title: High-dose methotrexate and asparaginase for the treatment of children with acute lymphoblastic leukemia: why and how?
authors.forename: Barton A
authors.initials: BA
authors.lastname: Kamen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001215:Asparaginase / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D001215:Asparaginase; D002955:Leucovorin; D008727:Methotrexate