title: Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells.
abstract: Identification of biomaterials that support appropriate cellular attachment, proliferation and gene expression patterns is critical for tissue engineering and cell therapy. Here we describe an approach for rapid, nanoliter-scale synthesis of biomaterials and characterization of their interactions with cells. We simultaneously characterize over 1,700 human embryonic stem cell-material interactions and identify a host of unexpected materials effects that offer new levels of control over human embryonic stem cell behavior.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Anderson
authors.forename: Shulamit
authors.initials: S
authors.lastname: Levenberg
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004622:Embryo, Mammalian / Q000166:cytology*; D006801:Humans; D046228:Microarray Analysis / Q000379:methods*; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology; D013234:Stem Cells / Q000187:drug effects* / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D011108:Polymers