Activity-dependent synaptic competition at mammalian neuromuscular junctions.
Synapse elimination is a widespread developmental process in the peripheral and central nervous system that brings about refinement of neural connections through epigenetic mechanisms. Here we describe recent advances concerning the role of the pattern of motoneuronal firing, synchronous or asynchronous, in neuromuscular synapse elimination.
Buffelli
Mario
M
Dipartimento di Scienze Neurologiche e della Visione, Sezione di Fisiologia, Universita' di Verona, 37134 Verona, Italy.
Busetto
Giuseppe
G
Bidoia
Carlo
C
Favero
Morgana
M
Cangiano
Alberto
A
D000818:Animals; D008322:Mammals; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation*; D009469:Neuromuscular Junction / Q000502:physiology*; D013569:Synapses / Q000502:physiology*