[Effect of Chinese herbal treatment on the efficiency of blocking CD antigen and on prolactin and progesterone in women with recurrent spontaneous abortion].
OBJECTIVE
To explore the effect of Chinese herbal medicine Baotai Granule (BTG, a self-made preparation) on CD antigen blocking efficiency, prolactin (PRL) and progesterone (P) in patients with recurrent spontaneous abortion (RSA).


METHODS
Thirty-four women suffered from RSA were treated with BTG, twice every day, 1 package (10 g) in each time by orally intake. Changes of the efficiency of serum blocking antibody in them to the CD antigen in their husband's peripheral T-lymphocytes before and after treatment were observed. And the changes of blood levels of PRL and P were also monitored.


RESULTS
Fetus had successfully protected in 30 women (88.2%), in them, the efficiency of blocking to CD3, CD4 and CD8 after treatment were all higher than that before treatment, and levels of PRL and P in peripheral blood increased along with the increase of gestational age, while no obvious change was found in those who failed to complete pregnancy.


CONCLUSIONS
Chinese herbal medicine could protect the fetus by regulating the response between endocrine and immunity network during pregnancy.
Zhang
Jian-feng
JF
Affiliated Hospital of Obstetrics and Gynecology, Fudan University, Shanghai 200011.
Gui
Sui-qi
SQ
D000026:Abortion, Habitual / Q000188:drug therapy* / Q000276:immunology; D000328:Adult; D019138:Antibodies, Blocking / Q000187:drug effects; D015703:Antigens, CD / Q000187:drug effects* / Q000276:immunology; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008517:Phytotherapy; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology
D019138:Antibodies, Blocking; D015703:Antigens, CD; D004365:Drugs, Chinese Herbal; D011374:Progesterone; D011388:Prolactin