title: [Comparative studies on pharmacological effects of angong niuhuang pill with its simplified prescicription].
abstract: OBJECTIVE
  Based on the therapeutic claims of Angong Niuhuang pill, a series of pharmacodynamic experiments were designed, where pharmacological effects were investigated comparatively with its simplified prescription(realgar and cinnabar are removed from the original pill) as a parallel control in order to explore possible contribution of cinnabar and realgar to pharmacodynamic activities of the pill as a whole.
  
  
  METHODS
  Anti-pyretic, sedative, anti-convulsive, and mice-protected effects of the pill and its simplified prescription as a control were observed, respectively, in rabbits with fever induced by typhoid bacillus, in pentobarbital sodium-induced sleeping mice, in mice with convulsion induced by strychnine, or pentylenetetrazole, and in mice with anoxia induced by NaNO2.
  
  
  RESULTS
  Both the pill and its simplified prescription were found to have Anti-pyretic action and protective effect against the mouse death induced by anoxia, and synergistic interaction with pentobarbital sodium in sedative activity, although neither of them was found to have any effects on the convulsion of mice.
  
  
  CONCLUSIONS
  No significant difference between Angong Niuhuang pill and its simplified prescription was found in the above pharmacodynamic experiments.
authors.affiliation: Institute of Chinese Materia Medica, Chinese Academy of Traditional Chinese Medicine, Beijing 100700, China.
authors.forename: Zu-guang
authors.initials: ZG
authors.lastname: Ye
authors.forename: Jin-hua
authors.initials: JH
authors.lastname: Wang
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Liang
authors.forename: Bao-yun
authors.initials: BY
authors.lastname: Xue
authors.forename: Yue-sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Chun-ying
authors.initials: CY
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Huang
authors.forename: Ai-ying
authors.initials: AY
authors.lastname: Jin
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001152:Arsenicals / Q000494:pharmacology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D017669:Mercury Compounds / Q000494:pharmacology; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D013440:Sulfides / Q000494:pharmacology
chemical_list: D018712:Analgesics, Non-Narcotic; D000927:Anticonvulsants; D001152:Arsenicals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006993:Hypnotics and Sedatives; D008419:Materia Medica; D017669:Mercury Compounds; D013440:Sulfides; C058317:arsenic disulfide; C034211:cinnabar