title: Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.
abstract: A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKA(y) mice in vivo. On the basis of their biological activities, 5-(4-[2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy]benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.
authors.affiliation: New Drug Research Laboratories, Chong Kun Dang Research Institute, Cheonan P.O. Box 74, Cheonan 330-831, South Korea.
authors.forename: Bok Young
authors.initials: BY
authors.lastname: Kim
authors.forename: Joong Bok
authors.initials: JB
authors.lastname: Ahn
authors.forename: Hong Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Sung Kwon
authors.initials: SK
authors.lastname: Kang
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Jae Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Soon Kil
authors.initials: SK
authors.lastname: Ahn
authors.forename: Chung Il
authors.initials: CI
authors.lastname: Hong
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Yoon
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D015195:Drug Design; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D051379:Mice; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D045162:Thiazolidinediones / Q000737:chemistry*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D011687:Purines; D011725:Pyridines; D045162:Thiazolidinediones; D014280:Triglycerides; C089946:2,4-thiazolidinedione