title: Synthesis and antibacterial activity of a novel class of 4'-substituted 16-membered ring macrolides derived from tylosin.
abstract: Novel 4'-substituted 16-membered ring macrolides were synthesized by the cleavage of the mycarose sugar of tylosin and subsequent modification of 4'-hydroxyl group. This new class of macrolide antibiotics exhibited potent activity against some key erythromycin-resistant pathogens.
authors.affiliation: Enanta Pharmaceuticals, Inc., 500 Arsenal Street, Watertown, MA 02472, USA.
authors.forename: Ly T
authors.initials: LT
authors.lastname: Phan
authors.forename: Tianying
authors.initials: T
authors.lastname: Jian
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.forename: Yao-Ling
authors.initials: YL
authors.lastname: Qiu
authors.forename: Zhaolin
authors.initials: Z
authors.lastname: Wang
authors.forename: Theresa
authors.initials: T
authors.lastname: Beach
authors.forename: Alex
authors.initials: A
authors.lastname: Polemeropoulos
authors.forename: Yat Sun
authors.initials: YS
authors.lastname: Or
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D006193:Haemophilus influenzae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects; D015645:Tylosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D015645:Tylosin