title: Clinical value of protein S100 and melanoma-inhibitory activity (MIA) in malignant melanoma.
abstract: Serum protein S100 and melanoma-inhibitory protein (MIA) have been described as useful tumor markers for malignant melanoma. In this study, these two serum proteins were compared in 48 patients with melanoma at different stages of disease. Serum concentrations of S100 and MIA were measured by immunoradiometric and enzyme-linked immunosorbent assays, respectively. We found that the cut-off values were 17.4 ng/ml for MIA and 0.09 microg/l for S100. Five patients had stage I-II, 22 had stage III, and 21 had stage IV disease. Serum levels of two markers were elevated with metastatic disease (p < 0.05). Sensitivities of the MIA were found higher compared with S100 in patients with extensive (M1c) metastatic disease and with chemotherapy nonresponders (p > 0.05). We showed a trend for worsened outcome in patients with elevated MIA level in univariate analysis. MIA was found to be more sensitive and is a potential prognostic marker for patients with metastatic malignant melanoma in comparison with S100.
authors.affiliation: Institute of Oncology, University of Istanbul, Istanbul, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Tas
authors.forename: Vildan
authors.initials: V
authors.lastname: Yasasever
authors.forename: Derya
authors.initials: D
authors.lastname: Duranyildiz
authors.forename: Hakan
authors.initials: H
authors.lastname: Camlica
authors.forename: Zeki
authors.initials: Z
authors.lastname: Ustuner
authors.forename: Adnan
authors.initials: A
authors.lastname: Aydiner
authors.forename: Erkan
authors.initials: E
authors.lastname: Topuz
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D016326:Extracellular Matrix Proteins; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000188:drug therapy / Q000401:mortality / Q000556:secondary; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D009367:Neoplasm Staging; D009418:S100 Proteins / Q000097:blood*; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D016326:Extracellular Matrix Proteins; C090059:MIA protein, human; D009363:Neoplasm Proteins; D009418:S100 Proteins