The simplex (differentiated) variant of vulvar intraepithelial neoplasia.
BACKGROUND
The simplex (differentiated) variant of vulvar intraepithelial neoplasia is rarely reported. It is regarded as more likely than "classic" carcinoma in situ to be associated with invasion and can be easily mistaken for benign lesions.


OBJECTIVE
The objective was to present a case of simplex variant of vulvar intraepithelial neoplasia in a 67-year-old woman that was initially misdiagnosed as lichen simplex chronicus.


METHODS
A case report is reported and the literature is reviewed.


RESULTS
Surgical excision with a free margin of 5 mm was performed and no evidence of recurrence was noted during the follow-up period of 6 months.


CONCLUSIONS
The simplex vulvar intraepithelial neoplasia is an easily overlooked premalignant disease, and it can be cured with surgical treatment if diagnosed correctly and early.
Hsieh
Meng-Yueh
MY
Department of Dermatology, Chang-Gung Memorial Hospital, Kaohsiung, Taiwan.
Kuo
Hung-Wen
HW
D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009450:Neurodermatitis / Q000175:diagnosis / Q000473:pathology; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology