SATE pronucleotide approaches: an overview.
This review depicts in vitro and in vivo results obtained with nucleotide prodrugs (pronucleotides) bearing S-acyl-2-thioethyl (SATE) groups as esterase-labile phosphate protections. New developments are illustrated by the design of mononucleoside mixed phosphoester derivatives leading to the selective intracellular delivery of the corresponding 5'-mononucleotide through two different enzyme-mediated activation steps.
Peyrottes
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S
UMR 5625 CNRS-UM II, Université Montpellier II, case courrier 008, place Eugène Bataillon, 34095 Montpellier cedex 05, France. perigaud@univ-montp2.fr
Egron
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D
Lefebvre
I
I
Gosselin
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G
Imbach
J-L
JL
Périgaud
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C
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010755:Organophosphates / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013997:Time Factors
D000998:Antiviral Agents; D009711:Nucleotides; D010755:Organophosphates; D011355:Prodrugs