title: Proteoglycan loss in human knee cartilage: quantitation with sodium MR imaging--feasibility study.
abstract: The feasibility of using sodium magnetic resonance (MR) imaging to detect proteoglycan loss in early-stage osteoarthritis is evaluated. Fixed charge density (FCD) maps were calculated from sodium MR imaging data collected in nine healthy volunteers and three individuals with symptoms of early-stage osteoarthritis by using a 4.0-T clinical MR imaging unit. Data from the healthy individuals revealed a mean FCD of -182 mmol/L +/- 9. Data from the symptomatic subjects revealed focal regions of decreased FCD, with mean values ranging from -108 to -144 mmol/L, indicating proteoglycan loss from the cartilage matrix. The data suggest that sodium MR imaging has potential for use as a quantitative diagnostic tool to measure changes in proteoglycan content in early-stage osteoarthritis.
authors.affiliation: Department of Radiology, University of Pennsylvania, B1 Stellar-Chance Laboratories, 422 Curie Boulevard, Philadelphia, PA 19104-6100, USA. wheaton@seas.upenn.edu
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wheaton
authors.forename: Arijitt
authors.initials: A
authors.lastname: Borthakur
authors.forename: Erik M
authors.initials: EM
authors.lastname: Shapiro
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
authors.forename: Sarma V S
authors.initials: SV
authors.lastname: Akella
authors.forename: J Bruce
authors.initials: JB
authors.lastname: Kneeland
authors.forename: Ravinder
authors.initials: R
authors.lastname: Reddy
mesh_terms: D000328:Adult; D002358:Cartilage, Articular / Q000737:chemistry*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000378:metabolism*; D019047:Phantoms, Imaging; D011509:Proteoglycans / Q000032:analysis*; D012964:Sodium / Q000032:analysis*
chemical_list: D011509:Proteoglycans; D012964:Sodium