Cerebellar and hippocampal activation during eyeblink conditioning depends on the experimental paradigm: a MEG study.
The cerebellum and the hippocampus are key structures for the acquisition of conditioned eyeblink responses. Whereas the cerebellum seems to be crucial for all types of eyeblink conditioning, the hippocampus appears to be involved only in complex types of learning. We conducted a differential conditioning study to explore the suitability of the design for magnetencephalography (MEG). In addition, we compared cerebellar and hippocampal activation during differential delay and trace conditioning. Comparable conditioning effects were seen in both conditions, but a greater resistance to extinction for trace conditioning. Brain activation differed between paradigms: delay conditioning provoked activation only in the cerebellum and trace conditioning only in the hippocampus. The results reflect differential brain activation patterns during the two types of eyeblink conditioning.
Kirsch
Peter
P
Department of Clinical & Physiological Psychology, University of Giessen, Germany. peter.kirsch@psychol.uni-giessen.de
Achenbach
Caroline
C
Kirsch
Martina
M
Heinzmann
Matthias
M
Schienle
Anne
A
Vaitl
Dieter
D
D000328:Adult; D001767:Blinking / Q000502:physiology*; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male