title: Hyperthyroidism six years post-BMT for acute myeloblastic leukemia in a patient on long-term lithium therapy for bipolar affective disorder.
abstract: Lithium is commonly used to treat bipolar affective disorder. It is well known to adversely affect thyroid function, most commonly causing hypothyroidism. Hyperthyroidism is a rare complication. Similarly, total body irradiation (TBI) associated with BMT is well known to affect thyroid function frequently causing hypothyroidism. Hyperthyroidism secondary to TBI is unusual. To have both a history of chronic lithium therapy and TBI with a BMT in patient presenting with hyperthyroidism is an extremely atypical situation. We describe a 39-year-old male who presented with primary hyperthyroidism after 18 years of lithium use for bipolar affective disorder and 6 years post-BMT for AML-M4.
authors.affiliation: Division of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, ON, Canada.
authors.forename: Angeline
authors.initials: A
authors.lastname: Law
authors.forename: Joshua
authors.initials: J
authors.lastname: Rifkind
authors.forename: Fred
authors.initials: F
authors.lastname: Rosen
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Lipton
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000150:complications* / Q000188:drug therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications* / Q000628:therapy; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D013972:Thyrotropin / Q000097:blood; D014916:Whole-Body Irradiation / Q000009:adverse effects
chemical_list: D013972:Thyrotropin; D008094:Lithium