title: Osteosarcoma associated with hyperparathyroidism.
abstract: The fourth case in the literature is presented of a patient with the rare association of hyperparathyroidism and osteosarcoma. A 56-year-old woman presented with hyperparathyroidism and a lesion in the tibia. Initial diagnosis was brown tumor. Histology, however, revealed osteosarcoma, and the patient was treated accordingly. The experimental induction of osteosarcoma by parathormone in rodent studies makes this finding alarming, considering the increasing use of parathormone in the treatment of osteoporosis. The mechanism by which osteosarcoma is induced in humans cannot be explained based on current knowledge of mechanisms of action of parathyroid hormone.
authors.affiliation: Istituti Orthopedici Rizzoli, Via Pupilli 1, 40136, Bologna, Italy.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Jutte
authors.forename: Renato
authors.initials: R
authors.lastname: Rosso
authors.forename: Massimiliano
authors.initials: M
authors.lastname: de Paolis
authors.forename: Costatino
authors.initials: C
authors.lastname: Errani
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pasini
authors.forename: Laura
authors.initials: L
authors.lastname: Campanacci
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bacci
authors.forename: Franco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Mario
authors.initials: M
authors.lastname: Mercuri
mesh_terms: D001859:Bone Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005360:Fibula / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012516:Osteosarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography