title: Protein kinase C family functions in B-cell activation.
abstract: Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activation and B-cell survival. Recent evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCdelta is specifically required to maintain the tolerance of self-reactive B cells.
authors.affiliation: Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA.
authors.forename: Beichu
authors.initials: B
authors.lastname: Guo
authors.forename: Thomas T
authors.initials: TT
authors.lastname: Su
authors.forename: David J
authors.initials: DJ
authors.lastname: Rawlings
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002470:Cell Survival / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D021962:Membrane Microdomains / Q000276:immunology; D051379:Mice; D011493:Protein Kinase C / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D011947:Receptors, Antigen, B-Cell; D011493:Protein Kinase C