Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures.
The effect of histamine H(3) antagonist, iodophenpropit on amygdaloid kindled seizures in rats was studied in comparison with those of other H(3) antagonists. Under pentobarbital anesthesia, the rats were fixed to a stereotaxic apparatus and bipolar electrodes were implanted into the amygdala. Electrodes were connected to a miniature receptacle, which was embedded in the skull with dental cement. To cause kindled seizures, electrical stimulation was applied to the amygdala bipolarly every day by a constant current stimulator, and electroencephalogram and convulsive behavior were observed. Drug effects were estimated in rats showing generalized kindled seizures. Intraperitoneal injection of H(3) antagonists, iodophenpropit, thioperamide, AQ0145 and clobenpropit, resulted in a dose-related inhibition of amygdaloid kindled seizures. The effect of iodophenpropit on amygdaloid kindled seizures was more potent than those of thioperamide, AQ0145 and clobenpropit. In conclusion, iodophenpropit may be useful for the treatment of partial epilepsy and/or secondary generalized seizures in humans.
Harada
Chie
C
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
Fujii
Yoko
Y
Hirai
Tadashi
T
Shinomiya
Kazuaki
K
Kamei
Chiaki
C
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation / Q000379:methods; D006633:Histamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018100:Receptors, Histamine H3 / Q000502:physiology*; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology
D006633:Histamine Antagonists; D007093:Imidazoles; D018100:Receptors, Histamine H3; D007550:Isothiuronium; C077791:iodophenpropit