Effect of topiramate on mechanical allodynia in neuropathic pain model in rats.
Topiramate, unlike gabapentin, lamotrigine and tiagabine, resembles phenytoin and carbamazepine since it had been used as an antinociceptive drug in empirical treatment of neuropathic pain in humans, before its systemic and planned research was conducted in animal models of pain. Chronic administration of topiramate, at the dose of 50 mg/kg/day, significantly diminished the mechanical sensitivity and shortened the period of allodynia in the Seltzer mononeuropathy model in rats.
Wieczorkiewicz-Płaza
Anna
A
Department of Human Anatomy, Skubiszewski Medical University, Spokojna 1, PL 20-074 Lublin, Poland.
Płaza
Paweł
P
Maciejewski
Ryszard
R
Czuczwar
Mirosław
M
Przesmycki
Krzysztof
K
D000818:Animals; D004195:Disease Models, Animal; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D020426:Sciatic Neuropathy / Q000188:drug therapy*; D000077236:Topiramate
D000077236:Topiramate; D005632:Fructose