title: Durable remission by sobuzoxane in an HIV-seronegative patient with human herpesvirus 8-negative primary effusion lymphoma.
abstract: Primary effusion lymphoma (PEL) is recognized as a unique clinicopathological entity associated with human herpesvirus 8 (HHV-8), and it occurs almost exclusively in human immunodeficiency virus (HIV)-infected individuals. In the majority of PEL cases, Epstein-Barr virus (EBV) has been found in the tumor cells as well. We describe here an elderly HIV seronegative female patient with PEL in the pleura and pericardium not associated with HHV-8 or EBV. Cytologic examinations of the pleural effusion revealed large lymphoma cells with immunophenotypes positive for CD8, CD10, CD19, CD20, CD22, CD24, CD45, and HLA-DR but negative for CD30 and surface immunoglobulin. Chromosome analysis showed complicated abnormalities including add(3)(q27). Immunoglobulin gene rearrangement was detected by Southern blotting; however, c-myc, Bcl-2, and Bcl-6 genes were not rearranged. The patient was treated with a modified CHOP (cyclophosphamide, hydroxydoxorubicin, oncovine, and prednisolone) regimen, and achieved remission. Recurrence of PEL in the pericardium as effusion lymphoma was found 3 months after the discontinuation of CHOP. After approximately 1 year of intermittent multiagent salvage therapy for pericardial recurrences, a treatment that resulted in a partial response, 3 cycles of monotherapy with sobuzoxane were administered. At the time of this report the patient had been free from PEL for more than 18 months without chemotherapy.
authors.affiliation: Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan.
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Inoue
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Tsukasaki
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nagai
authors.forename: Hisashi
authors.initials: H
authors.lastname: Soda
authors.forename: Masao
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004279:DNA, Viral / Q000032:analysis; D018572:Disease-Free Survival; D005260:Female; D018023:HIV Seronegativity; D019288:Herpesvirus 8, Human / Q000235:genetics; D006801:Humans; D010879:Piperazines / Q000008:administration & dosage*; D016066:Pleural Effusion, Malignant / Q000188:drug therapy* / Q000209:etiology; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods*
chemical_list: D004279:DNA, Viral; D010879:Piperazines; C057773:sobuzoxane