title: [Expression of pepsinogen C in gastric cancer and its precursor].
abstract: OBJECTIVE
  To investigate the dynamic expression of pepsinogen C (PGC) and its value in detection of precursor and gastric cancer.
  
  
  METHODS
  Immunohistochemistry was used to examine the expression of PGC in 424 biopsy specimens of stomach mucosa collected by gastroscopy.
  
  
  RESULTS
  The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100% and 2.4% in 124 cases of gastric cancer. The positive rate of PGC expression decreased in the order of superficial gastritis/gastric ulcer or erosion-->atrophic gastritis or gastric dysplasia-->gastric cancer (P < 0.01).
  
  
  CONCLUSIONS
  The expression of PGC is negatively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. PGC has high sensitivity and specificity in diagnosis of precursor of gastric cancer and can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer.
authors.affiliation: Cancer Institute of the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
authors.forename: Pei-fang
authors.initials: PF
authors.lastname: Ning
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Sun
authors.forename: Hui-jie
authors.initials: HJ
authors.lastname: Liu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yuan
mesh_terms: D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology*; D005756:Gastritis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D020115:Pepsinogen C / Q000032:analysis*; D010437:Peptic Ulcer / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D020115:Pepsinogen C