title: Efficiency of flow-driven adiabatic spin inversion under realistic experimental conditions: a computer simulation.
abstract: Continuous arterial spin labeling (CASL) using adiabatic inversion is a widely used approach for perfusion imaging. For the quantification of perfusion, a reliable determination of the labeling efficiency is required. A numerical method for predicting the labeling efficiency in CASL experiments under various experimental conditions, including spin relaxation, is demonstrated. The approach is especially useful in the case of labeling at the carotid artery with a surface coil, as consideration of the experimental or theoretical profile of the B(1) field is straightforward. Other effects that are also accounted for include deviations from a constant labeling gradient, and variations in the blood flow velocity due to the cardiac cycle. Assuming relevant experimental and physiological conditions, maximum inversion efficiencies of about 85% can be obtained.
authors.affiliation: Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany. trampel@cns.mpg.de
authors.forename: Robert
authors.initials: R
authors.lastname: Trampel
authors.forename: Thies H
authors.initials: TH
authors.lastname: Jochimsen
authors.forename: Toralf
authors.initials: T
authors.lastname: Mildner
authors.forename: David G
authors.initials: DG
authors.lastname: Norris
authors.forename: Harald E
authors.initials: HE
authors.lastname: Möller
mesh_terms: D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000502:physiology*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D018810:Magnetic Resonance Angiography / Q000379:methods; D008955:Models, Cardiovascular; D009200:Myocardial Contraction