The role of mhc polymorphism in anti-microbial resistance.
The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.
Nikolich-Zugich
Janko
J
Vaccine and Gene Therapy Institute and the Oregon National Primate Research Center of the Oregon Health, Science University, OHSU West Campus, 505 NW 185th Avenue, Beaverton, OR 97006, USA. nikolich@ohsu.edu
Fremont
Daved H
DH
Miley
Michael J
MJ
Messaoudi
Ilhem
I
D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000235:genetics / Q000276:immunology*; D011110:Polymorphism, Genetic
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II