title: A modular and concise total synthesis of (+/-)-daurichromenic acid and analogues.
abstract: A modular and concise total synthesis of (+/-)-daurichromenic acid has been accomplished in four steps from ethyl acetoacetate, ethyl crotonate, and trans,trans-farnesal. A series of analogues of this natural product, which has potent anti-HIV activity, were also prepared from ethyl or methyl acetoacetate and a series of readily available alpha,beta-unsaturated esters and aldehydes.
authors.affiliation: Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6.
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Hu
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: Harrison
authors.forename: Peter D
authors.initials: PD
authors.lastname: Wilson
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002839:Chromans / Q000138:chemical synthesis*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; D002839:Chromans; C489925:daurichromenic acid