title: Efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for the treatment of acute postpartum metritis in dairy cows.
abstract: OBJECTIVE
  To evaluate the efficacy of ceftiofur hydrochloride sterile suspension administered parenterally for treatment of acute postpartum metritis (APM) in dairy cows.
  
  
  METHODS
  Multilocation, randomized block, field trial.
  
  
  METHODS
  406 cows in the first 14 days postpartum.
  
  
  METHODS
  Cows with rectal temperatures > or = 39.5 degrees C (103.1 degrees F) without clinical signs of respiratory or gastrointestinal tract disease and with a fetid vaginal discharge were allocated randomly in blocks of 3 to 3 treatment groups: sterile saline (0.9% NaCl) solution administered at a dosage of 2 mL/45.4 kg (2 mL/100 lb), SC or IM, once daily for 5 days (control); or ceftiofur hydrochloride administered at a dosage of 1.1 or 2.2 mg of ceftiofur equivalents (CE)/kg (0.5 or 1 mg/lb, respectively), SC or IM, once daily for 5 days. Cows were evaluated on days 6, 10, and 14, and clinical cure or failure to cure was determined. Clinical cure was defined as no additional antimicrobial treatment administered, rectal temperature < 39.5 degrees C, and absence of a fetid vaginal discharge.
  
  
  RESULTS
  On day 14, clinical cure rates were 77%, 65%, and 62% for the 2.2 mg of CE/kg, 1.1 mg of CE/kg, and control groups, respectively. No significant differences were detected in clinical cure rates between control and treatment groups on day 10 or 6.
  
  
  CONCLUSIONS
  Ceftiofur hydrochloride administered at a dosage of 2.2 mg of CE/kg, SC or IM, once daily for 5 days was efficacious for treatment of APM in dairy cows.
authors.affiliation: Pfizer Animal Health, 0225-190-42, 7000 Portage Rd, Kalamazoo, MI 49001, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Chenault
authors.forename: Joseph F
authors.initials: JF
authors.lastname: McAllister
authors.forename: S Theodore
authors.initials: ST
authors.lastname: Chester
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Dame
authors.forename: Fabian M
authors.initials: FM
authors.lastname: Kausche
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Robb
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004716:Endometritis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D049590:Postpartum Period; D011247:Pregnancy; D011897:Random Allocation; D013535:Suspensions; D016896:Treatment Outcome; D019522:Vaginal Discharge / Q000188:drug therapy / Q000662:veterinary
chemical_list: D002511:Cephalosporins; D013535:Suspensions; C053503:ceftiofur