Cytogenetic studies in mice treated with the jet fuels, Jet-A and JP-8.
The genotoxic potential of the jet fuels, Jet-A and JP-8, were examined in mice treated on the skin with a single dose of 240 mg/mouse. Peripheral blood smears were prepared at the start of the experiment (t = 0), and at 24, 48 and 72 h following treatment with jet fuels. Femoral bone marrow smears were made when all animals were sacrificed at 72 h. In both tissues, the extent of genotoxicity was determined from the incidence of micronuclei (MN) in polychromatic erythrocytes. The frequency of MN in the peripheral blood of mice treated with Jet-A and JP-8 increased over time and reached statistical significance at 72 h, as compared with concurrent control animals. The incidence of MN was also higher in bone marrow cells of mice exposed to Jet-A and JP-8 as compared with controls. Thus, at the dose tested, a small but significant genotoxic effect of jet fuels was observed in the blood and bone marrow cells of mice treated on the skin.
Vijayalaxmi
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Department of Radiation Oncology, The University of Texas Health Science Center, San Antonio, TX 78229, USA. vijay@uthscsa.edu
Kligerman
A D
AD
Prihoda
T J
TJ
Ullrich
S E
SE
D000279:Administration, Cutaneous; D000818:Animals; D001773:Blood Cells / Q000187:drug effects / Q000648:ultrastructure; D001854:Bone Marrow Cells / Q000187:drug effects / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004913:Erythrocytes, Abnormal / Q000187:drug effects; D005260:Female; D005579:Fossil Fuels / Q000633:toxicity*; D006838:Hydrocarbons / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D008809:Mice, Inbred C3H; D015162:Micronucleus Tests; D011897:Random Allocation; D016037:Single-Blind Method; D013047:Specific Pathogen-Free Organisms; D013194:Staining and Labeling
D005579:Fossil Fuels; D006838:Hydrocarbons; C098607:JP8 aviation fuel; D003520:Cyclophosphamide