title: [Early-stage hemodynamic changes in dogs with gunshot wound in seawater].
abstract: OBJECTIVE
  To investigate the hemodynamic changes in the early stages of gunshot wound of dogs in seawater for exploring early treatment protocol.
  
  
  METHODS
  Fourteen conventional Beagles models undergoing gunshot wound in seawater were used along with another 2 dogs receiving the wound on land to serve as control. After the dogs were rescued from the seawater, the respiration (R), heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central venous pressure (CVP), pulmonary arterial wedge pressure (PAWP), and cardiac output (CO) were measured continuously in the early stages of the wound (53.62+/-12.19 min following injury), followed by statistical analysis of the results.
  
  
  RESULTS
  Compared with the control group, the hemodynamic disturbance of the dogs receiving the wound in seawater was relatively severe during the first 15 min of the wound. The mortality tended to descend relevant to the position of the wounds, in the order of the head, chest, abdomen and limbs.
  
  
  CONCLUSIONS
  Gunshot wound in seawater may cause severe hemodynamic changes, resulting in progressive dysfunction of circulation and high mortality rate. Early treatment should be targeted at hemodynamic stabilization in accordance to the characteristic changes during the early stages of the wound.
authors.affiliation: Department of Pathology, First Military Medical University, Guangzhou 510515, China. mhgl2008@yahoo.com.cn
authors.forename: Hui
authors.initials: H
authors.lastname: Meng
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Gao-wang
authors.initials: GW
authors.lastname: Liu
authors.forename: Tian-ling
authors.initials: TL
authors.lastname: Zhu
authors.forename: Jun-xin
authors.initials: JX
authors.lastname: Zhang
authors.forename: Zeng-rong
authors.initials: ZR
authors.lastname: Wu
authors.forename: Hai-ji
authors.initials: HJ
authors.lastname: Bu
mesh_terms: D000818:Animals; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D012623:Seawater; D014948:Wounds, Gunshot / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy