title: Management of brain metastases.
abstract: Solid tumour brain metastases are a frequent clinical dilemma for oncologists and general physicians. The sound management of brain metastases requires a multidisciplinary approach. In this review we discuss the diagnosis and management of brain metastases including the role of surgery, radiotherapy, and chemotherapy. The standard approaches of surgical excision and primary radiotherapy have evolved from randomised studies. However, controversies remain regarding post-surgery irradiation in the setting of a solitary metastasis and the role of palliative chemotherapy.
authors.affiliation: Department of Clinical Haematology and Medical Oncology, Royal Melbourne Hospital, Melbourne, Victoria, Australia. Lionel.Lim@petermac.org
authors.forename: L C
authors.initials: LC
authors.lastname: Lim
authors.forename: M A
authors.initials: MA
authors.lastname: Rosenthal
authors.forename: N
authors.initials: N
authors.lastname: Maartens
authors.forename: G
authors.initials: G
authors.lastname: Ryan
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods; D010166:Palliative Care / Q000379:methods; D011183:Postoperative Complications; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents