title: Stay close to your sister.
abstract: Yeast Sir2 protein regulates chromatin structure and suppresses recombination at the multiple tandem rDNA array. In the current issue of Cell, Kobayashi and colleagues reinvestigate rDNA dynamics in sir2 strains and find that Sir2 is necessary to recruit cohesins to the array, which influences the nature of rDNA recombination events.
authors.affiliation: Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA.
authors.forename: Robert J D
authors.initials: RJ
authors.lastname: Reid
authors.forename: Rodney
authors.initials: R
authors.lastname: Rothstein
mesh_terms: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D020090:Chromosome Segregation / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics*; D005656:Fungal Proteins; D006655:Histone Deacetylases / Q000235:genetics*; D008938:Mitosis / Q000235:genetics; D009154:Mutation / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics*; D011995:Recombination, Genetic / Q000235:genetics*; D017385:Sequence Homology; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000235:genetics*; D056565:Sirtuin 2; D037761:Sirtuins / Q000235:genetics*; D015003:Yeasts / Q000235:genetics* / Q000378:metabolism; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004275:DNA, Ribosomal; D005656:Fungal Proteins; D006655:Histone Deacetylases; D009687:Nuclear Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D000097722:Cohesins; C087778:SIR2 protein, S cerevisiae