[Teratogenic effect of rubber components].
This study was performed to evaluate the effects of prenatal development of rats were exposed to Polnoks R and its monomer 2,2,4-trimethyl-1,2-dihydroquinoline (TMDHQ) by gavage every day on days 6-15 of gestation at doses equivalent 6%, 13% and 25% of LD50. Polnoks R and TMDHQ administered per os associated with significant maternal toxicity, embryonal lethality, retarded fetal development and congenital defects. Polnoks R induced skeletal malformations, internal hydrocephalus, and hydronephrosis. 2,2,4-trimethyl-1,2-dihydroquinoline produced internal malformations (exencephale, hydrocephalus, anophthalmia, hydronephrosis and renal hypoplasia) and skeletal malformations of ribs and vertebrae. Polnoks R monomer--2,2,4-trimethyl-1,2-dihydroquinoline is used as an antioxidant in elastomer and rubber productions. Polnoks R and its monomer 2,2,4-trimethyl-1,2-dihydroquinoline are teratogenic to rats and induces CNS, kidneys and skeletal defects.
Sitarek
Krystyna
K
Zakładu Toksykologii i Kancerogenezy Instytut Medycyny Pracy im. prof. J. Nofera w Łodzi. ksitarek@imp.lodz.pl
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000284:Administration, Oral; D000818:Animals; D021461:Animals, Outbred Strains; D000975:Antioxidants / Q000008:administration & dosage / Q000633:toxicity; D001835:Body Weight / Q000187:drug effects; D047108:Embryonic Development / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D011297:Prenatal Exposure Delayed Effects; D011804:Quinolines / Q000633:toxicity*; D051381:Rats; D012408:Rubber / Q000633:toxicity
D000975:Antioxidants; D011804:Quinolines; C053059:1,2-dihydro-2,2,4-trimethylquinoline; D012408:Rubber