title: A new lead compound for abscisic acid biosynthesis inhibitors targeting 9-cis-epoxycarotenoid dioxygenase.
abstract: 9-cis-Epoxycarotenoid dioxygenase (NCED), a key enzyme in abscisic acid (ABA) biosynthesis, cleaves the olefinic double bond of 9-cis-epoxycarotenoid. Several analogues of nordihydroguaiaretic acid (NDGA) were designed and synthesized, and their efficacy as inhibitors of NCED was examined. One of the synthesized compounds (20) was found to be an inhibitor of this enzyme, and inhibited ABA accumulation and stomatal closing, suggesting that 20 should be ABA biosynthesis inhibitor.
authors.affiliation: RIKEN Tsukuba Institute, Koyadai 3-1-1, Ibaraki, Tsukuba 305-0074, Japan.
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Han
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kitahata
authors.forename: Tamio
authors.initials: T
authors.lastname: Saito
authors.forename: Masatomo
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shinozaki
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yoshida
authors.forename: Tadao
authors.initials: T
authors.lastname: Asami
mesh_terms: D000040:Abscisic Acid / Q000096:biosynthesis*; D049308:Dioxygenases; D016503:Drug Delivery Systems / Q000379:methods*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D010105:Oxygenases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018515:Plant Leaves / Q000201:enzymology; D010940:Plant Proteins; D018724:Spinacia oleracea / Q000187:drug effects / Q000201:enzymology
chemical_list: D004791:Enzyme Inhibitors; D010940:Plant Proteins; D000040:Abscisic Acid; D010105:Oxygenases; D049308:Dioxygenases; C109043:9-cis-epoxy-carotenoid dioxygenase