title: In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.
abstract: A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
authors.affiliation: Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. derek.lowe.b@bayer.com
authors.forename: Derek B
authors.initials: DB
authors.lastname: Lowe
authors.forename: Steven
authors.initials: S
authors.lastname: Magnuson
authors.forename: Ning
authors.initials: N
authors.lastname: Qi
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Campbell
authors.forename: James
authors.initials: J
authors.lastname: Cook
authors.forename: Zhenqiu
authors.initials: Z
authors.lastname: Hong
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Mareli
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Furahi
authors.initials: F
authors.lastname: Achebe
authors.forename: Harold
authors.initials: H
authors.lastname: Kluender
authors.forename: Wai C
authors.initials: WC
authors.lastname: Wong
authors.forename: William H
authors.initials: WH
authors.lastname: Bullock
authors.forename: Arthur I
authors.initials: AI
authors.lastname: Salhanick
authors.forename: Terri
authors.initials: T
authors.lastname: Witman-Jones
authors.forename: Mary E
authors.initials: ME
authors.lastname: Bowling
authors.forename: Christine
authors.initials: C
authors.lastname: Keiper
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Clairmont
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D007555:Isoxazoles / Q000737:chemistry* / Q000494:pharmacology; D002787:Sterol Esterase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007555:Isoxazoles; D014508:Urea; D002787:Sterol Esterase