title: Drug release from carbomer:carbomer sodium salt matrices with potential use as mucoadhesive drug delivery system.
abstract: In vitro mucoadhesion, water uptake, and drug release of nystatin (N) from matrices of carbomer (C) and lyophilized carbomer sodium salt (CNaL) mixtures were evaluated. Matrices with different ratios C:CNaL were prepared by direct compression. Commercial C as well as lyophilized powder (CL) were used. In vitro mucoadhesion increased as the proportion of C in the matrix was raised. The same effect was observed when C was replaced by CL. Matrices in which C was replaced by CL showed an increase of both water uptake and release rates. Besides, the release of N from matrices CL:CNaL exhibited a kinetics with Super Case II (n>1) mechanism. However, for C:CNaL matrices, drug release was slower and exhibited a biphasic profile with a first stage characterized by either an anomalous (n<1, for C>or=50%) or a Case II (n approximately 1.0, C<50%) mechanisms. After that period, the mechanism changed to Super Case II transport (n>1).
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000 Córdoba, Argentina.
authors.forename: Juan M
authors.initials: JM
authors.lastname: Llabot
authors.forename: Ruben H
authors.initials: RH
authors.lastname: Manzo
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Allemandi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D009761:Nystatin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013607:Tablets; D014867:Water / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D000935:Antifungal Agents; D013607:Tablets; C479038:carbomer; D014867:Water; D009761:Nystatin