title: The simplex (differentiated) variant of vulvar intraepithelial neoplasia.
abstract: BACKGROUND
  The simplex (differentiated) variant of vulvar intraepithelial neoplasia is rarely reported. It is regarded as more likely than "classic" carcinoma in situ to be associated with invasion and can be easily mistaken for benign lesions.
  
  
  OBJECTIVE
  The objective was to present a case of simplex variant of vulvar intraepithelial neoplasia in a 67-year-old woman that was initially misdiagnosed as lichen simplex chronicus.
  
  
  METHODS
  A case report is reported and the literature is reviewed.
  
  
  RESULTS
  Surgical excision with a free margin of 5 mm was performed and no evidence of recurrence was noted during the follow-up period of 6 months.
  
  
  CONCLUSIONS
  The simplex vulvar intraepithelial neoplasia is an easily overlooked premalignant disease, and it can be cured with surgical treatment if diagnosed correctly and early.
authors.affiliation: Department of Dermatology, Chang-Gung Memorial Hospital, Kaohsiung, Taiwan.
authors.forename: Meng-Yueh
authors.initials: MY
authors.lastname: Hsieh
authors.forename: Hung-Wen
authors.initials: HW
authors.lastname: Kuo
mesh_terms: D000368:Aged; D002278:Carcinoma in Situ / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009450:Neurodermatitis / Q000175:diagnosis / Q000473:pathology; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology