title: Celiac disease and lymphoma risk: a multicentric case--control study in Spain.
abstract: Celiac disease is a highly prevalent condition frequently misdiagnosed because of heterogeneity of the clinical symptoms. It is well recognized that enteropathy-associated T-cell lymphoma is an uncommon lymphoma type linked to celiac disease; it has also been suggested that other types of lymphomas may be associated with celiac disease. Our aim was to estimate the risk of all lymphoma associated with celiac disease. Serological markers and personal interviews were obtained from 298 consecutive lymphoma cases and 251 matched controls recruited in four Spanish hospitals. Celiac disease was detected in two cases (0.67%; n = 298) and in three controls (1.2%; n = 251). Treated celiac disease was observed in one patient with lymphoma and in two control subjects. In our series, there was no evidence that celiac disease was a risk factor for lymphoma (OR = 0.62, 95% CI = 0.10-3.79). Serological screening for CD is not recommended in people with lymphoma.
authors.affiliation: Hospital Sant Joan de Déu, Barcelona, Spain.
authors.forename: Carme
authors.initials: C
authors.lastname: Farré
authors.forename: Eva
authors.initials: E
authors.lastname: Domingo-Domenech
authors.forename: Rebeca
authors.initials: R
authors.lastname: Font
authors.forename: Teresa
authors.initials: T
authors.lastname: Marques
authors.forename: Alberto
authors.initials: A
authors.lastname: Fernandez de Sevilla
authors.forename: Tomas
authors.initials: T
authors.lastname: Alvaro
authors.forename: Mercedes Garcia
authors.initials: MG
authors.lastname: Villanueva
authors.forename: Vicens
authors.initials: V
authors.lastname: Romagosa
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjose
mesh_terms: D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology