Treatment strategies for uterine leiomyoma: the role of hormonal modulation.
Uterine leiomyomas are the most common gynecological tumors and are a significant health concern for many women. Although the exact etiology of these tumors is unknown, epidemiological and experimental animal studies have established a role for ovarian hormones in the pathogenesis of this disease. Current treatment regimens for symptomatic tumors primarily require surgical intervention. However, a major emphasis of leiomyoma research involves understanding how hormones regulate tumor growth to target the hormonal dependence of these tumors with new therapeutic strategies. Gonadotropin-releasing hormone agonists that block hormone production and induce a hypoestrogenic milieu can be utilized as adjuvant therapy; however, these drugs do little to reduce tumor cellularity, and their negative impact on bone mineral density limits their use. Selective estrogen receptor modulators (SERMs) are nonsteroidal therapeutic agents that bind to the estrogen receptor and elicit tissue-specific estrogen agonist or antagonist effects. SERMs are effective in the treatment and prevention of breast cancer, and preclinical and clinical data suggest that these hormonal modulators may also be beneficial for the treatment of uterine leiomyomas. Continued efforts to understand the role of hormones in the development of this disease will allow the development of newer, less invasive treatment strategies, which will help minimize the negative impact of these tumors on women's health.
Cook
Jennifer D
JD
Department of Carcinogenesis, University of Texas, M.D. Anderson Cancer Center, Smithville, Texas 78957, USA.
Walker
Cheryl Lyn
CL
D004967:Estrogens / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006728:Hormones / Q000502:physiology*; D006801:Humans; D007889:Leiomyoma / Q000188:drug therapy*; D011374:Progesterone / Q000502:physiology; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D014594:Uterine Neoplasms / Q000188:drug therapy*
D004967:Estrogens; D006728:Hormones; D020845:Selective Estrogen Receptor Modulators; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone