title: Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population.
abstract: BACKGROUND
  The mutant allele of mitochondrial aldehyde dehydrogenase (ALDH2(*)2) was found to be associated with Alzheimer's disease (AD) in a Japanese sample, interacting with the apolipoprotein E epsilon 4 allele (Apo E4).
  
  
  OBJECTIVE
  In a community Korean population we sought to investigate associations between ALDH2 genotypes and the following outcomes: cognitive impairment, previous cognitive decline, dementia and AD.
  
  
  METHODS
  Six hundred ninety community residents aged 65 or over were assessed for demographic characteristics, drinking behaviour, cognitive function, clinical diagnoses of dementia and AD, physical health status, and genotype (ALDH2 and Apo E).
  
  
  RESULTS
  There were no significant associations between the ALDH2(*)2 and any cognitive outcome, before or after adjustment for alcohol-related characteristics. These findings were consistent both in the non-drinkers and drinkers. Interaction between ALDH2 and Apo E was only found for one outcome (previous cognitive decline) at borderline levels of significance (P=0.058).
  
  
  CONCLUSIONS
  Overall, these findings in a community population did not support a substantial role for ALDH2 genotype in the aetiology of dementia.
authors.affiliation: Department of Psychiatry, College of Medicine, Chosun University, Kwangju, South Korea.
authors.forename: Jae-Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Robert
authors.initials: R
authors.lastname: Stewart
authors.forename: Il-Seon
authors.initials: IS
authors.lastname: Shin
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Jung
authors.forename: Jin-Sang
authors.initials: JS
authors.lastname: Yoon
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000235:genetics / Q000378:metabolism; D000428:Alcohol Drinking / Q000639:trends; D000437:Alcoholism / Q000201:enzymology / Q000235:genetics; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000544:Alzheimer Disease / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D001921:Brain / Q000201:enzymology* / Q000503:physiopathology; D003072:Cognition Disorders / Q000201:enzymology / Q000235:genetics; D004252:DNA Mutational Analysis; D018450:Disease Progression; D000431:Ethanol / Q000009:adverse effects / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D000431:Ethanol; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000079:Acetaldehyde