title: p53 designer genes for the modern mouse.
abstract: Major efforts are underway to develop molecular strategies that target the p53 pathway for the treatment of cancer. Mouse strains with humanized p53 sequences that present the precise human DNA-binding domain as mutation target could be informative models to test p53 rescue drugs, and to explore experimentally the causes of human tumor mutations.
authors.affiliation: Department of Genetic Alterations in Carcinogenesis, German Cancer Research Center, Heidelberg, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Hergenhahn
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Luo
authors.forename: Monica
authors.initials: M
authors.lastname: Hollstein
mesh_terms: D000818:Animals; D016158:Genes, p53 / Q000235:genetics*; D005818:Genetic Engineering; D024861:Genetic Enhancement; D006801:Humans; D051379:Mice