Transgenic tagging defining pancreatic pedigrees.
In this review, analyses of the ontogenetic relations between the different pancreatic cell types are summarized. Lineage analyses allow identification of progenitor cells from which mature cell types differentiate. This knowledge is highly relevant for future cell replacement therapies in diabetic patients, helping to define the identity of putative pancreatic stem cells.
Herrera Merino
Pedro Luis
PL
Department of Genetic Medicine and Development, University of Geneva Medical School, CH-1211 Geneva 4, Switzerland. Pedro.Herrera@medecine.unige.ch
D000818:Animals; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D010179:Pancreas / Q000502:physiology*; D010375:Pedigree