[Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes].
OBJECTIVE
To study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.


METHODS
3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method.


RESULTS
Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes.


CONCLUSIONS
Liposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.
Mao
Sheng-jun
SJ
School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
Hou
Shi-xiang
SX
Jin
Hui
H
Zhang
Liang-ke
LK
Jiang-Bin
D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage*; D022781:Hepatocytes; D008081:Liposomes; D010316:Particle Size; D010743:Phospholipids; D013387:Succinic Anhydrides
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D013387:Succinic Anhydrides; D006034:Glycyrrhetinic Acid