title: Allergen avoidance does not alter airborne cat allergen levels in classrooms.
abstract: BACKGROUND
  Some schools in Sweden offer allergen avoidance classrooms for allergic children with severe asthma. However, the measures commonly used to achieve a reduction in allergen levels have not been properly evaluated. The aim of the present prospective study was to study whether the levels of airborne cat allergen are altered after introducing feasible intervention measures in classrooms, without interfering with peoples' freedom of choice regarding pet ownership.
  
  
  METHODS
  Twenty-five classes, including five established allergy prevention classrooms participated in the study during a school year. After one term, six classes underwent a number of intervention measures recommended by the Swedish National Institute of Public Health. Curtains, upholstery and plants were removed, bookshelves were replaced with cupboards and regular cleaning was increased. Airborne dust was collected weekly (32 weeks) using duplicate Petri dishes (n = 1574) and on six occasions using two personal air samplers in each class (n = 264).
  
  
  RESULTS
  Airborne cat allergen levels were showing a similar variability throughout the whole study in all classes. Despite extensive measures in order to reduce allergen exposure, cat allergen levels were unaltered in the six classes after intervention. Allergen levels were not significantly lower in the established allergy prevention classes, compared with the other classes. Cat allergen levels differed, however, significantly between classes with few and many cat owners (P < 0.05).
  
  
  CONCLUSIONS
  We conclude that the recommended allergen avoidance measures used in this study did not reduce airborne cat allergen. It seems plausible that measures that fail to reduce allergen levels also fail to influence health status in allergic children but this remains to be shown.
authors.affiliation: Lung and Allergy Research, National Institute of Environmental Medicine, Karolinska Institutet, Box 287, S-171 77 Stockholm, Sweden.
authors.forename: A-S
authors.initials: AS
authors.lastname: Karlsson
authors.forename: A
authors.initials: A
authors.lastname: Renström
authors.forename: M
authors.initials: M
authors.lastname: Hedrén
authors.forename: K
authors.initials: K
authors.lastname: Larsson
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis*; D000485:Allergens / Q000032:analysis*; D000818:Animals; D002415:Cats / Q000276:immunology*; D002648:Child; D004780:Environment, Controlled; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D011446:Prospective Studies; D012574:Schools; D013548:Sweden
chemical_list: D000393:Air Pollutants; D000485:Allergens