title: [A case of colon carcinoma with unresectable multiple liver metastases responding to various combined chemotherapies centering on hepatic arterial infusion therapy].
abstract: We have experienced a case of colon carcinoma with unresectable multiple liver metastases responding to various combined chemotherapies centering on hepatic arterial infusion therapy. A 42-year-old female with descending colon carcinoma and synchronous unresectable multiple liver metastases underwent left hemicolectomy in September 2001. She was treated with chemotherapy centering on hepatic arterial infusion (HAI) following implantation of a reservoir in the outpatient setting. Pharmacokinetic modulating therapy (PMC), and HAI with Leucovorin/CDDP/5-FU and Levoforinate/CDDP/5-FU were conducted sequentially. Alternative HAI of 5-FU with intravenous infusion of Levoforinate and systemic irinotecan/CDDP were continued biweekly after release of the hepatic artery occlusion. Liver metastases shrunk after 6 months of treatment and were remarkably decreased in size in May 2003. Although 3 metastatic lesions existed in both lungs, good quality of life has been maintained in the 2 years following surgery.
authors.affiliation: Division of Surgery, Japan Self Defense Force Central Hospital.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Suganuma
authors.forename: Risa
authors.initials: R
authors.lastname: Terauchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shikina
authors.forename: Masafumi
authors.initials: M
authors.lastname: Tanaka
authors.forename: Suefumi
authors.initials: S
authors.lastname: Aozasa
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Utsunomiya
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujino
authors.forename: Hideto
authors.initials: H
authors.lastname: Ito
authors.forename: Kazushige
authors.initials: K
authors.lastname: Okada
authors.forename: Tomoki
authors.initials: T
authors.lastname: Tsuda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hase
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000473:pathology* / Q000601:surgery; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D011788:Quality of Life
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin