Biological properties of staphylococcal enterotoxin-like toxin type R.
We investigated the biological properties of a novel staphylococcal enterotoxin-like putative toxin, staphylococcal enterotoxin-like toxin type R (SElR). Major histocompatibility complex class II molecules were required for T-cell stimulation by SElR. SElR stimulated T cells bearing receptors Vbeta 3, 11, 12, 13.2, and 14. These results suggested that SElR acts as a superantigen.
Omoe
Katsuhiko
K
Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University, Ueda 3-18-8, Morioka, Iwate 020-8550, Japan. omo@iwate-u.ac.jp
Imanishi
Ken'ichi
K
Hu
Dong-Liang
DL
Kato
Hidehito
H
Takahashi-Omoe
Hiromi
H
Nakane
Akio
A
Uchiyama
Takehiko
T
Shinagawa
Kunihiro
K
D000818:Animals; D004768:Enterotoxins / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D011817:Rabbits; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013211:Staphylococcus aureus / Q000276:immunology* / Q000378:metabolism; D018089:Superantigens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D004768:Enterotoxins; D000949:Histocompatibility Antigens Class II; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018089:Superantigens