title: Chromosomal aberrations in arsenic-exposed human populations: a review with special reference to a comprehensive study in West Bengal, India.
abstract: For centuries arsenic has played an important role in science, technology, and medicine. Arsenic for its environmental pervasiveness has gained unexpected entrance to the human body through food, water and air, thereby posing a great threat to public health due to its toxic effect and carcinogenicity. Thus, in modern scenario arsenic is synonymous with "toxic" and is documented as a paradoxical human carcinogen, although its mechanism of induction of neoplasia remains elusive. To assess the risk from environmental and occupational exposure of arsenic, in vivo cytogenetic assays have been conducted in arseniasis-endemic areas of the world using chromosomal aberrations (CA) and sister chromatid exchanges (SCE) as biomarkers in peripheral blood lymphocytes. The primary aim of this report is to critically review and update the existing in vivo cytogenetic studies performed on arsenic-exposed populations around the world and compare the results on CA and SCE from our own study, conducted in arsenic-endemic villages of North 24 Parganas (district) of West Bengal, India from 1999 to 2003. Based on a structured questionnaire, 165 symptomatic (having arsenic induced skin lesions) subjects were selected as the exposed cases consuming water having a mean arsenic content of 214.96 microg/l. For comparison 155 age-sex matched control subjects from an unaffected district (Midnapur) of West Bengal were recruited. Similar to other arsenic exposed populations our population also showed a significant difference (P < 0.01) in the frequencies of CA and SCE between the cases and control group. Presence of substantial chromosome damage in lymphocytes in the exposed population predicts an increased future carcinogenic risk by this metalloid.
authors.affiliation: Division of Human Genetics and Genomics, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.
authors.forename: J
authors.initials: J
authors.lastname: Mahata
authors.forename: M
authors.initials: M
authors.lastname: Chaki
authors.forename: P
authors.initials: P
authors.lastname: Ghosh
authors.forename: L K
authors.initials: LK
authors.lastname: Das
authors.forename: K
authors.initials: K
authors.lastname: Baidya
authors.forename: K
authors.initials: K
authors.lastname: Ray
authors.forename: A T
authors.initials: AT
authors.lastname: Natarajan
authors.forename: A K
authors.initials: AK
authors.lastname: Giri
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D001151:Arsenic / Q000009:adverse effects* / Q000032:analysis; D002648:Child; D002869:Chromosome Aberrations; D019457:Chromosome Breakage; D002877:Chromosomes, Human / Q000235:genetics* / Q000648:ultrastructure; D004781:Environmental Exposure; D015340:Epidemiologic Research Design; D005260:Female; D014943:Global Health; D006801:Humans; D007194:India / Q000453:epidemiology; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008452:Maximum Allowable Concentration; D015162:Micronucleus Tests; D008875:Middle Aged; D009152:Mutagenicity Tests; D009153:Mutagens / Q000009:adverse effects; D016273:Occupational Exposure; D012854:Sister Chromatid Exchange / Q000187:drug effects; D012871:Skin Diseases / Q000139:chemically induced / Q000453:epidemiology; D014874:Water Pollutants, Chemical / Q000009:adverse effects; D014881:Water Supply
chemical_list: D000395:Air Pollutants, Occupational; D009153:Mutagens; D014874:Water Pollutants, Chemical; D001151:Arsenic