title: TIPS versus peritoneovenous shunt in the treatment of medically intractable ascites: a prospective randomized trial.
abstract: OBJECTIVE
  We undertook a prospective randomized clinical trial comparing TIPS to peritoneovenous (PV) shunts in the treatment of medically intractable ascites to establish relative efficacy and morbidity, and thereby superiority, between these shunts.
  
  
  METHODS
  Thirty-two patients were prospectively randomized to undergo TIPS or peritoneovenous (Denver) shunts. All patients had failed medical therapy.
  
  
  RESULTS
  After TIPS versus peritoneovenous shunts, median (mean +/- SD) duration of shunt patency was similar: 4.4 months (6 +/- 6.6 months) versus 4.0 months (5 +/- 4.6 months). Assisted shunt patency was longer after TIPS: 31.1 months (41 +/- 25.9 months) versus 13.1 months (19 +/- 17.3 months) (P < 0.01, Wilcoxon test). Ultimately, after TIPS 19% of patients had irreversible shunt occlusion versus 38% of patients after peritoneovenous shunts. Survival after TIPS was 28.7 months (41 +/- 28.7 months) versus 16.1 months (28 +/- 29.7 months) after peritoneovenous shunts. Control of ascites was achieved sooner after peritoneovenous shunts than after TIPS (73% vs. 46% after 1 month), but longer-term efficacy favored TIPS (eg, 85% vs. 40% at 3 years).
  
  
  CONCLUSIONS
  TIPS and peritoneovenous shunts treat medically intractable ascites. Absence of ascites after either is uncommon. PV shunts control ascites sooner, although TIPS provides better long-term efficacy. After either shunt, numerous interventions are required to assist patency. Assisted shunt patency is better after TIPS. Treating medically refractory ascites with TIPS risks early shunt-related mortality for prospects of longer survival with ascites control. This study promotes the application of TIPS for medically intractable ascites if patients undergoing TIPS have prospects beyond short-term survival.
authors.affiliation: Department of Surgery, University of South Florida, Tampa, Florida, USA. arosemur@hsc.usf.edu
authors.forename: Alexander S
authors.initials: AS
authors.lastname: Rosemurgy
authors.forename: Emmanuel E
authors.initials: EE
authors.lastname: Zervos
authors.forename: Whalen C
authors.initials: WC
authors.lastname: Clark
authors.forename: Donald P
authors.initials: DP
authors.lastname: Thometz
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Black
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Zwiebel
authors.forename: Bruce T
authors.initials: BT
authors.lastname: Kudryk
authors.forename: L Shane
authors.initials: LS
authors.lastname: Grundy
authors.forename: Larry C
authors.initials: LC
authors.lastname: Carey
mesh_terms: D000368:Aged; D001201:Ascites / Q000175:diagnosis* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010536:Peritoneovenous Shunt / Q000379:methods*; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000379:methods*; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016896:Treatment Outcome