title: Management of seizures in children with falciparum malaria.
abstract: Falciparum malaria is the most common cause of convulsions in children admitted to hospital in malaria endemic areas. Detection of convulsions requires close monitoring and one should be on the look out for signs of subtle convulsions. About a third of acute seizures in children with cerebral malaria, do not manifest as convulsions, but as changes in eye deviation, salivation and/or eye deviation. It is important to terminate convulsions lasting more than 5 min, since prolonged convulsions are associated with neurological deficits in survivors of children with severe malaria. Initial management should include putting the child into the left lateral position, checking the blood glucose and administering oxygen if hypoxic. The benzodiazepines, particularly diazepam, are used as the initial anticonvulsants. Phenobarbital and phenytoin are used as second-line treatments. Prompt and effective management of falciparum malaria associated convulsions may contribute to a better outcome in children with severe malaria.
authors.affiliation: Walter Reed Project-Centre for Clinical Research, Kenya Medical Research Institute [KEMRI], PO Box 54, Kisumu. bogutu@kisian.mimcom.net
authors.forename: B R
authors.initials: BR
authors.lastname: Ogutu
authors.forename: C R J C
authors.initials: CR
authors.lastname: Newton
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D003975:Diazepam / Q000627:therapeutic use; D004638:Emergency Treatment; D006801:Humans; D016779:Malaria, Cerebral / Q000628:therapy; D016778:Malaria, Falciparum / Q000150:complications*; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000209:etiology* / Q000628:therapy*
chemical_list: D000927:Anticonvulsants; D010672:Phenytoin; D003975:Diazepam; D010634:Phenobarbital