title: Spindle cell carcinoma of the larynx.
abstract: Four rare cases of spindle cell carcinoma of the larynx are reported and the histo-pathological and immuno-histochemical findings are described. The spindle cell carcinoma involved the right vocal cord of an 88-year-old and an 86-year-old male patients and the anterior commissure of a 76-year-old and a 68-year-old male patients. Two patients underwent total laryngectomy, one patient extirpation under laryngomicrosurgery and one radiation therapy. All were well controlled thereafter and there was no recurrence. Surgery seemed to be the most satisfactory therapeutic approach and radiation therapy was effective in a patient with relatively small tumor. The histo-pathological and immuno-histochemical analysis in one patient revealed a sarcoma-like component of the carcinoma and the findings suggested that this was the result of a metaplastic change in the mesenchyme without inflammatory changes.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, 800 Shijo-cho, Kashihara 637-8522, Nara, Japan. hiroshim@js2.so-net.ne.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyahara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tsuruta
authors.forename: Katsunari
authors.initials: K
authors.lastname: Yane
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008866:Microsurgery; D011881:Radiotherapy, Computer-Assisted; D016896:Treatment Outcome; D014827:Vocal Cords / Q000473:pathology