title: Rapid HPLC method for the determination of paclitaxel in pharmaceutical forms without separation.
abstract: A HPLC method has been developed for the in-process determination of the paclitaxel from dosage pharmaceutical forms. This method ensures the rapid determination of paclitaxel in the presence of polyoxyl castor oil--the main constituent of paclitaxel's clinical formulation vehicle. The method is simple and rapid and does not require any preliminary treatment of the sample. The method was fully validated.
authors.affiliation: Sindan Pharmaceutical Co., 11 Ion Mihalache Blvd. 78168, Bucharest, Romania. irinel_badea@yahoo.com
authors.forename: Irinel
authors.initials: I
authors.lastname: Badea
authors.forename: Dana
authors.initials: D
authors.lastname: Ciutaru
authors.forename: Lelia
authors.initials: L
authors.lastname: Lazar
authors.forename: Daniela
authors.initials: D
authors.lastname: Nicolescu
authors.forename: Aurel
authors.initials: A
authors.lastname: Tudose
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D017239:Paclitaxel / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis
chemical_list: D004364:Pharmaceutical Preparations; D017239:Paclitaxel