[Association between Alzheimer's disease and nitric oxide synthase III polymorphism].
OBJECTIVE
To explore the association between Alzheimer's disease (AD) and nitric oxide synthase (NOS) III in Chinese Han population.


METHODS
Seventy-five AD and 68 normal controls were genotyped for NOS III G894T polymorphism. Genotyping was carried out by PCR-RFLP methods.


RESULTS
There were two genotypes of NOS III, GG and GT, in either AD patients or normal controls. The frequencies of these two genotypes were 78.7% and 21.3% in AD patients and 82.4% and 17.6% in normal controls, respectively. No association was found between AD and NOS III genotype (P > 0.05). There were two alleles, G and T, in AD patients and normal controls. The frequencies of these two alleles were 89.3% and 10.7% in AD patients and 91.2% and 8.8% in normal controls, respectively, indicating that there was no association between AD and NOS III allels (P > 0.05).


CONCLUSIONS
There was no association between AD and NOS III G894T polymorphism in Chinese Han population.
Wang
Qing-hua
QH
Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. wqhaaa@hotmail.com
Zhang
Jun-wu
JW
Zhang
Zhen-xin
ZX
Wu
Cheng-bin
CB
Chen
Deng
D
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length
D019001:Nitric Oxide Synthase