title: [Renal transplantation surgery is closely linked with treatment for bilateral synchronous renal cell carcinomas or renal tumors in solitary kidney].
abstract: We describe 4 cases of bilateral synchronous renal cell carcinoma and 3 of renal tumor in solitary kidney. One of the 3 patients with renal tumor in solitary kidney underwent partial nephrectomy. The remaining 2 patients, who had renal tumors greater than 7 cm located in the central region, underwent extracorporeal surgery. Development of acute renal failure and renal bleeding after ex vivo surgery occurred in 1 female patient, who required autograftectomy and temporary dialysis but subsequently underwent a re-operative procedure for renal transplantation with a kidney donated by her 82-year-old mother. Two of the 4 patients underwent partial nephrectomy, 1 with multiple bone and lung metastases had all carcinoma foci extracted at the second stage and was administered UFT and IFN alpha, and the remaining 2 patients, who both had hereditary renal cell carcinoma with multiple tumors in both kidneys, received living-donor related renal transplantation soon after bilateral nephrectomy. In the period of follow-up, ranging from 2 to 14 years, all the patients are well with no relapse and have good renal function. These results indicate kidney transplant procedures may have been linked with the options of bilateral synchronous renal cell carcinoma and renal tumor in solitary kidney.
authors.affiliation: Dept. of Urology, Kure Kyosai Hospital.
authors.forename: Naoki
authors.initials: N
authors.lastname: Mitsuhata
authors.forename: Seiichi
authors.initials: S
authors.lastname: Ito
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000601:surgery*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D007668:Kidney / Q000002:abnormalities* / Q000601:surgery; D007680:Kidney Neoplasms / Q000601:surgery*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D009392:Nephrectomy / Q000379:methods; D011182:Postoperative Care; D005641:Tegafur / Q000008:administration & dosage; D014182:Transplantation, Autologous; D014498:Uracil / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; D016898:Interferon-alpha; C096910:UFT(R) drug; D005641:Tegafur; D014498:Uracil