title: Treatment of urinary incontinence with anticholinergics in patients taking cholinesterase inhibitors for dementia.
abstract: Clinicians often encounter patients with dementia and urge incontinence who might benefit from both an anticholinergic medication and a cholinesterase inhibitor. At first glance, this combination would seem to violate basic principles of geriatric pharmacology, as the drugs appear to be working at cross-purposes and anticholinergic medications are notorious for worsening cognitive function in susceptible patients. A case is presented and discussed in which this combination was clinically effective and pharmacologically sound.
authors.affiliation: Division of Geriatrics and Gerontology, Department of Pharmacology, Weill Medical College of Cornell University,New York, NY 10021, USA. els2006@med.cornell.edu
authors.forename: Eugenia L
authors.initials: EL
authors.lastname: Siegler
authors.forename: Marcus
authors.initials: M
authors.lastname: Reidenberg
mesh_terms: D000368:Aged; D001559:Benzhydryl Compounds / Q000008:administration & dosage*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage*; D003408:Cresols / Q000008:administration & dosage*; D003704:Dementia / Q000150:complications / Q000188:drug therapy*; D000077265:Donepezil; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007189:Indans / Q000008:administration & dosage*; D018727:Muscarinic Antagonists / Q000008:administration & dosage*; D010665:Phenylpropanolamine; D010880:Piperidines / Q000008:administration & dosage*; D000068737:Tolterodine Tartrate; D014549:Urinary Incontinence / Q000150:complications / Q000188:drug therapy*
chemical_list: D001559:Benzhydryl Compounds; D002800:Cholinesterase Inhibitors; D003408:Cresols; D007189:Indans; D018727:Muscarinic Antagonists; D010880:Piperidines; D010665:Phenylpropanolamine; D000068737:Tolterodine Tartrate; D000077265:Donepezil