title: Modal gating of NMDA receptors.
abstract: The decay time course of excitatory postsynaptic currents generated by slow glutamatergic synapses is determined by the single-channel kinetics of postsynaptic NMDA receptor channels. In a recent study, examination of these single-channel kinetics has revealed that NMDA receptors can enter into modal gating. Linear free-energy analysis suggests that the various modes arise from a common reaction mechanism, providing further insight into the gating underlying decay of the slow synaptic response.
authors.affiliation: Department of Physiology and Biophysics, University of Miami School of Medicine, PO Box 016430, Miami, FL 33101-6430, USA. kmagleby@miami.edu
authors.forename: Karl L
authors.initials: KL
authors.lastname: Magleby
mesh_terms: D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology*; D007700:Kinetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate