Granulocytic sarcoma presenting with malignant anasarca in a patient with secondary acute myeloid leukemia.
Granulocytic sarcomas (GS) are rare extramedullary tumor masses composed of immature cells derived from the hematopoietic myeloid series. GS occur in 3% to 7% of cases of acute myeloid leukemia (AML) and can present before, during, or even after the diagnosis of AML. GS can involve different organs, individually or simultaneously, including the skin, lymph nodes, bone, breast, central nervous system, and lung among others. GS involving peritoneal and pleural fluids is a rare presentation. We present an unusual case of a patient with myelodysplastic syndrome whose disease progressed into a secondary AML and developed GS in the ascitic and pleural effusions as the predominant manifestation of disease progression.
Khan
Mohammad Y
MY
Section of Hematology-Oncology, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Blvd WP 2080, Oklahoma City, OK 73104, USA.
Hussein
Khader K
KK
Walter
Max G
MG
Hasan
Muhammad K
MK
Kern
William
W
Kharfan-Dabaja
Mohamed A
MA
D000368:Aged; D001201:Ascites / Q000209:etiology / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000473:pathology*; D017254:Leukemic Infiltration / Q000473:pathology; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D016066:Pleural Effusion, Malignant / Q000209:etiology / Q000473:pathology*; D023981:Sarcoma, Myeloid / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology