[Metabolic syndrome strongly linked to stroke in Chinese].
OBJECTIVE
To assess the association of the metabolic syndrome with stroke in Chinese using the definition of ATP III, and revised definition according to Chinese criteria for abdominal obesity.


METHODS
Multi-center case control study, 1934 first-ever-stroke patients (Atherothrombosis, lacunar infarction, and intracerebral hemorrhage) aged 30 to 74 years were sequentially recruited. And 1839 age, gender and geographically matched subjects were included as controls.


RESULTS
The prevalence of metabolic syndrome defined by either ATP III or Chinese criteria was significantly increasing in patients with lacunar infarction, cerebral atherosclerosis, or intracerebral hemorrhage than control subjects. After age- and sex-adjusted and further adjusted age, sex, total cholesterol, smoking, drinking, and education levels, the metabolic syndrome defined by ATP III criteria was associated with a 2.7 to 4.3 fold and 2.5 to 4.0 fold higher risk of the three stroke subtypes, respectively.


CONCLUSIONS
the metabolic syndrome defined by ATP III and revised according to Chinese criteria of abdominal obesity was positively associated with the risk of stroke in our case control study. This study underscores the need for well-designed prospective study in Chinese to give further evidence to the link between metabolic syndrome and stroke.
Dou
Xiang-feng
XF
Sino-German Lab for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Science, Beijing 100037, China. douxiangfeng@yahoo.com.cn
Zhang
Hong-ye
HY
Sun
Kai
K
Wang
Dao-wen
DW
Liao
Yu-hua
YH
Ma
Ai-qun
AQ
Zhu
Zhi-ming
ZM
Zhao
Bing-rang
BR
Zhao
Ji-zong
JZ
Hui
Ru-tai
RT
D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000150:complications / Q000453:epidemiology*