Prostate cancer and body size at different ages: an Italian multicentre case-control study.
We investigated the influence of anthropometric measures at diagnosis and at different ages on prostate cancer risk using an Italian multicentre case-control study conducted between 1991 and 2002 of 1294 histologically confirmed cases and 1451 controls admitted to the same network of hospitals for acute non-neoplastic conditions. Height, weight, body mass index (BMI), waist-to-hip ratio, lean body mass 1 year before diagnosis/interview were not significantly associated with risk. However, a positive association with high BMI at age 30 years was found (odds ratio=1.2 for BMI> or =24.7 vs <22.7) and: for less differentiated prostate cancer, with BMI 1 year before diagnosis/interview. This study supports possible relationships between high body mass in young adulthood, and a tendency to high weight throughout adult life, and the risk of prostate cancer.
Dal Maso
L
L
Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Via Pedemontana Occ.le 12, 33081 Aviano (PN), Italy. epidemiology@cro.it
Zucchetto
A
A
La Vecchia
C
C
Montella
M
M
Conti
E
E
Canzonieri
V
V
Talamini
R
R
Tavani
A
A
Negri
E
E
Garbeglio
A
A
Franceschi
S
S
D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000209:etiology* / Q000473:pathology; D012307:Risk Factors