[Detection of high-sensitivity C-reactive protein and total cholesterol/high-density lipoprotein cholesterol ratio for diagnosis of coronary artery disease].
OBJECTIVE
To study the value of detecting high-sensitivity C-reactive protein (hs-CRP) combined with determination of total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) in the diagnosis of coronary artery disease (CHD).


METHODS
A total of 240 patients with documented CHD and 40 healthy subjects were enrolled in this study for measurement of serum concentrations of hs-CRP, TC and HDL-C.


RESULTS
The concentration of hs-CRP and TC/HDL-C ratio was significantly higher in CHD patients than in the control subjects (P<0.01). The positivity rate by detecting both the two markers (0.950) was higher than that of single marker detection of either hs-CRP (0.850) or TC/HDL-C (vs 0.767).


CONCLUSIONS
Detection of hs-CRP combined with determination of TC/HDL-C may facilitate early diagnosis of CHD.
Jiang
Chao-xin
CX
Department of Clinical Laboratory, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China.
Li
Zhi-liang
ZL
Yan
Quan-neng
QN
D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D008076:Cholesterol, HDL; D002097:C-Reactive Protein; D002784:Cholesterol