title: Circadian variation of the efficacy of thrombolytic therapy in acute myocardial infarction-isn't the time ripe for cardiovascular chronotherapy?
abstract: This study was designed to assess the circadian variation of the efficacy of thrombolytic therapy (TT) in 163 patients with acute myocardial infarction. Statistical analysis of the results suggests the existence of circadian variation in the efficacy of thrombolytic therapy with marked early morning resistance and significantly better late daytime results. There is a strong relationship between the normal physiologic rhythms of biochemical, hemodynamic, and hematologic parameters, observed in patients with CAD and the circadian fluctuations of efficacy of TT. Obviously the efficacy of TT is influenced by more evident impact of chronorisk factors during the early morning hours.
authors.affiliation: Cardiology Department, Epidemiology Research Institute, Barzilai Medical Center Campus, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ashkelon, Israel. leonardo@barzi.health.gov.il
authors.forename: Leonardo H
authors.initials: LH
authors.lastname: Reisin
authors.forename: Nadya
authors.initials: N
authors.lastname: Pancheva
authors.forename: Michael
authors.initials: M
authors.lastname: Berman
authors.forename: Vladimir
authors.initials: V
authors.lastname: Khalameizer
authors.forename: Jamal
authors.initials: J
authors.lastname: Jafary
authors.forename: Chaim
authors.initials: C
authors.lastname: Yosefy
authors.forename: Yosef
authors.initials: Y
authors.lastname: Blaer
authors.forename: Ilia
authors.initials: I
authors.lastname: Manevich
authors.forename: Ronit
authors.initials: R
authors.lastname: Peled
authors.forename: Shimon
authors.initials: S
authors.lastname: Scharf
mesh_terms: D019454:Chronotherapy; D002940:Circadian Rhythm; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D015425:Myocardial Reperfusion; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015912:Thrombolytic Therapy; D016896:Treatment Outcome