New piperidine scaffolds via nucleophilic reactivity of (-)-phenyloxazolopiperidine.
The present work illustrates the power of compound 2 as a chiral, nonracemic, and stable 2-piperideine (enamine) equivalent in the rapid and efficient construction of 3-substituted piperidines (carbon-carbon and carbon-sulfur bonds) such as 3-spiropiperidines. This methodology offers a new route to such systems that could compete with previously reported strategies.
Poupon
Erwan
E
Laboratoire de Pharmacognosie Associé au CNRS, UMR 8076 (BioCIS), Centre d'Etudes Pharmaceutiques, Université Paris-Sud 11, 5, Rue Jean-Baptiste Clément, 92296 Châtenay-Malabry CEDEX, France.
François
David
D
Kunesch
Nicole
N
Husson
Henri-Philippe
HP