title: Meat intake and the recurrence of colorectal adenomas.
abstract: A large multicenter randomized controlled trial was re-assessed to check whether meat intake and a reduction in its consumption are associated with recurrence of adenomatous polyps of the large bowel, which are precursors of most colorectal malignancies. All subjects (n = 1905; 958 interventions and 947 controls) had one or more histologically confirmed colorectal adenomas removed during a colonoscopy within 6 months before randomization. The subjects were followed-up for approximately 4 years after randomization and a colonoscopy for detecting adenomas was conducted at the 1st and 4th year after randomization. Dietary variables were assessed at baseline (T0) and in conjunction with annual visits at the end of the 1st (T1), 2nd (T2), 3rd (T3) and 4th (T4) years. Odds ratios using logistic regression models for meat variables were estimated based on the average intake at T0, T1, T2, T3 and T4 (prior to the T4 colonoscopy) as well as change (T0-T4) in intake. In the intervention group, the total reduction in median intake of red meat from T0 to T4 was observed by the end of 1st year itself (30 and 31% for men and women, respectively). The analysis provide no evidence to suggest that lower intake or reduction in total and in red meat consumption during a period of 4 years reduces the risk of adenoma recurrence (including multiple or advanced adenoma), whereas the data suggest that high intake of fish is associated with lower risk of adenoma recurrence.
authors.affiliation: Nutritional Epidemiology Branch, Division of Epidemiologya nd Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. amathew@rcctvm.org
authors.forename: A
authors.initials: A
authors.lastname: Mathew
authors.forename: R
authors.initials: R
authors.lastname: Sinha
authors.forename: R
authors.initials: R
authors.lastname: Burt
authors.forename: B
authors.initials: B
authors.lastname: Caan
authors.forename: E
authors.initials: E
authors.lastname: Paskett
authors.forename: F
authors.initials: F
authors.lastname: Iber
authors.forename: W
authors.initials: W
authors.lastname: Kikendall
authors.forename: P
authors.initials: P
authors.lastname: Lance
authors.forename: M
authors.initials: M
authors.lastname: Shike
authors.forename: J
authors.initials: J
authors.lastname: Weissfeld
authors.forename: A
authors.initials: A
authors.lastname: Schatzkin
authors.forename: E
authors.initials: E
authors.lastname: Lanza
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000517:prevention & control*; D004032:Diet; D005260:Female; D005399:Fishes; D006801:Humans; D008297:Male; D008460:Meat; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D016017:Odds Ratio; D012044:Regression Analysis; D017747:Seafood; D012737:Sex Factors