title: Association between insulin resistance and GAD65-autoantibody levels--a pilot study in an adult non-diabetic population.
abstract: The aim of this pilot study was to investigate any association between insulin resistance (IR) and serum levels of autoantibodies against the glutamic acid decarboxylase (GAD65Ab) among adult non-diabetic subjects. Based on calculations of IR using the IR homeostasis model in a Swedish adult non-diabetic population (n = 756) participating in the WHO MONICA-study, an insulin sensitive group (n = 54, M/F:27/27) and an insulin resistant group (n = 46 M/F:24/22) were identified. Serum from the subjects were analysed for the presence of GAD65Ab. There was no significant difference in GAD65Ab levels between the groups. However, there was a correlation between IR and serum GAD65Ab within the insulin sensitive group (Spearman rho 0.4, p < 0.01). Our observation could indicate that IR could serve as an initiator or a progression factor in the autoimmune process in subjects predisposed to autoimmunity. This finding will be further investigated in a larger study including subjects with a continuum of IR.
authors.affiliation: Family Medicine, Department of Public Health and Clinical Medicine, Umeå University, S-901 85 Umeå, Sweden. mante.hedman@lvn.se
authors.forename: M H
authors.initials: MH
authors.lastname: Hedman
authors.forename: O
authors.initials: O
authors.lastname: Rolandsson
authors.forename: E
authors.initials: E
authors.lastname: Hägg
authors.forename: L
authors.initials: L
authors.lastname: Mincheva-Nilsson
authors.forename: B
authors.initials: B
authors.lastname: Lindahl
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007333:Insulin Resistance / Q000276:immunology*; D007527:Isoenzymes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D001323:Autoantibodies; D007527:Isoenzymes; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2