title: Singlet oxygen generation via two-photon excited FRET.
abstract: A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Dichtel
authors.forename: Jason M
authors.initials: JM
authors.lastname: Serin
authors.forename: Carine
authors.initials: C
authors.lastname: Edder
authors.forename: Jean M J
authors.initials: JM
authors.lastname: Fréchet
authors.forename: Michael
authors.initials: M
authors.lastname: Matuszewski
authors.forename: Loon-Seng
authors.initials: LS
authors.lastname: Tan
authors.forename: Tymish Y
authors.initials: TY
authors.lastname: Ohulchanskyy
authors.forename: Paras N
authors.initials: PN
authors.lastname: Prasad