title: Pump-induced haemolysis: a comparison of short-term ventricular assist devices.
abstract: Centrifugal pumps are superior to roller pumps for extended support durations in terms of pump-induced haemolysis. In this study, we evaluated the commonly used Biomedicus BP 50 and compared it with the Jostra Rotaflow and a standard roller pump in an in vitro test circuit. Each circuit was run for a six-day period and repeated five times. Plasma haemoglobin values showed the roller pump to become more haemolytic than the Biomedicus (p = 0.022) and the Rotaflow. A statistically significant difference between the Biomedicus and the Rotaflow was observed on day six of the trial (p = 0.016), with the Rotaflow showing lower levels of haemolysis than the Biomedicus. These results support the use of the new generation centrifugal pump, the Rotaflow, as a suitable device for short-term ventricular assist.
authors.affiliation: Cardiac Surgical Unit, Royal Children's Hospital, Parkville, Victoria, Australia. martin.bennett@rch.org.au
authors.forename: M
authors.initials: M
authors.lastname: Bennett
authors.forename: S
authors.initials: S
authors.lastname: Horton
authors.forename: C
authors.initials: C
authors.lastname: Thuys
authors.forename: S
authors.initials: S
authors.lastname: Augustin
authors.forename: M
authors.initials: M
authors.lastname: Rosenberg
authors.forename: C
authors.initials: C
authors.lastname: Brizard
mesh_terms: D001243:Assisted Circulation / Q000009:adverse effects* / Q000295:instrumentation*; D001774:Blood Chemical Analysis; D001783:Blood Flow Velocity; D002498:Centrifugation; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D011673:Pulsatile Flow; D015203:Reproducibility of Results
chemical_list: D006454:Hemoglobins