title: Molecular design based on 3D pharmacophores. Applications to 5-HT7 receptors.
abstract: A definition of a pharmacophore for the 5-HT7 antagonists was carried out by searching the common chemical features of selective antagonists from the literature. A molecular design is described by analyzing the differences between this new pharmacophore and three other 3D serotonin pharmacophores previously described. This comparison led to the synthesis of a new series of potent 5-HT7 antagonists.
authors.affiliation: Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, 5 rue Vaubénard, 14032 Caen, France.
authors.forename: Alban
authors.initials: A
authors.lastname: Lepailleur
authors.forename: Ronan
authors.initials: R
authors.lastname: Bureau
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lemaître
authors.forename: François
authors.initials: F
authors.lastname: Dauphin
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lancelot
authors.forename: Vincent
authors.initials: V
authors.lastname: Contesse
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lenglet
authors.forename: Catherine
authors.initials: C
authors.lastname: Delarue
authors.forename: Hubert
authors.initials: H
authors.lastname: Vaudry
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D008958:Models, Molecular; D011487:Protein Conformation; D011985:Receptors, Serotonin / Q000737:chemistry*
chemical_list: D011985:Receptors, Serotonin; C104425:serotonin 7 receptor