Water and electrolyte absorption from hypotonic oral rehydration solution in rat small intestine and colon.
BACKGROUND
The authors evaluated and compared the efficacy of hypotonic oral rehydration solutions (ORS), isotonic ion solutions, and distilled water to elucidate the relation between net water absorption and osmolality, or between electrolyte absorption and their ion concentrations in rat small intestine and colon.


METHODS
Water and electrolyte absorption from two hypotonic ORS (Solita-T granules No. 2 [STG2]; sodium 60 mEq/L, osmolality 249 mOsm/L, Solita-T granules No. 3 [STG3]; sodium 35 mEq/L, osmolality 199 mOsm/L), two isotonic ion solutions (Aqualight [AL]; sodium 30 mEq/L, osmolality 290 mOsm/L, Pocarisweat [PS]; sodium 21 mEq/L, osmolality 300 mOsm/L), and distilled water, were evaluated by an in vivo perfusion technique with the small intestine and colon of anesthetized rats.


RESULTS
In the small intestine and colon, two hypotonic ORS significantly promoted net water absorption much greater than did two isotonic ion solutions (P < 0.05). Net sodium absorption from two hypotonic ORS was significantly greater than that from two isotonic ion solutions (P < 0.05). Sodium absorption from all solutions was greater in the colon than in the small intestine. Distilled water did not contribute to give net water absorption in the small intestine, but in the colon, it caused almost equivalent net water absorption to that by two hypotonic ORS. The largest amount of sodium secretion from the small intestine and colon was induced by distilled water.


CONCLUSIONS
These data indicate that low osmolality is a crucial factor to facilitate water absorption, and the electrolytes, sodium and chloride, can effectively be salvaged in the colon.
Nishinaka
Daisuke
D
Shimizu Research Center, Shimizu Pharmaceutical Co. Ltd, Shizuoka, Japan. daisuke_nishinaka@ajinomoto.com
Kishino
Fumiharu
F
Matsuura
Akihiro
A
D000818:Animals; D002712:Chlorides / Q000493:pharmacokinetics; D003106:Colon / Q000502:physiology; D005440:Fluid Therapy; D007038:Hypotonic Solutions; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000502:physiology; D007552:Isotonic Solutions; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000493:pharmacokinetics; D014882:Water-Electrolyte Balance
D002712:Chlorides; D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D012964:Sodium