title: Employment opportunities for non-coding RNAs.
abstract: Analysis of the genomes of several higher eukaryotic organisms, including mouse and human, has reached the striking conclusion that the mammalian transcriptome is constituted in large part of non-protein-coding transcripts. Conversely, the number of protein-coding genes was initially at least overestimated. A growing number of studies report the involvement of non-coding transcripts in a large variety of regulatory processes. This review examines the different types of non-coding RNAs (ncRNAs) and discusses their putative mode of action with particular reference to large ncRNAs and their role in epigenetic regulation.
authors.affiliation: Génétique Moléculaire Murine CNRS 2578, Institut Pasteur, 25, rue du Docteur Roux, 75015 Paris, France. cmorey@pasteur.fr
authors.forename: Céline
authors.initials: C
authors.lastname: Morey
authors.forename: Philip
authors.initials: P
authors.lastname: Avner
mesh_terms: D000465:Algorithms; D000818:Animals; D002843:Chromatin / Q000737:chemistry; D004303:Dosage Compensation, Genetic; D016678:Genome; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D016366:Open Reading Frames; D012313:RNA / Q000737:chemistry* / Q000502:physiology; D022661:RNA, Untranslated / Q000737:chemistry*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D016376:Oligonucleotides, Antisense; D022661:RNA, Untranslated; D012313:RNA