title: Anticonvulsants and the relief of chronic pain: pregabalin and gabapentin as alpha(2)delta ligands at voltage-gated calcium channels.
abstract: Anticonvulsants that act as ligands at alpha(2)delta subunits of voltage-gated calcium channels are proving to be novel treatments for chronic pain.
authors.affiliation: Neuroscience Education Institute in Carlsbad, California 92009, USA.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Stahl
mesh_terms: D000085:Acetates / Q000494:pharmacology* / Q000627:therapeutic use; D000588:Amines; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D015220:Calcium Channels / Q000187:drug effects* / Q000502:physiology; D002908:Chronic Disease; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D006801:Humans; D008024:Ligands; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D010147:Pain Measurement / Q000187:drug effects; D000069583:Pregabalin; D013001:Somatoform Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; C425903:CACNA2D1 protein, human; D015220:Calcium Channels; D003509:Cyclohexanecarboxylic Acids; D008024:Ligands; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin