Attenuated ANF response to exercise in athletes with exercise-induced hypoxemia.
Some highly trained endurance athletes develop an exercise-induced hypoxemia (EIH) at least partially due to a hemodynamic factor with a potential stress failure on pulmonary capillaries. Atrial natriuretic factor (ANF) is a pulmonary vasodilatator and its release during exercise could be reduced with endurance training. We hypothesized that athletes exhibiting EIH, who have a greater training volume than non-EIH athletes, have a reduced ANF release during exercise explaining the pathophysiology of EIH. Ten highly trained EIH-athletes (HT-EIH), ten without EIH (HT-nEIH), and nine untrained (UT) males performed incremental exercise to exhaustion. No between group differences occurred in resting ANF plasma levels. In contrast to HT-nEIH and UT (p < 0.05), HT-EIH showed a smaller increase in ANF concentration between rest and maximal exercise (HT-EIH: 8.12 +/- 0.69 vs. 14.1 +/- 1.86 pmol x l (-1); HT-nEIH: 10.46 +/- 1 vs. 18.7 +/- 1.8 pmol x l (-1); UT: 6.23 +/- 0.95 vs. 20.38 +/- 2.79 pmol x l (-1)). During the recovery, ANF levels decreased significantly in HT-nEIH and UT groups (p < 0.05). Electrolyte values increased in all groups during exercise but were higher in both trained groups. In conclusion, this study suggested that ANF response to exercise may be important for exercise-induced hypoxemia.
Durand
F
F
Laboratoire Sport, Santé, Altitude, Département STAPS, Font-Romeu, France. fdurand@univ-perp.fr
Mucci
P
P
Hayot
M
M
Couret
I
I
Bonnardet
A
A
Préfaut
Ch
Ch
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000502:physiology*; D001798:Blood Proteins / Q000032:analysis; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology*; D008297:Male; D009994:Osmolar Concentration; D010807:Physical Endurance / Q000502:physiology*; D011188:Potassium / Q000097:blood; D012016:Reference Values; D012146:Rest / Q000502:physiology; D012964:Sodium / Q000097:blood
D001798:Blood Proteins; D009320:Atrial Natriuretic Factor; D012964:Sodium; D011188:Potassium