title: [Immunohistochemical detection of PCNA and p53 protein in the premalignant lesions and squamous cell carcinomas of the oral mucosa]
abstract: PCNA and p53 protein expression were detected by immunohistochemical technique in 39 oral premalignant and malignant lesion;which included 11 oral mucosal leukoplakia(LK),9 oral lichen planus (LP),7 in situ carcinomas(ISC) and 12 squamous cell carcinomas(SCC);in order to investigate the significance of PCNA and p53 Protein overexpression in predicting malignant transformation.The results showed that the gradual strong expression of PCNA and mutated p53 protein positive signal from premalignant to malignant lesions.The remarkable correlation were found on PCNA expression between LK and ISC; on p53 protein expression between SCC I grade and SCC II grade and on PCNA and p53 protein expression between premalignant and malignant lesions.The results imply that expression of PCNA and mutated p53 protein may be as indicators for potential malignant development in benign lesions of oral mucosa premalignant.
authors.affiliation: Department of Oral Pathology, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University. Shanghai 200011,China.
authors.forename: X F
authors.initials: XF
authors.lastname: Huang
authors.forename: W G
authors.initials: WG
authors.lastname: Zhang
authors.forename: L J
authors.initials: LJ
authors.lastname: Song
authors.forename: H B
authors.initials: HB
authors.lastname: Fu