title: [A case of advanced gastric cancer effectively treated by combined chemotherapy of paclitaxel (TXL) and CDDP].
abstract: The patient was a 73-year-old man with unresectable advanced gastric cancer and celiac and supraclavicular lymph node metastases. Neoadjuvant chemotherapy consisting of paclitaxel (TXL) and CDDP was administered. TXL (80 mg/m2) and CDDP (25 mg/m2) was administered weekly on day 1, 8 and 15 as 1 cycle. After 4 cycles of TXL/CDDP administration, the lymph node metastases and gastric tumor had decreased almost completely in size and distal partial gastrectomy was performed. After surgery, the patient was treated with 4 courses of TXL/CDDP and has survived without recurrence to the present. TXL/CDDP is associated with few adverse events in hospital visits, and is thought to be an effective chemotherapy against advanced gastric cancer.
authors.affiliation: Dept. of Surgery I, University of Occupational and Environmental Health, School of Medicine.
authors.forename: Naoki
authors.initials: N
authors.lastname: Nagata
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Inoue
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fukushima
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shibao
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tsurudome
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Higure
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirata
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Kouji
authors.initials: K
authors.lastname: Okamoto
authors.forename: Tetsumi
authors.initials: T
authors.lastname: Konishi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D017239:Paclitaxel; D002945:Cisplatin