title: Blockade of supraspinal 5-HT1A receptors potentiates the inhibitory effect of venlafaxine on wind-up activity in mononeuropathic rats.
abstract: In mononeuropathic rats submitted to a C-fiber reflex responses paradigm, repeated administration (five successive injections every half-life) of 10 mg/kg, s.c. of venlafaxine, but not of 2.5 mg/kg, s.c., a mixed monoamine reuptake inhibitor with preferential inhibitory activity in 5-HT reuptake, induced a progressive reduction of spinal wind-up. Repeated co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 i.c.v. (50 microg/injection) significantly increased the effect of venlafaxine s.c., indicating that venlafaxine-induced inhibition of spinal wind-up in mononeuropathic rats is potentiated by blockade of central 5-HT1A receptors.
authors.affiliation: E 9904 INSERM/UdA, Laboratory of Medical Pharmacology, Faculty of Medicine, University of Auvergne-1, Clermont-Ferrand, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Marchand
authors.forename: Teresa
authors.initials: T
authors.lastname: Pelissier
authors.forename: Alain
authors.initials: A
authors.lastname: Eschalier
authors.forename: Denis
authors.initials: D
authors.lastname: Ardid
authors.forename: Abdelkrim
authors.initials: A
authors.lastname: Alloui
authors.forename: Rubén
authors.initials: R
authors.lastname: Soto-Moyano
authors.forename: Mauricio
authors.initials: M
authors.lastname: Mondaca
authors.forename: Claudio
authors.initials: C
authors.lastname: Laurido
authors.forename: Luis
authors.initials: L
authors.lastname: Constandil
authors.forename: Alejandro
authors.initials: A
authors.lastname: Hernández
mesh_terms: D000818:Animals; D003511:Cyclohexanols / Q000494:pharmacology*; D008297:Male; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects; D010523:Peripheral Nervous System Diseases / Q000473:pathology*; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013116:Spinal Cord / Q000166:cytology* / Q000187:drug effects; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D010879:Piperazines; D011725:Pyridines; D044282:Receptor, Serotonin, 5-HT1A; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide