[Effect of trimetazidine on regressione of ischemic dysfunction of myocardium after coronary bypass surgery on beating heart].
OBJECTIVE
To study effect of trimetazidine on restoration of hibernating myocardium after myocardial revascularization on beating heart.


METHODS
Patients with ischemic heart disease subjected to direct myocardial revascularization on beating heart: 25 patients received trimetazidine (60 mg/day) in pre and postoperative periods and 30 patients did not.


METHODS
Echocardiography, veloergometry, 6 minute walk test, myocardial scintigraphy with Tl-199.


RESULTS
Course (35 days) treatment with trimetazidine provided significant decrease of frequency and severity of episodes of angina, reduction of nitrate consumption, enhancement of tolerance to physical exercise, improvement of myocardial perfusion manifested as significant decrease of mean size of transient perfusion defects.


CONCLUSIONS
These results demonstrate efficacy and expediency of trimetazidine use in therapy of reversible myocardial dysfunction in patients with ischemic heart disease subjected to direct myocardial revascularization.
Tepliakov
A T
AT
Research Institute for Cardiology of the Research Centre of RAMS Siberian Branch; ul. Kievskaya, 111, 634012 Tomsk, Russia.
Dzhavadova
G K
GK
Akhmedov
Sh D
ShD
Vecherskiĭ
Iu Iu
IuIu
Vesnina
Zh V
ZhV
D001026:Coronary Artery Bypass; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000188:drug therapy; D009206:Myocardium; D014292:Trimetazidine / Q000008:administration & dosage
D014292:Trimetazidine