[Amiodarone liver toxicity about two cases and review of literature].
BACKGROUND
Amiodarone can induced hepatic dysfunction.


METHODS
We describe two patients who developed hepatotoxicity presenting suggestive histological features. The outcome was fatal in one case but lesions were reversible in the second case upon treatment interruption.


CONCLUSIONS
These observations show the necessity of hepatic monitoring of patients treated with amiodarone in order to detect potentially severe hepatotoxicity.
Iba-Ba
J
J
BP 2318, Libreville, Gabon. ibabajose@yahoo.fr
Tilea
M
M
Balligand
J-L
JL
Lefebvre
C
C
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000097:blood
D000889:Anti-Arrhythmia Agents; D010743:Phospholipids; D000638:Amiodarone