Heavier-than-air flying machines are impossible.
Many G protein-coupled receptor (GPCR) models have been built over the years. The release of the structure of bovine rhodopsin in August 2000 enabled us to analyze models built before that period to learn more about the models we build today. We conclude that the GPCR modelling field is riddled with 'common knowledge' similar to Lord Kelvin's remark in 1895 that "heavier-than-air flying machines are impossible", and we summarize what we think are the (im)possibilities of modelling GPCRs using the coordinates of bovine rhodopsin as a template. Associated WWW pages: www.gpcr.org/articles/2003_mod
Oliveira
L
L
Escola Paulista de Medicina, Sao Paulo, Brazil.
Hulsen
T
T
Lutje Hulsik
D
D
Paiva
A C M
AC
Vriend
G
G
D000595:Amino Acid Sequence; D000818:Animals; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000235:genetics; D012243:Rhodopsin / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment
D043562:Receptors, G-Protein-Coupled; D012243:Rhodopsin