title: Nodular immunocyte-derived (AL) amyloidosis in the trachea of a dog.
abstract: A 7-year-old castrated male Miniature Schnauzer was examined because of labored breathing and episodes of respiratory distress that progressed to collapse. On cervical radiographs, a focal soft tissue mass in the caudal cervical portion of the trachea was observed, and during tracheoscopy, a 1 x 1 cm, pedunculated, multinodular, pink, intraluminal mass extending from the dorsal tracheal membrane and obstructing approximately 80% of the tracheal lumen was seen. Tracheal resection and anastomosis was performed to remove the mass, and the dog recovered without complications. On histologic examination, the mass consisted of a large accumulation of homogeneous, faintly fibrillar eosinophilic material admixed with a predominantly plasma cell infiltrate; examination of sections stained with thioflavin T and Congo red stain confirmed that the eosinophilic material was amyloid. A diagnosis of nodular, immunocyte-derived (AL) amyloidosis was made. Seventeen months after surgery, the dog had a relapse of respiratory distress because of an extramedullary plasmacytoma involving the trachea.
authors.affiliation: Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors.forename: M Faulkner
authors.initials: MF
authors.lastname: Besancon
authors.forename: Brian A
authors.initials: BA
authors.lastname: Stacy
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Kyles
authors.forename: Peter F
authors.initials: PF
authors.lastname: Moore
authors.forename: William
authors.initials: W
authors.lastname: Vernau
authors.forename: Sean D
authors.initials: SD
authors.lastname: Smarick
authors.forename: Liberty A
authors.initials: LA
authors.lastname: Rasor
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D000714:Anastomosis, Surgical / Q000662:veterinary; D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis / Q000601:surgery*; D004285:Dogs; D004724:Endoscopy / Q000662:veterinary; D008297:Male; D011859:Radiography; D012131:Respiratory Insufficiency / Q000209:etiology / Q000662:veterinary; D014132:Trachea / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014133:Tracheal Diseases / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*