title: [The unity of systemic pathogenetic mechanisms in visceral diseases associated with generalized periodontitis].
abstract: The authors analyzed published data and their own findings which confirm the unity of systemic mechanisms of pathogenesis in combined visceral diseases and generalized periodontitis. The data proving the pathogenetic role of free-radical oxidation of lipids, proteins, and low-molecular-weight thiols, immunological imbalances, and deficiencies of the major macro- and trace elements (Ca, Mg, K, Na, Zn, Cu, Fe) are presented. The detected metabolic disorders and homeostatic shifts characterize the universal processes mediating alteration of cell structures in different organs and tissues in combined diseases.
authors.forename: I A
authors.initials: IA
authors.lastname: Gorbacheva
authors.forename: A I
authors.initials: AI
authors.lastname: Kirsanov
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Orekhova
mesh_terms: D000368:Aged; D000917:Antibody Formation; D002318:Cardiovascular Diseases / Q000453:epidemiology; D015897:Comorbidity; D004066:Digestive System Diseases / Q000453:epidemiology; D006801:Humans; D007111:Immunity, Cellular; D015227:Lipid Peroxidation; D008659:Metabolic Diseases / Q000453:epidemiology; D008670:Metals / Q000097:blood; D008875:Middle Aged; D010518:Periodontitis / Q000453:epidemiology* / Q000276:immunology / Q000378:metabolism
chemical_list: D008670:Metals