title: Reduce your pelvis in 10000 years or less.
abstract: While the avid dieter obsesses about reduction of different body parts, permanent reduction of many structures seems to be achieved relatively effortlessly (though much more slowly) throughout evolution. In a recent article in Nature, Shapiro et al. examine one such example, the genetic basis of pelvic reduction in the threespine stickleback fish (2004). They conclude that a regulatory mutation in the Pitx1 gene is responsible for the pelvic reduction.
authors.affiliation: Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
authors.forename: Meredith E
authors.initials: ME
authors.lastname: Protas
authors.forename: Clifford J
authors.initials: CJ
authors.lastname: Tabin
mesh_terms: D000818:Animals; D005075:Biological Evolution; D019521:Body Patterning / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics; D023421:Models, Animal; D009154:Mutation / Q000235:genetics; D051761:Paired Box Transcription Factors; D010388:Pelvis / Q000033:anatomy & histology / Q000254:growth & development / Q000502:physiology*; D010641:Phenotype; D023701:Smegmamorpha / Q000235:genetics* / Q000254:growth & development; D013045:Species Specificity; D014157:Transcription Factors / Q000235:genetics
chemical_list: D018398:Homeodomain Proteins; D051761:Paired Box Transcription Factors; D014157:Transcription Factors; C101485:homeobox protein PITX1