Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice.
The antiproliferative effect of serotonin-reuptake inhibitors (SSRI) and serotonin antagonists has been demonstrated in prostate tumors. Since Hypericum perforatum components act as serotonin-reuptake inhibitors and exert cytotoxic effects on several human cancer cell lines, in this work we analyzed the effect of a treatment with Hypericum perforatum extract (HPE) on the growth of human prostate cancer cells in vitro and in vivo. This study highlighted a significant reduction of tumor growth and number of metastasis suggesting that this natural compound may be useful in the treatment of prostate cancer.
Martarelli
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D
Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, ViaMarcello Scalzino 3, Camerino (MC) 62032, Italy. daniele.martarelli@unicam.it
Martarelli
B
B
Pediconi
D
D
Nabissi
M I
MI
Perfumi
M
M
Pompei
P
P
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D000432:Methanol / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D010936:Plant Extracts / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000517:prevention & control*; D014407:Tumor Cells, Cultured / Q000637:transplantation
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D000432:Methanol