Transcripts of aging.
Recently, it has been demonstrated that similar alterations in gene expression profiles occur in cells from patients with Werner syndrome and from normally aged individuals. Changes involving the genes that are involved in RNA and DNA metabolism were particularly frequent - highlighting the importance of the smooth progression of replication and transcription for maintaining youthful vigor. In this article, we discuss the implications of this work for our understanding of the molecular basis of aging and the increasingly important role of microarrays for unraveling the functional pathways underlying the aging phenotype.
Vijg
Jan
J
Department of Physiology and Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, STCBM Building, 15355 Lambda Drive, Suite 2.200, San Antonio, TX 78245, USA. vijg@uthscsa.edu
Calder
R Brent
RB
D000375:Aging / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle / Q000235:genetics; D004247:DNA / Q000378:metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D012313:RNA / Q000378:metabolism; D014158:Transcription, Genetic; D014898:Werner Syndrome / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
D012313:RNA; D004247:DNA