title: Polycythemia vera in a child following treatment for acute lymphoblastic leukemia.
abstract: Polycythemia vera (PV), a hematologic stem cell disorder characterized by predominant erythroid proliferation, is extremely rare in childhood. Some PV patients develop acute leukemia, especially acute myelogenous leukemia, but cases of PV occurring after treatment of acute leukemia are rare. The authors describe a girl with an atrioventricular canal who was diagnosed with acute lymphoblastic leukemia (ALL) at 23 months of age, was cured with chemotherapy, and developed PV 7 years later. She went on to develop hepatic complications of PV that culminated in death from liver disease at 20 years of age, without recurrence of ALL.
authors.affiliation: Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32610-0296, USA.
authors.forename: Nadia D
authors.initials: ND
authors.lastname: Sutherland
authors.forename: Regino
authors.initials: R
authors.lastname: Gonzalez-Peralta
authors.forename: Vonda
authors.initials: V
authors.lastname: Douglas-Nikitin
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hunger
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001856:Bone Marrow Examination; D006502:Budd-Chiari Syndrome / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000150:complications; D011087:Polycythemia Vera / Q000139:chemically induced* / Q000150:complications / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents