title: Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
abstract: Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, OH 45267 0529, USA. yuri.nikiforov@uc.edu
authors.forename: Marina N
authors.initials: MN
authors.lastname: Nikiforova
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ciampi
authors.forename: Giuliana
authors.initials: G
authors.lastname: Salvatore
authors.forename: Massimo
authors.initials: M
authors.lastname: Santoro
authors.forename: Manoj
authors.initials: M
authors.lastname: Gandhi
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Knauf
authors.forename: Gerry A
authors.initials: GA
authors.lastname: Thomas
authors.forename: Stephen
authors.initials: S
authors.lastname: Jeremiah
authors.forename: Tatyana I
authors.initials: TI
authors.lastname: Bogdanova
authors.forename: Mykola D
authors.initials: MD
authors.lastname: Tronko
authors.forename: James A
authors.initials: JA
authors.lastname: Fagin
authors.forename: Yuri E
authors.initials: YE
authors.lastname: Nikiforov
mesh_terms: D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000378:metabolism; D002648:Child; D006801:Humans; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000378:metabolism; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf / Q000096:biosynthesis* / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013696:Temperature; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism
chemical_list: D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf