title: Matrilysin (matrix metalloproteinase-7): a new promising drug target in cancer and inflammation?
abstract: Matrilysin or MMP-7, one of the smallest of all known matrix metalloproteinases (MMPs), has been studied extensively in many different tumor types, since its discovery more than 20 years ago. However, research during the past several years has revealed that this protease also plays an essential role in innate immunity, and, more particularly, in inflammatory disorders.
authors.affiliation: Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, Ghent (Zwijnaarde), Belgium.
authors.forename: Ben
authors.initials: B
authors.lastname: Wielockx
authors.forename: Claude
authors.initials: C
authors.lastname: Libert
authors.forename: Carole
authors.initials: C
authors.lastname: Wilson
mesh_terms: D000818:Animals; D015195:Drug Design; D004847:Epithelial Cells / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000201:enzymology* / Q000209:etiology; D008168:Lung / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D020783:Matrix Metalloproteinase 7 / Q000276:immunology / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D009369:Neoplasms / Q000201:enzymology* / Q000209:etiology; D014945:Wound Healing / Q000276:immunology / Q000502:physiology
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D020783:Matrix Metalloproteinase 7