[Anti-aging action of the total lactones of ginkgo on aging mice].
OBJECTIVE
To investigate the effects of total lactones of ginkgo on aging by using D-galactose induced aging mice and natural aging mice.


METHODS
By using D-galactose induced aging mice, to detect the LF content in heart and liver, the Hyp content in liver, the MAO, GSH-Px activities and the NO content in cerebrum. The apoptosis of cerebral cell was determined by terminal deoxy-nucleotidyl transforase-mediated dUTP-digoxigenin nick end-labeling (Tunel) in natural aging mice.


RESULTS
TLG was shown to increase the GSH-Px activities, reduce the NO content and decrease the MAO activity in cerebrum. Meanwhile, TLG was found to reduce the LF content in liver and heart and raise the Hyp content in liver. TLG was shown to inhibit apoptosis of cerebral cell and decrease the number of apoptotic cells in the brain.


CONCLUSIONS
TLG possesses effect on antiaging via attenuating lipid peroxidation and NO and apoptosis of cerebral cells.
Dong
Liu-yi
LY
Department of Pharmacology, Anhui Medical University, Hefei 230032, China. Dongly061@hotmail.com
Fan
Li
L
Li
Gui-fang
GF
Guo
Yan
Y
Pan
Jian
J
Chen
Zhi-wu
ZW
D000375:Aging / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005260:Female; D005690:Galactose; D020441:Ginkgo biloba / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000378:metabolism; D006909:Hydroxyproline / Q000378:metabolism; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D008062:Lipofuscin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D013687:Telencephalon / Q000201:enzymology / Q000378:metabolism
D007783:Lactones; D008062:Lipofuscin; D009569:Nitric Oxide; D005979:Glutathione Peroxidase; D008995:Monoamine Oxidase; D006909:Hydroxyproline; D005690:Galactose