Use of an ionic liquid in a two-phase system to improve an alcohol dehydrogenase catalysed reduction.
Due to favourable partition coefficients the highly enantioselective reduction of 2-octanone, catalysed by an alcohol dehydrogenase from Lactobacillus brevis, is faster in a biphasic system containing buffer and the ionic liquid [BMIM][(CF(3)SO(2))(2)N] compared to the reduction in a biphasic system containing buffer and methyl tert-butyl ether.
Eckstein
Marrit
M
Rostock University, Department of Chemistry, 18051 Rostock, Germany.
Villela Filho
Murillo
M
Liese
Andreas
A
Kragl
Udo
U
D019840:2-Propanol / Q000737:chemistry; D000096:Acetone / Q000737:chemistry; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D002021:Buffers; D002384:Catalysis; D007477:Ions / Q000737:chemistry; D007659:Ketones / Q000737:chemistry / Q000378:metabolism; D007778:Lactobacillus / Q000201:enzymology; D008738:Methyl Ethers / Q000737:chemistry; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D044367:Phase Transition
D002021:Buffers; D007477:Ions; D007659:Ketones; D008738:Methyl Ethers; D000096:Acetone; C043243:methyl tert-butyl ether; D009249:NADP; D000426:Alcohol Dehydrogenase; C037075:2-octanone; D019840:2-Propanol