title: Confirmation and dissection of QTL controlling resistance to malaria in mice.
abstract: We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F(2) populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.
authors.affiliation: International Livestock Research Institute, Nairobi, Kenya.
authors.forename: Maria
authors.initials: M
authors.lastname: Hernandez-Valladares
authors.forename: Jan
authors.initials: J
authors.lastname: Naessens
authors.forename: John P
authors.initials: JP
authors.lastname: Gibson
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Musoke
authors.forename: Sonal
authors.initials: S
authors.lastname: Nagda
authors.forename: Pascal
authors.initials: P
authors.lastname: Rihet
authors.forename: Onesmo K
authors.initials: OK
authors.lastname: Ole-MoiYoi
authors.forename: Fuad A
authors.initials: FA
authors.lastname: Iraqi
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D007113:Immunity, Innate; D008126:Lod Score; D008288:Malaria / Q000235:genetics* / Q000276:immunology / Q000469:parasitology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018895:Microsatellite Repeats; D010641:Phenotype; D016788:Plasmodium chabaudi / Q000472:pathogenicity*; D040641:Quantitative Trait Loci