Fully automated polymer-assisted synthesis of 1,5-biaryl pyrazoles.
The polymer-assisted solution-phase (PASP) synthesis of a 192-member 2-D array of 1,5-biaryl pyrazoles 4[1-12,1-16] is reported. The synthesis was performed in a fully automated manner using a multiprobe top-filtration robot and incorporates a "catch and release" step to afford library compounds directly in high yield and purity.
Vickerstaffe
Emma
E
GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.
Warrington
Brian H
BH
Ladlow
Mark
M
Ley
Steven V
SV
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009930:Organic Chemicals; D011108:Polymers; D011720:Pyrazoles; D012996:Solutions
D009930:Organic Chemicals; D011108:Polymers; D011720:Pyrazoles; D012996:Solutions