[Evolution and virulence of primate lentiviruses].
While the AIDS epidemic caused by human immunodeficiency viruses (HIV) has resulted in the death of over 20 million people worldwide, simian immunodeficiency virus (SIV) infection, found in numerous African primate species, does not induce disease symptoms. The factors accounting for this difference between humans and natural host of SIV remain poorly understood. The entangled nature of the host/virus relationship could be the answer, rather than independent virus or host factors. Such a relationship is as a consequence of host/virus adaptation which has evolved over long periods in naturally infected primate species.
Courgnaud
Valérie
V
Laboratoire des rétrovirus UR 36, 911, avenue Agropolis, BP 64501, 34034 Montpellier Cedex 5, France.
Müller-Trutwin
Michaela
M
Sonigo
Pierre
P
D000222:Adaptation, Physiological; D000818:Animals; D019143:Evolution, Molecular; D005814:Genes, Viral; D016086:Lentivirus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D016180:Lentivirus Infections / Q000662:veterinary / Q000821:virology; D010802:Phylogeny; D018419:Primate Diseases / Q000821:virology; D011323:Primates / Q000821:virology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000502:physiology; D013045:Species Specificity; D016176:T-Lymphocyte Subsets / Q000821:virology; D019562:Viral Load; D014774:Virulence / Q000235:genetics; D014779:Virus Replication