Heterologous mevalonate production in Streptomyces lividans TK23.
Mevalonate is a ubiquitous biosynthetic intermediate of terpenoids and is used as a moisturizer in cosmetics and a chemical for biochemical research. In this study, we have achieved a heterologous production of this useful compound by expression in Streptomyces lividans TK23 of 3-hydroxy-3-methylglutaryl-CoA synthase and 3-hydroxy-3-methylglutaryl-CoA reductase genes, which were cloned from Streptomyces sp. strain CL190.
Kuzuyama
Tomohisa
T
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan. utkuz@mail.ecc.u-tokyo.ac.jp
Dairi
Tohru
T
Yamashita
Haruyuki
H
Shoji
Yoshikazu
Y
Seto
Haruo
H
D004896:Erythritol / Q000031:analogs & derivatives* / Q000378:metabolism; D005822:Genetic Vectors / Q000235:genetics; D008798:Mevalonic Acid / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D048170:Streptomyces lividans / Q000235:genetics / Q000378:metabolism*; D013403:Sugar Phosphates / Q000378:metabolism; D014169:Transformation, Bacterial
C114232:2-C-methylerythritol 4-phosphate; D013403:Sugar Phosphates; D004896:Erythritol; D008798:Mevalonic Acid