New start and finish for complex polyketide biosynthesis.
The polyketide vicenistatin has significant anticancer activity. In the January issue of Chemistry & Biology, Kakinuma and coworkers reported on the vicenistatin biosynthetic gene cluster and demonstrated in vitro glycosylation of its aglycone core, raising the possibility of producing analogs with altered sugar residues.
Caffrey
Patrick
P
Department of Industrial Microbiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
D000617:Aminoglycosides / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*
D000617:Aminoglycosides; D000970:Antineoplastic Agents; D007769:Lactams; D018942:Macrolides; C082785:vicenistatin