title: Lack of in vitro effect of ivermectin on Plasmodium falciparum.
abstract: The in vitro activity of ivermectin was assessed against the K1 isolate of Plasmodium falciparum. The mean IC50 and IC90 of ivermectin were 8.0 and 35.0 microg/ml, respectively. These results indicate that ivermectin has a very low activity against P. falciparum in vitro.
authors.affiliation: Australian Army Malaria Institute, Gallipoli Barracks, Enoggera, QLD, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Nasveld
authors.forename: Bruce
authors.initials: B
authors.lastname: Russell
authors.forename: Barbara
authors.initials: B
authors.lastname: Kotecka
authors.forename: Karl
authors.initials: K
authors.lastname: Rieckmann
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007559:Ivermectin / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D012044:Regression Analysis
chemical_list: D000981:Antiprotozoal Agents; D007559:Ivermectin