Trypanocidal activity of chemical constituents from Lychnophora salicifolia Mart.
The ethyl acetate extract from leaves plus inflorescences of L. salicifolia showed significant trypanocidal activity against trypomastigote forms of T. cruzi, which was due to the flavonoid quercetin-7,3',4'-trimethyl ether and the sesquiterpenoid lychnopholic acid. Despite the use of some species of Lychnophora in folk medicine for pain relief, crude extracts from L. salicifolia Mart. showed no antinociceptive activity in the mouse writhing test.
Jordão
Christiane Oliveira
CO
Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Ribeirao Preto, SP, Brazil.
Vichnewski
Walter
W
de Souza
Glória Emília Petto
GE
Albuquerque
Sérgio
S
Lopes
João Luis Callegari
JL
D000818:Animals; D019659:Asteraceae; D014355:Chagas Disease / Q000517:prevention & control; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
D010936:Plant Extracts; D014344:Trypanocidal Agents