title: R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men.
abstract: BACKGROUND
  The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial.
  
  
  RESULTS
  The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1+/-40.9 U/L) than in controls (44.8+/-20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7+/-15.7%) and controls (87.0+/-9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001).
  
  
  CONCLUSIONS
  The Q allele may be protective against premature MI.
authors.affiliation: Department of Cardiovascular, Graduate School of Medicine, Kagoshima University, Japan.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ogawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Abe
authors.forename: Sadatoshi
authors.initials: S
authors.lastname: Biro
authors.forename: Masahiko
authors.initials: M
authors.lastname: Saigo
authors.forename: Takashi
authors.initials: T
authors.lastname: Kihara
authors.forename: Shiro
authors.initials: S
authors.lastname: Setoyama
authors.forename: Tatsuru
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Toda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Torii
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Atsuchi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Toyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tateishi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Minagoe
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
authors.forename: Chuwa
authors.initials: C
authors.lastname: Tei
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D015942:Factor VIIa / Q000032:analysis / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: D015942:Factor VIIa