title: Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.
abstract: To investigate the possibility of altered gene expression of growth factors in prenatal growth retardation, we assessed expression of the genes for insulin-like growth factor-I (IGF-I) and epidermal growth factor receptor (EGFR) by RT-PCR from human placentas at term delivery in two groups: appropriate for gestational age (AGA) and pregnancies complicated with IUGR. The placentas from IUGR gestations showed reduced IGF-I expression with a significance of p = 0.008, whereas we did not find any significant differences in EGFR gene expression.
authors.affiliation: Department of Molecular Genetics, University Children's Hospital Miguel Servet, University of Zaragoza, Spain. mtcalvo@salud.aragob.es
authors.forename: M T
authors.initials: MT
authors.lastname: Calvo
authors.forename: A
authors.initials: A
authors.lastname: Romo
authors.forename: J J
authors.initials: JJ
authors.lastname: Gutiérrez
authors.forename: E
authors.initials: E
authors.lastname: Relaño
authors.forename: E
authors.initials: E
authors.lastname: Barrio
authors.forename: A
authors.initials: A
authors.lastname: Ferrández Longás
mesh_terms: D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D015870:Gene Expression; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D010920:Placenta / Q000166:cytology* / Q000502:physiology / Q000503:physiopathology; D011247:Pregnancy; D012337:RNA, Ribosomal, 18S / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D012337:RNA, Ribosomal, 18S; D007334:Insulin-Like Growth Factor I; D066246:ErbB Receptors