title: [Homocysteine: why is it harmful?].
abstract: This paper discusses the potential pathogenetic mechanisms by which the damaging action of hyperhomocysteinemia on the vessels is realized, namely a negative effect on the structure and function of the vessel wall, on proliferation of smooth muscle cells and endothelium-dependent vasodilatation; on the processes of blood cell interaction with the vessel wall (adhesion of monocytes, platelet adhesion and aggregation, etc): prothrombogenic action on the coagulation system, and effect of homocysteine on adenosine concentration in plasma and tissues.
authors.affiliation: Laboratory for Clinical Problems of Atherosclerosis, A. L. Myasnikov Institute of Clinical Cardiology, Russian Scientific Cardiology Complex, RF Ministry of Public Health, Moscow, Russia.
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Kagan-Ponomarev
mesh_terms: D000241:Adenosine / Q000172:deficiency / Q000627:therapeutic use; D005492:Folic Acid / Q000627:therapeutic use; D006712:Homocystinuria / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D014803:Vitamin B Complex; D005492:Folic Acid; D000241:Adenosine