Bone and fat: old questions, new insights.
Until recently, adipose tissue was considered to serve only as a triglyceride reservoir and was relegated to a passive endocrine role. With the discovery of leptin and other adipokines, adipose tissue is now recognized as an active participant in systemic metabolism. This review focuses on the complex relationship existing between adipose tissue and bone metabolism and differentiation. It explores the paradigms that have shaped the past decade's research and what these findings forecast for the future. Particular attention is given to the multipotent adult stem cell populations that reside within bone and fat. These adult stem cells have critical importance to the emerging field of tissue engineering and regenerative medicine.
Gimble
Jeffrey M
JM
Pennington Biomedical Research Center, LSU, 6400 Perkins Rd, Baton Rouge, LA,70808, USA. gimblejm@pbrc.edu
Nuttall
Mark E
ME
D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D001854:Bone Marrow Cells / Q000166:cytology; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D008954:Models, Biological; D010006:Osteoblasts / Q000166:cytology; D013234:Stem Cells / Q000166:cytology; D017154:Stromal Cells / Q000166:cytology; D013329:Structure-Activity Relationship