Miconazole oral gel and drug interactions.
Miconazole oral gel is frequently prescribed for the treatment of oral Candidal infections. Its ability to be systemically absorbed and interact with other drugs has previously been recorded but is not universally known. As a reminder, a further case of derangement of anticoagulation following concomitant use of warfarin and miconazole is reported. Other potential drug interactions of miconazole and fluconazole are highlighted.
Pemberton
M N
MN
Oral and Maxillofacial Sciences, University Dental Hospital of Manchester, Higher Cambridge Street, Manchester M15 6FH, UK. Mike.Pemberton@man.ac.uk
Oliver
R J
RJ
Theaker
E D
ED
D000287:Administration, Topical; D000925:Anticoagulants / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004347:Drug Interactions; D005782:Gels; D006417:Hematuria / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008825:Miconazole / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D008875:Middle Aged; D014859:Warfarin / Q000009:adverse effects*
D000925:Anticoagulants; D000935:Antifungal Agents; D005782:Gels; D014859:Warfarin; D008825:Miconazole