title: [Prognostic significance of lymphatic micrometastasis of esophageal adenocarcinoma].
abstract: The aim of the study was to test the hypothesis that a subgroup of patients considered N0 at standard single-section pathological examination may have occult lymph-node metastases (micrometastases) associated with a poor prognosis. Fifty-nine patients with oesophageal adenocarcinoma undergoing resection were studied by standard histological examinations, serial sections and immunohistochemistry, and their long-term prognoses were compared. Eight (26%) out of 31 patients previously staged as pN0 at standard histological examination were staged as pN1 or Pn2 by serial sections and/or immunohistochemistry and had a prognosis which was significantly worse than that of true pN0 patients (5-year survival: 38% vs 76%, respectively; P < 0.05) and similar to that of pN1 patients. More than a quarter of those patients classified as pN0 at standard histological examination may have occult lymph node metastases at serial sections and/or immunohistochemistry and have a prognosis similar to that of pN1 patients.
authors.affiliation: Dipartimento di Scienze Medico-Chirurgiche, Divisione di Chirurgia Generale Istituto Policlinico San Donato, Università di Milano.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bonavina
authors.forename: Raffaello
authors.initials: R
authors.lastname: Incarbone
authors.forename: Valeria
authors.initials: V
authors.lastname: Midolo
authors.forename: Davide
authors.initials: D
authors.lastname: Bona
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrero
authors.forename: Chiara
authors.initials: C
authors.lastname: Dall'Asta
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D000328:Adult; D000368:Aged; D004938:Esophageal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis