Monocyte chemoattractant protein-1 promoter -2518 polymorphism and schizophrenia in the Korean population.
The purpose of the present study was to investigate the association between the monocyte chemoattractant protein-1 (MCP-1) promoter -2518 polymorphism and schizophrenia. One hundred and twenty-three schizophrenic inpatients and 114 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions in patients with schizophrenia were not significantly different from those of the controls. However, distributions of genotypes and alleles were marginally different when considering subjects with positive and negative symptomatology. The present study therefore calls for further studies on the potential role of the MCP-1 promoter -2518 polymorphism in clinical heterogeneity of schizophrenia.
Pae
Chi-Un
CU
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seocho-Gu, Seoul, Korea.
Chung
Kyoo-In
KI
Kim
Jung-Jin
JJ
Yu
Hye-Sook
HS
Lee
Chang-Uk
CU
Lee
Soo-Jung
SJ
Lee
Chul
C
Jun
Tae-Youn
TY
Serretti
Alessandro
A
Paik
In-Ho
IH
D001483:Base Sequence; D018932:Chemokine CCL2 / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D017931:DNA Primers; D006801:Humans; D007723:Korea; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000235:genetics*; D017384:Sequence Deletion
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D017931:DNA Primers; D004247:DNA