Selective functionalization in positions 2 and 3 of indole via an iodine-copper exchange reaction.
Two selectively successive I/Cu exchange reactions performed with (Nphyl)CuLi allow the functionalization of indoles in positions 2 and 3. The 2,3-diketones prepared by this method can readily be converted to tricyclic heterocycles by standard methods.
Yang
Xiaoyin
X
Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, München, Germany.
Althammer
Andreas
A
Knochel
Paul
P