Human papillomavirus infection and cervical ectopy.
OBJECTIVE
To investigate the prevalence of human papillomavirus (HPV), and HPV type 16 (HPV16) infection in cervical ectopy, and the presence of anti-HPV16 secretory IgA (sIgA) antibodies.


METHODS
DNA from patients with cervical ectopy (n=218), HPV-associated lesions (n=111), and controls without evidence of cervical ectopy or HPV infection (n=93) were analyzed by PCR for the presence of HPV and HPV16. The presence of mucosal sIgA antibodies against HPV16 capsid antigens (VLP) was assayed in cervical mucus by ELISA.


RESULTS
Prevalence of HPV DNA was higher in cervical ectopy than in controls (P=0.04; OR=2.06; 95% CI 0.99-4.33). HPV16 was 6.3 times more prevalent in cervical ectopy than in controls. Anti-HPV16 sIgA were detected more frequently in cervical ectopy patients than in controls (P=0.0004).


CONCLUSIONS
Cervical ectopy correlates with HPV infection. HPV16 is highly prevalent in cervical ectopy. sIgA antibodies against HPV16 capsids are generated in patients with cervical ectopy.
Rocha-Zavaleta
L
L
Department of Molecular Biology and Biotechnology, Institute of Biomedical Research, National University of Mexico, Mexico City, Mexico. lrochaz@servidor.unam.mx
Yescas
G
G
Cruz
R M
RM
Cruz-Talonia
F
F
D000328:Adult; D036022:Capsid Proteins / Q000276:immunology; D002582:Cervix Mucus / Q000276:immunology; D002584:Cervix Uteri / Q000473:pathology* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology; D030361:Papillomavirus Infections / Q000276:immunology / Q000473:pathology*; D012307:Risk Factors
D036022:Capsid Proteins; D004279:DNA, Viral; D007071:Immunoglobulin A, Secretory