Evidence that human genes of modular proteins have retained significantly more ancestral introns than their fly or worm orthologues.
Comparison of the exon-intron structures of human, fly and worm orthologues of mosaic genes assembled from class 1-1 modules by exon-shuffling has revealed that human genes retained significantly more of the original inter-module introns than their protostome orthologues. It is suggested that the much higher rate of intron loss in the worm- and insect lineages than in the chordate lineage reflects their greater tendency for genome compaction.
Bányai
László
L
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, P.O. Box 7, H-1518 Budapest, Hungary.
Patthy
László
L
D000465:Algorithms; D000818:Animals; D017173:Caenorhabditis elegans; D019070:Cell Lineage; D018076:DNA, Complementary / Q000378:metabolism; D004330:Drosophila; D019143:Evolution, Molecular; D005091:Exons; D006801:Humans; D020407:Internet; D007438:Introns; D008957:Models, Genetic; D017434:Protein Structure, Tertiary; D013045:Species Specificity
D018076:DNA, Complementary