title: Hyperoxaemia does not change concentrations of serotonin and beta-thromboglobulin in blood of healthy humans.
abstract: BACKGROUND
  The mechanisms of oxygen-induced effects on blood vessels (vasoconstriction in hyperoxaemia and vasodilatation during hypoxaemia) are uncertain. Many investigators have suggested that the vasoconstriction seen during hyperoxia/hyperoxaemia is mediated through the endothelium as a result of either increased release or activity of vasoconstrictors (oxygen radicals, endothelin, norepinephrine, angiotensin II, or serotonin (5-HT)), or reduced activity of vasodilators (prostaglandin E2 and nitric oxide). Serotonin has been assumed to have a central role.
  
  
  METHODS
  Eight healthy volunteers were exposed to FiO2 of 1.0 for 20 min and serum concentrations of serotonin and activated platelets were measured (indicated by concentrations of beta-thromboglobulin (beta-TG)).
  
  
  RESULTS
  During hyperoxaemia in humans, serum concentrations of scrotonin and beta-TG remained unchanged.
  
  
  CONCLUSIONS
  If serotonin is involved in oxygen-induced vasoconstriction, the mechanism is more likely to be either a potentiating effect of serotonin on other vasoconstrictors or increased activity of serotonin on its receptor.
authors.affiliation: Department of Anaesthesiology and Intensive Care and the Burn Intensive Care Unit, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Rousseau
authors.forename: A
authors.initials: A
authors.lastname: Abdiu
authors.forename: F
authors.initials: F
authors.lastname: Sjöberg
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000097:blood*; D008297:Male; D012701:Serotonin / Q000097:blood*; D001620:beta-Thromboglobulin / Q000032:analysis*
chemical_list: D001620:beta-Thromboglobulin; D012701:Serotonin