Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.
In this study the chemical modification of paroxetine was employed to determine which structural differences between the paroxetine-like and femoxetine-like selective serotonin reuptake inhibitors is responsible for the differential potency of these agents in the inhibition of Staphylococcus aureus multidrug efflux pump systems.
Wei
Peng
P
Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, USA.
Kaatz
Glenn W
GW
Kerns
Robert J
RJ
D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D017374:Paroxetine / Q000737:chemistry* / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D010880:Piperidines; D017374:Paroxetine; C010655:femoxetine