title: Takayasu's arteritis secondary to myelodysplasia as a predictor of poor outcome: two case reports.
abstract: We present two patients with myelodysplasia in association with Takayasu's arteritis (TA). In both patients intensive immunosuppressive treatment could not control the vascular inflammation. Subsequently both patients developed myelodysplasia, rapidly progressing to secondary acute myelogenous leukaemia. One patient had a peripheral blood stem cell transplant from a compatible sibling donor, but died of refractory leukaemia 5 months later. The other patient died of fungal sepsis. These are the first two patients reported to have TA associated with myelodysplasia/secondary leukaemia.
authors.affiliation: Department of Medicine II, Tübingen University Hospital, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Amberger
authors.forename: C
authors.initials: C
authors.lastname: Denzlinger
authors.forename: J
authors.initials: J
authors.lastname: Janzen
authors.forename: M
authors.initials: M
authors.lastname: Müller-Schimpfle
authors.forename: M
authors.initials: M
authors.lastname: Mohren
authors.forename: I
authors.initials: I
authors.lastname: Kötter
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009436:Neural Tube Defects / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D011379:Prognosis; D013625:Takayasu Arteritis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017211:Treatment Failure
chemical_list: D007166:Immunosuppressive Agents