Genetic and genomic approaches to identify and study the targets of bioactive small molecules.
Natural and synthetic bioactive small molecules form the backbone of modern therapeutics. These drugs primarily exert their effect by targeting cellular host or foreign proteins that are critical for the progression of disease. Therefore, a crucial step in the process of recognizing valuable new drug leads is identification of their protein targets; this is often a time consuming and difficult task. This report is intended to provide a comprehensive review of recent developments in genetic and genomic approaches to overcome the hurdle of discovering the protein targets of bioactive small molecules.
Zheng
Xiaofeng S
XS
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA. zheng@pathbox.wustl.edu
Chan
Ting-Fung
TF
Zhou
Heather H
HH
D001688:Biological Products / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015195:Drug Design; D020869:Gene Expression Profiling; D016678:Genome; D023281:Genomics / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011485:Protein Binding; D040901:Proteomics / Q000379:methods; D011955:Receptors, Drug / Q000032:analysis*
D001688:Biological Products; D011955:Receptors, Drug