[Endocrine tumors and growth factors].
A number of studies have revealed that various growth factors are produced in the malignant progression of endocrine tumors. Growth factors, classified based on their signal transduction pathways, exert the functions by binding to cell surface specific receptors, and promote the growth of tumors by autocrine and paracrine mechanisms. Growth factors such as VEGF and bFGF are also detected in endocrine tumors, and play an important role in the growth and metastasis of tumors via induction of angiogenesis. In the signal transduction pathways growth factors activate various kinases such as mitogen-activated protein kinase and/or phosphatidylinositol 3-kinase/Akt. Signaling cross-talk of growth factors, cytokines and steroid hormones has been observed in various endocrine tumors.
Yamaguchi
Yuri
Y
Saitama Cancer Center, Research Institute.
D002455:Cell Division; D016207:Cytokines / Q000502:physiology; D004701:Endocrine Gland Neoplasms / Q000378:metabolism* / Q000473:pathology*; D006133:Growth Substances / Q000096:biosynthesis* / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D020239:Receptor Cross-Talk / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D016207:Cytokines; D006133:Growth Substances; D020794:Receptor Protein-Tyrosine Kinases