p75NTR is positively promiscuous: novel partners and new insights.
Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.
Barker
Philip A
PA
Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada. phil.barker@mcgill.ca
D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D016923:Cell Death / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins / Q000378:metabolism; D009185:Myelin Proteins / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009420:Nervous System / Q000254:growth & development / Q000378:metabolism*; D000070798:Nogo Proteins; D011485:Protein Binding / Q000502:physiology; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D000099183:Sortilin
D033942:Adaptor Proteins, Vesicular Transport; D008024:Ligands; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D000070798:Nogo Proteins; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor; D000099183:Sortilin; C000603199:RTN4 protein, human