title: Alterations in chemokine expression following Theiler's virus infection and restraint stress.
abstract: Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1 beta, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.
authors.affiliation: Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.
authors.forename: W
authors.initials: W
authors.lastname: Mi
authors.forename: M
authors.initials: M
authors.lastname: Belyavskyi
authors.forename: R R
authors.initials: RR
authors.lastname: Johnson
authors.forename: A N
authors.initials: AN
authors.lastname: Sieve
authors.forename: R
authors.initials: R
authors.lastname: Storts
authors.forename: M W
authors.initials: MW
authors.lastname: Meagher
authors.forename: C J R
authors.initials: CJ
authors.lastname: Welsh
mesh_terms: D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology / Q000821:virology; D018188:Cardiovirus Infections / Q000276:immunology* / Q000503:physiopathology; D018925:Chemokines / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000032:analysis; D012149:Restraint, Physical; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000821:virology; D013315:Stress, Psychological / Q000276:immunology*; D017945:Theilovirus / Q000378:metabolism*; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: D018925:Chemokines; D012333:RNA, Messenger