Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system.
This consensus report gives a detailed description of the use of somatostatin analogs in the management of neuroendocrine tumors of the gastroenteropancreatic system. As background information we have outlined critical aspects of the pathology, the use of tumor markers, a definition of functional and non-functional digestive neuroendocrine tumors, different imaging modalities, surgical considerations, liver embolization and the use of cytotoxic drugs as well as interferon. Included in the report is an overview of somatostatin, somatostatin analogs and its receptor expression in different neuroendocrine tumors. It will also define the binding affinities of different somatostatin analogs to the five different subtypes of somatostatin receptor. We compare the efficacy of octreotide and lanreotide in reducing diarrhea and flushing. Side-effects are described and we provide practical information on somatostatin analog treatment.
Oberg
K
K
Department of Endocrine Oncology, University Hospital, Uppsala, Sweden. kjell.oberg@medsci.uu.se
Kvols
L
L
Caplin
M
M
Delle Fave
G
G
de Herder
W
W
Rindi
G
G
Ruszniewski
P
P
Woltering
E A
EA
Wiedenmann
B
B
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004067:Digestive System Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D013505:Digestive System Surgical Procedures / Q000379:methods; D006801:Humans; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000628:therapy; D015282:Octreotide / Q000627:therapeutic use*; D017481:Receptors, Somatostatin / Q000378:metabolism; D013004:Somatostatin / Q000031:analogs & derivatives / Q000378:metabolism / Q000627:therapeutic use*
D018931:Antineoplastic Agents, Hormonal; D017481:Receptors, Somatostatin; D013004:Somatostatin; D015282:Octreotide