title: Genetic and epigenetic analyses of MBD3 in colon and lung cancer.
abstract: MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cancers.
authors.affiliation: Sir Alastair Currie Cancer Research UK Laboratories, Division of Pathology, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhu
authors.forename: D J
authors.initials: DJ
authors.lastname: Harrison
authors.forename: S A
authors.initials: SA
authors.lastname: Bader
mesh_terms: D015152:Blotting, Northern; D003110:Colonic Neoplasms / Q000235:genetics*; D004252:DNA Mutational Analysis; D004268:DNA-Binding Proteins / Q000032:analysis / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: D004268:DNA-Binding Proteins; C115369:MBD3 protein, human