title: Assessment of human pulmonary function using oxygen-enhanced T(1) imaging in patients with cystic fibrosis.
abstract: Indirect qualitative MRI of pulmonary function is feasible using the paramagnetic effects of oxygen physically dissolved in blood. In this study, a more quantitative oxygen-enhanced pulmonary function test based on the slope of a plot of R(1) vs. oxygen concentration-the oxygen transfer function (OTF)-was developed and tested in a pool of five healthy volunteers and five patients with cystic fibrosis (CF). The lung T(1) relaxation rate, R(1), under normoxic conditions (room air, 21% O(2)), and the response to various hyperoxic conditions (40%-100% O(2)) were studied. Lung T(1) in healthy volunteers showed a relatively homogeneous distribution while they breathed room air, and a homogeneous decrease under hyperoxic conditions. Lung T(1) in CF patients showed an inhomogeneous distribution while they breathed room air, and the observed lung T(1) decrease under hyperoxia depended on the actual state of the diseased lung tissue. In the selected group of CF patients, areas with reduced OTF also showed reduced perfusion, as confirmed by qualitative contrast-enhanced MR pulmonary perfusion imaging. The results demonstrate that this completely noninvasive oxygen-enhanced pulmonary function test has potential for clinical applications in the serial diagnosis of lung diseases such as CF. .
authors.affiliation: Department of Physics, University of Würzburg, Würzburg, Germany. peja@physik.uni-wuerzburg.de
authors.forename: Peter M
authors.initials: PM
authors.lastname: Jakob
authors.forename: Tungte
authors.initials: T
authors.lastname: Wang
authors.forename: Georg
authors.initials: G
authors.lastname: Schultz
authors.forename: Helge
authors.initials: H
authors.lastname: Hebestreit
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hebestreit
authors.forename: Dietbert
authors.initials: D
authors.lastname: Hahn
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen
chemical_list: D010100:Oxygen