Evaluation of immune responses in horses immunized using a killed Sarcocystis neurona vaccine.
Clinically normal horses developed cellular immunity to Sarcocystis neurona following IM vaccination with a commercial killed S. neurona vaccine, as indicated by the development of measurable anti-S. neurona IgG antibodies and additional intradermal skin testing. Large-scale independent assessments of the vaccine's performance and safety are in progress under field conditions. The next step in the evaluation of this vaccine would be to attempt experimental challenge after a reproducible reliable equine model of S. neurona encephalitis has been established that allows for reisolation of the pathogen after challenge.
Marsh
Antoinette E
AE
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Lakritz
Jeffrey
J
Johnson
Philip J
PJ
Miller
Margaret A
MA
Chiang
Yu-Wei
YW
Chu
Hsien-Jue
HJ
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D004660:Encephalitis / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D006734:Horse Diseases / Q000276:immunology / Q000517:prevention & control*; D006736:Horses; D007428:Intradermal Tests / Q000662:veterinary; D008297:Male; D016052:Protozoan Vaccines; D012522:Sarcocystis / Q000276:immunology*; D012523:Sarcocystosis / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome
D000913:Antibodies, Protozoan; D016052:Protozoan Vaccines