In vitro effects of albendazole sulfoxide and praziquantel against Taenia solium and Taenia crassiceps cysts.
We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ.
Palomares
Francisca
F
Laboratorio de Neuropsicofarmacología, Instituto Nacional de Neurología y Neurocirugía, Facultad de Química, Insurgentes Sur 3877, Col. La Fama, Tlalpan 14269, México City, México.
Palencia
Guadalupe
G
Pérez
Rodolfo
R
González-Esquivel
Dinora
D
Castro
Nelly
N
Cook
Helgi Jung
HJ
D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000980:Antiplatyhelmintic Agents / Q000494:pharmacology*; D003551:Cysticercosis / Q000469:parasitology* / Q000473:pathology; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011223:Praziquantel / Q000494:pharmacology*; D013552:Swine; D013621:Taenia / Q000187:drug effects*; D041201:Taenia solium / Q000187:drug effects*
D000871:Anthelmintics; D000980:Antiplatyhelmintic Agents; D011223:Praziquantel; D015766:Albendazole