Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development?
Transgenic mice have been created in an attempt to generate models of human Alzheimer's disease, but success has been partial and unpredictable. The overall aim of this paper is to illustrate how genomics can be used in translational research, turning genetic information in the form of pathogenic mutations into clinically useful drugs against a major human disease. This paper will illustrate how genetic information allows researchers to dissect the aetiology of a disease and then replicate the disease in vivo through the process of transgenesis. The limitations of recreating a condition like Alzheimer's disease in a transgenic mouse, how far the mice have advanced understanding of the disease and how useful they have been for the development of therapeutics will then be discussed.
Duff
Karen
K
Nathan Kline Institute, Department of Psychiatry, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA. duff@nki.rfmh.org
Suleman
Faraha
F
D000544:Alzheimer Disease / Q000235:genetics* / Q000628:therapy*; D016229:Amyloid beta-Peptides / Q000235:genetics; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation
D016229:Amyloid beta-Peptides