Chemical constituents from the mangrove plant, Aegiceras corniculatum.
From the stems and twigs of the mangrove plant, Aegiceras corniculatum, seven new compounds, namely, 2-methoxy-3-nonylresorcinol (1), 5-O-ethylembelin (2), 2-O-acetyl-5-O-methylembelin (3), 3,7-dihydroxy-2,5-diundecylnaphthoquinone (4), 2,7-dihydroxy-8-methoxy-3,6-diundecyldibenzofuran-1,4-dione (5), 2,8-dihydroxy-7-methoxy-3,9-diundecyldibenzofuran-1,4-dione (6), and 10-hydroxy-4-O-methyl-2,11-diundecylgomphilactone (7), were isolated together with three known compounds, 5-O-methylembelin (8), 3-undecylresorcinol, and 2-dehydroxy-5-O-methylembelin. The structures of 1-7 were determined by spectroscopic methods. Compound 2 and 5-O-methylembelin showed in vitro cytotoxicity against the HL-60, Bel(7402), U937, and Hela cell lines.
Xu
Minjuan
M
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
Deng
Zhiwei
Z
Li
Min
M
Li
Jun
J
Fu
Hongzheng
H
Proksch
Peter
P
Lin
Wenhan
W
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D029623:Primulaceae / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; D001685:Biological Factors; D004365:Drugs, Chinese Herbal; D012118:Resorcinols