Effect of dosing and sampling time on serum thyroxine, free thyroxine, and thyrotropin concentrations in dogs following multidose etodolac administration.
Thirty-eight dogs with orthopedic disorders received etodolac, an NSAID, at 10.0 to 13.3 mg/kg PO once daily for 14 to 19 days. Mean total thyroxine (T4), free thyroxine (fT4), and canine thyrotropin (cTSH) values before and after etodolac administration were compared using paired t-tests. A significant (P <.05) decrease in T4 values occurred after etodolac administration with 21% of these values falling below the reference range. A significant (P <.05) increase in cTSH following etodolac administration, but none of the values was above the reference range. No significant changes occurred in mean fT4 values; however, 10% of the values fell below the reference range. In conclusion, T4 and fT4 test results should be interpreted with caution in dogs receiving etodolac.
Ness
Timothy A
TA
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
Torres
Sheila M
SM
Kramek
Elizabeth A
EA
Blauvelt
Melissa M
MM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D004334:Drug Administration Schedule; D017308:Etodolac / Q000008:administration & dosage*; D005260:Female; D008297:Male; D010003:Osteoarthritis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D017308:Etodolac; D013972:Thyrotropin; D013974:Thyroxine