title: Immunohistochemical study of serotonin in lesions of psoriasis.
abstract: OBJECTIVE
  To study the role of serotonin in the pathogenesis of psoriasis.
  
  
  METHODS
  Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with psoriasis.
  
  
  RESULTS
  Expression of serotonin was significantly stronger in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in the progressive stage of psoriasis than in the static stage. There was no difference in serotonin expression between the vulgaris type and the pustular type. No expression of serotonin occurred in the specimens of normal skin.
  
  
  CONCLUSIONS
  Serotonin probably plays an important role in the pathogenesis and activity of psoriasis.
authors.affiliation: Department of Dermatology, People's Hospital of Xiangxi Autonomous Prefecture (the First Affiliated Hospital of Ji-shou University), Ji-shou City, Hunan Province, China. huangjianguo11@sina.com
authors.forename: Jianguo
authors.initials: J
authors.lastname: Huang
authors.forename: Guiming
authors.initials: G
authors.lastname: Li
authors.forename: Jihu
authors.initials: J
authors.lastname: Xiang
authors.forename: Daochun
authors.initials: D
authors.lastname: Yin
authors.forename: Ridong
authors.initials: R
authors.lastname: Chi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology*; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
chemical_list: D012701:Serotonin