title: Micronodular Kaposi's sarcoma - a new variant of classic-sporadic Kaposi's sarcoma.
abstract: Kaposi's sarcoma (KS) in its classic-sporadic form is a rare vascular neoplasm affecting predominantly elderly men of Jewish or Mediterranean origin. Women are very rarely affected by KS. The tumor manifests itself most commonly with brownish macular or infiltrated oval lesions on the lower legs in both genders. Human herpesvirus 8 (HHV-8) has recently been demonstrated to be etiologically linked to KS. We report a 51-year-old HIV-seronegative Caucasian woman with an unusual, previously not described variant of KS which presented with small (3 mm in diameter) scattered firm red papules on her right arm. The histology with nodular spindle cell tumor expressing endothelial markers, the demonstration of serum antibodies against HHV-8 and the presence of viral nucleic acids in the lesional tissue proved the diagnosis of the nodular stage of KS. An indolent course characterized by clinically identical seasonal recurrences, even after surgical treatment and cryosurgery, was observed during the follow-up period of 9 years. We propose the term 'micronodular KS' for this unusual clinical variant of KS mimicking capillary hemangioma.
authors.affiliation: Department of Dermatology, Institute for Clinical Pathology, University Hospital Zurich, Zurich, Switzerland. kempf@derm.unizh.ch
authors.forename: Werner
authors.initials: W
authors.lastname: Kempf
authors.forename: Gieri
authors.initials: G
authors.lastname: Cathomas
authors.forename: Günter
authors.initials: G
authors.lastname: Burg
authors.forename: Ralph M
authors.initials: RM
authors.lastname: Trüeb
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D001132:Arm; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D018324:Hemangioma, Capillary / Q000175:diagnosis; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000235:genetics; D012621:Seasons; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral