title: [Study of NMDAR expression in hippocampal CA(1) region in neonatal rats with hypoxic-ischemia].
abstract: OBJECTIVE
  To study the expressions of NMDAR in hippocampal CA(1) region after hypoxic-ischemic brain damage(HIBD) in neonatal rats.
  
  
  METHODS
  An neonatal rat model with hypoxic-ischemic brain damage was set up. The expression of NMDAR was detected in normal control and hypoxic-ischemic (HI) brain damage group by immunohistochemical staining and in situs hybridization.
  
  
  RESULTS
  The number of NR1(+) and NR1 mRNA(+) cells decreased slightly in hippocampal CA(1) region at 2 h after HI. The numbers increased from 24 h to 48 h after HI, and reached maximum at 72 h after HI.
  
  
  CONCLUSIONS
  NR1 expressed in hippocampal CA(1) region of normal neonatal rats, and the expression is up-regulated after HI brain injury.
authors.affiliation: Department of Pediatrics, Tangdu Hospital,Fourth Military Medical University, Xi'an 710038,China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Cao
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Cao
authors.forename: Bao-Xi
authors.initials: BX
authors.lastname: Wang
authors.forename: Sui-He
authors.initials: SH
authors.lastname: Yu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D056547:CA1 Region, Hippocampal / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate