Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men.
OBJECTIVE
To investigate the effect of moderate changes in dietary fatty acid profile on postprandial risk factors for cardiovascular disease (CVD).


METHODS
Double-blind, randomised, crossover, intervention trial.


METHODS
: University of Auckland Human Nutrition Unit, New Zealand.


METHODS
A total of 18 lean healthy men.


METHODS
A dairy butter fat modified to reduce the saturated:unsaturated fatty acid ratio and a conventional high saturated butter fat were given on two separate occasions as a high-fat test meal (59+/-4 g fat; 71 en% fat) at breakfast. A fat exclusion lunch, dinner and snacks were also given. Blood samples were collected at 0 (baseline), 1, 3, 6, 10 and 24 h.


RESULTS
Maximum peak in total triacylglycerol (TAG) occurred 3 h postprandially and was highest on modified treatment (diet, P<0.05) due predominantly to increased TAG within the chylomicron-rich fraction. Transient peaks in total-, LDL- and HDL-cholesterol occurred postprandially, but did not differ between dietary treatments (P>0.05). There were no differential effects of diet on postprandial free fatty acids, apo A, apo B, glucose, insulin, amylin or haemostatic clotting factors (P>0.05).


CONCLUSIONS
In a group of healthy young men, replacement of 16% of total saturated fatty acids by mono- and polyunsaturated fats within a dairy lipid did not induce postprandial changes in CVD risk that may be considered beneficial for health.


BACKGROUND
Fonterra, Wellington; New Zealand.
Poppitt
S D
SD
Department of Medicine, University of Auckland, New Zealand. s.poppitt@auckland.ac.nz
Keogh
G F
GF
Mulvey
T B
TB
Phillips
A
A
McArdle
B H
BH
MacGibbon
A K H
AK
Cooper
G J S
GJ
D002079:Butter; D002318:Cardiovascular Diseases / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D004311:Double-Blind Method; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D019518:Postprandial Period; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D008055:Lipids; D014280:Triglycerides; D002079:Butter; D002784:Cholesterol