title: Synthesis and biological activity of macrocyclic taxane analogues.
abstract: A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.
authors.affiliation: Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5100, Wallingford, CT 06492-7660, USA. jim_tarrant@nrgn.com
authors.forename: James G
authors.initials: JG
authors.lastname: Tarrant
authors.forename: Donald
authors.initials: D
authors.lastname: Cook
authors.forename: Craig
authors.initials: C
authors.lastname: Fairchild
authors.forename: John F
authors.initials: JF
authors.lastname: Kadow
authors.forename: Byron H
authors.initials: BH
authors.lastname: Long
authors.forename: William C
authors.initials: WC
authors.lastname: Rose
authors.forename: Dolatrai
authors.initials: D
authors.lastname: Vyas
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D019008:Drug Resistance, Neoplasm; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D017239:Paclitaxel / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D050257:Tubulin Modulators
chemical_list: D000970:Antineoplastic Agents; D047028:Macrocyclic Compounds; D043823:Taxoids; D050257:Tubulin Modulators; D017239:Paclitaxel