Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target.
Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1)--the one EBV antigen that is expressed in all EBV-associated malignancies--has long been thought to go undetected by the cell-mediated immune system. However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV-related cancers.
Münz
Christian
C
Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave., New York, NY 10021, USA. munzc@rockefeller.edu
D019309:Epstein-Barr Virus Nuclear Antigens / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D009369:Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D019309:Epstein-Barr Virus Nuclear Antigens; C417029:EBV-encoded nuclear antigen 1