Effect of diets with different magnesium content in ischemic stroke rats.
Rats fed with low (0.015%), normal (0.08%) or high (0.32%) magnesium (Mg) diet for 5-6 weeks were subjected to photothrombosis-induced infarction. As compared to normal diet, Mg deprivation increased by 45% infarct volume at 24 h after photothrombosis but did not modify the lesion at 4 h after photothrombosis. Mg supplementation did not protect from infarction whatever the time point examined. No differences in pre-ischemic systolic blood pressure and glycemia as well as in post-ischemic kaliemia, calcemia and plasma antioxidant activity were observed between groups. However, plasma total Mg level correlated with plasma antioxidant activity at 4 h after photothrombosis. These results demonstrate that brains from Mg deficient rats are more susceptible to permanent focal ischemia than rats fed with normal or high Mg diet.
Demougeot
C
C
Laboratoire Physiologie-Pharmacie, Faculté de Médecine-Pharmacie, Besançon, France.
Bobillier-Chaumont
S
S
Mossiat
C
C
Marie
C
C
Berthelot
A
A
D000818:Animals; D002545:Brain Ischemia / Q000097:blood* / Q000178:diet therapy; D008274:Magnesium / Q000097:blood* / Q000494:pharmacology / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D020521:Stroke / Q000097:blood* / Q000178:diet therapy
D008274:Magnesium