title: Amniotic fluid embolism with haemostasis complications: primary fibrinogenolysis or disseminated intravascular coagulation?
abstract: Amniotic fluid embolism (AFE) is characterized by the passage of amniotic fluid (AF) into the maternal circulation during or just after childbirth. AFE is a rare disorder occurring in 1/8,000 to 1/80,000 deliveries but with a maternal morbidity ranging from 26% in a recent report to 86% in earlier ones. In patients who survive, AFE may affect coagulation resulting in severe bleeding. While disseminated intravascular coagulation (DIC) is usually seen in such cases, we reported a case of AFE in which the hemostatic abnormalities were compatible with primary fibrinogenolysis rather than with DIC.
authors.affiliation: Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Montpellier, France. c-biron@chu-montpellier.fr
authors.forename: C
authors.initials: C
authors.lastname: Biron-Andréani
authors.forename: E
authors.initials: E
authors.lastname: Morau
authors.forename: J-F
authors.initials: JF
authors.lastname: Schved
authors.forename: B
authors.initials: B
authors.lastname: Hédon
authors.forename: H
authors.initials: H
authors.lastname: Dechaud
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000209:etiology; D016913:Blood Component Transfusion; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology; D004619:Embolism, Amniotic Fluid / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005342:Fibrinolysis; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006487:Hemostasis; D006801:Humans; D011247:Pregnancy; D016896:Treatment Outcome