Antiplasmodial agents from the leaves of Glossocalyx brevipes.
A phytochemical study of the methylene chloride/methanol (1/1) extract of the leaves of Glossocalyx brevipes Benth. (Monimiaceae) afforded three new derivatives of homogentisic acid, methyl 2-(1'beta-geranyl-5'beta-hydroxy-2'-oxocyclohex-3'-enyl)acetate (1), 2-(1'beta-geranyl-5'beta-hydroxy-2'-oxocyclohex-3'-enyl)acetic acid (2), methyl 2-(1'beta-geranyl-5'beta-hydroxy-4'beta-methoxy-2'-oxocyclohexyl)acetate (3), and two known alkaloids, aristololactam BII and liriodenine. Compounds 1 and 2 and liriodenine showed modest in vitro activity against Plasmodium falciparum.
Mbah
James A
JA
Chemistry Department, Faculty of Science, University of Dschang, Dschang, Cameroon.
Tane
Pierre
P
Ngadjui
Bonaventure T
BT
Connolly
Joseph D
JD
Okunji
Christopher C
CC
Iwu
Maurice M
MM
Schuster
Brian M
BM
D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D019770:Lauraceae; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects*
D000981:Antiprotozoal Agents; D010936:Plant Extracts