title: Various approaches to modify biomaterial surfaces for improving hemocompatibility.
abstract: In this paper, the mechanism of thrombus formation on the surface of polymeric materials and the various approaches of modifying biomaterial surfaces to improve their hemocompatibility are reviewed. Moreover, the blood compatibility of the cellulose membrane grafted with O-butyrylchitosan (OBCS) by using a radiation grafting technique was studied. Surface analysis of grafted cellulose membrane was verified by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA), which confirmed that OBCS was successfully grafted onto the cellulose membrane surfaces. Blood compatibility of the grafted cellulose membranes was evaluated by platelet rich plasma (PRP) contacting experiments and protein adsorption experiments using blank cellulose membranes as the control. The blood compatibility of OBCS grafted cellulose membranes is better than that of blank cellulose membranes. These results suggest that the photocrosslinkable chitosan developed here has the potential of serving in blood-contacting applications in medical use.
authors.affiliation: Research Center of Surface and Interface Chemical and Engineering Technology, Nanjing University, Hankou Road 22, Nanjing 210093, PR China.
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.forename: Yongzhi
authors.initials: Y
authors.lastname: Qiu
authors.forename: Haibo
authors.initials: H
authors.lastname: Sang
authors.forename: Hua
authors.initials: H
authors.lastname: Mei
authors.forename: Aiping
authors.initials: A
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
authors.forename: Sicong
authors.initials: S
authors.lastname: Lin
mesh_terms: D000327:Adsorption; D000818:Animals; D001769:Blood; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism; D002448:Cell Adhesion; D002482:Cellulose / Q000737:chemistry / Q000378:metabolism*; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D002686:Chitin; D002482:Cellulose; D048271:Chitosan