title: Antioxidative phenylethanoid and phenolic glycosides from Picrorhiza scrophulariiflora.
abstract: One new phenylenthanoid glycoside, scroside D (2), was isolated from the roots of Picrorhiza scrophulariiflora (Scrophulariaceae), together with nine known phenylethanoid and phenolic glycosides: 2-(3,4-dihydroxyphenyl)-ethyl-O-beta-D-glucopyranoside (1), 2-(3-hydroxy-4-methoxyphenyl)-ethyl-O-beta-D-glucopyranosyl (1-->3)-beta-D-glucopyranoside (3), scroside B (4), hemiphroside A (5), plantainoside D (6), scroside A (7), androsin (8), piceoside (9), and 6-O-feruloyl-beta-D-glucopyranoside (10). The structures of these compounds were elucidated using spectroscopic methods. The antioxidative activities of these isolated compounds were evaluated based on their scavenging effects on hydroxyl radicals and superoxide anion radicals, respectively. Compounds 1, 2, and 6 showed potent antioxidative effects as those of ascorbic acid and the structure-activity relationship is discussed.
authors.affiliation: Department of Phytochemistry, China Pharmaceutical University, Nanjing, P.R.China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Fei
authors.initials: F
authors.lastname: Xiong
authors.forename: Jia-Jun
authors.initials: JJ
authors.lastname: Wu
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Yang
authors.forename: Shou-Xun
authors.initials: SX
authors.lastname: Zhao
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives / Q000302:isolation & purification; D032261:Picrorhiza; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots
chemical_list: D000975:Antioxidants; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D010626:Phenylethyl Alcohol