A new approach to the synthesis of optically active alkylated adenine derivatives.
A new synthesis of chiral acyclic nucleoside and nucleotide analogues starting from d(-)- or l(+)-riboses was proposed. Antiviral properties of the synthesized compounds towards the pox virus family were evaluated.
Zakirova
N F
NF
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilov St, Moscow 119991, Russian Federation. naucik@aport2000.ru
Shipitsyn
A V
AV
Belanov
E F
EF
Jasko
M V
MV
D000225:Adenine / Q000138:chemical synthesis* / Q000494:pharmacology; D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002522:Chlorocebus aethiops; D013237:Stereoisomerism; D014709:Vero Cells
D000477:Alkylating Agents; D000998:Antiviral Agents; D000225:Adenine