Hemophagocytic syndrome associated with antiepileptic drug.
An 8-year-3-month-old male with right porencephaly and epilepsy was found to have skin rash 2 weeks after the beginning of treatment with lamotrigine. One month later he suffered from impaired liver function and pancytopenia in the presence of hypocellular bone marrow with hemophagocytosis. No evidence of infection was evident. Intravenous immunoglobulin and steroid were administered with discontinuation of lamotrigine; the hemogram and liver function profile improved dramatically. Hemophagocytic syndrome should be considered a possible cause of pancytopenia in patients taking new antiepileptic drugs such as lamotrigine.
Yang
Yu-Chun
YC
Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Jou
Shiann-Tarng
ST
Chang
Yue-Hiang
YH
Liang
Jao-Shwann
JS
Lee
Wang-Tso
WT
D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood* / Q000139:chemically induced*; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D014227:Triazines / Q000009:adverse effects
D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine