[Metabolic disturbance of tryptophan-nicotinamide conversion pathway by putative endocrine disruptors, bisphenol A and styrene monomer].
Bisphenol A, a monomer of polycarbonate plastics, disturbed the conversion pathway of the amino acid tryptophan to the vitamin nicotinamide. The conversion ratio of tryptophan to nicotinamide was reduced to 1/15 by feeding a diet containing 1% bisphenol A. A putative disturbing reaction is kynurenine-->3-hydroxykynurenine, which is catalyzed by kynurenine monohydroxylase. This is an FAD-enzyme and requires NADPH as a coenzyme. Styrene monomer (1% addition to a normal diet) did not affect the food intake or the body weight, but slightly reduced the conversion ratio of tryptophan-nicotinamide.
Fukuwatari
Tsutomu
T
Laboratories of Food Science and Nutrition, Department of Life Style Studies, School of Human Cultures, University of Shiga Prefecture: 2500 Hassaka-cho, Hikone 522-8533, Japan.
Toriochi
Mai
M
Ohta
Mari
M
Sasaki
Ryuzo
R
Shibata
Katsumi
K
D000818:Animals; D001559:Benzhydryl Compounds; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D006867:Hydrolases / Q000378:metabolism; D007737:Kynurenine / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008297:Male; D009536:Niacinamide / Q000096:biosynthesis*; D010636:Phenols / Q000008:administration & dosage / Q000009:adverse effects*; D051381:Rats; D020058:Styrene / Q000008:administration & dosage / Q000009:adverse effects*; D014364:Tryptophan / Q000378:metabolism*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D006867:Hydrolases; D007737:Kynurenine; D009536:Niacinamide; D010636:Phenols; D020058:Styrene; D014364:Tryptophan; C021480:kynureninase; C006780:bisphenol A; D000098826:Bisphenol A Compounds