title: Retrospective time-trend study of polybrominated diphenyl ether and polybrominated and polychlorinated biphenyl levels in human serum from the United States.
abstract: Six polybrominated diphenyl ethers (PBDEs), one hexabromobiphenyl [polybrominated biphenyl (PBB)], and one hexachlorobiphenyl [polychlorinated biphenyl (PCB)] were measured in 40 human serum pools collected in the southeastern United States during 1985 through 2002 and in Seattle, Washington, for 1999 through 2002. The concentrations of most of the PBDEs, which are commercially used as flame retardants in common household and commercial applications, had significant positive correlations with time of sample collection, showing that the concentrations of these compounds are increasing in serum collected in the United States. In contrast, PCB and PBB levels were negatively correlated with sample collection year, indicating that the levels of these compounds have been decreasing since their phaseout in the 1970s.
authors.affiliation: Organic Analytical Toxicology Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3717, USA. asjodin@cdc.gov
authors.forename: Andreas
authors.initials: A
authors.lastname: Sjödin
authors.forename: Richard S
authors.initials: RS
authors.lastname: Jones
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Focant
authors.forename: Chester
authors.initials: C
authors.lastname: Lapeza
authors.forename: Richard Y
authors.initials: RY
authors.lastname: Wang
authors.forename: Ernest E
authors.initials: EE
authors.lastname: McGahee
authors.forename: Yalin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wayman E
authors.initials: WE
authors.lastname: Turner
authors.forename: Bill
authors.initials: B
authors.lastname: Slazyk
authors.forename: Larry L
authors.initials: LL
authors.lastname: Needham
authors.forename: Donald G
authors.initials: DG
authors.lastname: Patterson
mesh_terms: D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood* / Q000266:history; D049673:History, 20th Century; D006801:Humans; D011075:Polybrominated Biphenyls / Q000097:blood* / Q000266:history; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000266:history; D012189:Retrospective Studies; D014481:United States
chemical_list: D004785:Environmental Pollutants; D011075:Polybrominated Biphenyls; D011078:Polychlorinated Biphenyls