Close linkage of genes encoding receptors for subgroups A and C of avian sarcoma/leucosis virus on chicken chromosome 28.
Avian sarcoma and leucosis viruses (ASLV) are classified into six major subgroups (A to E and J) according to the properties of the viral envelope proteins and the usage of cellular receptors for virus entry. Subgroup A and B receptors are identified molecularly and their genomic positions TVA and TVB are mapped. The subgroup C receptor is unknown, its genomic locus TVC is reported to be genetically linked to TVA, which resides on chicken chromosome 28. In this study, we used two chicken inbred lines that carry different alleles coding for resistance (TVC(R) and sensitivity (TVC(S)) to infection by subgroup C viruses. A backross population of these lines was tested for susceptibility to subgroup C infection and genotyped for markers from chicken chromosome 28. We confirmed the close linkage between TVA and TVC loci. Further, we have described the position of TVC on chromosome 28 relative to markers from the consensus map of the chicken genome.
Elleder
D
D
Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, Prague, 166 37, Czech Republic.
Plachý
J
J
Hejnar
J
J
Geryk
J
J
Svoboda
J
J
D000483:Alleles; D000818:Animals; D001358:Avian Sarcoma Viruses / Q000145:classification / Q000235:genetics*; D002645:Chickens / Q000235:genetics* / Q000821:virology; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D017931:DNA Primers; D018895:Microsatellite Repeats / Q000235:genetics; D010641:Phenotype; D011991:Receptors, Virus / Q000235:genetics*; D014759:Viral Envelope Proteins / Q000235:genetics*
D017931:DNA Primers; D011991:Receptors, Virus; D014759:Viral Envelope Proteins