Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone.
A pellet formulation of progesterone in a self-emulsifying system (SES) was prepared by the process of extrusion/spheronization to provide a good in vitro drug release (100% within 30 min, T(50%) at 13 min). A three-way randomized crossover study was performed in six fasted male beagle dogs with these pellets and the same SES liquid formulation, both contained in a hard shell capsule, and an aqueous suspension. The same dose of progesterone (16 mg) in pellets and in the SES liquid formulation resulted in similar AUC, C(max) and T(max) values, estimated from progesterone plasma levels by (125)I radioimmunoassay. Although the maximum absorption was slightly retarded (0.5 to 1 h) by SES (pellets and liquid), AUC and C(max) were approximately seven and nine times greater then those obtained when an aqueous suspension formulation of the same dose of progesterone was administered to the same dogs. These results showed that it was possible to improve the bioavailability of the poorly soluble, poorly permeable progesterone when administered in SES. Moreover, presenting the progesterone in the form of a pellet did not prevent the release of the drug in vivo. These data demonstrate the utility of extrusion/spheronization in delivering a nonaqueous system in a novel solid dosage form.
Tuleu
Catherine
C
Department of Pharmaceutics, The School of Pharmacy, University of London, 29/39 Brunswick square, London WC1N 1AX, UK. catherine.tuleau@ulsop.ac.uk
Newton
Michael
M
Rose
Jayna
J
Euler
Danielle
D
Saklatvala
Robert
R
Clarke
Ashley
A
Booth
Steven
S
D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D004285:Dogs; D004343:Drug Implants; D045703:Emulsifying Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D008297:Male; D019999:Pharmaceutical Solutions / Q000138:chemical synthesis / Q000493:pharmacokinetics; D011374:Progesterone / Q000138:chemical synthesis / Q000493:pharmacokinetics*
D004343:Drug Implants; D045703:Emulsifying Agents; D019999:Pharmaceutical Solutions; D011374:Progesterone