Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C.
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
Storer
R Ian
RI
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Takemoto
Toshiyasu
T
Jackson
Philip S
PS
Brown
Dearg S
DS
Baxendale
Ian R
IR
Ley
Steven V
SV
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry; D034261:Epothilones / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D001685:Biological Factors; D034261:Epothilones; D018942:Macrolides; D011108:Polymers; C426624:epothilone C