Meperidine-induced seizure after revision hip arthroplasty.
Musculoskeletal injuries secondary to seizures are well documented and have a variable incidence. Meperidine (Demerol [Abbott, Abbott Park, IL]) has been used for many years in the postoperative setting for pain control; however, in high doses, it has been associated with seizure. We report the case of patient who experienced a tonic-clonic seizure 5 days after hip revision surgery, resulting in dissociation of the socket from the acetabulum with an associated acetabular fracture. In this patient, meperidine administered for patient-controlled analgesia within recommended range caused the seizure.
Beaulé
Paul E
PE
David Geffen School of Medicine at the University of California Los Angeles, 90017, USA.
Smith
M Iain
MI
Nguyen
Vinh N
VN
D000077:Acetabulum / Q000293:injuries*; D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D006617:Hip Dislocation / Q000209:etiology; D006801:Humans; D008614:Meperidine / Q000009:adverse effects*; D010146:Pain / Q000188:drug therapy; D012086:Reoperation; D012640:Seizures / Q000139:chemically induced* / Q000150:complications
D000700:Analgesics; D008614:Meperidine