HLA class I allele distribution of a Hong Kong Chinese population based on high-resolution PCR-SSOP typing.
A stem cell registry population from Hong Kong, of Chinese ethnicity, was examined for HLA-A and HLA-B alleles using a two-stage sequence-specific oligonucleotide probe system. Comparison of the HLA-A and HLA-B frequencies with different populations showed a close relationship with a Chinese population from Singapore, although there were several differences in the presence/absence of alleles at the HLA-B locus. Having the data available on these registry donors will influence the search strategy and the ongoing compilation of new donors to the registry. In addition, knowing which alleles do/do not occur in this population will aid in the distinction of ambiguities which result from the use of many of the typing kits available.
Middleton
D
D
Northern Ireland Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, UK. derek.middleton@bll.n-i.nhs.uk
Hawkins
B R
BR
Williams
F
F
Meenagh
A
A
Moscoso
J
J
Zamora
J
J
Arnaiz-Villena
A
A
D000483:Alleles; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006723:Hong Kong / Q000453:epidemiology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction
D015395:Histocompatibility Antigens Class I