title: Pulmonary thromboembolism. Evaluating the indication and effect of a vena caval filter with indium-111-platelet scintigraphy.
abstract: A 63-year-old woman complained of chest pain and was referred to hospital where she was found to have left pleural effusion and swelling, local heat and edema of the right lower leg. Initial pulmonary perfusion scintigraphy demonstrated multiple defects and pulmonary thromboembolism (PTE) was confirmed during the anticoagulant and thrombolytic therapy against thrombophlebitis. A Greenfield filter was inserted in the inferior vena cava to prevent recurrence of PTE from the thrombosis that was resistant to therapy. In-111-labeled platelet scintigraphy (platelet scintigraphy) showed abnormal uptake of platelets in the chest, femoral veins and abdomen, which suggested active thrombus formation in those regions, including the filter, and a risk of recurrent PTE. Therefore, the thrombolytic therapy was terminated and the anticoagulant therapy intensified. A computed tomography (CT) scan revealed thrombus at the filter, which was markedly decreased 1 month later on platelet scintigraphy. Pulmonary ventilation and perfusion scintigraphy revealed remarkable improvement of the PTE. In this case, platelet scintigraphy complemented CT in demonstrating the activity and localization of the thrombus and can be used to evaluate the risk of recurrence during thrombolytic therapy after insertion of a filter.
authors.affiliation: Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yagi
authors.forename: Noboru
authors.initials: N
authors.lastname: Oriuchi
authors.forename: Noriko
authors.initials: N
authors.lastname: Sato
authors.forename: Jun
authors.initials: J
authors.lastname: Aoki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
mesh_terms: D001792:Blood Platelets / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy*; D011877:Radionuclide Imaging; D055502:Secondary Prevention; D016306:Vena Cava Filters / Q000009:adverse effects / Q000592:standards*
chemical_list: D007205:Indium Radioisotopes