title: The diploid genome sequence of Candida albicans.
abstract: We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
authors.affiliation: Stanford Genome Technology Center, Palo Alto, CA 94304, USA.
authors.forename: Ted
authors.initials: T
authors.lastname: Jones
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Federspiel
authors.forename: Hiroji
authors.initials: H
authors.lastname: Chibana
authors.forename: Jan
authors.initials: J
authors.lastname: Dungan
authors.forename: Sue
authors.initials: S
authors.lastname: Kalman
authors.forename: B B
authors.initials: BB
authors.lastname: Magee
authors.forename: George
authors.initials: G
authors.lastname: Newport
authors.forename: Yvonne R
authors.initials: YR
authors.lastname: Thorstenson
authors.forename: Nina
authors.initials: N
authors.lastname: Agabian
authors.forename: P T
authors.initials: PT
authors.lastname: Magee
authors.forename: Ronald W
authors.initials: RW
authors.lastname: Davis
authors.forename: Stewart
authors.initials: S
authors.lastname: Scherer
mesh_terms: D002176:Candida albicans / Q000235:genetics*; D004171:Diploidy; D016681:Genome, Fungal; D006579:Heterozygote