Anti-inflammatory evaluation of Ionidium suffruticosam Ging. in rats.
The anti-inflammatory activity of Ionidium suffruticosam (Violaceae) methanol extract was evaluated on carrageenin, histamine and serotonin-induced rat hind paw oedema acute models. The extract at doses of 200 and 400 mg/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract at the dose level of 400 mg/kg exhibited maximum anti-inflammatory activity in all the animal models. In a chronic test, the extract (400 mg/kg) showed 42.78% reduction in granuloma weight. The effect produced by the extract was comparable to that of phenylbutazone, a proto type of a non-steroidal anti-inflammatory agent.
Boominathan
R
R
Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700 032, India.
Parimaladevi
B
B
Mandal
S C
SC
Ghoshal
S K
SK
D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D032561:Cotton Fiber; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D015745:Granuloma, Foreign-Body / Q000517:prevention & control; D006632:Histamine; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018514:Plant Structures; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin; D029649:Violaceae
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012701:Serotonin; D006632:Histamine; D002351:Carrageenan