CARDINAL roles in apoptosis and NFkappaB activation.
Numerous proteins containing the caspase recruitment domain (CARD) have now been identified. While certain CARD-containing proteins are involved in caspase activation in the context of apoptosis, many others participate in NFkappaB signaling pathways associated with innate or adaptive immune responses. Here, we discuss the CARD-containing proteins that have been implicated as participants in immune response signaling pathways that culminate in NFkappaB activation.
Bouchier-Hayes
Lisa
L
Division of Cellular Immunology, La Jolla Institute for Allergy and Immunology San Diego, California 92121, USA.
Martin
Seamus J
SJ
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D017209:Apoptosis; D053468:CARD Signaling Adaptor Proteins; D002352:Carrier Proteins / Q000502:physiology*; D020170:Caspase 1 / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D016328:NF-kappa B / Q000502:physiology*; D009363:Neoplasm Proteins / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D053468:CARD Signaling Adaptor Proteins; C455623:CARD8 protein, human; D002352:Carrier Proteins; D016328:NF-kappa B; D009363:Neoplasm Proteins; D020170:Caspase 1