title: Molecular cloning and characterization of three adult rat beta-globin gene promoters.
abstract: We analyzed the promoter regions of the adult rat beta (IIbeta, IIIbeta, and 0beta)-globin genes. The results indicated that (1) the activities of the minimal promoters of these three genes are proportional to the gene expression levels in vivo, and (2) erythroid-specific repressor regions are located immediately upstream of the minimal promoter sequences and are regulated by the same transcription factor.
authors.affiliation: Department of First Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo, Tokyo 113-8602, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okumura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujii
authors.forename: Naomi
authors.initials: N
authors.lastname: Inokuchi
authors.forename: Michiaki
authors.initials: M
authors.lastname: Watanabe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishino
authors.forename: Taro
authors.initials: T
authors.lastname: Okazaki
mesh_terms: D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D015500:Chloramphenicol O-Acetyltransferase / Q000378:metabolism; D003001:Cloning, Molecular; D004247:DNA / Q000737:chemistry; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D015723:Gene Library; D005914:Globins / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D051381:Rats; D014157:Transcription Factors; D014162:Transfection
chemical_list: D014157:Transcription Factors; D005914:Globins; D004247:DNA; D015500:Chloramphenicol O-Acetyltransferase