Sickle cell cerebrovascular disease: usual and unusual findings on MR imaging and MR angiography.
This paper demonstrates usual and unusual findings on MR imaging (MRI) including fluid-attenuated inversion recovery (FLAIR), diffusion- and perfusion-weighted image and MR angiography (MRA) in 30 patients with sickle cell cerebrovascular disease. This paper also illustrates the underlying pathophysiology of sickle cell cerebrovascular disease by using the cases with usual and unusual MR findings, including long-time follow-up cases during transfusion therapy. MRI and MRA are useful in defining the basis for stroke and assessing the effects of chronic transfusion therapy.
Moritani
Toshio
T
Department of Radiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA. moritani2001@yahoo.com
Numaguchi
Yuji
Y
Lemer
Norma B
NB
Rozans
Martha K
MK
Robinson
Avin E
AE
Hiwatashi
Akio
A
Westesson
Per-Lennart
PL
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology; D001803:Blood Transfusion; D002539:Cerebral Arterial Diseases / Q000175:diagnosis; D002544:Cerebral Infarction / Q000175:diagnosis; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000175:diagnosis; D006801:Humans; D007089:Image Enhancement; D007223:Infant; D008137:Longitudinal Studies; D018810:Magnetic Resonance Angiography; D008297:Male; D009072:Moyamoya Disease / Q000175:diagnosis; D012640:Seizures / Q000175:diagnosis; D020521:Stroke / Q000175:diagnosis