Encephalopathy secondary to imipenem therapy.
We describe the case of an 84-year-old woman who developed a confusional state and suffered from a generalized tonic-clonic seizure while she was treated with imipenem, a beta-lactam antibiotic. Focal and generalized epileptiform discharges and a photoparoxysmal response were prominent with transient changes on the EEG.
Fernández-Torre
J L
JL
Department of Clinical Neurophysiology, Hospital Universitario "Marqués de Valdecilla", Santander, Cantabria, Spain. jlfernandez@humv.es
Velasco
M
M
Gutiérrez
R
R
Fernández-Sampedro
M
M
D000151:Acinetobacter Infections / Q000097:blood / Q000188:drug therapy; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D015378:Imipenem / Q000009:adverse effects* / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000097:blood / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000097:blood / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D015378:Imipenem