title: [Clinic effect of alendronate sodium treatment in osteoporosis patients with hip fracture].
abstract: OBJECTIVE
  To assess efficacy and safety of alendronate sodium treatment in osteoporosis patients with hip fracture.
  
  
  METHODS
  One year randomized, double-blind clinical trial was carried out in 77 osteoporosis patients with hip fracture. The bone mineral density (BMD) in lumbar spine (L(2 - 4)), femoral neck (Neck), Wards triangle (Wards) and great trochanter (Troch) was measured by dual energy x-ray absorptiometer (DEXA).
  
  
  RESULTS
  In our study, alendronate sodium induced marked increases in BMD of the L(2 - 4) (7.0% +/- 13.0%), Neck (7.3% +/- 11.1%), Wards (4.6% +/- 5.9%), Troch (4.5% +/- 3.2%) (mean +/- s) versus decreases of 2.0% +/- 4.5%, -0.9% +/- 6.9%, 3.6% +/- 4.9% and 1.14% +/- 6.0% with placebo (P < 0.05). Blood Ca, P, ALP, BGP and Urine Pyd/C were no significant difference between before and after therapy. There were usually mild and transient side-effect, such as gastrointestinal symptoms.
  
  
  CONCLUSIONS
  Alendronate is an efficacy and safety drug in treatment of osteoporosis.
authors.affiliation: Department of Orthopeadic, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Gui-xing
authors.initials: GX
authors.lastname: Qiu
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Wu
authors.forename: Jian-xiong
authors.initials: JX
authors.lastname: Shen
authors.forename: Xian-zheng
authors.initials: XZ
authors.lastname: Luo
authors.forename: Hai
authors.initials: H
authors.lastname: Tang
authors.forename: Yi-peng
authors.initials: YP
authors.lastname: Wang
authors.forename: Xi-sheng
authors.initials: XS
authors.lastname: Weng
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Lin
authors.forename: Jin
authors.initials: J
authors.lastname: Jin
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.forename: Jian-guo
authors.initials: JG
authors.lastname: Zhang
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D019386:Alendronate / Q000494:pharmacology / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D004311:Double-Blind Method; D005260:Female; D006620:Hip Fractures / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000410:Alanine Transaminase; D002118:Calcium; D019386:Alendronate