Pathogenic consequences of Neisseria gonorrhoeae pilin glycan variation.
A Neisseria gonorrhoeae (gonococcus, GC) pilin glycosylation gene, pgtA, can either possess or lack phase-variation ability. Many GC, particularly the disseminated strains, carry a phase-variable pgtA. However, other GC, predominantly the uncomplicated gonorrhea isolates, carry a pgtA lacking phase-variability. These and other results suggest GC pilin glycan's pathogenic involvement.
Ghosh
Salil K
SK
Department of Microbiology and Immunology, New York Medical College, Basic Science Building, RM 340, Valhalla, NY 10595, USA.
Zhao
Jie
J
Philogene
Mary C
MC
Alzaharani
Abdulrahaman
A
Rane
Supriya
S
Banerjee
Asesh
A
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D036781:Fimbriae Proteins / Q000737:chemistry* / Q000378:metabolism; D014644:Genetic Variation; D006031:Glycosylation; D006069:Gonorrhea / Q000382:microbiology / Q000473:pathology; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000235:genetics / Q000472:pathogenicity*; D011134:Polysaccharides / Q000737:chemistry*
D001426:Bacterial Proteins; D011134:Polysaccharides; D036781:Fimbriae Proteins