Venusol from Gunnera perpensa: structural and activity studies.
From the aqueous extract of the dry rhizomes of Gunnera perpensa the minor components pyrogallol, succinic acid, lactic acid, and the trimethyl ether of ellagic acid glucoside were isolated. The major constituent was identified as Z-venusol, a phenylpropanoid glucoside. Its structure was verified by X-ray diffraction. Tests on isolated uterine smooth muscle from rats showed that the whole extract stimulated a direct contractile response and induced a state of continuous contractility of the uterus once all additives had been removed from the organ bath. By contrast, venusol did not trigger the direct contractile response but induced the state of continuous contractility once the organ bath was flushed.
Khan
Fatima
F
School of Chemical and Physical Sciences (Chemistry), University of Natal, Private Bag X01, Scottsville, 3209, Pietermaritzburg, South Africa.
Peter
Xolani K
XK
Mackenzie
Rod M
RM
Katsoulis
Lynn
L
Gehring
Ronette
R
Munro
Orde Q
OQ
van Heerden
Fanie R
FR
Drewes
Siegfried E
SE
D000818:Animals; D018360:Crystallography, X-Ray; D005260:Female; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D016488:Medicine, African Traditional; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D010120:Oxytocics / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010666:Phenylpropionates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D006027:Glycosides; D010120:Oxytocics; D010666:Phenylpropionates; C421562:venusol