title: Stroke and elevated blood flow velocity in the anterior cerebral artery in sickle cell disease.
abstract: Transcranial Doppler ultrasonography provides a noninvasive method of predicting stroke risk in children with sickle cell disease. Elevated cerebral blood flow velocity in the terminal internal carotid or middle cerebral artery is associated with an increased stroke risk, but the clinical significance of elevated velocities in the other large intracranial vessels is unknown. The authors report stroke in two children with sickle cell disease and high blood flow velocity limited to the anterior cerebral artery. This suggests that elevated velocity in this vessel may be associated with an increased risk of stroke.
authors.affiliation: Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA. kwiatkowski@email.chop.edu
authors.forename: Janet L
authors.initials: JL
authors.lastname: Kwiatkowski
authors.forename: Robert
authors.initials: R
authors.lastname: Zimmerman
authors.forename: Barbara
authors.initials: B
authors.lastname: Greenbaum
authors.forename: Kwaku
authors.initials: K
authors.lastname: Ohene-Frempong
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications*; D020771:Anterior Cerebral Artery / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology*; D002533:Cerebral Angiography; D002675:Child, Preschool; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D020521:Stroke / Q000209:etiology* / Q000503:physiopathology; D017585:Ultrasonography, Doppler, Transcranial