"Lock-in"-cycloSal-pronucleotides - a new generation of chemical Trojan Horses?
The cycloSal-concept is one example of a successful nucleotide delivering system (pronucleotide). For several nucleoside analogues, the cycloSal-approach improved the antiviral potency and the applicability of the nucleosides could be broadened. Here, a conceptional extension of the original design of the cycloSal-system will be discussed.
Meier
Chris
C
Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6; D-20146 Hamburg, Germany. chris.meier@chemie.uni-hamburg.de
Ruppel
Manuel F H
MF
Vukadinovic
Dalibor
D
Balzarini
Jan
J
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D054306:Dideoxynucleotides; D006801:Humans; D015394:Molecular Structure; D009711:Nucleotides / Q000737:chemistry* / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013942:Thymine Nucleotides; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; C415254:Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate; D054306:Dideoxynucleotides; D009711:Nucleotides; D011355:Prodrugs; D013942:Thymine Nucleotides; D018119:Stavudine