title: Efficacy of topical treatment with aescin + essential phospholipids gel on capillary fragility.
abstract: The aim of this efficacy study was to evaluate local capillary fragility with the vacuum suction chamber (VSC) in patients with chronic venous hypertension due to chronic venous disease. All included patients had important ankle edema due to venous hypertension because of a post-thrombotic syndrome. Severe, deep, venous incompetence was present. The VSC was applied onto the internal perimalleolar region. Negative pressure was applied for a variable period of 2, 4, 6, 8, and 10 minutes. The negative pressure in the plastic chamber (2 cm in diameter)-as previously described-was 50 mm Hg. A group of ten patients (mean age 56 years; SD 4; M:F = 5:5) were studied. The tests were repeated in steps of two tests on different days. Between the two tests, with the VSC applied in different skin areas of the perimalleolar region, an interval of at least 30 minutes was observed.
authors.affiliation: Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: A
authors.initials: A
authors.lastname: Di Renzo
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: M
authors.initials: M
authors.lastname: Dugall
mesh_terms: D000287:Administration, Topical; D002198:Capillary Fragility / Q000187:drug effects*; D002908:Chronic Disease; D004338:Drug Combinations; D004928:Escin / Q000008:administration & dosage*; D005260:Female; D005782:Gels; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D012867:Skin / Q000098:blood supply*; D014689:Venous Insufficiency / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D004338:Drug Combinations; D005782:Gels; D010713:Phosphatidylcholines; C011246:essential 303 forte; D004928:Escin