title: Fitness cost of SCCmec and methicillin resistance levels in Staphylococcus aureus.
abstract: Transformation of a type I SCCmec element into Staphylococcus aureus yielded highly oxacillin-resistant transformants with a reduced growth rate. Faster-growing variants could again be selected at the cost of reduced resistance levels, demonstrating an inverse correlation between oxacillin resistance levels and growth rate.
authors.affiliation: Department of Medical Microbiology, University of Zürich, Gloriastr. 32, CH8028 Zürich, Switzerland.
authors.forename: Miriam
authors.initials: M
authors.lastname: Ender
authors.forename: Nadine
authors.initials: N
authors.lastname: McCallum
authors.forename: Rajan
authors.initials: R
authors.lastname: Adhikari
authors.forename: Brigitte
authors.initials: B
authors.lastname: Berger-Bächi
mesh_terms: D015169:Colony Count, Microbial; D015257:DNA-Cytosine Methylases / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D020071:Interspersed Repetitive Sequences / Q000235:genetics; D016106:Methicillin Resistance / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010957:Plasmids / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development*; D014169:Transformation, Bacterial / Q000235:genetics
chemical_list: D010406:Penicillins; C079006:DNA modification methylase XcyI; D015257:DNA-Cytosine Methylases; D010068:Oxacillin