title: [CHARM study--new strategy for the treatment of heart failure].
abstract: CHARM (candesartan in heart failure assessment of reduction in mortality and morbidity) is the largest trial program in chronic heart failure. To elucidate the effect of candesartan on various symptomatic chronic heart failure, the randomization protocol was used in 3 separate trial arms: 2028 with LVEF < 40% who could not tolerate ACE inhibitors; 2548 with LVEF < 40% who already were taking ACE inhibitor; and 3023 with LVEF > 40%. The overall mortality benefit of the candesartan was better than placebo. In the 2 trial arms that included patients with LVEF < 40%, incidence of the mortality and hospitalization was significantly lower with candesartan than with placebo. It may be the new evidence of angiotensin receptor blocker on 3 other types of heart failure.
authors.affiliation: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001713:Biphenyl Compounds; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012084:Renin-Angiotensin System / Q000502:physiology; D013777:Tetrazoles / Q000627:therapeutic use*; D016277:Ventricular Function, Left
chemical_list: D000319:Adrenergic beta-Antagonists; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D013777:Tetrazoles; C081643:candesartan