title: Correction of anemia in patients with congestive heart failure increases resting energy expenditure.
abstract: OBJECTIVE
  Congestive heart failure (CHF) and anemia were reported to affect resting energy expenditure (REE). The aim of this study was to evaluate the effect of the correction of anemia on REE in subjects with CHF.
  
  
  METHODS
  Nine anemic patients with compensated CHF and CRF were studied before and after correction of anemia. REE was studied by an open circuit indirect calorimeter, body composition by dual-energy-X-ray absorption and total body and extracellular water by multi-frequency bioelectrical impedence. Four anemic and 5 non-anemic CHF patients who did not receive any new treatment served as controls.
  
  
  RESULTS
  After the correction of their anemia patients tended to increase weight (P<0.06), but no significant changes were observed in body composition. Daily caloric intake increased significantly (P<0.02). Ejection fraction increased (P<0.05) and pulse rate decreased significantly (P<0.001). REE and REEPP were in the normal range before correction but increased significantly afterwards (1402+/-256 vs. 1496+/-206 kcal/d, and 101+/-9 vs. 109+/-8, P<0.023 and P<0.006, respectively).
  
  
  CONCLUSIONS
  Correction of anemia in patients with CHF increases their REE. This can be related either to improved tissue oxygenation and/or to increased caloric intake.
authors.affiliation: Unit of Clinical Nutrition, Tel-Aviv Sourasky Medical Centre, 6 Weizman Street, Tel-Aviv 64239, Israel. vaisman@agri.huji.ac.il
authors.forename: N
authors.initials: N
authors.lastname: Vaisman
authors.forename: D S
authors.initials: DS
authors.lastname: Silverberg
authors.forename: D
authors.initials: D
authors.lastname: Wexler
authors.forename: E
authors.initials: E
authors.lastname: Niv
authors.forename: M
authors.initials: M
authors.lastname: Blum
authors.forename: G
authors.initials: G
authors.lastname: Keren
authors.forename: N
authors.initials: N
authors.lastname: Soroka
authors.forename: A
authors.initials: A
authors.lastname: Iaina
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D001481:Basal Metabolism / Q000502:physiology*; D001823:Body Composition / Q000502:physiology*; D002153:Calorimetry, Indirect; D017097:Electric Impedance; D002149:Energy Intake; D004921:Erythropoietin / Q000627:therapeutic use; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000378:metabolism*; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D015430:Weight Gain
chemical_list: D004921:Erythropoietin; D007501:Iron