title: [Precurarization with rocuronium prevents fasciculations and biochemical changes after succinylcholine administration].
abstract: OBJECTIVE
  To determine the efficacy of rocuronium to prevent fasciculations and biochemical changes after succinylcholine administration.
  
  
  METHODS
  Prospective, randomized double-blind trial enrolling 60 ASA I-II patients scheduled for elective surgery under general anesthesia. The patients were assigned to 2 groups to receive either 0.06 mg x Kg(-1) of rocuronium or physiological saline solution 90 seconds before administration of 1.5 mg x Kg(-1) of succinylcholine. The incidence and severity of fasciculations and serum concentrations of potassium before anesthesia and 3, 5, and 20 minutes after succinylcholine administration were recorded. Other serum concentrations recorded were myoglobin, creatinine phosphokinase and lactate before anesthesia and 20 minutes after succinylcholine administration.
  
  
  RESULTS
  The increases in potassium levels at 3 and 5 minutes (0.3 +/- 0.3 and 0.2 +/- 0.4 mmol x L(-1)) and in myoglobin levels at 20 minutes (38.9 +/- 31.7 ng x mL(-1)) were attenuated by precurarization with rocuronium. The incidence of fasciculations was significantly lower (p<0.001) and their severity significantly less (p<0.001) in patients who received rocuronium before administration of succinylcholine.
  
  
  CONCLUSIONS
  Precurarization with rocuronium 90 seconds before succinylcholine administration reduces the incidence and severity of fasciculations and prevents increases in serum potassium and myoglobin concentrations.
authors.affiliation: Servicio de Anestesiología, Hospital Universitario Virgen de la Arrixaca, Murcia. joapal@ono.com
authors.forename: J
authors.initials: J
authors.lastname: Hernández-Palazón
authors.forename: J
authors.initials: J
authors.lastname: Noguera-Velasco
authors.forename: L F
authors.initials: LF
authors.lastname: Falcón-Araña
authors.forename: P
authors.initials: P
authors.lastname: Doménech-Asensi
authors.forename: S
authors.initials: S
authors.lastname: Burguillos-López
authors.forename: V
authors.initials: V
authors.lastname: Nuño de la Rosa-Carrillo
mesh_terms: D000293:Adolescent; D000328:Adult; D000732:Androstanols / Q000627:therapeutic use*; D004311:Double-Blind Method; D005207:Fasciculation / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use*; D011188:Potassium / Q000097:blood; D011446:Prospective Studies; D000077123:Rocuronium; D013390:Succinylcholine / Q000009:adverse effects*
chemical_list: D000732:Androstanols; D009211:Myoglobin; D003473:Neuromuscular Nondepolarizing Agents; D013390:Succinylcholine; D011188:Potassium; D000077123:Rocuronium