title: Diversity of enteric viruses detected in patients with gastroenteritis in a tertiary referral paediatric hospital.
abstract: The genetic diversity of enteric viruses co-circulating in a cohort of patients with viral gastroenteritis in a large tertiary paediatric hospital in London, UK, was determined. Multiple strains of noroviruses (NV), sapoviruses (SV) and astroviruses (HAsV) were detected in these patients, indicating the likelihood of multiple introductions from different sources, possible sub-clinical infections and simultaneous infection with different viruses in immunocompromised and other patients. Routine screening of immunocompromised patients and infection control procedures are important to prevent nosocomial infection.
authors.affiliation: Enteric Virus Unit, Enteric, Respiratory and Neurological Virus Laboratory, Central Public Health Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London, United Kingdom. christopher.gallimore@hpa/org.uk
authors.forename: Chris I
authors.initials: CI
authors.lastname: Gallimore
authors.forename: David W
authors.initials: DW
authors.lastname: Cubitt
authors.forename: Alison F
authors.initials: AF
authors.lastname: Richards
authors.forename: Jim J
authors.initials: JJ
authors.lastname: Gray
mesh_terms: D000293:Adolescent; D019350:Astroviridae Infections / Q000453:epidemiology / Q000821:virology*; D017250:Caliciviridae Infections / Q000453:epidemiology / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology / Q000821:virology; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000821:virology*; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D008131:London; D001257:Mamastrovirus / Q000235:genetics* / Q000302:isolation & purification; D029322:Norovirus / Q000235:genetics* / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D029341:Sapovirus / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017385:Sequence Homology
chemical_list: D012367:RNA, Viral