title: [Four cases of hypopharyngeal cancer treated with docetaxel, cisplatin, and 5-FU followed by radiotherapy and/or neck dissection].
abstract: We treated 4 patients with hypopharyngeal cancer, each of whom had a complete response after 2 cycles of chemotherapy with docetaxel, cisplatin, and 5-FU followed by radiation and/or neck dissection. Twenty-one months to 2 years after this therapy, 3 patients had no recurrence and no metastasis with their laryngeal framework and function preserved. Chemotherapy including docetaxel, cisplatin, and 5-FU is a useful treatment for early head and neck cancer.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, Osaka General Medical Center.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyahara
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nario
authors.forename: Naoki
authors.initials: N
authors.lastname: Matsushiro
authors.forename: Hisanori
authors.initials: H
authors.lastname: Sasai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajikawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy* / Q000601:surgery; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D020360:Neoadjuvant Therapy; D011379:Prognosis; D011879:Radiotherapy Dosage; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil