Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase.
The genes encoding thiamine kinase in Escherichia coli (ycfN) and thiamine pyrophosphokinase in Bacillus subtilis (yloS) have been identified. This study completes the identification of the thiamine salvage enzymes in bacteria.
Melnick
Jonathan
J
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA.
Lis
Ewa
E
Park
Joo-Heon
JH
Kinsland
Cynthia
C
Mori
Hirotada
H
Baba
Tomoya
T
Perkins
John
J
Schyns
Ghislain
G
Vassieva
Olga
O
Osterman
Andrei
A
Begley
Tadhg P
TP
D001412:Bacillus subtilis / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D005798:Genes, Bacterial / Q000502:physiology*; D009243:NAD / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D013836:Thiamin Pyrophosphokinase / Q000235:genetics*; D013831:Thiamine / Q000378:metabolism*
D009243:NAD; D017853:Phosphotransferases (Alcohol Group Acceptor); C035182:thiamin kinase; D013836:Thiamin Pyrophosphokinase; D013831:Thiamine