title: Lymphangitis carcinomatosis of unknown origin presenting as severe pulmonary hypertension.
abstract: An apparently healthy 46-year-old woman was admitted because of progressive shortness of breath that had begun 2 months before her admission. Physical examination revealed a patient with respiratory distress, tachycardia, and mild jugular venous distention; otherwise, results were unremarkable. Our investigation revealed hypoxia and severe pulmonary hypertension with signs of right heart dysfunction, but no primary cause was found. The patient died 5 days after admission. Autopsy revealed pulmonary lymphangitis carcinomatosis caused by papillary carcinoma. No primary tumor was found.
authors.affiliation: Department of Internal Medicine B, Rambam Medical Center, Haifa, Israel.
authors.forename: Itay
authors.initials: I
authors.lastname: Maza
authors.forename: Eyal
authors.initials: E
authors.lastname: Braun
authors.forename: Ana
authors.initials: A
authors.lastname: Plotkin
authors.forename: Ludmila
authors.initials: L
authors.lastname: Guralnik
authors.forename: Zaher S
authors.initials: ZS
authors.lastname: Azzam
mesh_terms: D002291:Carcinoma, Papillary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008205:Lymphangitis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged