title: [Experimental study on the in vitro resistance to Toxoplasma gondii by murine lymphocyte].
abstract: OBJECTIVE
  To study the activities of in vitro resistance to the tachyzoite of Toxoplasma gondii by murine lymphocytes.
  
  
  METHODS
  The rat's splenocyte culture method was used to observe the effects of lymphocytes themselves and lymphocytes together with Mandelic( MA) on the invasion and proliferation of T. gondii in lymphocytes. At the same time acetylspiramycin was used as positive control.
  
  
  RESULTS
  As compared with other somatic cells, the lymphocytes invaded by T. gondii still inhibited and killed the toxoplasma organisms in the presence of immunity, the effect safety dose of MA on inhibition of the invasion of T. gondii was not notable while the inhibition of the proliferation of T. gondii in lymphocytes was remarkable.
  
  
  CONCLUSIONS
  Cell-mediated immunity(CMI) was an important factor that host resists the T. gondii infection. So, we should pay attention to improving the organism's CMI and take proper medicine so as to enhance the effect of lymphocyte's resistance to T. gondii.
authors.affiliation: Department of Immunology, Medical College of Xi'an Jiaotong University, Xi'an 710061, China. huaxz76@sohu.com
authors.forename: Qi
authors.initials: Q
authors.lastname: Shi
authors.forename: Bing-hua
authors.initials: BH
authors.lastname: Hao
authors.forename: Yu-ling
authors.initials: YL
authors.lastname: Zhou
authors.forename: Xing-min
authors.initials: XM
authors.lastname: Shi
authors.forename: An-ning
authors.initials: AN
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Yan-bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000276:immunology*; D008333:Mandelic Acids / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D015572:Spiramycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014122:Toxoplasma / Q000187:drug effects / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology
chemical_list: D008333:Mandelic Acids; C033163:acetylspiramycin; D015572:Spiramycin; C037938:mandelic acid