title: Treatment delay and pathology results in women with low-grade squamous intraepithelial lesions. A preliminary study.
abstract: Regression rate of CIN 1 (LSIL) can reach 85%. The purpose of this study was to investigate retrospectively pathology specimens in CIN 1 cases who delayed treatment > 2 years despite the persistence of the lesion. One hundred and fifteen women diagnosed with CIN 1 were separated in two groups as follows: A) 92 women who underwent ablative treatment within three months after the completion of two years; B) 23 women who delayed ablative treatment for a mean interval of > 1 year after the completion of two years. Exclusion criteria were normal cytology and colposcopy results within the completion of two years. The chi-square, t-test and Kaplan-Meier method were used for analysis. Persistence of LSIL lesions was observed in 84% of the first group and persistence or regression of the lesion in 78% of the second one. The study suggests the possibility of prolongation of the observation period after LSIL diagnosis. Prospective studies with close follow-up are needed for final conclusions.
authors.affiliation: Department of Obstetrics and Gynecology of the Technological Educational Institution of Athens, Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Iatrakis
authors.forename: G
authors.initials: G
authors.lastname: Kourounis
authors.forename: N
authors.initials: N
authors.lastname: Georgopoulos
authors.forename: J
authors.initials: J
authors.lastname: Karachotzitis
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008499:Medical Records; D018307:Neoplasms, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis; D016312:Treatment Refusal; D002578:Uterine Cervical Dysplasia / Q000401:mortality* / Q000473:pathology / Q000601:surgery