[Relationship between the data from MR-diffusion tensor imaging and the clinical cognitive evaluation in Alzheimer's disease].
OBJECTIVE
To determine the relationship between the extent of the damage and clinical data in Alzheimer's disease (AD).


METHODS
Twenty-two patients with AD and twenty-two controls received MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter in AD patients were measured respectively in parietal lobe and the genu of corpus callosum. Independent-samples t-test for non-paired data was used to test differences between AD and controls for FA values. Correlation analysis was applied to reveal the correlations between FA values in each region and the MMSE, FOM, RVR, BD and DS scores.


RESULTS
Positive correlations were found between FA values in left parietal lobe and FOM/DS, and between FA values in genu of corpus callosum and MMSE scores.


CONCLUSIONS
In AD, the MR-DTI can reflect the relationship between the degree of white matter abnormalities and the cognitive impairment.
Sun
Ye
Y
Department of Radiology, People's Hospital, Peking University, Beijing 100044, China. lily_sunye@yahoo.com
Du
Xiang-ke
XK
Zhang
Zhen-xin
ZX
Chen
Xia
X
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000473:pathology / Q000523:psychology; D016880:Anisotropy; D002540:Cerebral Cortex / Q000473:pathology*; D003071:Cognition; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014888:Wechsler Scales