title: [Effects of ovarian stimulation on serum concentrations of lipids and ketone bodies in patients undergoing IVF/ICSI treatment].
abstract: OBJECTIVE
  The ovarian stimulation increase the estradiol concentration in comparison to the one observed in the menstrual cycle. The aim of the study was to determine the influence of ovarian stimulation on serum concentrations of lipids and ketone bodies in patients undergoing IVF/ICSI treatment.
  
  
  METHODS
  50 patients were included in this study. All patients underwent an ovarian stimulation either with recombinant follicle stimulating Hormone (Gonal-F, n = 28) or human menopausal gonadotropin (Menogon, n = 22) after pituitary down-regulation with Goserelin or Triptorelin. Five blood samples were taken: before treatment, at the beginning of ovarian stimulation, on the day of HCG injection for the ovulation induction, on the day of follicle aspiration and 14 days after embryo transfer. Afterwards, the samples were analysed with regard to the concentrations of triglyceride, total-cholesterol, HDL-/LDL-cholesterol, acetoacetate, beta-hydroxybutyrate and alpha-ketoglutarate.
  
  
  RESULTS
  During the ovarian stimulation, total-cholesterol andA'LDL-cholesterol decreased significantly (p(Chol) < or = 0.001; p(LDL) < or = 0.001), whereas the concentration of HDL-cholesterol increased significantly (p(HDL) < or = 0.001). Furthermore, a significant increase of beta-hydroxybutyrate and alpha-ketoglutarate has been detected (p(HBS) = 0.039; p (KG) = 0.023).
  
  
  CONCLUSIONS
  The observed changes in serum concentrations of lipids and ketone bodies began with the application of gonadotrophins for stimulation and persisted until the end of the treatment. Therefore, the increase of estradiol, stimulated by gonadotrophins, seems to be responsible for the changes in the serum concentrations of lipids and ketone bodies. All women undergoing ovarian stimulation should be monitored for long-term thrombogenic and atherogenic risks.
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe, Universität des Saarlandes, Homburg/Saar. frmham@uniklinik-saarland.de
authors.forename: M E
authors.initials: ME
authors.lastname: Hammadeh
authors.forename: W
authors.initials: W
authors.lastname: Munz
authors.forename: M
authors.initials: M
authors.lastname: Meisinger
authors.forename: W
authors.initials: W
authors.lastname: Herrmann
authors.forename: T
authors.initials: T
authors.lastname: Georg
authors.forename: P
authors.initials: P
authors.lastname: Rosenbaum
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood; D000090:Acetoacetates / Q000097:blood; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007656:Ketoglutaric Acids / Q000097:blood; D007657:Ketone Bodies / Q000097:blood*; D008055:Lipids / Q000097:blood*; D010062:Ovulation Induction; D020554:Sperm Injections, Intracytoplasmic; D014280:Triglycerides / Q000097:blood
chemical_list: D000090:Acetoacetates; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007656:Ketoglutaric Acids; D007657:Ketone Bodies; D008055:Lipids; D014280:Triglycerides; C016635:acetoacetic acid; D002784:Cholesterol; D020155:3-Hydroxybutyric Acid