[Significance of individual resistance to hypoxia for the correction of the brain trauma sequelae].
In rats, the individual sensitivity to hypoxia plays an prominent role for recovery of animals after mechanic brain injury. Enthomerzol (25 mg/kg intraperitoneally) for three days after brain injury decreased behavioral disorders in rats with different resistance to acute hypoxia, recovered structure of individual behavior, prevented metabolic disorders in brain. Therefore, antihypoxant ethomerzol is effective as a drug against hypoxia due to brain injury.
Zarubina
I V
IV
Russian Military Medical Academy, 194175, St. Petersburg, Lebedeva Street, 6, Russia.
Shabanov
P D
PD
D000208:Acute Disease; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D001930:Brain Injuries / Q000150:complications* / Q000401:mortality; D004198:Disease Susceptibility; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism / Q000517:prevention & control; D008297:Male; D018696:Neuroprotective Agents; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001562:Benzimidazoles; D018696:Neuroprotective Agents; C070941:ethomersol; D010889:Piracetam