Role of infiltrated leucocytes in tumour growth and spread.
Leucocytes are a major component of the tumour microenvironment. Recent studies have indicated that the infiltration and activity of these host cells are regulated by the tumour to promote its survival and progression. Through the production of an array of growth factors, proteases and angiogenic mediators, leucocytes in the tumour microenvironment promote tumour growth, angiogenesis and metastasis.
Lin
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Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women's Health,Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA.
Pollard
J W
JW
D018450:Disease Progression; D010450:Endopeptidases / Q000096:biosynthesis / Q000494:pharmacology; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000503:physiopathology*; D009389:Neovascularization, Pathologic
D010450:Endopeptidases