title: [A hairy B cell lymphoproliferative disorder resembling hairy cell leukemia].
abstract: This case report describes a hairy B cell lymphoproliferative disorder (HBLD) with clinical and hematological features resembling hairy cell leukemia. The patient was a 29-year-old female who demonstrated atypical lymphocytes in her peripheral blood. Physical examination demonstrated splenomegaly, but there were no palpable superficial lymph nodes. Hematological examination showed a leukocyte count of 10.6 x 10(3)/mm3 with 41% atypical lymphocytes. Bone marrow examination showed a normal cellular and an atypical lymphocyte count of 42%. The atypical lymphocytes had microvilli and prominent membranous ruffles on their surfaces. Atypical lymphocytes expressed CD5- CD10- CD11c+ CD19+ CD20+ CD23- CD25- on the surface of the cells on examination by with a fluorescence activated cell sorter. Although these findings were similar to hairy cell leukemia, Japanese variant, the surface marker of the kappa chain and lambda chain was unbiased and studies of immunoglobulin gene rearrangements and expression showed polyclonal proliferation of B cells. Therefore, we diagnosed this patient as having HBLD. Because she did not demonstrate anemia or thrombocytopenia, she is not currently receiving medication. To date, the atypical lymphocyte count has not changed.
authors.affiliation: Internal Medicine, Kohka Public Hospital.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yagi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Sakabe
authors.forename: Rie
authors.initials: R
authors.lastname: Kakinoki
authors.forename: Kouhei
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Inoue
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Machii
mesh_terms: D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000473:pathology*