Microscopic polyangiitis associated with diffuse panbronchiolitis.
There are several case reports of systemic vasculitis associated with chronic suppurative lung diseases. We describe a 46-year-old female, previously diagnosed as having diffuse panbronchiolitis (DPB), presenting with hemosputum and dyspnea. Her serum titer of MPO-ANCA was positive together with a high titer of BPI-ANCA. Chest X-ray and chest CT scan showed pulmonary hemorrhage, and the renal biopsy specimen revealed necrotizing, crescentic glomerulonephritis. She was diagnosed as having ANCA-associated vasculitis, and more specifically, microscopic polyangiitis accompanied by DPB. She was treated with methylprednisolone pulse therapy, followed by intravenous cyclophosphamide. This case suggested a possible association with chronic bacterial infection, which may play a role in the pathogenesis of ANCA-associated vasculitis.
Park
Jangchul
J
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi.
Banno
Shogo
S
Sugiura
Yoshiki
Y
Yoshikawa
Kosho
K
Naniwa
Taio
T
Wakita
Kaori
K
Hayami
Yoshihito
Y
Sato
Shigeki
S
Ueda
Ryuzo
R
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis; D001988:Bronchiolitis / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D002772:Cholera Toxin; D005260:Female; D006801:Humans; D008875:Middle Aged; D009195:Peroxidase; D011859:Radiography; D014657:Vasculitis / Q000150:complications*
D019268:Antibodies, Antineutrophil Cytoplasmic; D002772:Cholera Toxin; D009195:Peroxidase