[Postcatelectrotonic potentials and trace changes in the nerve fiber excitability].
When cathode subthreshold impulse was turned off, excitable membranes of isolated nerve fibres and nervous trunk show postelectrotonic depolarisation (PED), that is a slow recovery of membrane potential to the resting level. PED of the single nodes of Ranvier and nervous trunk is registered not only in normal conditions, but also after complete block of sodium channels. The size and duration of nervous trunk PED under subthreshold depolarising current increase along with duration of applied depolarisation: when cathode current 1 ms in duration was used, they were 0.093 +/- +/- 0.004 mV and 7.123 +/- 0.576 ms, respectively; when current was 5 ms in duration, they were 0.189 +/- 0.005 mV and 23.212 +/- 1.186 ms, whereas a 10-ms depolarisation yields values of 0.220 +/- 0.011 mV and 68.721 +/- 3.389 ms. Application of the train of catelectrotonic impulses leads to PED built-up. As PED is found not only in normal conditions but also after complete block of sodium channels, it is reasonable to suggest that the most probable reason for PED is an outward potassium current.
Katalymov
L L
LL
Ulyanovsk I. N. Ulyanov State Pedagogical University, 432980, Ulyanovsk, 4 Pl. 100-letiya so dnia Rozhdeniya V. I. Lenina, Russia.
Evstigneev
D A
DA
D000200:Action Potentials; D000818:Animals; D066298:In Vitro Techniques; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D011895:Rana ridibunda; D011901:Ranvier's Nodes / Q000187:drug effects / Q000502:physiology; D026941:Sodium Channel Blockers / Q000494:pharmacology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
D015221:Potassium Channels; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D013779:Tetrodotoxin