title: Caenorhabditis elegans functional genomics: omic resonance.
abstract: The nematode Caenorhabditis elegans is widely used as a model organism for studying many fundamental aspects of development and cell biology, including processes underlying human disease. The genome of C. elegans encodes over 19,000 protein-coding genes and hundreds of non-coding RNAs. The availability of whole genome sequence has facilitated the development of high throughput techniques for elucidating the function of individual genes and gene products. Furthermore, attempts can now be made to integrate these substantial functional genomics data collections and to understand at a global level how the flow of genomic information that is at the core of the central dogma leads to the development of a multicellular organism.
authors.affiliation: Department of Biochemistry, University of Bristol, The School of Medical Sciences, University Walk, Bristol BS8 1TD, UK.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Astin
authors.forename: Alyce
authors.initials: A
authors.lastname: Merry
authors.forename: Jeena
authors.initials: J
authors.lastname: Rajan
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Kuwabara
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D017930:Genes, Reporter; D016678:Genome; D020411:Oligonucleotide Array Sequence Analysis; D020543:Proteome; D012313:RNA / Q000737:chemistry; D034622:RNA Interference; D014158:Transcription, Genetic
chemical_list: D020543:Proteome; D012313:RNA