[Isoprostanes: a putative key role in vascular diseases].
OBJECTIVE
Isoprostanes are arachidonic acid metabolites produced by a free-radical-dependent mechanism.


BACKGROUND
The 15-series F2-isoprostanes and some 15-series E2-isoprostanes mediate vasoconstriction in different vascular beds and species. Furthermore, 15-F2t-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. In clinical studies, 15-F2t-IsoP levels are increased in vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation.


CONCLUSIONS
Whether the effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated.
Cracowski
J-L
JL
Laboratoire de pharmacologie, HP2, faculté de médecine de Grenoble, domaine de la Merci, 38700 La Tronche, France. jean-luc.cracowski@ujf-grenoble.fr
D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D028421:Isoprostanes / Q000502:physiology*; D015227:Lipid Peroxidation; D014652:Vascular Diseases / Q000378:metabolism / Q000503:physiopathology*
D015415:Biomarkers; D028421:Isoprostanes