title: Salmonella gene rma (ramA) and multiple-drug-resistant Salmonella enterica serovar typhimurium.
abstract: MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common MDR mechanism in Salmonella.
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands. j.t.van_dissel@lumc.nl
authors.forename: Tahar
authors.initials: T
authors.lastname: van der Straaten
authors.forename: Riny
authors.initials: R
authors.lastname: Janssen
authors.forename: Dik J
authors.initials: DJ
authors.lastname: Mevius
authors.forename: Jaap T
authors.initials: JT
authors.lastname: van Dissel
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D009154:Mutation / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D010957:Plasmids / Q000235:genetics; D019779:Salmonella enterica / Q000235:genetics*; D015534:Trans-Activators / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; C485380:MarA protein, Salmonella enterica; D015534:Trans-Activators; C453342:rma protein, Salmonella