title: Validation of the CBF, CBV, and MTT values by perfusion MRI in chronic occlusive cerebrovascular disease: a comparison with 15O-PET.
abstract: OBJECTIVE
  To evaluate the reliability of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) values obtained by deconvolution algorithm perfusion-weighted MR imaging (D-PWI), we compared these values with those obtained by first-moment algorithm perfusion-weighted MR imaging (F-PWI) and 15O-PET.
  
  
  METHODS
  Six healthy volunteers and eleven patients with chronic occlusive cerebrovascular disease were studied with both perfusion-weighted MR imaging and 15O-PET, and region-of-interest analyses were performed. Normalization factors for CBF and CBV values obtained by D-PWI were determined as the mean values of 15O-PET divided by those of D-PWI in healthy volunteers. Then these values were used in analyzing the data of the patients.
  
  
  RESULTS
  The MTT value obtained by D-PWI was 6.1 +/- 0.5 seconds on the non-occluded side, 6.4 +/- 0.7 seconds on the minimally to moderately stenosed side, and 6.7 +/- 1.2 seconds on the severely stenosed to occluded side. These values were significantly correlated with those obtained by F-PWI (r = 0.83; P < .001), and with those obtained by 15O-PET (r = 0.78; P < .05). However, the CBF and CBV values obtained by D-PWI did not correlate with those obtained by 15O-PET.
  
  
  CONCLUSIONS
  MTT values obtained by D-PWI were reliable parameters of cerebral hemodynamics, but the CBF and CBV values obtained by D-PWI were not always reliable.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582 Japan. kkaneko-kyu@umin.ac.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kaneko
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: Futoshi
authors.initials: F
authors.lastname: Mihara
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Atsuo
authors.initials: A
authors.lastname: Tanaka
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Koga
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000328:Adult; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed
chemical_list: D010104:Oxygen Radioisotopes