title: Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.
abstract: PDCD4 is a new tumor suppressor gene. In the current study, we show that overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation. This is most likely caused by a PDCD4-induced downregulation of carbonic anhydrase type II which catalyzes the production of bicarbonate, a fundamental substrate for many cellular pathways.
authors.affiliation: Clinical Research Unit for Gastrointestinal Endocrinology, University of Marburg, Marburg, Germany. goeke@mailer.uni-marburg.de
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Göke
authors.forename: Cornelia
authors.initials: C
authors.lastname: Gregel
authors.forename: Alexandra
authors.initials: A
authors.lastname: Göke
authors.forename: Rudolf
authors.initials: R
authors.lastname: Arnold
authors.forename: Harald
authors.initials: H
authors.lastname: Schmidt
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lankat-Buttgereit
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D002276:Carcinoid Tumor; D045744:Cell Line, Tumor; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D010190:Pancreatic Neoplasms; D016601:RNA-Binding Proteins / Q000502:physiology*
chemical_list: D051017:Apoptosis Regulatory Proteins; C114487:PDCD4 protein, human; D016601:RNA-Binding Proteins