title: Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient mice.
abstract: Matrix metalloproteinase 19 (MMP-19) is a member of the MMP family of endopeptidases that, in contrast to most MMPs, is widely expressed in human tissues under normal quiescent conditions. MMP-19 has been found to be associated with ovulation and angiogenic processes and is deregulated in diverse pathological conditions such as rheumatoid arthritis and cancer. To gain further insights into the in vivo functions of this protease, we have generated mutant mice deficient in Mmp19. These mice are viable and fertile and do not display any obvious abnormalities. However, Mmp19-null mice develop a diet-induced obesity due to adipocyte hypertrophy and exhibit decreased susceptibility to skin tumors induced by chemical carcinogens. Based on these results, we suggest that this enzyme plays an in vivo role in some of the tissue remodeling events associated with adipogenesis, as well as in pathological processes such as tumor progression.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Spain. amp@correo.uniovi.es
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Pendás
authors.forename: Alicia R
authors.initials: AR
authors.lastname: Folgueras
authors.forename: Elena
authors.initials: E
authors.lastname: Llano
authors.forename: John
authors.initials: J
authors.lastname: Caterina
authors.forename: Françoise
authors.initials: F
authors.lastname: Frerard
authors.forename: Francisco
authors.initials: F
authors.lastname: Rodríguez
authors.forename: Aurora
authors.initials: A
authors.lastname: Astudillo
authors.forename: Agnès
authors.initials: A
authors.lastname: Noël
authors.forename: Henning
authors.initials: H
authors.lastname: Birkedal-Hansen
authors.forename: Carlos
authors.initials: C
authors.lastname: López-Otín
mesh_terms: D017667:Adipocytes / Q000201:enzymology / Q000473:pathology; D000818:Animals; D001483:Base Sequence; D002273:Carcinogens / Q000633:toxicity; D048429:Cell Size; D018076:DNA, Complementary / Q000235:genetics; D004032:Diet; D005260:Female; D018390:Gene Targeting; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D053505:Matrix Metalloproteinases, Secreted; D008666:Metalloendopeptidases / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D008748:Methylcholanthrene / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D018919:Neovascularization, Physiologic; D009765:Obesity / Q000201:enzymology / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D010641:Phenotype; D012878:Skin Neoplasms / Q000201:enzymology / Q000235:genetics / Q000517:prevention & control*
chemical_list: D002273:Carcinogens; D018076:DNA, Complementary; D008748:Methylcholanthrene; D053505:Matrix Metalloproteinases, Secreted; D008666:Metalloendopeptidases; C108362:matrix metalloproteinase 19