title: Computed tomography sound velocity reconstruction using incomplete data.
abstract: An approach based on limited-angle transmission tomography for reconstruction of the sound velocity distribution in the breast is proposed. The imaging setup is similar to that of x-ray mammography. With this setup, the time-of-flight data are acquired by a linear array positioned at the top of the compressed breast that both transmits and receives, and a metal plate is placed at the bottom as a reflector. The setup allows acoustic data acquisition for simultaneous B-mode image formation and the tomographic sound velocity reconstruction. In order to improve the sound velocity estimation accuracy, a new reconstruction algorithm based on a convex programming formulation has been developed. Extensive simulations for both imaging and time-of-flight data based on a 5-MHz linear array were performed on tissues with different geometries and acoustic parameters. Results show that the sound velocity error was generally 1-3 m/s, with a maximum of 5.8 m/s. The radii of the objects under investigation varied from 2 to 6 mm, and all of them were detected successfully. Thus, the proposed approach has been shown to be both feasible and accurate. The approach can be used to complement conventional B-mode imaging to further enhance the detection of breast cancer.
authors.affiliation: Department of Electrical Engineering, National Taiwan University, Taipei.
authors.forename: Sheng-Wen
authors.initials: SW
authors.lastname: Huang
authors.forename: Pai-Chi
authors.initials: PC
authors.lastname: Li
mesh_terms: D000465:Algorithms; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods; D016217:Ultrasonography, Mammary / Q000295:instrumentation* / Q000379:methods*