title: Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis.
abstract: The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49-85 years with knee OA were studied. Anterior-posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups: 37 patients exhibiting generalized osteoarthritis (GOA) and 34 non-GOA patients, according to the grading of their hand radiograph. C-reactive protein (CRP), urinary pyridinoline, YKL-40, plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of arthritis. The radiographic grading with the Kellgren-Lawrence scale revealed a significant relationship to the joint space width (P = 0.003): the joint space width decreased with increasing Kellgren-Lawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation (P = 0.039). Pyridinoline (P = 0.034) and TIMP-1 (P = 0.017) also exhibited a significant relationship to the Kellgren-Lawrence grade. In GOA evaluations, the joint space width did not differ between GOA and non-GOA patients. CRP, pyridinoline, YKL-40 and MMP-3 levels were significantly greater in GOA patients than in non-GOA patients. CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type of radiographic grading examined in the present study.
authors.affiliation: Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan. taka1m@hama-med.ac.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Naito
authors.forename: Masashi
authors.initials: M
authors.lastname: Abe
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Sawada
authors.forename: Akira
authors.initials: A
authors.lastname: Nagano
mesh_terms: D054392:Adipokines; D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D002097:C-Reactive Protein / Q000378:metabolism; D000071451:Chitinase-3-Like Protein 1; D018450:Disease Progression; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006225:Hand / Q000473:pathology; D006801:Humans; D037102:Lectins; D019278:Matrix Metalloproteinase 3 / Q000097:blood; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000000981:diagnostic imaging / Q000652:urine; D020370:Osteoarthritis, Knee / Q000097:blood / Q000000981:diagnostic imaging* / Q000652:urine; D017698:Postmenopause / Q000097:blood / Q000378:metabolism / Q000652:urine; D011859:Radiography; D013128:Spinal Osteophytosis / Q000097:blood / Q000000981:diagnostic imaging / Q000652:urine; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
chemical_list: D054392:Adipokines; D000596:Amino Acids; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins; D019715:Tissue Inhibitor of Metalloproteinase-1; C015484:pyridinoline; D002097:C-Reactive Protein; D019278:Matrix Metalloproteinase 3; D020780:Matrix Metalloproteinase 9