Influence of aging on cortical activity associated with a visuo-motor task.
The aim of this study was to determine how cerebral aging influences the pattern of cortical oscillatory activity when a targeting movement with visual control is planned. Changes in cortical oscillatory activity were assessed by recording the event-related (de)synchronization (ERD/S) of micro and beta rhythms. Young and elderly subjects performed a distal movement, a proximal movement and a visuo-guided targeting movement. Our results demonstrated an increase in micro ERD over ipsilateral regions and showed the spatial extent of micro ERD over parietocentral and parietal regions during motor planning in elderly subjects compared to young ones. After the movement, the beta ERS was significantly modified (a decrease in slope and amplitude) in elderly subjects. The most pronounced age-related changes in ERD/S pattern were observed for the targeting movement. Our results suggest that motor planning is less efficient in elderly subjects. This deficit might result from impaired parietal integrative function and/or changes in inputs from subcortical structures. Subsequently, the changes observed in the post-movement phase might reflect a decrease in (reafferent) sensory inputs and hence impaired their input processing.
Labyt
E
E
Department of Clinical Neurophysiology, R. Salengro Hospital, Lille University Medical Center, EA 2683, Lille Cedex F-59037, France.
Szurhaj
W
W
Bourriez
J-L
JL
Cassim
F
F
Defebvre
L
L
Destée
A
A
Derambure
P
P
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D003344:Cortical Synchronization / Q000379:methods; D004569:Electroencephalography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors