title: Messenger RNA stability in mitochondria: different means to an end.
abstract: Gene expression is regulated at many stages not merely at the level of transcription. Among the important post-transcriptional processes, RNA turnover has a crucial role. The stability of mRNA in the cytosol of eukarya is increased by the addition of a 3' poly(A) extension. By contrast, this process mediates rapid RNA decay in prokarya. How is mRNA turnover regulated in mitochondria? Their monophyletic, alpha-proteobacterial origin predicts that polyadenylation will induce rapid decay by nucleases and associated factors that are similar to their bacterial ancestors. In this article, however, we report that the regulation of mitochondrial mRNA turnover in diverse species is surprisingly different.
authors.affiliation: IBMP CNRS, 12 rue du Général Zimmer, 67084 Strasbourg Cedex, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Gagliardi
authors.forename: Piotr P
authors.initials: PP
authors.lastname: Stepien
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Temperley
authors.forename: Robert N
authors.initials: RN
authors.lastname: Lightowlers
authors.forename: Zofia M A
authors.initials: ZM
authors.lastname: Chrzanowska-Lightowlers
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D009690:Nucleic Acid Conformation; D011061:Poly A / Q000235:genetics; D026723:Polyadenylation; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics*; D000077278:RNA, Mitochondrial; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; C029305:mitochondrial messenger RNA; D011061:Poly A