Mass spectrometry and DNA sequencing are complementary techniques for characterizing hemoglobin variants: the example of hemoglobin J-Oxford.
Liquid chromatography-electrospray ionization-mass spectrometry (MS) allows the characterization of most hemoglobin variants and can sometimes be a useful tool to narrow down DNA sequencing analysis. As an example, we report a case of hemoglobin variant J-Oxford, characterized by MS and DNA sequencing analysis.
Caruso
Donatella
D
Crestani
Maurizio
M
Da Riva
Luca
L
Mitro
Nico
N
Giavarini
Flavio
F
Mozzi
Roberta
R
Franzini
Carlo
C
D000328:Adult; D003062:Codon / Q000235:genetics; D005260:Female; D006448:Hemoglobin J / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D009154:Mutation; D017422:Sequence Analysis, DNA; D021241:Spectrometry, Mass, Electrospray Ionization
D003062:Codon; D006448:Hemoglobin J; C042251:hemoglobin I-Interlaken