[Haemodialysis, L-carnitine therapy and valproic acid overdose].
We report the case of a severe valproic acid poisoning in a 36-year-old man. In front of a high serum concentration of valproic acid at the admission, haemodialysis was initiated to decrease serum valproic acid concentration. A L-carnitine therapy (50 mg/kg per day) was also started. A cerebral oedema appeared at the third day, but the patient recovered without any sequela.
Minville
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V
Département d'anesthésie réanimation, hôpital de Rangueil, CHU de Toulouse, 31403 Toulouse cedex 04, France. vincentminville@yahoo.fr
Roche Tissot
C
C
Samii
K
K
D000328:Adult; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use*; D001929:Brain Edema / Q000139:chemically induced / Q000503:physiopathology; D002331:Carnitine / Q000627:therapeutic use*; D062787:Drug Overdose; D006801:Humans; D008297:Male; D006435:Renal Dialysis; D013406:Suicide, Attempted; D014635:Valproic Acid / Q000097:blood / Q000506:poisoning*
D000927:Anticonvulsants; D000931:Antidotes; D014635:Valproic Acid; D002331:Carnitine