Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction.
BACKGROUND
Cyclooxygenase-2 (COX-2) has been reported to play an important role in the pathogenesis of a variety of cancers. Little is known about the relationship between bile duct cancer associated with pancreaticobiliary maljunction (PBM) and COX-2.


METHODS
We compared the expression of COX-2 in bile duct epithelium in bile duct cancer with or without PBM.


RESULTS
Immunohistochemical analysis showed that the rate of positive COX-2 expression was 42.9% for cancerous lesions and 7.1% for noncancerous lesions in cases of bile duct cancer without PBM. On the other hand, no positive expression of COX-2 was observed in cancerous lesion of bile duct cancer with PBM. Twenty % of the noncancerous bile duct mucosa with PBM was positive for COX-2.


CONCLUSIONS
COX-2 is expressed in bile duct cancer while it is not expressed in bile duct cancer accompanied by PBM.
Watanabe
Osamu
O
Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan.
Yoshimatsu
Kazuhiko
K
Shiozawa
Shunichi
S
Tsuchiya
Akira
A
Oshibe
Nobuyuki
N
Aiba
Motohiko
M
Ogawa
Kenji
K
D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D015529:Choledochal Cyst / Q000150:complications / Q000201:enzymology*; D051546:Cyclooxygenase 2; D004848:Epithelium / Q000201:enzymology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D008565:Membrane Proteins; D009367:Neoplasm Staging; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis*
D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases