title: A novel and highly efficient synthetic route to unsymmetrical organoselenides using cesium bases.
abstract: A new and convenient one-pot method for the preparation of unsymmetrical selenides has been developed. In the presence of cesium hydroxide, molecular sieves, and DMF, benzeneselenol undergoes direct alkylation with various alkyl halides for the synthesis of alkyl phenyl selenides in moderate to excellent yields. Another method to prepare unsymmetrical organoselenides was also completed by coupling terminal alkynes with benzeneselenyl bromide. As an application, the synthesis of a selenopeptide was also accomplished. Furthermore, this methodology was extended to the synthesis of an organoselenide on solid support.
authors.affiliation: Department of Chemistry, Western Kentucky University, 1 Big Red Way, Bowling Green, Kentucky 42101-3576, USA.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Cohen
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Fox
authors.forename: Ralph Nicholas
authors.initials: RN
authors.lastname: Salvatore