title: Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after immunologic response to antiretroviral therapy.
abstract: We performed a prospective observational study to assess the safety of stopping maintenance therapy for disseminated histoplasmosis among human immunodeficiency virus infected patients after response to antiretroviral therapy. All subjects received at least 12 months of antifungal therapy and 6 months of antiretroviral therapy before entry. Negative results of fungal blood cultures, urine and serum Histoplasma antigen level of <4.1 units, and CD4+ T cell count of >150 cells/mm3 were required for eligibility. Thirty-two subjects were enrolled; the median CD4+ T cell count at study entry was 289 cells/mm3. No relapses of histoplasmosis occurred after a median duration of follow-up of 24 months. This corresponded to an observed relapse rate of 0 cases per 65 person-years. The median CD4+ T cell count at final study visit was 338 cells/mm3. Discontinuation of antifungal maintenance therapy appears to be safe for patients with acquired immunodeficiency syndrome with previously treated disseminated histoplasmosis and sustained immunologic improvement in response to antiretroviral therapy.
authors.affiliation: Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, Indiana 46202, USA. mgoldman@iupui.edu
authors.forename: Mitchell
authors.initials: M
authors.lastname: Goldman
authors.forename: Robert
authors.initials: R
authors.lastname: Zackin
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Fichtenbaum
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Skiest
authors.forename: Susan L
authors.initials: SL
authors.lastname: Koletar
authors.forename: Richard
authors.initials: R
authors.lastname: Hafner
authors.forename: L Joseph
authors.initials: LJ
authors.lastname: Wheat
authors.forename: Peter M
authors.initials: PM
authors.lastname: Nyangweso
authors.forename: Constantin T
authors.initials: CT
authors.lastname: Yiannoutsos
authors.forename: Carol T
authors.initials: CT
authors.lastname: Schnizlein-Bick
authors.forename: Susan
authors.initials: S
authors.lastname: Owens
authors.forename: Judith A
authors.initials: JA
authors.lastname: Aberg
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology / Q000517:prevention & control; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology; D006658:Histoplasma / Q000276:immunology*; D006660:Histoplasmosis / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000378:metabolism
chemical_list: D019380:Anti-HIV Agents; D000935:Antifungal Agents; D012367:RNA, Viral