title: Paraneoplastic "stiff person syndrome" with metastatic adenocarcinoma and anti-Ri antibodies.
abstract: A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma of the lung with positive anti-Ri antibodies. Her clinical condition improved with diazepam, baclofen, tizanidine, and palliative chemotherapy. Screening for an underlying malignancy and anti-Ri antibodies should be considered in patients with SPS when clinical presentation is atypical.
authors.affiliation: University Department of Clinical Neurosciences, Royal Free and University College, Medical School, London, UK. d.mccabe@ion.ucl.ac.uk
authors.forename: D J H
authors.initials: DJ
authors.lastname: McCabe
authors.forename: N C
authors.initials: NC
authors.lastname: Turner
authors.forename: D
authors.initials: D
authors.lastname: Chao
authors.forename: A
authors.initials: A
authors.lastname: Leff
authors.forename: N A
authors.initials: NA
authors.lastname: Gregson
authors.forename: H J
authors.initials: HJ
authors.lastname: Womersley
authors.forename: I
authors.initials: I
authors.lastname: Mak
authors.forename: G D
authors.initials: GD
authors.lastname: Perkin
authors.forename: A H V
authors.initials: AH
authors.lastname: Schapira
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000276:immunology* / Q000556:secondary; D000328:Adult; D002272:Carcinoembryonic Antigen / Q000097:blood; D003680:Deglutition Disorders / Q000209:etiology; D004401:Dysarthria / Q000209:etiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000276:immunology*; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D009474:Neurons / Q000276:immunology; D010166:Palliative Care; D020361:Paraneoplastic Syndromes, Nervous System / Q000175:diagnosis / Q000276:immunology*; D011877:Radionuclide Imaging; D013116:Spinal Cord / Q000276:immunology; D016750:Stiff-Person Syndrome / Q000175:diagnosis / Q000276:immunology*; D034941:Upper Extremity / Q000503:physiopathology
chemical_list: D002272:Carcinoembryonic Antigen; D019788:Fluorodeoxyglucose F18