title: [The intermediate syndrome during organophosphorus pesticide poisoning].
abstract: Acute intoxication by organophosphate pesticides is frequent in Morocco. We report two cases of malathion poisoning complicated by intermediate syndrome. The purpose of this work is to describe distinctive features of this syndrome, it arises 48-96 h after the cholinergic crisis and it is characterized by respiratory paresis with difficulties of weaning from the assisted respiratory, deficit of proximal limbs, neck flexors, and cranial nerves. This syndrome coincides with the prolonged inhibition of the acetylcholinesterase, and is not due to the necrosis of muscular fiber's necrosis. Both clinical and electromyographic features are explained by a combined pre- and postsynaptic dysfunction of the neuromuscular transmission. The difficulty of this syndrome lies in its rarity and also its severity, because of the respiratory failure, which justifies medical supervision in intensive care unit, for at least 96 h, in expectation for the respiratory distress, all the more cholinergic syndrome is intense.
authors.affiliation: Service de réanimation médicale, CHU Ibn-Rochd, rue des Hôpitaux, Casablanca, Maroc. adbenslama@yahoo.fr
authors.forename: A
authors.initials: A
authors.lastname: Benslama
authors.forename: S
authors.initials: S
authors.lastname: Moutaouakkil
authors.forename: B
authors.initials: B
authors.lastname: Charra
authors.forename: L
authors.initials: L
authors.lastname: Menebhi
mesh_terms: D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000503:physiopathology; D003128:Coma / Q000139:chemically induced / Q000503:physiopathology; D004576:Electromyography; D005260:Female; D015600:Glasgow Coma Scale; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008294:Malathion / Q000506:poisoning*; D009018:Morocco; D009220:Myositis / Q000139:chemically induced / Q000503:physiopathology; D062025:Organophosphate Poisoning; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D010575:Pesticides / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy / Q000503:physiopathology; D012121:Respiration, Artificial; D012133:Respiratory Paralysis / Q000139:chemically induced; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D010575:Pesticides; D008294:Malathion