Changes in type B natriuretic peptide (BNP) concentrations during cardiac valve replacement.
OBJECTIVE
The aim of our study was to investigate the ability of BNP levels to reveal the immediate post-surgery cardiac function improvement. We measured the perioperative variations in BNP concentrations in patients scheduled for cardiac surgery with cardiopulmonary bypass (CPB), chronic mitral regurgitation, valvular aortic stenosis, or myocardial ischaemia.


METHODS
Three groups were included: patients with coronary artery bypass graft (CABG, group I, n = 14), aortic (AVR, group II, n = 14) or mitral (MVR, group III, n = 7) valve replacement. BNP assay was performed at the induction of anesthesia, immediately after the CPB, at the arrival in the intensive care unit, 4 h, 8 h and 12 h after the arrival in ICU.


CONCLUSIONS
The occurring variation in BNP levels after the operation is an increase whatever the corrective surgery, underlying the relative lack of specificity of BNP with regard to the cardiac pathology. Besides iatrogenic cardioplegia one can supposes that cardiac surgery involves other major stimuli such as anesthesia, sternotomia, hemodynamics, post-operative that could influence in a non specific way BNP levels.
Georges
A
A
Nuclear Medicine Department, Hôpital Haut-Lévêque, Avenue Magellan, 33604 Pessac, Cedex, France. agnes.georges@chu-bordeaux.fr
Forestier
F
F
Valli
N
N
Plogin
A
A
Janvier
G
G
Bordenave
L
L
D000368:Aged; D001024:Aortic Valve Stenosis / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000601:surgery; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011184:Postoperative Period; D011446:Prospective Studies
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain