title: [Species specificity of the isoenzyme profile of lactate dehydrogenase in organs of rodents of various ecogenesis].
abstract: Separation of isoenzymes of lactate dehydrogenase (LDH, EC. 1.1.1.27) in extracts of heart, kidney, liver, spleen, lungs of nutrias, chinchillas by agar gel electrophoresis reveals a species specificity in ratio of electrophoretic fractions of the enzyme. The isoenzymes of LDH were seem to play an important role in adaptation of fur animals to environmental conditions. It has been shown that in semiaquatic mammals--nutrias, the relative content of the A-subunits in the isoenzymatic spectrum of LDH in organs was increased as compared with terrestrial animals--chinchillas, whereas relative content of B-subunits in these organs of chinchillas was very high. This is an example of subtle biochemical specialisation of function at molecular level to environmental conditions.
authors.affiliation: Institute of Biology, Karelian Scientific Centre, Russian Acad. Sci., 185610, Petrozavodsk, Pushinskaya St. 11, Karelia, Russia.
authors.forename: L K
authors.initials: LK
authors.lastname: Kozhevnikova
authors.forename: N N
authors.initials: NN
authors.lastname: Tiutiunnik
authors.forename: A R
authors.initials: AR
authors.lastname: Unzhakov
authors.forename: Kh I
authors.initials: KhI
authors.lastname: Meldo
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004587:Electrophoresis, Agar Gel; D004777:Environment; D007527:Isoenzymes / Q000737:chemistry / Q000302:isolation & purification; D045022:Lactate Dehydrogenases / Q000737:chemistry / Q000302:isolation & purification*; D009928:Organ Specificity; D021122:Protein Subunits; D012377:Rodentia / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D007527:Isoenzymes; D021122:Protein Subunits; D045022:Lactate Dehydrogenases