Use of acid fluorides increases the scope of the reductive acylation of esters.
The use of acyl fluorides in the Rychnovsky reductive acylation of esters allows a variety of esters to be converted to their corresponding alpha-acyloxy ethers in good to excellent yields, without the need to sacrifice an extra equiv of carboxylic acid functionality. [structure: see text]
Zhang
Yongda
Y
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Rovis
Tomislav
T
D000143:Acids / Q000737:chemistry*; D000215:Acylation; D004952:Esters / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000143:Acids; D004952:Esters; D005459:Fluorides