title: Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice.
abstract: The antiproliferative effect of serotonin-reuptake inhibitors (SSRI) and serotonin antagonists has been demonstrated in prostate tumors. Since Hypericum perforatum components act as serotonin-reuptake inhibitors and exert cytotoxic effects on several human cancer cell lines, in this work we analyzed the effect of a treatment with Hypericum perforatum extract (HPE) on the growth of human prostate cancer cells in vitro and in vivo. This study highlighted a significant reduction of tumor growth and number of metastasis suggesting that this natural compound may be useful in the treatment of prostate cancer.
authors.affiliation: Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, ViaMarcello Scalzino 3, Camerino (MC) 62032, Italy. daniele.martarelli@unicam.it
authors.forename: D
authors.initials: D
authors.lastname: Martarelli
authors.forename: B
authors.initials: B
authors.lastname: Martarelli
authors.forename: D
authors.initials: D
authors.lastname: Pediconi
authors.forename: M I
authors.initials: MI
authors.lastname: Nabissi
authors.forename: M
authors.initials: M
authors.lastname: Perfumi
authors.forename: P
authors.initials: P
authors.lastname: Pompei
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D000432:Methanol / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D010936:Plant Extracts / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000517:prevention & control*; D014407:Tumor Cells, Cultured / Q000637:transplantation
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D000432:Methanol