Social stress-induced cortisol elevation acutely impairs social memory in humans.
Although stress is known to affect the memory process, little has been elucidated regarding its effect on social memory. In this study, 30 subjects' social memory (face-name association memory) performance was tested. Twenty subjects were exposed to social stress with a subsequent test of social memory, while the remaining ten subjects served as controls. Free cortisol was determined via saliva samples taken before and after the social stress exposure. Because stress hormones might have biphasic actions on neurons, we separated the subjects with cortisol elevations between high and low responders. The high responders had significantly impaired social memory. Furthermore, we observed a negative relation between social stress-induced cortisol elevation and social memory. These results indicate that social stress acutely impairs social memory.
Takahashi
Taiki
T
Department of Behavioral Science, Faculty of Letters, Hokkaido University, N.10, W.7, Kita-ku, Sapporo, 060-0810, Japan. ttakahashi@lynx.let.hokudai.ac.jp
Ikeda
Koki
K
Ishikawa
Miho
M
Tsukasaki
Takafumi
T
Nakama
Daisuke
D
Tanida
Shigehito
S
Kameda
Tatsuya
T
D000328:Adult; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000378:metabolism; D021641:Recognition, Psychology; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012919:Social Behavior; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology*
D006854:Hydrocortisone