What are the limits to the size of effective dynamic combinatorial libraries?
Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10(6) compounds. [structure: see text]
Corbett
Peter T
PT
Cambridge University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, U.K.
Otto
Sijbren
S
Sanders
Jeremy K M
JK