IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia.
Previous studies have established that impaired glucose tolerance (IGT) patients with fasting hyperglycemia (IGT/FH: fasting plasma glucose (FPG) level 6.1-7.0 mmol/l and 2 h PG level of 7.8-11.1 mmol/l) exhibit higher insulin resistance than those with isolated IGT (FPG level <6.1 mmol/l and 2 h PG level of 7.8-11.1 mmol/l), but the association with microalbuminuria has not been determined. Here, we evaluate the prevalence of microalbuminuria in non-diabetic Japanese males 20-70 years of age. The subjects were classified into four groups based on the results of OGTT: normal glucose tolerance (NGT: n=71), impaired fasting glucose (IFG: n=24), isolated IGT (n=36), and IGT/FH (n=23). A urinary albumin-to-creatinine ratio (ACR) from 30 to 300 microg/mg creatinine was counted as microalbuminuria. The prevalence of microalbuminuria was higher in subjects with IGT/FH than in subjects with isolated IGT (26% versus 14%). Logistic regression analysis showed microalbuminuria to be more significantly associated with IGT/FH (OR=3.82, 95% CI 1.09-13.36) than with isolated IGT (OR=1.75, 95% CI 0.50-6.17). While insulin resistance (HOMA-IR) in isolated IGT was not significantly different from that in NGT, insulin resistance in IGT/FH was significantly higher (P<0.01). Regression analysis of ACR in IGT showed a significant correlation with insulin resistance (P=0.012). Accordingly, microalbuminuria is more strongly associated with IGT/FH than with isolated IGT, most likely due to the higher insulin resistance.
Suzuki
Haruhiko
H
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
Fukushima
Mitsuo
M
Usami
Masaru
M
Ikeda
Masaki
M
Taniguchi
Ataru
A
Nakai
Yoshikatsu
Y
Matsuura
Toshifumi
T
Yasuda
Koichiro
K
Hosokawa
Masaya
M
Seino
Yutaka
Y
Yamada
Yuichiro
Y
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000175:diagnosis / Q000652:urine; D044466:Asian People / Q000208:ethnology; D001786:Blood Glucose / Q000737:chemistry; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood*; D018149:Glucose Intolerance / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005951:Glucose Tolerance Test / Q000379:methods; D006442:Glycated Hemoglobin / Q000737:chemistry; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000150:complications* / Q000175:diagnosis; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D008076:Cholesterol, HDL; D003404:Creatinine; D006442:Glycated Hemoglobin; D014280:Triglycerides