title: [Diagnostic value of immuno-hormonal relationships in adolescents in early primary tuberculosis infection].
abstract: The immunological and hormonal links of homeostasis and the pattern of their relationships were studied in 137 adolescents with early primary tuberculous infection (EPTI) and 79 adolescents uninfected with tuberculosis (control). There was a significant increase in the specific functional activity of T lymphocytes and a reduction in their nonspecific functional activity as compared with the controls, as well as an elevation of the levels of thyroxine, cortisol, and insulin. In EPTI, there was an unbalanced enhancement of the activity of cortisol and insulin with the relative deficiency of the latter, which is indicative of overstrain of nonspecific adaptation reactions. In EPTI, integration of immune-hormonal liaison has been established to occur with the radical (90%) change of the body's functional system. Highly reliable two-dimensional indicators have been proposed for the diagnosis of EPTI in adolescents.
authors.forename: I A
authors.initials: IA
authors.lastname: Sirenko
authors.forename: A N
authors.initials: AN
authors.lastname: Zosimov
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007136:Immunoglobulins / Q000276:immunology*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism
chemical_list: D007136:Immunoglobulins; D007328:Insulin; D006854:Hydrocortisone