title: Stable hepatocyte transplantation using fibrin matrix.
abstract: Fibrin matrix, a naturally derived biodegradable polymer matrix, was evaluated as a scaffold for hepatocyte transplantation in an athymic mouse model. One week after transplantation, opaque conglomerates of the transplanted hepatocytes and fibrin matrix were found on the intestinal mesentery, whereas no transplanted hepatocytes were observed in control groups (transplantation of hepatocytes suspended in culture medium). The hepatocytes in the conglomerates retained hepatocyte-specific functions, as examined with histochemical and immunohistochemical stainings. Stable hepatocyte engraftment may thus be achieved by hepatocyte transplantation using fibrin matrix.
authors.affiliation: Department of Chemical Engineering, College of Engineering, Hanyang University, Seoul, Korea.
authors.forename: So-Jung
authors.initials: SJ
authors.lastname: Gwak
authors.forename: Dongho
authors.initials: D
authors.lastname: Choi
authors.forename: Seung Sam
authors.initials: SS
authors.lastname: Paik
authors.forename: Eun Yeol
authors.initials: EY
authors.lastname: Lee
authors.forename: Kwang Soo
authors.initials: KS
authors.lastname: Lees
authors.forename: Byung-Soo
authors.initials: BS
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D005337:Fibrin; D022781:Hepatocytes / Q000637:transplantation*; D016031:Liver Transplantation / Q000379:methods; D051379:Mice; D023421:Models, Animal
chemical_list: D001672:Biocompatible Materials; D005337:Fibrin