title: Drug delivery devices based on mesoporous silicate.
abstract: A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its characterization by X-ray, N2 absorption-desorption isotherm, and thermogravimetry analysis have been described. Drug loading was performed by a soaking procedure. Drug-loaded matrices were characterized for entrapped drug amount, water absorption ability, and thermogravimetric behavior. Drug release studies also were performed at pH 1.1 and 6.8 mimicking gastrointestinal fluids. Experimental results showed that this type of matrix is able to trap the bioactive agents by a soaking procedure and, then, to release them in conditions mimicking the biological fluids. Also, the high affinity of these matrices for water makes them potentially biocompatible. Release data suggest that the matrix impregnated with diflunisal offers good potential as a system for the modified drug release.
authors.affiliation: Dipartimento di Chimica e Tecnologie Farmaceutiche, Palermo, Italy. gennacav@unipa.it
authors.forename: Gennara
authors.initials: G
authors.lastname: Cavallaro
authors.forename: Paola
authors.initials: P
authors.lastname: Pierro
authors.forename: Fabio Salvatore
authors.initials: FS
authors.lastname: Palumbo
authors.forename: Flaviano
authors.initials: F
authors.lastname: Testa
authors.forename: Luigi
authors.initials: L
authors.lastname: Pasqua
authors.forename: Rosario
authors.initials: R
authors.lastname: Aiello
mesh_terms: D000327:Adsorption / Q000187:drug effects; D000535:Aluminum / Q000737:chemistry; D000538:Aluminum Silicates / Q000138:chemical synthesis / Q000737:chemistry*; D004061:Diflunisal / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004355:Drug Stability; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D008422:Materials Testing; D009288:Naproxen / Q000008:administration & dosage / Q000493:pharmacokinetics; D009584:Nitrogen / Q000737:chemistry; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity / Q000187:drug effects*; D012995:Solubility; D013818:Thermogravimetry / Q000379:methods; D014867:Water; D014965:X-Rays
chemical_list: D000538:Aluminum Silicates; D017646:Organosilicon Compounds; D014867:Water; C049037:aluminosilicate; D009288:Naproxen; D004061:Diflunisal; D000535:Aluminum; D009584:Nitrogen; D007052:Ibuprofen