title: Primitive neuroectodermal tumor (PNET) of the uterine isthmus.
abstract: Primitive neuroectodermal tumors (PNETs) of the uterus are very rare. The histogenesis of these tumors is still unknown and the differential diagnosis includes a wide variety of tumor entities. We describe a rare case of a 68-year-old female who presented with persistent vaginal bleeding. Physical examination and CT-scan revealed a large tumor in the uterus. Macroscopically the tumor involved the uterine isthmus. Histological and immunohistochemical examination showed that the tumor fulfilled the diagnostic criteria set for PNET. Only a very small number of cases of PNETs of the uterus have been reported in the literature, thus no definitive conclusions concerning the therapeutic management and prognosis have been ascertained.
authors.affiliation: Department of Pathology, Hippokrateio General Hospital, Thessaloniki, Greece.
authors.forename: I D
authors.initials: ID
authors.lastname: Venizelos
authors.forename: M
authors.initials: M
authors.lastname: Zafrakas
authors.forename: K
authors.initials: K
authors.lastname: Dragoumis
authors.forename: P
authors.initials: P
authors.lastname: Tzevelekis
authors.forename: D
authors.initials: D
authors.lastname: Kellartzis
authors.forename: J
authors.initials: J
authors.lastname: Bontis
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011859:Radiography; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery