title: [An experimental study of the therapeutic effect of interleukin-2 and interleukin-12 with and without amphotericin B on pulmonary fungal infection].
abstract: OBJECTIVE
  To study the therapeutic effect of interleukin-2 (IL-2) and interleukin-12 (IL-12) with and without amphotericin B on pulmonary fungal infection of mice.
  
  
  METHODS
  A mouse model of pulmonary invasive aspergillus fumigatus (IPA) infection was established and the mice were divided into different groups, treated with IL-2 and IL-12 with and without amphotericin B. The survival number of mice in 15 days and the colony count of lung tissue in the different groups were observed.
  
  
  RESULTS
  IL-2, IL-12 and amphotericin B showed synergistic effect in prolonging the survival of the infected mice and reducing the colony count in the lung tissue.
  
  
  CONCLUSIONS
  IL-2 and IL-12 are effective adjuvant therapeutic agents in the immunosuppressed hosts.
authors.affiliation: Department of Internal Medicine, Huang Pu Hospital of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, China.
authors.forename: Chang-ran
authors.initials: CR
authors.lastname: Zhang
authors.forename: Ying-chun
authors.initials: YC
authors.lastname: Tang
authors.forename: K
authors.initials: K
authors.lastname: Kawakami
authors.forename: Tian-tuo
authors.initials: TT
authors.lastname: Zhang
authors.forename: Kou-xing
authors.initials: KX
authors.lastname: Zhang
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: Zhu
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D015169:Colony Count, Microbial; D004357:Drug Synergism; D018664:Interleukin-12 / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation
chemical_list: D000935:Antifungal Agents; D007376:Interleukin-2; D018664:Interleukin-12; D000666:Amphotericin B