Mechanisms of antibiotic neurotoxicity in renal failure.
Neurological complications of antibiotics are relatively common in renal failure. Central nervous system neurotoxicity due to penicillin and beta-lactam antibiotics is best documented with fewer accounts of ototoxicity, peripheral nerve toxicity and neuromuscular blockade. In the context of risk stratification, the goal of this review is to explore the mosaic of factors in renal impairment that may contribute to susceptibility to antibiotic neurotoxicity. Improved knowledge of the pathogenesis of these formidable adverse events among the renal failure subjects should help prevent antibiotic neurotoxicity in the future.
Chow
Kai Ming
KM
Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Szeto
Cheuk Chun
CC
Hui
Andrew Che-Fai
AC
Li
Philip Kam-Tao
PK
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002490:Central Nervous System / Q000187:drug effects*; D007758:Ear, Inner / Q000187:drug effects; D006801:Humans; D009469:Neuromuscular Junction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects; D051437:Renal Insufficiency / Q000188:drug therapy*
D000900:Anti-Bacterial Agents