title: New piperidine scaffolds via nucleophilic reactivity of (-)-phenyloxazolopiperidine.
abstract: The present work illustrates the power of compound 2 as a chiral, nonracemic, and stable 2-piperideine (enamine) equivalent in the rapid and efficient construction of 3-substituted piperidines (carbon-carbon and carbon-sulfur bonds) such as 3-spiropiperidines. This methodology offers a new route to such systems that could compete with previously reported strategies.
authors.affiliation: Laboratoire de Pharmacognosie Associé au CNRS, UMR 8076 (BioCIS), Centre d'Etudes Pharmaceutiques, Université Paris-Sud 11, 5, Rue Jean-Baptiste Clément, 92296 Châtenay-Malabry CEDEX, France.
authors.forename: Erwan
authors.initials: E
authors.lastname: Poupon
authors.forename: David
authors.initials: D
authors.lastname: François
authors.forename: Nicole
authors.initials: N
authors.lastname: Kunesch
authors.forename: Henri-Philippe
authors.initials: HP
authors.lastname: Husson