Elevated triiodothyronine in psychopathy - possible physiological mechanisms.
We assessed a total range of peripheral thyroid hormone fractions, binding globulins, and thyroid-active antibodies in 37 medication-free, violent or sexual offenders, aged 17-45 years, to describe possible mechanisms involved in the thyroid metabolism of aggressive men. The ratio between T3 and T4 correlated with ratings of psychopathy, indicating increased peripheral deiodination as a biological covariate to callous personality traits. Autoimmune antibodies, hepatic failure, abnormal binding globulins, or substance abuse did not affect the association.
Soderstrom
H
H
National Board of Forensic Medicine, Department of Forensic Psychiatry, Göteborg, Sweden. henrik.soderstrom@rmv.se
Forsman
A
A
D000293:Adolescent; D000328:Adult; D000987:Antisocial Personality Disorder / Q000097:blood*; D006801:Humans; D007118:Immunoassay; D008111:Liver Function Tests; D008297:Male; D013961:Thyroid Gland / Q000502:physiology*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013974:Thyroxine