title: Interaction between a perfluorocarbon emulsion and radiographic contrast media.
abstract: This study evaluated specially designed perfluorocarbon (PFC) emulsions as blood substitutes in case of induced ischemia of the left heart ventricle in healthy farm pigs. Two hundred ml of perfluorocarbon emulsion were infused while 200 ml of blood were simultaneously drawn. Radiographic contrast media were given to aid placement of balloon catheters in the left coronary artery. Histopathological analysis showed that right heart failure caused the deaths of both pigs. Particles (up to>3 micro) of foreign body materials obstructed capillaries of all organs analyzed (heart, lung, liver, kidneys and spleen). Laboratory investigation showed severe interference between the PFC emulsion and radiographic contrast media, resulting in the deterioration of the PFC emulsion. The strongest interference occurred when PFC emulsion and Accupaque interacted; particle size started at an initial 311 nm and went up to >3 micro within seconds. Great care must be taken when PFC emulsions are used in combination with x-ray contrast media. None of the described radiographic contrast media should be used within 48 hours prior to the use of this PFC emulsion. Also, the use of these contrast media should be avoided for a certain period of time after using PFC emulsion. The mechanisms of elimination of PFC emulsions from the circulation are not completely understood and has yet to be evaluated.
authors.affiliation: University of Ulm, ZIBMT, Department of Biomaterials, Albert-Einstein-Allee 47, D-89081 Ulm, Germany.
authors.forename: Ralf-Peter
authors.initials: RP
authors.lastname: Franke
authors.forename: Peter
authors.initials: P
authors.lastname: Reuter
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Röhlke
authors.forename: Klaus
authors.initials: K
authors.lastname: Matschke
authors.forename: Steffi
authors.initials: S
authors.lastname: Keller
authors.forename: Bernd
authors.initials: B
authors.lastname: Klosterhalfen
authors.forename: Christian
authors.initials: C
authors.lastname: Mittermayer
authors.forename: Christoph
authors.initials: C
authors.lastname: Mrowietz
authors.forename: Friedrich
authors.initials: F
authors.lastname: Jung
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001802:Blood Substitutes / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D004347:Drug Interactions; D005466:Fluorocarbons / Q000009:adverse effects*; D006323:Heart Arrest / Q000139:chemically induced*; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D011859:Radiography; D013552:Swine
chemical_list: D001802:Blood Substitutes; D003287:Contrast Media; D005466:Fluorocarbons