title: Impact of antihelminthic treatment on infection by Ascaris lumbricoides, Trichuris trichiura and hookworms in Covas, a rural community of Pernambuco, Brazil.
abstract: This work aims to evaluate the impact of drug treatment on infection by Ascaris lumbricoides (Al), Trichuris trichiura (Tt) and hookworms (Hook) in a rural community from the sugar-cane zone of Pernambuco, Brazil. Four parasitological surveys were carried out from March 2001 to March 2002. Individual diagnosis was based on eight slides (four by the Kato-Katz method and four by the Hoffman method) per survey. Infected subjects were assigned to two groups for treatment with either albendazole (n = 62) or mebendazole (n = 57). Prevalence of infection fell significantly (p < 0.05) one month after treatment: Al (from 47.7% to 6.6%); Tt (from 45.7% to 31.8%) and Hook (from 47.7% to 24.5%). One year after treatment, infections by Tt and Hook remained significantly below pre-control levels. A substantial decrease in single-infection cases and multiple infections was found. Egg-negative rate was significant for Al (94.0%), Hook (68.3%) but not for Tt (45.5%), and did not differ significantly between subjects treated with mebendazole or albendazole. Egg counts fell significantly in the individuals remaining positive for Tt. It is recommended that antihelminthic treatment should be selective and given at yearly intervals preferably with albendazole, due to its cost-effectiveness.
authors.affiliation: Departamento de Biologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: Luciana Carvalho
authors.initials: LC
authors.lastname: Zani
authors.forename: Tereza Cristina
authors.initials: TC
authors.lastname: Favre
authors.forename: Otávio Sarmento
authors.initials: OS
authors.lastname: Pieri
authors.forename: Constança Simões
authors.initials: CS
authors.lastname: Barbosa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015766:Albendazole / Q000627:therapeutic use*; D000723:Ancylostomatoidea / Q000302:isolation & purification; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D017164:Ascaris lumbricoides / Q000302:isolation & purification; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005243:Feces / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006373:Helminthiasis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use*; D008875:Middle Aged; D010270:Parasite Egg Count; D015995:Prevalence; D012424:Rural Population; D014258:Trichuris / Q000302:isolation & purification
chemical_list: D000871:Anthelmintics; D008463:Mebendazole; D015766:Albendazole