Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions.
mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
Hazan
Ronen
R
Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Sat
Boaz
B
Engelberg-Kulka
Hanna
H
D016923:Cell Death; D004268:DNA-Binding Proteins / Q000502:physiology*; D004722:Endoribonucleases; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*; D006358:Hot Temperature; D018384:Oxidative Stress
D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C422954:MazE protein, E coli; C422955:MazF protein, E coli; D004722:Endoribonucleases