[Comparative assessment of efficacy of tissue plasminogen activator and streptokinase in the treatment of patients with acute myocardial infarction].
OBJECTIVE
To compare results of treatment of patients with acute myocardial infarction with tissue plasminogen activator (TPA) and streptokinase.


METHODS
TPA (100 mg intravenously) and streptokinase (1500000 U intravenously) were used for thrombolytic therapy of acute myocardial infarction in 114 and 118 patients, respectively.


RESULTS
TPA treated compared with streptokinase treated patients were characterized by less frequent serious cardiac rhythm and conduction disturbances and hypotension during thrombolysis (p<0.05), as well as less frequent pathological Q-waves formation (p<0.001). More than 50% lowering of initially elevated ST-segment by 90-th minute occurred more often in TPA treated patients (p<0.001). Differences between TPA and streptokinase treated patients in mortality (3.5 and 7.6%, respectively), reinfarction rate during first 24 hours (3.5 and 5.1%, respectively), aneurysm formation (9.1 and 14.7%, respectively), and heart failure development (4.5 and 11.0%, respectively) were not significant.


CONCLUSIONS
The use of TPA for thrombolytic therapy of patients with acute myocardial infarction gave better results than the use of streptokinase.
Shul'man
V A
VA
Krasnoyarsk State Medical Academy; Hospital #20; Etergency Hospital; Regional Hospital #1.
Radionov
V V
VV
Golovenkin
S E
SE
Pediashov
V E
VE
Linev
K A
KA
Titarenko
O M
OM
Simulin
V N
VN
Pasal'skiĭ
V L
VL
Peterson
L S
LS
Necheporenko
G I
GI
Kononova
L I
LI
Peterson
E V
EV
D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy; D015425:Myocardial Reperfusion; D013300:Streptokinase / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
D013300:Streptokinase; D010959:Tissue Plasminogen Activator