Hepatocellular carcinoma in a patient with liver cirrhosis associated with negative serum HCV tests but positive liver tissue HCV RNA.
A 70-year-old woman was admitted to our hospital because of a liver tumor. Laboratory data revealed mild liver dysfunction. Neither serum anti-HCV antibody nor HCV-RNA was detected. Computed tomography revealed a tumor lesion measuring 2 cm in diameter within the liver. Histological examination of the tumor revealed moderately differentiated hepatocellular carcinoma while the non-tumorous liver tissue demonstrated liver cirrhosis. By the RT-PCR method, HCV-RNA was detected from the non-tumorous liver tissue. We herein report a very rare case of hepatocellular carcinoma in a patient with liver cirrhosis associated with negative serum HCV findings, but positive finding for liver tissue HCV RNA.
Esaki
Tomoka
T
Third Department of Medicine, Fukuoka University School of Medicine, Fukuoka.
Suzuki
Norihisa
N
Yokoyama
Keiji
K
Iwata
Kaoru
K
Irie
Makoto
M
Anan
Akira
A
Nakane
Hidetoshi
H
Yoshikane
Makoto
M
Nishizawa
Shinya
S
Ueda
Syuichi
S
Sohda
Tetsuro
T
Watanabe
Hiroshi
H
Sakisaka
Shotaro
S
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000000981:diagnostic imaging / Q000821:virology*; D005260:Female; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000821:virology*; D008103:Liver Cirrhosis / Q000150:complications / Q000821:virology*; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000821:virology*; D012367:RNA, Viral / Q000032:analysis*; D014057:Tomography, X-Ray Computed
D012367:RNA, Viral