[Aspirin versus oral anticoagulants following lower limb arterial reconstructions: what to choose?].
Graft thrombosis in long-term postoperative period after lower extremity arterial reconstructions often results in limb loss. In some studies prolonged antithrombotic therapy was demonstrated to improve long-term patency of vascular grafts. Nevertheless little consensus exists on the optimal antithrombotic agents. The paper reviews publications on the problem. Oral anticoagulants seem to be feasible for reconstructions with poor outflow. In such cases strict laboratory monitoring of blood coagulation system is mandatory to prevent hemorrhagic complications.
Pokrovskiĭ
A V
AV
Department of Vascular Surgery, A. V. Vishnevsky Institute of Surgery, Russian Academy of Medical Science, Moscow, Russia.
Dan
V N
VN
Sapelkin
S V
SV
Perisaev
G A
GA
Kharazov
A F
AF
D000284:Administration, Oral; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply*; D011182:Postoperative Care; D019651:Plastic Surgery Procedures / Q000379:methods; D020246:Venous Thrombosis / Q000503:physiopathology / Q000517:prevention & control* / Q000601:surgery*; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D014859:Warfarin; D001241:Aspirin