title: Secondary IgA nephropathy presenting as nephrotic syndrome with glomerular crescentic changes and acute renal failure in a patient with autoimmune hepatitis.
abstract: Patients with end-stage liver disease are prone to hemodynamic and immunologic renal injury, the latter at times manifesting as glomerulonephritis. Elevated serum immunoglobulin A (IgA) levels and mesangial IgG-IgA deposits are common in these patients, but are often clinically silent. We report a patient with autoimmune hepatitis and secondary IgA nephropathy (IgAN) who presented with nephrotic syndrome, acute renal failure (ARF), with 30% of the renal glomeruli having undergone crescentic change, and with IgA2 deposits in the glomerular mesangium. This article discusses secondary IgAN pathogenesis and its therapeutic management.
authors.affiliation: Division of Nephrology and Hypertension, Feimberg School of Medicine, Northwestern University, Chicago 60611, USA.
authors.forename: Naveen
authors.initials: N
authors.lastname: Singri
authors.forename: Briana
authors.initials: B
authors.lastname: Gleason
authors.forename: Steve L
authors.initials: SL
authors.lastname: Flamm
authors.forename: Yashpal S
authors.initials: YS
authors.lastname: Kanwar
authors.forename: Cybele
authors.initials: C
authors.lastname: Ghossein
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D005260:Female; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000628:therapy; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology