title: The significance of the degree of myometrial invasion in patients with stage IB endometrial cancer.
abstract: OBJECTIVE
  To study the validity of the FIGO staging classification of endometrial cancer Stage IB by correlating degree of myometrial invasion depth with outcome measures.
  
  
  METHODS
  Fifty patients with endometrial adenocarcinoma FIGO Stage IB who underwent hysterectomy between 1989 and 2001 were divided into two groups according to depth of myometrial invasion. The first group comprised of 31 patients with myometrial invasion of less than or equal to one-third. The second group included 19 patients with invasion greater than one-third but less than one-half. The two groups were compared with regard to prognostic factors and outcome measures.
  
  
  RESULTS
  The overall 5-year recurrence-free survival, disease specific survival and overall survival rates were 87%, 94% and 77%, respectively. These outcome measures did not vary significantly between the two groups. There were no statistically significant differences between the two groups with regard to the following parameters: duration of follow-up, age, proportion of patients who underwent complete surgical staging and postoperative adjuvant radiotherapy. Histologic parameters of the two groups, such as histological type, grade and proportion of patients with capillary space-like involvement and lower uterine segment involvement were not significantly different.
  
  
  CONCLUSIONS
  In patients with Stage IB endometrial cancer the amount of myometrial invasion defined as less than one third compared with invasion greater than one third does not appear to correlate with their outcome, thus validating the FIGO staging system.
authors.affiliation: Department of Obstetrics and Gynecology, Barzilai Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ashkelon, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Gemer
authors.forename: L
authors.initials: L
authors.lastname: Uriev
authors.forename: T
authors.initials: T
authors.lastname: Harkovsky
authors.forename: R
authors.initials: R
authors.lastname: Peled
authors.forename: D
authors.initials: D
authors.lastname: Ben-Dor
authors.forename: F
authors.initials: F
authors.lastname: Barak
authors.forename: S
authors.initials: S
authors.lastname: Segal
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007557:Israel; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D009367:Neoplasm Staging / Q000592:standards*; D011379:Prognosis; D015203:Reproducibility of Results; D016019:Survival Analysis