title: Geniposide, an anti-angiogenic compound from the fruits of Gardenia jasminoides.
abstract: The EtOH extract of gardenia (Gardenia jasminoides Ellis) fruits was previously found to possess potent anti-angiogenic activity in the chick embryo chorioallantoic membrane (CAM) assay. Bioassay-guided fractionation and purification of the EtOH extract yielded an active anti-angiogenic compound, which was determined to be an iridoid glucoside, geniposide, by spectral analyses. Geniposide showed anti-angiogenic activity in a dose-dependent manner. It also exhibited an inhibitory effect in the range of 25-100 microM on the growth of the transformed NIH3T3 cell line.
authors.affiliation: College of Pharmacy, Sookmyung Women's University, Seoul, Korea.
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Koo
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Kuk-Hyun
authors.initials: KH
authors.lastname: Shin
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Kim
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Lim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Park
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002645:Chickens; D020256:Choroidal Neovascularization / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D032062:Gardenia; D039823:Iridoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011714:Pyrans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D020533:Angiogenesis Inhibitors; D039823:Iridoids; D010936:Plant Extracts; D011714:Pyrans; C007835:geniposide