title: [Clinical significance of six-transmembrane epithelial antigen of the prostate expressed in prostatic carcinoma].
abstract: OBJECTIVE
  To investigate the relationship between six-transmembrane epithelial antigen of the prostate (STEAP) expression and the histologic grading of prostatic carcinoma (PCa).
  
  
  METHODS
  Different prostatic tissues and non-prostatic tumors, 131 cases of PCa, 164 cases of benign prostate hyperplasia (BPH), and 56 cases of non-prostatic malignancies, were analyzed for the expression of STEAP by using STEAP monoclonal antibody and SP immunohistochemical staining. The positive area unit (PU) was introduced to describe the intensity of STEAP expression.
  
  
  RESULTS
  The prostatic tissues of all but 3 cases of PCa and 5 cases of BPH were stained positively, while all of the non-prostatic tumors were stained negatively. There was a significant negative correlation between the STEAP expression and the histologic grading of PCa.
  
  
  CONCLUSIONS
  STEAP can be a prognostic marker of PCa and a potential therapeutic target in PCa.
authors.affiliation: Department of Urology, First Affiliated Hospital, Zhejiang University Medical College, Hangzhou, Zhejiang 310003, China. liliaoyuan@zju.edu.cn
authors.forename: Liaoyuan
authors.initials: L
authors.lastname: Li
authors.forename: Jiefang
authors.initials: J
authors.lastname: Li
authors.forename: Zhoujun
authors.initials: Z
authors.lastname: Shen
authors.forename: Weijun
authors.initials: W
authors.lastname: Liu
authors.forename: Zhaodian
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010088:Oxidoreductases; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D010088:Oxidoreductases; C432763:STEAP1 protein, human