Nodal, uterine and meningeal gamma(delta) T-cell lymphomas in cattle.
Three cases of bovine gamma(delta) T-cell lymphoma without skin involvement are described. Case 1 was a 17-month-old Holstein heifer with generalized lymphadenopathy. Case 2 was a 4-year-old Holstein cow that had multiple tumour masses in the uterine body and horns. Case 3, a 23-month-old Holstein bull was presented with generalized tremor, nystagmus and hyperesthaesia, and there were several tumour masses in the meninges. Cases 1 and 2 had epitheliotropic neoplastic infiltrates in the tonsillar epithelium and endometrial glands, respectively. Immunohistochemistry showed CD3+, WC1+, CD79a- lymphoma cells in all cases, and perforin was positive in two cases. Electron-dense granules were present in many neoplastic cells of all cases. These findings supported the cytotoxic gamma(delta) T-cell origin of the present lymphomas. Bovine gamma(delta) T-cell lymphoma may originate in a wide variety of anatomical sites and may be classified into several histological subtypes.
Tanaka
H
H
Hokkaido Research Station, National Institute of Animal Health, Toyohira, Sapporo, Japan.
Takai
H
H
Sato
K
K
Ishikawa
Y
Y
Shibahara
T
T
Kadota
K
K
D000818:Animals; D017252:CD3 Complex / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008224:Lymphoma, Follicular / Q000473:pathology / Q000662:veterinary; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008577:Meningeal Neoplasms / Q000473:pathology / Q000662:veterinary*; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D014594:Uterine Neoplasms / Q000473:pathology / Q000662:veterinary*
D017252:CD3 Complex; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D054353:Perforin