Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans.
Family and twin studies have indicated that genes influence susceptibility to panic disorder, but the genes involved remain unknown. The neuropeptide angiotensin II has been found to be involved in anxiety and regulation of respiration which are important in the pathophysiology of panic attacks. Assuming that angiotensins may be candidate genes in panic disorder, we analyzed the association between panic disorder and angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) gene functional polymorphism. We recruited 101 patients with panic disorder diagnosed according to DSM-IV criteria, and 184 control subjects in the study. No significant differences in the frequency of the genotype or allele in the polymorphism between patient and control groups were found (genotype, chi(2)=0.56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group.
Shimizu
Eiji
E
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. eiji@faculty.chiba-u.jp
Hashimoto
Kenji
K
Kobayashi
Keisuke
K
Mitsumori
Makoto
M
Ohgake
Shintaro
S
Koizumi
Hiroki
H
Okamura
Naoe
N
Koike
Kaori
K
Kumakiri
Chikara
C
Nakazato
Michiko
M
Komatsu
Naoya
N
Iyo
Masaomi
M
D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D016584:Panic Disorder / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
D007703:Peptidyl-Dipeptidase A