title: Breast tomography with synchrotron radiation: preliminary results.
abstract: A system for in vivo breast imaging with monochromatic x-rays has been designed and built at the synchrotron radiation facility Elettra in Trieste (Italy) and will be operational in 2004. The system design involves the possibility of performing both planar mammography and breast tomography. In the present work, the first results obtained with a test set-up for breast tomography are shown and discussed. Tomographic images of in vitro breasts were acquired using monochromatic x-ray beams in the energy range 20-28 keV and a linear array silicon pixel detector. Tomograms were reconstructed using standard filtered backprojection algorithms; the effect of different filters was evaluated. The attenuation coefficients of fibroglandular and adipose tissue were measured, and a quantitative comparison of images acquired at different energies was performed by calculating the differential signal-to-noise ratio of fibroglandular details in adipose tissue. All images required a dose comparable to the dose delivered in clinical, conventional mammography and showed a high resolution of the breast structures without the overlapping effects that limit the visibility of the structures in 2D mammography. A quantitative evaluation of the images proves that the image quality at a given dose increases in the considered energy range and for the considered breast sizes.
authors.affiliation: Department of Physics, University of Trieste, INFN, Trieste Section, via Valerio 2, I 34126 Trieste, Italy. pani@ts.infn.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Pani
authors.forename: Renata
authors.initials: R
authors.lastname: Longo
authors.forename: Diego
authors.initials: D
authors.lastname: Dreossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Montanari
authors.forename: Alessandro
authors.initials: A
authors.lastname: Olivo
authors.forename: Fulvia
authors.initials: F
authors.lastname: Arfelli
authors.forename: Anna
authors.initials: A
authors.lastname: Bergamaschi
authors.forename: Paolo
authors.initials: P
authors.lastname: Poropat
authors.forename: Luigi
authors.initials: L
authors.lastname: Rigon
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Zanconati
authors.forename: Ludovico
authors.initials: L
authors.lastname: Dalla Palma
authors.forename: Edoardo
authors.initials: E
authors.lastname: Castelli
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D003238:Connective Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D007558:Italy; D008327:Mammography / Q000295:instrumentation / Q000379:methods; D011827:Radiation; D011829:Radiation Dosage; D012825:Silicon; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D012825:Silicon