title: [The neurobiological bases of obsessive-compulsive disorder and Tourette syndrome].
abstract: OBJECTIVE
  To describe and discuss evidence-based articles on the neurobiology of obsessive-compulsive disorder and Tourette syndrome.
  
  
  METHODS
  A review of the most relevant papers on the phenomenology, neuroanatomy, neuroimaging, genetic and immunological aspects of these two disorders was performed.
  
  
  RESULTS
  Ritualistic behaviors and repetitive thoughts have been extensively studied in the last years. The definitions of obsessive-compulsive disorder and Tourette syndrome emphasize the existence of a continuum of symptoms, with high prevalence in the general population. Neurobiological findings have implicated genetic and immunological factors in the etiology of these two disorders.
  
  
  CONCLUSIONS
  Advances in neuroscience triggered genetic and immunological research studies, allowing new perspectives on the treatment of obsessive-compulsive disorder and Tourette syndrome patients.
authors.affiliation: Programa de Pós-graduação em Distúrbios do Desenvolvimento, Universidade Presbiteriana Mackenzie. mt.mercadante@uol.com.br
authors.forename: Marcos T
authors.initials: MT
authors.lastname: Mercadante
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rosario-Campos
authors.forename: Lucas C
authors.initials: LC
authors.lastname: Quarantini
authors.forename: Fabio P
authors.initials: FP
authors.lastname: Sato
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D005879:Tourette Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy