title: Thoracic aortic plaques, transoesophageal echocardiography and coronary artery disease.
abstract: BACKGROUND
  The purpose of this study was to assess whether the detection of atherosclerotic aortic plaques by transoesophageal echocardiography (TEE) could be used as a marker of coronary artery disease (CAD), relying on their number, cross-sectional surface, depth and localisation.
  
  
  METHODS
  The thoracic aortas of 102 consecutive patients (77 men, mean age 67 +/- 12 years) undergoing elective cardiac surgery were assessed by TEE. Atherosclerotic plaques were defined as > or = 5 mm thick focal hyperechogenic zones of the aortic intima and/or lumen irregularities with mobile structures or ulcerations. All patients had undergone prior coronary angiography.
  
  
  RESULTS
  Thoracic aortic plaques were present in 73 patients, 66 of whom had CAD. The presence of aortic plaques detected by TEE identified significant coronary artery disease with a sensitivity of 90% and a specificity of 76%. The maximum transverse cross-sectional plaque area, the maximum plaque depth and the total plaque number all correlated significantly with the presence of CAD, but not with its severity. Multivariate regression analysis showed that aortic plaques, hypertension and hypercholesterolaemia were significant predictors of CAD, but aortic plaques were the most significant predictor regardless of age and sex.
  
  
  CONCLUSIONS
  This study suggests that detection of atherosclerotic aortic plaques is a useful marker of significant coronary artery disease. Absence of plaques in the patients aged over 70 identified a subgroup with a very low probability of CAD.
authors.affiliation: Cardiology Centre and Division, Geneva University Hospital, Geneva, Switzerland. lucka.sekoranja@excite.com
authors.forename: Lucka
authors.initials: L
authors.lastname: Sekoranja
authors.forename: Cédric
authors.initials: C
authors.lastname: Vuille
authors.forename: Francesco
authors.initials: F
authors.lastname: Bianchi-Demicheli
authors.forename: Pierre-André
authors.initials: PA
authors.lastname: Dorsaz
authors.forename: Afksendyios
authors.initials: A
authors.lastname: Kalangos
authors.forename: Pedro T
authors.initials: PT
authors.lastname: Trindade
authors.forename: René
authors.initials: R
authors.lastname: Lerch
mesh_terms: D000368:Aged; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging*; D001018:Aortic Diseases / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D017548:Echocardiography, Transesophageal; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012680:Sensitivity and Specificity