title: First total synthesis of structurally unique flavonoids and their strong anti-inflammatory effect.
abstract: The first total synthesis of structurally unique flavonoids 1a and 1b is described. These compounds showed very strong anti-inflammatory effect against delayed hypersensitivity in a mouse model.
authors.affiliation: Daiichi Suntory Biomedical Research Co, Ltd, 1-1-1, Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8513, Japan. takashi_nakatsuka@dsup.co.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakatsuka
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tomimori
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Haruo
authors.initials: H
authors.lastname: Nukaya
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005419:Flavonoids / Q000138:chemical synthesis* / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids