Theoretical conformation of the closed and open states of the acetylcholine receptor channel.
We conduct a theoretical analysis to show the recently imaged structure of the acetylcholine receptor pore is in a non-conducting state. A hypothesised open state consistent with a lower resolution image is created and shown to have high conductance.
Corry
Ben
B
Department of Chemistry, University of Western Australia, Crawley, WA 6009, Australia. ben@theochem.uwa.edu.au
D003198:Computer Simulation; D015640:Ion Channel Gating; D007477:Ions / Q000737:chemistry / Q000378:metabolism; D008564:Membrane Potentials; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D011950:Receptors, Cholinergic / Q000737:chemistry* / Q000502:physiology*; D012964:Sodium / Q000737:chemistry / Q000378:metabolism; D055672:Static Electricity; D013816:Thermodynamics
D007477:Ions; D021122:Protein Subunits; D011950:Receptors, Cholinergic; D012964:Sodium