title: Role of prehypertension in the development of coronary atherosclerosis in Japan.
abstract: BACKGROUND
  Hypertension is an important risk factor of coronary heart disease. A new guidelines for hypertension prevention and management in The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure in the United States recommended lifestyle modification or medical treatment for subjects with prehypertension. However, whether prehypertension increases the risk of coronary atherosclerosis in the Japanese population is still unknown.
  
  
  METHODS
  A cross-sectional study in a clinical setting was conducted. The subjects were 705 patients (417 males and 288 females) aged 30 years and older who underwent a first-time coronary angiography for suspected or known coronary heart disease at 5 major cardiology departments in the Fukuoka metropolitan area between September 1996 and August 1997.
  
  
  RESULTS
  Compared to subjects with normal blood pressure, those with prehypertension had an increased risk of coronary atherosclerosis even after adjusting for other factors.
  
  
  CONCLUSIONS
  Prehypertension may be an important clinical entity which requires treatment in the Japanese population.
authors.affiliation: Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Washio
authors.forename: Shoji
authors.initials: S
authors.lastname: Tokunaga
authors.forename: Kouichi
authors.initials: K
authors.lastname: Yoshimasu
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kodama
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Shizuka
authors.initials: S
authors.lastname: Sasazuki
authors.forename: Keitaro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Suminori
authors.initials: S
authors.lastname: Kono
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mohri
authors.forename: Akira
authors.initials: A
authors.lastname: Takeshita
authors.forename: Kikuo
authors.initials: K
authors.lastname: Arakawa
authors.forename: Munehito
authors.initials: M
authors.lastname: Ideishi
authors.forename: Takanobu
authors.initials: T
authors.lastname: Nii
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shirai
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Arai
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Doi
authors.forename: Tomoki
authors.initials: T
authors.lastname: Kawano
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakagaki
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Takada
authors.forename: Koji
authors.initials: K
authors.lastname: Hiyamuta
authors.forename: Samon
authors.initials: S
authors.lastname: Koyanagi
mesh_terms: D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000209:etiology*; D023921:Coronary Stenosis / Q000150:complications*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007564:Japan; D008019:Life Style; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors