title: Does any lower gastrointestinal bleeding in patients suffering from hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu) necessitate a full colonic visualization?
abstract: BACKGROUND
  Hereditary hemorrhagic telangiectasia (HHT) (the Osler-Weber-Rendu syndrome) is a rare autosomal dominant disease characterized by telangiectasias and arteriovenous malformations of the upper and lower respiratory tract, gastrointestinal tract, skin and central nervous system. Several previous reports have documented the appearance of a concomitant neoplasm in patients with this syndrome.
  
  
  OBJECTIVE
  To study the occurrence and the clinical characterization of colonic neoplasm in patients with HHT.
  
  
  METHODS
  We retrospectively reviewed the computerized database of the Hadassah University Hospitals (Jerusalem, Israel) for all patients with the diagnosis of HHT between January 1st, 1980 and July 30th, 2002. Cases of neoplasm were documented by review of medical charts and pathology reports.
  
  
  RESULTS
  Six of the 24 patients developed malignancy. Three of the cases had extra colonic malignancy (melanoma in two patients and adenocarcinoma of urinary bladder in one patient) and three patients had adenocarcinoma of the colon. An additional three patients developed multiple colonic polyps (one patient had melanoma and one patient had adenocarcinoma of urinary bladder).
  
  
  CONCLUSIONS
  HHT may be associated with the development of colonic adenocarcinoma and polyps. Therefore, in patients with HHT who present with new-onset anemia or gastrointestinal bleeding a lower gastrointestinal tract evaluation should be performed, even if their blood loss is suspected to be a manifestation of gastrointestinal HHT.
authors.affiliation: Department of Medicine, Mount Scopus Hadassah Hospital, P.O. Box 24035, Jerusalem 91240, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
authors.forename: Shaden
authors.initials: S
authors.lastname: Salameh-Giryes
authors.forename: Zvi
authors.initials: Z
authors.lastname: Ackerman
authors.forename: Neta
authors.initials: N
authors.lastname: Goldschmidt
authors.forename: Aviram
authors.initials: A
authors.lastname: Nissan
authors.forename: Tova
authors.initials: T
authors.lastname: Chajek-Shaul
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000209:etiology*; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000209:etiology*; D003111:Colonic Polyps / Q000209:etiology*; D003113:Colonoscopy; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications*