Characterization of a novel human gene containing ANK repeats and ARM domains.
We report here on characterization of a novel human gene on chromosome 2q32, containing several ankyrin repeats and ARM domains. The gene FLJ25415, including at least 31 exons and spanning about 90kb of a gene-rich genomic region, is present in the human genome as a single copy. It seems highly conserved along the mammalian phylogeny. By analysing FLJ25415 gene expression in different human tissues, we demonstrated a ubiquitously expression pattern with extensive alternative splicing. In silico prediction of promoter regions revealed the presence of a TATA box and some hypothetical transcription factor binding sites, such as TMF, C/EBPalpha, LE-1, and NF-ATp.
Occhi
Gianluca
G
Department of Biology, University of Padua, Padua, Italy.
Olivieri
Massimiliano
M
Rampazzo
Alessandra
A
Danieli
Gian Antonio
GA
D017398:Alternative Splicing; D000818:Animals; D017089:Ankyrin Repeat / Q000235:genetics*; D001483:Base Sequence; D001665:Binding Sites; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons / Q000235:genetics; D020224:Expressed Sequence Tags; D015870:Gene Expression; D005796:Genes / Q000235:genetics; D006801:Humans; D007438:Introns / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000235:genetics*; D026723:Polyadenylation; D011401:Promoter Regions, Genetic / Q000235:genetics; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment; D016385:TATA Box / Q000235:genetics; D024363:Transcription Initiation Site
D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger