Immunohistochemical studies in the differential diagnosis of small round cell soft tissue tumors.
In this review the authors focus on the differential diagnosis of small round cell tumors of soft tissue origin, giving emphasis on their specific immunohistochemical profiles. The sources of diagnostic errors and misinterpretations of the results of immunohistochemical staining are discussed in detail. It is thorough knowledge of specific characteristics of each tumor and appropriate interpretation of different staining techniques that will lead to precise classification of any given tumor, thus allowing accurate determination of prognosis and implementation of the optimal treatment.
Papadimitriou
John C
JC
University of Maryland, Department of Pathology, Maryland 21201-1595, USA.
Nikitakis
Nikolaos
N
Armand
Ray
R
D014408:Biomarkers, Tumor; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D006801:Humans; D007150:Immunohistochemistry; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology
D014408:Biomarkers, Tumor