title: Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
authors.affiliation: Department of Biochemistry and Cambridge Centre for Molecular Recognition, 80 Tennis Court Road, Cambridge CB2 1GA, UK.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Gregory
authors.forename: Sabine
authors.initials: S
authors.lastname: Gaisser
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Lill
authors.forename: Hui
authors.initials: H
authors.lastname: Hong
authors.forename: Rose M
authors.initials: RM
authors.lastname: Sheridan
authors.forename: Barrie
authors.initials: B
authors.lastname: Wilkinson
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Petkovic
authors.forename: Alison J
authors.initials: AJ
authors.lastname: Weston
authors.forename: Isabelle
authors.initials: I
authors.lastname: Carletti
authors.forename: Huai-Lo
authors.initials: HL
authors.lastname: Lee
authors.forename: James
authors.initials: J
authors.lastname: Staunton
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
mesh_terms: D003001:Cloning, Molecular; D008401:Gas Chromatography-Mass Spectrometry; D005798:Genes, Bacterial / Q000235:genetics; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020123:Sirolimus / Q000031:analogs & derivatives / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; C488301:pre-rapamycin; D020123:Sirolimus