Mise en place-this bud's for the Golgi.
Selective cargo export from the endoplasmic reticulum is brought about by the budding of COPII vesicles. While the main structural components of the COPII coat have been identified and characterized, the regulatory event(s) promoting COPII vesicle biogenesis and cargo selection still remains largely unknown. New data by Glick and colleagues suggest that Sec12 and COPII function may be downstream of important early events coordinated by transitional ER (tER) exit sites.
LaPointe
Paul
P
The Scripps Research Institute, Department of Cell, and The Institute for Childhood and Neglected Disease, 10550 N. Torrey Pines Road, La Jolla, CA 92130, USA.
Gurkan
Cemal
C
Balch
William E
WE
D000818:Animals; D022181:COP-Coated Vesicles / Q000378:metabolism* / Q000648:ultrastructure; D004268:DNA-Binding Proteins; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism / Q000648:ultrastructure; D008954:Models, Biological; D021381:Protein Transport / Q000502:physiology; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D020662:Guanine Nucleotide Exchange Factors; C118971:PREB protein, human; D014157:Transcription Factors