title: Multiple roles of canonical Wnt signaling in cell cycle progression and cell lineage specification in neural development.
abstract: Signaling by the canonical Wnt pathway has multiple functions in stem cells. It can either control stem cell expansion or--as we have recently demonstrated with neural crest stem cells-influence cell lineage decisions by promoting specific fates at the expense of others. Thus, the role of canonical Wnt in stem cells is dependent on cell--intrinsic properties that determine how a cell responds to Wnt. The molecular basis for the functional diversity of Wnt in different stem cell types remains to be elucidated.
authors.affiliation: Institute of Cell Biology, Department of Biology, ETH-Hönggerberg, Zurich, Switzerland. sommer@cell.biol.ethz.ch
authors.forename: Lukas
authors.initials: L
authors.lastname: Sommer
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D009474:Neurons / Q000166:cytology*; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins
chemical_list: D018797:Cell Cycle Proteins; D036341:Intercellular Signaling Peptides and Proteins; D051153:Wnt Proteins