Using identity-by-descent information in affected sib pairs to increase the efficiency of genetic association studies.
The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families.
Wicks
Jacqueline
J
Queensland Institute of Medical Research, Brisbane, Australia. jackiW@qimr.edu.au
Treloar
Susan A
SA
Martin
Nicholas G
NG
D000483:Alleles; D016022:Case-Control Studies; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D017063:Outcome Assessment, Health Care; D035781:Siblings