Drug delivery devices based on mesoporous silicate.
A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its characterization by X-ray, N2 absorption-desorption isotherm, and thermogravimetry analysis have been described. Drug loading was performed by a soaking procedure. Drug-loaded matrices were characterized for entrapped drug amount, water absorption ability, and thermogravimetric behavior. Drug release studies also were performed at pH 1.1 and 6.8 mimicking gastrointestinal fluids. Experimental results showed that this type of matrix is able to trap the bioactive agents by a soaking procedure and, then, to release them in conditions mimicking the biological fluids. Also, the high affinity of these matrices for water makes them potentially biocompatible. Release data suggest that the matrix impregnated with diflunisal offers good potential as a system for the modified drug release.
Cavallaro
Gennara
G
Dipartimento di Chimica e Tecnologie Farmaceutiche, Palermo, Italy. gennacav@unipa.it
Pierro
Paola
P
Palumbo
Fabio Salvatore
FS
Testa
Flaviano
F
Pasqua
Luigi
L
Aiello
Rosario
R
D000327:Adsorption / Q000187:drug effects; D000535:Aluminum / Q000737:chemistry; D000538:Aluminum Silicates / Q000138:chemical synthesis / Q000737:chemistry*; D004061:Diflunisal / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004355:Drug Stability; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics; D008422:Materials Testing; D009288:Naproxen / Q000008:administration & dosage / Q000493:pharmacokinetics; D009584:Nitrogen / Q000737:chemistry; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity / Q000187:drug effects*; D012995:Solubility; D013818:Thermogravimetry / Q000379:methods; D014867:Water; D014965:X-Rays
D000538:Aluminum Silicates; D017646:Organosilicon Compounds; D014867:Water; C049037:aluminosilicate; D009288:Naproxen; D004061:Diflunisal; D000535:Aluminum; D009584:Nitrogen; D007052:Ibuprofen