Porphyrin-DNA cross-linking agent hybrids: chemical synthesis and biological studies.
Three new porphyrin-DNA cross-linking conjugates 8, 9, and 10 have been synthesized. Their photoinduced DNA cleavage activity have been studied. The IC(50) values to THP-1 cells in the presence of porphyrin derivatives 8, 9, and 10 with photoirradiation were 5.6, 88.4, and 61.8 nM, respectively.
He
Hanping
H
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, China.
Tian
Tian
T
Wang
Ping
P
Wu
Lin
L
Xu
Jingjing
J
Zhou
Xiang
X
Zhang
Xiaolian
X
Cao
Xiaoping
X
Wu
Xiaojun
X
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D011166:Porphyrins / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D003432:Cross-Linking Reagents; D011166:Porphyrins; D004247:DNA