The role of the fibrinolytic system in corneal angiogenesis.
The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins involved in the regulation of fibrinolysis during corneal angiogenesis, we have studied corneal vessel formation in mice deficient for urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), plasminogen, plasminogen activator inhibitor-1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI). Our results corroborate earlier findings that angiogenesis in the mouse cornea is dependent on PAI-1 and plasminogen. The absence of tPA, uPA or TAFI did not affect the formation of new vessels in the cornea.
Vogten
J Mathijs
JM
Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Reijerkerk
Arie
A
Meijers
Joost C M
JC
Voest
Emile E
EE
Borel Rinkes
Inne H M
IH
Gebbink
Martijn F B G
MF
D000818:Animals; D025901:Carboxypeptidase B2 / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D003315:Cornea / Q000098:blood supply* / Q000378:metabolism*; D005342:Fibrinolysis; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010958:Plasminogen / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D010960:Plasminogen Activators / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology* / Q000502:physiology; D010959:Tissue Plasminogen Activator / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology
D017395:Plasminogen Activator Inhibitor 1; D016222:Fibroblast Growth Factor 2; D010958:Plasminogen; D025901:Carboxypeptidase B2; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator