Eki2 is upregulated specifically in the testis during mouse sex determination.
We have identified a gene with gonad restricted expression throughout mouse development, which is orthologous to human EKI2 (ethanolamine kinase 2). Our studies showed that mouse Eki2 expression became upregulated in the male gonad during the period of sex determination. Expression was restricted to the Sertoli cells of the developing testis. Eki2 has sequence similarity to ethanolamine (73%) and choline kinases (54%).
Hurley
Tanya M
TM
Murdoch Children's Research Institute, Centre for Hormone Research, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Vic 3052, Australia.
McClive
Peter J
PJ
Sarraj
Mai A
MA
Sinclair
Andrew H
AH
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D013737:Testis / Q000196:embryology / Q000378:metabolism*; D015854:Up-Regulation
D017853:Phosphotransferases (Alcohol Group Acceptor); C020125:ethanolamine kinase