The receptor activity modifying protein family of G protein coupled receptor accessory proteins.
Receptor diversity for the calcitonin peptide family is created by the interaction of two 7-transmembrane proteins--the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CL-R)--with the receptor activity modifying protein (RAMP) family. The discovery of heterodimeric complexes of these proteins heralded a new era in the study of G protein coupled receptors (GPCRs), whereby receptor phenotype is no longer governed by just the GPCR. In this article, recent advances in the study of RAMPs are discussed--from our current understanding of the molecular basis of RAMP-receptor interaction to a broader role for RAMPs outside the calcitonin receptor family.
Udawela
Madhara
M
Molecular Pharmacology Group, Howard Florey Institute, The University of Melbourne, Gate 11, Royal Parade, Melbourne, Vic. 3010, Australia.
Hay
Debbie L
DL
Sexton
Patrick M
PM
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D011485:Protein Binding; D058261:Receptor Activity-Modifying Proteins; D018003:Receptors, Calcitonin / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D058261:Receptor Activity-Modifying Proteins; D018003:Receptors, Calcitonin; D043562:Receptors, G-Protein-Coupled