title: The surgical effect of callosotomy in the treatment of intractable seizure.
abstract: We evaluated the surgical effects of the callosotomy, particularly with respect to the effect of callosotomy in some seizure types and the extent of surgery. Twenty-one patients with a minimum follow-up of two year were enrolled. The most significant effect of callosotomy was the complete suppression of the generalized seizures associated with drop attack in 12 of 21 patients and seizure reduction of more than 75% in 6 of 21 patients. The surgical effect on the partial seizures was very variable. Transient disconnection syndrome appeared in 4 patients after anterior callosotomy. Total callosotomy by staged operation significantly suppressed generalized seizures associated with drop attack without any disconnection syndrome. Our data show that callosotomy is quite a good approach to the surgical treatment of drop attacks accompanied by disabling generalized seizures.
authors.affiliation: Department of Neurosurgery, Yonsei University College of Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Dong-Seok
authors.initials: DS
authors.lastname: Kim
authors.forename: Kook-Hee
authors.initials: KH
authors.lastname: Yang
authors.forename: Tae-Gon
authors.initials: TG
authors.lastname: Kim
authors.forename: Jong-Hee
authors.initials: JH
authors.lastname: Chang
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Chang
authors.forename: Joong-Uhn
authors.initials: JU
authors.lastname: Choi
authors.forename: Byung-In
authors.initials: BI
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003337:Corpus Callosum / Q000601:surgery*; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D016896:Treatment Outcome