title: [Ectopic hormone-producing tumors--research and clinics].
abstract: Recent progress in endocrinology, cytokine research, and oncology has provided new information for further understanding of ectopic hormone-producing tumors. The mechanisms responsible for this morbidity need further investigations to clarify the neuroendocrine nature of tumor cells. Meanwhile, a common hormonal substance produced by a specific tumor could serve as a specific tumor marker for the tumor, as is the case of ProGRP for small cell lung cancer. The development of drugs for ectopic hormonal syndrome might be a good lesson of the molecular targeting for hormone signaling pathways. It is reasonable to postulate that the clinical entities covered by the term 'ectopic humoral syndrome' will be increasing.
authors.affiliation: Shizuoka Cancer Center.
authors.forename: Ken
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D016503:Drug Delivery Systems; D015195:Drug Design; D006729:Hormones, Ectopic / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis / Q000209:etiology; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000032:analysis; D011994:Recombinant Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D006729:Hormones, Ectopic; D010446:Peptide Fragments; D010455:Peptides; D011994:Recombinant Proteins; C087079:pro-gastrin-releasing peptide (31-98)