title: Increased serum level of p-selectin in patients with lichen planus.
abstract: Lichen planus (LP) is a common, pruritic and inflammatory disease of the skin, hair follicles and mucous membranes. Immunologic mechanisms, especially cell-mediated immunity, play a major role in triggering the clinical expression of the disease. P-selectin is an adhesion molecule present within endothelial cells and mediates endothelial-leukocyte interactions. Therefore, it is considered that P-selectin plays an important role in LP. The aim of our study is to research the relation between P-selectin and LP. Serum P-selectin levels were determined with the enzyme- linked immunosorbent sandwich assay method in sera from 40 LP patients and 40 healthy controls. The serum levels of P-selectin were statistically significantly higher in the patients than in healthy controls (p < 0.05), in female patients (39.32 +/- 11.34 pg/ml) than in male patients (31.93 +/- 9.83 pg/ml) (p < 0.01), and in the patients with eruptive form (40.27 +/- 9.32 pg/ml) than in those with the localised (32.83 +/- 9.93 pg/ml) and hypertrophic (31.72 +/- 8.39 pg/ml) forms (both p < 0.01). In conclusion, we found a meaningful relation between LP and serum P-selectin levels.
authors.affiliation: Department of Dermatology, Ataturk University Medicine, 25240 Erzurum, Turkey. mterdem@hotmail.com
authors.forename: Teoman
authors.initials: T
authors.lastname: Erdem
authors.forename: A Ihsan
authors.initials: AI
authors.lastname: Güleç
authors.forename: Akin
authors.initials: A
authors.lastname: Aktaş
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildirim
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kiziltunç
mesh_terms: D000328:Adult; D015415:Biomarkers; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*
chemical_list: D015415:Biomarkers; D019007:P-Selectin