Complexes of dichloro[2-(dimethylaminomethyl)phenyl-C1,N]gold(III), [Au(damp-C1,N)Cl2], with formylferrocene thiosemicarbazones: synthesis, structure and cytotoxicity.
Dichloro[2-(dimethylaminomethyl)phenyl- phenyl-C1,N]gold(III), [Au(damp-C1,N)Cl2], reacts with the formylferrocene thiosemicarbazones derived from 4-methyl-, 4-phenyl-, 4-ethyl- and 4,4-dimethyl-3-thiosemicarbazides, HFcTSC, to give complexes of general formula [Au(Hdamp-1C)Cl(FcTSC)]Cl. These complexes were isolated and characterized by elemental analysis, mass spectrometry and IR, 1H NMR and (13)C NMR spectroscopy. In some cases, cyclic voltammetric studies were carried out and these showed that the complexation of gold affects the redox behaviour of the ferrocene unit. The in vitro antitumor activity against the HeLa cell line was also determined for the more soluble complexes. The IC(50) values were found to be higher than that of cisplatin but the maximum antiproliferative activity was similar.
Casas
José S
JS
Departamento de Química Inorgánica, Facultade de Quimica, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Galicia, Spain.
Castaño
María V
MV
Cifuentes
María C
MC
García-Monteagudo
Juán C
JC
Sánchez
Agustín
A
Sordo
José
J
Abram
Ulrich
U
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D002945:Cisplatin / Q000633:toxicity; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D017612:Gold Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006367:HeLa Cells; D006801:Humans; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
D000970:Antineoplastic Agents; D005290:Ferric Compounds; D017612:Gold Compounds; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D002945:Cisplatin