title: Deoxypodophyllotoxin, a naturally occurring lignan, inhibits the passive cutaneous anaphylaxis reaction.
abstract: This study examined the effect of a podophyllotoxin derivative, deoxypodophyllotoxin (anthricin), which is a medicinal herb product isolated from Anthriscus sylvestris Hoffm. Deoxypodophyllotoxin was tested in a rat PCA (passive cutaneous anaphylaxis) assay by administering deoxypodophyllotoxin intraperitoneally (1.0 to 10 mg/kg, i.p.) and intravenously (0.25 to 1.0 mg/kg, i.v.). Deoxypodophyllotoxin dose-dependently inhibited the PCA reaction activated by anti-dinitrophenyl (DNP) IgE. The PCA inhibitory activity of deoxypodophyllotoxin was stronger than those of prednisolone and indomethacin, which were used as positive controls. These results suggest that deoxypodophyllotoxin may be beneficial in regulating the immediate-type allergic reaction.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, Korea.
authors.forename: Chang Xiu
authors.initials: CX
authors.lastname: Lin
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Son
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Ju
authors.forename: Tae Chul
authors.initials: TC
authors.lastname: Moon
authors.forename: Eunkyung
authors.initials: E
authors.lastname: Lee
authors.forename: So Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Mi-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jong Keun
authors.initials: JK
authors.lastname: Son
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Hyeun Wook
authors.initials: HW
authors.lastname: Chang
mesh_terms: D000818:Animals; D019661:Apiaceae; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D006969:Hypersensitivity, Immediate / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D017705:Lignans / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D011034:Podophyllotoxin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans; D010936:Plant Extracts; C014451:deoxypodophyllotoxin; D011034:Podophyllotoxin