Adiponectin but not resistin is associated with insulin resistance-related phenotypes in baboons.
OBJECTIVE
The hormones adiponectin and resistin have been associated with insulin resistance. This paper analyzed the potential relationship between adiponectin and resistin and insulin resistance-related phenotypes in baboons.


METHODS
One hundred eight adult baboons (84 female and 24 male) were studied. Weight was measured, and a blood sample was collected under fasting conditions for plasma and monocyte isolation. Fasting glucose, insulin, C-peptide, and adiponectin levels in plasma were measured by standard methods. Insulin resistance was calculated by the homeostasis model assessment index. Resistin mRNA abundance in monocytes was determined by real-time quantitative reverse transcription-polymerase chain reaction. Data were clustered by weight tertiles for statistical analysis.


RESULTS
As observed in humans, the insulin resistance-related phenotypes were related to weight, plasma levels of adiponectin, and C-peptide. No significant relationship between resistin circulating levels or expression in monocytes and insulin resistance-related phenotypes was found in baboons.


CONCLUSIONS
These findings suggest that resistin is not associated with insulin resistance. However, previous observations of relationships among weight, adiponectin, and insulin resistance are confirmed.
Tejero
M Elizabeth
ME
Division of Nutritional Sciences, University of Texas, Austin, USA.
Freeland-Graves
Jeanne H
JH
Proffitt
J Michael
JM
Peebles
Kyle W
KW
Cai
Guowen
G
Cole
Shelley A
SA
Comuzzie
Anthony G
AG
D052242:Adiponectin; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D005215:Fasting; D005260:Female; D015870:Gene Expression; D006706:Homeostasis; D006729:Hormones, Ectopic / Q000097:blood* / Q000235:genetics; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009000:Monocytes / Q000737:chemistry; D010215:Papio / Q000097:blood*; D010641:Phenotype; D011506:Proteins / Q000032:analysis*; D012333:RNA, Messenger / Q000097:blood; D052243:Resistin; D020133:Reverse Transcriptase Polymerase Chain Reaction
D052242:Adiponectin; D001786:Blood Glucose; D002096:C-Peptide; D006729:Hormones, Ectopic; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger; D052243:Resistin