title: The in vivo performance of a sol-gel glass and a glass-ceramic in the treatment of limited bone defects.
abstract: The in vivo evaluation, in New Zealand rabbits, of a SiO(2)-P(2)O(5)-CaO sol-gel glass and a SiO(2)-P(2)O(5)-CaO-MgO glass-ceramic, both bioactive in Kokubo's simulated body fluid (SBF), is presented. Bone defects, performed in the lateral aspect of distal right femoral epiphysis, 5mm in diameter and 4mm in depth, were filled with (i) sol-gel glass disks, (ii) glass-ceramic disks, or (iii) no material (control group). Each group included 8 mature and 8 immature rabbits. A 4-month radiographic study showed good implant stability without axial deviation of extremities in immature animals and periosteal growth and remodelling around and over the bone defect. After sacrifice, the macroscopic study showed healing of bone defects, with bone coating over the implants. The morphometric study showed a more generous bone formation in animals receiving sol-gel glass or glass-ceramic disks than in control group. Histomorphometric study showed an intimate union of the new-formed bone to the implants. This study allows considering both materials as eligible for bone substitution or repair. Their indications could include cavities filling and the coating of implant surfaces. The minimum degradation of glass-ceramic disks suggests its application in locations of load or transmission forces. As specific indication in growth plate surgery, both materials could be used as material of interposition after bony bridges resection.
authors.affiliation: Hospital Universitario Miguel Servet, Servicio de Cirugía Ortopédica y Traumatología, Universidad de Zaragoza, P Isabel La Católica 1-3, Zaragoza 50009, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Gil-Albarova
authors.forename: Ruth
authors.initials: R
authors.lastname: Garrido-Lahiguera
authors.forename: Antonio J
authors.initials: AJ
authors.lastname: Salinas
authors.forename: Jesús
authors.initials: J
authors.lastname: Román
authors.forename: Antonio L
authors.initials: AL
authors.lastname: Bueno-Lozano
authors.forename: Raúl
authors.initials: R
authors.lastname: Gil-Albarova
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005264:Femoral Fractures / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D020007:Implants, Experimental; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology*; D044367:Phase Transition; D011817:Rabbits; D011859:Radiography; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: C022107:Bioglass; D018786:Bone Substitutes; C439610:GC13 ceramic; D017886:Durapatite