New constituents of Artemisia monosperma.
A new eudesmane sesquiterpene (1) and a C(10) diyne (2) were isolated from the aerial parts of Artemisia monosperma. The structures of these compounds were determined as rel-1beta,3alpha,6beta-trihydroxyeudesm-4-ene (1) and 1,3R,8R-trihydroxydec-9-en-4,6-yne (2) on the basis of spectral data interpretation. The absolute stereochemistry of 2 was determined using Mosher ester methodology in which the terminal primary hydroxyl group was first protected to simplify the stereochemical analysis.
Stavri
Michael
M
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, London, WC1N 1AX, UK.
Mathew
K Thomas
KT
Gibson
Trevor
T
Williamson
R Thomas
RT
Gibbons
Simon
S
D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019306:Artemisia / Q000737:chemistry*; D053280:Diynes; D005233:Fatty Alcohols / Q000494:pharmacology; D007730:Kuwait; D016106:Methicillin Resistance; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013237:Stereoisomerism
C487253:1,3,8-trihydroxydec-9-en-4,6-yne; D000480:Alkynes; D053280:Diynes; D005233:Fatty Alcohols; D045787:Sesquiterpenes, Eudesmane; C487252:rel-1,3,6-trihydroxyeudesm-4-ene; C034379:falcarindiol