[Identification and management of hereditary predisposition to cancer of the breast and the ovary (update 2004)].
BACKGROUND
Since the last recommendations, up to 2,500 new references had been published on that topic.


METHODS
On the behalf of the health Minister, the Ad Hoc Committee consisted of 13 experts carried out a first version revisited by five additional experts who critically analyzed the first version of the report.


METHODS
Breast and ovarian cancer seem to be associated with fewer deleterious mutation of BRCA12 and BRCA2 than previously thought. The screening of ovarian cancer is still not an attractive option while in contrast MRI may be soon for these young women with dense breast, the recommended option for breast cancer screening. The effectiveness of prophylactic surgeries is now well established. French position is to favor such surgeries with regard to a quality of life in line with the expected benefit, and providing precise and standardized process described in the recommendation.


CONCLUSIONS
Due to methodological flaws, the low power and a short follow-up of the surveys, this statement cannot however aspire to a high stability.
Eisinger
François
F
Médecin Interniste Département d'Oncogénétique, Institut Paoli-Calmettes, Inserm E9939, Marseille. eisinger@marseille.inserm.fr
Bressac
Brigitte
B
Castaigne
Damienne
D
Cottu
Pierre-Henri
PH
Lansac
Jacques
J
Lefranc
Jean-Pierre
JP
Lesur
Anne
A
Noguès
Catherine
C
Pierret
Janine
J
Puy-Pernias
Séverine
S
Sobol
Hagay
H
Tardivon
Anne
A
Tristant
Henri
H
Villet
Richard
R
D001943:Breast Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D005602:France; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008408:Mastectomy / Q000379:methods; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D010052:Ovariectomy; D012306:Risk