[Effects of perindopril on plasma soluble TRAIL and receptor soluble DR5 in patients with congestive heart failure].
OBJECTIVE
To explore the levels of soluble TRAIL and DR5 in plasma of patients with congestive heart failure (CHF) and the effects of perindopril.


METHODS
58 CHF patients were randomly divided into two groups, namely perindopril treatment group (30 cases) and routine treatment group (28 cases). The levels of sTRAIL and sDR5 in plasma of 30 CHF patients treated with perindopril, 28 CHF patients treated with routine method before and after treatment and 20 healthy persons were detected by ELISA.


RESULTS
(1)The mean levels of sTRAIL in plasma of 58 CHF patients and 20 healthy persons were (1.43+/-0.47) microg/L and (0.93+/-0.12) microg/L, respectively, the comparison between the patients and healthy persons had no notable difference (P>0.05), suggesting that plasma sTRAIL level had no significant relation to injured level of cardiac function. As for sDR5 level, the mean level in plasma of 58 CHF patients was (39.67+/-6.78) ng/L, this value was significantly higher than that of healthy control group, and the level of sDR5 was increased with the injured level of cardic function.(2)The plasma levels of sTRAIL in both perindopril group and conventional treatment group decreased after treatment, but there was no significant difference. The mean levels of plasma sDR5 in perindopril group were (31.23+/-10.16 ) ng/L and (8.50+/-2.14) ng/L; the levels in conventional group (48.81+/-8.74) ng/L and (26.64+/-6.27) ng/L, respectively, the perindopril group was lower than the conventional group descending rates were 72.7% and 45.3% respectively.(3)The level of plasma sDR5 in CHF patients resulting from hypertensive cardiopathy was much higher than that in CHF patients resulting from any other etiological factors.


CONCLUSIONS
DR5 may play an important role in the occurrence and progress of myocardium apoptosis of CHF patients. Perindopril can down-regulate the level of plasma sDR5, therefore, it may have the great effect on retarding course of ventricular remodeling, protecting and improving cardial function of CHF patients.
Hong
Yan
Y
Department of Geriatrics, Xijing Hospital,Fourth Military Medical University, Xi'an 710032,China.
Li
Yuan
Y
Wang
Xiao-Ming
XM
Liu
Xue-Song
XS
Li
Ying-Na
YN
Ouyang
Wei-Ming
WM
Chen
Chang-Sheng
CS
Jin
Bo-Quan
BQ
D017209:Apoptosis / Q000187:drug effects; D006333:Heart Failure / Q000097:blood; D006801:Humans; D020913:Perindopril; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D020257:Ventricular Remodeling
D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D020913:Perindopril