Lack of association between the TNF alpha G -308 A promoter polymorphism and periodontal disease.
BACKGROUND
Immunorelevant gene polymorphisms might influence the susceptibility for periodontal disease. The present study assessed the frequency of a promoter polymorphism (-308G-to-A) of the tumour necrosis factor (TNF)alpha gene in patients with periodontitis and controls.


METHODS
Eighty-one patients with generalized chronic periodontitis and 80 healthy controls were genotyped for the -308 polymorphism of the TNF alpha gene by PCR amplification and subsequent restriction fragment length polymorphism analysis. The diagnosis of chronic periodontitis was made for each subject on basis of standardized clinical and radiographic criteria.


RESULTS
In patients with peridontitis and controls, the frequency of the TNF alpha-308 A allele was comparable (19.1% [31/162] versus 13.8% [22/160]; p=0.193).


CONCLUSIONS
The present study revealed no association between the -308 TNF alpha gene polymorphism and periodontal disease.
Folwaczny
Matthias
M
Poliklinik für Zahnerhaltung und Parodontologie, Ludwig-Maximilians Universität, Munich, Germany. mfolwa@dent.uni-muenchen.de
Glas
Jürgen
J
Török
Helga-Paula
HP
Mende
Monika
M
Folwaczny
Christian
C
D000225:Adenine; D000328:Adult; D000368:Aged; D000483:Alleles; D002908:Chronic Disease; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006147:Guanine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000235:genetics / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D006147:Guanine; D000225:Adenine