title: New insights into the role of Vif in HIV-1 replication.
abstract: HIV-1 and most of the other lentiviruses encode Vif (virion infectivity factor), an accessory protein that the virus requires to replicate in primary CD4+ T-cells and monocytes. The host cell factor with which Vif interacts was recently identified as APOBEC3G, a cytidine deaminase related to the RNA-editing enzymes. Identification of this key host protein has allowed for dramatic leaps in our understanding of how Vif functions. Vif prevents the encapsidation of APOBEC3G into HIV-1 virions during virus assembly. If not for Vif, the encapsidated APOBEC3G would damage the virus reverse transcripts, causing their degradation and closing the open reading frames of its genes.
authors.affiliation: Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
authors.forename: Bärbel
authors.initials: B
authors.lastname: Schröfelbauer
authors.forename: Qin
authors.initials: Q
authors.lastname: Yu
authors.forename: Nathaniel R
authors.initials: NR
authors.lastname: Landau
mesh_terms: D000071480:APOBEC-3G Deaminase; D000818:Animals; D002460:Cell Line; D003564:Cytidine Deaminase; D016346:Gene Products, vif / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D009700:Nucleoside Deaminases; D011506:Proteins / Q000378:metabolism; D012097:Repressor Proteins; D014779:Virus Replication; D054320:vif Gene Products, Human Immunodeficiency Virus
chemical_list: D016346:Gene Products, vif; D011506:Proteins; D012097:Repressor Proteins; D054320:vif Gene Products, Human Immunodeficiency Virus; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase