Genomics and proteomics tools for compound mode-of-action studies in drug discovery.
A broad range of genomics and proteomics technologies are increasingly being integrated into emerging research fields such as pharmacogenomics, pharmacoproteomics, chemogenomics, chemical genetics, and chemical biology. Here we review applications of genomic and proteomic technologies to drug mechanism-of-action studies and how these are beginning to impact the drug discovery process.
Kley
Nikolai
N
GPC Biotech, Inc, 610 Lincoln Street, Waltham MA 02451, USA. nikolai.kley@ gpc-biotech.com
Ivanov
Igor
I
Meier-Ewert
Sebastian
S
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D015195:Drug Design; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D040901:Proteomics / Q000379:methods* / Q000639:trends