title: Building addressable libraries: the use of electrochemistry for generating reactive Pd(II) reagents at preselected sites on a chip.
abstract: A Pd(II) reagent has been generated at preselected sites on an electrochemically addressable chip. The reagent was used to effect the Wacker oxidation of an olefin substrate bound to the chip near the electrode. The use of ethyl vinyl ether in the solution above the chip effectively kept the Pd(II) reagent generated at the preselected electrode from migrating to neighboring electrodes and initiating Wacker oxidations at unwanted sites on the chip.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, Missouri 63130, and CombiMatrix Corporation, 6500 Harbor Heights Parkway, Suite 301, Mukilteo, Washington 98275, USA.
authors.forename: Eden
authors.initials: E
authors.lastname: Tesfu
authors.forename: Karl
authors.initials: K
authors.lastname: Maurer
authors.forename: Steven R
authors.initials: SR
authors.lastname: Ragsdale
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Moeller
mesh_terms: D019297:2,4-Dinitrophenol; D004563:Electrochemistry; D004566:Electrodes; D007202:Indicators and Reagents; D008838:Microcomputers; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D010165:Palladium; D019297:2,4-Dinitrophenol