title: Prognostic significance of soluble adhesion molecules in Hodgkin's disease.
abstract: BACKGROUND
  Cell adhesion may play a pivotal role in the development, progression and metastasis of solid malignancies. We evaluated the serum concentration of four adhesion molecules and their prognostic significance in patients with Hodgkin's Disease (HD).
  
  
  METHODS
  Serum samples from 20 HD patients were collected at diagnosis, after 3 cycles of chemotherapy and at completion of treatment and compared with a control group of 29 apparently healthy subjects. Soluble forms of E-Selectin (sE-Selectin), ICAM-1 (sICAM-1), VCAM-1 (sVCAM-1) and E-Cadherin (sE-Cad) were measured by standard ELISA assays.
  
  
  RESULTS
  Significantly increased serum levels of sICAM-1 and sE-Selectin were determined in HD patients at diagnosis compared to controls (p<0.0001), while sVCAM-1 at diagnosis correlated significantly with both sICAM-1 and sE-Selectin levels (r=0.5, p=0.03). Chemotherapy resulted in a significant decrease of sICAM-1 and sE-Selectin levels (p=0.02 and p=0.002, respectively).
  
  
  CONCLUSIONS
  Serum levels of ICAM-1 and E-Selectin in newly diagnosed HD patients were found significantly increased, suggesting a possible involvement of these two molecules in the pathogenesis of the disease. Their rapid decrease following chemotherapy was found to be an independent predictor of response to treatment.
authors.affiliation: Oncology/Haematology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece. knsyrigos@usa.net
authors.forename: K N
authors.initials: KN
authors.lastname: Syrigos
authors.forename: E
authors.initials: E
authors.lastname: Salgami
authors.forename: A J
authors.initials: AJ
authors.lastname: Karayiannakis
authors.forename: N
authors.initials: N
authors.lastname: Katirtzoglou
authors.forename: E
authors.initials: E
authors.lastname: Sekara
authors.forename: P
authors.initials: P
authors.lastname: Roussou
mesh_terms: D000328:Adult; D000368:Aged; D015820:Cadherins / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin / Q000097:blood; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012995:Solubility; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
chemical_list: D015820:Cadherins; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1