title: The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats.
abstract: Effects of three different varieties (Koimidori, Powerful-Reishi, and Hyakunari) of bitter melon (Momordica charantia) and those of methanol fraction extract of Koimidori variety on serum and liver triglycerides were studied in rats. Feeding of diets containing either bitter melon or various fractions isolated by organic solvents caused no adverse effects on food intake or growth of rats. When the effect of three different varieties of bitter melon was compared, the Koimidori variety was found to be the most effective in lowering hepatic triglyceride levels as compared to the other two varieties, suggesting a variety-dependent difference in their activity. Furthermore, the active component(s) responsible for the liver triglyceride lowering activity of Koimidori variety was assumed to be concentrated in the methanol fraction, but not in other fractions such as the n-hexane, the acetone, or the residual fraction. The triglyceride lowering activity was furthermore confirmed by the dose-dependent reduction of hepatic triglyceride, resulting the lowest level in rats fed 3.0% supplementation. In these experiments, the effects on serum lipids were marginal. The results of the present and previous studies clearly show that bitter melon, especially Koimidori variety, exhibits a potent liver triglyceride-lowering activity.
authors.affiliation: Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
authors.forename: Gamarallage V K
authors.initials: GV
authors.lastname: Senanayake
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Maruyama
authors.forename: Kei
authors.initials: K
authors.lastname: Shibuya
authors.forename: Masanobu
authors.initials: M
authors.lastname: Sakono
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Fukuda
authors.forename: Toshiro
authors.initials: T
authors.lastname: Morishita
authors.forename: Chizuko
authors.initials: C
authors.lastname: Yukizaki
authors.forename: Mikio
authors.initials: M
authors.lastname: Kawano
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ohta
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D029777:Momordica charantia; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
chemical_list: D000960:Hypolipidemic Agents; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol