Interaction between cyclooxygenase-2 gene polymorphism and dietary n-6 polyunsaturated fatty acids on colon cancer risk: the Singapore Chinese Health Study.
This case-control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the cyclooxygenase (COX)-2 -765G>C gene polymorphism and colon cancer risk among high consumers of dietary n-6 polyunsaturated fatty acids (odds ratio=2.38, 95% confidence interval=1.23-4.59).
Koh
W-P
WP
Department of Community, Occupational and Family Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore. cofkwp@nus.edu.sg
Yuan
J-M
JM
van den Berg
D
D
Lee
H-P
HP
Yu
M C
MC
D000368:Aged; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000209:etiology*; D051546:Cyclooxygenase 2; D004042:Dietary Fats, Unsaturated / Q000009:adverse effects*; D043371:Fatty Acids, Omega-6 / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012307:Risk Factors; D012846:Singapore
D004042:Dietary Fats, Unsaturated; D043371:Fatty Acids, Omega-6; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases