Reperfusion assessment using myocardial contrast echocardiography in patients with ST-segment elevation acute myocardial infarction.
In this study, 29 patients underwent myocardial contrast echocardiography after presentation with ST-segment elevation acute myocardial infarction but before coronary angiography using a continuous infusion of microbubbles and real-time imaging with a low mechanical index. Patients with transmural perfusion defects at presentation subsequently had much larger infarctions (as measured by peak creatine phosphokinase-MB fraction) than did those with normal perfusion, indicating that myocardial contrast echocardiography may be a useful means to determine adequacy of reperfusion after thrombolytic therapy and in the selection of patients for adjunctive treatment, such as "rescue angioplasty."
Main
Michael L
ML
Mid America Heart Institute, Kansas City, Missouri 64111, USA. mmain@cc-pc.com
Kusnetzky
Lisa L
LL
Dillon
Drusilla
D
Daniel
William C
WC
D003287:Contrast Media; D003326:Coronary Circulation; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D004452:Echocardiography; D004562:Electrocardiography; D005240:Feasibility Studies; D005260:Female; D005466:Fluorocarbons; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D015425:Myocardial Reperfusion; D011446:Prospective Studies; D015912:Thrombolytic Therapy
D003287:Contrast Media; D005466:Fluorocarbons; D007527:Isoenzymes; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form; C042852:perflutren