title: Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis.
abstract: Both coriatone (1). a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2). with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K(562) cells. They are cytotoxic with IC(50) > 50 microg/mL (cis-platinim: IC(50) = 0.49 microg/mL).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Liang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.forename: Qi-Tai
authors.initials: QT
authors.lastname: Zheng
mesh_terms: D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C494533:Coriatone; D007783:Lactones; D012717:Sesquiterpenes; C494534:corianlactone