title: Risk from inhaled mycotoxins in indoor office and residential environments.
abstract: Mycotoxins are known to produce veterinary and human diseases when consumed with contaminated foods. Mycotoxins have also been proposed to cause adverse human health effects after inhalation exposure to mold in indoor residential, school, and office environments. Epidemiologic evidence has been inadequate to establish a causal relationship between indoor mold and nonallergic, toxigenic health effects. In this article, the authors model a maximum possible dose of mycotoxins that could be inhaled in 24 h of continuous exposure to a high concentration of mold spores containing the maximum reported concentration of aflatoxins B1 and B2, satratoxins G and H, fumitremorgens B and C, verruculogen, and trichoverrols A and B. These calculated doses are compared to effects data for the same mycotoxins. None of the maximum doses modeled were sufficiently high to cause any adverse effect. The model illustrates the inefficiency of delivery of mycotoxins via inhalation of mold spores, and suggests that the lack of association between mold exposure and mycotoxicoses in indoor environments is due to a requirement for extremely high airborne spore levels and extended periods of exposure to elicit a response. This model is further evidence that human mycotoxicoses are implausible following inhalation exposure to mycotoxins in mold-contaminated home, school, or office environments.
authors.affiliation: GlobalTox, Inc., Redmond, Washington, USA. BKelman@GlobalTox.Com
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Kelman
authors.forename: Coreen A
authors.initials: CA
authors.lastname: Robbins
authors.forename: Lonie J
authors.initials: LJ
authors.lastname: Swenson
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Hardin
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects / Q000032:analysis* / Q000706:statistics & numerical data; D000465:Algorithms; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects / Q000032:analysis* / Q000706:statistics & numerical data; D008297:Male; D015233:Models, Statistical; D009183:Mycotoxins / Q000009:adverse effects / Q000032:analysis*; D018570:Risk Assessment; D013172:Spores, Fungal / Q000737:chemistry
chemical_list: D009183:Mycotoxins