title: [A near-infrared diffuse reflectance analysis method for the noninvasive quantitative analysis of ambroxol hydrochloride tablets].
abstract: OBJECTIVE
  To develop a near-infrared diffuse reflectance analysis (NIRDRA) method for rapid noninvasive quantitative determination of ambroxol hydrochloride in half-finished product particles and non-blister-packed, blistered tablets.
  
  
  METHODS
  All spectra were measured with a Fourier transform spectrometer equipped with a PbS and a InGaAs detector, an external integrating sphere, a rotating sample cup, and a fibre-optic probe for reflectance measurements. All samples were scanned from 12,000 cm-1 to 4,000 cm-1, and each sample spectrum was obtained as an automatic mean of 64 scans. No spectrum pre-processing method was used, and spectral regions, 4,602-4,247, 12,000-7,498 and 6,102-5,446, 12,000-5,446 cm-1 were selected to develope mathematical models by partial least square method for half-finished product particles and non-blister-packed, blistered tablets samples, respectively.
  
  
  RESULTS
  The optimal rank and mean square error determined for half-finished product particles and non-blister-packed, blistered tablets samples by cross validation method all was 6 and 0.306, 0.972 and 1.492, respectively, the average recovery was 100%, 100% and 102% respectively; and the RSD was 1.17%, 1.70% and 1.78% respectively.
  
  
  CONCLUSIONS
  Results showed that the NIRDRA method was rapid, simple, noninvasive and sensitive, and it can be applied to assay the content of ambroxol hydrochloride in half-finished product particles non-blister-packed and blistered tablets.
authors.affiliation: Center for Instrumental Analysis, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Mei-ling
authors.initials: ML
authors.lastname: Sun
authors.forename: Bing-ren
authors.initials: BR
authors.lastname: Xiang
authors.forename: Deng-kui
authors.initials: DK
authors.lastname: An
mesh_terms: D000551:Ambroxol / Q000008:administration & dosage / Q000032:analysis*; D005100:Expectorants / Q000008:administration & dosage / Q000032:analysis*; D011786:Quality Control; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013607:Tablets
chemical_list: D005100:Expectorants; D013607:Tablets; D000551:Ambroxol