A novel der(12)t(7;12)(p15;q24.3) in a patient with childhood T-cell acute lymphoblastic leukemia.
Approximately 35% of T-cell acute lymphoblastic leukemia (T-ALL) cases have chromosomal translocations as evaluated by conventional cytogenetic methods (G-banding). Some chromosomal translocations are associated with morphologically and immunophenotypically distinct leukemia subtypes and define patients with different clinical outcomes. Chromosomal translocations may deregulate gene expression, thus contributing to the development of neoplasia, either by placing a putative oncogene under the control of strong regulatory elements or by generating chimeric genes and oncogenic fusion proteins. We report here a novel der(12)t(7;12)(p15;q24.3) in a child with T-ALL. Cloning and characterization of the breakpoint region may contribute to the discovery of new genes that are important in T-ALL.
de Freitas
Fernando Augusto
FA
Laboratório de Biologia Molecular, Centro Infantil Boldrini, Rua Gabriel Porto 1270, 13083-210 Campinas, SP, Brazil.
Girotto Zambaldi
Lilian de Jesus
Lde J
de Araujo
Marcela
M
Gatti
Emerson
E
Otubo
Rosemary
R
Tsuchiya
Mathilde Rie
MR
Matsuda
Eduardo Ioshiteru
EI
Brandalise
Silvia Regina
SR
Yunes
José Andrés
JA
D002675:Child, Preschool; D002881:Chromosomes, Human, Pair 12; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic