Losartan may prevent the elevation of plasma glucose levels induced by chronic stress.
The effect of angiotensin II antagonist, losartan, on chronic stress-induced elevation of blood glucose levels was investigated in rats. Chronic immobilization stress caused an increase in blood glucose levels in rats. Administration of losartan (3 mg/kg, po) before stress exposure significantly prevented this increment. We suggest that losartan showed this effect by decreasing the excessive sympathetic response to stress. In conclusion, there is a relationship between stress, sympathetic nervous system, and renin-angiotensin system.
Uresin
Yağiz
Y
Istanbul University, Istanbul Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 34390 Capa, Istanbul, Turkey. yagiz@istanbul.edu.tr
Erbaş
Bahar
B
Ozek
Mehmet
M
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D002908:Chronic Disease; D019808:Losartan / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000097:blood* / Q000188:drug therapy*
D001786:Blood Glucose; D019808:Losartan