Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity.
6A,6B-Dideoxy-6A,6B-di[(N-salicylidene)amino]-beta-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N(')-bis-(salicylidene)ethane-1,2-diamine (SalenH(2)) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown.
Puglisi
Antonino
A
Dipartimento di Scienze Chimiche, Università di Catania, viale A. Doria 8, 95125 Catania, Italy.
Tabbì
Giovanni
G
Vecchio
Graziella
G
D002374:Catalase / Q000737:chemistry; D003505:Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry*; D008024:Ligands; D008345:Manganese / Q000737:chemistry*; D017895:Manganese Compounds / Q000737:chemistry*; D009942:Organometallic Compounds; D013482:Superoxide Dismutase / Q000737:chemistry*
D003505:Cyclodextrins; D005029:Ethylenediamines; D008024:Ligands; D017895:Manganese Compounds; D009942:Organometallic Compounds; D008345:Manganese; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); C011452:disalicylaldehyde ethylenediamine; D002374:Catalase; D013482:Superoxide Dismutase