Treatment of Wilms tumor-related hypertension with losartan and captopril.
Hypertension is commonly associated with Wilms tumor, but hypertension secondary to renin-secreting Wilms tumor is uncommon. We present an infant with severe hypertension and renin hypersecretion, which was resistant to multiple antihypertensive agents. Blood pressure was eventually controlled with a combination of captopril and losartan.
Wong
William
W
Department of Nephrology, Starship Children's Hospital, Grafton, Private Bag 92029, Auckland, New Zealand. wwong@adhb.govt.nz
Mauger
David
D
D047228:Angiotensin II Type 1 Receptor Blockers / Q000627:therapeutic use*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology*; D007223:Infant; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D012083:Renin / Q000378:metabolism; D009396:Wilms Tumor / Q000150:complications* / Q000378:metabolism
D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D012083:Renin; D019808:Losartan