Targeted peripheral analgesics therapy for neuropathic pain.
The term targeted peripheral analgesics has been suggested to describe analgesics with a mechanism of action that appears to be primarily through reducing pain transmission within the peripheral nervous system. Key differences between targeted peripheral (topical) and systemic analgesics and the difference between topical and transdermal analgesics are discussed in this article. A review of the clinical conditions, which have been reported to respond to targeted peripheral analgesics, also is described in detail.
Argoff
Charles E
CE
North Shore University Hospital/NYU School of Medicine, Cohn Pain Management Center, 4300 Hempstead Turnpike, Bethpage, NY 11714, USA. pargoff@optonline.net
D000279:Administration, Cutaneous; D000287:Administration, Topical; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005157:Facial Pain / Q000188:drug therapy; D006801:Humans; D017116:Low Back Pain / Q000188:drug therapy; D009437:Neuralgia / Q000188:drug therapy*; D017933:Peripheral Nervous System / Q000187:drug effects*
D000700:Analgesics