title: Decreased platelet aggregation of platelet concentrate during storage recovers in the body after transfusion.
abstract: BACKGROUND
  Previous reports have shown that storage decrease the ability of PLTs to aggregate in the form of PLT concentrate (PC). Nevertheless, there are few reports that have studied the PLT function in blood samples obtained from recipients after PLT transfusion. In this study, this issue was addressed by examining the ability of PLTs to aggregate after being transfused into the blood stream.
  
  
  METHODS
  PC was transfused to the patients with extremely low PLT counts resulting from chemotherapy. The maximum extent of PLT aggregation and size of the aggregates were compared between PLT in stored PC before transfusion with the PLT-rich plasma (PRP) from the recipients after transfusion and with PRP from patients with moderate decrease in PLT counts after chemotherapy.
  
  
  RESULTS
  The maximum extent of PLT aggregation was significantly higher in PRP collected from the patients after transfusion compared to the extent obtained before transfusion. There were no significant differences in the maximum extents of PLT aggregation between the PRP collected from the recipients after PC transfusion and, in the same patients, when PLT counts were moderately low.
  
  
  CONCLUSIONS
  These results suggest that the observed decreased in PLT aggregation after storage can improve in the body after transfusion, and transfused PLTs have similar aggregation ability compared to the PLTs derived from the patient.
authors.affiliation: Department of Pediatrics and Transfusion Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. mryosuke@med.uoeh-u.ac.jp
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Miyaji
authors.forename: Michio
authors.initials: M
authors.lastname: Sakai
authors.forename: Hajime
authors.initials: H
authors.lastname: Urano
authors.forename: Koichi
authors.initials: K
authors.lastname: Nakata
authors.forename: Hisahi
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Shirahata
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001793:Blood Preservation; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D007938:Leukemia / Q000097:blood / Q000150:complications / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000097:blood / Q000150:complications / Q000188:drug therapy; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D017713:Platelet Transfusion; D020127:Recovery of Function; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000628:therapy; D013997:Time Factors
chemical_list: D000244:Adenosine Diphosphate; D003094:Collagen