[Pathologic diagnosis and differential diagnosis of pulmonary Langerhans' cell histiocytosis].
OBJECTIVE
Morphologic findings of pulmonary Langerhans' cell histiocytosis were analyzed in order to delineate diagnostic features.


METHODS
H&E staining and immunohistochemical studies were performed on 7 cases of pulmonary Langerhans' cell histiocytosis.


RESULTS
Infiltration by Langerhan's cells was obvious in all 7 cases. Inflammatory cell infiltrates, interstitial fibrosis and focal necrosis may also be seen. The cells expressed S-100 (7/7), CD68 (3/7), and CD1a (5/5).


CONCLUSIONS
In case there is radiologic suspicion of Langerhans' cell histiocytosis, pulmonary biopsy is strongly advised for a definitive diagnosis. S-100 and CD1a immunostaining is also helpful in this respect.
Li
Ji
J
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Liu
Hong-rui
HR
Guo
Li-na
LN
D000293:Adolescent; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1 / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007801:Langerhans Cells / Q000737:chemistry; D008168:Lung / Q000473:pathology*; D008297:Male; D009418:S100 Proteins / Q000032:analysis; D000097382:CD68 Molecule
D015703:Antigens, CD; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic; D009418:S100 Proteins; C419393:CD1a antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule