title: Serum antibody titres to canine parvovirus, adenovirus and distemper virus in dogs in the UK which had not been vaccinated for at least three years.
abstract: Antibody titres to canine distemper (CDV), canine parvovirus (CPV) and canine adenovirus (CAV) were measured in 144 adult dogs that had not been vaccinated for between three and 15 years. Protective antibodies to CPV were present in 95 per cent of the population, to CDV in 71.5 per cent and to CAV in 82 per cent. The prevalence of protective titres did not decrease with increasing time interval from the last vaccination for any of the three diseases studied. Booster vaccination increased the dogs CAV titres. For comparative purposes, 199 puppies were sampled at the time of their first and second vaccination. In the case of CPV and CAV a significantly higher proportion of the adult dogs were protected than of the puppies immediately after they were vaccinated. Natural CPV boosting was strongly suspected because the dogs had significantly higher titres three years after their primary vaccination than two weeks after it and three unvaccinated dogs had acquired protective antibody levels uneventfully. There was no evidence of natural exposure to CDV.
authors.affiliation: Queen's Veterinary School Hospital, Department of Clinical Veterinary Medicine, Madingley Road, Cambridge CB3 0ES.
authors.forename: M
authors.initials: M
authors.lastname: Böhm
authors.forename: H
authors.initials: H
authors.lastname: Thompson
authors.forename: A
authors.initials: A
authors.lastname: Weir
authors.forename: A M
authors.initials: AM
authors.lastname: Hasted
authors.forename: N S
authors.initials: NS
authors.lastname: Maxwell
authors.forename: M E
authors.initials: ME
authors.lastname: Herrtage
mesh_terms: D000257:Adenoviridae Infections / Q000276:immunology / Q000662:veterinary*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D004216:Distemper / Q000276:immunology*; D004283:Dog Diseases / Q000276:immunology* / Q000821:virology; D004285:Dogs; D005260:Female; D008297:Male; D010322:Parvoviridae Infections / Q000276:immunology / Q000662:veterinary*; D017993:Parvovirus, Canine; D013997:Time Factors; D006113:United Kingdom; D014611:Vaccination / Q000706:statistics & numerical data / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral