The evolution of molecular genetic pathways and networks.
There is growing interest in the evolutionary dynamics of molecular genetic pathways and networks, and the extent to which the molecular evolution of a gene depends on its position within a pathway or network, as well as over-all network topology. Investigations on the relationships between network organization, topological architecture and evolutionary dynamics provide intriguing hints as to how networks evolve. Recent studies also suggest that genetic pathway and network structures may influence the action of evolutionary forces, and may play a role in maintaining phenotypic robustness in organisms.
Cork
Jennifer M
JM
Department of Genetics, North Carolina State University, Raliegh, NC 27695, USA.
Purugganan
Michael D
MD
D000818:Animals; D019143:Evolution, Molecular; D023281:Genomics; D006801:Humans; D008957:Models, Genetic; D008967:Molecular Biology; D010641:Phenotype