Suppression of IgE production and modulation of Th1/Th2 cell response by electroacupuncture in DNP-KLH immunized mice.
Effects of electroacupuncture (EA) on Th1/Th2 cell response were investigated in BALB/c mice immunized intraperitoneally with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH). Successive electroacupuncture stimulation on the ST36 acupoint was performed just after immunization. Serum levels of antigen-specific IgE and total IgE were significantly decreased compared with non-acupunctured controls. Production of the Th2-specific cytokines IL-4 and IL-13 in the anti-CD3 mAb-activated splenocytes was significantly suppressed in ST36 electroacupunctured mice compared with non-acupunctured mice. These results imply that successive electroacupuncture on ST36 can decrease the serum level of antigen-specific IgE and total IgE by suppression of the Th2 lineage development.
Park
Moon-Baik
MB
Chungnoi Clinical Research Center, and Department of Physiology, College of Oriental Medicine, Kyunghee University, Seoul, South Korea.
Ko
Eunjung
E
Ahn
Changjoon
C
Choi
Hyun
H
Rho
Samwoong
S
Shin
Min-Kyu
MK
Hong
Moo-Chang
MC
Min
Byung-Il
BI
Bae
Hyunsu
H
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage; D002478:Cells, Cultured; D004136:Dinitrobenzenes / Q000276:immunology; D015671:Electroacupuncture; D005260:Female; D006433:Hemocyanins / Q000276:immunology*; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis; D018793:Interleukin-13 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D015848:Interleukin-5 / Q000096:biosynthesis; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D018417:Th1 Cells / Q000166:cytology* / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology* / Q000276:immunology
D004136:Dinitrobenzenes; D018793:Interleukin-13; D015848:Interleukin-5; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin