Myxoid liposarcoma with adipocytic maturation: detection of TLS/CHOP fusion gene transcript.
This report describes a 49-year-old woman with a well-circumscribed nodule of liposarcoma. The patient noticed a soft, slowly growing mass at the right sural region. Both axial computed tomography and magnetic resonance imaging revealed a soft tissue tumor consisting of nonfatty lesion measuring 5 x 3 x 3 cm circumscribed by a 1-cm thickened fatty area. Histologically, the tumor was made of 2 distinct components: the inner component of the tumor was a classic myxoid liposarcoma with numerous lipoblasts; the outer component was a lipoma-like lesion consisting of mature adipocytes without atypical nuclei. Immunohistochemically, MDM2 overexpression was observed and p53 immunophenotype was negative in both components. Molecular analysis revealed that type 1 TLS/ CHOP fusion gene transcript, characteristic of myxoid/round cell liposarcoma, was detected in both areas.
Nakanishi
Hirofumi
H
Departments of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. h-nakanishi@mvf.biglobe.ne.jp
Araki
Nobuhito
N
Joyama
Susumu
S
Higuchi
Chikahisa
C
Mano
Masayuki
M
Ishiguro
Shingo
S
Itoh
Kazuyuki
K
Ueda
Takafumi
T
Yoshikawa
Hideki
H
D017667:Adipocytes / Q000378:metabolism / Q000473:pathology*; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D007866:Leg / Q000473:pathology; D018208:Liposarcoma, Myxoid / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2; D034702:RNA-Binding Protein FUS / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D051742:Transcription Factor CHOP; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D034702:RNA-Binding Protein FUS; C106030:TLS-CHOP fusion protein, human; D016159:Tumor Suppressor Protein p53; D051742:Transcription Factor CHOP; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2