title: [Expressions of c-fos in different brain regions after microinjection of 5-HT3 receptors agonist in hippocampus].
abstract: OBJECTIVE
  To explore the neuronal circuit and possible pathway related to the 5-HT3 receptors in hippocampus neuroimmunomodulation.
  
  
  METHODS
  SABC immunocytochemical staining was used to detect the c-fos expression.
  
  
  RESULTS
  A large number of FOS-positive neurons expression were found in the hippocampus and brain cortex at 1 hour after microinjection of 5-HT3 receptor agonist (I-PBG) in the hippocampus, but as time went on, the number of FOS positive-neurons gradually decrease. A small number of FOS positive-neurons were found only in the hypothalamus and gray matter around acqueduct of midbrain, respectively at 8 and 16 hs after injection of 1-PBG. The expression of c-fos induced by 1-PBG could be blocked by pre-microinjection of tropisetron.
  
  
  CONCLUSIONS
  Brain cortex-hippocampus hypothalamus-gray matter around acqueduct of midbrain forma neuronal network, which may be related to immunomodulation.
authors.affiliation: Jiangsu Province Center for Disease Prevention and Control, Nanjing 210009, China.
authors.forename: She-lan
authors.initials: SL
authors.lastname: Liu
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Zhang
authors.forename: De-yi
authors.initials: DY
authors.lastname: Xu
mesh_terms: D000818:Animals; D001645:Biguanides / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D005260:Female; D006624:Hippocampus / Q000187:drug effects*; D007150:Immunohistochemistry; D008297:Male; D008845:Microinjections; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
chemical_list: D001645:Biguanides; D016760:Proto-Oncogene Proteins c-fos; D017366:Serotonin Receptor Agonists; C008846:phenyl biguanide