Quantitative analysis of radiation-induced chromosome aberrations.
We review chromosome aberration modeling and its applications, especially to biodosimetry and to characterizing chromosome geometry. Standard results on aberration formation pathways, randomness, dose-response, proximity effects, transmissibility, kinetics, and relations to other radiobiological endpoints are summarized. We also outline recent work on graph-theoretical descriptions of aberrations, Monte-Carlo computer simulations of aberration spectra, software for quantifying aberration complexity, and systematic links of apparently incomplete with complete or truly incomplete aberrations.
Sachs
R K
RK
Department of Mathematics, University of California at Berkeley, Berkeley, CA 94720, USA. sachs@math.berkeley.edu
Levy
D
D
Hahnfeldt
P
P
Hlatky
L
L
D000818:Animals; D002455:Cell Division; D002869:Chromosome Aberrations; D019457:Chromosome Breakage; D002875:Chromosomes / Q000528:radiation effects* / Q000648:ultrastructure; D003198:Computer Simulation; D004247:DNA / Q000235:genetics; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008957:Models, Genetic; D009010:Monte Carlo Method
D004247:DNA