Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.
PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4-induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.
Göke
Rüdiger
R
Clinical Research Unit for Gastrointestinal Endocrinology, University of Marburg, Marburg, Germany. goeke@mailer.uni-marburg.de
Gregel
Cornelia
C
Göke
Alexandra
A
Arnold
Rudolf
R
Schmidt
Harald
H
Lankat-Buttgereit
Brigitte
B
D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D002276:Carcinoid Tumor; D045744:Cell Line, Tumor; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D010190:Pancreatic Neoplasms; D016601:RNA-Binding Proteins / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; C114487:PDCD4 protein, human; D016601:RNA-Binding Proteins