title: Invasive pneumococcal infection in a healthy infant caused by two different serotypes.
abstract: We present a case of invasive pneumococcal infection in a healthy 10-month-old infant from whom Streptococcus pneumoniae serotype 23F was isolated from the blood and serotype 23B was isolated from the cerebrospinal fluid. Both serotypes were penicillin nonsusceptible. Pulsed-field gel electrophoresis analysis demonstrated that the two serotypes had distinct DNA patterns, indicating that infection did not occur as a result of capsular transformation but as a result of a mixed infection with two distinct pneumococcal serotypes.
authors.affiliation: Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goyania, Brazil. ana@iptsp.ufg.br
authors.forename: Ana Lucia S Sgambatti
authors.initials: AL
authors.lastname: de Andrade
authors.forename: Fabiana Cristina
authors.initials: FC
authors.lastname: Pimenta
authors.forename: Cristina Aparecida Borges
authors.initials: CA
authors.lastname: Laval
authors.forename: João Guimarães
authors.initials: JG
authors.lastname: de Andrade
authors.forename: Maria Luiza
authors.initials: ML
authors.lastname: Guerra
authors.forename: Maria Cristina C
authors.initials: MC
authors.lastname: Brandileone
mesh_terms: D016470:Bacteremia / Q000382:microbiology; D001769:Blood / Q000382:microbiology; D001938:Brazil; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D007223:Infant; D008297:Male; D008586:Meningitis, Pneumococcal / Q000382:microbiology; D011008:Pneumococcal Infections / Q000382:microbiology*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification
chemical_list: D004269:DNA, Bacterial