title: Diagnosis and treatment of acne.
abstract: Acne can cause significant embarrassment and anxiety in affected patients. It is important for family physicians to educate patients about available treatment options and their expected outcomes. Topical retinoids, benzoyl peroxide, sulfacetamide, and azelaic acid are effective in patients with mild or moderate comedones. Topical erythromycin or clindamycin can be added in patients with mild to moderate inflammatory acne or mixed acne. A six-month course of oral erythromycin, doxycycline, tetracycline, or minocycline can be used in patients with moderate to severe inflammatory acne. A low-androgen oral contraceptive pill is effective in women with moderate to severe acne. Isotretinoin is reserved for use in the treatment of the most severe or refractory cases of inflammatory acne. Because of its poor side effect profile and teratogenicity, isotretinoin (Accutane) must by prescribed by a physician who is a registered member of the manufacturer's System to Manage Accutane-Related Teratogenicity program.
authors.affiliation: Wake Forest University School of Medicine, Department of Dermatology, Winston-Salem, North Carolina 27157-1071, USA. sfeldman@wfubmc.edu
authors.forename: Steven
authors.initials: S
authors.lastname: Feldman
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Careccia
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Barham
authors.forename: John
authors.initials: J
authors.lastname: Hancox
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D012176:Retinoids / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D003276:Contraceptives, Oral; D012176:Retinoids