Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock.
The organs of the hepatosplanchnic system are considered to play a key role in the development of multiorgan failure during septic shock. Impaired oxygenation of the intestinal mucosa can lead to disruption of the intestinal barrier, which may promote a vicious cycle of inflammatory response, increased oxygen demand and inadequate oxygen supply. Standard septic shock therapy includes supportive treatment such as fluid resuscitation, administration of vasopressors (adrenergic and nonadrenergic drugs), and respiratory and renal support. These therapies may have beneficial or detrimental effects not only on systemic haemodynamics but also on splanchnic haemodynamics, at both the macrocirculatory and microcirculatory levels. This clinical review focuses on the splanchnic haemodynamic and metabolic effects of standard therapies used in patients with septic shock, as well as on the recently described nonconventional therapies such as vasopressin, prostacyclin and N-acetyl cysteine.
Asfar
Pierre
P
Département de Réanimation Médicale, Centre Hospitalier Universitaire, Angers, France.
De Backer
Daniel
D
Meier-Hellmann
Andreas
A
Radermacher
Peter
P
Sakka
Samir G
SG
D000111:Acetylcysteine / Q000627:therapeutic use; D005440:Fluid Therapy; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply*; D008099:Liver / Q000098:blood supply*; D009102:Multiple Organ Failure / Q000503:physiopathology / Q000517:prevention & control; D010100:Oxygen / Q000097:blood; D012121:Respiration, Artificial; D012772:Shock, Septic / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D013152:Splanchnic Circulation / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D014662:Vasoconstrictor Agents; D010100:Oxygen; D000111:Acetylcysteine