title: High-resolution fast spin echo imaging of the human brain at 4.7 T: implementation and sequence characteristics.
abstract: In this work, a number of important issues associated with fast spin echo (FSE) imaging of the human brain at 4.7 T are addressed. It is shown that FSE enables the acquisition of images with high resolution and good tissue contrast throughout the brain at high field strength. By employing an echo spacing (ES) of 22 ms, one can use large flip angle refocusing pulses (162 degrees ) and a low acquisition bandwidth (50 kHz) to maximize the signal-to-noise ratio (SNR). A new method of phase encode (PE) ordering (called "feathering") designed to reduce image artifacts is described, and the contributions of RF (B(1)) inhomogeneity, different echo coherence pathways, and magnetization transfer (MT) to FSE signal intensity and contrast are investigated. B(1) inhomogeneity is measured and its effect is shown to be relatively minor for high-field FSE, due to the self-compensating characteristics of the sequence. Thirty-four slice data sets (slice thickness = 2 mm; in-plane resolution = 0.469 mm; acquisition time = 11 min 20 s) from normal volunteers are presented, which allow visualization of brain anatomy in fine detail. This study demonstrates that high-field FSE produces images of the human brain with high spatial resolution, SNR, and tissue contrast, within currently prescribed power deposition guidelines.
authors.affiliation: Wellcome Trust High Field MR Research Laboratory, Department of Medical Physics and Bioengineering, University College London, London, UK. thomas@medphys.ucl.ac.uk
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Enrico
authors.initials: E
authors.lastname: De Vita
authors.forename: Steven
authors.initials: S
authors.lastname: Roberts
authors.forename: Robert
authors.initials: R
authors.lastname: Turner
authors.forename: Tarek A
authors.initials: TA
authors.lastname: Yousry
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Ordidge
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male