title: [The effect of FN(fibronectin) on invasion and metastasis of human acinic cell carcinoma cell strain of the salivary gland]
abstract: FN distribution in ACC-2 and high lung-metastatic ACC-M cells was studied with immunohistochemical staining.There were less FN found in ACC-2,but much more FN were observed in the highly metastatic clone Acc-M.In vitro motility of two cell lines was measured by Boyden chamber.With the presence of exgenous FN,Acc-2 became activated with a higher migration rate.The cell adhesion test showed that Acc-2 had stronger ability of adhesion than Acc-M with the presence of FN.The result suggested FN may play a vital role in the invasion and metastasis of ACC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatlolgy, Shanghai Second Medical University. Shanghai 200011, China.
authors.forename: H N
authors.initials: HN
authors.lastname: Shi
authors.forename: R G
authors.initials: RG
authors.lastname: He
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhou