title: Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation.
abstract: A series of substituted styryl-acrylonitriles was designed and synthesized. The new compounds, called tyrenes, were tested for the ability to inhibit acute lymphocytic leukemia (ALL) cancer cell growth, as well as on their toxicity to normal bone marrow (NBM) cells. The results showed that 3,4-dihydroxystyryl-acrylonitriles, in particular CR-4, revealed great potency as antitumor agents, and also exhibited low toxicity to normal cells. The effectiveness of these compounds with extended conjugation may be due to their possible functioning as reactive Michael acceptors.
authors.affiliation: Division of Immunology and Allergy, Infection, Immunity, Injury and Repair Program, Research Institute, and The Hospital for Sick Children and University of Toronto, Toronto, Canada M5G 1X8.
authors.forename: Peter
authors.initials: P
authors.lastname: Demin
authors.forename: Olga
authors.initials: O
authors.lastname: Rounova
authors.forename: Thomas
authors.initials: T
authors.lastname: Grunberger
authors.forename: Lorand
authors.initials: L
authors.lastname: Cimpean
authors.forename: Nigel
authors.initials: N
authors.lastname: Sharfe
authors.forename: Chaim M
authors.initials: CM
authors.lastname: Roifman
mesh_terms: D000181:Acrylonitrile / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D013343:Styrenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013343:Styrenes; D000181:Acrylonitrile