title: Vascular brachytherapy: a new approach to renal artery in-stent restenosis.
abstract: Renovascular hypertension is frequently the result of atherosclerosis and has been successfully treated with percutaneous angioplasty. Stenting of vessels has helped to significantly lower the rate of restenosis after angioplasty; however, neointimal hyperplasia frequently results in growth of tissue through the stent, causing in-stent restenosis. Similar problems are seen in coronary stenting, and vascular brachytherapy has been shown to effectively prevent repeat in-stent restenosis. While coronary and renal restenoses occur by a common physiologic mechanism, their anatomic differences have prevented widespread adaptation of vascular brachytherapy to renal in-stent restenoses. A number of recent reports have demonstrated efficacy of renal vascular brachytherapy, but thus far, no large-scale, randomized data is available. Herein is reviewed the subject of renal vascular brachytherapy and the studies that are presently used in its justification.
authors.affiliation: Department of Radiation Medicine, University of Kentucky College of Medicine, 800 Rose Street, Room C-1, Lexington, KY 40536-0293, USA. cdjahraus@msn.com
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Jahraus
authors.forename: Ali S
authors.initials: AS
authors.lastname: Meigooni
mesh_terms: D000800:Angioplasty, Balloon / Q000639:trends; D019917:Blood Vessel Prosthesis Implantation; D001918:Brachytherapy / Q000639:trends; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000628:therapy; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology / Q000628:therapy; D012078:Renal Artery Obstruction / Q000628:therapy; D015607:Stents