title: The ageless question--what accounts for age-related cognitive decline?
abstract: Recent studies have provided partial insight into mechanisms underlying age-related declines in brain function. However, precisely where in the brain these changes occur is not entirely clear. A new report suggests that the hippocampal dentate gyrus may be the earliest locus of age-related memory decline.
authors.affiliation: Department of Neurosciences, University of California-San Diego, La Jolla, CA 92093, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Nagahara
authors.forename: Mark H
authors.initials: MH
authors.lastname: Tuszynski
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D018891:Dentate Gyrus / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D009124:Muscle Proteins / Q000096:biosynthesis
chemical_list: D051017:Apoptosis Regulatory Proteins; D009124:Muscle Proteins; C112246:NOL3 protein, human