Rapid determination of telmisartan in pharmaceutical preparations and serum by linear sweep polarography.
The polarographic behaviors of telmisartan (TE) are investigated in 0.8 mol/l NH3.H2O-NH4Cl (pH = 8.9) supporting electrolyte. The results demonstrated that the reduction peak is obtained at ca. -1.30V, which corresponds to a catalytic hydrogen wave. Based on the catalytic hydrogen wave, a novel method has been developed for the determination of telmisartan by linear sweep polarography. Calibration curve is linear in the range 2.0 x 10(-7) to 3.0 x 10(-6) mol/l and the detection limit is 1.0 x 10(-7) mol/l. The proposed method is applied to the rapid determination of the telmisartan in capsule forms and biological sample without pre-separation.
Xu
Maotian
M
Institute of Analytical Science, Northwest University, Xi'an 710069, PR China.
Song
Junfeng
J
Liang
Yaodong
Y
D001562:Benzimidazoles / Q000032:analysis / Q000097:blood* / Q000737:chemistry; D001565:Benzoates / Q000032:analysis / Q000097:blood* / Q000737:chemistry; D006801:Humans; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000097:blood / Q000737:chemistry; D011048:Polarography / Q000379:methods*; D000077333:Telmisartan
D001562:Benzimidazoles; D001565:Benzoates; D004364:Pharmaceutical Preparations; D000077333:Telmisartan