[The effect of comorbidity on prognosis in patients with COPD].
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of death from causes other than COPD. A study was undertaken to identify the most common comorbid diseases and to assess prognostic role of comorbidity in COPD. A cohort of 406 COPD patients, mean (+/- SD) 64 +/- 9 years were evaluated. Age, sex, smoking history, FEV1, comorbid conditions were recorded. Follow-up was conducted by means of telephone calls. Logistic regression analysis was used to identify the independent predictors of death. The mean (+/- SD) FEV1 was 1.40 +/- 0.58 L. The most common comorbid diseases were hypertension (22%), coronary heart disease (8.9%), diabetes mellitus (7.4%), cancer (6.4%), heart failure (4.9%) and cerebrovascular disease (2%). The median follow-up was (+/- SD) 21 +/- 11 months. Twenty-four (5.9%) patients died during the follow-up period. Deaths from COPD were associated with FEV1 [RR 0.143 (95% CI 0.75-1.21)], heart failure (RR 0.177) and cancer (RR 0.064). In conclusion; while the most common comorbid diseases in COPD were hypertension, coronary heart disease and diabetes mellitus; FEV1, heart failure and cancer were associated factors with increased risk of death from COPD.
Cilli
Aykut
A
Akdeniz University Faculty of Medicine, Pulmonary Diseases, Antalya, Turkey. acilli@akdeniz.edu.tr
Uslu
Ahmet
A
Oğüş
Candan
C
Ozdemir
Tülay
T
D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000401:mortality; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000401:mortality; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000401:mortality; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality; D011379:Prognosis; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000453:epidemiology* / Q000401:mortality; D012907:Smoking; D014421:Turkey / Q000453:epidemiology