title: [The study of influencing cellular dynamics of gynostemma pentaphyllum on golden hamster cheek pouch premalignancy]
abstract: Studying premalignancy is an important field of conquering cancer.The aim to study the mechanics of oral mucosal premalignant formation and seek effective drug which could prevent and block cancer,Gynostemma Pentaphyllum(GP) was applies to block carcinomatous conversion of golden hamster cheek pouch by Salley's way.Using light microscopic observation and proliferating cell nuclear antigen(PCNA) as well as bromodeoxyuridine(BrdU)(PCNA AND BrdU are immunohistochemistry techniques),GPs effect was observed dynamically.We found that GP could delay the presence of leukoplakia and decrease the rate of presence as well as cancer-causing rate. The positive cells of taking drug group PCNA and BrdU were lower than model group significantly and in a lower condition all the time.It is illustrated that GP has the effect of preventing cancer and inhibiting cellular dysplasia.
authors.affiliation: Department of Oral Medicine, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University. Shanghai 200011,China.
authors.forename: Z T
authors.initials: ZT
authors.lastname: Zhou
authors.forename: W N
authors.initials: WN
authors.lastname: Xu
authors.forename: S L
authors.initials: SL
authors.lastname: Zhang
authors.forename: Y M
authors.initials: YM
authors.lastname: Zhou
authors.forename: Z G
authors.initials: ZG
authors.lastname: Jin
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: W G
authors.initials: WG
authors.lastname: Li