[Intestinal permeability of patients with advanced digestive tract malignant tumors].
OBJECTIVE
To assess the intestinal barrier function of patients with advanced digestive tract malignant tumors by measuring the changes in intestinal permeability.


METHODS
Sixteen patients with digestive tract tumors and 16 healthy volunteers were enrolled. After oral administration of mannitol and lactulose in deionized water, the 6-hour urine samples were collected for analyzing mannitol and lactulose concentrations using gas-liquid chromatography.


RESULTS
Urine lactulose concentration and lactulose/mannitol (L/M) ratio of the tumor patients were increased in comparison with those of the healthy subjects (P<0.05).


CONCLUSIONS
he intestinal permeability increased in these tumor patients, indicating intestinal barrier dysfunction.
Yao
Yu-chuan
YC
Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. yaoge1972@163.com
Chen
Cun-long
CL
Wang
Ji-de
JD
Zhang
Ya-li
YL
Jiang
Bo
B
Xiong
De-xin
DX
D000368:Aged; D000369:Aged, 80 and over; D002849:Chromatography, Gas; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007792:Lactulose / Q000652:urine; D008297:Male; D008353:Mannitol / Q000652:urine; D008875:Middle Aged; D010539:Permeability
D008353:Mannitol; D007792:Lactulose