title: The effects of admission alcohol level on cerebral blood flow and outcomes after severe traumatic brain injury.
abstract: This study examined the relationship between admission serum alcohol level (ETOH) and cerebral blood flow (CBF) and outcomes in the adult traumatic brain injured (TBI) population. We hypothesized that individuals with ETOH > 100 mg/dL will have decreased blood flow on admission and poorer outcomes. Eighty subjects, age 16-65, with severe TBI (Glasgow Coma Score [GCS] </= 8) were entered into the study. Correlational analysis assessed the relationship between ETOH and admission severity of injury scores as measured by Marshall and APACHE III scores, CBF, and outcomes. Comparison of CBF and outcomes between groups based on admission serum ETOH level was conducted with analysis of variance and post hoc Scheffé analyses as well as regression analysis. There was a significant relationship between serum ETOH level and GCS (p = 0.02), but not APACHE III scores (p = 0.12) or Marshall scores (p = 0.27). There was a significant correlation between global CBF and serum ETOH level (p = 0.02). There was no statistically significant association between serum ETOH level and GOS at 3 (p = 0.97), 6 (p= 0.56), or 12 (p = 0.73) months after injury. The data indicated that serum ETOH levels > 100 mg/dL at the time of admission after a TBI were associated with a decrease in global CBF. Elevated serum ETOH level at time of injury did not, however, impact outcomes.
authors.affiliation: Acute and Tertiary Care, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania 15261, USA. salexand@pitt.edu
authors.forename: Sheila
authors.initials: S
authors.lastname: Alexander
authors.forename: Mary E
authors.initials: ME
authors.lastname: Kerr
authors.forename: Howard
authors.initials: H
authors.lastname: Yonas
authors.forename: Donald W
authors.initials: DW
authors.lastname: Marion
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000097:blood / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D000431:Ethanol / Q000097:blood* / Q000494:pharmacology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D020127:Recovery of Function / Q000187:drug effects*
chemical_list: D000431:Ethanol