Phosphatidylinositide 3-kinase/AKT in radiation responses.
Ionizing or ultraviolet radiation-induced cellular survival signaling pathways induce development of cancer and insensitivity of tumor cells to radiation therapy. Accumulating evidence suggests that the phosphatidylinositide 3-kinase (PI3K)/AKT signal pathway is a major contributor to radioresistance. In many cell types PI3K/AKT signaling is a key cytoprotective response downstream of the EGFR family receptors and mediated carcinogenesis. Cytokines, such as HGF, IGF-I, and IL-6 also protects cells against apoptosis induced by radiation through PI3K/AKT pathway. The mechanics by which PI3K/AKT signaling functions in radiation responses may include its regulation of mitochondrial proteins, transcription factors, translation machinery, and cell-cycle progression. In addition, cross-talk between the PI3K/AKT pathway and mitogen-activated protein kinases, protein kinase A, and protein kinase C signal pathway may also play an important role.
Zhan
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State key Laboratory of Experimental Hematology, Institute of Hematology, National Research Center of Stem Cell Engineering and Technology, Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin, China.
Han
Z C
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D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D002470:Cell Survival; D004789:Enzyme Activation / Q000528:radiation effects; D006801:Humans; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism* / Q000528:radiation effects; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism* / Q000528:radiation effects; D011518:Proto-Oncogene Proteins / Q000378:metabolism* / Q000528:radiation effects; D051057:Proto-Oncogene Proteins c-akt; D011827:Radiation; D011839:Radiation, Ionizing; D017382:Reactive Oxygen Species / Q000528:radiation effects; D015398:Signal Transduction / Q000528:radiation effects*; D014466:Ultraviolet Rays
D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D017382:Reactive Oxygen Species; C494918:AKT1 protein, human