The ever-increasing complexities of the exon junction complex.
Over the past decade many studies have revealed a complex web of interconnections between the numerous steps required for eukaryotic gene expression. One set of interconnections link nuclear pre-mRNA splicing and the subsequent metabolism of the spliced mRNAs. It is now apparent that the means of connection is a set of proteins, collectively called the exon junction complex, which are deposited as a consequence of splicing upstream of mRNA exon-exon junctions.
Tange
Thomas Ø
TØ
Howard Hughes Medical Institute, Department of Biochemistry, MS009, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA.
Nott
Ajit
A
Moore
Melissa J
MJ
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D005091:Exons; D006801:Humans; D014176:Protein Biosynthesis; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D017381:Spliceosomes / Q000235:genetics / Q000378:metabolism
D012322:RNA Precursors; D012333:RNA, Messenger