Pulmonary resorption of inhaled gadobutrol in an animal model: usage to determine lung diffusion in MRI examinations.
The aim of this study was to examine a pulmonary gadobutrol resorption after inhalation. An examination of 16 young swine, which were given different amounts of gadobutrol through inhalation, was performed. A measurement of the signal elevation in peripheral lung tissue as well as in the thoracic aorta was made using a T(1)-weighted FLASH-3D sequence in a 1.5 T magnetic resonance imaging (MRI) machine. Twenty minutes after gadobutrol application, a steep signal elevation in the aorta was reported, as well as a plateau phase after 45 min. The signal elevation in peripheral lung tissue after inhalation increased to a mean of 33.9%. The concurrent signal elevation of the abdominal aorta was 137.4%. The evaluation of an intravascular signal elevation after gadobutrol inhalation opens the possibility to evaluate and obtain lung diffusion with MRI.
Hirsch
Wolfgang
W
Department of Diagnostic Radiology, University Hospital Leipzig, D-04103 Leipzig, Germany. w.hirsch@t-online.de
Wenkel
Ralph
R
Eichler
Gerburg
G
Paetzel
Martina
M
Schlüter
Andreas
A
D000280:Administration, Inhalation; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D005260:Female; D008168:Lung / Q000098:blood supply / Q000378:metabolism*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D023421:Models, Animal; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000378:metabolism*; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects; D013552:Swine; D013997:Time Factors
D009942:Organometallic Compounds; C090600:gadobutrol