[Special morphological changes of pathologic cells in two cases of Waldenström's macroglobulinemia].
Waldenström's macroglobulinemia (WM) is one of malignant hematological disease on account of abnormal proliferation of B lymphocyte clone and the pathologic cells of WM possess ability to secrete monoclonal immunoglobulin M. In this study, the diagnosis and morphological characteristics of 2 patients with WM were analyzed. The results showed that a special kind of "foam cells" were found by cytochemical staining examinations in both cases, which displayed characteristics of lymphocytes, but neither monocyte-macrophage nor fatty cells. The periodic acid-Shiff's reaction (PAS) demonstrated strong positive, especially on the inclusion bodies in pathologic cell plasma while the acid phosphatase, and alpha-butanoic acetate esterase stainings, resulted both in negative. In conclusion, the cells found in the two cases reported may be described as gemmy ring-like lymphocyte in morphology, a special subtype of ring-like lymphocyte.
Chen
Xue-Liang
XL
Department of Hematology, Tumor Center of Qilu Hospital, Shandong University, Jinan 250012, China. xlchen1999@yahoo.com
Li
Fang-Lin
FL
Zhao
Chuan-Li
CL
Jiang
Dao-Zi
DZ
Qin
Ping
P
Wang
Ying-Fu
YF
Yan
Shu-Xin
SX
D000328:Adult; D006801:Humans; D008297:Male; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*