The therapeutic potential of ximelagatran to become the anticoagulant of choice in medicine: a review of recently completed clinical trials.
Ximelagatran (Exanta, AstraZeneca) is a novel oral direct thrombin inhibitor that inhibits the final step in the coagulation process - namely, the conversion of fibrinogen to insoluble fibrin by thrombin. Recently completed large clinical trials have evaluated the efficacy and safety of ximelagatran compared to standard anticoagulation therapy with warfarin and heparins in several thrombotic disorders including the treatment and prevention of venous thromboembolism following major orthopaedic surgery; stroke prevention in atrial fibrillation; and after acute myocardial infarction. This article reviews these recent clinical trials and explores the therapeutic potential of ximelagatran to become the oral anticoagulant of first choice in medicine.
Salam
Amar M
AM
Hamad Medical Corporation, Department of Cardiology and Cardiovascular Surgery, PO Box 3050, Doha, Qatar. amaramin@yahoo.com
Al-Mousa
Eyas N
EN
D000925:Anticoagulants / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications; D001384:Azetidines / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D001596:Benzylamines; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005998:Glycine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D011355:Prodrugs / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use; D020521:Stroke / Q000209:etiology / Q000517:prevention & control; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013923:Thromboembolism / Q000188:drug therapy; D020246:Venous Thrombosis / Q000188:drug therapy
D000925:Anticoagulants; D001384:Azetidines; D001596:Benzylamines; D011355:Prodrugs; C109573:melagatran; C426686:ximelagatran; D013917:Thrombin; D005998:Glycine