title: Retrograde transport of cholera toxin into the ER of host cells.
abstract: Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Here we discuss recent studies on the mechanism of transport from plasma membrane to the ER and on the reactions that unfold and retrotranslocate a portion of the toxin to the cytosol where toxicity is induced.
authors.affiliation: GI Cell Biology, Children's Hospital Boston, Harvard Digestive Diseases Center, Department of Pediatrics Harvard Medical School, Boston, MA 02115, USA. wayne.lencer@tch.harvard.edu
authors.forename: Wayne I
authors.initials: WI
authors.lastname: Lencer
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D002772:Cholera Toxin / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D021381:Protein Transport
chemical_list: D005677:G(M1) Ganglioside; D002772:Cholera Toxin; D002784:Cholesterol