NMR spectroscopy and pediatric brain tumors.
Proton nuclear magnetic resonance spectroscopy ((1)H-NMRS) is a noninvasive in vivo technique that utilizes conventional MR imaging hardware to obtain biochemical information from a discrete volume of tissue after suppression of the water signal. MR spectroscopy coupled with conventional MR imaging allows correlation of structural changes with biochemical processes in tissues by measuring specific metabolites present in brain tissue. NMRS is commonly used in the evaluation of patients with brain tumors. This article reviews the basic principles of spectroscopy and its use in evaluating pediatric patients with brain tumors.
Warren
Katherine E
KE
Neuro-Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-8200, USA. warrenk@mail.nih.gov
D000367:Age Factors; D001932:Brain Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000378:metabolism; D002648:Child; D006801:Humans; D009682:Magnetic Resonance Spectroscopy