Effect of sodium molybdate on the status of lipids, lipid peroxidation and antioxidant systems in alloxan-induced diabetic rats.
BACKGROUND
Diabetes mellitus manifests itself in a wide variety of complications and the symptoms of the disease are multi-factorial.


METHODS
The lipid peroxidation (LPO) and antioxidant status were investigated in hemolysate, liver and kidney in alloxan-induced diabetic rats and the effect of molybdate supplementation on antioxidant defense systems.


RESULTS
Diabetic rats exhibited an increase in the levels of lipids, lipid peroxidation and decrease in antioxidant status when compared to control rats. Oral administration of molybdate to diabetic rats for 30 days significantly reduced the levels of lipids like cholesterol, triglycerides, phospholipids and lipid peroxidation whereas increased the activities of antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH).


CONCLUSIONS
Molybdate prevents oxidation of lipids and protects antioxidant systems in experimental diabetic rats, and thus, may be useful for the prevention or early treatment of diabetic mellitus.
Panneerselvam
Saraswathi R
SR
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai-600 025, India. panneerselvam@eth.net
Govindasamy
Swaminathan
S
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D010743:Phospholipids / Q000097:blood; D051381:Rats; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D008982:Molybdenum; C024687:sodium molybdate(VI); D002784:Cholesterol