Phytochemical and antiinflammatory studies on Terminalia catappa.
The antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the antiinflammatory activity of T. catappa leaves.
Fan
Y M
YM
Institute of Materia Medica, Nanjing University School of Medicine, Nanjing 210093, PR China.
Xu
L Z
LZ
Gao
J
J
Wang
Y
Y
Tang
X H
XH
Zhao
X N
XN
Zhang
Z X
ZX
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D029766:Terminalia; D013755:Tetradecanoylphorbol Acetate
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate