IL-9 in allergic inflammation.
Th2 type cytokines such as interleukin (IL)-4, IL-5, IL-9, and IL-13 are important mediators in allergic inflammation. The present review will focus on the role of IL-9 in allergic inflammation. The structure and genomic architecture of IL-9 and its receptor, the source of IL-9 and its regulation as well as its effects on different cell types will be reviewed. Furthermore, the specific role of IL-9 in allergic diseases and the potential therapeutic approach of blocking IL-9 will be discussed.
Hauber
Hans-Peter
HP
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Bergeron
Celine
C
Hamid
Qutayba
Q
D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism / Q000503:physiopathology; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000378:metabolism; D016906:Interleukin-9 / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D018123:Receptors, Interleukin / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D018836:Inflammation Mediators; D016906:Interleukin-9; D018123:Receptors, Interleukin