Evaluation of porfimer sodium in dogs and cats with spontaneous tumors.
The effect of photodynamic therapy is a function of several variables, including selective retention of the drug in tumor tissue with reduced drug concentration in surrounding normal tissue. A study was designed to determine the pharmacokinetic profile and variability of porfimer sodium in dogs and cats with spontaneous tumors and to thereby determine the optimal timing of its photoactivation in these species. The results of this study indicate that there is marked variability among species in the distribution of porfimer sodium between highly proliferating tissues, which requires careful attention in the design of human and veterinary application of photodynamic therapy with porfimer sodium, as determined in rodent models.
Gloi
Aime M
AM
Department of Physics, Oakland University, Rochester, MI 48309, USA.
Beck
Elsa
E
D000818:Animals; D019540:Area Under Curve; D002371:Cat Diseases / Q000188:drug therapy* / Q000378:metabolism; D002415:Cats; D017323:Dihematoporphyrin Ether / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000378:metabolism; D004285:Dogs; D007275:Injections, Intravenous / Q000662:veterinary; D019042:Muscle Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D010778:Photochemotherapy / Q000662:veterinary*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D017323:Dihematoporphyrin Ether