Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus.
During lung infection with virus, airway-derived dendritic cells (DC) have been thought to be the dominant cell type involved in acquisition, transport, and direct antigen presentation for cytotoxic T lymphocyte priming. Contrary to this view, we have found that both an airway-derived CD8alpha(-)CD11b(-) DC subset and distinct CD8alpha(+) lymph node resident DC can present class I-restricted antigens after lung infection with influenza virus or herpes simplex virus 1. Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection.
Belz
Gabrielle T
GT
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. belz@wehi.edu.au
Smith
Christopher M
CM
Kleinert
Lauren
L
Reading
Patrick
P
Brooks
Andrew
A
Shortman
Ken
K
Carbone
Francis R
FR
Heath
William R
WR
D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000473:pathology; D006561:Herpes Simplex / Q000276:immunology / Q000473:pathology; D018259:Herpesvirus 1, Human; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D066298:In Vitro Techniques; D008171:Lung Diseases / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D015395:Histocompatibility Antigens Class I