[Expression of CGRP, ACTH and 5-HT in normal human lymph nodes].
OBJECTIVE
To detect the expression of calcitonin-gene-related peptide (CGRP), adrenocorticotropin (ACTH), and serotonin (5-HT) in normal human lymph nodes and explore their influences on immune system.


METHODS
The expression of CGRP, ACTH and 5-HT in the lymph nodes, including proliferative lymph nodes, were detected by SABC Immunohistochemical staining.


RESULTS
In 35 cases of lymph node specimens, the positive rates of CGRP, ACTH and 5-HT expression were 88.5%(31/35), 85.4%(30/35) and 94.2%(33/35) respectively. These 3 molecules had a similar distribution in germinal center of lymph nodes, mainly in the cells of paracortical region, the cells in germinal center of lymph follicles and macrophages, etc.


CONCLUSIONS
There are considerably high positive rates of CGRP, ACTH and 5-HT in human peripheral lymph nodes, and their distribution area are basically coincident with that of immunocytes in the lymph nodes.
Wang
Zhou
Z
Department of Pathology, Jinnng Medical College, Jining 272013, China.
Ji
Xiang-rui
XR
Li
Ji-feng
JF
Gao
Ji-fa
JF
Liang
Gui-hua
GH
D000324:Adrenocorticotropic Hormone / Q000032:analysis*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D005260:Female; D018858:Germinal Center / Q000737:chemistry; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry*; D008297:Male; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D015740:Calcitonin Gene-Related Peptide