Successful treatment of Staphylococcus epidermidis hip prosthesis infection with oral linezolid.
OBJECTIVE
To report a case of Staphylococcus epidermidis infection of a hip prosthesis successfully treated with oral linezolid.


METHODS
A 46-year-old woman developed methicillin-resistant S. epidermidis (MRSE) infection of her prosthetic hip. She received oral linezolid 600 mg twice daily for one month; after that time, the biological inflammatory markers returned to normal.


CONCLUSIONS
One of the most serious complications of arthroplasty is joint prosthesis infection. It is mainly caused by gram-positive bacteria, in particular those of the genus staphylococcus. The increasing prevalence of gram-positive cocci that are resistant to antimicrobial agents has complicated the treatment of serious infections.


CONCLUSIONS
Oral linezolid appears to be an effective and well-tolerated treatment option for hip prosthesis infections due to MRSE.
Mogenet
Ingrid
I
Pharmacy Department, Rangueil University Hospital, Toulouse, France. imogenet@chu-clermontferrand@fr
Raetz-Dillon
Sabine
S
Canonge
Jean-Marie
JM
Archambaud
Maryse
M
Bonnet
Eric
E
D000081:Acetamides / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006622:Hip Prosthesis / Q000382:microbiology*; D006801:Humans; D000069349:Linezolid; D016106:Methicillin Resistance; D008875:Middle Aged; D023303:Oxazolidinones / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid