Trans-selective conversions of gamma-hydroxy-alpha,beta-alkynoic esters to gamma-hydroxy-alpha,beta-alkenoic esters.
Gamma-hydroxy-alpha,beta-acetylenic esters are used as precursors to prepare gamma-hydroxy-alpha,beta-alkenoic esters by means of trans-selective additions of two hydrogen atoms or one hydrogen atom and one iodine atom across the triple bonds. These methods allow for the preparation of beta-substituted and alpha,beta-disubstituted alkenoic esters in highly stereoselective manners. [reaction--see text]
Meta
Christopher T
CT
Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA.
Koide
Kazunori
K