[Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].
OBJECTIVE
To provide basic data for the synthesis of new sinomenine derivatives.


METHODS
The C ring in sinomenine was modified.


RESULTS
Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities.


CONCLUSIONS
Modification of the C ring in sinomenine should be worthy to be studied further.
Ye
Xian-rong
XR
Institute of Materia Medica Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. xianrongye@imm.ac.cn
Yan
Ke-xu
KX
Wu
Ke-mei
KM
Feng
Xiao-zhang
XZ
Huang
Yu-ming
YM
Qiu
Ping
P
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000473:pathology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D009019:Morphinans / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D010147:Pain Measurement; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D032841:Sinomenium / Q000737:chemistry*
C488562:6,7-dihydroxy-7,8- dihydro-sinomenine; C488563:7beta-methoxy-dihydro-sinomenine; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009019:Morphinans; C009271:sinomenine