Overexpression of annexin 1 in pancreatic cancer and its clinical significance.
OBJECTIVE
To investigate the expression of annexin I in pancreatic cancer and its relationship with the clinicopathologic factors, and to evaluate its potential clinical significance.


METHODS
Annexin I expression was analyzed by Western blot and immunohistochemical staining in pancreatic adenocarcinoma and multi-tissue microarrays (MTAs).


RESULTS
Western blot analysis showed that annexin I was overexpressed in 84.6% (11/13) pancreatic ductal adenocarcinomas. Immunohistochemistry analysis of pancreatic cancer in MTAs showed that annexin I protein was 71.4%(30/42) positive which was markedly increased compared with that in the tumor matched normal pancreas tissues 18.4%(7/38) (P<0.01). In the meantime, the high expression of annexin 1 was correlated with the poor differentiation of pancreatic adenocarcinoma.


CONCLUSIONS
Annexin 1 overexpression is a frequent biological marker and correlates with the differentiation of pancreatic cancer during tumorigenesis.
Bai
Xiao-Feng
XF
National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Ni
Xiao-Guang
XG
Zhao
Ping
P
Liu
Shang-Mei
SM
Wang
Hui-Xin
HX
Guo
Bing
B
Zhou
Lan-Ping
LP
Liu
Fang
F
Zhang
Jin-Sheng
JS
Wang
Kun
K
Xie
Yong-Qiang
YQ
Shao
Yong-Fu
YF
Zhao
Xiao-Hang
XH
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000818:Animals; D017305:Annexin A1 / Q000378:metabolism*; D014408:Biomarkers, Tumor; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008875:Middle Aged; D010179:Pancreas / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D040081:Protein Array Analysis
D017305:Annexin A1; D014408:Biomarkers, Tumor