Prevalence of Chlamydia pneumoniae infection in squamous cell carcinoma of the head and neck.
On the basis of epidemiological data, an association between Chlamydia pneumoniae (Cp) infection and head and neck cancer might be suggested. The aim of the present study was to detect Cp-DNA within tumour tissue specimens by a two-step polymerase chain reaction. Investigation was planned on the Fleming's procedure for early termination when initial results were extreme. So, after ten consecutive patients, only one tumour contained Cp-DNA. Hence the prevalence could be regarded as inferior to 60% (2a=b=0.08), the threshold under which a direct role of Cp in head and neck cancer development does not seem to be likely.
Moutel
Karinne
K
Institut Jean-Godinot, Service de médecine, 1 Av du general Koenig BP 171, 51056 Reims cedex, France.
Merol
Jean-Claude
JC
Prevost
Alain
A
Eb
Francois
F
Lefebvre
Jean-Francois
JF
Coninx
Paul
P
Liautaud-Roger
Francoise
F
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000382:microbiology*; D023521:Chlamydophila Infections / Q000150:complications* / Q000453:epidemiology; D016993:Chlamydophila pneumoniae / Q000235:genetics*; D004269:DNA, Bacterial / Q000032:analysis; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000453:epidemiology; D015995:Prevalence
D004269:DNA, Bacterial