title: Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates.
abstract: OBJECTIVE
  To assess the significance of cyclo-oxygenase 2 (COX-2) in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  An immunohistochemical study in which 39 patients with LSCC were included.
  
  
  METHODS
  Immunohistochemical staining of the paraffin-embedded tumour tissues was performed using isoform-specific COX-2 polyclonal antisera (Santa Cruz, Calif., USA). COX-2 results were compared with the clinical parameters of the patients.
  
  
  RESULTS
  COX-2 was detected in all tumour tissues. In the normal laryngeal tissue around the tumour area, which served as control, there was no COX-2 staining. There was no relationship between the COX-2 results and the location of the primary tumour, T stage and N stage, survival, recurrence or pulmonary metastases.
  
  
  CONCLUSIONS
  The absence of a relation between COX-2 positivity and clinical parameters may suggest an involvement of COX-2 in laryngeal carcinogenesis. Since COX-2 positivity could be detected in all LSCC specimens studied, COX-2 could serve as a therapeutic target in LSCC.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey. bayazity@yahoo.com
authors.forename: Yildirim A
authors.initials: YA
authors.lastname: Bayazit
authors.forename: Suleyman
authors.initials: S
authors.lastname: Buyukberber
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
authors.forename: Celalettin
authors.initials: C
authors.lastname: Camci
authors.forename: Enver
authors.initials: E
authors.lastname: Ozer
authors.forename: Alper
authors.initials: A
authors.lastname: Sevinc
authors.forename: Metin
authors.initials: M
authors.lastname: Karakok
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Kanlikama
authors.forename: Semih
authors.initials: S
authors.lastname: Mumbuc
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism*; D051546:Cyclooxygenase 2; D019254:Genes, bcl-2 / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D005931:Glottis / Q000378:metabolism; D006801:Humans; D007013:Hypopharynx / Q000378:metabolism; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism*; D007830:Larynx / Q000378:metabolism*; D008565:Membrane Proteins; D008875:Middle Aged; D009367:Neoplasm Staging; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases