title: Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population.
abstract: Psoriatic arthritis (PsA) has been defined as an inflammatory arthritis associated with psoriasis that may affect as many as 30% of psoriasis patients. Epidemiological study reported strong familial clustering of PsA although the precise etiology of PsA is poorly understood. Recently, a genomewide linkage scan in PsA revealed a LOD score of 2.17 on chromosome 16q and provided strong evidence for a paternal imprinting effect. That region surrounds a psoriasis susceptibility locus including the CARD15 gene which has convincingly been shown to confer susceptibility to Crohn's disease. The existence of a common susceptibility gene for psoriasis/PsA and Crohn disease was recently demonstrated by evidence of association of CARD15 polymorphisms with PsA. To confirm these results in an independent population, we analyzed a data set of 193 Italian PsA patients and 150 controls for CARD15 polymorphisms (R702W, G908R and leu1007finsC) previously demonstrated associated with PsA. Here we report no evidence for association in the examined population for CARD15 polymorphisms, suggesting that the positive association previously reported in a genetically isolated population was the result of a linkage disequilibrium due to a founder effect.
authors.affiliation: Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy. emizago@yahoo.com
authors.forename: Emiliano
authors.initials: E
authors.lastname: Giardina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Novelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Costanzo
authors.forename: Steven
authors.initials: S
authors.lastname: Nisticò
authors.forename: Cristina
authors.initials: C
authors.lastname: Bulli
authors.forename: Cecilia
authors.initials: C
authors.lastname: Sinibaldi
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Sorgi
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
authors.forename: Egisto
authors.initials: E
authors.lastname: Taccari
authors.forename: Paola
authors.initials: P
authors.lastname: Borgiani
mesh_terms: D015535:Arthritis, Psoriatic / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D018703:Founder Effect; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007558:Italy; D015810:Linkage Disequilibrium; D053473:Nod2 Signaling Adaptor Protein; D011110:Polymorphism, Genetic
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein