Disseminated cutaneous B-cell lymphoma mimicking pseudolymphoma over a period of six years.
We describe a patient with a disseminated nodular cutaneous B-cell lymphoma, whose diagnosis was finally made after a long series of biopsies in different institutions in Europe and the United States. The differential diagnosis between lymphoma and pseudolymphoma was the recurrent problem throughout the patient's history because histologic and immunophenotypic criteria alone were not sufficient for differentiation. Molecular biology inconsistently detected clonal immunoglobulin rearrangements, which proves that careful clinicopathologic correlation remains mandatory. In contrast to a claimed "high-grade" malignant histology, this lymphoma responded with remission to PUVA therapy combined with intralesional corticosteroids, which is uncommon in the management of cutaneous B-lymphomas.
Gutermuth
Jan
J
Division of Environmental Dermatology and Allergy GSF/TUM, GSF-National Research Center For Environment and Health, and Department of Dermatology and Allergy Biederstein, Technical University of Munich, Germany. jan.gutermuth@gsf.de
Audring
Heike
H
Roseeuw
Diane
D
D001706:Biopsy; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D015322:Gene Rearrangement, B-Lymphocyte; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D011701:PUVA Therapy; D019310:Pseudolymphoma / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
D004273:DNA, Neoplasm