title: Asymmetric activation of extracellular signal-regulated kinase 1/2 in rat vestibular nuclei by unilateral labyrinthectomy.
abstract: The expression of phosphorylated extracellular signal-regulated kinase 1/2 (pERK 1/2) was evaluated in the vestibular nuclei (VN) of rats following unilateral labyrinthectomy (UL). Immunohistochemistry revealed a significant asymmetrical increase in pERK 1/2 expression in the VN, 5 min after UL, after which pERK 1/2 immunoreactivity decreased rapidly and was undetectable by 90 min after UL. These results suggest that unilateral deafferentation of the vestibular system triggers intracellular signal pathways that activate ERK 1/2 in the VN.
authors.affiliation: Vestibulocochlear Research Center and Department of Physiology, Wonkwang University School of Medicine, 344-2 Shinyong-dong, Iksan 570-749, South Korea.
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Myoung Ae
authors.initials: MA
authors.lastname: Choi
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Choi
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Kwang Yong
authors.initials: KY
authors.lastname: Kim
authors.forename: Jeong Kyun
authors.initials: JK
authors.lastname: Rhee
authors.forename: Yuan Zhe
authors.initials: YZ
authors.lastname: Jin
authors.forename: Byung Rim
authors.initials: BR
authors.lastname: Park
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015153:Blotting, Western / Q000379:methods; D002452:Cell Count / Q000379:methods; D007758:Ear, Inner / Q000601:surgery; D007839:Functional Laterality / Q000502:physiology; D007150:Immunohistochemistry / Q000379:methods; D007759:Labyrinth Diseases / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D010766:Phosphorylation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014726:Vestibular Nuclei / Q000201:enzymology*
chemical_list: D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases