[A cumulative renal survival analysis of 495 cases of IgA nephropathy].
OBJECTIVE
To study the long-term outcome of idiopathic IgA nephropathy and analyze its clinical and histological prognostic factors.


METHODS
We conducted a retrospective analysis of 495 cases of IgA nephropathy patients in our hospital from 1986 to 2002. Renal survival was analyzed by Kaplan-Meier method, univariate analysis and multivariate Cox regression analysis.


RESULTS
The cumulative renal survival rate was 85% at 10 years and 70.9% at 15 years. Univariate analysis found the following parameters at the time of biopsy to be significantly correlated with poor renal survival: serum creatinine > or = 133 micromol/L (P < 0.001), hypertension (P < 0.05), 24-hour urine protein excretion > or = 3 g (P < 0.001), histological subclass V (P < 0.001), and without the history of gross hematuria (P < 0.05). The Cox regression analysis showed that only the presence of hypertension (HR=7.75, 95%CI 1.02 to approximately 2.19) and serum creatinine level (HR=1.49, 95%CI 1.54 to approximately 38.90) were independent prognostic indicators.


CONCLUSIONS
The findings in Chinese IgA nephropathy patients are in agreement with the results of many other studies worldwide.
Qin
Yan
Y
Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Li
Xue-wang
XW
Li
Hang
H
Duan
Lin
L
Li
Yan
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D003404:Creatinine / Q000097:blood; D005260:Female; D005922:Glomerulonephritis, IGA / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012044:Regression Analysis; D051437:Renal Insufficiency / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012189:Retrospective Studies; D016896:Treatment Outcome
D003404:Creatinine