On the stability of furanopyrimidin-2-one bases in oligonucleotides.
The fluoresceinated furanopyrimidin-2-one nucleobase incorporated into an oligonucleotide undergoes unexpectedly facile hydrolytic ring-opening in aqueous buffer at slightly elevated temperatures.
Jiao
Guan-Sheng
GS
Department of Chemistry, PO Box 30012, Texas A & M University, College Station, TX 77842-3012, USA.
Burgess
Kevin
K
D001483:Base Sequence; D005663:Furans / Q000737:chemistry; D006358:Hot Temperature; D008969:Molecular Sequence Data; D009005:Monosaccharides / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*
D005663:Furans; D009005:Monosaccharides; D009841:Oligonucleotides; D011743:Pyrimidines; C499499:furanopyrimidin-2-one