title: Inflammation and coronary calcification in renal patients--factors that may explain increased cardiovascular risk, and poorer results of coronary interventions?
abstract: Cardiovascular disease (CVD) is one of the major causes of mortality in patients with renal diseases, with increased odds ratio of mortality with risk factors as diverse as cholesterol, vascular stiffness, chronic inflammation and hyperhomocysteinemia. Several factors have been incriminated to explain the increase in coronary vascular calcification (CVC) in this particular population. Increased duration of dialysis, dyslipidemia, altered calcium-phosphorus metabolism, and chronic inflammation have all been associated with increased CVC. We present here four case reports illustrating the differences in the pathophysiology, therapy and prognosis of calcific coronary heart disease seen in uremic patients.
authors.affiliation: Department of Nephrology and Transplantation, Guy's and St Thomas' Hospital, London, UK.
authors.forename: Ophelia
authors.initials: O
authors.lastname: Dadzie
authors.forename: Nabil Ma
authors.initials: NM
authors.lastname: Hujairi
authors.forename: Cliff
authors.initials: C
authors.lastname: Bucknall
authors.forename: Simon
authors.initials: S
authors.lastname: Redwood
authors.forename: Michael
authors.initials: M
authors.lastname: Rubens
authors.forename: David
authors.initials: D
authors.lastname: Goldsmith
mesh_terms: D000328:Adult; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007249:Inflammation; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors