title: Hypertensive disorders in Japanese women with gestational glucose intolerance.
abstract: We investigated the relationship between gestational glucose intolerance and the development of pregnancy-induced hypertension including gestational hypertension (GH) and preeclampsia. Consecutive Japanese women with singleton pregnancies underwent a standard 1h, 50g oral glucose challenge test (GCT) at 24-27 weeks of gestation, followed by a 75g, 2h oral glucose tolerance test (OGTT) if the GCT result exceeded 130mg/dl. Using criteria of the Japan Society of Obstetrics and Gynecology, gestational diabetes mellitus (GDM) was defined by two or more abnormal OGTT values and mild glucose intolerance by one abnormal value. The normal glucose tolerance group included women with GCT results below 130mg/dl or normal OGTT values. GH was defined as blood pressure of at least 140/90mmHg occurring for the first time after mid-pregnancy, without proteinuria. Preeclampsia was determined as GH with proteinuria. Of 2651 consecutive patients, 49 women were found to have GDM, and 139 showed mild glucose intolerance. Sixty patients showed GH, and 58 developed preeclampsia. The frequency of GH in mild glucose intolerance or GDM was 5.8% or 8.2%, respectively, significantly greater than in normal glucose tolerance (P<0.01). Incidence of preeclampsia was not significantly increased in women with mild glucose intolerance or GDM (2.2% or 4.1%, respectively, compared to those with normal glucose tolerance). Japanese women with gestational glucose intolerance therefore have an increased risk of developing GH.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. kei@sc.itc.keio.ac.jp
authors.forename: Kei
authors.initials: K
authors.lastname: Miyakoshi
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hattori
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ueno
authors.forename: Takahide
authors.initials: T
authors.lastname: Teranishi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Minegishi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology; D001786:Blood Glucose / Q000032:analysis / Q000502:physiology; D016640:Diabetes, Gestational / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D018149:Glucose Intolerance / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D007564:Japan / Q000453:epidemiology; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000453:epidemiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose