[Comparative studies on pharmacological effects of angong niuhuang pill with its simplified prescicription].
OBJECTIVE
Based on the therapeutic claims of Angong Niuhuang pill, a series of pharmacodynamic experiments were designed, where pharmacological effects were investigated comparatively with its simplified prescription(realgar and cinnabar are removed from the original pill) as a parallel control in order to explore possible contribution of cinnabar and realgar to pharmacodynamic activities of the pill as a whole.


METHODS
Anti-pyretic, sedative, anti-convulsive, and mice-protected effects of the pill and its simplified prescription as a control were observed, respectively, in rabbits with fever induced by typhoid bacillus, in pentobarbital sodium-induced sleeping mice, in mice with convulsion induced by strychnine, or pentylenetetrazole, and in mice with anoxia induced by NaNO2.


RESULTS
Both the pill and its simplified prescription were found to have Anti-pyretic action and protective effect against the mouse death induced by anoxia, and synergistic interaction with pentobarbital sodium in sedative activity, although neither of them was found to have any effects on the convulsion of mice.


CONCLUSIONS
No significant difference between Angong Niuhuang pill and its simplified prescription was found in the above pharmacodynamic experiments.
Ye
Zu-guang
ZG
Institute of Chinese Materia Medica, Chinese Academy of Traditional Chinese Medicine, Beijing 100700, China.
Wang
Jin-hua
JH
Liang
Ai-hua
AH
Xue
Bao-yun
BY
Wang
Yue-sheng
YS
Wang
Zhi-min
ZM
Wang
Lan
L
Li
Chun-ying
CY
Zhang
Jing
J
Huang
Ning
N
Jin
Ai-ying
AY
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001152:Arsenicals / Q000494:pharmacology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D017669:Mercury Compounds / Q000494:pharmacology; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D013440:Sulfides / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D000927:Anticonvulsants; D001152:Arsenicals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D008419:Materia Medica; D017669:Mercury Compounds; D013440:Sulfides; C058317:arsenic disulfide; C034211:cinnabar