title: Systemic anaplastic large cell lymphoma presenting as a bladder neoplasm.
abstract: Non-Hodgkin's lymphoma is known to involve the bladder, either primarily or secondary. Anaplastic large cell lymphoma has not been documented at this site before. We report a case of a systemic anaplastic cell lymphoma in a 22-year-old man who presented with multisystemic symptoms and signs, including those suggestive of bladder disease. He was HIV-negative. Biopsy of the bladder showed a high grade lymphoma composed of large cells with nuclei containing prominent nucleoli. The tumor cells expressed CD30, CD45, EMA and ALK-1. A diagnosis of anaplastic large cell lymphoma, of null cell phenotype was made. The lymph node biopsy showed similar features on hematoxylin and eosin section. The patient was put on a regime of CHOP and is disease-free 33 months after diagnosis.
authors.affiliation: Department of Pathology, Manipal Hospital, Airport Road, Bangalore 560 017, India. s_pai@vsnl.com
authors.forename: Sanjay A
authors.initials: SA
authors.lastname: Pai
authors.forename: K N
authors.initials: KN
authors.lastname: Naresh
authors.forename: Poonam U
authors.initials: PU
authors.lastname: Patil
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018572:Disease-Free Survival; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000188:drug therapy