title: [A pilot study of trastuzumab and vinorelbine-combined therapy for metastatic breast cancer].
abstract: We performed combined therapy with trastuzumab-vinorelbine for 6 HER2 positive metastatic breast cancer patients from which informed consent was obtained. As the initial dosage, we administered 4 mg/kg of trastuzumab, followed by a dosage of 2 mg/kg every week thereafter. At the same time, 25 mg/m2 of vinorelbine was administered for 2 weeks, followed by a week of rest. Total administration frequency of trastuzumab was 13-34 times (median: 27 times) and vinorelbine was 8-22 times (median: 17 times). A partial response was seen in 4 patients and no change in 2, for a response rate of 66%. A fixed period effect was recognized in each case, and the TTP was 112-274 days (median: 205 days). The side effects recognized were leukopenia of grade 3 in 1 patient, but she recovered during a withdrawal period. After that, continuous administration was possible. Trastuzumab-vinorelbine combined therapy expanded treatment alternatives for HER2 positive metastatic breast cancer patients and might prolong life.
authors.affiliation: Dept. of Surgical Oncology, Kanazawa University Hospital.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Onishi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tsugawa
authors.forename: Mari
authors.initials: M
authors.lastname: Nakamura
authors.forename: Genichi
authors.initials: G
authors.lastname: Nishimura
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.forename: Takao
authors.initials: T
authors.lastname: Taniya
authors.forename: Masato
authors.initials: M
authors.lastname: Kayahara
authors.forename: Koichi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ohta
authors.forename: Koichi
authors.initials: K
authors.lastname: Miwa
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007258:Informed Consent; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010865:Pilot Projects; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D000068878:Trastuzumab; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab; D014747:Vinblastine; D000077235:Vinorelbine