[A rare cause of pulmonary-renal syndrome with autoantibodies: primary antiphospholipid syndrome].
We present a case of primary antiphospholipid syndrome with acute renal failure and alveolar haemorrhage. He was successfully treated with cyclophosphamide, corticosteroids and plasma exchange. Patients with antiphospholipid syndrome may develop a broad spectrum of pulmonary disease. Pulmonary thromboembolism and pulmonary hypertension are the most common complications, but alveolar haemorrhage have also been reported. Other causes need to be excluded. Despite favourable outcome of many patients with association of plasma exchange, immunosuppressive drugs and anticoagulant therapy, definite conclusions about the best therapeutic regimen could not be draw.
Berezne
A
A
Service de néphrologie et transplantation rénale, Hôpital Saint-Louis, Paris.
Karras
A
A
Martinez
F
F
Droz
D
D
Clauvel
J P
JP
Legendre
C
C
D058186:Acute Kidney Injury / Q000209:etiology* / Q000628:therapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000628:therapy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006470:Hemorrhage / Q000139:chemically induced / Q000209:etiology*; D006493:Heparin / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D020767:Intracranial Thrombosis / Q000188:drug therapy / Q000209:etiology; D008171:Lung Diseases / Q000139:chemically induced / Q000209:etiology* / Q000628:therapy; D008297:Male; D010951:Plasma Exchange; D012008:Recurrence; D006435:Renal Dialysis; D012121:Respiration, Artificial; D013577:Syndrome
D000305:Adrenal Cortex Hormones; D017153:Antibodies, Anticardiolipin; D000925:Anticoagulants; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D006493:Heparin