title: Extreme secretion: protein translocation across the archael plasma membrane.
abstract: In all three domains of life, extracytoplasmic proteins must overcome the hurdle presented by hydrophobic, lipid-based membranes. While numerous aspects of the protein translocation process have been well studied in bacteria and eukarya, little is known about how proteins cross the membranes of archaea. Analysis to date suggests that archael protein translocation is a mosaic of bacterial, eukaryal, and archaeal features, as indeed is much of archaeal biology. Archaea encode homologues of selected elements of the bacterial and eukaryal translocation machines, yet lack other important components of these two systems. Other aspects of the archaeal translocation process appear specific to this domain, possibly related to the extreme environmental conditions in which archsea thrive. In the following, current understanding of archaeal protein translocation is reviewed, as is recent progress in reconstitution of the archaeal translocation process in vitro.
authors.affiliation: Department of Life Sciences, Ben Gurion University, P.O. Box 653, Beersheva 84105, Beersheva, Israel.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Ring
authors.forename: Jerry
authors.initials: J
authors.lastname: Eichler
mesh_terms: D001105:Archaea / Q000502:physiology*; D019843:Archaeal Proteins / Q000378:metabolism*; D001693:Biological Transport, Active; D002462:Cell Membrane / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*
chemical_list: D019843:Archaeal Proteins; D008565:Membrane Proteins; D021382:Protein Sorting Signals