title: Genetic polymorphisms of CYP1A1 in a Korean population.
abstract: Genetic polymorphisms in the coding exons of the CYP1A1 gene were analyzed in 100 Koreans. Three types of CYP1A1 polymorphisms, specifically G134A, G184C and A2455G, were identified with allelic frequencies of 18, 3, and 16%, respectively, and no linkage was observed among them. The novel G184C polymorphism identified in this study was associated with the mutation of an alanine residue at position 62 to proline. Other earlier-reported polymorphisms in the coding region of CYP1A1 were not detected.
authors.affiliation: College of Veterinary Medicine, Seoul National University, San 56-1, Sinlimdong, Kwanakgu, 151-742 Seoul, Korea.
authors.forename: Duk Woong
authors.initials: DW
authors.lastname: Park
authors.forename: Bohwan
authors.initials: B
authors.lastname: Jin
authors.forename: Dongdeuk
authors.initials: D
authors.lastname: Jang
authors.forename: Kihwa
authors.initials: K
authors.lastname: Yang
authors.forename: Jung-Duck
authors.initials: JD
authors.lastname: Park
authors.forename: Yong-Soon
authors.initials: YS
authors.lastname: Lee
authors.forename: Doug-Young
authors.initials: DY
authors.lastname: Ryu
mesh_terms: D000483:Alleles; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004247:DNA / Q000097:blood; D005091:Exons; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007723:Korea; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D004247:DNA; D019363:Cytochrome P-450 CYP1A1