Synthesis of analogues of a potent antitumor saponin OSW-1.
A series of side chain analogues (5a-e), a 22-glycosylated isomer (10), and 16beta-O-l-arabinosyl (13a) or 16beta-O-d-xylosyl (13b) analogues of OSW-1 were synthesized. All analogues were found to be less cytotoxic against breast and endometrial cancer cell lines than the natural product.
Morzycki
Jacek W
JW
Institute of Chemistry, University of Bialystok, al. Pilsudskiego 11/4, 15-443 Bialystok, Poland. morzycki@uwb.edu.pl
Wojtkielewicz
Agnieszka
A
Wołczyński
Sławomir
S
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002783:Cholestenones / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D031442:Ornithogalum; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; D012503:Saponins; C106408:OSW 1