title: The role of 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/computed tomography in monitoring the immunosuppressive therapy response of inflammatory myofibroblastic tumor.
abstract: OBJECTIVE
  To compare the pre and post treatment 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) imaging findings of an inflammatory myofibroblastic tumor (IMT) with its clinical response to immunosuppressive therapy.
  
  
  METHODS
  Forty-nine-year-old female presented with dyspnea, chest pain, and weight loss and underwent an FDG-PET/CT scan before and after mediastinal biopsy and treatment with dexamethasone and thalidomide.
  
  
  RESULTS
  FDG-PET/CT scan demonstrated a hypermetabolic mediastinal mass. The biopsy of the lesion was consistent with IMT. Following immunosuppressive therapy, the patient's clinical findings resolved, and PET/CT showed a significant decrease in the FDG uptake and the size of the mass.
  
  
  CONCLUSIONS
  Pre-treatment imaging features and post-treatment imaging characteristics of IMT correlate with clinical findings and suggest that FDG-PET/CT may be useful as an adjunct to clinical evaluation in monitoring of immunosuppressive therapy of IMT.
authors.affiliation: Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
authors.forename: Sebastian L
authors.initials: SL
authors.lastname: Obrzut
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Halpern
authors.forename: Travis
authors.initials: T
authors.lastname: Monchamp
authors.forename: Karsten
authors.initials: K
authors.lastname: Grabski
authors.forename: William J
authors.initials: WJ
authors.lastname: Watts
authors.forename: Johannes
authors.initials: J
authors.lastname: Czernin
mesh_terms: D005260:Female; D019788:Fluorodeoxyglucose F18; D006104:Granuloma, Plasma Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D007166:Immunosuppressive Agents; D019788:Fluorodeoxyglucose F18