In vitro maturation and fertilization of oocytes from an intact ovary of a surgically treated patient with endometrial carcinoma: case report.
Polycystic ovary syndrome (PCOS) with prolonged anovulation had resulted in endometrial carcinoma in a 43-year-old woman. Since she and her husband did not share common biological children, they requested fertility preservation. Due to the woman's age, high dose progesterone and postponing surgery were both considered inappropriate. We therefore proposed oocyte retrieval from the ovaries removed by staging laparotomy followed by in vitro maturation and ICSI. Surrogacy could then enable a future pregnancy. Fourteen of 17 (82%) retrieved oocytes matured in vitro. Following ICSI, eight embryos (two at the pronuclear stage and six cleaved) were cryopreserved. To the best of our knowledge, this is the first report of oocyte aspiration, maturation and fertilization from an ovary removed by laparotomy.
Revel
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Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, Jerusalem 91120, Israel. revel@md.huji.ac.il
Safran
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Benshushan
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Shushan
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Laufer
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Simon
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D000328:Adult; D002277:Carcinoma / Q000601:surgery; D002478:Cells, Cultured; D015925:Cryopreservation; D016889:Endometrial Neoplasms / Q000601:surgery; D005260:Female; D006801:Humans; D007813:Laparotomy; D009865:Oocytes; D009866:Oogenesis; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting