title: Amino acid uptake in arterio-venous serum of normal and cancerous colon tissues.
abstract: OBJECTIVE
  To investigate the difference of amino acid uptake between normal and cancerous colon tissues.
  
  
  METHODS
  Sixteen patients with colon cancer were enrolled in our study. Blood samples were taken during operations, serum amino acid concentrations of blood from cancerous or normal colon were analyzed. Amino acid uptake rate was calculated by the A-V difference and evaluated statistically.
  
  
  RESULTS
  Except for methionine, the uptake rate of amino acids in cancer was higher than that in normal colon (25.01% vs -2.29%, P<0.01). The amino acid uptake rate did not correlate to the size of tumor mass (P>0.05). There was no statistical significance in the amino acid uptake rate according to the Dukes stage, though it was higher in patients with Dukes stage C or D than that with Dukes stage B (P>0.05).
  
  
  CONCLUSIONS
  Abnormal synthetic metabolism of colon cancer may contribute to its higher amino acid uptake rate than that of normal colon.
authors.affiliation: Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, Zhejiang Province, China. wanglinbo@medmail.com.cn
authors.forename: Lin-Bo
authors.initials: LB
authors.lastname: Wang
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Shen
authors.forename: Su-Zhan
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Ke-Feng
authors.initials: KF
authors.lastname: Ding
authors.forename: Shu
authors.initials: S
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D001158:Arteries / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D003106:Colon / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D044967:Serum / Q000737:chemistry*; D014680:Veins / Q000378:metabolism
chemical_list: D000596:Amino Acids