title: [Effect of Cryptoporus volvatus (Peck) Schear on leukotriene production from polymorphonuclear leukocytes in rats].
abstract: OBJECTIVE
  To study action of Cryptoporus volvatus ferment substance (CVFS) on leukotriene production of polymorphonuclear leukocytes in rats.
  
  
  METHODS
  The level of slow reaction substance (SRS) and leukotriene B4 (LTB4) in polymorphonuclear leukocytes (PMNs) in rats in vitro were determined with bioassay and HPLC.
  
  
  RESULTS
  CVFS 0.9, 2.7 g.kg-1 by ig significantly inhibited SRS and LTB4 production in PMNs in rats in vivo.
  
  
  CONCLUSIONS
  The inhibition effect of CVFS on SRS and LTB4 release may be related to its mechanism of anti-inflammation and anti-asthma.
authors.affiliation: Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical College of Zhejiang University, Medical College of Hangzhou Normal University, Hangzhou, Zhejiang, China.
authors.forename: Sai-hong
authors.initials: SH
authors.lastname: Jin
authors.forename: Qiang-min
authors.initials: QM
authors.lastname: Xie
authors.forename: Xiao-xia
authors.initials: XX
authors.lastname: Lin
authors.forename: Yang-mei
authors.initials: YM
authors.lastname: Deng
authors.forename: Ji-qiang
authors.initials: JQ
authors.lastname: Chen
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002469:Cell Separation; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007975:Leukotriene B4 / Q000378:metabolism*; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D011124:Polyporaceae / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013189:SRS-A / Q000378:metabolism
chemical_list: D018927:Anti-Asthmatic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D013189:SRS-A; D007975:Leukotriene B4