title: A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France.
abstract: We report a cluster of pediatric diarrhea due to Shigella dysenteriae serotype 1 involving 11 children in France, including the index case, who had returned from Senegal. Child-to-child transmission was documented by ribotyping. Five children developed hemolytic uremic syndrome (HUS). On the basis of our findings, the choice of antimicrobial treatment for infections with S. dysenteriae serotype 1 should take into account widespread drug resistance and the risk of HUS.
authors.affiliation: Services de Microbiologie, Hôpital Robert Debré, Paris, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Houdouin
authors.forename: Catherine
authors.initials: C
authors.lastname: Doit
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.forename: Naïma
authors.initials: N
authors.lastname: Brahimi
authors.forename: Chantal
authors.initials: C
authors.lastname: Loirat
authors.forename: Antoine
authors.initials: A
authors.lastname: Bourrillon
authors.forename: Edouard
authors.initials: E
authors.lastname: Bingen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000150:complications; D024881:Drug Resistance, Bacterial; D004405:Dysentery, Bacillary / Q000150:complications*; D005260:Female; D005602:France; D006463:Hemolytic-Uremic Syndrome / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D012762:Shigella dysenteriae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents