Aqueous liquid scintillation counting with fluor-containing nanosuspensions.
A microemulsion comprised of water, Brij 78, pentanol and styrene into which PPO and bis-MSB had been dissolved was prepared. Polymerization of the styrene resulted in a suspension of fluor-containing polystyrene nanoparticles (<100 nm). After a concentration step, the aqueous nanosuspension was able to detect (14)C with counting efficiencies over 50% of those of a commercially available scintillation cocktail. Monte Carlo calculations demonstrated that the size and concentration of the nanoparticles were appropriate for optimum detection efficiency.
Weekley
James C
JC
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA.
Wuenschel
Sara
S
Rosenstiel
Paul E
PE
Mumper
Russell J
RJ
Jay
Michael
M
D002250:Carbon Radioisotopes / Q000032:analysis*; D004655:Emulsions; D007202:Indicators and Reagents; D011868:Radioisotopes / Q000032:analysis*; D012588:Scintillation Counting / Q000379:methods*; D013501:Surface-Active Agents; D014867:Water / Q000032:analysis*
D002250:Carbon Radioisotopes; D004655:Emulsions; D007202:Indicators and Reagents; D011868:Radioisotopes; D013501:Surface-Active Agents; D014867:Water