Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton.
Bioassay-guided fractionation of an extract prepared from Alangium javanicum using an assay to monitor Cu(2+)-dependent DNA strand scission led to the isolation of javaniside, a new type of oxindole glycoside.
Ma
Ji
J
Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22901, USA.
Hecht
Sidney M
SM
D032604:Alangiaceae; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification
D007211:Indoles; D010936:Plant Extracts; D004247:DNA