title: Plastic changes of motor network after constraint-induced movement therapy.
abstract: The effects of short-term constraint-induced movement (CIM) therapy on the activation of the motor network were investigated with functional magnetic resonance imaging (fMRI). Movement of the less-affected arms of five patients was restricted and intensive training of the affected upper limb was performed. Functional MRI was acquired before and after two-weeks of CIM therapy. All patients showed significant improvement of motor function in their paretic limbs after CIM therapy. For three patients, new activation in the contralateral motor/premotor cortices was observed after CIM therapy. Increased activation of the ipsilateral motor cortex and SMA was observed in the other patient. Our results demonstrated that plastic changes of the motor network occurred as a neural basis of the improvement subsequent to CIM therapy following brain injury.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Ilwon-dong, Kangnam-gu, Seoul 135-710, Korea. yunkim@smc.samsung.co.kr
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Ji-Won
authors.initials: JW
authors.lastname: Park
authors.forename: Myoung-Hwan
authors.initials: MH
authors.lastname: Ko
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Jang
authors.forename: Peter K W
authors.initials: PK
authors.lastname: Lee
mesh_terms: D000328:Adult; D006801:Humans; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009068:Movement; D009473:Neuronal Plasticity; D026741:Physical Therapy Modalities; D020521:Stroke / Q000503:physiopathology / Q000628:therapy*; D000071939:Stroke Rehabilitation