title: Modal damping for monitoring bone integrity and osteoporosis.
abstract: We applied a noninvasive method to assess bone structural integrity. The method is based on the measurement of the dynamic characteristics of the bone (quality factor and modal damping factor) by applying vibration excitation in the range of acoustic frequencies, in the form of an acoustic sweep signal. Excised sheep femora were tested to detect changes in modal damping, density (kg/m3), bone mineral density (kg/m2) and bone mineral (hydroxyapatite) percentage. The changes were recorded after each time of chemical treatment of the bones performed to gradually cause mineral removal, thus simulating osteoporosis. It was shown that the change in quality factor and damping was in all cases on average equal or greater to the change in all other measured characteristics, thus strengthening the potential of the proposed method to become a valuable assessment tool for monitoring bone integrity and osteoporosis.
authors.affiliation: Department of Mechanical Engineering and Aeronautics, University of Patras, GR-26500, Patras, Greece. panteliu@mech.upatras.gr
authors.forename: Sofia D
authors.initials: SD
authors.lastname: Panteliou
authors.forename: Agathi L
authors.initials: AL
authors.lastname: Xirafaki
authors.forename: Elias
authors.initials: E
authors.lastname: Panagiotopoulos
authors.forename: John N
authors.initials: JN
authors.lastname: Varakis
authors.forename: Nikos V
authors.initials: NV
authors.lastname: Vagenas
authors.forename: Christos G
authors.initials: CG
authors.lastname: Kontoyannis
mesh_terms: D000162:Acoustics; D000818:Animals; D015519:Bone Density; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004548:Elasticity; D005269:Femur / Q000503:physiopathology*; D066298:In Vitro Techniques; D008954:Models, Biological; D010024:Osteoporosis / Q000175:diagnosis* / Q000503:physiopathology*; D010808:Physical Examination / Q000379:methods*; D010812:Physical Stimulation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012756:Sheep; D014732:Vibration; D014783:Viscosity