Study of genetic expression of intrauterine growth factors IGF-I and EGFR in placental tissue from pregnancies with intrauterine growth retardation.
To investigate the possibility of altered gene expression of growth factors in prenatal growth retardation, we assessed expression of the genes for insulin-like growth factor-I (IGF-I) and epidermal growth factor receptor (EGFR) by RT-PCR from human placentas at term delivery in two groups: appropriate for gestational age (AGA) and pregnancies complicated with IUGR. The placentas from IUGR gestations showed reduced IGF-I expression with a significance of p = 0.008, whereas we did not find any significant differences in EGFR gene expression.
Calvo
M T
MT
Department of Molecular Genetics, University Children's Hospital Miguel Servet, University of Zaragoza, Spain. mtcalvo@salud.aragob.es
Romo
A
A
Gutiérrez
J J
JJ
Relaño
E
E
Barrio
E
E
Ferrández Longás
A
A
D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D015870:Gene Expression; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D010920:Placenta / Q000166:cytology* / Q000502:physiology / Q000503:physiopathology; D011247:Pregnancy; D012337:RNA, Ribosomal, 18S / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D012337:RNA, Ribosomal, 18S; D007334:Insulin-Like Growth Factor I; D066246:ErbB Receptors