title: Severe granulomatous inflammatory response induced by injection of polyacrylamide gel into the facial tissue.
abstract: Facial soft tissue augmentation has been performed using different materials. We describe a woman who received polyacrylamide gel injections for cosmetic reasons and developed a severe granulomatous inflammation paranasally. Because the patient did not mention the cosmetic intervention, the diagnosis of polyacrylamide gel-induced granuloma was complicated. The distinctive histopathological findings led to the correct diagnosis despite sparse clinical information. Since complete surgical excision was not feasible, she was treated with repeated multiple local injections of triamcinolone acetonide. Polyacrylamide gel may have favorable properties for facial tissue augmentation, but a severe granulomatous inflammatory response induced by injection of polyacrylamide gel may occur. Before treatment with polyacrylamide gel injection this complication should be disclosed to the patient.
authors.affiliation: Departments of Otolaryngology - Head and Neck Surgery, Vrije Universiteit Medical Center/ACTA, Amsterdam. r.bree@vumc.nl
authors.forename: Remco
authors.initials: R
authors.lastname: de Bree
authors.forename: M J René
authors.initials: MJ
authors.lastname: Middelweerd
authors.forename: Isaäc
authors.initials: I
authors.lastname: van der Waal
mesh_terms: D000180:Acrylic Resins / Q000008:administration & dosage / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D005145:Face; D005260:Female; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007279:Injections, Subcutaneous; D008875:Middle Aged; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D000180:Acrylic Resins; D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; C016680:polyacrylamide gels; D014222:Triamcinolone Acetonide