The role of botulinum toxin in neurourology.
Botulinum toxin is a presynaptic neuromuscular blocking agent that induces a selective and reversible muscle weakness of up to several months when injected intramuscularly in minute quantities. Different medical disciplines have applied the toxin to treat mainly muscular hypercontraction. For neurourologically impaired patients, the reported successful treatment of neurogenic detrusor overactivity and detrusor sphincter dyssynergia with botulinum-A toxin is a promising alternative option to conservative medication or surgery. This review of the literature presents current indications, techniques for and results of the use of botulinum toxin in neurourologically impaired patients and aims to give an insight into this new therapeutic option.
Schurch
Brigitte
B
Neurourology, Swiss Paraplegic Center, Balgrist University Hospital, Zurich, Switzerland. schurchb@balgrist.unizh.ch
D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D009466:Neuromuscular Blocking Agents / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D013119:Spinal Cord Injuries / Q000150:complications; D014524:Urethral Obstruction / Q000188:drug therapy / Q000209:etiology; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy / Q000209:etiology; D014549:Urinary Incontinence / Q000188:drug therapy / Q000209:etiology; D014570:Urologic Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D009466:Neuromuscular Blocking Agents; D019274:Botulinum Toxins, Type A