title: Synthesis and anti-inflammatory effect of lipophilic derivatives of threo-DL-phenylserine in rat experimental edema.
abstract: Novel N- and O-acyl derivatives of threo-DL-phenylserine containing lipophilic long chain carboxylic or aryl(sulfon)amide groups were synthesized. Anti-inflammatory activity in carrageenin-induced paw edema model in rats was studied. Compound 10 had the most expressed anti-inflammatory effect over 24 h.
authors.affiliation: Institute of Biochemistry, Vilnius, Lithuania.
authors.forename: N
authors.initials: N
authors.lastname: Dirvianskyte
authors.forename: L
authors.initials: L
authors.lastname: Leonaviciene
authors.forename: R
authors.initials: R
authors.lastname: Bradünaite
authors.forename: V
authors.initials: V
authors.lastname: Razumas
authors.forename: E
authors.initials: E
authors.lastname: Butkus
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005528:Foot / Q000473:pathology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012694:Serine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D012694:Serine; D002351:Carrageenan