Expression of cyclooxygenase-1 and -2 in canine nasal carcinomas.
Cyclooxygenase-1 (COX-1) and cyclooxygenase -2 (COX-2) are known to play a role in the carcinogenesis of many human and animal primary epithelial tumours. However, expression of COX-1 and -2 has not been investigated in canine nasal epithelial carcinoma, a rare form of neoplasia. COX-1 immunolabelling was demonstrated in normal canine nasal mucosa and in a minority of neoplastic specimens. Cytoplasmic COX-2, however, was strongly expressed in the majority of canine nasal carcinomas. In addition, COX-2 expression was demonstrated in dysplastic epithelium and in a proportion of stromal cells. Co-expression of both enzyme isoforms was revealed by confocal laser scanning microscopy. The results indicate that COX-2 is overexpressed in a proportion of naturally occurring canine nasal carcinomas, suggesting its possible role in canine nasal tumorigenesis.
Borzacchiello
G
G
Universita degli Studi di Napoli Federico II, Dipartimento di Patologia e Sanita Animale, Via F. Delpino, 1, Napoli 80137, Italy.
Paciello
O
O
Papparella
S
S
D000818:Animals; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D018613:Microscopy, Confocal; D009375:Neoplasms, Glandular and Epithelial / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D009669:Nose Neoplasms / Q000201:enzymology / Q000473:pathology / Q000662:veterinary*; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis*
D007527:Isoenzymes; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases