title: Granulomatous lymphadenitis and splenitis associated with Monocillium indicum infection in a dog.
abstract: This report describes severe generalized granulomatous lymphadenitis and splenitis in a 5-year-old, spayed female, Rottweiler dog with anorexia and diarrhea. There was replacement or effacement of much of the parenchyma of the lymph nodes and spleen by sheets of macrophages, multinucleated giant cells, and myriad nonpigmented fungal organisms, most of which appeared to be intracellular. These organisms were very pleomorphic, including large chlamydospore-like cells, small round yeast-like cells, and septate hyphae. A fungus identified as Monocillium indicum was isolated from lymph node tissue. To the authors' knowledge, this is the first report of infection with Monocillium in either humans or other animals.
authors.affiliation: IDEXX Laboratories, Coorparoo DC, Queensland 4151, Australia.
authors.forename: John T
authors.initials: JT
authors.lastname: Mackie
authors.forename: Arvind A
authors.initials: AA
authors.lastname: Padhye
authors.forename: Reginald J
authors.initials: RJ
authors.lastname: Sutherland
authors.forename: Warwick A
authors.initials: WA
authors.lastname: Lamb
authors.forename: Stephen
authors.initials: S
authors.lastname: Davis
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000382:microbiology* / Q000473:pathology; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D008199:Lymphadenitis / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D003904:Mitosporic Fungi / Q000254:growth & development*; D009181:Mycoses / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D013158:Splenic Diseases / Q000150:complications / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*