title: Topiramate efficacy in an infant with partial seizures refractory to conventional antiepileptic drugs.
abstract: Many studies showed that Topiramate (TPM) may be a useful drug in a wide spectrum of childhood epilepsies. We report a 3-month-old female with stormy onset of secondarily generalized partial seizures. She showed a high seizure frequency and a progressive worsening electroencephalogram (EEG), despite standard antiepileptic drugs administration. TPM succeeded in controlling seizures, even after the other drugs were discontinued. This case suggests that TPM may represent a good choice for the treatment of partial seizures refractory to conventional drugs in infants.
authors.affiliation: Child Neuropsychiatry Department, Neurological Institute Casimiro Mondino Foundation IRCCS, University of Pavia, Pavia, Italy. pveggiot@unipv.it
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Veggiotti
authors.forename: Francesca
authors.initials: F
authors.lastname: Longaretti
authors.forename: Sabrina
authors.initials: S
authors.lastname: Signorini
authors.forename: Simonetta
authors.initials: S
authors.lastname: Cardinali
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lanzi
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004351:Drug Resistance; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D000077236:Topiramate
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose