title: [Studies on paclitaxel-loaded nanoparticles of amphiphilic block copolymer].
abstract: OBJECTIVE
  To investigate the paclitaxel-loaded nanoparticles of poly(ethylene glycol)-b-poly(D,L-lactic acid) amphiphilic diblock copolymer (PMT).
  
  
  METHODS
  PMT was prepared by solid dispersion technique. The average size and size distribution were determined by dynamic light scattering (DLS). The morphology was characterized by transmission electron microscopy (TEM) and 1HNMR. The influences of the copolymer molecular weight and the paclitaxel-fed amount on PMT were studied. Therapeutic effect of PMT was studied on Kunming mice liver cancer H22.
  
  
  RESULTS
  PMT showed nanometer size and spherical morphology with core and shell. The sizes of PMT increased with increasing the molecular weight of the hydrophobic segment in PEDLLA or increasing the drug-loaded amount. The tumour inhibiting effect of PMT was similar with that of Taxol.
  
  
  CONCLUSIONS
  It will provide an experiment basis for the development of new kind of intravenous administration of paclitaxel.
authors.affiliation: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China. ajdong@tju.edu.cn
authors.forename: An-jie
authors.initials: AJ
authors.lastname: Dong
authors.forename: Lian-dong
authors.initials: LD
authors.lastname: Deng
authors.forename: Duo-xian
authors.initials: DX
authors.lastname: Sun
authors.forename: Yue-ting
authors.initials: YT
authors.lastname: Zhang
authors.forename: Jian-zhou
authors.initials: JZ
authors.lastname: Jin
authors.forename: Ying-jin
authors.initials: YJ
authors.lastname: Yuan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D019344:Lactic Acid; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D008863:Microspheres; D036103:Nanotechnology; D017239:Paclitaxel / Q000008:administration & dosage* / Q000494:pharmacology; D010316:Particle Size; D011092:Polyethylene Glycols
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D019344:Lactic Acid; D011092:Polyethylene Glycols; D017239:Paclitaxel