The effects of calcitonin on acute bone loss after pertrochanteric fractures. A prospective, randomised trial.
We investigated the effect of calcitonin in the prevention of acute bone loss after a pertrochanteric fracture and its ability to reduce the incidence of further fractures in the same patient. Fifty women aged between 70 and 80 years who had a pertrochanteric fracture of the hip were randomly allocated to group A (200 IU of nasal salmon calcitonin daily for three months) or group B (placebo). Patients in group A showed a significantly higher level of total alkaline phosphatase and osteocalcin on the 15th day after injury and a significantly higher level of bone alkaline phosphatase on the 90th day after surgery. These patients also had significantly lower levels of urinary C-telopeptide (CrossLaps) on the 15th, 45th and 90th days after injury and lower levels of urinary hydroxyproline on the 15th and 45th days after injury. Patients in group A had significantly higher bone mineral density at all recorded sites except the greater trochanter at three months and one year after operation. After a four-year period of clinical observation, five patients (24%) in group B sustained a new fracture, in four of whom (20%) it was of the contralateral hip. Our findings show that calcitonin reduces acute bone loss in patients with pertrochanteric fractures and may prevent the occurrence of new fractures of the contralateral hip in the elderly.
Karachalios
T
T
Laboratory for the Research of the Musculoskeletal System, Athens, Greece.
Lyritis
G P
GP
Kaloudis
J
J
Roidis
N
N
Katsiri
M
M
D000208:Acute Disease; D000281:Administration, Intranasal; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density / Q000502:physiology; D002116:Calcitonin / Q000008:administration & dosage*; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D005260:Female; D006620:Hip Fractures / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D015675:Osteocalcin / Q000097:blood; D010014:Osteolysis / Q000188:drug therapy* / Q000378:metabolism; D010455:Peptides / Q000652:urine; D011446:Prospective Studies; D012008:Recurrence
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D002116:Calcitonin; D003094:Collagen; D000469:Alkaline Phosphatase; D006909:Hydroxyproline