title: Immunosuppressive auronol glycosides from Artocarpus tonkinensis.
abstract: Activity-guided fractionation of the n-butanol extract from the leaves of Artocarpus tonkinensis led to the isolation of the auronol glycosides maesopsin 4-O-glucoside (1), as well as the new alphitonin-4-O-glucoside (2). These structures were identified on the basis of MS and NMR spectroscopic data. The lymphocyte stimulation test showed both compounds having immunosuppressive activity.
authors.affiliation: Institute of Chemistry, National Center for Natural Science and Technology, Cau Giay, Hanoi, Vietnam.
authors.forename: T T
authors.initials: TT
authors.lastname: Thuy
authors.forename: C
authors.initials: C
authors.lastname: Kamperdick
authors.forename: P T
authors.initials: PT
authors.lastname: Ninh
authors.forename: T P
authors.initials: TP
authors.lastname: Lien
authors.forename: T T P
authors.initials: TT
authors.lastname: Thao
authors.forename: T V
authors.initials: TV
authors.lastname: Sung
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001572:Benzofurans; D005960:Glucosides; D006027:Glycosides; D007166:Immunosuppressive Agents; D007202:Indicators and Reagents; D010936:Plant Extracts; C485327:maesopsin 4-O-glucoside; D016572:Cyclosporine; D002392:Catechin