title: [The effectiveness of cevimeline hydrochloride on dry cough in Sjögren's syndrome].
abstract: Dry cough in Sjögren syndrome (SS) is not an uncommon symptom observed in clinical fields. However, effective treatments for the cough have not been established. The recently introduced cevimeline hydrochloride, a muscarinic receptor stimulant, has been confirmed to be definitely effective for xerostomia of SS. In the present study, the effectiveness of cevimeline hydrochloride on dry cough was studied in 9 Sjögren patients and evaluated using the visual analog scale (VAS) and face scale. Improvement of dry cough was observed in 8 out of the 9 patients, suggesting the effectiveness of cevimeline hydrochloride. Although the detailed etiology of dry cough in SS is unknown, the result of the study suggested the mechanism that cevimeline hydrochloride increased the secretion in the airway mucus, improving dry bronchial conditions. Further studies are needed with more subjects.
authors.affiliation: Department of Rheumatology, Taga General Hospital.
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishinarita
authors.forename: Midori
authors.initials: M
authors.lastname: Hanzawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Iikuni
authors.forename: Syuji
authors.initials: S
authors.lastname: Ota
mesh_terms: D000328:Adult; D000368:Aged; D003371:Cough / Q000188:drug therapy*; D015352:Dry Eye Syndromes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000627:therapeutic use*; D011812:Quinuclidines / Q000627:therapeutic use*; D012859:Sjogren's Syndrome / Q000188:drug therapy*; D013876:Thiophenes
chemical_list: D018721:Muscarinic Agonists; D011812:Quinuclidines; D013876:Thiophenes; C059240:cevimeline