title: Genomic analysis of Drosophila melanogaster telomeres: full-length copies of HeT-A and TART elements at telomeres.
abstract: The repetitive nature of heterochromatin hampers its analysis in general genome-sequencing projects. Specific studies are needed to extend the sequence into telomeric and centromeric heterochromatin. Drosophila telomeres lack the telomerase-generated repeats that are characteristic of other eukaryotic chromosomes. Instead, they consist of tandem arrays of HeT-A and TART elements. Herein, we present the genomic organization of the telomeres in the isogenic strain (y; cn bw sp) that was used for the Drosophila melanogaster sequencing project. The data indicate that the canonical features of telomere organization are widely conserved in evolution. In addition, we have identified full-length elements, likely competent elements, for HeT-A and TART.
authors.forename: José P
authors.initials: JP
authors.lastname: Abad
authors.forename: Beatriz
authors.initials: B
authors.lastname: De Pablos
authors.forename: Kazutoyo
authors.initials: K
authors.lastname: Osoegawa
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: De Jong
authors.forename: Antonia
authors.initials: A
authors.lastname: Martín-Gallardo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Villasante
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D019143:Evolution, Molecular; D015683:Gene Products, gag / Q000235:genetics*; D017344:Genes, Insect; D016678:Genome; D006570:Heterochromatin / Q000235:genetics; D008957:Models, Genetic; D008969:Molecular Sequence Data; D018626:Retroelements / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D016615:Telomere / Q000235:genetics
chemical_list: D029721:Drosophila Proteins; D015683:Gene Products, gag; C103996:HeT-A-gag protein, Drosophila; D006570:Heterochromatin; D018626:Retroelements; C469435:TART-element-gag protein, Drosophila