Correlation between blood cAMP, cGMP levels and traumatic severity in the patients with acute trauma and its clinical significance.
In order to investigate the correlation between traumatic servity and blood cAMP and cGMP levels in the patients with acute trauma and its clinical significance, 120 cases of trauma were randomly selected and divided into 4 groups (n = 30 in each group): mildly traumatic group (ISS < or = 9), moderately traumatic group (ISS = 10-16), severely traumatic group (ISS = 17-25) and dangerously traumatic group (> 25). The cAMP and cGMP levels were assayed in sera, leucocytes and platelets respectively in 6 h and 24 h after trauma. The results showed that cAMP and cGMP levels were elevated significantly in sera and platelets (P < 0.05 or P < 0.01), meanwhile cGMP levels in leucocytes (P < 0.05). It was concluded that cAMP and cGMP might play an important role in traumatic stress, participate in the cellular signal transducation and promote the immune function of leucocytes and the coagulation founction of platelets. Serum cAMP and cGMP levels were upregulated correspondingly as ISS increased, and positively correlated to the traumatic severity.
Bai
Xiangjun
X
Department of Traumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Wang
Haiping
H
Li
Zhanfei
Z
Liu
Kaijun
K
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism; D000242:Cyclic AMP / Q000097:blood*; D006152:Cyclic GMP / Q000097:blood*; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014947:Wounds and Injuries / Q000097:blood*
D000242:Cyclic AMP; D006152:Cyclic GMP