[Retrospective diagnosis of radiation inhalation lesions of the bronchial mucosa in clean-up personnel after the nuclear accident at the Chernobyl nuclear reactor using the micronucleus test].
The aim of the study was to detect radiation lesions in histological samples of bronchial mucosa in Chernobyl wreckers suffering from chronic non-obstructive bronchitis 10 years after Chernobyl accident by the micronuclear test. The study group consisting of Chernobyl wreckers was comparable to the controls by sex, age, smoking and morphological variants of chronic bronchitis. The test in the study group was positive as it showed a significant increase in the number of the ciliated cells in bronchial mucosa as compared to the control group. This suggests a long-term persistence of the radionuclides in the wreckers' bronchial mucosa. The micronuclear test is recommended for diagnosis of inhalation damage to the lungs in persons exposed to radiation.
Lisochkin
B G
BG
I.P.Pavlov Research Institute of Pulmonology, Sankt-Petersburg Medical University, 197022, St-Petersburg.
Kravtsov
V Iu
VIu
Rybachenko
V V
VV
D000328:Adult; D029481:Bronchitis, Chronic / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D020545:Respiratory Mucosa / Q000473:pathology* / Q000528:radiation effects; D012189:Retrospective Studies; D014455:Ukraine