Sinus node function in patients with Brugada-type ECG.
BACKGROUND
Some studies have shown that patients with Brugada syndrome (BS) have atrioventricular conduction disturbance, but their sinus node function has not been evaluated.


RESULTS
The patients group consisted of 59 male patients and 1 female patient with BS. Supraventricular and ventricular programmed electrical stimulation (PES) was performed. Ventricular fibrillation (VF) or sustained polymorphic ventricular tachycardia was induced by ventricular PES in 26 patients with BS (VF group), but was not induced in the other 34 patients (non-VF group). Sinus node function and conduction of the atrioventricular (AV) node in the control group, non-VF group and VF group were evaluated. Sinus node function was attenuated and the His - ventricle interval was prolonged in the VF group (corrected sinus node recovery time: 452+/-126 ms (VF group), 324+/-146 ms (non-VF group), Sino-atrial conduction time: 179+/-60 ms (VF group), 127+/-60 ms (non-VF group), His-ventricle interval: 41+/-9 ms (VF group), 35+/-8 ms (non-VF group)).


CONCLUSIONS
The function of both the sinus node and AV node are attenuated in patients with PES-induced VF.
Morita
Hiroshi
H
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Okayama, Japan. hmorita@cc.okayama-u.ac.jp
Fukushima-Kusano
Kengo
K
Nagase
Satoshi
S
Miyaji
Kohei
K
Hiramatsu
Shigeki
S
Banba
Kimikazu
K
Nishii
Nobuhiro
N
Watanabe
Atsuyuki
A
Kakishita
Mikio
M
Takenaka-Morita
Shiho
S
Nakamura
Kazufumi
K
Saito
Hironori
H
Emori
Tetsuro
T
Ohe
Tohru
T
D000328:Adult; D001283:Atrioventricular Node / Q000503:physiopathology; D002037:Bundle-Branch Block / Q000175:diagnosis* / Q000503:physiopathology*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D011930:Reaction Time; D012849:Sinoatrial Node / Q000503:physiopathology*; D017180:Tachycardia, Ventricular / Q000209:etiology; D014693:Ventricular Fibrillation / Q000209:etiology