Unusually long target site duplications flanking some of the long terminal repeats of human endogenous retrovirus K in the human genome.
Human endogenous retroviruses (HERVs) make up a substantial part of the human genome. HERVs and solitary long terminal repeats (solo LTRs) are usually flanked by 4-6 nt short direct repeats through the well-known mechanism of their integration. A number of solo LTRs flanked by unusually long direct repeats were detected in the human genome. These unusual structures might be a product of an alternative virus insertion mechanism.
Mamedov
Ilgar Z
IZ
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russia.
Lebedev
Yuri B
YB
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russia.
Sverdlov
Eugene D
ED
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russia.
D020077:Endogenous Retroviruses / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D020079:Terminal Repeat Sequences; D016662:Virus Integration