title: Combinatorial chemistry: libraries from libraries, the art of the diversity-oriented transformation of resin-bound peptides and chiral polyamides to low molecular weight acyclic and heterocyclic compounds.
abstract: Combinatorial chemistry has deeply impacted the drug discovery process by accelerating the synthesis and screening of large numbers of compounds having therapeutic and/or diagnostic potential. These techniques offer unique enhancement in the potential identification of new and/or therapeutic candidates. Our efforts over the past 10 years in the design and diversity-oriented synthesis of low molecular weight acyclic and heterocyclic combinatorial libraries derived from amino acids, peptides, and/or peptidomimetics are described. Employing a "toolbox" of various chemical transformations, including alkylation, oxidation, reduction, acylation, and the use of a variety of multifunctional reagents, the "libraries from libraries" concept has enabled the continued development of an ever-expanding, structurally varied series of organic chemical libraries.
authors.affiliation: Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
authors.forename: Adel
authors.initials: A
authors.lastname: Nefzi
authors.forename: John M
authors.initials: JM
authors.lastname: Ostresh
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yu
authors.forename: Jongping
authors.initials: J
authors.lastname: Yu
authors.forename: Richard A
authors.initials: RA
authors.lastname: Houghten
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006839:Hydrocarbons, Acyclic / Q000737:chemistry*; D015394:Molecular Structure; D008970:Molecular Weight; D009757:Nylons / Q000737:chemistry*; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry*; D012117:Resins, Synthetic
chemical_list: D000596:Amino Acids; D006571:Heterocyclic Compounds; D006839:Hydrocarbons, Acyclic; D009757:Nylons; D019151:Peptide Library; D010455:Peptides; D012117:Resins, Synthetic