title: Dengue: an arthropod-borne disease of global importance.
abstract: Dengue viruses cause a variable spectrum of disease that ranges from an undifferentiated fever to dengue fever to the potentially fatal dengue shock syndrome. Due to the increased incidence and geographical distribution of dengue in the last 50 years, dengue is becoming increasingly recognised as one of the world's major infectious diseases. This article will review clinical and diagnostic aspects of dengue virus infections. It also presents our current knowledge of the pathophysiology of severe dengue and addresses the importance of dengue virus infections in those travelling to parts of the world where dengue is endemic.
authors.affiliation: Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. igrmr@slz.nl
authors.forename: A T A
authors.initials: AT
authors.lastname: Mairuhu
authors.forename: J
authors.initials: J
authors.lastname: Wagenaar
authors.forename: D P M
authors.initials: DP
authors.lastname: Brandjes
authors.forename: E C M
authors.initials: EC
authors.lastname: van Gorp
mesh_terms: D000818:Animals; D003716:Dengue Virus / Q000302:isolation & purification*; D004196:Disease Outbreaks; D019353:Endemic Diseases; D005260:Female; D014943:Global Health; D006801:Humans; D015994:Incidence; D017053:Infection Control; D008297:Male; D009032:Mosquito Control; D012307:Risk Factors; D019595:Severe Dengue / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy*