Dopamine and cognitive function.
OBJECTIVE
Although the cognitive deficits of idiopathic Parkinson's disease are now relatively well known, their neuropsychological and neurobiological basis are still discussed.


RESULTS
As well as recent findings on cognitive changes and their underlying mechanisms, we will review new approaches concerning the effects of levo-dihydroxyphenylalanine, those of deep-brain stimulation and recent developments on personality disorders.


CONCLUSIONS
Future research directions concern the relative influence of the striatofrontal loops in cognition and personality, and the respective contribution of subcortical and cortical lesions or dysfunctions, both in dementia and in specific cognitive and personality changes.
Pillon
Bernard
B
INSERM EMI 007 and Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France. bernard.pillon@psl.ap-hop-paris.fr
Czernecki
Virginie
V
Dubois
Bruno
B
D001923:Brain Chemistry / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D003704:Dementia / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology*
D004298:Dopamine