title: Treatment of uncontrolled hemorrhagic shock after liver trauma: fatal effects of fluid resuscitation versus improved outcome after vasopressin.
abstract: In a porcine model of uncontrolled hemorrhagic shock, we evaluated the effects of vasopressin versus an equal volume of saline placebo versus fluid resuscitation on hemodynamic variables and short-term survival. Twenty-one anesthetized pigs were subjected to severe liver injury. When mean arterial blood pressure was <20 mm Hg and heart rate decreased, pigs randomly received either vasopressin IV (0.4 U/kg; n = 7), an equal volume of saline placebo (n = 7), or fluid resuscitation (1000 mL each of lactated Ringer's solution and hetastarch; n = 7). Thirty minutes after intervention, surviving pigs were fluid resuscitated while bleeding was surgically controlled. Mean (+/- SEM) arterial blood pressure 5 min after the intervention was significantly (P < 0.05) higher after vasopressin than with saline placebo or fluid resuscitation (58 +/- 9 versus 7 +/- 3 versus 32 +/- 6 mm Hg, respectively). Vasopressin improved abdominal organ blood flow but did not cause further blood loss (vasopressin versus saline placebo versus fluid resuscitation 10 min after intervention, 1343 +/- 60 versus 1350 +/- 22 versus 2536 +/- 93 mL, respectively; P < 0.01). Seven of 7 vasopressin pigs survived until bleeding was controlled and 60 min thereafter, whereas 7 of 7 saline placebo and 7 of 7 fluid resuscitation pigs died (P < 0.01). We conclude that vasopressin, but not saline placebo or fluid resuscitation, significantly improves short-term survival during uncontrolled hemorrhagic shock.
  
  
  CONCLUSIONS
  Although IV fluid administration is the mainstay of nonsurgical management of trauma patients with uncontrolled hemorrhagic shock, the efficacy of this strategy has been discussed controversially. In this animal model of severe liver trauma with uncontrolled hemorrhagic shock, vasopressin, but not saline placebo or fluid resuscitation, improved short-term survival.
authors.affiliation: Departments of *Anesthesiology and Critical Care Medicine and †Surgery, Leopold-Franzens-University, Innsbruck, Austria.
authors.forename: Claus
authors.initials: C
authors.lastname: Raedler
authors.forename: Wolfgang G
authors.initials: WG
authors.lastname: Voelckel
authors.forename: Volker
authors.initials: V
authors.lastname: Wenzel
authors.forename: Anette C
authors.initials: AC
authors.lastname: Krismer
authors.forename: Christian A
authors.initials: CA
authors.lastname: Schmittinger
authors.forename: Holger
authors.initials: H
authors.lastname: Herff
authors.forename: Viktoria D
authors.initials: VD
authors.lastname: Mayr
authors.forename: Karl H
authors.initials: KH
authors.lastname: Stadlbauer
authors.forename: Karl H
authors.initials: KH
authors.lastname: Lindner
authors.forename: Alfred
authors.initials: A
authors.lastname: Königsrainer
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008107:Liver Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D012151:Resuscitation / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D015996:Survival Rate; D013552:Swine; D016896:Treatment Outcome; D014667:Vasopressins / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014667:Vasopressins