In vivo 31P-MRS assessment of muscle-pH, cytolsolic-[Mg2+] and phosphorylation potential after supplementing hypokaliuric renal stone patients with potassium and magnesium salts.
Renal stone patients in rural northeast Thailand have a low potassium and magnesium status and low urinary excretion of citrate. We measured the changes of urinary citrate excretion and assessed in vivo skeletal muscle metabolism for intracellular-pH, cytosolic-[Mg(2+)] and phosphorylation potential (using the phosphorus magnetic resonance spectroscopy (31)P-MRS) after oral supplementation to hypokaliuric renal stone patients with oral potassium and magnesium salts. The patients comprised four groups: Group 1 (n = 10) control, Group 2 (n = 3), Group 3 (n = 5) and Group 4 (n = 6) supplemented for a month with potassium citrate, potassium citrate plus amino acid chelated magnesium, and potassium-magnesium citrate, respectively. Though urinary citrate excretion was increased in all three supplemented groups, the increases in intracellular-pH, cytosolic-[Mg(2+)] and phosphocreatine (PCr)/beta-ATP were prominent only in Group 3. The increase in PCr/beta-ATP was also observed in Group 4.
Mairiang
Eimorn
E
Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. eimmai@kku.ac.th
Hanpanich
Petcharakorn
P
Sriboonlue
Pote
P
D000328:Adult; D002951:Citrates / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D019343:Citric Acid / Q000652:urine; D019587:Dietary Supplements; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007669:Kidney Calculi / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D008274:Magnesium / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D010759:Phosphorus Isotopes; D010766:Phosphorylation; D011188:Potassium / Q000008:administration & dosage / Q000378:metabolism / Q000652:urine*; D011191:Potassium Deficiency / Q000188:drug therapy / Q000652:urine
D002951:Citrates; D010759:Phosphorus Isotopes; D019343:Citric Acid; D008274:Magnesium; D011188:Potassium