title: Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography.
abstract: Induced haemodynamic and blood oxygenation changes occurring within the brain of a ventilated newborn infant have been imaged in three dimensions using optical tomography. Noninvasive measurements of the flight times of transmitted light were acquired during illumination of the brain by laser pulses at wavelengths of 780 nm and 815 nm. The oxygen and carbon dioxide partial pressures were adjusted through alterations to the ventilator settings, resulting in changes to the cerebral blood volume and oxygenation. Three-dimensional images were generated using the physiologically associated differences in the measured data, obviating the need for data calibration using a separate reference measurement. The results exhibit large changes in absorption coefficient at both wavelengths. Images corresponding to differences in concentrations of oxy- and deoxyhaemoglobin are in qualitative agreement with known physiological data.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, 11-20 Capper Street, London WC1E 6JA, UK.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Hebden
authors.forename: Adam
authors.initials: A
authors.lastname: Gibson
authors.forename: Topun
authors.initials: T
authors.lastname: Austin
authors.forename: Rozarina Md
authors.initials: RM
authors.lastname: Yusof
authors.forename: Nick
authors.initials: N
authors.lastname: Everdell
authors.forename: David T
authors.initials: DT
authors.lastname: Delpy
authors.forename: Simon R
authors.initials: SR
authors.lastname: Arridge
authors.forename: Judith H
authors.initials: JH
authors.lastname: Meek
authors.forename: John S
authors.initials: JS
authors.lastname: Wyatt
mesh_terms: D001783:Blood Flow Velocity; D001811:Blood Volume Determination / Q000379:methods*; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005323:Fetal Monitoring / Q000379:methods*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis* / Q000503:physiopathology; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D010100:Oxygen