title: Keratoacanthoma centrifugum marginatum: a diagnostic and therapeutic challenge.
abstract: A keratoacanthoma centrifugum marginatum (KACM) may pose a diagnostic and therapeutic challenge. Clinically and histologically, it may resemble mycobacterial or deep fungal infection or halogenoderma. Therapy can be challenging because the lesion can expand to a great size. We report on a patient with multiple lesions of KACM. The diagnostic difficulty and the therapeutic failure of imiquimod, intralesional methotrexate (MTX), and isotretinoin, as well as the therapeutic success of 5-fluorouracil (5-FU) cream, are discussed.
authors.affiliation: Pennsylvania Hospital, Philadelphia, USA.
authors.forename: Allison K
authors.initials: AK
authors.lastname: Divers
authors.forename: Dana
authors.initials: D
authors.lastname: Correale
authors.forename: Jason B
authors.initials: JB
authors.lastname: Lee
mesh_terms: D000368:Aged; D003879:Dermatologic Agents / Q000627:therapeutic use; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015474:Isotretinoin / Q000627:therapeutic use; D007636:Keratoacanthoma / Q000188:drug therapy* / Q000473:pathology*; D007868:Leg Dermatoses / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D017211:Treatment Failure
chemical_list: D003879:Dermatologic Agents; D007166:Immunosuppressive Agents; D015474:Isotretinoin; D005472:Fluorouracil