title: Quantitative analysis of radiation-induced chromosome aberrations.
abstract: We review chromosome aberration modeling and its applications, especially to biodosimetry and to characterizing chromosome geometry. Standard results on aberration formation pathways, randomness, dose-response, proximity effects, transmissibility, kinetics, and relations to other radiobiological endpoints are summarized. We also outline recent work on graph-theoretical descriptions of aberrations, Monte-Carlo computer simulations of aberration spectra, software for quantifying aberration complexity, and systematic links of apparently incomplete with complete or truly incomplete aberrations.
authors.affiliation: Department of Mathematics, University of California at Berkeley, Berkeley, CA 94720, USA. sachs@math.berkeley.edu
authors.forename: R K
authors.initials: RK
authors.lastname: Sachs
authors.forename: D
authors.initials: D
authors.lastname: Levy
authors.forename: P
authors.initials: P
authors.lastname: Hahnfeldt
authors.forename: L
authors.initials: L
authors.lastname: Hlatky
mesh_terms: D000818:Animals; D002455:Cell Division; D002869:Chromosome Aberrations; D019457:Chromosome Breakage; D002875:Chromosomes / Q000528:radiation effects* / Q000648:ultrastructure; D003198:Computer Simulation; D004247:DNA / Q000235:genetics; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008957:Models, Genetic; D009010:Monte Carlo Method
chemical_list: D004247:DNA