A novel spongiform degeneration of the grey matter in the brain of a kitten.
A young female domestic short-hair cat presented with neurological signs consistent with a multifocal encephalic lesion (depressed mental status, head tilt to the right, cervical ventroflexion, head tremors, tetraparesis, conscious propioceptive deficits in all four limbs and visual deficits). No gross lesions were seen at necropsy. On light microscopical examination lesions were found only in the brain and cervical spinal cord. A generalized vacuolation of the grey matter of the brain was observed. Special staining techniques, immunohistochemistry, lectin affinity histochemistry and ultrastructural studies were performed to characterize the lesion; preservation of the white matter and a reactive astrogliosis were demonstrated. Feline retroviruses and PrPsc were not detected. Ultrastructurally, a dilatation of intracytoplasmic membrane-bounded organelles with membrane disruption and dendritic and somatic swelling was found in astrocytes and neurons. The age of the animal and histological changes suggested a novel, possibly congenital, spongiform degeneration of the brain and cervical spinal cord.
Vidal
E
E
Departament de Medicina i Cirurgia Animals, Institut de Neurociències and Laboratori, Centre de Recerca en Sanitat Animal, Facultad de Veterinaria, Bellaterra, Barcelona, Spain.
Montoliu
P
P
Añor
S
S
Sisó
S
S
Ferrer
I
I
Pumarola
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology / Q000662:veterinary*; D002415:Cats; D005260:Female; D005911:Gliosis / Q000473:pathology; D007150:Immunohistochemistry; D009474:Neurons / Q000473:pathology / Q000648:ultrastructure; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology