title: Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions.
abstract: mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.
authors.affiliation: Department of Molecular Biology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
authors.forename: Ronen
authors.initials: R
authors.lastname: Hazan
authors.forename: Boaz
authors.initials: B
authors.lastname: Sat
authors.forename: Hanna
authors.initials: H
authors.lastname: Engelberg-Kulka
mesh_terms: D016923:Cell Death; D004268:DNA-Binding Proteins / Q000502:physiology*; D004722:Endoribonucleases; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000502:physiology*; D006358:Hot Temperature; D018384:Oxidative Stress
chemical_list: D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C422954:MazE protein, E coli; C422955:MazF protein, E coli; D004722:Endoribonucleases