Lack of association of interleukin-1beta polymorphism with Alzheimer's disease in the Jewish population.
A growing body of evidence suggests that Alzheimer's disease (AD) is associated with local inflammation processes, including the activation of inflammatory cytokines. We performed a case-control association study between sporadic AD patients and the exon 5 position +3953 polymorphism in the potent pro-inflammatory cytokine, interleukin-1beta (IL-1B). Recent association studies of this locus with AD revealed conflicting results, suggesting that the association - if it exists - is not universal but rather population specific. In our study no association was detected with AD: neither as a risk factor nor as a modifier gene affecting the age at onset and disease progression. These findings show no evidence for an association between the IL-1B +3953 polymorphism and AD in the Jewish population.
Rosenmann
Hanna
H
The Agnes Ginges Center for Human Neurogenetics, Department of Neurology, Hadassah University Hospital, Jerusalem, Israel. rosenman@hadassah.org.il
Meiner
Zeev
Z
Dresner-Pollak
Rivka
R
Kahana
Esther
E
Aladjem
Zoja
Z
Grenader
Tal
T
Wertman
Eli
E
Abramsky
Oded
O
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics* / Q000276:immunology; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D018450:Disease Progression; D004660:Encephalitis / Q000235:genetics / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D007585:Jews; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D007375:Interleukin-1