Pulmonary dysfunction in pediatric oncology patients.
Children suffering from cancer may experience short episodes of respiratory distress and/or chronic impairment in pulmonary function. Pulmonary dysfunction may be primarily disease-related, but it may also result secondarily from treatment. Emergencies with critical respiratory dysfunction in childhood cancer include mechanical obstruction of vital anatomical structures and hyperleukocytosis syndrome. This paper focuses on the most relevant causes of respiratory distress and lung injury in pediatric oncology patients and bone marrow transplant patients. Infectious causes, lung disease resulting from anti-neoplastic agents, and bone marrow transplant-related pulmonary dysfunction are emphasized. A review of the literature pertinent to this subject is given.
Meyer
Sascha
S
Department of Pediatric Oncology, University Hospital of the Saarland, Kirrbergerstr. 66421 Homburg/Saar, Germany. sascha.meyer@uniklinik-saarland.de
Reinhard
Harald
H
Gottschling
Sven
S
Nunold
Holger
H
Graf
Norbert
N
D000970:Antineoplastic Agents / Q000009:adverse effects; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D004417:Dyspnea / Q000209:etiology; D006801:Humans; D007049:Iatrogenic Disease; D007239:Infections / Q000209:etiology; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology*; D009369:Neoplasms / Q000150:complications* / Q000628:therapy
D000970:Antineoplastic Agents