Lipid rafts in lymphocyte activation.
The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation. In this review, we discuss the recent literature suggesting that, during lymphocyte activation and chemotaxis, lipid rafts act as platforms to compartmentalise signalling and facilitate specific protein-protein interactions.
Pizzo
Paola
P
Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I-35121, Italy. paola.pizzo@unipd.it
Viola
Antonella
A
D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D011971:Receptors, Immunologic