title: [Diffuse large B-cell lymphoma of the knee occurring 70 years after tuberculous arthritis].
abstract: A 72-year-old woman presented with a progressive swollen and painful left knee over a period of a month. The patient had a history of tuberculous arthritis of the left knee joint at the age of 1-2 years. Since then the knee showed a deformity and contraction. MRI scan demonstrated a soft tissue tumor measuring 7 x 8 x 6 cm in the front of the knee, a biopsy specimen taken from which revealed large B-cell lymphoma. The tumor cells showed a phenotype of CD3- CD5- CD10- CD20+ CD21- BCL2+, and surface immunoglobulin M-kappa. Since the lymphoma cells were found to be negative for Epstein-Barr virus encoded RNA by means of in situ hybridization, the DLBCL in this patient was thought to be caused by a different mechanism from pyothorax-associated lymphoma. The patient was treated with chemotherapy (CHOP) followed by radiotherapy, and obtained partial remission. There is no evidence of progression seven months after diagnosis.
authors.affiliation: Second Department of Internal Medicine, Mie University School of Medicine.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueno
authors.forename: Motoko
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Shoko
authors.initials: S
authors.lastname: Ogawa
authors.forename: Kanako
authors.initials: K
authors.lastname: Saito
authors.forename: Tetushi
authors.initials: T
authors.lastname: Takemitu
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Isao
authors.initials: I
authors.lastname: Tawara
authors.forename: Tohru
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shiku
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007719:Knee Joint; D016393:Lymphoma, B-Cell / Q000209:etiology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000209:etiology*; D013997:Time Factors; D014394:Tuberculosis, Osteoarticular / Q000150:complications*