Prostatic acid phosphatase: a possible diagnostic marker of intravascular large B-cell lymphoma.
OBJECTIVE
Intravascular large B-cell lymphoma (IVL) has been treated as fever of unknown origin (FUO), and many patients have been treated inadequately based on incorrect diagnoses. We previously cares for a patient with IVL who tested positive for prostatic acid phosphatase (PAP), a marker of prostate cancer. Since then, we have regularly examined this mather when IVL was suspected to investigate the usefulness of PAP as a diagnostic marker for IVL. We retrospectively evaluated the usefulness of PAP as diagnostic marker of IVL.


METHODS
We reviewed the clinical courses of 5 patients with IVL (3 males, 2 females) in comparison with 23 controls with hematologic malignancies other than IVL.


RESULTS
Serum levels of PAP were elevated in all 5 patients with IVL and 2 of the 23 controls. The difference was statistically significant using a chi-squared test (p=0.0002). The sensitivity and specificity of PAP were 100% and 91%, respectively, in the diagnosis of IVL. Its serum levels were closely associated with disease status.


CONCLUSIONS
This study suggests that PAP might be a useful marker for the screening and assessment of disease activity and responses to the treatment of IVL.
Kishi
Yukiko
Y
Department of Hematology, Toranomon Hospital, Tokyo, Japan.
Kami
Masahiro
M
Kusumi
Eiji
E
Mineyama
Tomoka
T
Kato
Daisuke
D
Hamaki
Tamae
T
Ueyama
Jun-ichi
J
Miyakoshi
Shigesaburo
S
Morinaga
Shin-ichi
S
Muto
Yoshitomo
Y
Taniguchi
Shuichi
S
D000135:Acid Phosphatase; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004796:Clinical Enzyme Tests; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D017027:Protein Tyrosine Phosphatases / Q000097:blood*; D012189:Retrospective Studies; D019043:Vascular Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; C428439:prostatic acid phosphatase; D017027:Protein Tyrosine Phosphatases