Whole-brain vascular reactivity measured by fMRI using hyperventilation and breath-holding tasks: efficacy of 3D prospective acquisition correction (3D-PACE) for head motion.
Functional MR imaging (fMRI) study using hyperventilation and breath-holding task has been reported to be one of the non-invasive methods to examine whole-brain vascular reactivity. The purpose of this study was to evaluate the efficacy of a method for 3D prospective detection and correction of head motion (3D-PACE) in a study of whole-brain vascular reactivity using hyperventilation and breath-holding tasks. Eight healthy volunteers were scanned using an fMRI protocol of hyperventilation and breath-holding task blocks at 3 T in separate runs with and without 3D-PACE. In two subjects, two more runs with and without 3D-PACE were repeated. The mean total number of activated voxels +/- standard deviation was 26,405.3+/-1,822.2 in the run with 3D-PACE and 17,329.9+/-2,766.3 in the run without 3D-PACE ( P<0.05), although there is some intersubject variation regarding the effect of 3D-PACE. In the two subjects whose performed two more runs, the number of activated voxels were smaller in the run without 3D-PACE than even in the run with 3D-PACE performed later. We conclude that 3D-PACE is beneficial for fMRI studies of whole-brain vascular reactivity induced by hyperventilation and breath-holding.
Naganawa
Shinji
S
Department of Radiology, Nagoya University School of Medicine, 65 Tsurumai-cho, Shouwa-ku, 466-8550 Nagoya, Japan. naganawa@med.nagoya-u.ac.jp
Koshikawa
Tokiko
T
Fukatsu
Hiroshi
H
Ishigaki
Takeo
T
Maruyama
Katsuya
K
Takizawa
Osamu
O
D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D019416:Head Movements / Q000502:physiology*; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results; D012119:Respiration