title: Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans.
abstract: Association studies of the serotonin transporter (SLC6A4) gene in obsessive-compulsive disorder (OCD) have generated discrepant results. Here, we genotyped the 5-HTTLPR polymorphism in 106 French OCD patients and 171 healthy controls (case control study). We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study.
authors.affiliation: University Department of Psychiatry, INSERM E0 117, Sainte-Anne Hospital, Paris, France. chabane@im3.inserm.fr
authors.forename: Nadia
authors.initials: N
authors.lastname: Chabane
authors.forename: Bruno
authors.initials: B
authors.lastname: Millet
authors.forename: Richard
authors.initials: R
authors.lastname: Delorme
authors.forename: Dirk
authors.initials: D
authors.lastname: Lichtermann
authors.forename: Flavie
authors.initials: F
authors.lastname: Mathieu
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Laplanche
authors.forename: Isabelle
authors.initials: I
authors.lastname: Roy
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Mouren
authors.forename: Regis
authors.initials: R
authors.lastname: Hankard
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Jean Marie
authors.initials: JM
authors.lastname: Launay
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
mesh_terms: D000328:Adult; D017668:Age of Onset; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005192:Family Health; D005260:Female; D005602:France / Q000453:epidemiology; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D050486:Serotonin Plasma Membrane Transport Proteins; D044465:White People / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins