[An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba].
OBJECTIVE
To study the active components and their functionary mechanism of the extract of Brassica alba seeds, which inhibits experimental mice prostatic hyperplasia.


METHODS
Prostatic hyperplasia of castrated male mice induced by testosterone propionate, the penetrability of capillary vessel of mice skin induced by histamine and the endermic flesh bud of rat induced by filter paper were used as experimental models. Sinalbin and beta-sitosterol separated from seeds of Brassica alba were used to test the activities.


RESULTS
Sinalbin and beta-sitosterol(16.0 mg.kg-1.d-1 and 8.0 mg.kg-1.d-1) could significantly inhibit mice prostatic hyperplasia induced by testosterone propionate and activity of serum acid phosphatase(P < 0.01 or P < 0.05), Sinalbin(16.0 mg.kg-1.d-1)could significantly inhibit the hyperplasia of endermic flesh bud in rat induced by filter paper(P < 0.05), beta-sitosterol(16.0 mg.kg-1.d-1 and 8.0 mg.kg-1.d-1) could significantly decrease the penetrability of capillary vessel of mice skin induced by histamine.


CONCLUSIONS
Sinalbin and beta-sitosterol have anti-androgen and anti-inflammation activities.
Wu
Guo-xin
GX
Bioengineering College, Fujian Normal University, Fuzhou 350007, Fujian, China. wugx20021@sina.com
Lin
Yue-xin
YX
Ou
Min-rui
MR
Tan
Dong-fei
DF
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009149:Mustard Plant / Q000737:chemistry; D009919:Orchiectomy; D010946:Plants, Medicinal / Q000737:chemistry; D011470:Prostatic Hyperplasia / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D012855:Sitosterols / Q000302:isolation & purification / Q000494:pharmacology*; D043343:Testosterone Propionate
D000726:Androgen Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012855:Sitosterols; C025473:gamma-sitosterol; D002794:Choline; D043343:Testosterone Propionate; C003313:sinalbin