[Comparison of the antioxidant enzyme levels with the degree of dysfunction in patients with myocardial dysfunction].
OBJECTIVE
Myocardial dysfunction in patients with cardiomyopathy is proposed to occur due to membrane changes caused by oxidative stress. In our study we evaluate whether there is any relation between the degree of myocardial dysfunction and antioxidant enzymes.


METHODS
We studied superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and catalase (CAT) enzyme activities from blood samples of 60 patients (30 patients had ejection fraction (EF) < %35 and 30 patients had EF= %35-50) who have myocardial dysfunction according to clinical findings and two-dimensional echocardiography, and 20 healthy volunteers.


RESULTS
We found erythrocyte SOD enzyme activities of patients with EF < %35 (group 3) were significantly lower than in control subjects (group 1) (p=0.01). However in group 2 patients (EF= %35-50), erythrocyte SOD activities were found to be lower than in control subjects but this difference was not significant. Erythrocyte CAT and GSHPx enzyme activities of group 3 were also significantly lower than in control group (p=0.04 and p=0.02 respectively).


CONCLUSIONS
In conclusion, reactive oxygen species play a significant role in the initiation and the progression of congestive heart failure. Increased free radicals levels may cause myocardial muscle dysfunction.
Sezgin
Nurşen
N
Department of Biochemistry, Medical Faculty, Inönü University, Malatya. nursensezgin@hotmail.com
Sezgin
Alpay Tufan
AT
Karabulut
Aysun
A
Topal
Ergün
E
Barutçu
Irfan
I
Gözükara
Engin M
EM
D000975:Antioxidants / Q000378:metabolism*; D009202:Cardiomyopathies / Q000097:blood* / Q000000981:diagnostic imaging; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004452:Echocardiography; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase