Anemia of inflammation: the cytokine-hepcidin link.
The anemia of inflammation, commonly observed in patients with chronic infections, malignancy, trauma, and inflammatory disorders, is a well-known clinical entity. Until recently, we understood little about its pathogenesis. It now appears that the inflammatory cytokine IL-6 induces production of hepcidin, an iron-regulatory hormone that may be responsible for most or all of the features of this disorder.
Andrews
Nancy C
NC
Children's Hospital, Howard Hughes Medical Institute, Harvard Medical School, and Dana-Farber Cancer Institute, Boston, Massachusetts 02115-5737, USA. nandrews@enders.tch.harvard.edu
D000740:Anemia / Q000209:etiology*; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000096:biosynthesis*; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism* / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008954:Models, Biological
D023181:Antimicrobial Cationic Peptides; D016207:Cytokines; C578702:HAMP protein, human; C579599:Hamp protein, mouse; D064451:Hepcidins; D015850:Interleukin-6; D007501:Iron