title: Is high PEEP low volume ventilation in burn patients beneficial? A retrospective study of 61 patients.
abstract: In burn care lung damage by inhalation injury is a major cause of mortality in burn patients. In the field of intensive care medicine ventilation strategies to reduce lung injury caused by ventilation are under investigation. The promising results of the application of pressure controlled high PEEP low volume (HPLV) ventilation prompted us to use this ventilation strategy in our burn ICU. To establish whether this ventilation regime is beneficial the charts of 61 consecutive patients needing artificial respiration were reviewed. A scoring system for PEEP level and tidal volume was developed and treatment groups with high PEEP and low volume and low PEEP high volume regimes were compared. No statistically significant differences could be found when comparing treatment versus mortality, the number of pulmonary complications or incidence of pneumothoraces. However, the trend showed a benefit in mortality for patients with an ABSI scoring up to 9, but at the same time pulmonary complications increase. The Horovitz oxygenation index showed no advantage for the HPLV Group. In a separate analysis we found a significant correlation between absolute PEEP and mortality. The correlation between PEEP level and mortality is a dynamic factor predicting outcome, This not been described yet and can be an addition to the static ABSI score. Differences between ventilation strategies were not as evident as expected in this retrospective study, so prospective randomized studies are needed.
authors.affiliation: Department of Plastic Surgery, Hand and Burn Surgery, University Hospital of the RWTH, Pauwelsstrasse 30, D-52074 Aachen, Germany. twolter@ukaachen.de
authors.forename: T P
authors.initials: TP
authors.lastname: Wolter
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
authors.forename: N
authors.initials: N
authors.lastname: Horvat
authors.forename: N
authors.initials: N
authors.lastname: Pallua
mesh_terms: D000328:Adult; D002059:Burns, Inhalation / Q000628:therapy*; D003422:Critical Care / Q000379:methods; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D015601:Injury Severity Score; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011175:Positive-Pressure Respiration / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D010100:Oxygen