title: Giant cell tumor and Paget's disease of bone in one family: geographic clustering.
abstract: Giant cell tumor is a rare complication of Paget's disease of bone. Typically, this tumor occurs in the case of polyostotic disease and only in pagetic bones. This tumor rarely has been seen in multiple family members who have Paget's disease, although Paget's bone disease clearly has a hereditary component. Our report documents four cases of polyostotic Paget's bone disease complicated by benign giant cell tumor. In two patients, the giant cell tumor also was multifocal. All patients were from one family. They were born in Avellino and reside in Campania, a Southern Italian region. The ancestors of the patients with familial giant cell tumor in Paget's bone disease were born in the same geographic area. These data suggest that a combination of environmental and genetic factors could be responsible for linkage of the patients born in Avellino with this neoplasm that is highly unusual in patients with Paget's disease of bone.
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Rendina
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mossetti
authors.forename: Ernesto
authors.initials: E
authors.lastname: Soscia
authors.forename: Cesare
authors.initials: C
authors.lastname: Sirignano
authors.forename: Luigi
authors.initials: L
authors.lastname: Insabato
authors.forename: Roberto
authors.initials: R
authors.lastname: Viceconti
authors.forename: Rosa
authors.initials: R
authors.lastname: Ignarra
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Nunziata
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000209:etiology* / Q000235:genetics; D004777:Environment; D005190:Family; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000209:etiology* / Q000235:genetics; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications* / Q000235:genetics; D010375:Pedigree