Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
Gregory
Matthew A
MA
Department of Biochemistry and Cambridge Centre for Molecular Recognition, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
Gaisser
Sabine
S
Lill
Rachel E
RE
Hong
Hui
H
Sheridan
Rose M
RM
Wilkinson
Barrie
B
Petkovic
Hrvoje
H
Weston
Alison J
AJ
Carletti
Isabelle
I
Lee
Huai-Lo
HL
Staunton
James
J
Leadlay
Peter F
PF
D003001:Cloning, Molecular; D008401:Gas Chromatography-Mass Spectrometry; D005798:Genes, Bacterial / Q000235:genetics; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020123:Sirolimus / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D007166:Immunosuppressive Agents; C488301:pre-rapamycin; D020123:Sirolimus