title: [Proteolytic enzymes and apoptosis].
abstract: Information about basic mechanisms of programmed cell death (apoptosis) development with participation of proteolytic enzymes is given in the review. The basic mechanisms of apoptosis launching are conditionally subdivided into three groups, depending on the "points of application" of apoptosis development initiating factor: membrane (receptor-dependent), mitochondrial and nuclear. Attention is accentuated on ubiquitin-dependent proteasomal proteolysis as the key system regulating apoptosis. The possible disturbances of apoptotic program realization are specified under various pathological processes and diseases.
authors.affiliation: Kolomiychenko Institute of Otolaryngology, Academy of Medical Sciences of Ukraine, Kyiv.
authors.forename: K N
authors.initials: KN
authors.lastname: Veremeenko
authors.forename: V E
authors.initials: VE
authors.lastname: Dosenko
authors.forename: V S
authors.initials: VS
authors.lastname: Nagibin
authors.forename: A I
authors.initials: AI
authors.lastname: Kizim
authors.forename: A A
authors.initials: AA
authors.lastname: Moĭbenko
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000494:pharmacology
chemical_list: D011480:Protease Inhibitors; D010447:Peptide Hydrolases