title: Porphyrin-DNA cross-linking agent hybrids: chemical synthesis and biological studies.
abstract: Three new porphyrin-DNA cross-linking conjugates 8, 9, and 10 have been synthesized. Their photoinduced DNA cleavage activity have been studied. The IC(50) values to THP-1 cells in the presence of porphyrin derivatives 8, 9, and 10 with photoirradiation were 5.6, 88.4, and 61.8 nM, respectively.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, China.
authors.forename: Hanping
authors.initials: H
authors.lastname: He
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.forename: Jingjing
authors.initials: J
authors.lastname: Xu
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaolian
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Cao
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D011166:Porphyrins; D004247:DNA