title: Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi.
abstract: We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity.
authors.affiliation: Universidade Federal Rural do Rio de Janeiro, Instituto de Ciências Exatas, Departamento de Química, Km 7, BR 465 CEP: 23.890-000, Seropédica, RJ Brazil.
authors.forename: Tatiana Santana
authors.initials: TS
authors.lastname: Ribeiro
authors.forename: Leonardo
authors.initials: L
authors.lastname: Freire-de-Lima
authors.forename: José Osvaldo
authors.initials: JO
authors.lastname: Previato
authors.forename: Lucia
authors.initials: L
authors.lastname: Mendonça-Previato
authors.forename: Norton
authors.initials: N
authors.lastname: Heise
authors.forename: Marco Edilson Freire
authors.initials: ME
authors.lastname: de Lima
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D052117:Benzodioxoles; D002478:Cells, Cultured; D014355:Chagas Disease / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D020128:Inhibitory Concentration 50; D021261:Parasitic Sensitivity Tests; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D014344:Trypanocidal Agents; C008922:piperine