title: Role of Streptococcus pyogenes two-component response regulators in the temporal control of Mga and the Mga-regulated virulence gene emm.
abstract: We examined the role of Streptococcus pyogenes two-component response regulators (SptR) in expression of Mga and the Mga-regulated gene emm. Both serotype M6 and serotype M1 mutants in 12 of the 13 identified sptR genes exhibited levels of emm transcripts and Mga protein comparable to those of the wild type during exponential and stationary phases of growth. Thus, temporal control of these virulence genes does not require Spt response regulators.
authors.affiliation: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9048, USA.
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Ribardo
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Lambert
authors.forename: Kevin S
authors.initials: KS
authors.lastname: McIver
mesh_terms: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D009154:Mutation; D012703:Serotyping; D015398:Signal Transduction; D013297:Streptococcus pyogenes / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism / Q000472:pathogenicity; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; C014689:streptococcal M protein; C068267:mry protein, Streptococcus pyogenes