title: ADRB2 polymorphisms and asthma susceptibility: transmission disequilibrium test and meta-analysis.
abstract: BACKGROUND
  The beta(2)-adrenergic receptor (ADRB2) is the most common adrenergic receptor in the lung, and associations between ADRB2 polymorphisms and intermediate phenotypes of asthma have been reported. Four missense polymorphisms (Arg16Gly, Gln27Glu, Val34Met, and Thr164Ile) and one polymorphism in the 5' leader cistron of the ADRB2 messenger RNA has been identified. In vitro studies have shown that these missense polymorphisms can affect ADRB2 function.
  
  
  METHODS
  To examine possible associations of ADRB2 polymorphisms with asthma susceptibility, we performed transmission disequilibrium tests (TDT) of 137 Japanese families identified through children with atopic asthma.
  
  
  RESULTS
  We did not find associations between any alleles of the ADRB2 polymorphisms and asthma by TDT (p > 0.1). We also performed a meta-analysis of data from all available studies. The random-effects model showed no significant odds ratio for the Arg16Gln (odds ratio = 1.05, p = 0.53) or Gln27Glu (odds ratio = 1.12, p = 0.22) polymorphism.
  
  
  CONCLUSIONS
  Our data indicate that ADRB2 does not contribute substantially to susceptibility to asthma, but it is possible that these polymorphisms influence disease activity and drug responses in individuals with asthma.
authors.affiliation: Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki 305-8575, Japan.
authors.forename: Ohsuke
authors.initials: O
authors.lastname: Migita
authors.forename: Emiko
authors.initials: E
authors.lastname: Noguchi
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jian
authors.forename: Masanao
authors.initials: M
authors.lastname: Shibasaki
authors.forename: Takuo
authors.initials: T
authors.lastname: Migita
authors.forename: Kunio
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Matsui
authors.forename: Tadao
authors.initials: T
authors.lastname: Arinami
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D018343:Receptors, Adrenergic, beta-2