title: Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors.
abstract: A series of pyrazoline derivatives were prepared for evaluating their acyl-CoA:cholesterol acyltransferase activities. 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-5-(multi-substituted 4-hydroxyphenyl)-2-pyrazolines 4a-i were shown in vitro inhibitory activity on hACAT-1 and -2.
authors.affiliation: National Research Laboratory of Lipid Metabolism and Atherosclerosis, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, South Korea.
authors.forename: Tae-Sook
authors.initials: TS
authors.lastname: Jeong
authors.forename: Kyung Soon
authors.initials: KS
authors.lastname: Kim
authors.forename: Sojin
authors.initials: S
authors.lastname: An
authors.forename: So-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Kyung-Hyun
authors.initials: KH
authors.lastname: Cho
authors.forename: Sangku
authors.initials: S
authors.lastname: Lee
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D011720:Pyrazoles; D002785:Sterol O-Acyltransferase