[Increase in bispectral index induced by antihyperalgesic dose of ketamine].
We report two cases of sudden increase in Bispectral Index (BIS) after the injection of low-dose ketamine for the prevention of postoperative hyperalgesia. The two patients were anaesthetised with a continuous infusion of remifentanil associated with propofol for one and isoflurane for the other. Changes in BIS occurred while the two patients were in a stable phase of surgery (beginning of parietal closure and suture of an anastomosis) and had a stable target concentration of anaesthetic agents. No others signs of awakening were observed. The BIS value returned progressively to 40-50 despite no increase in target concentration. None of the patients complained of intra-operative recall.
Chaaben
K
K
Département d'anesthésie-réanimation, 4, rue de la Chine, 75970 Paris cedex 020, France.
Marret
E
E
Lamonerie
L
L
Lembert
N
N
Bonnet
F
F
D000368:Aged; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy*; D007530:Isoflurane; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D010880:Piperidines; D015742:Propofol; D011468:Prostatectomy; D019919:Prosthesis Implantation; D000077208:Remifentanil
D000778:Anesthetics, Dissociative; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D010880:Piperidines; D007649:Ketamine; D007530:Isoflurane; D000077208:Remifentanil; D015742:Propofol