Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones.
A variety of novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones have been synthesized by reacting (2-methylthio-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with a variety of amines, the starting material dithiocarbamate was synthesized from methylanthranilate. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. While the test compounds exhibited significant activity, the compounds A1, A2, A3 and A4 shown more potent analgesic activity, and the compound A4 shown more potent anti-inflammatory activity than the reference diclofenac sodium.
Alagarsamy
Veerachamy
V
Medicinal Chemistry Laboratory, J.S.S. College of Pharmacy, Mysore, India. samy_veera@yahoo.com
Rajesh
Ramadoss
R
Ramaseshu
Meena
M
Vijaykumar
Sukumaran
S
Ramseshu
Kona Venkat
KV
Duraianandakumar
Thirumoorthy
T
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000379:methods; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology*
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011799:Quinazolines