Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202.
Two novel human leukocyte antigen (HLA) class II alleles for DRB3 and DQB1 genes detected in Caucasoid Spanish individuals are described: DRB3*0218 and DQB1*030202. Both alleles have been found during routine high-resolution typing by sequencing. DRB3*0218 shows a novel DRB3 gene polymorphic position, located at amino acid residue 58, alanine to glutamic acid. This residue is shared by several DRB1 alleles, including all described DRB1*11 subtypes. DQB1*030202 differs from DQB1*030201 by a point mutation at position 319 (T to C). This nucleotide change generates a new codon at amino acid position 75 that is not shared by any other DQB1 allele.
Balas
A
A
Histocompatibility Department, Regional Transfusion Center of Madrid, Madrid, Spain. abalas.trans@salud.madrid.org
Aviles
M J
MJ
Lillo
R
R
Alonso-Nieto
M
M
Zarapuz
L
L
García-Villaescusa
R
R
García-Sánchez
F
F
Vicario
J L
JL
D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059826:HLA-DRB3 Chains; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059826:HLA-DRB3 Chains; C495082:HLA-DRB3*02:18 antigen