Cardiac IGF-I manipulation by growth hormone following myocardial infarction.
Evidence of a role for growth hormone (GH) in cardiac structure and function has been derived from studies of patients suffering either GH excess or deficiency, both of which may lead to reduced life expectancy. The role of GH in the ischaemic heart, however, is less than clear. We therefore investigated the effect of 30 days GH treatment in sheep with myocardial infarction. GH treatment significantly increased circulating IGF-I levels (P<0.01), heart weight (P<0.01), and cardiomyocyte cross-sectional area (P<0.001). IGF-I mRNA in peri-infarct cardiac tissue also increased significantly (P<0.05). We conclude that post-infarct GH treatment increases circulating and cardiac IGF-I levels, resulting in significant cardiomyocyte hypertrophy. This increase in cardiomyocyte size appears to correlate with local IGF-I expression rather than plasma IGF-I levels.
Matthews
K G
KG
Functional Muscle Genomics Group, AgResearch Ruakura, Private Bag 3123, East Street, Hamilton, New Zealand.
Devlin
G P
GP
Stuart
S P
SP
Conaglen
J V
JV
Bass
J J
JJ
D000818:Animals; D004195:Disease Models, Animal; D013006:Growth Hormone / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D009203:Myocardial Infarction / Q000097:blood / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D012756:Sheep / Q000378:metabolism
D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone