Genetic basis of erythromycin resistance in oral bacteria.
We determined the prevalence of erythromycin-resistant bacteria in the oral cavity and identified mef and erm(B) as the most common resistance determinants. In addition, we demonstrate the genetic linkage, on various Tn1545-like conjugative transposons, between erythromycin and tetracycline resistance in a number of isolates.
Villedieu
A
A
Division of Infection and Immunity, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray's Inn Rd., London WC1X 8LD, United Kingdom.
Diaz-Torres
M L
ML
Roberts
A P
AP
Hunt
N
N
McNab
R
R
Spratt
D A
DA
Wilson
M
M
Mullany
P
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D015139:Blotting, Southern; D004251:DNA Transposable Elements / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*; D010957:Plasmids / Q000235:genetics; D011496:Protein Methyltransferases / Q000235:genetics; D013753:Tetracycline Resistance; D014157:Transcription Factors / Q000235:genetics
D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; C111931:ELF4 protein, human; C086680:ETV5 protein, human; D014157:Transcription Factors; D004917:Erythromycin; D011496:Protein Methyltransferases