title: Effect of perindopril on platelet nitric oxide resistance in patients with chronic heart failure secondary to ischemic left ventricular dysfunction.
abstract: In 15 patients with chronic heart failure of ischemic origin who were not previously treated with angiotensin-converting enzyme inhibitors, platelets exhibited hyperaggregability and impaired responsiveness to the antiaggregatory and cyclic guanosine monophosphate-stimulatory effects of nitric oxide donor sodium nitroprusside compared with normal subjects; this was paralleled by increased blood levels of superoxide radicals. Treatment with perindopril for 4 days significantly improved platelet responses to sodium nitroprusside; there was also a trend toward a decrease in superoxide radical levels.
authors.affiliation: Cardiology Unit, The Queen Elizabeth Hospital, Department of Medicine, The University of Adelaide, Woodville 5011, Adelaide, Southern Australia, Australia.
authors.forename: Yuliy Y
authors.initials: YY
authors.lastname: Chirkov
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Holmes
authors.forename: Jason D
authors.initials: JD
authors.lastname: Martelli
authors.forename: John D
authors.initials: JD
authors.lastname: Horowitz
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D020913:Perindopril / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D013481:Superoxides / Q000097:blood; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000150:complications*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D020030:Nitric Oxide Donors; D013481:Superoxides; D009599:Nitroprusside; D009569:Nitric Oxide; D006152:Cyclic GMP; D020913:Perindopril