title: [Two cases of recurrent gastric cancer at anastomosis medicated by TS-1].
abstract: Two cases of recurrent gastric cancer are described. Recurrence at anastomosis was detected following total gastrectomy in both patients. They declined surgery but wanted medical treatment. Therefore, 100 mg/kg of TS-1 was administered with informed consent. Symptoms related to stenosis were relieved after the first course, and complete responses were confirmed by endoscopic and pathological studies after completion of 4 courses in both patients. Palliative surgery remains a major option of treatments for patients with recurrence at anastomosis after total gastrectomy. TS-1, however, should be considered a treatment for such cases with satisfactory QOL, especially for outpatients who do not want surgery.
authors.affiliation: Aomori City Hospital.
authors.forename: Hajime
authors.initials: H
authors.lastname: Morohashi
authors.forename: Itaru
authors.initials: I
authors.lastname: Shibazaki
authors.forename: Toshihito
authors.initials: T
authors.lastname: Mitsui
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Murata
authors.forename: Shunji
authors.initials: S
authors.lastname: Aizawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hashizume
authors.forename: Masaaki
authors.initials: M
authors.lastname: Endo
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Nishizawa
mesh_terms: D000368:Aged; D000713:Anastomosis, Roux-en-Y; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D004338:Drug Combinations; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010094:Oxonic Acid / Q000627:therapeutic use*; D010166:Palliative Care; D011725:Pyridines / Q000627:therapeutic use*; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid