title: [Evaluation on biocompatibility of Ti-Fe-Mo-Mn-Nb-Zr alloy].
abstract: In this study, the general toxicity tests including acute toxicity test, haemolysis test, MTT assay of Ti-Fe-Mo-Mn-Nb-Zr alloys were carried out. The morphology of these cells was also observed under phase-contrast microscope. By using X-ray photoelectron spectroscopy(XPS), the kind and mol% of element in surface film were studied. The kind and concentration of element in dipping fluid were investigated by ICP atomic emission spectrometry. The results showed the primary component is TiO2 in surface film. The dipping fluid of Ti-Fe-Mo-Mn-Nb-Zr alloys contains Fe 0.2-1.07 mg/l and Mn 0.16-0.5 mg/l; such dental materials are beneficial to health. No cytotoxic effect was disclosed by in vitro and in vivo tests. The level of cytotoxicity was grade 0 and 1; the haemolysis degree was 0.558%-0.642%, i.e. less than 5%. The cells growing in the extract showed normal morphology. These data indicate that Ti-Fe-Mo-Mn-Nb-Zr alloy, as a dental material, has good biocompatibility.
authors.affiliation: Key Laboratory for Automobile Materials of the Ministry of Education, College of Materials Science and Engineering, Jilin University, Changchun 130025, China.
authors.forename: Sirong
authors.initials: S
authors.lastname: Yu
authors.forename: Xinping
authors.initials: X
authors.lastname: Zhang
authors.forename: Fengxue
authors.initials: F
authors.lastname: Lao
authors.forename: Xuejun
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhenming
authors.initials: Z
authors.lastname: He
authors.forename: Yaohui
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhonghui
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000633:toxicity*; D003722:Dental Alloys / Q000633:toxicity*; D007501:Iron / Q000633:toxicity; D008297:Male; D008345:Manganese; D051379:Mice; D008982:Molybdenum / Q000633:toxicity; D009556:Niobium / Q000633:toxicity; D009996:Osmotic Fragility; D011817:Rabbits; D011897:Random Allocation; D013052:Spectrometry, X-Ray Emission; D014025:Titanium / Q000633:toxicity*; D015040:Zirconium / Q000633:toxicity
chemical_list: D001672:Biocompatible Materials; D003722:Dental Alloys; D009556:Niobium; D008345:Manganese; D008982:Molybdenum; D015040:Zirconium; D014025:Titanium; D007501:Iron