Harmaline induces different motor effects on facial vs. skeletal-motor systems in alert cats.
Harmaline's effects on reflex and classically conditioned eyelid responses and on tremor picked up by a coil attached to the back were measured in alert cats. Harmaline at a dose of 10 mg/kg produced skeletal muscle tremogenic effects that lasted 4h. Back movements presented a tremor-like displacement with a frequency peak at 10 Hz, but lid responses oscillated as in controls, at 20 Hz during both reflex and conditioned eyelid movements, with no increase in oscillation amplitude or frequency. The learning curves of harmaline-injected animals remained as in controls, but eyelid conditioned responses showed longer latencies, and smaller amplitude and peak velocity. Reflex and already-learned eyelid responses were not modified by harmaline. These results imply that neuronal control systems for skeletal-motor and facial responses are differentially affected by harmaline.
Morcuende
S
S
Division de Neurociencias, Laboratorio Andaluz de Biologia, Universidad Pablo de Olavide, Ctra. de Utrera, Km. 1, E41013-Sevilla, Spain.
Trigo
J A
JA
Delgado-García
J M
JM
Gruart
A
A