More differences between HNPCC-related and sporadic carcinomas from the endometrium as compared to the colon.
OBJECTIVE
Recognition of hereditary nonpolyposis colorectal cancer (HNPCC)-related endometrial carcinoma from sporadic carcinoma by histologic features as compared with colonic cases.


METHODS
Case-control study.


METHODS
From the files of the Nijmegen Hereditary Cancer Clinic, HNPCC-related (n = 6) endometrial and colorectal (n = 18) carcinomas were selected. For every HNPCC-related tumor, 2 sporadic control cases were included. The tumors were evaluated for the following 7 pathologic features: tumor differentiation, T-stage, growth pattern, presence of Crohn-like lymphoid reaction, mucinous differentiation, presence of lymphangioinvasive growth, and the amount of tumor-infiltrating lymphocytes.


RESULTS
HNPCC-related endometrial carcinomas were significantly more often poorly differentiated (83% versus 27%), more often showed the presence of a Crohn-like lymphoid reaction (100% versus 13%) and lymphangioinvasive growth (67% versus 0%), and high number of tumor-infiltrating lymphocytes were more often present (100% versus 36%) compared with sporadic endometrial carcinomas. The differences between HNPCC and sporadic colorectal cancer specimens were less discriminating.


CONCLUSIONS
HNPCC-related endometrial carcinomas are characterized by poor differentiation, more frequent Crohn-like lymphoid reaction, lymphangioinvasive growth and more tumor-infiltrating lymphocytes. These features therefore might form the basis for selecting patients for counseling in a hereditary cancer clinic or testing for microsatellite instability or mutation analysis of mismatch repair genes, especially when they are of relatively young age.
van den Bos
Maartje
M
Departments of Pathology, Epidemiology and Human Genetics, University Medical Centre Nijmegen, The Netherlands.
van den Hoven
Mabel
M
Jongejan
Esther
E
van der Leij
Femke
F
Michels
Meta
M
Schakenraad
Sandra
S
Aben
Katja
K
Hoogerbrugge
Nicoline
N
Ligtenberg
Marjolijn
M
van Krieken
J Han
JH
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000473:pathology*; D003424:Crohn Disease / Q000473:pathology; D016889:Endometrial Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D042601:Lymphatic Vessels / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging