title: Star-cross'd neurons: astroglial effects on neural repair in the adult mammalian CNS.
abstract: Astroglia have long been thought to play merely a supporting role in the life of the neuron. However, these star-shaped cells have recently been the focus of intense study that has begun to emphasize remarkable and novel roles for these amazing cells. While astroglia play positive roles in the life of the neuron, they can simultaneously exert negative influences. Kinouchi et al. convincingly demonstrate and characterize an inhibitory role played by astroglia after neuronal transplantation. These findings remind us that astroglia exert positive and negative influences on neuronal survival, migration, neurite outgrowth and functional integration. Here, we review the complementary and often contradictory roles of astroglia during neuronal integration.
authors.affiliation: MGH-HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, and Program in Neuroscience, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.
authors.forename: Jason G
authors.initials: JG
authors.lastname: Emsley
authors.forename: Paola
authors.initials: P
authors.lastname: Arlotta
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Macklis
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D002478:Cells, Cultured; D002490:Central Nervous System / Q000166:cytology*; D005904:Glial Fibrillary Acidic Protein / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009474:Neurons / Q000145:classification / Q000502:physiology*; D014746:Vimentin / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin