Topiramate efficacy in an infant with partial seizures refractory to conventional antiepileptic drugs.
Many studies showed that Topiramate (TPM) may be a useful drug in a wide spectrum of childhood epilepsies. We report a 3-month-old female with stormy onset of secondarily generalized partial seizures. She showed a high seizure frequency and a progressive worsening electroencephalogram (EEG), despite standard antiepileptic drugs administration. TPM succeeded in controlling seizures, even after the other drugs were discontinued. This case suggests that TPM may represent a good choice for the treatment of partial seizures refractory to conventional drugs in infants.
Veggiotti
Pierangelo
P
Child Neuropsychiatry Department, Neurological Institute Casimiro Mondino Foundation IRCCS, University of Pavia, Pavia, Italy. pveggiot@unipv.it
Longaretti
Francesca
F
Signorini
Sabrina
S
Cardinali
Simonetta
S
Lanzi
Giovanni
G
D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose