EYE on bioinformatics: dissecting complex disease traits in silico.
Bioinformatics has provided an unprecedented power and resource for us to decipher the enigma of complex diseases. It can reveal otherwise promiscuous information from the tremendous amount of data generated by the new, powerful and high-throughput technologies of genomics and proteomics. In this paper, we review the cutting edge developments in complex disease trait mapping, databases, computational gene recognition, gene function prediction, pathway reconstruction and disease classification by expression profiling, and computational modelling of living systems. Integration of all this knowledge and the different technologies, alongside cooperation between experts from different fields, will enhance our understanding of the molecular and mechanistic abnormalities in disease state, and greatly assist the rational development of effective therapies.
Leung
Yuk Fai
YF
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong.
Pang
Chi Pui
CP
D002874:Chromosome Mapping; D019295:Computational Biology / Q000639:trends*; D003198:Computer Simulation; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000706:statistics & numerical data; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D023281:Genomics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D009154:Mutation; D020641:Polymorphism, Single Nucleotide