Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors.
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Lim
Hyun-Suk
HS
Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja-Dong, Nam-gu, Pohang 790-784, South Korea.
Park
Jeong-Ju
JJ
Ko
Kwangseok
K
Lee
Mee-Hyun
MH
Chung
Sung-Kee
SK
D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D006801:Humans; D008024:Ligands; D008246:Lysophospholipids / Q000737:chemistry*; D008958:Models, Molecular; D011485:Protein Binding; D011869:Radioligand Assay; D049349:Receptors, Lysosphingolipid / Q000737:chemistry*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D040681:Structural Homology, Protein; D013329:Structure-Activity Relationship; D014162:Transfection
D008024:Ligands; D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine