[Chemoradiation using 5-fluorouracil (5-FU) and nedaplatin (NDP) for gynecological malignancy--the relation between hemotoxicity and sequence of 5-FU and NDP].
We compared sequence-dependent schedules of 5-fluorouracil (5-FU) and nedaplatin (NDP) for hemotoxicity in genecological malignancy (GM). The safety of schedules using 5-FU before/after NDP combined radiotherapy in 8 patients with GM was evaluated. They received either 5-FU 700 mg/m2 i.v. continuous infusion on days (D) 1-4 + NDP 100 mg/m2 i.v. bolus on D1 (group A: 5 pts), or NDP on D4, 5-FU on D1-4 (group B: pts). In group A, 4 patients received a reduced dose of NDP because of less than 60 ml/min of creatinine clearance. In group A, WBC (2 pts), hemoglobin (3 pts), and platelet (1 pts) were grade 3 or higher. In group B, grade 3 or higher in hemotoxicity was not seen. A higher percentage of hemotoxicity was seen in group A compared with group B.
Itoh
Yoshiyuki
Y
Dept. of Radiology, Nagoya University Graduate School of Medicine.
Ishihara
Syunichi
S
Kumada
Satoshi
S
Takai
Katsufumi
K
Iwata
Masamitsu
M
Nakamura
Tatsuya
T
Kawase
Setsuko
S
Suzuki
Kohjiroh
K
Mori
Yoshine
Y
Hirasawa
Naoki
N
Satoh
Chiho
C
Fukushima
Hiromichi
H
Okuda
Takahito
T
Ota
Toyohiro
T
Yanagawa
Sigeo
S
Ishigaki
Takeo
T
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000532:radiotherapy; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects; D013921:Thrombocytopenia / Q000139:chemically induced
D006454:Hemoglobins; D009944:Organoplatinum Compounds; C053989:nedaplatin; D005472:Fluorouracil