title: [A case of advanced gastric cancer successfully treated with neoadjuvant chemotherapy of combined weekly paclitaxel and doxifluridine (5'-DFUR)].
abstract: We report a case of advanced gastric cancer with metastasis to the paraaortic lymph nodes that showed a remarkable response to treatment with a combination of weekly paclitaxel and doxifluridine (5'-DFUR). The patient was a 72-year-old man. Oral chemotherapy of TS-1 was discontinued due to drug induced eruption. Alternatively, we administered weekly paclitaxel/5'-DFUR combination therapy. Paclitaxel was infused at a dose of 100-130 mg after short premedication and continued for 2-3 weeks with a 1 week rest. 5'-DFUR was administered orally at a dose of 800 mg/day for 14-21 consecutive days. After 4 courses of this therapy, the primary carcinoma and lymph nodes decreased in size (PR). Consequently, the patient underwent a total gastrectomy with paraaortic lymph node dissection, which resulted in a curative resection of the cancer cells macroscopically. Except for afebrile neutropenia (grade 4), no major adverse reactions were observed. Histological examination revealed that the cancer cells were degenerated to a moderate extent. Weekly paclitaxel/5'-DFUR combination may be a promising regimen for patients with advanced gastric cancer as preoperative chemotherapy.
authors.affiliation: Dept. of Surgery, Shimane Prefectural Central Hospital.
authors.forename: Hajime
authors.initials: H
authors.lastname: Hikino
authors.forename: Takako
authors.initials: T
authors.lastname: Yamada
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tokuka
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ozaki
authors.forename: Saburo
authors.initials: S
authors.lastname: Nagaoka
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D004334:Drug Administration Schedule; D005467:Floxuridine / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D005467:Floxuridine; D017239:Paclitaxel; C025034:doxifluridine