Learning of sensory sequences in cerebellar patients.
A possible role of the cerebellum in detecting and recognizing event sequences has been proposed. The present study sought to determine whether patients with cerebellar lesions are impaired in the acquisition and discrimination of sequences of sensory stimuli of different modalities. A group of 26 cerebellar patients and 26 controls matched for age, sex, handedness, musicality, and level of education were tested. Auditory and visual sensory sequences were presented out of different sensory pattern categories (tones with different acoustic frequencies and durations, visual stimuli with different spatial locations and colors, sequential vision of irregular shapes) and different ranges of inter-cue time intervals (fast and slow). Motor requirements were small, with vocal responses and no time restrictions. Perception of visual and acoustic stimuli was generally preserved in patients and controls. The number of errors was significantly higher in the faster tempo of sequence presentation in learning of sequences of tones of different frequencies and in learning of sequences of visual stimuli of different spatial locations and different colors. No difference in tempo between the groups was shown. The total number of errors between the two groups was identical in the sequence conditions. No major disturbances in acquisition or discrimination of various sensory sequences were observed in the group of cerebellar patients. Sequence learning may be impaired only in tasks with significant motor demands.
Frings
Markus
M
Department of Neurology, University of Duisburg-Essen, 45122 Essen, Germany. markus.frings@uni-essen.de
Boenisch
Raoul
R
Gerwig
Marcus
M
Diener
Hans-Christoph
HC
Timmann
Dagmar
D
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000368:Aged; D002526:Cerebellar Diseases / Q000503:physiopathology*; D002531:Cerebellum / Q000502:physiology*; D002648:Child; D004193:Discrimination Learning / Q000502:physiology*; D005260:Female; D006801:Humans; D016555:Matched-Pair Analysis; D008875:Middle Aged; D010465:Perception / Q000502:physiology*; D010775:Photic Stimulation; D012016:Reference Values; D012691:Serial Learning / Q000502:physiology*; D013997:Time Factors