Hsp90 invades the outside.
Metalloproteases are required for the invasive nature of cancer cells. Surprisingly, the cytosolic molecular chaperone Hsp90 is now shown to promote maturation of the extracellular metalloprotease MMP2. This finding extends the multiplicity of roles assigned to the Hsp90 family to a new function outside the cell.
Picard
Didier
D
D000951:Antigens, Neoplasm / Q000378:metabolism; D001485:Basement Membrane / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D005109:Extracellular Matrix / Q000378:metabolism; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000235:genetics*
D000951:Antigens, Neoplasm; D018841:HSP90 Heat-Shock Proteins; C092306:TRAP1 protein, human; C052646:sarcoma glycoprotein gp96 rejection antigens; D020778:Matrix Metalloproteinase 2