Microelectrode array fabrication by electrical discharge machining and chemical etching.
Wire electrical discharge machining (EDM), with a complementary chemical etching process, is explored and assessed as a method for developing microelectrode array assemblies for intracortically recording brain activity. Assembly processes based on these methods are highlighted, and results showing neural activity successfully recorded from the brain of a mouse using an EDM-based device are presented. Several structures relevant to the fabrication of microelectrode arrays are also offered in order to demonstrate the capabilities of EDM.
Fofonoff
Timothy A
TA
BioInstrumentation Laboratory, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. fofonoff@mit.edu
Martel
Sylvain M
SM
Hatsopoulos
Nicholas G
NG
Donoghue
John P
JP
Hunter
Ian W
IW
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004563:Electrochemistry / Q000379:methods; D004567:Electrodes, Implanted; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008420:Manufactured Materials; D051379:Mice; D008839:Microelectrodes; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*