Chronic excretion of a norovirus in a child with cartilage hair hypoplasia (CHH).
We have demonstrated the long-term excretion of a stable recombinant norovirus in a patient with cartilage hair hypoplasia (CHH), with a T cell immunodeficiency, following bone marrow transplantation (BMT). The patient excreted an ARG320/1999/US-like recombinant norovirus (rGII-3) for 156 days during a period of immune reconstitution. The child was symptomatic during the period of virus shedding. It is not known if the child acquired the recombinant strain or if recombination occurred in vivo.
Gallimore
Chris I
CI
Central Public Health Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London, UK. christopher.gallimore@hpa.org.uk
Lewis
David
D
Taylor
Clive
C
Cant
Andrew
A
Gennery
Andrew
A
Gray
Jim J
JJ
D000015:Abnormalities, Multiple / Q000821:virology*; D000595:Amino Acid Sequence; D001483:Base Sequence; D002356:Cartilage / Q000002:abnormalities*; D004392:Dwarfism; D006197:Hair / Q000002:abnormalities*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000821:virology*; D007223:Infant; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010009:Osteochondrodysplasias; D010802:Phylogeny; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid