[Relation between resistance to oxidation and cholesterol acceptance of high density lipoproteins in patients with ischemic heart disease].
Cholesterol (CH) acceptance ability of high density lipoproteins (HDL) was assessed in 43 ischemic heart disease (IHD) patients, including patients with post-infarction cardiosclerosis and class II-III effort angina. CH acceptance ability of HDL was measured as increment of HDL CH after incubation with artificial CH-containing system. Oxidabilities of HDL and total plasma were estimated by quantitation of lipid peroxidation products (hydroperoxides and thiobarbituric acid-reactive substances - TBARS) after incubation with Cu(2+) ions. HDL fraction (after apo B lipoproteins removal) of IHD patients appeared to include 2 times less additive CH compared with donor's HDL despite lower (-12%) HDL CH level. Negative correlation (r =-0.38, p<0.05) existed between formed TBARS in HDL and HDL CH acceptance. In total plasma of IHD patients elevation of both formed TBARS and particularly hydroperoxides was observed. Parallelism between decrease of CH acceptance by HDL, oxidability of HDL and of total plasma testifies on weakness not only of CH-accepting, but also of antioxidant HDL functions in IHD patients.
Drinitsina
S V
SV
Research Institute for Physicochemical Medicine, ul. Malaya Pirogovskaya, 1a, 119828 Moscow, Russia; I. M. Sechenov Moscow Medical Academy; ul. Bolshaya Pirogovskaya, 2/6, 119882 Moscow, Russia.
Torkhovskaia
T I
TI
Azizova
O A
OA
Ivanova
L I
LI
Solov'eva
N P
NP
Khalilov
E M
EM
Kliuchnikova
Zh I
ZhI
Ivanov
G G
GG
Lopukhin
Iu M
IuM
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000378:metabolism; D003324:Coronary Artery Disease; D006801:Humans; D015227:Lipid Peroxidation; D008075:Lipoproteins, HDL / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D017392:Thiobarbituric Acid Reactive Substances; D002784:Cholesterol