The biology of dendritic cells and their potential use in veterinary medicine.
Dendritic cells have been shown to be the main antigen-presenting cells in vitro and in vivo, playing a pivotal role in the induction of both tolerance and immunity. Dendritic cells from humans and mice have been extensively studied and dendritic cell-based vaccines have been shown to be effective in the prevention and treatment of infectious, allergic and neoplastic diseases. Studies of dendritic cells of domestic animal origin are becoming available and confirm a role for these cells in the pathogenesis of a variety of animal diseases, suggesting that dendritic cells could be used as adjuvants for prophylactic and therapeutic strategies in veterinary medicine.
Vanloubbeeck
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Y
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.
Hostetter
J
J
Jones
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DE
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000818:Animals; D019496:Cancer Vaccines / Q000627:therapeutic use; D003713:Dendritic Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000662:veterinary*; D014612:Vaccines / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D019496:Cancer Vaccines; D014612:Vaccines