Preimplantation genetic diagnosis in patients with male meiotic abnormalities.
Indications and candidates for preimplantation genetic diagnosis (PGD) have increased in recent years. This study evaluates whether IVF-intracytoplasmic sperm injection (ICSI) results could be improved by selecting embryos through PGD-AS (aneuploidy screening) in couples in whom the male partner presents meiotic abnormalities. Two hundred and fifty-six embryos were biopsied and 183 were suitable for analysis (73.2%). Ninety-two embryos showed normal chromosomal analysis (50.3% of the analysed embryos and 57.5% of the diagnosed embryos). Pregnancy, abortion and implantation rates were compared with 66 IVF-ICSI cycles performed in 44 patients with meiotic abnormalities without PGD (control group). No statistically significant differences in the pregnancy rate (52 versus 43.9%), implantation rate (32.1 versus 23.5%) and miscarriage rate (15.4 versus 10.3%) were observed between the groups. Although the embryos obtained from men with meiotic abnormalities showed a high frequency of chromosome abnormalities, no improvements in pregnancy and implantation rates were obtained after PGD-AS in the series analysed.
Aran
B
B
Departament d'Obstetricia i Ginecologia, Institut Universitari Dexeus, Passeig Bonanova 89-91, 08017 Barcelona, Spain. begara@dexeus.com
Veiga
A
A
Vidal
F
F
Parriego
M
M
Vendrell
J M
JM
Santaló
J
J
Egozcue
J
J
Barri
P N
PN
D000022:Abortion, Spontaneous / Q000453:epidemiology; D002869:Chromosome Aberrations; D010064:Embryo Implantation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D015994:Incidence; D008297:Male; D008540:Meiosis; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities* / Q000166:cytology*