Aldosterone and cardiovascular remodelling: focus on myocardial failure.
Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.
Shieh
Frederick K
FK
Boston University Medical School, Boston University Medical Center, Boston, Massechussetts, USA.
Kotlyar
Eugene
E
Sam
Flora
F
D000450:Aldosterone / Q000378:metabolism*; D000818:Animals; D001808:Blood Vessels / Q000503:physiopathology; D002303:Cardiac Output, Low / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology*; D002319:Cardiovascular System / Q000503:physiopathology*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics; D006801:Humans; D018384:Oxidative Stress; D011110:Polymorphism, Genetic; D020257:Ventricular Remodeling
D000450:Aldosterone; D019405:Cytochrome P-450 CYP11B2