Effect of multielement intravascular ultrasound on the anticoagulant potency of enoxaparin.
Two patients, treated with enoxaparin and eptifibatide, developed significant guide catheter-associated thrombus while undergoing intravascular ultrasound (IVUS). Using an ex vivo assay, we found that activation of a multielement IVUS catheter resulted in a decrease in anti-Xa activity and a decrease in clot formation time. This effect occurred rapidly and repeatedly after activation of the IVUS catheter.
Stouffer
George A
GA
Division of Cardiology, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599-7075, USA. rstouff@med.unc.edu
Pathak
Alok
A
Whinna
Herbert C
HC
Ohman
E Magnus
EM
D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology* / Q000627:therapeutic use; D017984:Enoxaparin / Q000494:pharmacology* / Q000627:therapeutic use; D000077542:Eptifibatide; D015951:Factor Xa / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D013927:Thrombosis / Q000209:etiology*; D018084:Ultrasonography, Interventional / Q000009:adverse effects* / Q000295:instrumentation; D014914:Whole Blood Coagulation Time
D000925:Anticoagulants; D017984:Enoxaparin; D010455:Peptides; D015951:Factor Xa; D000077542:Eptifibatide