title: Screening for late effects in survivors of childhood cancer: growth hormone deficiency from a pediatric oncologist's point of view.
abstract: At the Emma Kinderziekenhuis/Academic Medical Center in Amsterdam, survivors of childhood cancer are screened annually or biennially for the occurrence of late treatment effects. The screening procedures are based on previously used treatment modalities. The data gathered at the outpatient clinic are registered in the database PLEKsys. Evaluation of the data concerning over 1000 cancer survivors screened since the start of the clinic once more illustrated the relation between cranial irradiation and the development of central endocrine abnormalities. Surprisingly, at least a proportion of the growth hormone (GH)-deficient cancer survivors were registered as not being on a replacement therapy regimen. The reasons for survivors not to be on replacement therapy are currently being evaluated. The late-effects outpatient clinic and the PLEKsys database provide a platform for additional research in fields including endocrinology, which should be aimed at improving the care for and the health status of the survivors of childhood cancer.
authors.affiliation: Polikliniek Late Effecten Kindertumoren (PLEK) and Late Effects Study Group Emma Kinderziekenhuis/Academic Medical Center, Amsterdam, The Netherlands. c.vandenbos@amc.uva.nl
authors.forename: C
authors.initials: C
authors.lastname: van den Bos
authors.forename: R C
authors.initials: RC
authors.lastname: Heinen
authors.forename: M
authors.initials: M
authors.lastname: Sukel
authors.forename: H J H
authors.initials: HJ
authors.lastname: van der Pal
authors.forename: M M
authors.initials: MM
authors.lastname: Geenen
mesh_terms: D002648:Child; D003266:Continuity of Patient Care; D004700:Endocrine System Diseases / Q000188:drug therapy / Q000209:etiology*; D005500:Follow-Up Studies; D020249:Hormone Replacement Therapy; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D016347:Medical Records Systems, Computerized; D009369:Neoplasms / Q000628:therapy*; D017741:Survivors / Q000706:statistics & numerical data*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone