Effects of smoking on nitric oxide synthesis in epicardial normal and atheromatous coronary arteries.
The effects of an intracoronary infusion of N(G)-monomethyl-L-arginine (LNMMA) followed by intracoronary administration of nitroglycerin in non-stenotic proximal and distal coronary segments were studied in 11 patients with coronary artery disease and in 19 subjects with "normal arteriograms". In normal subjects, LNMMA induced significant constriction (p<0.01) of proximal and distal vessels in non-smokers and smokers. In normal non-smokers, the reduction in coronary luminal diameter of proximal segments was significantly greater compared to normal smokers (p<0.05). In patients with coronary artery disease, LNMMA induced significant constriction of proximal and distal vessels in smokers, and only distal constriction in non-smokers (p<0.01). The reduction in coronary luminal diameter of the distal segments in normal smokers, and in both groups in patients with coronary artery disease was significantly greater compared with proximal segments (p<0.05). Therefore, the difference in vasomotor response to LNMMA in relation to smoking is localised to the proximal coronary segments.
Tentolouris
Costas
C
Hippokration Hospital, Athens University Medical School, Greece.
Tousoulis
Dimitris
D
Davies
Graham
G
Tsioufis
Costas
C
Kallikazaros
Ioannis
I
Michailidis
Andreas
A
Trikas
Athanasios
A
Toutouzas
Pavlos
P
Stefanadis
Christodoulos
C
D000328:Adult; D001158:Arteries / Q000378:metabolism* / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis*; D010496:Pericardium / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D012907:Smoking / Q000009:adverse effects*; D013223:Statistics as Topic; D013599:Systole / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014666:Vasomotor System / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology
D009569:Nitric Oxide