title: [Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes].
abstract: OBJECTIVE
  To study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.
  
  
  METHODS
  3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method.
  
  
  RESULTS
  Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes.
  
  
  CONCLUSIONS
  Liposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.
authors.affiliation: School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
authors.forename: Sheng-jun
authors.initials: SJ
authors.lastname: Mao
authors.forename: Shi-xiang
authors.initials: SX
authors.lastname: Hou
authors.forename: Hui
authors.initials: H
authors.lastname: Jin
authors.forename: Liang-ke
authors.initials: LK
authors.lastname: Zhang
authors.lastname: Jiang-Bin
mesh_terms: D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage*; D022781:Hepatocytes; D008081:Liposomes; D010316:Particle Size; D010743:Phospholipids; D013387:Succinic Anhydrides
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D013387:Succinic Anhydrides; D006034:Glycyrrhetinic Acid