[Pulmonary hyalinizing granuloma. Clinicopathologic study of 2 cases, with some original ultrastructural observations and review of the literature].
OBJECTIVE
To report the clinical, histological, immunohistochemical and ultrastructural features of 2 new cases of pulmonary hyalinizing granuloma.


RESULTS
Both patients were males: one, 72-year-old with retroperitoneal fibrosis, was asymptomatic, while the other, 67-year-old, presented with non productive cough. In both cases, a chest x-ray showed a solitary pulmonary nodule. Microscopically, the nodules were well circumscribed and composed of lamellae of hyalinized collagen. At the periphery, a more cellular rim consisting of lymphocytes, plasma cells and myofibroblasts was present. Immunohistochemical and ultrastructural examinations revealed myofibroblastic elements actively synthesizing collagen fibrils.
Vezzani
G
G
Unità Operative di Pneumologia, Università di Modena.
Cavazza
A
A
Rossi
G
G
Pasquinelli
G
G
Avanzini
P
P
Asioli
S
S
Piana
S
S
Chilosi
M
M
D000368:Aged; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D016726:Plasma Cell Granuloma, Pulmonary / Q000378:metabolism / Q000473:pathology*