Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii.
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.
Kopańska
Katarzyna
K
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 5a Pawińskiego, 02-106 Warsaw, Poland.
Najda
Andzelika
A
Zebrowska
Justyna
J
Chomicz
Lidia
L
Piekarczyk
Janusz
J
Myjak
Przemysław
P
Bretner
Maria
M
D000048:Acanthamoeba / Q000187:drug effects*; D000563:Amebicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
D000563:Amebicides; D001562:Benzimidazoles; D014230:Triazoles; C012771:benzotriazole; C031000:benzimidazole