title: A novel method for the preparation of nucleoside triphosphates from activated nucleoside phosphoramidates.
abstract: [reaction: see text] A novel method for the preparation of nucleoside triphosphates has been developed. The strategy employs a highly reactive pyrrolidinium phosphoramidate zwitterion intermediate that undergoes efficient coupling with tris(tetra-n-butylammonium) hydrogen pyrophosphate to generate nucleoside triphosphate.
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology and Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Weidong
authors.initials: W
authors.lastname: Wu
authors.forename: Caren L
authors.initials: CL
authors.lastname: Freel Meyers
authors.forename: Richard F
authors.initials: RF
authors.lastname: Borch
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D011756:Diphosphates / Q000737:chemistry; D009711:Nucleotides / Q000138:chemical synthesis*; D010756:Phosphoric Acids / Q000138:chemical synthesis / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry; D013936:Thymidine / Q000737:chemistry; D013942:Thymine Nucleotides / Q000737:chemistry
chemical_list: D000577:Amides; D011756:Diphosphates; D009711:Nucleotides; D010756:Phosphoric Acids; D011759:Pyrrolidines; D013942:Thymine Nucleotides; C011067:phosphoramidic acid; D013936:Thymidine