Image contrast agents activated by prostate specific antigen (PSA).
A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and alpha-chymotrypsin, releasing free fluorophore via cleavage of a three-component system.
Jones
Graham B
GB
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA. gr.jones@neu.edu
Xie
Longfei
L
El-Shafey
Ahmed
A
Crasto
Curtis F
CF
Bubley
Glenn J
GJ
D'Amico
Anthony V
AV
D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism*; D017430:Prostate-Specific Antigen / Q000378:metabolism*
D003287:Contrast Media; D017430:Prostate-Specific Antigen