New beauvericins, potentiators of antifungal miconazole activity, Produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation and biological properties.
Three new beauvericins, designated beauvericins D, E and F, were isolated along with known beauvericin and beauvericin A, from the culture of Beauveria sp. FKI-1366 by solvent extraction, ODS column chromatography and HPLC. These compounds potentiate miconazole activity against not only wild Candida albicans but also fluconazole resistant C. albicans. Beauvericins D and E decreased the IC50 value of miconazole against fluconazole resistant C. albicans from 1.3 microM to 0.25 and 0.31 microM, respectively.
Fukuda
Takashi
T
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Arai
Masayoshi
M
Yamaguchi
Yuichi
Y
Masuma
Rokurou
R
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000935:Antifungal Agents / Q000096:biosynthesis / Q000494:pharmacology*; D001203:Ascomycota / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D025141:Drug Resistance, Fungal; D004357:Drug Synergism; D005285:Fermentation; D015725:Fluconazole / Q000494:pharmacology; D018942:Macrolides / Q000378:metabolism / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning
D000935:Antifungal Agents; D047630:Depsipeptides; D018942:Macrolides; C485086:beauvericin D; C485087:beauvericin E; C485088:beauvericin F; D008825:Miconazole; D015725:Fluconazole