Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations.
The choice of surfactant or surfactant mixtures at suitable concentrations contributes to the stability of solid lipid nanoparticles (SLN). In this study, it was found that 1.5% TegoCare 450 was the most effective stabilizer for the Witepsol E85 SLN dispersion compared to Tween 80, Tyloxapol and Pluronic F68 according to the data obtained from differential scanning calorimetry (DSC), zeta potential (ZP) measurements and particle size analysis.
Uner
M
M
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Turkey. melikeuner@yahoo.com
Wissing
S A
SA
Yener
G
G
Müller
R H
RH
D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003102:Colloids; D003460:Crystallization; D004355:Drug Stability; D008055:Lipids / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D013501:Surface-Active Agents / Q000737:chemistry*; D014280:Triglycerides
D003102:Colloids; D008055:Lipids; D013501:Surface-Active Agents; D014280:Triglycerides; C009683:witepsol