What makes epothilones stick?
The potent epothilone tubulin polymerization promoters have been studied extensively by synthetic and SAR approaches. The paper by Buey et al. (, this issue of Chemistry & Biology) adds a new depth of mechanistic understanding by a careful analysis of the tubulin polymerization mechanism of the epothilones.
Kingston
David G I
DG
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
D034261:Epothilones / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry
D034261:Epothilones; D011725:Pyridines; D013844:Thiazoles; C093787:epothilone A; C023666:pyridine; C093788:epothilone B