[Clinical analysis of endometrial carcinoma patients aged 45 years and younger].
OBJECTIVE
To retrospectively analyze the clinical characteristics and outcomes of endometrial carcinoma patients aged 45 years and younger.


METHODS
Fifty-two cases of endometrial carcinoma aged 45 years and younger were treated in Peking Union Medical College Hospital. They were further divided into group A (35 years of age and younger) and group B (older than 35 years). Clinical data of these patients were reviewed and the two groups were compared.


RESULTS
Patients aged 45 years and younger accounted for 12.7% of all the endometrial carcinoma cases. About 50% of the patients were nulliparous, infertile or had irregular menstruation and endometrial hyperplasia, 29% were obese, 23% had polycystic ovaries. Eighty-three percent of the patients were stage [International Federation of Gynecology and Obstetrics (FIGO), 1988]. Group A had more polycystic ovaries and atypical endometrial hyperplasia than group B (53% vs 9%, 59% vs 26% respectively, P < 0.05). All group A patients were stage I endometrial carcinoma. In group B, 26% had high risk factors, and compared with group A, FIGO stage was higher (P < 0.05). Operation was the main treatment. Two patients were treated successfully with conservative high dose progestin. Two patients relapsed.


CONCLUSIONS
There were high incidences of infertility, irregular menstruation, endometrial hyperplasia, obese and polycystic ovaries in patients aged 45 years and younger, indicating the relationship between endometrial carcinoma and estrogen. Most patients, especially those younger than 35 years, were stage I with few risk factors and good prognosis. Conservation of fertility and ovarian function should be considered in these patients.
Gao
Jin-song
JS
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Shen
Keng
K
Lang
Jing-he
JH
Huang
Hui-fang
HF
Pan
Ling-ya
LY
Wu
Ming
M
Jin
Ying
Y
Chen
Qiong-hua
QH
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D018262:Adenocarcinoma, Clear Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000367:Age Factors; D002681:China; D004714:Endometrial Hyperplasia / Q000209:etiology; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011085:Polycystic Ovary Syndrome / Q000209:etiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors