[Regeneration of central nervous system: its concept and strategy].
It had been long believed that our adult mammalian central nervous system (CNS) does not regenerate after damage due to injuries or degenerative diseases, as Santiago Ramóny Cajal had indicated long time ago. Today, however, CNS came to be recognized as an important target of so called "regenerative medicine". We have been proposing that regeneration of CNS does include the following three concepts: i) re-growth of the damaged neuronal axons, ii) replenishment of lost neural (or neuronal) cells and iii) recovery of lost neural functions. Here, we would like to emphasize that to recapitulate normal neural development is an essential strategy for CNS-regeneration. In this review, we would like to take Parkinson's disease and spinal cord injury as examples to discuss actual strategy aiming for CNS-regeneration.
Okano
Hideyuki
H
Department of Physiology, Keio University School of Medicine.
Yoshizaki
Takahito
T
Okada
Seiji
S
D000818:Animals; D001369:Axons / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy; D044968:Regenerative Medicine; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000628:therapy; D033581:Stem Cell Transplantation