title: Primary HIV type 1 infection.
abstract: Emerging evidence suggests that early events in human immunodeficiency virus type 1 (HIV-1) infection may play a critical role in determining disease progression. Although there is limited evidence on which to base medical decisions, the diagnosis and treatment of acute HIV-1 infection may have virologic, immunologic, and clinical benefits. In addition, rapid diagnosis of infection may prevent unknowing transmission of HIV-1 during a period of high-level viremia. We review the basic principles of primary HIV-1 infection, clinical and diagnostic markers of acute seroconversion, approaches to management, and new therapeutic strategies.
authors.affiliation: Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
authors.forename: Sigall
authors.initials: S
authors.lastname: Kassutto
authors.forename: Eric S
authors.initials: ES
authors.lastname: Rosenberg
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D018450:Disease Progression; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000635:transmission; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D014766:Viremia
chemical_list: D019380:Anti-HIV Agents