title: Haematologial manifestations in HCV infected patients at Sharkia Governerate, Egypt.
abstract: Hepatitis C virus (HCV) is a major cause of morbidity worldwide. The aim of this study is to evaluate hematological manifestations occurring in patients suffering from chronic HCV infection. Positive HCV-RNA cases (109) were subjected to the following C.B.C., P.T., P.T.T., B.T., C.T., detection of F.D.Ps., measurement of plasma AAT then B.M. aspiration and examination for 20 cases of them. Patients were classified into 3 groups according to the histopathological staging and grading of liver biopsy. Comparison between groups according to histopathological grading and staging for hematological and chemical parameters revealed significant statistical difference in platelets count, S. Albumin, ALT and AST levels. Comparison between groups according to histopathological grading and staging for coagulation profile, AAT level and FDPs revealed significant statistical difference regarding all parameters. Bone marrow aspiration and examination revealed mild hypocellularity with increased number of lymphocytes and relevance of plasmacytoid-lymphocytes. From this study we can conclude that patients with chronic HCV infection are in need for good observation and follow up before taking therapy because they have some hematological abnormalities which need more concern in order to decrease their progressive effect before starting therapy for HCV per se. They should be always screened and given liver and marrow supportive supplements.
authors.affiliation: Faculty of Medicine, Zagazig University.
authors.forename: Seham
authors.initials: S
authors.lastname: Mahrous
authors.forename: Amal
authors.initials: A
authors.lastname: Abdel-Monem
authors.forename: Amal
authors.initials: A
authors.lastname: Mangoud
authors.forename: Mostafa
authors.initials: M
authors.lastname: Eissa
authors.forename: Essam
authors.initials: E
authors.lastname: Sabee
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Amin
authors.forename: Alaa
authors.initials: A
authors.lastname: Ismail
authors.forename: Tosson A
authors.initials: TA
authors.lastname: Morsy
authors.forename: Essam
authors.initials: E
authors.lastname: Nour Eldin
authors.forename: Yousry
authors.initials: Y
authors.lastname: Mostafa
authors.forename: Yousry
authors.initials: Y
authors.lastname: Abouel-Magd
authors.forename: Afefy F
authors.initials: AF
authors.lastname: Afefy
authors.forename: Eman
authors.initials: E
authors.lastname: el-Shorbagy
authors.forename: Mahmoud
authors.initials: M
authors.lastname: el-Sedawy
authors.forename: Hosnia
authors.initials: H
authors.lastname: Ragab
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hassan
authors.forename: Khalid
authors.initials: K
authors.lastname: Lakouz
authors.forename: Khalid
authors.initials: K
authors.lastname: Abdel-Aziz
authors.forename: Samah
authors.initials: S
authors.lastname: el-Saeed
authors.forename: Mona
authors.initials: M
authors.lastname: Abdel-Shafee
authors.forename: Lotfy
authors.initials: L
authors.lastname: el-Sayed
authors.forename: Nivin
authors.initials: N
authors.lastname: Salah
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D001780:Blood Coagulation Tests; D004906:Erythrocyte Count; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000473:pathology / Q000821:virology; D010976:Platelet Count; D012709:Serum Albumin / Q000032:analysis
chemical_list: D012709:Serum Albumin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase