title: Quantitative lung perfusion scan as a predictor of aerosol distribution heterogeneity and disease severity in children with cystic fibrosis.
abstract: BACKGROUND
  The assessment of lung ventilation by radionuclide imaging has proved useful for the optimization of aerosol therapy in children with cystic fibrosis. Further analysis of lung perfusion may provide additional information.
  
  
  METHODS
  Quantitative analysis of regional lung aerosol distribution (Tc phytates) and perfusion (Tc macroaggregates) homogeneity was performed in 18 children with cystic fibrosis, using the third and fourth spatial moments (skew and Kurtosis) of count distribution. Patients were chosen from a prospective study whose goal was to compare the efficacy of two nebulization methods of a radiolabelled aerosol: one session involved a nebulizer activated by patient inspiratory flow (control session), whereas the other involved a nebulizer powered by a pressure support device (PS session).
  
  
  RESULTS
  Quantitative regional distribution of perfusion was similar to aerosol distribution, although skew and Kurtosis were lower, indicating better homogeneity. Perfusion skew was inversely correlated with pulmonary volumes and Shwachman score, even more significantly than ventilation skew. Using receiver operating characteristic curve analysis, a perfusion skew threshold of 0.67 was predictive of disease severity (FEV1 > or =60% or FEV1 <60%) with 86% sensitivity and 91% specificity. Furthermore, same skew threshold allowed the identification of patients who were 'PS responders' (greater amount of radioactivity deposited after the PS session) or 'PS non-responders' with 80% sensitivity and 77% specificity.
  
  
  CONCLUSIONS
  Quantification of regional lung perfusion is easy to perform and heterogeneity of the distribution is closely correlated to disease severity. Moreover, perfusion skew can identify patients who are likely to benefit from pressure support (to optimize aerosol therapy) and may be helpful for orienting potential non-responders towards alternative therapies.
authors.affiliation: Department of Nuclear Medicine, H. Mondor Hospital, Assistance Publique - Hôpitaux de Paris, Paris XII University, Créteil, France. eitti@wanadoo.fr
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Itti
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
authors.forename: Jérôme
authors.initials: J
authors.lastname: Pigeot
authors.forename: Daniel
authors.initials: D
authors.lastname: Isabey
authors.forename: Annick
authors.initials: A
authors.lastname: Clement
authors.forename: Eva
authors.initials: E
authors.lastname: Evangelista
authors.forename: Alain
authors.initials: A
authors.lastname: Harf
authors.forename: Michel
authors.initials: M
authors.lastname: Meignan
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000627:therapeutic use; D002648:Child; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D012129:Respiratory Function Tests / Q000379:methods; D012720:Severity of Illness Index; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D000336:Aerosols; D000894:Anti-Inflammatory Agents, Non-Steroidal; D019275:Radiopharmaceuticals