title: Mixed infection with unusual fungi and staphylococcal species in two extremely premature neonates.
abstract: Systemic fungal infections are being recognized with increasing frequency in extremely premature neonates. We report two such infants with late-onset mixed infection with Staphylococcal species and unusual fungi. These cases are of interest in view of recent reports on the interaction of Staphylococcal cell wall components and neutrophils, as damaged skin sites could form a nidus and portal of entry for saprophytic fungal pathogens. It is also important to consider fungal infection as a possibility in sick premature infants with necrotic skin lesions even when the systemic signs have an alternative explanation with ongoing bacteremia.
authors.affiliation: Division of Neonatology, Department of Pediatrics, All Children's Hospital and University of South Florida College of Medicine, St Petersburg/Tampa, FL 33701, USA.
authors.forename: Akhil
authors.initials: A
authors.lastname: Maheshwari
authors.forename: Carine I
authors.initials: CI
authors.lastname: Stromquist
authors.forename: Lourdes
authors.initials: L
authors.lastname: Pereda
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Emmanuel
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003881:Dermatomycoses / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000382:microbiology*; D019102:Infant, Very Low Birth Weight; D008297:Male; D013203:Staphylococcal Infections / Q000150:complications / Q000188:drug therapy; D014250:Trichosporon
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B