title: Atypical antipsychotics and risk of cerebrovascular accidents.
abstract: OBJECTIVE
  Randomized controlled trials have suggested that at least one atypical antipsychotic may be associated with an increased risk of stroke in older people with dementia. This study examined the association between atypical antipsychotic use and stroke in the elderly.
  
  
  METHODS
  The authors conducted a retrospective population-based cohort study of patients over the age of 66 by linking administrative health care databases. Three cohorts-users of typical antipsychotics, risperidone, and olanzapine-were identified and compared.
  
  
  RESULTS
  Subjects treated with typical antipsychotics (N=1,015) were compared with those given risperidone (N=6,964) and olanzapine (N=3,421). Model-based estimates adjusted for covariates hypothesized to be associated with stroke risk revealed relative risk estimates of 1.1 (95% CI=0.5-2.3) for olanzapine and 1.4 (95% CI=0.7-2.8) for risperidone.
  
  
  CONCLUSIONS
  Olanzapine and risperidone use were not associated with a statistically significant increased risk of stroke compared with typical antipsychotic use.
authors.affiliation: Institute for Clinical and Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada. n.herrman@utoronto.ca
authors.forename: Nathan
authors.initials: N
authors.lastname: Herrmann
authors.forename: Muhammad
authors.initials: M
authors.lastname: Mamdani
authors.forename: Krista L
authors.initials: KL
authors.lastname: Lanctôt
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D015331:Cohort Studies; D015897:Comorbidity; D003704:Dementia / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D008297:Male; D000077152:Olanzapine; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use; D020521:Stroke / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine