title: Surface treatment of indomethacin agglomerates with eudragit.
abstract: Indomethacin is a widely used anti-inflammatory drug with serious side-effects. This drug was used as a model drug for the coating of agglomerates with a permeable film (Eudragit NE). The agglomeration of the crystals increased the flowability of the bulk crystals. The coating further improved the flowability, and also the uniformity of the mass of the filled capsules. The coating film also influenced the wetting of the samples. The coating decreased the surface free energy and therefore reduced the adhesion forces between both the dry and the wet particles. The modification of the flow properties and the even capsule filling can be explained by this phenomenon. Since coating film does not dissolve in the artificial gastric juice, the dissolution test was performed only in the artificial intestinal juice. The dissolution of indomethacin from the coated sample was changed significantly. Accordingly, coating of the crystals can be performed in order to protect the mucosa of the gastrointestinal tract or to promote the preparation of solid dosage form.
authors.affiliation: Department of Pharmaceutical Technology, University of Szeged, Szeged, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Bajdik
authors.forename: Klára
authors.initials: K
authors.lastname: Pintye-Hódi
authors.forename: Odon
authors.initials: O
authors.lastname: Planinsek
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Tüske
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Tasic
authors.forename: Géza
authors.initials: G
authors.lastname: Regdon
authors.forename: Stane
authors.initials: S
authors.lastname: Srcic
authors.forename: István
authors.initials: I
authors.lastname: Eros
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D007213:Indomethacin / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C477853:Eudragit NE 30-D; D008689:Methacrylates; D011108:Polymers; D007213:Indomethacin