title: Efficacy of topical treatment with aescin + essential phospholipids gel in venous insufficiency and hypertension.
abstract: Aescin and essential phospholipids (AEPL) in a gel was used in a microcirculatory model to assess the effects on skin perfusion in chronic venous insufficiency and severe venous hypertension. The aim of this efficacy study was to evaluate the efficacy of an AEPL gel on the microcirculation measuring transcutaneous skin PO(2) and PCO(2) in subjects with chronic venous insufficiency, venous hypertension (CVH), and venous microangiopathy. Transcutaneous PO(2) and PCO(2) were measured at the internal perimalleolar region. After 2 weeks of treatment with AEPL, all TcPO(2) individual values were increased and all PCO(2) values were decreased (p < 0.05). Average values were significantly changed toward normal. Therefore, considering skin PO(2) and PCO(2) variations, local treatment with AEPL in areas of venous microangiopathy is very effective in improving skin perfusion and nutrition and, possibly, in preventing venous ulcerations.
authors.affiliation: Irvine2 Vascular Laboratory, Department of Biomedical Sciences, G. D'Annunzio University, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Ruffini
authors.forename: G
authors.initials: G
authors.lastname: Belcaro
authors.forename: M R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: M
authors.initials: M
authors.lastname: Dugall
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D002908:Chronic Disease; D004338:Drug Combinations; D004928:Escin / Q000008:administration & dosage*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010713:Phosphatidylcholines / Q000008:administration & dosage*; D012867:Skin / Q000098:blood supply*; D014689:Venous Insufficiency / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D014690:Venous Pressure
chemical_list: D004338:Drug Combinations; D005782:Gels; D010713:Phosphatidylcholines; C011246:essential 303 forte; D002245:Carbon Dioxide; D004928:Escin; D010100:Oxygen