The use of alteplase for restoring patency to occluded central venous access devices in infants and children.
A 21-month retrospective review was completed at the Lucile Packard Children's Hospital to assess the experience of 22 infants and children who received alteplase for the clearance of occluded central venous access devices. After the first dose, 86% (n = 19) of the catheters cleared. Two additional catheters cleared with a second dose. With alteplase treatment, 95% (n = 21) of the catheters cleared. No adverse events were noted within 24 hours after the alteplase was received. Infusion of alteplase appeared to be safe and effective in restoring patency to occluded central venous access devices in infants and children.
Fisher
Amy A
AA
Lucile Packard Children's Hospital, Palo Alto, California 94305, USA.
Deffenbaugh
Claudia
C
Poole
Robert L
RL
Garcia
Manuel
M
Kerner
John A
JA
D000293:Adolescent; D000328:Adult; D002405:Catheterization, Central Venous / Q000451:nursing*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous / Q000451:nursing*; D008297:Male; D010371:Pediatric Nursing / Q000379:methods*; D012189:Retrospective Studies; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014654:Vascular Patency
D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator