Comparison of carboxyterminal telopeptide of type I collagen (ICTP) and CA 125 as predictors of prognosis in ovarian cancer.
BACKGROUND
The clinical significance of the carboxyterminal telopeptide of type I (ICTP) as a predictor of prognosis is insufficiently known in ovarian cancer. Therefore, we compared the prognostic accuracy of ICTP and CA 125 and their combination with each other and with the aminoterminal propeptide of type III procollagen (PIIINP) and clinical prognosticators.


METHODS
Fifty-five epithelial ovarian cancer patients treated in Oulu University Hospital, Finland, from 1989-1995, were enrolled in this study. Cytoreduction was performed as completely as possible. The preoperative serum concentrations of the biochemical markers were determined using commercial kits.


RESULTS
In univariate analysis, each biochemical marker and all conventional prognostic indicators, with the exception of histological subtype, correlated significantly with survival. In multivariate Cox analysis on biochemical and clinical markers, ICTP alone and ICTP + CA 125, but not CA 125 alone, proved useful indicators of overall survival. The combination of ICTP and CA 125, however, added no essential information compared to that obtained with ICTP alone.


CONCLUSIONS
The ICTP test seems to be a clinically useful predictor of the clinical behavior of ovarian cancer. An increased serum ICTP concentration may reflect the spreading and aggressiveness of invasively growing ovarian cancer.
Santala
Markku
M
Department of Obstetrics and Gynecology, University of Oulu, Finland. msantala@cc.oulu.fi
Risteli
Juha
J
Kauppila
Antti
A
D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000097:blood*; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000473:pathology; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood*; D011237:Predictive Value of Tests; D011347:Procollagen / Q000097:blood; D011379:Prognosis
D018394:CA-125 Antigen; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide; D003094:Collagen