title: Role of the tissue factor pathway in the pathogenesis and management of multiple organ failure.
abstract: Sepsis is caused by a dysregulated immune response to infection and, without intervention, can lead to septic shock and multiple organ failure. A leading cause of morbidity and mortality in intensive care units worldwide, severe sepsis is also associated with a considerable cost burden that places significant strain on global healthcare budgets. The development of an efficacious and cost-effective treatment strategy is therefore of vital importance to today's intensive care physicians. This paper will examine the pathophysiology of sepsis and multiple organ dysfunction before reviewing trials recently undertaken to investigate three potential anticoagulant therapies: antithrombin III, activated protein C, and tissue factor pathway inhibitor. Finally, other recent developments in the care of sepsis patients will be briefly examined.
authors.affiliation: Critical Care Services, Cardiff & Vale NHS Trust, Wales, UK. mark.smithies@cardiffandvale.wales.nhs.uk
authors.forename: Mark N
authors.initials: MN
authors.lastname: Smithies
authors.forename: Christine B
authors.initials: CB
authors.lastname: Weaver
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D019468:Disease Management; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology* / Q000628:therapy; D018805:Sepsis / Q000150:complications* / Q000628:therapy; D013925:Thromboplastin / Q000378:metabolism / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D013925:Thromboplastin