title: Changes in blood viscosity with mucopolysaccharide polysulfate.
abstract: We examined the dose-dependent effects of mucopolysaccharide polysulfate (MPS) on coagulation variables and whole-blood viscosity in human blood. Both 0.01% and 0.1% MPS significantly reduced levels of both fibrin monomer and thrombin-antithrombin III complex in a manner similar to that of 2.0 IU/ml heparin sodium. Furthermore, MPS dose-dependently decreased whole-blood viscosity, as measured with an oscillation viscometer. Because MPS can be applied in creams and gels, percutaneous application of MPS may effectively reduce whole-blood viscosity in local veins.
authors.affiliation: Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan. hitosugi@dokkyomed.ac.jp
authors.forename: Masahito
authors.initials: M
authors.lastname: Hitosugi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Omura
authors.forename: Masahito
authors.initials: M
authors.lastname: Kido
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawato
authors.forename: Munehiro
authors.initials: M
authors.lastname: Niwa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nagai
authors.forename: Shogo
authors.initials: S
authors.lastname: Tokudome
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D001809:Blood Viscosity / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006801:Humans; D008297:Male
chemical_list: D006025:Glycosaminoglycans; C052717:mucopolysaccharide polysulfate