title: Oral solid form of primary effusion lymphoma mimicking plasmablastic lymphoma.
abstract: Primary effusion lymphoma (PEL) is a rare large cell lymphoma subtype that usually is associated with human immunodeficiency virus infection. Features facilitating PEL identification are its clinical presentation, cytologic findings, immunophenotypic profile, and particularly, relation to human herpesvirus 8 (HHV8) infection. Uncommonly, PEL may present as a solid form that predominantly involves the distal digestive tract and poses major diagnostic problems, especially when unassociated with body cavity effusions. We herein report the case of an HIV-positive 42-year-old male with synchronous presentation of a pleural cavity PEL and a tongue-based lesion, both displaying plasmablastic features. Demonstration of HHV8 presence in the lingual lesion excluded a plasmablastic lymphoma and established the diagnosis of an oral solid form of PEL. This case illustrates the need for investigating HHV8 in any plasmablastic-looking lymphoma, especially in HIV-infected patients.
authors.affiliation: Department of Pathology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Mate
authors.forename: José-Tomás
authors.initials: JT
authors.lastname: Navarro
authors.forename: Aurelio
authors.initials: A
authors.lastname: Ariza
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Ribera
authors.forename: Eva
authors.initials: E
authors.lastname: Castellà
authors.forename: Jordi
authors.initials: J
authors.lastname: Juncà
authors.forename: Cristina
authors.initials: C
authors.lastname: Tural
authors.forename: José-Francisco
authors.initials: JF
authors.lastname: Nomdedeu
authors.forename: Beatriz
authors.initials: B
authors.lastname: Bellosillo
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
authors.forename: Isabel
authors.initials: I
authors.lastname: Granada
authors.forename: Fuensanta
authors.initials: F
authors.lastname: Millá
authors.forename: Evarist
authors.initials: E
authors.lastname: Feliu
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D005434:Flow Cytometry; D015658:HIV Infections; D006566:Herpesviridae Infections / Q000473:pathology*; D019288:Herpesvirus 8, Human; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D016483:Lymphoma, AIDS-Related / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008297:Male; D009062:Mouth Neoplasms / Q000150:complications / Q000235:genetics / Q000473:pathology*; D010996:Pleural Effusion / Q000209:etiology; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000473:pathology*