Loss of 14q chromosome in oligodendroglial and astrocytic tumors.
Loss of chromosome 14q has been investigated in 142 gliomas. Loss of heterozygosity (LOH) at one or more microsatellite has been found in 8/30 grade II (27%) and 2/21 grade III (10%) oligodendrogliomas, 3/9 grade II (33%) and 5/15 grade III (33%) oligoastrocytomas, 0/9 grade II (0%) and 1/7 grade III (14%) astrocytomas, 11/51 glioblastomas (22%). Two minimal regions were identified on 14q21.2-14q24.3 (between D14S288 and D14S74) and 14q31.3-14q32.1 (between D14S74 and D14S65). Loss of 14q was not correlated to survival, histological grading and subtype or other genetic alterations, except for 1p deletions. Taken together, these data suggest that LOH14q is an early alteration involving 20% of glioma.
Dichamp
Charles
C
Unité' INSERM U495, Paris, France.
Taillibert
Sophie
S
Aguirre-Cruz
Lucinda
L
Lejeune
Julie
J
Marie
Yannick
Y
Kujas
Michèle
M
Delattre
Jean-Yves
JY
Hoang-Xuan
Khe
K
Sanson
Marc
M
D001254:Astrocytoma / Q000235:genetics* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics; D019942:Genes, p16 / Q000502:physiology; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D015996:Survival Rate
D004273:DNA, Neoplasm; D010744:Phosphoric Monoester Hydrolases