title: Functional evaluation of lung by Xe-133 lung ventilation scintigraphy before and after lung volume reduction surgery (LVRS) in patients with pulmonary emphysema.
abstract: We evaluated the respiratory functions of patients with pulmonary emphysema who underwent lung volume reduction surgery (LVRS) by the mean transit time (MTT) with Xe-133 lung ventilation scintigraphy, forced expiration volume in 1 sec (FEV1.0), residual volume (RV), distance walked in 6 min (6-min walk), and the Hugh-Jones classification (H-J classification) before and after LVRS. In 69 patients with pulmonary emphysema (62 men, 7 women; age range, 47-75 years; mean age, 65.4 years +/- 6.1, preoperative H-J classification, III (two were II)-V) who underwent LVRS, all preoperative and postoperative parameters (MTT 3 weeks after LVRS and the others 3 months after LVRS) were judged statistically by the Wilcoxon signed-ranks test and Odds ratio. Every postoperative parameter was improved with a significant difference (P < 0.05) compared to preoperative parameters. MTT at 3 weeks after LVRS was not associated with %FEV1.0 and the H-J classification at 3 months after LVRS, but was associated with RV and a 6-min walk at 3 months after LVRS. MTT was useful for the clinical evalution of aerobic capability after LVRS.
authors.affiliation: Department of Radiology, Faculty of Health Sciences, Okayama University Medical School, Okayama 700-8558, Japan. kurose@vesta.dti.ne.jp
authors.forename: Taichi
authors.initials: T
authors.lastname: Kurose
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okumura
authors.forename: Shuhei
authors.initials: S
authors.lastname: Sato
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Shiro
authors.initials: S
authors.lastname: Akaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Susumu
authors.initials: S
authors.lastname: Kanazawa
authors.forename: Akio
authors.initials: A
authors.lastname: Ando
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Shimizu
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hiraki
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000601:surgery*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D011656:Pulmonary Emphysema / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests; D016896:Treatment Outcome; D016138:Walking; D014980:Xenon Radioisotopes / Q000378:metabolism*
chemical_list: D014980:Xenon Radioisotopes