title: 1,7-annulated indolocarbazoles as cyclin-dependent kinase inhibitors.
abstract: The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.
authors.affiliation: Discovery Chemistry Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. rima@lilly.com
authors.forename: Rima S
authors.initials: RS
authors.lastname: Al-awar
authors.forename: James E
authors.initials: JE
authors.lastname: Ray
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Hecker
authors.forename: Jianping
authors.initials: J
authors.lastname: Huang
authors.forename: Philip P
authors.initials: PP
authors.lastname: Waid
authors.forename: Chuan
authors.initials: C
authors.lastname: Shih
authors.forename: Harold B
authors.initials: HB
authors.lastname: Brooks
authors.forename: Charles D
authors.initials: CD
authors.lastname: Spencer
authors.forename: Scott A
authors.initials: SA
authors.lastname: Watkins
authors.forename: Bharvin R
authors.initials: BR
authors.lastname: Patel
authors.forename: Nancy B
authors.initials: NB
authors.lastname: Stamm
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Ogg
authors.forename: Richard M
authors.initials: RM
authors.lastname: Schultz
authors.forename: Eileen L
authors.initials: EL
authors.lastname: Considine
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Faul
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Sullivan
authors.forename: Stanley P
authors.initials: SP
authors.lastname: Kolis
authors.forename: John L
authors.initials: JL
authors.lastname: Grutsch
authors.forename: Sajan
authors.initials: S
authors.lastname: Joseph
mesh_terms: D002227:Carbazoles / Q000737:chemistry* / Q000494:pharmacology; D019938:Cyclin D1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D002227:Carbazoles; D007211:Indoles; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D019938:Cyclin D1; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases