[Immunogenecity of combined hepatitis A and B vaccine].
OBJECTIVE
To observe the immunogenicity of combined hepatitis A and B vaccine (HAB).


METHODS
The combined HAB vaccine was prepared and different concentrations of HAB were administered on mice in week 0, 4 and 24, and then we tested the antibodies to both hepatitis A virus and B virus. After the first injection, we tested the hepatitis A antigen-induced and hepatitis B surface antigen-induced stimulation indices in spleen monocyte as well as changes of CD4+ and CD8+ cell numbers.


RESULTS
The serum antibody positive rates were 100% in all three groups, and the antibody induced by HAB vaccine were earlier than by monovalent vaccine. The hepatitis A antibody and hepatitis B surface antibody titers after the combined vaccine inoculation were not significantly higher than those after the monovalent vaccine inoculation. On the other hand, after the first injection of the combined vaccine, the hepatitis A antigen-induced and hepatitis B surface antigen-induced stimulation indices in spleen monocyte were detected. The numbers of CD4+ and CD8+ cells increased.


CONCLUSIONS
HAB vaccine has reliable immunogenicity.
Shi
Li
L
Department of Genetics, Institute of Medical Biology, CAMS and PUMC, Kunming 650118, China.
Chu
Jia-you
JY
Sun
Ming-bo
MB
Huang
Xiao-qin
XQ
Yu
Jian-kun
JK
Li
Chang-you
CY
Sun
Hao
H
Yu
Liang
L
D000818:Animals; D016516:CD4-CD8 Ratio; D006506:Hepatitis A / Q000517:prevention & control; D035922:Hepatitis A Antibodies / Q000097:blood; D022362:Hepatitis A Vaccines / Q000276:immunology*; D006509:Hepatitis B / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D014611:Vaccination; D017778:Vaccines, Combined / Q000276:immunology
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D017778:Vaccines, Combined