Thermal analysis of laser interstitial thermotherapy in ex vivo fibro-fatty tissue using exponential functions.
A therapeutic procedure to treat small, surface breast tumours up to 10 mm in radius plus a 5 mm margin of healthy, surrounding tissue using laser interstitial thermotherapy (LITT) is currently being investigated. The purpose of this study is to analyse and model the thermal and coagulative response of ex vivo fibro-fatty tissue, a model for breast tissue, during experimental laser interstitial thermotherapy at 980 nm. Laser radiation at 980 nm was delivered interstitially through a diffusing tip optical fibre inserted into a fibro-fatty tissue model to produce controlled heating at powers ranging from 3.2 to 8.0 W. Tissue temperature was measured with thermocouples placed at 15 positions around the fibre. The induced coagulation zone was measured on gross anatomical sections. Thermal analysis indicates that a finite sum of exponential functions is an approximate solution to the heat conduction equation that more accurately predicts the time-temperature dependence in tissue prior to carbonization (T < 100 degrees C) during LITT than the traditional model using a single exponential function. Analysis of the ellipsoid coagulation volume induced in tissue indicates that the 980 nm wavelength does not penetrate deep enough in fibro-fatty tissue to produce a desired 30 mm diameter (14.1 x 10(3) mm3) coagulation volume without unwanted tissue liquefaction and carbonization.
Salas
Nelson
N
Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, PO Box 248294, Coral Gables, FL 33124, USA. nsalas@med.miami.edu
Manns
Fabrice
F
Milne
Peter J
PJ
Denham
David B
DB
Minhaj
Ahmed M
AM
Parel
Jean-Marie
JM
Robinson
David S
DS
D000273:Adipose Tissue / Q000528:radiation effects*; D000818:Animals; D001943:Breast Neoplasms / Q000532:radiotherapy; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D053685:Laser Therapy; D008954:Models, Biological; D011827:Radiation; D013552:Swine; D013696:Temperature; D013997:Time Factors