Drug-induced and toxic myopathies.
Drug-induced myopathies and, more rarely, rhabdomyolysis, are a common biological and clinical setting for clinical rheumatologists. The focus of this chapter is to review (i) the clinical presentation and management of these adverse drug reactions (ADR) according to pain and associated neurological symptoms, (ii) the common drugs prescribed by rheumatologists which may induce reactions such as ADR, with special reference to new drugs, (iii) the pathological classification associated with specific patterns, and (iv) the risk factors leading to myotoxicity (including genetic predisposition). Specific features to be reviewed include macrophage myofasciitis and biological agents of major importance when considering terrorist attacks with biological weapons. When diagnosis is suspected, discontinuation of the putative drug(s) is mandatory and should be carefully monitored.
Guis
Sandrine
S
Service de Rhumatologie Est Pr Roudier, Hôpital de la Conception, 147 bd Baille, 13005 Marseille, France.
Mattéi
Jean-Pierre
JP
Lioté
Frédéric
F
D006801:Humans; D009135:Muscular Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000628:therapy