title: Cardiac failure in hemolytic uremic syndrome and rescue with extracorporeal life support.
abstract: Extrarenal involvement manifesting in the cardiovascular system is a rare but potentially fatal complication of hemolytic uremic syndrome (HUS). Current treatment is aimed at cardiovascular supportive measures while awaiting organ recovery. However, there are cases in which this recovery never occurs, and patients succumb secondary to heart failure. We report two cases of severe cardiac failure in children in the acute phase of HUS and the use of extracorporeal membrane oxygenation (ECMO) to support one patient to cardiac recovery. Clinicians should be aware of this potentially life-threatening cardiac involvement and should consider the use of ECMO for potentially salvageable children with HUS.
authors.affiliation: Division of Pediatric Critical Care Medicine, Department of Pediatrics and Health Evaluation Sciences, Penn State Children's Hospital, Penn State University College of Medicine, Hershey, PA 17033, USA. nthomas@psu.edu
authors.forename: N J
authors.initials: NJ
authors.lastname: Thomas
authors.forename: J J
authors.initials: JJ
authors.lastname: Messina
authors.forename: W J
authors.initials: WJ
authors.lastname: DeBruin
authors.forename: J A
authors.initials: JA
authors.lastname: Carcillo
mesh_terms: D002675:Child, Preschool; D015199:Extracorporeal Membrane Oxygenation; D017809:Fatal Outcome; D005260:Female; D006333:Heart Failure / Q000209:etiology* / Q000628:therapy*; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006801:Humans; D008297:Male