title: 3,3(')-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group.
abstract: 3,3(')- Oxybis(dimethoxytrityl chloride) (O-DMTCl) was synthesized as a novel, acid-labile bifunctional protecting reagent. The reactions of O-DMTCl with base-protected ribonucleosides afforded unexpectedly 2('),5(')-cyclic protected ribonucleosides in addition to the expected 3('),5(')-cyclic protected ribonucleosides in good yields.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
authors.forename: Natsuhisa
authors.initials: N
authors.lastname: Oka
authors.forename: Yogesh S
authors.initials: YS
authors.lastname: Sanghvi
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Theodorakis
mesh_terms: D002712:Chlorides / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008737:Methyl Chloride / Q000138:chemical synthesis; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis*
chemical_list: D002712:Chlorides; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D012263:Ribonucleosides; D014320:Triphenylmethyl Compounds; D008737:Methyl Chloride