title: Incidence of group C human rotavirus in central Australia and sequence variation of the VP7 and VP4 genes.
abstract: Human group C rotavirus was identified in central Australia in each of eight years over a 16-year period between 1982 and 1997. Cases occurred either sporadically but over a relatively short period of time or as clustered outbreaks. These are the only reports of human group C rotavirus in Australia other than that of a single case reported approximately 1,800 km away in 1982. The electrophoretic genome profiles of isolates were identical for all those identified within the same year but different between those identified in different years. The VP7 genes of four isolates identified in four different years over a 7-year period between 1987 and 1993, and the VP4 genes of two of these isolates showed relatively little variation in genome and deduced amino acid sequence upon comparison of the equivalent genes between isolates. The sequences were also very similar to those from the corresponding genes from most of the human group C rotavirus isolates from other countries. This continues the observation of a high degree of gene sequence conservation among human group C rotaviruses worldwide.
authors.affiliation: Department of Microbiology, La Trobe University, Victoria 3086, Australia. r.schnagel@latrobe.edu.au
authors.forename: Roger D
authors.initials: RD
authors.lastname: Schnagl
authors.forename: Karen
authors.initials: K
authors.lastname: Boniface
authors.forename: Pauline
authors.initials: P
authors.lastname: Cardwell
authors.forename: Damien
authors.initials: D
authors.lastname: McCarthy
authors.forename: Caroline
authors.initials: C
authors.lastname: Ondracek
authors.forename: Barbara
authors.initials: B
authors.lastname: Coulson
authors.forename: John
authors.initials: J
authors.lastname: Erlich
authors.forename: Fran
authors.initials: F
authors.lastname: Morey
mesh_terms: D000595:Amino Acid Sequence; D000956:Antigens, Viral / Q000235:genetics*; D036022:Capsid Proteins / Q000235:genetics*; D002675:Child, Preschool; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology; D005814:Genes, Viral; D014644:Genetic Variation; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D008969:Molecular Sequence Data; D015876:Northern Territory / Q000453:epidemiology; D010802:Phylogeny; D012401:Rotavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology*; D017386:Sequence Homology, Amino Acid; D013997:Time Factors
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus