Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium.
MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella.
van der Straaten
Tahar
T
Department of Infectious Diseases, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. j.t.van_dissel@lumc.nl
Janssen
Riny
R
Mevius
Dik J
DJ
van Dissel
Jaap T
JT
D001426:Bacterial Proteins / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D009154:Mutation / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D010957:Plasmids / Q000235:genetics; D019779:Salmonella enterica / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics
D001426:Bacterial Proteins; C485380:MarA protein, Salmonella enterica; D015534:Trans-Activators; C453342:rma protein, Salmonella