title: A novel mixed-ligand antimycobacterial dimeric copper complex of ciprofloxacin and phenanthroline.
abstract: A novel mixed-ligand Cu(II) complex of ciprofloxacin (cfH) and phenanthroline, is found to crystallize as a dimeric moiety containing monocationic and dicationic species. Two such dimeric moieties are found in the same unit cell leading to a dicationic cluster. The higher negative redox potential for this cluster dampens its antimycobacterial activity against M. smegmatis.
authors.affiliation: Department of Chemistry, University of Pune, Pune 411007, India.
authors.forename: Dilip Kumar
authors.initials: DK
authors.lastname: Saha
authors.forename: Uday
authors.initials: U
authors.lastname: Sandbhor
authors.forename: K
authors.initials: K
authors.lastname: Shirisha
authors.forename: Subhash
authors.initials: S
authors.lastname: Padhye
authors.forename: Dileep
authors.initials: D
authors.lastname: Deobagkar
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Anson
authors.forename: Annie K
authors.initials: AK
authors.lastname: Powell
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002939:Ciprofloxacin / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D020102:Mycobacterium smegmatis / Q000187:drug effects / Q000254:growth & development; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008024:Ligands; D010618:Phenanthrolines; D002939:Ciprofloxacin; D003300:Copper