title: Primitive neuroectodermal tumor (PNET) treated with interferon-beta after surgical removal and irradiation: case report.
abstract: This case report describes an 11-year-old boy with primitive neuroectodermal tumor (PNET), which remains the pediatric brain tumor with the worst prognosis despite combination treatment with surgery, irradiation and anti-cancer drugs. The boy was successfully treated with intratumoral administration of interferon-beta (IFN-beta) following surgical resection and irradiation. Two million units of IFN-beta were locally administered into the post-operative cavity through the Ommaya's reservoir every two weeks after discharge. He was managed as an outpatient without serious side-effects to IFN. The patient has shown no tumor recurrence, mental retardation, or neuroendocrine impairment for over three years and has lived a normal school life with a full Karnofsky Performance Status score. The local administration of IFN-beta may be warranted for maintenance therapy in children with PNET.
authors.affiliation: Department of Neurosurgery, Kochi Medical School, Kohasu, Nankoku-shi, Kochi 783-8505 Japan. park@kochi-ms.ac.jp
authors.forename: Kae Chang
authors.initials: KC
authors.lastname: Park
authors.forename: Shinichi
authors.initials: S
authors.lastname: Toyonaga
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Nakabayashi
authors.forename: Hikaru
authors.initials: H
authors.lastname: Mizobuchi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakai
authors.forename: Naoki
authors.initials: N
authors.lastname: Ikawa
authors.forename: Keiji
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D002408:Catheters, Indwelling; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage*; D018242:Neuroectodermal Tumors, Primitive / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D016899:Interferon-beta