title: Human cortical perfusion and the arterial pulse: a near-infrared spectroscopy study.
abstract: BACKGROUND
  The pulsatile nature of the arterial pulse induces a pulsatile perfusion pattern which can be observed in human cerebral cortex with non-invasive near-infrared spectroscopy. The present study attempts to establish a quantitative relation between these two events, even in situations of very weak signal-to-noise ratio in the cortical perfusion signal. The arterial pulse pattern was extracted from the left middle finger by means of plethesmographic techniques. Changes in cortical perfusion were detected with a continuous-wave reflectance spectrophotometer on the scalp overlying the left prefrontal cortex. Cross-correlation analysis was performed to provide evidence for a causal relation between the arterial pulse and relative changes in cortical total hemoglobin. In addition, the determination of the statistical significance of this relation was established by the use of phase-randomized surrogates.
  
  
  RESULTS
  The results showed statistically significant cross correlation between the arterial and perfusion signals.
  
  
  CONCLUSIONS
  The approach designed in the present study can be utilized for a quantitative and continuous assessment of the perfusion states of the cerebral cortex in experimental and clinical settings even in situations of extremely low signal-to-noise ratio.
authors.affiliation: Department of Physiology Medical Sciences Building, Room 3232, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8 Canada. h.kwan@utoronto.ca
authors.forename: Hon C
authors.initials: HC
authors.lastname: Kwan
authors.forename: Anita
authors.initials: A
authors.lastname: Cheng
authors.forename: Ruth
authors.initials: R
authors.lastname: Liu
authors.forename: Donald S
authors.initials: DS
authors.lastname: Borrett
mesh_terms: D000293:Adolescent; D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D010991:Plethysmography / Q000379:methods; D011674:Pulse; D012016:Reference Values; D017550:Spectroscopy, Fourier Transform Infrared; D019265:Spectroscopy, Near-Infrared