title: Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats.
abstract: In the present study an attempt has been made to evaluate the presence of hypoglycemic activity in the alcoholic extract of Aloe vera gel. Effects of oral administration of A. vera extract at a concentration of 200 and 300 mg/kg of body weight on (a) normal fasted rats, (b) oral glucose-loaded rats, and (c) streptozotocin-induced diabetic rats have been studied. A. vera extract maintain the glucose homeostasis by controlling the carbohydrate metabolizing enzymes.
authors.affiliation: Department of Biochemistry & Molecular Biology, University of Madras, Chennai, Tamil Nadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Rajasekaran
authors.forename: K
authors.initials: K
authors.lastname: Sivagnanam
authors.forename: K
authors.initials: K
authors.lastname: Ravi
authors.forename: S
authors.initials: S
authors.lastname: Subramanian
mesh_terms: D000284:Administration, Oral; D000504:Aloe / Q000737:chemistry; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005782:Gels; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D001786:Blood Glucose; D005782:Gels; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin