title: Genetic structure of the purebred domestic dog.
abstract: We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for approximately 30% of genetic variation. Microsatellite genotypes were used to correctly assign 99% of individual dogs to breeds. Phylogenetic analysis separated several breeds with ancient origins from the remaining breeds with modern European origins. We identified four genetic clusters, which predominantly contained breeds with similar geographic origin, morphology, or role in human activities. These results provide a genetic classification of dog breeds and will aid studies of the genetics of phenotypic breed differences.
authors.affiliation: Division of Human Biology, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109-1024, USA.
authors.forename: Heidi G
authors.initials: HG
authors.lastname: Parker
authors.forename: Lisa V
authors.initials: LV
authors.lastname: Kim
authors.forename: Nathan B
authors.initials: NB
authors.lastname: Sutter
authors.forename: Scott
authors.initials: S
authors.lastname: Carlson
authors.forename: Travis D
authors.initials: TD
authors.lastname: Lorentzen
authors.forename: Tiffany B
authors.initials: TB
authors.lastname: Malek
authors.forename: Gary S
authors.initials: GS
authors.lastname: Johnson
authors.forename: Hawkins B
authors.initials: HB
authors.lastname: DeFrance
authors.forename: Elaine A
authors.initials: EA
authors.lastname: Ostrander
authors.forename: Leonid
authors.initials: L
authors.lastname: Kruglyak
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D005075:Biological Evolution; D001947:Breeding; D019295:Computational Biology; D004283:Dog Diseases / Q000235:genetics; D004285:Dogs / Q000145:classification / Q000235:genetics*; D014644:Genetic Variation; D016678:Genome; D005838:Genotype; D018895:Microsatellite Repeats; D010641:Phenotype; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D012984:Software