title: [Preparation of all-trans retinoic acid mixed micelles injection].
abstract: OBJECTIVE
  To increase the solubility and bioavailability of all-trans retinoic acid (ATRA).
  
  
  METHODS
  Using the principle of lecthin/bile salt mixed micelle to prepared ATRA injection. The best formulation was obtained by the turbidity and three-phase figure.
  
  
  RESULTS
  ATRA mixed micelles injection is stable. The average size of the mixed micelle is 17.8 nm, poly. index 0.495, zeta potential -16.5 mV.
  
  
  CONCLUSIONS
  The method can be used to prepare the stable injection.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. kfzl@hotmail.com
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Jia-bi
authors.initials: JB
authors.lastname: Zhu
authors.forename: Ying
authors.initials: Y
authors.lastname: Tu
authors.forename: Xu
authors.initials: X
authors.lastname: Tian
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001647:Bile Acids and Salts; D004355:Drug Stability; D008823:Micelles; D010713:Phosphatidylcholines; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014212:Tretinoin / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001647:Bile Acids and Salts; D008823:Micelles; D010713:Phosphatidylcholines; D014212:Tretinoin