Centrosomes and microtubules: wedded with a ring.
How centrosomes nucleate microtubule growth is a question that has puzzled cell biologists for decades. It has been suspected for some time that a centrosome contains multiple copies of a basic microtubule-nucleating structure, each of which is responsible for nucleating a single microtubule. This suspicion has now been confirmed. A ring of gamma-tubulin molecules, associated with a large protein complex, apparently serves as the long-sought-after microtubule-nucleating structure.
Raff
J W
JW
Wellcome/CRC Institute, Dept of Genetics, Cambridge, UK.