title: Recurrent pregnancy loss and its relation to FV Leiden, FII G20210A and polymorphisms of plasminogen activator and plasminogen activator inhibitor.
abstract: Thrombophilic disorders and hypofibrinolysis were demonstrated to be risk factors in a majority of women with recurrent pregnancy loss (RPL) and infertility. We investigated the association of FV G1691A mutation, F II G20210A gene polymorphism (PM), 4G/5G PAI-1 and Alu I/D tPA PM in 32 women with infertility and 49 women with at least 2 unexplained early abortions. FV Leiden mutation was significantly more common in women with RPL (10%, p = 0.02) and infertility (19%, p = 0.0005) compared with controls (2%). PAI-1 4G PM and t-PA Alu I PM, alone or in combination, were not associated with RPL or infertility. 9/49 women with RPL showed coagulation disorders with heterozygous FV Leiden mutation (5), FXII (1), protein C (1) or protein S (2) deficiency. However, due to the small number of patients studied, no definite conclusion can be drawn.
authors.affiliation: Department of Transfusion Medicine, University of Göttingen, Göttingen, Germany. cwolf@med.uni-goettingen.de
authors.forename: Cornelia E
authors.initials: CE
authors.lastname: Wolf
authors.forename: Hannelore
authors.initials: H
authors.lastname: Haubelt
authors.forename: Hans Ulrich
authors.initials: HU
authors.lastname: Pauer
authors.forename: Bernd
authors.initials: B
authors.lastname: Hinney
authors.forename: Claudette
authors.initials: C
authors.lastname: Krome-Cesar
authors.forename: Tobias J
authors.initials: TJ
authors.lastname: Legler
authors.forename: Peter
authors.initials: P
authors.lastname: Hellstern
authors.forename: Günter
authors.initials: G
authors.lastname: Emons
authors.forename: Barbara
authors.initials: B
authors.lastname: Zoll
authors.forename: Michael
authors.initials: M
authors.lastname: Köhler
mesh_terms: D000026:Abortion, Habitual / Q000097:blood* / Q000209:etiology / Q000235:genetics; D000328:Adult; D001779:Blood Coagulation Factors / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005165:Factor V; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D010960:Plasminogen Activators / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000150:complications
chemical_list: D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D010960:Plasminogen Activators