title: Clinical evaluation and treatment of the adult patient with suspected primary immunodeficiency disease: a case analysis.
abstract: OBJECTIVE
  To describe immunoglobulin G2 (IgG2) subclass deficiency in the context of primary immunodeficiency disorders, their pathophysiology, epidemiology, clinical evaluation, and management.
  
  
  METHODS
  Actual case study and extensive review of the scientific and medical literature.
  
  
  CONCLUSIONS
  Consideration should be given to primary immunodeficiency diseases as one possible cause of recurrent upper and lower respiratory tract infections in patients at any age. Early diagnosis and intervention can significantly reduce the burden of these diseases.
  
  
  CONCLUSIONS
  Advanced practice nurses need to keep pace with the ever-expanding field of immunity. Knowledge of basic principles of the immune system facilitates a logical approach to the evaluation and management of primary immunodeficiency diseases.
authors.affiliation: Mercy Health Center, Allergy and Immunology Clinic, Pittsburgh, Pennsylvania, USA. dciesielka@clarion.edu
authors.forename: Debbie
authors.initials: D
authors.lastname: Ciesielka
mesh_terms: D000368:Aged; D003663:Decision Trees; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000276:immunology* / Q000451:nursing*; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000451:nursing / Q000503:physiopathology; D009722:Nurse Practitioners / Q000592:standards*; D015404:Nursing Methodology Research; D012141:Respiratory Tract Infections / Q000276:immunology; D013997:Time Factors