[Peripheral neuropathy and myositis in idiopathic hypereosinophilic syndrome: case report].
We describe a case of idiopathic hypereosinophilic syndrome manifested by an axonal sensory-motor polyneuropathy (ASMP) and signals of myositis. A 20 year old woman began with progressive gait impairment with drops and presented with subacute lower limb edema associated with paresthesis and cramps. She showed hypotonia in the lower limbs, absence of knee and ankle jerks, steppage gait, and decreased sensation on both legs. Examinations of stools were negative. Blood examination showed 7700 leukocytes with 24% (1848/mm(3)) eosinophils. Electrodiagnostic studies showed axonal lesion in sensory and motor nerves. Muscle biopsy showed type 2 muscle fibers atrophy with discrete inflammatory cells, predominantly lymphocytic in perivascular and interstitial locations. She was treated with prednisone and all the symptoms subsided after two months.
Scola
Rosana Herminia
RH
Serviço de Doença Neuromuscular e Neurologia, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brazil. scola@hc.ufpr.br
Trentin
Ana Paula
AP
Fabiani
Giorgio
G
Mücke
Denilson
D
Werneck
Lineu Cesar
LC
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004576:Electromyography; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D009220:Myositis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011241:Prednisone