Diagnostic microarray: an array of possibilities for parasitology.
Parasites affect a majority of the world's population. Despite this fact, dreams of developing vaccines remain far off. Scientists have long studied gene expression as a hallmark of gene activities reflecting current cell conditions. Analyzing differentially expressed genes is a major initiative, and most labs recoil at the amount of time and high costs required obtaining results. By employing microarrays, researchers can decrease their reliance upon time consuming techniques; consequently, microarray is beginning to dominate other molecular diagnostic technologies. Moreover, the ability of microarrays to monitor simultaneous gene expression of thousands of genes and to produce broad arrays of data has the potential to shift the resources of the scientists from data gathering to analyzing data that are already available. As microarray technology improves and its cost decreases, the role of ability to "see" the molecular biology pathways involved in parasite host relationships will place this technology at the forefront of parasite research.
Fadiel
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Department of ObGyn, Yale University School of Medicine, New Haven, Connecticut 06520-8063, USA. afadiel@yale.edu
Kovac
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Jeffrey
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Morsy
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TA
Helmy
M M F
MM
Naftolin
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F
El Deeb
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HK
D000818:Animals; D020869:Gene Expression Profiling / Q000662:veterinary; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis / Q000662:veterinary; D010272:Parasitic Diseases / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013997:Time Factors