title: Placental transmogrification of the lung: clinicopathologic, immunohistochemical and molecular study of two cases, with particular emphasis on the interstitial clear cells.
abstract: Two cases of placental transmogrification of the lung are reported. The lesions presented in the left lung, in one case as a giant bulla of the upper lobe and in the other as a cystic nodule of the lower lobe. A segmentectomy was performed in both cases, and the patients were alive and well 5 years and 2 months after surgery, respectively. In our opinion, pulmonary placental transmogrification is not a variant of emphysema, as generally considered, but rather probably represents a benign proliferation of immature interstitial clear cells with secondary cystic change. This report presents a histological, immunohistochemical, ultrastructural and molecular study of these peculiar cells, together with a review of the literature.
authors.affiliation: Operative Unit of Pathology, S. Maria Nuova Hospital, Reggio Emilia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lantuejoul
authors.forename: Giuliana
authors.initials: G
authors.lastname: Sartori
authors.forename: Nazzarena
authors.initials: N
authors.lastname: Bigiani
authors.forename: Antonio
authors.initials: A
authors.lastname: Maiorana
authors.forename: Gianandrea
authors.initials: G
authors.lastname: Pasquinelli
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Paci
authors.forename: Giulio
authors.initials: G
authors.lastname: Rossi
mesh_terms: D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D019656:Loss of Heterozygosity; D008171:Lung Diseases / Q000235:genetics* / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D018895:Microsatellite Repeats; D008854:Microscopy, Electron; D008875:Middle Aged; D014057:Tomography, X-Ray Computed