["STRESSEN" in the treatment of psycho-physical stress and hyperhomocysteinemia in patients with migraine without aura].
OBJECTIVE
A previous clinical trial evidenced, in patients affected by migraine without aura, that treatment with medicinal product STRESSEN determined a reduction of homocysteinemia and an improved general state of health, also if the protocol had not provided for the latter evaluation. The aim of this study is to confirm, in a similar population, the efficacy of STRESSEN on hyperhomocysteinemia and to control the psycho-physical state of the patients by means of specific parameters.


METHODS
20 hyperhomocysteinemic (> 15 micromol/ 1) patients suffering from psycho-physical stress and migraine without aura were enrolled. The efficacy of a 30 days treatment with STRESSEN was evaluated through dosage of this amino acid and through a questionnaire on the general state of health.


RESULTS
Homocysteinemia was reduced of 52.1% (P < 0.001) and the score representing the general state of health decreased from 1.63 +/- 0.38 to 0.78 +/- 0.12 (P < 0.001).


CONCLUSIONS
This study supported the effectiveness of STRESSEN treatment to restore physiological profile of homocysteinemia and to improve the psycho-physical conditions, usually altered by stress for which the drug is already indicated.
Di Sabato
F
F
Dipartimento di Medicina Clinica, Centro Cura delle Cefalee, Policlinico Umberto I, Roma, Italia. francesco.disabato@uniroma1.it
D000328:Adult; D000368:Aged; D004338:Drug Combinations; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D020326:Migraine without Aura / Q000150:complications / Q000188:drug therapy*; D013312:Stress, Physiological / Q000150:complications / Q000188:drug therapy*; D013315:Stress, Psychological / Q000150:complications / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D014805:Vitamin B 12 / Q000008:administration & dosage
D004338:Drug Combinations; D005492:Folic Acid; D014805:Vitamin B 12