title: Controlled-release oxycodone for the management of pediatric postoperative pain.
abstract: Studies addressing pain management after pediatric spinal fusion surgery have focused on the use of patient-controlled or epidural analgesia during the immediate postoperative period. Controlled-release (CR) analgesics have been found to be safe and effective in adults. The purpose of this study was to describe the use of oxycodone-CR in pediatric patients after the immediate postoperative period. A retrospective chart review of 62 postoperative spinal fusion patients (10-19 years) was conducted. The mean initial oxycodone-CR dose was 1.24 mg/kg/day. The mean ratio of conversion from parenteral morphine equivalents to oxycodone-CR was 1:1. Mean pain scores decreased from 4.2/10 to 3.7/10 with the transition to oxycodone-CR. Common side effects included dizziness, constipation, and nausea. Oxycodone-CR was used for an average of 13.3 days, which included an average wean time of 6 days. Results of this study demonstrate safe and effective use of oxycodone-CR in the pediatric spinal fusion population.
authors.affiliation: Jane B. Pettit Pain and Palliative Care Center, Chidren's Hospital of Wisconsin, Milwaukee, 53201, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Czarnecki
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Jandrisevits
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Theiler
authors.forename: Myra Martz
authors.initials: MM
authors.lastname: Huth
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Weisman
mesh_terms: D000293:Adolescent; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D002648:Child; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008297:Male; D010098:Oxycodone / Q000008:administration & dosage* / Q000009:adverse effects; D010149:Postoperative Pain / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D010098:Oxycodone