[The role of leukocytes in microcirculation dynamics in the norm and pathology].
The physiological functions grow to be more perfect and complicated in the process of evolution. However, a developing function could display some evidence of regress and, in certain cases, it can trigger serious diseases including autoimmune ones. Conventionally, we refer to the above cases as to "errors" of evolution. The present case study deals with a negative factor of leukocytes in the cerebral microcirculation. Leukocytes were shown, experimentally, to inhibit the capillary blood flow owing to their big volume (2-2.5-fold more versus that of erythrocytes). An increasing trend to adhesion due to hypoxia is responsible for shaping of leukocytes' conglomerates, which cause the occlusion of venules and of the smallest cerebral veins. It entails the effect known as "no re-flow" resulting in death.
Ivanov
K P
KP
Mel'nikova
N N
NN
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D004727:Endothelium / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D002534:Hypoxia, Brain / Q000378:metabolism / Q000473:pathology; D007962:Leukocytes / Q000502:physiology*; D008833:Microcirculation / Q000502:physiology; D051381:Rats
D015815:Cell Adhesion Molecules