[Nutrition assessment protein].
Nutrition status must be estimated during a patient's hospitalization. Body weight, hemoglobin or serum albumin are used to estimate nutrition status, but they can not reflect the present nutrition status. Recently, rapid turnover protein(RTP) has been proposed as a nutrition assessment protein, reflecting real-time nutrition status. The halves in the serum of retinal-binding protein(RBP) and transthyretin (TTR) are 0.5 and 2 days, respectively. Their physiological variations, such as intra-individual, diet, and athletics, are within 10%, so they are suitable for monitoring present nutrition status. Because they are negative acute-phase reactants, we have to measure CRP as a marker for the acute-phase reaction. Measuring RBP and TTR as monitoring markers reveals the accurate, real-time nutrition status of the patient. Providing accurate information for a patient's nutrition situation will support cure and early discharge, and reduce medical costs.
Takagi
Yasushi
Y
Department of Clinical Laboratories, Showa University Hospital, Shinagawa-ku, Tokyo 142-8666.
D000210:Acute-Phase Reaction / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002352:Carrier Proteins / Q000097:blood*; D017048:Health Care Costs; D006801:Humans; D007902:Length of Stay; D008991:Monitoring, Physiologic; D015596:Nutrition Assessment; D009752:Nutritional Status; D011228:Prealbumin / Q000032:analysis*; D012680:Sensitivity and Specificity
C020932:11-cis-retinal-binding protein; D015415:Biomarkers; D002352:Carrier Proteins; D011228:Prealbumin; D002097:C-Reactive Protein