title: [Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus].
abstract: It was demonstrated by subtractive hybridization that the infection of a human embryonic kidney cell line with tick-borne encephalitis virus causes an approximately tenfold transcription activation of the RIG-1 gene, which encodes a protein of the DExH/D-box-containing RNA helicase family. A possible involvement of the protein in antiviral cell systems is discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
authors.affiliation: Shemyakin-Ovchinnikov, Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997 Russia. gal@humgen.siobc.ras.ru
authors.forename: G S
authors.initials: GS
authors.lastname: Monastyrskaia
authors.forename: M B
authors.initials: MB
authors.lastname: Kostina
authors.forename: O B
authors.initials: OB
authors.lastname: Filiukova
authors.forename: E V
authors.initials: EV
authors.lastname: Protopopova
authors.forename: S N
authors.initials: SN
authors.lastname: Konovalova
authors.forename: A V
authors.initials: AV
authors.lastname: Kachko
authors.forename: L G
authors.initials: LG
authors.lastname: Nikolaev
authors.forename: V B
authors.initials: VB
authors.lastname: Loktev
authors.forename: E D
authors.initials: ED
authors.lastname: Sverdlov
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D017931:DNA Primers; D004669:Encephalitis Viruses, Tick-Borne / Q000502:physiology*; D006801:Humans; D009693:Nucleic Acid Hybridization; D020365:RNA Helicases / Q000235:genetics*; D011971:Receptors, Immunologic; D013382:Subtraction Technique
chemical_list: D017931:DNA Primers; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases