Receptor-dependent coronavirus infection of dendritic cells.
In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.
Turner
Brian C
BC
Department of Microbiology, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA.
Hemmila
Erin M
EM
Beauchemin
Nicole
N
Holmes
Kathryn V
KV
D000818:Animals; D015703:Antigens, CD; D039521:CD11c Antigen / Q000032:analysis; D002272:Carcinoembryonic Antigen; D015815:Cell Adhesion Molecules; D002460:Cell Line; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000821:virology*; D006023:Glycoproteins / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D006517:Murine hepatitis virus / Q000472:pathogenicity*; D011991:Receptors, Virus / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D039521:CD11c Antigen; C069847:CD66 antigens; D002272:Carcinoembryonic Antigen; C486183:Ceacam1 protein, mouse; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D011991:Receptors, Virus