title: Bcl-6 gene mutations in primary cutaneous B-cell lymphomas.
abstract: We analyzed mutations in the 5' non-coding region of the BCL-6 gene in 46 cases of primary cutaneous B-cell lymphomas (PCBCL), using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) method. The results indicate that PCBCL display a low frequency of mutations and support a marginal zone B-cell origin for most of these neoplasms.
authors.forename: Umberto
authors.initials: U
authors.lastname: Gianelli
authors.forename: Amilcare
authors.initials: A
authors.lastname: Cerri
authors.forename: Barbara
authors.initials: B
authors.lastname: Cassani
authors.forename: Laura
authors.initials: L
authors.lastname: Moneghini
authors.forename: Paola Rafaniello
authors.initials: PR
authors.lastname: Raviele
authors.forename: Emilio
authors.initials: E
authors.lastname: Berti
authors.forename: Silvano
authors.initials: S
authors.lastname: Bosari
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D051560:Proto-Oncogene Proteins c-bcl-6