title: Light at night and cancer risk.
abstract: Environmental lighting powerfully suppresses the physiologic release of melatonin, which typically peaks in the middle of the night. This decreased melatonin production has been hypothesized to increase the risk of cancer. Evidence from experimental studies supports a link between melatonin and tumor growth. There is also fairly consistent indirect evidence from observational studies for an association between melatonin suppression, using night work as a surrogate, and breast cancer risk.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. eva.schernhammer@channing.harvard.edu
authors.forename: Eva
authors.initials: E
authors.lastname: Schernhammer
authors.forename: Karl
authors.initials: K
authors.lastname: Schulmeister
mesh_terms: D000818:Animals; D002455:Cell Division; D003624:Darkness; D006801:Humans; D008027:Light / Q000009:adverse effects*; D008029:Lighting / Q000009:adverse effects; D008550:Melatonin / Q000096:biosynthesis / Q000172:deficiency*; D009369:Neoplasms / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D016273:Occupational Exposure / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014940:Work Schedule Tolerance / Q000502:physiology
chemical_list: D008550:Melatonin