title: Chemoprevention of oral squamous cell carcinomas.
abstract: Among individuals with a history of head and neck cancer and tobacco abuse the risk of second primary cancers in the upper aerodigestive tract is high. Chemoprevention of oral squamous cell carcinomas is based on two conditions: Premalignant mucosa lesions are treated with chemopreventive agents in order to prevent malignant conversion (primary prevention). In secondary prevention of oral cancer, after curative therapy patients are treated by chemoprevention in order to reduce the rate of second primaries. This paper presents a comprehensive clinical review of oral cancer prevention studies, highlighting the agents mostly used, such as beta-carotene, alpha-tocopherol, ascorbic acid, and retinoids. Although most intervention trials showed good overall response with these substances, high relapse rates and serious side effects, in most cases related to the retinoid compounds were noticed. In addition, in all prospective randomized chemoprevention trials (CARET, ATBC and PHS) no significant evidence of benefit for supplementation with alpha-tocopherol, beta-carotene or retinyl palmitate was reported.
authors.affiliation: Department of Craniomaxillofacial and Plastic Surgery, University of Cologne, Germany. m.scheer@uni-koeln.de
authors.forename: M
authors.initials: M
authors.lastname: Scheer
authors.forename: A C
authors.initials: AC
authors.lastname: Kuebler
authors.forename: J E
authors.initials: JE
authors.lastname: Zöller
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000517:prevention & control*; D002338:Carotenoids / Q000627:therapeutic use; D018890:Chemoprevention / Q000379:methods; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000517:prevention & control*; D016609:Neoplasms, Second Primary / Q000188:drug therapy* / Q000517:prevention & control*; D012176:Retinoids / Q000627:therapeutic use; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D012176:Retinoids; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid