Enhanced production of farnesol by Candida albicans treated with four azoles.
The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.
Hornby
Jacob M
JM
School of Biological Sciences, University of Nebraska, Lincoln 68588-0666,USA. jmhornby@lcsc.edu
Nickerson
Kenneth W
KW
D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism*; D002177:Candidiasis / Q000382:microbiology; D005204:Farnesol / Q000032:analysis / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D013261:Sterols / Q000096:biosynthesis
D000935:Antifungal Agents; D001393:Azoles; D019086:Bridged Bicyclo Compounds, Heterocyclic; D013261:Sterols; C079089:zaragozic acid B; D005204:Farnesol