title: [Anaesthesia and amiodarone-associated hyperthyroidism].
abstract: Amiodarone can induce severe hyperthyroidism that justifies its withdrawal and initiation of antithyroid drugs. Impossibility to stop amiodarone, failure to control hyperthyroidism and unfavourable evolution can lead to thyroidectomy. Cardiac manifestations, persistence of hyperthyroidism and interactions between amiodarone and anaesthetic or haemodynamic drugs may contraindicate anaesthesia. We report nine consecutive cases of amiodarone-associated hyperthyroidism that prompted us to perform thyroidectomy under general anaesthesia. The features and anaesthetic data of patients were noted. The antithyroid medical treatment failed in all patients. After thyroidectomy, evolution was favourable in all nine cases, without any intra or postoperative complication, in spite of the extent of hyperthyroidism and the severity of the associated cardiac problems. Despite potential high risks, thyroidectomy for amiodarone-induced hyperthyroidism does not seem to increase morbidity or mortality and allows a quick return to euthyroidism and reintroduction of amiodarone.
authors.affiliation: Département d'anesthésie, HIA Percy, 101, avenue Henri-Barbusse, 92140 Clamart, France. merat.stephane@wanadoo.fr
authors.forename: S
authors.initials: S
authors.lastname: Mérat
authors.forename: E
authors.initials: E
authors.lastname: Perrier
authors.forename: E
authors.initials: E
authors.lastname: Lambert
authors.forename: B
authors.initials: B
authors.lastname: Lenoir
authors.forename: L
authors.initials: L
authors.lastname: Bonnevie
authors.forename: B
authors.initials: B
authors.lastname: Pats
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D000768:Anesthesia, General / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D013963:Thyroid Hormones / Q000097:blood; D013965:Thyroidectomy
chemical_list: D000889:Anti-Arrhythmia Agents; D013963:Thyroid Hormones; D000638:Amiodarone