title: In vitro activity of OPT-80 against Clostridium difficile.
abstract: Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.
authors.affiliation: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstrasse 24, 04103 Leipzig, Germany. ackermg@medizin.uni-leipzig.de
authors.forename: Grit
authors.initials: G
authors.lastname: Ackermann
authors.forename: Birgit
authors.initials: B
authors.lastname: Löffler
authors.forename: Daniela
authors.initials: D
authors.lastname: Adler
authors.forename: Arne C
authors.initials: AC
authors.lastname: Rodloff
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D016360:Clostridioides difficile / Q000187:drug effects*; D003015:Clostridium Infections / Q000382:microbiology; D003470:Culture Media; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D003470:Culture Media; D006027:Glycosides; C487655:OPT 80