[Tumor antigen-specific cytotoxic T lymphocytes and cancer immunotherapy - review].
Tumor antigen-specific cytotoxic T lymphocytes are important anti-cancer cells. The focuses of this review are to introduce the molecular basis of antigen presentation and CTL recognition, to summarize the identification of tumor associated antigens and their T cell epitopes, to highlight the current insights into the immunogenicity of TAA peptides and the principles of peptide-based vaccines against cancer, and to comment on future prospects for CTL therapy.
Liu
Ying
Y
Department of Pediatric Internal Medicine, General Hospital of PLA, Beijing 100853, China.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines