title: Eki2 is upregulated specifically in the testis during mouse sex determination.
abstract: We have identified a gene with gonad restricted expression throughout mouse development, which is orthologous to human EKI2 (ethanolamine kinase 2). Our studies showed that mouse Eki2 expression became upregulated in the male gonad during the period of sex determination. Expression was restricted to the Sertoli cells of the developing testis. Eki2 has sequence similarity to ethanolamine (73%) and choline kinases (54%).
authors.affiliation: Murdoch Children's Research Institute, Centre for Hormone Research, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Vic 3052, Australia.
authors.forename: Tanya M
authors.initials: TM
authors.lastname: Hurley
authors.forename: Peter J
authors.initials: PJ
authors.lastname: McClive
authors.forename: Mai A
authors.initials: MA
authors.lastname: Sarraj
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Sinclair
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D013737:Testis / Q000196:embryology / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D017853:Phosphotransferases (Alcohol Group Acceptor); C020125:ethanolamine kinase