title: [Morphological evidence on participating in adhesive function of human umbilical vein endothelial cells by CD226].
abstract: OBJECTIVE
  To provide the morphological evidence on participating in the adhesive function of human umbilical vein endothelial cells by CD226.
  
  
  METHODS
  Human umbilical vein endothelial cells(HUVECs) were cultured and the effect of CD226 on the adhesion between activated HUVEC and activated PBMC were observed by Leica inverted microscope and scanning electron microscope.
  
  
  RESULTS
  Fusion protein CD226/Ig could block the adhesion between activated HUVECs and activated PBMC markedly.
  
  
  CONCLUSIONS
  CD226 was a novel inducible adhesion molecule expressed on activated endothelial cells, which may possess important physiological and pathological function.
authors.affiliation: Department of Immunology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Chen
authors.forename: Xin-Hai
authors.initials: XH
authors.lastname: Zhang
authors.forename: Yi-Chao
authors.initials: YC
authors.lastname: She
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Liu
authors.forename: Bo-Quan
authors.initials: BQ
authors.lastname: Jin
mesh_terms: D000269:Adhesives; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism
chemical_list: D000269:Adhesives; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1