title: A novel technique with a flexible applicator for MRI-based brachytherapy of cervical cancer.
abstract: OBJECTIVE
  To introduce a novel technique for magnetic resonance (MR)-based 3-dimensional planned high-dose rate intracervical brachytherapy (BT).
  
  
  METHODS
  During 2002, 16 patients received external beam radiotherapy and BT as part of radiochemotherapy for cervical cancer. A special adjustable applicator device was designed and used for BT. The isodose distribution was calculated from MR images with the applicator in place.
  
  
  RESULTS
  The planning target volume coverage was adequate and the radiation burden on the organs at risk was within acceptable limits. Complete regression was achieved in two patients (12.5%), and partial regression in ten (62.5%) patients. The overall response rate for the complex treatment was 93.75%. In three cases the disease was considered to be stable.
  
  
  CONCLUSIONS
  The MR-compatible, flexible applicator allows safe and reproducible cervical radiotherapy with no added discomfort or hazard for the patient.
authors.affiliation: Institute of Diagnostic Imaging and Radiation Oncology, University of Kaposvár, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Hadjiev
authors.forename: G
authors.initials: G
authors.lastname: Antal
authors.forename: Z
authors.initials: Z
authors.lastname: Antalffy
authors.forename: P
authors.initials: P
authors.lastname: Bogner
authors.forename: O
authors.initials: O
authors.lastname: Esik
authors.forename: I
authors.initials: I
authors.lastname: Repa
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008875:Middle Aged; D015642:Radiology, Interventional / Q000295:instrumentation / Q000379:methods; D011879:Radiotherapy Dosage; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*