Photoallergic contact dermatitis.
OBJECTIVE
To determine whether photoallergic contact dermatitis is as uncommon as it is usually considered to be and to review the associated clinical features.


METHODS
We reviewed the literature on photoallergic reactions induced by the topical contact of the skin with a chemical in the presence of, or followed by, exposure to UV or visible light. Some of the more recently observed photo-allergens and those presenting special clinical features are discussed.


RESULTS
The literature cites several topical substances that give rise to photoallergic contact dermatitis, some of them only exceptionally but others quite frequently. The clinical features are not always those of a eczematous eruption, and several parts of the body may be affected.


CONCLUSIONS
Many topical photoallergic culprits have been reported in the literature, the most important of which are sunscreen agents and, recently, non-steroidal anti-inflammatory agents (NSAIDs). Not at all exceptional is the occurrence of photoaggravation and recurrent transient or even persistent light reactions on previously exposed as well as non-exposed areas (often sparing the original application site), particularly with the NSAID ketoprofen. Moreover, cross-reactions with chemically-related as well as non-chemically related molecules are common. The potentially misleading clinical features observed in some cases, the diversity of the casual substances identified, and the low frequency with which photopatch testing is carried out in general indicate that the occurrence of photoallergic contact dermatitis might well be underestimated.
Goossens
An
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Contact Allergy Unit, Department of Dermatology, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium.
D000485:Allergens / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003429:Cross Reactions; D017454:Dermatitis, Photoallergic / Q000209:etiology*; D006801:Humans; D007660:Ketoprofen; D008027:Light / Q000009:adverse effects*; D013473:Sunscreening Agents / Q000009:adverse effects
D000485:Allergens; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013473:Sunscreening Agents; D007660:Ketoprofen