title: Subcutaneous phaeohyphomycotic abscess caused by Pleurophomopsis lignicola.
abstract: A 41-year-old man with a past medical history of diabetes mellitus type II, AIDS (diagnosed 2 years earlier; CD4 count < 10), peripheral neuropathy, and pulmonary tuberculosis of 2 years duration was admitted to the hospital with abnormal liver function tests. There was a chronic hepatitis/cholestasis that had worsened while the patient was undergoing directly observed tuberculosis therapy. On admission, the patient complained of a painful swelling on his right arm. In the posterior aspect of the arm, there was a 3-4-cm subcutaneous mass that was fluctuant, mobile and tender. Incision of the mass released yellowish pus mixed with blood. Direct examination of the pus in KOH mounts and Gram-stained smears revealed subhyaline, septate, branched hyphae. When the pus was cultured on Sabouraud dextrose agar containing chloramphenicol, several velvety, olivaceous grey colonies grew after 7 days at 25 degrees C. When grown on oatmeal agar, the fungus produced subglobose, rostrate pycnidia with phialidic conidiogenous cells, and 1-celled cylindrical conidia. It was identified as Pleurophomopsis lignicola Petrak. This report describes the third known case of subcutaneous infection caused by P. lignicola in an immunocompromized patient.
authors.affiliation: Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. aapadhye@msn.com
authors.forename: A A
authors.initials: AA
authors.lastname: Padhye
authors.forename: A
authors.initials: A
authors.lastname: Karpati
authors.forename: S A
authors.initials: SA
authors.lastname: Rosenthal
authors.forename: E
authors.initials: E
authors.lastname: Punithalingam
mesh_terms: D000038:Abscess / Q000382:microbiology* / Q000473:pathology; D000328:Adult; D003881:Dermatomycoses / Q000276:immunology / Q000382:microbiology*; D005658:Fungi / Q000254:growth & development / Q000302:isolation & purification* / Q000648:ultrastructure; D006801:Humans; D016867:Immunocompromised Host; D008297:Male