Long-term seizure outcome following resective surgery at National Epilepsy Center in Shizuoka, Japan.
We analyzed the seizure outcome of 357 patients who were followed for at least 2 years after resective surgeries; 282 underwent temporal lobe resection and 75 had extratemporal lobe resection. This study confirmed that resective surgery provides sustained, positive benefits with a high seizure-free rate of nearly 80% for most medically refractory patients. In patients with no MRI-detectable lesion who underwent extratemporal lobe resection, however, Engel's class I-II (seizure-free or rare seizures) was achieved in less than 50% of patients. High-resolution MRI should be performed at the early stage of disease in all patients with partial epilepsies. The findings would certainly urge clinicians to actively select surgical intervention.
Mihara
Tadahiro
T
National Epilepsy Center, Shizuoka Medical Institute of Neurological Disorders, Shizuoka, Japan. mihara@szec.hosp.go.jp
Matsuda
Kazumi
K
Tottori
Takayasu
T
Otsubo
Toshiaki
T
Baba
Koichi
K
Nishibayashi
Hiroki
H
Inoue
Yuhshi
Y
Yagi
Kazuichi
K
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000601:surgery*; D005260:Female; D006801:Humans; D007564:Japan; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D012640:Seizures / Q000601:surgery*; D013702:Temporal Lobe / Q000601:surgery; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome