title: Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors.
abstract: The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against two human carcinoma cell lines. These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. zhu_guoxin@lilly.com
authors.forename: Guoxin
authors.initials: G
authors.lastname: Zhu
authors.forename: Scott E
authors.initials: SE
authors.lastname: Conner
authors.forename: Xun
authors.initials: X
authors.lastname: Zhou
authors.forename: Ho-Kit
authors.initials: HK
authors.lastname: Chan
authors.forename: Chuan
authors.initials: C
authors.lastname: Shih
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Engler
authors.forename: Rima S
authors.initials: RS
authors.lastname: Al-Awar
authors.forename: Harold B
authors.initials: HB
authors.lastname: Brooks
authors.forename: Scott A
authors.initials: SA
authors.lastname: Watkins
authors.forename: Charles D
authors.initials: CD
authors.lastname: Spencer
authors.forename: Richard M
authors.initials: RM
authors.lastname: Schultz
authors.forename: Jack A
authors.initials: JA
authors.lastname: Dempsey
authors.forename: Eileen L
authors.initials: EL
authors.lastname: Considine
authors.forename: Bharvin R
authors.initials: BR
authors.lastname: Patel
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Ogg
authors.forename: Vasu
authors.initials: V
authors.lastname: Vasudevan
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Lytle
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006131:Growth Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D007211:Indoles; D047428:Protein Kinase Inhibitors; D018844:Cyclin-Dependent Kinases