Kikuchi's disease (necrotizing lymphadenitis) with cutaneous involvement associated with subacute cutaneous lupus erythematosus.
Necrotizing histiocytic lymphadenopathy (Kikuchi's disease) is a rarely observed clinical entity characterized by fever, and solitary or multiple lymphadenopathy predominantly in the posterior cervical region. Kikuchi's disease has been reported to precede, coexist with or follow the diagnosis of systemic lupus erythematosus. In only rare instances has its association with cutaneous lupus erythematosus without systemic involvement been reported. We report a 45-year-old woman who presented characteristic systemic and cutaneous manifestations of Kikuchi's disease. Several months later, after sun exposure, she developed lesions of subacute cutaneous lupus erythematosus. The American Rheumatism Association criteria for systemic lupus erythematosus were not fulfilled. The possible pathogenic relationships between the two processes are discussed.
Toll
A
A
Department of Dermatology, Hospital del Mar, Barcelona, Spain.
Gilaberte
M
M
Matias-Guiu
X
X
Camacho
L
L
Alomar
A
A
Gonzalez-Gay
M A
MA
M Pujol
R
R
D005260:Female; D005500:Follow-Up Studies; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000473:pathology; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged