title: Measurement error of two different techniques for brain atrophy assessment in multiple sclerosis.
abstract: The measurement errors associated with two techniques for brain atrophy assessment in multiple sclerosis (MS) were estimated. The measurement error of a semiautomated, nonnormalized technique with partial brain coverage was about twofold higher than that of a fully automated, normalized technique with full brain coverage (Structural Image Evaluation of Normalized Atrophy software [SIENA]). As shown by the analysis of data from a clinical trial of glatiramer acetate, the use of SIENA increases the study power to detect a treatment effect on brain volume changes in MS patients.
authors.affiliation: Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Sormani
authors.forename: M
authors.initials: M
authors.lastname: Rovaris
authors.forename: P
authors.initials: P
authors.lastname: Valsasina
authors.forename: J S
authors.initials: JS
authors.lastname: Wolinsky
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D001284:Atrophy / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D004311:Double-Blind Method; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data*; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy; D010455:Peptides / Q000627:therapeutic use; D011237:Predictive Value of Tests; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic / Q000379:methods
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate