title: Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes.
abstract: The ezrin/radixin/moesin (ERM) family of actin-binding proteins act both as linkers between the actin cytoskeleton and plasma membrane proteins and as signal transducers in responses involving cytoskeletal remodelling. The Rho family of GTPases also regulate cytoskeletal organisation, and several molecular pathways linking ERM proteins and Rho GTPases have been described. This review discusses recent findings on ERM protein function in leucocytes and how these may be integrated with Rho GTPase signalling.
authors.affiliation: Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, UK.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Ivetic
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Ridley
mesh_terms: D001798:Blood Proteins / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D008840:Microfilament Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000502:physiology*; D000099149:Ezrin
chemical_list: D001798:Blood Proteins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D020741:rho GTP-Binding Proteins; D000099149:Ezrin; C071058:moesin; C071776:radixin