Assessment of myocardial perfusion and fatty acid metabolism in a patient with Churg-Strauss syndrome associated with eosinophilic heart disease.
Churg-Strauss syndrome is characterized by asthma, eosinophilia and systemic necrotizing vasculitis; cardiac involvement (ie, eosinophilic heart disease) is the major cause of morbidity and mortality, although there are no reports of an association between left ventricular dysfunction because of eosinophilic heart disease and myocardial blood flow or myocardial fatty acid metabolism. A patient presented with Churg-Strauss syndrome associated with eosinophilic heart disease that had progressed to dilated cardiomyopathy. Coronary angiography, thallium-201 ((201)Tl) and iodine-123 beta-methyl-iodophenyl pentadecanoic acid ((123)I BMIPP) myocardial single photon emission computed tomography (SPECT) were performed to evaluate left ventricular dysfunction. Although coronary angiography was normal and (201)Tl SPECT showed no apparent image defect, (123)I BMIPP SPECT showed diffuse decreased accumulation, excepting the apex. The left ventricular dysfunction in patients with eosinophilic heart disease is associated with impaired myocardial fatty acid metabolism rather than with impaired myocardial blood flow.
Shikama
Nobuaki
N
Department of Internal Medicine, Chiba Municipal Hospital, Japan. ichi-hs@atlas.plala.or.jp
Nakagawa
Tomoo
T
Takiguchi
Yasuo
Y
Aotsuka
Nobuyuki
N
Kuwabara
Yoichi
Y
Komiyama
Nobuyuki
N
Terano
Takashi
T
Hirai
Akira
A
D000368:Aged; D002311:Cardiomyopathy, Dilated; D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D003326:Coronary Circulation; D018450:Disease Progression; D004452:Echocardiography; D004562:Electrocardiography; D004802:Eosinophilia; D005227:Fatty Acids / Q000378:metabolism*; D006331:Heart Diseases / Q000097:blood / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon
D005227:Fatty Acids