title: Intravenous r-TPA in vertebrobasilar acute infarcts.
abstract: Presented are the clinical data of 18 consecutive patients who were treated by IV recombinant tissue plasminogen activator (r-TPA) for suspected vertebrobasilar (VB) acute ischemia within 7 hours. The mean delay for treatment was 5 +/- 3.6 hours. Mean baseline NIH Stroke Scale score was 17 +/- 4. At 3 months, 10 patients were independent (modified Rankin Scale [mRS] score = 0 to 2), whereas 8 patients showed a poor outcome (mRs = 3 to 6). IV r-TPA in VB ischemia in a 7-hour window may be safe and efficient.
authors.affiliation: Cerebrovascular Disease Center, CNRS, and Biostatistical Unit, HCL, France.
authors.forename: A
authors.initials: A
authors.lastname: Montavont
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: L
authors.initials: L
authors.lastname: Derex
authors.forename: M
authors.initials: M
authors.lastname: Hermier
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: F
authors.initials: F
authors.lastname: Philippeau
authors.forename: M
authors.initials: M
authors.lastname: Belo
authors.forename: F
authors.initials: F
authors.lastname: Turjman
authors.forename: P
authors.initials: P
authors.lastname: Adeleine
authors.forename: J C
authors.initials: JC
authors.lastname: Froment
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017762:Nadroparin / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012720:Severity of Illness Index; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D017762:Nadroparin; D010975:Platelet Aggregation Inhibitors; D011994:Recombinant Proteins; D006493:Heparin; D010959:Tissue Plasminogen Activator