Structure-activity relationship of coordinated catecholamine in the [Ru(III)(NH3)4(catecholamine)]+ complex.
The redox chemistry and pharmacological studies of the novel blue ruthenium(III)-catecholamine complexes were investigated in aqueous medium and compared to the free catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ can be oxidized or reduced reversibly in one electron redox couples in aqueous solution. This is in contrast to the free catecholamines, which has a complicated electrochemical behavior due to coupled protonation process. The introduction of the ruthenium group reduces the intrinsic efficacy of the studied catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ complex aqueous medium is more stable than the free catecholamines ligand in the same conditions.
de Lima
Renata Galvão
RG
Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto-USP, Av. dos Bandeirantes, 3900, 14040-901 Ribeirão Preto, São Paulo, Brazil.
Marchesi
Mario Sérgio Pereira
MS
de Godoy
Márcio Augusto Fressatto
MA
Cassano
Adriano Oliano
AO
de Oliveira
Ana Maria
AM
da Silva
Roberto Santana
RS
D000818:Animals; D002395:Catecholamines / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D009942:Organometallic Compounds; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002395:Catecholamines; D009942:Organometallic Compounds; C486938:Ru(III)(NH3)4(catecholamine); D017975:Ruthenium Compounds