[Verapamil enhancement of antitumor activity of mitoxantrone on ACC-22 cells in citro]
The combined effect of verapamil and DHAD on the growth of human adenoid cystic carcinoma cell line(ACC-2) in vitro was investigated.In combination, VP and DHAD had synergistic inhibitory effect.VP enhanced the cytotoxicity of DHAD in ACC-2 cells and significantly inhibited the cell proliferation.VP also potentiated the inhibitory effect of DHAD on colongenic ability of ACC-2 cell,suggesting it enhance the cytocidal effect of DHAD on human adenoid cystic carcinoma.
Chen
J W
JW
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Second Medical University. Shanghai 200011,China.
Qiu
W L
WL
He
R G
RG
Lin
G C
GC