Detection of functional platelet-activating factor receptors on leukemic B cells of chronic lymphocytic leukemic patients.
Although platelet-activating factor receptors (PAF-R) are reported on normal B cells, few results are available concerning leukemic ones. We demonstrated functional PAF-R on cell and nuclear surfaces of leukemic B cells of chronic lymphocytic leukemic (CLL) patients. Analysis of 102 patients revealed dramatic differences for their membrane PAF-R expression, a result that might be related to their plasma IL-4 levels. In the light of the potent immunoregulatory role of PAF on B cell physiology, it is suggested that the presence or absence of PAF-R on leukemic B cells may profoundly affect their in vivo behavior.
Denizot
Y
Y
UMR CNRS 6101, Laboratoire d'Hématologie and Service d'Hématologie Clinique et de Thérapie Cellulaire, CHU Dupuytren, Limoges, France. yves.denizot@unilim.fr
Donnard
M
M
Guglielmi
L
L
Faucher
J L
JL
Jaccard
A
A
Bordessoule
D
D
Trimoreau
F
F
D000368:Aged; D001402:B-Lymphocytes / Q000737:chemistry* / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D002462:Cell Membrane / Q000737:chemistry; D005260:Female; D006801:Humans; D015847:Interleukin-4 / Q000097:blood; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D009685:Nuclear Envelope / Q000737:chemistry; D010980:Platelet Membrane Glycoproteins / Q000032:analysis*; D043562:Receptors, G-Protein-Coupled / Q000032:analysis*; D016212:Transforming Growth Factor beta / Q000097:blood
D010980:Platelet Membrane Glycoproteins; D043562:Receptors, G-Protein-Coupled; D016212:Transforming Growth Factor beta; C039351:platelet activating factor receptor; D015847:Interleukin-4