title: Multiple hepatic peribiliary cysts with cirrhosis.
abstract: Multiple hepatic peribiliary cysts were found in three autopsy cases of patients who had had underlying liver diseases and obstructive jaundice. Macroscopically, the cysts were visible and present exclusively in the hepatic hilum and larger portal tracts. Histologically, the cysts were of varying size and were lined by a single layer of cuboidal or flattened epithelial cells without atypia. Intimate association between the cysts and peribiliary glands was found in the walls of large bile ducts. All three cases were associated with liver cirrhosis in patients with portal hypertension, and two of the patients had also had hepatocellular carcinoma. These findings support the previous assumption that multiple hepatic peribiliary cysts may be closely related to a portal hypertensive condition. Although peribiliary cysts have been considered to be clinically asymptomatic in general, in one of our patients, the cystic dilatation appeared to have been responsible for the progression of obstructive jaundice.
authors.affiliation: Second Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Seguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Akiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Seiji
authors.initials: S
authors.lastname: Naganuma
authors.forename: Koki
authors.initials: K
authors.lastname: Nagaike
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kataoka
mesh_terms: D000368:Aged; D001344:Autopsy; D001649:Bile Duct Diseases / Q000150:complications* / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000473:pathology; D003560:Cysts / Q000150:complications* / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications / Q000473:pathology; D041781:Jaundice, Obstructive / Q000209:etiology / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male