Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein.
The influence of vitamin B6 on fatty acids content in serum and liver of rats receiving low protein diets was studied. Addition of B6 decreased linoleic acid (LA) and increased alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) in serum of rats fed a protein-deficient diet (9% energy from proteins) for 3 months. Further restriction of dietary protein (4.5% of energy from protein) caused an increase of the DHA concentration and sum of polyunsaturated fatty acids (PUFAs). In the liver of undernourished rats significant changes of PUFA composition were noticed, although without any significant influence of vitamin B6.
Bertrandt
Jerzy
J
Military Institute of Hygiene and Epidemiology, Warsaw, Poland. J.Bertrandt@wihe.waw.pl
Klos
Anna
A
Debski
Bogdan
B
D000818:Animals; D018753:Diet, Protein-Restricted; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000378:metabolism; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000378:metabolism*; D019787:Linoleic Acid / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000494:pharmacology*; D017962:alpha-Linolenic Acid / Q000378:metabolism
D004042:Dietary Fats, Unsaturated; D004044:Dietary Proteins; D005231:Fatty Acids, Unsaturated; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D025101:Vitamin B 6; D019787:Linoleic Acid