HIV-1 assembly and maturation.
HIV-1 particles have been studied by structural and chemical approaches, however, the processes of assembly, budding and maturation are just beginning to be characterized, and molecular details of these processes remain poorly defined. This brief review summarizes some recent findings on the final steps of the HIV-1 life cycle and touches upon some unanswered questions, particularly regarding the processes involved in virus maturation and infectivity.
Bukrinskaya
A G
AG
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, U.S.A. Alissa.Bukrinskaya@umassmed.edu
D000818:Animals; D015683:Gene Products, gag / Q000737:chemistry / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology / Q000821:virology; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication
D015683:Gene Products, gag; D011498:Protein Precursors; C059767:p55 gag precursor protein, Human immunodeficiency virus 1