title: Nasopharyngeal carcinoma tumor volume measurement..
abstract: Tumor volume was measured in 69 patients with nasopharyngeal carcinoma. On transverse nonenhanced T1-weighted and gadolinium-enhanced T1-weighted magnetic resonance (MR) images, segmentation was performed by means of seed growing and knowledge-based fuzzy clustering methods. Data were compared with those collected with the manual tracing method and analyzed for interoperator variance and interobserver reliability. There was no significant difference between the volumes determined with manual tracing or semiautomated segmentation (P >.05). On the volume level, Pearson correction coefficients were close for both the manual tracing and semiautomated methods. Significant differences in interoperator variance existed between the two methods on the pixel level (P <.05). Compared with manual tracing, the semiautomated method helped reduce interoperator variance and obtain higher interobserver reliability. Findings in the current study validate the use of semiautomated volume measurement methods for nasopharyngeal carcinoma.
authors.affiliation: Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore. gdrcfh@sgh.com.sg
authors.forename: Vincent F H
authors.initials: VF
authors.lastname: Chong
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Zhou
authors.forename: James B K
authors.initials: JB
authors.lastname: Khoo
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Tuan-Kay
authors.initials: TK
authors.lastname: Lim
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009305:Nasopharynx / Q000473:pathology; D015588:Observer Variation; D019047:Phantoms, Imaging; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D005682:Gadolinium