[Basic researches on cell adhesion and its application in tendon tissue engineering].
Cell adhesion is a basic and very important tissue in the field of tissue engineering. Fibronectin and integrins are the most important elements to cell adhesion. Some surface receptors of fibroblast can also conjugate with type I collagen in extracellular matrix (ECM) directly. Laminin receptors on the surface of fibroblast bound to laminin also play a role in cell adhesion. In this paper are reviewed a number of related articles. The structures and function of fibronectin and integrins are discussed in detail; the tendon cell's adhesion structures are also discussed. Yet, there was scarcely any paper on the effects which the preservation of tissue engineered products may have on cells' adhesion fo ECM. Therefore, researching on cell adhesion and finding a way of preservation that has no or very little adverse effect on cell adhesion is an important topic. Results from expected advanced researches on cell adhesion may probably find promising applications in the field of tissue engineering.
Zhu
Xiaoqi
X
Insitute of Reparative and Reconstructive Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Qin
Tingwu
T
Yang
Zhiming
Z
D002448:Cell Adhesion; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D007797:Laminin / Q000378:metabolism; D013710:Tendons / Q000378:metabolism*; D023822:Tissue Engineering
D005353:Fibronectins; D016023:Integrins; D007797:Laminin