Libraries from natural product-like scaffolds.
Natural products are an attractive source of varied structures that exhibit potent biological activities, and desirable pharmacological profiles. Since the relatively recent advent of high-throughput organic synthesis in the drug discovery process, several design approaches have been applied to the construction of screening libraries. Libraries of natural-product derivatives, natural-product-like compounds prepared by total synthesis, and libraries derived from natural-products are several types that have been reported.
Boldi
Armen M
AM
Discovery Partners International, Discovery Chemistry Division, 385 Oyster Pt Blvd, Suite 1, South San Francisco, California 94080 USA. boldi@chemrx.com
D001685:Biological Factors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D007990:Libraries; D015394:Molecular Structure
D001685:Biological Factors