Xenobiotic gene polymorphisms and susceptibility to multiple myeloma.
Genetic variations in the activity of xenobiotic enzymes may predict susceptibility to multiple myeloma (MM). In a case-control study, 90 Australian Caucasians with MM had significantly higher incidences of GST T1 null, PON1 BB and NAT2 slow acetylation genotypes, but no difference in polymorphism frequencies for GST M1, NAT1, and CYP1A1 when compared to 205 controls.
Lincz
Lisa F
LF
Kerridge
Ian
I
Scorgie
Fiona E
FE
Bailey
Michael
M
Enno
Arno
A
Spencer
Andrew
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000235:genetics; D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D015262:Xenobiotics
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase; D043303:Aryldialkylphosphatase