Ability of eugenol to reduce tongue edema induced by Dieffenbachia picta Schott in mice.
Dieffenbachia picta Schott (Araceae), known in Brazil as "comigo-ninguém-pode" is an ornamental plant with toxic properties. Its juice, when chewed, causes a painful edema of the oral mucous membranes, buccal ulcerations and tongue hypertrophy. This acute inflammation sometimes becomes severe enough to produce glottis obstruction, respiratory compromise and death. Eugenol (4-alil-2-metoxiphenol), the essential oil extracted from Caryophyllus aromaticus (Myrtaceae) is widely used in odontology. In this study, our objective was to standardize, in mice, a measurable methodology for the tongue edema induced by the topical application of the D. picta stem juice; evaluate the effects of eugenol in this model and compare the results with emergency treatment used in hospitals. Our results show that in spite of a small increase in edema a few minutes after administration, emergency treatment reduced by 70% the overall edema. When compared with the combination of the above drugs, eugenol, even at the smallest dose of 5 microg/kg, regardless of the chosen administration route, or the moment the treatment began, presents better results in the reduction and inhibition of the tongue edema induced by the D. picta juice.
Dip
Etyene Castro
EC
Laboratório de Farmacologia da Inflamação e do Oxido Nítrico, Departamento de Farmacologia Básica e Clínica, ICB, Universidade Federal do Rio de Janeiro, Caixa Postal 68016, 21944-970 Rio de Janeiro, Brazil.
Pereira
Nuno Alvarez
NA
Fernandes
Patricia Dias
PD
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D029064:Araceae; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005054:Eugenol / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000633:toxicity; D010938:Plant Oils / Q000008:administration & dosage / Q000627:therapeutic use; D010947:Plants, Toxic; D027842:Syzygium
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D010938:Plant Oils; D005054:Eugenol