Immunosuppressive auronol glycosides from Artocarpus tonkinensis.
Activity-guided fractionation of the n-butanol extract from the leaves of Artocarpus tonkinensis led to the isolation of the auronol glycosides maesopsin 4-O-glucoside (1), as well as the new alphitonin-4-O-glucoside (2). These structures were identified on the basis of MS and NMR spectroscopic data. The lymphocyte stimulation test showed both compounds having immunosuppressive activity.
Thuy
T T
TT
Institute of Chemistry, National Center for Natural Science and Technology, Cau Giay, Hanoi, Vietnam.
Kamperdick
C
C
Ninh
P T
PT
Lien
T P
TP
Thao
T T P
TT
Sung
T V
TV
D031622:Artocarpus / Q000737:chemistry*; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D001572:Benzofurans; D005960:Glucosides; D006027:Glycosides; D007166:Immunosuppressive Agents; D007202:Indicators and Reagents; D010936:Plant Extracts; C485327:maesopsin 4-O-glucoside; D016572:Cyclosporine; D002392:Catechin