title: Cardiogenic hypertrophic osteopathy in a dog with a right-to-left shunting patent ductus arteriosus.
abstract: A 5-year-old castrated male Shetland Sheepdog was examined because of progressive bilateral hind limb thickening. Cyanosis of the preputial mucous membranes was evident, whereas the oral mucous membranes had a normal color. A well-structured, palisade-like periosteal reaction with no underlying bone destruction was evident on radiographs of the hind limbs. The radiographic changes were consistent with hypertrophic osteopathy (HO). Severe right-sided cardiomegaly was seen on thoracic radiographs, and a diagnosis of patent ductus arteriosus with right-to-left shunting was made by means of echocardiography and contrast echoaortography. The cyanotic heart disease was believed to be the cause of the HO. Hypertrophic osteopathy has been associated with a number of diseases in animals and humans. In humans, congenital heart defects that cause cyanosis are among the most common causes of HO.
authors.affiliation: Affiliated Veterinary Specialists, 275 Corporate Way, Ste 100, Orange Park, FL 32073, USA.
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Anderson
authors.forename: Mark C
authors.initials: MC
authors.lastname: Walker
authors.forename: Robert L
authors.initials: RL
authors.lastname: Goring
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000000981:diagnostic imaging / Q000662:veterinary; D003490:Cyanosis / Q000209:etiology / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D004285:Dogs; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D004452:Echocardiography / Q000662:veterinary; D006614:Hindlimb / Q000000981:diagnostic imaging / Q000473:pathology; D015576:Hyperostosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary*; D008297:Male; D010021:Osteopathic Medicine; D013902:Radiography, Thoracic / Q000662:veterinary