title: Pringle's maneuver and selective inflow occlusion in living donor liver hepatectomy.
abstract: While inflow occlusion techniques such as Pringle's maneuver are accepted methods of reducing bleeding without inducing liver injury during liver surgery, donor hepatectomy for living donor liver transplantation is currently performed without inflow occlusion for fear that injury to the graft may result. We have performed donor hepatectomy for 12 years using selective intermittent inflow occlusion, a technique in which the portion used to form the graft is perfused during hepatectomy. Starting in November 2000, we applied intermittent Pringle's maneuver to donor hepatectomy in 81 cases of living donor liver transplantation. We reviewed our experience with Pringle's maneuver and selective inflow occlusion techniques in donor hepatectomy in living donor liver transplantation. The quality of the grafts was assessed and compared by determining maximum postoperative aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values. Neither primary nonfunction nor dysfunction occurred. Maximum AST values in the recipients were the same whether the liver segments that formed the grafts were totally ischemic during dissection (total ischemia), partially ischemic (partial ischemia), perfused only with arterial blood flow (portal ischemia), or not ischemic at all (no ischemia). Maximum ALT values in the recipients of the total ischemia group was lower, albeit not significantly, than in other groups. Total inflow occlusion can be applied to living donor hepatectomy without causing graft injury. In conclusion, because the transection surface is blood-free, there is decreased risk to the donor during living donor liver transplantation surgery, and surgeons should not hesitate to apply this technique because it contributes to donor safety.
authors.affiliation: Division of Hepatobiliary-Pancreatic Surgery and Artificial Organ and Transplantation Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. himamura-tky@umin.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kokudo
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sugawara
authors.forename: Keiji
authors.initials: K
authors.lastname: Sano
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kaneko
authors.forename: Tadatoshi
authors.initials: T
authors.lastname: Takayama
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D003250:Constriction; D005260:Female; D006488:Hemostasis, Surgical / Q000379:methods*; D006498:Hepatectomy; D006499:Hepatic Artery / Q000503:physiopathology; D006801:Humans; D007432:Intraoperative Period; D008099:Liver / Q000201:enzymology; D008102:Liver Circulation; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020858:Tissue and Organ Harvesting
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase