[The effect of FN(fibronectin) on invasion and metastasis of human acinic cell carcinoma cell strain of the salivary gland]
FN distribution in ACC-2 and high lung-metastatic ACC-M cells was studied with immunohistochemical staining.There were less FN found in ACC-2,but much more FN were observed in the highly metastatic clone Acc-M.In vitro motility of two cell lines was measured by Boyden chamber.With the presence of exgenous FN,Acc-2 became activated with a higher migration rate.The cell adhesion test showed that Acc-2 had stronger ability of adhesion than Acc-M with the presence of FN.The result suggested FN may play a vital role in the invasion and metastasis of ACC.
Shi
H N
HN
Department of Oral and Maxillofacial Surgery, School of Stomatlolgy, Shanghai Second Medical University. Shanghai 200011, China.
He
R G
RG
Zhou
X J
XJ