Acute leukemia with natural killer cells antigens in Brazilian children.
Malignancies arising from Natural Killer cells (NK) were described mainly comprising disorders related to large granular lymphocyte expansion. Clinical, morphological and immunophenotypic characteristics of myeloid/NK cell precursor acute leukemia (M/NK-AL) have been mainly described in adult patients. We identified nine children with M/NK-AL precursor cells in a series of 264 childhood acute leukemia diagnosed in our laboratory from consecutive referrals before treatment. CD34 +/-, CD13/33 +, CD11b +, a-MPO + and CD56 +, characterized these cases with TcR alphabeta and gammadelta negative cells. The differential diagnosis between subtypes of NK leukemia with those of lymphoid or myeloid origin in childhood raises the question regarding the pathogenesis and therapeutic implications of this rare entity in children.
Pombo-de-Oliveira
Maria S
MS
Division of Experimental Medicine and Cytogenetic Laboratory, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. mpombo@inca.gov.br
Campos
Mércia Mendes
MM
Bossa
Yomayra Elena
YE
Alencar
Dora Maria
DM
Curvello
Cynthia
C
Agudelo
Diana Patrícia
DP
Mendonça
Núbia
N
Pereira
Edinalva
E
Macedo-Silva
Maria L
ML
D000208:Acute Disease; D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D001938:Brazil; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D007938:Leukemia / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D007951:Leukemia, Myeloid / Q000145:classification / Q000175:diagnosis / Q000276:immunology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000175:diagnosis / Q000276:immunology
D015703:Antigens, CD; D000951:Antigens, Neoplasm