Cyclo-oxygenase 2 expression in laryngeal squamous cell carcinoma and its clinical correlates.
OBJECTIVE
To assess the significance of cyclo-oxygenase 2 (COX-2) in laryngeal squamous cell carcinoma (LSCC).


METHODS
An immunohistochemical study in which 39 patients with LSCC were included.


METHODS
Immunohistochemical staining of the paraffin-embedded tumour tissues was performed using isoform-specific COX-2 polyclonal antisera (Santa Cruz, Calif., USA). COX-2 results were compared with the clinical parameters of the patients.


RESULTS
COX-2 was detected in all tumour tissues. In the normal laryngeal tissue around the tumour area, which served as control, there was no COX-2 staining. There was no relationship between the COX-2 results and the location of the primary tumour, T stage and N stage, survival, recurrence or pulmonary metastases.


CONCLUSIONS
The absence of a relation between COX-2 positivity and clinical parameters may suggest an involvement of COX-2 in laryngeal carcinogenesis. Since COX-2 positivity could be detected in all LSCC specimens studied, COX-2 could serve as a therapeutic target in LSCC.
Bayazit
Yildirim A
YA
Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey. bayazity@yahoo.com
Buyukberber
Suleyman
S
Sari
Ibrahim
I
Camci
Celalettin
C
Ozer
Enver
E
Sevinc
Alper
A
Karakok
Metin
M
Kanlikama
Muzaffer
M
Mumbuc
Semih
S
D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism*; D051546:Cyclooxygenase 2; D019254:Genes, bcl-2 / Q000235:genetics; D018773:Genes, erbB-1 / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics; D005931:Glottis / Q000378:metabolism; D006801:Humans; D007013:Hypopharynx / Q000378:metabolism; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism*; D007830:Larynx / Q000378:metabolism*; D008565:Membrane Proteins; D008875:Middle Aged; D009367:Neoplasm Staging; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics* / Q000378:metabolism*
D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases