Neuropeptide chronomics in clinically healthy young adults: circaoctohoran and circadian patterns.
Endothelin-1 (ET-1) undergoes an about 8-h (circaoctohoran) rather than a circadian variation in clinical health. Herein, 24 h plasma concentrations of vasoactive intestinal peptide (VIP), substance P (SP), neuropeptide Y (NpY), and cortisol used as reference, were obtained from 20 healthy young adults starting at 07:00 or 19:00 h. Like ET-1, SP and NpY undergo a circaoctohoran variation, whereas VIP is circadian rhythmic, peaking during the night, some 8 h prior to the circadian acrophase of cortisol. Maps of circadian and extra-circadian patterns may serve for screening, diagnosis and a better understanding of mechanisms underlying the etiology of various diseases.
Löckinger
Alex
A
Department of Internal Medicine, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
Köberle
Dieter
D
König
Paul St
PS
Saria
Alois
A
Herold
Manfred
M
Cornélissen
Germaine
G
Halberg
Franz
F
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology; D003933:Diagnosis; D004194:Disease / Q000209:etiology; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D013373:Substance P / Q000097:blood*; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
D019332:Endothelin-1; D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D006854:Hydrocortisone