Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives.
Novel derivatives of arachidonyl alcohol were synthesized and evaluated for their CB1 receptor activity by [(35)S]GTP(gamma)S assay using rat cerebellar membranes.
Parkkari
Teija
T
Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland. teija.parkkari@uku.fi
Savinainen
Juha R
JR
Rauhala
Anu L
AL
Tolonen
Tiina L
TL
Nevalainen
Tapio
T
Laitinen
Jarmo T
JT
Gynther
Jukka
J
Järvinen
Tomi
T
D000438:Alcohols / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D001095:Arachidonic Acids / Q000138:chemical synthesis* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism*
D000438:Alcohols; D001095:Arachidonic Acids; D043884:Receptor, Cannabinoid, CB1