Effect of ultrasound on acute inflammation of transected medial collateral ligaments.
OBJECTIVE
To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue injuries by measuring the levels of prostaglandin E(2) (PGE(2)) and leukotriene B(4) (LTB(4)).


METHODS
Randomized, case-control study.


METHODS
Laboratory animal facility.


METHODS
Thirty 3-month-old male Sprague-Dawley rats.


METHODS
Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5, 1.5, 2.3W/cm(2)).


METHODS
Levels of PGE(2) and LTB(4).


RESULTS
The levels of PGE(2) and LTB(4) were higher in all intensity subgroups that received 2.3W/cm(2) intensity on postinjury day 2. On postinjury day 11, LTB(4) was significantly decreased, but PGE(2) was significantly increased.


CONCLUSIONS
Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.
Leung
Mason C
MC
Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China. rsmcpleung@inet.polyu.edu.hk
Ng
Gabriel Y
GY
Yip
K K
KK
D000704:Analysis of Variance; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D007249:Inflammation / Q000378:metabolism / Q000628:therapy*; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D017888:Medial Collateral Ligament, Knee / Q000293:injuries* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014464:Ultrasonic Therapy
D007975:Leukotriene B4; D015232:Dinoprostone