Recurrent pregnancy loss and its relation to FV Leiden, FII G20210A and polymorphisms of plasminogen activator and plasminogen activator inhibitor.
Thrombophilic disorders and hypofibrinolysis were demonstrated to be risk factors in a majority of women with recurrent pregnancy loss (RPL) and infertility. We investigated the association of FV G1691A mutation, F II G20210A gene polymorphism (PM), 4G/5G PAI-1 and Alu I/D tPA PM in 32 women with infertility and 49 women with at least 2 unexplained early abortions. FV Leiden mutation was significantly more common in women with RPL (10%, p = 0.02) and infertility (19%, p = 0.0005) compared with controls (2%). PAI-1 4G PM and t-PA Alu I PM, alone or in combination, were not associated with RPL or infertility. 9/49 women with RPL showed coagulation disorders with heterozygous FV Leiden mutation (5), FXII (1), protein C (1) or protein S (2) deficiency. However, due to the small number of patients studied, no definite conclusion can be drawn.
Wolf
Cornelia E
CE
Department of Transfusion Medicine, University of Göttingen, Göttingen, Germany. cwolf@med.uni-goettingen.de
Haubelt
Hannelore
H
Pauer
Hans Ulrich
HU
Hinney
Bernd
B
Krome-Cesar
Claudette
C
Legler
Tobias J
TJ
Hellstern
Peter
P
Emons
Günter
G
Zoll
Barbara
B
Köhler
Michael
M
D000026:Abortion, Habitual / Q000097:blood* / Q000209:etiology / Q000235:genetics; D000328:Adult; D001779:Blood Coagulation Factors / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005165:Factor V; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology / Q000235:genetics; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics; D010960:Plasminogen Activators / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000150:complications
D001779:Blood Coagulation Factors; D017395:Plasminogen Activator Inhibitor 1; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D010960:Plasminogen Activators