title: Human imaging of phosphorus in cortical and trabecular bone in vivo.
abstract: Phosphorus was imaged in vivo in human cortical and trabecular bone and the T(1) and T(2) (*) were measured. An ultrashort TE (UTE) pulse sequence (TE = 70 microm) was used with half pulse excitation and radial mapping of k-space from the center out. T(2) (*) was measured using multiple echo times and T(1) was measured both by saturation recovery and by a method using different RF pulse amplitudes. Seven normal subjects (32-85 years) were examined. Phosphorus was imaged, with a true in-plane resolution of 2.9 x 2.9 mm and a signal-to-noise ratio (SNR) of 19:1, in both cortical and trabecular bone. The mean T(2) (*) value was 207 +/- 12 micros, and the mean T(1) value was 8.6 +/- 3.0 sec. Images and measurements were obtained in realistic times on a clinical MR system. This may provide a new approach to characterizing disease of bone.
authors.affiliation: University of Oxford Centre for Clinical Magnetic Resonance Research, MRS Unit, John Radcliffe Hospital, Oxford, UK. matthew.robson@bioch.ox.ac.uk
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Robson
authors.forename: Peter D
authors.initials: PD
authors.lastname: Gatehouse
authors.forename: Graeme M
authors.initials: GM
authors.lastname: Bydder
authors.forename: Stefan
authors.initials: S
authors.lastname: Neubauer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010758:Phosphorus / Q000032:analysis*
chemical_list: D010758:Phosphorus