Blood rheological characterization using the thickness-shear mode resonator.
Thickness-shear mode (TSM) resonators have been used to characterize static rheological properties of plasma and whole blood samples. We demonstrated simple and rapid techniques for determining plasma viscosity without cell separation, for measuring erythrocyte sedimentation rate, and for tracking blood coagulation throughout the entire process. Additionally, mathematical models, previously developed to characterize surface-loaded resonators, were used to extract non-Newtonian and viscoelastic material properties of blood layers during sedimentation and coagulation experiments. These studies indicate the utility of the TSM resonator for several clinical applications. Because the resonators can be miniaturized, potential exists for extending the techniques for use inside the body or blood stream (in vivo).
Bandey
Helen L
HL
Microsensor Research and Development Department, Sandia National Laboratories, Albuquerque, NM 87185-1425, USA.
Cernosek
Richard W
RW
Lee
William E
WE
Ondrovic
Leo E
LE
D000465:Algorithms; D001780:Blood Coagulation Tests / Q000295:instrumentation* / Q000379:methods; D001790:Blood Physiological Phenomena; D001799:Blood Sedimentation; D001809:Blood Viscosity; D003198:Computer Simulation; D004548:Elasticity; D004867:Equipment Design; D019544:Equipment Failure Analysis; D018056:Hemorheology / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D033081:Shear Strength; D013696:Temperature; D014159:Transducers; D014783:Viscosity