Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection.
OBJECTIVE
To evaluate the incidence of aneuploidy in miscarriages after IVF and intracytoplasmic sperm injection (ICSI) procedures.


METHODS
Retrospective study.


METHODS
University IVF program.


METHODS
All IVF patients with missed abortions undergoing uterine curettage.


METHODS
Cytogenetic analysis of products of conception (POC).


METHODS
Incidence of aneuploidy in POC.


RESULTS
Thirty-two of 59 specimens (54%) reviewed were abnormal. The patients with ICSI were more likely to have aneuploidy identified in their POC than conventional IVF, 76% vs. 41%. The average ages in these groups were similar: 37.1 vs. 37.8 years. There was a trend toward decreased aneuploidy with day 5 compared to day 3 embryo transfers; 38% vs. 63%.


CONCLUSIONS
We found a significantly higher aneuploidy rate in the abortuses of patients who conceived with ICSI. It is possible that this increased incidence is due to abnormalities in the sperm of patients with ICSI, but could also be partially related to the technique itself.
Lathi
Ruth B
RB
Stanford University Medical Center, Department of Obstetrics/Gynecology, Division of Reproductive Endocrinology and Infertility, Stanford University Medical Center, Stanford, California 94305, USA.
Milki
Amin A
AA
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D000782:Aneuploidy; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D008297:Male; D012729:Sex Chromosome Aberrations; D020554:Sperm Injections, Intracytoplasmic