title: Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain.
abstract: The research in the field of AP-1 transcription factor expression, such as Jun or Fos proteins, in the brain was a milestone in neurosciences. The last years have provided growing insights into the upstream signal transduction which controls the expression and activation of these transcriptional regulators. In particular, the c-Jun N-terminal kinases (JNKs) were considered to confer degeneration by activation of c-Jun. Recent findings, however, demonstrate an essential physiological role of JNKs in the nervous system. Here we review the specific control and dual functions of JNK isoforms which are relevant for the development of the intact brain on the one hand, and which can confer dramatic neurodegenerative effects and microglial activation on the other hand.
authors.affiliation: Institute of Pharmacology, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany.
authors.forename: Vicki
authors.initials: V
authors.lastname: Waetzig
authors.forename: Thomas
authors.initials: T
authors.lastname: Herdegen
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000503:physiopathology; D016923:Cell Death / Q000235:genetics; D004660:Encephalitis / Q000201:enzymology / Q000503:physiopathology; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D008322:Mammals; D017628:Microglia / Q000201:enzymology; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000201:enzymology* / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics
chemical_list: D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases