title: Exophiala jeanselmei infection in a heart transplant recipient successfully treated with oral terbinafine.
abstract: An immunosuppressed heart transplant recipient developed Exophiala jeanselmei infection on the second toe. After unsuccessful treatment with different antifungal drugs, the infection responded to a high-dose regimen of oral terbinafine (an antifungal agent not yet approved in the United States for use against the dematiaceous fungi) and warm packs. This is, to our knowledge, the only known case of successful terbinafine treatment of E. jeanselmei infection.
authors.affiliation: Gundersen Lutheran Medical Center, La Crosse, WI, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Agger
authors.forename: David
authors.initials: D
authors.lastname: Andes
authors.forename: Joshua W
authors.initials: JW
authors.lastname: Burgess
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005093:Exophiala / Q000187:drug effects / Q000302:isolation & purification*; D005260:Female; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D009281:Naphthalenes / Q000008:administration & dosage* / Q000627:therapeutic use*; D000077291:Terbinafine; D014034:Toes / Q000382:microbiology / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine