title: Oral nifedipine maintenance therapy after acute intravenous tocolysis in preterm labor.
abstract: OBJECTIVE
  Our aim was to evaluate the efficacy of maintenance oral nifedipine in pregnant women initially treated with intravenous ritodrine plus verapamil for preterm labor.
  
  
  METHODS
  The study included 73 patients with preterm labor with intact membranes. Patients were randomized to receive either maintenance oral nifedipine therapy (n=37) administered 20 mg every six hours or no treatment (controls, n=36) after discontinuation of acute intravenous tocolysis.
  
  
  RESULTS
  Compared to the control group, the mean +/- SD time gained from initiation of maintenance therapy to delivery (26.65 +/- 18.89 vs. 16.14 +/- 12.91 days, p=0.007) and the gestational age at delivery (37.03 +/- 2.06 vs. 35.1 +/- 3 weeks, p=0.003) were higher in the nifedipine maintenance therapy group. The proportion of patients who required one or more courses of subsequent intravenous therapy and perinatal outcomes were similar in the maintenance therapy and control groups.
  
  
  CONCLUSIONS
  The gestational age and time gained from initiation of maintenance therapy to delivery were longer in women receiving oral maintenance tocolysis with nifedipine. However, maintenance therapy did not decrease the recurrence of preterm labor episodes or improve perinatal outcomes.
authors.affiliation: Trakya University, Faculty of Medicine, Department of Obstetrics and Gynecology, Edirne, Turkey. ncsayin@yahoo.com
authors.forename: N Cenk
authors.initials: NC
authors.lastname: Sayin
authors.forename: Füsun G
authors.initials: FG
authors.lastname: Varol
authors.forename: Petek
authors.initials: P
authors.lastname: Balkanli-Kaplan
authors.forename: Müge
authors.initials: M
authors.lastname: Sayin
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D009543:Nifedipine / Q000008:administration & dosage*; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D011256:Pregnancy Outcome; D015149:Tocolytic Agents / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D015149:Tocolytic Agents; D009543:Nifedipine