[Detection of serum coxsackievirus B-specific antibody and nucleic acid in aged patients with cardiopathy].
OBJECTIVE
To understand the status of coxsackievirus B (CVB) infection in senior subjects and explore the association of the infection with cardiovascular diseases.


METHODS
By means of ELISA and RT-PCR, CVB IgG antibody and nucleic acid were detected in 172 patients with cardiopathy and 58 control subjects.


RESULTS
The positivity rate of CVB IgG antibody was 43.61% (75/172) in the patient group and 15.52% (9/58) in the control group, showing obvious difference between the two groups. CVB RNA tests revealed a CVB RNA-positivity rate of 20.93% (36/172) in the former group and 3.45% (2/58) in the latter, with also a significant difference (P<0.01).


CONCLUSIONS
CVB infection is prevalent in aged patients with heart disease, which should be given due attention to.
Sun
Yun-yun
YY
Guangdong Cardiovascular Institute of Guangdong Province, Guangzhou 510100, China.
Jiang
Wen-lin
WL
Luo
Xian-ling
XL
D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D029822:Enterovirus B, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006331:Heart Diseases / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D012367:RNA, Viral