title: Oxidative stress and non-enzymatic antioxidative status in dogs with visceral Leishmaniasis.
abstract: Leishmaniasis is a potentially fatal chronic protozoan disease in human, canine and rodent species. The infection by Leishmania is endemic in the Mediterranean Sea region, Africa, Asia and South America. Canine visceral leishmaniasis (CanVL) is a systemic disease caused by Leishmania infantum and Leishmania chagasi from the Leishmania donovani complex group. The blood glutathione (GSH), plasma malondialdehyde (MDA), ascorbic acid (AA), beta-carotene, retinol and ceruloplasmin levels of dogs with CanVL were investigated to establish the status of the antioxidant defense mechanism in the infected animals. Dogs diagnosed as CanVL with amastigotes in lymph node smear examination and/or antibody titers > or = 128 were used as subjects, while those with no serological response against leishmaniasis were used as healthy controls. The glutathione and retinol amounts were decreased although not significantly (p > 0.05), but the MDA levels were significantly higher in dogs with VL, suggesting increased lipid peroxidation.
authors.affiliation: Department of Biochemistry, Faculty of Veterinary Medicine, Adnan Menderes University, 09016 Aydin, Turkey. bildik65@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Bildik
authors.forename: F
authors.initials: F
authors.lastname: Kargin
authors.forename: K
authors.initials: K
authors.lastname: Seyrek
authors.forename: S
authors.initials: S
authors.lastname: Pasa
authors.forename: S
authors.initials: S
authors.lastname: Ozensoy
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D004283:Dog Diseases / Q000097:blood* / Q000469:parasitology; D004285:Dogs; D005260:Female; D019085:Fluorescent Antibody Technique, Direct / Q000662:veterinary; D005978:Glutathione / Q000097:blood; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000469:parasitology / Q000662:veterinary*; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008853:Microscopy / Q000662:veterinary; D018384:Oxidative Stress; D014801:Vitamin A / Q000097:blood; D019207:beta Carotene / Q000097:blood
chemical_list: D000975:Antioxidants; D019207:beta Carotene; D014801:Vitamin A; D008315:Malondialdehyde; D002570:Ceruloplasmin; D005978:Glutathione; D001205:Ascorbic Acid