Transfer of specific antibodies results in increased expression of TNF-alpha and IL12 and recruitment of neutrophils to the site of a cutaneous Francisella tularensis infection.
This study demonstrates that passive transfer of Francisella tularensis-specific antibodies before experimental cutaneous infection with the live vaccine strain of F. tularensis has profound effects. Recipient mice showed stronger staining for TNF-alpha and IL12, and larger numbers of neutrophils in skin samples after infection than control mice.
Stenmark
Stephan
S
Departments of Clinical Microbiology, Infectious Diseases1 and Clinical Bacteriology2, Umeå University, Umeå, Sweden.
Sjöstedt
Anders
A
Departments of Clinical Microbiology, Infectious Diseases1 and Clinical Bacteriology2, Umeå University, Umeå, Sweden.
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage*; D000918:Antibody Specificity; D004195:Disease Models, Animal; D005604:Francisella tularensis / Q000276:immunology; D007106:Immune Sera / Q000008:administration & dosage; D007116:Immunization, Passive; D007150:Immunohistochemistry; D007274:Injections, Intraperitoneal; D018664:Interleukin-12 / Q000032:analysis*; D051379:Mice; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration; D012867:Skin / Q000276:immunology*; D017192:Skin Diseases, Bacterial / Q000276:immunology / Q000517:prevention & control*; D014406:Tularemia / Q000276:immunology / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D000907:Antibodies, Bacterial; D007106:Immune Sera; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12