[Effect of novel natural hypolipidemic compounds on human immunodeficiency virus].
Target screening among microbial products resulted in isolation of hypolipidemic compounds tested for activity against HIV in culture of transferable lymphoblastoid cells MT-4. The majority of the compounds showed antiviral activity. The highest antiviral effect was observed when before exposure to the virus the cells were preincubated for 1 hour in the presence of the isolated compounds. The compounds showed no effect when added to the cell culture preliminarily infected by HIV.
Bibikova
M V
MV
National Research Centre of Antibiotics, Moscow, D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow.
Nosik
D N
DN
Lobych
O A
OA
Chmel'
Ia V
IaV
Katlinskiĭ
A V
AV
D019380:Anti-HIV Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*
D019380:Anti-HIV Agents; D000960:Hypolipidemic Agents