title: Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163.
abstract: BACKGROUND
  Crohn's disease is associated with an increased number of macrophages in ileal and colonic mucosa. Data on macrophages in gut mucosa of patients with spondyloarthritis (SpA) are scarce.
  
  
  OBJECTIVE
  To investigate macrophages and other antigen presenting cells in gut mucosa from patients with SpA and Crohn's disease, given the relationship between both entities.
  
  
  METHODS
  Biopsy specimens from patients with SpA, Crohn's disease, ulcerative colitis, and from controls were immunohistochemically stained with different markers for macrophages and dendritic cells. Slides were scored semiquantitatively on a four point scale.
  
  
  RESULTS
  SpA and Crohn's disease were associated with large numbers of CD68+ macrophages. Colon mucosa of both patients with SpA and Crohn's disease, but not ulcerative colitis, showed increased numbers of macrophages expressing the scavenger receptor CD163.
  
  
  CONCLUSIONS
  Macrophages expressing the scavenger receptor CD163 are increased in colonic mucosa in SpA and in Crohn's disease, highlighting the relationship between these entities. The increased number of CD163+ macrophages in colon mucosa of patients with SpA suggests this is another argument for a role of macrophage scavenger receptors in this group of diseases.
authors.affiliation: Department of Pathology, University Hospital, Ghent University, 5 Blok A, De Pintelaan 185, B-9000 Gent, Belgium. pieter.demetter@ugent.be
authors.forename: P
authors.initials: P
authors.lastname: Demetter
authors.forename: M
authors.initials: M
authors.lastname: De Vos
authors.forename: J A
authors.initials: JA
authors.lastname: Van Huysse
authors.forename: D
authors.initials: D
authors.lastname: Baeten
authors.forename: L
authors.initials: L
authors.lastname: Ferdinande
authors.forename: H
authors.initials: H
authors.lastname: Peeters
authors.forename: H
authors.initials: H
authors.lastname: Mielants
authors.forename: E M
authors.initials: EM
authors.lastname: Veys
authors.forename: F
authors.initials: F
authors.lastname: De Keyser
authors.forename: C A
authors.initials: CA
authors.lastname: Cuvelier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000276:immunology; D003106:Colon / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007413:Intestinal Mucosa / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000378:metabolism*; D025241:Spondylarthritis / Q000276:immunology*; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D006684:HLA-DR Antigens; D011956:Receptors, Cell Surface