The control by angiotensin II of cholesterol supply for aldosterone biosynthesis.
In the adrenal glomerulosa cell, aldosterone is synthesized from cholesterol, which is supplied to the cell and stored under the form of cholesterol esters, then hydrolyzed to be transferred to the mitochondrial outer membrane and finally transported to the inner membrane where the P450 side-chain cleavage enzyme will convert it to pregnenolone. Angiotensin II (AngII), one of the major physiological regulators of mineralocorticoid synthesis, appears to affect most of the steps along this cascade and thus to exert a powerful control over the use of cholesterol for aldosterone production.
Capponi
Alessandro M
AM
Division of Endocrinology, Diabetology and Nutrition, Faculty of Medicine, University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14, Switzerland. alessandro.capponi@medecine.unige.ch
D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D002417:Cattle; D002788:Cholesterol Esters / Q000378:metabolism*; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008901:Mineralocorticoids / Q000096:biosynthesis; D008928:Mitochondria / Q000201:enzymology*; D011284:Pregnenolone / Q000096:biosynthesis; D051381:Rats; D015384:Zona Glomerulosa / Q000378:metabolism*
D002788:Cholesterol Esters; D008901:Mineralocorticoids; D000804:Angiotensin II; D000450:Aldosterone; D011284:Pregnenolone; D002786:Cholesterol Side-Chain Cleavage Enzyme