[The change of renin, endothelin and prostaglandin in blood during long time left ventricular assist].
OBJECTIVE
To monitor the change of renin, endothelin and 6-keto-prostaglandin F1alpha in canine during left ventricular assist (LVA).


METHODS
Eight canines were assisted by left assist ventricular device for 9 hours. The level of renin, endothelin and 6-keto-prostaglandin f1alpha in plasma were measured by radioimmunity analysis before assisting (control group) and at 3 hours, at 6 hours, at 9 hours after assisting.


RESULTS
The level of endothelin in plasma didn't dropped remarkably as LVA proceeded in which there was not differency in statistical diffency compared with control group[(51 +/- 11) ng/L, (42 +/- 8) ng/L, t = 0.926, P > 0.05]; The level of renin in plasma reached the summit at 3 hours during LVA compared with control group (3,036 +/- 1,411) ng/L, (1,783 +/- 467) ng/L, t = 5.013, P < 0.01) and later show dropping tendency without statistical differency at 9 hours (1 944 +/- 883) ng/L (t = 0.644, P > 0.05); The level of 6-keto-prostaglandin f1alpha in plasma at 3 hours during assisting increased remarkably [(75 +/- 17) ng/L, t = 1.411, P < 0.05), at 6 hours reached summit [(92 +/- 18)ng/L, t = 3.533, P < 0.01) and at 9 hours show dropping tendency with significant differency compared with control group (90 +/- 22) ng/L, t = 2.516, P < 0.05).


CONCLUSIONS
During 9 hours LVA, endothelin didn't dropped remarkably compared with control group and the endothelium released renin with transient increase, prostaglandin with consistent increase.
Tong
Lian-wei
LW
Department of Thoracic and Cardiovascular Surgery, Guangzhou Municipal Red Cross Hospital affiliated to JiNan University Medical College, Guangzhou 510220, China.
Ren
Bing
B
Zhu
Xiao-dong
XD
D000818:Animals; D004285:Dogs; D016232:Endothelins / Q000097:blood*; D006353:Heart-Assist Devices; D023421:Models, Animal; D011453:Prostaglandins / Q000097:blood*; D012083:Renin / Q000097:blood*; D016276:Ventricular Function
D016232:Endothelins; D011453:Prostaglandins; D012083:Renin