Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.
The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described.
Sendzik
Martin
M
Departments of Medicinal Chemistry and Biology, Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. martin.sendzik@celera.com
Janc
James W
JW
Cabuslay
Ronnel
R
Honigberg
Lee
L
Mackman
Richard L
RL
Magill
Catherine
C
Squires
Neil
N
Waldeck
Nancy
N
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000626:Aminopeptidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D002417:Cattle; D015195:Drug Design; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology*; D006023:Glycoproteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D063208:Methionyl Aminopeptidases; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
D000577:Amides; D006023:Glycoproteins; D011480:Protease Inhibitors; D000626:Aminopeptidases; C081311:METAP2 protein, human; D063208:Methionyl Aminopeptidases