title: MicroRNA precursors in motion: exportin-5 mediates their nuclear export.
abstract: The discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).
authors.affiliation: School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Korea. narrykim@snu.ac.kr
authors.forename: V Narry
authors.initials: VN
authors.lastname: Kim
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D028884:Karyopherins / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D028961:beta Karyopherins / Q000235:genetics / Q000378:metabolism*; D020931:ran GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D028884:Karyopherins; D035683:MicroRNAs; D009687:Nuclear Proteins; C446511:XPO5 protein, human; D028961:beta Karyopherins; D020931:ran GTP-Binding Protein