title: [Effect of novel natural hypolipidemic compounds on human immunodeficiency virus].
abstract: Target screening among microbial products resulted in isolation of hypolipidemic compounds tested for activity against HIV in culture of transferable lymphoblastoid cells MT-4. The majority of the compounds showed antiviral activity. The highest antiviral effect was observed when before exposure to the virus the cells were preincubated for 1 hour in the presence of the isolated compounds. The compounds showed no effect when added to the cell culture preliminarily infected by HIV.
authors.affiliation: National Research Centre of Antibiotics, Moscow, D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow.
authors.forename: M V
authors.initials: MV
authors.lastname: Bibikova
authors.forename: D N
authors.initials: DN
authors.lastname: Nosik
authors.forename: O A
authors.initials: OA
authors.lastname: Lobych
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Chmel'
authors.forename: A V
authors.initials: AV
authors.lastname: Katlinskiĭ
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D000960:Hypolipidemic Agents