title: Structure-activity relationship of coordinated catecholamine in the [Ru(III)(NH3)4(catecholamine)]+ complex.
abstract: The redox chemistry and pharmacological studies of the novel blue ruthenium(III)-catecholamine complexes were investigated in aqueous medium and compared to the free catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ can be oxidized or reduced reversibly in one electron redox couples in aqueous solution. This is in contrast to the free catecholamines, which has a complicated electrochemical behavior due to coupled protonation process. The introduction of the ruthenium group reduces the intrinsic efficacy of the studied catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ complex aqueous medium is more stable than the free catecholamines ligand in the same conditions.
authors.affiliation: Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto-USP, Av. dos Bandeirantes, 3900, 14040-901 Ribeirão Preto, São Paulo, Brazil.
authors.forename: Renata Galvão
authors.initials: RG
authors.lastname: de Lima
authors.forename: Mario Sérgio Pereira
authors.initials: MS
authors.lastname: Marchesi
authors.forename: Márcio Augusto Fressatto
authors.initials: MA
authors.lastname: de Godoy
authors.forename: Adriano Oliano
authors.initials: AO
authors.lastname: Cassano
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: de Oliveira
authors.forename: Roberto Santana
authors.initials: RS
authors.lastname: da Silva
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000737:chemistry* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D009942:Organometallic Compounds; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D002395:Catecholamines; D009942:Organometallic Compounds; C486938:Ru(III)(NH3)4(catecholamine); D017975:Ruthenium Compounds