title: Variations in plasma free radicals with topical aescin + essential phospholipids gel in venous hypertension: new clinical data.
abstract: The aim of this study was the evaluation of the effects of Aescin + essential phospholipids (AEPL) gel on plasma free radicals (PFRs). In this study, ten patients with venous hypertension, no ulcerations or infections, venous microangiopathy, and varicose veins were treated with topical AEPL applied in a standard protocol. AEPL was applied for 2 weeks, three times daily at the same skin region (perimalleolar internal region at defined distance from the medial malleolus and from the anterior edge of the tibia). In subjects with venous hypertension, PFR values were higher than 420 Carr units. After treatment, the values of PRF decreased to almost normal as an effect of the massage with AEPL gel. The decrease in value was observed in all treatment subjects. A ranking system indicates that the AEPL preparation is active in all subjects who have venous microangiopathy. The decrease in PFR value was greater than 30% in all treatment subjects (p < 0.05). The decrease in PFR can be considered an important indication of an improvement in skin perfusion, which protects the skin from deterioration and eventually from venous ulcerations. The evaluation of PFR is an important new physiologic parameter that can be associated with other noninvasive tests to study the microcirculation and its evolution and improvement with systemic or topical medical treatment.
authors.affiliation: Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: I
authors.initials: I
authors.lastname: Ruffini
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: U
authors.initials: U
authors.lastname: Cornelli
authors.forename: M
authors.initials: M
authors.lastname: Corsi
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: E
authors.initials: E
authors.lastname: Ippolito
authors.forename: M
authors.initials: M
authors.lastname: Dugall
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D004338:Drug Combinations; D004928:Escin / Q000008:administration & dosage*; D005260:Female; D005609:Free Radicals / Q000097:blood*; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D014689:Venous Insufficiency / Q000097:blood / Q000188:drug therapy*; D014690:Venous Pressure
chemical_list: D004338:Drug Combinations; D005609:Free Radicals; D005782:Gels; D010713:Phosphatidylcholines; C011246:essential 303 forte; D004928:Escin