[Sensory neurons of metasympathetic (intramural) ganglia in the guinea pig small intestine].
The hypothesis that multiaxonal neurons of the myenteric plexus of the small intestine are sensory neurons, was tested. The rising principle of the issue to sensory information in the metasympathetic ganglions of the small intestine was discovered by microapplication of the salt acid solution. Serotonin (5-hydroxytriptamine) and acetylcholine can participate in forming primary sensory signals in the multiaxonal neurons. Pulsed activity in primary sensory neurons by mucous perfusion of the small intestine by physiological solution with pH 3.5-3.8 was revealed. The enterochromaffin cells of the mucosa and multiaxonal neurons of the submucous and myenteric plexuses take part in reception of the salt acid.
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I. P. Pavlov Istitute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
D000200:Action Potentials; D000818:Animals; D005725:Ganglia, Autonomic / Q000166:cytology / Q000502:physiology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000294:innervation*; D008564:Membrane Potentials; D009197:Myenteric Plexus / Q000166:cytology / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology*