Peripheral substituents of di(pyridiumyl)porphyrins affected on their interactions with DNA.
meso- and beta-Substituted di(pyridiumyl)porphyrins 3, 4, and 7 have been synthesized and their interactions with DNA have been investigated. meso-Substituted porphyrins showed the stronger effect on DNA than that of beta-substituted porphyrin. Cytotoxicity of compound 3 (IC(50)) to THP-1 tumor cell was up to 0.11 nM.
Wu
Song
S
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.
Wang
Ping
P
Tian
Tian
T
Wu
Lin
L
He
Hanping
H
Zhou
Xiang
X
Zhang
Xiaolian
X
Cao
Xiaoping
X
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D010782:Photolysis; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D011166:Porphyrins; D011726:Pyridinium Compounds; C445064:di-(N-methylpyridinium-3-yl)porphyrin; D004247:DNA