Thalidomide in POEMS syndrome: case report.
We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of thalidomide, a drug with known anti-angiogenetic, anti-proliferative, and anti-cytokine properties.
Sinisalo
Marjatta
M
Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. marjatta.sinisalo@pshp.fi
Hietaharju
Aki
A
Sauranen
Jukka
J
Wirta
Ole
O
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008875:Middle Aged; D016878:POEMS Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
D020533:Angiogenesis Inhibitors; D013792:Thalidomide