title: Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12.
abstract: We examined the safety and immunogenicity of a human leukocyte antigen-based HIV envelope polyvalent synthetic peptide vaccine, C4-V3, alone and in combination with subcutaneous IL-12 in nine HIV-infected patients. Lymphocyte proliferative responses increased threefold or more to all four peptides at two consecutive post-immunization timepoints for four individuals. Three responders had received IL-12, suggesting a possible adjuvant effect of Il-12. Transient mild injection site reactions (7.9) and systemic symptoms (3/9) occurred.
authors.affiliation: Department of Medicine, Section of Infectious Diseases, Rush Medical College, Chicago, IL, USA.
authors.forename: Beverly E
authors.initials: BE
authors.lastname: Sha
authors.forename: Michelle
authors.initials: M
authors.lastname: Onorato
authors.forename: John A
authors.initials: JA
authors.lastname: Bartlett
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Bosch
authors.forename: Evgenia
authors.initials: E
authors.lastname: Aga
authors.forename: Mostafa
authors.initials: M
authors.lastname: Nokta
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Adams
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.forename: John
authors.initials: J
authors.lastname: Eldridge
authors.forename: Richard B
authors.initials: RB
authors.lastname: Pollard
mesh_terms: D016915:AIDS Vaccines / Q000009:adverse effects / Q000276:immunology*; D000276:Adjuvants, Immunologic; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007271:Injections, Intradermal; D018664:Interleukin-12 / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D000276:Adjuvants, Immunologic; D006680:HLA Antigens; D014614:Vaccines, Synthetic; D018664:Interleukin-12