Parasympathetic cardiac nerve stimulation with implanted coronary sinus lead.
A patient with drug-refractory paroxysmal atrial fibrillation associated with rapid ventricular rate underwent biatrial pacemaker implantation. During elective replacement of the pacemaker, a significant voltage- and frequency-dependent decrease in ventricular rate was achieved by high-frequency electrical stimulation (17 Hz) of parasympathetic cardiac nerves innervating the AV node with the implanted bipolar coronary sinus electrode. The negative dromotropic effect of parasympathetic stimulation was eliminated by intravenous administration of 1-mg atropine.
Vágó
Hajnalka
H
Cardiovascular Centre, Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary.
Róka
Attila
A
Acsády
György
G
Merkely
Béla
B
D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D001285:Atropine / Q000008:administration & dosage; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D012849:Sinoatrial Node / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology*; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D001285:Atropine