[The significance of urine di-acetyl spermine level as a cancer marker for colorectal cancer].
We analyzed the significance of the measurement of urine di-acetyl spermine (DiAcSpm) as a cancer marker for colorectal cancer treatment. We measured both the urine DiAcSpm(ELISA, normal range: 0-0.25 mumol/creatinine) and serum CEA (normal range: 0-5.0 ng/ml) of preoperative and postoperative colorectal cancer patients every month. We compared the positive rate from the cancer stage and the power of prognostic prediction. We divided the colorectal cancer patients into 4 groups: Group A: both levels were high; Group B: only the CEA level was high; Group C: only the DiAcSpm level was high; Group D: both levels were within a normal range. The positive rates of DiAcSpm and CEA from cancer staging were as follows: Stage 0: 62% and 9.5%, Stage I: 60% and 10%, Stage II: 70% and 42%, Stage III: 82% and 47%, and Stage IV: 88% and 63%, respectively. There was a significant difference (p < 0.0001) between both levels, especially for early-stage cases. The two-year survival rate was 0% in Group A, 100% in Group B, 72.7% in Group C and 100% in Group D. The difference among the 4 groups was significant (p < 0.0001). This showed that urine DiAcSpm predicted the prognosis after colorectal cancer surgery more exactly than serum CEA.
Takahashi
Keiichi
K
Department of Surgery, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Tokyo 113-8677.
Hiramatsu
Kyoko
K
Kawakita
Masao
M
Mori
Takeo
T
Yamaguchi
Tatsuro
T
Matsumoto
Hiroshi
H
Miyamoto
Hidenori
H
Tamamori
Yoshiko
Y
D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine*; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D013096:Spermine / Q000031:analogs & derivatives* / Q000652:urine*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D013096:Spermine; C029453:N',N''-diacetylspermine