2-tert-butyl-3-methyl-2,3-dihydroimidazol- 4-one-N-oxide: a new nitrone-based chiral glycine equivalent.
Cycloaddition reactions between a new homochiral imidazolone-derived nitrone afford cycloadducts in high yield and with high stereoselectivity. Subsequent cycloadduct elaboration affords the gamma-lactones of gamma-hydroxy-alpha-amino acids as well as the optically pure amino acids themselves.
Baldwin
Steven W
SW
Paul M. Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346, USA. steven.baldwin@duke.edu
Long
Alan
A