[Interferonogenic activity of immobilized ribopolynucleotides in vitro].
In vitro experiments the authors have studied a property of yeast RNA--tilorone hydrochloride complex covalently linked to spheron to induce the synthesis of interferons type I (alpha- and beta-interferons) in the culture of peripheral mononuclear human cells. Such a complex is shown to possess a marked interferonogenic activity. The data obtained appear to be a proof of the interferon induction to be realised by a mechanism needing at the first stage the contact between the inducer and the cell surface without its penetration into the cell.
Zholobak
N M
NM
Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Mandzhos
A P
AP
Verevka
S V
SV
Povodzinskiĭ
V M
VM
Karpov
A V
AV
D005656:Fungal Proteins / Q000096:biosynthesis*; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D011070:Poly I-C / Q000494:pharmacology; D012330:RNA, Double-Stranded / Q000494:pharmacology*; D012331:RNA, Fungal / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism*; D013994:Tilorone / Q000494:pharmacology
D005656:Fungal Proteins; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012331:RNA, Fungal; C076741:ridostin; D007372:Interferons; D013994:Tilorone; D011070:Poly I-C