title: A minimally invasive novel design for a vascular-pedicled bone segment for experimental studies of reconstruction of mandibular defects.
abstract: We describe a new minimally invasive vascularised bone segment (VBS) for experimental reconstruction of the mandible. The study was validated and the feasibility was tested on fresh sheep cadavers. The integrity of the arterial blood supply was confirmed using inferior dental artery static arteriography. A pilot investigation was conducted on two adult sheep. Two full thickness bone cuts 35 mm apart were created in the parasymphyseal region. The inferior dental neurovascular bundle was preserved at the posterior bone cut but not anteriorly. A VBS was created, pedicled only on the inferior dental artery. The continuity of the mandible was maintained using fixation plates and the animals were followed up for 12 weeks. There was complete bony union and restoration of approximately 80% of the bony strength. The model is minimally invasive, reduces the operating time, and does not require special equipment and skills in microvascular anastomosis.
authors.affiliation: Biotechnology and Craniofacial Research Group, Glasgow Dental Hospital & School and the West of Scotland Oral & Maxillofacial Surgery Service, University of Glasgow, Glasgow G2 3JZ, Scotland, UK.
authors.forename: Muammar M
authors.initials: MM
authors.lastname: Abu-Serriah
authors.forename: Ashraf F
authors.initials: AF
authors.lastname: Ayoub
authors.forename: Edward
authors.initials: E
authors.lastname: Odell
authors.forename: Stuart
authors.initials: S
authors.lastname: Carmichael
authors.forename: David
authors.initials: D
authors.lastname: Wray
mesh_terms: D000818:Animals; D001860:Bone Plates; D016025:Bone Transplantation / Q000379:methods*; D005240:Feasibility Studies; D008334:Mandible / Q000601:surgery*; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D023421:Models, Animal; D019647:Oral Surgical Procedures / Q000379:methods*; D019651:Plastic Surgery Procedures / Q000379:methods; D012756:Sheep; D034561:Sheep, Domestic; D013524:Surgical Flaps / Q000098:blood supply*; D020858:Tissue and Organ Harvesting