Guardian at the gate: preventing unspliced pre-mRNA export.
The production of a mature mRNA requires the assembly and cooperation of numerous complexes before nuclear export. The deleterious effects of intron-containing pre-mRNA leakage into the cytoplasm necessitate mechanisms to prevent premature export of partially processed or unprocessed messages. A new study demonstrates that the Saccharomyces cerevisiae protein Mlp1 specifically retains intron-containing pre-mRNAs in the nucleus.
Casolari
Jason M
JM
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA.
Silver
Pamela A
PA
D002148:Calmodulin-Binding Proteins; D006801:Humans; D007438:Introns / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008840:Microfilament Proteins; D022022:Nuclear Pore / Q000378:metabolism; D009687:Nuclear Proteins; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism*; D012326:RNA Splicing; D034443:RNA Transport; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins
D002148:Calmodulin-Binding Proteins; C070177:MARCKSL1 protein, human; C080988:MLP1 protein, S cerevisiae; D008565:Membrane Proteins; D008840:Microfilament Proteins; D009687:Nuclear Proteins; D012322:RNA Precursors; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins