Suzuki cross-coupling reactions of gamma-alkylidenebutenolides: application to the synthesis of vulpinic acid.
alpha-Hydroxy-gamma-alkylidenebutenolides were efficiently functionalized by Suzuki cross-coupling reactions via the corresponding enol triflates. The natural product vulpinic acid was prepared by this methodology.
Ahmed
Zafar
Z
Institut für Chemie und Biochemie der Ernst-Moritz-Arndt Universität Greifswald, Soldmannstr. 16, D-17487 Greifswald, Germany.
Langer
Peter
P
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D001897:Boronic Acids / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D010648:Phenylacetates / Q000138:chemical synthesis*
D001897:Boronic Acids; D005663:Furans; D010648:Phenylacetates; C077134:vulpinic acid; D010165:Palladium; C004511:butenolide; D015107:4-Butyrolactone