[Effect of age on absorption and membrane digestion in the rat small intestine].
By the short-circuit current method in our modification, kinetic constants for nutrient transporters in rat gastric-intestinal tract and unstirred layer thickness near mucosa surface, were studied. In experiments on rats it was shown that in ageing, the nutrient monomer transporters number in the small intestine increases twofold, while its affinity to correspondent nutrients remains unchanged. For the peptide the situation may be the opposite one. The layer thickness in the vicinity of mucosa surface measured by glucose decreased in ageing. It was suggested that in old rats the role of volume digestion is enhanced resulting in adapting increase of nutrient monomer transporters number.
Metel'skiĭ
S T
ST
Central Research Institute of Gastroenterology, Moscow, 111123, 86 Shosse Entuziastov, Russia.
D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000465:Algorithms; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D004058:Diffusion; D004063:Digestion / Q000502:physiology*; D004553:Electric Conductivity; D020895:Enterocytes / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000166:cytology / Q000378:metabolism; D007421:Intestine, Small / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008320:Maltose / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism*
D000596:Amino Acids; D008320:Maltose; D012964:Sodium; D005947:Glucose