title: Farnesol, a morphogenetic autoregulatory substance in the dimorphic fungus Candida albicans, inhibits hyphae growth through suppression of a mitogen-activated protein kinase cascade.
abstract: Candida albicans grew in hyphal form in RPMI1640, however, addition of farnesol inhibited the formation. Farnesol did not affect the expression of mRNAs related to cAMP-EFG1 pathways. The mRNAs (HST7 and CPH1) in mitogen activated protein kinase (MAP) cascades were decreased in farnesol-treated cells, but CST20 was not. Furthermore, expression of general amino acid permease 1 (GAP1) was decreased by farnesol. We concluded that farnesol inhibits a MAP kinase cascades, and the suppression is a cause of interruption of hyphae formation.
authors.affiliation: Department of Microbiology, Tohoku Pharmaceutical University, Sendai, Japan.
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Sato
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mikami
authors.forename: Tatsuji
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development*; D005204:Farnesol / Q000494:pharmacology*; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D025301:Hyphae / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000502:physiology
chemical_list: D000935:Antifungal Agents; D005204:Farnesol