title: Increased susceptibility of beta7-integrin-deficient neonatal mice in the early stage of Cryptosporidium parvum infection.
abstract: Numerous inflammatory cells are recruited in response to Cryptosporidium parvum infection. These cells include interferon gamma-producing T lymphocytes, which are of major importance for the resolution of infection. Here, we show that beta7 integrin is not essential for the control of infection in mice but that beta7-deficient neonatal mice are more susceptible during the early stages of infection.
authors.affiliation: Laboratoire de Contrôle et Immunologie de Maladies à Protozoaires, Unité 86 BASE, INRA de Tours, 37380 Nouzilly, France.
authors.forename: Roselyne
authors.initials: R
authors.lastname: Mancassola
authors.forename: Sonia
authors.initials: S
authors.lastname: Lacroix-Lamandé
authors.forename: Mathieu
authors.initials: M
authors.lastname: Barrier
authors.forename: Muriel
authors.initials: M
authors.lastname: Naciri
authors.forename: Henri
authors.initials: H
authors.lastname: Salmon
authors.forename: Fabrice
authors.initials: F
authors.lastname: Laurent
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D003457:Cryptosporidiosis / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D016785:Cryptosporidium parvum / Q000472:pathogenicity*; D004198:Disease Susceptibility; D006801:Humans; D007082:Ileum / Q000276:immunology / Q000469:parasitology; D039641:Integrin beta Chains / Q000235:genetics* / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D039641:Integrin beta Chains; C091368:integrin beta7