title: The effect of donor weight reduction on hepatic steatosis for living donor liver transplantation.
abstract: Hepatic steatosis is often associated with overweight, so we tried body-weight reduction in potential living donors with fatty liver and/or obesity to alleviate hepatic steatosis. We advised to reducing the body weight by 5% for 9 potential living donors showing hepatic steatosis of 25-95% on initial percutaneous needle biopsy (PCNB). They lost 5.9 +/- 2.0% of the initial body weight during 2-6 months and their body mass index changed from 25.3 +/- 3.8 to 23.7 +/- 3.4. Total amount of hepatic steatosis changed significantly from 48.9 +/- 25.6% to 20.0 +/- 16.2% before and after weight reduction. The proportional reduction in microvesicular steatosis was more obvious than in macrovesicular fatty changes. Six right lobe and 3 left lobe grafts were procured uneventfully from these 9 donors. All donors recovered uneventfully, and all 9 recipients survived more than 15 months to date. In conclusion, we think that short-term weight reduction of living donors will be helpful to alleviate excessive hepatic steatosis, especially in microvesicular type and can contribute to expand the pool of marginal living donors.
authors.affiliation: Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Shin
authors.initials: S
authors.lastname: Hwang
authors.forename: Sung-Gyu
authors.initials: SG
authors.lastname: Lee
authors.forename: Se-Jin
authors.initials: SJ
authors.lastname: Jang
authors.forename: Sung-Hun
authors.initials: SH
authors.lastname: Cho
authors.forename: Ki-Hun
authors.initials: KH
authors.lastname: Kim
authors.forename: Chul-Soo
authors.initials: CS
authors.lastname: Ahn
authors.forename: Deok-Bog
authors.initials: DB
authors.lastname: Moon
authors.forename: Tae-Yong
authors.initials: TY
authors.lastname: Ha
mesh_terms: D001706:Biopsy; D015992:Body Mass Index; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D015431:Weight Loss