title: Cathepsin K inhibitor-polymer conjugates: potential drugs for the treatment of osteoporosis and rheumatoid arthritis.
abstract: The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD, University of Utah, 30 S 2000 E Rm. 301, Salt Lake City, UT 84112, USA.
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Pechar
authors.forename: P
authors.initials: P
authors.lastname: Kopecková
authors.forename: D
authors.initials: D
authors.lastname: Brömme
authors.forename: J
authors.initials: J
authors.lastname: Kopecek
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D056657:Cathepsin K; D002403:Cathepsins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use*; D006801:Humans; D010024:Osteoporosis / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D015853:Cysteine Proteinase Inhibitors; D011108:Polymers; D002403:Cathepsins; C534130:CTSK protein, human; D056657:Cathepsin K