title: [Post-transfusion malaria: is the risk irreconciliable with biological silence?].
abstract: Despite the relatively high frequency of imported malaria in metropolitan France, the transmission of malaria by transfusion is exceptional. The screening of donations to determine those at risk is performed by an interview, and by the testing of serology for defined groups of donors. However, the exclusion of a candidate 'at risk' as a blood donor, by a pre-donation interview, is not completely mastered and the discrimination by biological examination lacks sensitivity, as much for methodological reasons as for reasons linked to the complex parasitic pathogenic agent (Plasmodium ssp.), as for the specific host defence system. The risk of introducing an unsafe-potentially dangerous (transfusion-transmitted malaria is often lethal)-element into the transfusional circuit is not completely covered. Is serology testing the most adequate test to avoid the risk of infected donations, in particular by Plasmodium falciparum; what are the alternatives and what will be the eventual added-costs of the biological qualification of such donations? The transfusional risk linked to Plasmodium seems, however, to be reduced to a minimum, concerning the circulation of plasma, which could represent an alternative for donors at real risk (rare) and those with a supposed risk (relatively numerous).
authors.affiliation: EFS Auvergne-Loire, 25, boulevard Pasteur, 42000 Saint-Etienne cedex 2, France. olivier.garraud@univ-st-etienne.fr
authors.forename: O
authors.initials: O
authors.lastname: Garraud
authors.forename: J
authors.initials: J
authors.lastname: Relave
authors.forename: P
authors.initials: P
authors.lastname: Flori
authors.forename: R
authors.initials: R
authors.lastname: Perraut
mesh_terms: D000818:Animals; D000852:Anopheles; D000913:Antibodies, Protozoan / Q000097:blood; D001782:Blood Donors; D001803:Blood Transfusion / Q000191:economics / Q000706:statistics & numerical data; D003365:Costs and Cost Analysis; D018562:Disease Transmission, Infectious; D005602:France / Q000453:epidemiology; D006801:Humans; D007299:Insect Bites and Stings / Q000150:complications / Q000469:parasitology; D007303:Insect Vectors; D008288:Malaria / Q000191:economics / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000635:transmission*; D016778:Malaria, Falciparum / Q000191:economics / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D008403:Mass Screening / Q000191:economics / Q000706:statistics & numerical data; D009032:Mosquito Control; D018512:Parasitemia / Q000453:epidemiology / Q000469:parasitology; D010961:Plasmodium / Q000276:immunology; D012306:Risk; D040242:Risk Reduction Behavior; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000191:economics / Q000706:statistics & numerical data; D065227:Transfusion Reaction; D014195:Travel
chemical_list: D000913:Antibodies, Protozoan