title: Prevalence of Chlamydia pneumoniae infection in squamous cell carcinoma of the head and neck.
abstract: On the basis of epidemiological data, an association between Chlamydia pneumoniae (Cp) infection and head and neck cancer might be suggested. The aim of the present study was to detect Cp-DNA within tumour tissue specimens by a two-step polymerase chain reaction. Investigation was planned on the Fleming's procedure for early termination when initial results were extreme. So, after ten consecutive patients, only one tumour contained Cp-DNA. Hence the prevalence could be regarded as inferior to 60% (2a=b=0.08), the threshold under which a direct role of Cp in head and neck cancer development does not seem to be likely.
authors.affiliation: Institut Jean-Godinot, Service de médecine, 1 Av du general Koenig BP 171, 51056 Reims cedex, France.
authors.forename: Karinne
authors.initials: K
authors.lastname: Moutel
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Merol
authors.forename: Alain
authors.initials: A
authors.lastname: Prevost
authors.forename: Francois
authors.initials: F
authors.lastname: Eb
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Lefebvre
authors.forename: Paul
authors.initials: P
authors.lastname: Coninx
authors.forename: Francoise
authors.initials: F
authors.lastname: Liautaud-Roger
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000382:microbiology*; D023521:Chlamydophila Infections / Q000150:complications* / Q000453:epidemiology; D016993:Chlamydophila pneumoniae / Q000235:genetics*; D004269:DNA, Bacterial / Q000032:analysis; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence
chemical_list: D004269:DNA, Bacterial