Teratogenicity test of dimethoate containing insecticide formulation and Cd-sulphate in chicken embryos after administration as a single compound or in combination.
Cd-sulphate and a 38% dimethoate containing insecticide formulation (BI 58 EC) were used as test material in a teratogenicity test in chicken after administration as a single compounds or in combination. The incubated chicken eggs were directly exposed to the applied test materials with injection into the air-chamber in a volume of 0.1 ml/egg before the starting of incubation. Applied concentration of Cd-sulphate was 0.01% and the concentration of pesticide was 0.1%. Evaluation was done on day 19. In test of individual toxicity after injection on day 0 of incubation Cd-sulphate did not cause a significant reduction in body mass of embryos. The rate of embryonic mortality was 26%. After the administration of dimethoate containing insecticide formulation on day 0 of incubation no decrease occurred in embryonic body mass. The rate of embryonic mortality was 31%. The developmental anomalies observed in the different treatment groups occurred sporadically. The simultaneous administration of Cd-sulphate and the dimethoate containing insecticide formulation on day 0 of incubation resulted in expressed embryonic mortality. The rate of embryonic mortality was 93%. In summary, it can be established that the simultaneous administration of Cd-sulphate and the dimethoate containing insecticide formulation on day 0 in studies of chemical interaction exerted an adverse effect on embryonic mortality.
Budai
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Department of Hygiene, Institute of Plant Protection, Georgikon Faculty of Agriculture, University of Veszprém, P.O. Box 71, H-8361 Keszthely, Hungary.
Fejes
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Várnagy
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Somlyay
I M
IM
Szabó
Z K
ZK
D000014:Abnormalities, Drug-Induced / Q000662:veterinary; D000818:Animals; D019187:Cadmium Compounds / Q000633:toxicity*; D002642:Chick Embryo / Q000187:drug effects*; D004117:Dimethoate / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D007306:Insecticides / Q000633:toxicity*; D009026:Mortality; D013431:Sulfates / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*; D013997:Time Factors
D019187:Cadmium Compounds; D007306:Insecticides; D013431:Sulfates; D013723:Teratogens; C037123:cadmium sulfate; D004117:Dimethoate