[Effects of glutamine granules on protein metabolism in trauma patients].
OBJECTIVE
To evaluate the effect of glutamine granules on protein metabolism in severe burns and trauma patients.


METHODS
120 patients with severe burns, multiple trauma and post operation who met the requirements of the protocol joined this double-blind randomized controlled, multi-center clinical trail. Patients were randomly divided into two groups: placebo control group (P group, 60 patients) and glutamine granules treatment group (GLN group, 60 patients). There was isonitrogenous and isocaloric intake in both groups, GLN and P group patents had been given glutamine granules or placebo (glycine) at 0.5 g.kg(-1).d(-1) for 7 days, respectively. The level of plasma glutamine, protein and urine nitrogen exclude were determined, wound healing rate of burn area and hospital stay were recorded, and then observed the complication and side effect.


RESULTS
After 7 days of taking glutamine granules orally, plasma GLN concentration was significant higher than that in P group (592.50 +/- 185.23 micro mol/L vs. 407.41 +/- 190.22 micro mol/L) (P < 0.01). Plasma prealbumin and transferrin in GLN group were significant higher than those in P group (P < 0.01), but the concentration of total protein and albumin were no marked changes compare with P group (P > 0.05). The capacity of urine nitrogen exclude in GLN group were significant lower than that in P group. Additional, the wound healing rate was faster and hospital stay days was shorter than P group (P < 0.05), and the occurrence of glutamine granules side effect was seldom.


CONCLUSIONS
Taking glutamine could promote protein synthesis, abate protein decompose, ameliorate wound healing rate and reduce hospital stay obviously.
Peng
Xi
X
Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China.
You
Zhong-yi
ZY
Huang
Xian-kai
XK
Zhang
Shao-quan
SQ
He
Guang-zhao
GZ
Xie
Wei-guang
WG
Quan
Zhu-fu
ZF
D000328:Adult; D002056:Burns / Q000188:drug therapy / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005973:Glutamine / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000652:urine; D011506:Proteins / Q000378:metabolism; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000378:metabolism
D011506:Proteins; D005973:Glutamine; D009584:Nitrogen