title: Applications of eTag trade mark assay platform to systems biology approaches in molecular oncology and toxicology studies.
abstract: We have developed a universal eTag trade mark multiplex assay platform that can be uniquely applied to survey the molecule profiles of biologic systems in sub-global large-scale analyses. The effectiveness of eTag trade mark assays when applied to focused system biology studies in molecular oncology and predictive toxicology is herein described while reviewing the current methods commonly used. The multi-analyte and multi-parameter assay approach for parallel analysis will form the basis of an emerging paradigm of multiplexed molecular profiling for signaling pathway networks and various aspects of drug development processes.
authors.affiliation: Aclara BioSciences, Inc., Mountain View, CA 94043, USA.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Chan-Hui
authors.forename: K
authors.initials: K
authors.lastname: Stephens
authors.forename: R A
authors.initials: RA
authors.lastname: Warnock
authors.forename: S
authors.initials: S
authors.lastname: Singh
mesh_terms: D020869:Gene Expression Profiling / Q000295:instrumentation / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D008495:Medical Oncology / Q000295:instrumentation / Q000379:methods*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods*; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology; D014116:Toxicology / Q000295:instrumentation / Q000379:methods*