title: Live birth with sperm cryopreserved for 21 years prior to cancer treatment: case report.
abstract: Advances in cancer treatment have led to significant improvements in the likelihood of reaching remission and long-term survival for men. Chemo- and radiotherapy-induced infertility are significant treatment side effects. Cryopreservation before the start of treatment enables sperm to be stored, thereby preserving the man's potential fertility. Here, we describe the successful use (with ICSI) of sperm cryopreserved prior to cancer treatment, for a total of 21 years. We believe this to be the longest period of sperm cryopreservation, resulting in a live birth, so far reported in the literature.
authors.affiliation: Department of Reproductive Medicine, St Mary's Hospital, Manchester M13 0JH, UK. greg.horne@cmmc.nhs.uk
authors.forename: G
authors.initials: G
authors.lastname: Horne
authors.forename: A D
authors.initials: AD
authors.lastname: Atkinson
authors.forename: E H E
authors.initials: EH
authors.lastname: Pease
authors.forename: J P
authors.initials: JP
authors.lastname: Logue
authors.forename: D R
authors.initials: DR
authors.lastname: Brison
authors.forename: B A
authors.initials: BA
authors.lastname: Lieberman
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa; D013724:Teratoma / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D013997:Time Factors