Bcl-6 gene mutations in primary cutaneous B-cell lymphomas.
We analyzed mutations in the 5' non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.
Gianelli
Umberto
U
Cerri
Amilcare
A
Cassani
Barbara
B
Moneghini
Laura
L
Raviele
Paola Rafaniello
PR
Berti
Emilio
E
Bosari
Silvano
S
D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*
D020121:5' Untranslated Regions; D051560:Proto-Oncogene Proteins c-bcl-6