title: Complete response of multiple melanoma brain metastases after treatment with temozolomide.
abstract: BACKGROUND
  Inoperable melanoma brain metastases are usually uniformly fatal, and complete response after cytotoxic therapy is rare.
  
  
  METHODS
  A patient with multiple inoperable melanoma brain metastases was treated with 6 cycles of oral temozolomide (300 mg once daily over 5 days every 28 days). A complete response was documented by magnetic resonance.
  
  
  CONCLUSIONS
  The present observation suggests that temozolomide may be an active and well tolerated treatment for malignant melanoma brain metastases.
authors.affiliation: Department of Oncology and Radiotherapy, Charles University Medical School and Teaching Hospital, Hradec Králové, Czech Republic. dvorakj@fnhk.cz
authors.forename: J
authors.initials: J
authors.lastname: Dvorak
authors.forename: B
authors.initials: B
authors.lastname: Melichar
authors.forename: J
authors.initials: J
authors.lastname: Zizka
authors.forename: D
authors.initials: D
authors.lastname: Hadzi-Nikolov
authors.forename: J
authors.initials: J
authors.lastname: Petera
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008545:Melanoma / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D012074:Remission Induction; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D000077204:Temozolomide; D016896:Treatment Outcome
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide