[Combined treatment for advanced laryngeal carcinoma].
OBJECTIVE
To assess the efficacy of the combined therapy for advanced laryngeal carcinoma.


METHODS
204 cases of advanced laryngeal carcinoma were treated in this department from 1984 to 1997. Patients were treated by surgery alone or combined therapy including of surgery, radiotherapy and chemotherapy.


RESULTS
The overall 3 and 5 year survival were 70.1% (143/204) and 61.8% (126/204) respectively. 5-year survival rate of the combined therapy group was 68.2% (90/132), whereas, 5-year survival was only 50.0% (36/72) for surgery alone group (P < 0.05). There was no statistical differences between surgery alone group and the combined therapy group in the local recurrences (P > 0.05) but distant metastases (P < 0.05). There were also no statistical differences between the preoperative radiotherapy group and the non-preoperative radiotherapy group in the terms of infection and fistula (P > 0.05).


CONCLUSIONS
The results suggest that the combined therapy was more effective than surgery alone for the treatment of the advanced laryngeal carcinoma. Preoperative radiotherapy did not increase the incidences of infection and fistula.
Ge
Jun-heng
JH
Department of Otorhinolaryngology, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, China. gejunheng1965@yahoo.com.cn
Zhao
Rui-li
RL
Hu
Jun-lan
JL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant