[Study of NMDAR expression in hippocampal CA(1) region in neonatal rats with hypoxic-ischemia].
OBJECTIVE
To study the expressions of NMDAR in hippocampal CA(1) region after hypoxic-ischemic brain damage(HIBD) in neonatal rats.


METHODS
An neonatal rat model with hypoxic-ischemic brain damage was set up. The expression of NMDAR was detected in normal control and hypoxic-ischemic (HI) brain damage group by immunohistochemical staining and in situs hybridization.


RESULTS
The number of NR1(+) and NR1 mRNA(+) cells decreased slightly in hippocampal CA(1) region at 2 h after HI. The numbers increased from 24 h to 48 h after HI, and reached maximum at 72 h after HI.


CONCLUSIONS
NR1 expressed in hippocampal CA(1) region of normal neonatal rats, and the expression is up-regulated after HI brain injury.
Cao
Yan-Hua
YH
Department of Pediatrics, Tangdu Hospital,Fourth Military Medical University, Xi'an 710038,China.
Wang
Ling
L
Cao
Yu-Hong
YH
Wang
Bao-Xi
BX
Yu
Sui-He
SH
D000818:Animals; D000831:Animals, Newborn; D056547:CA1 Region, Hippocampal / Q000378:metabolism; D020925:Hypoxia-Ischemia, Brain; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism
D016194:Receptors, N-Methyl-D-Aspartate