A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour.
Tumour associated neovascularisation has been characterised as chaotic and insufficient. This report details the results of the analysis of angiogenic factors in tumour cyst fluid, pleural fluid, and blood from a patient with a gastrointestinal autonomic nerve tumour. The tumour produced vascular endothelial growth factor and endostatin in large quantities, which may explain the dysfunctional angiogenesis and tendency to bleeding seen in this tumour type.
Hansma
A H G
AH
Department of Medical Oncology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands.
van Hensbergen
Y
Y
Kuenen
B C
BC
van Diest
P J
PJ
Hanemaaijer
R
R
Meijer
S
S
Pinedo
H M
HM
Hoekman
K
K
D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000378:metabolism*; D043169:Endostatins / Q000096:biosynthesis*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000098:blood supply / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D010524:Peripheral Nervous System Neoplasms / Q000098:blood supply / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
D043169:Endostatins; D009363:Neoplasm Proteins; D042461:Vascular Endothelial Growth Factor A