[Effect of intraoperative using cell saver on blood sparing and its impact on coagulation function].
OBJECTIVE
To observe the effectiveness of using cell saver (CS) during surgery on blood sparing and its impact on patient's hematology and coagulation function.


METHODS
One-hundred and thirty-eight patients undergoing elective surgery were recruited for intraoperative blood salvage using CS. Blood routine, blood chemistry and coagulation function were measured before surgery, after infusion of salvaged blood and postoperative day 1, respectively.


RESULTS
In total, 112,056 ml of packed red blood cells were collected, with a mean value of 812 ml per patient. The percentage of autologous blood transfusion volume to the total blood transfusion volume was from 48% to 89%. Allogenic blood transfusion rate was from 5% to 100%. Compared with the values before surgery, the hemoglobin concentration, platelet count, plasma total protein and fibrinogen concentration decreased significantly after the transfusion of salvaged blood and the first postoperative day (P < 0.05 or P < 0.01), while the prothrombin time was significantly prolonged (P < 0.05).


CONCLUSIONS
The use of CS during surgery can, to a certain extent, reduce the requirement of allogenic blood. However, reinfusion of large amount of salvaged blood may affect coagulation function.
Guo
Xiang-yang
XY
Department of Anaesthesia, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. xyg34@hotmail.com
Duan
He
H
Wang
Jing-jie
JJ
Luo
Ai-lun
AL
Ye
Tie-hu
TH
Huang
Yu-guang
YG
Ren
Hong-zhi
HZ
D000328:Adult; D000368:Aged; D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous / Q000379:methods*; D001810:Blood Volume; D001026:Coronary Artery Bypass; D017558:Elective Surgical Procedures; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time