[Experimental study on the in vitro resistance to Toxoplasma gondii by murine lymphocyte].
OBJECTIVE
To study the activities of in vitro resistance to the tachyzoite of Toxoplasma gondii by murine lymphocytes.


METHODS
The rat's splenocyte culture method was used to observe the effects of lymphocytes themselves and lymphocytes together with Mandelic( MA) on the invasion and proliferation of T. gondii in lymphocytes. At the same time acetylspiramycin was used as positive control.


RESULTS
As compared with other somatic cells, the lymphocytes invaded by T. gondii still inhibited and killed the toxoplasma organisms in the presence of immunity, the effect safety dose of MA on inhibition of the invasion of T. gondii was not notable while the inhibition of the proliferation of T. gondii in lymphocytes was remarkable.


CONCLUSIONS
Cell-mediated immunity(CMI) was an important factor that host resists the T. gondii infection. So, we should pay attention to improving the organism's CMI and take proper medicine so as to enhance the effect of lymphocyte's resistance to T. gondii.
Shi
Qi
Q
Department of Immunology, Medical College of Xi'an Jiaotong University, Xi'an 710061, China. huaxz76@sohu.com
Hao
Bing-hua
BH
Zhou
Yu-ling
YL
Shi
Xing-min
XM
Yang
An-ning
AN
Zhang
Jin
J
Cheng
Yan-bin
YB
Li
Zhe
Z
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000276:immunology*; D008333:Mandelic Acids / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D015572:Spiramycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014122:Toxoplasma / Q000187:drug effects / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology
D008333:Mandelic Acids; C033163:acetylspiramycin; D015572:Spiramycin; C037938:mandelic acid