title: Lack of association between angiotensin I-converting enzyme insertion/deletion gene functional polymorphism and panic disorder in humans.
abstract: Family and twin studies have indicated that genes influence susceptibility to panic disorder, but the genes involved remain unknown. The neuropeptide angiotensin II has been found to be involved in anxiety and regulation of respiration which are important in the pathophysiology of panic attacks. Assuming that angiotensins may be candidate genes in panic disorder, we analyzed the association between panic disorder and angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) gene functional polymorphism. We recruited 101 patients with panic disorder diagnosed according to DSM-IV criteria, and 184 control subjects in the study. No significant differences in the frequency of the genotype or allele in the polymorphism between patient and control groups were found (genotype, chi(2)=0.56, d.f.=2, P=0.77; allele, chi(2)=0.074, d.f.=1, P=0.78). This study suggests that the ACE I/D gene polymorphism is not directly associated with panic disorder in our Japanese patient group.
authors.affiliation: Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. eiji@faculty.chiba-u.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Shimizu
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Mitsumori
authors.forename: Shintaro
authors.initials: S
authors.lastname: Ohgake
authors.forename: Hiroki
authors.initials: H
authors.lastname: Koizumi
authors.forename: Naoe
authors.initials: N
authors.lastname: Okamura
authors.forename: Kaori
authors.initials: K
authors.lastname: Koike
authors.forename: Chikara
authors.initials: C
authors.lastname: Kumakiri
authors.forename: Michiko
authors.initials: M
authors.lastname: Nakazato
authors.forename: Naoya
authors.initials: N
authors.lastname: Komatsu
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
mesh_terms: D000328:Adult; D000483:Alleles; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional; D016584:Panic Disorder / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion
chemical_list: D007703:Peptidyl-Dipeptidase A