title: Intraoperative radiotherapy during breast conserving surgery in patients previously treated with radiotherapy for Hodgkin's disease.
abstract: OBJECTIVE
  Women who have received radiotherapy for Hodgkin's disease have an increased risk of developing breast cancer. Breast-conserving surgery followed by breast irradiation is generally considered to be contraindicated in such patients owing to the high cumulative radiation dose to the breast. Mastectomy is therefore recommended as the preferred treatment option in these women.
  
  
  METHODS
  We report 3 patients affected by breast cancer who had previously been treated with mantle radiation for Hodgkin's disease and on whom breast-conserving surgery and full-dose intraoperative radiotherapy with electrons (ELIOT) were performed.
  
  
  RESULTS
  A total dose of 17 Gy (prescribed at 100% isodose) in one case and 21 Gy (at the 90% isodose) in two cases was delivered directly to the mammary gland without acute complications and with good cosmetic results.
  
  
  CONCLUSIONS
  In women previously irradiated for Hodgkin's disease, ELIOT could avoid repeat irradiation of the whole breast, thereby permitting conservative surgical treatment.
authors.affiliation: Department of Breast Surgery, University of Milan, Italy. mattia.intra@ieo.it
authors.forename: Mattia
authors.initials: M
authors.lastname: Intra
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Leonardi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gatti
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Vento
authors.forename: Mario
authors.initials: M
authors.lastname: Ciocca
authors.forename: Paolo
authors.initials: P
authors.lastname: Veronesi
authors.forename: Guillermo
authors.initials: G
authors.lastname: Bassani
authors.forename: Gabriela Rosali
authors.initials: GR
authors.lastname: Dos Santos
authors.forename: Julia
authors.initials: J
authors.lastname: Rodriguez
authors.forename: Alberto
authors.initials: A
authors.lastname: Luini
authors.forename: Roberto
authors.initials: R
authors.lastname: Orecchia
authors.forename: Umberto
authors.initials: U
authors.lastname: Veronesi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000532:radiotherapy / Q000601:surgery; D000075202:Contraindications; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D007432:Intraoperative Period; D007558:Italy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000379:methods*; D013997:Time Factors