title: Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists.
abstract: A series of substituted spirobenzazepines was prepared and evaluated as V(1a) and V(2) dual vasopressin receptor antagonists. Compounds 7p and 7q have been shown to be not only potent inhibitors of vasopressin receptors, but also have exhibited an excellent overall pharmaceutical suitability profile.
authors.affiliation: Endocrine Therapeutics and Metabolic Disorders, Johnson and Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Bldg: PCC, Room: PC110, Raritan, NJ 08869, USA.
authors.forename: Min Amy
authors.initials: MA
authors.lastname: Xiang
authors.forename: Robert H
authors.initials: RH
authors.lastname: Chen
authors.forename: Keith T
authors.initials: KT
authors.lastname: Demarest
authors.forename: Joseph
authors.initials: J
authors.lastname: Gunnet
authors.forename: Richard
authors.initials: R
authors.lastname: Look
authors.forename: William
authors.initials: W
authors.lastname: Hageman
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
authors.forename: Donald W
authors.initials: DW
authors.lastname: Combs
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rybczynski
authors.forename: Mona
authors.initials: M
authors.lastname: Patel
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D051381:Rats; D017483:Receptors, Vasopressin / Q000378:metabolism
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D017483:Receptors, Vasopressin