title: Toward a molecular genetic classification of familial hemiplegic migraine.
abstract: The genetics of migraine is a fascinating and rapidly moving research area. Familial hemiplegic migraine, a rare subtype of migraine with a Mendelian pattern of inheritance, is caused by mutations in the chromosome 19 CACNA1A gene or in the chromosome 1 ATP1A2 gene. Familial migraine variants are classified on the basis of clinical, descriptive criteria, but this is insufficient. In the future, a diagnostic classification based on mutation-analysis is needed.
authors.affiliation: Department of Neurology (K5Q), Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.
authors.forename: Joost
authors.initials: J
authors.lastname: Haan
authors.forename: Esther E
authors.initials: EE
authors.lastname: Kors
authors.forename: Arn M J M
authors.initials: AM
authors.lastname: van den Maagdenberg
authors.forename: Kaate R J
authors.initials: KR
authors.lastname: Vanmolkot
authors.forename: Gisela M
authors.initials: GM
authors.lastname: Terwindt
authors.forename: Rune R
authors.initials: RR
authors.lastname: Frants
authors.forename: Michel D
authors.initials: MD
authors.lastname: Ferrari
mesh_terms: D006801:Humans; D020325:Migraine with Aura / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics
chemical_list: C498531:ATP1A2 protein, human; D000254:Sodium-Potassium-Exchanging ATPase