title: The left ventricular apex is the optimal site for pediatric pacing: correlation with animal experience.
abstract: Pacing at the commonly used right ventricular (RV) apex results in impaired ventricular performance. Previous animal studies indicated that the left ventricular (LV) apex is a superior pacing site. The purpose of this study was to investigate in dogs whether this good performance is associated with a more synchronous electrical activation pattern of the LV and whether the LV apex is also a good pacing site in children. In 11 healthy dogs and 8 children undergoing cardiac surgery, dual chamber pacing was performed at the RV apex, LV apex and LV lateral free wall (LVFW). In dogs, a basket electrode was inserted into the LV to assess pattern and timing of LV endocardial activation. In the children, hemodynamic measurements were performed immediately after recovery from cardiopulmonary bypass. In dogs, LV apex pacing resulted in synchronous activation around the LV circumference whereas RV apex and LVFW pacing resulted in asynchrony of activation between the septum and LVFW. In both canine and children's hearts most hemodynamic variables remained at sinus rhythm level during LV apex pacing, but LVdPdtmax, stroke work (dogs), and pulse pressure (children) were reduced as compared with sinus rhythm during RV apex and LVFW pacing. LV apex pacing results in synchronous activation of the LV and is, in adult dogs and in children, associated with superior hemodynamic performance.
authors.affiliation: Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands.
authors.forename: Ward Y
authors.initials: WY
authors.lastname: Vanagt
authors.forename: Xander A
authors.initials: XA
authors.lastname: Verbeek
authors.forename: Tammo
authors.initials: T
authors.lastname: Delhaas
authors.forename: Luc
authors.initials: L
authors.lastname: Mertens
authors.forename: Willem J
authors.initials: WJ
authors.lastname: Daenen
authors.forename: Frits W
authors.initials: FW
authors.lastname: Prinzen
mesh_terms: D000293:Adolescent; D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D002675:Child, Preschool; D004285:Dogs; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006330:Heart Defects, Congenital / Q000503:physiopathology* / Q000601:surgery; D006352:Heart Ventricles; D006801:Humans; D007223:Infant; D008297:Male; D013318:Stroke Volume