title: Dendritic cells and autoimmunity.
abstract: Dendritic cells (DC) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Because of their capacity to stimulate naive T cells, DC have a central role in the initiation of primary immune responses and are considered promising tools and targets for immunotherapy. Emerging data suggest a role for DC in initiating autoimmune attacks. Direct analysis of DC phenotypes and DC-T-cell interactions in rodent and human autoimmune diseases should shed light on how pathogenesis occurs, and suggest novel avenues of treatment aimed at alleviating deviant DC function.
authors.affiliation: INSERM U430 and Université Pierre et Marie Curie, Institut des Cordeliers, 15 rue de l'Ecole de Médecine, Paris 75006, France.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
authors.forename: Marina
authors.initials: M
authors.lastname: Thirion
authors.forename: Sandrine
authors.initials: S
authors.lastname: Delignat
authors.forename: Namita
authors.initials: N
authors.lastname: Misra
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lacroix-Desmazes
authors.forename: Michel D
authors.initials: MD
authors.lastname: Kazatchkine
authors.forename: Srini V
authors.initials: SV
authors.lastname: Kaveri
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology* / Q000502:physiology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000503:physiopathology; D002450:Cell Communication / Q000276:immunology* / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology* / Q000502:physiology; D006801:Humans; D051379:Mice; D051381:Rats; D017634:Self Tolerance / Q000276:immunology* / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology