[An experimental study of the therapeutic effect of interleukin-2 and interleukin-12 with and without amphotericin B on pulmonary fungal infection].
OBJECTIVE
To study the therapeutic effect of interleukin-2 (IL-2) and interleukin-12 (IL-12) with and without amphotericin B on pulmonary fungal infection of mice.


METHODS
A mouse model of pulmonary invasive aspergillus fumigatus (IPA) infection was established and the mice were divided into different groups, treated with IL-2 and IL-12 with and without amphotericin B. The survival number of mice in 15 days and the colony count of lung tissue in the different groups were observed.


RESULTS
IL-2, IL-12 and amphotericin B showed synergistic effect in prolonging the survival of the infected mice and reducing the colony count in the lung tissue.


CONCLUSIONS
IL-2 and IL-12 are effective adjuvant therapeutic agents in the immunosuppressed hosts.
Zhang
Chang-ran
CR
Department of Internal Medicine, Huang Pu Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.
Tang
Ying-chun
YC
Kawakami
K
K
Zhang
Tian-tuo
TT
Zhang
Kou-xing
KX
Zhu
Jia-xin
JX
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D015169:Colony Count, Microbial; D004357:Drug Synergism; D018664:Interleukin-12 / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation
D000935:Antifungal Agents; D007376:Interleukin-2; D018664:Interleukin-12; D000666:Amphotericin B