title: Surveillance of drug-resistant childhood tuberculosis in Bangui, Central African Republic.
abstract: METHODS
  Bangui, the capital of the Central African Republic, where overall drug resistance and multidrug resistance among adult new tuberculosis (TB) cases were respectively 16.4% and 1.1% in 1998.
  
  
  OBJECTIVE
  To determine the prevalence of drug resistance among children with tuberculosis and to compare the epidemiological and clinical features of TB in children with drug-resistant and drug-susceptible TB.
  
  
  METHODS
  All strains of Mycobacterium tuberculosis obtained from children aged 0-15 years at Bangui Paediatric Hospital were prospectively collected from April 1998 to June 2000, and susceptibility testing was performed for each specimen. The children's epidemiological and clinical data were recorded.
  
  
  RESULTS
  Susceptibility results were available for 165/190 children with M. tuberculosis. Overall drug resistance and multidrug resistance were 15.2% and 0.6%, respectively. Isoniazid and streptomycin were the only drugs associated with TB monoresistance. No significant difference was found in the epidemiological or clinical data of children infected with a resistant strain and those infected with a susceptible strain.
  
  
  CONCLUSIONS
  The prevalence of drug resistance in childhood is similar to that observed in adult new TB cases in the same period. Surveillance will continue to be performed in Bangui periodically to assess the trend of true drug resistance among new TB cases.
authors.affiliation: Laboratoire des Mycobactéries, Institut Pasteur, Bangui, Central African Republic. kelembho_eric@yahoo.fr
authors.forename: E
authors.initials: E
authors.lastname: Kassa-Kelembho
authors.forename: G
authors.initials: G
authors.lastname: Bobossi-Serengbe
authors.forename: E C
authors.initials: EC
authors.lastname: Takeng
authors.forename: T B
authors.initials: TB
authors.lastname: Nambea-Koisse
authors.forename: F
authors.initials: F
authors.lastname: Yapou
authors.forename: A
authors.initials: A
authors.lastname: Talarmin
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000494:pharmacology; D002488:Central African Republic / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011159:Population Surveillance; D015995:Prevalence; D011446:Prospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission
chemical_list: D000995:Antitubercular Agents