title: Chronic myeloid leukemia in an adolescent with Ollier's disease after intensive X-ray exposure.
abstract: We report a 19-year-old man with Ollier's disease with multiple orthopedic procedures performed for leg length discrepancy; who developed chronic myeloid leukemia presenting with intramuscular hematoma. His symptoms resolved with cytoreductive treatment by hydroxyurea. Cytogenetic and molecular investigations showed a complex Philadelphia translocation t(9;22;13) (q34;q11.2;q12), with predominance of ela2 BCR/ABL splicing and deletion of reciprocal der(9) ABL/BCR locus, all suggesting poor prognosis. The cumulative X-ray exposure from repeated operations from the age of 7 to 12 years was estimated to be around 16 mSv, approximately the dose of 720 chest X rays. Literature review showed two other cases of leukemia occurring in patients with multiple enchondromatosis. Although the development of CML in this young patient might be related partly to genetic defects, the repeated radiation exposure, especially at young age and directly on the marrow tissue in the long bones, might also be an important pathogenetic factor.
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong, SAR, China. auwing@hotmail.com
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: G C
authors.initials: GC
authors.lastname: Ooi
authors.forename: S K
authors.initials: SK
authors.lastname: Ma
authors.forename: T S K
authors.initials: TS
authors.lastname: Wan
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004687:Enchondromatosis / Q000150:complications* / Q000000981:diagnostic imaging* / Q000601:surgery; D006406:Hematoma; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000209:etiology*; D008297:Male; D009154:Mutation; D011829:Radiation Dosage; D011859:Radiography; D014965:X-Rays / Q000009:adverse effects*