title: MK-801 does not prevent development of ischemic tolerance in rat brain.
abstract: Tolerance against ischemia can be induced in the CA1 region of the hippocampus of the brain. In gerbils tolerance evolvement is blocked by the NMDA-antagonist MK-801. To examine this mechanism in rats, MK-801 was administered i.p. 1 h prior to tolerance inducing ischemia. Body temperature and activity were monitored before and after ischemia, and show that MK-801 results in hyperthermia immediately after the injection, the post-ischemic body temperature remain elevated until 5 h post-ischemia in spite of the animals being less active than control animals. Histology shows that pre-treatment with MK-801 does not affect the CA1 neuronal density, and we thus conclude that for the used rat model, MK-801 does not affect development of ischemic tolerance.
authors.affiliation: Laboratory of Molecular Neuropathology, University of Copenhagen, Frederik V's vej 11, 6th floor, 2100 Copenhagen OE, Denmark. mw@nepa.ku.dk
authors.forename: Maria L
authors.initials: ML
authors.lastname: Wrang
authors.forename: Nils H
authors.initials: NH
authors.lastname: Diemer
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D016291:Dizocilpine Maleate / Q000494:pharmacology* / Q000633:toxicity; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D016291:Dizocilpine Maleate