Pancreas preservation with University of Wisconsin and Celsior solutions.
BACKGROUND
Although the use of Celsior has been recently described for heart, lung, liver, and kidney transplantation, no data are available on its use for clinical pancreas preservation.


METHODS
We herein describe the results of 112 pancreas transplants preserved with either University of Wisconsin (UW; (n = 56) or Celsior (n = 56) solution at two Italian transplant centers. The groups were comparable with regard to all donor and recipient characteristics.


RESULTS
Mean cold and warm ischemia times were 10.1 +/- 2.2 hours and 37.2 +/- 8.2 minutes for UW compared to 10.8 +/- 2.4 hours and 38.3 +/- 6.7 minutes for Celsior (P = NS). Delayed endocrine pancreas function was recorded in two UW-preserved grafts (3.6%). Actuarial 1-year patient survival was 94.6% for UW as compared with 100% for Celsior (P = NS). Equivalent graft survival figures were 91.0% for UW as compared with 96.4% for Celsior (P = NS).


CONCLUSIONS
Within the range of cold ischemia times reported in this study, UW and Celsior solutions have similar safety profiles for pancreas transplantation.
Boggi
U
U
Divisione di Chirurgia Generale e Trapianti, Università di Pisa, Pisa, Italy.
Coletti
L
L
Vistoli
F
F
Del Chiaro
M
M
Signori
S
S
Croce
C
C
Bartolo
T Vanadia
TV
Pietrabissa
A
A
Marchetti
P
P
Capocasale
E
E
Dalla Valle
R
R
Mazzoni
M P
MP
Mosca
F
F
D000241:Adenosine; D000328:Adult; D000493:Allopurinol; D001786:Blood Glucose / Q000032:analysis; D004187:Disaccharides; D004573:Electrolytes; D005260:Female; D005971:Glutamates; D005978:Glutathione; D006085:Graft Survival / Q000502:physiology; D006639:Histidine; D006650:Histocompatibility Testing; D006801:Humans; D007328:Insulin; D007511:Ischemia; D007558:Italy; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D016377:Organ Transplantation / Q000502:physiology*; D010179:Pancreas; D016035:Pancreas Transplantation / Q000401:mortality / Q000502:physiology*; D011887:Raffinose; D012189:Retrospective Studies; D016019:Survival Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data
D001786:Blood Glucose; C088453:Celsior; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D008353:Mannitol; D006639:Histidine; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose