Metallic tin is an adjuvant for anaphylaxis in rats.
Metallic tin powder is known to have an adjuvant-like property, by which it increases the levels of natural antibodies and induced hemagglutinins, and it enhances the induction of allergic encephalomyelitis in rats. In the present work, metallic tin is shown to be an adjuvant for a different immunologic process, anaphylactic sensitization. The new data support the notion that metallic tin causes polyclonal B-cell activation with proliferation of plasma cells.
Levine
Seymour
S
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. Levines@nki.rfmh.org
Saltzman
Arthur
A
D000276:Adjuvants, Immunologic; D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D010950:Plasma Cells / Q000187:drug effects / Q000276:immunology*; D051381:Rats; D014001:Tin / Q000276:immunology / Q000633:toxicity*
D000276:Adjuvants, Immunologic; D014001:Tin