title: Anti-inflammatory and analgesic activity of Peperomia pellucida (L.) HBK (Piperaceae).
abstract: An aqueous extract of the aerial part of Peperomia pellucida (L.) HBK (Piperaceae) was tested for anti-inflammatory (paw edema induced by carrageenin and arachidonic acid) and analgesic activity (abdominal writhes and hot plate) in rats and mice, respectively. Oral administration of 200 and 400 mg/kg of the aqueous extract exhibited an anti-inflammatory activity in the carrageenin test, which was based on interference with prostaglandin synthesis, as confirmed by the arachidonic acid test. In the abdominal writhing test induced by acetic acid, 400 mg/kg of the plant extract had the highest analgesic activity, whereas in the hot-plate test the best dose was 100 mg/kg. The LD(50) showed that Peperomia pellucida (5000 mg/kg) presented low toxicity.
authors.affiliation: Laboratório de Farmacologia, Departamento de Fisiologia/CCBS, Universidade Federal de Sergipe, Campus Universitário, São Cristóvão, SE CEP 49100-000, Brazil.
authors.forename: Maria
authors.initials: M
authors.lastname: de Fátima Arrigoni-Blank
authors.forename: Elena G
authors.initials: EG
authors.lastname: Dmitrieva
authors.forename: Elaine Maria
authors.initials: EM
authors.lastname: Franzotti
authors.forename: Angelo Roberto
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Márcio Roberto
authors.initials: MR
authors.lastname: Andrade
authors.forename: Murilo
authors.initials: M
authors.lastname: Marchioro
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016718:Arachidonic Acid; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006358:Hot Temperature; D008297:Male; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D036941:Peperomia; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D016718:Arachidonic Acid; D002351:Carrageenan; D019342:Acetic Acid