title: The prevalence of anti-rubella antibodies in women of childbearing age in Poland.
abstract: Congenital rubella is a clinically serious problem, which is due to maternal infection with rubella virus during the first trimester of pregnancy. It may result in spontaneous abortion or in fetal infection leading to fetal birth defect. Maternal anti-rubella antibodies have a protective effect and they may prevent congenital rubella. Vaccination of 13-year-old girls in Poland was introduced in 1989. Vaccination coverage is above 95%. The presence of anti-rubella antibodies in maternal blood >15 IU/ml is indicative for immunity to rubella. Thus, the aim of the study was the evaluation of anti-rubella antibody levels in women 15-30 years old. Samples of that sera were collected from six provinces in Poland. We have observed the decrease of anti-rubella antibody titer together with increasing age of tested women. Among 1289 investigated women 135 [10.5%] did not have protective levels of anti-rubella antibodies. We have noticed large decline in protective anti-rubella antibodies in young women (19-22 years of age), who are just entering their prime childbearing years.
authors.affiliation: Department of Sera and Vaccines Evaluation, National Institute of Hygiene, Chocimska Street 24, 00-791 Warsaw, Poland. twysokinska@pzh.gov.pl
authors.forename: T
authors.initials: T
authors.lastname: Wysokiñska
authors.forename: W
authors.initials: W
authors.lastname: Janaszek
authors.forename: B
authors.initials: B
authors.lastname: Bucholc
authors.forename: P
authors.initials: P
authors.lastname: Gorska
authors.forename: G
authors.initials: G
authors.lastname: Gniadek
authors.forename: J
authors.initials: J
authors.lastname: Slusarczyk
authors.forename: M
authors.initials: M
authors.lastname: Rawicz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012409:Rubella / Q000453:epidemiology* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G