title: Preparation of alkylation agents for bulged DNA microenvironments.
abstract: A designed molecule with capacity to alkylate DNA bulges has been prepared from readily available starting materials. The spirocyclic template utilized was designed on the basis of established architectures, and equipped with a mustard alkylating group. Preliminary studies confirm alkylation of specific bulged sequences, paving the way for second generation substrates with higher affinity.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
authors.forename: Farid S
authors.initials: FS
authors.lastname: Fouad
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xi
authors.forename: Irving H
authors.initials: IH
authors.lastname: Goldberg
authors.forename: Graham B
authors.initials: GB
authors.lastname: Jones
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000378:metabolism; D001483:Base Sequence / Q000502:physiology; D001665:Binding Sites / Q000502:physiology; D004247:DNA / Q000235:genetics* / Q000378:metabolism*; D009690:Nucleic Acid Conformation
chemical_list: D000477:Alkylating Agents; D004247:DNA