title: [Hormone production and secretion in thyroid tumors].
abstract: Thyroid epithelial cells can be classified into 2 types according to embryonic origin, those of foregut endoderm (follicular cells) and those of neuroectodermal deviation (C cells) origin. The production of TG, T4, and T3 is frequently evident with the immunoperoxidase methods is nontoxic thyroid tumors derived from follicular cells. In contrast, medullary thyroid carcinoma originated from thyroid C cells produces and secretes calcitonin. Thyroid transcription factor-1 (TTF-1) regulates the expression of all hormones produced in thyroid. In recent years, evidence has been accumulating for the existence of a tumor group with traits of both follicular and medullary carcinoma, designated as mixed follicular and medullary carcinoma.
authors.affiliation: Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi.
authors.forename: Ryohei
authors.initials: R
authors.lastname: Katoh
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kondo
authors.forename: Shinichi
authors.initials: S
authors.lastname: Murata
mesh_terms: D002116:Calcitonin / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology; D013963:Thyroid Hormones / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism*; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000502:physiology
chemical_list: C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D013963:Thyroid Hormones; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D002116:Calcitonin