[Screening for apoptosis inducers].
We carried out a screening for drugs that can induce apoptosis in human monocytic leukemia U937 cells. In the screening, we found that 8-nitrocaffeine induces cell death distinct from typical apoptosis. Morphological and biochemical analysis revealed that reactive oxygen species mediates the 8-nitrocaffeine-induced necrotic cell death.
Naito
Mikihiko
M
Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
D017209:Apoptosis / Q000187:drug effects*; D002110:Caffeine / Q000031:analogs & derivatives / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020298:U937 Cells / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure
C485124:8-nitrocaffeine; D017382:Reactive Oxygen Species; D002110:Caffeine; D005047:Etoposide