title: Fluorometric variable-temperature kinetics investigations of the transesterification reaction of procaine with aliphatic alcohols.
abstract: OBJECTIVE
  Variable-Temperature Kinetics has been used to obtain the rate constants of the reaction at various temperatures during one kinetic run.
  
  
  METHODS
  Pseudo-first-order rate constants for the transesterification of procaine with aliphatic alcohols ethanol, n-propanol and tert-butanol were obtained by the fluorescence spectroscopy using the variable-temperature kinetics (VTK) method.
  
  
  RESULTS
  The activation parameters of the reactions were calculated (24-28 kcal x mol(-1)). The half-life of the procaine decreases in the ethanol solution compared with the other alcoholic solutions in the presence of sodium ethoxide.
  
  
  CONCLUSIONS
  The investigation time of the reactions is reduced to one-tenth of the one used for usual kinetic methods.
authors.affiliation: Department of Chemistry, Sharif University of Technology, Tehran, Iran.
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Harifi-Mood
authors.forename: Saeed
authors.initials: S
authors.lastname: Haghighi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Gholami
mesh_terms: D000433:1-Propanol / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D004355:Drug Stability; D004951:Esterification; D000431:Ethanol / Q000031:analogs & derivatives* / Q000737:chemistry*; D006207:Half-Life; D007700:Kinetics; D011343:Procaine / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods; D013696:Temperature
chemical_list: D000438:Alcohols; C098088:sodium ethoxide; D000431:Ethanol; D011343:Procaine; D000433:1-Propanol