title: Deafferentation of the urinary bladder and implantation of a sacral anterior root stimulator (SARS) for treatment of the neurogenic bladder in paraplegic patients.
abstract: Since 25 years electrical stimulation has become an established and widely acknowledged therapy option. Today, FES is widely employed, e.g. for cardiostimulation, diaphragm stimulation, kinetotherapy, for treatment of tremor in Parkinson patients, and finally for bladder stimulation in patients with bladder voiding dysfunctions. Brindley was the first researcher who succeeded in stimulating the spinal nerves via implanted electrodes in an animal model. In the years 1978/79 Brindley implanted five paraplegic patients with so-called sacral anterior root stimulators; all of them were able to void under stimulation. This method of sacral anterior root stimulation (SARS) proved an alternative to frequent one-way catheterisation for patients with severe voiding dysfunctions, without achieving complete continence, however. The following study is to provide an overview over the latest insights in the context of implanting sacral anterior root stimulators; it discusses the preconditions required for such interventions and presents criteria to decide in which cases there is a contraindication for sacral deafferentation of the posterior roots. Moreover, it contrasts advantages and disadvantages of the intradural and extradural implantation methods and presents the currently available long-term follow-up results with SDAF and SARS for treatment of bladder voiding dysfunctions.
authors.affiliation: Dept. of Urology, University Hospital Schleswig-Holstein, Campus Kiel, Germany. cseif@urology.uni-kiel.de
authors.forename: C
authors.initials: C
authors.lastname: Seif
authors.forename: K P
authors.initials: KP
authors.lastname: Jünemann
authors.forename: P M
authors.initials: PM
authors.lastname: Braun
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology / Q000601:surgery*; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D019544:Equipment Failure Analysis; D006801:Humans; D010264:Paraplegia / Q000150:complications / Q000503:physiopathology / Q000534:rehabilitation* / Q000601:surgery; D010525:Peripheral Nerves / Q000503:physiopathology / Q000601:surgery; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods*; D012445:Sacrococcygeal Region / Q000503:physiopathology; D013126:Spinal Nerve Roots / Q000503:physiopathology*; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000294:innervation* / Q000601:surgery; D001750:Urinary Bladder, Neurogenic / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation* / Q000601:surgery*