title: Foundation and sites of action of antithrombotic agents.
abstract: Thromboembolic disorders are a major cause of morbidity and mortality. As knowledge of the complex interactions between the vessel wall, platelets and coagulation and fibrinolytic enzyme systems increases, new avenues for more effective and safer therapies become evident. In this review, we discuss mechanisms of hemostasis in relation to antithrombotic agents and results of clinical trials using these drugs.
authors.affiliation: Vascular Medicine Program, Los Angeles Orthopedic Hospital, and Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, CA, USA. vmarder@laoh.ucla.edu
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Marder
authors.forename: Michael H
authors.initials: MH
authors.lastname: Rosove
authors.forename: Dena M
authors.initials: DM
authors.lastname: Minning
mesh_terms: D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D005343:Fibrinolytic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D010975:Platelet Aggregation Inhibitors
chemical_list: D001779:Blood Coagulation Factors; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors