title: Effect of a high-molecular-weight component of cranberry on constituents of dental biofilm.
abstract: BACKGROUND
  Previous studies have shown that high molecular-weight non-dialysable material derived from cranberry juice (NDM) inhibits co-aggregation of a variety of oral bacteria.
  
  
  OBJECTIVE
  In the present study, we examined the effect of NDM on several constituents of the dental biofilm, glucosyltransferase (GTF) and fructosyltransferase (FTF), as well as on the adhesion of Streptococcus sobrinus.
  
  
  RESULTS
  The activity of immobilized and soluble GTF and FTF was inhibited by NDM (P > 0.05). NDM also inhibited adhesion of S. sobrinus to hydroxyapatite (P < 0.05).
  
  
  CONCLUSIONS
  Our results indicate that NDM may affect biofilm formation. One of the proposed mechanisms is via inhibition of extracellular polysaccharide synthesis, which promote the sucrose-dependent adhesion of oral bacteria as S. sobrinus.
authors.affiliation: Institute of Dental Sciences and Department of Prosthodontics, Faculty of Dentistry, Hebrew University-Hadassah, PO Box 12272, Jerusalem, 91120, Israel. dorons@cc.huji.ac.il
authors.forename: Doron
authors.initials: D
authors.lastname: Steinberg
authors.forename: Mark
authors.initials: M
authors.lastname: Feldman
authors.forename: Itzhak
authors.initials: I
authors.lastname: Ofek
authors.forename: Ervin I
authors.initials: EI
authors.lastname: Weiss
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects*; D003956:Dialysis; D004305:Dose-Response Relationship, Drug; D017886:Durapatite; D005964:Glucosyltransferases / Q000378:metabolism; D006602:Hexosyltransferases / Q000378:metabolism; D008970:Molecular Weight; D013295:Streptococcus mutans / Q000187:drug effects*; D016986:Streptococcus sobrinus / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology; D014070:Tooth / Q000382:microbiology*; D029799:Vaccinium macrocarpon / Q000737:chemistry*; D001426:Bacterial Proteins
chemical_list: D017886:Durapatite; D005964:Glucosyltransferases; D006602:Hexosyltransferases; D013395:Sucrose; C021451:inulosucrase; D001426:Bacterial Proteins