R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men.
BACKGROUND
The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial.


RESULTS
The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1+/-40.9 U/L) than in controls (44.8+/-20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7+/-15.7%) and controls (87.0+/-9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001).


CONCLUSIONS
The Q allele may be protective against premature MI.
Ogawa
Masakazu
M
Department of Cardiovascular, Graduate School of Medicine, Kagoshima University, Japan.
Abe
Satoshi
S
Biro
Sadatoshi
S
Saigo
Masahiko
M
Kihara
Takashi
T
Setoyama
Shiro
S
Matsuoka
Tatsuru
T
Toda
Hitoshi
H
Torii
Hiroyuki
H
Atsuchi
Yoshihiko
Y
Toyama
Yoshifumi
Y
Tateishi
Shigeki
S
Minagoe
Shinichi
S
Maruyama
Ikuro
I
Tei
Chuwa
C
D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D015942:Factor VIIa / Q000032:analysis / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
D015942:Factor VIIa