Molecular design based on 3D pharmacophores. Applications to 5-HT7 receptors.
A definition of a pharmacophore for the 5-HT7 antagonists was carried out by searching the common chemical features of selective antagonists from the literature. A molecular design is described by analyzing the differences between this new pharmacophore and three other 3D serotonin pharmacophores previously described. This comparison led to the synthesis of a new series of potent 5-HT7 antagonists.
Lepailleur
Alban
A
Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, 5 rue Vaubénard, 14032 Caen, France.
Bureau
Ronan
R
Lemaître
Stéphane
S
Dauphin
François
F
Lancelot
Jean-Charles
JC
Contesse
Vincent
V
Lenglet
Sébastien
S
Delarue
Catherine
C
Vaudry
Hubert
H
Rault
Sylvain
S
D008958:Models, Molecular; D011487:Protein Conformation; D011985:Receptors, Serotonin / Q000737:chemistry*
D011985:Receptors, Serotonin; C104425:serotonin 7 receptor