title: Enhancement of DNA vaccine potency in rhesus macaques by electroporation.
abstract: The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals.
authors.affiliation: Vaccines Research, Chiron Corporation, 4560 Horton St., Mail Stop 4-3, Emeryville, CA 94068, USA.
authors.forename: Gillis
authors.initials: G
authors.lastname: Otten
authors.forename: Mary
authors.initials: M
authors.lastname: Schaefer
authors.forename: Barbara
authors.initials: B
authors.lastname: Doe
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Indresh
authors.initials: I
authors.lastname: Srivastava
authors.forename: Jan
authors.initials: J
authors.lastname: zur Megede
authors.forename: Derek
authors.initials: D
authors.lastname: O'Hagan
authors.forename: John
authors.initials: J
authors.lastname: Donnelly
authors.forename: Georg
authors.initials: G
authors.lastname: Widera
authors.forename: Dietmar
authors.initials: D
authors.lastname: Rabussay
authors.forename: Mark G
authors.initials: MG
authors.lastname: Lewis
authors.forename: Susan
authors.initials: S
authors.lastname: Barnett
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Ulmer
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage* / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D018274:Electroporation / Q000379:methods*; D015683:Gene Products, gag / Q000276:immunology; D008253:Macaca mulatta; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology / Q000494:pharmacology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D000914:Antibodies, Viral; D015683:Gene Products, gag; D019444:Vaccines, DNA; D014765:Viral Vaccines