Diacylglycerol's affair with protein kinase C turns 25.
This year marks the 25-year anniversary of the discovery by Nishizuka and co-workers that diacylglycerol activates the ubiquitous signal transducer protein kinase C. This discovery placed the lipid second messenger-protein kinase C signaling pathway center stage alongside the cAMP-protein kinase A pathway, which was already established as a fundamental mechanism for transducing extracellular signals.
Newton
Alexandra C
AC
Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093-0640, USA. anewton@ucsd.edu
D000818:Animals; D004075:Diglycerides / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D011493:Protein Kinase C / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D012106:Research / Q000639:trends; D015290:Second Messenger Systems / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D004075:Diglycerides; D011493:Protein Kinase C