Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population.
OBJECTIVE
To determine whether polymorphisms in the estrogen receptor (ER) alpha and beta genes are associated with endometriosis in a Japanese population.


METHODS
Association study.


METHODS
University hospital.


METHODS
Japanese women diagnosed with endometriosis by laparotomy or laparoscopy.


METHODS
Determination of polymorphisms in the ERalpha and ERbeta genes was performed by polymerase chain reaction restriction fragment-length polymorphism analysis in 132 affected women and 182 controls.


METHODS
Frequency and distribution of AluI and RsaI polymorphisms in ERbeta gene and of PvuII and XbaI polymorphisms in ERalpha gene.


RESULTS
No significant differences in the frequency of either AluI and RsaI polymorphisms in the ERbeta gene or of XbaI and PvuII polymorphisms in the ERalpha gene were found between endometriosis patients and controls. However, a positive association was noted between the AluI polymorphism in the ERbeta gene and stage IV endometriosis patients in the population studied.


CONCLUSIONS
The AluI polymorphism in the ERbeta gene is associated with an increased risk of stage IV endometriosis in a Japanese population.
Wang
Zhuo
Z
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoshida
Shigeki
S
Negoro
Kenichi
K
Kennedy
Stephen
S
Barlow
David
D
Maruo
Takeshi
T
D044466:Asian People / Q000235:genetics*; D004715:Endometriosis / Q000235:genetics* / Q000473:pathology; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011960:Receptors, Estrogen / Q000235:genetics*
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen