[Validation of lipids on body mass index reference recommended by Obesity Working Group, International Life Science Association of China].
OBJECTIVE
To assess the relationship between overweight, obesity and blood lipid profiles of children and adolescents and to validate body mass index (BMI) cutoff points for overweight and obesity screening to Chinese children and adolescents, recommended by Working Group of Obesity, China (WGOC), International Life Science Association.


METHODS
2293 children and adolescents (1124 males and 1169 females), aged between 10 and 18 years, were randomly selected as samples from 6 schools in Beijing area. Fasting serum lipids including total cholesterol (TC), total triglycerides (TG), high density lipoprotein cholesterol (HDLC), thropometrical index as weight and height were measured. BMI equals to weight in kilograms were then divided by the square of height in meters.


RESULTS
According to BMI cutoff points recommended by WGOC, samples fell into 3 groups including normal group (BMI < 85 percentiles), overweight group (BMI >or= 85 and < 95 percentiles) and obesity group (BMI >or= 95 percentiles). Results clearly showed an increase of both serum TC and TG and a decrease of HDLC when BMI was increasing, among most age groups regardless of sex difference and the difference among BMI groups was statistically significant (P < 0.05 or P < 0.01).


CONCLUSIONS
Results of this study indicated that there was an obvious dose-effect relationship between BMI and lipid profiles which accounted for some rationality of the BMI cutoff points recommended by WGOC. The authors reckoned the findings important to managing relevant adult diseases during childhood, in China.
Zhai
Feng-ying
FY
Institute of Nutrition and Food Safety, Chinese Center of Disease Control and Prevention, Beijing 100050, China.
Zhang
Li-wei
LW
Wang
Chun-rong
CR
Duan
Jia-li
JL
Cao
Ruo-xiang
RX
Wang
Hui-jun
HJ
Zhang
Jian
J
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D017408:Guidelines as Topic / Q000592:standards; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000175:diagnosis*; D015203:Reproducibility of Results; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol