title: Detection and quantification limits: basic concepts, international harmonization, and outstanding ("low-level") issues.
abstract: A brief review is given of concepts, basic definitions, and terminology for metrological detection and quantification capabilities, representing harmonized recommendations and norms of the International Union of Pure and Applied Chemistry (IUPAC) and the International Organization for Standardization (ISO), respectively. Treatment of the (low-level) blank and variance function are discussed in some detail, together with special problems arising with detection decisions and the reporting of low-level data. Key references to the international documents follow, as well as specialized references addressing very low-level counting data, skewed environmental blank distributions, and multiple and multivariate detection decisions.
authors.affiliation: Chemical Science/Technical Laboratory, National Institute of Standards and Technology, Stop 8370, Gaithersburg, MD 20899-8370, USA. lloyd.currie@nist.gov
authors.forename: L A
authors.initials: LA
authors.lastname: Currie