Profiling natural product biosynthesis.
Natural products are a rich source of therapeutics; however, artificially reengineering the biosynthetic pathways that generate these compounds could potentially generate "designer" drugs. Last month in Chemistry & Biology, Burkart and coworkers reported their technique to track and better understand the components of these pathways.
Frankel
Brenda A
BA
Department of Biochemistry and Biophysics, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
McCafferty
Dewey G
DG
D001685:Biological Factors / Q000096:biosynthesis* / Q000737:chemistry; D018942:Macrolides / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism; D010453:Peptide Synthases / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000378:metabolism*
D001685:Biological Factors; D018942:Macrolides; D009097:Multienzyme Complexes; D010455:Peptides; D010453:Peptide Synthases