title: Use of artificial dermis and recombinant basic fibroblast growth factor for creating a neovagina in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome.
abstract: Vaginal agenesis is an uncommon, but not rare, condition. Although there are many methods for creating a neovagina, the optimal treatment is unknown. An 18-year-old woman with Mayer-Rokitansky-Küster-Hauser syndrome received vaginoplasty with a modified Wharton procedure using an artificial dermis (atelocollagen sponge). From 10 days after the operation, the patient was administered human recombinant basic fibroblast growth factor (bFGF) spray to accelerate epithelialization on the neovagina. At 50 days after the operation, we confirmed histological squamous epithelialization of the vaginal epithelium. At 12 months after the operation, the neovagina was at least 3.5 cm in width and approximately 8 cm in length. In this case, use of artificial dermis and recombinant bFGF to create a neovagina was an easy, less invasive and useful method.
authors.affiliation: Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama-city, 700-8558, Japan. soichi@d2.dion.ne.jp
authors.forename: Soichi
authors.initials: S
authors.lastname: Noguchi
authors.forename: Mikiya
authors.initials: M
authors.lastname: Nakatsuka
authors.forename: Yuka
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Chebib
authors.initials: C
authors.lastname: Chekir
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Kamada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hiramatsu
mesh_terms: D000015:Abnormalities, Multiple; D000282:Administration, Intravaginal; D000293:Adolescent; D000336:Aerosols; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000627:therapeutic use*; D005836:Genitalia, Female / Q000002:abnormalities*; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D017768:Skin, Artificial; D019738:Surgically-Created Structures; D013577:Syndrome; D016896:Treatment Outcome; D014621:Vagina / Q000002:abnormalities* / Q000601:surgery*
chemical_list: D000336:Aerosols; D011994:Recombinant Proteins; D016222:Fibroblast Growth Factor 2