Polymer-coated liposomes resistant to enzymatic hydrolysis.
A polymerizable electrolyte, 2-aminoethyl 1,6-heptadien-4-yl phosphate (AEHDP), which has the same hydrophilic head group as naturally occurring phospholipids, was prepared. Five equivalents of AEHDP were added to a suspension of liposomes (closed bilayer vesicles made of phospholipids) and layered on the liposomes. After polymerization by UV irradiation, the resulting polymer-coated liposomes were resistant to hydrolysis of their constituent phospholipids by phospholipase A2.
Gotoh
Takeshi
T
Department of Materials-Process Engineering & Applied Chemistry for Environments, Akita University, 1-1 Tagata Gakuen-cho, Akita 010-8502, Japan. tgotoh@ac5.as.akita-u.ac.jp
Hozawa
Mitsunori
M
D000327:Adsorption; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004983:Ethanolamines / Q000737:chemistry*; D006868:Hydrolysis; D008081:Liposomes / Q000737:chemistry*; D008422:Materials Testing; D010755:Organophosphates / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D010741:Phospholipases A / Q000737:chemistry*; D054467:Phospholipases A2; D010743:Phospholipids / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
C495442:2-aminoethyl 1,6-heptadien-4-yl phosphate; D020099:Coated Materials, Biocompatible; D004983:Ethanolamines; D008081:Liposomes; D010755:Organophosphates; D010713:Phosphatidylcholines; D010743:Phospholipids; D011108:Polymers; D010741:Phospholipases A; D054467:Phospholipases A2