[Chlamydia pneumoniae as a pathogenetic risk factor in the development of arteriosclerosis and its complications].
The literature data and the results of the authors' experiments allow one to consider Chlamydia pneumoniae as one of the leading risk factor of development of atherosclerosis and ischemic heart disease. Features of atherosclerosis morphogenesis in the presence of Chlamydia are described. Data, showing similarity of cell reactions, characterizing immune inflammation in mLDL deposit in arterial wall and obligate parasites are described. Synergism in the action of mLDL and chlamydial infection may induce a "malignant" course of atherogenesis promoting thrombosis and ischemic heart disease excerbation.
Nagornev
V A
VA
I. P. Pavlov State Research Institute of Experimental Medicine, 197376, St.-Petersburg.
Mal'tseva
S V
SV
Seliverstova
V G
VG
Sokurenko
G Iu
GIu
Voskan'iants
A N
AN
D000818:Animals; D001161:Arteriosclerosis / Q000150:complications* / Q000382:microbiology* / Q000473:pathology; D023521:Chlamydophila Infections / Q000150:complications* / Q000382:microbiology* / Q000473:pathology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification / Q000472:pathogenicity* / Q000648:ultrastructure; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors