title: Paraganglioma of the posterior mediastinum diagnosed by immunohistochemical staining.
abstract: Paraganglioma of the mediastinum are rare neoplasms. To date, no definitive morphologic criteria exist that correlate with the clinical outcome of these tumors. We have encountered a case of paraganglioma in which biological behavior was assessed by immunohistochemical staining to determine whether supplementary postoperative treatment was needed. A 28-year-old man came to our hospital because of an abnormal shadow on a radiogram of the chest. He had no symptoms. Hematological findings were unremarkable. Diagnostic imaging suggested a neurogenic tumor. Surgical resection was performed in September, 2002. A typical nesting pattern (Zellballen) and positivity for chromogranin on immunohistochemical staining were evident, indicating neuroendocrine characteristics, and paraganglioma was diagnosed. Tissue specimens indicated an MIB-1-labeling index of 1.3% on MIB-1 staining, and a relatively well maintained distribution of S-100 protein-positive sustentacular cells, which were suggestive of a benign tumor. The patient did not receive any supplementary therapy postoperatively but was given careful follow-ups.
authors.affiliation: Department of Thoracic Surgery, Nippon Medical School Chiba Hokusoh Hospital, 1715 Kamakari, Inba-mura, Inba-gun, Chiba 270-1694, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yoshino
authors.forename: Takao
authors.initials: T
authors.lastname: Hisayoshi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Hidetsugu
authors.initials: H
authors.lastname: Ogasawara
authors.forename: Shigeo
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Oaki
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002864:Chromogranins / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D010235:Paraganglioma / Q000175:diagnosis* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D013194:Staining and Labeling
chemical_list: D014408:Biomarkers, Tumor; D002864:Chromogranins; D019394:Ki-67 Antigen; D009418:S100 Proteins