title: Treatment of small lungworm infestation in sheep by using moxidectin.
abstract: The use of moxidectin (MXD) in the treatment of small lungworm infestation (Cystocaulus ocreatus, Muellerius capillaris, Neostrongylus linearis and Protostronglylus rufescens) in sheep, was evaluated. Twenty-one sheep naturally infested with small lungworms, were divided into three groups (n = 7) and treated as follows: group A with moxidectin 1% injectable solution at a dose rate of 0.2mgkg(-1) bodyweight, group B with moxidectin 0.1% oral drench at a dose rate of 0.2 mgkg(-1) bodyweight and group C being controls. Before treatment, mean faecal larval counts were 30.7, 21.1 and 26.7 lpg in group A, B and C, respectively; 14 days after treatment respective counts were 0.4, 2.3 and 63.0 lpg, (percentage reduction after moxidectin administration >96.0%); 60 days after treatment respective counts were 0.0, 0.0 and 26.4 lpg, (percentage reduction after moxidectin administration 100%). It is concluded that treatment of small lungworm infestation of sheep can be effected by using moxidectin.
authors.affiliation: School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Papadopoulos
authors.forename: S
authors.initials: S
authors.lastname: Sotiraki
authors.forename: C
authors.initials: C
authors.lastname: Himonas
authors.forename: G C
authors.initials: GC
authors.lastname: Fthenakis
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D008168:Lung / Q000469:parasitology; D018942:Macrolides / Q000627:therapeutic use*; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy / Q000469:parasitology*; D018709:Statistics, Nonparametric; D014132:Trachea / Q000469:parasitology; D014251:Trichostrongyloidea / Q000254:growth & development*; D014252:Trichostrongyloidiasis / Q000188:drug therapy* / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000969:Antinematodal Agents; D018942:Macrolides; C027837:moxidectin