[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas].
OBJECTIVE
To explore the expression and significance of heat shock protein (HSP)70, 90 in endometrial carcinomas.


METHODS
Expresssions of HSP70 and HSP90 in 30 normal endometrium, 30 endometrial hyperplasia and 53 endometrial carcinomas were detected by Envision immunohistochemical staining and imaging pattern analyser.


RESULTS
Gray Scale value(GS) of HSP70 in endometrial carcinoma being (209.06+/-5.36) GS was obviously higher than that in normal endometrium (145.21+/-4.09)GS, P<0.01 and endometrial hyperplasia(148.59+/-4.23)GS, P<0.01. GS of HSP90 in endometrial carcinoma being (166.98+/-5.71)GS was markedly lower than that in normal endometrium (208.57+/-3.14)GS,P<0.05 and endometrial hyperplasia (249.73+/-4.94)GS, P<0.01. Expression of HSP70 increased with increased pathological grading of tumor P<0.01, whereas HSP90 expression decreased with increased pathological grading P<0.01. Expression of HSP70 in nonendometrioid carcinoma (229.90+/-3.77)GS was higher than in endometrioid carcinoma (198.37+/-3.15)GS,P<0.01 and the expression pattern of HSP90(140.21+/-3.22)was contrary to that of HSP70 (176.59+/-2.79)GS,P<0.01. There was no correlations among expression of HSP70, 90 in endometrial carcinoma and depth invaded into muscular layer, clinical stage and lymph node metastasis.


CONCLUSIONS
Both HSP70 and HSP90 may have relation to the genesis and prognosis of endometrial carcinoma.
Bai
Xiao-xia
XX
Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Chen
Ya-qiong
YQ
Xin
Xiao-yan
XY
Wang
Wen-dong
WD
D018269:Carcinoma, Endometrioid / Q000378:metabolism* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D006965:Hyperplasia; D011379:Prognosis
D018840:HSP70 Heat-Shock Proteins; D018841:HSP90 Heat-Shock Proteins