Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains.
Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5 microM and to form III (linear) at a concentration of 50 microM. A possible mechanism of superoxide anion was provided.
Qian
Xuhong
X
State Key Laboratory of Fine Chemicals, Dalian University of Technology, PO Box 40, 158 Zhongshan Road, Dalian 116012, China. xhqian@dlut.edu.cn
Li
Yonggang
Y
Xu
Yufang
Y
Liu
Yan
Y
Qu
Baoyuan
B
D000588:Amines; D000818:Animals; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects; D015195:Drug Design; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis / Q000494:pharmacology*; D007094:Imides; D008027:Light; D010782:Photolysis; D010957:Plasmids / Q000187:drug effects / Q000528:radiation effects; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013440:Sulfides
D000588:Amines; D006576:Heterocyclic Compounds, 4 or More Rings; D007094:Imides; D011838:Radiation-Sensitizing Agents; D013440:Sulfides; D004247:DNA; C427203:calf thymus DNA