Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase-thymidylate synthase.
Belperron
Alexia A
AA
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Fox
Barbara A
BA
O'Neil
Robert H
RH
Peaslee
Kimberly A W
KA
Horii
Toshihiro
T
Anderson
Amy C
AC
Bzik
David J
DJ
D000595:Amino Acid Sequence; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology; D015153:Blotting, Western; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics*; D016254:Mutagenesis, Insertional; D009154:Mutation; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011739:Pyrimethamine / Q000494:pharmacology; D015183:Restriction Mapping; D016415:Sequence Alignment; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000235:genetics*; D013940:Thymidylate Synthase / Q000737:chemistry / Q000235:genetics*; D014122:Toxoplasma / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D014162:Transfection
D000981:Antiprotozoal Agents; D009097:Multienzyme Complexes; C056930:thymidylate synthase-dihydrofolate reductase; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D011739:Pyrimethamine