title: A comparison of anterior and posterior chamber lenses after cataract extraction in rural Africa: a within patient randomised trial.
abstract: BACKGROUND
  Extracapsular cataract extraction (ECCE) with a posterior chamber intraocular lens (PC IOL) is the preferred method of cataract surgery in developed countries. However, intracapsular cataract extraction (ICCE) with an anterior chamber lens (AC IOL) may be appropriate in rural Africa. A randomised controlled trial was carried out to compare these surgical strategies.
  
  
  METHODS
  Participants over 50 years requiring bilateral cataract surgery were recruited from outreach clinics in rural north and east Uganda. One eye was randomly allocated to AC IOL or PC IOL, the other eye being allocated to the second strategy. The main outcome measure was WHO distance visual acuity (VA) category after a minimum of 1 year. Secondary outcomes were numbers and causes of complications and refractive corrections.
  
  
  RESULTS
  Of the 110 participants recruited, 98 (89%) were assessed at least 1 year after the operation (median follow up 17.5 months). Nine eyes randomised to PC IOL were converted to AC IOL; one eye randomised to AC IOL inadvertently received PC IOL. There was no difference in VA between 95 pairs of eyes for which data for both eyes were available (uncorrected VA, p = 0.26; corrected VA, p = 0.59). 80 (82%, 95% CI 73 to 89) and 82 (84%, 95% CI 75 to 90) eyes randomised to AC IOL and PC IOL respectively had corrected VA of 6/18 or better. 16 (16%, 95% CI 10 to 25) and eight (8%, 95% CI 4 to 15) eyes respectively had secondary procedures or other complications.
  
  
  CONCLUSIONS
  Where both strategies are available, ECCE with PC IOL should be first choice because of fewer complications. Where ECCE with PC IOL is not immediately feasible, ICCE with AC IOL is an acceptable interim technique.
authors.affiliation: Ruharo Eye Hospital, Mbarara, PO Box 4008, Kampala, Uganda.
authors.forename: K M
authors.initials: KM
authors.lastname: Waddell
authors.forename: B C
authors.initials: BC
authors.lastname: Reeves
authors.forename: G J
authors.initials: GJ
authors.lastname: Johnson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D003906:Developing Countries; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000379:methods*; D007910:Lenses, Intraocular; D008875:Middle Aged; D019035:Rural Health Services; D016896:Treatment Outcome; D014454:Uganda; D014792:Visual Acuity