title: Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.
abstract: Cyclic tetrapeptide retrohydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors and evaluated the inhibitory activity and found that they have potential as anticancer drugs.
authors.affiliation: Faculty of Engineering, Kyushu Institute of Technology, Kitakyushu 808-8550, Japan. nishino@life.kyutech.ac.jp
authors.forename: Norikazu
authors.initials: N
authors.lastname: Nishino
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshikawa
authors.forename: Louis A
authors.initials: LA
authors.lastname: Watanabe
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kato
authors.forename: Binoy
authors.initials: B
authors.lastname: Jose
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Komatsu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sumida
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008024:Ligands; D051379:Mice; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D008024:Ligands; D009842:Oligopeptides; D010456:Peptides, Cyclic; D015032:Zinc