title: Sagittal laser optical tomography for imaging of rheumatoid finger joints.
abstract: We present a novel optical tomographic imaging system that was designed to determine two-dimensional spatial distribution of optical properties in a sagittal plane through finger joints. The system incorporates a single laser diode and a single silicon photodetector into a scanning device that records spatially resolved light intensities as they are transmitted through a finger. These data are input to a model-based iterative image reconstruction (MOBIIR) scheme, which uses the equation of radiative transfer (ERT) as a forward model for light propagation through tissue. We have used this system to obtain tomographic images of six proximal interphalangeal finger joints from two patients with rheumatoid arthritis. The optical images were compared to clinical symptoms and ultrasound images.
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. ahh2004@columbia.edu
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Hielscher
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Klose
authors.forename: Alexander K
authors.initials: AK
authors.lastname: Scheel
authors.forename: Bryte
authors.initials: B
authors.lastname: Moa-Anderson
authors.forename: Marina
authors.initials: M
authors.lastname: Backhaus
authors.forename: Uwe
authors.initials: U
authors.lastname: Netz
authors.forename: Jürgen
authors.initials: J
authors.lastname: Beuthan
mesh_terms: D000465:Algorithms; D019412:Anatomy, Cross-Sectional / Q000379:methods*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000473:pathology*; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007834:Lasers; D012720:Severity of Illness Index; D041622:Tomography, Optical / Q000379:methods*; D014463:Ultrasonography