title: CD8+CD38+ T cells but not HIV type 1 RNA viral load predict CD4+ T cell loss in a predominantly minority female HIV+ adolescent population.
abstract: The purpose of this study was to evaluate predictors of HIV-1 disease progression in a cohort of predominantly female and minority adolescents who had acquired their HIV-1 infections through sexual risk behaviors. Subjects were identified from the REACH cohort who were not on antiretroviral therapy for at least 1 year and whose baseline CD4(+) T cells were >300 cells/mm(3). Biomedical and demographic characteristics of the subjects at the start of the study period were evaluated as predictors of CD4(+) T cell loss in univariate and multivariate models. Two-thirds of the 99 subjects meeting the selection criteria were female and 87% were black or Hispanic similar to the REACH cohort as a whole. Higher absolute CD8(+) CD38(+) T cell counts at the start of the assessment period were associated with a greater rate of loss of CD4(+) T cells. HIV-1 RNA viral load was among other potential predictors of HIV-1 disease progression that had no association with the rate of CD4(+) T cell loss in this cohort. This study extends the observed association of higher CD8(+) CD38(+) T cells numbers being predictive of HIV-1 disease progression into predominantly female, minority youth.
authors.affiliation: Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA. cwilson@uab.edu
authors.forename: Craig M
authors.initials: CM
authors.lastname: Wilson
authors.forename: Jonas H
authors.initials: JH
authors.lastname: Ellenberg
authors.forename: Steven D
authors.initials: SD
authors.lastname: Douglas
authors.forename: Anna-Barbara
authors.initials: AB
authors.lastname: Moscicki
authors.forename: Christie A
authors.initials: CA
authors.lastname: Holland
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000378:metabolism*; D051997:ADP-ribosyl Cyclase 1; D000293:Adolescent; D000328:Adult; D001741:Black or African American; D015703:Antigens, CD / Q000378:metabolism*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016827:CD8 Antigens / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology; D006630:Hispanic or Latino; D006801:Humans; D008562:Membrane Glycoproteins; D008913:Minority Groups; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology*; D019562:Viral Load
chemical_list: D015703:Antigens, CD; D016827:CD8 Antigens; D008562:Membrane Glycoproteins; D012367:RNA, Viral; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1