title: Towards whole-organ modelling of tumour growth.
abstract: Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework which can be developed into a fully integrative model for cancer growth. The model takes account of vascular adaptation and cell-cycle dynamics. We explore the effects of spatial inhomogeneity induced by the blood flow through the vascular network and of the possible effects of p27 on the cell cycle. We show how the model may be used to investigate the efficiency of drug-delivery protocols.
authors.affiliation: Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St Giles', Oxford OX1 3LB, UK. t.alarcon@cs.ucl.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Alarcón
authors.forename: H M
authors.initials: HM
authors.lastname: Byrne
authors.forename: P K
authors.initials: PK
authors.lastname: Maini
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002455:Cell Division; D015687:Cell Hypoxia; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009367:Neoplasm Staging / Q000379:methods; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism*; D014781:Viscera / Q000098:blood supply* / Q000503:physiopathology*
chemical_list: D010100:Oxygen