title: Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat.
abstract: There is growing evidence that prenatal adversities could be implicated in foetal programming of adult chronic diseases. Since maternal stress is known to disturb the foetal glucocorticoid environment, we examined the consequences of prenatal stress on foetal growth, on glucose-insulin metabolism and on feeding behaviour in the aged male rat. In foetuses at term, maternal stress reduced body, adrenal and pancreas weight as well as plasma corticosterone and glucose levels. In aged male rats (24 months of age), prenatal stress induced hyperglycaemia and glucose intolerance and decreased basal leptin levels. Moreover, after a fasting period, they showed an increased food intake. These data suggest that maternal stress induces a long-lasting disturbance in feeding behaviour and dysfunctions related to type 2 diabetes mellitus. This programming could be linked to the early restricted foetal growth and to the adverse glucocorticoid environment in utero.
authors.affiliation: Laboratoire de Neuroendocrinologie du Développement, UPRES-EA 2701, Université de Lille 1, 59655 Villeneuve d'Ascq, France. jean.lesage@univ-lille1.fr
authors.forename: J
authors.initials: J
authors.lastname: Lesage
authors.forename: F
authors.initials: F
authors.lastname: Del-Favero
authors.forename: M
authors.initials: M
authors.lastname: Leonhardt
authors.forename: H
authors.initials: H
authors.lastname: Louvart
authors.forename: S
authors.initials: S
authors.lastname: Maccari
authors.forename: D
authors.initials: D
authors.lastname: Vieau
authors.forename: M
authors.initials: M
authors.lastname: Darnaudery
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology; D000375:Aging / Q000502:physiology*; D000818:Animals; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D003345:Corticosterone / Q000097:blood; D005247:Feeding Behavior; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D018149:Glucose Intolerance / Q000209:etiology*; D020738:Leptin / Q000097:blood; D008297:Male; D009929:Organ Size; D010179:Pancreas / Q000033:anatomy & histology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological / Q000150:complications*
chemical_list: D001786:Blood Glucose; D020738:Leptin; D003345:Corticosterone