ALIX-ing phospholipids with endosome biogenesis.
Endosomes, which comprise a diverse population of membrane vesicles and tubules, sort proteins and lipids to various cellular destinations. The organization and functions of these pleiomorphic cellular organelles have been extensively studied. Matsuo et al.1 now provide new exciting evidence on the role of lysobiphosphatidic acid (LBPA), a resident phospholipid of internal vesicles of the late endosome, in the control of membrane invagination and endosome biogenesis. In vivo, LBPA functions are controlled by the adaptor protein Alix and depend on pH gradients along the endosomal compartments.
Dikic
Ivan
I
Institute of Biochemistry II, Goethe University Medical School, 60590 Frankfurt, Germany. Ivan.Dikic@biochem2.de
D000818:Animals; D002135:Calcium-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology*; D018797:Cell Cycle Proteins; D002462:Cell Membrane / Q000378:metabolism; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008051:Lipid Bilayers; D050356:Lipid Metabolism; D008246:Lysophospholipids / Q000378:metabolism; D008954:Models, Biological; D050178:Monoglycerides; D010743:Phospholipids / Q000378:metabolism; D011485:Protein Binding
D002135:Calcium-Binding Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D008051:Lipid Bilayers; D008246:Lysophospholipids; D050178:Monoglycerides; C117020:PDCD6IP protein, human; D010743:Phospholipids; C012786:bis(monoacylglyceryl)phosphate