Nonsense-mediated mRNA decay: terminating erroneous gene expression.
Nonsense-mediated mRNA decay is a surveillance pathway that reduces errors in gene expression by eliminating aberrant mRNAs that encode incomplete polypeptides. Recent experiments suggest a working model whereby premature and normal translation termination events are distinct as a consequence of the spatial relationship between the termination codon and mRNA binding proteins, a relationship partially established by nuclear pre-mRNA processing. Aberrant termination then leads to both translational repression and an increased susceptibility of the mRNA to multiple ribonucleases.
Baker
Kristian E
KE
Howard Hughes Medical Institute, University of Arizona, 1007 East Lowell Street, Tucson, Arizona 85721, USA.
Parker
Roy
R
D020413:3' Untranslated Regions; D000818:Animals; D018389:Codon, Nonsense; D018388:Codon, Terminator; D015870:Gene Expression; D006801:Humans; D014176:Protein Biosynthesis / Q000235:genetics; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D014158:Transcription, Genetic
D020413:3' Untranslated Regions; D018389:Codon, Nonsense; D018388:Codon, Terminator; D012333:RNA, Messenger; D016601:RNA-Binding Proteins