The involvement of the orbitofrontal cortex in the experience of regret.
Facing the consequence of a decision we made can trigger emotions like satisfaction, relief, or regret, which reflect our assessment of what was gained as compared to what would have been gained by making a different decision. These emotions are mediated by a cognitive process known as counterfactual thinking. By manipulating a simple gambling task, we characterized a subject's choices in terms of their anticipated and actual emotional impact. Normal subjects reported emotional responses consistent with counterfactual thinking; they chose to minimize future regret and learned from their emotional experience. Patients with orbitofrontal cortical lesions, however, did not report regret or anticipate negative consequences of their choices. The orbitofrontal cortex has a fundamental role in mediating the experience of regret.
Camille
Nathalie
N
Institut des Sciences Cognitives, CNRS, 67, Boulevard Pinel 69675 Bron, France.
Coricelli
Giorgio
G
Sallet
Jerome
J
Pradat-Diehl
Pascale
P
Duhamel
Jean-René
JR
Sirigu
Angela
A
D000328:Adult; D001927:Brain Diseases / Q000503:physiopathology / Q000523:psychology; D002755:Choice Behavior; D003657:Decision Making; D004644:Emotions; D030141:Feedback, Psychological; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D005712:Galvanic Skin Response; D005715:Gambling; D006801:Humans; D008297:Male; D008875:Middle Aged; D008960:Models, Psychological; D013850:Thinking