title: [A case of poorly differentiated lung adenocarcinoma showing air-space consolidation caused by aerogenic metastasis].
abstract: A 78-year-old woman was admitted to our hospital because of dyspnea. A chest radiograph and a computed tomogram on admission showed air-space consolidation in the left upper lung field, and so pneumonia was diagnosed. Although antibiotics were administered, the air-space consolidation did not improve. A transbronchial lung biopsy was performed, yielding a pathologic diagnosis of poorly differentiated lung adenocarcinoma. Despite combination chemotherapy with docetaxel and UFT, the air-space consolidation expanded, and the patient finally died of respiratory failure 3 months after diagnosis. Autopsy revealed air-space consolidation due to poorly differentiated lung adenocarcinoma, with large atypical cells diffusely floating in the alveolar spaces. It has been recognized that bronchiolo-alveolar carcinoma and well-differentiated lung adenocarcinoma present with air-space consolidation, reflecting the cancer cells lining the alveolar walls. However, in this case, the air-space consolidation was due to cancer cells diffusely floating in the alveolar spaces in aerogenic metastasis. It was considered that this is a rare case, which presented with a very interesting development pattern.
authors.affiliation: Division of Respiratory Disease, Kawasaki Medical School, Kawasaki Hospital, 2-1-80, Nakasange, Okayama 700-8505, Japan.
authors.forename: Kazue
authors.initials: K
authors.lastname: Fujita
authors.forename: Takeyuki
authors.initials: T
authors.lastname: Kurihara
authors.forename: Hideo
authors.initials: H
authors.lastname: Ohba
authors.forename: Junichi
authors.initials: J
authors.lastname: Nakamura
authors.forename: Niro
authors.initials: N
authors.lastname: Okimoto
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000368:Aged; D000388:Air; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D009361:Neoplasm Invasiveness; D013902:Radiography, Thoracic