[The clinical significance of saliva beta(2)-m in patients with head and neck tumors]
The detection of serum beta(2)-microglobulin is presently used as a marker for malignant tumors.The present paper reports that the quantity of beta(2)-microglobulin in the saliva from patients with head and neck tumors was detected by radioimmunity.The results indicates that the amounts of beta(2)-microglobulin in the saliva of patients with benign tumors(1.58micro/ml) were significantly lower than ones of patients with malignant tumors(2.89micro/ml),but similar with ones of normal patients(1.68micro/ml). beta(2)-microglobulin had the specific immunogenecity and was possibly linked with immunity.The cells of malignant tumors excreted relatively higher amounts of beta(2)-microglobulin.This might result from t he synthesization of the cells of malignant tumors and the increase of excreted beta(2)-microglobulin,or the direct entry of beta(2)-microglobulin excreted in the malignant tumors at head and neck into saliva and the infiltration of tumor cells into saliva and infiltration of tumor cells into the salivary glands.beta(2)-microglobulin in saliva appeared with serum.Thus,The detection of beta(2)-microglobulin in saliva is considered as a supplementary method for the diagnosis of tumors.
Chen
J
J
The Second People's Hospital of Hangzhou. Zhejiang 310015,China.
Chen
G F
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