title: Putative ancestral origins of chromosomal segments in individual african americans: implications for admixture mapping.
abstract: Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative ancestral origin was examined by using haplotypes estimated from genotyping 268 African Americans for 29 ancestry informative markers spaced over a 60-cM segment of chromosome 5. Analyses using a Bayesian algorithm (STRUCTURE) provided evidence that blocks of individual chromosomes derive from one or the other parental population. In addition, modeling studies were performed by using hidden real marker data to simulate patient and control populations under different genotypic risk ratios. Ancestry analysis showed significant results for a genotypic risk ratio of 2.5 in the African American population for modeled susceptibility genes derived from either putative parental population. These studies suggest that admixture mapping in the African American population can provide a powerful approach to defining genetic factors for some disease phenotypes.
authors.affiliation: Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California at Davis, Davis, California 95616-8669, USA. mfseldin@ucdavis.edu
authors.forename: Michael F
authors.initials: MF
authors.lastname: Seldin
authors.forename: Takanobu
authors.initials: T
authors.lastname: Morii
authors.forename: Heather E
authors.initials: HE
authors.lastname: Collins-Schramm
authors.forename: Bill
authors.initials: B
authors.lastname: Chima
authors.forename: Rick
authors.initials: R
authors.lastname: Kittles
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Criswell
authors.forename: Hongzhe
authors.initials: H
authors.lastname: Li
mesh_terms: D001741:Black or African American / Q000208:ethnology / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003198:Computer Simulation; D005006:Ethnicity / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005828:Genetics, Population; D005838:Genotype; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D044465:White People / Q000235:genetics*
chemical_list: D005819:Genetic Markers