title: Update in atherothrombotic disease.
abstract: Crucial advances in our understanding of the pathogenesis of atherothrombosis, defined as atherosclerosis and its thrombotic complications, have been achieved during the past two decades. The historical hypothesis of pathogenesis ("lipid accumulation") has evolved to integrate several factors contributing to the initiation and evolution of this complex disease. Endothelial dysfunction is considered to be the earliest event in atherogenesis. Inflammation and apoptosis play critical roles in its progression and onset. Tissue factor is postulated to be a central actor in determining plaque thrombogenicity. A hyperreactive state of the blood ("vulnerable blood") may be responsible for one-third of all the acute coronary syndromes. This review will discuss emerging concepts in the pathogenesis of and therapeutic approaches to atherothrombotic disease.
authors.affiliation: Cardiovascular Biology Research Laboratory, Zena and Michael A. Wiener Cardiovascular Institute, Box 1030, Mount Sinai School of Medicine, One East 100th Street, New York, NY 10029, USA.
authors.forename: Juan F
authors.initials: JF
authors.lastname: Viles-Gonzalez
authors.forename: Sunil X
authors.initials: SX
authors.lastname: Anand
authors.forename: Carolina
authors.initials: C
authors.lastname: Valdiviezo
authors.forename: M Urooj
authors.initials: MU
authors.lastname: Zafar
authors.forename: Randolf
authors.initials: R
authors.lastname: Hutter
authors.forename: Javier
authors.initials: J
authors.lastname: Sanz
authors.forename: Teresa
authors.initials: T
authors.lastname: Rius
authors.forename: Michael
authors.initials: M
authors.lastname: Poon
authors.forename: Valentin
authors.initials: V
authors.lastname: Fuster
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Badimon
mesh_terms: D000208:Acute Disease; D017209:Apoptosis / Q000502:physiology; D001161:Arteriosclerosis / Q000503:physiopathology*; D004727:Endothelium / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D012307:Risk Factors; D013925:Thromboplastin; D013927:Thrombosis / Q000503:physiopathology*
chemical_list: D013925:Thromboplastin