Organelle identity and the organization of membrane traffic.
Generating and maintaining features that distinguish one organelle from another is essential for accurate membrane traffic. Recent work has revealed that organelles express 'identity' by the local generation of activated GTP-binding proteins and lipid species. These recruiting determinants are then recognized by cytosolic proteins that facilitate the formation and delivery of vesicles at the correct compartment.
Munro
Sean
S
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. sean@mrc-lmb.cam.ac.uk
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism* / Q000648:ultrastructure; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D015388:Organelles / Q000378:metabolism* / Q000648:ultrastructure; D021381:Protein Transport / Q000502:physiology; D022161:Transport Vesicles / Q000378:metabolism / Q000648:ultrastructure
D008563:Membrane Lipids; D008565:Membrane Proteins; D019204:GTP-Binding Proteins