A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen.
Tamoxifen significantly reduces tumor recurrence in certain patients with early-stage estrogen receptor-positive breast cancer, but markers predictive of treatment failure have not been identified. Here, we generated gene expression profiles of hormone receptor-positive primary breast cancers in a set of 60 patients treated with adjuvant tamoxifen monotherapy. An expression signature predictive of disease-free survival was reduced to a two-gene ratio, HOXB13 versus IL17BR, which outperformed existing biomarkers. Ectopic expression of HOXB13 in MCF10A breast epithelial cells enhances motility and invasion in vitro, and its expression is increased in both preinvasive and invasive primary breast cancer. The HOXB13:IL17BR expression ratio may be useful for identifying patients appropriate for alternative therapeutic regimens in early-stage breast cancer.
Ma
Xiao-Jun
XJ
Arcturus Bioscience, Inc., 2715 Loker Avenue West, Carlsbad, CA 92008, USA.
Wang
Zuncai
Z
Ryan
Paula D
PD
Isakoff
Steven J
SJ
Barmettler
Anne
A
Fuller
Andrew
A
Muir
Beth
B
Mohapatra
Gayatry
G
Salunga
Ranelle
R
Tuggle
J Todd
JT
Tran
Yen
Y
Tran
Diem
D
Tassin
Ana
A
Amon
Paul
P
Wang
Wilson
W
Wang
Wei
W
Enright
Edward
E
Stecker
Kimberly
K
Estepa-Sabal
Eden
E
Smith
Barbara
B
Younger
Jerry
J
Balis
Ulysses
U
Michaelson
James
J
Bhan
Atul
A
Habin
Karleen
K
Baer
Thomas M
TM
Brugge
Joan
J
Haber
Daniel A
DA
Erlander
Mark G
MG
Sgroi
Dennis C
DC
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D020381:Interleukin-17 / Q000096:biosynthesis / Q000235:genetics*; D016015:Logistic Models; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012372:ROC Curve; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013629:Tamoxifen / Q000627:therapeutic use*; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; C484414:HOXB13 protein, human; D018398:Homeodomain Proteins; D020381:Interleukin-17; D013629:Tamoxifen