title: Relationship between the degree of intracellular magnesium deficiency and the frequency of chest pain in women with variant angina.
abstract: OBJECTIVE
  This study sought to clarify the relationship between the degree of intracellular magnesium deficiency and the frequency of anginal attacks in women with variant angina.
  
  
  METHODS
  We evaluated the intracellular and extracellular magnesium status of twelve women with variant angina: group A (> or = 4 attacks/week, n = 5) and group B (< 4 attacks/week, n = 7). Magnesium levels were determined in serum, urine, and erythrocytes, and the 24-h magnesium retention rate was calculated by magnesium loading test.
  
  
  RESULTS
  Group A showed a higher 24-h magnesium retention rate (58.2 +/- 9.1% vs. 31.3 +/- 4.4%; p < 0.01) and a lower intracellular concentration of magnesium in erythrocytes than group B (3.1 +/- 1.1 vs. 5.0 +/- 0.8 fg/cell; p < 0.05), demonstrating the presence of magnesium deficiency in group A. The 24-h magnesium retention rate and intracellular concentrations of magnesium in erythrocytes correlated well with the activity of variant angina (r = 0.61, p < 0.01; and r = -0.74, p < 0.01, respectively) for these patients.
  
  
  CONCLUSIONS
  This study demonstrates that the degree of intracellular magnesium deficiency in women with variant angina is closely related to the frequency of chest pain.
authors.affiliation: First Department of Internal Medicine, Fukui Medical University, Fukui, Japan. ghangyuan@hotmail.com
authors.forename: Hangyuan
authors.initials: H
authors.lastname: Guo
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cheng
authors.forename: Jong-Dae
authors.initials: JD
authors.lastname: Lee
authors.forename: Takanori
authors.initials: T
authors.lastname: Ueda
authors.forename: Jiang
authors.initials: J
authors.lastname: Shan
authors.forename: Jian'an
authors.initials: J
authors.lastname: Wang
mesh_terms: D000368:Aged; D000788:Angina Pectoris, Variant / Q000209:etiology* / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D002637:Chest Pain / Q000209:etiology* / Q000378:metabolism*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000150:complications* / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D008274:Magnesium