Changes in blood viscosity with mucopolysaccharide polysulfate.
We examined the dose-dependent effects of mucopolysaccharide polysulfate (MPS) on coagulation variables and whole-blood viscosity in human blood. Both 0.01% and 0.1% MPS significantly reduced levels of both fibrin monomer and thrombin-antithrombin III complex in a manner similar to that of 2.0 IU/ml heparin sodium. Furthermore, MPS dose-dependently decreased whole-blood viscosity, as measured with an oscillation viscometer. Because MPS can be applied in creams and gels, percutaneous application of MPS may effectively reduce whole-blood viscosity in local veins.
Hitosugi
Masahito
M
Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan. hitosugi@dokkyomed.ac.jp
Omura
Kazunobu
K
Kido
Masahito
M
Kawato
Hitoshi
H
Niwa
Munehiro
M
Nagai
Toshiaki
T
Tokudome
Shogo
S
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D001809:Blood Viscosity / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006801:Humans; D008297:Male
D006025:Glycosaminoglycans; C052717:mucopolysaccharide polysulfate