title: Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis.
abstract: Gelatinase and serine protease were found to contribute in concert to pathogenesis in a rabbit model of endophthalmitis. However, a mutant defective in the fsr regulator was observed to be more attenuated than a mutant rendered defective in the expression of gelatinase and serine protease as the result of a polar transposon insertion into the former. This increased attenuation suggests that there are possible additional pleiotropic effects of the defect in fsr on expression of traits contributing to the pathogenesis of enterococcal infection.
authors.affiliation: Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Engelbert
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Mylonakis
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Ausubel
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Calderwood
authors.forename: Michael S
authors.initials: MS
authors.lastname: Gilmore
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D009877:Endophthalmitis / Q000382:microbiology / Q000473:pathology*; D013293:Enterococcus faecalis / Q000201:enzymology / Q000235:genetics / Q000472:pathogenicity*; D005123:Eye / Q000382:microbiology / Q000473:pathology; D005260:Female; D018093:Gelatinases / Q000378:metabolism*; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology / Q000473:pathology; D009154:Mutation; D011817:Rabbits; D012697:Serine Endopeptidases / Q000378:metabolism*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D012697:Serine Endopeptidases; D018093:Gelatinases