title: What are the limits to the size of effective dynamic combinatorial libraries?
abstract: Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10(6) compounds. [structure: see text]
authors.affiliation: Cambridge University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, U.K.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Corbett
authors.forename: Sijbren
authors.initials: S
authors.lastname: Otto
authors.forename: Jeremy K M
authors.initials: JK
authors.lastname: Sanders