Profound insights into squalene cyclization.
In this issue of Chemistry & Biology, our understanding of the formation of pentacyclic hopene from the linear squalene is enhanced by an X-ray structure of a complex between squalene-hopene cyclase and the substrate analog 2-azasqualene.
Poralla
Karl
K
Institut für Mikrobiologie, Eberhardt-Karls-Universität Tübingen, Germany.
D018360:Crystallography, X-Ray; D003500:Cyclization; D019751:Intramolecular Transferases / Q000737:chemistry / Q000378:metabolism; D008956:Models, Chemical; D015394:Molecular Structure; D013185:Squalene / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism; D014315:Triterpenes / Q000138:chemical synthesis
C491033:2-azasqualene; D014315:Triterpenes; C028765:diploptene; D013185:Squalene; D019751:Intramolecular Transferases; C066630:squalene-hopene cyclase