Novel polymer-synthesized ceramic composite-based system for bone repair: an in vitro evaluation.
The emergence of synthetic bone repair scaffolds has been necessitated by the limitations of both autografts and allografts. Several candidate materials are available including degradable polymers and ceramics. However, these materials possess their own limitations that at least in part may be overcome by combining the two materials into a composite. Toward that end, a novel approach to forming a polymer/ceramic composite has been developed that combines degradable poly(lactide-co-glycolide) microspheres and a poorly crystalline calcium phosphate that is synthesized within the microspheres, which are then fused together to form a porous three-dimensional scaffold for bone repair. The design, fabrication, and characterization of the composite microspheres, the calcium phosphate formed within these microspheres, and the formation of scaffolds were studied. The calcium phosphate formed was analyzed by x-ray diffraction, Fourier transform infrared spectroscopy, and energy dispersive spectroscopy, and was shown to be similar to native bone in both composition and crystallinity by controlling certain processing parameters such as mixing time, solution pH, and mixing temperature. Scaffolds with porous interconnected structures and mechanical properties in the range of trabecular bone were fabricated via precise control of polymer/ceramic ratios within the microspheres and scaffold heating times. This composite scaffold represents a new and important vehicle for bone-tissue engineering.
Khan
Yusuf M
YM
School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA 19104, USA.
Katti
Dhirendra S
DS
Laurencin
Cato T
CT
D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D017550:Spectroscopy, Fourier Transform Infrared
D018786:Bone Substitutes; D002130:Calcium Phosphates; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C020243:calcium phosphate