Finding Cinderella after the ball: a three-hybrid approach to drug target identification.
A major bottleneck in drug discovery is identifying the targets of small molecules. The yeast three-hybrid assay extends the two-hybrid approach to screen for protein-small molecule interactions. In this issue of Chemistry & Biology, GPC Biotech reports the first application of this promising assay.
Lefurgy
Scott
S
Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Cornish
Virginia
V
D016503:Drug Delivery Systems / Q000379:methods*; D015723:Gene Library; D020798:Two-Hybrid System Techniques