[Therapeutic effect of Chinese herbal medicines for nourishing blood and reinforcing shen in treating patients with anovulatory sterility of shen-deficiency type and its influence on the hemodynamics in ovarian and uterine arteries].
OBJECTIVE
To observe the clinical therapeutic effect of Nuzhen Yunyu Decoction (NYD, a Chinese recipe for nourishing blood and reinforcing Shen) and its influence on the hemodynamic parameters in ovarian and uterine arteries.


METHODS
Sixty-eight patients were randomly divided into two groups at the ratio of 2:1, 45 in the TCM group treated with Chinese medicine and 23 in the control group treated with clomiphene citrate. Menstrual cycle were taken as the indexes for clinical observation; basal body temperature, cervical mucus, vaginal exfoliative cells, serum hormones and B ultrasonic examination were taken as the indexes for ovulation and pregnancy assessment. The hemodynamic parameters of uterus and ovary were determined by using color Doppler ultrasonography, and the growth of follicles and ovulation, thickness of uterine endometrium were also monitored continuously.


RESULTS
Results of 3 cycles treatment and 1 year follow-up study showed that the ovulation promoting rate, pregnancy rate and abortion rate in the two groups were similar, but the treated group showed better effects than that of control group, in such aspects as regulating menstruation, promoting growth and development of follicle, strengthening endometrium, improving blood supply and circulation of uterine and ovary (P < 0.05, P < 0.01).


CONCLUSIONS
NYD has the effects of ovulation promotion and holistic regulation of reproductive system.
Xia
Yu-wei
YW
Xiyuan Hospital, China Academy of TCM, Beijing 100091.
Cai
Lian-xiang
LX
Zhang
Shu-cheng
SC
D000328:Adult; D000858:Anovulation / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000209:etiology; D010053:Ovary / Q000098:blood supply*; D010062:Ovulation Induction; D008517:Phytotherapy; D014599:Uterus / Q000098:blood supply*; D016710:Yin Deficiency / Q000188:drug therapy
D004365:Drugs, Chinese Herbal