DNA detection by integrable electronics.
This paper presents a new electronic methodology to detect DNA hybridization for rapid identification of diseases, as well as food and environmental monitoring on a genetic base. The proposed solution exploits a new (electrical) capacitive measurement circuit, not requiring any prior labeling of the DNA (as it is often the case with the commonly employed optical detection). The sensitivity, the reliability, and the reproducibility of this device have been evaluated by experiments performed with a (non-integrated) prototype implementation, easily integrable in IC and/or micro-fabricated lab-on-a-chip.
Guiducci
C
C
DEIS, University of Bologna, Bologna, Italy. cguiducci@deis.unibo.it
Stagni
C
C
Zuccheri
G
G
Bogliolo
A
A
Benini
L
L
Samorì
B
B
Riccò
B
B
D000327:Adsorption; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D015342:DNA Probes / Q000737:chemistry*; D025802:Electric Capacitance; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D004582:Electronics, Medical; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D008904:Miniaturization; D020411:Oligonucleotide Array Sequence Analysis / Q000295:instrumentation* / Q000379:methods; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018511:Systems Integration
D020099:Coated Materials, Biocompatible; D015342:DNA Probes; D004247:DNA