title: Explosive-aggressive behavior related to bilateral subthalamic stimulation.
abstract: We describe a patient with Parkinson's Disease who underwent bilateral subthalamic nucleus deep brain stimulation and later presented with episodes of aggressive behavior disorder with disturbed impulse control and an inability to control anger likely related to the deep brain stimulation "switch-on stimulation". We hypothesize that increasing voltage intensity could influence neighboring passing fibers coming from basal limbic system that are involved in the regulation of affect and emotional behavior. We suggest investigating these neuropsychological disturbances considering their influence on quality of life after surgery.
authors.affiliation: Dipartimento di Neuroscienze applicate alla clinica, U.O. Neurologia, Azienda Ospedaliera Universitaria S. Anna, Hospital of Ferrara, Corso Giovecca 203, Ferrara 44100, Italy. chiasen@mailcity.com
authors.forename: M
authors.initials: M
authors.lastname: Sensi
authors.forename: R
authors.initials: R
authors.lastname: Eleopra
authors.forename: M A
authors.initials: MA
authors.lastname: Cavallo
authors.forename: E
authors.initials: E
authors.lastname: Sette
authors.forename: P
authors.initials: P
authors.lastname: Milani
authors.forename: R
authors.initials: R
authors.lastname: Quatrale
authors.forename: J G
authors.initials: JG
authors.lastname: Capone
authors.forename: V
authors.initials: V
authors.lastname: Tugnoli
authors.forename: M R
authors.initials: MR
authors.lastname: Tola
authors.forename: E
authors.initials: E
authors.lastname: Granieri
authors.forename: P G
authors.initials: PG
authors.lastname: Data
mesh_terms: D000374:Aggression / Q000523:psychology*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000523:psychology*; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010300:Parkinson Disease / Q000523:psychology / Q000601:surgery; D020531:Subthalamic Nucleus