Dopamine antagonists do not block conditioned place preference induced by paced mating behavior in female rats.
The authors assessed the behavioral effects of dopamine (DA) receptor antagonists, Cis (Z) flupentixol and S(+)-raclopride L-tartrate, on conditioned place preference (CPP) induced by paced mating behavior. Ovariectomized female rats of the Wistar strain were used. The administration of amphetamine (1 mg/kg) induced a clear CPP that was completely blocked by the DA antagonists flupentixol (0.25 mg/kg) or raclopride (0.125 mg/kg). These doses had no effect on motor coordination. Female rats that mated in a pacing chamber developed a clear CPP. Neither flupentixol nor raclopride blocked the reward state induced by paced mating behavior. These results indicate that DA is not involved in the reward state induced by paced mating behavior in female rats.
García Horsman
Patricia
P
Institute de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, Mexico.
Paredes
Raúl G
RG
D000818:Animals; D002755:Choice Behavior; D003213:Conditioning, Psychological / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005475:Flupenthixol / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D020891:Raclopride / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D018492:Dopamine Antagonists; D020891:Raclopride; D005475:Flupenthixol