title: Potential hypotensive agents: synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds.
abstract: The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2-b]- and naphth[2,1-b]-oxepin-5-ones (4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80 mm/Hg for >100' at a dose of 5mg/kg iv in anaesthetized cats.
authors.affiliation: Department of Chemistry, University of Lucknow, Lucknow-226007, India. vishnutandon@rediffmail.com
authors.forename: Vishnu K
authors.initials: VK
authors.lastname: Tandon
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
authors.forename: Anoop K
authors.initials: AK
authors.lastname: Awasthi
authors.forename: Hari O
authors.initials: HO
authors.lastname: Saxena
authors.forename: Gajendra K
authors.initials: GK
authors.lastname: Goswamy
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002415:Cats; D010082:Oxepins / Q000138:chemical synthesis* / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D010082:Oxepins; D010091:Oximes