Molecular and cell biology of Legionella pneumophila.
Legionella pneumophila is a facultative intracellular pathogen that can replicate within phagocytic host cells such as protozoa and macrophages. Evasion of phagocytic killing is mediated by the type IV Dot/Icm secretion system, which exports bacterial effectors that modulate biogenesis of the phagosome to evade endocytic fusion and also to intercept vesicles derived from the endoplasmic reticulum. Bacterial replication is associated with activation of caspase-3 in infected macrophages and is culminated in apoptosis and pore formation-mediated cytolysis of the host.
Bitar
Dina M
DM
Department of Microbiology and Immunology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Molmeret
Maëlle
M
Abu Kwaik
Yousef
Y
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D006801:Humans; D016952:Legionella pneumophila / Q000254:growth & development / Q000276:immunology / Q000502:physiology* / Q000648:ultrastructure; D007877:Legionnaires' Disease / Q000382:microbiology; D016676:Macrophages, Alveolar / Q000382:microbiology*; D051379:Mice; D008854:Microscopy, Electron; D010588:Phagosomes / Q000378:metabolism; D020298:U937 Cells
C505407:CASP3 protein, human; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases