title: Sickle cell cerebrovascular disease: usual and unusual findings on MR imaging and MR angiography.
abstract: This paper demonstrates usual and unusual findings on MR imaging (MRI) including fluid-attenuated inversion recovery (FLAIR), diffusion- and perfusion-weighted image and MR angiography (MRA) in 30 patients with sickle cell cerebrovascular disease. This paper also illustrates the underlying pathophysiology of sickle cell cerebrovascular disease by using the cases with usual and unusual MR findings, including long-time follow-up cases during transfusion therapy. MRI and MRA are useful in defining the basis for stroke and assessing the effects of chronic transfusion therapy.
authors.affiliation: Department of Radiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA. moritani2001@yahoo.com
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
authors.forename: Yuji
authors.initials: Y
authors.lastname: Numaguchi
authors.forename: Norma B
authors.initials: NB
authors.lastname: Lemer
authors.forename: Martha K
authors.initials: MK
authors.lastname: Rozans
authors.forename: Avin E
authors.initials: AE
authors.lastname: Robinson
authors.forename: Akio
authors.initials: A
authors.lastname: Hiwatashi
authors.forename: Per-Lennart
authors.initials: PL
authors.lastname: Westesson
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology; D001803:Blood Transfusion; D002539:Cerebral Arterial Diseases / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement; D007223:Infant; D008137:Longitudinal Studies; D018810:Magnetic Resonance Angiography; D008297:Male; D009072:Moyamoya Disease / Q000175:diagnosis; D012640:Seizures / Q000175:diagnosis; D020521:Stroke / Q000175:diagnosis