title: A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity.
abstract: Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.
authors.affiliation: Equipe INSERM Avenir, Plasticité synaptique: Maturation & Addiction, Institut Magendie des Neurosciences, Rue Camille Saint Saëns, 33077 Bordeaux, France.
authors.forename: Susana
authors.initials: S
authors.lastname: Mato
authors.forename: Vivien
authors.initials: V
authors.lastname: Chevaleyre
authors.forename: David
authors.initials: D
authors.lastname: Robbe
authors.forename: Angel
authors.initials: A
authors.lastname: Pazos
authors.forename: Pablo E
authors.initials: PE
authors.lastname: Castillo
authors.forename: Olivier J
authors.initials: OJ
authors.lastname: Manzoni
mesh_terms: D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000037:antagonists & inhibitors* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000008:administration & dosage*; D063388:Endocannabinoids; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D051379:Mice; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects* / Q000502:physiology
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D013759:Dronabinol