Variant MYST4-CBP gene fusion in a t(10;16) acute myeloid leukaemia.
We report a novel fusion of the MYST4 and CBP genes in an acute myeloid leukaemia (AML)-M4 patient exhibiting t(10;16)(q22;p13) and t(11;17)(q23;q21). The t(10;16)(q22;p13) resulted in a rearrangement, where MYST4-CBP and CBP-MYST4 chimaeric transcripts were products of in-frame fusions of MYST4 exon 17 to CBP exon 6 and CBP exon 4 to MYST4 exon 18 respectively. The potential resulting chimaeric proteins showed similarities with MYST3-CBP, MYST3-P300 and MYST3-NCOA2 putative fusion proteins found in other cases of AML.
Murati
Anne
A
Département d'Oncologie Moléculaire, Institut Paoli-Calmettes and JMR 599 Inserm, Marseille, France.
Adélaïde
José
J
Mozziconacci
Marie-Joëlle
MJ
Popovici
Cornel
C
Carbuccia
Nadine
N
Letessier
Anne
A
Birg
Françoise
F
Birnbaum
Daniel
D
Chaffanet
Max
M
D000208:Acute Disease; D019677:Artificial Gene Fusion; D002678:Chimera / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*