[Mechanisms of psychotropics' action in relation to CNS neurogenesis].
Newly available psychotropics seem to put the practical psychiatry to a stage of reform. In addition, the recent advancements in the study of neurogenesis in the adult brain force the change of the therapeutic strategy of mental disorders. The fact that the central nervous tissues can repair even after the maturation and that the replacement of neurons continues during adulthood will alter our understanding about their pathogenesis. The action of several psychiatric medications such as antidepressants, mood stabilizers, antipsychotics, and electroconvulsive therapy is converging at neurogenesis and/or neuroprotection. When the validity of the "neurogenesis/neuroprotection hypothesis" of psychiatric medication will be proved in psychiatric practice, we can establish a more rational and more effective treatment of mental disorders.
Ujihara
Hisamitsu
H
Division of Psychiatry, Geisei Hospital, Aki-gun, Kochi, Japan. ujiharah@sa2.so-net.ne.jp
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D004597:Electroshock; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy* / Q000503:physiopathology; D009416:Nerve Regeneration / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D018696:Neuroprotective Agents; D011619:Psychotropic Drugs / Q000494:pharmacology
D018696:Neuroprotective Agents; D011619:Psychotropic Drugs