RNA: primed for packing?
How does RNA's seemingly subtle 2'-hydroxyl group contribute to its diverse biological functions? Using quantitative structure-activity relationship (QSAR) analysis, Piccirilli and colleagues find that the 2'-OH fosters van der Waals and hydrophobic interactions that play underappreciated roles in RNA structure and molecular recognition.
Karbstein
Katrin
K
Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720, USA.
Doudna
Jennifer A
JA
D017665:Hydroxyl Radical; D012313:RNA / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*; D013329:Structure-Activity Relationship
D017665:Hydroxyl Radical; D012313:RNA