title: [A case of Barrett's esophageal carcinoma successfully treated with TS-1 in an elderly patient].
abstract: A 92-year-old man was admitted to the hospital for rehabilitation. Upper gastrointestinal endoscopy was performed 2 weeks after admission because of vomiting which was found to be due to a Barrett's esophageal carcinoma at the lower esophagus. We chose chemotherapy with TS-1 at the dose of 50 mg/day in consideration of his age and performance status. His difficulty in swallowing disappeared rapidly. After 7 days of treatment, grade 3 anorexia appeared, so the dosage of TS-1 was reduced to 25 mg/day. After the reduction of TS-1, anorexia soon disappeared. The regimen consisted of TS-1 every 6 weeks as 1 cycle. After 7 cycles of treatment, upper gastrointestinal endoscopy and upper gastrointestinal series revealed that the tumor had a completely disappeared. The effects of chemotherapy were judged as CR. This case suggests that administration of TS-1 is an effective choice of chemotherapy not only for gastric carcinoma but also Barrett's esophageal carcinoma.
authors.affiliation: Dept. of Surgery, Fujita Health University, School of Medicine.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Imazu
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ochiai
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Komori
authors.forename: Ichiro
authors.initials: I
authors.lastname: Uyama
authors.forename: Toshiki
authors.initials: T
authors.lastname: Matsubara
authors.forename: Shigeru
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Syoji
authors.forename: Ikuo
authors.initials: I
authors.lastname: Yoshida
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Masui
authors.forename: Syuhei
authors.initials: S
authors.lastname: Tonomura
authors.forename: Kichizou
authors.initials: K
authors.lastname: Nagai
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hattori
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001471:Barrett Esophagus / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid