title: Case-control study of anaplastic thyroid cancer.
abstract: OBJECTIVE
  The aim of the present study was to test some hypothetical risk factors for anaplastic thyroid cancer.
  
  
  METHODS
  A case-control study comprised 110 patients with histologically or cytologically verified anaplastic thyroid cancer and 110 hospital controls individually matched with cases by sex, age, place of residence and time of hospitalization. Univariate and multivariate logistic regressions were used for data analysis.
  
  
  RESULTS
  According to the conditional logistic regression analysis, the following factors were significantly and independently related to anaplastic thyroid cancer: history of goiter or thyroid nodules (odds ratio, OR, 37.55; 95% confidence interval, CI, 4.86-290.11), history of residence in endemic goiter area (OR, 2.56; 95% CI, 1.05-6.22), history of previous malignant non-thyroid tumor (OR, 5.51; 95% CI, 1.04-29.25), diabetes mellitus (OR, 4.06; 95% CI, 1.29-12.81) and low educational level (OR, 2.44; 95% CI, 1.17-5.06).
  
  
  CONCLUSIONS
  The results are in line with the current knowledge on factors related to thyroid cancer, except for the association between thyroid cancer and diabetes mellitus, which as far as we know has not yet been reported.
authors.affiliation: Center for Endocrine Surgery, Institute of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia and Montenegro. abvzival@Eunet.Yu
authors.forename: Vladan
authors.initials: V
authors.lastname: Zivaljevic
authors.forename: Hristina
authors.initials: H
authors.lastname: Vlajinac
authors.forename: Radovan
authors.initials: R
authors.lastname: Jankovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Marinkovic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Diklic
authors.forename: Ivan
authors.initials: I
authors.lastname: Paunovic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D002277:Carcinoma / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D048909:Diabetes Complications; D005260:Female; D006043:Goiter, Endemic / Q000150:complications / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D016017:Odds Ratio; D018570:Risk Assessment; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015022:Yugoslavia / Q000453:epidemiology