title: [Subclinical hypothyroidism; the start of a clinical trial into the usefulness of treatment with radioactive iodine].
abstract: Subclinical hyperthyroidism is defined as the presence of serum free thyroxine (T4) and triiodothyronine (T3) levels within the reference range and a reduced serum thyrotrophin (TSH) level. Evidence is accumulating that it has important clinical effects. Randomised clinical trials are needed to answer the question whether or not treatment of subclinical hyperthyroidism prevents cardiac problems, especially atrial fibrillation, and preserves bone mineral density. A randomised, Dutch multicentre trial has recently been started. Its goal is to study whether radioiodine treatment prevents the development of atrial fibrillation and prevents decreases in bone mineral density.
authors.affiliation: Afd. Endocriene Ziekten, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen. e.hoogendoorn@endo.umcn.nl
authors.forename: E H
authors.initials: EH
authors.lastname: Hoogendoorn
authors.forename: W M
authors.initials: WM
authors.lastname: Wiersinga
authors.forename: M F
authors.initials: MF
authors.lastname: Prummel
authors.forename: M
authors.initials: M
authors.lastname: den Heijer
authors.forename: F H
authors.initials: FH
authors.lastname: Corstens
authors.forename: A R
authors.initials: AR
authors.lastname: Hermus
mesh_terms: D001281:Atrial Fibrillation / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013960:Thyroid Function Tests; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D016896:Treatment Outcome; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine