Selective human enterovirus and rhinovirus inhibitors: An overview of capsid-binding and protease-inhibiting molecules.
The absence of effective vaccines for most viral infections highlights an urgent necessity for the design and development of effective antiviral drugs. Due to the advancement in virology since the late 1980s, several key events in the viral life cycle have been well delineated and a number of molecular targets have been validated, culminating in the emergence of many new antiviral drugs in recent years. Inhibitors against enteroviruses and rhinoviruses, responsible for about half of the human common colds, are currently under active investigation. Agents targeted at either viral protein 1 (VP1), a relatively conserved capsid structure mediating viral adsorption/uncoating process, or 3C protease, which is highly conserved among different serotypes and essential for viral replication, are of great potential to become antipicornavirus drugs.
Shih
Shin-Ru
SR
School of Medical Technology, Chang Gung University, Taoyuan 333, Taiwan, ROC.
Chen
Shu-Jen
SJ
Hakimelahi
Gholam Hossein
GH
Liu
Hsing-Jang
HJ
Tseng
Chen-Tso
CT
Shia
Kak-Shan
KS
D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D002213:Capsid / Q000378:metabolism*; D004770:Enterovirus / Q000187:drug effects*; D011480:Protease Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D011485:Protein Binding; D012229:Rhinovirus / Q000187:drug effects*
D000998:Antiviral Agents; D011480:Protease Inhibitors