[Effect of Kampo medicines on the peripheral blood flow rate of betamethason-induced Oketsu syndrome mice by laser Doppler flow meter].
Stagnation of peripheral blood flow is the cause of various diseases. Changes in peripheral blood flow after oral administration of Kampo medicines in mice with betamethasone-induced oketsu syndrome and normal mice were examined using a laser Doppler blood flow meter. The Kampo medicines used were: Toki-shakuyaku-san; Kami-shoyo-san; Keishi-bukuryo-gan; Daio-botanpi-to; Tokaku-joki-to; Goshuyu-to; and Hange-koboku-to. In the oketsu mice, blood flow was improved by single-dose administration of Toki-shakuyaku-san, Kami-shoyo-san, Keishi-bukuryo-gan, Daio-botanpi-to, Tokaku-joki-to, and Goshuyu-to, but only Toki-shakuyaku-san increased blood flow significantly in normal mice. In addition, blood flow decreased after single-dose administration of Keishi-bukuryo-gan, Daio-botanpi-to, and Tokaku-joki-to in normal mice.
Ueda
Joji
J
Department of Phytochemistry, Tohoku Pharmaceutical University, Sendai, Japan.
Ohya
Etsuko
E
Udagawa
Kozue
K
Hara
Akiko
A
Fukui
Mai
M
Yamagishi
Hirokazu
H
Nakazawa
Takahiro
T
Yasuda
Takaaki
T
Ohsawa
Keisuke
K
D000818:Animals; D001623:Betamethasone; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000503:physiopathology*; D001783:Blood Flow Velocity; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D017078:Laser-Doppler Flowmetry / Q000295:instrumentation*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008833:Microcirculation / Q000187:drug effects* / Q000503:physiopathology; D013268:Stimulation, Chemical; D013577:Syndrome
D004365:Drugs, Chinese Herbal; D001623:Betamethasone