Lipid rafts: microenvironments for integrin-growth factor interactions in neural development.
The development of a complex multicellular organ such as the nervous system requires precise regulation of cell migration, proliferation and survival. This regulation in turn requires the integration of long-range signals, such as growth factors, with short-range cues that define the precise location and cellular neighbours for any given cell. This short review examines one integrative mechanism, integrin-growth factor receptor interactions, and explores the role of lipid rafts in the molecular mechanisms that underlie the receptor interactions.
Decker
L
L
Department of Pathology, Cambridge Centre for Brain Repair, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Baron
W
W
Ffrench-Constant
C
C
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D006133:Growth Substances / Q000737:chemistry*; D006801:Humans; D016023:Integrins / Q000737:chemistry*; D021962:Membrane Microdomains / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D011485:Protein Binding; D015398:Signal Transduction
D006133:Growth Substances; D016023:Integrins; D010982:Platelet-Derived Growth Factor