title: Use of immunohistochemical marker calretinin in the diagnosis of a diffuse malignant metastatic mesothelioma in an equine.
abstract: Mesotheliomas are rarely reported in animal species. In this report, the occurrence of a diffuse, metastatic mesothelioma in a 6-year-old gray Arabian mare is described. The mare was presented on clinical examination with ascites, bilateral pleural effusion, and pleural roughening. Necropsy revealed abundant fluid in the abdominal and thoracic cavities. The surface of all organs was thick and fibrosed with multiple raised nodules and hemorrhages. Histology was characteristic of a generalized, biphasic mesothelioma with vascular and lymph nodes metastases. It is believed that the primary tumor developed in the pericardium and spread through lymphatics. In this report, calretinin was used as an immunohistochemical marker in the diagnosis of mesothelioma in an equine species for the first time.
authors.affiliation: Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4467, USA.
authors.forename: G
authors.initials: G
authors.lastname: Stoica
authors.forename: N
authors.initials: N
authors.lastname: Cohen
authors.forename: O
authors.initials: O
authors.lastname: Mendes
authors.forename: Hun-Taek
authors.initials: HT
authors.lastname: Kim
mesh_terms: D000818:Animals; D064032:Calbindin 2; D017809:Fatal Outcome; D005260:Female; D006734:Horse Diseases / Q000378:metabolism* / Q000473:pathology; D006736:Horses; D007150:Immunohistochemistry / Q000379:methods / Q000662:veterinary; D008654:Mesothelioma / Q000378:metabolism / Q000662:veterinary*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*; D013899:Thoracic Neoplasms / Q000473:pathology / Q000662:veterinary*
chemical_list: D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G