A PNA4 quadruplex.
A tetrameric PNA, TGGG, has been shown to form an intermolecular G-quadruplex. Nanoelectrospray mass spectrometry, combined with solution-phase H/D exchange, established formation of a specific tetramolecular complex. UV melting studies show that this complex undergoes a quadruplex melting transition. This is a novel four-stranded structure that offers the gross structural features of a DNA quadruplex, but without the negatively charged backbone.
Krishnan-Ghosh
Yamuna
Y
University Chemical Laboratories, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
Stephens
Elaine
E
Balasubramanian
Shankar
S
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D017666:Deuterium Oxide; D005612:Freeze Drying; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D008968:Molecular Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D014466:Ultraviolet Rays
D007202:Indicators and Reagents; D020135:Peptide Nucleic Acids; D017666:Deuterium Oxide