Towards configurationally stable bisindolylmaleimide cyclophanes: potential tools for investigating protein kinase function.
The effect of macrocycle size and substitution on the configurational stability of some bisindolylmaleimide cyclophanes was determined.
Bartlett
Stephen
S
Department of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK LS2 9JT.
Nelson
Adam
A
D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D064546:Protein Kinase C beta; D019311:Staurosporine / Q000494:pharmacology; D013237:Stereoisomerism
D004791:Enzyme Inhibitors; D007211:Indoles; D008301:Maleimides; D011493:Protein Kinase C; D064546:Protein Kinase C beta; D019311:Staurosporine; C088060:bisindolylmaleimide