title: Adenovirus types 5 and 35 seroprevalence in AIDS risk groups supports type 35 as a vaccine vector.
abstract: The seroprevalence of adenovirus types 5 (Ad5) and 35 (Ad35) was investigated in patients at risk of AIDS. The seroprevalence of Ad5 was higher than Ad35 in HIV-infected patients from The Netherlands (60% versus 7%) and sub-Saharan Africa (90% versus 20%). The seroprevalence was similar among HIV-infected and uninfected individuals, and remained constant during progression to AIDS. Ad35 is less prone to neutralization than Ad5, encouraging the further development of Ad35 for vaccination against HIV.
authors.affiliation: Crucell Holland BV, Leiden, The Netherlands.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kostense
authors.forename: Wouter
authors.initials: W
authors.lastname: Koudstaal
authors.forename: Mieke
authors.initials: M
authors.lastname: Sprangers
authors.forename: Gerrit Jan
authors.initials: GJ
authors.lastname: Weverling
authors.forename: Germaine
authors.initials: G
authors.lastname: Penders
authors.forename: Niels
authors.initials: N
authors.lastname: Helmus
authors.forename: Ronald
authors.initials: R
authors.lastname: Vogels
authors.forename: Margreet
authors.initials: M
authors.lastname: Bakker
authors.forename: Ben
authors.initials: B
authors.lastname: Berkhout
authors.forename: Menzo
authors.initials: M
authors.lastname: Havenga
authors.forename: Jaap
authors.initials: J
authors.lastname: Goudsmit
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology / Q000821:virology*; D000260:Adenoviruses, Human / Q000276:immunology / Q000302:isolation & purification*; D017954:Africa South of the Sahara / Q000453:epidemiology; D000914:Antibodies, Viral / Q000097:blood*; D005822:Genetic Vectors; D006801:Humans; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral