[Different responses of DD/He and CC57BR/Mv mice to fasting].
Reaction to fasting of 2 mice strains differing in their sensitivity to spontaneous and induced hepatocarcinogenesis, has been investigated. It was shown that mice of both strains displayed similar stress reaction after 3-day fasting manifested in increase in blood corticosterone level; and decrease in testosterone level. At the same time, both strains demonstrated opposite changes at tissue- and enzyme levels in the liver. It was shown that DD/He mice, highly sensitive to induction of liver tumors, were characterized by significant increase in tyrosine aminotransferase (TAT) activity and reduction of lipid droplets in hepatocytes. CC57BR/Mv mice, demonstrating high frequency of spontaneous hepatomas and insensitive to induction of such tumors, were characterized by a decrease in the TAT activity and fatty infiltration of the liver.
Baginskaia
N V
NV
Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Branch, 10 Pr. Lavrentyeva, Novosibirsk 630090, Russia.
Vasil'eva
E D
ED
Il'nitskaia
S I
SI
Kaledin
V I
VI
D000818:Animals; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D005215:Fasting; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000201:enzymology / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D008297:Male; D051379:Mice; D013045:Species Specificity; D013739:Testosterone / Q000097:blood; D014444:Tyrosine Transaminase / Q000378:metabolism
D008055:Lipids; D013739:Testosterone; D014444:Tyrosine Transaminase; D003345:Corticosterone