title: Analysis of factors influencing pregnancy rates in homologous intrauterine insemination.
abstract: OBJECTIVE
  To identify predictors of pregnancy rate (PR) among women undergoing homologous IUI.
  
  
  METHODS
  Cross-sectional analysis of IUI cycles carried out from January 2000 to September 2002.
  
  
  METHODS
  Private infertility center in Alicante, Spain.
  
  
  METHODS
  Four hundred seventy women undergoing 1,010 cycles of IUI.
  
  
  METHODS
  Single IUI with ovarian stimulation using hMG.
  
  
  METHODS
  Preovulatory follicles (>15 mm), motile spermatozoa count, type and duration of infertility, female age, insemination timing, and cycle number.
  
  
  RESULTS
  Overall PR per cycle and multiple pregnancy and miscarriage rates were 9.2%, 8.6%, and 11.8%, respectively. Three significant predictors of pregnancy were identified by multiple logistic regression analysis: preovulatory follicles, spermatozoa count, and infertility duration. Interuterine insemination with three follicles almost tripled the PR with respect to only one, odds ratio (OR) = 2.89 (95% confidence interval [CI], 1.54-5.41). Compared with insemination with a motile sperm count >30 x, 20.1-30, 10.1-20, 5.1-10, and < or =5 x10(6), insemination progressively decreased the PR, from 15.3% in the highest category to 3.6% in the lowest (OR lowest/highest = 0.20 [95% CI: 0.09-0.45]), with a statistically significant dose-response trend. Infertility duration > or =3 years was marginally associated with a lower PR, OR = 0.65 (95% CI, 0.40-1.04). Overall, female age was not a significant predictor of pregnancy, and although PR slightly decreased beyond two IUI cycles and when a single IUI was performed 36-40 hours after hCG administration, results were not statistically significant.
  
  
  CONCLUSIONS
  Homologous IUI achieves the best results with two or three induced follicles, a high motile spermatozoa count, and infertility duration <3 years, irrespective of female age and fertility history.
authors.affiliation: Infertility Center, Instituto Bernabeu, Alicante, Spain.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Ibérico
authors.forename: Jesús
authors.initials: J
authors.lastname: Vioque
authors.forename: Nuria
authors.initials: N
authors.lastname: Ariza
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Lozano
authors.forename: Manuela
authors.initials: M
authors.lastname: Roca
authors.forename: Joaquín
authors.initials: J
authors.lastname: Llácer
authors.forename: Rafael
authors.initials: R
authors.lastname: Bernabeu
mesh_terms: D000293:Adolescent; D000328:Adult; D003362:Cost-Benefit Analysis; D003376:Counseling; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007317:Insemination, Artificial, Homologous; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D018873:Pregnancy Rate; D013997:Time Factors