Differences in spermatogenesis in cryptorchid testes among various strains of mice.
The purpose of the study reported here was to define strain differences in spermatogenesis in cryptorchid testes in mice. Mice of strains A/J, BALB/c, CBA/N, C3H/He, C57BL/6 (B6), ddY and ICR were found to be sensitive to heat stress attributable to experimentally induced cryptorchidism. In contrast, mice of strains AKR/N (AKR), MRL/MpJ-+/+ (M+) and MRL/MpJ-lpr/lpr (lpr) were resistant to heat stress. Relative increases of apoptotic cells were detected in the sensitive group, but not in the resistant group. A decrease of proliferating cell nuclear antigen-immunoreactive cells after experimentally induced cryptorchidism was observed only in the sensitive group. These results suggested that heat stress-resistant germ cells were present in MRL and AKR strains, possibly originating from the genetic background.
Kazusa
Katsuyuki
K
Laboratory of Experimental Animal Science, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Namiki
Yuka
Y
Asano
Atsushi
A
Kon
Yasuhiro
Y
Endoh
Daiji
D
Agui
Takashi
T
D000818:Animals; D017209:Apoptosis; D003456:Cryptorchidism / Q000503:physiopathology*; D006358:Hot Temperature; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D013045:Species Specificity; D013091:Spermatogenesis; D013737:Testis / Q000166:cytology / Q000473:pathology / Q000503:physiopathology*