[Clinical study of renal blood flow and endothelin in cirrhotic patients].
OBJECTIVE
To find the relationship between hepatic dysfunction and renal blood flow (RBF).


METHODS
49 patients with hepatic cirrhosis were studied via Color-Coded Duplex Ultrasonography detecting the pulsatile index (PI), resistive index (RI), peak systolic velocity (PS), peak diastolic velocity (PD) and peak systolic velocity/peak diastolic velocity (PS/PD) in the interlobar and arcuate arteries. The plasma endothelin (ET) levels were also evaluated.


RESULTS
According to a modified Child's classification which assesses the severity of liver cirrhosis, we compared different groups and found that the worse the function of liver appeared coincidently with the higher PI and RI, especially RI (0.60+/-0.09, 0.66+/-0.06, 0.72+/-0.07, respectively, P < 0.01); The results also indicated that PI, RI increased obviously followed by the rise of ascites (PI: 1.14+/-0.20, 1.31+/-0.29, 1.42+/-0.36, respectively; RI: 0.61+/-0.09, 0.68+/-0.07, 0.77+/-0.05, respectively). The evaluation of plasma ET level demonstrated that its increment is intimately correlated with PI and RI.


CONCLUSIONS
In patients with cirrhosis, RBF is directly correlated with the hepatic function. The correlation between ascites and RBF is also discovered. In patients who have liver cirrhosis, the plasma ET level obviously increased, indicating that ET probably is one of the active factors of renal vascular contraction.
Yan
Yan
Y
Department of Gastroenterology, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.
Zhang
Bo-lun
BL
D000328:Adult; D000368:Aged; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D016232:Endothelins