Amino acid uptake in arterio-venous serum of normal and cancerous colon tissues.
OBJECTIVE
To investigate the difference of amino acid uptake between normal and cancerous colon tissues.


METHODS
Sixteen patients with colon cancer were enrolled in our study. Blood samples were taken during operations, serum amino acid concentrations of blood from cancerous or normal colon were analyzed. Amino acid uptake rate was calculated by the A-V difference and evaluated statistically.


RESULTS
Except for methionine, the uptake rate of amino acids in cancer was higher than that in normal colon (25.01% vs -2.29%, P<0.01). The amino acid uptake rate did not correlate to the size of tumor mass (P>0.05). There was no statistical significance in the amino acid uptake rate according to the Dukes stage, though it was higher in patients with Dukes stage C or D than that with Dukes stage B (P>0.05).


CONCLUSIONS
Abnormal synthetic metabolism of colon cancer may contribute to its higher amino acid uptake rate than that of normal colon.
Wang
Lin-Bo
LB
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, Zhejiang Province, China. wanglinbo@medmail.com.cn
Shen
Jian-Guo
JG
Zhang
Su-Zhan
SZ
Ding
Ke-Feng
KF
Zheng
Shu
S
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D001158:Arteries / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry*; D014680:Veins / Q000378:metabolism
D000596:Amino Acids