[Adjustive effect of yi qi tong lin chongji on the three growth factors in rats prostatic tissues].
OBJECTIVE
To study the mechanisim of Yi Qi Tong Lin Chingji in treating benign prostatic hyperplasia.


METHODS
The expressions of VEGF, bFGF and TGF beta 1 in prostatic hyperplasia model rats were examined by immunohistochemistry. 8 rats were in contrastive group, 24 influenced by Yi Qi Tong Ling Chingji and Prostacar.


RESULTS
The expressions of VEGF and bFGF were significantly difference, but the expression of TGF beta 1 was not significant. (P < 0.01). The expression of VEGF and bFGF were significant in contrastive group to the high-dose of Yi Qi Tong Ling Chingji and Prostacar group (P < 0.05) but were not significant to the low-dose of Yi Qi Tong Ling Chingji group. There was no significant difference between high-dose of Yi Qi Tong Ling Chingji and Prostacar group and three growth factors.


CONCLUSIONS
Yi Qi Tong Ling Chingji inhibit the expression of VEGF and bFGF in BPH so as to decrease the volume of prostate.
Mi
Zheng-guo
ZG
First Hospital, Shanxi Medical University, Taiyuan 030001, Shanxi, China.
Liu
Su-xiang
SX
Cao
Yong-qing
YQ
Yang
Xiao-feng
XF
D031841:Aconitum / Q000737:chemistry; D000818:Animals; D032904:Cinnamomum aromaticum / Q000737:chemistry; D004054:Diethylstilbestrol; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D032267:Rehmannia / Q000737:chemistry; D043343:Testosterone Propionate; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D004054:Diethylstilbestrol; D043343:Testosterone Propionate