title: Decreasing clinical efficacy of chloroquine in Ankazobe, Central Highlands of Madagascar.
abstract: The clinical efficacy of chloroquine was assessed in the Primary Health Centre of Ankazobe, Central Highlands of Madagascar. This study shows an increase in the level of chloroquine resistance with the appearance of early treatment failures and RIII resistance. Furthermore, the prevalence of clinical treatment failures is approaching the level of 25%, at which WHO recommends a change of first-line drug.
authors.affiliation: Laboratoire de Parasitologie et Bactériologie, Service de Santé de District, Ankazobe 108, Madagascar. merlinwillcox@doctors.org.uk
authors.forename: M L
authors.initials: ML
authors.lastname: Willcox
authors.forename: E
authors.initials: E
authors.lastname: Rakotondrazafy
authors.forename: R
authors.initials: R
authors.lastname: Andriamanalimanana
authors.forename: D
authors.initials: D
authors.lastname: Andrianasolo
authors.forename: P
authors.initials: P
authors.lastname: Rasoanaivo
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008270:Madagascar; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D002738:Chloroquine