Cloning of TLR3 isoform.
Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2,520 bp cDNAs compared to the 2,712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is co-expressed with wild type TLR3 in primary human astrocytes and glioblastoma cell lines. This finding suggests the TLR3 isoform in astrocytes may have a different immunological role for binding ligands during the immune response in brain.
Yang
Eunjeong
E
Department of Microbiology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.
Shin
Jeon-Soo
JS
Kim
Hyemi
H
Park
Hyoung Woo
HW
Kim
Myoung Hee
MH
Kim
Se Jong
SJ
Choi
In-Hong
IH
D001253:Astrocytes / Q000502:physiology*; D003001:Cloning, Molecular; D006801:Humans; D007536:Isomerism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics*; D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3; D051193:Toll-Like Receptors