A new cross-over region for hemogloboin-Lepore-Hollandia.
Hb Lepore-Hollandia, identified in a Thai patient, was found to be due to a new cross-over between IVS1-nt 42 and nt 56 of the delta- and beta-globin genes. This differs from a previous case which crossed-over between codon 22 and IVS1-nt 16. Two independent homologous unequal cross-over events account for these two Lepore-Hollandia genes.
Chan
Vivian
V
Au
Patrick
P
Yip
Ben
B
Chan
Tai-Kwong
TK
D005260:Female; D005803:Genes, Immunoglobulin / Q000235:genetics; D005914:Globins / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007438:Introns; D008297:Male
D006455:Hemoglobins, Abnormal; C477064:hemoglobin Lepore-Hollandia; D005914:Globins