T cell receptor delta-chain gene rearrangement in a novel case of adult NK cell leukemia.
Malignancies arising from natural killer (NK) cells are being increasingly recognized as distinct clinicopathological entities. We here report the characteristics of a peculiar case of NK-cell acute leukemia with unusual agranular morphology and rearrangement of the T-cell receptor (TCR) delta-chain gene.
Stagno
Fabio
F
Hematology, University of Catania, Catania, Italy. fsematol@tiscali.it
Guglielmo
Patrizia
P
Lo Nigro
Luca
L
Santonocito
Annamaria
A
Giustolisi
Rosario
R
D000208:Acute Disease; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001856:Bone Marrow Examination; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D019676:Genes, T-Cell Receptor delta / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology* / Q000648:ultrastructure; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D015458:Leukemia, T-Cell / Q000235:genetics* / Q000473:pathology; D008297:Male
D015703:Antigens, CD