[Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus].
It was demonstrated by subtractive hybridization that the infection of a human embryonic kidney cell line with tick-borne encephalitis virus causes an approximately tenfold transcription activation of the RIG-1 gene, which encodes a protein of the DExH/D-box-containing RNA helicase family. A possible involvement of the protein in antiviral cell systems is discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.
Monastyrskaia
G S
GS
Shemyakin-Ovchinnikov, Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP Moscow, 117997 Russia. gal@humgen.siobc.ras.ru
Kostina
M B
MB
Filiukova
O B
OB
Protopopova
E V
EV
Konovalova
S N
SN
Kachko
A V
AV
Nikolaev
L G
LG
Loktev
V B
VB
Sverdlov
E D
ED
D001483:Base Sequence; D002460:Cell Line; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D017931:DNA Primers; D004669:Encephalitis Viruses, Tick-Borne / Q000502:physiology*; D006801:Humans; D009693:Nucleic Acid Hybridization; D020365:RNA Helicases / Q000235:genetics*; D011971:Receptors, Immunologic; D013382:Subtraction Technique
D017931:DNA Primers; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases