Synthesis of 4-fluorinated UDP-MurNAc pentapeptide as an inhibitor of bacterial growth.
4-Fluorinated UDP-MurNAc pentapeptide, 2, has been synthesized. In our previous study, UDP-MurNAc pentapeptide analogue 1 was found to be incorporated into the bacterial cell wall through biosynthesis. Compound 2 showed growth-inhibition activity against Gram-positive bacteria when it was added to growth media at 0.01 mg/mL. [structure--see text]
Ueda
Taichi
T
Bio-Macromolecular Chemistry Lab, Division of Biological Sciences, Graduate School of Science, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University, Kita 21, Nishi 11, Sapporo 001-0021 Japan.
Feng
Fei
F
Sadamoto
Reiko
R
Niikura
Kenichi
K
Monde
Kenji
K
Nishimura
Shin-Ichiro
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development*; D002455:Cell Division / Q000187:drug effects; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009842:Oligopeptides