Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride.
An efficient method for the synthesis of phosphorylated prodrugs is described. The preparation of various bis-pivaloyloxymethyl (POM) phosphate triesters was accomplished in moderate to good yields with the use of bis(POM) phosphoryl chloride under mild conditions.
Hwang
Yousang
Y
Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N. Wolfe St. Baltimore, Maryland 21205, USA.
Cole
Philip A
PA
D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010421:Pentanoic Acids / Q000737:chemistry*; D010766:Phosphorylation; D011355:Prodrugs / Q000138:chemical synthesis*
D009943:Organophosphorus Compounds; D010421:Pentanoic Acids; D011355:Prodrugs; C494260:bis-pivaloyloxymethyl phosphate