title: The mystery of fungal infection in the guttural pouches.
abstract: Advances in the understanding of guttural pouch physiology and novel therapeutic approaches to mycotic infections in the horse are reviewed. It is suggested that the guttural pouches may contribute to the regulation of arterial blood temperature, cooling the circulation to the brain to below body temperature. Aspergillus spp. is the major organism found in a guttural pouch affected with mycosis but it is unclear why this agent becomes aggressive. Conventional therapy aims to prevent fatal haemorrhage and to treat any neurological lesions but it is desirable to try to prevent the disease. A technique consisting of inserting a transarterial coil into the internal carotid, external carotid and maxillary arteries in normal and affected horses has been reported to be rapid, safe and effective in occluding the arteries and in inducing regression of the mycotic lesions without adjunctive medical treatment. When faced with acute and uncontrollable epistaxis in the field, the most effective means to reduce haemorrhage is probably the occlusion of both common carotid arteries. However, how such arterial occlusions can result in the successful management of guttural pouch mycosis without antifungal medication remains a mystery.
authors.affiliation: Département Hippique, Ecole Nationale Vétérinaire de Lyon, B.P.83, F-69280 Marcy l'Etoile, France. o.lepage@vet-lyon.fr
authors.forename: O M
authors.initials: OM
authors.lastname: Lepage
authors.forename: M-F
authors.initials: MF
authors.lastname: Perron
authors.forename: J-L
authors.initials: JL
authors.lastname: Cadoré
mesh_terms: D000818:Animals; D001228:Aspergillosis / Q000628:therapy / Q000662:veterinary*; D017536:Carotid Artery, Common; D004427:Ear Diseases / Q000628:therapy / Q000662:veterinary*; D004621:Embolization, Therapeutic / Q000379:methods / Q000662:veterinary; D004844:Epistaxis / Q000628:therapy / Q000662:veterinary; D005064:Eustachian Tube; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D012141:Respiratory Tract Infections / Q000628:therapy / Q000662:veterinary*