title: Solid-phase synthesis of anandamide analogues.
abstract: The endocannabinoids are amides and esters of arachidonic acid that can mimic the pharmacological properties of Delta(9)-tetrahydrocannabinol (Delta(9)-THC). Anandamide, the most prominent of the endocannabinoids, has been implicated in both metabolic/physiological roles of the central nervous system, making it an attractive medicinal target. As such, we report the first solid-phase methodology that expedites access to various anandamide analogues. Our synthesis features a repetitive Cu-mediated coupling reaction between terminal alkynes and propargyl halides or allylic halides.
authors.affiliation: Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Longwu
authors.initials: L
authors.lastname: Qi
authors.forename: Michael M
authors.initials: MM
authors.lastname: Meijler
authors.forename: Sang-Hyeup
authors.initials: SH
authors.lastname: Lee
authors.forename: Chengzao
authors.initials: C
authors.lastname: Sun
authors.forename: Kim D
authors.initials: KD
authors.lastname: Janda