Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats.
We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.
Suetsuna
Kunio
K
Department of Food Science and Technology, National Fisheries University, Yamaguchi 759-6595, Japan. syunei@tmu.edu.tw
Maekawa
Keisei
K
Chen
Jiun-Rong
JR
D000595:Amino Acid Sequence; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy; D007700:Kinetics; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D011918:Rats, Inbred SHR; D044648:Undaria / Q000737:chemistry*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004151:Dipeptides; D010936:Plant Extracts