title: Selective dopamine filter of glutamate striatal afferents.
abstract: Corticostriatal glutamate afferents and mesostriatal dopamine afferents commonly converge onto the same postsynaptic spines of medium projection neurons. The consequent synaptic triad provides an ideal configuration for dopamine modulation of glutamatergic transmission. In this issue of Neuron, Bamford et al. report that dopamine inhibits glutamate release in a selective manner by activating presynaptic D2 receptors.
authors.affiliation: Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030 USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Dani
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Zhou
mesh_terms: D000344:Afferent Pathways / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D017448:Receptors, Dopamine D2; D018698:Glutamic Acid; D004298:Dopamine