title: Clinical and radiographic evaluation of Emdogain as a regenerative material in the treatment of interproximal vertical defects in chronic and aggressive periodontitis patients.
abstract: This study evaluated the efficacy of Emdogain enamel matrix proteins as a regenerative material in interproximal vertical defects both clinically and radiographically. Patients aged 18 to 45 years and diagnosed with chronic or aggressive periodontitis were included. Sixteen intrabony defects in eight patients were surgically treated using a split-mouth design. Emdogain placement was done at experimental sites. Since both chronic and aggressive periodontitis patients were included, an attempt was made to interpret results between the two types of cases. Postsurgical measurements at 9 months revealed no significant difference in mean pocket depth reduction, clinical attachment level gain, amount of defect fill, or defect resolution between control and experimental groups. Mean pocket depth reduction and amount of defect fill were significant in both groups. The results were interpreted separately for chronic and aggressive periodontitis cases. This study demonstrated no added advantage of using Emdogain compared to surgical debridement alone. Further long-term and large-sample-size evaluation is required to prove Emdogain's consistent efficacy.
authors.affiliation: Department of Periodontics, College of Dental Sciences, Rajiv Gandhi University of Health Sciences, Bangalore, India. vanrajs@hotmail.com
authors.forename: K L
authors.initials: KL
authors.lastname: Vandana
authors.forename: Kinnari
authors.initials: K
authors.lastname: Shah
authors.forename: Shobha
authors.initials: S
authors.lastname: Prakash
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D001861:Bone Regeneration / Q000187:drug effects*; D002908:Chronic Disease; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000601:surgery*; D011859:Radiography; D016745:Root Planing
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins