title: Rapid-sequence phosphorus-31 magnetic resonance spectroscopy of the human heart using a 1.5-T clinical system.
abstract: OBJECTIVE
  To compare a 'standard' slow phosphorus-31 magnetic resonance spectroscopy (31P-MRS) sequence with two faster sequences in phantoms and healthy volunteers using a 1.5-T clinical system.
  
  
  METHODS
  Complete 3D localization was performed using a 2D phosphorus chemical-shift imaging sequence in combination with 30-mm axial slice-selective excitation. Two 31P-MRS rapid sequences (RS8-4: 8 x 8 phase-encoding, with an average of 4 acquisitions, and RS16-1: 16 x 16 phase-encoding, 1 acquisition) were compared with the standard sequence (StdP: 16 x 16 phase-encoding, with an average of 8 acquisitions) in phantom and healthy volunteers.
  
  
  RESULTS
  Acquisition time for the 31P-MRS procedure with StdP, RS8-4, and RS16-1 in the healthy volunteer studies ranged from 30 to 45, 3 to 5, and 3 to 5 minutes, respectively. Metabolite measurements of healthy volunteers obtained from 31P-MRS using RS8-4 correlated with values obtained using StdP (PCr r2=0.63, P<0.001; ATP r=0.41, P<0.01 and PCr/ATP ratio r2=0.25, P<0.05). There was no correlation between StdP and RS16-1 for either ATP or the PCr/ATP ratio (r2=0.03, P=0.60, and r2=0.11, p=0.26, respectively). Reproducibility (intensity of phosphorus signal) with RS16-1 was worse than that of RS8-4 or StdP.
  
  
  CONCLUSIONS
  31P-MRS using RS8-4 may be a valid diagnostic tool for patients with cardiac diseases.
authors.affiliation: Department of Radiological Technology, College of Medical Sciences, Tohoku University, Sendai, Japan. chida@rad.cms.tohoku.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Chida
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Nagasaka
authors.forename: H
authors.initials: H
authors.lastname: Otani
authors.forename: M
authors.initials: M
authors.lastname: Kohzuki
authors.forename: M
authors.initials: M
authors.lastname: Zuguchi
mesh_terms: D000328:Adult; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D019047:Phantoms, Imaging; D010758:Phosphorus; D011877:Radionuclide Imaging; D013997:Time Factors
chemical_list: D010758:Phosphorus