Potential therapeutic targets for neurokinin-1 receptor antagonists.
The peptide substance P and its tachykinin receptor, neurokinin-1 (NK1), have been the focus of considerable research for their role in a variety of both central and peripheral diseases. Recent preclinical data, as well as relevant clinical findings, support the potential therapeutic value of NK1 receptor antagonists in centrally mediated disease states, including anxiety and depression. In addition, a separate body of literature supports the use of NK1 receptor antagonists as inhibitors of centrally mediated emetic and cough responses. The role of NK1 receptor antagonists as analgesic agents with potential to treat migraine headache has also been investigated. NK1 receptors are also found in a number of peripheral regions, including the bladder, gastrointestinal tract and bone marrow. Preclinical models have been employed to address the potential therapeutic uses for NK1 receptor antagonists in diseases associated with inflammatory responses, including asthma, irritable bowel syndrome and cystitis of the bladder. Finally, other more recent publications suggest a role for NK1 receptor antagonists as tumour suppressants and haematopoietic agents. These applications for NK1 receptor antagonists are discussed in this review.
Duffy
Ruth A
RA
Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. ruth.duffy@spcorp.com
D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D018927:Anti-Asthmatic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D000932:Antiemetics / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D000996:Antitussive Agents / Q000494:pharmacology / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003371:Cough / Q000188:drug therapy; D003556:Cystitis / Q000188:drug therapy; D003863:Depression / Q000188:drug therapy; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D043183:Irritable Bowel Syndrome / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D064729:Neurokinin-1 Receptor Antagonists; D010146:Pain / Q000188:drug therapy; D013373:Substance P / Q000037:antagonists & inhibitors / Q000502:physiology; D014839:Vomiting / Q000188:drug therapy
D000700:Analgesics; D014151:Anti-Anxiety Agents; D018927:Anti-Asthmatic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents; D000932:Antiemetics; D000970:Antineoplastic Agents; D000996:Antitussive Agents; D064729:Neurokinin-1 Receptor Antagonists; D013373:Substance P