title: Rat liver lipogenesis is modulated by interleukin-15.
abstract: Interleukin-15 (IL-15) administration to rats resulted in an important decrease in carcass fat (27%) and, consequently, in white adipose tissue mass. This decrease was linked with a decreased lipogenic rate (per g of tissue) in both adipose tissue (53%) and liver (36%). The decrease in hepatic lipogenesis was associated with lower hepatic citrate levels (49%) and a reduced activity of lipogenic enzymes. The results presented here further demonstrate the involvement of IL-15 in lipid metabolism. Thus, IL-15 seems to be able to modulate de novo fatty acid synthesis, possibly by influencing citrate tissue levels, an allosteric activator of the key lipogenic enzyme acetyl-CoA carboxylase.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
authors.forename: Joaquín
authors.initials: J
authors.lastname: López-Soriano
authors.forename: Neus
authors.initials: N
authors.lastname: Carbó
authors.forename: Vanessa
authors.initials: V
authors.lastname: Almendro
authors.forename: Maite
authors.initials: M
authors.lastname: Figueras
authors.forename: Vicent
authors.initials: V
authors.lastname: Ribas
authors.forename: Sílvia
authors.initials: S
authors.lastname: Busquets
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: López-Soriano
authors.forename: Josep M
authors.initials: JM
authors.lastname: Argilés
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis*; D019409:Interleukin-15 / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D019409:Interleukin-15; D000103:Acetyl-CoA Carboxylase