title: Vesicles as initial skin manifestation of disseminated fusariosis after non-myeloablative stem cell transplantation.
abstract: A 52-year-old man underwent non-myeloablative stem cell transplantation from his HLA identical sister for the treatment of mantle cell lymphoma. On day 0, he developed a high-grade fever, watery diarrhea and vesicles scattered on the skin. Well experienced dermatologists diagnosed these lesions as VZV reactivation. High dose antiviral agents were ineffective, and Fusarium solani was cultured from his stool and sputum. Systemic fusariosis progressed rapidly and he died of multiorgan failure on day 18. It is sometimes difficult to differentiate between viral and fungal blisters based on macroscopic examinations. We recommend early histopathological examination of the skin, when HSCT recipients develop vesicles.
authors.affiliation: Department of Hematology, Toranomon Hospital, 2-2-2 Toranomon, Minato-Ku, Tokyo 105-8470, Japan.
authors.forename: Tamae
authors.initials: T
authors.lastname: Hamaki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kami
authors.forename: Akiko
authors.initials: A
authors.lastname: Kishi
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusumi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwata
authors.forename: Shigesaburo
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: Junichi
authors.initials: J
authors.lastname: Ueyama
authors.forename: Shinichi
authors.initials: S
authors.lastname: Morinaga
authors.forename: Shuichi
authors.initials: S
authors.lastname: Taniguchi
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ohara
authors.forename: Yoshitomo
authors.initials: Y
authors.lastname: Muto
mesh_terms: D001768:Blister; D017809:Fatal Outcome; D016469:Fungemia; D005670:Fusarium / Q000302:isolation & purification*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000382:microbiology; D009181:Mycoses / Q000209:etiology* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology*; D019172:Transplantation Conditioning