title: Correlation between temporal response of fMRI and fast reaction time in a language task.
abstract: Correlation between behavioral parameters and fMRI responses can provide an advanced understanding of the neuronal processes. A lexical decision task was employed to examine the correlation between the reaction time (RT) and the temporal parameters in event-related BOLD responses. Word frequency was manipulated in the experiment. RTs for high-frequency, low-frequency and pseudowords were measured during fMRI (417 +/- 9 ms, 631 +/- 22 ms and 658 +/- 15 ms, respectively). For high-frequency words, RTs were significantly shorter than that for low-frequency and pseudowords (p < 0.0005). In the left inferior frontal region, the FWHM of the fMRI responses was significantly correlated with RT (p < 0.001), which may correspond to areas with sustained activation during the whole processing.
authors.affiliation: MRI Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan. hlaliu@mail.cgu.edu.tw
authors.forename: Ho-Ling
authors.initials: HL
authors.lastname: Liu
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Liao
authors.forename: Shin-Yi
authors.initials: SY
authors.lastname: Fang
authors.forename: Tieh-Chi
authors.initials: TC
authors.lastname: Chu
authors.forename: Li Hai
authors.initials: LH
authors.lastname: Tan
mesh_terms: D000328:Adult; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology; D011930:Reaction Time / Q000502:physiology*; D013067:Speech Perception / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology*; D014705:Verbal Behavior / Q000502:physiology*; D014706:Verbal Learning / Q000502:physiology*