Impact of tobacco smoking on platelet function in apheresis products in vitro.
OBJECTIVE
The aim of this study was to analyse the platelet function, over a 5-day time-period, of apheresis-derived platelet concentrates obtained from smokers and non-smokers.


METHODS
Smoker and non-smoker plateletpheresis products were investigated on days 1, 3 and 5 of storage. Receptor expression (as evaluated by flow cytometry) and the platelet aggregation response were measured.


RESULTS
There was only a slight loss of platelet function in apheresis products from smokers compared to non-smokers.


CONCLUSIONS
Smoking does not significantly change the quality of platelet preparations. The current practice, of not to exclude smokers from platelet donation, can be continued.
Scheinichen
D
D
Department of Anaesthesiology, Hannover Medical School, Hannover, Germany. scheinichen.dirk@mh-hannover.de
Heuft
H-G
HG
Renken
C
C
Jüttner
B
B
Jaeger
K
K
Schürholz
T
T
Blasczyk
R
R
Piepenbrock
S
S
Elsner
H-A
HA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D010980:Platelet Membrane Glycoproteins / Q000032:analysis; D010983:Plateletpheresis; D012907:Smoking / Q000097:blood*
D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine