title: Non-Hodgkin's lymphoma among asthmatics exposed to pesticides.
abstract: We conducted a pooled analysis of population-based case-control studies in Iowa, Minnesota and Nebraska to investigate whether asthma modifies risk of non-Hodgkin's lymphoma (NHL) associated with pesticide exposures. Cases (n = 872) diagnosed with NHL from 1980 to 1986 and frequency-matched controls (n = 2,381) randomly selected from the same geographic areas as the cases were included. Information on use of pesticides and history of asthma was based on interviews. Unconditional logistic regression was used to calculate ORs, adjusted for age, state and vital status. Of all subjects, 177 (45 cases, 132 controls) reported having been told by their doctor that they had asthma. Subjects with an asthma history had a nonsignificantly lower risk of NHL than nonasthmatics (OR = 0.6, 95% CI 0.3-1.4), and there was no main effect of pesticide exposure (OR = 1.0, 95% CI 0.8-1.2). However, asthmatics tended to have larger ORs associated with exposure to pesticides than nonasthmatics. The OR among asthmatics was 1.8 (95% CI 1.1-3.2) for ever-use of crop insecticides, 2.7 (95% CI 1.0-7.2) for chlordane, 2.4 (95% CI 1.0-5.7) for lindane and 3.7 (95% CI 1.3-10.9) for fonofos. Among nonasthmatics, ORs were 1.1 (0.9-1.3), 1.5 (1.1-2.2), 1.3 (0.97-1.8) and 1.6 (1.0-2.4), respectively. Although there is limited power for assessing interaction, our results suggest that the risk of NHL among asthmatics with pesticide exposure may be higher than among nonasthmatics with pesticide exposure.
authors.affiliation: Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Leewj@mail.nih.gov
authors.forename: Won Jin
authors.initials: WJ
authors.lastname: Lee
authors.forename: Kenneth P
authors.initials: KP
authors.lastname: Cantor
authors.forename: Jay A
authors.initials: JA
authors.lastname: Berzofsky
authors.forename: Shelia H
authors.initials: SH
authors.lastname: Zahm
authors.forename: Aaron
authors.initials: A
authors.lastname: Blair
mesh_terms: D000368:Aged; D001249:Asthma / Q000150:complications*; D016022:Case-Control Studies; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000506:poisoning*; D005260:Female; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009329:Nebraska / Q000453:epidemiology; D016017:Odds Ratio; D010575:Pesticides / Q000506:poisoning*; D018570:Risk Assessment
chemical_list: D004785:Environmental Pollutants; D010575:Pesticides