title: Biological properties of staphylococcal enterotoxin-like toxin type R.
abstract: We investigated the biological properties of a novel staphylococcal enterotoxin-like putative toxin, staphylococcal enterotoxin-like toxin type R (SElR). Major histocompatibility complex class II molecules were required for T-cell stimulation by SElR. SElR stimulated T cells bearing receptors Vbeta 3, 11, 12, 13.2, and 14. These results suggested that SElR acts as a superantigen.
authors.affiliation: Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, Ueda 3-18-8, Morioka, Iwate 020-8550, Japan. omo@iwate-u.ac.jp
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Omoe
authors.forename: Ken'ichi
authors.initials: K
authors.lastname: Imanishi
authors.forename: Dong-Liang
authors.initials: DL
authors.lastname: Hu
authors.forename: Hidehito
authors.initials: H
authors.lastname: Kato
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takahashi-Omoe
authors.forename: Akio
authors.initials: A
authors.lastname: Nakane
authors.forename: Takehiko
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Shinagawa
mesh_terms: D000818:Animals; D004768:Enterotoxins / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D011817:Rabbits; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013211:Staphylococcus aureus / Q000276:immunology* / Q000378:metabolism; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D004768:Enterotoxins; D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens