title: Coagulation factor V.
abstract: The coagulation cascade involves sequential enzymatic activations of serine protease zymogens that converge on the generation of thrombin. Factor V (FV) takes part in this process as a component of the prothrombinase complex. Besides its role as procoagulant factor, it is also involved in the physiologic anticoagulant pathway, by participating in the inactivation of activated factor VIII (FVIIIa). Given the dual role of FV, genetic defects in FV gene may result in opposite hemorrhagic or thrombotic phenotypes. This review focuses on the structure, function (procoagulant and anticoagulant), regulation (activation and inactivation) of FV as well as on the genetic defects associated with mutations in the FV gene.
authors.affiliation: Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti 3/5, 20133 Milan, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Duga
authors.forename: Rosanna
authors.initials: R
authors.lastname: Asselta
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Tenchini
mesh_terms: D001778:Blood Coagulation Disorders / Q000209:etiology; D005165:Factor V / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D005166:Factor V Deficiency; D006801:Humans
chemical_list: D005165:Factor V