title: MTHFR C677T polymorphism and its relation to ischemic stroke in the Black Sea Turkish population.
abstract: The MTHFR C677T mutation has been shown to be associated with venous thrombosis. The role of this mutation in ischemic stroke is unclear. We investigated whether the MTHFR mutation is a risk factor for patients with ischemic stroke in the Black Sea Turkish population or not. We analyzed 30 patients (19 male, 11 female) [median age: 50 years (range: 28-78)] with ischemic stroke who had no known predisposition factors for stroke and 242 (182 male, 60 female) healthy controls [median age: 42 years (range: 18-65)]. Detection of the MTHFR C677T mutation was performed by using commercially available allele-specific PCR-ELISA kits. Prevalence of the MTHFR C677T genotype was 49.1% (CT, 45.8%; TT, 3.3%) in controls and 50% (CT, 43.3%; TT, 6.6%) in patients [OR: 1.03, 95% CI (0.45-2.35]). The prevalence of homozygous gene mutation for MTHFR was higher among patients with stroke than control subjects, but this difference was not statistically significant. The MTHFR gene mutation is not a risk factor for ischemic stroke formation in patients from the Black Sea region in Turkey.
authors.affiliation: Department of Medical Biology & Genetics, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. fahriu@yahoo.com
authors.forename: Fahri
authors.initials: F
authors.lastname: Uçar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sönmez
authors.forename: Ercüment
authors.initials: E
authors.lastname: Ovali
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozmenoglu
authors.forename: S Sami
authors.initials: SS
authors.lastname: Karti
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Alper
authors.initials: A
authors.lastname: Pakdemir
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D009792:Oceans and Seas; D011110:Polymorphism, Genetic; D015995:Prevalence; D020521:Stroke / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)