title: Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents.
abstract: Two new generation carbon dioxide absorbents, DrägerSorb Free and Amsorb Plus, were studied in vitro for formation of compound A or carbon monoxide, during minimal gas flow (500 ml x min(-1)) with sevoflurane or desflurane. Compound A was assessed by gas chromatography/mass spectrometry and carbon monoxide with continuous infrared spectrometry. Fresh and dehydrated absorbents were studied. Mean (SD) time till exhaustion (inspiratory carbon dioxide concentration >or= 1 kPa) with fresh absorbents was longer with DrägerSorb Free (1233 (55) min) than with Amsorb Plus (1025 (55) min; p < 0.01). For both absorbents, values of compound A were < 1 ppm and therefore below clinically significant levels, but were up to 0.25 ppm higher with DrägerSorb Free than with Amsorb Plus. Using dehydrated absorbents, values of compound A were about 50% lower than with fresh absorbents and were identical for DrägerSorb Free and Amsorb Plus. With dehydrated absorbents, no detectable carbon monoxide was found with desflurane.
authors.affiliation: Department of Anaesthesia, Ghent University Hospital, Ghent, Belgium. michel.struys@ugent.be
authors.forename: M M R F
authors.initials: MM
authors.lastname: Struys
authors.forename: M P L A
authors.initials: MP
authors.lastname: Bouche
authors.forename: G
authors.initials: G
authors.lastname: Rolly
authors.forename: Y D I
authors.initials: YD
authors.lastname: Vandevivere
authors.forename: D
authors.initials: D
authors.lastname: Dyzers
authors.forename: W
authors.initials: W
authors.lastname: Goeteyn
authors.forename: L F M
authors.initials: LF
authors.lastname: Versichelen
authors.forename: J F P
authors.initials: JF
authors.lastname: Van Bocxlaer
authors.forename: E P
authors.initials: EP
authors.lastname: Mortier
mesh_terms: D000042:Absorption; D000764:Anesthesia, Closed-Circuit / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000737:chemistry; D002122:Calcium Chloride; D002126:Calcium Hydroxide; D002245:Carbon Dioxide / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry*; D000077335:Desflurane; D004987:Ethers / Q000737:chemistry*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000737:chemistry; D008738:Methyl Ethers / Q000737:chemistry; D000077149:Sevoflurane; D013696:Temperature
chemical_list: C400293:Amsorb; D018685:Anesthetics, Inhalation; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; C078742:fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether; D002248:Carbon Monoxide; D000077335:Desflurane; D007530:Isoflurane; D002122:Calcium Chloride; D002126:Calcium Hydroxide