title: Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia.
abstract: Three new cyclostellettamines, cyclostellettamine G (1), dehydrocyclostellettamines D (2), and E (3), were isolated together with the known cyclostellettamine A (4) from a marine sponge of the genus Xestospongia as histone deacetylase inhibitors. Their structures were determined by spectral and chemical methods. They inhibit histone deacetylase derived from K562 human leukemia cells with IC(50) values ranging from 17 to 80 microM.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Oku
authors.forename: Koji
authors.initials: K
authors.lastname: Nagai
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shindoh
authors.forename: Yoh
authors.initials: Y
authors.lastname: Terada
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D011726:Pyridinium Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D047131:Xestospongia / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D011726:Pyridinium Compounds; C494038:cyclostellettamine G; C494037:dehydrocyclostellettamine D; C494036:dehydrocyclostellettamine E