title: Epithelioid malignant peripheral nerve sheath tumour in a dog.
abstract: An unusual morphological variant of malignant peripheral nerve sheath tumour, in which the cells exhibited a predominantly epithelial morphology, was diagnosed in a dog. The animal had a history of progressive ataxia. Post-mortem examination revealed an infiltrative growth in the sublumbar region, encroaching on the L1 and L2 vertebral bodies; additional masses were observed in the kidneys, liver and lungs. Histologically, the subcutaneous mass was composed of a dense population of spindle-shaped cells arranged in fascicles. The internal masses were composed of epithelioid cells arranged in a nodular pattern. Immunohistochemically, the spindle-shaped cells of the subcutaneous mass were positive for S-100, and the epithelioid cells of the internal growths exhibited weak S-100 immunoreactivity.
authors.affiliation: Department of Animal Pathology II, Veterinary School, Universidad Complutense de Madrid, Madrid E-28040, Spain.
authors.forename: P
authors.initials: P
authors.lastname: García
authors.forename: B
authors.initials: B
authors.lastname: Sánchez
authors.forename: M A
authors.initials: MA
authors.lastname: Sánchez
authors.forename: M
authors.initials: M
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: Rollán
authors.forename: J M
authors.initials: JM
authors.lastname: Flores
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004285:Dogs; D015622:Epithelioid Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D007150:Immunohistochemistry; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000662:veterinary*