Structure and function of poly(A) binding proteins.
Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They are bound by two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus. PABPC functions in the initiation of translation and in the regulation of mRNA decay. In both functions, an interaction with the m7G cap at the 5' end of the message plays an important role. PABPN1 is involved in the synthesis of poly (A) tails, increasing the processivity of poly (A) polymerase and contributing to defining the length of a newly synthesized poly (A) tail.
Kühn
Uwe
U
Institut für Biochemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Stasse. 3, D-06120 Halle, Germany.
Wahle
Elmar
E
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D039122:Poly(A)-Binding Protein I / Q000502:physiology; D039103:Poly(A)-Binding Protein II / Q000502:physiology; D039102:Poly(A)-Binding Proteins / Q000737:chemistry* / Q000502:physiology*; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D013329:Structure-Activity Relationship; D013696:Temperature
D005656:Fungal Proteins; D039122:Poly(A)-Binding Protein I; D039103:Poly(A)-Binding Protein II; D039102:Poly(A)-Binding Proteins; D012333:RNA, Messenger