[Experimental study on inhibitory effect of langchuangjing granule on lupoid change of kidney in lupus-prone mice].
OBJECTIVE
To study the effect and mechanism of Langchuangjing Granule (LCJ) in inhibiting the lupoid change of kidney in lupus-prone mice.


METHODS
Intervention therapy was applied to three group of BW female mice of lupus, 3 months in age, for 6-12 weeks with LCJ, prednisone and LCJ + prednisone respectively to observe the dynamic development of disease, changes of CD4+, CD8+ and CD54 expression, and the effect on pathology of renal corpuscles.


RESULTS
Both western and Chinese medicines can partially improve the symptoms and plasma CD4+ and CD8+ distribution, inhibit the increase of serum ICAM-1 content and the high expression of CD54 in surface of lymphocyte of peripheral blood, suppress the atrophy of renal corpuscles and the proliferation of mesangial cell. The optimal effect was showed by the combination of LCJ and prednisone.


CONCLUSIONS
LCJ could effectively control and improve the genesis and development of lupoid changes in model mice, and regulate the cellular immune function, inhibit the excessive immune reaction, and improve the pathology of lupoid nephritis, it could cooperate with western medicine to give full play of its effective role and show the superiority in treatment.
Zhu
Fang-shi
FS
Shaoyifu Institute of Clinical Medicine, Zhejiang University, Hangzhou 310016. zhufs@zju.edu.cn
Jin
Shi
S
Wang
Yue
Y
D000818:Animals; D016516:CD4-CD8 Ratio; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008181:Lupus Nephritis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D008517:Phytotherapy; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D018799:Intercellular Adhesion Molecule-1