[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].
In agreement with previous data in the literature, our results indicate that serotonin, a monoamine neurotransmitter, can also regulate cell proliferation, cell movements and cell differentiation. We have recently shown that serotonin is required for embryonic heart development. Genetic ablation of the 5-HT2B receptor leads to partial embryonic and postnatal lethality with abnormal heart development. Similar molecular mechanisms seem to be involved in adult cardiomyocytes since mutant mice surviving to adulthood display a dilated cardiomyopathy. Furthermore this receptor appears to be involved in survival of cardiomyocytes. The 5-HT2B receptor is also implicated in systemic hypertension. Furthermore, mice with pharmacological or genetic ablation of 5-HT2B receptor are totally resistant to hypoxia-induced pulmonary hypertension, indicating that this receptor is regulating the pathologic vascular proliferation leading to this disease. Underlying mechanisms are still to be discovered.
Etienne
Nelly
N
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) CNRS, INSERM, Université L. Pasteur de Strasbourg, BP 10142, 67404 Illkirch, France.
Schaerlinger
Bérénice
B
Jaffré
Fabrice
F
Maroteaux
Luc
L
D000328:Adult; D000818:Animals; D002311:Cardiomyopathy, Dilated / Q000235:genetics / Q000378:metabolism; D002470:Cell Survival; D005277:Fenfluramine / Q000009:adverse effects / Q000493:pharmacokinetics; D005318:Fetal Heart / Q000378:metabolism; D005804:Genes, Lethal; D020022:Genetic Predisposition to Disease; D006330:Heart Defects, Congenital / Q000196:embryology / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics; D006976:Hypertension, Pulmonary / Q000209:etiology; D000860:Hypoxia / Q000150:complications; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism; D009928:Organ Specificity; D010196:Pancreatic Elastase / Q000502:physiology; D011651:Pulmonary Artery / Q000473:pathology; D051381:Rats; D044403:Receptor, Serotonin, 5-HT2B / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012701:Serotonin / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D053773:Transforming Growth Factor beta1
D044403:Receptor, Serotonin, 5-HT2B; C508960:TGFB1 protein, human; C508961:Tgfb1 protein, mouse; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D005277:Fenfluramine; D012701:Serotonin; D010196:Pancreatic Elastase