title: Surgical correction of craniosynostosis in malignant osteopetrosis.
abstract: In osteopetrosis, bone healing is complicated by progressive sclerosis. A 2-year-old blind boy with malignant osteopetrosis developed increased intracranial pressure secondary to craniosynostosis. Osteopetrosis had already been treated with bone marrow transplantation (BMT), and bone remodeling seemed to be restored. A craniotomy was performed. The postoperative course and bone healing were uneventful. After successful BMT, craniofacial procedures seem to be possible without a high risk for osteomyelitis.
authors.affiliation: Departments of Oral and Maxillofacial Plastic Surgery, University Hospital Tübingen, Germany. Michael.Krimmel@med.uni-tuebingen.de
authors.forename: Michael
authors.initials: M
authors.lastname: Krimmel
authors.forename: Gerhard
authors.initials: G
authors.lastname: Niemann
authors.forename: Bernd
authors.initials: B
authors.lastname: Will
authors.forename: Siegmar
authors.initials: S
authors.lastname: Reinert
mesh_terms: D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D003398:Craniosynostoses / Q000150:complications* / Q000601:surgery*; D003399:Craniotomy / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology; D008297:Male; D010022:Osteopetrosis / Q000150:complications* / Q000601:surgery