title: Prenylindoles from Tanzanian Monodora and Isolona species.
abstract: 6-(3-Methyl-but-2-enyl)-1,3-dihydro-indol-2-one, annonidine F [3-[6-(3-methyl-but-2-enyl)-1H-indolyl]-6-(3-methyl-but-2-enyl)-1H-indole], 1H-indole-5-carbaldehyde, 6-(3-methyl-2-butenyl)-1H-indole, 6-(3-methyl-buta-1,3-dienyl)-1H-indole, 6-(4-oxo-but-2-enyl)-1H-indole and 3-geranylindole were isolated from Monodora angolensis (Annonaceae) while 3-(1,1-dimethyl-but-2-enyl)-5-(3-methyl-but-2-enyl)-1H-indole (caulidine A), 4-[3-(1,1-dimethyl-but-2-enyl)-1H-indol-5-yl]-but-3-en-2-one (caulidine B), 5-(3-methyl-2-butenyl)-1H-indole and 5-(3-methylbuta-1,3-dienyl)-1H-indole were obtained from Isolona cauliflora (Annonaceae); structural determination by spectroscopic analysis. Some of the prenylindoles had antifungal and antimalarial activities.
authors.affiliation: Department of Chemistry, University of Dar es Salaam, PO Box 35061, Dar es Salaam, Tanzania. Nkunya@chem.udsm.ac.tz
authors.forename: Mayunga H H
authors.initials: MH
authors.lastname: Nkunya
authors.forename: John J
authors.initials: JJ
authors.lastname: Makangara
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Jonker
mesh_terms: D029061:Annonaceae / Q000737:chemistry*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology*; D013636:Tanzania
chemical_list: D000935:Antifungal Agents; D000962:Antimalarials; D007211:Indoles