BanI polymorphism of the cytosolic phospholipase A2 gene and mood disorders in the Korean population.
Membrane phospholipid abnormalities have been proposed to be involved in the pathogenesis of mood disorders, and in signal transduction and neurotransmitter uptake. Cytosolic phospholipase A2 (cPLA2) is not only an essential enzyme in the metabolism of fatty acids but also in signaling process. Therefore, we examined the association between the BanI polymorphism of the cPLA2 gene and mood disorders. Sixty-two patients with major depressive disorder (MDD), 50 patients with bipolar I disorder (BID) and 117 healthy controls participated in this study. Genotyping was performed by using PCR-based methods. Genotype and allele distributions in MDD patients were significantly different from those of the controls. In particular, the A2 allele was associated with increased risk of MDD development (p = 0.007, odds ratio = 1.827; confidence interval = 1.141-2.927). However, the polymorphism was not different between BID patients and controls in genotype and allele distribution. This preliminary study indicates the need for further studies on the potential role of the cPLA2 gene polymorphism in the susceptibility to mood disorders.
Pae
Chi-Un
CU
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea.
Yu
Hye-Sook
HS
Kim
Jung-Jin
JJ
Lee
Chang-Uk
CU
Lee
Soo-Jung
SJ
Lee
Kyoung-Uk
KU
Jun
Tae-Youn
TY
Paik
In-Ho
IH
Serretti
Alessandro
A
Lee
Chul
C
D000328:Adult; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000145:classification / Q000235:genetics*; D016017:Odds Ratio; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D012333:RNA, Messenger; D010741:Phospholipases A; D054467:Phospholipases A2