title: Antinucleosome antibodies may help predict development of systemic lupus erythematosus in patients with primary antiphospholipid syndrome.
abstract: Patients with primary antiphospholipid syndrome (PAPS) may evolve to systemic lupus erythematosus (SLE), even many years later. This makes differentiation between primary and secondary antiphospholipid syndrome a difficult task. Studies in murine models of lupus have shown that the development of antinucleosome (anti-NCS) antibodies may occur from the early stages of life. We therefore hypothesize that anti-NCS antibodies could help predict development of SLE in patients with PAPS. We studied anti-NCS antibodies in 18 PAPS patients (15 female, three male), followed for a mean of 11 years to evaluate the potential development of SLE. When PAPS was diagnosed, nine patients were positive for anti-NCS antibodies. Six of them developed clinical manifestations of SLE. In contrast, none of the patients who were negative to anti-NCS antibodies developed it. These findings suggest that anti-NCS antibodies could help predict which patients with PAPS may eventually develop SLE.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Abraham Simón
authors.forename: J
authors.initials: J
authors.lastname: Rojas-Serrano
authors.forename: J
authors.initials: J
authors.lastname: Cabiedes
authors.forename: J
authors.initials: J
authors.lastname: Alcocer-Varela
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017153:Antibodies, Anticardiolipin / Q000032:analysis / Q000378:metabolism*; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D015984:Causality; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011237:Predictive Value of Tests; D011336:Probability; D018570:Risk Assessment; D017678:Sex Distribution; D018709:Statistics, Nonparametric
chemical_list: D017153:Antibodies, Anticardiolipin; D015415:Biomarkers