title: Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.
abstract: Three new analogs of UK-1 have been synthesized and their efficacies as topoisomerase II inhibitors have been determined. Results show that UK-1 and two of these analogs are catalytic inhibitors of topo II and identifies a critical structure motif necessary for enzyme inhibition.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250, USA.
authors.forename: Ben B
authors.initials: BB
authors.lastname: Wang
authors.forename: Nima
authors.initials: N
authors.lastname: Maghami
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Goodlin
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Smith
mesh_terms: D001583:Benzoxazoles / Q000737:chemistry* / Q000494:pharmacology; D002384:Catalysis / Q000187:drug effects; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D059005:Topoisomerase II Inhibitors
chemical_list: D001583:Benzoxazoles; D004791:Enzyme Inhibitors; D059005:Topoisomerase II Inhibitors; C082787:UK 1; D004250:DNA Topoisomerases, Type II