[Stimulation of the delta 1-receptors help to decrease reperfusion induced myocardial stunning].
In vivo or in vitro administration of a omega 1 receptor agonist d-SKF 10,047 (1 mg/kg intravenously or 10 mg/l in vitro) promoted an increase in the resistance of isolated perfused rat heart to ischemia/reperfusion injury. Both in vivo and in vitro stimulation of omega receptors prevents development of reperfusion contracture and release of creatine kinase and increases the developed pressure, double product, +dP/dt, and -dP/dt in the left ventricle. Activation of omega receptors has no significant effect on the occurrence of reperfusion arrhythmias ex vivo. Stimulation of cardiac sigma receptors is proposed to prevent myocardial stunning.
Maslov
L N
LN
Institute of Cardiology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, ul. Kievskaya 111, Tomsk, 634012 Russia. maslov@cardio.tsu.ru
Lishmanov
Iu B
IuB
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D003402:Creatine Kinase / Q000187:drug effects / Q000378:metabolism; D004562:Electrocardiography; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000188:drug therapy*; D017682:Myocardial Stunning / Q000517:prevention & control*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000187:drug effects*; D016276:Ventricular Function
D017465:Receptors, Opioid, delta; C012134:SK&F 10047; D003402:Creatine Kinase; D010620:Phenazocine