title: Presence of a human Hyaluronan binding protein 1 (HABP1) pseudogene-like sequence in Methanosarcina barkeri suggests its linkage in evolution.
abstract: The gene encoding Hyaluronan binding protein 1 (HABP1) and its homologs have been reported across eukaryotes, from yeast to human. We have reported the presence of processed pseudogenes in several human chromosomes, along with the location of the HABP1 gene on chromosome 17p12-p13. In this study, we report not only the presence of HABP1 pseudogene in other animal species, but also the presence of a homologous sequence in Methanosarcina barkeri, an ancient life form. This sequence has 44.8% homology to the human HABP1 cDNA and 45.3% homology with the HABP1 pseudogene in human chromosome 21. This sequence has a high G + C content (57%), characteristic of archaea, a family to which M. barkeri belongs. The presence of this HABP1 cDNA like fragment in M. barkeri might enable us to shed light on the evolution of the HABPl gene and whether it was present in a common ancestral organism before the lineages separated.
authors.affiliation: Biochemistry Laboratory, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Sengupta
authors.forename: Ilora
authors.initials: I
authors.lastname: Ghosh
authors.forename: Jaideep
authors.initials: J
authors.lastname: Mallick
authors.forename: Ashoke Ranjan
authors.initials: AR
authors.lastname: Thakur
authors.forename: Kasturi
authors.initials: K
authors.lastname: Datta
mesh_terms: D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins; D002891:Chromosomes, Human, Pair 21; D019143:Evolution, Molecular; D019766:Genes, Archaeal; D006801:Humans; D018960:Hyaluronan Receptors / Q000235:genetics*; D017021:Methanosarcina barkeri / Q000235:genetics*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D010802:Phylogeny; D011544:Pseudogenes / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: C087299:C1QBP protein, human; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D024101:Mitochondrial Proteins