The modular approach to ligand discovery.
Identifying specific protein-ligand interactions is a long-standing problem in drug discovery and chemical biology, which is only exacerbated by the abundance of uncharacterized proteins revealed by genomics. Last month in Chemistry Biology, Sem et al. described a powerful technique for rapidly screening protein families for ligands.
Karan
Charles
C
Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Room 622, Boston, MA 02115, USA.
Tallarico
John A
JA
D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008024:Ligands; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000145:classification* / Q000378:metabolism*
D008024:Ligands; D011506:Proteins