Antigen presentation by the endothelium: a green light for antigen-specific T cell trafficking?
The functional consequences of recognition of antigen displayed by the endothelium during T cell extravasation in the development of an immune response have been a matter of debate for a long time. Most investigations have focused on the induction of proliferative responses and cytokine production by T cells. In parallel, endothelial cells have been shown to express costimulatory molecules with positive and negative regulatory effects on T cell responses. Recent studies have provided an alternative view of the antigen presenting cell function of endothelial cells, suggesting that cognate recognition of the endothelium by trafficking T cells is a key event in selecting the migration of antigen-specific lymphocytes into the site of inflammation.
Marelli-Berg
Federica M
FM
Department of Immunology, Division of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK. f.marelli@imperial.ac.uk
Jarmin
Sarah J
SJ
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology; D018122:B7-1 Antigen / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002455:Cell Division / Q000276:immunology; D002465:Cell Movement / Q000276:immunology* / Q000502:physiology; D004727:Endothelium / Q000276:immunology*; D006801:Humans; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D015703:Antigens, CD; D018122:B7-1 Antigen