Allelic loss during progression of follicular lymphoma.
We performed loss of heterozygosity (LOH) analysis on matched lymph nodes before and after progression of follicular lymphoma (FL), and found novel LOH on chromosome arm 12p. This LOH has not been previously reported in association with FL transformation. Other sites of frequent LOH include chromosome arms 6q and 9p. LOH was observed in both transformed FL and relapse FL. These data suggest that altered tumor suppressor genes exist on 6q, 9p, and 12p that have an important role in the progression of FL. Genetic changes accumulated in relapsed FL in the absence of histological changes compared to initial diagnosis.
Takeuchi
Seisho
S
Department of Medicine, Kochi University, Okohcho, Nankoku, Kochi 783-8505, Japan. takeuti@kochi-ms.ac.jp
de Vos
Sven
S
Takeuchi
Naoko
N
Fermin
Anthony C
AC
Grogan
Thomas M
TM
Seo
Hiromi
H
Said
Jonathan W
JW
Koeffler
H Phillip
HP
D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D018450:Disease Progression; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D018895:Microsatellite Repeats; D009364:Neoplasm Recurrence, Local / Q000235:genetics