title: Gastroparesis following kidney/pancreas transplant.
abstract: This pilot study examined associations among patterns of gastric myoelectrical activity, symptoms of gastroparesis, years of diabetes, months of dialysis, and use of gastrointestinal medications in gastroparetic kidney-pancreas (KP) transplant recipients. Electrogastrography (EGG) and gastric symptom data were obtained from 42 transplant recipients before and after transplant (6, 12, and 24 months). Recipients were 38 +/- 7 yr of age, 88% Whites, and 60% male; 97% had hypertension. All had functioning grafts post-transplant (mean creatinine, 1.59 +/- 0.66 mg/dL, and serum glucose 91.97 +/- 24.92 mg/dL). Sixteen subjects had normal EGG (2.7-3.2 cycles per minute, cpm); two were tachygastric (>3.2 cpm) at all time points; one remained bradygastric (<2.7 cpm) throughout the study period. Following transplant, symptoms lessened and were associated with 6-month normalization of EGG (r = 0.41, p = 0.02). A small change in the percentage of patients with normal EGG was observed from baseline to 24 months (67% vs. 69% respectively); however, there was a shift from bradygastria (29% to 15% respectively) to tachygastria (5% to 15% respectively). Prescribed prokinetic and antisecretory medications use increased over the study period from 13 (31%) subjects at baseline to 32 (86%) at 6 months; 21 (78%) at 12 months; and 12 (92%) at 24 months. Although symptoms diminish following transplant, gastroparesis remains a significant problem for transplant patients. Normalization of EGG and shifts from bradygastria to tachygastria occur post-transplant. Our results suggest that serial EGGs and frequent assessment of symptoms can be used to follow gastroparesis in KP recipients.
authors.affiliation: College of Nursing, University of TN Health Science Center, Memphis, TN, USA. acashion@utmem.edu
authors.forename: A K
authors.initials: AK
authors.lastname: Cashion
authors.forename: S L
authors.initials: SL
authors.lastname: Holmes
authors.forename: D K
authors.initials: DK
authors.lastname: Hathaway
authors.forename: A O
authors.initials: AO
authors.lastname: Gaber
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology* / Q000601:surgery; D003956:Dialysis; D004568:Electrodiagnosis / Q000379:methods; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D018589:Gastroparesis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating / Q000502:physiology; D016035:Pancreas Transplantation / Q000009:adverse effects*; D010865:Pilot Projects
chemical_list: D005765:Gastrointestinal Agents