title: Immunopharmacology of CpG oligodeoxynucleotides and ribavirin.
abstract: To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.
authors.affiliation: Coley Pharmaceutical GmbH, Elisabeth-Selbert-Strasse 9, D-40764 Langenfeld, Germany. jvollmer@coleypharma.com
authors.forename: Jörg
authors.initials: J
authors.lastname: Vollmer
authors.forename: Robert
authors.initials: R
authors.lastname: Rankin
authors.forename: Hanna
authors.initials: H
authors.lastname: Hartmann
authors.forename: Marion
authors.initials: M
authors.lastname: Jurk
authors.forename: Ulrike
authors.initials: U
authors.lastname: Samulowitz
authors.forename: Tanja
authors.initials: T
authors.lastname: Wader
authors.forename: Andrea
authors.initials: A
authors.lastname: Janosch
authors.forename: Christian
authors.initials: C
authors.lastname: Schetter
authors.forename: Arthur M
authors.initials: AM
authors.lastname: Krieg
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D018925:Chemokines / Q000096:biosynthesis; D016207:Cytokines / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000819:agonists*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D016328:NF-kappa B / Q000187:drug effects; D009841:Oligonucleotides / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000819:agonists*; D012254:Ribavirin / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects / Q000378:metabolism; D051217:Toll-Like Receptor 9; D014162:Transfection
chemical_list: D000276:Adjuvants, Immunologic; D000998:Antiviral Agents; D018925:Chemokines; D016207:Cytokines; D004268:DNA-Binding Proteins; D016328:NF-kappa B; D009841:Oligonucleotides; D011956:Receptors, Cell Surface; C495371:TLR9 protein, human; D051217:Toll-Like Receptor 9; D012254:Ribavirin