title: The relationship between salivary secretion rate and masticatory efficiency.
abstract: In order to elucidate the relationship between the salivary secretion rate and masticatory efficiency, experimental hypo- and hyper-salivation were produced by the administration of atropine sulphate presenting an anticholinergic effect and pilocarpine hydrochloride having a muscarine effect orally in 10 healthy fully dentates. To confirm the pharmaceutical effect of these drugs, the unstimulated whole salivary secretion rate during 10 min, and masticatory efficiency using the sieve method were measured before and after medication. The unstimulated whole salivary secretion rate during 10 min decreased significantly by the administration of atropine sulphate (P < 0.05), and increased significantly by pilocarpine hydrochloride (P < 0.01). The masticatory efficiency after atropine sulphate medication was significantly lower than that before (P < 0.01). The increase in salivary secretion by pilocarpine hydrochloride did not lead to a higher masticatory efficiency. The evidence supports the understanding that saliva plays an important role in masticatory function.
authors.affiliation: Department of Removable Prosthodontics, Health Sciences University of Hokkaido School of Dentistry, Ishikari-Tobetsu, Hokkaido, Japan. ishijima@hoku-iryo-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ishijima
authors.forename: H
authors.initials: H
authors.lastname: Koshino
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: H
authors.initials: H
authors.lastname: Takasaki
mesh_terms: D000328:Adult; D001285:Atropine / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D006801:Humans; D008297:Male; D008409:Mastication / Q000502:physiology*; D018721:Muscarinic Agonists / Q000494:pharmacology; D010862:Pilocarpine / Q000494:pharmacology; D012463:Saliva / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D018680:Cholinergic Antagonists; D018721:Muscarinic Agonists; D010862:Pilocarpine; D001285:Atropine