title: Improving binding potential analysis in [11C]raclopride PET studies using cluster analysis.
abstract: To calculate binding potentials (BP) in [11C]raclopride brain PET studies a reference tissue model is widely used. The aim of the present study was to improve the determination of time activity curves (TAC) of reference tissue regions using cluster analysis. In four patients with Huntington disease TACs of a cerebellar reference region were calculated either from manually placed circular ROIs within the cerebellum or by cluster analysis. BP estimates derived from cluster analysis are independent from inter- and intraobserver variations and show an improved reproducibility combined with a low variability compared to manually placed cerebellar ROIs. This is of high value in longitudinal studies.
authors.affiliation: Department of Nuclear Medicine, University of Ulm, 89070 Ulm, Germany. gerhard.glatting@medizin.uni-ulm.de
authors.forename: Gerhard
authors.initials: G
authors.lastname: Glatting
authors.forename: Felix M
authors.initials: FM
authors.lastname: Mottaghy
authors.forename: Jochen
authors.initials: J
authors.lastname: Karitzky
authors.forename: Axel
authors.initials: A
authors.lastname: Baune
authors.forename: Friedrich T
authors.initials: FT
authors.lastname: Sommer
authors.forename: G Bernhard
authors.initials: GB
authors.lastname: Landwehrmeyer
authors.forename: Sven N
authors.initials: SN
authors.lastname: Reske
mesh_terms: D000328:Adult; D000465:Algorithms; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000378:metabolism*; D016000:Cluster Analysis; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging* / Q000378:metabolism*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011485:Protein Binding; D020891:Raclopride / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; D020891:Raclopride