title: Diagnostic interview assessed neuropsychiatric disorder comorbidity in 334 individuals with obsessive-compulsive disorder.
abstract: Is obsessive-compulsive disorder (OCD) a discrete disorder? Three hundred thirty-four individuals with OCD were interviewed using the Structured Clinical Interview for DSM (SCID). Results demonstrate that OCD is highly comorbid with other neuropsychiatric disorders, with 92% of OCD study participants receiving one or more additional Axis I DSM diagnoses. Among these additional diagnoses, lifetime mood disorders (81%) and anxiety disorders (53%) were the most prevalent. With the exception of substance-related disorders and specific phobias, all disorders assessed were found in considerably higher frequency than in the general population, indicating that OCD is associated with highly complex comorbidity. These data have implications for genetic studies of OCD and disorders related to OCD, as well as for specific psychotherapeutic and psychopharmacologic interventions.
authors.affiliation: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland, 20892, USA. lasallev@intra.nimh.nih.gov
authors.forename: V Holland
authors.initials: VH
authors.lastname: LaSalle
authors.forename: Kiara R
authors.initials: KR
authors.lastname: Cromer
authors.forename: Kathryn N
authors.initials: KN
authors.lastname: Nelson
authors.forename: Diane
authors.initials: D
authors.lastname: Kazuba
authors.forename: Lucy
authors.initials: L
authors.lastname: Justement
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Murphy
mesh_terms: D000328:Adult; D015897:Comorbidity; D039721:Diagnostic and Statistical Manual of Mental Disorders; D007174:Disruptive, Impulse Control, and Conduct Disorders; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D015995:Prevalence; D012737:Sex Factors; D016896:Treatment Outcome