title: Rocky Mountain spotted fever at Koair Children's Hospital, 1990-2002.
abstract: The reported average annual incidence of Rocky Mountain spotted fever (RMSF) in Kentucky is less than 5 per million population, although seroprevalence studies suggest that exposure to Rickettsia riskettsii, the causative agent, is relatively common among children. The experience with RMSF at Kosair Children's Hospital over a 12-year period was reviewed. Fifteen cases were identified (5 boys and 10 girls). Illness onset ranged from April to October, and 4 patients resided in Jefferson County. The classic triad of fever, rash, and headache was present in only 60% of cases, and tick attachment was reported in only 40%. On average, 6 days elapsed from onset of symptoms to initiation of appropriate antibiotic therapy. One patient suffered splenic infarction and necrosis of the digits due to shock and disseminated intravascular coagulopathy, and 2 patients died. RMSF is a significant cause of pediatric morbidity and mortality in this region of Kentucky. Affected children may reside in relatively urban parts of the state. Initial clinical features may be nonspecific. This, as well as decreased awareness of disease and (unjustified) reluctance to use doxycycline may contribute to delays in initiating therapy.
authors.affiliation: Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Hayden
authors.forename: Gary S
authors.initials: GS
authors.lastname: Marshall
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007223:Infant; D007629:Kentucky / Q000453:epidemiology; D008297:Male; D012189:Retrospective Studies; D012284:Rickettsia rickettsii / Q000302:isolation & purification*; D012373:Rocky Mountain Spotted Fever / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D012621:Seasons
chemical_list: D000890:Anti-Infective Agents