Cell biological basis for combination radiotherapy using heavy-ion beams and high-energy X-rays.
We investigated the biological effect of combining carbon-beam and X-ray in vitro. The results showed that when we employed Gray equivalent as the indication of therapeutic dose, the effects could be explained with simple additive way in the treatment plan. This fact provides important information about the combined therapy of carbon-beam and X-ray.
Demizu
Yusuke
Y
Division of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
Kagawa
Kazufumi
K
Ejima
Yasuo
Y
Nishimura
Hideki
H
Sasaki
Ryohei
R
Soejima
Toshinori
T
Yanou
Toshihiro
T
Shimizu
Masakazu
M
Furusawa
Yoshiya
Y
Hishikawa
Yoshio
Y
Sugimura
Kazuro
K
D017209:Apoptosis / Q000528:radiation effects*; D002244:Carbon; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018499:Linear Energy Transfer / Q000528:radiation effects*; D011829:Radiation Dosage; D011882:Radiotherapy, High-Energy / Q000379:methods*; D012016:Reference Values; D012062:Relative Biological Effectiveness; D012468:Salivary Gland Neoplasms / Q000473:pathology; D012680:Sensitivity and Specificity
D002244:Carbon