title: Surgical construction of an in vivo carotid siphon model to test neurovascular devices.
abstract: OBJECTIVE
  We developed an animal model to evaluate vascular trauma induced by endovascular devices that are proposed for the treatment of cerebrovascular diseases.
  
  
  METHODS
  The model was constructed in six domestic swine by elongating the common carotid artery using interpositional grafts. Balloon catheters (n = 3), stents (n = 2), and a snare were tested 9 to 13 days after surgery. Device performance was evaluated by angiography, macroscopic photography, and histopathological examination.
  
  
  RESULTS
  Animals tolerated the surgical procedure well, and artificial siphons were thought to provide realistic conditions for device testing. Balloon catheters induced minimal trauma, whereas coronary stents caused severe spasm or thrombosis and extensive macroscopic changes.
  
  
  CONCLUSIONS
  Construction of an in vivo siphon model is feasible and potentially useful for testing neurovascular devices.
authors.affiliation: Department of Radiology, Notre-Dame Hospital, Montreal, Quebec, Canada.
authors.forename: Stavros A
authors.initials: SA
authors.lastname: Georganos
authors.forename: François
authors.initials: F
authors.lastname: Guilbert
authors.forename: Igor
authors.initials: I
authors.lastname: Salazkin
authors.forename: Guylaine
authors.initials: G
authors.lastname: Gévry
authors.forename: Jean
authors.initials: J
authors.lastname: Raymond
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D017130:Angioplasty / Q000295:instrumentation; D000818:Animals; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D002339:Carotid Arteries / Q000601:surgery*; D005260:Female; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D019635:Neurosurgical Procedures / Q000295:instrumentation*; D011093:Polyethylene Terephthalates; D015607:Stents; D013552:Swine
chemical_list: D011093:Polyethylene Terephthalates