Effect of difructose anhydride III on calcium absorption in humans.
The effects of difructose anhydride III (DFAIII) on stimulating calcium absorption was investigated in humans. We studied changes in the time-course of characteristics urinary calcium excretion in 12 healthy men given 0.3, 1.0 or 3.0 g of DFAIII and 300 mg of calcium as calcium carbonate. In addition, urinary excretion and urine concentrations of creatinine and deoxypyridinoline were determined. Urine calcium excretion every 2 hours after the intake were higher over than that of the control subjects. The total amount of urinary calcium excretion for 10 hours was significantly greates in the subjects given 1.0 g or 3.0 g of DFAIII than that of the control subjects. However, there were no differences in the urine concentrations of creatinine and deoxypyridinoline between the subjects given DFAIII and the control subjects. These findings suggests that low dose of DFAIII had a stimulating effect on calcium absorption in humans.
Shigematsu
Norihiro
N
Food Research Division, Central Research Laboratory, FANCL Co, Ltd, Kanagawa-ken, Japan. noshigematsu@fancl.co.jp
Okuhara
Yasuhide
Y
Shiomi
Takuya
T
Tomita
Fusao
F
Hara
Hiroshi
H
D000596:Amino Acids / Q000652:urine; D002118:Calcium / Q000493:pharmacokinetics* / Q000652:urine; D003404:Creatinine / Q000652:urine; D004187:Disaccharides / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D015394:Molecular Structure
D000596:Amino Acids; D004187:Disaccharides; C087758:difructose anhydride III; C036020:deoxypyridinoline; D003404:Creatinine; D002118:Calcium