title: Frequency of anticardiolipin, antinuclear and anti beta2GP1 antibodies is not increased in unselected epileptic patients: a case-control study.
abstract: In order to determine whether auto antibodies were restricted to some subtypes of epilepsy, we included 81 unselected epileptic patients and 81 controls, studied clinical data, EEG, neuroimaging, measured antinuclear (ANA), anticardiolipin (aCL) and beta2GP1 antibodies.
  
  
  RESULTS
  Epilepsy was active in 74 patients, generalised in 78 and partial in 9. Auto antibodies were positive at the same frequency and the same level among patients and controls (ANA+ 17% vs. 11%; aCL+ 4% vs. 7%; beta2GP1 antibodies+ 5% vs. 6%). There was no increased frequency of auto antibodies among subgroups of epileptic patients except ANA which were more frequent when patients had more than 10 seizures per year.
  
  
  CONCLUSIONS
  Positivity of ANA, aCL and beta2GP1 antibodies is not increased in all types of epilepsy and further studies are needed to determine exactly which kind of seizure is immune-mediated.
authors.affiliation: Department of Internal Medicine, Desgenettes Hospital, 108 Boulevard Pinel, 69 003 Lyon, France. philippe.debourdeau@waika9.com
authors.forename: Philippe
authors.initials: P
authors.lastname: Debourdeau
authors.forename: Patrick
authors.initials: P
authors.lastname: Gérome
authors.forename: Christine
authors.initials: C
authors.lastname: Zammit
authors.forename: Anne
authors.initials: A
authors.lastname: Saillol
authors.forename: Marc
authors.initials: M
authors.lastname: Aletti
authors.forename: Laurent
authors.initials: L
authors.lastname: Bargues
authors.forename: François
authors.initials: F
authors.lastname: Cointet
mesh_terms: D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D017153:Antibodies, Anticardiolipin / Q000276:immunology*; D000974:Antibodies, Antinuclear / Q000276:immunology*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004827:Epilepsy / Q000453:epidemiology / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D008297:Male; D015995:Prevalence; D053482:beta 2-Glycoprotein I
chemical_list: D000888:Antibodies, Anti-Idiotypic; D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I