A comparison of the hormone levels in patients with Sjogren's syndrome and healthy controls.
OBJECTIVE
The purpose of this study was to compare the level and relative ratio of estrogen, progesterone, and prolactin in patients with Sjögren's syndrome and healthy controls.


METHODS
Serum samples were collected from 17 SS patients and 19 age-, sex- and race-matched controls. All subjects were postmenopausal females who were not currently on hormone replacement therapy. Prolactin levels were measured using ELISA and progesterone and estrogen were measured using EIA.


RESULTS
Mann-Whitney U test revealed a significantly higher levels of prolactin among patients than controls (11.41 ng/ml vs. 6.74 ng/ml, p=0.003) with significantly higher prolactin/ progesterone (18.88 vs. 8.14, p=0.02) and estrogen/ progesterone (71.51 vs. 42.02, p=0.05) ratios. No significant differences were observed in the levels of estrogen and progesterone between patients and controls.


CONCLUSIONS
Abnormal levels and relative ratios of hormones may play a role in the pathogenesis of Sjögren's syndrome.
Taiym
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Department of Periodontics, Baylor College of Dentistry, Texas A&M University System, Dallas, 75246, USA.
Haghighat
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N
Al-Hashimi
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I
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004967:Estrogens / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D011374:Progesterone / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D012859:Sjogren's Syndrome / Q000097:blood* / Q000145:classification; D018709:Statistics, Nonparametric
D004967:Estrogens; D011374:Progesterone; D011388:Prolactin