The role of Tec family kinases in myeloid cells.
Members of the Tec kinase family (Bmx, Btk, Itk, Rlk and Tec) are primarily expressed in the hematopoietic system and form, after the Src kinase family, the second largest class of non-receptor protein tyrosine kinases. During lymphocyte development and activation Tec kinases have important functions in signaling pathways downstream of the antigen receptors. Tec family kinases are also expressed in cells of the myeloid lineage. However, with the exception of mast cells and platelets, their biological role in the myeloid system is only poorly understood. This review summarizes the current knowledge about the function of Tec family kinases in hematopoietic cells of the myeloid lineage.
Schmidt
Uwe
U
Medical University of Vienna, Institute of Immunology, Vienna, Austria.
Boucheron
Nicole
N
Unger
Bernd
B
Ellmeier
Wilfried
W
D001792:Blood Platelets / Q000201:enzymology; D003713:Dendritic Cells / Q000201:enzymology; D004789:Enzyme Activation / Q000502:physiology; D041905:Erythroid Cells / Q000201:enzymology; D006801:Humans; D008407:Mast Cells / Q000201:enzymology; D022423:Myeloid Cells / Q000201:enzymology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases