title: Sepsis and elevated liver enzymes in a patient with inflammatory bowel disease: think of portal vein thrombosis.
abstract: A 42-year old man, 1 year previously diagnosed with ulcerative colitis after an emergency subtotal colectomy with formation of an ileostomy because of severe colitis with perforation, was admitted with sepsis and jaundice. The liver enzymes were elevated and blood cultures were positive for Streptococcus milleri. Magnetic resonance imaging showed a complete thrombosis of the main stem of the portal vein with occlusion of the left branch. Intravenous antibiotic therapy combined with heparinisation led to complete recanalisation of the thrombus. Portal vein thrombosis is a rare complication of inflammatory bowel disease and has been described in only 10 patients thus far. Multiple aetiologic factors may be responsible in relation to inflammatory bowel disease, such as hypercoagulability, thrombocytosis and abdominal sepsis. In patients with inflammatory bowel disease, unexplained sepsis and abnormal liver function tests, the possibility of an acute portal vein thrombosis should be considered and investigated, because unrecognised it may have serious long-term complications.
authors.affiliation: Department of Internal Medicine, Vrije University Medical Centre, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands. gs.mijnhout@vumc.nl
authors.forename: G S
authors.initials: GS
authors.lastname: Mijnhout
authors.forename: E C
authors.initials: EC
authors.lastname: Klinkenberg
authors.forename: G
authors.initials: G
authors.lastname: Lycklama
authors.forename: R
authors.initials: R
authors.lastname: Linskens
authors.forename: S G M
authors.initials: SG
authors.lastname: Meuwissen
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006502:Budd-Chiari Syndrome / Q000628:therapy; D003093:Colitis, Ulcerative / Q000150:complications*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008099:Liver / Q000503:physiopathology; D008297:Male; D011169:Portal Vein / Q000473:pathology; D018805:Sepsis / Q000209:etiology*; D034364:Streptococcus milleri Group / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents