Selectivity in the oligomerisation of G protein-coupled receptors.
G protein-coupled receptors can exist as dimers and/or higher order oligomers. Such quaternary structure appears central to their plasma membrane delivery and, potentially, to function. Recent evidence that these receptors can form hetero- as well as homo-dimers/oligomers has significant implications for pharmacology and pathophysiology. Knowledge of the basis and selectivity of GPCR hetero-dimerisation is thus vital. Current understanding of these areas is reviewed.
Milligan
Graeme
G
Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. g.milligan@bio.gla.ac.uk
Lopez-Gimenez
Juan
J
Wilson
Shirley
S
Carrillo
Juan J
JJ
D000818:Animals; D019281:Dimerization; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D020836:Protein Structure, Quaternary; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*
D008024:Ligands; D043562:Receptors, G-Protein-Coupled