Factors associated with severe impact of lipodystrophy on the quality of life of patients infected with HIV-1.
A standardized questionnaire was used to assess the impact of lipodystrophy (LD) on quality of life (QoL). Eighty-four consecutive asymptomatic human immunodeficiency virus type 1 (HIV-1)-infected outpatients with clinical LD completed a modified version of the Dermatology Life Quality Index (DLQI) survey to measure the impact of body fat changes on their QoL. Body changes influenced dressing for 55 patients (65%), produced feelings of shame for 41 (49%), and disrupted sexual life for 23 (27%). There was a greater impact on the DLQI due to body changes among women, injection drug users, patients with abdominal or breast lipoaccumulation, and patients with a high number of non-LD side effects. Multivariate proportional odds model analysis showed that the severity of non-LD-associated side effects and the presence of breast lipoaccumulation were associated with impaired psychosocial functioning. Specific characteristics of patients, antiretroviral-based side effects, and breast lipoaccumulation exert a greater impact on QoL in HIV-1-infected patients with LD.
Blanch
Jordi
J
Clinical Institute of Psychiatry and Psychology, Hospital Clínic Universitari de Barcelona, 08036 Barcelona, Spain. jblanch@clinic.ub.es
Rousaud
Araceli
A
Martinez
Esteban
E
De Lazzari
Elisa
E
Milinkovic
Ana
A
Peri
Josep-Maria
JM
Blanco
José-Luis
JL
Jaen
Jesús
J
Navarro
Victor
V
Massana
Guillem
G
Gatell
Josep-Maria
JM
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D015497:HIV-1; D006801:Humans; D008060:Lipodystrophy / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D008297:Male; D015999:Multivariate Analysis; D011788:Quality of Life