Spontaneous pneumothorax developed in patients with bronchiolitis obliterans after unrelated hematopoietic stem cell transplantation: case report and review of the literature.
Spontaneous pneumothorax following unrelated hematopoietic stem cell transplantation developed in our 2 patients with bronchiolitis obliterans. Bronchiolitis obliterans is a form of obstructive airway disease and is considered a manifestation of chronic graft-versus-host disease (GVHD). Both of the patients were the recipients of marrow from HLA-matched unrelated donors after a preparative regimen with total body irradiation. Chronic GVHD after transplantation is a common feature in these cases. In contrast to other patients with pneumothorax described in the literature, our patients did not develop bullae. We describe a pneumothorax secondary to bronchiolitis obliterans that complicated the posttransplantation course.
Shin
Ho-Jin
HJ
Department of Internal Medicine, College of Medicine, Pusan National University, Busan, Korea.
Park
Chi Young
CY
Park
Yun Hee
YH
Kim
Yoo Jin
YJ
Min
Chang-Ki
CK
Lee
Seok
S
Kim
Dong-Wook
DW
Lee
Jong Wook
JW
Min
Woo Sung
WS
Kim
Chun Choo
CC
D000328:Adult; D001989:Bronchiolitis Obliterans / Q000150:complications* / Q000209:etiology; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011030:Pneumothorax / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation