title: Microcirculatory efficacy of topical treatment with aescin + essential phospholipids gel on transcutaneous PO2 in venous insufficiency.
abstract: A gel including aescin, essential phospholipids (EPL), and heparin (EG) has been used for many years for local treatment of venous, microcirculatory alterations (varicose veins, chronic venous insufficiency). Bruises, swelling, thrombophlebitis, and contusions are effectively treated with this compound. The aim of this study was the evaluation of the efficacy of the effects of an AEPL (aescin+EPL) gel on the microcirculation in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Transcutaneous PO(2) was measured at the perimalleolar region. After 2 weeks of treatment, all individual values (100%) were significantly increased (p < 0.05). In all patients, PO(2) increased, indicating a decrease in level of venous microangiopathy. Considering transcutaneous skin PO(2), treatment with AEPL in areas of venous microangiopathy is beneficial in the prevention of ulceration and improves skin healing.
authors.affiliation: Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: E
authors.initials: E
authors.lastname: Ippolito
authors.forename: A
authors.initials: A
authors.lastname: Ricci
authors.forename: M
authors.initials: M
authors.lastname: Ruffini
authors.forename: M
authors.initials: M
authors.lastname: Dugall
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001785:Blood Gas Monitoring, Transcutaneous; D004338:Drug Combinations; D004928:Escin / Q000008:administration & dosage*; D005260:Female; D005782:Gels; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D014689:Venous Insufficiency / Q000097:blood / Q000188:drug therapy*; D014690:Venous Pressure
chemical_list: D004338:Drug Combinations; D005782:Gels; D010713:Phosphatidylcholines; C011246:essential 303 forte; D004928:Escin; D010100:Oxygen