The mRNA cap-binding protein eIF4E in post-transcriptional gene expression.
Eukaryotic initiation factor 4E (eIF4E) has central roles in the control of several aspects of post-transcriptional gene expression and thereby affects developmental processes. It is also implicated in human diseases. This review explores the relationship between structural, biochemical and biophysical aspects of eIF4E and its function in vivo, including both long-established roles in translation and newly emerging ones in nuclear export and mRNA decay pathways.
von der Haar
Tobias
T
Post-transcriptional Control Group, Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK. Tobias.von-der-Haar@umist.ac.uk
Gross
John D
JD
Wagner
Gerhard
G
McCarthy
John E G
JE
D021581:Active Transport, Cell Nucleus; D039561:Eukaryotic Initiation Factor-4E / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D011485:Protein Binding; D014176:Protein Biosynthesis; D039381:RNA Cap-Binding Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D020871:RNA Stability
D039561:Eukaryotic Initiation Factor-4E; D039381:RNA Cap-Binding Proteins