Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.
Adult bone-marrow-derived mesenchymal stem cells are immunosuppressive and prolong the rejection of mismatched skin grafts in animals. We transplanted haploidentical mesenchymal stem cells in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver. Clinical response was striking. The patient is now well after 1 year. We postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo.
Le Blanc
Katarina
K
Division of Clinical Immunology and Centre for Allogeneic Stem Cell Transplantation, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden. Katarina.Leblanc@medhs.ki.se
Rasmusson
Ida
I
Sundberg
Berit
B
Götherström
Cecilia
C
Hassan
Moustapha
M
Uzunel
Mehmet
M
Ringdén
Olle
O
D000208:Acute Disease; D000328:Adult; D002648:Child; D041321:Chromosomes, Human, X; D041322:Chromosomes, Human, Y; D005260:Female; D006086:Graft vs Host Disease / Q000628:therapy*; D006238:Haploidy; D006801:Humans; D007165:Immunosuppression Therapy; D017404:In Situ Hybridization, Fluorescence; D007413:Intestinal Mucosa / Q000648:ultrastructure; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology; D018183:Transplantation Chimera; D014184:Transplantation, Homologous