Molecular signaling of somatostatin receptors.
Somatostatin is a neuropeptide family that is produced by neuroendocrine, inflammatory, and immune cells in response to different stimuli. Somatostatin acts as an endogenous inhibitory regulator of various cellular functions including secretions, motility, and proliferation. Its action is mediated by a family of G-protein-coupled receptors (called sst1-sst5) that are widely distributed in the brain and periphery. The five receptors bind the natural peptides with high affinity, but only sst2, sst5, and sst3 bind the short synthetic analogs used to treat acromegaly and neuroendocrine tumors. This review covers the current knowledge in somatostatin receptor biology and signaling.
Lahlou
Hicham
H
INSERM U 531, IFR 31, CHU Rangueil, 31403 Toulouse Cedex 4, France.
Guillermet
Julie
J
Hortala
Marylis
M
Vernejoul
Fabienne
F
Pyronnet
Stéphane
S
Bousquet
Corinne
C
Susini
Christiane
C
D006801:Humans; D018358:Neuroendocrine Tumors / Q000503:physiopathology*; D017481:Receptors, Somatostatin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D017481:Receptors, Somatostatin