Epithelioid malignant peripheral nerve sheath tumour in a dog.
An unusual morphological variant of malignant peripheral nerve sheath tumour, in which the cells exhibited a predominantly epithelial morphology, was diagnosed in a dog. The animal had a history of progressive ataxia. Post-mortem examination revealed an infiltrative growth in the sublumbar region, encroaching on the L1 and L2 vertebral bodies; additional masses were observed in the kidneys, liver and lungs. Histologically, the subcutaneous mass was composed of a dense population of spindle-shaped cells arranged in fascicles. The internal masses were composed of epithelioid cells arranged in a nodular pattern. Immunohistochemically, the spindle-shaped cells of the subcutaneous mass were positive for S-100, and the epithelioid cells of the internal growths exhibited weak S-100 immunoreactivity.
García
P
P
Department of Animal Pathology II, Veterinary School, Universidad Complutense de Madrid, Madrid E-28040, Spain.
Sánchez
B
B
Sánchez
M A
MA
González
M
M
Rollán
E
E
Flores
J M
JM
D000818:Animals; D003937:Diagnosis, Differential; D004285:Dogs; D015622:Epithelioid Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D007150:Immunohistochemistry; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000662:veterinary*