[Study on the influence of simulative EEG modulation magnetic field on the discharge of median raphe nuclei].
In this paper the response characteristic of the nerve fiber to the modulation magnetic field induction is studied by using the method of numeric simulation. It is found that the nerve fiber is sensitive to the low frequency modulated signal but not to the high frequency carrier wave. A simulative EEG signal generator is developed according to the change of EEG rhythm during the sleep. The simulative EEG square wave is modulated by high-frequency magnetic impulse. The modulation magnetic field is coupled into the rabbit's brain to study the influence of magnetic stimulation on the discharge of 5-hydroxytryptamine (5-HT) nerve cell. The experiment results demonstrate that discharge frequency of median raphe nuclei related to sleep changes significantly and the discharge becomes slow, which shows that magnetic stimulation can inhibit electrical activity of 5-HT nerve cell and provide a new way to improve insomnia.
Wang
Mingshi
M
College of Precision Instrument and Opto-electronics Engineering, Tianjin University, Tianjin 300072, China.
Li
Yuezhi
Y
Wang
Xuemin
X
Guo
Mingxia
M
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology; D003198:Computer Simulation; D004569:Electroencephalography; D004574:Electromagnetic Fields; D004594:Electrophysiology; D006801:Humans; D009474:Neurons / Q000502:physiology; D011817:Rabbits; D011903:Raphe Nuclei / Q000378:metabolism / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D012890:Sleep / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000378:metabolism / Q000503:physiopathology
D012701:Serotonin