title: Trypanocidal properties of Mikania stipulacea and Mikania hoehnei isolated terpenoids.
abstract: The in vitro trypanocidal properties of isolated terpenoids from Mikania stipulacea and Mikania hoehnei were investigated in Trypanosoma cruzi Y strain. Both compounds, the diterpene ent-9alpha-hydroxy-15beta-E-cinnamoyloxy-16-kauren-19-oic acid (1) and the sesquiterpene lactone 8beta-hydroxyzaluzanin D (2) were active.
authors.affiliation: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n, 14040-903 Ribeirão Preto, SP, Brazil.
authors.forename: Andréa Mendes
authors.initials: AM
authors.lastname: do Nascimento
authors.forename: Juliana
authors.initials: J
authors.lastname: Siqueira Chaves
authors.forename: Sérgio
authors.initials: S
authors.lastname: Albuquerque
authors.forename: Dionéia Camilo
authors.initials: DC
authors.lastname: Rodrigues de Oliveira
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000517:prevention & control; D006801:Humans; D035742:Mikania; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D013729:Terpenes; D014344:Trypanocidal Agents