Cutting edge: effector memory CD8+ T cells play a prominent role in recall responses to secondary viral infection in the lung.
The relative contributions of CD62L(high) (central) memory and CD62L(low) (effector) memory T cell populations to recall responses are poorly understood, especially in the respiratory tract. In this study, we took advantage of a dual-adoptive transfer system in the mouse to simultaneously follow the recall response of effector and central memory subpopulations to intranasal parainfluenza virus infection. Using MHC class I and class II multimers, we tracked the responses of Ag-specific CD8(+) and CD4(+) memory T cells in the same animals. The data show that effector memory T cells mounted recall responses that were equal to, or greater than, those mounted by central memory T cells. Moreover, effector memory T cells were more efficient at subsequently establishing a second generation of memory T cells. These data contrast with other studies indicating that central memory CD8(+) T cells are the prominent contributors to systemic virus infections.
Roberts
Alan D
AD
Trudeau Institute, Saranac Lake, NY 12983, USA.
Woodland
David L
DL
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018960:Hyaluronan Receptors / Q000032:analysis; D007156:Immunologic Memory; D019041:L-Selectin / Q000032:analysis; D008171:Lung Diseases / Q000276:immunology*; D008297:Male; D011939:Mental Recall; D051379:Mice; D008810:Mice, Inbred C57BL; D010253:Respirovirus Infections / Q000276:immunology*; D029082:Sendai virus
D018960:Hyaluronan Receptors; D019041:L-Selectin