title: [Identification and management of hereditary predisposition to cancer of the breast and the ovary (update 2004)].
abstract: BACKGROUND
  Since the last recommendations, up to 2,500 new references had been published on that topic.
  
  
  METHODS
  On the behalf of the health Minister, the Ad Hoc Committee consisted of 13 experts carried out a first version revisited by five additional experts who critically analyzed the first version of the report.
  
  
  METHODS
  Breast and ovarian cancer seem to be associated with fewer deleterious mutation of BRCA12 and BRCA2 than previously thought. The screening of ovarian cancer is still not an attractive option while in contrast MRI may be soon for these young women with dense breast, the recommended option for breast cancer screening. The effectiveness of prophylactic surgeries is now well established. French position is to favor such surgeries with regard to a quality of life in line with the expected benefit, and providing precise and standardized process described in the recommendation.
  
  
  CONCLUSIONS
  Due to methodological flaws, the low power and a short follow-up of the surveys, this statement cannot however aspire to a high stability.
authors.affiliation: Médecin Interniste Département d'Oncogénétique, Institut Paoli-Calmettes, Inserm E9939, Marseille. eisinger@marseille.inserm.fr
authors.forename: François
authors.initials: F
authors.lastname: Eisinger
authors.forename: Brigitte
authors.initials: B
authors.lastname: Bressac
authors.forename: Damienne
authors.initials: D
authors.lastname: Castaigne
authors.forename: Pierre-Henri
authors.initials: PH
authors.lastname: Cottu
authors.forename: Jacques
authors.initials: J
authors.lastname: Lansac
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lefranc
authors.forename: Anne
authors.initials: A
authors.lastname: Lesur
authors.forename: Catherine
authors.initials: C
authors.lastname: Noguès
authors.forename: Janine
authors.initials: J
authors.lastname: Pierret
authors.forename: Séverine
authors.initials: S
authors.lastname: Puy-Pernias
authors.forename: Hagay
authors.initials: H
authors.lastname: Sobol
authors.forename: Anne
authors.initials: A
authors.lastname: Tardivon
authors.forename: Henri
authors.initials: H
authors.lastname: Tristant
authors.forename: Richard
authors.initials: R
authors.lastname: Villet
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D005602:France; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008408:Mastectomy / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D010052:Ovariectomy; D012306:Risk