title: [Tumor redifferentiation in papillary thyroid carcinoma alter retinoic acid administration].
abstract: Male patient, 73 year old, with papillary thyroid carcinoma treated by surgery, 131I and L-Tyroxine, with bone metastasis, detected by bone scintigraphy and CT scan, which negative radioiodine uptake. In order to induce tumoral redifferentiation, retinoic acid (70 mg/day) was administered for three months before 131I treatment. A radioiodine scan performed after treatment showed uptake in some of the bone metastasis. Nine months later, and due to disease progression, a second induction with retinoic acid was performed before 131I treatment. The radioiodine scan performed after treatment showed greater uptake and higher number of bone lesions than the previous scan.
authors.affiliation: Departamento de Medicina Nuclear, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. mcamachom@hsp.santpau.es
authors.forename: V
authors.initials: V
authors.lastname: Camacho Martí
authors.forename: M
authors.initials: M
authors.lastname: Estorch Cabrera
authors.forename: E
authors.initials: E
authors.lastname: Mena González
authors.forename: J
authors.initials: J
authors.lastname: Fuertes Manuel
authors.forename: M A
authors.initials: MA
authors.lastname: Hernández Fructuoso
authors.forename: A
authors.initials: A
authors.lastname: Flotats Giralt
authors.forename: I
authors.initials: I
authors.lastname: Carrió Gasset
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000556:secondary; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014212:Tretinoin