IMP-1 and a novel metallo-beta-lactamase, VIM-6, in fluorescent pseudomonads isolated in Singapore.
Four carbapenem-resistant Pseudomonas spp. were isolated from patients in Singapore. One Pseudomonas putida isolate contained a bla(IMP-1) identical to that first described in Japan. The sequence of a variant bla(IMP-1) in Pseudomonas fluorescens contained four silent mutations compared with the original sequence. The remaining P. putida isolates contained bla(VIM-6), a novel VIM gene variant.
Koh
Tse Hsien
TH
Department of Pathology, Singapore General Hospital, 1 Hospital Dr., 168608 Singapore, Singapore. gptthk@sgh.com.sg
Wang
Grace Chee Yeng
GC
Sng
Li-Hwei
LH
D000595:Amino Acid Sequence; D015139:Blotting, Southern; D003227:Conjugation, Genetic; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D007525:Isoelectric Focusing; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics; D011552:Pseudomonas Infections / Q000382:microbiology; D011551:Pseudomonas fluorescens / Q000187:drug effects / Q000201:enzymology*; D016958:Pseudomonas putida / Q000187:drug effects / Q000201:enzymology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012846:Singapore; D001618:beta-Lactamases / Q000378:metabolism*
D004269:DNA, Bacterial; C409201:beta-lactamase IMP-1; D001618:beta-Lactamases