title: [Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].
abstract: OBJECTIVE
  To provide basic data for the synthesis of new sinomenine derivatives.
  
  
  METHODS
  The C ring in sinomenine was modified.
  
  
  RESULTS
  Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities.
  
  
  CONCLUSIONS
  Modification of the C ring in sinomenine should be worthy to be studied further.
authors.affiliation: Institute of Materia Medica Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. xianrongye@imm.ac.cn
authors.forename: Xian-rong
authors.initials: XR
authors.lastname: Ye
authors.forename: Ke-xu
authors.initials: KX
authors.lastname: Yan
authors.forename: Ke-mei
authors.initials: KM
authors.lastname: Wu
authors.forename: Xiao-zhang
authors.initials: XZ
authors.lastname: Feng
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Huang
authors.forename: Ping
authors.initials: P
authors.lastname: Qiu
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000473:pathology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009019:Morphinans / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D010147:Pain Measurement; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D032841:Sinomenium / Q000737:chemistry*
chemical_list: C488562:6,7-dihydroxy-7,8- dihydro-sinomenine; C488563:7beta-methoxy-dihydro-sinomenine; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009019:Morphinans; C009271:sinomenine