title: First practical protection of alpha-amino acids as N,N-benzyloxycarbamoyl derivatives.
abstract: The consecutive treatment of N-Cbz amino protected compounds with LiHMDS and CbzCl provides a practical method for the preparation of N,N-benzyloxycarbamoyl (N,N-di-Cbz) derivatives in good yield. When alpha-amino acids are used the protection occurs without racemization. The method is compatible with a wide range of other functional and protecting groups. The procedure is also valid for the synthesis of mixed N,N-carbamoyl derivatives.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez, 2, 38206 La Laguna, Tenerife, Spain.
authors.forename: J Nicolás
authors.initials: JN
authors.lastname: Hernández
authors.forename: Víctor S
authors.initials: VS
authors.lastname: Martín