[Preparation of all-trans retinoic acid mixed micelles injection].
OBJECTIVE
To increase the solubility and bioavailability of all-trans retinoic acid (ATRA).


METHODS
Using the principle of lecthin/bile salt mixed micelle to prepared ATRA injection. The best formulation was obtained by the turbidity and three-phase figure.


RESULTS
ATRA mixed micelles injection is stable. The average size of the mixed micelle is 17.8 nm, poly. index 0.495, zeta potential -16.5 mV.


CONCLUSIONS
The method can be used to prepare the stable injection.
Zhu
Lin
L
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China. kfzl@hotmail.com
Zhu
Jia-bi
JB
Tu
Ying
Y
Tian
Xu
X
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D001647:Bile Acids and Salts; D004355:Drug Stability; D008823:Micelles; D010713:Phosphatidylcholines; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D014212:Tretinoin / Q000008:administration & dosage* / Q000737:chemistry
D000970:Antineoplastic Agents; D001647:Bile Acids and Salts; D008823:Micelles; D010713:Phosphatidylcholines; D014212:Tretinoin