title: Hepatocellular carcinoma in a patient with liver cirrhosis associated with negative serum HCV tests but positive liver tissue HCV RNA.
abstract: A 70-year-old woman was admitted to our hospital because of a liver tumor. Laboratory data revealed mild liver dysfunction. Neither serum anti-HCV antibody nor HCV-RNA was detected. Computed tomography revealed a tumor lesion measuring 2 cm in diameter within the liver. Histological examination of the tumor revealed moderately differentiated hepatocellular carcinoma while the non-tumorous liver tissue demonstrated liver cirrhosis. By the RT-PCR method, HCV-RNA was detected from the non-tumorous liver tissue. We herein report a very rare case of hepatocellular carcinoma in a patient with liver cirrhosis associated with negative serum HCV findings, but positive finding for liver tissue HCV RNA.
authors.affiliation: Third Department of Medicine, Fukuoka University School of Medicine, Fukuoka.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Esaki
authors.forename: Norihisa
authors.initials: N
authors.lastname: Suzuki
authors.forename: Keiji
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Kaoru
authors.initials: K
authors.lastname: Iwata
authors.forename: Makoto
authors.initials: M
authors.lastname: Irie
authors.forename: Akira
authors.initials: A
authors.lastname: Anan
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Nakane
authors.forename: Makoto
authors.initials: M
authors.lastname: Yoshikane
authors.forename: Shinya
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Syuichi
authors.initials: S
authors.lastname: Ueda
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sohda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Shotaro
authors.initials: S
authors.lastname: Sakisaka
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000821:virology*; D008103:Liver Cirrhosis / Q000150:complications / Q000821:virology*; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis*; D014057:Tomography, X-Ray Computed
chemical_list: D012367:RNA, Viral