Presynaptic AMPA receptors: more than just ion channels?
AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic function. We discuss here the possibility that not only ion influx through the receptor, but also biochemical cascades, activated by ligand binding and independent from ion flux, might contribute to AMPA mediated presynaptic modulation.
Schenk
Ursula
U
Department of Medical Pharmacology, CNR Institute of Neuroscience, Cellular and Molecular Pharmacology, Center of Excellence for Neurodegenerative Diseases, 20129 Milano, Italy. u.schenk@in.cnr.it
Matteoli
Michela
M
D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008024:Ligands; D008954:Models, Biological; D017729:Presynaptic Terminals / Q000378:metabolism*; D018091:Receptors, AMPA / Q000378:metabolism*; D017470:Receptors, Glutamate / Q000378:metabolism; D015398:Signal Transduction; D009435:Synaptic Transmission; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
D007473:Ion Channels; D008024:Ligands; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D018698:Glutamic Acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid