title: Should selective serotonin reuptake inhibitors be prescribed to all patients with ischemic heart disease?
abstract: Recent studies have uncovered more and more evidence demonstrating the adverse relationship between depression and ischemic heart disease. One of the most significant mechanisms that may explain the adverse relationship is the increased platelet activity, otherwise known as aggregation, observed to occur in patients with depression or ischemic heart disease. Platelet activity is further elevated in patients with depression and ischemic heart disease. Selective serotonin reuptake inhibitors are antidepressants and also act like platelet inhibitors. The results of large-scale clinical trials suggest that the use of selective serotonin reuptake inhibitors may reduce cardiac events in post-myocardial infarction patients or in those with unstable angina that may be related to the effects of selective serotonin reuptake inhibitors on platelet aggregation.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Department of Medicine, Duke University Medical Center, PO Box 3366, Durham, NC 27710, USA. jiang001@mc.duke.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Ranga R
authors.initials: RR
authors.lastname: Krishnan
mesh_terms: D000789:Angina, Unstable / Q000150:complications / Q000188:drug therapy; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003863:Depression / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D011307:Drug Prescriptions / Q000592:standards; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D010974:Platelet Aggregation / Q000187:drug effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017367:Selective Serotonin Reuptake Inhibitors