[Pulmonary complications in haploidentical bone marrow transplantation].
To explore the occurrence patterns of pulmonary complications at different stages in haploidentical bone marrow transplantation, a series of clinical data as the onset time, etiology, management choices and prognosis in 18 patients with pulmonary disorders were summarized. The results showed that in 18 out of 70 patients after bone marrow transplantation occurred pulmonary complications which included pneumonia affected by bacteria (7 cases), fungus (5 cases) and cytomegalovirus (CMV, 4 cases), bronchiolitis obliterans organizing pneumonia (BOOP, 1 case), and idiopathic pneumonia syndrome (1 case), out of which 8 cases died. Fungal and CMV pneumonia occurred predominantly 2 to 3 months after transplantation, whereas bacterial pneumonia was observed in the duration of 3 to 12 months and 4 cases of them suffered from secondary fungal infections during treatment. BOOP and idiopathic pneumonia syndrome were diagnosed 12 months and 50 days after transplantation respectively.


CONCLUSIONS
pulmonary complications were commonly seen in haploidentcal bone marrow transplantation, and fungal pneumonia might be the main cause that needs intensive management.
Wang
Heng-Xiang
HX
Department of Hematology, General Hospital of Air Force, PLA, Beijing 100036, China.
Ji
Shu-Quan
SQ
Zhu
Ling
L
Xue
Mei
M
Chen
Hui-Ren
HR
Yan
Hong-Min
HM
Liu
Jing
J
Duan
Lian-Ning
LN
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D018549:Cryptogenic Organizing Pneumonia / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000209:etiology; D005260:Female; D006239:Haplotypes; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male