title: A new entry of nucleophiles in rhodium-catalyzed asymmetric 1,4-addition reactions: addition of organozinc reagents for the synthesis of 2-aryl-4-piperidones.
abstract: A rhodium-catalyzed asymmetric 1,4-addition reaction has been applied to the synthesis of 2-aryl-4-piperidones. While other conventional nucleophiles fail, organozinc reagents have been successfully utilized for the construction of these useful compounds in very good yield and enantiomeric excess.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shintani
authors.forename: Norihito
authors.initials: N
authors.lastname: Tokunaga
authors.forename: Hidenori
authors.initials: H
authors.lastname: Doi
authors.forename: Tamio
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D002384:Catalysis; D007202:Indicators and Reagents; D009942:Organometallic Compounds / Q000737:chemistry; D010881:Piperidones / Q000138:chemical synthesis*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D015320:Tachykinins / Q000037:antagonists & inhibitors; D015032:Zinc / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D009942:Organometallic Compounds; D010881:Piperidones; D015320:Tachykinins; D012238:Rhodium; D015032:Zinc