New imidazole alkaloids from the Indonesian sponge Leucetta chagosensis.
Chemical investigation of the sponge Leucetta chagosensis collected in Indonesia afforded five new imidazole alkaloids, naamine F (2), naamine G (3), kealiinine A (6), kealiinine B (7), and kealiinine C (8), in addition to the known compound naamine A (1). Naamine G (3) exhibited strong antifungal activity against the phytopathogenic fungus Cladosporium herbarum and also showed mild cytotoxicity against mouse lymphoma (L5178Y) and human cervix carcinoma (HeLa) cell lines. In the brine shrimp assay, kealiinine A (6) was more active than naamine G (3). The structures of the new compounds were unambiguously established by 1D and 2D NMR and MS data.
Hassan
Wafaa
W
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb. 26.23, D-40225 Düsseldorf, Germany.
Edrada
RuAngelie
R
Ebel
Rainer
R
Wray
Victor
V
Berg
Albrecht
A
van Soest
Rob
R
Wiryowidagdo
Sumali
S
Proksch
Peter
P
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D002963:Cladosporium / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D013058:Mass Spectrometry; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D007093:Imidazoles