Unraveling the pathway of lipoic acid biosynthesis.
Lipoic acid is almost universally required for aerobic metabolism. However, the mechanism for its synthesis and incorporation into proteins has remained elusive. A groundbreaking study published in the December issue of Chemistry & Biology uncovers critical features of the lipoic acid biosynthetic pathway.
Booker
Squire J
SJ
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park 16802, USA.
D002384:Catalysis; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D008063:Thioctic Acid / Q000096:biosynthesis* / Q000378:metabolism
D008063:Thioctic Acid