Anticholinergic drugs--functional antidotes for the treatment of tabun intoxication.
1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50). The efficacy of choice antidotal treatment consisting of acetylcholinesterase reactivator obidoxime and one of four anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) was compared. 2. Testing of tabun-induced neurotoxicity progress was carried out using the method Functional observational battery. The experimental animals as well as controls were observed at 24 hours and 7 days following tabun or saline administration. 3. The results were compared to the condition of animals without anticholinergic drug (oxime alone) and control rats that received physiological solution instead of tabun and treatment. Antidotal treatment involving centrally acting anticholinergic drugs (benactyzine, biperiden, scopolamine) showed significantly higher neuroprotective efficacy compared to antidotal treatment containing atropine.
Krejcová
Gabriela
G
Department of Toxicology, Purkynĕ Military Medical Academy in Hradec Králové, Czech Republic. krejcova@pmfhk.cz
Kassa
Jirí
J
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D008297:Male; D009768:Obidoxime Chloride / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D010755:Organophosphates; D051381:Rats; D017208:Rats, Wistar
D000931:Antidotes; D002619:Chemical Warfare Agents; D018680:Cholinergic Antagonists; D002801:Cholinesterase Reactivators; D010755:Organophosphates; D009768:Obidoxime Chloride; C009374:tabun