[The significance of fluorescent patterns of antineutrophil cytoplasmic antibodies (ANCA) in renal diseases].
OBJECTIVE
To further explore significance of fluorescent patterns of antineutrophil cytoplasmic antibodies in renal diseases.


METHODS
ANCA fluorescent patterns and its target antigens in sera of 251 patients with renal diseases were detected by indirect immunofluorescence (IIF) and ELISA.


RESULTS
The positive percentage of ANCA is 20.3% (51/251), in which 3.98%(10/251) is cANCA, 11.95% (30/251) pANCA and 4.38%(11/251) aANCA.


CONCLUSIONS
The simultaneous screening for ANCA and its target antigens by IIF and ELISA can increase the positive percentage of ANCA in renal diseases. This novel screening strategy is able to distinguish atypical ANCA(aANCA) from pANCA with ANA and therefore useful for differential diagnosis between vasculitis and autoimmune diseases.
Xu
Yue-Qing
YQ
Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Chen
Wei
W
Li
Zhen-Jiang
ZJ
Liu
Xue-Song
XS
Wang
Han-Min
HM
Zhao
Jing
J
D019268:Antibodies, Antineutrophil Cytoplasmic; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007674:Kidney Diseases; D053146:Myeloblastin; D009195:Peroxidase; D014657:Vasculitis
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase; D053146:Myeloblastin