title: Efficacy of platelet-rich plasma in alveolar bone grafting.
abstract: OBJECTIVE
  In this study, we performed alveolar bone grafting with autologous iliac cancellous bone incorporation with platelet-rich plasma (PRP) and evaluated its efficacy in osteoregeneration.
  
  
  METHODS
  Seven alveolar cleft patients with adult dentition (average age, 16.1 years) underwent iliac bone grafting with PRP. Quantitative evaluation of regenerated bone was made with 3-dimensional computed tomography scans and compared with controls.
  
  
  RESULTS
  The average of the volume ratio of regenerated bone to alveolar cleft in cases with PRP was higher than in controls (P <.05). There were no complications from the blood draw or PRP.
  
  
  CONCLUSIONS
  PRP was a safe and cost-effective source for growth factors and was easy to extract. It could enhance the osteogenesis of alveolar bone grafting in cleft lip and palate patients and may useful for subsequent orthodontic therapy.
authors.affiliation: Department of Plastic Surgery, Kobe Children's Hospital, Japan. Tomoki.Oyama@mb2.seikyou.ne.jp
authors.forename: Tomoki
authors.initials: T
authors.lastname: Oyama
authors.forename: Soh
authors.initials: S
authors.lastname: Nishimoto
authors.forename: Tomoe
authors.initials: T
authors.lastname: Tsugawa
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Shimizu
mesh_terms: D000293:Adolescent; D000539:Alveolar Process / Q000002:abnormalities; D000543:Alveoloplasty / Q000379:methods*; D001792:Blood Platelets / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods*; D002971:Cleft Lip / Q000150:complications; D002972:Cleft Palate / Q000601:surgery; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D017713:Platelet Transfusion; D014014:Tissue Adhesives / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives