Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro.
Scutellaria baicalensis (SbE) is a commonly used Chinese herb medicine and grape seed proanthocyanidins is a popular herbal supplement in the United States. Both herbs have been shown to possess potent antioxidant effects. Using an in vitro model to produce the reactive oxygen species (ROS) generation (H2O2/FeSO4 for hydroxyl radicals, xanthine/xanthine oxidase for suproxide), we observed that Scutellaria baicalensis and grape seed proanthocyanidins acted synergistically to scavenge ROS. Our data suggest that a combination of these two herbs can potentially enhance their antioxidant efficacy, allowing lower dosages of each drug to be used. This has the advantage of avoiding possible side effects that may arise when higher doses of a single herb are used in an attempt to achieve a maximum degree of antioxidant activity.
Shao
Zuo-Hui
ZH
Tang Center for Herbal Medicine Research, Emergency Medicine and Emergency Resuscitation Center, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
Vanden Hoek
Terry L
TL
Li
Chang-Qing
CQ
Schumacker
Paul T
PT
Becker
Lance B
LB
Chan
Kim Chai
KC
Qin
Yimin
Y
Yin
Jun-Jie
JJ
Yuan
Chun-Su
CS
D004357:Drug Synergism; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D044945:Proanthocyanidins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000737:chemistry*; D031364:Scutellaria baicalensis; D012639:Seeds; D027843:Vitis
C045076:Fenton's reagent; D016166:Free Radical Scavengers; D010936:Plant Extracts; D044945:Proanthocyanidins; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D007501:Iron