title: Global burden of depressive disorders in the year 2000.
abstract: BACKGROUND
  The initial Global Burden of Disease study found that depression was the fourth leading cause of disease burden, accounting for 3.7% of total disability adjusted life years (DALYs) in the world in 1990.
  
  
  OBJECTIVE
  To present the new estimates of depression burden for the year 2000.
  
  
  METHODS
  DALYs for depressive disorders in each world region were calculated, based on new estimates of mortality, prevalence, incidence, average age at onset, duration and disability severity.
  
  
  RESULTS
  Depression is the fourth leading cause of disease burden, accounting for 4.4% of total DALYs in the year 2000, and it causes the largest amount of non-fatal burden, accounting for almost 12% of all total years lived with disability worldwide.
  
  
  CONCLUSIONS
  These data on the burden of depression worldwide represent a major public health problem that affects patients and society.
authors.affiliation: Global Programme on Evidence for Health Policy, WHO, Geneva, Switzerland. ustunb@who.int
authors.forename: T B
authors.initials: TB
authors.lastname: Ustün
authors.forename: J L
authors.initials: JL
authors.lastname: Ayuso-Mateos
authors.forename: S
authors.initials: S
authors.lastname: Chatterji
authors.forename: C
authors.initials: C
authors.lastname: Mathers
authors.forename: C J L
authors.initials: CJ
authors.lastname: Murray
mesh_terms: D000328:Adult; D017281:Cost of Illness; D003866:Depressive Disorder / Q000453:epidemiology*; D004185:Disability Evaluation; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D008297:Male; D015995:Prevalence; D011634:Public Health; D019057:Quality-Adjusted Life Years