Selective dopamine filter of glutamate striatal afferents.
Corticostriatal glutamate afferents and mesostriatal dopamine afferents commonly converge onto the same postsynaptic spines of medium projection neurons. The consequent synaptic triad provides an ideal configuration for dopamine modulation of glutamatergic transmission. In this issue of Neuron, Bamford et al. report that dopamine inhibits glutamate release in a selective manner by activating presynaptic D2 receptors.
Dani
John A
JA
Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030 USA.
Zhou
Fu-Ming
FM
D000344:Afferent Pathways / Q000378:metabolism* / Q000648:ultrastructure; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000648:ultrastructure; D004298:Dopamine / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology
D017448:Receptors, Dopamine D2; D018698:Glutamic Acid; D004298:Dopamine