title: Single versus bilateral internal thoracic artery grafts with concomitant saphenous vein grafts for multivessel coronary artery bypass grafting: effects on mortality and event-free survival.
abstract: BACKGROUND
  The issue of superiority of single internal thoracic artery grafting versus bilateral internal thoracic artery grafting remains unresolved. The aim of this study was to compare the long-term outcome of single and bilateral internal thoracic artery grafting with concomitant saphenous vein grafting for multivessel coronary artery bypass grafting.
  
  
  METHODS
  Between March 1985 and April 1995, 6650 patients underwent primary isolated coronary artery bypass grafting with internal thoracic artery grafts, including 4382 patients with multivessel bypass grafting requiring at least 3 grafts. Outcomes of patients undergoing single internal thoracic artery plus saphenous vein grafting (n = 2547) and bilateral internal thoracic artery plus saphenous vein grafting (n = 1835) were obtained at a mean follow-up of 11 +/- 3 years.
  
  
  RESULTS
  Patients with bilateral internal thoracic artery grafting were younger, were mostly male, and had less diabetes, hypertension, unstable angina, and recent myocardial infarction than patients undergoing single internal thoracic artery grafting. Thirty-day mortality was 2.3% for the group undergoing single internal thoracic artery grafting versus 1.2% for those undergoing bilateral internal thoracic artery grafting (P =.007). Survival probability at 10 years was 88% for the single-graft group compared with 93% for the bilateral-graft group (P <.001). Multivariate analysis with propensity scoring showed that bilateral internal thoracic artery grafting decreased the risk of death (hazard ratio, 0.74; 95% confidence interval, 0.60-0.90), myocardial infarction (hazard ratio, 0.79; 95% confidence interval, 0.67-0.93), and coronary reoperation (hazard ratio, 0.41; 95% confidence interval, 0.21-0.80) throughout the follow-up period. Other significant predictors of death were diabetes, prior myocardial infarction, need for intra-aortic balloon pump, chronic heart failure, and peripheral vascular disease.
  
  
  CONCLUSIONS
  Patients undergoing bilateral internal thoracic plus saphenous vein grafting appear to have a significantly better long-term clinical outcome than patients undergoing single internal thoracic artery plus saphenous vein grafting for multivessel coronary artery bypass grafting.
authors.affiliation: Department of Surgery, Montreal Heart Institute, Montreal, Quebec, Canada.
authors.forename: L M
authors.initials: LM
authors.lastname: Stevens
authors.forename: M
authors.initials: M
authors.lastname: Carrier
authors.forename: L P
authors.initials: LP
authors.lastname: Perrault
authors.forename: Y
authors.initials: Y
authors.lastname: Hébert
authors.forename: R
authors.initials: R
authors.lastname: Cartier
authors.forename: D
authors.initials: D
authors.lastname: Bouchard
authors.forename: A
authors.initials: A
authors.lastname: Fortier
authors.forename: I
authors.initials: I
authors.lastname: El-Hamamsy
authors.forename: M
authors.initials: M
authors.lastname: Pellerin
mesh_terms: D001026:Coronary Artery Bypass / Q000401:mortality; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000637:transplantation*; D008875:Middle Aged; D015999:Multivariate Analysis; D011183:Postoperative Complications; D012086:Reoperation; D012501:Saphenous Vein / Q000637:transplantation*; D015996:Survival Rate; D016896:Treatment Outcome