[Synthesis and immunomodulating activity of new diglycopeptides of of glycyrrhizinic acid and it's 30-methyl ester].
New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
Kondratenko
R M
RM
Bashkortostan State Medical University, Ufa, Bashkortostan, 450074 Russia.
Baltina
L A
LA
Vasil'eva
E V
EV
Nasyrov
Kh M
KhM
Kireeva
R M
RM
Baschenko
N Zh
NZh
Fridman
S M
SM
Baltina
L A
LA
Tolstikov
G A
GA
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004987:Ethers / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice
D000276:Adjuvants, Immunologic; D004987:Ethers; D006020:Glycopeptides; D019695:Glycyrrhizic Acid