title: Safety and tolerability of extended-release venlafaxine in severe medical and surgical illness.
abstract: OBJECTIVE
  This study attempted to determine if extended-release venlafaxine is safe for use in severely medically and surgically ill depressed patients.
  
  
  METHODS
  The charts of 16 patients who were admitted to medical and surgical inpatient services and given extended-release venlafaxine were retrospectively evaluated for dose and duration of drug treatment, blood pressure changes, medication changes, and side effects.
  
  
  RESULTS
  There was 50%-75% improvement in depressive symptoms, with a statistically insignificant mean elevation in blood pressure.
  
  
  CONCLUSIONS
  Extended-release venlafaxine appears to be a safe and tolerable agent for the medical-surgical depressed inpatient.
authors.affiliation: Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA. schwartzresearch1@yahoo.com
authors.forename: Thomas
authors.initials: T
authors.lastname: Schwartz
authors.forename: Shefali
authors.initials: S
authors.lastname: Jindal
authors.forename: Subhdeep
authors.initials: S
authors.lastname: Virk
authors.forename: Michael
authors.initials: M
authors.lastname: Wade
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness / Q000523:psychology*; D003511:Cyclohexanols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000523:psychology*; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012720:Severity of Illness Index; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D003692:Delayed-Action Preparations; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride