title: Isolated splenic metastasis from colon cancer.
abstract: Solid-tumor metastases of the spleen are rare and usually associated with disseminated disease. There are only seven reports in literature of isolated splenic metastases from colorectal carcinoma, which generally metastasize to regional lymphonodes, liver and abdominal peritoneum. We report a case of isolated splenic metastasis in a 55-year-old woman who had undergone left hemicolectomy, lymphadenectomy and chemotherapy 18 months earlier for adenocarcinoma of the sigmoid colon with positive pericolic and inter-aortocaval lymphonodes. This is the eighth documented case of isolated splenic metastasis from colon cancer. Previously reported cases of this type are reviewed along with the mechanism underlying neoplastic spread to the spleen.
authors.affiliation: Institute of Semeiothic Surgery, Dept. of Surgery, Catholic University Sacread Heart, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cavallaro
authors.forename: P
authors.initials: P
authors.lastname: Modugno
authors.forename: M
authors.initials: M
authors.lastname: Specchia
authors.forename: A E
authors.initials: AE
authors.lastname: Pontenza
authors.forename: V
authors.initials: V
authors.lastname: Loschiavo
authors.forename: R
authors.initials: R
authors.lastname: Colli
authors.forename: L
authors.initials: L
authors.lastname: Lauriola
authors.forename: C
authors.initials: C
authors.lastname: Barone
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012811:Sigmoid Neoplasms / Q000473:pathology; D013154:Spleen / Q000473:pathology*; D013160:Splenic Neoplasms / Q000556:secondary*; D014057:Tomography, X-Ray Computed