Development of a novel polyimide hollow-fiber oxygenator.
We have developed a membrane oxygenator using a novel asymmetric polyimide hollow fiber. The hollow fibers are prepared using a dry/wet phase-inversion process. The gas transfer rates of O(2) and CO(2) through the hollow fibers are investigated in gas-gas and gas-liquid systems. The polyimide hollow fiber has an asymmetric structure characterized by the presence of macrovoids, and the outer diameter of the hollow fiber is 330 microm. It is found that the polyimide hollow-fiber oxygenator can enhance the gas transfer rates of O(2) and CO(2), and that the hollow fiber provides excellent blood compatibility in vitro and in vivo.
Niwa
Motohiro
M
Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan.
Kawakami
Hiroyoshi
H
Nagaoka
Shoji
S
Kanamori
Toshiyuki
T
Morisaku
Kazuko
K
Shinbo
Toshio
T
Matsuda
Toshiaki
T
Sakai
Kazunari
K
Kubota
Sunao
S
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000378:metabolism; D004285:Dogs; D004867:Equipment Design; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000378:metabolism; D010107:Oxygenators, Membrane; D012117:Resins, Synthetic / Q000737:chemistry; D014684:Venae Cavae / Q000378:metabolism
D001672:Biocompatible Materials; D012117:Resins, Synthetic; D002245:Carbon Dioxide; C029945:polyimide resin; D010100:Oxygen