Efficacies of amphotericin B (AMB) lipid complex, AMB colloidal dispersion, liposomal AMB, and conventional AMB in treatment of murine coccidioidomycosis.
The therapeutic efficacy of three lipid formulations of amphotericin B was compared with that of conventional amphotericin B in treatment of murine coccidioidomycosis. All treatments prolonged survival compared with the no-treatment group (P < 0.0001). Although conventional amphotericin B was more active than lipid formulations on reducing quantitative fungal load on a milligram-per-kilogram basis (P < 0.003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis.
González
Gloria M
GM
Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 78229-3900, USA. gmglez@yahoo.com.mx
Tijerina
Rolando
R
Najvar
Laura K
LK
Bocanegra
Rosie
R
Rinaldi
Michael G
MG
Graybill
John R
JR
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003045:Coccidioides / Q000187:drug effects; D003047:Coccidioidomycosis / Q000188:drug therapy* / Q000382:microbiology; D003102:Colloids; D015169:Colony Count, Microbial; D004337:Drug Carriers; D008081:Liposomes; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D013154:Spleen / Q000382:microbiology; D016019:Survival Analysis
D000935:Antifungal Agents; D003102:Colloids; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B