Oxazolidinone: search for highly potent antibacterial.
A number of substituted piperazinyl oxazolidinone derivatives have been synthesized and their antibacterial activities were evaluated by MIC determination. A systematic SAR was carried out to get highly potent oxazolidinone derivatives.
Lohray
Braj Bhushan
BB
Medicinal Chemistry Department, Zydus Research Centre, Cadila Healthcare Ltd, Sarkhej-Bavla N. H.8A, Moraiya, Ahmedabad 382210, India. braj.lohray@zyduscadila.com
Lohray
Vidya Bhushan
VB
Srivastava
Brijesh Kumar
BK
Gupta
Sunil
S
Solanki
Manish
M
Kapadnis
Prashant
P
Takale
Vijay
V
Pandya
Purvi
P
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D023303:Oxazolidinones