Videokeratographic anomalies in familial keratoconus.
OBJECTIVE
To analyze videokeratography of relatives of established familial keratoconus (FK) patients to detect low-expressivity keratoconus and improve the diagnosis criteria of forme fruste keratoconus.


METHODS
Multicenter case-control study.


METHODS
Twenty-three families with 55 clinical keratoconus patients, 89 first-degree relatives, 43 other relatives, and a control group of 130 subjects.


METHODS
Videokeratography was performed on both eyes of patients after clinical examination, and corneal maps were analyzed. Statistical comparisons were conducted between first-degree and other relatives and a control population.


METHODS
Qualitative (using a 0.5-diopter [D] increment scale) and quantitative analyses of videokeratographs.


RESULTS
Two corneal patterns were overrepresented in the relatives of FK patients: the J and inverted-J form patterns. Results of the quantitative analysis of these suspect patterns showed that the inferior - superior values (reflecting the inferior - superior dioptric asymmetry) were close to 0.8 D and the Srax (relative skewing of the steepest radial axes) was superior to 21 degrees.


CONCLUSIONS
Our study using topography in clearly established genetic keratoconus families allowed us to detect suspect topographical patterns and brings new data to the difficult task of diagnosing forme fruste keratoconus.
Levy
David
D
Service Ophtalmologie, Hôpital Purpan, Toulouse, France.
Hutchings
Helen
H
Rouland
Jean F
JF
Guell
José
J
Burillon
Carole
C
Arné
Jean L
JL
Colin
Joseph
J
Laroche
Laurent
L
Montard
Michel
M
Delbosc
Bernard
B
Aptel
Isabelle
I
Ginisty
Hervé
H
Grandjean
Hélène
H
Malecaze
Francois
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003315:Cornea / Q000473:pathology*; D019781:Corneal Topography; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies