Interaction between HIV-1 and HCV infections: towards a new entity?
Since human immunodeficiency virus (HIV) and hepatitis C virus (HCV) share the same modes of transmission, HIV-HCV co-infected patients are relatively common. Until recently, the clinical course of HCV in co-infected patients was overshadowed by the high morbidity and mortality of HIV disease. Recent reductions in morbidity and mortality among HIV-infected patients due to the advent of highly active antiretroviral therapy (HAART), have contributed to the emergence of HCV as a significant viral pathogen in this population. This article reviews the current evidence on the epidemiology and clinical implications of an interaction between HIV-1 and HCV infections.
Winnock
Maria
M
INSERM U593, Université Victor Ségalen, 146 rue Léo Saignat, 33076 Bordeaux, France. Maria.Winnock@isped.u-bordeaux2.fr
Salmon-Céron
Dominique
D
Dabis
François
F
Chêne
Geneviève
G
D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D015497:HIV-1; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D006801:Humans
D019380:Anti-HIV Agents; D000998:Antiviral Agents