title: New start and finish for complex polyketide biosynthesis.
abstract: The polyketide vicenistatin has significant anticancer activity. In the January issue of Chemistry & Biology, Kakinuma and coworkers reported on the vicenistatin biosynthetic gene cluster and demonstrated in vitro glycosylation of its aglycone core, raising the possibility of producing analogs with altered sugar residues.
authors.affiliation: Department of Industrial Microbiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Caffrey
mesh_terms: D000617:Aminoglycosides / Q000096:biosynthesis* / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D007769:Lactams / Q000138:chemical synthesis / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000617:Aminoglycosides; D000970:Antineoplastic Agents; D007769:Lactams; D018942:Macrolides; C082785:vicenistatin