title: Impact of tobacco smoking on platelet function in apheresis products in vitro.
abstract: OBJECTIVE
  The aim of this study was to analyse the platelet function, over a 5-day time-period, of apheresis-derived platelet concentrates obtained from smokers and non-smokers.
  
  
  METHODS
  Smoker and non-smoker plateletpheresis products were investigated on days 1, 3 and 5 of storage. Receptor expression (as evaluated by flow cytometry) and the platelet aggregation response were measured.
  
  
  RESULTS
  There was only a slight loss of platelet function in apheresis products from smokers compared to non-smokers.
  
  
  CONCLUSIONS
  Smoking does not significantly change the quality of platelet preparations. The current practice, of not to exclude smokers from platelet donation, can be continued.
authors.affiliation: Department of Anaesthesiology, Hannover Medical School, Hannover, Germany. scheinichen.dirk@mh-hannover.de
authors.forename: D
authors.initials: D
authors.lastname: Scheinichen
authors.forename: H-G
authors.initials: HG
authors.lastname: Heuft
authors.forename: C
authors.initials: C
authors.lastname: Renken
authors.forename: B
authors.initials: B
authors.lastname: Jüttner
authors.forename: K
authors.initials: K
authors.lastname: Jaeger
authors.forename: T
authors.initials: T
authors.lastname: Schürholz
authors.forename: R
authors.initials: R
authors.lastname: Blasczyk
authors.forename: S
authors.initials: S
authors.lastname: Piepenbrock
authors.forename: H-A
authors.initials: HA
authors.lastname: Elsner
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D001793:Blood Preservation; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D010980:Platelet Membrane Glycoproteins / Q000032:analysis; D010983:Plateletpheresis; D012907:Smoking / Q000097:blood*
chemical_list: D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D000244:Adenosine Diphosphate; D003094:Collagen; D004837:Epinephrine