title: [Varicosis of the lower extremities as a consequence of connective tissue dysplasia].
abstract: An analysis was made of two groups of patients presenting with varicosis. The first group comprised 82 patients aged 15 to 30 years without risk factors. The second group accrued 85 patients with traditional risk factors: pregnancy and birth, overweight, considerable dynamic and physical loading, age from 30 to 50 years, and intake of hormonal contraceptives. It has been established that the key role in the development of varicosis is played by connective tissue dysplasia (CTD), the intensity of which predetermines the origination of phlebopathy and varicosis as well as the rate of their progression. The most frequently occurring is the mechanism of the development of phlebopathy as structural and functional defectiveness of all venous vessels of the extremity, leading to the rise of the deposited blood volume in the leg because of the high elasticity of venous walls. Secondly, CTD that initially impairs valve morphology, results in local varicosis under the effect of reflux hydrodynamic strokes at the weakened venous wall.
authors.forename: Iu T
authors.initials: IuT
authors.lastname: Tsukanov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Tsukanov
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000150:complications* / Q000473:pathology*; D011230:Precancerous Conditions / Q000150:complications* / Q000473:pathology*; D014648:Varicose Veins / Q000209:etiology* / Q000601:surgery