title: Comparison of special interest computed tomography, endosonography and histopathological stage of oesophageal cancer.
abstract: OBJECTIVE
  To assess the strength of agreement between the perceived pre-operative stage of oesophageal tumours as determined by spiral computed tomography (CT) and endoscopic ultrasound (EUS), both alone and in combination, with the histopathological stage.
  
  
  METHODS
  Sixty patients with oesophageal cancer underwent both pre-operative CT and EUS performed by two consultant radiologists with a special interest in upper gastrointestinal radiology. The strength of the agreement between the radiological stage and the histopathological stage was determined by means of the weighted Kappa statistic (Kw).
  
  
  RESULTS
  Sensitivity for T and N stages was 58% and 79% for CT, and 72% and 91% for EUS. Specificity for T and N stages was 80% and 84% for CT, and 85% and 68% for EUS. Kw for T and N stages was 0.455 (p=0.0001) and 0.603 (p=0.0001) for CT compared with 0.604 (p=0.0001) and 0.610 (p=0.0001) for EUS. In patients when CT and EUS agreed regarding the T and N stages, the strength of agreement between the radiological and the histopathological stage was greater (Kw T 0.613 (p=0.0001), Kw N 0.781 (p=0.0001)).
  
  
  CONCLUSIONS
  CT and EUS are complimentary techniques for the staging of oesophageal tumours, and these results reinforce the importance of specialist radiology in stage directed management.
authors.affiliation: Department of Surgery, Royal Gwent Hospital, Newport, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Weaver
authors.forename: G R J C
authors.initials: GR
authors.lastname: Blackshaw
authors.forename: W G
authors.initials: WG
authors.lastname: Lewis
authors.forename: P
authors.initials: P
authors.lastname: Edwards
authors.forename: S A
authors.initials: SA
authors.lastname: Roberts
authors.forename: G V
authors.initials: GV
authors.lastname: Thomas
authors.forename: M C
authors.initials: MC
authors.lastname: Allison
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000648:ultrastructure; D019160:Endosonography / Q000379:methods; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods* / Q000592:standards; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods