[Effect of fixed low dose combination of perindopril and indapamide on processes of cardiovascular remodeling in previously untreated patients with hypertension].
OBJECTIVE
To assess changes of blood pressure (BP) and processes of cardiovascular remodeling during treatment of previously untreated patients with hypertension with fixed low dose combination of perindopril and indapamide.


METHODS
Patients with untreated hypertension (n=30, mean age 46.7+/-1.8 years, 16 men, 14 women) received low-dose perindopril (2 mg) - indapamide (0.625 mg) combination for 6 months.


METHODS
Twenty four-hour BP monitoring, measurement of left ventricular (LV) mass index and wall and interventricular septal thickness, carotid artery intima-media thickness, pulse wave velocity and cerebral blood flow velocity.


RESULTS
Target BP level was reached in 83.3% of patients. BP monitoring revealed significant lowering of daytime and nocturnal systolic BP (-13.2%, p<0.0001 and -14.5%, p<0.0001, respectively), daytime and nocturnal diastolic BP (- 14.3%, p<0.0001 and -15.3%, p<0.0001, respectively). Significant reduction of LV mass index (-12%, p=0.0002) was also observed. Both LV posterior wall and interventricular septal thicknesses were reduced as well (-5.1%, p<0,01). This was accompanied by decreases of intima-media thickness of right and left carotid arteries (-5,4%, p=0.04 and -5,3%, p=0.01, respectively), reduction of stiffness of elastic arteries (carotid-femoral pulse wave velocity decreased by 8%, p=0.003), and increase of cerebral blood flow velocity.


CONCLUSIONS
The use of perindopril/indapamide combination in hypertensive patients was associated BP lowering and positive effects on remodeling both of the heart and large and medium arteries.
Lopatin
Iu M
IuM
Volgograd State Medical University, Volgograd Region Cardiology Center, Russia.
Ivanenko
V V
VV
Semenova
N V
NV
Riazantseva
N V
NV
Legkiĭ
A V
AV
Anisimova
L P
LP
D000959:Antihypertensive Agents / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D059168:Carotid Intima-Media Thickness; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007190:Indapamide / Q000008:administration & dosage; D020913:Perindopril / Q000008:administration & dosage; D063177:Pulse Wave Analysis
D000959:Antihypertensive Agents; D007190:Indapamide; D020913:Perindopril