Heterozygosities and allelic frequencies of 811 dinucleotide-repeat marker loci in the Taiwanese population.
To evaluate basic informativeness of commercially available microsatellite markers in theTaiwanese population, 190 unrelated Taiwanese children were genotyped using ABI PRISM Linkage Mapping Set-HD5. The average heterozygosity in Taiwanese was slightly lower than that in Caucasians among these 811 microsatellite markers. There were 50 marker loci with heterozygosities lower than 50%. Moreover, allelic distributions at many of the loci were significantly different in two ethnic groups. The results reported here represent a valuable database for disease genes mapping in the Taiwanese population. This database can be easily accessed at the Web site of Vita Genomics, Inc. (http://www.vitagenomics.com/str.html).
Lu
Cheng-Hsin
CH
STR Genotyping Laboratory, Research and Development Division, Vita Genomics, Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd, Wugu Shiang, Taipei County, 248, Taiwan.
Lin
Cherry Guan-Ju
CG
STR Genotyping Laboratory, Research and Development Division, Vita Genomics, Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd, Wugu Shiang, Taipei County, 248, Taiwan.
Huang
Lichih
L
STR Genotyping Laboratory, Research and Development Division, Vita Genomics, Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd, Wugu Shiang, Taipei County, 248, Taiwan.
Wang
Ling-Mei
LM
STR Genotyping Laboratory, Research and Development Division, Vita Genomics, Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd, Wugu Shiang, Taipei County, 248, Taiwan.
Wu
Lawrence Shih-Hsin
LS
STR Genotyping Laboratory, Research and Development Division, Vita Genomics, Inc., 7Fl., No. 6, Sec. 1, Jungshing Rd, Wugu Shiang, Taipei County, 248, Taiwan. lawrence.wu@vitagenomics.com.
D000483:Alleles; D044466:Asian People; D019992:Databases as Topic; D018900:Dinucleotide Repeats; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D013624:Taiwan; D044465:White People
D005819:Genetic Markers