[Current data on granulocytes donations].
Granulocyte transfusion is uncommon but essential for some aplastic patients with major infection and those with septic granulomatosis disease and visceral aspergillosis. Compatibility between donor and recipient (ABO, D, Kell blood type, cytomegalovirus) is necessary. Stimulation by dexamethasone, before use of GCSF, permits to obtain approximately 10 x 10(9) white cells per l. Doses of heparin must be calculated to ensure an efficient hypocoagulation without any trouble for the donor immediately after his donation. Sedimentation by hydroxyethylstarch is an unavoidable element to obtain the most efficient separation of granulocytes. Most donations present an amount of white cells between 2 and 4 10 x 10(10). This enables to transfuse efficiently children and adults.
de Talancé
D Lemau
DL
Site Lecourbe, EFS-Ile-de-France, 20, rue Lecourbe 75015 Paris, France.
Benomar
D
D
Boulat
C
C
Beaumont
J-L
JL
D000328:Adult; D000380:Agranulocytosis / Q000628:therapy; D000925:Anticoagulants / Q000008:administration & dosage; D001780:Blood Coagulation Tests; D001782:Blood Donors / Q000706:statistics & numerical data*; D001788:Blood Grouping and Crossmatching; D002469:Cell Separation / Q000379:methods; D002498:Centrifugation; D002648:Child; D003586:Cytomegalovirus Infections / Q000453:epidemiology; D003907:Dexamethasone / Q000494:pharmacology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006098:Granulocytes; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007937:Leukapheresis / Q000379:methods; D007958:Leukocyte Count; D017708:Leukocyte Transfusion / Q000706:statistics & numerical data*; D012449:Safety
D000925:Anticoagulants; D006895:Hydroxyethyl Starch Derivatives; D016179:Granulocyte Colony-Stimulating Factor; D003907:Dexamethasone; D006493:Heparin