Aetiology of epilepsy in surgically treated patients in China.
The aim of this retrospective, multicenter clinical study was to evaluate the aetiology of epilepsy in surgically treated patients in China. The detailed clinical records of all intractable partial epilepsy (IPE) were reviewed in five tertiary referral centres from June 1991 to June 2000. 1650 patients (927 males, 723 females) were recruited. 41.4% had aetiological factors, including the histories of major brain trauma (20.9%), febrile seizure (6.5%), meningitis (5.4%), encephalitis (5.0%), prenatal distress (2.1%), birth trauma (0.8%) and family history of seizure (0.7%). The pathological lesions were divided into eight groups according to the nature of the lesion: scar (19.2%), vascular malformations (VM) (17.7%), hippocampal sclerosis (HS) (16.2%), tumours (15.0%), gliosis (12.1%), neuronal migration disorders (NMDs) (7.4%), intracranial infection (4.5%), and other lesions (7.9%). In conclusion, effective management of these aetiological factors and pathological lesions may be essential to deal with IPE. Scar, HS, VM, NMDs are the most likely consequences of antecedent morbid events.
Xiao
Bo
B
Institute of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, PR China. yanxia@public.cs.hn.cn
Huang
Zhi-Ling
ZL
Zhang
He
H
Liu
Yun-Sheng
YS
Yuan
Xian-Rui
XR
Zhang
Ning
N
Li
Jing-He
JH
Wang
Xiao-Yi
XY
Zhou
Dong
D
Liao
Wei-Ping
WP
Wang
Wei-Wei
WW
Sun
Bo-Min
BM
D001932:Brain Neoplasms / Q000145:classification / Q000150:complications* / Q000601:surgery; D020785:Central Nervous System Vascular Malformations / Q000150:complications; D002681:China / Q000453:epidemiology; D002921:Cicatrix; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000150:complications; D009017:Morbidity; D009483:Neuropsychological Tests; D009493:Neurosurgery / Q000379:methods*; D012189:Retrospective Studies; D012598:Sclerosis / Q000150:complications