PEG-supported synthesis of pyrazole oligoamides with peptide beta-sheet affinity.
Pyrazole amino acid oligoamides were prepared on polyethylene glycol starting from nitro pyrazole carboxylic acids or protected pyrazole amino acids. The polymer support facilitates product isolation during synthesis and makes the target oligoamides soluble in chloroform and water. This allows the determination of their binding properties towards peptides. Moderate affinity, which increases with the number of pyrazole units, is observed in chloroform and water.
Cernovská
Katerina
K
Institut für Organische Chemie, Universität Regensburg, Germany.
Kemter
Miriam
M
Gallmeier
Hans-Christoph
HC
Rzepecki
Petra
P
Schrader
Thomas
T
König
Burkhard
B