Oxidative damage and schizophrenia: the potential benefit by atypical antipsychotics.
There is evidence to suggest the derangement of the oxidant and antioxidant defense system in schizophrenia. The present study examined the effect of atypical antipsychotics on lipid peroxidation, superoxide dismutase (SOD) and ascorbic acid. For this purpose, a prospective, open-label, 8-week study design was utilized. Serum SOD, serum malondialdehyde (MDA) and plasma ascorbic acid were estimated. Schizophrenic patients (n = 48) were compared with age- and sex-matched healthy volunteers (n = 40). There was a significant increase in serum SOD, serum MDA and a decrease in plasma ascorbic acid in schizophrenic patients as compared to control subjects. The trend altered significantly after the treatment with atypical antipsychotics. The results of the Brief Psychiatric Rating Scale for schizophrenia also improved with the treatment. The findings indicate an involvement of free radicals in schizophrenia and its modification by treatment with atypical antipsychotics. This study can also be used as a predictor of drug response by atypical antipsychotics in schizophrenia.
Dakhale
Ganesh
G
Department of Pharmacology, Government Medical College, Nagpur, Maharashtra, India. gndakhle@rediffmail.com
Khanzode
Suchet
S
Khanzode
Shruti
S
Saoji
Anand
A
Khobragade
Linesh
L
Turankar
Avinash
A
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000097:blood*; D010054:Brief Psychiatric Rating Scale / Q000706:statistics & numerical data; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood*
D014150:Antipsychotic Agents; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001205:Ascorbic Acid