Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade.
Candida albicans grew in hyphal form in RPMI1640, however, addition of farnesol inhibited the formation. Farnesol did not affect the expression of mRNAs related to cAMP-EFG1 pathways. The mRNAs (HST7 and CPH1) in mitogen activated protein kinase (MAP) cascades were decreased in farnesol-treated cells, but CST20 was not. Furthermore, expression of general amino acid permease 1 (GAP1) was decreased by farnesol. We concluded that farnesol inhibits a MAP kinase cascades, and the suppression is a cause of interruption of hyphae formation.
Sato
Tatsuki
T
Department of Microbiology, Tohoku Pharmaceutical University, Sendai, Japan.
Watanabe
Toshihiko
T
Mikami
Takeshi
T
Matsumoto
Tatsuji
T
D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development*; D005204:Farnesol / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D025301:Hyphae / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000502:physiology
D000935:Antifungal Agents; D005204:Farnesol