Refinement of a locus for Marie Unna hereditary hypotrichosis to a 1.1-cM interval at 8p21.3.
BACKGROUND
Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal congenital alopecia with progressive hair loss starting in early childhood and accelerating at puberty. A locus for MUHH has been mapped on chromosome 8p21 but no genes for MUHH have been identified to date.


OBJECTIVE
To refine the MUHH locus to a narrow chromosome region to facilitate cloning of the gene.


METHODS
We performed genotyping and linkage analysis in a multigeneration Chinese family with MUHH, using 18 high-density microsatellite markers spanning the previously mapped interval at 8p21.


RESULTS
Significant evidence for linkage was observed in this region, with a maximum two-point LOD score of 3.01 (theta = 0). Haplotype analysis localized the MUHH locus within the region defined by D8S282 and D8S1839. This region overlaps by 1.1-cM with the previously reported MUHH region and represents a physical distance of about 380 kb.


CONCLUSIONS
This study provides a refined map location (1.1 cM) for isolation of the gene causing MUHH. These data also indicate the existence of a common MUHH locus at 8p21.3 between affected caucasian and Chinese families.
He
P P
PP
Institute of Dermatology and Department of Dermatology at No. 1 Hospital, Anhui Medical University, and Key Laboratory of Genome Research at Anhui, 69 Meishan Road, Hefei, 230032 Anhui, China.
Zhang
X J
XJ
Yang
Q
Q
Li
M
M
Liang
Y H
YH
Yang
S
S
Yan
K L
KL
Cui
Y
Y
Shen
Y Y
YY
Wang
H Y
HY
Sun
L D
LD
Du
W H
WH
Shen
Y J
YJ
Xu
S J
SJ
Huang
W
W
D000368:Aged; D000505:Alopecia / Q000235:genetics / Q000473:pathology; D002648:Child; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004252:DNA Mutational Analysis; D018450:Disease Progression; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007039:Hypotrichosis / Q000151:congenital / Q000235:genetics* / Q000473:pathology; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010375:Pedigree