title: Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride.
abstract: An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.
authors.affiliation: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe St. Baltimore, Maryland 21205, USA.
authors.forename: Yousang
authors.initials: Y
authors.lastname: Hwang
authors.forename: Philip A
authors.initials: PA
authors.lastname: Cole
mesh_terms: D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010421:Pentanoic Acids / Q000737:chemistry*; D010766:Phosphorylation; D011355:Prodrugs / Q000138:chemical synthesis*
chemical_list: D009943:Organophosphorus Compounds; D010421:Pentanoic Acids; D011355:Prodrugs; C494260:bis-pivaloyloxymethyl phosphate