title: Combinatorial synthesis of substituted biaryls and heterocyclic arylamines.
abstract: In this paper, we report very general conditions that enable palladium-mediated coupling reactions on the solid support. A wide variety of biaryls and arylamines (including pyrimidines) have been synthesized using this protocol. The chemistry facilitates a combinatorial approach to the production of large numbers of medicinally relevant heterocyclic structures.
authors.affiliation: NeoGenesis Pharmaceuticals, Inc., 840 Memorial Drive, Cambridge, Massachusetts 02139, USA. yaoma@neogenesis.com
authors.forename: Yao
authors.initials: Y
authors.lastname: Ma
authors.forename: Laura
authors.initials: L
authors.lastname: Margarida
authors.forename: Jeseca
authors.initials: J
authors.lastname: Brookes
authors.forename: Gergely M
authors.initials: GM
authors.lastname: Makara
authors.forename: Scott C
authors.initials: SC
authors.lastname: Berk