title: [Protective effect of qi dong yi xin on acute myocardial infarction in dogs].
abstract: OBJECTIVE
  To observe the protective effects on acute myocardial infarction of QDYX in dog.
  
  
  METHODS
  The corconary ciculation and cardial oxygen metabolism, the degree and range of myocardial ischemia, myocardial infarct size, and the changes of the enzymes in serum were determined by using the acute myocardial infarction model of ligation of LAD in the anaesthetized open-chest dogs.
  
  
  RESULTS
  The coronary resistance and cardial oxygen consumption were decreased and the myocardial blood flow was increased in dogs treated with QDYX of 1.0,2.0 mg.kg-1. The degree and range of myocardial ischemia, myocardial infarct size and the activity of serum CK, LDH were decreased in acute myocardial infarcion dogs treated with QDYX of 1.0,2.0 mg.kg-1.
  
  
  CONCLUSIONS
  QDYX can decrease cardial oxygen consumption in dogs, thus having protective effect on myocardial ischemia.
authors.affiliation: School of Badic Medical Sciences, Jilin University, Changchun 130021, Jilin, China.
authors.forename: Qiu-jing
authors.initials: QJ
authors.lastname: Wang
authors.forename: Weng-wei
authors.initials: WW
authors.lastname: Lu
authors.forename: Hang
authors.initials: H
authors.lastname: Lu
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Yang
authors.forename: Yu-qiang
authors.initials: YQ
authors.lastname: Hua
authors.forename: Shu-xia
authors.initials: SX
authors.lastname: Ji
mesh_terms: D000284:Administration, Oral; D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D031441:Ophiopogon / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027561:Salvia miltiorrhiza / Q000737:chemistry
chemical_list: D002316:Cardiotonic Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal