[Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B infection].
OBJECTIVE
To explore the role of chemokine receptor CXCR3 in pathogenesis of chronic hepatitis B.


METHODS
The expression of CXCR3 on peripheral blood lymphocytes from chronic hepatitis B patients with various degrees of inflammation was detected, and the distributions of CXCR3 on CD4(+) and CD8(+) T lymphocytes were also evaluated by FACS.


RESULTS
As compared with healthy control, the percentages of CXCR3(+) lymphocytes, monocytes and CD8(+) T cells were increased significantly in chronic hepatitis B patients.


CONCLUSIONS
Above data suggest that chemokine receptor CXCR3 may play an important role in the recruitment of lymphocytes, especially CTLs recruited to inflammation sites.
Shi
Li-Yun
LY
Institute of Immunology, The First Affiliated Hospital, Zhejiang University, Hangzhou 310016, China.
Zhang
Li-Huang
LH
Li
Ming-Wei
MW
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000378:metabolism; D006801:Humans; D009000:Monocytes / Q000378:metabolism; D054367:Receptors, CXCR3 / Q000276:immunology; D019707:Receptors, Chemokine; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D054367:Receptors, CXCR3; D019707:Receptors, Chemokine