[Oral itraconazole for treatment of a candida parapsilosis endophthalmitis case].
METHODS
A case of exogenous Candida parapsilosis endophthalmitis was treated first with oral fluconazol and later with intravenous Anfotericin without success. A subsequent therapy using topical fluconazole and oral itraconazole appeared to be effective in controlled the infection.


CONCLUSIONS
Current elective treatment for fungal endophthalmitis is Anfotericine B i.v. An alternative therapy are the azoles. In the reported case itraconazole was used, although its intraocular penetration and effectiveness have not yet been satisfactorily demonstrated. The clinical response in this case leads to the possibility that intraocular oral itraconazole penetration can be sufficient to control infection in cases where the causal fungi is sensitive.
Torres Pérez
J D
JD
Hospital General Yagüe, Complejo Hospitalario de Burgos, España. jesusdtorres@teleline.es
Olea Cascón
J
J
Crespo Ortiz
P
P
Uriarte Estefanía
F
F
Tortajada Goitia
B
B
Pérez-Salvador
J L
JL
D000284:Administration, Oral; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole