title: Favorable response to soft tissue sarcoma therapy in an adolescent with embryonal renal sarcoma.
abstract: Embryonal renal sarcomas were first identified in 1995 among banked tumor samples originally classified as adult Wilms tumor. Few long-term remissions were observed when these rare tumors were treated with chemotherapy usually used for childhood Wilms. Data were collected from the medical record of an adolescent female with embryonal renal sarcoma and treated with sarcoma-directed chemotherapy and radiation. At 66 months following diagnosis, the patient has no evidence of tumor but has experienced severe renal dysfunction and ovarian failure. We believe there is a subset of patients with disseminated embryonal renal sarcoma that respond to intense sarcoma-directed therapy.
authors.affiliation: Department of Pediatrics, Children's Hospital Medical Center of Akron, One Perkins Square, Akron, Ohio 44308, USA.
authors.forename: Trent
authors.initials: T
authors.lastname: Hummel
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Hord
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*