title: Anticonvulsant activity of Mimosa pudica decoction.
abstract: The decoction of Mimosa pudica leaves given intraperitoneally at dose of 1000-4000 mg/kg protected mice against pentylentetrazol and strychnine-induced seizures. M. pudica had no effect against picrotoxin-induced seizures It also antagonized N-methyl-D-aspartate- induced turning behavior. These properties could explain its use in African traditional medicine.
authors.affiliation: Département des Sciences Biologiques, Faculté des Sciences, Université de Ngaoundéré B.P. 454 Ngaoundéré, BP, Cameroon. eli_bum@yahoo.fr
authors.forename: E
authors.initials: E
authors.lastname: Ngo Bum
authors.forename: D L
authors.initials: DL
authors.lastname: Dawack
authors.forename: M
authors.initials: M
authors.lastname: Schmutz
authors.forename: A
authors.initials: A
authors.lastname: Rakotonirina
authors.forename: S V
authors.initials: SV
authors.lastname: Rakotonirina
authors.forename: C
authors.initials: C
authors.lastname: Portet
authors.forename: A
authors.initials: A
authors.lastname: Jeker
authors.forename: H-R
authors.initials: HR
authors.lastname: Olpe
authors.forename: P
authors.initials: P
authors.lastname: Herrling
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D016488:Medicine, African Traditional; D051379:Mice; D031298:Mimosa; D010433:Pentylenetetrazole; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013331:Strychnine
chemical_list: D000927:Anticonvulsants; D010936:Plant Extracts; D013331:Strychnine; D010433:Pentylenetetrazole