title: End plate marrow changes in the asymptomatic lumbosacral spine: frequency, distribution and correlation with age and degenerative changes.
abstract: OBJECTIVE
  To investigate the frequency and distribution of end plate marrow signal intensity changes in an asymptomatic population and to correlate these findings with patient age and degenerative findings in the spine.
  
  
  METHODS
  MR imaging studies of the lumbosacral (LS) spine in 59 asymptomatic subjects were retrospectively reviewed by 2 musculoskeletal radiologists to determine the presence and location of fat-like and edema-like marrow signal changes about the end plates of the L1-2 through L5-S1 levels. The presence of degenerative changes in the spine was recorded as was patient age. Descriptive statistics were utilized to determine the frequency and associations of end plate findings and degenerative changes in the spine. Interobserver variability was determined by a kappa score. Binomial probability was used to predict the prevalence of the end plate changes in a similar subject population. The Fisher exact test was performed to determine statistical significance of the relationship of end plate changes with degenerative changes in the spine, superior versus inferior location about the disc and age of the patient population.
  
  
  RESULTS
  Focal fat-like signal intensity adjacent to the vertebral end-plate was noted in 15 out of 59 subjects by both readers, and involved 38 and 36 out of 590 end plates by readers 1 and 2, respectively. Focal edema-like signal intensity adjacent to the vertebral end plate was noted in 8 out of 59 subjects by both readers and involved 11 and 10 out of 590 end plates by readers 1 and 2, respectively. Either fat or edema signal intensity occurred most often at the anterior ( p<.05) aspects of the mid-lumbar spine and was seen in an older sub-population of the study ( p<.05).
  
  
  CONCLUSIONS
  End plate marrow signal intensity changes are present in the lumbar spine of some asymptomatic subjects with a characteristic location along the spine and in vertebral end plates.
authors.affiliation: Department of Radiology, VA Healthcare System, 3350 La Jolla Village Drive, La Jolla, CA 92161, USA. cbchung@ucsd.edu
authors.forename: Christine B
authors.initials: CB
authors.lastname: Chung
authors.forename: Bruno C
authors.initials: BC
authors.lastname: Vande Berg
authors.forename: Thierry
authors.initials: T
authors.lastname: Tavernier
authors.forename: Anne
authors.initials: A
authors.lastname: Cotten
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Laredo
authors.forename: Christian
authors.initials: C
authors.lastname: Vallee
authors.forename: Jacques
authors.initials: J
authors.lastname: Malghem
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000473:pathology*; D017116:Low Back Pain / Q000473:pathology*; D008159:Lumbar Vertebrae / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies