title: Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4.
abstract: To investigate the association between APOE-epsilon4 allele and memory phenotype in the preclinical stage of Alzheimer's disease (AD). We compared an extensive preclinical memory profile at the baseline evaluation of 2 AD genotype groups: APOE-epsilon4 allele carriers and patients with APOE-epsilon3 homozygosity. Baseline memory performance was carried out at least 2 years (interval of 27.7 +/- 4 months) before AD diagnosis was established, and analysis included different modalities of working memory (visuoperceptive, visuospatial, digit span and processing speed), of declarative memory (recent, verbal learning, prospective and semantic) and of nondeclarative memory (procedural, incidental and priming). We found no significant differences: memory performance was similar in both genotype groups. The presence of the APOE-epsilon4 allele does not seem to be sufficient to cause a distinctive preclinical memory phenotype in AD patients.
authors.affiliation: Department of Neurology, Santa Creu i Sant Pau Hospital, Autonomous University of Barcelona, Barcelona, Spain. 20389aeg@comb.es
authors.forename: Armando
authors.initials: A
authors.lastname: Estévez-González
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Sánchez
authors.forename: Anunciación
authors.initials: A
authors.lastname: Boltes
authors.forename: Pilar
authors.initials: P
authors.lastname: Otermín
authors.forename: Montserrat
authors.initials: M
authors.lastname: Baiget
authors.forename: Antonio
authors.initials: A
authors.lastname: Escartín
authors.forename: Elisabeth
authors.initials: E
authors.lastname: del Rio
authors.forename: Alex
authors.initials: A
authors.lastname: Gironell
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulisevsky
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D000704:Analysis of Variance; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D006720:Homozygote; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008606:Mental Processes / Q000502:physiology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014706:Verbal Learning / Q000502:physiology; D014796:Visual Perception / Q000235:genetics / Q000502:physiology
chemical_list: D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E