Myocardial perfusion measurements by spin-labeling under different vasodynamic states.
In this study absolute myocardial perfusion was determined using a spin-labeling magnetic resonance imaging (MRI) technique at 2 Tesla. The technique was applied to 16 healthy volunteers at resting conditions, adenosine-induced stress, and oxygen breathing. Overall myocardial quantitative perfusion was determined as 2.3 +/- 0.8 mL/g/min (rest), 4.2 +/- 1.0 mL/g/min (adenosine), and 1.6 +/- 0.6 mL/g/min (oxygen), respectively. T1 of left ventricular blood pool decreased from 1709 +/- 101 ms (rest) to 1423 +/- 61 ms (oxygen), whereas T1 of right ventricular blood did not change significantly (1586 +/- 126 ms and 1558 +/- 150 ms). In conclusion, the presented technique for quantification of myocardial perfusion is an alternative to contrast agent-based methods. The spin labeling method is noninvasive and easily repeatable and it could therefore become an important tool to study changes in myocardial perfusion under different vasodynamic states.
Fidler
Florian
F
Department of Biophysics (EP5), University of Wuerzburg, Josef-Schneider-Str. 2, 97080 Wuerzburg, Germany.
Wacker
Christian M
CM
Dueren
Christian
C
Weigel
Matthias
M
Jakob
Peter M
PM
Bauer
Wolfgang R
WR
Haase
Axel
A
D000241:Adenosine; D000328:Adult; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008955:Models, Cardiovascular; D009206:Myocardium / Q000473:pathology*; D010100:Oxygen / Q000008:administration & dosage; D012146:Rest; D013113:Spin Labels; D014665:Vasodilator Agents; D016276:Ventricular Function
D013113:Spin Labels; D014665:Vasodilator Agents; D000241:Adenosine; D010100:Oxygen