Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence-based typing.
This report describes the identification of a novel DPB1 allele, DPB *9701, found in an Italian Caucasian individual. The new allele was detected by human leukocyte antigen sequence-based typing carried out to investigate the role of genetic factors in determining the outcome of hepatitis C virus infection. DPB1*9701 was identical to DPB1*0501 except for a single-nucleotide substitution at codon 43 (GGG --> TGG). This nucleotide change is a non-synonymous mutation and results in the amino acid substitution glycine (G) --> tryptophan (W). The nucleotide sequence has been deposited in GenBank under the accession number AY033075, and denominated DPB1*9701 by the official World Health Organization Nomenclature Committee.
Lapi
S
S
Laboratory of Immunogenetics, Immunoemathology II Unit, Cisanello Hospital, Pisa, Italy. s.lapi@ao-pisa.toscana.it
Curcio
M
M
Fornaciari
S
S
Mariotti
M L
ML
Isola
P
P
Bonci
F
F
Pistello
M
M
Scatena
F
F
D001483:Base Sequence; D006682:HLA-DP Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; C495079:HLA-DPB1*97:01 antigen