Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle.
The pharmacokinetics of the new triamilide antibiotic tulathromycin was investigated in two cattle studies. Following a single subcutaneous injection, the drug was rapidly absorbed and bioavailability was excellent. High and persistent levels of the drug in lung tissue were observed as well. These attributes are advantageous for an antimicrobial drug indicated for the treatment of bacterial and mycoplasmal respiratory diseases in cattle.
Nowakowski
Marcus A
MA
Pfizer Global Research and Development, Groton Laboratories, Veterinary Medicine Safety and Metabolism Group, Eastern Point Road, Groton, CT 06340, USA.
Inskeep
Philip B
PB
Risk
Jim E
JE
Skogerboe
Terry L
TL
Benchaoui
Hafid A
HA
Meinert
Todd R
TR
Sherington
John
J
Sunderland
Simon J
SJ
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002417:Cattle / Q000378:metabolism*; D004187:Disaccharides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008168:Lung / Q000378:metabolism*; D008297:Male; D018942:Macrolides
D000890:Anti-Infective Agents; D004187:Disaccharides; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides