[A case of advanced gastric cancer effectively treated by combined chemotherapy of paclitaxel (TXL) and CDDP].
The patient was a 73-year-old man with unresectable advanced gastric cancer and celiac and supraclavicular lymph node metastases. Neoadjuvant chemotherapy consisting of paclitaxel (TXL) and CDDP was administered. TXL (80 mg/m2) and CDDP (25 mg/m2) was administered weekly on day 1, 8 and 15 as 1 cycle. After 4 cycles of TXL/CDDP administration, the lymph node metastases and gastric tumor had decreased almost completely in size and distal partial gastrectomy was performed. After surgery, the patient was treated with 4 courses of TXL/CDDP and has survived without recurrence to the present. TXL/CDDP is associated with few adverse events in hospital visits, and is thought to be an effective chemotherapy against advanced gastric cancer.
Nagata
Naoki
N
Dept. of Surgery I, University of Occupational and Environmental Health, School of Medicine.
Inoue
Yuzuru
Y
Fukushima
Masayuki
M
Shibao
Kazunori
K
Tsurudome
Yosuke
Y
Higure
Aiichiro
A
Hirata
Keiji
K
Nakayama
Yoshifumi
Y
Okamoto
Kouji
K
Konishi
Tetsumi
T
Itoh
Hideaki
H
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005743:Gastrectomy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D017239:Paclitaxel; D002945:Cisplatin