Neural synchronization deficits to auditory stimulation in bipolar disorder.
Patients with bipolar disorder show cognitive deficits and disorganized behavior, which may reflect a disturbance in neural synchronization. We tested whether EEG measures of auditory neural synchronization were abnormal in bipolar disorder. Nineteen symptomatic patients with bipolar disorder and 32 non-psychiatric control subjects were evaluated. Click trains (500 ms duration) presented at 20, 30, 40 and 50 Hz were used to evoke EEG synchronization. Patients with bipolar disorder showed reduced power across the frequencies of stimulation. Phase-locking across trials was also disturbed in bipolar disorder, consistent with poor phase synchronization between the stimulus and EEG. Abnormal high frequency neural synchronization may contribute to cognitive deficits in bipolar disorder.
O'Donnell
Brian F
BF
Department of Psychology, Indiana University, Bloomington, IN 47405, USA. bodonnel@indiana.edu
Hetrick
William P
WP
Vohs
Jenifer L
JL
Krishnan
Giri P
GP
Carroll
Christine A
CA
Shekhar
Anantha
A
D000161:Acoustic Stimulation; D000328:Adult; D001308:Auditory Perceptual Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D001714:Bipolar Disorder / Q000150:complications / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D003344:Cortical Synchronization; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000172:deficiency
D005680:gamma-Aminobutyric Acid