title: Fatty acid synthase expression and clinicopathological findings in endometrial cancer.
abstract: BACKGROUND
  Over-expression of fatty acid synthase (FAS), the enzyme involved in the anabolic conversion of dietary carbohydrates to fatty acid, has been reported in many human malignancies. This study investigated whether clinicopathological findings [histological grade, myometrial invasion, vessel permeation, lymphatic permeation, nodal metastasis, and Federation of International Gynecologic Obstetrics (FIGO) stage] and body fat distribution differ with the level of FAS expression in endometrial cancer.
  
  
  METHODS
  Subjects were 73 postmenopausal women (mean age, 62.2 +/- 7.4 years; range, 49-75 years) with endometrioid adenocarcinoma. Baseline characteristics included age, height, body weight (BW), body mass index (BMI), and years since menopause (YSM). Percentage of body fat and the trunk-leg fat mass ratio were measured by dual-energy X-ray absorptiometry. FAS expression was determined using immunohistochemical methods in formalin-fixed and paraffin-embedded cancer specimens. FAS expression was defined as none, low, and high.
  
  
  RESULTS
  Sixty-six (90.4%) cases showed positive FAS status. Sixty-nine percent of cases showed myometrial invasion > or =1/2, 50% of cases showed myometrial invasion <1/2, and 23% of cases without myometrial invasion demonstrated a positive FAS status. Lymphatic permeation, vessel permeation, nodal metastasis, and advancing FigO stage were associated with FAS status. The trunk-leg fat ratio and BMI in high and low FAS status groups were significantly greater than that in those not expressing FAS (p < 0.05). However, age, height, weight, YSM, and percentage of body fat did not differ with FAS status.
  
  
  CONCLUSIONS
  FAS expression in endometrial cancer is associated with cancer progression and upper body fat distribution.
authors.affiliation: Fom the Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan. tomy@m3.kufm.kagoshima-u.ac.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsuji
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yoshinaga
authors.forename: Shinichi
authors.initials: S
authors.lastname: Togami
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Douchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue; D000368:Aged; D000886:Anthropometry; D018269:Carcinoma, Endometrioid / Q000201:enzymology* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000201:enzymology* / Q000473:pathology; D064429:Fatty Acid Synthases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D064429:Fatty Acid Synthases