High intensity exercise enhances platelet reactivity to shear stress and coagulation during and after exercise.
Platelets play a crucial role in the pathogenesis of acute cardiac events, such as angina, myocardial infarction and sudden death. It is believed that regular low-intensity exercise can reduce, while high-intensity exercise may provoke acute cardiac events. The aim of the present study was to investigate the effect of acute exercise both at low and high intensities on the ventilatory threshold (VT), platelet reactivity and coagulation before and after exercise. Platelet reactivity and coagulation were measured under flow condition, using native blood, by hemostatometry. Seven healthy young men (age: 20-29 years) performed bicycle ergometer exercise for 30 min at intensities of 90% (Ex-VT90% or approximately 55% VO(2max)) and 130% (Ex-VT130% or 80% VO(2max)) of individual VT. Blood cell counts, hematocrit, blood lactic acid and plasma catecholamine levels were slightly but significantly increased after Ex-VT90% and markedly after Ex-VT130% after 30 min exercise. Subsequent to the exercise, the elevated blood cell counts decreased to the resting levels both at Ex-VT90% and at Ex-VT130%. Platelet reactivity to shear stress and dynamic coagulation were significantly enhanced immediately and 30 min after Ex-130%VT. In contrast, no significant changes occurred in those of Ex-90%VT. The present study suggests that high-intensity exercise-induced platelet hyperreactivity and hypercoagulable state may pose an increased risk for acute, sometimes fatal cardiac event. On the other hand, our findings support the view that low-intensity exercise does not present a risk of thrombosis.
Ikarugi
Hideo
H
Laboratory of Health and Sport Sciences, University of Hyogo, Kobe, Japan. ikarugi@econ.u-hyogo.ac.jp
Shibata
Masashi
M
Shibata
Shiori
S
Ishii
Hiromitsu
H
Taka
Tomomi
T
Yamamoto
Junichiro
J
D000328:Adult; D001777:Blood Coagulation; D001835:Body Weight; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate; D006403:Hematologic Tests; D018056:Hemorheology; D006801:Humans; D008297:Male; D015539:Platelet Activation / Q000502:physiology*; D012123:Pulmonary Ventilation; D013314:Stress, Mechanical