title: A new cross-over region for hemogloboin-Lepore-Hollandia.
abstract: Hb Lepore-Hollandia, identified in a Thai patient, was found to be due to a new cross-over between IVS1-nt 42 and nt 56 of the delta- and beta-globin genes. This differs from a previous case which crossed-over between codon 22 and IVS1-nt 16. Two independent homologous unequal cross-over events account for these two Lepore-Hollandia genes.
authors.forename: Vivian
authors.initials: V
authors.lastname: Chan
authors.forename: Patrick
authors.initials: P
authors.lastname: Au
authors.forename: Ben
authors.initials: B
authors.lastname: Yip
authors.forename: Tai-Kwong
authors.initials: TK
authors.lastname: Chan
mesh_terms: D005260:Female; D005803:Genes, Immunoglobulin / Q000235:genetics; D005914:Globins / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006801:Humans; D007438:Introns; D008297:Male
chemical_list: D006455:Hemoglobins, Abnormal; C477064:hemoglobin Lepore-Hollandia; D005914:Globins