Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis.
A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.
Pagano
Michele
M
Department of Pathology, New York University School of Medicine and NYU Cancer Institute, 550 First Avenue, MSB 599, New York, NY 10016, USA.
D000818:Animals; D016203:CDC2 Protein Kinase / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D004261:DNA Replication / Q000235:genetics*; D016195:G2 Phase / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008938:Mitosis / Q000235:genetics*; D044786:S-Phase Kinase-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D044843:SKP Cullin F-Box Protein Ligases / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics*
C493961:Cdkn1b protein, mouse; D018797:Cell Cycle Proteins; D044786:S-Phase Kinase-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D044843:SKP Cullin F-Box Protein Ligases; D016203:CDC2 Protein Kinase