[Effects of blood substitutes of different pharmacological groups and the mode of their injection on the bloodflow of rats].
Central and peripheral bloodflow before and after intramuscular and intravenous injections of 0.9% NaCl (control groups, n=20) and perfluothane (n=20) in a dose of 5 ml/kg was studied in 40 Wistar rats. Dopplerographic study of the bloodflow was carried out on a diagnostic device Biomedical AU-5 (Italy). The study showed that intramuscular injections of both 0.9% NaCl and perfluothane did not lead to a significant increase of the bloodflow, but perfluothane caused a significantly greater increase of both arterial and venous bloodflow in the injection zone in comparison with the control. Intravenous injection of perfluothane increased significantly the systemic and local bloodflow in comparison with the baseline level and control, while total peripheral resistance was decreased.
Orlov
A A
AA
Karmen
N B
NB
Lezhneva
I E
IE
Maevskiĭ
E I
EI
Marinicheva
I G
IG
Ippolitov
V P
VP
Grigorian
A S
AS
Bezrukov
V M
VM
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000494:pharmacology; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000494:pharmacology; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D018608:Ultrasonography, Doppler
D001802:Blood Substitutes; D005466:Fluorocarbons; D012965:Sodium Chloride; C063334:perftoran