title: Selagoline, a new alkaloid from Huperzia selago.
abstract: A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland. Their structures were determined using 600 and 800MHz one- and two-dimensional NMR methods supported by Fourier-transform mass spectrometry. Possible role of selagoline as a precursor of 5,15-oxidolycopodane, a component of the classical alkaloids L28 and L31, is discussed.
authors.affiliation: Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
authors.forename: Dan
authors.initials: D
authors.lastname: Staerk
authors.forename: Jesper
authors.initials: J
authors.lastname: Larsen
authors.forename: Line A
authors.initials: LA
authors.lastname: Larsen
authors.forename: Elin S
authors.initials: ES
authors.lastname: Olafsdottir
authors.forename: Matthias
authors.initials: M
authors.lastname: Witt
authors.forename: Jerzy W
authors.initials: JW
authors.lastname: Jaroszewski
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D032501:Huperzia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C486661:selagoline; C458904:serratidine; C050426:huperzine A