title: Loss of 14q chromosome in oligodendroglial and astrocytic tumors.
abstract: Loss of chromosome 14q has been investigated in 142 gliomas. Loss of heterozygosity (LOH) at one or more microsatellite has been found in 8/30 grade II (27%) and 2/21 grade III (10%) oligodendrogliomas, 3/9 grade II (33%) and 5/15 grade III (33%) oligoastrocytomas, 0/9 grade II (0%) and 1/7 grade III (14%) astrocytomas, 11/51 glioblastomas (22%). Two minimal regions were identified on 14q21.2-14q24.3 (between D14S288 and D14S74) and 14q31.3-14q32.1 (between D14S74 and D14S65). Loss of 14q was not correlated to survival, histological grading and subtype or other genetic alterations, except for 1p deletions. Taken together, these data suggest that LOH14q is an early alteration involving 20% of glioma.
authors.affiliation: Unité' INSERM U495, Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Dichamp
authors.forename: Sophie
authors.initials: S
authors.lastname: Taillibert
authors.forename: Lucinda
authors.initials: L
authors.lastname: Aguirre-Cruz
authors.forename: Julie
authors.initials: J
authors.lastname: Lejeune
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marie
authors.forename: Michèle
authors.initials: M
authors.lastname: Kujas
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
authors.forename: Khe
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
mesh_terms: D001254:Astrocytoma / Q000235:genetics* / Q000473:pathology; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics; D019942:Genes, p16 / Q000502:physiology; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000235:genetics* / Q000473:pathology; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics; D015996:Survival Rate
chemical_list: D004273:DNA, Neoplasm; D010744:Phosphoric Monoester Hydrolases