Polarographic behaviors of diclofenac sodium in the presence of dissolved oxygen and its analytical application.
The polarographic response characteristics of diclofenac sodium were investigated in 0.25 M HAc-NaAc (pH 5.0) supporting electrolyte in the absence and the presence of dissolved oxygen. The results demonstrate that the reduction peak at ca. -1.10 V is a catalytic hydrogen wave after deaeration, and the reduction peak in the presence of dissolved oxygen is a so-called parallel catalytic hydrogen wave. Based on the parallel catalytic hydrogen wave, a novel method has been proposed for the determination of diclofenac sodium by single-sweep polarography. The calibration curve is linear in the range 1.2 x 10(-7)-2.6 x 10(-6)M and the detection limit is 6.0 x 10(-8)M. The proposed method is applied to the direct determination of diclofenac sodium in tablet forms and biological samples.
Xu
Maotian
M
Institute of Analytical Science, Northwest University, Xi'an 710069, People's Republic of China.
Chen
Liangfeng
L
Song
Junfeng
J
D002021:Buffers; D002138:Calibration; D002384:Catalysis; D004008:Diclofenac / Q000032:analysis* / Q000737:chemistry*; D004573:Electrolytes; D006859:Hydrogen; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D011048:Polarography; D012680:Sensitivity and Specificity
D002021:Buffers; D004573:Electrolytes; D004008:Diclofenac; D006859:Hydrogen; D010100:Oxygen