HIV-associated primary body-cavity-based lymphoma: clinico-biologic features in three patients diagnosed at the same institution.
Primary effusion lymphoma (PEL) is a recently individualized form of non-Hodgkin lymphoma (WHO classification) that mainly develops in HIV infected males, more frequently in homosexuals and advanced stages of the disease (total CD4+ lymphocyte count below 100-200/mL). Occasionally, it appears in others immunodepressive states (such as solid organs postransplant period) and even, although very rarelly, in immunocompetents patients. From a pathogenetic point of view, PEL has been related to Kaposi's sarcoma-associated herpes virus (also named human herpesvirus 8) and to the clinical antecedent of Kaposís sarcoma. Relative unfrequency of this disease, the absence of wide casuistics allowing a better characterization, and its unfavorable outcome, support the need of a deeper knowledge. We present here the clinical-biological findings of three patients that were diagnosed of pleural PEL in our institution in the last two years.
Rodríguez Salazar
M J
MJ
Servicio de Hematología, Hospital Universitario de Canarias, La Laguna. Santa Cruz de Tenerife, Spain.
Raya Sánchez
J M
JM
Rodríguez Sánchez
R
R
Alonso Socas
M M
MM
Brito Barroso
M L
ML
Hernández Nieto
L
L
D000328:Adult; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000473:pathology / Q000821:virology; D008297:Male; D010994:Pleura / Q000473:pathology / Q000821:virology; D035422:Pleural Cavity / Q000473:pathology* / Q000821:virology