title: Drug-induced cardiac toxicity: emphasizing the role of electrocardiography in clinical research and drug development.
abstract: This review describes the role of electrocardiography in clinical research and drug development, and addresses its utility in defining cardiac toxicity from noncardiac investigational drugs. Principles for designing electrocardiographic monitoring for cardiac safety in clinical trials are also reviewed.
authors.affiliation: igussak@ert.com
authors.forename: Ihor
authors.initials: I
authors.lastname: Gussak
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Litwin
authors.forename: Robert
authors.initials: R
authors.lastname: Kleiman
authors.forename: Scott
authors.initials: S
authors.lastname: Grisanti
authors.forename: Joel
authors.initials: J
authors.lastname: Morganroth
mesh_terms: D002986:Clinical Trials as Topic; D004341:Drug Evaluation / Q000331:legislation & jurisprudence / Q000592:standards* / Q000639:trends; D015507:Drugs, Investigational / Q000009:adverse effects*; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006331:Heart Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control; D006801:Humans; D012106:Research / Q000331:legislation & jurisprudence / Q000592:standards / Q000639:trends
chemical_list: D015507:Drugs, Investigational