Major shifts in genomic activity accompany progression through different stages of the hair cycle.
Hair follicles display a unique pattern of cyclic growth and regression involving cell proliferation, differentiation and migration. The molecular details of these processes are largely unexplored. Global expression analyses on the basis of about 20,000 genes for each morphologically distinguishable stage of the hair cycle revealed unexpected complexities of and major temporal shifts in transcriptional programs involving about 13% of all genes. In particular, hundreds of genes characterise the pattern of genomic activity during regression and resting phases; selected genes can be used to monitor hair growth in mice. We demonstrate that temporal expression patterns predict gene expression domains within the hair follicle. Expression of insulin-like growth factor binding proteins and anti-angiogenic factors is associated with the regression phase of the hair cycle.
Schlake
Thomas
T
Department of Developmental Immunology, Max-Planck-Institute of Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany. schlake@immunbio.mpg.de
Beibel
Martin
M
Weger
Nicole
N
Boehm
Thomas
T
D043925:Angiogenesis Inducing Agents / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019295:Computational Biology; D015870:Gene Expression / Q000502:physiology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000502:physiology; D018859:Hair Follicle / Q000378:metabolism*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D015398:Signal Transduction / Q000502:physiology; D013002:Somatomedins / Q000378:metabolism; D013997:Time Factors
D043925:Angiogenesis Inducing Agents; D013002:Somatomedins