[Immunohistochemical observation of heart-type fatty acid binding-protein in early myocardial ischemia].
OBJECTIVE
The sensitivity of heart-type fatty acid binding-protein (H-FABP) in the postmortem diagnosis of myocardial ischemia was explored.


METHODS
The changes of H-FABP staining in normal, infarcted and suspected ischemia of myocardial cells were studied by immunohistochemistry.


RESULTS
There was no depletion in normal control group, and obvious depletion was observed in myocardial infarcted group. Among 9 suspected myocardial ischemia group, 3 cases showed obvious depletion and 3 cases showed vague depletion for H-FABP, there were obvious depletion of Mb in 4 suspected myocardial ischemia cases and vague depletion in 2 cases for Mb. It is indicated that H-FABP can be used to diagnose early myocardial ischemia.


CONCLUSIONS
H-FABP is quite sensitive and useful for the diagnosis of early myocardial ischemia.
Ming
Mei
M
Department of Forensic Medicine, School of Medicine, Wuhan University, Wuhan 430071, China. monkmm@sina.com
Meng
Xiang-zhi
XZ
D015415:Biomarkers / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis*; D003402:Creatine Kinase / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D007150:Immunohistochemistry; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009211:Myoglobin / Q000378:metabolism; D012680:Sensitivity and Specificity
D015415:Biomarkers; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D009211:Myoglobin; D003402:Creatine Kinase