title: Diagnostic accuracy of fine-needle aspiration cytology and frozen section in primary parotid carcinoma.
abstract: BACKGROUND
  The low incidence and histologic heterogeneity of primary parotid carcinomas makes it difficult to evaluate the value of preoperative fine-needle aspiration cytology (FNAC) and intraoperative frozen section (FS) analysis. In the current study, the authors reviewed a single institution's experience regarding the preoperative and intraoperative diagnostic value of FNAC and FS in primary salivary gland carcinomas.
  
  
  METHODS
  Between January 1990 and December 2002, 108 primary parotid carcinomas were resected at the Department of Otorhinolaryngology, Head and Neck Surgery at the University of Berne, Inselspital (Berne, Switzerland). Included in the study were a total of 101 carcinomas with preoperative FNAC results in 88 tumors and/or intraoperative FS results in 45 tumors. In a retrospective study, the results of FNAC and FS were analyzed and compared with the corresponding histopathologic diagnoses.
  
  
  RESULTS
  The cytologic findings were true-positive for malignancy in 63 tumors (72%), false-negative in 22 tumors (25%), and nondiagnostic in 3 tumors (3%). The tumor grading was correct in 29 of 63 tumors (46%), and the exact tumor typing was correct in 27 of 63 (43%) true-positive tumors. The FS findings were true-positive for malignancy in 43 of 45 tumors (96%), the tumor grading was correct in 35 of 45 tumors (78%), and the tumor typing was correct in 32 of 45 tumors (71%). Overall, at the time of surgery, of the 101 parotid carcinomas, the tumor was known to be malignant in 83 tumors (82%), and the correct grade and the exact tumor type were known in 55 tumors (54%) and 48 tumors (48%), respectively.
  
  
  CONCLUSIONS
  FNAC recognized malignancy in 72% of tumors, but it could not be relied upon to provide an accurate tumor grading or typing. Therefore, FNAC alone is not prone to determine the surgical management of primary parotid carcinomas. The current analysis showed the statistically significant superiority of FS compared with FNAC regarding the diagnosis of malignancy, tumor grading, and tumor typing in primary parotid carcinomas.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Berne, Inselspital, Berne, Switzerland. peter.zbaeren@insel.ch
authors.forename: Peter
authors.initials: P
authors.lastname: Zbären
authors.forename: Michel
authors.initials: M
authors.lastname: Nuyens
authors.forename: Heinz
authors.initials: H
authors.lastname: Loosli
authors.forename: Edouard
authors.initials: E
authors.lastname: Stauffer
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D003581:Cytodiagnosis; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D010307:Parotid Neoplasms / Q000473:pathology* / Q000601:surgery; D011300:Preoperative Care; D012189:Retrospective Studies; D012680:Sensitivity and Specificity