Fluorometric variable-temperature kinetics investigations of the transesterification reaction of procaine with aliphatic alcohols.
OBJECTIVE
Variable-Temperature Kinetics has been used to obtain the rate constants of the reaction at various temperatures during one kinetic run.


METHODS
Pseudo-first-order rate constants for the transesterification of procaine with aliphatic alcohols ethanol, n-propanol and tert-butanol were obtained by the fluorescence spectroscopy using the variable-temperature kinetics (VTK) method.


RESULTS
The activation parameters of the reactions were calculated (24-28 kcal x mol(-1)). The half-life of the procaine decreases in the ethanol solution compared with the other alcoholic solutions in the presence of sodium ethoxide.


CONCLUSIONS
The investigation time of the reactions is reduced to one-tenth of the one used for usual kinetic methods.
Harifi-Mood
Ali Reza
AR
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Haghighi
Saeed
S
Gholami
Mohammad Reza
MR
D000433:1-Propanol / Q000737:chemistry; D000438:Alcohols / Q000737:chemistry; D004355:Drug Stability; D004951:Esterification; D000431:Ethanol / Q000031:analogs & derivatives* / Q000737:chemistry*; D006207:Half-Life; D007700:Kinetics; D011343:Procaine / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods; D013696:Temperature
D000438:Alcohols; C098088:sodium ethoxide; D000431:Ethanol; D011343:Procaine; D000433:1-Propanol