title: Occurrence of neural tube defects and Down syndrome among siblings.
abstract: A recent study had reported increased risk of Down syndrome among siblings of Infants with neural tube defects (NTDs) and vice versa. However Hawaii Birth Defects Registry data indicate no elevated risk of Down syndrome among older siblings of infants with NTDs and vice versa, contradicting the findings of the previous study. Further investigation of the potential relationship is warranted.
authors.affiliation: Hawaii Birth Defects Program, Honolulu, HI 96817, USA.
authors.forename: Mathias B
authors.initials: MB
authors.lastname: Forrester
authors.forename: Ruth D
authors.initials: RD
authors.lastname: Merz
mesh_terms: D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000453:epidemiology / Q000235:genetics*; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007223:Infant; D009436:Neural Tube Defects / Q000453:epidemiology / Q000235:genetics*; D012042:Registries / Q000706:statistics & numerical data