title: Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening.
abstract: OBJECTIVE
  In this study we defined the prevalence of Peyronie's disease in a cohort of men being screened for prostate cancer in the United States. The association between Peyronie's disease, and medical comorbidities and patient self-reported erectile dysfunction was also defined.
  
  
  METHODS
  A total of 534 men presenting to 1 of 3 prostate cancer screening centers provided a complete medical history, underwent physical examination performed in all by a urologist and completed the Sexual Health Inventory for Men (SHIM) questionnaire. This population was chosen because of the access to a large number of subjects combined with the fact that subjects were not presenting with a specific urological complaint. The diagnosis of Peyronie's disease was based on a palpable penile plaque. Data were assessed using univariate analysis, multivariate logistic regression and Pearson chi-square analysis.
  
  
  RESULTS
  A total of 48 patients were found to have a palpable penile plaque on physical examination for a prevalence rate of 8.9%. The mean age of men with Peyronie's disease was 68.2 years compared to a mean of 61.8 years in men without Peyronie's disease (p <0.0001). On univariate analysis hypertension (p = 0.02) and diabetes (p = 0.007) were present with significantly increased frequency in patients with Peyronie's disease. Patients diagnosed with Peyronie's disease had significantly lower values for responses to each of the 5 questions on the SHIM survey. An increase in age and decrease in total SHIM score remained significantly associated with a greater probability of Peyronie's disease on multivariate analysis.
  
  
  CONCLUSIONS
  We found the prevalence of Peyronie's disease to be greater than in most previously reported series. We also noted a significant association between Peyronie's disease aging, hypertension, diabetes and self-reported erectile dysfunction.
authors.affiliation: Department of Urology, Loyola University Medical Center, Maywood, Illinois, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Mulhall
authors.forename: Steven D
authors.initials: SD
authors.lastname: Creech
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boorjian
authors.forename: Sam
authors.initials: S
authors.lastname: Ghaly
authors.forename: Edward D
authors.initials: ED
authors.lastname: Kim
authors.forename: Ayham
authors.initials: A
authors.lastname: Moty
authors.forename: Rodney
authors.initials: R
authors.lastname: Davis
authors.forename: Wayne
authors.initials: W
authors.lastname: Hellstrom
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010411:Penile Induration / Q000150:complications / Q000453:epidemiology*; D010808:Physical Examination; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000150:complications / Q000175:diagnosis