title: Parasympathetic cardiac nerve stimulation with implanted coronary sinus lead.
abstract: A patient with drug-refractory paroxysmal atrial fibrillation associated with rapid ventricular rate underwent biatrial pacemaker implantation. During elective replacement of the pacemaker, a significant voltage- and frequency-dependent decrease in ventricular rate was achieved by high-frequency electrical stimulation (17 Hz) of parasympathetic cardiac nerves innervating the AV node with the implanted bipolar coronary sinus electrode. The negative dromotropic effect of parasympathetic stimulation was eliminated by intravenous administration of 1-mg atropine.
authors.affiliation: Cardiovascular Centre, Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary.
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Vágó
authors.forename: Attila
authors.initials: A
authors.lastname: Róka
authors.forename: György
authors.initials: G
authors.lastname: Acsády
authors.forename: Béla
authors.initials: B
authors.lastname: Merkely
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage; D001285:Atropine / Q000008:administration & dosage; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D012849:Sinoatrial Node / Q000187:drug effects / Q000294:innervation* / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D001285:Atropine