title: Factors associated with severe impact of lipodystrophy on the quality of life of patients infected with HIV-1.
abstract: A standardized questionnaire was used to assess the impact of lipodystrophy (LD) on quality of life (QoL). Eighty-four consecutive asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected outpatients with clinical LD completed a modified version of the Dermatology Life Quality Index (DLQI) survey to measure the impact of body fat changes on their QoL. Body changes influenced dressing for 55 patients (65%), produced feelings of shame for 41 (49%), and disrupted sexual life for 23 (27%). There was a greater impact on the DLQI due to body changes among women, injection drug users, patients with abdominal or breast lipoaccumulation, and patients with a high number of non-LD side effects. Multivariate proportional odds model analysis showed that the severity of non-LD-associated side effects and the presence of breast lipoaccumulation were associated with impaired psychosocial functioning. Specific characteristics of patients, antiretroviral-based side effects, and breast lipoaccumulation exert a greater impact on QoL in HIV-1-infected patients with LD.
authors.affiliation: Clinical Institute of Psychiatry and Psychology, Hospital Clínic Universitari de Barcelona, 08036 Barcelona, Spain. jblanch@clinic.ub.es
authors.forename: Jordi
authors.initials: J
authors.lastname: Blanch
authors.forename: Araceli
authors.initials: A
authors.lastname: Rousaud
authors.forename: Esteban
authors.initials: E
authors.lastname: Martinez
authors.forename: Elisa
authors.initials: E
authors.lastname: De Lazzari
authors.forename: Ana
authors.initials: A
authors.lastname: Milinkovic
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Peri
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Blanco
authors.forename: Jesús
authors.initials: J
authors.lastname: Jaen
authors.forename: Victor
authors.initials: V
authors.lastname: Navarro
authors.forename: Guillem
authors.initials: G
authors.lastname: Massana
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Gatell
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D015497:HIV-1; D006801:Humans; D008060:Lipodystrophy / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D015999:Multivariate Analysis; D011788:Quality of Life