title: Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors.
abstract: Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm among American males and is the second leading cause of cancer-related death. Prostate specific antigen screening has resulted in earlier disease detection, yet approximately 30% of men will die of metastatic disease. Slow disease progression, an aging population and associated morbidity and mortality underscore the need for improved disease classification and therapies. To address these issues, we analyzed a cohort of patients using array comparative genomic hybridization (aCGH). The cohort comprises 64 patients, half of whom recurred postoperatively. Analysis of the aCGH profiles revealed numerous recurrent genomic copy number aberrations. Specific loss at 8p23.2 was associated with advanced stage disease, and gain at 11q13.1 was found to be predictive of postoperative recurrence independent of stage and grade. Moreover, comparison with an independent set of metastases revealed approximately 40 candidate markers associated with metastatic potential. Copy number aberrations at these loci may define metastatic genotypes.
authors.affiliation: Comprehensive Cancer Center, University of California at San Francisco, 94115, USA.
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Paris
authors.forename: Armann
authors.initials: A
authors.lastname: Andaya
authors.forename: Jane
authors.initials: J
authors.lastname: Fridlyand
authors.forename: Ajay N
authors.initials: AN
authors.lastname: Jain
authors.forename: Vivian
authors.initials: V
authors.lastname: Weinberg
authors.forename: David
authors.initials: D
authors.lastname: Kowbel
authors.forename: John H
authors.initials: JH
authors.lastname: Brebner
authors.forename: Jeff
authors.initials: J
authors.lastname: Simko
authors.forename: J E Vivienne
authors.initials: JE
authors.lastname: Watson
authors.forename: Stas
authors.initials: S
authors.lastname: Volik
authors.forename: Donna G
authors.initials: DG
authors.lastname: Albertson
authors.forename: Daniel
authors.initials: D
authors.lastname: Pinkel
authors.forename: Janneke C
authors.initials: JC
authors.lastname: Alers
authors.forename: Theodorus H
authors.initials: TH
authors.lastname: van der Kwast
authors.forename: Kees J
authors.initials: KJ
authors.lastname: Vissers
authors.forename: Fritz H
authors.initials: FH
authors.lastname: Schroder
authors.forename: Mark F
authors.initials: MF
authors.lastname: Wildhagen
authors.forename: Phillip G
authors.initials: PG
authors.lastname: Febbo
authors.forename: Arul M
authors.initials: AM
authors.lastname: Chinnaiyan
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Pienta
authors.forename: Peter R
authors.initials: PR
authors.lastname: Carroll
authors.forename: Mark A
authors.initials: MA
authors.lastname: Rubin
authors.forename: Colin
authors.initials: C
authors.lastname: Collins
authors.forename: Herman
authors.initials: H
authors.lastname: van Dekken
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D015331:Cohort Studies; D018628:Gene Dosage; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006801:Humans; D008297:Male; D046228:Microarray Analysis; D009362:Neoplasm Metastasis / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011237:Predictive Value of Tests; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality; D012008:Recurrence
chemical_list: D014408:Biomarkers, Tumor