[Role of fibrin D-dimer in acute coronary syndrome. Prospective study of 22 cases].
Fibrin D-dimer are the consequence of an excess of fibrinolysis. The raise of their level in coronary heart disease seems to be helpful to enhance the diagnosis of coronary ischemia. Prospective study over 4 months, including 22 patients (16 male, 6 female) divided in 2 subgroups: Group I: 10 patients investigated for stable angina Group II: 12 patients investigated for ACS without ST elevation. All patients underwent fibrin D-dimer dosage and coronarography. Fibrin D-dimer levels were higher in group II (924.5 ng/ml vs 703.9 ng/ml; p < 0.0001). In group II, 6 patients had ST depression with a level of fibrin D-dimer 879.5 ng/ml vs 969.6 ng/ml in the other 6 patients. We found a positive correlation between level of fibrin D-dimer and complexity of coronary lesions (1007 ng/ml in type C vs 675 ng/ml in type A lesions; p < 0.0001). Fibrin D-dimer seems highly implicated in coronary disease and if these results are confirmed by larger studies their routine dosage will be helpful in ACS.
Barakett
Nadia
N
Service de cardiologie, Hôpital Militaire de Tunis.
Ouaddour
Anissa
A
Lahidheb
Dhaker
D
Smiri
Zahreddine
Z
Mhenni
Hédi
H
Azzouzi
Foued
F
Hajlaoui
Nadhem
N
Salah
Othmane
O
Fehri
Wafa
W
Rahal
Nejib
N
Haouala
Habib
H
D000328:Adult; D000933:Antifibrinolytic Agents / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia; D011446:Prospective Studies
D000933:Antifibrinolytic Agents; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D