title: Steroidal saponins from Dioscorea panthaica and their cytotoxic activity.
abstract: A new steroidal saponin, dioscoreside E (1), and a known compound, protodioscin (2), were isolated from an ethanol extract of the rhizomes of Dioscorea panthaica. The structure of 1 was established as 3-O-[bis-alpha-L-rhamnopyranosyl-(1 --> 2 and 1 --> 4)-beta-D-glucopyranosyl]-26-O-beta-D-glucopyranosyl-20(R)-methoxy-25(R)-furosta-5,22(23)-diene-3beta,26-diol, on the basis of spectral and chemical evidence. Compounds 1 and 2 showed cytotoxic activity against a panel of tumor cell lines.
authors.affiliation: Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati, Ohio, USA.
authors.forename: M
authors.initials: M
authors.lastname: Dong
authors.forename: X Z
authors.initials: XZ
authors.lastname: Feng
authors.forename: B X
authors.initials: BX
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Ikejima
authors.forename: L J
authors.initials: LJ
authors.lastname: Wu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D027742:Dioscorea / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013256:Steroids; C485325:dioscoreside E