Another patient with chromosome 18 deletion syndrome and juvenile rheumatoid arthritis.
Previously, 4 children with deletion of the long arm of chromosome 18 and chronic arthritis were reported. We present an 8-year-old girl with arthritis, atrial septal defect, external auditory canal atresia, and developmental delay. She is the fifth child reported with 18q- syndrome and juvenile rheumatoid arthritis. Evidence is mounting that genetic loci on chromosome 18 may play a role in the expression of complex autoimmune diseases. Idiopathic arthritis should be considered as a potential additional feature in 18q- syndrome.
Rosen
Paul
P
Division of Rheumatology, Children's Hospital of Pittsburgh, Pittsburgh, PA 15213, USA. Paul.Rosen@chp.edu
Hopkin
Robert J
RJ
Glass
David N
DN
Graham
T Brent
TB
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000188:drug therapy / Q000235:genetics*; D002648:Child; D002871:Chromosome Banding; D002872:Chromosome Deletion; D025063:Chromosome Disorders / Q000235:genetics* / Q000473:pathology; D002887:Chromosomes, Human, Pair 18; D002658:Developmental Disabilities; D004424:Ear Canal / Q000002:abnormalities / Q000601:surgery; D019066:Facies; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000235:genetics / Q000473:pathology / Q000601:surgery; D006801:Humans; D009288:Naproxen / Q000627:therapeutic use; D013577:Syndrome; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen