CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl beta-carbolin-1-ones.
An expedient synthetic route for 3-aryl beta-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the beta-carbolin-1-ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.
Wang
Shaozhong
S
Department of Chemistry, Nanjing University, Nanjing 210093, PR China.
Sun
Jianwei
J
Yu
Gang
G
Hu
Xiaoyi
X
Liu
Jun O
JO
Hu
Yuefei
Y