title: [Safety and efficacy of autologous blood donation before elective off-pump coronary artery bypass grafting].
abstract: BACKGROUND
  Preoperative autologous blood donation reduces exposure to homologous blood transfusions in cardiac surgery. The purpose of this study was to ascertain, how much volume of predonated autologous blood needed to avoid of homologous blood transfusion in scheduled off-pump coronary artery bypass grafting (OPCAB).
  
  
  METHODS
  Fifty patients underwent scheduled OPCAB. These patients donated 400 ml (group A, n = 30) or 800 ml (group B, n = 20) of autologous blood before operation. These patients donated at a rate of 400 ml per week. All patients were given an equal volume of saline solution at the time of autologous donation.
  
  
  RESULTS
  There were no significant differences mean age, mean body weight, mean preoperative hematocrit values, mean graft number or mean volume of intraoperative blood loss between groups A and B. There was significant difference the mean postoperative day-7 hematocrit value (33.4 +/- 1.5% vs 38.7 +/- 1.5%, p < 0.05). The rates of avoiding homologous blood transfusion were 63.3% in group A and 100% in group B (p < 0.05).
  
  
  CONCLUSIONS
  Autologous blood transfusion was effective for reducing the homologous blood requirement. We believe that 800 ml predonation is sufficient to avoid homologous blood transfusion in scheduled OPCAB, further patients with cardiovascular disease including severe coronary artery should be donated with the administration of saline.
authors.affiliation: Department of Cardiovascular Surgery, Fukuyama Cardiovascular Hospital, Fukuyama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoda
authors.forename: M
authors.initials: M
authors.lastname: Nonoyama
authors.forename: T
authors.initials: T
authors.lastname: Shimakura
mesh_terms: D000368:Aged; D001804:Blood Transfusion, Autologous; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods*; D017558:Elective Surgical Procedures; D004921:Erythropoietin / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged; D011300:Preoperative Care; D012449:Safety
chemical_list: D004921:Erythropoietin