[Studies on design, synthesis and biodegradation of carrier for colon-site specific, drug delivery system].
OBJECTIVE
To design and synthesize a novel vector for colon-site specific drug delivery system and investigate the relationship between the biodegradation properties and composition of materials in the simulated colon fluid.


METHODS
The azocopolymer P (HEMA-MMA-MAA) was synthesized using 2-hydroxyethylmethacrylate (HEMA), methyl methacrylate (MMA) and methacrylic acid (MAA) as comonmer, azobisisobutyronitrilel (AIBN) as initiator, cross-linked with divinylazobezene (DVAB). The chemical structure of the synthesized series of azocopolymer is examined by UV, FTIR spectroscopy and nuclear magnetic resonance data. Their swelling behavior is evaluated by the swelling equilibrium parameter Q, the biodegradation tests of the materials were carried out at physiologically relevant buffer designed to mimic the colon environment. The biodegradation properties were assessed using the differential scanning calorimeters (DSC) and gel permeation chromatography (GPC) and the morphology on the surface of materials before and after degradation was observed by scanning electron microscopy (SEM).


RESULTS
The swelling equilibrium parameter Q increased with increasing the contents of HEMA and MAA in the materials. The degradation behavior was relevant to the ratio of three components in the copolymers.


CONCLUSIONS
This materials may become a good carrier for the colon-site specific drug delivery system if the contents of commoners HEMA, MMA and MAA are adjusted reasonably.
Chen
Jian-hai
JH
Department of Pharmaceutical Science, Nanfang Hospital, First Medical University of PIA, Guangzhou 510S15, China. jhchen@fimmu.com
Chen
Qing-yuan
QY
Sheng
Jia-rui
JR
Luo
Qi-zhi
QZ
D001391:Azo Compounds / Q000008:administration & dosage* / Q000378:metabolism; D001673:Biodegradation, Environmental; D003106:Colon / Q000378:metabolism*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000378:metabolism; D016503:Drug Delivery Systems; D005243:Feces / Q000382:microbiology; D006801:Humans; D008689:Methacrylates; D020366:Methylmethacrylate; D011108:Polymers / Q000008:administration & dosage / Q000378:metabolism; D013678:Technology, Pharmaceutical / Q000379:methods
D001391:Azo Compounds; D004337:Drug Carriers; D008689:Methacrylates; D011108:Polymers; D020366:Methylmethacrylate; C008384:methacrylic acid; C005044:hydroxyethyl methacrylate