title: Neuronal globus pallidus activity in patients with generalised dystonia.
abstract: We studied 516 globus pallidus neurons in dystonic patients. The firing rate was analysed. We classified the burst activity into tonic, burst, and pause patterns. Mean +/- SD firing rates and tonicity score for internal globus pallidus (GPi) and external globus pallidus (GPe) were 54.6 +/- 28.6; 58.01 +/- 39.1 and 1.18 +/- 0.55; 0.95 +/- 0.43, respectively. Differences in percentage appearance of tonic, burst, or paused neurons were not statistically significant for GPi versus GPe. GPi firing features in dystonic patients were closely similar to those of GPe. This could suggest that the abnormally patterned output from GPi would not result from increased differential inhibitory/excitatory input arising from the direct/indirect pathway but rather be transmitted from GPe, striatum, or either centromedian nucleus.
authors.affiliation: Movement Disorders Section, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina. mmerello@fleni.org.ar
authors.forename: Marcelo
authors.initials: M
authors.lastname: Merello
authors.forename: Daniel
authors.initials: D
authors.lastname: Cerquetti
authors.forename: Angel
authors.initials: A
authors.lastname: Cammarota
authors.forename: Eduardo
authors.initials: E
authors.lastname: Tenca
authors.forename: Carlos
authors.initials: C
authors.lastname: Artes
authors.forename: Julio
authors.initials: J
authors.lastname: Antico
authors.forename: Ramon
authors.initials: R
authors.lastname: Leiguarda
mesh_terms: D000293:Adolescent; D002648:Child; D004185:Disability Evaluation; D004421:Dystonia / Q000235:genetics / Q000503:physiopathology* / Q000601:surgery; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics; D009474:Neurons / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D018832:Molecular Chaperones; C108175:TOR1A protein, human