Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm.
BACKGROUND
Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria.


OBJECTIVE
In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus.


RESULTS
The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05).


CONCLUSIONS
Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.
Steinberg
Doron
D
Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel. dorons@cc.huji.ac.il
Feldman
Mark
M
Ofek
Itzhak
I
Weiss
Ervin I
EI
D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects*; D003956:Dialysis; D004305:Dose-Response Relationship, Drug; D017886:Durapatite; D005964:Glucosyltransferases / Q000378:metabolism; D006602:Hexosyltransferases / Q000378:metabolism; D008970:Molecular Weight; D013295:Streptococcus mutans / Q000187:drug effects*; D016986:Streptococcus sobrinus / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology; D014070:Tooth / Q000382:microbiology*; D029799:Vaccinium macrocarpon / Q000737:chemistry*; D001426:Bacterial Proteins
D017886:Durapatite; D005964:Glucosyltransferases; D006602:Hexosyltransferases; D013395:Sucrose; C021451:inulosucrase; D001426:Bacterial Proteins