title: Molecular signaling of somatostatin receptors.
abstract: Somatostatin is a neuropeptide family that is produced by neuroendocrine, inflammatory, and immune cells in response to different stimuli. Somatostatin acts as an endogenous inhibitory regulator of various cellular functions including secretions, motility, and proliferation. Its action is mediated by a family of G-protein-coupled receptors (called sst1-sst5) that are widely distributed in the brain and periphery. The five receptors bind the natural peptides with high affinity, but only sst2, sst5, and sst3 bind the short synthetic analogs used to treat acromegaly and neuroendocrine tumors. This review covers the current knowledge in somatostatin receptor biology and signaling.
authors.affiliation: INSERM U 531, IFR 31, CHU Rangueil, 31403 Toulouse Cedex 4, France.
authors.forename: Hicham
authors.initials: H
authors.lastname: Lahlou
authors.forename: Julie
authors.initials: J
authors.lastname: Guillermet
authors.forename: Marylis
authors.initials: M
authors.lastname: Hortala
authors.forename: Fabienne
authors.initials: F
authors.lastname: Vernejoul
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pyronnet
authors.forename: Corinne
authors.initials: C
authors.lastname: Bousquet
authors.forename: Christiane
authors.initials: C
authors.lastname: Susini
mesh_terms: D006801:Humans; D018358:Neuroendocrine Tumors / Q000503:physiopathology*; D017481:Receptors, Somatostatin / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017481:Receptors, Somatostatin