title: Detectable serum PSA after radical prostatectomy. Clinical and pathological relevance of perianastomotic biopsies.
abstract: BACKGROUND
  Few reports have detailed the histopathological results of biopsies of the vesicourethral anastomosis or prostatic bed in patients with a detectable postoperative PSA.
  
  
  METHODS
  Among a series of 153 patients who underwent radical retropubic prostatectomies, we analyzed the results of 64 perianastomotic biopsies performed in 17 men with a detectable PSA and no evidence of local recurrence or distant metastases.
  
  
  RESULTS
  Fourteen of the 17 patients had a relapse of prostatic carcinoma; the results of histology in the three pT2bN0M0 patients revealed the presence of benign prostatic hyperplasia in 2 patients and atypical cribriform proliferation in 1 patient. The first two patients are free from prostatic cancer recurrence 36 months after perianastomotic biopsies; a further biopsy performed 6 months after in the third patient showed the presence of prostatic carcinoma.
  
  
  CONCLUSIONS
  The present study raises the possibility that residual benign tissue, resulting from unintentional disruption of the prostatic capsule during surgery, may be responsible for a detectable postoperative PSA. These cases comprise a histopathological classification described as "intraprostatic surgical margin".
authors.affiliation: Institute of Urology, Università Politecnica delle Marche Medical School, Ancona, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Minardi
authors.forename: A B
authors.initials: AB
authors.lastname: Galosi
authors.forename: L
authors.initials: L
authors.lastname: Dell'Atti
authors.forename: M
authors.initials: M
authors.lastname: Yehia
authors.forename: G
authors.initials: G
authors.lastname: Muzzonigro
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000473:pathology; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery
chemical_list: D017430:Prostate-Specific Antigen