title: Treatment of extensive chronic cutaneous graft-versus-host disease in an infant with topical pimecrolimus.
abstract: We report a case of generalized cutaneous chronic graft-versus-host disease in a 17-month-old infant. Topical treatment with the novel ascomycin substance pimecrolimus once daily for 4 weeks led to a near complete clearance of skin lesions. Importantly, this excellent clinical response was obtained without additional use of systemic immunosuppressive treatment.
authors.affiliation: Department of Dermatology, University of Jena, Jena, Germany. Mirjana.Ziemer@derma.uni-jena.de
authors.forename: Mirjana
authors.initials: M
authors.lastname: Ziemer
authors.forename: Bernd
authors.initials: B
authors.lastname: Gruhn
authors.forename: Jens J
authors.initials: JJ
authors.lastname: Thiele
authors.forename: Peter
authors.initials: P
authors.lastname: Elsner
mesh_terms: D000287:Administration, Topical; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects; D012871:Skin Diseases / Q000188:drug therapy*; D016559:Tacrolimus / Q000009:adverse effects* / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D016559:Tacrolimus