Strategic approaches to osteoporosis in transplantation.
Recipients of stem cell transplantation are at risk for osteopenia and osteoporosis. Longitudinal studies performed in adults have shown that significant bone demineralization occurs following myeloablative therapy and subsequent immune suppression. Among children and adolescents, cross-sectional analyses indicate that younger patients are also at risk for long-term bone toxicity. Strategies to detect and manage this disorder in pediatric SCT recipients are presented.
Mattano
Leonard A
LA
Division of Pediatric Hematology/Oncology, Michigan State University/Kalamazoo Center for Medical Studies, Kalamazoo, MI 49007, USA. mattano@umich.edu
D000293:Adolescent; D015519:Bone Density; D002648:Child; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D010024:Osteoporosis / Q000209:etiology* / Q000517:prevention & control*; D012307:Risk Factors