Amniotic fluid embolism with haemostasis complications: primary fibrinogenolysis or disseminated intravascular coagulation?
Amniotic fluid embolism (AFE) is characterized by the passage of amniotic fluid (AF) into the maternal circulation during or just after childbirth. AFE is a rare disorder occurring in 1/8,000 to 1/80,000 deliveries but with a maternal morbidity ranging from 26% in a recent report to 86% in earlier ones. In patients who survive, AFE may affect coagulation resulting in severe bleeding. While disseminated intravascular coagulation (DIC) is usually seen in such cases, we reported a case of AFE in which the hemostatic abnormalities were compatible with primary fibrinogenolysis rather than with DIC.
Biron-Andréani
C
C
Laboratoire d'Hématologie, Centre Hospitalier Universitaire, Montpellier, France. c-biron@chu-montpellier.fr
Morau
E
E
Schved
J-F
JF
Hédon
B
B
Dechaud
H
H
D000328:Adult; D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000209:etiology; D016913:Blood Component Transfusion; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000209:etiology; D004619:Embolism, Amniotic Fluid / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005342:Fibrinolysis; D006470:Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006487:Hemostasis; D006801:Humans; D011247:Pregnancy; D016896:Treatment Outcome