Nonparaneoplastic limbic encephalitis with relapsing polychondritis.
Relapsing polychondritis (RP), which shows pain, swelling and destruction of the affected parts, is a rare autoimmune disorder affecting cartilage. We report a patient with RP that affected skull cartilage, who subsequently developed multifocal meningoencephalitis. The patient presented with severe recent memory disturbance, anxiety and moderate depression. MRI study showed bilateral median temporal lobe lesions including hippocampi and amygdaloidal bodies, abnormal findings that disappeared after treatment with high-dose steroids. This is thought to be the first case of RP presenting amnesic syndrome and mental disorder associated with nonparaneoplastic limbic encephalitis involving bilateral hippocampi and amygdaloidal bodies detected by MRI.
Ohta
Yasuyuki
Y
Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. yasuyuki@cc.okayama-u.ac.jp
Nagano
Isao
I
Niiya
Daigo
D
Fujioka
Hideki
H
Kishimoto
Takumi
T
Shoji
Mikio
M
Abe
Koji
K
D001007:Anxiety / Q000188:drug therapy / Q000209:etiology; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D020363:Limbic Encephalitis / Q000150:complications* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology; D008875:Middle Aged; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids