Childhood acute myelomonocytic leukemia (AML-M4) presenting as catastrophic antiphospholipid antibody syndrome.
: The authors describe a 15-year-old girl presenting with a cerebral ischemic stroke as the first manifestation of catastrophic antiphospholipid antibody syndrome secondary to acute myeloid leukemia (AML). Despite treatment with anticoagulants, therapeutic plasma exchange, and chemotherapy, the patient developed multiorgan thromboses and failure, eventually culminating in death. This unusual presentation of AML has not been previously described in children. Clinical features of antiphospholipid antibody syndrome and current knowledge regarding its association with malignancies are reviewed.
Orsino
Angela
A
Division of Rheumatology, Hospital for Sick Children, Toronto, Ontario, Canada.
Schneider
Rayfel
R
DeVeber
Gabrielle
G
Grant
Ronald
R
Massicotte
Patricia
P
Canning
Patricia
P
Carcao
Manuel
M
D000293:Adolescent; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000209:etiology*; D002388:Catastrophic Illness; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000175:diagnosis*; D020521:Stroke / Q000209:etiology; D013927:Thrombosis / Q000209:etiology; D017211:Treatment Failure
D017152:Antibodies, Antiphospholipid