title: [Intestinal permeability of patients with advanced digestive tract malignant tumors].
abstract: OBJECTIVE
  To assess the intestinal barrier function of patients with advanced digestive tract malignant tumors by measuring the changes in intestinal permeability.
  
  
  METHODS
  Sixteen patients with digestive tract tumors and 16 healthy volunteers were enrolled. After oral administration of mannitol and lactulose in deionized water, the 6-hour urine samples were collected for analyzing mannitol and lactulose concentrations using gas-liquid chromatography.
  
  
  RESULTS
  Urine lactulose concentration and lactulose/mannitol (L/M) ratio of the tumor patients were increased in comparison with those of the healthy subjects (P<0.05).
  
  
  CONCLUSIONS
  he intestinal permeability increased in these tumor patients, indicating intestinal barrier dysfunction.
authors.affiliation: Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. yaoge1972@163.com
authors.forename: Yu-chuan
authors.initials: YC
authors.lastname: Yao
authors.forename: Cun-long
authors.initials: CL
authors.lastname: Chen
authors.forename: Ji-de
authors.initials: JD
authors.lastname: Wang
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: De-xin
authors.initials: DX
authors.lastname: Xiong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002849:Chromatography, Gas; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007792:Lactulose / Q000652:urine; D008297:Male; D008353:Mannitol / Q000652:urine; D008875:Middle Aged; D010539:Permeability
chemical_list: D008353:Mannitol; D007792:Lactulose