title: Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen.
abstract: Cryptococcus neoformans releases capsular polysaccharide in the supernatant of liquid cultures and in tissues. Significantly less glucuronoxylomannan (GXM) was released by C. neoformans in the presence of capsule-binding monoclonal antibody (MAb). MAb-mediated inhibition of GXM release may be another mechanism by which humoral immunity can mediate protection against this pathogen.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Martinez
authors.forename: Dariush
authors.initials: D
authors.lastname: Moussai
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
mesh_terms: D000908:Antibodies, Fungal / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000946:Antigens, Fungal / Q000276:immunology* / Q000378:metabolism*; D003455:Cryptococcus neoformans / Q000254:growth & development* / Q000276:immunology / Q000378:metabolism; D003470:Culture Media; D006801:Humans; D011134:Polysaccharides / Q000276:immunology* / Q000378:metabolism
chemical_list: D000908:Antibodies, Fungal; D000911:Antibodies, Monoclonal; D000946:Antigens, Fungal; D003470:Culture Media; D011134:Polysaccharides; C027478:glucuronoxylomannan