Rhabdomyolysis after the administration of itraconazole to an asthmatic patient with bronchopulmonary aspergillosis.
It is known that the coadministration of itraconazole with cholesterol-lowering statins may induce muscle damage. We describe the case of a patient with steroid-dependent asthma, steroid-induced severe myopathy and allergic bronchopulmonary aspergillosis who developed rhabdomyolysis and acute renal failure following a approximately 6-week treatment with itraconazole, even without the concomitant use of HMG-CoA reductase inhibitors.
Ferrari
Marcello
M
Dipartimento di Scienze Biomediche e Chirurgiche, Servizio di Fisiopatologia Respiratoria, Università di Verona, Italy. ferrari@medicinad.univr.it
Bodini
Ilaria
I
Lo Cascio
Vincenzo
V
D058186:Acute Kidney Injury / Q000139:chemically induced; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects*; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000188:drug therapy* / Q000209:etiology; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000139:chemically induced*
D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D017964:Itraconazole