Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis.
The design and parallel synthesis of potent, small molecule partial agonists of Neuromedin B receptor based on the 3-amino-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid amide core is described.
Shuttleworth
Stephen J
SJ
Department of Chemistry, Tularik Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.
Lizarzaburu
Mike E
ME
Chai
Anne
A
Coward
Peter
P
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D018004:Receptors, Bombesin / Q000819:agonists*; D013329:Structure-Activity Relationship
D007211:Indoles; C116775:PD 165929; D018004:Receptors, Bombesin