title: Pharmacokinetics and lung tissue concentrations of tulathromycin, a new triamilide antibiotic, in cattle.
abstract: The pharmacokinetics of the new triamilide antibiotic tulathromycin was investigated in two cattle studies. Following a single subcutaneous injection, the drug was rapidly absorbed and bioavailability was excellent. High and persistent levels of the drug in lung tissue were observed as well. These attributes are advantageous for an antimicrobial drug indicated for the treatment of bacterial and mycoplasmal respiratory diseases in cattle.
authors.affiliation: Pfizer Global Research and Development, Groton Laboratories, Veterinary Medicine Safety and Metabolism Group, Eastern Point Road, Groton, CT 06340, USA.
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Nowakowski
authors.forename: Philip B
authors.initials: PB
authors.lastname: Inskeep
authors.forename: Jim E
authors.initials: JE
authors.lastname: Risk
authors.forename: Terry L
authors.initials: TL
authors.lastname: Skogerboe
authors.forename: Hafid A
authors.initials: HA
authors.lastname: Benchaoui
authors.forename: Todd R
authors.initials: TR
authors.lastname: Meinert
authors.forename: John
authors.initials: J
authors.lastname: Sherington
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Sunderland
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002417:Cattle / Q000378:metabolism*; D004187:Disaccharides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008168:Lung / Q000378:metabolism*; D008297:Male; D018942:Macrolides
chemical_list: D000890:Anti-Infective Agents; D004187:Disaccharides; D006571:Heterocyclic Compounds; C485204:tulathromycin; D018942:Macrolides