Temporal and regional expression of Fos-related proteins in response to ischemic injury.
The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for controlling neuroprotective gene expression. This study characterized the temporal and regional expression of a variety of proteins following ischemic injury induced by occlusion of the middle cerebral artery in rats. The results demonstrated upregulation of both c-Fos and FRA-2 in penumbral regions that preceded upregulation of the classic injury-associated proteins expressed by astrocytes and microglia and, in the case of FRA-2, appeared to correlate with neuronal survival. A further, previously undescribed, expression of FRA-2 in endothelial cells of the core ischemic region was also demonstrated.
Butler
Tanya L
TL
Department of Pharmacology and Therapeutics, University of South Florida, 12901 Bruce B. Downs Boulevard, MDC 9, Tampa, FL 33612, USA.
Pennypacker
Keith R
KR
D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D015415:Biomarkers; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002545:Brain Ischemia / Q000378:metabolism* / Q000503:physiopathology; D002544:Cerebral Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004195:Disease Models, Animal; D018450:Disease Progression; D051921:Fos-Related Antigen-2; D005911:Gliosis / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D020244:Infarction, Middle Cerebral Artery / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D017628:Microglia / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
D015415:Biomarkers; D004268:DNA-Binding Proteins; D051921:Fos-Related Antigen-2; C497874:Fosl2 protein, rat; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors