Mortality associated with pheochromocytoma in a large Swedish cohort.
BACKGROUND
The aim of the present study was to report the risk of death in a national cohort of patients with aPC (adrenal PC) and their risk of developing a second tumour.


METHODS
Using the National Cancer Registry, 481 patients (222 men and 259 women) with aPC in Sweden (1958-1997) were identified. Autopsy-based diagnoses were excluded. As control group the entire Swedish population was used and the risk of death in patients after diagnosis of aPC was compared with the normal risk taking age, sex and calendar year into account. The risk for a second tumour disease after diagnosis of aPC was also calculated.


RESULTS
Patients with aPC had an increased tumour-related mortality after diagnosis of aPC. For both men and women this mortality was four times higher than for controls. Liver/biliary tract and CNS tumours in men; and malignant melanoma and uterine cervical cancer in women were significantly over-represented in the cohort of patients with aPC.


CONCLUSIONS
Patients with aPC run an increased risk of developing additional cancers. Surveillance strategies may thus be necessary for these patients.
Khorram-Manesh
A
A
Departments of Surgery and Pathology at Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Göteborg, Sweden. amir.khorram-manesh@surgery.gu.se
Ahlman
H
H
Nilsson
O
O
Odén
A
A
Jansson
S
S
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000401:mortality*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001661:Biliary Tract Neoplasms / Q000453:epidemiology / Q000556:secondary; D001943:Breast Neoplasms / Q000453:epidemiology / Q000556:secondary; D016543:Central Nervous System Neoplasms / Q000453:epidemiology / Q000556:secondary; D002584:Cervix Uteri / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000556:secondary; D008875:Middle Aged; D010673:Pheochromocytoma / Q000401:mortality*; D012307:Risk Factors; D013223:Statistics as Topic; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000556:secondary