Graves' disease associated with Klinefelter's syndrome.
Klinefelter's syndrome is one of the most common forms of primary hypogonadism and infertility in males. It is characterized by small and firm testes, gynecomastia, azoospermia, and an elevated gonadotropin level. The frequencies of diabetes mellitus, breast cancer, and germ cell neoplasia increases in Klinefelter's syndrome. We report upon a 35 year-old male patient with Graves' disease in association with Klinefelter's syndrome; as confirmed by chromosome analysis. The patient is being treated with antithyroid medication for Graves' disease and by testosterone replacement for Klinefelter's syndrome.
Park
Jong-Suk
JS
Department of Internal Medicine, Yongdong Severance Hospital, Yonsei University College of Medicine, 146-92 Dogok-dong, Kangnam-gu, Seoul 135-720, Korea.
Kim
Chul-Sik
CS
Nam
Joo-Young
JY
Kim
Dol-Mi
DM
Yoon
Soo-Jee
SJ
Ahn
Chul-Woo
CW
Cha
Bong-Soo
BS
Lim
Sung-Kil
SK
Kim
Kyung-Rae
KR
Lee
Hyun-Chul
HC
Huh
Kap-Bum
KB
D000328:Adult; D006111:Graves Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008297:Male; D011877:Radionuclide Imaging