Nuclear factor-kappaB p65 is a prognostic indicator in gastric carcinoma.
BACKGROUND
In common with other investigators, we have reported the constitutive activation of transcription factor nuclear factor-kappaB (NF-kappaB) in a variety of carcinomas, but there is no definite information on its clinical significance.


METHODS
NF-kappaB p65 activation was determined by immunohistochemical analysis of surgically resected specimens from 63 gastric carcinomas. The 63 patients were divided into a high NF-kappaB group (21 patients) and a low NF-kappaB group (42 patients). Forty-seven of the 63 patients underwent curative resection. The 47 patients consisted of 13 high NF-kappaB patients and 34 low NF-kappaB patients.


RESULTS
The high NF-kappaB group demonstrated a shorter overall survival rate compared with the low NF-kappaB group (p=0.015). In the 47 patients who underwent curative resection, the high NF-kappaB group also showed a poor survival prognosis (p=0.032). Multivariate analysis indicated that NF-kappaB activation is a potential prognostic factor in gastric carcinoma.


CONCLUSIONS
Constitutive activation of NF-kappaB p65 may be a new prognostic parameter in gastric carcinoma.
Yamanaka
Naoki
N
Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sasaki
Nobuhiko
N
Tasaki
Akira
A
Nakashima
Hiroshi
H
Kubo
Makoto
M
Morisaki
Takashi
T
Noshiro
Hirokazu
H
Yao
Takashi
T
Tsuneyoshi
Masazumi
M
Tanaka
Masao
M
Katano
Mitsuo
M
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D051996:Transcription Factor RelA
D014408:Biomarkers, Tumor; D016328:NF-kappa B; D051996:Transcription Factor RelA