[Advances in the research of sperm protein 17].
Sperm protein 17 (Sp17) is a testis-specific protein involved in acrosome reaction in spermatozoa. However, the Sp17 gene has been recently detected in normal non-testis tissues and malignant neoplasias. Therefore Sp17 may be a potential target for immunocontraception and a suitable target for tumor immunotherapy. This paper reviews the advances in the protein characterization, expression and distribution, and biological function of Sp17 and its clinical research.
Zhang
Ling
L
Center of Medical Laboratory Science of PLA, Nanjing General Hospital of Nanjing Command, Nanjing, Jiangsu 210002, China.
Li
Fangqiu
F
D000818:Animals; D000954:Antigens, Surface; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins / Q000032:analysis / Q000502:physiology*; D003269:Contraception, Immunologic; D006801:Humans; D007167:Immunotherapy; D008297:Male; D008565:Membrane Proteins
D000954:Antigens, Surface; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; C090172:SPA17 protein, human