title: Advantages and disadvantages of surgical therapy and optimal extent of thyroidectomy for the treatment of hyperthyroidism.
abstract: Surgery is excellent therapy for hyperthyroidism, with no mortality,and few complications or recurrences. It achieves euthyroidism rapidly and consistently, avoids long-term risks of radioactive iodine and antithyroid medications, provides tissue for histology,renders childbearing immediately possible, and allows absolute titration of thyroid hormone. Advancements such as preoperative preparation and intraoperative parathyroid hormone monitoring have decreased risks greatly and improved outcomes. Hartley-Dunhill procedure is the treatment of choice. Patients should be rendered euthyroid before operation to decrease thyroid vascularity, to improve surgical planes, and to prevent life threatening thyroid storm. Patients must be monitored carefully for hypocalcemia, a potentially serious complication. Patients will require lifelong thyroid hormone replacement. Radioactive iodine ablation should be considered for disease recurrence after surgery.
authors.affiliation: Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. mboger@wfubmc.edu
authors.forename: M Sean
authors.initials: MS
authors.lastname: Boger
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Perrier
mesh_terms: D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D011183:Postoperative Complications; D013965:Thyroidectomy / Q000009:adverse effects* / Q000379:methods*