title: Optimized interleaved whole-brain 3D double inversion recovery (DIR) sequence for imaging the neocortex.
abstract: For a substantial number of individuals with neurological disorders, a conventional MRI scan does not reveal any obvious etiology; however, it is believed that abnormalities in the neocortical gray matter (GM) underlie many of these disorders. Attempts to image the neocortex are hindered by its thin, convoluted structure, and the partial volume (PV) effect. Therefore, we developed a 3D version of the double inversion recovery (DIR) sequence that incorporates an optimized interleaved (OIL) strategy to improve efficiency and allow high-quality, high-resolution imaging of GM.
authors.affiliation: Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK. p.boulby@ion.ucl.ac.uk
authors.forename: P A
authors.initials: PA
authors.lastname: Boulby
authors.forename: M R
authors.initials: MR
authors.lastname: Symms
authors.forename: G J
authors.initials: GJ
authors.lastname: Barker
mesh_terms: D001921:Brain / Q000473:pathology; D004827:Epilepsy / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019579:Neocortex / Q000473:pathology*