A modular and concise total synthesis of (+/-)-daurichromenic acid and analogues.
A modular and concise total synthesis of (+/-)-daurichromenic acid has been accomplished in four steps from ethyl acetoacetate, ethyl crotonate, and trans,trans-farnesal. A series of analogues of this natural product, which has potent anti-HIV activity, were also prepared from ethyl or methyl acetoacetate and a series of readily available alpha,beta-unsaturated esters and aldehydes.
Hu
Hongjuan
H
Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6.
Harrison
Tyler J
TJ
Wilson
Peter D
PD
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002839:Chromans / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D002839:Chromans; C489925:daurichromenic acid