title: [The significance of fluorescent patterns of antineutrophil cytoplasmic antibodies (ANCA) in renal diseases].
abstract: OBJECTIVE
  To further explore significance of fluorescent patterns of antineutrophil cytoplasmic antibodies in renal diseases.
  
  
  METHODS
  ANCA fluorescent patterns and its target antigens in sera of 251 patients with renal diseases were detected by indirect immunofluorescence (IIF) and ELISA.
  
  
  RESULTS
  The positive percentage of ANCA is 20.3% (51/251), in which 3.98%(10/251) is cANCA, 11.95% (30/251) pANCA and 4.38%(11/251) aANCA.
  
  
  CONCLUSIONS
  The simultaneous screening for ANCA and its target antigens by IIF and ELISA can increase the positive percentage of ANCA in renal diseases. This novel screening strategy is able to distinguish atypical ANCA(aANCA) from pANCA with ANA and therefore useful for differential diagnosis between vasculitis and autoimmune diseases.
authors.affiliation: Department of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yue-Qing
authors.initials: YQ
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Zhen-Jiang
authors.initials: ZJ
authors.lastname: Li
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Liu
authors.forename: Han-Min
authors.initials: HM
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007674:Kidney Diseases; D053146:Myeloblastin; D009195:Peroxidase; D014657:Vasculitis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase; D053146:Myeloblastin