title: Marked thrombocytosis in a child with advanced myelodysplastic syndrome.
abstract: Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis with rare occurrence in childhood. Conversely to adult affected patients, refractory anemia with ringed sideroblasts and the 5q-syndrome, which are associated with thrombocytosis are virtually absent in the pediatric age group. We describe the case of an 1-year-old boy with advanced MDS, specifically refractory anemia with excess of blasts who presented with leukocytopenia and anemia but marked thrombocytosis at diagnosis. Thrombocytosis resolved without therapy. This case illustrates the relationship between MDS and myeloproliferative disorders.
authors.affiliation: Department of Pediatrics, University of Kiel, Schwanenweg 20, 24105 Kiel, Germany. a.claviez@pediatrics.uni-kiel.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Claviez
authors.forename: Bona
authors.initials: B
authors.lastname: Ngoumou
authors.forename: Lana
authors.initials: L
authors.lastname: Harder
authors.forename: Irith
authors.initials: I
authors.lastname: Baumann
authors.forename: Charlotte
authors.initials: C
authors.lastname: Niemeyer
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002648:Child; D020732:Cytogenetic Analysis; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods; D012074:Remission Induction; D013922:Thrombocytosis / Q000209:etiology* / Q000628:therapy; D018183:Transplantation Chimera; D014184:Transplantation, Homologous