title: Therapy-resistant epilepsy in children: with the view of the long-term outcome.
abstract: Of 362 children with therapy-resistant epilepsy, 119 patients had generalized tonic seizures, which were the most common seizure type in patients with generalized epilepsy. The long-term observation of the patients with tonic seizures revealed that their seizures were completely controlled in 27 patients for more than 5 years. The effective antiepileptic drugs were VPA (10 patients), PHT (5), CLB (4), ZNS (2), VPA + PHT (4), ZNS + CLB (1) and VPA + AZA (1). For obtaining improvement of tonic seizures, another strong factor is reducing the number of antiepileptic drugs, such as the average number of drugs, which was 4.7 to 2.4 in these 27 patients.
authors.affiliation: National Epilepsy Center, Shizuoka Medical Institute of Neurological Disorders, Japan.
authors.forename: Tateki
authors.initials: T
authors.lastname: Morikawa
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D004351:Drug Resistance; D004827:Epilepsy / Q000145:classification / Q000188:drug therapy* / Q000628:therapy*; D004829:Epilepsy, Generalized / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D012640:Seizures / Q000145:classification; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants