title: [Immune response to vaccination by Grippol in female northerners from Arkhagel'sk].
abstract: The immune-system condition of virtually healthy subjects (aged 35-45) was studied before vaccination ("Grippol") and 1 week later. An intense formation of antibodies to virus hemagglutinin is associated with lymphoproliferative reaction combined with differentiation of immune-competent cells (ICC) and with a higher phagocyte activity. A lack of any changed reactions to the administered antigen is interrelated with a deficit of phagocyte protection and with an activated ICC apoptosis.
authors.forename: L S
authors.initials: LS
authors.lastname: Shegoleva
authors.forename: L P
authors.initials: LP
authors.lastname: Zhilina
authors.forename: V F
authors.initials: VF
authors.lastname: Fardzinova
authors.forename: L K
authors.initials: LK
authors.lastname: Dobrodeeva
mesh_terms: D000328:Adult; D001110:Arctic Regions; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology* / Q000517:prevention & control*; D008875:Middle Aged; D012426:Russia; D014611:Vaccination
chemical_list: C408342:Grippol; D007252:Influenza Vaccines