title: Protective ventilation of patients with acute respiratory distress syndrome.
abstract: In a recent issue of the British Journal of Anaesthesia, Moloney and Griffiths reviewed clinically pertinent issues surrounding the management of the acute respiratory distress syndrome (ARDS) patient, particularly as it pertains to the treatment of ventilator induced/associated lung injury (VILI). In addition to highlighting the important observations that have contributed to further our understanding of the relationship between the mechanical ventilator and inflammatory lung injury, the authors also offer a concise reappraisal of the clinical strategies used to minimize VILI in ARDS. Special emphasis is placed on the theory of biotrauma, which attempts to explain how multi-organ failure may develop in patients who ultimately succumb to this syndrome.
authors.affiliation: Interdepartmental Division of Critical Care Medicine, and Department of Medicine, University of Toronto, Toronto, Canada.
authors.forename: Claudia C
authors.initials: CC
authors.lastname: dos Santos
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Slutsky
mesh_terms: D001469:Barotrauma / Q000209:etiology; D006801:Humans; D055370:Lung Injury; D009102:Multiple Organ Failure / Q000209:etiology / Q000503:physiopathology; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*