Amidine derived 1,3-diazabuta-1,3-dienes as potential antibacterial and antifungal agents.
Several 1-aryl-2-phenyl-4-piperidino-4-thioalkyl-1,3-diazabuta-1,3-dienes were prepared by the treatment of N-arylimino isothiocyanate with piperidine followed by S-alkylation with alkyl iodides in the presence of dry acetone and potassium hydroxide. The constitution of the products was supported by IR, PMR and mass spectral study. The compounds synthesized were tested in in vitro against E. coli, S. aureus, P. aeruginosa, B. cereus and B. subtilis and fungal stains, Candida albicans and Aspergillus niger. Standard drugs were also tested under identical conditions for comparing the results.
Bedi
Preet M S
PM
Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, Punjab, India. bedi_preet@yahoo.com
Mahajan
Mohinder P
MP
Kapoor
Vijay K
VK
D000478:Alkylation; D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002070:Butadienes / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D017879:Isothiocyanates / Q000737:chemistry; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry
D000578:Amidines; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002070:Butadienes; D017879:Isothiocyanates; D010880:Piperidines; C037152:isothiocyanic acid; C032727:piperidine