title: Myocardial perfusion measurements by spin-labeling under different vasodynamic states.
abstract: In this study absolute myocardial perfusion was determined using a spin-labeling magnetic resonance imaging (MRI) technique at 2 Tesla. The technique was applied to 16 healthy volunteers at resting conditions, adenosine-induced stress, and oxygen breathing. Overall myocardial quantitative perfusion was determined as 2.3 +/- 0.8 mL/g/min (rest), 4.2 +/- 1.0 mL/g/min (adenosine), and 1.6 +/- 0.6 mL/g/min (oxygen), respectively. T1 of left ventricular blood pool decreased from 1709 +/- 101 ms (rest) to 1423 +/- 61 ms (oxygen), whereas T1 of right ventricular blood did not change significantly (1586 +/- 126 ms and 1558 +/- 150 ms). In conclusion, the presented technique for quantification of myocardial perfusion is an alternative to contrast agent-based methods. The spin labeling method is noninvasive and easily repeatable and it could therefore become an important tool to study changes in myocardial perfusion under different vasodynamic states.
authors.affiliation: Department of Biophysics (EP5), University of Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Fidler
authors.forename: Christian M
authors.initials: CM
authors.lastname: Wacker
authors.forename: Christian
authors.initials: C
authors.lastname: Dueren
authors.forename: Matthias
authors.initials: M
authors.lastname: Weigel
authors.forename: Peter M
authors.initials: PM
authors.lastname: Jakob
authors.forename: Wolfgang R
authors.initials: WR
authors.lastname: Bauer
authors.forename: Axel
authors.initials: A
authors.lastname: Haase
mesh_terms: D000241:Adenosine; D000328:Adult; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008955:Models, Cardiovascular; D009206:Myocardium / Q000473:pathology*; D010100:Oxygen / Q000008:administration & dosage; D012146:Rest; D013113:Spin Labels; D014665:Vasodilator Agents; D016276:Ventricular Function
chemical_list: D013113:Spin Labels; D014665:Vasodilator Agents; D000241:Adenosine; D010100:Oxygen