In vitro activity of OPT-80 against Clostridium difficile.
Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.
Ackermann
Grit
G
Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstrasse 24, 04103 Leipzig, Germany. ackermg@medizin.uni-leipzig.de
Löffler
Birgit
B
Adler
Daniela
D
Rodloff
Arne C
AC
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects; D016360:Clostridioides difficile / Q000187:drug effects*; D003015:Clostridium Infections / Q000382:microbiology; D003470:Culture Media; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D003470:Culture Media; D006027:Glycosides; C487655:OPT 80