Cytotoxic alkaloids from the marine sponge Thorectandra sp.
Three beta-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A (2), and fascaplysin (3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 (breast) with an IC50 of 5.9 microg/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 (ovarian) human tumor cell lines with IC50s of 1.5 and 2.2 microg/mL, respectively.
Charan
Romila D
RD
Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA.
McKee
Tawnya C
TC
Boyd
Michael R
MR
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006576:Heterocyclic Compounds, 4 or More Rings / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology*; D010051:Ovarian Neoplasms / Q000473:pathology; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured; D000644:Quaternary Ammonium Compounds; D002243:Carbolines; D007212:Indolizines
D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; C486669:1-deoxysecofascaplysin A; C069346:fascaplysine; D000644:Quaternary Ammonium Compounds; D002243:Carbolines; D007212:Indolizines