Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction.
This study was performed to investigate the serum levels of bisphenol A (BPA), an endocrine disruptor, in women with ovarian dysfunction and obesity. Fasting serum samples were obtained from 19 non-obese and 7 obese women with normal menstrual cycles: 7 patients with hyperprolactinemia, 21 patients with hypothalamic amenorrhea, and 13 non-obese and 6 obese patients with polycystic ovary syndrome (PCOS). BPA was measured by an enzyme-linked immunosorbent assay. BPA was detected in all human sera. Serum BPA concentrations were significantly higher in both non-obese and obese women with polycystic ovary syndrome (1.05 +/- 0.10 ng/ml, 1.17 +/- 0.16 ng/ml; p<0.05, respectively) and obese normal women (1.04 +/- 0.09 ng/ml, p<0.05) compared with those in non-obese normal women (0.71 +/- 0.09 ng/ml). There was no difference among women with hyperprolactinemia, women with hypothalamic amenorrhea, and non-obese normal women. There were significant positive correlations between serum BPA and total testosterone (r = 0.391, p<0.001), free testosterone (r = 0.504, p<0.001), androstenedione (r = 0.684, p<0.001), and DHEAS (r = 0.514, p<0.001) concentrations in all subjects. These findings show that there is a strong relationship between serum BPA and androgen concentrations, speculatively due to the effect of androgen on the metabolism of BPA.
Takeuchi
Toru
T
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan.
Tsutsumi
Osamu
O
Ikezuki
Yumiko
Y
Takai
Yasushi
Y
Taketani
Yuji
Y
D000726:Androgen Antagonists / Q000097:blood* / Q000494:pharmacology*; D000735:Androstenedione / Q000097:blood; D001559:Benzhydryl Compounds; D016022:Case-Control Studies; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004702:Endocrine Glands / Q000187:drug effects*; D005260:Female; D006801:Humans; D009765:Obesity / Q000150:complications; D009994:Osmolar Concentration; D010636:Phenols / Q000097:blood* / Q000494:pharmacology*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D013739:Testosterone / Q000097:blood; D000098826:Bisphenol A Compounds
D000726:Androgen Antagonists; D000735:Androstenedione; D001559:Benzhydryl Compounds; D019314:Dehydroepiandrosterone Sulfate; D010636:Phenols; D013739:Testosterone; C006780:bisphenol A; D000098826:Bisphenol A Compounds