title: Hetero: a program to simulate the evolution of DNA on a four-taxon tree.
abstract: We present a computer program to simulate the evolution of a nucleotide sequence on a phylogenetic tree with four tips. The program, Hetero, allows users to assign lineage-specific differences in the rate matrices used to describe the evolutionary process. It has a simple user interface and output, making it equally useful in the teaching and research of phylogenetics.
authors.affiliation: School of Biological Sciences, University of Sydney, NSW, Australia. lsj@bio.usyd.edu.au
authors.forename: Lars S
authors.initials: LS
authors.lastname: Jermiin
authors.forename: Simon Y W
authors.initials: SY
authors.lastname: Ho
authors.forename: Faisal
authors.initials: F
authors.lastname: Ababneh
authors.forename: John
authors.initials: J
authors.lastname: Robinson
authors.forename: Anthony W D
authors.initials: AW
authors.lastname: Larkum
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D004252:DNA Mutational Analysis / Q000379:methods*; D019143:Evolution, Molecular; D020869:Gene Expression Profiling / Q000379:methods*; D014644:Genetic Variation; D008957:Models, Genetic; D015233:Models, Statistical; D008967:Molecular Biology / Q000193:education; D009010:Monte Carlo Method; D010802:Phylogeny; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D013663:Teaching / Q000379:methods