title: New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation.
abstract: New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV, I-16132 Genoa, Italy. schensil@unige.it
authors.forename: S
authors.initials: S
authors.lastname: Schenone
authors.forename: O
authors.initials: O
authors.lastname: Bruno
authors.forename: A
authors.initials: A
authors.lastname: Ranise
authors.forename: F
authors.initials: F
authors.lastname: Bondavalli
authors.forename: C
authors.initials: C
authors.lastname: Brullo
authors.forename: P
authors.initials: P
authors.lastname: Fossa
authors.forename: L
authors.initials: L
authors.lastname: Mosti
authors.forename: G
authors.initials: G
authors.lastname: Menozzi
authors.forename: F
authors.initials: F
authors.lastname: Carraro
authors.forename: A
authors.initials: A
authors.lastname: Naldini
authors.forename: C
authors.initials: C
authors.lastname: Bernini
authors.forename: F
authors.initials: F
authors.lastname: Manetti
authors.forename: M
authors.initials: M
authors.lastname: Botta
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010766:Phosphorylation / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D019061:src-Family Kinases / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D011743:Pyrimidines; D019061:src-Family Kinases