title: Trypanocidal activity of chemical constituents from Lychnophora salicifolia Mart.
abstract: The ethyl acetate extract from leaves plus inflorescences of L. salicifolia showed significant trypanocidal activity against trypomastigote forms of T. cruzi, which was due to the flavonoid quercetin-7,3',4'-trimethyl ether and the sesquiterpenoid lychnopholic acid. Despite the use of some species of Lychnophora in folk medicine for pain relief, crude extracts from L. salicifolia Mart. showed no antinociceptive activity in the mouse writhing test.
authors.affiliation: Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Ribeirao Preto, SP, Brazil.
authors.forename: Christiane Oliveira
authors.initials: CO
authors.lastname: Jordão
authors.forename: Walter
authors.initials: W
authors.lastname: Vichnewski
authors.forename: Glória Emília Petto
authors.initials: GE
authors.lastname: de Souza
authors.forename: Sérgio
authors.initials: S
authors.lastname: Albuquerque
authors.forename: João Luis Callegari
authors.initials: JL
authors.lastname: Lopes
mesh_terms: D000818:Animals; D019659:Asteraceae; D014355:Chagas Disease / Q000517:prevention & control; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; D014344:Trypanocidal Agents