title: Detection of polyomavirus DNA in human brain tumors.
abstract: OBJECTIVE
  To investigate surgically resected human brain tumors for the presence of polyomavirus DNA.
  
  
  METHODS
  65 samples of surgically resected human brain tumors (57 tumors were of neuroectodermal genesis, 4--mesenchimal, 4--metastatic tumors) were examined for the presence of viral DNA by PCR analysis.
  
  
  RESULTS
  DNA of polyomaviruses was found in oligodendroligomas (66.7% of cases), oligodendroastrocytomas (66.7% of cases) and glioblastomas (40% of cases). In metastatic tumors viral infection had not been detected. No correlation between the grade of brain tumors and infection with polyomavirus DNA has been revealed.
  
  
  CONCLUSIONS
  Our data point to importance of investigation of the brain tumors and cerebrospinal fluid for determination of viral infection.
authors.affiliation: A.P. Romodanov Institute of Neurosurgery of Academy of Medical Sciences of Ukraine, Kyiv, Ukraine. ira@neuro.kiev.ua
authors.forename: Iryna G
authors.initials: IG
authors.lastname: Vasilyeva
authors.forename: Mikhail I
authors.initials: MI
authors.lastname: Shamaev
authors.forename: Alexandr Ya
authors.initials: AY
authors.lastname: Glavatskiy
authors.forename: Natalya G
authors.initials: NG
authors.lastname: Chopick
authors.forename: Natalya P
authors.initials: NP
authors.lastname: Olexenko
authors.forename: Olga I
authors.initials: OI
authors.lastname: Tsyubko
authors.forename: Elena S
authors.initials: ES
authors.lastname: Galanta
authors.forename: Tatyana A
authors.initials: TA
authors.lastname: Malisheva
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000821:virology*; D002555:Cerebrospinal Fluid / Q000821:virology; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011120:Polyomavirus / Q000235:genetics / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000473:pathology / Q000821:virology*; D014412:Tumor Virus Infections / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral