[Proinflammatory cytokine interleukin-17 and its role in pathogenesis of rheumatoid arthritis].
This is a review concerning the role of interleukin-17, a proinflammatory cytokine, produced by activated memory CD4+ T cells, in pathogenesis of rheumatoid arthritis. As interleukin-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. Interleukin-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
Leonaviciene
Laima
L
Institute of Experimental and Clinical Medicine, Vilnius University, Zygimantu 9, 2600 Vilnius, Lithuania. laima.leonaviciene@ekmi.vu.lt
Bradūnaite
Rūta
R
Astrauskas
Vytautas
V
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D020381:Interleukin-17 / Q000032:analysis / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000473:pathology; D011509:Proteoglycans / Q000378:metabolism; D013582:Synovial Fluid / Q000737:chemistry; D013583:Synovial Membrane / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D007375:Interleukin-1; D020381:Interleukin-17; D011509:Proteoglycans; D014409:Tumor Necrosis Factor-alpha; D003094:Collagen