A novel mixed-ligand antimycobacterial dimeric copper complex of ciprofloxacin and phenanthroline.
A novel mixed-ligand Cu(II) complex of ciprofloxacin (cfH) and phenanthroline, is found to crystallize as a dimeric moiety containing monocationic and dicationic species. Two such dimeric moieties are found in the same unit cell leading to a dicationic cluster. The higher negative redox potential for this cluster dampens its antimycobacterial activity against M. smegmatis.
Saha
Dilip Kumar
DK
Department of Chemistry, University of Pune, Pune 411007, India.
Sandbhor
Uday
U
Shirisha
K
K
Padhye
Subhash
S
Deobagkar
Dileep
D
Anson
Christopher E
CE
Powell
Annie K
AK
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D020102:Mycobacterium smegmatis / Q000187:drug effects / Q000254:growth & development; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008024:Ligands; D010618:Phenanthrolines; D002939:Ciprofloxacin; D003300:Copper