Disruption of mice sleep stages induced by low doses of organophosphorus compound soman.
We have explored during 7 days, EEG spectral response and sleep pattern of mice after a mild intoxication with soman. Using an automatic staging method, we have quantified the sleep stage of the mice to identify disruptions of the sleep pattern. The 50 microg/kg dose of soman produced several effects during several time windows after intoxication. A first decrease followed by an increase of theta energy, a disturbance of slow wave sleep during 5 days and an increase of the REM sleep during the first and second day after intoxication. During the first 6h, we have observed some effects which were not consistent with a muscarinic activation and might have involved GABA-ergic system. After this early period, the observed effects were in accordance with a muscarinic activation. We observed an increase of energy in the EEG theta band during 3 days after soman injection and an increase of slow wave sleep during the second to the fifth day after soman injection.
Crouzier
David
D
Centre de Recherches du Service Santé des Armées, 24, Avenue des Maquis du Grésivaudan, BP 87 n38, 702 La Tronche Cedex, France.
Le Crom
Valerie Baille
VB
Four
Elise
E
Lallement
Guy
G
Testylier
Guy
G
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D002940:Circadian Rhythm; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004576:Electromyography; D008297:Male; D051379:Mice; D012894:Sleep Stages / Q000187:drug effects* / Q000502:physiology; D012999:Soman / Q000008:administration & dosage / Q000633:toxicity*
D002800:Cholinesterase Inhibitors; D012999:Soman