title: Synergetic inhibition of genistein and D-glucose on alpha-glucosidase.
abstract: Synergetic inhibitory effect of genistein (I2) and D-glucose (I1) on alpha-glucosidase has been studied with kinetics method. It was concluded that the inhibitory effect was much greater when I2 and I1 were both added to the reactant solution simultaneously than that they were added, respectively, which suggesting the inhibitors bind to the different sites of alpha-glucosidase at the same time, and demonstrating synergetic inhibition.
authors.affiliation: School of Chemistry and Chemical Engineering, SUN Yat-sen (Zhongshan) University, 510275 Guangzhou, China.
authors.forename: Yufang
authors.initials: Y
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.forename: Chaole
authors.initials: C
authors.lastname: Pang
authors.forename: Minju
authors.initials: M
authors.lastname: Huang
authors.forename: Zhishu
authors.initials: Z
authors.lastname: Huang
authors.forename: Lianquan
authors.initials: L
authors.lastname: Gu
mesh_terms: D004357:Drug Synergism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005656:Fungal Proteins; D019833:Genistein / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D007700:Kinetics
chemical_list: D004791:Enzyme Inhibitors; D005656:Fungal Proteins; D065089:Glycoside Hydrolase Inhibitors; D019833:Genistein; D005947:Glucose