[Glomerular-type proteinuria in hantavirus nephritis].
BACKGROUND
Infection with hantavirus of the Puumala type is known to cause severe illness, fever, loin pain and impaired vision. Tubulointerstitial nephritis leads to acute renal failure.


METHODS
In four patients presenting with hantavirus infection and acute renal failure, proteinuria was analyzed by microelectrophoresis to explore possible causes of renal protein loss in hantavirus nephritis. The patients (three men, one woman) presented with a short history of fever, headache, loin pain and acute renal failure (enlarged kidneys in ultrasonography, serum creatinine 7.7/3.4/3.2/7.8 mg/dl, urinary protein excretion 1.7/0.5/1.5/9.0 g/l, IgM antibodies against hantavirus positive in all patients, subtype Puumala). Microelectrophoresis of the urine revealed a major fraction of higher molecular weight proteins such as transferrin and immunoglobulins indicating unselective glomerular-type proteinuria in all four patients. In three renal biopsy specimens obtained, morphology of glomeruli and vasculature was normal as judged by light microscopy. The tubulointerstitium exhibited interstitial hemorrhage and round-cell infiltrates. After 2 weeks, renal function had completely recovered in all patients and no persistent proteinuria developed.


CONCLUSIONS
Hantavirus nephritis may lead to glomerular-type proteinuria. Glomerular morphology may be normal and proteinuria may cease within 2 weeks indicating a transient lesion of the glomerular filtration barrier. Transiently increased glomerular permeability may be caused by an immunologic response to virus infection.
Matthaeus
Tilman
T
Medizinische Klinik I, Kliniken der Stadt Köln, Köln-Merheim. t.matthaeus@uni-koeln.de
Fries
Jochen
J
Weber
Manfred
M
Schulze-Lohoff
Eckhard
E
D058186:Acute Kidney Injury / Q000175:diagnosis*; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000473:pathology; D018778:Hantavirus Infections / Q000175:diagnosis* / Q000473:pathology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007136:Immunoglobulins / Q000652:urine; D007668:Kidney / Q000473:pathology; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D009395:Nephritis, Interstitial / Q000175:diagnosis* / Q000473:pathology; D029262:Puumala virus; D014168:Transferrin / Q000652:urine
D007136:Immunoglobulins; D014168:Transferrin