Determination of amino acid pairs sensitive to variants in human copper-transporting ATPase 2.
In this study, we use our probabilistic approach to analyze the amino acid pairs in human copper-transporting ATPase 2 (ATP7B) in order to determine which amino acid pairs are more sensitive to 125 variants from missense mutant human ATP7B. The results show 97.6% of 125 variants occur at randomly unpredictable amino acid pairs, which account for 80.9% of amino acid pairs in ATP7B, and the chance of occurring of variant is about 9 times higher in randomly unpredictable amino acid pairs than in predictable pairs. Thus, the randomly unpredictable amino acid pairs are more sensitive to variants in human ATP7B.
Wu
Guang
G
DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province CN-518054, China. hongguanglishibahao@yahoo.com
Yan
Shaomin
S
D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000235:genetics*; D000596:Amino Acids; D027682:Cation Transport Proteins / Q000737:chemistry* / Q000235:genetics*; D019295:Computational Biology; D000073840:Copper-Transporting ATPases; D014644:Genetic Variation; D006801:Humans; D015233:Models, Statistical; D009154:Mutation; D020125:Mutation, Missense
D000596:Amino Acids; D027682:Cation Transport Proteins; D000251:Adenosine Triphosphatases; C000612464:ATP7B protein, human; D000073840:Copper-Transporting ATPases