title: [Inhibitory effects of basic fibroblast growth factor on fibrosis of strain injured skeletal muscles in rats].
abstract: OBJECTIVE
  To investigate the effects of exogenous basic fibroblast growth factor (bFGF) on the healing of strain injured skeletal muscles in rats.
  
  
  METHODS
  Eighteen male SD rats were randomly divided into three groups: no strain control group (C(on)), muscle strained and bFGF treated group (S(b)), or normal saline treated group (S(0)). The gastrocnemius of rats in the S(b) and S(0) groups was strained and the animals were treated with bFGF (200 AU/d) or normal saline for six days. Vimentin expression, an indicator of muscle fibrosis in injured muscles (expressed as integral optical density, IOD), was measured by immunohistochemistry.
  
  
  RESULTS
  The IOD of vimentin in the S(0) group [(24.29 +/- 7.91) x 10(3)] was higher than that in the C(on) group [(5.75 +/- 3.87) x 10(3)] (P < 0.01). The IOD of vimentin in bFGF treated group [(15.78 +/- 7.72) x 10(3)] was lower than that in the normal saline treated group (P < 0.01).
  
  
  CONCLUSIONS
  The exogenous bFGF may facilitate the repair of muscle structure and function by reducing vimentin expression and fibrosis in strain injured muscles.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100083, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Feng
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Guo-zhen
authors.initials: GZ
authors.lastname: Li
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D018482:Muscle, Skeletal / Q000737:chemistry / Q000187:drug effects* / Q000293:injuries; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013180:Sprains and Strains; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D016222:Fibroblast Growth Factor 2