Four new andrographolide metabolites in human urine.
Andrographolide is one of principal components of a famous traditional Chinese herbal medicine Andrographis paniculate (BURM) NEES. Four new metabolites of andrographolide were isolated from human urine. All of them were characterized as sulfate and one of them also as a cysteine S-conjugate. The structures were determined to be andrographolide-3-O-sulfate (M-1), isoandrographolide-3-O-sulfate (M-2), 14-deoxyandrographolide-3-O-sulfate (M-3), 14-deoxy-12-(cysteine-S-yl)-andrographolide-3-O-sulfate (M-4), respectively, based on chemical evidence and spectroscopic analyses.
Cui
Liang
L
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, P.R. China 110-016.
Qiu
Feng
F
Wang
Naili
N
Yao
Xinsheng
X
D000328:Adult; D004224:Diterpenes / Q000737:chemistry* / Q000378:metabolism / Q000652:urine*; D006801:Humans; D008297:Male
D004224:Diterpenes; C030419:andrographolide