title: Orthogonal base pairs continue to evolve.
abstract: Recent developments in the design and construction of unusual analogs of the natural nucleic acid bases have reached a milestone with the report (in this issue of Chemistry & Biology) of a new orthogonal base pair that allows site-specific introduction of a photo-crosslinkable modified base into an RNA molecule by T7 RNA polymerase-mediated transcription of DNA containing the base-pairing partner.
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Bergstrom
mesh_terms: D020029:Base Pairing; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000378:metabolism; D003596:Cytosine / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D006147:Guanine / Q000737:chemistry / Q000378:metabolism; D009696:Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D011687:Purines / Q000378:metabolism; D011725:Pyridines / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic; D014764:Viral Proteins
chemical_list: D003432:Cross-Linking Reagents; D009696:Nucleic Acids; D011687:Purines; D011725:Pyridines; D014764:Viral Proteins; D006147:Guanine; D012313:RNA; D003596:Cytosine; D004247:DNA; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases