title: Angiotensin-converting enzyme gene polymorphism in coronary artery disease in north India.
abstract: BACKGROUND
  The aim of this study was to investigate the role of angiotensin-converting enzyme gene polymorphism in patients with coronary artery disease in north India.
  
  
  RESULTS
  One hundred forty-six patients with angiographically proven atherosclerotic coronary artery disease, and 146 age- and sex-matched control subjects (treadmill-negative) were included in the study. Genomic DNA was extracted and analyzed for angiotensin-converting enzyme insertion/deletion polymorphism. Two independent investigators scored the genotypes.
  
  
  CONCLUSIONS
  When we compared the genotypes of patients with coronary artery disease with those of normal controls, it was seen that all three genotypes, i.e. DD, ID and II, were not statistically different among patients and controls. Further, we categorized the patient and control groups into 2 subgroups, i.e. below and above 50 years of age. Interestingly, it was observed that the DD genotype was significantly higher in patients in the higher age group (i.e. above 50 years of age). However, this needs further validation by studying patients with coronary artery disease from other parts of India.
authors.affiliation: Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. suraksha@sgpgi.ac.in
authors.forename: Suraksha
authors.initials: S
authors.lastname: Agrawal
authors.forename: Vivek Pratap
authors.initials: VP
authors.lastname: Singh
authors.forename: Satyendra
authors.initials: S
authors.lastname: Tewari
authors.forename: Nakul
authors.initials: N
authors.lastname: Sinha
authors.forename: V
authors.initials: V
authors.lastname: Ramesh
authors.forename: Sarita
authors.initials: S
authors.lastname: Agarwal
authors.forename: Ashley
authors.initials: A
authors.lastname: Gilmour
authors.forename: Sarabjit
authors.initials: S
authors.lastname: Mastana
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000201:enzymology* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A