title: (Iso) Prostaglandins in saliva indicate oxidation injury after radioiodine therapy.
abstract: As salivary glands concentrate radioiodine the radiation injury associated with 131I-therapy may result in sialoadenitis and xerostoma leading to a lasting impaired quality of life. Recently we reported about prostaglandin concentration changes as biochemical markers for radiation injury. Isoprostanes, a new family of prostaglandin-like compounds, have been demonstrated to be reliable markers for oxidation injury in vivo.
  
  
  METHODS
  In this study we examined the levels of 8-epi-PGF2alpha, the major member of the isoprostane family in 24 patients undergoing 1311 treatment in different doses for hyperthyroidism and differentiated thyroid cancer. 6 healthy sex and age-matched volunteers were monitored in parallel. Saliva(iso)prostaglandins were determined before 131I treatment, as well as 1, 3, 7, 14, 21, and 28 days, and 2, 3, and 6 months after therapy.
  
  
  RESULTS
  8-epi-PGF2alpha showed a significant 1311 dose-dependent temporary increase. The alterations were comparable in all investigated patients and significantly higher in cigarette smokers. TXB2 and 6-oxo-PGF, showed a dose-dependent increase too. TXB2 was higher in cigarette smokers and 6-oxo-PGF1alpha lower as compared to non-smokers.
  
  
  CONCLUSIONS
  These results clearly demonstrate a dose- and time-dependent tissue (TXB2, 6-oxo-PGF1alpha) and oxidation in-jury (8-epi-PGF2alpha) after 131I-therapy in the salivary glands.
authors.affiliation: Departments of Angiology, University of Vienna, Austria.
authors.forename: R M
authors.initials: RM
authors.lastname: Wolfram
authors.forename: B
authors.initials: B
authors.lastname: Palumbo
authors.forename: F
authors.initials: F
authors.lastname: Chehne
authors.forename: R
authors.initials: R
authors.lastname: Palumbo
authors.forename: A C
authors.initials: AC
authors.lastname: Budinsky
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D028421:Isoprostanes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011832:Radiation Injuries / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry*
chemical_list: D028421:Isoprostanes