title: Developmental precursors of psychosis.
abstract: Subtle developmental (motor, emotional, cognitive, and behavioral) abnormalities are often present in apparently healthy individuals who later develop psychosis, suggesting that some aspects of causation are established before overt psychosis. These impairments may restrict information processing and social achievements years before manifesting psychosis. The main known risk factors in the development of schizophrenic psychosis are genetic factors, pregnancy and delivery complications, slow neuromotor development, and deviant cognitive and academic performance. However, their effect size and predictive power are small. Developmental precursors are not necessarily specific to schizophrenia, but also common to other psychotic disorders. No powerful risk factor, premorbid sign, or risk indicator has been identified that is useful for prediction of psychoses in the general population.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, University of Oulu, Oulu University Central Hospital, PO Box 5000, FIN-90014 Oulu, Finland. matti.isohanni@oulu.fi
authors.forename: Matti
authors.initials: M
authors.lastname: Isohanni
authors.forename: Irene
authors.initials: I
authors.lastname: Isohanni
authors.forename: Hannu
authors.initials: H
authors.lastname: Koponen
authors.forename: Johanna
authors.initials: J
authors.lastname: Koskinen
authors.forename: Pekka
authors.initials: P
authors.lastname: Laine
authors.forename: Erika
authors.initials: E
authors.lastname: Lauronen
authors.forename: Jouko
authors.initials: J
authors.lastname: Miettunen
authors.forename: Pirjo
authors.initials: P
authors.lastname: Mäki
authors.forename: Kaisa
authors.initials: K
authors.lastname: Riala
authors.forename: Sami
authors.initials: S
authors.lastname: Räsänen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Saari
authors.forename: Pekka
authors.initials: P
authors.lastname: Tienari
authors.forename: Juha
authors.initials: J
authors.lastname: Veijola
authors.forename: Graham
authors.initials: G
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D041923:Adolescent Development; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002657:Child Development; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications; D003405:Creativity; D036861:Delivery, Obstetric / Q000009:adverse effects; D004522:Educational Status; D005190:Family / Q000523:psychology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008055:Lipids / Q000097:blood; D009048:Motor Skills; D015985:Precipitating Factors; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011297:Prenatal Exposure Delayed Effects; D011618:Psychotic Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D012307:Risk Factors; D012559:Schizophrenia / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012737:Sex Factors
chemical_list: D001786:Blood Glucose; D008055:Lipids