title: [Comparative study of itraconazole and fluconazole therapy in vaginal candidosis].
abstract: Women who had symptomatic acute vulvovaginal candidiasis are include in this study. Micological investigation is realized by microscopy, culture method (CHROM agar, BD, USA) and ID 32 C (Fungus), Mini API Bio Merieux, France. Most frequent isolates are Candida albicans (82.67%), followed by C. glabrata (7.8%) and C. parapsilosis (5.51%). We compare two groups of patients: received itraconazole (200 mg bd oral dose for 1 day) and fluconazole (150 mg single oral dose). The rate of mycological cure is 93.8% in the itraconazole group and 79.03% in the fluconazole group (p = 0.008). Clinical response rate for women receiving itraconazole (80%) is significantly higher than fluconazole group (59.7%). These results suggests that itraconazole is more effective than fluconazole in the treatment of acute vulvovaginal candidiasis.
authors.affiliation: Department of Microbiology and Virology, Department of General and Oncological Gynecology, Military Medical Academy-Sofia.
authors.forename: R
authors.initials: R
authors.lastname: Vacheva-Dobrevski
authors.forename: S
authors.initials: S
authors.lastname: Kovachev
authors.forename: A
authors.initials: A
authors.lastname: Nacheva
authors.forename: S
authors.initials: S
authors.lastname: Stoev
authors.forename: N
authors.initials: N
authors.lastname: Vasilev
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D015725:Fluconazole