Cell adhesion and angiogenesis.
Cell-adhesion mechanisms play a fundamental role during angiogenesis. This article summarizes the role of various cell-adhesive events in blood vessel formation, including general aspects of cell-matrix and cell-cell interactions. In particular, the authors discuss the role of integrin alphavbeta3 in vascular cell survival, proliferation and invasion during the complex process of angiogenesis.
Strömblad
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Dept of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. staffans@scripps.edu
Cheresh
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DA