title: Types of anaemic crises in paediatric patients with sickle cell anaemia seen in Enugu, Nigeria.
abstract: BACKGROUND
  Anaemic crises in paediatric patients with sickle cell anaemia are major causes of morbidity and mortality. Some children admitted to hospitals' emergency rooms or paediatric wards of the hospitals with severe anaemia die before blood transfusion.
  
  
  OBJECTIVE
  A total of 108 episodes of anaemic crises were prospectively evaluated in 108 patients with sickle cell anaemia attending the paediatric sickle cell clinic of the University of Nigeria Teaching Hospital, Enugu, Nigeria.
  
  
  RESULTS
  Hyper-haemolytic crises were the commonest types of anaemic crises in the patients studied. The mean haemoglobin concentration of 44.66 (SD 6.42) g/l in crises was significantly lower than the mean steady state level of 78.69 (SD 8.50) g/l. Reticulocytes, unconjugated serum bilirubin concentrations, and the presence of nucleated red blood cells were also increased. About 4.6% of patients were not jaundiced at presentation even though they were profoundly anaemic. Their haematological indices gradually returned to normal without marked changes in their serum bilirubin concentrations. These patients were probably in the early recovery phase of aplastic crises. The classical presentation of acute splenic sequestration crisis with a rapidly enlarging spleen and hypotension was not observed. This was probably because of its precipitate nature and accompanying circulatory collapse, which carried a high mortality rate. Minor forms of sequestration crises may have occurred in the liver and spleen.
  
  
  CONCLUSIONS
  Malaria appeared to have played a role in precipitating some of the hyper-haemolytic episodes. Further studies to elucidate this role are required so that appropriate recommendations regarding malaria prophylaxis can be made in patients with sickle cell anaemia.
authors.affiliation: Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria. anthonyjuwah@doctors.org.uk
authors.forename: A I
authors.initials: AI
authors.lastname: Juwah
authors.forename: E U
authors.initials: EU
authors.lastname: Nlemadim
authors.forename: W
authors.initials: W
authors.lastname: Kaine
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications* / Q000628:therapy; D000962:Antimalarials / Q000008:administration & dosage; D001663:Bilirubin / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000008:administration & dosage; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007565:Jaundice / Q000150:complications; D008288:Malaria / Q000150:complications; D008297:Male; D009549:Nigeria; D011446:Prospective Studies; D017701:Reticulocyte Count
chemical_list: D000962:Antimalarials; D006454:Hemoglobins; D002738:Chloroquine; D001663:Bilirubin