Cardioprotective effects of carvedilol on acute autoimmune myocarditis.
We investigated whether carvedilol protects against experimental autoimmune myocarditis (EAM) attributing to antioxidant properties. Acute EAM was induced by porcine cardiac myosin in Lewis rats. We orally administered a vehicle, various dosages of carvedilol, metoprolol, or propranolol to rats with EAM for 3 weeks. Three beta-blockers decreased heart rates to the same extent. Carvedilol, but not metoprolol or propranolol, markedly reduced the severity of myocarditis at the two different dosages. Only carvedilol decreased the myocardial protein carbonyl contents, and also decreased the myocardial thiobarbituric acid reactive substance products in rats with EAM. Accordingly, carvedilol protects against acute EAM in rats, and this superior cardioprotective effect of carvedilol to metoprolol and propranolol may be due to the antioxidant properties in addition to the hemodynamic modifications.
Yuan
Zuyi
Z
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.
Shioji
Keisuke
K
Nimata
Masaomi
M
Kishimoto
Chiharu
C
D000284:Administration, Oral; D000818:Animals; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology*; D002227:Carbazoles / Q000008:administration & dosage*; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D000077261:Carvedilol; D004305:Dose-Response Relationship, Drug; D008790:Metoprolol / Q000008:administration & dosage; D009205:Myocarditis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D009218:Myosins / Q000008:administration & dosage / Q000276:immunology*; D011412:Propanolamines / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage; D011506:Proteins / Q000032:analysis; D051381:Rats; D011917:Rats, Inbred Lew; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D002227:Carbazoles; D002316:Cardiotonic Agents; D011412:Propanolamines; D011506:Proteins; D017392:Thiobarbituric Acid Reactive Substances; D000077261:Carvedilol; D011433:Propranolol; D009218:Myosins; D008790:Metoprolol