Dissecting the functional role of different isoforms of the L-type Ca2+ channel.
There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced. However, it is also possible to insert specific mutations in a gene so that the pharmacological sensitivity of the gene product is altered. An example of such an approach shows how the abolition of the sensitivity of an L-type Ca(2+) channel isoform to dihydropyridines allows the investigation of the physiological role of these channels in different tissues.
Bourinet
Emmanuel
E
Département de Physiologie, Laboratoire de Génomique Fonctionnelle, Centre National de la Recherche Scientifique Unité Propre de Recherche 2580, Montpellier, France. Emmanuel.Bourinet@igh.cnrs.fr
Mangoni
Matteo E
ME
Nargeot
Joël
J
D000339:Affect / Q000502:physiology; D000818:Animals; D020746:Calcium Channels, L-Type / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D004095:Dihydropyridines / Q000494:pharmacology; D006321:Heart / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D051379:Mice; D008958:Models, Molecular; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000502:physiology
D020746:Calcium Channels, L-Type; D004095:Dihydropyridines; D007328:Insulin; D020033:Protein Isoforms