title: Neurosurgical reconstruction with acellular cadaveric dermal matrix.
abstract: Acellular cadaveric dermal matrix (ACDM) is processed from human cadaver skin (AlloDerm; Life Cell Corp., Branchburg, NJ). It does not require an immediate blood supply but can transmit essential interstitial fluids for nourishment of overlying tissues. A number of neurosurgical reconstructions have required the use of tissue that fills these specifications. The material has been used most recently for reconstruction of dura during craniotomies when primary closure is not possible or harvesting from an autologous site is not available. Because ACDM is harvested from nonneurologic cadaveric tissues and because the cellular and antigenic elements have been removed from the matrix, prion diseases are not a transmission risk. We present 6 examples of previously unreported uses of ACDM for successful repair of meningomyelocele, cauda equina, encephalocele, cerebrospinal fluid fistula, and neuroma. We propose the use of ACDM as a valuable tool in neurosurgical reconstruction.
authors.affiliation: Department of Surgery, Division of Plastic Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, 07103, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Agag
authors.forename: Mark S
authors.initials: MS
authors.lastname: Granick
authors.forename: Michael
authors.initials: M
authors.lastname: Omidi
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Catrambone
authors.forename: Joseph
authors.initials: J
authors.lastname: Benevenia
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000601:surgery*; D002102:Cadaver; D003094:Collagen / Q000627:therapeutic use*; D004677:Encephalocele / Q000601:surgery*; D005260:Female; D005385:Fingers; D006428:Hemipelvectomy; D006801:Humans; D007085:Ilium; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele / Q000601:surgery*; D009463:Neuroma / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D013529:Surgical Wound Dehiscence / Q000601:surgery*; D014945:Wound Healing / Q000502:physiology
chemical_list: C440568:Alloderm; D003094:Collagen