title: Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome.
abstract: : The authors describe a 15-year-old girl presenting with a cerebral ischemic stroke as the first manifestation of catastrophic antiphospholipid antibody syndrome secondary to acute myeloid leukemia (AML). Despite treatment with anticoagulants, therapeutic plasma exchange, and chemotherapy, the patient developed multiorgan thromboses and failure, eventually culminating in death. This unusual presentation of AML has not been previously described in children. Clinical features of antiphospholipid antibody syndrome and current knowledge regarding its association with malignancies are reviewed.
authors.affiliation: Division of Rheumatology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Angela
authors.initials: A
authors.lastname: Orsino
authors.forename: Rayfel
authors.initials: R
authors.lastname: Schneider
authors.forename: Gabrielle
authors.initials: G
authors.lastname: DeVeber
authors.forename: Ronald
authors.initials: R
authors.lastname: Grant
authors.forename: Patricia
authors.initials: P
authors.lastname: Massicotte
authors.forename: Patricia
authors.initials: P
authors.lastname: Canning
authors.forename: Manuel
authors.initials: M
authors.lastname: Carcao
mesh_terms: D000293:Adolescent; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000209:etiology*; D002388:Catastrophic Illness; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000175:diagnosis*; D020521:Stroke / Q000209:etiology; D013927:Thrombosis / Q000209:etiology; D017211:Treatment Failure
chemical_list: D017152:Antibodies, Antiphospholipid