[Effect of the toxic chemicals in low doses on phospholipid composition of the animal liver].
We analyzed phospholipid composition in the liver 7, 14, and 31 days after single oral administration of oil solution of hexane-ether extracts from potable water sources with different content of benzo[a]pyrene and polychlorobiphenyls. Neither linear effect-dose relationship nor directed correlations between individual phospholipid fractions and generalized indices of their composition have been revealed, which indicates high sensitivity and no normalization of phospholipid composition in mouse liver one month after administration of toxicants.
Urnysheva
V V
VV
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991 Russia.
Shishkina
L N
LN
D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D002308:Cardiolipins / Q000737:chemistry / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010712:Phosphatidic Acids / Q000032:analysis; D010713:Phosphatidylcholines / Q000032:analysis; D010714:Phosphatidylethanolamines / Q000032:analysis; D010743:Phospholipids / Q000737:chemistry* / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000633:toxicity; D012044:Regression Analysis; D013997:Time Factors; D036401:Toxicity Tests, Chronic; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D002308:Cardiolipins; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D014874:Water Pollutants, Chemical; D001564:Benzo(a)pyrene; C483858:phosphatidylethanolamine; D011078:Polychlorinated Biphenyls