title: Losartan may prevent the elevation of plasma glucose levels induced by chronic stress.
abstract: The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and renin-angiotensin system.
authors.affiliation: Istanbul University, Istanbul Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 34390 Capa, Istanbul, Turkey. yagiz@istanbul.edu.tr
authors.forename: Yağiz
authors.initials: Y
authors.lastname: Uresin
authors.forename: Bahar
authors.initials: B
authors.lastname: Erbaş
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozek
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D019808:Losartan / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000097:blood* / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D019808:Losartan