title: The archaeal signal recognition particle: steps toward membrane binding.
abstract: Signal recognition particles and their receptors target ribosome nascent chain complexes of preproteins toward the protein translocation apparatus of the cell. The discovery of essential SRP components in the third urkingdom of the phylogenetic tree, the archaea (Woese, C. R., and Fox, G. E. (1977). Proc. Natl. Acad. Sci. U.S.A. 74, 5088-5090) raises questions concerning the structure and composition of the archaeal signal recognition particle as well as the functions that route nascent prepoly peptide chains to the membrane. Investigations of the archaeal SRP pathway could therefore identify novel aspects of this process not previously reported or unique to archaea when compared with the respective eukaryal and bacterial systems.
authors.affiliation: Department of Biochemistry, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. moll@biochem.uni-luebeck.de
authors.forename: Ralf G
authors.initials: RG
authors.lastname: Moll
mesh_terms: D001105:Archaea / Q000502:physiology*; D019843:Archaeal Proteins / Q000378:metabolism*; D001693:Biological Transport, Active / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology*; D019642:RNA, Archaeal / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D018271:Signal Recognition Particle / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019843:Archaeal Proteins; D008565:Membrane Proteins; D019642:RNA, Archaeal; D018160:Receptors, Cytoplasmic and Nuclear; D018000:Receptors, Peptide; D018271:Signal Recognition Particle; C036318:signal peptide receptor