title: Mycophenolate mofetil in pregnancy after renal transplantation: a case of major fetal malformations.
abstract: BACKGROUND
  Mycophenolate mofetil has teratogenic properties in rats and rabbits. Previous human studies have reported an increased rate of fetal losses with its use. We report a case of major fetal malformations due to mycophenolate mofetil.
  
  
  METHODS
  The patient was treated with mycophenolate mofetil before conception and during the first trimester of pregnancy. The fetus had multiple malformations, specifically, facial dysmorphology and midline anomalies, including agenesis of the corpus callosum.
  
  
  CONCLUSIONS
  This case of fetal malformation attributable to mycophenolate mofetil must be taken into consideration when considering pregnancy in an organ-transplant recipient.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Antoine Béclère, Clamart, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Le Ray
authors.forename: Aurore
authors.initials: A
authors.lastname: Coulomb
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Elefant
authors.forename: Rene
authors.initials: R
authors.lastname: Frydman
authors.forename: François
authors.initials: F
authors.lastname: Audibert
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000328:Adult; D000818:Animals; D005260:Female; D005333:Fetus / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016030:Kidney Transplantation; D009173:Mycophenolic Acid / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011247:Pregnancy
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid