Bone marrow transplantation for therapy-related acute myeloid leukemia in congenital retinoblastoma associated with 13q deletion syndrome.
Children with constitutional deletion of the long arm of chromosome 13 are at risk for retinoblastoma (RB) due to loss of the RB tumor suppressor gene. The prognosis is poor since the tumors are often bilateral, aggressive, and recurrent and the patients often harbor other congenital abnormalities. One further complication is that of therapy-related malignancies later in life. We report a case of allogeneic stem cell transplantation for therapy-related acute myeloid leukemia in an 8-year-old girl after multimodality treatment for refractory bilateral relapsing RB, with excellent outcome in both the ophthalmic and marrow disease.
Hon
C
C
Department of Ophthalmology, Queen Mary Hospital, Hong Kong, China.
Chan
G C F
GC
Ha
S Y
SY
Ma
S K
SK
Wong
K F
KF
Au
W Y
WY
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13 / Q000648:ultrastructure*; D003452:Cryosurgery; D017679:Cryotherapy; D016572:Cyclosporine / Q000008:administration & dosage; D004268:DNA-Binding Proteins / Q000235:genetics; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D005134:Eye Neoplasms / Q000151:congenital / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007231:Infant, Newborn; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000235:genetics / Q000628:therapy*; D051788:Myeloid-Lymphoid Leukemia Protein; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary / Q000151:congenital / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000139:chemically induced / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation; D011519:Proto-Oncogenes; D012074:Remission Induction; D012175:Retinoblastoma / Q000151:congenital / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy / Q000601:surgery; D013713:Teniposide / Q000008:administration & dosage; D059005:Topoisomerase II Inhibitors; D014157:Transcription Factors; D014750:Vincristine / Q000008:administration & dosage
D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; C497422:KMT2A protein, human; D009363:Neoplasm Proteins; D059005:Topoisomerase II Inhibitors; D014157:Transcription Factors; D051788:Myeloid-Lymphoid Leukemia Protein; D014750:Vincristine; D016572:Cyclosporine; D013713:Teniposide; D016190:Carboplatin; D011495:Histone-Lysine N-Methyltransferase