title: CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.
abstract: LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
authors.affiliation: Department of Microbiology and Immunology, 1 Medical Center Dr., Dartmouth Medical School, Lebanon, NH 03750, USA. Kathy.A.Green@dartmouth.edu
authors.forename: Kathy A
authors.initials: KA
authors.lastname: Green
authors.forename: Cory L
authors.initials: CL
authors.lastname: Ahonen
authors.forename: W James
authors.initials: WJ
authors.lastname: Cook
authors.forename: William R
authors.initials: WR
authors.lastname: Green
mesh_terms: D000818:Animals; D001665:Binding Sites; D019013:CD40 Antigens / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D016183:Murine Acquired Immunodeficiency Syndrome / Q000209:etiology*; D011506:Proteins / Q000502:physiology*; D048029:TNF Receptor-Associated Factor 6
chemical_list: D019013:CD40 Antigens; D011506:Proteins; D048029:TNF Receptor-Associated Factor 6