title: Expression of cell cycle-related gene products in different forms of primary versus recurrent PVNS.
abstract: Expression patterns of cell cycle regulating gene products and Ki-67 in proliferating synovial cells of primary and recurrent pigmented villonodular synovitis (PVNS) in localized and diffuse lesions were examined by immunohistochemistry. Alterations of cell cycle-related proteins were seen in 98.7% of analyzed lesions. Both RB- and p53 pathways play a role in cell cycle dysregulation in PVNS. The RB pathway was more frequently altered in primary disease, while alterations of the p53 pathway seemed to be more important in recurrent lesions, regardless of the histomorphological type of disease. Ki-67 proliferation rate was elevated in recurrent tumors.
authors.affiliation: Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany. helgard_weckauf@med.uni-heidelberg.de
authors.forename: Helgard
authors.initials: H
authors.lastname: Weckauf
authors.forename: Birgit
authors.initials: B
authors.lastname: Helmchen
authors.forename: Ulf
authors.initials: U
authors.lastname: Hinz
authors.forename: Carola
authors.initials: C
authors.lastname: Meyer-Scholten
authors.forename: Sebastian
authors.initials: S
authors.lastname: Aulmann
authors.forename: Herwart F
authors.initials: HF
authors.lastname: Otto
authors.forename: Irina
authors.initials: I
authors.lastname: Berger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D050684:E2F Transcription Factors; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016160:Retinoblastoma Protein / Q000378:metabolism*; D013586:Synovitis, Pigmented Villonodular / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D019394:Ki-67 Antigen; D016160:Retinoblastoma Protein; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53