Neuronal globus pallidus activity in patients with generalised dystonia.
We studied 516 globus pallidus neurons in dystonic patients. The firing rate was analysed. We classified the burst activity into tonic, burst, and pause patterns. Mean +/- SD firing rates and tonicity score for internal globus pallidus (GPi) and external globus pallidus (GPe) were 54.6 +/- 28.6; 58.01 +/- 39.1 and 1.18 +/- 0.55; 0.95 +/- 0.43, respectively. Differences in percentage appearance of tonic, burst, or paused neurons were not statistically significant for GPi versus GPe. GPi firing features in dystonic patients were closely similar to those of GPe. This could suggest that the abnormally patterned output from GPi would not result from increased differential inhibitory/excitatory input arising from the direct/indirect pathway but rather be transmitted from GPe, striatum, or either centromedian nucleus.
Merello
Marcelo
M
Movement Disorders Section, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina. mmerello@fleni.org.ar
Cerquetti
Daniel
D
Cammarota
Angel
A
Tenca
Eduardo
E
Artes
Carlos
C
Antico
Julio
J
Leiguarda
Ramon
R
D000293:Adolescent; D002648:Child; D004185:Disability Evaluation; D004421:Dystonia / Q000235:genetics / Q000503:physiopathology* / Q000601:surgery; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000295:instrumentation; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D018832:Molecular Chaperones / Q000235:genetics; D009474:Neurons / Q000473:pathology; D012720:Severity of Illness Index
D018832:Molecular Chaperones; C108175:TOR1A protein, human