title: Nonalcoholic steatohepatitis with improved hepatic fibrosis after weight reduction.
abstract: A 65-year-old woman was admitted to our hospital for an investigation of liver dysfunction. She had mild obesity with hyperlipidemia, but no history of alcohol abuse. Other known causes of liver dysfunction, such as viruses, autoimmunity and drug effects, were excluded. The liver histology was consistent with nonalcoholic steatohepatitis (NASH). After diagnosis of NASH, the patient started diet and exercise therapy and, in parallel with weight reduction, her liver function improved. One year after the therapy, a liver biopsy showed that steatosis, necroinflammation and even fibrosis were improved. Hence, here we report a case of NASH in which weight reduction was effective in improving both biochemical and histological findings.
authors.affiliation: First Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki.
authors.forename: Keita
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ohata
authors.forename: Takuya
authors.initials: T
authors.lastname: Honda
authors.forename: Seiji
authors.initials: S
authors.lastname: Miyazoe
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hamasaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Kan
authors.initials: K
authors.lastname: Toriyama
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D000368:Aged; D001706:Biopsy; D005081:Exercise Therapy; D005234:Fatty Liver / Q000473:pathology / Q000628:therapy*; D005260:Female; D006505:Hepatitis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications*; D015431:Weight Loss