title: [The study of yi-shen-huo-xue fang's effects on expression of GMP-140 and cleaning out the oxygenic free radicle on rabbits blood stasis model].
abstract: OBJECTIVE
  To evaluate the effects of Yi-Shen-Huo-Xue Fang on expression of GMP-140 and cleaning out the oxygenic free radicle on rabbits blood stasis model.
  
  
  METHODS
  Thirty rabbits were divided randomly into five groups as the normal group, model group, large dose of "Yi-Shen-Huo-Xue Fang" group, small dose of "Yi-Shen-Huo-Xue Fang" group and "Xue-Shuan-Xin-Mai-Ning" group. After being treated respectively, granule membrane protein 140(GMP-140), erythrocyte sueroxide dismutase (E-SOD), erythrocyte lipid peroxide(E-LPO), plasma lipid peroxide(P-LPO) were checked up.
  
  
  RESULTS
  The GMP-140, E-SOD, E-LPO, P-LPO in normal control were compared with those in model groups, With the difference(P < 0.01), model control group was compared with large dose group and small dose group (P < 0.01), with "Xue-Shuan-Xin-Mai-Ning" group(P < 0.05), large dose group was compared with "Xue-Shuan-Xin-Mai-Ning" group(P < 0.05), and large dose group were compared with small dose group (P > 0.05).
  
  
  CONCLUSIONS
  The model was made successfully. Large dose group, small dose group and "xue-shuan-xin-mai-ning" group can inhibit expression of GMP-140, enhence SOD activity and decrease LPO content on blood stasis rabbit model. Large dose group and small dose group have stronger effect than "xue-shuan-xin-mai-ning" group.
authors.affiliation: Second Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang, China.
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Zhan
authors.forename: Qing
authors.initials: Q
authors.lastname: Fang
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Lou
authors.forename: Xi-hong
authors.initials: XH
authors.lastname: Xu
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Jin
authors.forename: Guang-ming
authors.initials: GM
authors.lastname: Qin
authors.forename: Jun
authors.initials: J
authors.lastname: Bao
mesh_terms: D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008516:Medicine, Chinese Traditional; D019007:P-Selectin / Q000096:biosynthesis*; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D011897:Random Allocation; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D019007:P-Selectin; D013482:Superoxide Dismutase