title: Application of statistical 'design of experiments' methods in drug discovery.
abstract: The use of 'design of experiments' (DoE) is a revolutionary approach to optimisation and screening of experimental parameters. Simple experimental designs and statistical tools for data analysis can provide much information about the system under investigation after only a few experiments. Such information can be key in decision-making for further experiments and can enable the development of robust and reliable protocols for chemical synthesis, analytical methods or biological assays. Coupling of design of experiments with modern high-throughput automation systems has the potential to maximise the capabilities of these systems and give increased productivity for many drug discovery applications.
authors.affiliation: Evotec OAI, 151 Milton Park, Abingdon, Oxfordshire, UK, OX14 4SD. heather.tye@evotecoai.com
authors.forename: Heather
authors.initials: H
authors.lastname: Tye
mesh_terms: D001681:Biological Assay / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D008872:Microwaves; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D012107:Research Design; D013223:Statistics as Topic; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations