Lack of effect of recombinant human growth hormone on the in vitro activities of antiretroviral drugs against human immunodeficiency virus type 1.
We studied the effects of recombinant human growth hormone (r-hGH) on human immunodeficiency virus type 1 replication by growing both wild-type and drug-resistant variants of virus in the presence of various concentrations of eight different antiretroviral drugs. r-hGH had no significant effect on either viral replication or the 50% inhibitory concentrations of these compounds.
Wainberg
Mark A
MA
McGill AIDS Center, Jewish General Hospital, Lady Davis Institute, 3755 Cote St. Catherine Rd., Montreal, Quebec H3T 1E2, Canada. mark.wainberg@mcgill.ca
Brenner
Bluma G
BG
Daar
Eric
E
Gertner
Joseph M
JM
Olivier
Clement
C
Kenley
Susan
S
D019380:Anti-HIV Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D024882:Drug Resistance, Viral; D013006:Growth Hormone / Q000494:pharmacology*; D016655:HIV Core Protein p24 / Q000032:analysis / Q000096:biosynthesis; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D016655:HIV Core Protein p24; D013006:Growth Hormone