[Necessity and usefulness of bioinformatic methods for microarray data analysis].
Data emerging from DNA microarray experiments are usually difficult to interpret. While the level of expression of several thousand genes can be measured in a single experiment, only a few dozen experiments are normally carried out, leading to data sets of very high dimensionality and low cardinality. The computational analysis of gene expression data makes significant usage of machine learning and statistical methods. Nevertheless, caution should be used in the blind adoption of these methods, as this usually leads to an over-interpretation of the expression profiles. The following presentation provides an overview of up-to-date principles of biostatistical analysis. A potential application for the analysis of high-dimensional expression profiles of prostate cancer is given.
Kestler
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Abteilung Neuroinformatik, Universität Ulm. hans.kestler@medizin.uni-ulm.de
Küfer
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D002869:Chromosome Aberrations; D019295:Computational Biology; D005103:Expert Systems; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D008297:Male; D016571:Neural Networks, Computer; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology