A possible transport mechanism for aluminum in biological membranes.
The transport mechanism of aluminum in lysosomes extracted from rat liver has been investigated in this paper. The experimental evidence supports the hypothesis that aluminum is transported inside lysosomes in the form of an Al(OH)(3) electroneutral compound, the driving force being the internal acidic pH. This mechanism could help to explain the presence of aluminum in cells in many illnesses.
Bragadin
Marcantonio
M
Dipartimento di Scienze Ambientali, Università di Venezia, DD 2137, 30123 Venice, Italy. bragadin@unive.it
Manente
Sabrina
S
Scutari
Guido
G
Rigobello
Maria Pia
MP
Bindoli
Alberto
A
D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D017136:Ion Transport / Q000502:physiology; D008099:Liver / Q000473:pathology / Q000502:physiology*; D008247:Lysosomes / Q000378:metabolism*; D008564:Membrane Potentials / Q000502:physiology; D051381:Rats
D000535:Aluminum