Progressive beta cell failure in type 2 diabetes mellitus of youth.
The pathophysiology of type 2 diabetes mellitus (T2DM) involves insulin resistance and insulin deficiency. We report the progression in insulin sensitivity and secretion over a 6-year period in an adolescent with T2DM. This report further demonstrates that the earliest abnormality in youth T2DM is insulin resistance followed by progressive beta-cell failure.
Gungor
Neslihan
N
Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children's Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Arslanian
Silva
S
D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000503:physiopathology*