Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: In vitro studies.
Sex steroids play an important role in modulating pulsatile growth hormone (GH) release, acting at both hypothalamic and pituitary level in both humans and experimental animals. Selective estrogen receptor modulators (SERMs) act as either estrogen receptor agonists or antagonists in a tissue-selective manner. In postmenopausal women, serum GH levels correlate positively with endogenous estradiol levels and insulin-like grwoth factor-I (IGF-I) is positively related to bone mineral density (BMD) at the spine and hip. The aim of the present study was to evaluate, for the first time, the direct effect of LY117018, an analog of raloxifene, on GH secretion from both human and rodent pituitary cells in vitro. Our results demonstrated that pharmacological concentrations of the raloxifene analog LY117018 can stimulate GH secretion through a direct action on the pituitary. LY117018 also showed an estrogen-like activity, inducing the proliferation of rat pituitary GH-secreting adenomatous cells (GH1).
Tulipano
G
G
Endocrine Section, Department of Intternal Medicine, University of Brescia, Brescia, Italy.
Bonfanti
C
C
Poiesi
C
C
Burattin
A
A
Turazzi
S
S
Barone
G
G
Cozzi
R
R
Bollati
A
A
Valle
D
D
Giustina
A
A
D000236:Adenoma / Q000378:metabolism; D000328:Adult; D000368:Aged; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000166:cytology; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D020849:Raloxifene Hydrochloride / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012636:Secretory Rate / Q000187:drug effects; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*; D013629:Tamoxifen / Q000494:pharmacology; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology*
D011759:Pyrrolidines; D020845:Selective Estrogen Receptor Modulators; D013876:Thiophenes; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride; D004958:Estradiol; C025430:LY 117018; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone