Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices.
Enediyne model compounds possessing photo-triggering devices were developed. These enediynes afforded biradicals by UV irradiation and showed DNA cleaving activity. The DNA damage was confirmed to be mainly caused by the biradical, not singlet oxygen.
Suzuki
Ichiro
I
Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi 1-78, Tokushima, Japan. isuzuki@ph.tokushima-u.ac.jp
Uno
Shinsaku
S
Tsuchiya
Yuko
Y
Shigenaga
Akira
A
Nemoto
Hisao
H
Shibuya
Masayuki
M
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects; D053281:Enediynes; D005609:Free Radicals; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects; D009574:Nitro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010782:Photolysis; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000528:radiation effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
D000480:Alkynes; D053281:Enediynes; D005609:Free Radicals; D006841:Hydrocarbons, Aromatic; D009574:Nitro Compounds; D017319:Photosensitizing Agents; D011743:Pyrimidines; C418567:enediynone