The effects of L-carnitine on presbyacusis in the rat model.
Reactive oxygen metabolites are products of oxidative metabolism that are continuously generated in vivo, and are known to produce serious cellular, tissue and genomic damage. l-carnitine is an endogenous amine that has been shown to have an effect on the synthesis of reactive oxygen metabolites. Twenty Wistar rats, 24 months of age, were randomly assigned to two groups as control and l-carnitine treatment groups. One millilitre of distilled water was administered to control rats and 50 mg/kg l-carnitine to rats of l-carnitine treatment groups by intragastric gavage once a day for 30 days. At the end of 30 days, all groups underwent auditory brainstem response testing after administration of intraperitoneal urethane anaesthesia. l-carnitine treatment reduced III, V latencies and I-III, III-V and I-V interpeak latencies (IPL) significantly compared with the control group. l-carnitine treatment improved age-related deterioration in auditory pathways and hence may be a new alternative for the treatment of presbyacusis.
Derin
A
A
Ear, Nose, Throat, Head and Neck Surgery Department, Faculty of Medicine, Akdeniz University, Antalya, Turkey. alperderin@ixir.com
Agirdir
B
B
Derin
N
N
Dinç
O
O
Güney
K
K
Ozcaglar
H
H
Kilinçarslan
S
S
D000375:Aging / Q000502:physiology*; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D002331:Carnitine / Q000494:pharmacology / Q000627:therapeutic use*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects* / Q000502:physiology; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D023421:Models, Animal; D011304:Presbycusis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism*
D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D002331:Carnitine