title: [Comparative studies on the resistance of hepatitis B by Syringa extract, IFN and ganyanling in HepG2.2.15 cells].
abstract: OBJECTIVE
  To explore the effects of Syringa extract, IFN and ganyanling on the the survival rate of HepG2.2.15 cells and the secretion of HBsAg and HBeAg by HepG2.2.15 cells.
  
  
  METHODS
  (3)H-TdR incorporation and ELISA were used to detect respectively the survival rate of HepG2.2.15 cells and levels of HBsAg and HBeAg in culture supernatant of HepG2.2.15 cells after stimulation with 3 drugs.
  
  
  RESULTS
  (1)All of the three drugs decreased the survival rate of HepG2.2.15 cells to the various extent with the increase of doses. The effect of the Syringa extract was between those of IFN and ganyanling. (2)All of the three drugs might suppress the secration of HBsAg and HbeAg by HepG2.2.15 cells in dose-dependent manner, while the the effect of the syringa extract was between those of IFN and ganyanling.
  
  
  CONCLUSIONS
  The Syringa extract is an effective and low toxic anti-hepatitis B drug.
authors.affiliation: Department of Gastroenterology, Affiliated Hospital, Jilin Military Medical College, Fourth Military Medical University,Jilin 132013, China.
authors.forename: Shi-Qig
authors.initials: SQ
authors.lastname: Gao
authors.forename: Jun-Qi
authors.initials: JQ
authors.lastname: Niu
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Liu
authors.forename: Zhen-Xun
authors.initials: ZX
authors.lastname: Jin
authors.forename: Yi-Ling
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000998:Antiviral Agents; D006509:Hepatitis B; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D031662:Syringa
chemical_list: D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens