Analysis of polymorphisms at the tumor suppressor gene p53 (TP53) in contributing to the risk for schizophrenia and its associated neurocognitive deficits.
Owing to the role of the nuclear phosphoprotein p53 in the regulation of neurodegeneration and neurodevelopmental processes, some authors have suggested TP53 as a candidate gene for schizophrenia and/or the neurocognitive deficits commonly observed in these patients. In the present study we have analyzed two polymorphisms (Pro72Arg and 16 bp insertion) located on the TP53 gene in order to investigate their role in the risk of developing schizophrenia and their effect on the neurocognitive profile of these patients in the context of an association study. The distribution of genotypes, alleles and haplotypes did not differ between cases and controls. Additionally, we did not detect any influence of this genetic variability in the neurocognitive functions of schizophrenic patients. Our findings suggest that the analyzed variability of the TP53 gene does not influence (i) the risk of suffering from schizophrenia and (ii) the deficits in the neurocognitive profile of these patients.
Papiol
Sergi
S
Unitat d'Antropologia, Departament Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain. sergi.papiol@ub.edu
Arias
Bárbara
B
Barrantes-Vidal
Neus
N
Guitart
Marc
M
Salgado
Purificación
P
Catalán
Rosa
R
Fañanás
Lourdes
L
D000328:Adult; D000483:Alleles; D001120:Arginine / Q000235:genetics; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000209:etiology / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011392:Proline / Q000235:genetics; D012306:Risk; D012559:Schizophrenia / Q000150:complications / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D004251:DNA Transposable Elements; D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011392:Proline