title: [Severe bone marrow necrosis associated with septic shock in the intensive care unit].
abstract: Unexplained cytopenias can be related to bone marrow necrosis (BMN) in critically ill patients as it can be encountered in several diseases or life-threatening conditions. We present the case of a 39-year-old woman with pancytopenia revealing a BMN in the setting of an acute pyelonephritis with septic shock, multiple organ failure and sickle cell trait. After a short review on the subject, we suggest that various haematological abnormalities occurring in critically ill patients may be related to a mild to severe marrow necrosis.
authors.affiliation: Service d'anesthésie-réanimation, hôpital européen Georges-Pompidou, 20, rue Leblanc, 75908 Paris cedex 15, France. pcadi@invivo.edu
authors.forename: P
authors.initials: P
authors.lastname: Cadi
authors.forename: Y E
authors.initials: YE
authors.lastname: Claessens
authors.forename: A
authors.initials: A
authors.lastname: Cariou
authors.forename: D
authors.initials: D
authors.lastname: Safran
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000150:complications; D001855:Bone Marrow Diseases / Q000150:complications*; D003422:Critical Care; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D009102:Multiple Organ Failure / Q000473:pathology; D009336:Necrosis; D010198:Pancytopenia / Q000150:complications; D011552:Pseudomonas Infections / Q000150:complications; D011704:Pyelonephritis / Q000150:complications; D012772:Shock, Septic / Q000150:complications* / Q000382:microbiology; D012805:Sickle Cell Trait