Dendritic cells and autoimmunity.
Dendritic cells (DC) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Because of their capacity to stimulate naive T cells, DC have a central role in the initiation of primary immune responses and are considered promising tools and targets for immunotherapy. Emerging data suggest a role for DC in initiating autoimmune attacks. Direct analysis of DC phenotypes and DC-T-cell interactions in rodent and human autoimmune diseases should shed light on how pathogenesis occurs, and suggest novel avenues of treatment aimed at alleviating deviant DC function.
Bayry
Jagadeesh
J
INSERM U430 and Université Pierre et Marie Curie, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, Paris 75006, France.
Thirion
Marina
M
Delignat
Sandrine
S
Misra
Namita
N
Lacroix-Desmazes
Sébastien
S
Kazatchkine
Michel D
MD
Kaveri
Srini V
SV
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology* / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology; D002450:Cell Communication / Q000276:immunology* / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D051379:Mice; D051381:Rats; D017634:Self Tolerance / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology