title: Structural differences between paroxetine and femoxetine responsible for differential inhibition of Staphylococcus aureus efflux pumps.
abstract: In this study the chemical modification of paroxetine was employed to determine which structural differences between the paroxetine-like and femoxetine-like selective serotonin reuptake inhibitors is responsible for the differential potency of these agents in the inhibition of Staphylococcus aureus multidrug efflux pump systems.
authors.affiliation: Division of Medicinal and Natural Products Chemistry, The University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Wei
authors.forename: Glenn W
authors.initials: GW
authors.lastname: Kaatz
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kerns
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D001693:Biological Transport, Active / Q000187:drug effects; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D017374:Paroxetine / Q000737:chemistry* / Q000494:pharmacology; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D010880:Piperidines; D017374:Paroxetine; C010655:femoxetine