Reprogramming committed B lineage cells.
It is generally assumed that once a cell commits to a certain lineage it no longer can change its fate. A new study in this issue of Cell provides compelling evidence that committed mature B lineage cells can be reprogrammed to become macrophages.
Murre
Cornelis
C
Divison of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D022762:CCAAT-Enhancer-Binding Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006689:Hodgkin Disease / Q000209:etiology; D006801:Humans; D008264:Macrophages / Q000502:physiology
D022762:CCAAT-Enhancer-Binding Proteins