[The use of nebivolol for the treatment of hypertension in patients with osteoarthrosis].
Nebivolol (5 mg/day) was given for 3 months to 20 patients with essential hypertension and osteoarthrosis treated with diclofenac and to 20 other patients with essential hypertension. After 3 months lowering of blood pressure, decreases of components of 24-hour blood pressure profile, improvements of signs of left ventricular hypertrophy occurred in both groups. There were no significant differences between changes of parameters studied between 2 groups. Thus diclofenac (nonselective cyclooxygenase inhibitor) did not attenuate antihypertensive effect of nebivolol and its action on left ventricular hypertrophy.
Mazurov
V I
VI
St-Petersburg Medical Academy of Postgraduate Medical Education; ul Kirochnaya 41, 193015 St-Petersburg, Russia.
Rassokhin
V V
VV
Shostak
M S
MS
D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D000068577:Nebivolol; D010003:Osteoarthritis
D000959:Antihypertensive Agents; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol