Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus.
Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.
Ender
Miriam
M
Department of Medical Microbiology, University of Zürich, Gloriastr. 32, CH8028 Zürich, Switzerland.
McCallum
Nadine
N
Adhikari
Rajan
R
Berger-Bächi
Brigitte
B
D015169:Colony Count, Microbial; D015257:DNA-Cytosine Methylases / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D020071:Interspersed Repetitive Sequences / Q000235:genetics; D016106:Methicillin Resistance / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development*; D014169:Transformation, Bacterial / Q000235:genetics
D010406:Penicillins; C079006:DNA modification methylase XcyI; D015257:DNA-Cytosine Methylases; D010068:Oxacillin