Three children with CD30 cutaneous anaplastic large cell lymphomas bearing the t(2;5)(p23;q35) translocation.
Since its discovery in CD30(+) anaplastic large cell lymphomas, the t(2;5)(p23;q35) translocation has shown a high degree of association with nodal disease, younger patient age, and better prognosis. Furthermore, primary cutaneous CD30(+) anaplastic large cell lymphomas rarely manifests the t(2;5) translocation. We present three cases of this disease that occurred in children, bore the t(2;5) translocation, and had excellent outcomes, but presented cutaneously. Two of these lesions were primary skin lymphomas. Review of the available literature in conjunction with these three cases suggests that the t(2;5) translocation may be more strongly associated with younger patient age and favorable outcomes rather than nodal versus cutaneous site of presentation.
Hinshaw
Molly
M
Department of Dermatology, University of Wisconsin-Madison and VA Medical Center Madison, Wisconsin, USA.
Trowers
Andrea B
AB
Kodish
Eric
E
Kuerbitz
Steven
S
Shurin
Susan
S
Wood
Gary S
GS
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D017730:Ki-1 Antigen