Nodular regenerative hyperplasia of the liver and coeliac disease: potential role of IgA anticardiolipin antibody.
Nodular regenerative hyperplasia (NRH) of the liver is a rare disorder that is often associated with connective tissue disorders, haematological malignancy, or drugs, and is a cause of non-cirrhotic portal hypertension. We describe two cases of NRH in individuals with adult coeliac disease and IgA anticardiolipin antibodies. We discuss the potential impact of this observation on the understanding of the pathogenesis of NRH.
Austin
A
A
The Liver Unit, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham, UK.
Campbell
E
E
Lane
P
P
Elias
E
E
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D002446:Celiac Disease / Q000150:complications / Q000276:immunology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis*; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D017153:Antibodies, Anticardiolipin; D007070:Immunoglobulin A