Micronuclei in lymphocytes of uranium miners of the former Wismut SDAG.
We studied micronucleus frequencies in former German uranium miners of the Wismut SDAG (Sowjetisch-Deutsche Aktiengesellschaft). Various other groups were analyzed for comparison (individuals with lung tumors or lung fibrosis, controls). We had shown previously that micronucleus frequencies were not different among the various groups. Differences were observed, however, when centromere-positive and -negative micronuclei were distinguished. In the analyses presented here, we looked for the effects of smoking habits, alcohol consumption, vitamin uptake, chronic diseases, allergies, doing sports, gamma-GT (gamma-glutamyltranspeptidase), lymphocyte numbers, CEA (carcinoembryonic antigen), X-ray diagnostics, computer tomographies, and scintigraphies. With the exception of more than one scintigraphy carried out during the last four months before micronucleus analysis, none of the factors mentioned above significantly affected micronucleus numbers. One result deserves specific attention: individuals with low percentages of binucleated lymphocytes after in vitro cytochalasin B exposure showed higher micronucleus frequencies than those individuals with high percentages of binucleated cells. The same result was obtained for various other populations that we monitored in the past.
Müller
W-U
WU
Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Essen, Germany. wolfgang-ulrich.mueller@uni-essen.de
Kryscio
A
A
Streffer
C
C
D000428:Alcohol Drinking / Q000097:blood / Q000235:genetics; D000512:Alpha Particles / Q000009:adverse effects; D002467:Cell Nucleus / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D002503:Centromere / Q000648:ultrastructure; D043171:Chromosomal Instability / Q000235:genetics; D003571:Cytochalasin B / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects; D005858:Germany; D008019:Life Style; D008175:Lung Neoplasms / Q000097:blood / Q000235:genetics; D008214:Lymphocytes / Q000648:ultrastructure*; D015162:Micronucleus Tests / Q000379:methods; D008906:Mining; D009784:Occupational Diseases / Q000097:blood / Q000209:etiology / Q000235:genetics; D016273:Occupational Exposure; D011658:Pulmonary Fibrosis / Q000097:blood / Q000235:genetics; D011877:Radionuclide Imaging / Q000009:adverse effects / Q000706:statistics & numerical data; D011886:Radon; D012307:Risk Factors; D012907:Smoking / Q000097:blood / Q000235:genetics; D013997:Time Factors; D014501:Uranium
D003571:Cytochalasin B; D014501:Uranium; D011886:Radon