What kind of message does IL-12/IL-23 bring to macrophages and dendritic cells?
The present review illustrates the current knowledge on the autocrine effect of IL-12, and the putative contribution of IL-23, on macrophages and dendritic cells, focusing on cell activation and microbicidal activity. Here, we present convincing evidence that IL-12 is not only a connective element between accessory cells and lymphocytes, but it is also a key molecule for programming the macrophage and dendritic cell functions.
Bastos
Karina R B
KR
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Sao Paulo, Brazil. krbastos@usp.br
Marinho
Claudio R F
CR
Barboza
Renato
R
Russo
Momtchilo
M
Alvarez
José M
JM
D'Império Lima
Maria Regina
MR
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology / Q000502:physiology*; D053759:Interleukin-23; D053760:Interleukin-23 Subunit p19; D007378:Interleukins / Q000276:immunology / Q000502:physiology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D015398:Signal Transduction
C508840:IL23A protein, human; D053759:Interleukin-23; D053760:Interleukin-23 Subunit p19; D007378:Interleukins; D018664:Interleukin-12