Frequent ventricular premature beats increase blood pressure variability in rats.
OBJECTIVE
The present study was designed to test a hypothesis that nonfatal ventricular arrhythmia such as ventricular premature beats (VPB) is a contributing factor in the elevation of blood pressure variability (BPV).


METHODS
Blood pressure (BP) and electrocardiogram were continuously recorded. The relation between VPB and BPV was observed under conscious state in chronic myocardial infarction (MI) rats one month after ligation of the left coronary artery, and further verified under anesthetized state in rat model of ventricular arrhythmia produced by acute intravenous infusion of aconitine.


RESULTS
MI rats exhibited a big difference in the count and pattern of VPB, and were divided into no VPB, occasional VPB, and frequent VPB groups. Among the three groups, there were no differences in BP, heart period (HP), and MI size. However, BPV was markedly higher in frequent not occasional VPB rats, and HP variability (HPV) was larger in both frequent and occasional VPB rats, when compared with no VPB rats. In the whole population of MI rats, BPV was positively correlated with VPB and HPV, not with BP, HP and MI size. Infusion of aconitine had no effect on BP, HP, BPV, and HPV during the period without VPB. Frequent VPB after several minutes of aconitine infusion induced significant increase in BPV and HPV with no change in BP and HP. BPV was also positively correlated with VPB and HPV, not with BP and HP. Hemodynamics in aconitine-evoked ventricular tachycardia was characterized as lower BP, higher BPV, and higher HPV.


CONCLUSIONS
High BPV can be caused by frequent not occasional VPB in rats.
Miao
Chao-yu
CY
Department of Pharmacology, Second Military Medical University, Shanghai 200433, China. cymiao@citiz.net
Xu
Li-ping
LP
Liu
Jian-guo
JG
Xie
He-hui
HH
Yuan
Wen-jun
WJ
Su
Ding-feng
DF
D000157:Aconitine; D000818:Animals; D001794:Blood Pressure; D006339:Heart Rate; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017180:Tachycardia, Ventricular / Q000139:chemically induced / Q000503:physiopathology; D018879:Ventricular Premature Complexes / Q000209:etiology / Q000503:physiopathology*
D000157:Aconitine