Posaconazole therapy of disseminated phaeohyphomycosis in a murine model.
Immunocompetent (nu/+) and athymic (nu/nu) BALB/c mice were infected intravenously with Wangiella dermatitidis and treated with posaconazole. Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain.
Graybill
John R
JR
Department of Medicine, Division of Infectious Diseases, Medicine/ID Mail Code 7881, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900, USA.
Najvar
Laura K
LK
Johnson
Elizabeth
E
Bocanegra
Rosie
R
Loebenberg
David
D
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology; D015169:Colony Count, Microbial; D005093:Exophiala; D016867:Immunocompromised Host; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D016019:Survival Analysis; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole