title: Botulinum toxin for masseter reduction in Asian patients.
abstract: Asian patients frequently seek aesthetic alteration of hypertrophic masseter muscles to reduce a prominent mandibular angle. Surgical reduction is common in Asia, but botulinum toxin offers a less invasive approach. This pilot study evaluated results of aesthetic lower face narrowing in 20 Asian patients. Initially, 25 U of botulinum toxin (5 U/0.1 mL) was injected at each inferior masseter border; an additional 25 U was injected per side as needed at 1-week intervals. Seven patients (35%) required only 1 injection; 10 (50%) required 2; and 3 (15%) required 3 injections. Maximum reduction was seen at 1 to 2 months; more prominent hypertrophy yielded the most impressive results. Maintenance reinjection took place at 6 to 8 months. Up to 12 months of follow-up is reviewed herein. Two patients (10%) complained of mild fatigue after vigorous chewing and 1 developed mild transient buccal weakness. Nineteen of 20 patients were satisfied.
authors.affiliation: Departments of Otolaryngology-Head and Neck Surgery of New York Presbyterian Hospital, New York, NY 10032, USA. jma2@columbia.edu
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Ahn
authors.forename: Corinne
authors.initials: C
authors.lastname: Horn
authors.forename: Andrew
authors.initials: A
authors.lastname: Blitzer
mesh_terms: D000293:Adolescent; D000328:Adult; D001208:Asia / Q000208:ethnology; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D003357:Cosmetic Techniques; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007273:Injections, Intramuscular; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects* / Q000473:pathology; D009465:Neuromuscular Agents / Q000008:administration & dosage*; D010865:Pilot Projects
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A