An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma: a case-control study.
In a case-control study, we studied the effect of a single nucleotide polymorphism in the IL-8 promoter on the risk of the development of AIDS-related Kaposi's sarcoma (KS). KS developed in 46% of individuals with the TT genotype and in 66% of AA/AT genotypes (P=0.038). Patients with TT genotype were rarely affected with visceral KS (7% versus 36%; P=0.06), which suggests that carriers of the TT genotype are protected from (severe) KS development.
van der Kuyl
Antoinette C
AC
Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, The Netherlands.
Polstra
Abeltje M
AM
Weverling
Gerrit Jan
GJ
Zorgdrager
Fokla
F
van den Burg
Remco
R
Cornelissen
Marion
M
D017088:AIDS-Related Opportunistic Infections / Q000235:genetics; D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D016022:Case-Control Studies; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000235:genetics*
D016209:Interleukin-8