The ideal lavage volume for removing bradykinin, interleukin-6, and protein from the temporomandibular joint by arthrocentesis.
OBJECTIVE
The aim of this study was to investigate the ideal volume of perfusate for arthrocentesis of the temporomandibular joint (TMJ) disorders (TMDs).


METHODS
We evaluated 17 joints in 17 patients with TMD in this study. Arthrocentesis of the TMJ was done by perfusion of 400 mL of Ringer's solution. The first 5 mL of perfusate was collected, and then a 5-mL sample was collected when the total volume of perfusate outflow approached 50, 100, 200, 300, and 400 mL. The concentrations of bradykinin, interleukin-6, and protein were measured by immunoassay.


RESULTS
The concentration of bradykinin, interleukin-6, and protein during arthrocentesis were effectively reduced by more than 200 mL of lavage (P <.05). With a perfusate volume of 300 to 400 mL, the protein and bradykinin were no longer detectable.


CONCLUSIONS
Arthrocentesis is effective for washing out bradykinin, interleukin-6, and protein from the TMJ, and the ideal lavage volume of perfusate for arthrocentesis is between 300 and 400 mL.
Kaneyama
Keiseki
K
Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa, Japan. k-k@kanazawa-med.ac.jp
Segami
Natsuki
N
Nishimura
Masaaki
M
Sato
Jun
J
Fujimura
Kazuma
K
Yoshimura
Hiroshi
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001920:Bradykinin / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000378:metabolism*; D019152:Paracentesis / Q000379:methods*; D011506:Proteins / Q000378:metabolism; D013582:Synovial Fluid / Q000378:metabolism; D013705:Temporomandibular Joint Disorders / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D007507:Therapeutic Irrigation / Q000379:methods*; D016896:Treatment Outcome
D018836:Inflammation Mediators; D015850:Interleukin-6; D011506:Proteins; D001920:Bradykinin