title: A simple stereocontrolled synthesis of salinosporamide A.
abstract: A simple and effective stereocontrolled synthesis of salinosporamide A has been developed. This process, the first synthesis of salinosporamide A, is capable of providing the compound in substantial quantities for further biological studies. Salinosporamide A was of special interest as a synthetic target because of its potent in vitro cytotoxic activity against many tumor cell lines (IC(50) values of 10 nM or less).
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Leleti Rajender
authors.initials: LR
authors.lastname: Reddy
authors.forename: P
authors.initials: P
authors.lastname: Saravanan
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D011758:Pyrroles; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D007783:Lactones; D011758:Pyrroles; C475865:marizomib