title: Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways.
abstract: Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in parallel. The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA.
authors.affiliation: Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Moese
authors.forename: Matthias
authors.initials: M
authors.lastname: Selbach
authors.forename: Terry
authors.initials: T
authors.lastname: Kwok
authors.forename: Volker
authors.initials: V
authors.lastname: Brinkmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: König
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Meyer
authors.forename: Steffen
authors.initials: S
authors.lastname: Backert
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism; D004847:Epithelial Cells / Q000382:microbiology* / Q000648:ultrastructure; D005753:Gastric Mucosa / Q000166:cytology / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D015398:Signal Transduction; D014162:Transfection; D014774:Virulence
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori