Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women.
OBJECTIVE
To further investigate the role of prior medical conditions and medication use in the etiology of non-Hodgkin lymphoma (NHL), we analyzed the data from a population-based case-control study of NHL in Connecticut women.


METHODS
A total of 601 histologically confirmed incident cases of NHL and 717 population-based controls were included in this study. In-person interviews were administered using standardized, structured questionnaires to collect information on medical conditions and medication use.


RESULTS
An increased risk was found among women who had a history of autoimmune disorders (such as rheumatoid arthritis, lupus erythematosus, Sjogren's syndrome, and multiple sclerosis), anemia, eczema, or psoriasis. An increased risk was also observed among women who had used steroidal anti-inflammatory drugs and tranquilizers. A reduced risk was found for women who had scarlet fever or who had used estrogen replacement therapy, aspirin, medications for non-insulin dependent diabetes, HMG-CoA reductase inhibitors, or beta-adrenergic blocking agents. Risk associated with past medical history appeared to vary based on NHL subtypes, but the results were based on small number of exposed subjects.


CONCLUSIONS
A relationship between certain prior medical conditions and medication use and risk of NHL was observed in this study. Further studies are warranted to confirm our findings.
Zhang
Yawei
Y
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA.
Holford
Theodore R
TR
Leaderer
Brian
B
Zahm
Shelia Hoar
SH
Boyle
Peter
P
Morton
Lindsay McOmber
LM
Zhang
Bing
B
Zou
Kaiyong
K
Flynn
Stuart
S
Tallini
Giovanni
G
Owens
Patricia H
PH
Zheng
Tongzhang
T
D000328:Adult; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000740:Anemia / Q000150:complications; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001327:Autoimmune Diseases / Q000150:complications; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D004485:Eczema / Q000150:complications; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D008487:Medical History Taking; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D014149:Tranquilizing Agents / Q000009:adverse effects; D016387:Women's Health
D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D014149:Tranquilizing Agents