title: New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama.
abstract: Five new isoprenylated flavones, artochamins A-E (1-5), together with eight known flavones (6-13), were isolated from the roots of Artocarpus chama. All structures were elucidated by spectroscopic methods. Artonin E (12) showed strong cytotoxicity against 1A9 (ovarian), significant activity against MCF-7 (breast adenocarcinoma), and moderate activity against HCT-8 (ileocecal) and MDA-MB-231 (breast adenocarcinoma) tumor cell lines. Artochamin C (3) was more potent against MCF-7, 1A9, HCT-8, and SK-MEL-2 (melanoma) than A549 (lung carcinoma), KB (epidermoid carcinoma of the nasopharynx), and its drug-resistant (KB-VIN) variant. Artocarpin (6) displayed weak but relatively broad inhibitory effects compared with 3 and 12.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People's Republic of China.
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Dao-Feng
authors.initials: DF
authors.lastname: Chen
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Kenneth F
authors.initials: KF
authors.lastname: Bastow
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nakanish
authors.forename: Xi-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031622:Artocarpus / Q000737:chemistry*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D005419:Flavonoids