Inactivation of the murine Transferrin Receptor 2 gene using the Cre recombinase: loxP system.
Transferrin Receptor 2 (TfR2) is a key molecule involved in the regulation of iron homeostasis. Mutations in TfR2 lead to type 3 hemochromatosis in humans. We have developed mice with a targeted deletion of TfR2. The Cre-recombinase:loxP system used to create the mice allows both full deletion and tissue-specific deletion of TfR2. The development of these mice will provide new models for type 3 hemochromatosis and assist in determining the role of TfR2 in iron metabolism.
Wallace
Daniel F
DF
Membrane Transport Laboratory, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia.
Tonks
Ian D
ID
Zournazi
Anna
A
Kay
Graham F
GF
Subramaniam
V Nathan
VN
D000818:Animals; D015153:Blotting, Western; D020868:Gene Silencing; D005822:Genetic Vectors; D006432:Hemochromatosis / Q000235:genetics / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D011990:Receptors, Transferrin / Q000235:genetics / Q000502:physiology*; D045522:Recombinases / Q000235:genetics*
D011990:Receptors, Transferrin; D045522:Recombinases; C503641:TFR2 protein, mouse; D007501:Iron