title: A new general access to either type of Securinega alkaloids: synthesis of securinine and (-)-allonorsecurinine.
abstract: The syntheses of securinine and (-)-allonorsecurinine have been achieved starting from easily available alpha-amino acid derivatives and using as key steps a RCM and a Heck reaction for the formation of rings D and C, respectively. [reaction: see text]
authors.affiliation: Departament de Química, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain.
authors.forename: Ramon
authors.initials: R
authors.lastname: Alibés
authors.forename: Marta
authors.initials: M
authors.lastname: Ballbé
authors.forename: Félix
authors.initials: F
authors.lastname: Busqué
authors.forename: Pedro
authors.initials: P
authors.lastname: de March
authors.forename: Laia
authors.initials: L
authors.lastname: Elias
authors.forename: Marta
authors.initials: M
authors.lastname: Figueredo
authors.forename: Josep
authors.initials: J
authors.lastname: Font
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D019665:Euphorbiaceae / Q000737:chemistry; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000470:Alkaloids; D001381:Azepines; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; C000785:securinine