Kojic acid and its derivatives: history and present state of art.
Kojic acid (5-hydroxy-2-hydroxymethyl-4-pyranone) represents an attractive polyfunctional skeleton for development of biologically active compounds. The authors prepared a great variety of kojic acid derivatives and selected biological properties have been studied. Thus, kojic acid derivatives are promising compounds that might advantageously be used in human and/or veterinary medicine and also in preparation of new, even more biologically active preparations.
Brtko
J
J
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic. julius.brtko@savba.sk
Rondahl
L
L
Ficková
M
M
Hudecová
D
D
Eybl
V
V
Uher
M
M
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D011753:Pyrones / Q000737:chemistry* / Q000494:pharmacology*
D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011753:Pyrones; C011890:kojic acid