title: Impact of age on the outcome of liver resections.
abstract: The purpose of this study was to evaluate the influence of age on the outcome of liver resections. One hundred five consecutive hepatic resections were divided into two groups: > or = 65 years old [old group (O-group)] and < 65 years old [young group (Y-group)]. The two groups were first compared to evaluate the distribution of the variables potentially affecting the postoperative course, including primary diagnosis, concomitant diseases, previous upper abdominal surgery, type of operation (major or minor resection), associated procedures, presence and length of portal clamping, intraoperative blood losses and transfusions, and length of operation. The outcome of hepatic resections in the two groups was comparatively evaluated in terms of postoperative mortality, morbidity, transfusions, and length of postoperative hospitalization. The Y-group included 61 resections in 60 patients, mean age 52 +/- 10 years (mean +/- SD), range 23-64 years, whereas the O-group included 44 resections in 43 patients, mean age 71 +/- 4 years (mean +/- SD ), range 65-82 years. The O-group included more hepatocellular carcinomas (45.4% vs 18.0%, P = 0.002) and chronic liver diseases (40.9% vs 18.7%, P = 0.017); the median length of operation was slightly higher in the Y-group (300 minutes vs 270 minutes, P = 0.003). Both O-group and Y-group were comparable (P = n.s.) when evaluated for all other listed variables. As far as concerns the outcome of hepatic resections in the two groups, the length of postoperative hospitalization was identical (median 9 days, 5-60 days), whereas transfusions of packed red cells (O-group vs Y-group: 25.0% vs 16.3%, P = 0.30) or fresh frozen plasma (O-group vs Y-group: 13.6% vs 6.5%, P = 0.053) were not statistically different. Postoperative mortality included one case among young patients whereas no deaths were recorded among elderly patients. Postoperative morbidity was higher in Y-group than in O-group (31.5% vs 20.5%, P = 0.59). The age factor does not negatively affect the outcome of liver resections.
authors.affiliation: Department of Surgery, Scientific Institute San Raffaele Hospital, Vita-Salute San Raffaele University School of Medicine, 20132 Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Aldrighetti
authors.forename: Marcella
authors.initials: M
authors.lastname: Arru
authors.forename: Giliola
authors.initials: G
authors.lastname: Calori
authors.forename: Roberto
authors.initials: R
authors.lastname: Caterini
authors.forename: Laura
authors.initials: L
authors.lastname: Comotti
authors.forename: Giorgio
authors.initials: G
authors.lastname: Torri
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Ferla
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016063:Blood Loss, Surgical; D001803:Blood Transfusion / Q000706:statistics & numerical data; D003250:Constriction; D000075202:Contraindications; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods / Q000401:mortality*; D006785:Hospitals, University; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007902:Length of Stay / Q000706:statistics & numerical data; D008107:Liver Diseases / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D018579:Patient Selection; D011169:Portal Vein / Q000601:surgery; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome