An iterative approach to novel polyamines via nucleophilic ring-opening of aziridinium ions with beta-amino alcohols.
An iterative procedure for the synthesis of a novel class of synthetic polyamines has been developed, utilising the regioselective ring-opening of aziridinium ion intermediates; facile N-allyl deprotection of intermediate polyamines allows the rapid construction of high molecular weight, stereochemically defined compounds in a convergent manner.
McKay
Christopher
C
Department of Chemistry, University of Leeds, Leeds, UK LS2 9JT.
Wilson
Robert J
RJ
Rayner
Christopher M
CM
D000605:Amino Alcohols / Q000737:chemistry*; D001388:Aziridines / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D015394:Molecular Structure; D008970:Molecular Weight; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D000605:Amino Alcohols; D001388:Aziridines; D007477:Ions; D011073:Polyamines