Solid-phase synthesis of constrained terminal and internal lactam peptidomimetics.
Lactams are key components of many peptidomimetic structures. Five- and six-membered lactam peptidomimetics with hydrogen or amino acid side chains at the alpha-position can be constructed from peptide precursors during a solid-phase synthesis. There is no significant racemization of remote stereocenters during synthesis.
Scott
William L
WL
Department of Chemistry, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA. wscott@chem.iupui.edu
Alsina
Jordi
J
Kennedy
Joseph H
JH
O'Donnell
Martin J
MJ
D003500:Cyclization; D007769:Lactams / Q000737:chemistry*; D018716:Molecular Mimicry; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry
D007769:Lactams; D010456:Peptides, Cyclic