title: Is off-pump revascularization better for patients with non-dialysis-dependent renal insufficiency?
abstract: BACKGROUND
  Renal dysfunction is a well-recognized complication following coronary artery bypass grafting (CABG). Coronary revascularization without cardiopulmonary bypass (CPB) has been shown to minimize renal injury in patients with normal preoperative renal function who undergo elective procedures. The purpose of this study was to define the effect of an off-pump revascularization strategy on the incidence of postoperative renal failure and survival of patients with preexisting renal dysfunction.
  
  
  METHODS
  From January 1, 1999, to December 1, 2002, a total of 371 patients were identified as having a preoperative creatinine concentration greater than or equal to 1.5 mg/dL. This number included 291 patients who did not need hemodialysis or peritoneal dialysis to support renal function. These patients were subdivided into those undergoing traditional CABG with CPB (103 patients) and those undergoing off-pump revascularization (188 patients) whose demographic, operative, and outcome information was retrospectively reviewed and compared.
  
  
  RESULTS
  The off-pump cohort was older than the on-pump cohort (70 +/- 9.6 versus 66 +/- 10.9 years; P =.002), had a lower prevalence of previous myocardial infarction (35% versus 50%; P =.008), and had a modestly higher mean left ventricular ejection fraction (0.47 +/- 0.01 versus 0.43 +/- 0.01; P =.017). Otherwise the groups were well matched. The mean preoperative serum creatinine and creatinine clearance values were not significantly different (1.8 +/- 0.5 versus 1.9 +/- 0.6 mg/dL [ P =.372] and 45.1 +/- 15.5 versus 46.8 +/- 17.2 mL/min [ P =.376] for the off-pump and on-pump cohorts, respectively). There was a significant reduction in postoperative renal failure (17% versus 9% of patients; P =.020) and need for new dialysis (10% versus 3% of patients; P =.022) when CPB was eliminated. Intermediate-term survival analysis revealed a survival benefit for the off-pump group (70% versus 57%) at 42 months, although this value did not reach statistical significance ( P =.143).
  
  
  CONCLUSIONS
  The results of this study suggested that patients with preoperative non-dialysis-dependent renal insufficiency have more favorable outcome when revascularization is done off pump. Avoidance of CPB results in (1) a reduction in the incidence of postoperative renal failure; (2) a reduction in the need for new dialysis; and (3) improved in-hospital and midterm survival.
authors.affiliation: Departments of Cardiothoracic Surgery, Newark Beth Israel Medical Center, USA. dgoldstein@sbhcs.com
authors.forename: Robert B
authors.initials: RB
authors.lastname: Beauford
authors.forename: Craig R
authors.initials: CR
authors.lastname: Saunders
authors.forename: Leo A
authors.initials: LA
authors.lastname: Niemeier
authors.forename: Troy Adam
authors.initials: TA
authors.lastname: Lunceford
authors.forename: Ravindra
authors.initials: R
authors.lastname: Karanam
authors.forename: Thomas
authors.initials: T
authors.lastname: Prendergast
authors.forename: Shamji
authors.initials: S
authors.lastname: Shah
authors.forename: Paul
authors.initials: P
authors.lastname: Burns
authors.forename: Frederick
authors.initials: F
authors.lastname: Sardari
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Goldstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D047549:Coronary Artery Bypass, Off-Pump / Q000401:mortality* / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D006435:Renal Dialysis / Q000401:mortality* / Q000706:statistics & numerical data*; D051437:Renal Insufficiency / Q000401:mortality*; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome