Taurine protects against PMN dysfunction and death in urine.
The polymorphonuclear neutrophil (PMN) is the primary pro-inflammatory cell in the host response to bacterial infection and, as the first line of defence, is the principal cell responsible for the recognition, phagocytosis and killing of bacteria. PMN function is known to be defective in the urine. High osmolarity is physiologic in the urine and this hypertonic environment has been shown to compromise neutrophil function. In this study, PMN function was found to be suppressed in urine. This correlated with significant cell death, both by apoptosis and necrosis. The amino acid taurine down regulated PMN cell death and preserved function in the urine, suggesting taurine as a therapeutic option for urinary tract infection.
Condron
Claire M
CM
Department of Surgery, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. ccondron@rcsi.ie
Toomey
Deirdre M
DM
Casey
Rowan G
RG
Creagh
Tom
T
Bouchier-Hayes
David J
DJ
D000328:Adult; D017209:Apoptosis; D039481:CD11b Antigen / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects*; D015536:Down-Regulation / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009336:Necrosis; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D009994:Osmolar Concentration; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D016897:Respiratory Burst / Q000276:immunology; D013654:Taurine / Q000494:pharmacology*; D013997:Time Factors; D014556:Urine / Q000166:cytology* / Q000382:microbiology / Q000502:physiology
D039481:CD11b Antigen; D013654:Taurine