First total synthesis of structurally unique flavonoids and their strong anti-inflammatory effect.
The first total synthesis of structurally unique flavonoids 1a and 1b is described. These compounds showed very strong anti-inflammatory effect against delayed hypersensitivity in a mouse model.
Nakatsuka
Takashi
T
Daiichi Suntory Biomedical Research Co, Ltd, 1-1-1, Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8513, Japan. takashi_nakatsuka@dsup.co.jp
Tomimori
Yoshiaki
Y
Fukuda
Yoshiaki
Y
Nukaya
Haruo
H
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005419:Flavonoids / Q000138:chemical synthesis* / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids