title: Biomimetic model of skeletal muscle isometric contraction: II. A phenomenological model of the skeletal muscle excitation-contraction coupling process.
abstract: This paper describes a new macroscopic, phenomenological model of the skeletal muscle excitation-contraction coupling process, as represented by four principal and consecutive compartments (biophysical, biochemical, and biomechanical phases) characteristic of isometric excitation-contraction coupling in mammalian skeletal muscle, and coupled by a system of simultaneous, first-order linear ordinary differential equations. The model is based upon biological compartmental transport kinetics and irreversible thermodynamic energy transformation, and represents a distinct improvement over other biomimetic models. The model was derived using physiological parameter data published in the literature, and validated using MATLAB R12.
authors.affiliation: Department of Biomedical, Industrial, and Human Factors Engineering, 207, Russ Engineering Center, Wright State University, Dayton, OH 45435-0001, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: Neidhard-Doll
authors.forename: C A
authors.initials: CA
authors.lastname: Phillips
authors.forename: D W
authors.initials: DW
authors.lastname: Repperger
authors.forename: D B
authors.initials: DB
authors.lastname: Reynolds
mesh_terms: D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology*; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000502:physiology*
chemical_list: D002118:Calcium