title: Trends in the management of severe acute pancreatitis: interventions and outcome.
abstract: BACKGROUND
  Severe acute pancreatitis (SAP) in the intensive care unit (ICU) is a complex and challenging problem. The aim of the present study was to identify trends in management of SAP patients admitted to a tertiary level ICU, and to relate these to changes in interventions and outcome.
  
  
  METHODS
  Patients admitted to the Department of Critical Care Medicine (DCCM), Auckland Public Hospital with SAP from 1988 to 2001 (inclusive) were identified from the DCCM prospective database, and data were extracted from several sources.
  
  
  RESULTS
  One hundred and twelve patients (men 69, women 43, mean age (+/-SD) 57.3 years +/- 14.3) were admitted with SAP to DCCM in the 13-year period. Aetiology was gallstones (42%), alcohol (29%), or idiopathic (29%). At admission to DCCM the median duration of symptoms was 7 days (range 1-100) and the mean (+/-SD) Acute Physiology and Chronic Health Evaluation II score was 19.9 +/- 8.2. Ninety-nine patients (88%) had respiratory failure and 79 (71%) had circulatory failure. The number of necrosectomies peaked between 1991 and 1995 (17/35 patients (49%) compared to 4/22 (18%) prior 1991; chi(2) = 6.90, P = 0.032). Abdominal decompression, enteral nutrition, percutaneous tracheostomy, and the use of stents in endoscopic retrograde cholangiopancreatography were introduced over the study period. The length of stay in DCCM did not alter (median 4 days, range 1-60) but there was a reduction in the length of hospital stay (median 36 days to 15 days; anova= 6.16, P = 0.046). The overall mortality was 31% (35/112) and did not alter over the study period.
  
  
  CONCLUSIONS
  SAP remains a formidable disease with a high mortality despite a number of changes in intensive care and surgical management.
authors.affiliation: Hepato-Biliary Pancreatic/Upper Gastrointestinal Unit, Department of General Surgery, Auckland Hospital, Auckland, New Zealand.
authors.forename: Richard
authors.initials: R
authors.lastname: Flint
authors.forename: John
authors.initials: J
authors.lastname: Windsor
authors.forename: Martin
authors.initials: M
authors.lastname: Bonham
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003422:Critical Care / Q000639:trends*; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D010195:Pancreatitis / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome