title: Pneumocystis carinii infection among human immunodeficiency virus (HIV) infected Myanmar patients.
abstract: A total of 60 HIV infected patients complaining of dry cough for at least two weeks and attending the Out-patient Department of the Specialist Hospital, Waibargi, were screened for Pneumocystis carinii. Induced sputum samples were examined with Giemsa and Gomori silver methenamine stains. P. carinii were detected in 18 patients (30%) with silver stain and 13 patients (21.7%) with Giemsa stain. The sensitivity and specificity of the Giemsa stain were 72.2% and 95.2%, respectively. The range of CD4 counts in P. carinii-positive patients was found to be 0-562/microl, and the mean CD4 count was 132.3/microl. Out of 18 P. carinii-positive cases, CD4 counts of 15 cases (83.3%) were <200/microl and those of 3 cases were >200/microl. Clinically, P. carinii-positive cases were associated with fever in 55.5%, with tightness of the chest in 38.9%, and with cyanosis and tightness of the chest in 11.1%. Co-infection with tuberculosis was found in 16.7%. Anti-pneumocystic prophylaxis is recommended for those patients with a CD4 count <200/microl. Giemsa staining could be used as an alternative diagnostic method for detecting P. carinii. This study documented the existing prevalence of P. carinii among HIV-infected Myanmar patients.
authors.affiliation: Parasitology Research Division, Department of Medical Research (Lower Myanmar), Waibargi, Myanmar.
authors.lastname: Kay-Thwe-Han
authors.lastname: Rai-Mra
authors.lastname: Htin-Aung-Saw
authors.lastname: Ye-Htut
authors.lastname: Wynn-Naing
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D001399:Azure Stains; D018791:CD4 Lymphocyte Count; D006801:Humans; D002052:Myanmar / Q000453:epidemiology; D045363:Pneumocystis carinii / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality; D015995:Prevalence; D012680:Sensitivity and Specificity; D016622:Silver Staining; D015996:Survival Rate
chemical_list: D001399:Azure Stains