title: Prognostic indicators in patients with intracranial tuberculoma: a review of 102 cases.
abstract: OBJECTIVE
  To see the characteristics, course and outcome of patients suffering from intracranial tuberculoma.
  
  
  METHODS
  Retrospective review of 102 patients diagnosed as intracranial tuberculoma at a tertiary care center over 10 years.
  
  
  RESULTS
  A total of 102 cases were seen with an age range of 1 to 75 years (mean, 30 years). Predisposing factors included Diabetes mellitus (8 patients) and pregnancy or puerperium (7 patients). Five pediatric patients had tuberculoma despite documented BCG vaccination. Fever (59%), headache (57%), meningeal irritation (36%) were the commonest presenting features; one-third of patients were drowsy or comatosed at presentation. Cerebrospinal fluid analysis was performed in 63 patients, of whom 88% had elevated protein, 83% had low glucose, and 84% had pleocytosis (one-third with neutrophilia). Forty-nine (50%) patients had clinical or laboratory evidence of concomitant tuberculous meningitis. Chest radiographs showed active or old tuberculous infection (25%), with a miliary pattern in 20%. Two-thirds of subjects had multiple tuberculomas (mean, 4.5 lesions per patient) on contrast CT or MRI scan. Hydrocephalus was present in 37 (37%) patients of which 21 required shunt surgery. Thirty-nine patients had > 9 months of follow up; 17 patients showed complete recovery, 20 patients had partial recovery, and 2 patients had no response. Coma at presentation and miliary pattern on chest X-ray were predictors of poor prognosis.
  
  
  CONCLUSIONS
  The study demonstrate that fever, headache, signs of meningeal irritation and cranial nerve palsies are common presenting features. Complete recovery was seen in 40% patients. Coma and military TB are predictors of poor prognosis.
authors.affiliation: Department of Medicine, The Aga Khan University, Karachi.
authors.forename: M
authors.initials: M
authors.lastname: Wasay
authors.forename: M K
authors.initials: MK
authors.lastname: Moolani
authors.forename: J
authors.initials: J
authors.lastname: Zaheer
authors.forename: B A
authors.initials: BA
authors.lastname: Kheleani
authors.forename: R A
authors.initials: RA
authors.lastname: Smego
authors.forename: R A
authors.initials: RA
authors.lastname: Sarwari
authors.forename: A R
authors.initials: AR
authors.lastname: Smego
mesh_terms: D000293:Adolescent; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007538:Isoniazid / Q000627:therapeutic use; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use; D016896:Treatment Outcome; D016862:Tuberculoma, Intracranial / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality
chemical_list: D000904:Antibiotics, Antitubercular; D007538:Isoniazid; D012293:Rifampin