title: The EEG profile of patients with uncontrolled vs. controlled seizures.
abstract: The goal of this study was to provide an EEG profile of patients (150) with uncontrolled (U) seizures, in contrast with those (150) with controlled (C) attacks. In the U group 804 EEGs were done and in the C group 674 were performed, all with both waking and sleep recordings; the range of EEG records on a given patient was 2-23. The number of spikes and the amount of abnormal slowing was quantified in each record. Two different peaks of age were evident, appearing at 10-19 yrs and 40-49 yrs. The number of patients with a spike discharge on the first EEG was 64% in the C and 92% in the U group with an increasing incidence to 83% (C) and 100% (U) in later records. If spikes were absent in the first EEG in the C group, the majority showed only rare discharges later. The spike profile of the U patient initially was that 1/2 showed a typical number of spikes and nearly 1/2 many or very many spikes. Over time a decrease was seen in those with many-very many discharges, resulting in an increase with a typical number. Still later, a reversal occurred in the U patients with an increasing number with many or very many spikes. The slow wave profile of the U patient was that 2/3 showed some abnormal slow waves on the first record, increasing to 100% in later records. The increase was from delta, not theta activity. The spike profile of the C patient was that a typical number of spikes was seen at first in nearly 1/2, but only a small minority showed many-very many discharges. The slow wave profile for the C patient was that theta, not delta waves, increased in time. The (median) time between a unilateral spike discharge to a bilateral discharge was 4-5 yrs, and the U group much more often than the C group showed this change to bilateral spikes. The time between unilateral to bilateral slow waves varied between 4-9 yrs.
authors.affiliation: Epilepsy Clinic, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Hughes
authors.forename: John J
authors.initials: JJ
authors.lastname: Fino
authors.forename: Yevgenya
authors.initials: Y
authors.lastname: Kaydanova
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology*