Retrograde transport of cholera toxin into the ER of host cells.
Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Here we discuss recent studies on the mechanism of transport from plasma membrane to the ER and on the reactions that unfold and retrotranslocate a portion of the toxin to the cytosol where toxicity is induced.
Lencer
Wayne I
WI
GI Cell Biology, Children's Hospital Boston, Harvard Digestive Diseases Center, Department of Pediatrics Harvard Medical School, Boston, MA 02115, USA. wayne.lencer@tch.harvard.edu
D002462:Cell Membrane / Q000378:metabolism; D002772:Cholera Toxin / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005677:G(M1) Ganglioside / Q000378:metabolism; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism; D021381:Protein Transport
D005677:G(M1) Ganglioside; D002772:Cholera Toxin; D002784:Cholesterol