title: Granulocytic sarcoma presenting with malignant anasarca in a patient with secondary acute myeloid leukemia.
abstract: Granulocytic sarcomas (GS) are rare extramedullary tumor masses composed of immature cells derived from the hematopoietic myeloid series. GS occur in 3% to 7% of cases of acute myeloid leukemia (AML) and can present before, during, or even after the diagnosis of AML. GS can involve different organs, individually or simultaneously, including the skin, lymph nodes, bone, breast, central nervous system, and lung among others. GS involving peritoneal and pleural fluids is a rare presentation. We present an unusual case of a patient with myelodysplastic syndrome whose disease progressed into a secondary AML and developed GS in the ascitic and pleural effusions as the predominant manifestation of disease progression.
authors.affiliation: Section of Hematology-Oncology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd WP 2080, Oklahoma City, OK 73104, USA.
authors.forename: Mohammad Y
authors.initials: MY
authors.lastname: Khan
authors.forename: Khader K
authors.initials: KK
authors.lastname: Hussein
authors.forename: Max G
authors.initials: MG
authors.lastname: Walter
authors.forename: Muhammad K
authors.initials: MK
authors.lastname: Hasan
authors.forename: William
authors.initials: W
authors.lastname: Kern
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Kharfan-Dabaja
mesh_terms: D000368:Aged; D001201:Ascites / Q000209:etiology / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000473:pathology*; D023981:Sarcoma, Myeloid / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology