title: Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
abstract: The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: R Ian
authors.initials: RI
authors.lastname: Storer
authors.forename: Toshiyasu
authors.initials: T
authors.lastname: Takemoto
authors.forename: Philip S
authors.initials: PS
authors.lastname: Jackson
authors.forename: Dearg S
authors.initials: DS
authors.lastname: Brown
authors.forename: Ian R
authors.initials: IR
authors.lastname: Baxendale
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry; D034261:Epothilones / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D001685:Biological Factors; D034261:Epothilones; D018942:Macrolides; D011108:Polymers; C426624:epothilone C