title: CuI catalyzed N-arylation of amide as a key step for the preparation of 3-aryl beta-carbolin-1-ones.
abstract: An expedient synthetic route for 3-aryl beta-carbolin-1-ones was developed starting from ethyl acetamidocyanoacetate and chalcone derivatives. The five- and six-membered nitrogen-containing rings in the beta-carbolin-1-ones were elaborated efficiently by an intramolecular ketone-nitrile annulation and an intramolecular N-arylation of amide respectively.
authors.affiliation: Department of Chemistry, Nanjing University, Nanjing 210093, PR China.
authors.forename: Shaozhong
authors.initials: S
authors.lastname: Wang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Sun
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Hu
authors.forename: Jun O
authors.initials: JO
authors.lastname: Liu
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu