Nitric oxide metabolites and adrenomedullin in human breast milk.
We found high concentrations of nitrite/nitrate (166-1460 micromol/l) in 43 milk samples obtained from 32 women during postpartum days 1-8, which indicates enhanced mammary nitric oxide (NO) secretion. We detected adrenomedullin (AM) (2.7-20.7 pmol/l) only in 9 of the 43 samples using highly specific immunoradiometric assay. It is uncertain whether the entire adrenomedullin is actively secreted in human milk.
Ohta
Naoko
N
Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Tsukahara
Hirokazu
H
Ohshima
Yusei
Y
Nishii
Manabu
M
Ogawa
Yasuyo
Y
Sekine
Kyouichi
K
Kasuga
Kenkou
K
Mayumi
Mitsufumi
M
D053607:Adrenomedullin; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008895:Milk, Human / Q000737:chemistry*; D009566:Nitrates / Q000032:analysis; D009569:Nitric Oxide / Q000378:metabolism*; D009573:Nitrites / Q000032:analysis; D010455:Peptides / Q000032:analysis*; D049590:Postpartum Period; D013997:Time Factors
D009566:Nitrates; D009573:Nitrites; D010455:Peptides; D053607:Adrenomedullin; D009569:Nitric Oxide