In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.
Yamamoto
Tatsuhiro
T
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Ikuta
Kenjiro
K
Oi
Keiji
K
Abe
Kohtaro
K
Uwatoku
Toyokazu
T
Hyodo
Fuminori
F
Murata
Masaharu
M
Shigetani
Noboru
N
Yoshimitsu
Kengo
K
Shimokawa
Hiroaki
H
Utsumi
Hideo
H
Katayama
Yoshiki
Y
D000818:Animals; D001011:Aorta / Q000473:pathology; D020212:Carotid Artery Injuries / Q000175:diagnosis; D002404:Catheterization / Q000009:adverse effects; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D015195:Drug Design; D004730:Endothelium, Vascular / Q000473:pathology; D019786:Gadolinium DTPA / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats; D013552:Swine; D014018:Tissue Distribution; D014652:Vascular Diseases / Q000175:diagnosis*
D003287:Contrast Media; C483332:EB-DTPA-Gd; D019786:Gadolinium DTPA