title: Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date.
abstract: Renal neoplasms are not necessarily high in frequency, but they are characteristic in their heterogeneity and occasional association with systemic familial tumor syndromes and phacomatoses (e.g. clear cell renal cell carcinoma and von Hippel-Lindau disease, Wilms tumor and aniridia, genitourinary malformation and mental retardation (so-called, WAGR syndrome), and angiomyolipoma and tuberous sclerosis). Physicians and pathologists should take note of these syndromes and associated renal neoplasms because they have provided important clues to elucidate the mechanism of tumorigenesis concerning cancer-suppressor genes. This review aims to present recent classification of renal parenchymal neoplasms based on their molecular biological characteristics, and future problems yet to be clarified.
authors.affiliation: Department of Molecular Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. ynagas@med.yokohama-cu.ac.jp
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Inayama
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Kato
authors.forename: Naoki
authors.initials: N
authors.lastname: Sakai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanno
authors.forename: Ichiro
authors.initials: I
authors.lastname: Aoki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yao
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology*; D000236:Adenoma / Q000235:genetics* / Q000473:pathology*; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology*