title: Genome-wide scan for type 2 diabetes loci in Hong Kong Chinese and confirmation of a susceptibility locus on chromosome 1q21-q25.
abstract: We conducted an autosomal genome scan to map loci for type 2 diabetes in a Hong Kong Chinese population. We studied 64 families, segregating type 2 diabetes, of which 57 had at least one member with an age at diagnosis of </=40 years. These families included a total of 126 affected sibpairs and 4 other affected relative pairs. Nonparametric linkage analysis revealed seven regions showing nominal evidence for linkage with type 2 diabetes (logarithm of odds [LOD] >0.59, P(pointwise) < 0.05): chromosome 1 at 173.9 cM (LOD = 3.09), chromosome 3 at 26.3 cM (LOD = 1.27), chromosome 4 at 135.3 cM (LOD = 2.63), chromosome 5 at 139.3 cM (LOD = 0.84), chromosome 6 at 178.9 cM (LOD = 1.91), chromosome 12 at 48.7 cM (LOD = 1.99), and chromosome 18 at 28.1 cM (LOD = 1.00). Simulation studies showed genome-wide significant evidence for linkage of the chromosome 1 region (P(genome-wide) = 0.036). We have confirmed the results of previous studies for the presence of a susceptibility locus on chromosome 1q21-q25 (173.9 cM) and suggest the locations of other loci that may contribute to the development of type 2 diabetes in Hong Kong Chinese.
authors.affiliation: Howard Hughes Medical Institute, University of Chicago, 5841 S. Maryland Ave., MC1028, Chicago, IL 60637, USA. maggieng@uchicago.edu
authors.forename: Maggie C Y
authors.initials: MC
authors.lastname: Ng
authors.forename: Wing-Yee
authors.initials: WY
authors.lastname: So
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.forename: Vincent K L
authors.initials: VK
authors.lastname: Lam
authors.forename: Clive S
authors.initials: CS
authors.lastname: Cockram
authors.forename: Julian A J H
authors.initials: JA
authors.lastname: Critchley
authors.forename: Graeme I
authors.initials: GI
authors.lastname: Bell
authors.forename: Juliana C N
authors.initials: JC
authors.lastname: Chan
mesh_terms: D044466:Asian People / Q000235:genetics*; D002874:Chromosome Mapping; D020090:Chromosome Segregation; D002878:Chromosomes, Human, Pair 1; D003198:Computer Simulation; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006723:Hong Kong; D006801:Humans; D008126:Lod Score