In vitro skin penetration of dazmegrel delivered with a bioelastic matrix.
The penetration of dazmegrel, a selective thromboxane synthetase inhibitor, through excised human and greyhound skin was measured. A bioelastic matrix was used for topical delivery. Results demonstrated that dazmegrel readily penetrated the skin. Penetration through greyhound skin was significantly greater than penetration through human skin. Penetration through greyhound skin was not significantly different between 4, 24, and 48 h of exposure for the low and intermediate doses studied.
Kemppainen
Barbara W
BW
Department of Anatomy, Physiology, & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. kemppbw@auburn.edu
Urry
Dan W
DW
Luan
Chi-Xiang
CX
Xu
Jie
J
Swaim
Steven F
SF
Goel
Saryu
S
D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics*; D006801:Humans; D007093:Imidazoles / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D010539:Permeability; D012869:Skin Absorption
D004791:Enzyme Inhibitors; D007093:Imidazoles; C039242:dazmegrel