Natural products active against African trypanosomes: a step towards new drugs.
This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp.,T congolense and T vivax) isolated from natural sources and is organized according to the structure of the etabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from he mid-1980s up to June 2003 is reviewed and 89 references are cited.
Hoet
Sara
S
Laboratoire de Pharmacognosie, Unité d'Analyse Chimique et Physico-Chimique des Médicaments, Université Catholique de Louvain, UCL 72.30-CHAM, Av. E. Mounier 72, 1200 Brussels, Belgium. sara.hoet@cham.ucl.ac.be
Opperdoes
Frederik
F
Brun
Reto
R
Quetin-Leclercq
Joëlle
J
D000349:Africa; D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology; D014345:Trypanosoma / Q000187:drug effects*
D000470:Alkaloids; D001688:Biological Products; D010636:Phenols; D011809:Quinones; D013729:Terpenes