Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism.
The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly increased if the STH-G allele was also present. The STH-G allele appears to be a risk modifier for AD.
Seripa
D
D
Laboratory of Gene Therapy, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy. dseripa@operapadrepio.it
Matera
M G
MG
D'Andrea
R P
RP
Gravina
C
C
Masullo
C
C
Daniele
A
A
Bizzarro
A
A
Rinaldi
M
M
Antuono
P
P
Wekstein
D R
DR
Dal Forno
G
G
Fazio
V M
VM
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007558:Italy; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012306:Risk; D012307:Risk Factors; D014015:Tissue Banks; D044465:White People / Q000235:genetics; D014922:Wisconsin / Q000208:ethnology; D016875:tau Proteins / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; C458340:STH protein, human; D016875:tau Proteins