[Therapeutic targets in diabetic vasculopathy].
Vascular complications are the main cause of morbidity and mortality in long-term diabetes mellitus. Endothelial dysfunction appears as an initial pathological mechanism leading to diabetic vasculopathy, which is associated with sustained high glucose levels and enhanced oxidative stress. Non-enzymatic protein glycosylation, through the formation of so-called advanced glycosylation end-products, appears as one of the mechanisms involved in diabetes-associated endothelial dysfunction. Our research group further proposes that early and intermediate glycosylation products (Amadori products), which are able to release reactive oxygen species, can also play a relevant role in the development of diabetic vasculopathy.
Sánchez Ferrer
Carlos Félix
CF
D000818:Animals; D048909:Diabetes Complications; D003925:Diabetic Angiopathies / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D005609:Free Radicals; D017127:Glycation End Products, Advanced / Q000502:physiology; D006031:Glycosylation; D006801:Humans
D005609:Free Radicals; D017127:Glycation End Products, Advanced