Protein kinase C family functions in B-cell activation.
Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCbeta is indispensable for B-cell antigen receptor (BCR)-induced NF-kappaB activation and B-cell survival. Recent evidence indicates that PKCbeta might regulate inhibitor of kappaB kinase (IKK) and NF-kappaB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCdelta is specifically required to maintain the tolerance of self-reactive B cells.
Guo
Beichu
B
Department of Immunology, University of Washington School of Medicine, Seattle 98195, USA.
Su
Thomas T
TT
Rawlings
David J
DJ
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002470:Cell Survival / Q000276:immunology*; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D021962:Membrane Microdomains / Q000276:immunology; D051379:Mice; D011493:Protein Kinase C / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell; D011493:Protein Kinase C