Clinical manifestation of aldosteronoma.
Formerly, fewer than 1% of patients with hypertension were believed to have primary hyperaldosteronism; however, recent studies have suggested a higher prevalence, in 5% to 10% of patients with hypertension. Hypokalemia is not necessary for the diagnosis and is probably a sign of more advanced disease. The best diagnostic test is the plasma aldosterone concentration to plasma renin activity (PAC/PRA) ratio. Excess aldosterone level has a deleterious effect on the cardiovascular system. Aldosteronomas should be differentiated from idiopathic hyperaldosteronism (IHA),because they are curable by laparoscopic adrenalectomy.
Al Fehaily
Maha
M
Department of Surgery, University of Toronto, 100 College Street, Toronto, ON, M5G 1L5, Canada.
Duh
Quan-Yang
QY
D000236:Adenoma / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D000315:Adrenalectomy; D003937:Diagnosis, Differential; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006973:Hypertension / Q000209:etiology / Q000628:therapy; D000451:Mineralocorticoid Receptor Antagonists / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use
D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone