A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase.
9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy as inhibitors of NCED was examined. One of the synthesized compounds (20) was found to be an inhibitor of this enzyme, and inhibited ABA accumulation and stomatal closing, suggesting that 20 should be ABA biosynthesis inhibitor.
Han
Sun-Young
SY
RIKEN Tsukuba Institute, Koyadai 3-1-1, Ibaraki, Tsukuba 305-0074, Japan.
Kitahata
Nobutaka
N
Saito
Tamio
T
Kobayashi
Masatomo
M
Shinozaki
Kazuo
K
Yoshida
Shigeo
S
Asami
Tadao
T
D000040:Abscisic Acid / Q000096:biosynthesis*; D049308:Dioxygenases; D016503:Drug Delivery Systems / Q000379:methods*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D010105:Oxygenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018515:Plant Leaves / Q000201:enzymology; D010940:Plant Proteins; D018724:Spinacia oleracea / Q000187:drug effects / Q000201:enzymology
D004791:Enzyme Inhibitors; D010940:Plant Proteins; D000040:Abscisic Acid; D010105:Oxygenases; D049308:Dioxygenases; C109043:9-cis-epoxy-carotenoid dioxygenase