New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. II. Structure elucidation.
The structures of beauvericins D, E and F, novel potentiators of miconazole activity against Candida albicans produced by Beauveria sp. FKI 1366, were elucidated by various spectroscopic analyses including UV, NMR, and MS and degradation experiments. They have the common skeleton of the 18-membered cyclodepsipeptides.
Fukuda
Takashi
T
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Arai
Masayoshi
M
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000596:Amino Acids / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D004357:Drug Synergism; D006868:Hydrolysis; D018942:Macrolides / Q000737:chemistry*; D008825:Miconazole / Q000494:pharmacology; D008968:Molecular Conformation; D009904:Optical Rotation; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D000935:Antifungal Agents; D047630:Depsipeptides; D018942:Macrolides; C485086:beauvericin D; C485087:beauvericin E; C485088:beauvericin F; D008825:Miconazole