title: Amine-salt-controlled, catalytic asymmetric conjugate addition of various amines and asymmetric protonation.
abstract: The combined use of chiral Pd complex 2 and amine salt enabled completely regulated release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric conjugate addition of various amines was achieved to afford beta-amino acid derivatives in high chemical yields with up to 98% ee. Furthermore, a highly enantioselective protonation in 1,4-addition of amine was also developed. [reaction: see text]
authors.affiliation: Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, Katahira, Sendai, Miyagi 980-8577, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Hamashima
authors.forename: Hidenori
authors.initials: H
authors.lastname: Somei
authors.forename: Yuta
authors.initials: Y
authors.lastname: Shimura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tamura
authors.forename: Mikiko
authors.initials: M
authors.lastname: Sodeoka