Epigenetic regulation of tumor suppressors in t(8:21)-containing AML.
The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.
Yang
G
G
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Khalaf
W
W
van de Locht
L
L
Jansen
J H
JH
van der Reijden
B A
BA
Müller-Tidow
C
C
Delwel
H Ruud
HR
Serve
H
H
Clapp
D W
DW
Hiebert
S W
SW
D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*