title: Urinary beta-2 microglobulin in renal dysfunction associated with hypothyroidism.
abstract: Hypothyroidism is associated with a number of functional renal disorders primarily affecting water and salt handling. In this study, we aim to investigate functional renal disorders in overt and subclinical hypothyroidism. We utilised urinary beta-2 microglobulin (beta2M) as a sensitive marker of tubular dysfunction. Urinary beta2M excretion and tests for renal functions were repeated before and after T4 replacement therapy. Forty-four patients (28 with overt disease, 16 with subclinical disease) and 31 healthy control subjects were involved in the study. There was a significant increase in urinary beta2M in both overt and subclinical hypothyroidism (p < 0.05 in both). TSH levels were correlated with beta2M excretion. Effects of hypothyroidism on renal functions were readily reversible by 3 weeks of thyroid hormone replacement therapy. Urinary beta2M was a sensitive marker of renal tubular dysfunction associated with overt and subclinical hypothyroidism.
authors.affiliation: Faculty of Medicine, Department of Endocrinology, Yüzüncü Yil Universitesi, Van, Turkey. ekremalgun@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Algün
authors.forename: C
authors.initials: C
authors.lastname: Topal
authors.forename: M
authors.initials: M
authors.lastname: Oztürk
authors.forename: M Ramazan
authors.initials: MR
authors.lastname: Sekeroğlu
authors.forename: A
authors.initials: A
authors.lastname: Durmuş
mesh_terms: D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000652:urine; D007674:Kidney Diseases / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D001613:beta 2-Microglobulin / Q000652:urine*
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin