[Effects of Shenshuai Yangzhen capsule on lipid metabolism disorder in rats with chronic renal failure].
OBJECTIVE
To investigate the therapeutic effect of Shenshuai Yangzhen capsule, a preparation of traditional Chinese medicine, on lipid metabolism disorder in rats with chronic renal failure (CRF) and explore its mechanism.


METHODS
Fifty male SD rats received 5/6 nephrectomy for preparation of CRF models and were randomized into CRF group, gemfibrozil group, high-, moderate- and low-dose Shenshuai Yangzhen groups, and normal control group. After 4-week treatment as indicated, myocardial lipoprotein lipase messenger RNA (LPL mRNA) level were measured by RT-PCR in rats with surgically induced renal failure (two-stage subtotal nephrectomy). The blood lipid parameters in CRF rats were also determined.


RESULTS
Compared with those in the CRF group, the plasma total cholesterol, triglyceride, low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol concentrations in the treatment groups were significantly lower with substantially elevated plasma high-density lipoprotein cholesterol and LPL gene expression. No significant differences were noted between different dose groups of Shenshuai Yangzhen.


CONCLUSIONS
Shenshuai Yangzhen capsule can regulate blood lipid levels in rats with renal insufficiency possibly by enhancing LPL gene expression.
Li
Yu-ming
YM
Department of Traditional Chinese Medicine, Zhujiang Hospital, First Military Medical University, Guangzhou 510515, China. lymfeng@163.net
Wei
Lian-bo
LB
Yuan
Gang
G
Ma
Zhi-gang
ZG
Huang
Lin
L
D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics; D008297:Male; D009206:Myocardium / Q000201:enzymology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D002214:Capsules; D004365:Drugs, Chinese Herbal; D008055:Lipids; D012333:RNA, Messenger; D008071:Lipoprotein Lipase