Class I and class II MHC polymorphisms in Mexican patients with Behçet's disease.
Behçet's disease is a multi-system inflammatory disorder of unknown etiology. The disease is more prevalent in Eastern Mediterranean countries and Japan where there is a linkage to HLA-B51. Mexican Mestizos are suitable subjects for studying the role of ethnicity in the susceptibility to Behçet's disease. High-resolution HLA class I and class II typing was performed by polymerase chain reaction sequence-specific oligonucleotide (PCR-SSO) reverse dot blot and PCR-single-strand polymorphism in 32 patients with Behçet's disease and 99 healthy ethnically-matched controls. A significant increased frequency of HLA-B(*)44 (P = 0.02; OR = 2.78; CI 95% = 1.1-7.7), HLA-B(*)52 (P = 0.02; OR = 5.33; CI 95% = 1.07-29.1), and HLA-B(*)56 (P = 0.003; OR = 4.19; CI 95% = 3.37-5.21) as well as HLA-DRB1(*)01 and HLA-DRB1(*)13 (p = 0.007; OR = 3.36; CI 95% = 1.22-9.27) was found in Mexican patients with Behçet's disease when compared to controls. The low frequency of native markers in Mexican Mestizo patients with Behçet's disease suggests that genetic admixture between Eastern Mediterraneans and Orientals with Amerindians is a recent event that increased the risk of developing Behçet's disease in the Mexican population.
Soto-Vega
Elena
E
Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Tlalpan 14000, México, D.F., Mexico.
García-Muñoz
Ricardo
R
Richaud-Patin
Yvonne
Y
Zúñiga-Ramos
Joaquín
J
Crispín
José Carlos
JC
Díaz-Jouanen
Efraín
E
Flores-Suárez
Luis Felipe
LF
Llorente
Luis
L
Granados
Julio
J
D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000208:ethnology / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics*; D005802:Genes, MHC Class II / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
D015235:HLA-B Antigens; C056079:HLA-B56 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains