title: Effects of, and corrections for, cross-term interactions in Q-space MRI.
abstract: The present study assesses the effects of cross-term interactions between diffusion and imaging gradients in magnetic resonance imaging q-space analysis, and corrects for those effects for both spin echo and stimulated echo diffusion-weighted sequences. These corrections are demonstrated experimentally in unrestricted media for water and theoretically by simulating the case of restricted diffusion in a sphere. By correcting for the cross-term interactions, large imaging gradients can be used without compromising the results. Ignoring cross-term interactions could lead to a misunderstanding of the q-space analysis; for instance, the microstructural size of the sample could be overestimated, or isotropic media could be misinterpreted as being anisotropic.
authors.affiliation: Herchel Smith Laboratory for Medicinal Chemistry, University of Cambridge School of Clinical Medicine, University Forvie Site, Cambridge, UK.
authors.forename: Oscar
authors.initials: O
authors.lastname: Brihuega-Moreno
authors.forename: Frank P
authors.initials: FP
authors.lastname: Heese
authors.forename: Cristián
authors.initials: C
authors.lastname: Tejos
authors.forename: Laurance D
authors.initials: LD
authors.lastname: Hall
mesh_terms: D038524:Diffusion Magnetic Resonance Imaging; D008962:Models, Theoretical; D019047:Phantoms, Imaging