Efficient, "tin-free" radical cyclization to aromatic systems. synthesis of 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinolines.
Efficient radical cyclization of alkyl iodides to various aromatic systems including pyrrole, indole, isoquinolone, pyridone, and benzene, mediated by dicumyl peroxide, is described. The methodology was used to provide access to 5,6,8,9,10,11-hexahydroindolo[2,1-a]isoquinoline derivatives.
Menes-Arzate
Martha
M
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán, México D. F. 04510, Mexico.
Martínez
Roberto
R
Cruz-Almanza
Raymundo
R
Muchowski
Joseph M
JM
Osornio
Yazmin M
YM
Miranda
Luis D
LD