title: Relevance of homocysteine on brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness in patients with hypercholesterolemia.
abstract: The relevance of homocysteine to brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness was investigated in 192 patients with hypercholesterolemia. Low-density lipoprotein cholesterol and homocysteine levels predicted brachial flow-mediated vasodilatation, internal carotid mean intima-media thickness, and intima-media thickening at all femoral sites. Homocysteine levels seem to be an additional factor in the initial atherosclerotic damage of patients with hypercholesterolemia.
authors.affiliation: Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia School of Medicine, via Brunamonti 51, 06122 Perugia, Italy. gvaudo@unipg.it
authors.forename: Gaetano
authors.initials: G
authors.lastname: Vaudo
authors.forename: Simona
authors.initials: S
authors.lastname: Marchesi
authors.forename: Donatella
authors.initials: D
authors.lastname: Siepi
authors.forename: Francesco
authors.initials: F
authors.lastname: Bagaglia
authors.forename: Rita
authors.initials: R
authors.lastname: Paltriccia
authors.forename: Matteo
authors.initials: M
authors.lastname: Pirro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Schillaci
authors.forename: Graziana
authors.initials: G
authors.lastname: Lupattelli
authors.forename: Elmo
authors.initials: E
authors.lastname: Mannarino
mesh_terms: D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D012044:Regression Analysis; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*; D014463:Ultrasonography; D014664:Vasodilation / Q000502:physiology*
chemical_list: D008078:Cholesterol, LDL; D006710:Homocysteine