title: Efficacies of whole cell and acellular pertussis vaccines against Bordetella parapertussis in a mouse model.
abstract: Pertussis vaccine development has mainly focused on Bordetella pertussis, and consequently these vaccines contain B. pertussis antigens only. However, the related species Bordetella parapertussis can also cause pertussis, although symptoms associated with the disease are generally considered to be milder. Recent field studies have shown that in some outbreaks B. parapertussis can prevail. Using a mouse model we compared the efficacy against B. parapertussis of two commercially available acellular vaccines and two whole cell vaccines, used in The Netherlands and Finland, respectively. The efficacies of the two whole cell vaccines against B. parapertussis were similar, but much lower compared to the efficacy against B. pertussis. Although, the acellular vaccines conferred some protection against B. parapertussis early in infection, the values were not significant. Later in infection, a highly significant enhancement of colonisation by B. parapertussis was observed in mice vaccinated with acellular vaccines. The whole cell vaccines protected significantly better than the acellular vaccines against B. parapertussis. The possible consequences of a switch from whole cell to acellular vaccines was discussed in the light of our findings.
authors.affiliation: Research Laboratory for Infectious Diseases, National Institute Of Public Health and the Environment, P.O. Box 1, 3720 Bilthoven, The Netherlands.
authors.forename: Silke
authors.initials: S
authors.lastname: David
authors.forename: Ralph
authors.initials: R
authors.lastname: van Furth
authors.forename: Frits R
authors.initials: FR
authors.lastname: Mooi
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001884:Bordetella / Q000254:growth & development / Q000276:immunology*; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010567:Pertussis Vaccine / Q000276:immunology*; D014917:Whooping Cough / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D010567:Pertussis Vaccine