title: GeneWise and Genomewise.
abstract: We present two algorithms in this paper: GeneWise, which predicts gene structure using similar protein sequences, and Genomewise, which provides a gene structure final parse across cDNA- and EST-defined spliced structure. Both algorithms are heavily used by the Ensembl annotation system. The GeneWise algorithm was developed from a principled combination of hidden Markov models (HMMs). Both algorithms are highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.
authors.affiliation: The European Bioinformatics Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. birney@ebi.ac.uk
authors.forename: Ewan
authors.initials: E
authors.lastname: Birney
authors.forename: Michele
authors.initials: M
authors.lastname: Clamp
authors.forename: Richard
authors.initials: R
authors.lastname: Durbin
mesh_terms: D024509:3' Flanking Region; D024506:5' Flanking Region; D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D018076:DNA, Complementary; D008962:Models, Theoretical; D011237:Predictive Value of Tests; D012107:Research Design; D012984:Software
chemical_list: D018076:DNA, Complementary