Proteomic strategies and their application in studies of renal function.
Proteomics is a promising new tool for functional genomics. In addition to two-dimensional gel electrophoresis, other methods that are based on liquid chromatography and mass spectrometry are now available to study proteins. In this brief article, we review the strengths and limitations of the proteomic approaches currently available to the researcher, and we provide examples of how proteomics has been, and can in the future be, used to study the kidney.
Cutillas
Pedro
P
Ludwig Institute for Cancer Research and Department of Biochemistry, University College London, W1W 7BS, United Kingdom.
Burlingame
Alma
A
Unwin
Robert
R
D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods*; D006801:Humans; D007668:Kidney / Q000502:physiology*; D013058:Mass Spectrometry / Q000379:methods*; D040901:Proteomics / Q000379:methods*