[Improvement in postural orientation and stability after stereotactic gamma irradiation of acoustic neurinomas].
Non-surgical stereotactic gamma ionizing irradiation was developed in order to produce a lethal effect on unilateral acoustic neurinomas (vestibular schvannomas). We present a study of postural vestibular dependent performances in 218 patients before and after curative irradiation. Subjects were asked to stand at ease on a static dynamometric foot-plate, gazing at a fixed point in front of them (EO condition) or to stand eyes closed (EC condition). Statokinesigrams were registered during two consecutive sessions of 51.2 sec, under EO and EC conditions. These sessions were first managed the days before (d-1), and after (d+1) irradiation; others were performed later (d+1 to 5 Years; n=37). Center of pressure (CofP) mediolateral (X) and sagittal (Y) positions were quantified every 100 msec. Mean Xm session value (with SD) was taken as a personal parameter for left or right body inclination. Area S for 90% of the XY successive placements of the CofP observed during a session was taken as an index for 2D postural way. Before irradiation the overall average of the 218 personal Xm mean values demonstrated a statistically significant body inclination toward the affected side, however under EC condition only. The day after irradiation, a significant reduction of the overall mean value of body inclination was observed. Paired Xm statistics of confirmed this trend toward usual symmetry. The day after stereo-irradiation, averaging areas S of ellipses indicated a shift of instability toward normality. For the two parameters, the pseudo-Romberg ratios (performance EC/performance EO) indicated that a special visual contribution to balance control is present in patients with a neurinoma tumor (here I and II grades). The relative importance of this visual support declined shortly after ionizing treatment. Because the radiation is neither noxious nor excitatory we think such a rapid recovery is due to some recovery of vestibular nerve afferent conduction, and a rapid neural reprogramming of the balance control. These attractive results call for deeper investigations of both vestibular and auditory functions.
Ouaknine
M
M
Laboratoire d'Audio-Phonologie Clinique, UPRES EA 2668, Hôpital d'Adulte de la Timone, Marseille. ouaknine@univ-aix.fr
Hugon
M
M
Roman
S
S
Thomassin
J-M
JM
Sarabian
N
N
Régis
J
J
D015331:Cohort Studies; D004428:Ear Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D005260:Female; D006311:Hearing Disorders / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009464:Neuroma, Acoustic / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011184:Postoperative Period; D011187:Posture; D016634:Radiosurgery / Q000295:instrumentation*; D012720:Severity of Illness Index