Predicting cognitive decline in Alzheimer disease. Role of platelet amyloid precursor protein.
An altered pattern of platelet amyloid precursor protein (APP) forms, consisting of a reduced ratio of the upper (130 kDa) to the lower (110 to 106 kDa) immunoreactivity band (APPr), is associated with Alzheimer disease (AD), although in the early stages of AD this pattern shows high variability. To explore whether APPr values at baseline may predict the rate of cognitive decline, we evaluated patients with mild AD before and after 1 year of treatment with acetylcholinesterase inhibitors. Lower APPr at baseline was the only predictor of progressive cognitive decline, suggesting that this biomarker might be a useful indicator of prognosis for patients with AD.
Borroni
Barbara
B
Department of Neurology, University of Brescia, Brescia, Italy. bborroni@inwind.it
Colciaghi
Francesca
F
Archetti
Silvana
S
Marcello
Elena
E
Caimi
Luigi
L
Di Luca
Monica
M
Padovani
Alessandro
A
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology* / Q000523:psychology; D016564:Amyloid beta-Protein Precursor / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology; D003072:Cognition Disorders / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D005544:Forecasting; D006801:Humans; D007118:Immunoassay; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis
D016564:Amyloid beta-Protein Precursor