Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger.
The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 degrees C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l(-1)) to 15-hydroxy-10-deoxoartemisinin (26%) and 7beta-hydroxy-10-deoxoartemisinin (69%).
Parshikov
Igor A
IA
Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.
Miriyala
Bruhaspathy
B
Avery
Mitchell A
MA
Williamson
John S
JS
D037621:Artemisinins / Q000378:metabolism*; D001234:Aspergillus niger / Q000378:metabolism*; D018929:Cell Culture Techniques / Q000379:methods; D006900:Hydroxylation; D008968:Molecular Conformation; D008970:Molecular Weight; D012717:Sesquiterpenes / Q000378:metabolism*
C495441:15-hydroxy-10-deoxoartemisinin; D037621:Artemisinins; D012717:Sesquiterpenes; C063801:deoxoartemisinin