[The antitumor effect of DNL/rIL-2 and Pingyangmycin on human tongue carcinoma(Tca 8113) transplanted to Nude Mice]
We have tried to find out if the combination of DNL/rIL-2 and antitumor drug is able to induce a synergistic increase in the antitumor therapeutic effect.DNL were obtained from the patients who suffered from primary tongue cancer were been performed operation of radical neck dissection.When the ratio of the effectors to the targets was 5:1 with local administration,rIL-2 5x10(5)Kg/d and PYM 5mg kg/d ip administration,the inhibitory rate of tumor growth was 86%.The results showed a significant rate increase when compared with the therpeutic effect obtained by DNL/rIL-2,or PYM alone (P<0.05).In addition,we used Burgi formula to evaluated the antitumor effect of DNL/rIL-2 combined with PYM.The q value was 1.46.These results suggest that immunotherapy and chemotherapy perhaps function synergistically.
Guo
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Department of Oral and Maxillofacial Surgery,School of Stomatology,Shanghai Second Medical University.Shanghai 200011, China.
He
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Zhang
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ZY