Effect of purine-free low-malt liquor (happo-shu) on the plasma concentrations and urinary excretion of purine bases and uridine--comparison between purine-free and regular happo-shu.
To determine whether purine-free and regular low-malt liquor beverages (happo-shu) increase the plasma concentration and urinary excretion of purine bases (hypoxanthine, xanthine, uric acid) and uridine, 6 healthy males were given regular (10 ml/kg of body weight) and purine-free happo-shu (10 ml/kg of body weight). Plasma concentration-time curves were plotted, and the areas under the curves for uric acid and total purine bases (the sum of hypoxanthine, xanthine, and uric acid) were greater in the regular than in the purine-free happo-shu ingestion experiment (both p < 0.05). In addition, the total urinary excretion of xanthine, total purine bases, and uridine was greater in the regular than in the purine-free happo-shu ingestion experiment (p < 0.05 in all cases), although the total urinary excretion of hypoxanthine and uric acid was no different between the regular and the purine-free happo-shu ingestion experiments. These results suggest that uridine contained in regular happo-shu might contribute to an increase in the urinary excretion of uridine along with ethanol, and that the purines contained in regular happo-shu may contribute to the increase in plasma concentration of uric acid due to purine degradation.
Yamamoto
T
T
Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. tetsuya@hyo-med.ac.jp
Moriwaki
Y
Y
Ka
T
T
Inokuchi
T
T
Takahashi
S
S
Tsutsumi
Z
Z
Fukuchi
M
M
Hada
T
T
D000328:Adult; D001515:Beer; D002492:Central Nervous System Depressants / Q000097:blood / Q000493:pharmacokinetics; D003404:Creatinine / Q000097:blood / Q000652:urine; D002523:Edible Grain; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D011687:Purines / Q000097:blood* / Q000652:urine*; D011743:Pyrimidines / Q000097:blood / Q000652:urine; D019289:Pyruvic Acid / Q000097:blood; D014527:Uric Acid / Q000097:blood / Q000652:urine; D014529:Uridine / Q000097:blood* / Q000652:urine*
D002492:Central Nervous System Depressants; D011687:Purines; D011743:Pyrimidines; D014527:Uric Acid; D019344:Lactic Acid; D000431:Ethanol; D019289:Pyruvic Acid; D003404:Creatinine; D014529:Uridine