Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.
Results of this study support the free-radical theory of aging and demonstrated that providing higher levels of vitamin E in food resulted in higher serum vitamin E concentrations and improved performance on landmark-discrimination tasks in aged dogs. Factors other than vitamin E also contributed to the response but remain undefined.
Ikeda-Douglas
Candace J
CJ
Department of Life Sciences, University of Toronto at Scarborough, Toronto, Ontario, M1C 1A4, Canada.
Zicker
Steven C
SC
Estrada
Jimena
J
Jewell
Dennis E
DE
Milgram
Norton W
NW
D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002331:Carnitine / Q000008:administration & dosage / Q000494:pharmacology; D004032:Diet; D004193:Discrimination Learning / Q000187:drug effects* / Q000502:physiology*; D004215:Distance Perception; D004285:Dogs / Q000502:physiology; D008063:Thioctic Acid / Q000008:administration & dosage / Q000494:pharmacology; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D008063:Thioctic Acid; D002331:Carnitine