Protection of newborn organism against effect of oxidative stress.
OBJECTIVE
The aim of the present study was to investigate influence of oxidative stress on newborn organism, in terms of the dynamics of malondialdehyde (MDA) concentration changes and of the activities of selected antioxidants in asphyxial newborns on the 1st and 5th day of life.


METHODS
In the group of 62 preterm and term asphyxial newborns, characterized by the presence of asphyxial criteria and admitted within 24 hours of life, the plasma concentration of MDA and level of total antioxidant status (TAS) were followed.


RESULTS
Dynamic changes of MDA signalized active process of lipoperoxidation (LP) and values of TAS were decreased in comparison with the capacity of adult patients.
Brucknerová
I
I
1st Department of Paediatrics, Medical School, Comenius University, Bratislava, Slovak Republic. exfadubm@savba.sk
Benedeková
M
M
Pechán
I
I
Franková
E
E
Ujházy
E
E
Dubovický
M
M
D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism*; D001238:Asphyxia Neonatorum / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress
D000975:Antioxidants; D008315:Malondialdehyde