title: Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia.
abstract: We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukaemia (AML)-M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4-CBP and CBP-MYST4 chimaeric transcripts were products of in-frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively. The potential resulting chimaeric proteins showed similarities with MYST3-CBP, MYST3-P300 and MYST3-NCOA2 putative fusion proteins found in other cases of AML.
authors.affiliation: Département d'Oncologie Moléculaire, Institut Paoli-Calmettes and JMR 599 Inserm, Marseille, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Murati
authors.forename: José
authors.initials: J
authors.lastname: Adélaïde
authors.forename: Marie-Joëlle
authors.initials: MJ
authors.lastname: Mozziconacci
authors.forename: Cornel
authors.initials: C
authors.lastname: Popovici
authors.forename: Nadine
authors.initials: N
authors.lastname: Carbuccia
authors.forename: Anne
authors.initials: A
authors.lastname: Letessier
authors.forename: Françoise
authors.initials: F
authors.lastname: Birg
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
authors.forename: Max
authors.initials: M
authors.lastname: Chaffanet
mesh_terms: D000208:Acute Disease; D019677:Artificial Gene Fusion; D002678:Chimera / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*