title: 6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.
abstract: A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure-activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed.
authors.affiliation: College of Pharmacy, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, South Korea.
authors.forename: Hyen Joo
authors.initials: HJ
authors.lastname: Park
authors.forename: Young-Shin
authors.initials: YS
authors.lastname: Kim
authors.forename: Jin Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Lee
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Yi
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Hwang
authors.forename: Myung-Eun
authors.initials: ME
authors.lastname: Suh
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D026942:DNA Topoisomerases / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059003:Topoisomerase Inhibitors
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011799:Quinazolines; D059003:Topoisomerase Inhibitors; D026942:DNA Topoisomerases