The archaeal sensory rhodopsin II/transducer complex: a model for transmembrane signal transfer.
Archaebacterial photoreceptors mediate phototaxis by regulating cell motility through two-component signalling cascades. Homologs of this sensory pathway occur in all three kingdoms of life, most notably in enteric bacteria in which the chemotaxis has been extensively studied. Recent structural and functional studies on the sensory rhodopsin II/transducer complex mediating the photophobic response of Natronomonas pharaonis have yielded new insights into the mechanisms of signal transfer across the membrane. Electron paramagnetic resonance data and the atomic resolution structure of the receptor molecule in complex with the transmembrane segment of its cognate transducer provided a model for signal transfer from the receptor to the cytoplasmic side of the transducer. This mechanism might also be relevant for eubacterial chemoreceptor signalling.
Klare
Johann P
JP
Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.
Gordeliy
Valentin I
VI
Labahn
Jörg
J
Büldt
Georg
G
Steinhoff
Heinz-Jürgen
HJ
Engelhard
Martin
M
D019843:Archaeal Proteins / Q000737:chemistry* / Q000378:metabolism; D002338:Carotenoids / Q000737:chemistry* / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology*; D004578:Electron Spin Resonance Spectroscopy; D046911:Macromolecular Substances; D008958:Models, Molecular; D011487:Protein Conformation; D025604:Rhodopsins, Microbial / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D019843:Archaeal Proteins; D046911:Macromolecular Substances; D025604:Rhodopsins, Microbial; C434450:phototaxis receptor sensory rhodopsin II, Natronobacterium pharaonis; D002338:Carotenoids