Methotrexate-induced leukoencephalopathy reversed by aminophylline and high-dose folinic acid.
Jaksic
Wilfrid
W
Department of Haematology/Oncology, Queen Elizabeth Hospital, Woodville, Australia. jaksic@chariot.net.au
Veljkovic
Dusan
D
Pozza
Chris
C
Lewis
Ian
I
D000328:Adult; D000628:Aminophylline / Q000008:administration & dosage* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage* / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000009:adverse effects*; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
D000628:Aminophylline; D002955:Leucovorin; D008727:Methotrexate