title: Age-related differences in parameters of feline immune status.
abstract: In order to assess age-related differences in feline immune status, 101 domestic short haired cats were assigned to two groups, adult (2-5 years, n=50) and senior (10-14 years, n=51). Analyses of leucocyte populations, lymphocyte subsets, complement activity, serum immunoglobulins and acute-phase proteins were undertaken and revealed significant differences between the two groups. The senior group had significantly lower WBC, lymphocyte and eosinophil counts than the adult group. Neutrophil, monocyte and basophil counts did not differ between the groups. Flow cytometry analysis, in combination with differential WBC data, revealed that the absolute values (cells/l) of T-cells, B-cells and natural killer (NK) cells were significantly lower in the older animals. While serum immunoglobulins IgA and IgM were higher in the senior group when compared with the adult group, no significant differences were observed in complement activity or in serum acute-phase proteins. Our findings suggest that age-related changes to parameters of immune status in the feline model are likely to follow a similar pattern to those observed in other long-lived mammalian species.
authors.affiliation: Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland. dj.campbell@ulster.ac.uk
authors.forename: D J
authors.initials: DJ
authors.lastname: Campbell
authors.forename: J M
authors.initials: JM
authors.lastname: Rawlings
authors.forename: S
authors.initials: S
authors.lastname: Koelsch
authors.forename: J
authors.initials: J
authors.lastname: Wallace
authors.forename: J J
authors.initials: JJ
authors.lastname: Strain
authors.forename: B M
authors.initials: BM
authors.lastname: Hannigan
mesh_terms: D000367:Age Factors; D000818:Animals; D001053:Apolipoproteins / Q000097:blood / Q000276:immunology; D002415:Cats / Q000097:blood / Q000276:immunology*; D003124:Colorimetry / Q000662:veterinary; D003165:Complement System Proteins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005434:Flow Cytometry / Q000662:veterinary; D006242:Haptoglobins / Q000276:immunology; D005779:Immunodiffusion / Q000662:veterinary; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007958:Leukocyte Count / Q000662:veterinary; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D000685:Serum Amyloid A Protein / Q000276:immunology; D018709:Statistics, Nonparametric
chemical_list: D001053:Apolipoproteins; D006242:Haptoglobins; D007136:Immunoglobulins; D000685:Serum Amyloid A Protein; D003165:Complement System Proteins