Activation of the intracerebral cholinergic nerve fibers originating in the basal forebrain increases regional cerebral blood flow in the rat's cortex and hippocampus.
In the rat, activation of the intracerebral cholinergic system originating in the basal forebrain and projecting to the cortex and hippocampus releases acetylcholine in the cortex and hippocampus, which results in vasodilation and an increase in regional cerebral blood flow (rCBF) in the cortex and hippocampus. The augmentation of rCBF is independent of both systemic blood pressure and regional metabolism. The intracerebral cholinergic fibers are able to act as autonomic nerve fibers for the regulation of cortical and hippocampal blood flow.
Sato
Akio
A
University of Human Arts and Sciences, 1288 Magome, Iwatsuki, Saitama 339-8539, Japan. satoakio@jcom.home.ne.jp
Sato
Yuko
Y
Uchida
Sae
S
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D020532:Basal Nucleus of Meynert / Q000166:cytology / Q000502:physiology*; D002536:Cerebral Arteries / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply / Q000166:cytology / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002799:Cholinergic Fibers / Q000502:physiology* / Q000648:ultrastructure; D006624:Hippocampus / Q000098:blood supply / Q000166:cytology / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D009569:Nitric Oxide; D000109:Acetylcholine