title: [Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B infection].
abstract: OBJECTIVE
  To explore the role of chemokine receptor CXCR3 in pathogenesis of chronic hepatitis B.
  
  
  METHODS
  The expression of CXCR3 on peripheral blood lymphocytes from chronic hepatitis B patients with various degrees of inflammation was detected, and the distributions of CXCR3 on CD4(+) and CD8(+) T lymphocytes were also evaluated by FACS.
  
  
  RESULTS
  As compared with healthy control, the percentages of CXCR3(+) lymphocytes, monocytes and CD8(+) T cells were increased significantly in chronic hepatitis B patients.
  
  
  CONCLUSIONS
  Above data suggest that chemokine receptor CXCR3 may play an important role in the recruitment of lymphocytes, especially CTLs recruited to inflammation sites.
authors.affiliation: Institute of Immunology, The First Affiliated Hospital, Zhejiang University, Hangzhou 310016, China.
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Shi
authors.forename: Li-Huang
authors.initials: LH
authors.lastname: Zhang
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Li
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000378:metabolism; D006801:Humans; D009000:Monocytes / Q000378:metabolism; D054367:Receptors, CXCR3 / Q000276:immunology; D019707:Receptors, Chemokine; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D054367:Receptors, CXCR3; D019707:Receptors, Chemokine