Acetaminophen-induced toxic epidermal necrolysis in a child.
Toxic epidermal necrolysis (TEN) is a severe, life-threatening disorder that usually affects adults. It is often drug induced. We report an instance of a severe case of TEN in a 6-year-old boy, probably induced by acetaminophen, and less likely by codeine. A lymphocyte stimulation test could not identify the culprit drug. Treatment with intravenous immunoglobulin seemed to halt the disease progression.
Bygum
Anette
A
Department of Dermatology, Aarhus Amtssygehus, Skejby Hospital, Aarhus, Denmark.
Gregersen
Jon Waarst
JW
Buus
Sanne Krogsbøll
SK
D000082:Acetaminophen / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology*
D018712:Analgesics, Non-Narcotic; D016756:Immunoglobulins, Intravenous; D000082:Acetaminophen