title: [Clinical study of plasma urotensin II in patients with coronary heart disease].
abstract: OBJECTIVE
  To investigate the changes in plasma urotensin II(U II) expression levels in patients with coronary heart disease (CHD).
  
  
  METHODS
  Plasma U II levels in 50 CHD patients with coronary stenosis indicated by coronary angiography and 20 healthy subjects were determined by radio immunoassay.
  
  
  RESULTS
  Venous plasma U II levels were significantly lowered in CHD patients in comparison with the healthy subjects (1.61+/-1.02 pg/ml vs 3.70+/-1.30 pg/ml, P=0.000). In the CHD patient group, significantly differences were noted in the U II levels between patients with stable angina (2.62+/-1.20 pg/ml), unstable angina (1.39+/-0.80 pg/ml) and acute myocardial infarction (AMI, 1.04+/-0.45 pg/ml, P=0.004). CHD patients with coronary artery occlusion and those with only coronary stenosis had comparable venous plasma U II levels (1.29+/-1.02 pg/ml vs 1.76+/-1.00 pg/ml, P=0.131), whereas the patients with restenosis after percutaneous transluminal coronary angioplasty (PTCA) had higher U II levels than the other subjects in the CHD patient group (2.28+/-0.94 pg/ml vs 1.40+/-0.96 pg/ml, P=0.008), and the femoral plasma U II levels were significantly elevated after PTCT, increasing from 1.18+/-1.14 pg/ml to a postoperative level of 2.22+/-1.77 pg/ml (P=0.001).
  
  
  CONCLUSIONS
  U II might play a role in the pathophysiological process of CHD and can be involved in the restenosis after angioplasty.
authors.affiliation: Department of Cardiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. fshjxjj@163.com
authors.forename: Shi-Hu
authors.initials: SH
authors.lastname: Fang
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Li
authors.forename: Hong-Chao
authors.initials: HC
authors.lastname: Wu
authors.forename: Chao-Shu
authors.initials: CS
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Hai-Chao
authors.initials: HC
authors.lastname: Liu
authors.forename: Quan-Neng
authors.initials: QN
authors.lastname: Yan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014579:Urotensins / Q000097:blood*
chemical_list: D014579:Urotensins; C029677:urotensin II