title: [Special morphological changes of pathologic cells in two cases of Waldenström's macroglobulinemia].
abstract: Waldenström's macroglobulinemia (WM) is one of malignant hematological disease on account of abnormal proliferation of B lymphocyte clone and the pathologic cells of WM possess ability to secrete monoclonal immunoglobulin M. In this study, the diagnosis and morphological characteristics of 2 patients with WM were analyzed. The results showed that a special kind of "foam cells" were found by cytochemical staining examinations in both cases, which displayed characteristics of lymphocytes, but neither monocyte-macrophage nor fatty cells. The periodic acid-Shiff's reaction (PAS) demonstrated strong positive, especially on the inclusion bodies in pathologic cell plasma while the acid phosphatase, and alpha-butanoic acetate esterase stainings, resulted both in negative. In conclusion, the cells found in the two cases reported may be described as gemmy ring-like lymphocyte in morphology, a special subtype of ring-like lymphocyte.
authors.affiliation: Department of Hematology, Tumor Center of Qilu Hospital, Shandong University, Jinan 250012, China. xlchen1999@yahoo.com
authors.forename: Xue-Liang
authors.initials: XL
authors.lastname: Chen
authors.forename: Fang-Lin
authors.initials: FL
authors.lastname: Li
authors.forename: Chuan-Li
authors.initials: CL
authors.lastname: Zhao
authors.forename: Dao-Zi
authors.initials: DZ
authors.lastname: Jiang
authors.forename: Ping
authors.initials: P
authors.lastname: Qin
authors.forename: Ying-Fu
authors.initials: YF
authors.lastname: Wang
authors.forename: Shu-Xin
authors.initials: SX
authors.lastname: Yan
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*