title: Diagnostic use of serum deoxyribonuclease I activity as a novel early-phase marker in acute myocardial infarction.
abstract: BACKGROUND
  The delayed release of serum cardiac markers such as creatine kinase isoenzyme MB and equivocal early electrocardiographic changes have hampered a diagnosis of acute myocardial infarction (AMI) in the early phase after its onset. Therefore, a reliable serum biochemical marker for the diagnosis of AMI in the very early phase is desirable.
  
  
  RESULTS
  Serum samples were collected from the patients with AMI, unstable angina pectoris, stable angina pectoris, and other diseases. Levels of serum deoxyribonuclease I (DNase I) activity in the patients were determined. An abrupt elevation of serum DNase I activity was observed within approximately 3 hours of the onset of symptoms in patients with AMI, with significantly higher activity levels (21.7+/-5.10 U/L) in this group compared with the other groups with unstable angina pectoris (10.4+/-4.41 U/L), angina pectoris (10.8+/-3.70 U/L), and other diseases (9.22+/-4.16 U/L). Levels of the DNase I activity in serum then exhibited a marked time-dependent decline within 12 hours and had returned to basal levels within 24 hours.
  
  
  CONCLUSIONS
  We suggest that serum DNase I activity could be used as a new diagnostic marker for the early detection of AMI.
authors.affiliation: Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kawai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Arakawa
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Kumamoto
authors.forename: Norihiro
authors.initials: N
authors.lastname: Morikawa
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Masamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tada
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshizaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oshima
authors.forename: Koichi
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Terasawa
authors.forename: Isamu
authors.initials: I
authors.lastname: Miyamori
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kishi
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yasuda
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000175:diagnosis; D003850:Deoxyribonuclease I / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*
chemical_list: D015415:Biomarkers; D003850:Deoxyribonuclease I