Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.
For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C(15) showed the most significant dual COX/5-LOX inhibitory activity.
Jahng
Yurngdong
Y
College of Pharmacy, Yeungnam University, Kyongsan 712-749, South Korea.
Zhao
Long-Xuan
LX
Moon
Yoon-Soo
YS
Basnet
Arjun
A
Kim
Eun-kyung
EK
Chang
Hyeun Wook
HW
Ju
Hye Kyung
HK
Jeong
Tae Cheon
TC
Lee
Eung-Seok
ES
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000201:enzymology; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D016859:Lipoxygenase Inhibitors