title: Concentrations of copper, iron, and zinc in the major organs of the wistar albino and wild black rats: a comparative study.
abstract: The concentrations of copper, iron, and zinc in the major organs of Wistar albino (Rattus norvegicus) and wild black rats (Rattus rattus) were measured by means of atomic absorption spectroscopy. The copper levels in the kidneys and liver of the Wistar albino rats (WARs) were significantly higher (p<0.05) than in the wild black rats (WBRs). There were no significant differences in the concentrations of zinc in the liver, lungs, kidneys, and brain between the two study groups, but zinc was significantly higher in the spleen (p<0.05) and lower in the heart (p<0.05) of WAR, compared to WBRs. Iron was significantly higher (p<0.05) in the heart and spleen of WBRs, compared to WARs. There were no extreme differences in the organ concentrations of trace elements between the two species, but, cumulatively, the WARs tend to have higher metallic concentrations in their system than the WBRs. The potential of these differences on the experimental results should not be overlooked and will serve as basis to further consider the complex interrelationships of these animals in their microenvironments and macroenvironments.
authors.affiliation: National Institute for Pharmaceutical Research and Development, Idu Industrial Estate, P.M.B. 21, Garki, Abuja, Nigerial.
authors.forename: A O
authors.initials: AO
authors.lastname: Olusola
authors.forename: O O
authors.initials: OO
authors.lastname: Obodozie
authors.forename: M
authors.initials: M
authors.lastname: Nssien
authors.forename: A
authors.initials: A
authors.lastname: Adaramoye
authors.forename: O
authors.initials: O
authors.lastname: Adesanoye
authors.forename: L E
authors.initials: LE
authors.lastname: Odama
authors.forename: G O
authors.initials: GO
authors.lastname: Emerole
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D008297:Male; D009115:Muridae / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar / Q000378:metabolism*; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution; D015032:Zinc / Q000378:metabolism*
chemical_list: D003300:Copper; D007501:Iron; D015032:Zinc