title: The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia.
abstract: HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.
authors.affiliation: Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Takita Felder
authors.initials: TF
authors.lastname: Sumter
authors.forename: Raka
authors.initials: R
authors.lastname: Bhattacharya
authors.forename: Abeba
authors.initials: A
authors.lastname: Tesfaye
authors.forename: Ephraim J
authors.initials: EJ
authors.lastname: Fuchs
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Wood
authors.forename: David L
authors.initials: DL
authors.lastname: Huso
authors.forename: Linda M S
authors.initials: LM
authors.lastname: Resar
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D005260:Female; D024243:HMGB1 Protein / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D008223:Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009368:Neoplasm Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D019076:Transgenes
chemical_list: D024243:HMGB1 Protein; D012333:RNA, Messenger