title: Lack of effect of recombinant human growth hormone on the in vitro activities of antiretroviral drugs against human immunodeficiency virus type 1.
abstract: We studied the effects of recombinant human growth hormone (r-hGH) on human immunodeficiency virus type 1 replication by growing both wild-type and drug-resistant variants of virus in the presence of various concentrations of eight different antiretroviral drugs. r-hGH had no significant effect on either viral replication or the 50% inhibitory concentrations of these compounds.
authors.affiliation: McGill AIDS Center, Jewish General Hospital, Lady Davis Institute, 3755 Cote St. Catherine Rd., Montreal, Quebec H3T 1E2, Canada. mark.wainberg@mcgill.ca
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wainberg
authors.forename: Bluma G
authors.initials: BG
authors.lastname: Brenner
authors.forename: Eric
authors.initials: E
authors.lastname: Daar
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Gertner
authors.forename: Clement
authors.initials: C
authors.lastname: Olivier
authors.forename: Susan
authors.initials: S
authors.lastname: Kenley
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004347:Drug Interactions; D024882:Drug Resistance, Viral; D013006:Growth Hormone / Q000494:pharmacology*; D016655:HIV Core Protein p24 / Q000032:analysis / Q000096:biosynthesis; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D016655:HIV Core Protein p24; D013006:Growth Hormone