title: Refinement of a locus for Marie Unna hereditary hypotrichosis to a 1.1-cM interval at 8p21.3.
abstract: BACKGROUND
  Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal congenital alopecia with progressive hair loss starting in early childhood and accelerating at puberty. A locus for MUHH has been mapped on chromosome 8p21 but no genes for MUHH have been identified to date.
  
  
  OBJECTIVE
  To refine the MUHH locus to a narrow chromosome region to facilitate cloning of the gene.
  
  
  METHODS
  We performed genotyping and linkage analysis in a multigeneration Chinese family with MUHH, using 18 high-density microsatellite markers spanning the previously mapped interval at 8p21.
  
  
  RESULTS
  Significant evidence for linkage was observed in this region, with a maximum two-point LOD score of 3.01 (theta = 0). Haplotype analysis localized the MUHH locus within the region defined by D8S282 and D8S1839. This region overlaps by 1.1-cM with the previously reported MUHH region and represents a physical distance of about 380 kb.
  
  
  CONCLUSIONS
  This study provides a refined map location (1.1 cM) for isolation of the gene causing MUHH. These data also indicate the existence of a common MUHH locus at 8p21.3 between affected caucasian and Chinese families.
authors.affiliation: Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, and Key Laboratory of Genome Research at Anhui, 69 Meishan Road, Hefei, 230032 Anhui, China.
authors.forename: P P
authors.initials: PP
authors.lastname: He
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Li
authors.forename: Y H
authors.initials: YH
authors.lastname: Liang
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: K L
authors.initials: KL
authors.lastname: Yan
authors.forename: Y
authors.initials: Y
authors.lastname: Cui
authors.forename: Y Y
authors.initials: YY
authors.lastname: Shen
authors.forename: H Y
authors.initials: HY
authors.lastname: Wang
authors.forename: L D
authors.initials: LD
authors.lastname: Sun
authors.forename: W H
authors.initials: WH
authors.lastname: Du
authors.forename: Y J
authors.initials: YJ
authors.lastname: Shen
authors.forename: S J
authors.initials: SJ
authors.lastname: Xu
authors.forename: W
authors.initials: W
authors.lastname: Huang
mesh_terms: D000368:Aged; D000505:Alopecia / Q000235:genetics / Q000473:pathology; D002648:Child; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004252:DNA Mutational Analysis; D018450:Disease Progression; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007039:Hypotrichosis / Q000151:congenital / Q000235:genetics* / Q000473:pathology; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree