[Study on distribution of safflor yellow A in tissues of mice].
OBJECTIVE
To study the distributive character of safflor yellow A in mice.


METHODS
A RP-HPLC method for the determination of safflor yellow A in tissues was established and applied to determine safflor yellow A in biological samples.


RESULTS
After iv injection of Safflor yellow A in mice, the AUC of safflor yellow A was hightest in plasma, followed by kidney, liver, lung, heart, spleen. But it was not found in the brain.


CONCLUSIONS
The distribution of safflor yellow A in the body is abroad and the speed of its process is swift.
Liu
Yue-qing
YQ
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhou
Hai-tao
HT
Bi
Kai-shun
KS
D000818:Animals; D031187:Carthamus tinctorius / Q000737:chemistry; D002599:Chalcone / Q000031:analogs & derivatives* / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D035264:Flowers / Q000737:chemistry; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D011809:Quinones / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D011809:Quinones; C085278:hydroxysafflor yellow A; D002599:Chalcone