title: A study on perchlorate exposure and absorption in beef cattle.
abstract: Perchlorate exposure and potential effects were evaluated in large mammals by monitoring heifer calves placed on a site with access to streamwater fed by a perchlorate-contaminated groundwater spring ( approximately 25 ng/mL). Blood was collected from the two calves on the site (and two control calves from an uncontaminated site) approximately every 2 weeks for analysis of perchlorate residues and thyroid hormones. During the 14 week study, perchlorate was detected (detection limit = 13.7 ng/mL) in blood plasma twice (15 ng/mL and 22 ng/mL) in one of the heifer calves drinking perchlorate-contaminated water on consecutive sampling periods 4 and 6 weeks after the beginning of perchlorate exposure. Constant exposure to 25 ppb perchlorate in drinking water had no effect on circulating thyroid hormones (T(3) and T(4)) in the heifer calves.
authors.affiliation: Departments of Environmental Toxicology and Civil Engineering, The Institute of Environmental and Human Health (TIEHH), Texas Tech University, Lubbock, Texas 79409-1163, USA.
authors.forename: Qiuqiong
authors.initials: Q
authors.lastname: Cheng
authors.forename: Lisa
authors.initials: L
authors.lastname: Perlmutter
authors.forename: Philip N
authors.initials: PN
authors.lastname: Smith
authors.forename: Scott T
authors.initials: ST
authors.lastname: McMurry
authors.forename: William A
authors.initials: WA
authors.lastname: Jackson
authors.forename: Todd A
authors.initials: TA
authors.lastname: Anderson
mesh_terms: D000042:Absorption; D000818:Animals; D002417:Cattle; D004781:Environmental Exposure; D010472:Perchlorates / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D017670:Sodium Compounds / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014873:Water Pollutants / Q000493:pharmacokinetics* / Q000633:toxicity*
chemical_list: D010472:Perchlorates; D017670:Sodium Compounds; D014873:Water Pollutants; D014284:Triiodothyronine; C031068:sodium perchlorate; D013974:Thyroxine