title: Management of Eisenmenger syndrome in pregnancy with sildenafil and L-arginine.
abstract: BACKGROUND
  Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options.
  
  
  METHODS
  We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with L-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being.
  
  
  CONCLUSIONS
  The concomitant use of sildenafil and L-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant.
authors.affiliation: Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: Héctor J
authors.initials: HJ
authors.lastname: Lacassie
authors.forename: Alfredo M
authors.initials: AM
authors.lastname: Germain
authors.forename: Gloria
authors.initials: G
authors.lastname: Valdés
authors.forename: M Soledad
authors.initials: MS
authors.lastname: Fernández
authors.forename: Francisco
authors.initials: F
authors.lastname: Allamand
authors.forename: Héctor
authors.initials: H
authors.lastname: López
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000328:Adult; D001120:Arginine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004541:Eisenmenger Complex / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D010348:Patient Care Team; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D001120:Arginine; D000068677:Sildenafil Citrate; D015106:3',5'-Cyclic-GMP Phosphodiesterases