Intratumoral hypoxia, radiation resistance, and HIF-1.
Failure to achieve complete remission after radiation therapy is a predictor of patient mortality, and hypoxic cancer cells are more likely to survive radiation therapy. Recent studies have shown that radiation-induced endothelial cell death results in secondary tumor cell killing. In this issue of Cancer Cell, now provide evidence that radiation induces HIF-1-mediated expression of VEGF and bFGF in tumor cells, which promotes endothelial cell survival.
Semenza
Gregg L
GL
Program in Vascular Cell Engineering, The Johns Hopkins University School of Medicine, 733 North Broadway, Suite 671, Baltimore, MD 21205, USA. gsemenza@jhmi.edu
D000818:Animals; D015687:Cell Hypoxia; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000528:radiation effects; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D011836:Radiation Tolerance; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2