title: Sedation in children undergoing CT scan or MRI: effect of time-course and tolerance of rectal chloral hydrate.
abstract: The aim of this paper was to describe the time-course of the sedative effect of rectal chloral hydrate (75 mg/kg) in children undergoing CT scan or MRI. Twenty children (2.13 +/- 1.43 years old) were administered 75 mg/kg chloral hydrate rectally (chloralhydrat-rectiole rectal formulation, Dr Mann-Pharma Lab, Berlin, Germany), before a CT scan or an NMR imaging. Sedation was measured at specific times using a sedation score of 1-6. Patients were continuously monitored for respiratory and heart rate, systolic and diastolic blood pressures, and oxygen saturation. About 82.35 and 94.11% of the patients had a score of sedation > or = 3 within 15 and 30 min, respectively. The mean time to effective sedation (score > or = 3) was of 0.30 +/- 0.14 h (median time, 0.25 h). The mean duration of effective sedation (score > or = 3) was 1.29 +/- 1.05 h (median duration, 0.75 h). A total of 93.1% of the X-ray sections were obtained without artifact and sedation was considered by radiologists to be efficient for 83.3% of the procedures. This sedation procedure appeared efficient and safe during ambulatory CT scan and NMR imaging. The long-term effect of chloral hydrate, however, remains to be evaluated.
authors.affiliation: Pharmacologie Périnatale et Pédiatrique, Université René Descartes, Hôpital Cochin--Saint Vincent de Paul, 82 avenue Denfert Rochereau, 75674 Paris 14, France. jm.treluyer@svp.ap-hop-paris.fr
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Treluyer
authors.forename: Christine
authors.initials: C
authors.lastname: Andre
authors.forename: Pierre-François Ceccaldi
authors.initials: PF
authors.lastname: Carp
authors.forename: Martin
authors.initials: M
authors.lastname: Chalumeau
authors.forename: Sylvie
authors.initials: S
authors.lastname: Tonnelier
authors.forename: Cédric
authors.initials: C
authors.lastname: Cuq
authors.forename: Gabriel
authors.initials: G
authors.lastname: Kalifa
authors.forename: Gérard
authors.initials: G
authors.lastname: Pons
authors.forename: Catherine
authors.initials: C
authors.lastname: Adamsbaum
mesh_terms: D000285:Administration, Rectal; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate