Improved outcome of polyoma virus allograft nephropathy with early biopsy.
Polyoma virus allograft nephropathy often results in accelerated graft loss despite reduction of immunosuppression and/or treatment with antiviral agents. Irreversible renal fibrosis due to late diagnosis is likely to be one of the important causes of treatment failure. Early biopsy in 14 patients resulted in stable graft function after a mean follow-up of 22 months.
Drachenberg
C B
CB
Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Papadimitriou
J C
JC
Wali
R
R
Nogueira
J
J
Mendley
S
S
Hirsch
H H
HH
Cangro
C B
CB
Klassen
D K
DK
Weir
M R
MR
Bartlett
S T
ST
Ramos
E
E
D001706:Biopsy; D003404:Creatinine / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011120:Polyomavirus / Q000235:genetics / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000473:pathology*; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D003404:Creatinine