title: Synthesis and cytotoxicity of a novel 1-alkylaminomethyl-2,4-diaryl-butadiene-1,3 fragment integrated within cyclohex(pent)enes.
abstract: A group of 1-alkylaminomethyl-2-aryl-3-arylidenecyclohex(pent)enes 3a-n with a 1-alkylaminomethyl-2,4-diaryl-1,3-butadiene fragment and a group of their congeners 3-alkylaminomethyl-1,2-diarylcyclohexene 7a-f have been synthesised for the first time. The conjugated system in 1-alkylaminomethyl-2-aryl-3-arylidenecyclohex(pent)enes 3a-n was unambiguously confirmed by X-ray crystallography. Cytotoxicity tests revealed that 3a-n possess inconsistent cytotoxicity against cancer cells, not their congeners 7a-f.
authors.affiliation: School of Pharmacy, Aston University, Birmingham, B4 7ET, UK.
authors.forename: Kejun
authors.initials: K
authors.lastname: Zhao
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Linxiang
authors.initials: L
authors.lastname: Zhao
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Ji
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Tisdale
authors.forename: Carl H
authors.initials: CH
authors.lastname: Schwalbe
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002070:Butadienes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D003517:Cyclopentanes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002070:Butadienes; D003512:Cyclohexanones; D003517:Cyclopentanes