title: Pathogenesis of endometriosis.
abstract: Many women harbour spots of peritoneal endometriosis without having any symptoms; this is referred to as the phenomenon endometriosis. Some of these women go on to develop symptomatic endometriosis. Although we know the factors potentially involved in the aetiology and pathogenesis of endometriosis, the exact mechanism by which the phenomenon endometriosis develops into the disease endometriosis, with its associated signs and symptoms, remain obscure. The widely accepted theory is Sampson's transplantation theory. Recent findings indicate that certain properties of the endometrium, and the influence of the local environment, are crucial in the development of endometriosis. Early endometriosis lesion formation is described in detail, as this seems to be a key process in the development of peritoneal endometriosis.
authors.affiliation: Department of Gynaecology and Obstetrics, Research Institute GROW, University Hospital Maastricht, Maastricht, The Netherlands.
authors.forename: Annemiek W
authors.initials: AW
authors.lastname: Nap
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Groothuis
authors.forename: Ayse Y
authors.initials: AY
authors.lastname: Demir
authors.forename: Johannes L H
authors.initials: JL
authors.lastname: Evers
authors.forename: Gerard A J
authors.initials: GA
authors.lastname: Dunselman
mesh_terms: D004715:Endometriosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D004717:Endometrium / Q000098:blood supply / Q000201:enzymology; D004967:Estrogens / Q000502:physiology; D005260:Female; D006801:Humans; D020782:Matrix Metalloproteinases / Q000502:physiology; D008598:Menstruation; D009389:Neovascularization, Pathologic; D010532:Peritoneal Diseases / Q000209:etiology*
chemical_list: D004967:Estrogens; D020782:Matrix Metalloproteinases