Amiodarone-induced neonatal hypothyroidism: a unique form of transient early-onset hypothyroidism.
Amiodarone is an iodine-rich drug used to treat cardiac dysrhythmias. The structure of amiodarone resembles that of thyroxine, and treatment with amiodarone may alter thyroid function. The effects of antenatal amiodarone use on fetal/neonatal thyroid function have only been addressed in a limited number of patient reports. We describe two cases of transient neonatal hypothyroidism due to in utero amiodarone exposure, followed by a brief review of the available literature.
Lomenick
Jefferson P
JP
Division of Endocrinology, Cincinnati Children's Hospital Medical Center, MLC 7012, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Jackson
Wendy A
WA
Backeljauw
Philippe F
PF
D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003409:Congenital Hypothyroidism; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007231:Infant, Newborn; D011247:Pregnancy; D013610:Tachycardia / Q000188:drug therapy*
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone