[Search for the association of polymorphic markers for genes coding for antioxidant defense enzymes, with development of diabetic polyneuropathies in patients with type 1 diabetes mellitus].
The allele and genotype frequency distributions of polymorphic markers of genes coding for antioxidant enzymes were compared for type 1 diabetes mellitus patients with or without diabetic polyneuropathy (DPN). The groups (total 180 patients) had nonoverlapping (polar) phenotypes. Group DPN+ included 86 patients with DPN and diabetic record no more than 5 years. Control group DPN- included patients without DPN and diabetic record of at least 10 years. Comparative analysis with Fisher's exact test revealed a significant difference in allele and genotype frequency distributions of the T(-262)C polymorphic marker of the CAT gene. Polymorphic markers C1167T of the CAT gene, Pro/Leu of the GPX1 gene, 0/+ of the GSTT1 gene, and 0/+ of the GSTM1 gene showed no significant difference in allele or genotype frequency distribution. On this evidence, these markers were not associated with DPN in the sample examined.
Zotova
E V
EV
State Research Center GosNIIGenetika, Moscow, 117545 Russia. lena-zotova@mail.ru
Savost'ianov
K V
KV
Chistiakov
D A
DA
Bursa
T R
TR
Galeev
I V
IV
Strokov
I A
IA
Nosikov
V V
VV
D000293:Adolescent; D000328:Adult; D001483:Base Sequence; D002374:Catalase / Q000235:genetics*; D002648:Child; D017931:DNA Primers; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*
D017931:DNA Primers; D005819:Genetic Markers; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase