title: Image contrast agents activated by prostate specific antigen (PSA).
abstract: A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and alpha-chymotrypsin, releasing free fluorophore via cleavage of a three-component system.
authors.affiliation: Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA. gr.jones@neu.edu
authors.forename: Graham B
authors.initials: GB
authors.lastname: Jones
authors.forename: Longfei
authors.initials: L
authors.lastname: Xie
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Shafey
authors.forename: Curtis F
authors.initials: CF
authors.lastname: Crasto
authors.forename: Glenn J
authors.initials: GJ
authors.lastname: Bubley
authors.forename: Anthony V
authors.initials: AV
authors.lastname: D'Amico
mesh_terms: D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism*; D017430:Prostate-Specific Antigen / Q000378:metabolism*
chemical_list: D003287:Contrast Media; D017430:Prostate-Specific Antigen