Acute appendicitis: comparison of low-dose and standard-dose unenhanced multi-detector row CT.
OBJECTIVE
To prospectively compare low- and standard-dose unenhanced multi-detector row computed tomography (CT) in patients suspected of having acute appendicitis.


METHODS
Ninety-five consecutive patients underwent two unenhanced multi-detector row CT examinations with 4 x 2.5-mm collimation, 120 kVp, and 30 and 100 effective mAs. Two radiologists independently read the images obtained at each dose during two sessions. Readers recorded visualization of the appendix and presence of gas in its lumen, appendicolith, periappendiceal fat stranding, cecal wall thickening, and abscess or phlegmon to measure the diameter of the appendix and to propose diagnosis (appendicitis or alternative). Data were compared according to dose and reader, with definite diagnosis established on basis of surgical findings (n = 37) or clinical follow-up. chi(2) tests and logistic regression were used. Measurement agreements were assessed with Cohen kappa statistics.


RESULTS
Twenty-nine patients had a definite diagnosis of appendicitis. No difference was observed between the frequency of visualization of the appendix (P =.874) neither in its mean diameter (P =.101-.696, according to readers and sessions) nor in the readers' overall diagnosis (P =.788) at each dose. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of each sign were not different between doses. Fat stranding, appendicolith, and diameter were the most predictive signs, regardless of dose, yielding approximately 90% of correct diagnoses. The ability to propose a correct alternative diagnosis was not influenced by the dose.


CONCLUSIONS
Low-dose unenhanced multi-detector row CT has similar diagnostic performance as standard-dose unenhanced multi-detector row CT for the diagnosis of acute appendicitis.
Keyzer
Caroline
C
Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Route de Lennik 808, B-1070 Brussels, Belgium.
Tack
Denis
D
de Maertelaer
Viviane
V
Bohy
Pascale
P
Gevenois
Pierre Alain
PA
Van Gansbeke
Daniel
D
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D001064:Appendicitis / Q000000981:diagnostic imaging*; D001065:Appendix / Q000000981:diagnostic imaging; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed