title: Simulation of five intracellular C2+-regulation mechanisms in response to voltage-clamp pulses.
abstract: We report the simulation of five C2+ regulation mechanisms in response to voltage-clamp pulses applied at the membrane. We obtain the currents generated and also record the C2+ concentration changes in the whole cell during and after the pulse. Our simulator includes models for the L-type voltage-dependent C2+ channels, the C2+ pump, the Na+/C2+ exchanger and a fast buffering system, along with diffusion assuming a spheric cell shape.
authors.affiliation: Applied Chemistry Area, Universidad Autónoma Metropolitana Campus Azcapotzalco, Mexico. vgv@correo.azc.uam.mx
authors.forename: V
authors.initials: V
authors.lastname: González-Vélez
authors.forename: J R
authors.initials: JR
authors.lastname: Godínez-Fernández
mesh_terms: D000465:Algorithms; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D003198:Computer Simulation; D008954:Models, Biological; D018408:Patch-Clamp Techniques; D019831:Sodium-Calcium Exchanger / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D019831:Sodium-Calcium Exchanger; D000252:Calcium-Transporting ATPases; D002118:Calcium