Nonalcoholic steatohepatitis with improved hepatic fibrosis after weight reduction.
A 65-year-old woman was admitted to our hospital for an investigation of liver dysfunction. She had mild obesity with hyperlipidemia, but no history of alcohol abuse. Other known causes of liver dysfunction, such as viruses, autoimmunity and drug effects, were excluded. The liver histology was consistent with nonalcoholic steatohepatitis (NASH). After diagnosis of NASH, the patient started diet and exercise therapy and, in parallel with weight reduction, her liver function improved. One year after the therapy, a liver biopsy showed that steatosis, necroinflammation and even fibrosis were improved. Hence, here we report a case of NASH in which weight reduction was effective in improving both biochemical and histological findings.
Fujikawa
Keita
K
First Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki.
Ohata
Kazuyuki
K
Honda
Takuya
T
Miyazoe
Seiji
S
Ichikawa
Tatsuki
T
Ishikawa
Hiroki
H
Hamasaki
Keisuke
K
Nakao
Kazuhiko
K
Toriyama
Kan
K
Eguchi
Katsumi
K
D000368:Aged; D001706:Biopsy; D005081:Exercise Therapy; D005234:Fatty Liver / Q000473:pathology / Q000628:therapy*; D005260:Female; D006505:Hepatitis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications*; D015431:Weight Loss