[Renal xenotransplantation from hDAF pig to baboon. Experience and review].
The renal xenotransplant could be the solution on the demand of organs for transplantation. We present here our experience and review the actual status of the xenotransplant.


METHODS
We have done 20 xenotransplants from transgenic pig h DAF to baboons, with four protocols of immunosuppression. All the hosts were treated with GAS 914. Group A: Cyclophosphamide, Cyclosporine, Mycophenolate, and Steroids (n = 10). Group B: Cyclophosphamide, Cyclosporine, FTY 720, and Steroids (n = 3). Group C: Basiliximab, Cyclosporine, Mycophenolate, and Steroids (n = 3). Group D: Basiliximab, FTY 720, Everolymus, and Steroids (n = 4).


RESULTS
The duration of the xenografts ranged between 1 and 31 days. The function of the xenografts in relation to the type of immunosuppression were not significantly different: A) 7 days, B) 8 days, C) 8 days, and D) 9 days.


CONCLUSIONS
1. The cold ischemic time of the graft, has influence in the initial function of the kidneys but not in the evolution and duration of the graft. 2. The hyperacute rejection has been overcome with the utilization of transgenic pigs. The graft failure was due to acute humoral rejection that was not aborted by the actual inmunosupressors. 3. It is necessary to develop new immunosuppression protocols, through new knowledge of their pharmacology and the physiology of the xenografts, and at the same time it is important to avoid the potential risk of transmission of animal infections.
González Martín
M
M
Servicio de Urología, Hospital Universitario Juan Canalejo, Fundación Barrié de la Maza, La Coruña.
García Buitrón
J
J
Alonso Hernández
A
A
Centeno Cortés
A
A
López Peláez
E
E
Vázquez Martul
E
E
Mosquera Reboredo
J
J
Requejo Isidro
I
I
Máñez Mendiluce
R
R
D000818:Animals; D030801:Animals, Genetically Modified; D003165:Complement System Proteins / Q000276:immunology; D006085:Graft Survival; D016030:Kidney Transplantation / Q000276:immunology / Q000379:methods* / Q000473:pathology; D009336:Necrosis; D010215:Papio; D013552:Swine; D014183:Transplantation, Heterologous
D003165:Complement System Proteins