title: Frequency of reduced vancomycin susceptibility and heterogeneous subpopulation in persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia.
abstract: Vancomycin susceptibility was checked in isolates from initial and final blood samples obtained from 22 patients with persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia. The minimum inhibitory concentration of vancomycin was determined using Etest and found to have increased in 2 pairs of isolates, and results of screening in 4 mu g vancomycin and a modified population analysis profile suggested heteroresistance in 3 isolates (13.6%). Heteroresistance is not a common cause of persistent or recurrent bacteremia.
authors.affiliation: Section of Infectious Diseases, Department of Medicine, St. John Hospital and Medical Center, Detroit, Michigan 48236, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Khosrovaneh
authors.forename: Kathleen
authors.initials: K
authors.lastname: Riederer
authors.forename: Sajjad
authors.initials: S
authors.lastname: Saeed
authors.forename: M Shamse
authors.initials: MS
authors.lastname: Tabriz
authors.forename: Amar R
authors.initials: AR
authors.lastname: Shah
authors.forename: Michel M
authors.initials: MM
authors.lastname: Hanna
authors.forename: Mamta
authors.initials: M
authors.lastname: Sharma
authors.forename: Leonard B
authors.initials: LB
authors.lastname: Johnson
authors.forename: Mohammad G
authors.initials: MG
authors.lastname: Fakih
authors.forename: Riad
authors.initials: R
authors.lastname: Khatib
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D018432:Drug Resistance, Multiple; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin