title: Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma.
abstract: We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.
authors.affiliation: Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Hori
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kami
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Kim
authors.forename: Atsushi
authors.initials: A
authors.lastname: Makimoto
authors.forename: Ryuji
authors.initials: R
authors.lastname: Tanosaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Takaue
mesh_terms: D000208:Acute Disease; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000473:pathology*; D020350:Graft vs Tumor Effect / Q000276:immunology*; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D011859:Radiography; D033581:Stem Cell Transplantation