title: [Effect of Kampo medicines on the peripheral blood flow rate of betamethason-induced Oketsu syndrome mice by laser Doppler flow meter].
abstract: Stagnation of peripheral blood flow is the cause of various diseases. Changes in peripheral blood flow after oral administration of Kampo medicines in mice with betamethasone-induced oketsu syndrome and normal mice were examined using a laser Doppler blood flow meter. The Kampo medicines used were: Toki-shakuyaku-san; Kami-shoyo-san; Keishi-bukuryo-gan; Daio-botanpi-to; Tokaku-joki-to; Goshuyu-to; and Hange-koboku-to. In the oketsu mice, blood flow was improved by single-dose administration of Toki-shakuyaku-san, Kami-shoyo-san, Keishi-bukuryo-gan, Daio-botanpi-to, Tokaku-joki-to, and Goshuyu-to, but only Toki-shakuyaku-san increased blood flow significantly in normal mice. In addition, blood flow decreased after single-dose administration of Keishi-bukuryo-gan, Daio-botanpi-to, and Tokaku-joki-to in normal mice.
authors.affiliation: Department of Phytochemistry, Tohoku Pharmaceutical University, Sendai, Japan.
authors.forename: Joji
authors.initials: J
authors.lastname: Ueda
authors.forename: Etsuko
authors.initials: E
authors.lastname: Ohya
authors.forename: Kozue
authors.initials: K
authors.lastname: Udagawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Hara
authors.forename: Mai
authors.initials: M
authors.lastname: Fukui
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Yamagishi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Takaaki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ohsawa
mesh_terms: D000818:Animals; D001623:Betamethasone; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000503:physiopathology*; D001783:Blood Flow Velocity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008833:Microcirculation / Q000187:drug effects* / Q000503:physiopathology; D013268:Stimulation, Chemical; D013577:Syndrome
chemical_list: D004365:Drugs, Chinese Herbal; D001623:Betamethasone