title: HCV and associated concomitant infections at Sharkia Governorate, Egypt.
abstract: The natural history of hepatitis C virus (HCV) infection has a highly variable course. Many patients develop chronic infection, with its consequent risk of cirrhosis, liver failure and hepatocellular carcinoma. A key question is whether patients at high risk of disease progression can be distinguished from those with relatively benign disease course. The disease progression is influenced by other factors such as duration of infection, age at infection, sex, co-infection with hepatitis B virus (HBV), Epstein Bar virus (EBV), cytomegalovirus (CMV), the level of HCV viraemia and its type. Other endemic infections in the community as bilharziasis may have a role in progression of the condition to serious complications. These factors are correlated with newly proposed grades and stages of the disease. The studied (109) cases were divided into 6 groups according to the concomitant infection with HCV. The result proved that groups 1, 3 & 5 had a higher level of viraemia than other groups, and to be the high-risk groups as 56.4% and 34.6% were in G2S2 and G3S3, respectively. All cases of liver cell dysplasia and hepatocellular carcinoma in this study were seen in these groups. The conclusion showed that these factors play an important role in the progression of HCV infection. Death of the patients of this progressive condition occurs in younger age and is more due to liver failure than to HCC.
authors.affiliation: Faculty of Medicine, Zagazig University, Zagazig, Egypt.
authors.forename: Amal M
authors.initials: AM
authors.lastname: Mangoud
authors.forename: Mostafa H
authors.initials: MH
authors.lastname: Eissa
authors.forename: Essam I
authors.initials: EI
authors.lastname: Sabee
authors.forename: Ibrahem A
authors.initials: IA
authors.lastname: Ibrahem
authors.forename: Alaa
authors.initials: A
authors.lastname: Ismail
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
authors.forename: Samia
authors.initials: S
authors.lastname: Etewa
authors.forename: Seham
authors.initials: S
authors.lastname: Mahrous
authors.forename: Essam
authors.initials: E
authors.lastname: Nor Edin
authors.forename: Yousry
authors.initials: Y
authors.lastname: Mostafa
authors.forename: Yousry
authors.initials: Y
authors.lastname: Abouel-Magd
authors.forename: Afefy F
authors.initials: AF
authors.lastname: Afefy
authors.forename: Eman
authors.initials: E
authors.lastname: el-Shorbagy
authors.forename: Mahmoud
authors.initials: M
authors.lastname: el-Sedawy
authors.forename: Hosenia
authors.initials: H
authors.lastname: Ragab
authors.forename: Mostafa I
authors.initials: MI
authors.lastname: Hassan
authors.forename: Khalid
authors.initials: K
authors.lastname: Lakouz
authors.forename: Khalid
authors.initials: K
authors.lastname: Abdel-Aziz
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Saber
authors.forename: Gaber
authors.initials: G
authors.lastname: el-Hady
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000453:epidemiology; D018450:Disease Progression; D004534:Egypt / Q000453:epidemiology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012552:Schistosomiasis / Q000150:complications* / Q000453:epidemiology; D014766:Viremia / Q000453:epidemiology