Bromocriptine treatment of prolactinoma restores growth hormone secretion and causes catch-up growth in a prepubertal child.
A 13-year-old Japanese boy with pituitary prolactinoma whose growth had been retarded for more than 2 years was treated with bromocriptine alone for 140 weeks. After treatment, the serum level of prolactin, which was 1200 ng/ml before treatment, returned to normal and the pituitary tumour seen on the initial brain MRI had rapidly decreased in size after 16 weeks of treatment. Thereafter, his height improved (from -2.1 to -1.7 SDS).


CONCLUSIONS
the favourable response obtained in this patient implies that bromocriptine monotherapy can be an effective first-line treatment for children with prolactinoma.
Sakazume
Satoru
S
Department of Paediatrics, Dokkyo University School of Medicine, 2-1-50 Minami-koshigaya, Koshigaya, Saitama, Japan.
Obata
Kazuo
K
Takahashi
Etsurou
E
Yoshino
Atsunori
A
Murakami
Nobuyuki
N
Sakuta
Ryoich
R
Murai
Takayasu
T
Nagai
Toshiro
T
D000293:Adolescent; D001971:Bromocriptine / Q000627:therapeutic use*; D018491:Dopamine Agonists / Q000627:therapeutic use*; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006966:Hyperprolactinemia / Q000150:complications / Q000188:drug therapy*; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications / Q000188:drug therapy*; D015175:Prolactinoma / Q000150:complications / Q000188:drug therapy*
D018491:Dopamine Agonists; D001971:Bromocriptine