title: Autoimmune thyroid disease in anti-Ro/SS-A-positive children with annular erythema: report of two cases.
abstract: Anti-Ro/SS-A-associated recurrent annular erythema is a rare disorder, and represents a cutaneous manifestation of primary Sjögren's syndrome (SS). We report two childhood cases complicated with autoimmune thyroid disease, one with Graves' disease and the other with autoimmune thyroiditis. Both children were positive for anti-Ro/SS-A and anti-La/SS-B antibodies. One patient was lacking clinical SS with objective evidence of salivary gland involvement, while the other was diagnosed with primary SS. Our observation suggests that autoimmune thyroid disease in the subset of anti-Ro/SS-A-positive children with annular erythema might occur with similar frequency to that in adult primary SS.
authors.affiliation: Department of Dermatology, Nara Medical University, Kashihara City, Nara 634-8522, Japan. sachikom@naramedu-ac-jp
authors.forename: S
authors.initials: S
authors.lastname: Miyagawa
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Ishihara
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Taira
authors.forename: A
authors.initials: A
authors.lastname: Yoshioka
authors.forename: H
authors.initials: H
authors.lastname: Asada
mesh_terms: D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000097:blood*; D001324:Autoantigens; D002648:Child; D004890:Erythema / Q000276:immunology* / Q000473:pathology; D005148:Facial Dermatoses / Q000276:immunology; D005260:Female; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000276:immunology; D012859:Sjogren's Syndrome / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies