Susceptibility of the influence of weight on blood pressure in men versus women: lessons from a large-scale study of young adults.
BACKGROUND
Weight and blood pressure (BP) are closely related. The aim of this study was to quantify this relationship and compare it to other factors in a population of relatively young adults, with particular focus on the possible role of gender.


METHODS
We conducted a cross-sectional analysis of the Young Adult Periodic Examinations in Israel (YAPEIS) database of healthy people aged 25 to 45 years undergoing routine periodic examinations. Between 1991 and 1999, 38,558 subjects (88.1% men, mean age 36 +/- 8 years) were examined. The correlation between BP and weight was evaluated with adjustments for age, sex, physical activity, cigarette smoking, and fasting blood glucose levels.


RESULTS
Blood pressure correlated positively with body mass index (BMI), spanning the spectrum of BMI values. Weight accounted for 8% to 10% of BP variance. The odds ratio for hypertension increased by 16% for each additional unit of BMI, compared to 6% for each year increase in age. The relative propensity of men toward hypertension, typical of this age group, was less pronounced at higher BMI values (male:female ratio = 2.2 at BMI <25 kg/m(2), and 1.28 at BMI > or =35 kg/m(2)).


CONCLUSIONS
The association between BP and body weight is at least as strong as that between BP and age and is especially prominent in women.
Sharabi
Yehonatan
Y
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke/NIH, 10 Center Drive, MSC-1620, Building 10, Room 6N252, Bethesda, MD 20892-1620, USA. sharabiy@ninds.nih.gov
Grotto
Itamar
I
Huerta
Michael
M
Grossman
Ehud
E
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D015999:Multivariate Analysis; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D013223:Statistics as Topic; D013599:Systole / Q000502:physiology
D015415:Biomarkers; D001786:Blood Glucose