In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.
A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive lipase, an enzyme of potential importance in the treatment of diabetes.
Lowe
Derek B
DB
Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. derek.lowe.b@bayer.com
Magnuson
Steven
S
Qi
Ning
N
Campbell
Ann-Marie
AM
Cook
James
J
Hong
Zhenqiu
Z
Wang
Ming
M
Rodriguez
Mareli
M
Achebe
Furahi
F
Kluender
Harold
H
Wong
Wai C
WC
Bullock
William H
WH
Salhanick
Arthur I
AI
Witman-Jones
Terri
T
Bowling
Mary E
ME
Keiper
Christine
C
Clairmont
Kevin B
KB
D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology; D007555:Isoxazoles / Q000737:chemistry* / Q000494:pharmacology; D002787:Sterol Esterase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007555:Isoxazoles; D014508:Urea; D002787:Sterol Esterase