title: Follicular lymphoma international prognostic index.
abstract: The prognosis of follicular lymphomas (FL) is heterogeneous and numerous treatments may be proposed. A validated prognostic index (PI) would help in evaluating and choosing these treatments. Characteristics at diagnosis were collected from 4167 patients with FL diagnosed between 1985 and 1992. Univariate and multivariate analyses were used to propose a PI. This index was then tested on 919 patients. Five adverse prognostic factors were selected: age (> 60 years vs < or = 60 years), Ann Arbor stage (III-IV vs I-II), hemoglobin level (< 120 g/L vs > or = 120 g/L), number of nodal areas (> 4 vs < or = 4), and serum LDH level (above normal vs normal or below). Three risk groups were defined: low risk (0-1 adverse factor, 36% of patients), intermediate risk (2 factors, 37% of patients, hazard ratio [HR] of 2.3), and poor risk (> or = 3 adverse factors, 27% of patients, HR = 4.3). This Follicular Lymphoma International Prognostic Index (FLIPI) appeared more discriminant than the International Prognostic Index proposed for aggressive non-Hodgkin lymphomas. Results were very similar in the confirmation group. The FLIPI may be used for improving treatment choices, comparing clinical trials, and designing studies to evaluate new treatments.
authors.affiliation: Centre Jean-Bernard, 9 rue Beauverger, 72000 Le Mans, France. p.solal-celigny@noos.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Solal-Céligny
authors.forename: Pascal
authors.initials: P
authors.lastname: Roy
authors.forename: Philippe
authors.initials: P
authors.lastname: Colombat
authors.forename: Josephine
authors.initials: J
authors.lastname: White
authors.forename: Jim O
authors.initials: JO
authors.lastname: Armitage
authors.forename: Reyes
authors.initials: R
authors.lastname: Arranz-Saez
authors.forename: Wing Y
authors.initials: WY
authors.lastname: Au
authors.forename: Monica
authors.initials: M
authors.lastname: Bellei
authors.forename: Pauline
authors.initials: P
authors.lastname: Brice
authors.forename: Dolores
authors.initials: D
authors.lastname: Caballero
authors.forename: Bertrand
authors.initials: B
authors.lastname: Coiffier
authors.forename: Eulogio
authors.initials: E
authors.lastname: Conde-Garcia
authors.forename: Chantal
authors.initials: C
authors.lastname: Doyen
authors.forename: Massimo
authors.initials: M
authors.lastname: Federico
authors.forename: Richard I
authors.initials: RI
authors.lastname: Fisher
authors.forename: Javier F
authors.initials: JF
authors.lastname: Garcia-Conde
authors.forename: Cesare
authors.initials: C
authors.lastname: Guglielmi
authors.forename: Anton
authors.initials: A
authors.lastname: Hagenbeek
authors.forename: Corinne
authors.initials: C
authors.lastname: Haïoun
authors.forename: Michael
authors.initials: M
authors.lastname: LeBlanc
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Lister
authors.forename: Armando
authors.initials: A
authors.lastname: Lopez-Guillermo
authors.forename: Peter
authors.initials: P
authors.lastname: McLaughlin
authors.forename: Noël
authors.initials: N
authors.lastname: Milpied
authors.forename: Pierre
authors.initials: P
authors.lastname: Morel
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mounier
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Proctor
authors.forename: Ama
authors.initials: A
authors.lastname: Rohatiner
authors.forename: Paul
authors.initials: P
authors.lastname: Smith
authors.forename: Pierre
authors.initials: P
authors.lastname: Soubeyran
authors.forename: Hervé
authors.initials: H
authors.lastname: Tilly
authors.forename: Umberto
authors.initials: U
authors.lastname: Vitolo
authors.forename: Pier-Luigi
authors.initials: PL
authors.lastname: Zinzani
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.forename: Emili
authors.initials: E
authors.lastname: Montserrat
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis