title: Decrease of CD154 intensity on peripheral CD4+ T cells in autoimmune thyroid disease.
abstract: To clarify immunological differences among patients with Graves' disease (GD) and Hashimoto's disease (HD) at various levels of severity, we examined the expression of the CD154 molecules on peripheral T cells, which regulate B cell activation, B cell differentiation, and T-cell survival. We found decreases in the intensities of CD154 on peripheral CD4(+) cells from euthyroid patients with GD and HD, but we did not find any differences between patients with different disease severities. CD8(+) cells did not express CD154 molecules. Thus, CD154 expression on CD4(+) cells may be related to the pathogenesis of the autoimmune thyroid diseases, not to the disease severity.
authors.affiliation: Division of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Yamamoto
authors.forename: F
authors.initials: F
authors.lastname: Matsuzuka
authors.forename: A
authors.initials: A
authors.lastname: Miyauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Iwatani
mesh_terms: D000328:Adult; D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D023201:CD40 Ligand / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006111:Graves Disease / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
chemical_list: D023201:CD40 Ligand