D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients.
Individual variation in drug response is considered to have multiple origins arising from interactions among susceptible genes and environmental factors. A total of 726 hypertensive patients who took benazepril 10 mg once a day for 15 days and their families from Huoqiu county of Anhui Province, China, were used to study the association between D919G polymorphism of methionine synthase (MTR) gene and the antihypertensive effect of this angiotensin-converting enzyme inhibitor. Compared to the 919D allele, both population-based ( P=0.010) and family-based association tests (additive model P=0.018, dominant model P=0.025) demonstrated that the 919G allele was associated with a significantly less diastolic blood pressure reduction. No significant association was found between the extent of systolic blood pressure reduction and benazepril therapy. Our finding suggests that the D919G polymorphism of the MTR gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril therapy in hypertensive patients of Anhui Province, China.
Zhang
Yan
Y
Department of Cardiology, Peking University First Hospital, Beijing, 100034, China.|Program for Population Genetics, Harvard School of Public Health, 665 Huntington Ave., FXB-101, Boston, MA, 02115, USA.
Zhang
Minmin
M
School of Life Science, University of Science and Technology in China, Hefei, China.
Niu
Tianhua
T
Program for Population Genetics, Harvard School of Public Health, 665 Huntington Ave., FXB-101, Boston, MA, 02115, USA.|Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215, USA.
Xu
Xin
X
Program for Population Genetics, Harvard School of Public Health, 665 Huntington Ave., FXB-101, Boston, MA, 02115, USA.
Zhu
Guoying
G
Department of Cardiology, Peking University First Hospital, Beijing, 100034, China.
Huo
Yong
Y
Department of Cardiology, Peking University First Hospital, Beijing, 100034, China.
Chen
Changzhong
C
Program for Population Genetics, Harvard School of Public Health, 665 Huntington Ave., FXB-101, Boston, MA, 02115, USA.
Wang
Xiaobin
X
The Mary Ann and J. Milburn Smith Child Health Program, Children's Memorial Hospital and Children's Memorial Institute for Education and Research (CMIER), Chicago, IL, 60614, USA.
Xing
Houxun
H
Institute of Biomedicine, Anhui Medical University, Hefei, China.
Peng
Shaojie
S
Institute of Biomedicine, Anhui Medical University, Hefei, China.
Huang
Aiqun
A
School of Life Science, University of Science and Technology in China, Hefei, China.
Hong
Xiumei
X
School of Life Science, University of Science and Technology in China, Hefei, China.
Xu
Xiping
X
Program for Population Genetics, Harvard School of Public Health, 665 Huntington Ave., FXB-101, Boston, MA, 02115, USA. xu@hsph.harvard.edu.|School of Life Science, University of Science and Technology in China, Hefei, China. xu@hsph.harvard.edu.|Institute of Biomedicine, Anhui Medical University, Hefei, China. xu@hsph.harvard.edu.
D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics*; D000328:Adult; D000368:Aged; D000483:Alleles; D000959:Antihypertensive Agents / Q000494:pharmacology; D001552:Benzazepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002681:China; D004777:Environment; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D011312:Pressure
D000959:Antihypertensive Agents; D001552:Benzazepines; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; C044946:benazepril