Optimisation of powders for pulmonary delivery using supercritical fluid technology.
Supercritical fluid technology exploited in this work afforded single-step production of respirable particles of terbutaline sulphate (TBS). Different crystal forms of TBS were produced consistently, including two polymorphs, a stoichiometric monohydrate and amorphous material as well as particles with different degrees of crystallinity, size, and morphology. Different solid-state and surface characterisation techniques were applied in conjunction with measurements of powder flow properties using AeroFlow device and aerosol performance by Andersen Cascade Impactor tests. Improved fine particle fraction (FPF) was demonstrated for some powders produced by the SCF process when compared to the micronised material. Such enhanced flow properties and dispersion correlated well with the reduced surface energy parameters demonstrated by these powders. It is shown that semi-crystalline particles exhibited lower specific surface energy leading to a better performance in the powder flow and aerosol tests than crystalline materials. This difference of the surface and bulk crystal structure for selected powder batches is explained by the mechanism of precipitation in SCF which can lead to surface conditioning of particles produced.
Rehman
Mahboob
M
Nektar Therapeutics UK Limited, 69 Listerhills Science Park, Campus Road, Bradford BD7 1HR, UK. mrehman@uk.nektar.com
Shekunov
Boris Y
BY
York
Peter
P
Lechuga-Ballesteros
David
D
Miller
Danforth P
DP
Tan
Trixie
T
Colthorpe
Paul
P
D000280:Administration, Inhalation; D000336:Aerosols; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D016503:Drug Delivery Systems / Q000379:methods*; D008168:Lung; D010316:Particle Size; D011208:Powders; D013499:Surface Properties; D013678:Technology, Pharmaceutical; D013726:Terbutaline / Q000008:administration & dosage / Q000737:chemistry*; D013997:Time Factors
D000336:Aerosols; D001993:Bronchodilator Agents; D011208:Powders; D013726:Terbutaline