title: In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts.
abstract: We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ.
authors.affiliation: Laboratorio de Neuropsicofarmacología, Instituto Nacional de Neurología y Neurocirugía, Facultad de Química, Insurgentes Sur 3877, Col. La Fama, Tlalpan 14269, México City, México.
authors.forename: Francisca
authors.initials: F
authors.lastname: Palomares
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Palencia
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Pérez
authors.forename: Dinora
authors.initials: D
authors.lastname: González-Esquivel
authors.forename: Nelly
authors.initials: N
authors.lastname: Castro
authors.forename: Helgi Jung
authors.initials: HJ
authors.lastname: Cook
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000980:Antiplatyhelmintic Agents / Q000494:pharmacology*; D003551:Cysticercosis / Q000469:parasitology* / Q000473:pathology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011223:Praziquantel / Q000494:pharmacology*; D013552:Swine; D013621:Taenia / Q000187:drug effects*; D041201:Taenia solium / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D000980:Antiplatyhelmintic Agents; D011223:Praziquantel; D015766:Albendazole