[Tumor redifferentiation in papillary thyroid carcinoma alter retinoic acid administration].
Male patient, 73 year old, with papillary thyroid carcinoma treated by surgery, 131I and L-Tyroxine, with bone metastasis, detected by bone scintigraphy and CT scan, which negative radioiodine uptake. In order to induce tumoral redifferentiation, retinoic acid (70 mg/day) was administered for three months before 131I treatment. A radioiodine scan performed after treatment showed uptake in some of the bone metastasis. Nine months later, and due to disease progression, a second induction with retinoic acid was performed before 131I treatment. The radioiodine scan performed after treatment showed greater uptake and higher number of bone lesions than the previous scan.
Camacho Martí
V
V
Departamento de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. mcamachom@hsp.santpau.es
Estorch Cabrera
M
M
Mena González
E
E
Fuertes Manuel
J
J
Hernández Fructuoso
M A
MA
Flotats Giralt
A
A
Carrió Gasset
I
I
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000556:secondary; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D014212:Tretinoin / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014212:Tretinoin