title: Expression of the RNA-binding protein CRD-BP in brain and non-small cell lung tumors.
abstract: The coding region determinant-binding protein (CRD-BP) is an RNA binding protein that recognizes c-myc and IGF-II leader 3 mRNAs as well as the oncofetal H19 RNA. CRD-BP exhibits an oncofetal pattern of expression and has been detected in the majority of colon (81%), breast (58.5%) and sarcoma (73%) tumors. The study of CRD-BP expression was extended in brain tumors and Non small cell lung (NSCL) carcinomas and 12/24 malignant, 2/5 benign neuroepithelial tumors and 4/15 of NSCL carcinomas were found positive. All normal matching tissues tested were found negative. The highest frequency (60%) of CRD-BP positive tumors was observed in meningiomas, either benign (11/18) or atypical (3/3). These findings confirm that CRD-BP expression is restricted in tumors; the frequency of its de novo expression may vary according to tumor type and appears to be an early event in the transformation process.
authors.affiliation: Department of Genetics, St Savas Hospital, Athens, Greece.
authors.forename: Panayotis
authors.initials: P
authors.lastname: Ioannidis
authors.forename: Christine
authors.initials: C
authors.lastname: Kottaridi
authors.forename: Euthimios
authors.initials: E
authors.lastname: Dimitriadis
authors.forename: Nelly
authors.initials: N
authors.lastname: Courtis
authors.forename: Louiza
authors.initials: L
authors.lastname: Mahaira
authors.forename: Maroulio
authors.initials: M
authors.lastname: Talieri
authors.forename: Andreas
authors.initials: A
authors.lastname: Giannopoulos
authors.forename: Kosmas
authors.initials: K
authors.lastname: Iliadis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Papaioannou
authors.forename: George
authors.initials: G
authors.lastname: Nasioulas
authors.forename: Theoni
authors.initials: T
authors.lastname: Trangas
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D006801:Humans; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D008577:Meningeal Neoplasms / Q000235:genetics / Q000378:metabolism; D008579:Meningioma / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; C406144:IGF2BP1 protein, human; D016601:RNA-Binding Proteins