Dysbindin-1 and schizophrenia: from genetics to neuropathology.
The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.
Owen
Michael J
MJ
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom. owenmj@cf.ac.uk
Williams
Nigel M
NM
O'Donovan
Michael C
MC
D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D020022:Genetic Predisposition to Disease; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D026901:Membrane Transport Proteins; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D017729:Presynaptic Terminals / Q000378:metabolism; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D014018:Tissue Distribution; D050598:Vesicular Glutamate Transport Protein 1; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D026901:Membrane Transport Proteins; C493464:SLC17A7 protein, human; D050598:Vesicular Glutamate Transport Protein 1; D033921:Vesicular Transport Proteins; D018698:Glutamic Acid