Deleterious effects of an environmental noise on sleep and contribution of its physical components in a rat model.
Sleep disturbances induced by environmental noise (EN) exposure are now well admitted. However, many contradictory conclusions and discrepancies have been reported, resulting from uncontrolled human factors or the use of artificial noises (pure tone). Thus, the development of an animal model appears to be a useful strategy for determining whether EN is deleterious to sleep. The aims of this study were: (i) to confirm the effects of noise on sleep in a rat model; and (ii) to determine the most deleterious physical component of noise regarding sleep structure. For this purpose, rats were exposed during 24 h either to EN or to artificial broad-band noises [either continuous broad-band noise (CBBN) or intermittent broad-band noise (IBBN)]. All the noises decrease both slow wave sleep (SWS) and paradoxical sleep (PS) amounts during the first hours of exposure. However, CBBN acts indirectly on PS through a reduction of SWS bout duration, whereas IBBN and EN disturb directly and more strongly both SWS and PS. Finally, EN fragments SWS and decreases PS amount during the dark period, whereas IBBN only fragments PS. These results demonstrate the validity and suitability of a rodent model for studying the effects of noise on sleep and definitively show that sleep is disturbed by EN exposure. Two physical factors seem to be implicated: the intermittency and the frequency spectrum of the noise events, which both induce long-lasting sleep disturbances. An additive effect of frequency spectrum to intermittency tends to abolish all possible adaptations to EN exposure. Since sleep is involved in cognitive processes, such disturbances could lead to cognitive deficits.
Rabat
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INSERM Unité 588, Physiopathologie du Comportement, Institut François Magendie, Université Bordeaux II, 1 rue Camille St Saëns, Bordeaux Cedex 33077, France. arnaud.rabat@bordeaux.inserm.fr
Bouyer
J J
JJ
Aran
J M
JM
Courtiere
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Mayo
W
W
Le Moal
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D000818:Animals; D002940:Circadian Rhythm; D004569:Electroencephalography / Q000379:methods; D004777:Environment; D008297:Male; D023421:Models, Animal; D009622:Noise / Q000009:adverse effects*; D017286:Polysomnography / Q000379:methods; D051381:Rats; D020318:Rats, Long-Evans; D012894:Sleep Stages / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*