New insights into the role of Vif in HIV-1 replication.
HIV-1 and most of the other lentiviruses encode Vif (virion infectivity factor), an accessory protein that the virus requires to replicate in primary CD4+ T-cells and monocytes. The host cell factor with which Vif interacts was recently identified as APOBEC3G, a cytidine deaminase related to the RNA-editing enzymes. Identification of this key host protein has allowed for dramatic leaps in our understanding of how Vif functions. Vif prevents the encapsidation of APOBEC3G into HIV-1 virions during virus assembly. If not for Vif, the encapsidated APOBEC3G would damage the virus reverse transcripts, causing their degradation and closing the open reading frames of its genes.
Schröfelbauer
Bärbel
B
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Yu
Qin
Q
Landau
Nathaniel R
NR
D000071480:APOBEC-3G Deaminase; D000818:Animals; D002460:Cell Line; D003564:Cytidine Deaminase; D016346:Gene Products, vif / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D009700:Nucleoside Deaminases; D011506:Proteins / Q000378:metabolism; D012097:Repressor Proteins; D014779:Virus Replication; D054320:vif Gene Products, Human Immunodeficiency Virus
D016346:Gene Products, vif; D011506:Proteins; D012097:Repressor Proteins; D054320:vif Gene Products, Human Immunodeficiency Virus; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase