Biochemical effects of low level exposure to soman vapour.
The aim of this study was to demonstrate changes in acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, tyrosine aminotransferase activity (TAT) and plasma corticosterone level, neuroexcitability and behavior following 24 hours and 4 weeks of soman sublethal inhalation exposure at low level. AChE activity in erythrocytes and BuChE activity in plasma was decreased (dependent on the concentration of soman) 24 h and 4 weeks after the exposure. Similar decrease in AChE activity in different brain parts was observed. One of stressogenic parameters (TAT) was changed after 24 h exposure only. 4 weeks after the exposure, these parameters (corticosterone and TAT) were in the range of normal values. Behaviour of experimental animals was changed 24 h after the exposure persisting 4 weeks after the exposure as well as neuroexcitability.
Bajgar
J
J
Purkynĕ Military Medical Academy, Department of Toxicology, Hradec Králové, Czech Republic. bajgar@pmfhk.cz
Sevelová
L
L
Krejcová
G
G
Fusek
J
J
Vachek
J
J
Kassa
J
J
Herink
J
J
de Jong
L P A
LP
Benschop
H
H
D000110:Acetylcholinesterase / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000201:enzymology; D002091:Butyrylcholinesterase / Q000097:blood / Q000378:metabolism*; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D003964:Diaphragm / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006168:Guinea Pigs; D019570:Inhalation Exposure; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology; D012999:Soman / Q000633:toxicity*; D014444:Tyrosine Transaminase / Q000097:blood / Q000378:metabolism*
D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D012999:Soman; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases; D003345:Corticosterone