title: Pathophysiology of acute lung injury in combined burn and smoke inhalation injury.
abstract: In the U.S.A., more than 1 million burn injuries occur every year. Although the survival from burn injury has increased in recent years with the development of effective fluid resuscitation management and early surgical excision of burned tissue, the mortality of burn injury is still high. In these fire victims, progressive pulmonary failure and cardiovascular dysfunction are important determinants of morbidity and mortality. The morbidity and mortality increases when burn injury is associated with smoke inhalation. In the present review, we will describe the pathophysiological aspects of acute lung injury induced by combined burn and smoke inhalation and examine various therapeutic approaches.
authors.affiliation: Department of Anesthesiology, University of Texas Medical Branch, 610 Texas Ave, Galveston, TX 77555, USA.
authors.forename: Perenlei
authors.initials: P
authors.lastname: Enkhbaatar
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Traber
mesh_terms: D000208:Acute Disease; D000328:Adult; D000402:Airway Obstruction / Q000209:etiology / Q000503:physiopathology; D002059:Burns, Inhalation / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000503:physiopathology; D055370:Lung Injury; D009569:Nitric Oxide / Q000506:poisoning; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology; D015208:Smoke Inhalation Injury / Q000150:complications / Q000503:physiopathology
chemical_list: D009569:Nitric Oxide; D011065:Poly(ADP-ribose) Polymerases