CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency.
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
Green
Kathy A
KA
Department of Microbiology and Immunology, 1 Medical Center Dr., Dartmouth Medical School, Lebanon, NH 03750, USA. Kathy.A.Green@dartmouth.edu
Ahonen
Cory L
CL
Cook
W James
WJ
Green
William R
WR
D000818:Animals; D001665:Binding Sites; D019013:CD40 Antigens / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D016183:Murine Acquired Immunodeficiency Syndrome / Q000209:etiology*; D011506:Proteins / Q000502:physiology*; D048029:TNF Receptor-Associated Factor 6
D019013:CD40 Antigens; D011506:Proteins; D048029:TNF Receptor-Associated Factor 6