Clinical ototoxicity of teicoplanin.
No strong evidence of ototoxicity of teicoplanin can be found in the literature, possibly because of conservative definitions of ototoxicity. We performed audiometry over time to compare the ototoxicity of teicoplanin with that of cloxacillin as a non-ototoxic standard. The data were analyzed with a linear mixed-effects model. The hearing thresholds of 12 patients who were treated with teicoplanin for severe staphylococcal infections showed a slight but significant increase over time, whereas the thresholds of 5 patients treated with cloxacillin decreased significantly during treatment. This improvement in hearing with cloxacillin may be attributed to improvement of the clinical condition. This outcome implies that previous reports that suggest a lack of ototoxicity of teicoplanin potentially underestimate the risk and should be interpreted accordingly.
Bonnet
Raymond M
RM
Department of Ear, Nose, and Throat Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Mattie
Herman
H
de Laat
Jan A P M
JA
Schoemaker
Hendrik C
HC
Frijns
Johan H M
JH
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001301:Audiometry, Pure-Tone; D003023:Cloxacillin / Q000009:adverse effects* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D006309:Hearing / Q000187:drug effects; D034381:Hearing Loss / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D016014:Linear Models; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy*; D017334:Teicoplanin / Q000009:adverse effects* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D003023:Cloxacillin