title: [Effects of Shenshuai Yangzhen capsule on lipid metabolism disorder in rats with chronic renal failure].
abstract: OBJECTIVE
  To investigate the therapeutic effect of Shenshuai Yangzhen capsule, a preparation of traditional Chinese medicine, on lipid metabolism disorder in rats with chronic renal failure (CRF) and explore its mechanism.
  
  
  METHODS
  Fifty male SD rats received 5/6 nephrectomy for preparation of CRF models and were randomized into CRF group, gemfibrozil group, high-, moderate- and low-dose Shenshuai Yangzhen groups, and normal control group. After 4-week treatment as indicated, myocardial lipoprotein lipase messenger RNA (LPL mRNA) level were measured by RT-PCR in rats with surgically induced renal failure (two-stage subtotal nephrectomy). The blood lipid parameters in CRF rats were also determined.
  
  
  RESULTS
  Compared with those in the CRF group, the plasma total cholesterol, triglyceride, low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol concentrations in the treatment groups were significantly lower with substantially elevated plasma high-density lipoprotein cholesterol and LPL gene expression. No significant differences were noted between different dose groups of Shenshuai Yangzhen.
  
  
  CONCLUSIONS
  Shenshuai Yangzhen capsule can regulate blood lipid levels in rats with renal insufficiency possibly by enhancing LPL gene expression.
authors.affiliation: Department of Traditional Chinese Medicine, Zhujiang Hospital, First Military Medical University, Guangzhou 510515, China. lymfeng@163.net
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Li
authors.forename: Lian-bo
authors.initials: LB
authors.lastname: Wei
authors.forename: Gang
authors.initials: G
authors.lastname: Yuan
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Ma
authors.forename: Lin
authors.initials: L
authors.lastname: Huang
mesh_terms: D000818:Animals; D002214:Capsules; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics; D008297:Male; D009206:Myocardium / Q000201:enzymology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D008055:Lipids; D012333:RNA, Messenger; D008071:Lipoprotein Lipase