Innate immune recognition of microbes through Nod1 and Nod2: implications for disease.
Nod1 and Nod2 are cytosolic proteins involved in intracellular recognition of microbes and their products. Recently, it was shown that these proteins recognize different moieties of bacterial peptidoglycan (PGN) mediating non-specific pathogen resistance and possibly generating signals for the adaptive immune response. Moreover, mutations in the gene encoding Nod2 are associated with increased susceptibility to chronic inflammatory disorders.
Carneiro
Leticia A M
LA
Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, avenue 28-de Setembro, 87-Fundos-3(o) andar, 20550-030 Rio de Janeiro, Brazil.
Travassos
Leonardo H
LH
Philpott
Dana J
DJ
D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology*; D017209:Apoptosis; D001419:Bacteria / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D010457:Peptidoglycan / Q000276:immunology / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D047908:Intracellular Signaling Peptides and Proteins; C119067:NOD1 protein, human; C429018:NOD2 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D010457:Peptidoglycan