Use of recombinant congenic strains in mapping disease-modifying genes.
Previous research studies have established much information about single-gene diseases. However, other genes also influencing the outcome of a disease and genes involved in complex disease remain largely unknown. Here we report on recombinant congenic strains of mice, a powerful tool for genetic dissection of a complex trait.
Müllerová
Jana
J
Department of Cell Ultrastructure and Molecular Biology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 142 20 Prague, Czech Republic.
Hozák
Pavel
P
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D006801:Humans; D051379:Mice; D020297:Mice, Congenic / Q000235:genetics*; D008822:Mice, Transgenic / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*