Extremely low frequency magnetic field effects on premorbid behaviors produced by cocaine in the mouse.
We investigated the premorbid behavioral changes produced by the administration of cocaine and acute exposure to extremely low frequency (ELF) magnetic field (MF) in the mouse. ICR mice received intraperitoneal injections of cocaine at two doses (65 and 70 mg/kg) and were subsequently exposed to one of eight ELF-MF fields (2, 3, 4, 8, 10, 15, 25, or 60 Hz) of about 20 G (2 mT) intensity immediately after injection. Twelve mice were used for each of applied cocaine dose and ELF-MF level. For a given dose of cocaine, the applied MF frequencies were randomly ordered, and blind tests were carried out in which the behavior observer did not know the frequencies of MF. The premorbid behaviors were defined in the ICR mice and their changes were observed over the exposure of various ELF-MFs. Our data show that the onset times of stop rearing and tonic-clonic seizure in the 4 Hz MF exposure group are significantly different from those of the sham group.
Kim
Jungdae
J
School of Physics, Seoul National University, Seoul, Korea. jade@phya.snu.ac.kr
Baik
Ku Youn
KY
Lee
Byung-Cheon
BC
Kang
Seog-Youn
SY
Shin
Sang-Hoon
SH
Soh
Kwang-Sup
KS
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000633:toxicity*; D004307:Dose-Response Relationship, Radiation; D008280:Magnetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
D003042:Cocaine