Exclusive consolidated memory phases in Drosophila.
Two types of consolidated memory have been described in Drosophila, anesthesia-resistant memory (ARM), a shorter-lived form, and stabilized long-term memory (LTM). Until now, it has been thought that ARM and LTM coexist. On the contrary, we show that LTM formation leads to the extinction of ARM. Flies devoid of mushroom body vertical lobes cannot form LTM, but spaced conditioning can still erase their ARM, resulting in a remarkable situation: The more these flies are trained, the less they remember. We propose that ARM acts as a gating mechanism that ensures that LTM is formed only after repetitive and spaced training.
Isabel
Guillaume
G
Développement, Evolution, Plasticité du Système Nerveux, CNRS, 1 Avenue de la Terrasse, 91190 Gifsur-Yvette, France.
Pascual
Alberto
A
Preat
Thomas
T
D000262:Adenylyl Cyclases / Q000235:genetics / Q000502:physiology; D000818:Animals; D003213:Conditioning, Psychological; D000242:Cyclic AMP / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D017344:Genes, Insect; D007858:Learning; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D024521:Mushroom Bodies / Q000033:anatomy & histology / Q000502:physiology*; D009154:Mutation; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000235:genetics / Q000502:physiology; D009812:Odorants; D019076:Transgenes
D029721:Drosophila Proteins; D009479:Neuropeptides; C093565:amn protein, Drosophila; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; C479926:Rut protein, Drosophila