Low prevalence of BRAF mutations in radiation-induced thyroid tumors in contrast to sporadic papillary carcinomas.
Point mutations of the BRAF gene have been recently described with high prevalence in papillary thyroid carcinomas. However, this molecular alteration has not been studied in radiation-induced thyroid tumors. We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas. Radiation-induced tumors demonstrated a low prevalence (4%) of BRAF point mutations and high prevalence (58%) of RET/PTC rearrangements. Sporadic papillary carcinomas revealed a clearly distinct pattern, with 37% of tumors harboring BRAF mutations and 20% RET/PTC rearrangements. These results demonstrate a significant difference in the molecular genetic profile of sporadic and radiation-induced thyroid tumors.
Nikiforova
Marina N
MN
Department of Pathology and Laboratory Medicine, University of Cincinnati, 231 Albert Sabin Way, P.O. Box 670529, Cincinnati, OH 45267 0529, USA. yuri.nikiforov@uc.edu
Ciampi
Raffaele
R
Salvatore
Giuliana
G
Santoro
Massimo
M
Gandhi
Manoj
M
Knauf
Jeffrey A
JA
Thomas
Gerry A
GA
Jeremiah
Stephen
S
Bogdanova
Tatyana I
TI
Tronko
Mykola D
MD
Fagin
James A
JA
Nikiforov
Yuri E
YE
D000293:Adolescent; D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000378:metabolism; D002648:Child; D006801:Humans; D009154:Mutation; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000378:metabolism; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf / Q000096:biosynthesis* / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D013696:Temperature; D013964:Thyroid Neoplasms / Q000209:etiology* / Q000235:genetics* / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf