title: Phytochemical and antiinflammatory studies on Terminalia catappa.
abstract: The antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the antiinflammatory activity of T. catappa leaves.
authors.affiliation: Institute of Materia Medica, Nanjing University School of Medicine, Nanjing 210093, PR China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Fan
authors.forename: L Z
authors.initials: LZ
authors.lastname: Xu
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: X H
authors.initials: XH
authors.lastname: Tang
authors.forename: X N
authors.initials: XN
authors.lastname: Zhao
authors.forename: Z X
authors.initials: ZX
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D029766:Terminalia; D013755:Tetradecanoylphorbol Acetate
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate