title: Validation of the i-STAT handheld activated clotting time for use with bivalirudin.
abstract: Bivalirudin is being used more frequently as an anticoagulant in the cardiac catheterization laboratory. Newer devices, used to measure activated clotting time (ACT), have not been thoroughly tested for use with bivalirudin. One such device, the i-STAT ACT, measures the generation of activated thrombin to determine the level of anticoagulation. Our study demonstrated a high level of agreement between the i-STAT ACT and the Hemochron ACT in patients anticoagulated with bivalirudin. In addition, the i-STAT was shown to have an extremely high degree of reproducibility.
authors.affiliation: Department of Cardiology, Baylor University Medical Center, 621 N. Hall Street, Suite 500, Dallas, TX 75226, USA. JeffreSc@baylorhealth.edu
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Schussler
authors.forename: Stuart R
authors.initials: SR
authors.lastname: Lander
authors.forename: Laurie A
authors.initials: LA
authors.lastname: Wissinger
authors.forename: Azam
authors.initials: A
authors.lastname: Anwar
authors.forename: Michael S
authors.initials: MS
authors.lastname: Donsky
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Johnson
authors.forename: Ravi C
authors.initials: RC
authors.lastname: Vallabhan
authors.forename: Jason B
authors.initials: JB
authors.lastname: Wischmeyer
mesh_terms: D000925:Anticoagulants / Q000097:blood*; D001780:Blood Coagulation Tests / Q000295:instrumentation*; D006328:Cardiac Catheterization / Q000379:methods; D006629:Hirudins / Q000031:analogs & derivatives*; D006801:Humans; D010446:Peptide Fragments / Q000627:therapeutic use*; D019095:Point-of-Care Systems / Q000592:standards*; D011994:Recombinant Proteins / Q000627:therapeutic use*; D015203:Reproducibility of Results
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin