Anticonvulsant activity of Mimosa pudica decoction.
The decoction of Mimosa pudica leaves given intraperitoneally at dose of 1000-4000 mg/kg protected mice against pentylentetrazol and strychnine-induced seizures. M. pudica had no effect against picrotoxin-induced seizures It also antagonized N-methyl-D-aspartate- induced turning behavior. These properties could explain its use in African traditional medicine.
Ngo Bum
E
E
Département des Sciences Biologiques, Faculté des Sciences, Université de Ngaoundéré B.P. 454 Ngaoundéré, BP, Cameroon. eli_bum@yahoo.fr
Dawack
D L
DL
Schmutz
M
M
Rakotonirina
A
A
Rakotonirina
S V
SV
Portet
C
C
Jeker
A
A
Olpe
H-R
HR
Herrling
P
P
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D016488:Medicine, African Traditional; D051379:Mice; D031298:Mimosa; D010433:Pentylenetetrazole; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013331:Strychnine
D000927:Anticonvulsants; D010936:Plant Extracts; D013331:Strychnine; D010433:Pentylenetetrazole