title: Rhodium-catalyzed direct C-H addition of 4,4-dimethyl-2-oxazoline to alkenes.
abstract: A new method for the preparation of 2-substituted oxazolines by rhodium-catalyzed coupling of alkenes with 4,4-dimethyl-2-oxazoline is reported. The oxazoline products are obtained in good yield with excellent selectivity for the linear product. A variety of alkene substitution patterns and functional groups are tolerated. This procedure represents an attractive alternative to hydroesterification because it does not involve the manipulation of CO gas.
authors.affiliation: Department of Chemistry, University of California Berkeley, California 94720, USA.
authors.forename: Sean H
authors.initials: SH
authors.lastname: Wiedemann
authors.forename: Robert G
authors.initials: RG
authors.lastname: Bergman
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ellman
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: C494539:4,4-dimethyl-2-oxazoline; D000475:Alkenes; D010080:Oxazoles; D012238:Rhodium