title: Disease modification in Parkinson's disease.
abstract: Several separate gene mutations have now been identified in familial Parkinson's disease and important environmental influences modulating risk for the idiopathic form of the disease have also been recognised. These insights have provided important clues in the development of disease modifying therapies. Some compounds have already been shown to potentially delay disease progression in early clinical trials. The most important challenge, particularly for those drugs that might have a symptomatic effect, is defining appropriate markers that will confirm a neuroprotective effect.
authors.affiliation: Royal Free and University College Medical School and the Institute of Neurology, University College London, UK. schapira@rfc.ucl.ac.uk
authors.forename: Anthony H V
authors.initials: AH
authors.lastname: Schapira
mesh_terms: D000978:Antiparkinson Agents / Q000494:pharmacology*; D015415:Biomarkers / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D051843:Synucleins; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D015415:Biomarkers; D016166:Free Radical Scavengers; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D051843:Synucleins