title: Interaction of mitochondrial voltage-dependent anion channel from rat brain with plasminogen protein leads to partial closure of the channel.
abstract: Voltage-dependent anion channel (VDAC) is reported to be the receptor for plasminogen kringle5. In this paper, the interaction of VDAC from rat brain mitochondria with plasminogen protein has been investigated through bilayer electrophysiological studies. We report for the first time that interaction of plasminogen with VDAC leads to partial closure of the channel on a lipid bilayer. This could be a mechanism of modulation of VDAC gating in a cellular system.
authors.affiliation: Department of Biophysics, University of Delhi South Campus, Benito Jaurez Road, New Delhi 110021, India.
authors.forename: Jyotirmoy
authors.initials: J
authors.lastname: Banerjee
authors.forename: Subhendu
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004553:Electric Conductivity; D006801:Humans; D007473:Ion Channels / Q000378:metabolism* / Q000502:physiology; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism*; D010958:Plasminogen / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D018272:Porins / Q000378:metabolism* / Q000502:physiology; D051381:Rats; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D050994:Voltage-Dependent Anion Channels
chemical_list: D007473:Ion Channels; D008051:Lipid Bilayers; D018272:Porins; D011994:Recombinant Proteins; D050994:Voltage-Dependent Anion Channels; D010958:Plasminogen