title: No mutations in the GATA-1 gene detected in patients with acquired essential thrombocythemia.
abstract: Mutations in the GATA-1 gene have been identified in patients with familial macrothrombocytopenia and Down's syndrome patients with a transient myeloproliferative disorder and/or acute megakaryoblastic leukemia. We screened this gene in 46 patients with essential thrombocythemia and identified only a common single nucleotide polymorphism that is unlikely to be of pathological significance.
authors.forename: Domenica
authors.initials: D
authors.lastname: Gandini
authors.forename: Anthony J R
authors.initials: AJ
authors.lastname: Allen
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Nash
authors.forename: David C
authors.initials: DC
authors.lastname: Linch
authors.forename: Rosemary E
authors.initials: RE
authors.lastname: Gale
mesh_terms: D000818:Animals; D005260:Female; D050982:GATA1 Transcription Factor / Q000235:genetics*; D018922:HL-60 Cells; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013920:Thrombocythemia, Essential / Q000235:genetics*
chemical_list: D050982:GATA1 Transcription Factor