title: Preparation of polyhydroxyalkyl- and C-glycosylfuran derivatives from free sugars catalyzed by cerium(III) chloride in aqueous solution: an improvement of the Garcia González reaction.
abstract: Unprotected aldose sugars react smoothly with 1,3-diones or beta-ketoesters in the presence of CeCl(3).7H(2)O in aqueous solution to produce polyhydroxylalkyl- and C-glycosylfuran derivatives in excellent yield. Operationally simple, mild neutral reaction conditions in aqueous solution is the key feature of this methodology.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. akmisra69@rediffmail.com
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
authors.forename: Geetanjali
authors.initials: G
authors.lastname: Agnihotri
mesh_terms: D002241:Carbohydrates / Q000737:chemistry; D002563:Cerium / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D015394:Molecular Structure; D012996:Solutions
chemical_list: D002241:Carbohydrates; D005663:Furans; D006027:Glycosides; D012996:Solutions; D002563:Cerium; C026690:cerous chloride