title: Parameningeal rhabdomyosarcoma in a patient with Costello syndrome.
abstract: Costello syndrome, a rare entity with multiple congenital anomalies, has been associated with a high incidence of benign and malignant tumors, particularly rhabdomyosarcoma. Although the head and neck is the most common site for rhabdomyosarcomas in children, only one other case in the literature has been reported of a head and neck rhabdomyosarcoma in a Costello patient. The authors describe a 3-year-old with a parameningeal infratemporal fossa rhabdomyosarcoma. Management is discussed with particular attention to the difficulties encountered due to the congenital heart abnormalities associated with the syndrome.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Geisinger Medical Center, Danville, Pennsylvania 17822-1333, USA. jponeal@geisinger.edu
authors.forename: James Patrick
authors.initials: JP
authors.lastname: O'Neal
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Ramdas
authors.forename: William Edward
authors.initials: WE
authors.lastname: Wood
authors.forename: Phillip Kevin
authors.initials: PK
authors.lastname: Pellitteri
mesh_terms: D000015:Abnormalities, Multiple; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications*; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications; D006801:Humans; D008577:Meningeal Neoplasms / Q000150:complications*; D012208:Rhabdomyosarcoma / Q000150:complications*; D013577:Syndrome