Discrete intracellular signaling domains of soluble adenylyl cyclase: camps of cAMP?
Soluble adenylyl cyclase can function in the nucleus, defining a nuclear microdomain of adenosine 3',5'-monophosphate (cAMP) signaling. Bundey and Insel discuss the evidence for discrete signaling microdomains of cAMP, including the nucleus and caveolae, and conclude that such microdomains may be defined by the localized, subcellular expression of adenylyl cyclase isoforms.
Bundey
Richard A
RA
Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92037-0636, USA. rbundey@ucsd.edu
Insel
Paul A
PA
D000262:Adenylyl Cyclases / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D021941:Caveolae / Q000201:enzymology; D002467:Cell Nucleus / Q000201:enzymology; D000242:Cyclic AMP / Q000378:metabolism*; D008954:Models, Biological; D020033:Protein Isoforms / Q000378:metabolism; D015290:Second Messenger Systems
D020033:Protein Isoforms; D000242:Cyclic AMP; D000262:Adenylyl Cyclases