The Hummel-Dreyer method: impact in pharmacology.
Reviews devoted to drug-protein binding present mostly a variety of analytical methods applied to studying the unique process when the protein reversibly binds a low-molecular-weight substance-the drug. This report, however, reviews the great majority of papers presenting the application of one particular method introduced by Hummel and Dreyer in 1962: Measurement of protein-binding phenomena by gel filtration. The main criterion in reviewing published papers was the application of the Hummel-Dreyer method when the counterpart substances were the drug and the human plasma protein.
Soltés
Ladislav
L
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, SK-84104 Bratislava, Slovak Republic. exfasolt@savba.sk
D001798:Blood Proteins / Q000032:analysis* / Q000378:metabolism; D002853:Chromatography, Liquid / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D007700:Kinetics; D008074:Lipoproteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism
D001798:Blood Proteins; D008074:Lipoproteins; D004364:Pharmaceutical Preparations; D012709:Serum Albumin