Preventive effect of the flavonoid, wogonin, against ethanol-induced gastric mucosal damage in rats.
Whether wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have antiinflammatory and antitumor activities in various cell types, possesses a gastric cytoprotective effect was investigated in an ethanol-induced gastric damage model in rats. Ethanol administration alone induced evident gastric damage including gastric hemorrhages and edema, while this gastric damage was significantly attenuated by wogonin pretreatment (30 mg/kg B.W.) 1 hr before ethanol administration. As major protective mechanisms of wogonin on ethanol-induced gastric damage, we found that wogonin showed either antiinflammatory effects through dual actions on arachidonic acid metabolism, i.e., induction of prostaglandin D2 and suppression of 5S-hydroxyeicosatetraenoic acid (5S-HETE), or preventive induction of profuse apoptosis in the stomach. Conclusively, the flavonoid wogonin could be used as a preventive agent of alcohol-induced gastropathy, whose actions were proven to be strong antiinflammation and apoptosis induction.
Park
Soojin
S
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Seoul, Korea.
Hahm
Ki-Baik
KB
Oh
Tae-Young
TY
Jin
Joo-Hyun
JH
Choue
Ryowon
R
D000409:Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D017209:Apoptosis; D016718:Arachidonic Acid / Q000378:metabolism; D051546:Cyclooxygenase 2; D019610:Cytoprotection; D004365:Drugs, Chinese Herbal; D000431:Ethanol / Q000009:adverse effects; D044950:Flavanones / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005756:Gastritis / Q000139:chemically induced* / Q000517:prevention & control*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D015363:Quinolones / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D000897:Anti-Ulcer Agents; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D018840:HSP70 Heat-Shock Proteins; D006893:Hydroxyeicosatetraenoic Acids; D007527:Isoenzymes; D015363:Quinolones; D016718:Arachidonic Acid; D000431:Ethanol; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C052785:rebamipide; D000409:Alanine; C085514:wogonin