title: Phylogenetic analysis of wild-type 1 polioviruses isolated during the final period of transmission in Turkey.
abstract: The last poliomyelitis case associated with a wild poliovirus in Turkey occurred in November 1998. This was the last known case of paralytic poliomyelitis caused by indigenous wild poliovirus in the World Health Organization's European Region. This study investigated the genetic relationships of wild-type 1 polioviruses at the latest period of transmission. A phylogenetic tree was constructed on the basis of the VP1/2A sequence from 14 wild-type 1 polioviruses isolated from Turkey in 1994-1998, along with those from other areas of the world. The Turkey isolates in the latest period of transmission were closely related to each other, forming a cluster distinct from other strains. The results showed that these viruses had been spreading indigenously in the eastern and south-eastern parts of Turkey, and ceased transmission there during 1998. This finding serves as a reference for future poliovirus surveillance both in Turkey and worldwide.
authors.affiliation: Virology Department, Refik Saydam National Hygiene Center, Cemal Gursel Cad 16, Sihhiye 06100, Ankara, Turkey.
authors.forename: Etem
authors.initials: E
authors.lastname: Özkaya
authors.affiliation: Research and Development Department, Mitsubishi Kagaku Bio-Clinical Laboratories Inc., Shimura 3-30-1, Itabashi-ku, Tokyo 174-8555, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ishiko
authors.affiliation: Research and Development Department, Mitsubishi Kagaku Bio-Clinical Laboratories Inc., Shimura 3-30-1, Itabashi-ku, Tokyo 174-8555, Japan.
authors.forename: Rika
authors.initials: R
authors.lastname: Miura
authors.affiliation: Research and Development Department, Mitsubishi Kagaku Bio-Clinical Laboratories Inc., Shimura 3-30-1, Itabashi-ku, Tokyo 174-8555, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shimada
authors.affiliation: Virology Department, Refik Saydam National Hygiene Center, Cemal Gursel Cad 16, Sihhiye 06100, Ankara, Turkey.
authors.forename: Iffet
authors.initials: I
authors.lastname: Alaeddinoglu
authors.affiliation: Virology Department, Refik Saydam National Hygiene Center, Cemal Gursel Cad 16, Sihhiye 06100, Ankara, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Artuk
authors.affiliation: Japan International Cooperation Agency, Yoyogi 2-1-1, Shibuya-ku, Tokyo 151-8558, Japan.
authors.forename: Kikuko
authors.initials: K
authors.lastname: Miyamura
authors.affiliation: Research and Development Department, Mitsubishi Kagaku Bio-Clinical Laboratories Inc., Shimura 3-30-1, Itabashi-ku, Tokyo 174-8555, Japan.
authors.forename: Shudo
authors.initials: S
authors.lastname: Yamazaki
mesh_terms: D036022:Capsid Proteins / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000235:genetics; D006801:Humans; D010802:Phylogeny; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology; D017955:Poliovirus / Q000145:classification* / Q000235:genetics; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology; D014764:Viral Proteins
chemical_list: D036022:Capsid Proteins; D014764:Viral Proteins; D003546:Cysteine Endopeptidases; C057400:picornain 2A, Picornavirus