[Studies on paclitaxel-loaded nanoparticles of amphiphilic block copolymer].
OBJECTIVE
To investigate the paclitaxel-loaded nanoparticles of poly(ethylene glycol)-b-poly(D,L-lactic acid) amphiphilic diblock copolymer (PMT).


METHODS
PMT was prepared by solid dispersion technique. The average size and size distribution were determined by dynamic light scattering (DLS). The morphology was characterized by transmission electron microscopy (TEM) and 1HNMR. The influences of the copolymer molecular weight and the paclitaxel-fed amount on PMT were studied. Therapeutic effect of PMT was studied on Kunming mice liver cancer H22.


RESULTS
PMT showed nanometer size and spherical morphology with core and shell. The sizes of PMT increased with increasing the molecular weight of the hydrophobic segment in PEDLLA or increasing the drug-loaded amount. The tumour inhibiting effect of PMT was similar with that of Taxol.


CONCLUSIONS
It will provide an experiment basis for the development of new kind of intravenous administration of paclitaxel.
Dong
An-jie
AJ
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. ajdong@tju.edu.cn
Deng
Lian-dong
LD
Sun
Duo-xian
DX
Zhang
Yue-ting
YT
Jin
Jian-zhou
JZ
Yuan
Ying-jin
YJ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D019344:Lactic Acid; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D008863:Microspheres; D036103:Nanotechnology; D017239:Paclitaxel / Q000008:administration & dosage* / Q000494:pharmacology; D010316:Particle Size; D011092:Polyethylene Glycols
D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D019344:Lactic Acid; D011092:Polyethylene Glycols; D017239:Paclitaxel