Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature.
Neutropenic enterocolitis (NE) is an unusual acute complication of neutropenia, most often associated with leukemia and lymphoma which is characterized by segmental cecal and ascending colon ulceration that may progress to necrosis, perforation, and septicemia. We present a case of neutropenic enterocolitis in a patient with non-small-cell lung cancer who received docetaxel and flavopiridol as part of a phase I clinical trial and review cases in the literature where docetaxel was involved. Given the increased use of docetaxel and other taxanes in the treatment of advanced lung cancer, physicians should be aware of this potential toxicity of therapy.
D'Amato
Gina
G
Experimental Therapeutics and Thoracic Oncology Programs, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA.
Rocha Lima
Caio
C
Mahany
J J
JJ
Muro-Cacho
Carlos
C
Haura
Eric B
EB
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D017321:Clinical Trials, Phase I as Topic; D000077143:Docetaxel; D044504:Enterocolitis, Neutropenic / Q000139:chemically induced* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005419:Flavonoids; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D010880:Piperidines; D043823:Taxoids / Q000009:adverse effects*
D000970:Antineoplastic Agents; D005419:Flavonoids; D010880:Piperidines; D043823:Taxoids; D000077143:Docetaxel; C077990:alvocidib