title: Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
abstract: Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.
authors.affiliation: Idun Pharmaceuticals, Inc., 9380 Judicial Drive, San Diego, CA 92121, USA. slinton@idun.com
authors.forename: Steven D
authors.initials: SD
authors.lastname: Linton
authors.forename: Teresa
authors.initials: T
authors.lastname: Aja
authors.forename: Peter R
authors.initials: PR
authors.lastname: Allegrini
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Deckwerth
authors.forename: Jose-Luis
authors.initials: JL
authors.lastname: Diaz
authors.forename: Bastian
authors.initials: B
authors.lastname: Hengerer
authors.forename: Julia
authors.initials: J
authors.lastname: Herrmann
authors.forename: Kathy G
authors.initials: KG
authors.lastname: Jahangiri
authors.forename: Joerg
authors.initials: J
authors.lastname: Kallen
authors.forename: Donald S
authors.initials: DS
authors.lastname: Karanewsky
authors.forename: Steven P
authors.initials: SP
authors.lastname: Meduna
authors.forename: Kip
authors.initials: K
authors.lastname: Nalley
authors.forename: Edward D
authors.initials: ED
authors.lastname: Robinson
authors.forename: Silvio
authors.initials: S
authors.lastname: Roggo
authors.forename: Giorgio
authors.initials: G
authors.lastname: Rovelli
authors.forename: Andre
authors.initials: A
authors.lastname: Sauter
authors.forename: Robert O
authors.initials: RO
authors.lastname: Sayers
authors.forename: Albert
authors.initials: A
authors.lastname: Schmitz
authors.forename: Robert
authors.initials: R
authors.lastname: Smidt
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Ternansky
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Tomaselli
authors.forename: Brett R
authors.initials: BR
authors.lastname: Ullman
authors.forename: Christoph
authors.initials: C
authors.lastname: Wiessner
authors.forename: Joe C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D002219:Carbamates; D061945:Caspase Inhibitors; D002460:Cell Line; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007700:Kinetics; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D020521:Stroke / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D002219:Carbamates; D061945:Caspase Inhibitors; D004151:Dipeptides; C011960:oxamyl