Pure red cell aplasia after ABO major-mismatched allogeneic peripheral blood stem cell transplantation successfully treated with plasma exchange and low-dose steroid: two case reports.
Pure red cell aplasia (PRCA) is a complication of ABO-incompatible allogeneic stem cell transplantation. The mechanism is not well known, although the isoagglutinin titer before transplantation or cyclosporine use is considered to be the cause. Patients with this complication require more blood transfusions than those without it. There is no standard treatment. We report two cases of PRCA after allogeneic peripheral blood stem cell transplantation that were successfully treated with plasma exchange and low-dose steroid.
Tsai
Hui-Jen
HJ
Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Lin
Sheng-Fung
SF
Liu
Ta-Chih
TC
Chang
Chao-Sung
CS
Hsiao
Hui-Hua
HH
Chen
Tyen-Po
TP
D000017:ABO Blood-Group System / Q000276:immunology*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D001787:Blood Group Incompatibility / Q000150:complications*; D006801:Humans; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D010951:Plasma Exchange; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000628:therapy; D014184:Transplantation, Homologous
D000017:ABO Blood-Group System; D000305:Adrenal Cortex Hormones