Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
Antibodies specific for the beta(1)-adrenergic receptor are found in patients with chronic heart failure of various etiologies. From work presented in this issue of the JCI, we can now infer that these antibodies actually contribute to the pathogenesis of chronic heart failure. This commentary discusses mechanisms by which these antibodies may engender cardiomyopathy.
Freedman
Neil J
NJ
Department of Medicine (Cardiology), Duke University Medical Center, Durham, North Carolina 27710, USA. .
Lefkowitz
Robert J
RJ
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology*; D006801:Humans; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism; D018342:Receptors, Adrenergic, beta-1 / Q000276:immunology*
D000319:Adrenergic beta-Antagonists; D001323:Autoantibodies; D018342:Receptors, Adrenergic, beta-1