Closing the loop: the adicol experience.
The objective of the project Advanced Insulin Infusion using a Control Loop (ADICOL) was to develop a treatment system that continuously measures and controls the glucose concentration in subjects with type 1 diabetes. The modular concept of the ADICOL's extracorporeal artificial pancreas consisted of a minimally invasive subcutaneous glucose system, a handheld PocketPC computer, and an insulin pump (D-Tron, Disetronic, Burgdorf, Switzerland) delivering subcutaneously insulin lispro. The present paper describes a subset of ADICOL activities focusing on the development of a glucose controller for semi-closed-loop control, an in silico testing environment, clinical testing, and system integration. An incremental approach was adopted to evaluate experimentally a model predictive glucose controller. A feasibility study was followed by efficacy studies of increasing complexity. The ADICOL project demonstrated feasibility of a semi-closed-loop glucose control during fasting and fed conditions with a wearable, modular extracorporeal artificial pancreas.
Hovorka
Roman
R
Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom. r.hovorka@uk.avecho.com
Chassin
Ludovic J
LJ
Wilinska
Malgorzata E
ME
Canonico
Valentina
V
Akwi
Joyce Akwe
JA
Federici
Marco Orsini
MO
Massi-Benedetti
Massimo
M
Hutzli
Ivo
I
Zaugg
Claudio
C
Kaufmann
Heiner
H
Both
Marcel
M
Vering
Thomas
T
Schaller
Helga C
HC
Schaupp
Lukas
L
Bodenlenz
Manfred
M
Pieber
Thomas R
TR
D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy*; D004867:Equipment Design; D006801:Humans; D007332:Insulin Infusion Systems; D018670:Monitoring, Ambulatory / Q000295:instrumentation / Q000379:methods
D001786:Blood Glucose