title: Synthesis of 4-fluorinated UDP-MurNAc pentapeptide as an inhibitor of bacterial growth.
abstract: 4-Fluorinated UDP-MurNAc pentapeptide, 2, has been synthesized. In our previous study, UDP-MurNAc pentapeptide analogue 1 was found to be incorporated into the bacterial cell wall through biosynthesis. Compound 2 showed growth-inhibition activity against Gram-positive bacteria when it was added to growth media at 0.01 mg/mL. [structure--see text]
authors.affiliation: Bio-Macromolecular Chemistry Lab, Division of Biological Sciences, Graduate School of Science, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University, Kita 21, Nishi 11, Sapporo 001-0021 Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Ueda
authors.forename: Fei
authors.initials: F
authors.lastname: Feng
authors.forename: Reiko
authors.initials: R
authors.lastname: Sadamoto
authors.forename: Kenichi
authors.initials: K
authors.lastname: Niikura
authors.forename: Kenji
authors.initials: K
authors.lastname: Monde
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development*; D002455:Cell Division / Q000187:drug effects; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D009842:Oligopeptides