[Colforsin daropate does not affect the cerebral blood-flow in cardiac surgery patients under cardiopulmonary bypass].
BACKGROUND
Cerebral blood flow partly plays a pivotal role in cerebral complications among cardiac surgery patients. We evaluated the effect of colforsin daropate (colforsin) on cerebral blood flow in cardiac surgery patients under cardiopulmonary bypass (CPB) by transcranial Doppler sonography (TCD).


METHODS
Eighteen patients scheduled for coronary artery bypass surgery under CPB were assigned randomly to two groups:colforsin group (n=9) and control group (n=9). We assessed cardiac function by measuring cardiac index (CI) and systemic vascular resistance index (SVRI). Cerebral blood flow was evaluated by measuring the peak systolic blood flow velocity (Vs), end-diastolic blood flow velocity (Vd) together with mean blood flow velocity (Vm), and calculated the pulsatility index (PI) in the left carotid siphon by TCD. After baseline measurement, the colforsin loading dosage was increased from 0.25 to 0.5 microg x kg(-1) x min(-1) in colforsin group every 60 minutes.


RESULTS
Colforsin significantly increased CI and decreased SVRI compared with pre-levels. In both groups there were no significant changes in Vs, Vd, Vm and PI.


CONCLUSIONS
We have demonstrated that colforsin is effective for hemodynamics without cerebral blood flow change in cardiac surgery patients under cardiopulmonary bypass.
Goto
Koji
K
Department of Anesthesiology, Oita University School of Medicine, Oita 879-5593.
Mizutani
Akio
A
Shingu
Chihiro
C
Hasegawa
Akira
A
Hidaka
Seigo
S
Ito
Koji
K
Iwasaka
Hideo
H
Noguchi
Takayuki
T
D000368:Aged; D002315:Cardiopulmonary Bypass; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002493:Central Nervous System Diseases / Q000517:prevention & control; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D005576:Colforsin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use*; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011184:Postoperative Period; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D014665:Vasodilator Agents; C122001:colforsin daropate; D005576:Colforsin