Identification and measurement of genomic biomarkers of nephrotoxicity.
An accelerated pace for drug discovery and development requires the application of measurements of novel parameters for drug-induced toxicity. Genomic biomarkers can contribute to this process as indicators or predictors of toxicity. Transcript levels for genes such as the kidney injury molecule have been identified and evaluated as genomic biomarkers of nephrotoxicity.
Goodsaid
Federico M
FM
Department of Genetic and Molecular Toxicology, Schering-Plough Research Institute, 144 Route 94, Lafayette, NJ 07871, USA. federico.goodsaid@fluidigm.com
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced*; D015870:Gene Expression / Q000187:drug effects; D023281:Genomics; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D043922:Toxicogenetics
D015415:Biomarkers