Diabetes mellitus and prostate cancer risk among older men: population-based case-control study.
We investigate the relation between diabetes mellitus and risk of prostate cancer among older (age 65-79 years) men in a population-based case-control study of 407 incident histologically confirmed cases registered in the South Carolina Central Cancer Registry between 1999 and 2001 (70.6% response rate); controls were 393 men identified through the Health Care Financing Administration Medicare beneficiary file for South Carolina in 1999 (63.8% response rate). After adjusting for age, race, and prostate cancer screening in the past 5 years, a history of diabetes mellitus was associated with a reduced risk of prostate cancer (adjusted odds ratio (aOR)=0.64; 95% confidence interval (CI)=0.45, 0.91). The protective effect was stronger for those with complications associated with diabetes (aOR=0.61; 95% CI=0.42, 0.90) and for African-American men (aOR=0.36; 95% CI=0.21, 0.62). Additional research is needed to understand the biologic mechanisms by which diabetes may influence prostate cancer risk; genetic factors may play an important role in understanding this association.
Coker
A L
AL
University of Texas-Houston School of Public Health, 1200 Herman Pressler Drive, Houston, TX 77225, USA. acoker@sph.uth.tmc.edu
Sanderson
M
M
Zheng
W
W
Fadden
M K
MK
D001741:Black or African American; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics; D016021:Epidemiologic Studies; D006801:Humans; D015994:Incidence; D008297:Male; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control*; D012307:Risk Factors