[Characterization of custom-made biomaterials containing antibiotics].
The aim of this study was to evaluate the quality of custom-made antibiotic carriers which are produced for hospitals in a central service laboratory. These sterile products, made according to antibiogram, showed quality parameters which are comparable with commercially available products in terms of antibiotic release and other relevant properties.
Pfefferle
H-J
HJ
Biomet Merck BioMaterials GmbH, Darmstadt. hans-joachim.pfefferle@merck.de
Nies
B
B
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D001682:Biological Availability; D001843:Bone Cements; D004337:Drug Carriers; D004339:Drug Compounding; D005839:Gentamicins / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D008768:Methylmethacrylates / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D004337:Drug Carriers; D005839:Gentamicins; D008768:Methylmethacrylates; C030159:gentamicin-polymethylmethacrylate bead