title: Histo-blood group type change of the graft from B to O after ABO mismatched heart transplantation.
abstract: A patient with blood group type O accidentally received a blood group B cardiac allograft. He died almost 5 years after transplantation because of transplant vasculopathy. We monitored the expression of ABO-type antigens on the vascular endothelial cells of the cardiac allograft for 44 months, using monoclonal antibodies for immunohistology. The antigenic profile of the graft endothelial cells changed progressively from B to O. This change was first detectable 14 months after transplantation and it was most prominent at the end of the observation period. Thus, we have shown that the allograft blood type of the endothelium of this patient's heart began to change from type B to his own, 1 year after transplantation. By 44 months post-transplantation, it had changed to O type.
authors.affiliation: Department of Cardiology, University Hospital Bern, Switzerland.
authors.forename: Simon C
authors.initials: SC
authors.lastname: Koestner
authors.forename: Andreas
authors.initials: A
authors.lastname: Kappeler
authors.forename: Thomas
authors.initials: T
authors.lastname: Schaffner
authors.forename: Thierry P
authors.initials: TP
authors.lastname: Carrel
authors.forename: Urs E
authors.initials: UE
authors.lastname: Nydegger
authors.forename: Paul
authors.initials: P
authors.lastname: Mohacsi
mesh_terms: D000017:ABO Blood-Group System / Q000032:analysis / Q000276:immunology; D000328:Adult; D001787:Blood Group Incompatibility; D002196:Capillaries / Q000276:immunology; D003331:Coronary Vessels / Q000276:immunology; D004699:Endocardium / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007150:Immunohistochemistry; D007518:Isoantibodies / Q000097:blood; D008297:Male
chemical_list: D000017:ABO Blood-Group System; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies