Analysis of two types of novel alleles in the DXS10011 locus.
A population study of the short tandem repeat locus DXS10011 was carried out in a sample of 104 unrelated Japanese individuals (56 males, 48 females). Thirty-six different alleles were distinguished. The power of discrimination was 0.933 (male) and 0.997 (female). Sequence analysis of alleles was examined for 34 samples. The sequence structures of the alleles were classified into three types: A, B and C. Type A had a regular repeat structure of the repeat region: (GAAA)(n). Types A and B differed in the base sequence of the repeat region. As an A (adenine) insertion in 5' upstream of (GAAA)(n) repeat unit was type C, this type was differentiated from type A.
Tamura
Akiyoshi
A
Department of Legal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki-shi, Osaka 569-8686, Japan. leg003@art.osaka-med.ac.jp
Iwata
Misa
M
Takase
Izumi
I
Miyazaki
Tokiko
T
Matsui
Kiyoshi
K
Nishio
Hajime
H
Suzuki
Koichi
K
D041321:Chromosomes, Human, X / Q000235:genetics; D005260:Female; D005554:Forensic Medicine; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D007564:Japan; D008297:Male; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA / Q000379:methods* / Q000706:statistics & numerical data