title: Arterial injury repair in nonhuman primates-the role of PDGF receptor-beta.
abstract: BACKGROUND
  This study documents the time course of the response to injury of the saphenous artery in baboons and the role of the platelet-derived growth factor-beta. Fundamental differences with the well-characterized rat arterial injury model have been found.
  
  
  METHODS
  Thirty-eight baboons received a unilateral balloon injury to the saphenous artery and were treated with a chimeric blocking antibody to PDGFR-beta or vehicle control for 7, 14, or 28 days. The arteries were evaluated morphologically and for cell proliferation.
  
  
  RESULTS
  Both medial and intimal smooth muscle cell proliferation were elevated 7 days after injury and were back close to baseline at 14 days. Unlike the rat, blockade of PDGFR-beta inhibited medial proliferation over 80% at 7 and 14 days, while intimal proliferation was only inhibited at 14 days (>95%). Also, unlike the rat, the baboon arterial media, as well as the intima, increased in size by 14 days after injury. Blockade of PDGFR-beta completely inhibited both intimal and medial growth at 14 days, but there was less of an effect on intimal growth at 28 days.
  
  
  CONCLUSIONS
  Blockade of PDGFR-beta may be a clinical approach to inhibit intimal hyperplasia in humans, but this study raises concerns about the long-term efficacy of this treatment.
authors.affiliation: Department of Surgery, Division of Vascular Surgery, University of Washington Medical Center, Seattle, Washington, USA. englesbe@med.umich.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Englesbe
authors.forename: Mark G
authors.initials: MG
authors.lastname: Davies
authors.forename: Suzanne M
authors.initials: SM
authors.lastname: Hawkins
authors.forename: Patrick C H
authors.initials: PC
authors.lastname: Hsieh
authors.forename: Günter
authors.initials: G
authors.lastname: Daum
authors.forename: Richard D
authors.initials: RD
authors.lastname: Kenagy
authors.forename: Alexander W
authors.initials: AW
authors.lastname: Clowes
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood / Q000494:pharmacology; D001158:Arteries / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D002404:Catheterization / Q000009:adverse effects; D002455:Cell Division / Q000187:drug effects; D007866:Leg / Q000098:blood supply*; D008297:Male; D010215:Papio; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism*; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology; D017540:Tunica Media / Q000187:drug effects / Q000473:pathology; D014945:Wound Healing; D014947:Wounds and Injuries / Q000209:etiology
chemical_list: D000906:Antibodies; D020797:Receptor, Platelet-Derived Growth Factor beta