title: Localised extranodal lymphoma of the head and neck: the Sheffield Lymphoma Group experience (1971-2000).
abstract: OBJECTIVE
  Over the 30-year period from 1971-2000, 3750 cases of lymphoma were referred to the Sheffield Lymphoma Group for investigation and treatment. Of these, 580 were extranodal presentations and, of these, 190 (33%) were localised to the head and neck region. The aim of this lymphoma database review was to evaluate the patient characteristics and survival rates for these patients.
  
  
  METHODS
  The sample included 98 women and 92 men, with a median age at presentation of 65 years.
  
  
  RESULTS
  The most common site affected was tonsil (34%), followed by salivary glands (16%). Other common sites were the thyroid, orbit and nasopharynx. The most frequent presenting feature was a swelling or mass, with pain, dysphagia and nasal obstruction also comprising large groups. All cases were non-Hodgkin's lymphoma. Fifty-five cases were histological grade 1; 132 were grade 2. Diffuse large B cell was the most common histological subtype. The overall 5- and 10-year survival rates were 55% (95% CI 47-62) and 44%, (95% CI 36-53), respectively, with a median survival of 92 months (95% CI 56-128). Stage and grade were both found to influence survival.
  
  
  CONCLUSIONS
  This data concords with and extends information available from previous studies. More detail is now required on specific head and neck sites.
authors.affiliation: YCR Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
authors.forename: S
authors.initials: S
authors.lastname: Hart
authors.forename: J M
authors.initials: JM
authors.lastname: Horsman
authors.forename: C R
authors.initials: CR
authors.lastname: Radstone
authors.forename: H
authors.initials: H
authors.lastname: Hancock
authors.forename: J R
authors.initials: JR
authors.lastname: Goepel
authors.forename: B W
authors.initials: BW
authors.lastname: Hancock
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis