3,3(')-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group.
3,3(')- Oxybis(dimethoxytrityl chloride) (O-DMTCl) was synthesized as a novel, acid-labile bifunctional protecting reagent. The reactions of O-DMTCl with base-protected ribonucleosides afforded unexpectedly 2('),5(')-cyclic protected ribonucleosides in addition to the expected 3('),5(')-cyclic protected ribonucleosides in good yields.
Oka
Natsuhisa
N
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
Sanghvi
Yogesh S
YS
Theodorakis
Emmanuel A
EA
D002712:Chlorides / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008737:Methyl Chloride / Q000138:chemical synthesis; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis; D014320:Triphenylmethyl Compounds / Q000138:chemical synthesis*
D002712:Chlorides; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D012263:Ribonucleosides; D014320:Triphenylmethyl Compounds; D008737:Methyl Chloride