[Diabetes-associated autoimmune disease in children and juveniles: how important is early recognition?].
Coeliac disease (CD) and autoimmune thyreoiditis (AIT) are associated with type-1 diabetes. These diseases frequently occur without apparent clinical symptoms. Therefore, a serological screening by autoantibody testing is required for early detection. Identified by screening, the prevalence of CD and AIT is reported to be up to 10-fold higher in young patients with type-1 diabetes than in healthy children. Up to now, no uniform recommendations exist regarding a standardized screening procedure as well as the treatment of patients with clinically asymptomatic disorder and evidence of autoimmunity. A delay in the detection of associated diseases, however, may lead to clinical relevant, but otherwise preventable complications.
Kordonouri
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Klinik für Allgemeine Pädiatrie, Otto-Heubner-Centrum für Kinder- und Jugendmedizin, Charité Universitätsmedizin Berlin, Campus Virchow-Klinikum. olga.kordonouri@charite.de
Danne
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D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D006801:Humans; D012307:Risk Factors; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis* / Q000209:etiology
D001323:Autoantibodies