title: Unusual transcription regulation of the niaD gene under anaerobic conditions supporting fungal ammonia fermentation.
abstract: The niaD gene of the fungus Aspergillus nidulans encodes an assimilatory nitrate reductase and exogenous ammonium represses its expression. Under anoxic conditions, however, A. nidulans expressed niaD even in the presence of ammonium and used the gene product for dissimilatory nitrate reduction (ammonia fermentation). This transcription regulation mechanism under anaerobiosis is critical for the fungus to ferment ammonium.
authors.affiliation: Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Takasaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shoun
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hoshino
authors.forename: Naoki
authors.initials: N
authors.lastname: Takaya
mesh_terms: D000641:Ammonia / Q000378:metabolism*; D000693:Anaerobiosis / Q000187:drug effects; D001233:Aspergillus nidulans / Q000235:genetics* / Q000378:metabolism*; D002457:Cell Extracts; D005285:Fermentation / Q000187:drug effects; D005656:Fungal Proteins / Q000235:genetics; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects; D005800:Genes, Fungal / Q000235:genetics*; D009566:Nitrates / Q000494:pharmacology; D009572:Nitrite Reductases / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics*; D001617:beta-Glucosidase / Q000378:metabolism
chemical_list: D002457:Cell Extracts; D005656:Fungal Proteins; D009566:Nitrates; D000641:Ammonia; D009572:Nitrite Reductases; D001617:beta-Glucosidase; D010100:Oxygen