Diterpenes from the leaves of Croton zambesicus.
Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.
Block
Sebastien
S
Laboratoire de Pharmacognosie, Unité CHAM, Université Catholique de Louvain, UCL 72.30-CHAM, Av. E. Mounier, 72, 1200 Bruxelles, Belgium.
Baccelli
Chiara
C
Tinant
Bernard
B
Van Meervelt
Luc
L
Rozenberg
Raoul
R
Habib Jiwan
Jean-Louis
JL
Llabrès
Gabriel
G
De Pauw-Gillet
Marie-Claire
MC
Quetin-Leclercq
Joelle
J
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D029802:Croton / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes