Familial clustering of classic Kaposi sarcoma.
It is widely accepted that there is a causal association between Kaposi sarcoma-associated herpesvirus (KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6-promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case.
Guttman-Yassky
Emma
E
Department of Dermatology, Rambam Medical Center, and Department of Cell Biology and Anatomy, Bruce Rappaport Faculty of Medicine, Haifa, Israel.
Cohen
Adina
A
Kra-Oz
Zippi
Z
Friedman-Birnbaum
Rachel
R
Sprecher
Elli
E
Zaltzman
Neli
N
Friedman
Eitan
E
Silbermann
Michael
M
Rubin
Dina
D
Linn
Shai
S
Whitby
Dennis
D
Gideoni
Osnat
O
Pollack
Shimon
S
Bergman
Reuven
R
Sarid
Ronit
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000097:blood; D005260:Female; D020022:Genetic Predisposition to Disease; D019288:Herpesvirus 8, Human; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000276:immunology; D011401:Promoter Regions, Genetic / Q000276:immunology; D012514:Sarcoma, Kaposi / Q000235:genetics* / Q000276:immunology / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D015850:Interleukin-6