title: Magnetic resonance low-dose dobutamine test is superior to SCAR quantification for the prediction of functional recovery.
abstract: BACKGROUND
  Low-dose dobutamine challenge (DSMR) by MRI was compared with delayed enhancement imaging with Gd-DTPA (SCAR) as a predictor of improvement of wall motion after revascularization (RECOVERY).
  
  
  RESULTS
  In 29 patients with coronary artery disease (68+/-7 years of age, 2 women, 32+/-8% ejection fraction), wall motion was evaluated semiquantitatively by MRI before and 3 months after revascularization. SCAR and DSMR were performed before revascularization. The transmural extent of scar was assessed semiquantitatively. Binary prediction of RECOVERY was performed by logistic regression in 288 segments with wall motion abnormalities at rest. Receiver operating characteristic-area under curve (AUC) statistics were used to compare different models. Low-dose DSMR (AUC 0.838) was superior to SCAR (AUC 0.728) in predicting RECOVERY. SCAR did not improve accuracy of prediction by DSMR. Subgroup analysis showed superiority of DSMR for 1% to 74% transmural extent of infarction.
  
  
  CONCLUSIONS
  Low-dose DSMR is superior to SCAR in predicting RECOVERY. This advantage is largest in segments with a delayed enhancement of 1% to 74%.
authors.affiliation: German Heart Institute, Internal Medicine/Cardiology, Berlin, Germany. Ewellnhofer@t-online.de
authors.forename: Ernst
authors.initials: E
authors.lastname: Wellnhofer
authors.forename: Adriana
authors.initials: A
authors.lastname: Olariu
authors.forename: Christoph
authors.initials: C
authors.lastname: Klein
authors.forename: Michael
authors.initials: M
authors.lastname: Gräfe
authors.forename: Andreas
authors.initials: A
authors.lastname: Wahl
authors.forename: Eckart
authors.initials: E
authors.lastname: Fleck
authors.forename: Eike
authors.initials: E
authors.lastname: Nagel
mesh_terms: D000368:Aged; D019540:Area Under Curve; D003327:Coronary Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery; D004280:Dobutamine / Q000008:administration & dosage; D005080:Exercise Test / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009204:Myocardial Revascularization; D017682:Myocardial Stunning / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D009206:Myocardium / Q000473:pathology; D015588:Observer Variation; D011446:Prospective Studies; D012372:ROC Curve; D011877:Radionuclide Imaging; D020127:Recovery of Function; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D018754:Ventricular Dysfunction / Q000175:diagnosis
chemical_list: D004280:Dobutamine; D019786:Gadolinium DTPA