title: Glucose-based total parenteral nutrition does not stimulate glucose uptake by humans tumours.
abstract: BACKGROUND
  Since glucose represents the preferred fuel for cancer cells, there is some debate about the potential stimulation of tumour metabolism induced by a glucose-based total parenteral nutrition (TPN) in cancer patients.
  
  
  METHODS
  We investigated the uptake of [18]2-fluoro-2-deoxy-D-glucose (FDG) through the positron emission tomography of the healthy liver and of the tumour in 12 patients with liver metastases from colorectal cancer. We determined whether FDG uptake by the tumour in fasting conditions was affected by the subsequent administration of a glucose-based (GTPN) or a lipid-based (LTPN) containing glucose 4 mg/kg/min or lipid 2 mg/kg/min, respectively, as non-protein energy source.
  
  
  RESULTS
  The data showed that FDG uptake by the metastases was 3-3.6 times higher than by the healthy liver in fasting conditions and it was not significantly affected by the subsequent administration of GTPN or LTPN.
  
  
  CONCLUSIONS
  We speculated that, despite glucose being the preferred fuel for cancer cells, its disproportionately high uptake even in fasting conditions makes the glucose consumption unable to be modulated by a further supply of glucose or lipid.
authors.affiliation: Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, Milan 20133, Italy. dottfb@tin.it
authors.forename: Federico
authors.initials: F
authors.lastname: Bozzetti
authors.forename: Cecilia
authors.initials: C
authors.lastname: Gavazzi
authors.forename: Luigi
authors.initials: L
authors.lastname: Mariani
authors.forename: Flavio
authors.initials: F
authors.lastname: Crippa
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000628:therapy; D005215:Fasting / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D019275:Radiopharmaceuticals / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose