Synthesis of benzophenone oxime analogues as inhibitor of secretory phospholipase A(2) with anti-inflammatory activity.
The title compound have been synthesized and tested for structure activity relationship for Phospholipase A(2) (PLA(2)) [E.C. 3.1.1.4] enzyme inhibition. The in vitro PLA(2) enzyme inhibitory activity of benzophenone oxime analogue and in vivo anti-inflammatory activity studies using mice are highlighted.
Murari
Satish Kumar
SK
Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysore 570006, India.
Sriharsha
Shimoga Nagaraj
SN
Shashikanth
Sheena
S
Vishwanath
Bannikuppe Sannanaik
BS
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001577:Benzophenones; D004195:Disease Models, Animal; D004487:Edema / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D010091:Oximes / Q000138:chemical synthesis / Q000494:pharmacology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D001577:Benzophenones; D004791:Enzyme Inhibitors; D010091:Oximes; C047723:benzophenone; D010741:Phospholipases A