title: Four pedigrees of the cation-leaky hereditary stomatocytosis class presenting with pseudohyperkalaemia. Novel profile of temperature dependence of Na+-K+ leak in a xerocytic form.
abstract: We report four pedigrees of the group of Na(+)-K(+)-leaky red cell disorders of the 'hereditary stomatocytosis' class. Each showed pseudohyperkalaemia because of temperature-dependent loss of K(+) from red cells on storage of whole blood at room temperature. All pedigrees showed an abnormality in the temperature dependence of the 'passive leak' of the membrane to K(+). Two pedigrees, both of which showed a compensated haemolytic state with dehydrated red cells and target cells on the blood film, showed a novel pattern, in which the profile was flat between 37 degrees C and about 32 degrees C then dropped as the temperature was reduced to zero. The third showed the 'shallow slope' profile, with stomatocytes on the blood film and very markedly abnormal intracellular Na(+) and K(+) levels. Minimal haemolysis was present. The fourth pedigree, of Asian origin, showed the shoulder pattern (minimum at 32 degrees C, maximum at 12 degrees C) with essentially normal haematology. Both of these latter two forms have previously been seen in other pedigrees. The first variant represents a novel kind of temperature dependence of the passive leak found in these pedigrees presenting with pseudohyperkalaemia.
authors.affiliation: Department of Medicine, University College London, Rayne Institute, London, UK.
authors.forename: D M
authors.initials: DM
authors.lastname: Gore
authors.forename: Mark
authors.initials: M
authors.lastname: Layton
authors.forename: A K
authors.initials: AK
authors.lastname: Sinha
authors.forename: P J
authors.initials: PJ
authors.lastname: Williamson
authors.forename: Bijay
authors.initials: B
authors.lastname: Vaidya
authors.forename: V
authors.initials: V
authors.lastname: Connolly
authors.forename: P
authors.initials: P
authors.lastname: Mannix
authors.forename: M C
authors.initials: MC
authors.lastname: Chetty
authors.forename: Anna
authors.initials: A
authors.lastname: Nicolaou
authors.forename: G W
authors.initials: GW
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000097:blood*; D002412:Cations / Q000378:metabolism; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000097:blood; D007231:Infant, Newborn; D017136:Ion Transport; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013696:Temperature
chemical_list: D002412:Cations; D012964:Sodium; D011188:Potassium