title: Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis.
abstract: Anti-ryanodine receptor (RyR) antibodies were measured in sera from 33 myasthenia gravis (MG) patients using three peptides from the human RyR1 sequence, two C-terminal peptides included in the functional calcium release channel, and an N-terminal peptide implicated in ion-conduction. Antibodies were more frequently positive against the two C-terminal peptides, particularly in thymoma-associated MG. In a preliminary open trial with FK506, immunosuppressant and enhancer of RyR-related sarcoplasmic calcium release, the authors observed the sustained benefits in anti-RyR-positive MG patients.
authors.affiliation: Neurological Center, Kanazawa-Nishi Hospital, Kanazawa, Japan. t-kiyomi@guitar.ocn.ne.jp
authors.forename: M
authors.initials: M
authors.lastname: Takamori
authors.forename: M
authors.initials: M
authors.lastname: Motomura
authors.forename: N
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nemoto
authors.forename: T
authors.initials: T
authors.lastname: Hattori
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: K
authors.initials: K
authors.lastname: Otsuka
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology*; D003131:Combined Modality Therapy; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology / Q000601:surgery; D011950:Receptors, Cholinergic / Q000276:immunology; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry / Q000276:immunology*; D016559:Tacrolimus / Q000627:therapeutic use*; D013934:Thymectomy; D013945:Thymoma / Q000150:complications / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D000939:Epitopes; D007166:Immunosuppressive Agents; D011950:Receptors, Cholinergic; D019837:Ryanodine Receptor Calcium Release Channel; D016559:Tacrolimus