title: Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.
abstract: A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC(50) of 0.21 and 0.23 microM, respectively.
authors.affiliation: State key laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Zhangjiang High-Tech Park, Shanghai 201203, China.
authors.forename: Xiao-Chun
authors.initials: XC
authors.lastname: Huang
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
authors.forename: Hou-Ming
authors.initials: HM
authors.lastname: Wu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Lin
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Ding
authors.forename: Yong-Shui
authors.initials: YS
authors.lastname: Lin
mesh_terms: D000475:Alkenes / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000302:isolation & purification* / Q000494:pharmacology*; D004141:Dinoflagellida; D018922:HL-60 Cells; D006801:Humans; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000475:Alkenes; D003603:Cytotoxins; D011714:Pyrans