title: Osteosarcoma in children: long-term functional analysis.
abstract: Multimodal, limb-saving therapy is the treatment of choice in children with osteosarcoma. However, few data are available on long-term functional problems and disabilities in surviving patients. Seventy-eight children treated for Stage II-B osteosarcoma who were treated between 1970 and 1997 were evaluated. Beyond the clinical examination, functional results were assessed using the scoring system of the Musculoskeletal Tumor Society. Patients reported their physical disabilities when completing the Toronto Extremity Salvage Score. The most recent cohort of patients who had tumor resection combined with preoperative and postoperative chemotherapy had the best 10-year survival rate at 70%. Thirty-four children (44%) were treated by limb-sparing therapy with 25 children requiring an endoprosthesis. Ten of these 25 children (40%) required one or in some cases several replacements of the endoprostheses because of complications. The original prostheses were in place for a median of 4.9 years before the first exchange (range, 2.0-12.0 years). Evaluations with rating scales showed that the subjective estimation of disabilities by the Toronto Extremity Salvage Score was significantly higher than a rating of limb functions by a doctor using the Musculoskeletal Tumor Society score. Best results were observed in children with an endoprosthesis of the distal femur who achieved as much as 90% ability to do their daily life routine. Limb-saving therapy in children with osteosarcoma enables a return to activities of daily living in long-term survivors with a minimum of remaining disability.
authors.affiliation: Department of Surgery and Surgical Oncology, Robert Rössle Hospital and Tumor Institute, Max Delbrück Center for Molecular Medicine, Humboldt-University of Berlin Charité, Germany. tunn@rrk.charite-buch.de
authors.forename: Per-Ulf
authors.initials: PU
authors.lastname: Tunn
authors.forename: Peter
authors.initials: P
authors.lastname: Schmidt-Peter
authors.forename: Doreen
authors.initials: D
authors.lastname: Pomraenke
authors.forename: Peter
authors.initials: P
authors.lastname: Hohenberger
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D002648:Child; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006811:Humerus / Q000473:pathology / Q000503:physiopathology; D007867:Leg Bones / Q000473:pathology / Q000503:physiopathology; D023821:Limb Salvage; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery*; D020127:Recovery of Function / Q000502:physiology*; D012189:Retrospective Studies; D013997:Time Factors