title: [Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage].
authors.affiliation: Department of Cell Pharmacology, Nagoya University Graduate School of Medicine.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakayama
authors.forename: Mutsuki
authors.initials: M
authors.lastname: Amano
authors.forename: Saeko
authors.initials: S
authors.lastname: Kawabata
authors.forename: Kozo
authors.initials: K
authors.lastname: Kaibuchi
authors.forename: Mikihito
authors.initials: M
authors.lastname: Takefuji
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000577:Amides / Q000494:pharmacology / Q000627:therapeutic use; D000787:Angina Pectoris / Q000188:drug therapy / Q000209:etiology*; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000209:etiology*; D002118:Calcium / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D047908:Intracellular Signaling Peptides and Proteins; D009119:Muscle Contraction; D009130:Muscle, Smooth; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use; D020741:rho GTP-Binding Proteins / Q000037:antagonists & inhibitors / Q000502:physiology*; D054460:rho-Associated Kinases
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D047908:Intracellular Signaling Peptides and Proteins; D011725:Pyridines; C108830:Y 27632; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases; D009219:Myosin-Light-Chain Kinase; D020741:rho GTP-Binding Proteins; C049347:fasudil; D002118:Calcium