Enantioselective synthesis of (+)-8-hydroxy-8-methylidarubicinone.
An asymmetric Diels-Alder reaction methodology was employed to construct the tetracyclic structure of the anthracyclinone. A five-step sequence was needed to furnish the target (+)-8-hydroxy-8-methylidarubicinone.
Bourghli
Laurance M S
LM
Department of Organic Materials, Royal Scientific Society, Industrial Chemistry Center, Amman, Jordan. bourshli@rss.gov.jo
Stoodley
R J
RJ
D018943:Anthracyclines / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D013237:Stereoisomerism
C495006:8-hydroxy-8-methylidarubicinone; D018943:Anthracyclines; D000970:Antineoplastic Agents; D015255:Idarubicin