Balance between acute graft-versus-host disease and graft-versus-tumor effect after reduced-intensity transplantation for metastatic renal cell carcinoma.
We describe a patient who had received reduced-intensity stem cell transplantation (RIST) for metastatic renal cell carcinoma (RCC). A 37-year-old man developed rapid progression of RCC during steroid therapy for immune-mediated thrombocytopenia and graft-versus-host disease (GVHD). After discontinuation of corticosteroid, RCC achieved long stable disease with the presence of chronic GVHD, despite low dose of prednisolone. This case suggests the impact of immunosuppression on progression of metastatic RCC after RIST.
Hori
Akiko
A
Hematopoietic Stem Cell Transplant Unit, National Cancer Center Hospital, Tokyo, Japan.
Kami
Masahiro
M
Kim
Sung-Won
SW
Makimoto
Atsushi
A
Tanosaki
Ryuji
R
Takaue
Yoichi
Y
D000208:Acute Disease; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000473:pathology*; D020350:Graft vs Tumor Effect / Q000276:immunology*; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008297:Male; D011859:Radiography; D033581:Stem Cell Transplantation