title: phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development.
abstract: Proneural basic helix-loop-helix (bHLH) proteins initiate neurogenesis in both vertebrates and invertebrates. The Drosophila Achaete (Ac) and Scute (Sc) proteins are among the first identified members of the large bHLH proneural protein family. phyllopod (phyl), encoding an ubiquitin ligase adaptor, is required for ac- and sc-dependent external sensory (ES) organ development. Expression of phyl is directly activated by Ac and Sc. Forced expression of phyl rescues ES organ formation in ac and sc double mutants. phyl and senseless, encoding a Zn-finger transcriptional factor, depend on each other in ES organ development. Our results provide the first example that bHLH proneural proteins promote neurogenesis through regulation of protein degradation.
authors.affiliation: Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan.
authors.forename: Haiwei
authors.initials: H
authors.lastname: Pi
authors.forename: Shao-Kuei
authors.initials: SK
authors.lastname: Huang
authors.forename: Chiou-Yang
authors.initials: CY
authors.lastname: Tang
authors.forename: Y Henry
authors.initials: YH
authors.lastname: Sun
authors.forename: Cheng-Ting
authors.initials: CT
authors.lastname: Chien
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000196:embryology* / Q000235:genetics; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs; D009024:Morphogenesis / Q000502:physiology; D009154:Mutation; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D017956:Photoreceptor Cells, Invertebrate / Q000033:anatomy & histology / Q000196:embryology / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D019076:Transgenes
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D011993:Recombinant Fusion Proteins; D014157:Transcription Factors; C089199:ac protein, Drosophila; C092070:phyl protein, Drosophila; C089197:sc protein, Drosophila; C413162:sens protein, Drosophila