[Effect of biological preparation alfetin in infiltrative pulmonary tuberculosis].
The authors evaluated influence of Alfetin new Russian biologic preparation on pulmonary surfactant system and phospholipid metabolism in workers at risk of occupational pneumoconiosis, who suffer from infiltrative pulmonary tuberculosis. Considering positive changes in serum phospholipids subunits under alfetin treatment, the authors proved membrane protective effect of the drug. Alfetin was proved to weaken toxic effects of tuberculostatic drugs on lung surfactant.
Cherkasov
V A
VA
Permiakova
N V
NV
Maliutina
N N
NN
Peleneva
I M
IM
Rodionov
S Iu
SIu
D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000188:drug therapy* / Q000378:metabolism; D010743:Phospholipids / Q000097:blood; D011663:Pulmonary Surfactants / Q000378:metabolism; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000008:administration & dosage / Q000627:therapeutic use*
D010743:Phospholipids; D011663:Pulmonary Surfactants; D000509:alpha-Fetoproteins