title: Effect of erythrocytes on the hepatic distribution kinetics of antipyrine.
abstract: The role of erythrocyte on the hepatic distribution kinetics of antipyrine was investigated in the in situ isolated perfused rat liver. Perfusion experiments were conducted using Krebs-bicarbonate buffer delivered via the portal vein in a single pass mode at a total flow rate of 15 ml/min. A bolus dose of antipyrine was administered in the presence and absence of erythrocytes. Almost identical moment analysis results (without erythrocytes mean transit time, MTT: 23 s; volume of distribution, VH: 0.57 ml/g liver and with erythrocytes, MTT: 24 s; VH: 0.60 ml/g liver) and superimposable unimodal effluent curves were obtained in the presence and absence of erythrocytes indicates that distribution kinetics of antipyrine within the liver is not affected by erythrocytes.
authors.affiliation: Hacettepe University, Faculty of Pharmacy, Ankara, Turkey.
authors.forename: Selma
authors.initials: S
authors.lastname: Sahin
authors.forename: Malcolm
authors.initials: M
authors.lastname: Rowland
mesh_terms: D000818:Animals; D000983:Antipyrine / Q000493:pharmacokinetics*; D004912:Erythrocytes / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution / Q000502:physiology
chemical_list: D000983:Antipyrine