title: Interposition vein cuff and intimal hyperplasia: an experimental study.
abstract: OBJECTIVE
  There is some evidence to suggest that prosthetic distal bypass graft patency can be improved, and the risk of intimal hyperplasia diminished, by interposing a distal vein cuff. We studied intimal remodeling in an end-to-side distal prosthetic anastomosis constructed with and without a vein cuff.
  
  
  METHODS
  Twenty-four prosthetic bypasses were constructed with (N=12) or without (N=12) a distal vein cuff in 12 pigs. At 10 weeks, the 20 anastomoses and adjacent arteries from the surviving 10 pigs were studied by histology, immunohistochemistry and morphometry.
  
  
  RESULTS
  Intimal hyperplasia was significantly less on all zones of the arterial floor and all suture zone of arteries anastomosed with a vein cuff than within arteries anastomosed without a vein cuff (0.11 versus 0.34; p=0.001 and 0.35 versus 1.19; p=0.0001, respectively). Intimal hyperplasia was also more prominent within the vein cuff than within the recipient artery, with or without a vein cuff (1.35 versus 0.38; p=0.0001).
  
  
  CONCLUSIONS
  An interposition vein cuff at the distal anastomosis between a prosthesis and an artery alters the distribution of intimal hyperplasia. By acting as an expansion chamber where intimal hyperplasia can develop harmlessly, the vein cuff may protect the arterial anastomosis from stenosis.
authors.affiliation: Unit of Cytology and Pathological Anatomy, Catholic Institute of Lille, Lille, France.
authors.forename: E
authors.initials: E
authors.lastname: Ducasse
authors.forename: L
authors.initials: L
authors.lastname: Fleurisse
authors.forename: G
authors.initials: G
authors.lastname: Vernier
authors.forename: F
authors.initials: F
authors.lastname: Speziale
authors.forename: P
authors.initials: P
authors.lastname: Fiorani
authors.forename: P
authors.initials: P
authors.lastname: Puppinck
authors.forename: C
authors.initials: C
authors.lastname: Creusy
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001807:Blood Vessel Prosthesis; D005260:Female; D006965:Hyperplasia; D011138:Polytetrafluoroethylene; D013552:Swine; D017539:Tunica Intima / Q000473:pathology*; D014654:Vascular Patency; D014680:Veins / Q000601:surgery
chemical_list: D011138:Polytetrafluoroethylene