title: Synthesis and biodistribution of (99m)Tc-carbonyltechnetium-labeled fatty acids.
abstract: In order to image myocardial metabolism, (99m)Tc(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-imidazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of (99m)Tc(CO)(3)-IUA and (99m)Tc(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, PR China. twchu@pku.edu.cn
authors.forename: Taiwei
authors.initials: T
authors.lastname: Chu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xinqi
authors.initials: X
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Shaowen
authors.initials: S
authors.lastname: Hu
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D011877:Radionuclide Imaging; D013667:Technetium / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D005227:Fatty Acids; D007202:Indicators and Reagents; D013667:Technetium