title: Fine mapping of milk production QTL on BTA6 by combined linkage and linkage disequilibrium analysis.
abstract: Combined linkage and linkage disequilibrium analysis were used to refine the position of a previously detected QTL affecting milk production traits on bovine chromosome 6. Through a series of single- and multitrait and single- and multipoint QTL analyses, the QTL could be positioned to a 7.5-cM interval surrounded by the markers BMS2508 and FBN12. The most significant results were found for fat percentage and protein percentage. This effect seemed to be caused by a QTL allele embedded in one specific marker haplotype that caused a reduction in fat and protein yields and a concomitant increase of milk yield, thus resulting in a marked reduction of fat and protein percentages.
authors.affiliation: Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N-1432 Aas, Norway. hanne-gro.olsen@iha.nlh.no
authors.forename: H G
authors.initials: HG
authors.lastname: Olsen
authors.forename: S
authors.initials: S
authors.lastname: Lien
authors.forename: M
authors.initials: M
authors.lastname: Svendsen
authors.forename: H
authors.initials: H
authors.lastname: Nilsen
authors.forename: A
authors.initials: A
authors.lastname: Roseth
authors.forename: M
authors.initials: M
authors.lastname: Aasland Opsal
authors.forename: T H E
authors.initials: TH
authors.lastname: Meuwissen
mesh_terms: D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006239:Haplotypes; D007774:Lactation / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics*; D008055:Lipids / Q000032:analysis; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins / Q000032:analysis; D040641:Quantitative Trait Loci / Q000235:genetics*
chemical_list: D008055:Lipids; D008894:Milk Proteins