title: FMRI of brain activation in a genetic rat model of absence seizures.
abstract: OBJECTIVE
  EEG-triggered functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during spontaneous spike-and-wave discharges (SWDs) in an epileptic rat strain under awake conditions.
  
  
  METHODS
  Spontaneous absence seizures from 10 WAG/Rij rats were imaged by using T2*-weighted echo planar imaging at 4.7 Tesla. fMRI of the blood-oxygenation-level-dependent (BOLD) signal was triggered based on EEG recordings during imaging. Images obtained during spontaneous SWDs were compared with baseline images.
  
  
  RESULTS
  Significant positive BOLD signal changes were apparent in several areas of the cortex and several important nuclei of the thalamus. In addition, no negative BOLD signal was found in any brain area.
  
  
  CONCLUSIONS
  We have shown that EEG-triggered BOLD fMRI can be used to detect cortical and thalamic activation related to the spontaneous SWDs that characterize absence seizures in awake WAG/Rij rats. These results draw an anatomic correlation between areas in which increased BOLD signal is found and those in which SWDs have been recorded. In addition, no negative BOLD signal was found to be associated with these spontaneous SWDs. We also demonstrated the technical feasibility of using EEG-triggered fMRI in a genetic rat model of absence seizure.
authors.affiliation: Center for Comparative Neuroimaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. jeffrey.tenney@umassmed.edu
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Tenney
authors.forename: Timothy Q
authors.initials: TQ
authors.lastname: Duong
authors.forename: Jean A
authors.initials: JA
authors.lastname: King
authors.forename: Craig F
authors.initials: CF
authors.lastname: Ferris
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013787:Thalamic Nuclei / Q000503:physiopathology
chemical_list: D010100:Oxygen