Dendritic cell, the immunotherapeutic cell for cancer.
Dendritic cells play an important role in the development of effective cancer vaccines. These cells have the potential to present tumour-specific antigens and thereby induce an immune response. Various studies involving clinical trials have investigated the efficacy of administering antigen-loaded dendritic cells for cancer therapy. In order to design such experiments it is important to consider specific antigens, which initiate either a CD4+ or CD8+ response or both. The present review discusses the unique properties of dendritic cells as an immunotherapeutic cell for cancer.
Nagaraj
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Department of Internal Medicine I, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
Ziske
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Schmidt-Wolf
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IG
D000951:Antigens, Neoplasm / Q000737:chemistry; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002986:Clinical Trials as Topic; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D010455:Peptides / Q000737:chemistry; D014162:Transfection; D014612:Vaccines / Q000737:chemistry
D000951:Antigens, Neoplasm; D010455:Peptides; D014612:Vaccines