title: Acute left prefrontal transcranial magnetic stimulation in depressed patients is associated with immediately increased activity in prefrontal cortical as well as subcortical regions.
abstract: BACKGROUND
  Focal prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) was originally investigated as a potential antidepressant under the assumption that in depressed patients, prefrontal cortex stimulation would produce changes in connected limbic regions involved in mood regulation.
  
  
  METHODS
  Fourteen adult patients with depression were scanned in a 1.5-T scanner using interleaved rTMS (1 Hz) applied on the left prefrontal cortex over 7.35 min. Images were analyzed with Statistical Parametric Mapping 2b and principal component analysis.
  
  
  RESULTS
  Over the left prefrontal cortex, 1-Hz TMS was associated with increased activity at the site of stimulation as well as in connected limbic regions: bilateral middle prefrontal cortex, right orbital frontal cortex, left hippocampus, mediodorsal nucleus of the thalamus, bilateral putamen, pulvinar, and insula (t = 3.85, p <.001). Significant deactivation was found in the right ventromedial frontal cortex.
  
  
  CONCLUSIONS
  In depressed patients, 1-Hz TMS at 100% motor threshold over the left prefrontal cortex induces activation underneath the coil, activates frontal-subcortical neuronal circuits, and decreases activity in the right ventromedial cortex. Further work is needed to understand whether these immediate changes vary as a function of TMS use parameters (intensity, frequency, location) and whether they relate to neurobiologic effects and antidepressant mechanisms of TMS.
authors.affiliation: Brain Stimulation Laboratory, Department of Psychiatry, Charleston, South Carolina 29425, USA.
authors.forename: Xingbao
authors.initials: X
authors.lastname: Li
authors.forename: Ziad
authors.initials: Z
authors.lastname: Nahas
authors.forename: F Andrew
authors.initials: FA
authors.lastname: Kozel
authors.forename: Berry
authors.initials: B
authors.lastname: Anderson
authors.forename: Daryl E
authors.initials: DE
authors.lastname: Bohning
authors.forename: Mark S
authors.initials: MS
authors.lastname: George
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism* / Q000628:therapy*; D001921:Brain / Q000378:metabolism; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000378:metabolism* / Q000628:therapy*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000378:metabolism*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation / Q000295:instrumentation*
chemical_list: D000928:Antidepressive Agents