title: Antitussive effects of the H1-receptor antagonist epinastine in patients with atopic cough (eosinophilic bronchitis).
abstract: Chronic cough is the only symptom of eosinophilic bronchitis (EB). There is considerable overlap between EB and atopic cough. To investigate the antitussive effects of a histamine H1-recetor antagonist, epinastine hydrochloride (epinastine, CAS 80012-43-7, Alesion; 20 mg/day, once daily), cough scores, pulmonary function, capsaicin cough threshold, and bronchial hyperresonsiveness (BHR) to methacholine (MCh) were evaluated before and after a 4-week treatment with epinastine in patients with EB. In the epinastine group, the cough scores were decreased significantly (18.3 +/- 6.1 in week 1, 17.4 +/- 6.7 in week 2, 15.1 +/- 6.2 in week 3, 14.0 +/- 4.8 in week 4) in comparison with the value of 35.3 +/- 8.7 in week -2). The cough threshold for capsaicin improved from 1.70 +/- 3.04 micromol/l to 12.7 +/- 17.6 micromol/l in the epinastine group (p < 0.05; baseline vs. week 4) The bronchial hyperresponsiveness to MCh (Dmin) did not change significantly either in the epinastine or the placebo groups. The morning and evening peak expiratory flow rate (PEFR, L/min) did not change from the baseline period in either the epinastine or the placebo groups. These results suggested that epinastine may be useful for treating patients with EB and that histamine H1-receptor is related to the pathophysiology of coughing in EB.
authors.affiliation: Department of Physical Therapy, Akita University School of Health Sciences, Akita, Japan. shioya@hos.akita-u.ac.jp
authors.forename: Takanobu
authors.initials: T
authors.lastname: Shioya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Satake
authors.forename: Manabu
authors.initials: M
authors.lastname: Kagaya
authors.forename: Masa-aki
authors.initials: MA
authors.lastname: Sano
authors.forename: Akiko
authors.initials: A
authors.lastname: Watanabe
authors.forename: Shin
authors.initials: S
authors.lastname: Fukui
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D000368:Aged; D000996:Antitussive Agents; D016535:Bronchial Hyperreactivity / Q000188:drug therapy; D001991:Bronchitis / Q000188:drug therapy* / Q000503:physiopathology; D002211:Capsaicin; D003371:Cough / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D003984:Dibenzazepines / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged; D018721:Muscarinic Agonists; D012129:Respiratory Function Tests
chemical_list: D000996:Antitussive Agents; D003984:Dibenzazepines; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D018721:Muscarinic Agonists; D016210:Methacholine Chloride; C053090:epinastine; D002211:Capsaicin