Verb and noun generation tasks in Huntington's disease.
We compared noun- and verb-generation tasks in a demented group (n = 9, Dementia Rating Scale < or = 129) and in a non-demented group (n = 17, Dementia Rating Scale > 129) of Huntington's disease (HD) patients compared to 26 matched normal subjects. We did not find a specific deficit for verb production in non-demented patients who had a performance similar to but weaker than that of the controls across the four tasks. The profile of results was different in the demented group because, apart from a global deficit whatever the task in comparison with both non-demented and control groups, the demented patients exhibited increased difficulties in the two tasks implying verb production. The deficit of verb production observed in demented HD patients is discussed in relation to the damage to the motor loop in HD patients at later stages of disease.
Péran
Patrice
P
Institut National de la Santé et de la Recherche Médicale U 455, Fédération de Neurologie, Centre Hospitalier Universitaire Purpan, Toulouse, France. patrice.peran@toulouse.inserm.fr
Démonet
Jean-François
JF
Pernet
Cyril
C
Cardebat
Dominique
D
D001039:Aphasia, Broca / Q000175:diagnosis* / Q000209:etiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D009483:Neuropsychological Tests; D009687:Nuclear Proteins; D011506:Proteins / Q000235:genetics; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000503:physiopathology; D014825:Vocabulary
C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D011506:Proteins