Sonochemistry of antitumor quinones in argon-saturated aqueous solutions: enhanced ferricytochrome c reduction.
Sonolysis of argon-saturated aqueous antitumor quinone solutions resulted in an enhancement in ferricytochrome c (Cyt c) reduction. Partial inhibition of these reduction enhancements by addition of superoxide dismutase evidences the production of superoxide ions. No correlation between quinone hydrophobicity or redox potential is observed in the extent of Cyt c reduction. The semiquinone of the parent quinone as well as other quinone-derived reductants are proposed as the electron shuttle intermediates which reduce Cyt c.
Lopez-Colón
Dalia
D
Department of Chemistry, University of Puerto Rico at Humacao, CUH Station, Humacao 00791, Puerto Rico.
Alegría
Antonio E
AE
D000970:Antineoplastic Agents / Q000737:chemistry*; D001128:Argon / Q000737:chemistry; D001388:Aziridines / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry; D045304:Cytochromes c / Q000737:chemistry*; D010084:Oxidation-Reduction; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013010:Sonication; D013482:Superoxide Dismutase; D013481:Superoxides / Q000737:chemistry; D013997:Time Factors; D014465:Ultrasonics
D000970:Antineoplastic Agents; D001388:Aziridines; D016227:Benzoquinones; D011809:Quinones; D012996:Solutions; D013481:Superoxides; D001128:Argon; D045304:Cytochromes c; D013482:Superoxide Dismutase; C029108:diaziquone