title: Changes in brain anatomy in focal hand dystonia.
abstract: No consistent cerebral anatomical abnormality has ever been reported in primary focal hand dystonia (FHD). The present voxel-based morphometry study showed a significant bilateral increase in gray matter in the hand representation area of primary somatosensory and, to a lesser extent, primary motor cortices in 36 patients with unilateral FHD compared with 36 controls. The presence of anatomical changes in the perirolandic cortex for the unaffected hand as well as that for the affected hand suggests that these disturbances may be, at least in part, primary.
authors.affiliation: Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
authors.forename: Gaëtan
authors.initials: G
authors.lastname: Garraux
authors.forename: Andrew
authors.initials: A
authors.lastname: Bauer
authors.forename: Takashi
authors.initials: T
authors.lastname: Hanakawa
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Kenji
authors.initials: K
authors.lastname: Kansaku
authors.forename: Mark
authors.initials: M
authors.lastname: Hallett
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D020821:Dystonic Disorders / Q000473:pathology*; D005260:Female; D006225:Hand / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged