title: Subacute sclerosing panencephalitis with fulminating course: follow-up magnetic resonance spectroscopy (MRS) findings.
abstract: The fulminating form of subacute sclerosing panencephalitis is an extremely rare condition. Imaging findings are usually not correlated with clinical staging. We describe a 4-year-old girl with severe neuronal loss, demyelination, and gliosis in subcortical white matter by magnetic resonance spectroscopic examination even though she was diagnosed as clinical stage II. In 2 months' time, her clinical status worsened significantly. Follow-up magnetic resonance spectroscopy revealed findings that were consistent with clinical status. It is our opinion that magnetic resonance spectroscopy could demonstrate a rapidly progressive fulminating course of subacute sclerosing panencephalitis even in the early clinical stages.
authors.affiliation: Department of Radiology, Inonu University School of Medicine, Turgut Ozal Medical Center, Malatya, Turkey. aalkan@inonu.edu.tr
authors.forename: Alpay
authors.initials: A
authors.lastname: Alkan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Kutlu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Sigirci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Kaya
authors.initials: K
authors.lastname: Sarac
authors.forename: Cengiz
authors.initials: C
authors.lastname: Yakinci
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D002675:Child, Preschool; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003937:Diagnosis, Differential; D018450:Disease Progression; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005911:Gliosis / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D007294:Inositol / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009186:Myelin Sheath / Q000473:pathology; D009460:Neurologic Examination; D009474:Neurons / Q000473:pathology; D013344:Subacute Sclerosing Panencephalitis / Q000175:diagnosis*
chemical_list: D001224:Aspartic Acid; D007294:Inositol; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline