title: Antifungal potential of Indian medicinal plants.
abstract: Fourteen Indian plants, selected based on their use in respiratory and other disorders in traditional systems of medicine, were analyzed for their potential activity against fungi. The antifungal activity was investigated by disc diffusion, microbroth dilution and percent spore germination inhibition tests against pathogenic Aspergilli. Methanolic extracts of Solanum xanthocarpum and Datura metel inhibited the growth of Aspergillus fumigatus, A. flavus and A. niger and their in vitro MICs were found to be 1.25-2.50 mg/ml by both microbroth dilution and percent spore germination assays. In disc diffusion assay, a concentration of 0.062 mg/disc of methanol extract of D. metel showed significant activity against Aspergilli. S. xanthocarpum exhibited similar activity at 0.125 mg/disc.
authors.affiliation: Institute of Genomics and Integrative Biology, University Campus, Mall Road, Delhi 110007, India.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Dabur
authors.forename: H
authors.initials: H
authors.lastname: Singh
authors.forename: A K
authors.initials: AK
authors.lastname: Chhillar
authors.forename: M
authors.initials: M
authors.lastname: Ali
authors.forename: G L
authors.initials: GL
authors.lastname: Sharma
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001230:Aspergillus / Q000187:drug effects*; D032302:Datura; D006801:Humans; D007194:India; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D032322:Solanum
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts