Adverse reactions to accidental forearm injection of Bacille Calmette-Guerin vaccine in schoolchildren: 12-month cohort follow-up.
This study examined the natural history of reaction after accidental intradermal administration of bacille Calmette-Guerin (BCG) vaccine instead of purified protein derivative (PPD) in 226 schoolchildren. At 18 days after vaccination, a local reaction with a diameter of 4.5-14 mm was found in 62% of the students, and ulceration with discharge was found in 26.6%; corresponding rates at 120 days were 72.3% and 38% and at 281 days were 73% and 6%. At 345 days, 85% of the students had a dry scar measuring 5-14 mm in diameter, and none had ulceration or discharge.
Gross
Samuel
S
Ministry of Health, Hasharon District, Israel.
Kahan
Ernesto
E
Vesterman
Liora
L
Havkin
Ofra
O
Leventhal
Alex
A
D001500:BCG Vaccine / Q000009:adverse effects*; D002648:Child; D005542:Forearm / Q000473:pathology*; D006801:Humans; D015994:Incidence; D007279:Injections, Subcutaneous; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012882:Skin Tests
D001500:BCG Vaccine