Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors.
Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D(3). These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC(50)=0.44-0.89 microM).
Shimazawa
Rumiko
R
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Suzuki
Toshiyuki
T
Dodo
Kosuke
K
Shirai
Ryuichi
R
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D002762:Cholecalciferol; C517004:CDC25A protein, human; D020687:cdc25 Phosphatases; C121906:dysidiolide; D015107:4-Butyrolactone