Coriatone and corianlactone, two novel sesquiterpenes from Coriaria nepalensis.
Both coriatone (1). a novel highly oxygenated picrotoxane-type sesquiterpene, and corianlactone (2). with an unprecedented sesquiterpene basic skeleton, named coriane, were isolated from Coriaria nepalensis Wall. The structures of 1 and 2 were determined by analysis of their two-dimensional NMR data, and the structure of 2 was confirmed by X-ray analysis. Compounds 1 and 2 showed no remarkable inhibitory activity toward K(562) cells. They are cytotoxic with IC(50) > 50 microg/mL (cis-platinim: IC(50) = 0.49 microg/mL).
Shen
Yun-Heng
YH
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P. R. China.
Li
Sheng-Hong
SH
Li
Rong-Tao
RT
Han
Quan-Bin
QB
Zhao
Qin-Shi
QS
Liang
Li
L
Sun
Han-Dong
HD
Lu
Yang
Y
Cao
Peng
P
Zheng
Qi-Tai
QT
D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C494533:Coriatone; D007783:Lactones; D012717:Sesquiterpenes; C494534:corianlactone