title: Comparison of strength properties of normotensive and hypertensive rat pulmonary arteries.
abstract: A series of tests were conducted to quantify the difference in the mechanical properties of normo- and hypertensive pulmonary arteries. A bubble-test design was employed to measure the biaxial properties of a segment of artery. The test results compare the properties at multiple orientations of the trunk, right, and left pulmonary arteries from normal (Control) and monocrotaline-treated male Long-Evans wild rats that ranged in age from 8 to 17 weeks old, along with some preliminary results from hypoxic Long-Evans knock-out rats. Data show little difference between the stress-strain relationship of the control pulmonary arteries and that of the monocrotaline-treated pulmonary arteries. However, the preliminary results from the hypoxic pulmonary arteries show that the arterial material strains less before the onset of strain-stiffening behavior. The longitudinal orientation exhibits strain stiffening at lower strains than does the circumferential orientation. The differences between the left and right main arteries are minor. The trunk consistently demonstrates less stiffening in the region of larger strains for all conditions.
authors.affiliation: NIST, Materials Reliability Division, 325 Broadway, Boulder, CO 80305, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Drexler
authors.forename: C N
authors.initials: CN
authors.lastname: McCowan
authors.forename: J E
authors.initials: JE
authors.lastname: Wright
authors.forename: A J
authors.initials: AJ
authors.lastname: Slifka
authors.forename: D D
authors.initials: DD
authors.lastname: Ivy
authors.forename: R
authors.initials: R
authors.lastname: Shandas
mesh_terms: D000818:Animals; D019245:Compressive Strength; D004548:Elasticity; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D016686:Monocrotaline; D011651:Pulmonary Artery / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D020318:Rats, Long-Evans; D044023:Receptor, Endothelin B / Q000172:deficiency; D012016:Reference Values; D033081:Shear Strength; D013314:Stress, Mechanical; D013718:Tensile Strength
chemical_list: D044023:Receptor, Endothelin B; D016686:Monocrotaline