title: Alfa-epoietin and anaemia in gynaecological cancer.
abstract: The incidence and severity of anaemia in gynaecological cancer patients depends on several factors including age, histology and tumor stage, site of neoplasm and treatment. At present, two principal opinions are available for the management of chronic anaemia in cancer patients: blood transfusions and treatment with recombinant human Erythropoietin (rHuEPO). Clinical studies showed that rHuEPO can ameliorate chronic and chemotherapy-induced anaemia and reduce transfusions in patients with various malignant diseases. In this review we discuss the role of alfa-epoetin in the management of gynaecological and breast cancers.
authors.affiliation: Division of Medical Oncology, Regina Elena National Cancer Institute, via Elio Chianesi 53, 00144 Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Di Cocco
authors.forename: Nello
authors.initials: N
authors.lastname: Salesi
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fabi
authors.forename: Chiara
authors.initials: C
authors.lastname: Nardoni
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Ferretti
authors.forename: Giandominik
authors.initials: G
authors.lastname: Bossone
authors.forename: Mariangela
authors.initials: M
authors.lastname: Ciccarese
authors.forename: Antonella
authors.initials: A
authors.lastname: Savarese
authors.forename: Aldo
authors.initials: A
authors.lastname: Vecchione
authors.forename: Francesco
authors.initials: F
authors.lastname: Cognetti
mesh_terms: D000740:Anemia / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D001803:Blood Transfusion; D002986:Clinical Trials as Topic; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000532:radiotherapy; D006801:Humans; D011788:Quality of Life; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin