Potential hypotensive agents: synthesis and hypotensive activity of oxime ethers derived from 1-naphthoxepines and related compounds.
The synthesis and pharmacological evaluation of substituted oximino-ethers 1 and 2 of naphth[1,2-b]- and naphth[2,1-b]-oxepin-5-ones (4 and 8) were carried out. The hypotensive activity of oximino-ethers 1 and 2 was evaluated on anaesthetized cats. The results indicated that 1c caused a fall of 80 mm/Hg for >100' at a dose of 5mg/kg iv in anaesthetized cats.
Tandon
Vishnu K
VK
Department of Chemistry, University of Lucknow, Lucknow-226007, India. vishnutandon@rediffmail.com
Kumar
Manoj
M
Awasthi
Anoop K
AK
Saxena
Hari O
HO
Goswamy
Gajendra K
GK
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002415:Cats; D010082:Oxepins / Q000138:chemical synthesis* / Q000494:pharmacology; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology
D000959:Antihypertensive Agents; D010082:Oxepins; D010091:Oximes