Oxidation of isoniazid by quinolinium dichromate in an aqueous acid medium and kinetic determination of isoniazid in pure and pharmaceutical formulations.
The kinetics of oxidation of isoniazid in acidic medium was studied spectrophotometrically. The reaction between QDC and isoniazid in acid medium exhibits (4:1) stoichiometry (QDC:isoniazid). The reaction showed first order kinetics in quinolinium dichromate (QDC) concentration and an order of less than unity in isoniazid (INH) and acid concentrations. The oxidation reaction proceeds via a protonated QDC species, which forms a complex with isoniazid. The latter decomposes in a slow step to give a free radical derived from isoniazid and an intermediate chromium(V), which is followed, by subsequent fast steps to give the products. The reaction constants involved in the mechanism are evaluated. Isoniazid was analyzed by kinetic methods in pure and pharmaceutical formulations.
Kulkarni
Raviraj M
RM
P. G. Department of Chemistry, Karnatak University, Dharwad-580 003, India.
Bilehal
Dinesh C
DC
Nandibewoor
Sharanappa T
ST
D000465:Algorithms; D002626:Chemistry, Pharmaceutical; D002840:Chromates / Q000737:chemistry*; D007202:Indicators and Reagents; D007538:Isoniazid / Q000737:chemistry*; D007700:Kinetics; D011804:Quinolines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets; D013696:Temperature
D002840:Chromates; D007202:Indicators and Reagents; D011804:Quinolines; D013607:Tablets; D007538:Isoniazid