Aureolic acids: similar antibiotics with different biosynthetic gene clusters.
In this issue of Chemistry & Biology, Méndez and colleagues describe the sequence and organization of the chromomycin gene cluster. Unexpectedly, the arrangement is starkly different from the mithramycin biosynthetic cluster, despite similarity in the individual genes and the near identical structures of the two antibiotic aureolic acids.
O'Connor
Sarah
S
Massachusetts Institute of Technology, Cambridge 02139, USA.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002865:Chromomycins / Q000096:biosynthesis*; D005798:Genes, Bacterial; D015394:Molecular Structure; D005810:Multigene Family; D008926:Plicamycin / Q000096:biosynthesis* / Q000737:chemistry; D013305:Streptomyces griseus / Q000235:genetics / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D001426:Bacterial Proteins; D002865:Chromomycins; D008926:Plicamycin