title: In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
abstract: A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ikuta
authors.forename: Keiji
authors.initials: K
authors.lastname: Oi
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Abe
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Uwatoku
authors.forename: Fuminori
authors.initials: F
authors.lastname: Hyodo
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
authors.forename: Noboru
authors.initials: N
authors.lastname: Shigetani
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimitsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimokawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Utsumi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D020212:Carotid Artery Injuries / Q000175:diagnosis; D002404:Catheterization / Q000009:adverse effects; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D015195:Drug Design; D004730:Endothelium, Vascular / Q000473:pathology; D019786:Gadolinium DTPA / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats; D013552:Swine; D014018:Tissue Distribution; D014652:Vascular Diseases / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; C483332:EB-DTPA-Gd; D019786:Gadolinium DTPA