title: Influence of androgen deprivation therapy on volume of anatomic zones of prostate in patients with prostate cancer using magnetic resonance imaging.
abstract: OBJECTIVE
  To clarify the influence of androgen deprivation therapy (ADT) on the volume of the anatomic zones of the prostate and the tissue component of the transition zone.
  
  
  METHODS
  Thirty patients with prostate cancer arising and localizing in the peripheral zone were enrolled in this study. The volume of anatomic zones was measured using magnetic resonance imaging before and 6 months after ADT (castration and flutamide). Binary images were constructed to analyze the tissue components of the transition zone.
  
  
  RESULTS
  The volumes after ADT in the whole prostate, transition zone, and peripheral zone were significantly smaller than the corresponding volumes before ADT (P <0.001). A small correlation was found between the reduction rates of the transition zone after therapy and the stromal rates of the transition zone (r(s) = 0.375, P = 0.041).
  
  
  CONCLUSIONS
  The present results revealed that, not only the epithelial region in the transition zone, but also the stromal region, was sensitive to androgen and the volume of the transition zone was reduced during ADT regardless of its histologic components.
authors.affiliation: Division of Urology, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishiyama
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Tomita
authors.forename: Kota
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use*; D005485:Flutamide / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000097:blood / Q000473:pathology* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000628:therapy; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D000726:Androgen Antagonists; D005485:Flutamide; D017430:Prostate-Specific Antigen