title: [Molecular epidemiology of HIV-infection in drug addicts of Southern Ural].
abstract: The analysis of HIV-1 variants circulating among drug addicts in 16 settlements of the Sverdlov, Chelyabinsk and Orenburg regions (72, 90 and 42 patients respectively) was carried out. As shown by the serological analysis, the spread of HIV-1 variant IDU-A among the drug addicts in this area continued in this area and could be detected in 99.5% of the samples (203 out of 204 samples). These data were confirmed by the results of the analysis of 35 samples by the Heteroduplex Mobility Assay for genes env and gag. The analysis of nucleotide sequences of gene env revealed that HIV-1 variants in the Southern Urals, where the greatest outbreak of HIV infection in Russia had been registered, were genetically related to viruses of subtype A, detected earlier in this group of risk in other regions of Russia, as well as in Ukraine, Belarus and other East European countries.
authors.affiliation: Ivanovsky Research Institute of Virology, Federal Research and Methodological Center for Prophylaxis and Control of AIDS, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Kazennova
authors.forename: M R
authors.initials: MR
authors.lastname: Bobkova
authors.forename: V B
authors.initials: VB
authors.lastname: Zemerov
authors.forename: N A
authors.initials: NA
authors.lastname: Shantseva
authors.forename: T A
authors.initials: TA
authors.lastname: Fedotova
authors.forename: L D
authors.initials: LD
authors.lastname: Kiva
authors.forename: T T
authors.initials: TT
authors.lastname: Fedotova
authors.forename: A S
authors.initials: AS
authors.lastname: Kapizov
authors.forename: A T
authors.initials: AT
authors.lastname: Bagautdinov
authors.forename: V E
authors.initials: VE
authors.lastname: Gerasimov
authors.forename: L I
authors.initials: LI
authors.lastname: Seliutina
authors.forename: I R
authors.initials: IR
authors.lastname: Kostian
authors.forename: V I
authors.initials: VI
authors.lastname: Raspopin
authors.forename: V V
authors.initials: VV
authors.lastname: Pokrovskiĭ
authors.forename: A F
authors.initials: AF
authors.lastname: Bobkov
mesh_terms: D015897:Comorbidity; D024202:Electrophoretic Mobility Shift Assay; D015752:Genes, env; D015750:Genes, gag; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000235:genetics; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D020180:Heteroduplex Analysis; D006801:Humans; D017720:Molecular Epidemiology; D010802:Phylogeny; D012426:Russia / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000453:epidemiology* / Q000821:virology
chemical_list: D015699:HIV Envelope Protein gp120