Remembering our past: functional neuroanatomy of recollection of recent and very remote personal events.
Functional magnetic resonance imaging was used to study brain regions implicated in retrieval of memories that are decades old. To probe autobiographical memory, family photographs were selected by confederates without the participant's involvement, thereby eliminating many of the variables that potentially confounded previous neuroimaging studies. We found that context-rich memories were associated with activity in lingual and precuneus gyri independently of their age. By contrast, retrosplenial cortex was more active for recent events regardless of memory vividness. Hippocampal activation was related to the richness of re-experiencing (vividness) rather than the age of the memory per se. Remote memories were associated with distributed activation along the rostrocaudal axis of the hippocampus whereas activation associated with recent memories was clustered in the anterior portion. This may explain why circumscribed lesions to the hippocampus disproportionately affect recent memories. These findings are incompatible with theories of long-term memory consolidation, and are more easily accommodated by multiple-trace theory, which posits that detailed memories are always dependent on the hippocampus.
Gilboa
Asaf
A
Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St., Toronto, Ontario, M6A 2E1, Canada. asaf@psych.utoronto.ca
Winocur
Gordon
G
Grady
Cheryl L
CL
Hevenor
Stephanie J
SJ
Moscovitch
Morris
M
D000328:Adult; D000704:Analysis of Variance; D004644:Emotions / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D013997:Time Factors