Prolongation of T(2) relaxation times of hippocampus and amygdala in Alzheimer's disease.
There exists controversy on the MR T(2) relaxometry of hippocampus in Alzheimer's disease (AD). The aim of our study was to examine whether there was a prolonged T(2) relaxation time (T(2)) in hippocampus and amygdala in AD, and whether in AD, the relaxometry data correlated to cognitive performance. In a 1.5 T MR scanner, T(2) of hippocampus and amygdala was measured from 51 patients with AD, 23 subjects with vascular dementia (VaD) and 31 healthy elderly controls. The cognitive performance was assessed with the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog). The AD patients had longer T(2) in hippocampus and amygdala than VaD subjects and healthy elderly controls. In AD, the right hippocampal T(2) was correlated with ADAS-Cog scores, whereas amygdaloid T(2) was not.
Wang
Huali
H
Peking University Institute of Mental Health, Beijing 100083, China. hualiw@uci.edu
Yuan
Huishu
H
Shu
Liang
L
Xie
Jingxia
J
Zhang
Dai
D
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology; D000679:Amygdala / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D001834:Body Water / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012016:Reference Values; D015203:Reproducibility of Results; D012720:Severity of Illness Index