Oleanene constituents of Lantana cujabensis.
A new compound, 3beta,25-epoxy-3alpha-hydroxy-22beta-isobutanoyloxyolean-12-ene-28-oic acid (1), and two known triterpenoids lantanilic acid (2) and camaric acid (3) were isolated from the stem and leaves of Lantana cujabensis. Their structures were elucidated by spectroscopic methods. The ethanol extracts did not show significant in vitro antiplasmodial activity against chloroquine-sensitive or resistant strains of Plasmodium falciparum.
Okunade
Adewole L
AL
Department of Biology, Washington University in St Louis, St Louis, MO 63130, USA. okunade@biology.wustl.edu
Lewis
Walter H
WH
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D032410:Lantana; D016778:Malaria, Falciparum / Q000517:prevention & control; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems; D010963:Plasmodium falciparum / Q000187:drug effects*; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
C487842:3beta,25-epoxy-3alpha-hydroxy-22beta-isobutanoyloxyolean-12-ene-28-oic acid; D000962:Antimalarials; D010936:Plant Extracts; D014315:Triterpenes; D009828:Oleanolic Acid; D002738:Chloroquine