Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles.
This article reviews some important characteristics of microbubbles that give them therapeutic properties. It discusses the use of microbubbles and ultrasound for targeted delivery of adenovirus and nonviral vectors to myocytes and endothelial cells and for the dissolution of thrombus or potentiation of fibrinolytic agents for acutely thrombosed vessels. Potential applications, such as induction of angiogenesis, inhibition of neointimal hyperplasia, and in the setting of acute myocardial infarction and ischemic stroke,are discussed briefly.
Tsutsui
Jeane Mike
JM
Section of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, 600 South 42nd Street, Omaha, NE 68198, USA.
Grayburn
Paul A
PA
Xie
Feng
F
Porter
Thomas R
TR
D002317:Cardiovascular Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D045423:Microbubbles; D015912:Thrombolytic Therapy / Q000379:methods*; D014464:Ultrasonic Therapy
D002317:Cardiovascular Agents; D004337:Drug Carriers