title: Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.
abstract: A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure-activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, PO Box 1005, Kirkland, QC, Canada H9R 4P8. christian_beaulieu@merck.com
authors.forename: Christian
authors.initials: C
authors.lastname: Beaulieu
authors.forename: Zhaoyin
authors.initials: Z
authors.lastname: Wang
authors.forename: Danielle
authors.initials: D
authors.lastname: Denis
authors.forename: Gillian
authors.initials: G
authors.lastname: Greig
authors.forename: Sonia
authors.initials: S
authors.lastname: Lamontagne
authors.forename: Gary
authors.initials: G
authors.lastname: O'Neill
authors.forename: Deborah
authors.initials: D
authors.lastname: Slipetz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wang
mesh_terms: D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D001562:Benzimidazoles / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D001667:Binding, Competitive / Q000187:drug effects; D006801:Humans; D011485:Protein Binding / Q000187:drug effects; D011869:Radioligand Assay; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; D001562:Benzimidazoles; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C036293:prostaglandin D2 receptor