title: Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients.
abstract: Dialysis patients show impaired responses to several vaccines. Limited recent data are available on influenza vaccination in these patients. In the 1998-1999 influenza season, 44 dialysis patients received a standard trivalent vaccination followed by a booster two months later. The serum antibody responses in these patients were compared with those found in healthy subjects. A fourfold rise in serum hemagglutination inhibition titre was achieved in 23-58% of all patients. Protective titres were reached in 53-93% of the patients. Since protective antibody titers can be induced, it is recommended to vaccinate dialysis patients annually against influenza.
authors.affiliation: Department of Internal medicine, Red Cross Hospital, The Hague, The Netherlands. n.vogtlander@aig.umcn.nl
authors.forename: N P J
authors.initials: NP
authors.lastname: Vogtländer
authors.forename: A
authors.initials: A
authors.lastname: Brown
authors.forename: R M
authors.initials: RM
authors.lastname: Valentijn
authors.forename: G F
authors.initials: GF
authors.lastname: Rimmelzwaan
authors.forename: A D M E
authors.initials: AD
authors.lastname: Osterhaus
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007117:Immunization, Secondary; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000276:immunology*; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines