title: Intrauterine growth retardation: study of placental apoptosis.
abstract: We studied the rate of apoptosis in the placental tissue of pregnancies complicated with intrauterine growth retardation (IUGR) and compared it with the results obtained in normal placentas. Our results clearly demonstrate a strongly increased rate of apoptosis in placentas of children born with IUGR, suggesting severe placental dysfunction. The significance of these findings needs further study.
authors.affiliation: Department of Molecular Genetics, University Children's Hospital Miguel Servet, Zaragoza, Spain. barrioeva@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Barrio
authors.forename: M T
authors.initials: MT
authors.lastname: Calvo
authors.forename: A
authors.initials: A
authors.lastname: Romo
authors.forename: R
authors.initials: R
authors.lastname: Alvarez
authors.forename: J I
authors.initials: JI
authors.lastname: Gutiérrez
authors.forename: J
authors.initials: J
authors.lastname: Naval
authors.forename: A
authors.initials: A
authors.lastname: Ferrández Longás
mesh_terms: D017209:Apoptosis; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology*; D018922:HL-60 Cells; D006801:Humans; D020287:In Situ Nick-End Labeling / Q000379:methods; D011247:Pregnancy; D014327:Trophoblasts / Q000473:pathology* / Q000648:ultrastructure*