In vitro assays for evaluation of drug activity against Leishmania spp.
Leishmania is a parasitic protozoan which causes severe disease in humans and dogs. Screening of new compounds against leishmaniasis is particularly needed to determine the toxicity of some existing drugs and the appearance of drug-resistant strains. Reliable and simple in vitro models are required for large-scale initial screenings. In this review different methods for in vitro evaluation of drug activity against Leishmania spp. are summarized.
Fumarola
Luciana
L
Department of Internal Medicine, Immunology and Infectious Diseases, Microbiology and Immunology Section, University of Bari, Medical School, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. lfumarola@midim.uniba.it
Spinelli
Rosa
R
Brandonisio
Olga
O
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D007891:Leishmania / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests
D000981:Antiprotozoal Agents