title: Regional heterogeneity of cerebral blood flow response to graded pressure-controlled hemorrhage.
abstract: BACKGROUND
  Little is known about the regional distribution of cerebral blood flow (CBF) in nonanesthetized animals during periods of lowered blood pressure. The present investigation addresses the specific reaction patterns of local cerebral blood flow (LCBF) in comparison with mean CBF during graded pressure-controlled hemorrhagic shock in conscious rats.
  
  
  METHODS
  Conscious rats were subjected to graded pressure-controlled hemorrhage (to 85, 70, 55, or 40 mm Hg) by arterial blood withdrawal. After a period of 30 minutes, blood pressure was stabilized by withdrawal or reinfusion of blood. LCBF was determined autoradiographically by the iodo(14C)antipyrine method in 34 brain structures, and mean CBF was calculated and compared with the values of nonhemorrhaged control animals.
  
  
  RESULTS
  Mean CBF remained unchanged except for the group with the lowest blood pressure of 40 mm Hg (decrease in CBF of 28%). Otherwise, LCBF was increased in some brain structures at an unchanged mean CBF. Congruently, at 40 mm Hg, the decrease in mean CBF did not show up in all brain structures, the local pattern of CBF varying between an unchanged and a profoundly decreased CBF. The mean coefficient of variation of CBF was increased with the severity of hemorrhagic shock, which indicates an enhanced heterogeneity of CBF.
  
  
  CONCLUSIONS
  Because of the substantial heterogeneity in the responses of LCBF to pressure-controlled hemorrhage, autoregulation of CBF during pressure-controlled hemorrhagic shock has to be reconsidered on a regional basis.
authors.affiliation: Department of Anesthesiology, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany.
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Waschke
authors.forename: Martin
authors.initials: M
authors.lastname: Riedel
authors.forename: Christian
authors.initials: C
authors.lastname: Lenz
authors.forename: Detlef M
authors.initials: DM
authors.lastname: Albrecht
authors.forename: Klaus
authors.initials: K
authors.lastname: van Ackern
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kuschinsky
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives*; D001345:Autoradiography; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D001931:Brain Mapping; D002250:Carbon Radioisotopes; D006706:Homeostasis / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000502:physiology; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
chemical_list: D002250:Carbon Radioisotopes; D000983:Antipyrine; C008135:iodoantipyrine