Immunomodulatory action of mycobacterial secretory proteins.
The recently discovered RD1 locus encodes proteins that are actively secreted by pathogenic mycobacteria, including Mycobacterium tuberculosis. Since they are missing in non-tuberculous mycobacteria, these proteins are promising not only as candidates for vaccination and diagnostic tests, but also in understanding mycobacterial evasion of protective immunity in susceptible individuals. Here we analyze the possible role of M. tuberculosis secretory proteins in immunity against tuberculosis, with emphasis on their immunomodulatory action and the potential involvement in mycobacterial subversion of the host immune defense.
Trajkovic
Vladimir
V
Immunology Group, International Center for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi 110067, India.
Natarajan
Krishnamurthy
K
Sharma
Pawan
P
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000378:metabolism; D001426:Bacterial Proteins / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000472:pathogenicity*; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology; D037521:Virulence Factors / Q000235:genetics / Q000276:immunology*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C117940:CFP-10 protein, Mycobacterium tuberculosis; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D037521:Virulence Factors