title: Transcatheter embolization using degradable crosslinked hydrogels.
abstract: Therapeutic embolization is the selective transcatheter blockage of blood vessels or diseased vascular structures. The majority of current embolization materials in clinical use are permanent. There are clinical situations however, in which temporary embolization is desired. Degradable hydroxyethyl acrylate (HEA) microspheres have been synthesized. Canine renal arteries and rabbit central auricular arteries were embolized with HEA microspheres, and compared with degradable human serum albumin (HSA) microspheres, and permanent microspheres. HSA and HEA microspheres both achieved temporary occlusions. HSA and HEA microspheres were recanalizated at 1 and 3 weeks, respectively, while arteries occluded with permanent microspheres did not recanalize. All embolic microspheres led to tissue infarction, with the short-term HSA microspheres providing the least damage, and the permanent microspheres leading to extensive damage. Advantages of temporary embolization were not convincingly demonstrated since temporary occlusions still led to tissue infarction.
authors.affiliation: Biosphere Medical, Inc., 1050 Hingham Street, Rockland, MA 02370, USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schwarz
authors.forename: Hongmin
authors.initials: H
authors.lastname: Zhang
authors.forename: Annick
authors.initials: A
authors.lastname: Metcalfe
authors.forename: Igor
authors.initials: I
authors.lastname: Salazkin
authors.forename: Jean
authors.initials: J
authors.lastname: Raymond
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001158:Arteries / Q000473:pathology* / Q000601:surgery*; D021721:Balloon Occlusion / Q000379:methods*; D001826:Body Fluids / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry; D004285:Dogs; D005026:Ethylene Glycols / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D010316:Particle Size; D011817:Rabbits; D013499:Surface Properties
chemical_list: D003432:Cross-Linking Reagents; D005026:Ethylene Glycols; D020100:Hydrogels; C028001:glycol monoacetate