title: Evaluation of BCRP and MDR-1 co-expression by quantitative molecular assessment in AML patients.
abstract: Expression of two MDR genes, BCRP and MDR1, was evaluated by real-time PCR technique in 51 AML patients. Fifty-six percent expressed the BCRP gene, with the 48.2% showing intermediate levels. Eighty-eight percent expressed the MDR1, with 23.8% of cases at high expression. A significant correlation between BCRP and MDR1 values was found by regression analysis. Either levels of BCRP or MDR1 did not correlate with clinical characteristics of patients at diagnosis.
authors.affiliation: Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, Ospedale S. Chiara, Via Roma, 56-56100 Pisa, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Galimberti
authors.forename: Francesca
authors.initials: F
authors.lastname: Guerrini
authors.forename: Giuseppe Alberto
authors.initials: GA
authors.lastname: Palumbo
authors.forename: Ugo
authors.initials: U
authors.lastname: Consoli
authors.forename: Rita
authors.initials: R
authors.lastname: Fazzi
authors.forename: Fortunato
authors.initials: F
authors.lastname: Morabito
authors.forename: Valeria
authors.initials: V
authors.lastname: Santini
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis* / Q000235:genetics; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis* / Q000235:genetics; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C116614:ABCG2 protein, human; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D012333:RNA, Messenger