Microbial hydroxylation of indole to 7-hydroxyindole by Acinetobacter calcoaceticus strain 4-1-5.
A screening study yielded Acinetobacter calcoaceticus strain 4-1-5, which is capable of hydroxylating indole to 7-hydroxyindole. Strain 4-1-5 grew on terephthalate as the sole source of carbon and energy and hydroxylated indole to 7-hydroxyindole by cometabolism of indole using terephthalate as cosubstrate. Strain 4-1-5 produced 0.574 mM of 7-hydroxyindole at 2.38 mM indole in 24 h with the cell growth.
Sugimori
Daisuke
D
Department of Chemistry and Biology Engineering, Fukui National College of Technology, Fukui, Japan. sugimori@fukui-nct.ac.jp
Sekiguchi
Takanori
T
Hasumi
Fumihiko
F
Kubo
Motoki
M
Shirasaka
Naoki
N
Ikunaka
Masaya
M
D016954:Acinetobacter calcoaceticus / Q000378:metabolism*; D001673:Biodegradation, Environmental; D006900:Hydroxylation; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism*
C494864:7-hydroxyindole; D007211:Indoles; C030374:indole