Carcinoid tumours of the larynx.
The larynx is a rare site of origin of neuroendocrine carcinomas. They can be divided into typical, atypical and small cell tumours on the basis of their histopathological differentiation. The tumour histology and prognosis correlate closely. The typical carcinoid tumours are well differentiated with a benign course. Conservative surgery for local disease is the treatment and is associated with good survival. The atypical carcinoid tumours are poorly differentiated with an aggressive course. Response to radiotherapy and chemotherapy is poor. The treatment of choice is adequate total excision of the lesion with neck dissection if there is clinical evidence of cervical lymphadenopathy and a careful follow-up so as to recognise and treat any metastatic spread. We present two cases with similar history and clinical findings-one typical and the other atypical-and discuss the relevant literature.
Bapat
Urmi
U
Department of Otorhinolaryngology and Head and Neck Surgery, Countess of Chester Hospital NHS Trust, Chester, UK. urmibapat@yahoo.com
Mackinnon
Neil A
NA
Spencer
Michael G
MG
D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008297:Male