Decreased total nitric oxide production in patients with duchenne muscular dystrophy.
Plasma nitric oxide (NO) levels in Duchenne muscular dystrophy (DMD) patients were significantly lower than those observed in both healthy controls and in patients with other neuromuscular disorders. The correlation between NO level and ejection fraction was significant (r = -0.384, p = 0.0391) in the DMD group. Disruption of NO systems may contribute to the development of muscular dystrophy and have implications for therapeutic strategies.
Kasai
Takefumi
T
Department of Neurology and Geriatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. tkasai@m.kufm.kagoshima-u.ac.jp
Abeyama
Kazuhiro
K
Hashiguchi
Teruto
T
Fukunaga
Hidetoshi
H
Osame
Mitsuhiro
M
Maruyama
Ikuro
I
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D015536:Down-Regulation; D004452:Echocardiography; D006801:Humans; D008875:Middle Aged; D020388:Muscular Dystrophy, Duchenne / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D010084:Oxidation-Reduction; D013318:Stroke Volume
D009569:Nitric Oxide