title: Effect of statins, smoking and obesity on progression of monoclonal gammopathy of undetermined significance: a case-control study.
abstract: Interleukin-6 (IL-6) and C-reactive protein (CRP, a surrogate marker for IL-6) are important in monoclonal gammopathy of undetermined significance (MGUS) and myeloma. Smoking and obesity may elevate CRP levels, while statins decrease CRP levels. A case-control study in 200 MGUS patients found that statin use, smoking history and obesity do not affect MGUS progression.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Thompson
authors.forename: Robert A
authors.initials: RA
authors.lastname: Kyle
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Melton
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Plevak
authors.forename: S Vincent
authors.initials: SV
authors.lastname: Rajkumar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D016022:Case-Control Studies; D018450:Disease Progression; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D010265:Paraproteinemias / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors