title: Decreased total nitric oxide production in patients with duchenne muscular dystrophy.
abstract: Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r = -0.384, p = 0.0391) in the DMD group. Disruption of NO systems may contribute to the development of muscular dystrophy and have implications for therapeutic strategies.
authors.affiliation: Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. tkasai@m.kufm.kagoshima-u.ac.jp
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kasai
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Abeyama
authors.forename: Teruto
authors.initials: T
authors.lastname: Hashiguchi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Fukunaga
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015536:Down-Regulation; D004452:Echocardiography; D006801:Humans; D008875:Middle Aged; D020388:Muscular Dystrophy, Duchenne / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D010084:Oxidation-Reduction; D013318:Stroke Volume
chemical_list: D009569:Nitric Oxide