Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency.
A 58-year-old woman was admitted at diagnosis of type 2 diabetes without keto-acidosis. Blood glucose was normalized initially with insulin. Whilst taking glibenclamide, she developed acute haemolysis. She was homozygous for glucose-6-phosphate dehydrogenase (G6PD) deficiency and had no other factors predisposing haemolysis. We reviewed the literature and discuss the relationship between glibenclamide and haemolytic crisis and between G6PD-deficiency and diabetes.
Vinzio
Stéphane
S
Service de Médecine Interne et de Nutrition, Hôpital de Hautepierre, 67098 Strasbourg Cedex, France. stephane.vinzio@chru-strasbourg.fr
Andrès
Emmanuel
E
Perrin
Anne-Elisabeth
AE
Schlienger
Jean-Louis
JL
Goichot
Bernard
B
D000743:Anemia, Hemolytic / Q000139:chemically induced* / Q000150:complications; D044383:Black People / Q000208:ethnology / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D005602:France; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D005905:Glyburide / Q000009:adverse effects* / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000737:chemistry; D006720:Homozygote; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D013997:Time Factors
D001786:Blood Glucose; D005905:Glyburide; D006442:Glycated Hemoglobin; D007328:Insulin; D008687:Metformin