title: Cutaneous ulcers: An unusual manifestation of inherited thrombophilia.
abstract: We report two cases with cutaneous lesions found to be associated with factor V Leiden mutation and low S protein levels. At the time of presentation, no other symptoms were reported. Histopathology of both lesions revealed the presence of widespread intravascular thrombi. The therapeutic response to oral anticoagulants in the first case was dramatic, leading to complete healing of the lesions. Inherited causes of thrombophilia manifested as cutaneous lesions, although rare, should be considered in the differential diagnosis of occlusive vasculopathy.
authors.affiliation: Department of Pathophysiology, School of Medicine, National University of Athens, Greece.
authors.forename: Clio P
authors.initials: CP
authors.lastname: Mavragani
authors.forename: Dimitris
authors.initials: D
authors.lastname: Pikazis
authors.forename: Kyriaki
authors.initials: K
authors.lastname: Aroni
authors.forename: Spiros
authors.initials: S
authors.lastname: Paikos
authors.forename: Michalis
authors.initials: M
authors.lastname: Voulgarelis
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012883:Skin Ulcer / Q000209:etiology*; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants