Anaplasma phagocytophilum infection induces protracted neutrophil degranulation.
Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for > or =18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.
Choi
Kyoung-seong
KS
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Grab
Dennis J
DJ
Dumler
J Stephen
JS
D041081:Anaplasma phagocytophilum / Q000472:pathogenicity*; D015703:Antigens, CD / Q000378:metabolism; D000943:Antigens, Differentiation / Q000378:metabolism; D039481:CD11b Antigen / Q000378:metabolism; D015815:Cell Adhesion Molecules; D015550:Cell Degranulation; D016873:Ehrlichiosis / Q000382:microbiology; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D009504:Neutrophils / Q000382:microbiology / Q000502:physiology*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D039481:CD11b Antigen; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D020780:Matrix Metalloproteinase 9