title: Adiponectin but not resistin is associated with insulin resistance-related phenotypes in baboons.
abstract: OBJECTIVE
  The hormones adiponectin and resistin have been associated with insulin resistance. This paper analyzed the potential relationship between adiponectin and resistin and insulin resistance-related phenotypes in baboons.
  
  
  METHODS
  One hundred eight adult baboons (84 female and 24 male) were studied. Weight was measured, and a blood sample was collected under fasting conditions for plasma and monocyte isolation. Fasting glucose, insulin, C-peptide, and adiponectin levels in plasma were measured by standard methods. Insulin resistance was calculated by the homeostasis model assessment index. Resistin mRNA abundance in monocytes was determined by real-time quantitative reverse transcription-polymerase chain reaction. Data were clustered by weight tertiles for statistical analysis.
  
  
  RESULTS
  As observed in humans, the insulin resistance-related phenotypes were related to weight, plasma levels of adiponectin, and C-peptide. No significant relationship between resistin circulating levels or expression in monocytes and insulin resistance-related phenotypes was found in baboons.
  
  
  CONCLUSIONS
  These findings suggest that resistin is not associated with insulin resistance. However, previous observations of relationships among weight, adiponectin, and insulin resistance are confirmed.
authors.affiliation: Division of Nutritional Sciences, University of Texas, Austin, USA.
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Tejero
authors.forename: Jeanne H
authors.initials: JH
authors.lastname: Freeland-Graves
authors.forename: J Michael
authors.initials: JM
authors.lastname: Proffitt
authors.forename: Kyle W
authors.initials: KW
authors.lastname: Peebles
authors.forename: Guowen
authors.initials: G
authors.lastname: Cai
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Cole
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
mesh_terms: D052242:Adiponectin; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood; D005215:Fasting; D005260:Female; D015870:Gene Expression; D006706:Homeostasis; D006729:Hormones, Ectopic / Q000097:blood* / Q000235:genetics; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009000:Monocytes / Q000737:chemistry; D010215:Papio / Q000097:blood*; D010641:Phenotype; D011506:Proteins / Q000032:analysis*; D012333:RNA, Messenger / Q000097:blood; D052243:Resistin; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D002096:C-Peptide; D006729:Hormones, Ectopic; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D012333:RNA, Messenger; D052243:Resistin