A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ.
The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented.
Reynolds
R C
RC
Drug Discovery Division, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL 35205, USA. reynolds@sri.org
Srivastava
S
S
Ross
L J
LJ
Suling
W J
WJ
White
E L
EL
D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D011621:Pteridines / Q000737:chemistry* / Q000494:pharmacology*
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; C071525:FtsZ protein, Bacteria; D011621:Pteridines