Lingshuiol, a novel polyhydroxyl compound with strongly cytotoxic activity from the marine dinoflagellate Amphidinium sp.
A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC(50) of 0.21 and 0.23 microM, respectively.
Huang
Xiao-Chun
XC
State key laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Zhangjiang High-Tech Park, Shanghai 201203, China.
Zhao
Di
D
Guo
Yue-Wei
YW
Wu
Hou-Ming
HM
Lin
Li-Ping
LP
Wang
Zhong-Hua
ZH
Ding
Jian
J
Lin
Yong-Shui
YS
D000475:Alkenes / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000302:isolation & purification* / Q000494:pharmacology*; D004141:Dinoflagellida; D018922:HL-60 Cells; D006801:Humans; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology
D000475:Alkenes; D003603:Cytotoxins; D011714:Pyrans