title: Solitary spleen metastasis and amyloidosis in a patient with endometrial cancer.
abstract: BACKGROUND
  In contrast to autopsy findings, solitary splenic metastases from solid tumors are extremely rare. It may occasionally be the first manifestation of recurrent solid cancers, and in particular of gynecologic malignancies. Secondary amyloidosis is also found in malignancy.
  
  
  METHODS
  A 52-year-woman originally diagnosed with a Stage IB, grade 2 endometrial carcinoma presented two and a half years later with a paroxysmal non-productive cough, weakness, loss of appetite and daily afternoon fever. On clinical examination wheezing on forced exhalation and painful splenomegaly was found. After an extensive work-up the patient underwent an explorative laparotomy and a splenectomy was performed. Histologic examination showed solitary spleen metastasis with amyloidosis. All symptoms resolved. As the patient had received a full course of postoperative irradiation after a total abdominal hysterectomy, six cycles of combination chemotherapy were administered. The patient remains free of recurrence, 46 months later.
  
  
  CONCLUSIONS
  A case of solitary spleen metastasis with amyloidosis in a patient with endometrial cancer is presented.
authors.affiliation: 1st Department of Medicine, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
authors.forename: H
authors.initials: H
authors.lastname: Gogas
authors.forename: Th
authors.initials: T
authors.lastname: Ignatiadis
authors.forename: Ch
authors.initials: Ch
authors.lastname: Markopoulos
authors.forename: S
authors.initials: S
authors.lastname: Karageorgopoulou
authors.forename: D
authors.initials: D
authors.lastname: Floros
authors.forename: G
authors.initials: G
authors.lastname: Vaiopoulos
mesh_terms: D000686:Amyloidosis / Q000209:etiology*; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D011859:Radiography; D013160:Splenic Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary / Q000628:therapy