[Aging rate after continual low dose irradiation of drosophila strains with apoptosis deregulation].
In this article the results of investigations of interrelation between radio-induced apoptosis in larvae nervous system and aging in imago are presented. It was shown that the apoptosis level of larvae nervous ganglion 2.5 folds increased after exposure to ionizing radiation (54 cGy). Irradiation of stocks with higher apoptosis induction sensitivity, bearing mutations of inhibitor apoptosis protein th (allele th1 and th4) and wild type strain Berlin leaded to elevation of activity at all ages and accordingly to decreasing of aging speed. Whereas in stocks with lower apoptosis induction sensitivity (with mutations of genes rpr, grim, hid, dArk and Dcp-1) this effect was not observed. The obtained results suggested that radiation-induced apoptosis could be one of the mechanisms preventing aging.
Moskalev
A A
AA
Institute of Biology, Komi Science Center of Russian Academy of Science, Syktyvkar, 167983 Russia. amoskalev@ib.komisc.ru
Zaĭnullin
V G
VG
D000375:Aging / Q000528:radiation effects*; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology / Q000528:radiation effects*; D005724:Ganglia / Q000473:pathology / Q000528:radiation effects; D007814:Larva / Q000528:radiation effects; D009154:Mutation; D009479:Neuropeptides / Q000235:genetics
D029721:Drosophila Proteins; C108880:HID protein, Drosophila; D009479:Neuropeptides; C400550:dark protein, Drosophila; C108881:grim protein, Drosophila; C086973:rpr protein, Drosophila; D020169:Caspases; C103568:Dcp-1 protein, Drosophila