title: Incidence of a clinical diagnosis of the irritable bowel syndrome in a United States population.
abstract: BACKGROUND
  The incidence of irritable bowel syndrome is uncertain. We aimed to determine the incidence of clinically diagnosed irritable bowel syndrome in the community.
  
  
  METHODS
  Using the Rochester Epidemiology Project, all diagnoses of irritable bowel syndrome made among adult residents of Olmsted County, Minnesota, over a 3-year period were identified. The complete medical records of a random sample of the potential subjects were reviewed for the 10 years prior to the irritable bowel syndrome diagnosis and any patient who had received a previous diagnosis of irritable bowel syndrome was excluded (prevalent cases).
  
  
  RESULTS
  The diagnostic index listed 1245 possible irritable bowel syndrome patients; 416 patient charts were reviewed and, of these, 149 were physician diagnosed incident cases of irritable bowel syndrome. The age- and sex-adjusted incidence rate was 196 per 100,000 person-years and increased with age (P = 0.006). The age-adjusted annual incidence per 100,000 in women was higher than in men: 238 vs. 141 (ratio 3:2; P = 0.005). The overall symptom frequency at the time of diagnosis was abdominal pain (73%), diarrhoea (41%) and constipation (16%).
  
  
  CONCLUSIONS
  The incidence of a clinical diagnosis of irritable bowel syndrome in adults was estimated to be two per 1000 per year, increased with age and was higher in women than men. As many people with irritable bowel syndrome do not seek care, the true incidence of irritable bowel syndrome is likely to be higher.
authors.affiliation: Mayo Clinic College of Medicine, Rochester, MN 55905, USA. locke.giles@mayo.edu
authors.forename: G R
authors.initials: GR
authors.lastname: Locke
authors.forename: B P
authors.initials: BP
authors.lastname: Yawn
authors.forename: P C
authors.initials: PC
authors.lastname: Wollan
authors.forename: L J
authors.initials: LJ
authors.lastname: Melton
authors.forename: E
authors.initials: E
authors.lastname: Lydick
authors.forename: N J
authors.initials: NJ
authors.lastname: Talley
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D043183:Irritable Bowel Syndrome / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D012044:Regression Analysis; D017678:Sex Distribution