X chromosome inactivation-mediated cellular mosaicism for the study of the monoclonal origin and recurrence of mouse tumors: a review.
X chromosome inactivation-mediated cellular mosaicism was applied to study the clonal nature of experimental and human tumors and to judge whether apparently recurrent tumors which appear after therapeutic treatment are truly due to recurrence or due to new induction of a second tumor. Results show that the majority of experimental and human tumors, including benign tumors, are monoclonal and that the majority of apparently recurrent tumors are due to true recurrence. A series of experimental studies on this topic are reviewed.
Tanooka
H
H
National Institute of Radiological Sciences, Anagawa, Inage-ku, Chiba 263-8555, Japan. tnk@nirs.go.jp
D000818:Animals; D019070:Cell Lineage; D002999:Clone Cells / Q000648:ultrastructure; D018450:Disease Progression; D004303:Dosage Compensation, Genetic; D006801:Humans; D008748:Methylcholanthrene; D051379:Mice; D008813:Mice, Inbred ICR; D009030:Mosaicism; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology / Q000532:radiotherapy; D014411:Neoplastic Stem Cells / Q000648:ultrastructure; D011882:Radiotherapy, High-Energy; D014178:Translocation, Genetic
D008748:Methylcholanthrene