title: [Synthesis and immunomodulating activity of new diglycopeptides of of glycyrrhizinic acid and it's 30-methyl ester].
abstract: New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
authors.affiliation: Bashkortostan State Medical University, Ufa, Bashkortostan, 450074 Russia.
authors.forename: R M
authors.initials: RM
authors.lastname: Kondratenko
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: E V
authors.initials: EV
authors.lastname: Vasil'eva
authors.forename: Kh M
authors.initials: KhM
authors.lastname: Nasyrov
authors.forename: R M
authors.initials: RM
authors.lastname: Kireeva
authors.forename: N Zh
authors.initials: NZh
authors.lastname: Baschenko
authors.forename: S M
authors.initials: SM
authors.lastname: Fridman
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004987:Ethers / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice
chemical_list: D000276:Adjuvants, Immunologic; D004987:Ethers; D006020:Glycopeptides; D019695:Glycyrrhizic Acid