title: The aura-headache connection in migraine: a historical analysis.
abstract: A historical analysis is presented of insights into the pathogenetic mechanisms related to the migraine aura and headache and how the mechanisms connect. In the traditional sequential concept, advanced through the work of Edward Liveing, MD, Harold G. Wolff, MD, and others, the mechanisms are considered causally connected. A noncausal, parallel concept has been proposed as well and is considered in light of the results of recent animal experimental studies.
authors.affiliation: Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.
authors.forename: Egilius L H
authors.initials: EL
authors.lastname: Spierings
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D020325:Migraine with Aura / Q000266:history* / Q000503:physiopathology*; D009462:Neurology / Q000266:history*