Antigen bias in T cell cross-priming.
Activated CD8+ T cells detect virally infected cells and tumor cells by recognition of major histocompatibility complex class I-bound peptides derived from degraded, endogenously produced proteins. In contrast, CD8+ T cell activation often occurs through interaction with specialized antigen-presenting cells displaying peptides acquired from an exogenous cellular source, a process termed cross-priming. Here, we observed a marked inefficiency in exogenous presentation of epitopes derived from signal sequences in mouse models. These data indicate that certain virus- and tumor-associated antigens may not be detected by CD8+ T cells because of impaired cross-priming. Such differences in the ability to cross-present antigens should form important considerations in vaccine design.
Wolkers
Monika C
MC
Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands.
Brouwenstijn
Nathalie
N
Bakker
Arnold H
AH
Toebes
Mireille
M
Schumacher
Ton N M
TN
D000818:Animals; D017951:Antigen Presentation; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D045744:Cell Line, Tumor; D045142:Cross-Priming; D003713:Dendritic Cells / Q000276:immunology; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D007108:Immune Tolerance; D007136:Immunoglobulins / Q000276:immunology / Q000378:metabolism; D009980:Influenza A virus / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D027383:Papillomaviridae / Q000276:immunology; D021382:Protein Sorting Signals / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014162:Transfection; D014612:Vaccines / Q000276:immunology
D000956:Antigens, Viral; D018984:Epitopes, T-Lymphocyte; D007136:Immunoglobulins; D021382:Protein Sorting Signals; D011993:Recombinant Fusion Proteins; D014612:Vaccines