title: Finding Cinderella after the ball: a three-hybrid approach to drug target identification.
abstract: A major bottleneck in drug discovery is identifying the targets of small molecules. The yeast three-hybrid assay extends the two-hybrid approach to screen for protein-small molecule interactions. In this issue of Chemistry & Biology, GPC Biotech reports the first application of this promising assay.
authors.affiliation: Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Lefurgy
authors.forename: Virginia
authors.initials: V
authors.lastname: Cornish
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D015723:Gene Library; D020798:Two-Hybrid System Techniques