[Isolation and identification of the ligustilide compounds from the root of Angelica sinensis].
OBJECTIVE
To find out substance basis of pharmacological activities of Angelica sinensis.


METHODS
Chromatographic methods were used to isolate the chemical components, and spectroscopic methods were used to identify their structures.


RESULTS
Five compounds were isolated from the ethanol extract of the roots of Angelica sinensis. Their structures were identified as: (Z)-ligustilide, (Z)-6,7-epoxyligustilide, (Z)-6,7-cis-dihydroxyligustilide, (E)-6,7-cis-dihydroxy-ligustilide and 11-angeloylsenkyunolide F.


CONCLUSIONS
11-angeloylsenkyunolide F was obtained from Angelica sinensis for the first time.
Lu
Xin-hua
XH
New Drug Research and Development Center, North China Pharmaceutical Corporation, Shijiazhuang 050015, Hebei, China.
Liang
Hong
H
Zhao
Yu-ying
YY
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D029971:Angelica sinensis / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
C488006:11-angeloylsenkyunolide F; D001572:Benzofurans; C027820:ligustilide; D015107:4-Butyrolactone