title: Infection-induced expansion of a MHC Class Ib-dependent intestinal intraepithelial gammadelta T cell subset.
abstract: Salmonella species invade the host via the intestinal epithelium. Hence, intestinal intraepithelial lymphocytes (iIELs) are potentially the first element of the immune system to encounter Salmonella during infection. In this study, we demonstrate, in a mouse model, the expansion of a CD8alphabeta(+)CD94(-)TCRgammadelta(+) T cell subset within the iIEL population in response to oral infection with virulent or avirulent Salmonella. This population can be detected 3 days following infection, represents up to 15% of the TCRgammadelta(+) iIELs, and is dependent on the MHC class Ib molecule T23 (Qa-1). Qa-1 is expressed by intestinal epithelial cells and thus accessible for iIEL recognition. Such cells may play a role in the early immune response to Salmonella.
authors.affiliation: Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Adrian
authors.initials: A
authors.lastname: Davies
authors.forename: Sergio
authors.initials: S
authors.lastname: Lopez-Briones
authors.forename: Helena
authors.initials: H
authors.lastname: Ong
authors.forename: Cynthia
authors.initials: C
authors.lastname: O'Neil-Marshall
authors.forename: François A
authors.initials: FA
authors.lastname: Lemonnier
authors.forename: Kanneboyina
authors.initials: K
authors.lastname: Nagaraju
authors.forename: Eleanor S
authors.initials: ES
authors.lastname: Metcalf
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Soloski
mesh_terms: D018528:ATP-Binding Cassette Transporters; D000818:Animals; D016827:CD8 Antigens / Q000032:analysis; D015395:Histocompatibility Antigens Class I / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000502:physiology; D007413:Intestinal Mucosa / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012486:Salmonella typhimurium / Q000254:growth & development; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D016827:CD8 Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; C032907:Q surface antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; C477327:transporter associated with antigen processing (TAP)