title: Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase-thymidylate synthase.
authors.affiliation: Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA.
authors.forename: Alexia A
authors.initials: AA
authors.lastname: Belperron
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Fox
authors.forename: Robert H
authors.initials: RH
authors.lastname: O'Neil
authors.forename: Kimberly A W
authors.initials: KA
authors.lastname: Peaslee
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Horii
authors.forename: Amy C
authors.initials: AC
authors.lastname: Anderson
authors.forename: David J
authors.initials: DJ
authors.lastname: Bzik
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology; D015153:Blotting, Western; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics*; D016254:Mutagenesis, Insertional; D009154:Mutation; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011739:Pyrimethamine / Q000494:pharmacology; D015183:Restriction Mapping; D016415:Sequence Alignment; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000235:genetics*; D013940:Thymidylate Synthase / Q000737:chemistry / Q000235:genetics*; D014122:Toxoplasma / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D014162:Transfection
chemical_list: D000981:Antiprotozoal Agents; D009097:Multienzyme Complexes; C056930:thymidylate synthase-dihydrofolate reductase; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D011739:Pyrimethamine