[Effects on neuronal ultrastructure and nervous system of monkey after selective cerebral profound hypothermia and blood flow occlusion].
OBJECTIVE
To study the effects of deep hypothermia on the neuronal ultrastructure and nervous system of monkey after selective cerebral profound hypothermia and blood flow occlusion.


METHODS
Brain-local extracorporeal circulation was established by right internal carotid artery deep hypothermic perfusion and homolateral external jugular vein backflow, brain blood flow was recovered from circulatory arrest 60 - 80 minutes late and monkey came back naturally.


RESULTS
In all 7 monkeys, 5 were succeeded in being build up the models except for 2 because of technic problems, and 4 of them lived up for ever. The function of nervous system grade, essential organ and neuronal ultrastructure were normal.


CONCLUSIONS
Selective cerebral profound hypothermia can increase the ability of brain to endure hypovolemia and hypoxidosis and prolong the time of blood flow occlusion.
Xu
Wei
W
Department of Neurosurgery, the Second Affiliated Hospital of Kunming Medical College, Kunming 650101, China.
Jiang
Ji-yao
JY
Yang
Peng-fan
PF
Gao
Yong-jun
YJ
Fang
Shao-long
SL
Fu
Deng-li
DL
D000818:Animals; D002545:Brain Ischemia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D005112:Extracorporeal Circulation / Q000009:adverse effects; D005260:Female; D000882:Haplorhini; D007036:Hypothermia, Induced; D008297:Male; D013997:Time Factors