Synthesis and characterization of poly(dimer acid-brassylic acid) copolymer and poly(dimer acid-pentadecandioic acid) copolymer.
Poly(dimer acid-brassylic acid) [P(DA-BA)] copolymers and poly(dimer acid-pentadecandioic acid) [P(DA-PA)] copolymers were prepared by melt polycondensation of the corresponding mixed anhydride prepolymers. The copolymers were characterized by Fourier transform infrared (FTIR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), wide angle x-ray powder-diffraction, and thermal gravimetric analysis (TGA). In vitro studies show that all the copolymers are degradable in phosphate buffer at 37 degrees C, and leaving an oily dimer acid residue after hydrolysis for the copolymer with high content of dimer acid. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follow first-order release kinetics. All the preliminary results suggested that the copolymer might be potentially used as drug delivery devices.
Guo
Wen-xun
WX
Department of Chemistry, Huazhong University of Science and Technology, Wuhan, Hubei 430074, Peoples Republic of China.
Huang
Kai-xun
KX
D000473:Alkanes / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000493:pharmacokinetics; D002939:Ciprofloxacin / Q000493:pharmacokinetics; D003998:Dicarboxylic Acids / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D000473:Alkanes; D000890:Anti-Infective Agents; D003998:Dicarboxylic Acids; D005227:Fatty Acids; D011108:Polymers; C094073:tridecanedioic acid; D002939:Ciprofloxacin; C117025:pentadecanoic acid