Relevance of homocysteine on brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness in patients with hypercholesterolemia.
The relevance of homocysteine to brachial flow-mediated vasodilatation and carotid and femoral intima-media thickness was investigated in 192 patients with hypercholesterolemia. Low-density lipoprotein cholesterol and homocysteine levels predicted brachial flow-mediated vasodilatation, internal carotid mean intima-media thickness, and intima-media thickening at all femoral sites. Homocysteine levels seem to be an additional factor in the initial atherosclerotic damage of patients with hypercholesterolemia.
Vaudo
Gaetano
G
Unit of Internal Medicine, Angiology and Arteriosclerosis, University of Perugia School of Medicine, via Brunamonti 51, 06122 Perugia, Italy. gvaudo@unipg.it
Marchesi
Simona
S
Siepi
Donatella
D
Bagaglia
Francesco
F
Paltriccia
Rita
R
Pirro
Matteo
M
Schillaci
Giuseppe
G
Lupattelli
Graziana
G
Mannarino
Elmo
E
D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging* / Q000473:pathology; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005263:Femoral Artery / Q000000981:diagnostic imaging* / Q000473:pathology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D012044:Regression Analysis; D012307:Risk Factors; D017539:Tunica Intima / Q000473:pathology*; D017540:Tunica Media / Q000473:pathology*; D014463:Ultrasonography; D014664:Vasodilation / Q000502:physiology*
D008078:Cholesterol, LDL; D006710:Homocysteine