title: Arterio-embolic ischemic stroke in children with moyamoya disease.
abstract: BACKGROUND
  Moyamoya (MM) disease is a rare steno-occlusive cerebrovascular disease known to occur in children and adults. The most serious complications in children are developmental delay and mental retardation due to recurrent hemodynamic stroke.
  
  
  METHODS
  We report two pediatric patients without coagulopathy who suffered from severe arterio-embolic ischemic complications despite antiplatelet medication.
  
  
  CONCLUSIONS
  These observations underline the potential impact of cerebral thromboembolism on the pathophysiology of the stroke and thus on the treatment of children with MM disease.
authors.affiliation: Department of Neurosurgery, Universitätsklinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. peter.horn@nch.ma.uni-heidelberg.de
authors.forename: Peter
authors.initials: P
authors.lastname: Horn
authors.forename: Eva
authors.initials: E
authors.lastname: Bueltmann
authors.forename: Christoph V
authors.initials: CV
authors.lastname: Buch
authors.forename: Peter
authors.initials: P
authors.lastname: Schmiedek
mesh_terms: D020771:Anterior Cerebral Artery / Q000473:pathology* / Q000503:physiopathology; D002533:Cerebral Angiography / Q000379:methods; D002648:Child; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008297:Male; D009072:Moyamoya Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D020521:Stroke / Q000209:etiology* / Q000473:pathology