[Apoptosis and hibernation of cardiomyocytes of periscar zone as factor of chronic cardiac aneurysm progression].
Tissue specimen from chronic aneurysms and adjacent myocardium obtained at aneurysmectomy and coronary bypass surgery from 46 patients were subjected to morphological study. Immunohistochemical methods and electronic microscopy were applied for detection of apoptosis and hibernation of cardiomyocytes in 11 cases and histochemical determination of activity of energetic enzymes succinate and lactate dehydrogenase was used in 5 cases. Cardiomyocytes from peri and intra scar layers of myocardium were found to be in a state of hibernation while some of them were in a state of apoptosis. Extent of apoptosis was different in aneurysms on different stages of organization. Number of altered cardiomyocytes was the greatest in immature aneurysms. Basing on these findings apoptosis of hibernating cardiomyocytes was suggested to be one of factors of expansion of sclerotic zone and aneurysm formation.
Branishte
T A
TA
Cardiology Research Complex; ul. Tretiya Cherepkovskaya, 15a, 121552 Moscow, Russia.
Sokolova
R I
RI
Zhdanov
V S
VS
Cherpachenko
N M
NM
Khodareva
E N
EN
Tsyplenkova
V G
VG
Skridlevskaia
E A
EA
Naumov
V G
VG
Akchurin
R S
RS
D017209:Apoptosis; D006322:Heart Aneurysm; D006605:Hibernation; D006801:Humans; D009206:Myocardium; D032383:Myocytes, Cardiac