[Vitamin E and apoptosis].
The literature data concerning the participation of tocopherol in apoptosis are discussed. Acting as antioxidant this vitamin exerts a complex effect on apoptosis mechanisms. Its action on this process is caused by involvement of some different mechanisms transducing the apoptotic signal. Among them are caspase and Fas-receptor activation, sphingosine metabolism, processes carried out in nuclei and mitochondria and signal transduction pathways. The specific mechanisms connected with interaction of this vitamin with tocopherol-binding proteins may be also involved in this vitamin action.
Petrova
G V
GV
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine. petrova@biochem.kiev.ua
Kapralov
A A
AA
Donchenko
G V
GV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000502:physiology; D017209:Apoptosis / Q000187:drug effects*; D020013:Calcium Signaling / Q000187:drug effects; D015290:Second Messenger Systems / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology* / Q000502:physiology
D000975:Antioxidants; D014810:Vitamin E