title: Detection of cervical precancer and cancer in a hospital population; benefits of testing for human papillomavirus.
abstract: The aim was to determine the relevance of human papillomavirus (HPV) testing in identifying high-grade cervical intraepithelial neoplasia or worse (CIN2/3+) in a hospital population (n=3574) characterised by a high rate of cytological abnormalities and high-risk HPV infections. According to the results of the initial Papanicolaou and HPV test, women were directly referred for colposcopy/biopsy or recalled for a control visit. Sensitivity and specificity were corrected for verification bias. HPV-testing sensitivity was 94.3%, higher than that of cytological testing at any cut-off point (65.1%-86.8%), while specificity was greater for cytology than for HPV testing (99.3% or 91.8% versus 83.4%). The combination of both tests allowed 100% sensitivity and negative predictive value. We conclude that HPV testing is a relevant tool for the detection of cervical disease. The best way of combining cytology and HPV detection in screening programmes should be evaluated in large-scale studies.
authors.affiliation: Laboratoire de Biologie Cellulaire et Moléculaire, CHU de Besançon, Hôpital Jean Minjoz, 25030 Besançon cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Dalstein
authors.forename: D
authors.initials: D
authors.lastname: Riethmuller
authors.forename: J L
authors.initials: JL
authors.lastname: Sautière
authors.forename: J L
authors.initials: JL
authors.lastname: Prétet
authors.forename: B
authors.initials: B
authors.lastname: Kantelip
authors.forename: J P
authors.initials: JP
authors.lastname: Schaal
authors.forename: C
authors.initials: C
authors.lastname: Mougin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003127:Colposcopy / Q000592:standards; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000821:virology; D012680:Sensitivity and Specificity; D014412:Tumor Virus Infections / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000821:virology; D014626:Vaginal Smears / Q000592:standards; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000821:virology
chemical_list: D004279:DNA, Viral