Effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.
OBJECTIVE
To investigate the effects of bile reflux and intragastric microflora changes on lesions of remnant gastric mucosa after gastric operation.


METHODS
Concentration of bile acid and total bacterial counts (TBC) in gastric juice were measured in 49 patients with peptic ulcer before and after gastrectomy. One year after the operation, sample of gastric mucosa taken from all the patients were used for histological examination.


RESULTS
The concentration of gastric bile acid was significantly increased in group B-I, or B-II and SV+A than that in group HSV (P<0.05-0.01). The abnormal histological changes in the remnant gastric mucosa were more common in the first 2 groups than in the last group.


CONCLUSIONS
The type of gastrectomy can affect bile reflux. The abnormal histological changes in the remnant gastric mucosa are closely related to the elevation of bile acid concentration and increase of TBC in gastric juice. HSV can effectively prevent bile reflux and keep the gastric physiological functions stable.
Zhang
Chao
C
Department of General Surgery, Southwest Hospital, Third Military Medical University, Gaotan Yan, Chongqing 400038, China. meizhang6688@yahoo.com
Liu
Zhan-Kui
ZK
Yu
Pei-Wu
PW
D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis; D001655:Bile Reflux; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D005750:Gastric Juice / Q000737:chemistry / Q000382:microbiology; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D011178:Postgastrectomy Syndromes; D013276:Stomach Ulcer / Q000601:surgery
D001647:Bile Acids and Salts