title: [Ultrasound microbubbles promote thrombolysis of rabbit femoral artery thrombus].
abstract: OBJECTIVE
  To evaluate the efficacy of intravenous ultrasound microbubbles for thrombolysis of arterial thrombus without using thrombolytic drugs.
  
  
  METHODS
  Twelve rabbit models of acute bilateral femoral artery thrombosis were established and 6 of them received transcutaneous ultrasound and intravenous albumin microbubble treatment for thrombosis on one side while only microbubble treatment for the other side. The other 6 rabbits received ultrasound treatment on one side but no treatment on the other to serve as the control group.
  
  
  RESULTS
  None of the 6 arteries treated with microbubbles alone and only 2 arteries treated with ultrasound alone in the 6 control rabbits were recanalized. All the 6 femoral arteries treated with microbubbles together with ultrasound were recanalized (P=0.014), with significantly shorter patent time and smaller residual thrombus cross-sectional area than those of the arteries with only ultrasound treatment (P=0.004 and P=0.003, respectively).
  
  
  CONCLUSIONS
  Treatment with intravenous microbubbles assisted by transcutaneous ultrasound effectively promotes arterial thrombolysis in vivo, and this technique can be of significance in clinical treatment of acute thrombotic occlusions.
authors.affiliation: Department of Cardiology, Nangfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Wen-chao
authors.initials: WC
authors.lastname: Ou
authors.forename: Jian-cheng
authors.initials: JC
authors.lastname: Xiu
authors.forename: Jin-guo
authors.initials: JG
authors.lastname: Xie
authors.forename: Dao-gang
authors.initials: DG
authors.lastname: Zha
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Hao
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Bin
authors.forename: Yi-li
authors.initials: YL
authors.lastname: Liu
mesh_terms: D000818:Animals; D005260:Female; D005263:Femoral Artery; D008297:Male; D011817:Rabbits; D013927:Thrombosis / Q000628:therapy*; D014464:Ultrasonic Therapy / Q000379:methods*