title: Discovery of diarylacrylonitriles as a novel series of small molecule sortase A inhibitors.
abstract: On the basis of a hit from random screening, a novel class of small-molecule sortase A inhibitors was generated. The primary structure-activity relationship and the minimal structural requirements for potency were established through structural modifications and molecular modeling studies.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, 28 Yungun, Jongro, Seoul 110-460, Korea.
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Soo-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Jaekwang
authors.initials: J
authors.lastname: Lee
authors.forename: Won-Jea
authors.initials: WJ
authors.lastname: Cho
authors.forename: Taeho
authors.initials: T
authors.lastname: Lee
authors.forename: Sanghee
authors.initials: S
authors.lastname: Kim
mesh_terms: D000181:Acrylonitrile / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D019881:Aminoacyltransferases / Q000037:antagonists & inhibitors*; D001426:Bacterial Proteins; D003546:Cysteine Endopeptidases; D007700:Kinetics; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D019881:Aminoacyltransferases; C120542:sortase A; D003546:Cysteine Endopeptidases; D000181:Acrylonitrile