title: The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities.
abstract: We compared the abilities of trans-resveratrol and seven analogs to inhibit an azo compound-induced peroxidation of linoleic acid in vitro and to induce apoptosis in cultured human leukemia cells. The results showed that both the antioxidant and apoptotic activities of the analogs containing 3,4-dihydroxyl groups were significantly higher than those of the trans-resveratrol and the other analogs. Hence, the 3,4-dihydroxyl groups were important for trans-resveratrol analogs to exhibit concurrent high antioxidant and apoptotic activities.
authors.affiliation: National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China.
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Cai
authors.forename: Qing-Yi
authors.initials: QY
authors.lastname: Wei
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Fang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Zhong-Li
authors.initials: ZL
authors.lastname: Liu
authors.forename: James H
authors.initials: JH
authors.lastname: Wyche
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Han
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001391:Azo Compounds / Q000737:chemistry; D018922:HL-60 Cells; D006801:Humans; D019169:Jurkat Cells; D019787:Linoleic Acid / Q000737:chemistry / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001391:Azo Compounds; D013267:Stilbenes; D019787:Linoleic Acid; D000077185:Resveratrol