The role of sulfatide in thrombogenesis and haemostasis.
In 1961, Wago et al. reported a potential anticoagulant role for sulfatide using animal experiments. Since then there have been many studies of sulfatide in the field of thrombogenesis/haemostasis, yielding contradictory conclusions. Some report that sulfatide has anti-thrombotic activity because it prolongs clotting time, inhibits platelet adhesion, and prolongs bleeding. Others report that sulfatide induces thrombosis in animal models. This mini-review is a chronologic review of reports examining the role of sulfatide in thrombogenesis/haemostasis together with the introduction of data from our laboratory and a discussion of the possible mechanisms underlying these curious phenomena.
Kyogashima
Mamoru
M
Seikagaku Corporation, Central Research Laboratories, 1253 Tateno 3 chome, Higashiyamato-shi, Tokyo 207-0021, Japan. mkyogashi@aichi-cc.jp
D000818:Animals; D000925:Anticoagulants / Q000378:metabolism / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects*; D004195:Disease Models, Animal; D006487:Hemostasis; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects*; D013433:Sulfoglycosphingolipids / Q000378:metabolism* / Q000494:pharmacology*; D013927:Thrombosis / Q000378:metabolism*; D020246:Venous Thrombosis / Q000378:metabolism
D000925:Anticoagulants; D013433:Sulfoglycosphingolipids