Circadian variation of the efficacy of thrombolytic therapy in acute myocardial infarction-isn't the time ripe for cardiovascular chronotherapy?
This study was designed to assess the circadian variation of the efficacy of thrombolytic therapy (TT) in 163 patients with acute myocardial infarction. Statistical analysis of the results suggests the existence of circadian variation in the efficacy of thrombolytic therapy with marked early morning resistance and significantly better late daytime results. There is a strong relationship between the normal physiologic rhythms of biochemical, hemodynamic, and hematologic parameters, observed in patients with CAD and the circadian fluctuations of efficacy of TT. Obviously the efficacy of TT is influenced by more evident impact of chronorisk factors during the early morning hours.
Reisin
Leonardo H
LH
Cardiology Department, Epidemiology Research Institute, Barzilai Medical Center Campus, Faculty of Health Sciences, Ben-Gurion University of the Negev, Ashkelon, Israel. leonardo@barzi.health.gov.il
Pancheva
Nadya
N
Berman
Michael
M
Khalameizer
Vladimir
V
Jafary
Jamal
J
Yosefy
Chaim
C
Blaer
Yosef
Y
Manevich
Ilia
I
Peled
Ronit
R
Scharf
Shimon
S
D019454:Chronotherapy; D002940:Circadian Rhythm; D004562:Electrocardiography; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D015425:Myocardial Reperfusion; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015912:Thrombolytic Therapy; D016896:Treatment Outcome