title: [Therapeutic angiogenesis by autologous transplantation of bone-marrow cells in a patient with progressive limb ischemia due to arteriosclerosis obliterans: a case report].
abstract: A 78-year-old woman with arteriosclerosis obliterans was admitted with complaints of progressive ischemic change and resting pain of the left leg. She had severe ischemic limb in stage IV of the Fontaine classification. Angiography showed total occlusion of the three main arteries with poor collateral flow at the left crus. Autologous transplantation of bone-marrow mononuclear cell to her left leg was performed to achieve therapeutic angiogenesis. One month later, follow-up angiography showed excellent angiogenesis of collateral vessels at the left crus. Her pain was relieved and leg amputation was not necessary. Recently, the TACT study in Japan showed the efficacy of angiogenesis by autologous bone-marrow transplantation for peripheral artery disease. This case illustrates the efficacy of this therapy.
authors.affiliation: Second Department of Internal Medicine, Yamanashi University School of Medicine, Shimokatoh 1110, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hasebe
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Osada
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kodama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Fujioka
authors.forename: Keita
authors.initials: K
authors.lastname: Sano
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tohru
authors.initials: T
authors.lastname: Mitsumori
authors.forename: Kazuto
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kitta
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Ichiki
authors.forename: Jyunei
authors.initials: J
authors.lastname: Obata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kawabata
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Yanagi
authors.forename: Sohichi
authors.initials: S
authors.lastname: Sano
authors.forename: Hajime
authors.initials: H
authors.lastname: Takano
authors.forename: Ken
authors.initials: K
authors.lastname: Umetani
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kugiyama
mesh_terms: D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000150:complications* / Q000628:therapy*; D016026:Bone Marrow Transplantation; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000209:etiology* / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D014182:Transplantation, Autologous; D016896:Treatment Outcome