Use of the Vitek-1 and Vitek-2 systems for detection of constitutive and inducible macrolide resistance in group B streptococci.
A prospective study of erythromycin and clindamycin resistance was performed with 304 consecutive group B streptococci (GBS) isolates. According to two automated susceptibility testing systems, Vitek-1 and Vitek-2, and double-disk agar diffusion, 79.9% were susceptible to both erythromycin and clindamycin. However, for macrolide-lincosamide-streptogramin B-inducible isolates, the accuracies of the Vitek-1 and Vitek-2 systems were 5.6 and 94.4%. In light of these results, we recommend that GBS be routinely tested using the double-disk diffusion method.
Tang
Patrick
P
Department of Microbiology, Toronto Medical Laboratories and Mount Sinai Hospital, and University of Toronto, Ontario, Canada.
Ng
Peter
P
Lum
Ming
M
Skulnick
Martin
M
Small
Glen W
GW
Low
Donald E
DE
Sarabia
Alicia
A
Mazzulli
Tony
T
Wong
Katherine
K
Simor
Andrew E
AE
Willey
Barbara M
BM
D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods* / Q000706:statistics & numerical data; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013290:Streptococcal Infections / Q000150:complications / Q000382:microbiology; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000302:isolation & purification
D018942:Macrolides; D002981:Clindamycin; D004917:Erythromycin