wen as similar as the fourth group.


CONCLUSIONS
Lanthanum chloride could inhibit the expressions of collagen protein, and it may be used to prevent and treat scars.
Zhong
Xiao-chun
XC
Department of Burns and Plastic Surgery, Second People's Hospital of Hangzhou, Hangzhou 310015, China.
Dai
Yu-cheng
YC
Cao
Yong
Y
Li
Guo-hui
GH
Li
Jie
J
Wu
Xie-qing
XQ
Liu
Qiang
Q
D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000187:drug effects*; D005260:Female; D007811:Lanthanum / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014947:Wounds and Injuries / Q000378:metabolism*
C028521:lanthanum chloride; D007811:Lanthanum; D003094:Collagen