title: The regulatory software of cellular metabolism.
abstract: Understanding the regulation of metabolic pathways in the cell is like unraveling the 'software' that is running on the 'hardware' of the metabolic network. Transcriptional regulation of enzymes is an important component of this software. A recent systematic analysis of metabolic gene-expression data in Saccharomyces cerevisiae reveals a complex modular organization of co-expressed genes, which could increase our ability to understand and engineer cellular metabolic functions.
authors.affiliation: Department of Genetics, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA. dsegre@genetics.med.harvard.edu
authors.forename: Daniel
authors.initials: D
authors.lastname: Segrè
mesh_terms: D000465:Algorithms; D002384:Catalysis; D004798:Enzymes / Q000235:genetics / Q000378:metabolism; D020869:Gene Expression Profiling; D015971:Gene Expression Regulation, Enzymologic; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004798:Enzymes; D007527:Isoenzymes