The first synthesis of glucosylgalactosyl hydroxylysine (Glu-Gal-Hyl), an important biological indicator of collagen turnover.
This paper reports the first chemical synthesis of alpha-D-glucopyranosyl-(1-->2)-beta-D-galactopyranosyl-O-hydroxylysine, a glycoside of hydroxylysine important as indicator of skin and bone collagen turnover, starting with commercial compounds.
Allevi
Pietro
P
Dipartimento di Medicina, Chirurgia e Odontoiatria, Università di Milano, via A. Di Rudinì 8, I-20142 Milano, Italy. pietro.allevi@unimi.it
Anastasia
Mario
M
Paroni
Rita
R
Ragusa
Andrea
A
D003094:Collagen / Q000378:metabolism*; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism*
D006901:Hydroxylysine; C001295:glucosylgalactosylhydroxylysine; D003094:Collagen