title: A population-based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster sampling.
abstract: BACKGROUND
  The detailed population-based data on irritable bowel syndrome in South China are lacking.
  
  
  OBJECTIVE
  To assess the prevalence of irritable bowel syndrome in South China and its impact on health-related quality of life.
  
  
  METHODS
  A face-to-face interview was carried out in South China to assess the prevalence of irritable bowel syndrome. Random clustered sampling of permanent inhabitants aged 18-80 years was carried out under stratification of urban and suburban areas. The impact of irritable bowel syndrome on health-related quality of life was evaluated using the Chinese version of SF-36.
  
  
  RESULTS
  A total of 4178 subjects (1907 male and 2271 female) were interviewed. The adjusted prevalence of irritable bowel syndrome in South China is 11.50% according to the Manning criteria and 5.67% according to the Rome II criteria. Factors including history of analgesic use such as non-steroidal anti-inflammatory drug (odds ratio 3.83), history of food allergies (odds ratio 2.68), psychological distress (odds ratio 2.18), life events (odds ratio 1.89), history of dysentery (odds ratio 1.63) and negative coping style (odds ratio 1.28) were significantly associated with the presence of irritable bowel syndrome (P < 0.05). Irritable bowel syndrome was significantly associated with a decrement in health-related quality of life score.
  
  
  CONCLUSIONS
  Irritable bowel syndrome is a common disorder in South China and has a negative impact on health-related quality of life.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, SunYat-Sen University, Guangzhou, China.
authors.forename: L S
authors.initials: LS
authors.lastname: Xiong
authors.forename: M H
authors.initials: MH
authors.lastname: Chen
authors.forename: H X
authors.initials: HX
authors.lastname: Chen
authors.forename: A G
authors.initials: AG
authors.lastname: Xu
authors.forename: W A
authors.initials: WA
authors.lastname: Wang
authors.forename: P J
authors.initials: PJ
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003109:Colonic Diseases, Functional / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D015995:Prevalence; D011788:Quality of Life; D012307:Risk Factors; D011795:Surveys and Questionnaires