title: Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing.
abstract: Mechanosensitive cation channels are thought to be crucial for different aspects of mechanoperception, such as hearing and touch sensation. In the nematode C. elegans, the degenerins MEC-4 and MEC-10 are involved in mechanosensation and were proposed to form mechanosensitive cation channels. Mammalian degenerin homologues, the H(+)-gated ASIC channels, are expressed in sensory neurones and are therefore interesting candidates for mammalian mechanosensors. We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France.
authors.forename: Carolina
authors.initials: C
authors.lastname: Roza
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Puel
authors.forename: Michaela
authors.initials: M
authors.lastname: Kress
authors.forename: Anne
authors.initials: A
authors.lastname: Baron
authors.forename: Sylvie
authors.initials: S
authors.lastname: Diochot
authors.forename: Michel
authors.initials: M
authors.lastname: Lazdunski
authors.forename: Rainer
authors.initials: R
authors.lastname: Waldmann
mesh_terms: D062565:Acid Sensing Ion Channels; D000818:Animals; D001309:Auditory Threshold; D017353:Gene Deletion; D006309:Hearing / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D009865:Oocytes / Q000502:physiology; D018408:Patch-Clamp Techniques; D017434:Protein Structure, Tertiary; D012867:Skin / Q000294:innervation; D015222:Sodium Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D017833:Visceral Afferents / Q000502:physiology; D014982:Xenopus laevis
chemical_list: C568265:ASIC2 protein, mouse; D062565:Acid Sensing Ion Channels; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D015222:Sodium Channels