Antimalarial activity of lavandulyl flavanones isolated from the roots of Sophora flavescens.
Four lavandulyl flavanones, (2S)-2'-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (-)-kurarinone (4), which are isolated from the roots of Sophora flavescens have been tested for in vitro antimalarial activity against Plasmodium falciparum. Compounds 1-3 showed moderate antimalarial activities with EC(50) values of 2.4 x 10(-6), 2.6 x 10(-6), and 2.1 x 10(-6) M, respectively. These compounds did not show selective toxicity against P. falciparum in the toxicity test on mouse mammalian tumor cells, however, it is suggested that the position of methoxyl groups in flavanone skeleton plays an important role on antimalarial activity.
Kim
Youn Chul
YC
College of Pharmacy, Wonkwang University, Iksan, Korea.
Kim
Hye-Sook
HS
Wataya
Yusuke
Y
Sohn
Dong Hwan
DH
Kang
Tai Hyun
TH
Kim
Myung Soo
MS
Kim
Yong Man
YM
Lee
Geon-Mok
GM
Chang
Jong-Duk
JD
Park
Hyun
H
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects / Q000502:physiology; D029909:Sophora
D000962:Antimalarials; D044950:Flavanones