title: Rheumatoid arthritis of the cervical spine.
abstract: BACKGROUND
  Rheumatoid arthritis affects over 2 million patients in the United States. It is the most common inflammatory disorder of the cervical spine. The natural history is variable. Women tend to be more commonly involved than men. Atlantoaxial instability is the most common form of cervical involvement and may occur either independently or concomitantly with cranial settling and subaxial instability. Cervical spine involvement can be seen in up to 86% of patients and neurologic involvement in up to 58%. Myelopathy is rare but when present portends a poor prognosis. What is frustrating for clinicians treating these patients is that pain cannot be equated with instability or instability with neurologic symptoms. The goal is to identify patients at risk before the development of neurologic symptoms. Both radiographic and nonradiographic risk factors play an important role in the surgical decision-making process.
  
  
  OBJECTIVE
  We will describe the current concepts in rheumatoid arthritis of the cervical spine. Emphasis is placed on the natural history, anatomy, pathophysiology and decision-making process.
  
  
  METHODS
  A review of the current concepts of rheumatoid arthritis of the cervical spine.
  
  
  METHODS
  MEDLINE search of all English literature published on rheumatoid arthritis of the cervical spine.
  
  
  RESULTS
  Rheumatoid arthritis of the cervical spine was first described by Garrod in 1890. The prevalence has been estimated to be 1% to 2% of the world's adult population. Despite its prevalence, the etiology of rheumatoid arthritis remains unknown. Because of its potentially debilitating and life-threatening sequelae in advanced disease, rheumatoid arthritis in the cervical spine today remains a high priority to diagnose and treat.
  
  
  CONCLUSIONS
  Many aspects of the natural history and pathophysiology of the rheumatoid spine remain unclear. The timing of operative intervention in patients with radiographic instability and no evidence of neurologic deficit is an area of considerable controversy. Continued surveillance into the natural history of the rheumatoid spine is required.
authors.affiliation: Department of Orthopaedics and Rehabilitation, Penn State University, 500 University Drive, Hershey, PA 17036, USA.
authors.forename: Hoan Vu
authors.initials: HV
authors.lastname: Nguyen
authors.forename: Steven C
authors.initials: SC
authors.lastname: Ludwig
authors.forename: Jeffery
authors.initials: J
authors.lastname: Silber
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Gelb
authors.forename: Paul A
authors.initials: PA
authors.lastname: Anderson
authors.forename: Lawrence
authors.initials: L
authors.lastname: Frank
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Vaccaro
mesh_terms: D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001268:Atlanto-Axial Joint; D002574:Cervical Vertebrae / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007593:Joint Instability / Q000473:pathology / Q000503:physiopathology; D008297:Male; D013122:Spinal Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology