title: Microscopic polyangiitis associated with diffuse panbronchiolitis.
abstract: There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis.
authors.affiliation: Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi.
authors.forename: Jangchul
authors.initials: J
authors.lastname: Park
authors.forename: Shogo
authors.initials: S
authors.lastname: Banno
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Kosho
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Taio
authors.initials: T
authors.lastname: Naniwa
authors.forename: Kaori
authors.initials: K
authors.lastname: Wakita
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Hayami
authors.forename: Shigeki
authors.initials: S
authors.lastname: Sato
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ueda
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001988:Bronchiolitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D002772:Cholera Toxin; D005260:Female; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase; D011859:Radiography; D014657:Vasculitis / Q000150:complications*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D002772:Cholera Toxin; D009195:Peroxidase