title: Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women.
abstract: OBJECTIVE
  To further investigate the role of prior medical conditions and medication use in the etiology of non-Hodgkin lymphoma (NHL), we analyzed the data from a population-based case-control study of NHL in Connecticut women.
  
  
  METHODS
  A total of 601 histologically confirmed incident cases of NHL and 717 population-based controls were included in this study. In-person interviews were administered using standardized, structured questionnaires to collect information on medical conditions and medication use.
  
  
  RESULTS
  An increased risk was found among women who had a history of autoimmune disorders (such as rheumatoid arthritis, lupus erythematosus, Sjogren's syndrome, and multiple sclerosis), anemia, eczema, or psoriasis. An increased risk was also observed among women who had used steroidal anti-inflammatory drugs and tranquilizers. A reduced risk was found for women who had scarlet fever or who had used estrogen replacement therapy, aspirin, medications for non-insulin dependent diabetes, HMG-CoA reductase inhibitors, or beta-adrenergic blocking agents. Risk associated with past medical history appeared to vary based on NHL subtypes, but the results were based on small number of exposed subjects.
  
  
  CONCLUSIONS
  A relationship between certain prior medical conditions and medication use and risk of NHL was observed in this study. Further studies are warranted to confirm our findings.
authors.affiliation: Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA.
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holford
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Shelia Hoar
authors.initials: SH
authors.lastname: Zahm
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
authors.forename: Lindsay McOmber
authors.initials: LM
authors.lastname: Morton
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Kaiyong
authors.initials: K
authors.lastname: Zou
authors.forename: Stuart
authors.initials: S
authors.lastname: Flynn
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tallini
authors.forename: Patricia H
authors.initials: PH
authors.lastname: Owens
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000740:Anemia / Q000150:complications; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001327:Autoimmune Diseases / Q000150:complications; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D004485:Eczema / Q000150:complications; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D008487:Medical History Taking; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D014149:Tranquilizing Agents / Q000009:adverse effects; D016387:Women's Health
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D014149:Tranquilizing Agents