[Morphological evidence on participating in adhesive function of human umbilical vein endothelial cells by CD226].
OBJECTIVE
To provide the morphological evidence on participating in the adhesive function of human umbilical vein endothelial cells by CD226.


METHODS
Human umbilical vein endothelial cells(HUVECs) were cultured and the effect of CD226 on the adhesion between activated HUVEC and activated PBMC were observed by Leica inverted microscope and scanning electron microscope.


RESULTS
Fusion protein CD226/Ig could block the adhesion between activated HUVECs and activated PBMC markedly.


CONCLUSIONS
CD226 was a novel inducible adhesion molecule expressed on activated endothelial cells, which may possess important physiological and pathological function.
Chen
Li-Hua
LH
Department of Immunology, Fourth Military Medical University, Xi'an 710032, China.
Zhang
Xin-Hai
XH
She
Yi-Chao
YC
Liu
Xue-Song
XS
Jin
Bo-Quan
BQ
D000269:Adhesives; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000378:metabolism; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000378:metabolism
D000269:Adhesives; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1