Multiple groups of endogenous betaretroviruses in mice, rats, and other mammals.
Betaretroviruses exist in endogenous and exogenous forms in hosts that are widely distributed and evolutionarily distantly related. Here we report the discovery and characterization of several previously unknown betaretrovirus groups in the genomes of Mus musculus and Rattus norvegicus. Each group contains both mouse and rat elements, and several of the groups are more closely related to previously known betaretroviruses from nonmurine hosts. Some of the groups also include members from hosts which were not previously known to harbor betaretroviruses, such as the gray mouse lemur (Microcebus murinus) and Seba's short-tailed bat (Carollia perspicillata). Some of the mouse and rat elements possess intact open reading frames for gag, pro, pol, and/or env genes and display characteristics of having retrotransposed recently. We propose a model whereby betaretroviruses have been evolving within the genomes of murid rodents for at least the last 20 million years and, subsequent to (or concomitant with) the global spread of their murid hosts, have occasionally been transmitted to other species.
Baillie
Gregory J
GJ
Terry Fox Laboratory, B.C. Cancer Agency, 601 W. 10th Ave, Vancouver, B.C. V5Z 1L3, Canada.
van de Lagemaat
Louie N
LN
Baust
Corinna
C
Mager
Dixie L
DL
D000595:Amino Acid Sequence; D000818:Animals; D020077:Endogenous Retroviruses / Q000145:classification / Q000235:genetics*; D015752:Genes, env; D051379:Mice / Q000821:virology*; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D051381:Rats / Q000821:virology*; D020079:Terminal Repeat Sequences