Cerebellum development and schizophrenia: an association study of the human homeogene Engrailed 2.
Epidemiological data and family studies in schizophrenia show that genetic factors contribute to the vulnerability to this disorder. The homeogene Engrailed 2 (EN2) is specifically involved in patterning the region that gives rise to the cerebellum and controls the plasticity of midbrain dopaminergic neurons. We carried out an association study for a CA repeat polymorphism located in the 3' region of the homeogene EN2. The subjects consisted of 165 patients with schizophrenia and 97 controls matched for age and ethnicity from a French Caucasian population. We found no significant association of schizophrenia with this bi-nucleotide repeat polymorphism of the EN2 gene.
Gourion
David
D
INSERM E117, SHU Sainte-Anne, 7 rue Cabanis, Paris, France. gourion@chsa.broca.inserm.fr
Leroy
Sophie
S
Bourdel
Marie-Chantal
MC
Goldberger
Céline
C
Poirier
Marie-France
MF
Olié
Jean-Pierre
JP
Krebs
Marie-Odile
MO
D000328:Adult; D000483:Alleles; D002531:Cerebellum / Q000503:physiopathology*; D042622:DNA Repeat Expansion / Q000235:genetics; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005801:Genes, Homeobox / Q000235:genetics*; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009473:Neuronal Plasticity / Q000502:physiology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology*; D000099266:Engrailed 2 Protein
D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D000099266:Engrailed 2 Protein