title: A PNA4 quadruplex.
abstract: A tetrameric PNA, TGGG, has been shown to form an intermolecular G-quadruplex. Nanoelectrospray mass spectrometry, combined with solution-phase H/D exchange, established formation of a specific tetramolecular complex. UV melting studies show that this complex undergoes a quadruplex melting transition. This is a novel four-stranded structure that offers the gross structural features of a DNA quadruplex, but without the negatively charged backbone.
authors.affiliation: University Chemical Laboratories, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
authors.forename: Yamuna
authors.initials: Y
authors.lastname: Krishnan-Ghosh
authors.forename: Elaine
authors.initials: E
authors.lastname: Stephens
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002942:Circular Dichroism; D017666:Deuterium Oxide; D005612:Freeze Drying; D006860:Hydrogen Bonding; D007202:Indicators and Reagents; D008968:Molecular Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D014466:Ultraviolet Rays
chemical_list: D007202:Indicators and Reagents; D020135:Peptide Nucleic Acids; D017666:Deuterium Oxide