title: e6a2 BCR-ABL transcript in chronic myeloid leukemia: is it associated with aggressive disease?
abstract: We describe the fourth case of e6a2 BCR-ABL transcript in a patient with chronic myeloid leukemia (CML), using reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing analysis. The clinical and hematologic features and the aggressive course of disease in our patient and in the others reported in literature lead us to hypothesize that this atypical rearrangement may be associated with a worse prognosis.
authors.forename: Simona
authors.initials: S
authors.lastname: Colla
authors.forename: Gabriella
authors.initials: G
authors.lastname: Sammarelli
authors.forename: Simone
authors.initials: S
authors.lastname: Voltolini
authors.forename: Monica
authors.initials: M
authors.lastname: Crugnola
authors.forename: Paola
authors.initials: P
authors.lastname: Sebastio
authors.forename: Nicola
authors.initials: N
authors.lastname: Giuliani
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018450:Disease Progression; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D016898:Interferon-alpha; D016044:Fusion Proteins, bcr-abl; D006918:Hydroxyurea