[Comparative studies on the resistance of hepatitis B by Syringa extract, IFN and ganyanling in HepG2.2.15 cells].
OBJECTIVE
To explore the effects of Syringa extract, IFN and ganyanling on the the survival rate of HepG2.2.15 cells and the secretion of HBsAg and HBeAg by HepG2.2.15 cells.


METHODS
(3)H-TdR incorporation and ELISA were used to detect respectively the survival rate of HepG2.2.15 cells and levels of HBsAg and HBeAg in culture supernatant of HepG2.2.15 cells after stimulation with 3 drugs.


RESULTS
(1)All of the three drugs decreased the survival rate of HepG2.2.15 cells to the various extent with the increase of doses. The effect of the Syringa extract was between those of IFN and ganyanling. (2)All of the three drugs might suppress the secration of HBsAg and HbeAg by HepG2.2.15 cells in dose-dependent manner, while the the effect of the syringa extract was between those of IFN and ganyanling.


CONCLUSIONS
The Syringa extract is an effective and low toxic anti-hepatitis B drug.
Gao
Shi-Qig
SQ
Department of Gastroenterology, Affiliated Hospital, Jilin Military Medical College, Fourth Military Medical University,Jilin 132013, China.
Niu
Jun-Qi
JQ
Wang
Feng
F
Liu
Xiao-Dong
XD
Jin
Zhen-Xun
ZX
Wang
Yi-Ling
YL
D000998:Antiviral Agents; D006509:Hepatitis B; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D031662:Syringa
D000998:Antiviral Agents; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens