Synthesis and evaluation of oxazaborolidines for antibacterial activity against Streptococcus mutans.
Several representative oxazaborolidines have been synthesized and evaluated against S. mutans for antibacterial activity. This is the first reported antibacterial activity of this class of compounds. The minimal inhibitory concentration values ranged from 0.53 to 6.75 mM.
Jabbour
Adel
A
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, and Faculty of Dentistry, Institute of Dental Sciences, Hebrew University, Jerusalem 91120, Israel.
Steinberg
Doron
D
Dembitsky
Valery M
VM
Moussaieff
Arieh
A
Zaks
Batia
B
Srebnik
Morris
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001896:Boron Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013237:Stereoisomerism; D013295:Streptococcus mutans / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D001896:Boron Compounds; D006573:Heterocyclic Compounds, 1-Ring