Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing.
Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels. Mammalian degenerin homologues, the H(+)-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.
Roza
Carolina
C
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.
Puel
Jean-Luc
JL
Kress
Michaela
M
Baron
Anne
A
Diochot
Sylvie
S
Lazdunski
Michel
M
Waldmann
Rainer
R
D062565:Acid Sensing Ion Channels; D000818:Animals; D001309:Auditory Threshold; D017353:Gene Deletion; D006309:Hearing / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D009865:Oocytes / Q000502:physiology; D018408:Patch-Clamp Techniques; D017434:Protein Structure, Tertiary; D012867:Skin / Q000294:innervation; D015222:Sodium Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D017833:Visceral Afferents / Q000502:physiology; D014982:Xenopus laevis
C568265:ASIC2 protein, mouse; D062565:Acid Sensing Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D015222:Sodium Channels