title: Decreased expression of the pancreatic secretory trypsin inhibitor II gene during aging of the rat liver.
abstract: The genetic constitution and differential gene expression of an organism play important roles in controlling the species-specific rate of aging and the maximum life span potential. We utilized a differential-display polymerase chain reaction technique to identify the age-dependent expression of genes in the rat liver. We demonstrate in this report, for the first time, that expression of the pancreatic secretory trypsin inhibitor II (PSTI-II) gene declines drastically during aging. We confirmed this decrease by Northern blot analysis. Low PSTI-II levels in aged animals might result in a lack of protection from prematurely activated trypsin-like proteases, which would thus enhance inflammation.
authors.affiliation: Institute of Life Sciences, Bhubaneswar, India.
authors.forename: Harekrushna
authors.initials: H
authors.lastname: Panda
authors.forename: Ghazala
authors.initials: G
authors.lastname: Zaidi
authors.forename: Prakash C
authors.initials: PC
authors.lastname: Supakar
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000502:physiology; D008099:Liver / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C497897:pancreatic secretory trypsin inhibitor II, rat