Sperm DNA damage and its clinical relevance in assessing reproductive outcome.
The routine examination of semen, which assesses sperm concentration, percentage motility and morphology, does not identify subtle defects in sperm chromatin architecture. The focus on the genomic integrity of the male gamete has intensified recently due to the growing concern that genetic diseases may be transmitted via assisted reproductive techniques (ART). Accordingly, the intent of this review is to describe the details of the information pertaining to mitochondrial/nuclear sperm DNA damage with an emphasis on its clinical significance and its relationship with male infertility. Assessment of sperm DNA damage appears to be a potential tool for evaluating semen samples prior to their use in ART. Testing DNA integrity may help select spermatozoa with intact DNA or with the least amount of DNA damage for use in assisted conception. In turn, this may alleviate the financial, social and emotional problems associated with failed ART attempts.
Sharma
R K
RK
Center for Advanced Research in Human Reproduction, Infertility and Sexual Function, Glickman Urological Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A19.1, Cleveland, OH 44195, USA.
Said
T
T
Agarwal
A
A
D000328:Adult; D004249:DNA Damage; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000473:pathology*; D008297:Male; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D027724:Reproductive Techniques, Assisted; D013094:Spermatozoa / Q000473:pathology / Q000502:physiology*; D016896:Treatment Outcome