title: [Synthesis of (+/-) ibuprofen sugar derivatives].
abstract: OBJECTIVE
  (+/-) Ibuprofen sugar derivatives were prepared in order to decrease side-effects and increase bioavailability of (+/-) ibuprofen.
  
  
  METHODS
  The synthesis of derivatives were performed using 1,2:3, 4-di-O-isopropylidene-beta-D-galactopyranose, 1,3,4,5-tetra-O-acetyl-2-deoxy-2-amino-beta-D-gluctopyranose, 3,4 6-tri-O-acetyl-2-deoxy-2-N-acetyl-beta-D-gluctosylamine and 2,3,6,2',3',4',6'-hepta-O-acetyl-beta-D-lactosylamine as glycosyl donors, respectively. Target products (4, 7, 12a, 12b, 13) were obtained after deprotection.
  
  
  RESULTS
  Five compounds (4, 7, 12a, 12b, 13) were synthesized as new compounds. The structures of all objective compounds were confirmed by 1HNMR, 13CNMR, HMQC, COSY, IR and MS.
  
  
  CONCLUSIONS
  It was found that 12a showed better anti-inflammatory activity than (+/-) ibuprofen.
authors.affiliation: Institute of Marine Drugs, Ocean University of China, Qingdao 266003, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Song
authors.forename: Ying-xia
authors.initials: YX
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Sun
authors.forename: Feng
authors.initials: F
authors.lastname: Qu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D011897:Random Allocation
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen