title: Properties of mixed alkanethiol-dendrimer layers and their applications in biosensing.
abstract: We studied the properties of mixed alkanethiol-dendrimer layers on a gold support and their application in biosensing. We showed that properties of glucose sensor can be modified using a different ratio of 1-hexadecanethiol (HDT) and poly(amidoamine) dendrimer of first generation (G1). The cyclic voltammetry in the presence of the redox couple, Fe(CN)(6)(3-)/Fe(CN)(6)(4-), was used for estimating how effectively the layer blocks the redox probe's access to the electrode surface. A scanning electrochemical microscope (SECM) was used to image the resulting distribution of the organic compounds. We found that with increasing content of dendrimers, the integrity of the layers was improved.
authors.affiliation: Institute of Animal Biochemistry and Genetics, Slovak Academy of Sciences, 900 28 Ivanka pri Dunaji, Slovak Republic.
authors.forename: L
authors.initials: L
authors.lastname: Svobodová
authors.forename: M
authors.initials: M
authors.lastname: Snejdárková
authors.forename: K
authors.initials: K
authors.lastname: Tóth
authors.forename: R E
authors.initials: RE
authors.lastname: Gyurcsanyi
authors.forename: T
authors.initials: T
authors.lastname: Hianik
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D020099:Coated Materials, Biocompatible / Q000032:analysis / Q000138:chemical synthesis; D003460:Crystallization / Q000379:methods; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods; D004800:Enzymes, Immobilized / Q000032:analysis / Q000737:chemistry; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005947:Glucose / Q000032:analysis* / Q000737:chemistry; D005949:Glucose Oxidase / Q000032:analysis* / Q000737:chemistry* / Q000648:ultrastructure; D011073:Polyamines / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D004800:Enzymes, Immobilized; D011073:Polyamines; D011108:Polymers; D013438:Sulfhydryl Compounds; C086974:hexadecanethiol; D005949:Glucose Oxidase; D005947:Glucose