title: Parotid gland cancer: a case report of a primitive adenocarcinoma arising from a multirecurrent pleomorphic adenoma.
abstract: Parotid tumours represent a wide group of tumours which are mostly localized in the major salivary glands. We report a case of a 69-year old female with a parotid tumour history who was referred to us with a prominent lump and swelling localized in the right parotid area. In the period between 1985-2002, she was operated 5 times elsewhere for a recurrent pleomorphic adenoma of the right parotid (mixed tumour until 1991), which was histologically confirmed. Sixteen years after the primitive tumour, she underwent mastectomy and axillary dissection for a ductal carcinoma. Routine follow-up has been conducted on both malignancies. Pleomorphic adenoma is the most frequent tumour of the parotid. The potential risk of a malignant transformation can increase over the years with an incidence of 1% to 7%. Management of these recurrences is complex and controversial because of the different treatment options advocated such as radical resection with possible facial nerve sacrifice, or postoperative radiotherapy in non radical cases.
authors.affiliation: Dept. of Surgery "Pietro Valdoni", Università "La Sapienza", Rome, Italy. lucianoizzo@uniroma1.it
authors.forename: L
authors.initials: L
authors.lastname: Izzo
authors.forename: R
authors.initials: R
authors.lastname: Frati
authors.forename: F
authors.initials: F
authors.lastname: Cianfrone
authors.forename: P G
authors.initials: PG
authors.lastname: Sassayannis
authors.forename: U
authors.initials: U
authors.lastname: Costi
authors.forename: G
authors.initials: G
authors.lastname: Galati
authors.forename: L
authors.initials: L
authors.lastname: Lo Mele
authors.forename: Z
authors.initials: Z
authors.lastname: Kharrub
authors.forename: M
authors.initials: M
authors.lastname: Marini
authors.forename: M
authors.initials: M
authors.lastname: Caputo
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D008949:Adenoma, Pleomorphic / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005260:Female; D006801:Humans; D010306:Parotid Gland / Q000473:pathology; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery; D014057:Tomography, X-Ray Computed