Prostate brachytherapy can be performed in selected patients after transurethral resection of the prostate.
OBJECTIVE
To evaluate urinary function and bother after prostate brachytherapy (PB) in patients who have had prior transurethral resection of the prostate (TURP).


METHODS
A total of 171 patients with stage T1a-T2b prostate cancer, Gleason score <or=7 who underwent prior TURP received PB at a single institution. In January 2002, all 171 patients were mailed the University of California-Los Angeles Prostate Cancer Index and International Prostate Symptom Score sheet. One hundred patients (60%) returned completed surveys. Time of TURP before implant ranged from 2 to 300 months (median, 6.5 years). Mean patient age was 74 +/- 5.2 years, follow-up time after implant ranged from 6.1 to 50.9 months (median, 25 months).


RESULTS
The mean urinary function score and bother score for the entire study group was 83.5 +/- 19.5 and 82.5 +/- 23.7, respectively. Multivariate analysis revealed higher pretreatment International Prostate Symptom Scores to have significant negative impact (p = 0.001) on urinary function and bother scores.


CONCLUSIONS
With accurate ultrasound identification of the urethral defect and precise dosimetry, brachytherapy can be performed in selected patients who have had prior TURP with resultant low impact on urinary function and bother scores.
Moran
Brian J
BJ
Chicago Prostate Cancer Center, Westmont, IL 60559, USA. seeds@prostateimplant.com
Stutz
Michael A
MA
Gurel
Michelle H
MH
D000368:Aged; D000704:Analysis of Variance; D001918:Brachytherapy / Q000379:methods; D003131:Combined Modality Therapy; D000075202:Contraindications; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D020728:Transurethral Resection of Prostate; D018084:Ultrasonography, Interventional; D014554:Urination; D014555:Urination Disorders / Q000453:epidemiology