[Alveolar damage of pneumocystis carinii pneumonia in renal transplantation recipients].
OBJECTIVE
To study the alveolar ultrastructural changes and the interaction between Pneumocystis carinii (PC) and alveoli in Pneumocystis carinii pneumonia (PCP) patients after renal transplantation.


METHODS
Twenty-seven patients with suspected PCP after renal transplantation were examinated by bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB). The BAL fluid was centrifuged and the sediments were stained for PC. Cases for which electron microscope showed alveolar tissue in TBLB specimen were included. Then the clinical features, PC, alveolar epithelial damage, exudate in alveolar space, inflammatory cell infiltration, and fibrous tissue in the interstitial space were analyzed and evaluated.


RESULTS
Twenty-three cases were studied. The mean time from renal transplantation to onset of illness was 5.6 months, and that from onset of illness to hospitalization was 5.5 days. Clinical features included fever, dyspnea, unproductive cough, and scanty chest signs, to hypoxemic respiratory failure. Chest CT showed diffuse lung interstitial changes in 22 of the 23 cases, 9 with consolidation. After treatment with SMZco, the fever resolved in 1 - 5 days, and the general state of the patients became better, and 19 patients were dischaged within 1 month. PC in BAL fluid was found by special staining in 18 patients, while PC was found by electron microscope in 14 patients. In most cases PC was few in the lung tissue, but in 3 cases abundant PC filled the alveolar space. PC was seen in two forms, the cyst and the trophozoite. Electron and light microscopes showed alveolar exudate, inflammation in interstitium and alveolar space, interstitial fibrosis, and alveolar epithelial damage in all patients.


CONCLUSIONS
In PCP patients after renal transplantation there was marked alveolar damage, which was the major pathological change in the lung.
Chen
Cheng-shui
CS
Department of Pulmonary, First Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Zheng
Shao-ling
SL
Fang
Zhou-xi
ZX
Li
Yu-ping
YP
Ye
Min
M
Zhang
Dong-qing
DQ
Xing
Ling-ling
LL
Chen
Shao-xian
SX
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation; D008168:Lung / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000382:microbiology / Q000473:pathology*; D011183:Postoperative Complications; D011650:Pulmonary Alveoli / Q000382:microbiology / Q000648:ultrastructure*