title: [The role of matrix metal proteinases in the development of restenoses after transcutaneous coronary interventions].
abstract: Endovascular coronary interventions for CAD induce restenoses in 20-50% of patients after 3-6 months. Following angioplasty or stenting restenosis arises from constrictive remodeling of the arterial wall and intimal hyperplasia. The damaged arteries provoke migration and proliferation of smooth muscle cells as a result of which there forms the neointima with accumulation of the extracellular matrix in the arterial intimal layer. These processes are regulated by matrix metal proteinases (MMP) and their tissue inhibitors. The rise of the MMP level in the dilated coronary arteries leads to vascular remodeling and formation of restenosis due to the effect on vascular smooth cell migration and thrombosis.
authors.forename: O A
authors.initials: OA
authors.lastname: Zemlianskaia
mesh_terms: D000800:Angioplasty, Balloon; D023903:Coronary Restenosis / Q000378:metabolism*; D023921:Coronary Stenosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D020782:Matrix Metalloproteinases / Q000378:metabolism / Q000502:physiology*; D017539:Tunica Intima / Q000473:pathology
chemical_list: D020782:Matrix Metalloproteinases