title: Nuclear factor-kappaB p65 is a prognostic indicator in gastric carcinoma.
abstract: BACKGROUND
  In common with other investigators, we have reported the constitutive activation of transcription factor nuclear factor-kappaB (NF-kappaB) in a variety of carcinomas, but there is no definite information on its clinical significance.
  
  
  METHODS
  NF-kappaB p65 activation was determined by immunohistochemical analysis of surgically resected specimens from 63 gastric carcinomas. The 63 patients were divided into a high NF-kappaB group (21 patients) and a low NF-kappaB group (42 patients). Forty-seven of the 63 patients underwent curative resection. The 47 patients consisted of 13 high NF-kappaB patients and 34 low NF-kappaB patients.
  
  
  RESULTS
  The high NF-kappaB group demonstrated a shorter overall survival rate compared with the low NF-kappaB group (p=0.015). In the 47 patients who underwent curative resection, the high NF-kappaB group also showed a poor survival prognosis (p=0.032). Multivariate analysis indicated that NF-kappaB activation is a potential prognostic factor in gastric carcinoma.
  
  
  CONCLUSIONS
  Constitutive activation of NF-kappaB p65 may be a new prognostic parameter in gastric carcinoma.
authors.affiliation: Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Yamanaka
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Sasaki
authors.forename: Akira
authors.initials: A
authors.lastname: Tasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakashima
authors.forename: Makoto
authors.initials: M
authors.lastname: Kubo
authors.forename: Takashi
authors.initials: T
authors.lastname: Morisaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Noshiro
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Katano
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D051996:Transcription Factor RelA
chemical_list: D014408:Biomarkers, Tumor; D016328:NF-kappa B; D051996:Transcription Factor RelA