[Pharmacodynamics of nonessential amino acids in elderly patients with post-infarction cardiac sclerosis].
We studied pharmacodynamics of an amino acids complex (AAC) in 60 elderly patients (a mean age 71.6 years) with ischemic heart disease, postinfarction cardiosclerosis (PIC), circulatory insufficiency stage I-II. The patients were randomized into 3 groups, 20 persons each. Group 1 received standard therapy (ST) and placebo, group 2--ST + AAC (one tablet of 70 mg 3 times a day), group 3--ST + AAC sublingually in the same dose. Clinical symptoms, results of ECG Holter monitoring and echocardiography were assessed before the treatment and on treatment day 18. Positive effects of AAC used in combination with ST in relation to clinical symptoms, myocardial contractility and ischemia. No differences in efficacy were observed with oral and sublingual AAC administration.
Zaslavskaia
R M
RM
Lilitsa
G V
GV
Teĭblium
M M
MM
Goncharov
L F
LF
D000284:Administration, Oral; D000286:Administration, Sublingual; D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage* / Q000494:pharmacology*; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D012598:Sclerosis / Q000188:drug therapy; D016896:Treatment Outcome
D000596:Amino Acids