ICM0301s, new angiogenesis inhibitors from Aspergillus sp. F-1491. II. Physico-chemical properties and structure elucidation.
ICM0301A (1), B (2) and their congeners (3 approximately 8) were isolated from a culture broth of Aspergillus sp. F-1491 as new angiogenesis inhibitors. Their structures were elucidated by spectroscopic analyses. ICM0301A and B have a substituted decalin skeleton containing two oxirane rings.
Someno
Tetsuya
T
Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. numazu@bikaken.or.jp
Kumagai
Hiroyuki
H
Ohba
Shun-ichi
S
Amemiya
Masahide
M
Naganawa
Hiroshi
H
Ishizuka
Masaaki
M
Ikeda
Daishiro
D
D020533:Angiogenesis Inhibitors / Q000737:chemistry*; D001230:Aspergillus / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004852:Epoxy Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D020533:Angiogenesis Inhibitors; D004852:Epoxy Compounds; D009281:Naphthalenes