title: Worsening myelopathy masked by peripheral nerve disorders.
abstract: OBJECTIVE
  Peripheral nerve disorders--whether due to peripheral nerve entrapment or to polyneuropathy--can alter the signs of myelopathy, masking both the sensory loss and distal hyperreflexia. Diagnosis of worsening myelopathy may be missed when there is a coexisting peripheral nerve disorder.
  
  
  METHODS
  This study is a case description and analysis of 3 consecutive cases identified over 2 years.
  
  
  RESULTS
  Three cases were identified in which the diagnosis of worsening myelopathy was missed and treatment was delayed because neurologic decline was attributed to a coexisting peripheral nerve disorder. This report describes 2 cases of posttraumatic syringomyelia masked by superimposed peripheral nerve entrapments and 1 case of cervical myelopathy due to cervical spinal stenosis from ossification of the posterior longitudinal ligament masked by diabetic polyneuropathy.
  
  
  CONCLUSIONS
  It is important to continually question whether the working diagnosis of peripheral nerve disorder explains the clinical findings, given neurologic decline; or whether a superimposed worsening myelopathy may coexist. Early diagnosis of worsening myelopathy is important, because prompt treatment of syringomyelia and myelopathy due to cervical spinal stenosis may yield better outcomes. Early diagnosis is aided by (a) considering alternative and multiple diagnoses, (b) assessing spinothalamic as well as posterior column sensation and assessing these sensory modalities for proximal as well as distal limbs, (c) assessing tendon hyperreflexia of proximal as well as distal limb muscles, and (d) utilizing electrodiagnostic tests that can identify myelopathy.
authors.affiliation: Spinal Cord Injury Service, DVA Puget Sound Health Care System, Seattle, Washington 98108, USA.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Rittenberg
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Burns
authors.forename: James W
authors.initials: JW
authors.lastname: Little
mesh_terms: D000328:Adult; D002574:Cervical Vertebrae; D003929:Diabetic Neuropathies / Q000150:complications; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D006801:Humans; D008297:Male; D008875:Middle Aged; D009408:Nerve Compression Syndromes / Q000150:complications; D017887:Ossification of Posterior Longitudinal Ligament / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D013118:Spinal Cord Diseases / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology; D013130:Spinal Stenosis / Q000150:complications / Q000175:diagnosis / Q000209:etiology; D013595:Syringomyelia / Q000175:diagnosis / Q000209:etiology