A simple stereocontrolled synthesis of salinosporamide A.
A simple and effective stereocontrolled synthesis of salinosporamide A has been developed. This process, the first synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. Salinosporamide A was of special interest as a synthetic target because of its potent in vitro cytotoxic activity against many tumor cell lines (IC(50) values of 10 nM or less).
Reddy
Leleti Rajender
LR
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Saravanan
P
P
Corey
E J
EJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D011758:Pyrroles; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007783:Lactones; D011758:Pyrroles; C475865:marizomib