title: [An advanced case of squamous cell carcinoma in the left buccal mucosa, upper gingiva, and maxillary sinus (T4N0M0) showing a complete response to chemotherapy with TS-1].
abstract: We report a case of advanced squamous cell carcinoma in the left buccal mucosa, upper gingiva, and maxillary sinus (T4N0M0) showing a complete response to oral chemotherapy with TS-1. The patient was an 89-year-old female with severe dementia. We carried out chemotherapy with TS-1 50 mg/day, without surgical treatment. The tumor disappeared clinically at 4 months after 3 courses of the TS-1 administration. Adverse drug reactions, including vomiting, leukopenia and thrombopenia, forced a stop of the administration of TS-1. Although she finally died of in senescence 2 months from the cease of administration, there was no recurrence of the cancer at the time.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Shimane University School of Medicine.
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Obara
authors.forename: Koichi
authors.initials: K
authors.lastname: Mishima
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yasuro
authors.initials: Y
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005887:Gingival Neoplasms / Q000473:pathology*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008444:Maxillary Sinus Neoplasms / Q000473:pathology*; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D009361:Neoplasm Invasiveness; D010094:Oxonic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D011725:Pyridines / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000009:adverse effects / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced; D014840:Vomiting, Anticipatory / Q000209:etiology
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid