Lipid and statin effects on stroke and dementia.
Stroke and dementia are among the leading causes of morbidity and mortality in the elderly. Although elevated cholesterol level has not been a significant risk factor for cerebrovascular disease events, statins produce pleiotropic effects beyond cholesterol lowering and have been shown to reduce major cerebrovascular events, including stroke and transient ischemic attack. This review looks at the effects of this class of agents on major diseases of the central nervous system.
Milani
Richard V
RV
Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA. rmilani@ochsner.org
D003704:Dementia / Q000097:blood / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D020521:Stroke / Q000097:blood / Q000517:prevention & control*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids