title: Basilar artery to bilateral posterior cerebral artery 'Y stenting' for endovascular reconstruction of wide-necked basilar apex aneurysms: report of three cases.
abstract: Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA stents bilaterally in a 'Y' configuration to reconstruct the BA apex for effective coil embolization. Three patients (aged 70, 65 and 37 years) with wide-necked basilar artery aneurysms presented for endovascular treatment. All aneurysms had necks that involved the bilateral P1 segments. Each patient was deemed an appropriate candidate for endovascular reconstruction. Patients were pretreated with clopidogrel (75 mg) and aspirin (325 mg) each day for 3 days prior to the procedure. Following induction of general anesthesia, access to the right femoral artery was obtained by placement of a 6F sheath. Intravenous heparin was administered to achieve an activated coagulation time (ACT) of approximately 300 seconds. A 6F guide catheter was placed within the left vertebral artery (VA) in two patients, the right VA in a third. Utilizing over-the-wire (OTW) technique, a microcatheter was advanced into the left P2-P3 junction of the PCA. A 300-cm 0.014-inch microwire was passed through the microcatheter into the distal PCA and the microcatheter was removed. In each case, two neuroform stents were prepared (SMART Therapeutics Inc., San Leandro, CA) and advanced OTW into the PCA with the most acute angle relative to the BA. The initial stent placed was 20 mm in length and was deployed from the P1 segment into the BA. The microwire was pulled retrograde into the BA apex, then advanced though the stent struts and into the right PCA. A second stent, 15 mm in length, was advanced OTW through the struts of the previously placed stent. It was then deployed from the P1 into the BA where it overlapped the first stent, resulting in a stent-in-stent 'Y' configuration at the BA apex. A microcatheter was advanced OTW into the BA apex aneurysm and coil embolization proceeded in the usual fashion. Following the procedure, each patient was maintained in the neurosurgical intensive care unit (NICU). All remained neurologically intact. The two elderly patients were discharged to home the morning following the procedure. The third patient suffered an upper GI bleed and was treated an additional 3 days in hospital. Oral clopidogrel (75 mg by mouth) and aspirin (325 mg by mouth) were continued daily for 4 weeks. The 'Y' stent configuration for reconstruction of the BA apex is a safe effective technique in patients with wide-necked BA aneurysms.
authors.affiliation: Department of Neurosurgery, Harper University Hospital and the Detroit Medical Center, Detroit, Michigan USA. eperez@neurosurgery.wayne.edu
authors.forename: Eimir
authors.initials: E
authors.lastname: Perez-Arjona
authors.forename: Richard D
authors.initials: RD
authors.lastname: Fessler
mesh_terms: D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use; D002533:Cerebral Angiography / Q000379:methods; D000077144:Clopidogrel; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D020769:Posterior Cerebral Artery / Q000294:innervation / Q000473:pathology; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin