title: Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction.
abstract: BACKGROUND
  Cyclooxygenase-2 (COX-2) has been reported to play an important role in the pathogenesis of a variety of cancers. Little is known about the relationship between bile duct cancer associated with pancreaticobiliary maljunction (PBM) and COX-2.
  
  
  METHODS
  We compared the expression of COX-2 in bile duct epithelium in bile duct cancer with or without PBM.
  
  
  RESULTS
  Immunohistochemical analysis showed that the rate of positive COX-2 expression was 42.9% for cancerous lesions and 7.1% for noncancerous lesions in cases of bile duct cancer without PBM. On the other hand, no positive expression of COX-2 was observed in cancerous lesion of bile duct cancer with PBM. Twenty % of the noncancerous bile duct mucosa with PBM was positive for COX-2.
  
  
  CONCLUSIONS
  COX-2 is expressed in bile duct cancer while it is not expressed in bile duct cancer accompanied by PBM.
authors.affiliation: Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Watanabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yoshimatsu
authors.forename: Shunichi
authors.initials: S
authors.lastname: Shiozawa
authors.forename: Akira
authors.initials: A
authors.lastname: Tsuchiya
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Oshibe
authors.forename: Motohiko
authors.initials: M
authors.lastname: Aiba
authors.forename: Kenji
authors.initials: K
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications / Q000201:enzymology* / Q000473:pathology; D015529:Choledochal Cyst / Q000150:complications / Q000201:enzymology*; D051546:Cyclooxygenase 2; D004848:Epithelium / Q000201:enzymology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D008565:Membrane Proteins; D009367:Neoplasm Staging; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis*
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases