title: Achalasia treatment: improved outcome of laparoscopic myotomy with operative manometry.
abstract: OBJECTIVE
  Operative manometry detects residual esophagogastric junction (EGJ) high pressure, ensuring complete myotomy.
  
  
  METHODS
  Consecutive patients undergoing laparoscopic myotomy.
  
  
  METHODS
  Tertiary care academic medical center.
  
  
  METHODS
  From 1997 to 2003, 139 patients with achalasia underwent laparoscopic myotomy.
  
  
  METHODS
  We assessed myotomy completeness by operative endoscopy and performed operative manometry to measure pressure across the EGJ myotomy. Residual high pressure was isolated and intact muscle divided.
  
  
  METHODS
  Esophageal manometry, quality of life, and dysphagia severity score.
  
  
  RESULTS
  Median lower esophageal sphincter pressure was 27 mm Hg preoperatively; 10 patients had sigmoid esophagus and 57 had previous dilation and/or toxin injection. There were 136 laparoscopic myotomies and 3 conversions to open procedures (2%). Operative endoscopy was performed in all patients. Operative manometry, completed in 132 patients (95%), identified residual EGJ high pressure leading to myotomy revision in 45 patients (31 in the first 70 treated). Small perforations occurred in 19 patients, associated with previous dilation and/or toxin injection in 12 patients. One-month follow-up was available in 136 patients (98%); 126 patients had minimal symptoms (93%), whereas 1 had recurrent EGJ high pressure, 5 esophagitis, 3 sigmoid esophagus, and 1 paraesophageal hernia. In 60 patients with complete 1-year follow-up, quality of life and dysphagia improved (P <.05); mean lower esophageal sphincter pressure decreased to 7.6 mm Hg (P <.05).
  
  
  CONCLUSIONS
  Operative manometry identifies residual EGJ high pressure and reduces the incidence of incomplete myotomy. Laparoscopic myotomy improves quality of life and dysphagia symptoms and may be the treatment of choice in most patients with achalasia.
authors.affiliation: Surgical Service, Veterans Affairs Chicago Health Care System-Lakeside Division, and Department of Surgery, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Chapman
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Joehl
authors.forename: Kenric M
authors.initials: KM
authors.lastname: Murayama
authors.forename: Roger P
authors.initials: RP
authors.lastname: Tatum
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Shi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hirano
authors.forename: Michael P
authors.initials: MP
authors.lastname: Jones
authors.forename: John E
authors.initials: JE
authors.lastname: Pandolfino
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Kahrilas
mesh_terms: D000328:Adult; D003680:Deglutition Disorders / Q000209:etiology; D013505:Digestive System Surgical Procedures; D004931:Esophageal Achalasia / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D010535:Laparoscopy; D007902:Length of Stay; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies