Selagoline, a new alkaloid from Huperzia selago.
A new natural product, named selagoline, and two known alkaloids, huperzine A and serratidine, were isolated from Huperzia selago (Lycopodiaceae) collected in Iceland. Their structures were determined using 600 and 800MHz one- and two-dimensional NMR methods supported by Fourier-transform mass spectrometry. Possible role of selagoline as a precursor of 5,15-oxidolycopodane, a component of the classical alkaloids L28 and L31, is discussed.
Staerk
Dan
D
Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark.
Larsen
Jesper
J
Larsen
Line A
LA
Olafsdottir
Elin S
ES
Witt
Matthias
M
Jaroszewski
Jerzy W
JW
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D032501:Huperzia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D017550:Spectroscopy, Fourier Transform Infrared
D000470:Alkaloids; D002800:Cholinesterase Inhibitors; D012717:Sesquiterpenes; C486661:selagoline; C458904:serratidine; C050426:huperzine A