[Preparation of chitosan-collagen sponge and its application in wound dressing].
We have prepared a wound dressing made from chitosan and collagen. Its clinical curative effect was detected. Chitosan solution was put into purified collagen solution. Then, the solution became sponge by means of freeze drying, and it was subjected to a series of toxicology tests, including acute toxicity, stimulation test, allergic and hemolysis tests, as well as the clinical test of openning trauma in orthopedics. All of the results of toxicology tests were negative. The chitosan-collagen sponge could not only accelerate the speed of curing but also restrain the extravasate. Therefore, the chitosan-collagen sponge has good biocompatibility and clinical curative effect. It is a prospective security-biomaterial for medical use.
Ye
Chunting
C
Affiliated Guangzhou Red Cross Hospital, Medical College of Jinan University, Guangzhou 510220, China.
Zou
Haiyan
H
Peng
Yanhao
Y
Liu
Xiangrong
X
Chen
Zhiguang
Z
D001672:Biocompatible Materials / Q000008:administration & dosage*; D001684:Biological Dressings; D002686:Chitin / Q000031:analogs & derivatives* / Q000302:isolation & purification* / Q000627:therapeutic use; D048271:Chitosan; D003094:Collagen / Q000302:isolation & purification* / Q000627:therapeutic use; D006801:Humans; D008567:Membranes, Artificial; D014945:Wound Healing / Q000187:drug effects*
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D002686:Chitin; D003094:Collagen; D048271:Chitosan