title: Change in bispectral index during epileptiform electrical activity under sevoflurane anesthesia in a patient with epilepsy.
abstract: We observed abnormal fluctuation in Bispectral Index (BIS) caused by repeated alternations between two electroencephalographic (EEG) waveform patterns in a patient with a recent history of epileptic seizure under sevoflurane anesthesia. The repetitive development of the abnormal EEG changes (slow delta with or without spike) and the fluctuation in BIS disappeared almost immediately after administration of anticonvulsants. BIS may give useful information not only on the sedative-hypnotic state, but also on the development of and recovery from abnormal epileptiform EEG activity.
  
  
  CONCLUSIONS
  During epileptiform electroencephalographic activity (EEG), the Bispectral Index shows an abnormal fluctuation caused by repeated abrupt alterations between normal EEG and abnormal epileptiform EEG patterns.
authors.affiliation: *Surgical Centre, Graduate School of Medicine, and †Department of Anesthesiology and Pain Relief Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Mieko
authors.initials: M
authors.lastname: Chinzei
authors.forename: Shigehito
authors.initials: S
authors.lastname: Sawamura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Hayashida
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kitamura
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Tamai
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hanaoka
mesh_terms: D018685:Anesthetics, Inhalation / Q000494:pharmacology* / Q000627:therapeutic use; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods; D004827:Epilepsy / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane