title: Galanin in the brain: chemoarchitectonics and brain cartography--a historical review.
abstract: We present a review of galanin in the brain from a historical perspective of the development of "chemoarchitectonics" and "brain cartography" accomplished in the Histopharmacology Section at the National Institutes of Health. It was the mapping of potential brain neuroregulators that served as a springboard of ideas from which behavioral studies emanate. The integration of the known localization of neurotransmitter/neuromodulatory nerves ("chemoarchitectonic maps") and receptor binding sites with biochemical data derived from brain micropunches coupled with behavioral analysis at the level of discrete brain allows one to define the anatomical circuits which support behavioral changes and which ultimately will improve our understanding of mental disorders.
authors.affiliation: Laboratory of Clinical Science, National Institute of Mental Health, National Institues of Health, Bethesda, MD 20892, USA. dwj@helix.nih.gov
authors.forename: David M
authors.initials: DM
authors.lastname: Jacobowitz
authors.forename: Adelheid
authors.initials: A
authors.lastname: Kresse
authors.forename: Gerhard
authors.initials: G
authors.lastname: Skofitsch
mesh_terms: D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D019004:Galanin / Q000235:genetics / Q000378:metabolism*; D007150:Immunohistochemistry; D018377:Neurotransmitter Agents / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011859:Radiography; D051381:Rats; D044088:Receptors, Galanin / Q000502:physiology; D013238:Stereotaxic Techniques
chemical_list: D018377:Neurotransmitter Agents; D012333:RNA, Messenger; D044088:Receptors, Galanin; D019004:Galanin