title: Suppression of Hodgkin's disease in a patient with Cushing's syndrome.
abstract: Hodgkin's disease, one of the more common tumors in pediatric oncology, has been shown to be highly responsive to steroids in conjunction with other chemotherapy agents. The authors describe a patient with Cushing's syndrome that suppressed his Hodgkin's disease. He developed constitutional symptoms, and his Hodgkin's disease progressed after the removal of his pituitary tumor. The patient is disease-free following ABVD/MOPP chemotherapy. A high level of steroids before treatment, albeit endogenous, did not preclude successful treatment of Hodgkin's disease. The effect of Cushing's syndrome on Hodgkin's disease has not been previously reported.
authors.affiliation: Division of Hematology Oncology, Department of Pediatrics, Emory University and AFLAC Cancer Center and Blood Disorders Services of Children's Healthcare of Atlanta, Atlanta, Georgia, USA. Della.Howell@choa.org
authors.forename: Della L
authors.initials: DL
authors.lastname: Howell
authors.forename: John
authors.initials: J
authors.lastname: Bergsagel
authors.forename: Roland
authors.initials: R
authors.lastname: Chu
authors.forename: Lillian
authors.initials: L
authors.lastname: Meacham
mesh_terms: D000305:Adrenal Cortex Hormones / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000097:blood; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002648:Child; D003480:Cushing Syndrome / Q000150:complications* / Q000209:etiology; D018450:Disease Progression; D006689:Hodgkin Disease / Q000150:complications* / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000601:surgery
chemical_list: D000305:Adrenal Cortex Hormones; D018931:Antineoplastic Agents, Hormonal; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone