title: Synthesis and glucose-6-phosphatase inhibitory activity of (thiouriedo)alkanoic acid esters.
abstract: A series of (3-pyridin-2-yl-thiouriedo)alkanoic acid esters (5a-j) have been synthesized by the reaction of pyridin-2-yl-dithiocarbamic acid methyl ester (2) and amino acid esters (4). Most of the synthesized compounds have been evaluated against glucose-6-phosphatase enzyme but only four compounds (5g-j) displayed significant inhibitory activity of the enzyme.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India.
authors.lastname: Farhanullah
authors.forename: Diptesh
authors.initials: D
authors.lastname: Sil
authors.forename: Brajendra K
authors.initials: BK
authors.lastname: Tripathi
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Srivastava
authors.forename: Vishnu Ji
authors.initials: VJ
authors.lastname: Ram
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004952:Esters / Q000138:chemical synthesis* / Q000494:pharmacology*; D005952:Glucose-6-Phosphatase / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D004952:Esters; D005952:Glucose-6-Phosphatase