Synthesis and cytotoxicity of a novel 1-alkylaminomethyl-2,4-diaryl-butadiene-1,3 fragment integrated within cyclohex(pent)enes.
A group of 1-alkylaminomethyl-2-aryl-3-arylidenecyclohex(pent)enes 3a-n with a 1-alkylaminomethyl-2,4-diaryl-1,3-butadiene fragment and a group of their congeners 3-alkylaminomethyl-1,2-diarylcyclohexene 7a-f have been synthesised for the first time. The conjugated system in 1-alkylaminomethyl-2-aryl-3-arylidenecyclohex(pent)enes 3a-n was unambiguously confirmed by X-ray crystallography. Cytotoxicity tests revealed that 3a-n possess inconsistent cytotoxicity against cancer cells, not their congeners 7a-f.
Zhao
Kejun
K
School of Pharmacy, Aston University, Birmingham, B4 7ET, UK.
Wang
Yongfeng
Y
Zhao
Linxiang
L
Ji
Zhizhong
Z
Li
Dan
D
Tisdale
Michael J
MJ
Schwalbe
Carl H
CH
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002070:Butadienes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003512:Cyclohexanones / Q000737:chemistry*; D003517:Cyclopentanes / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002070:Butadienes; D003512:Cyclohexanones; D003517:Cyclopentanes