title: Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists.
abstract: A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are discussed.
authors.affiliation: Department of Medicinal Chemistry, GlaxoSmithKline, RTP, NC 27709, USA. cja9377@gsk.com
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Aquino
authors.forename: Joshi M
authors.initials: JM
authors.lastname: Ramanjulu
authors.forename: Dennis
authors.initials: D
authors.lastname: Heyer
authors.forename: Alejandro J
authors.initials: AJ
authors.lastname: Daniels
authors.forename: Fabio
authors.initials: F
authors.lastname: Palazzo
authors.forename: Milana
authors.initials: M
authors.lastname: Dezube
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D011869:Radioligand Assay; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D006146:Guanidines; D017476:Receptors, Neuropeptide Y; C100568:neuropeptide Y5 receptor