Toward a molecular genetic classification of familial hemiplegic migraine.
The genetics of migraine is a fascinating and rapidly moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene or in the chromosome 1 ATP1A2 gene. Familial migraine variants are classified on the basis of clinical, descriptive criteria, but this is insufficient. In the future, a diagnostic classification based on mutation-analysis is needed.
Haan
Joost
J
Department of Neurology (K5Q), Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.
Kors
Esther E
EE
van den Maagdenberg
Arn M J M
AM
Vanmolkot
Kaate R J
KR
Terwindt
Gisela M
GM
Frants
Rune R
RR
Ferrari
Michel D
MD
D006801:Humans; D020325:Migraine with Aura / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics
C498531:ATP1A2 protein, human; D000254:Sodium-Potassium-Exchanging ATPase