title: [Influence of chronic epilepsy on spatial memory retrieval in rats].
abstract: To investigate the influence of chronic epilepsy on spatial memory retrieval in rats, and to evaluate the effects of TAK-147, an acetylcholinesterase inhibitor, and histidine, the precursor of histamine, on the amnesia induced by epilepsy.
  
  
  
  After successfully trained in the 8-arm (4-arm baited) radial maze, the rats were ip injected with a subconvulsive dose of pentylenetetrazole (PTZ) every 48 h until fully kindled. Memory retrieval was tested at the same maze.
  
  
  
  Impairment of memory retrieval was in a steady state 1 to 18 days after fully kindled, the ability of memory retrieval returned to the control level 31 days after fully kindled. TAK-147 showed an ameliorating effect on memory impairment induced by epilepsy, including reference and working memory in a dose-dependent manner. Histidine only ameliorated reference but not working memory.
  
  
  
  PTZ-kindled seizure impair spatial memory retrieval, which it might be due to a decrease of brain acetylcholine and histamine induced by epilepsy.
authors.affiliation: Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
authors.forename: Li-san
authors.initials: LS
authors.lastname: Zhang
authors.forename: Chu-lei
authors.initials: CL
authors.lastname: Jin
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Yong-cheng
authors.initials: YC
authors.lastname: Sun
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000627:therapeutic use; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000523:psychology*; D008297:Male; D018782:Maze Learning; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology*; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001552:Benzazepines; C099872:TAK 147; D010433:Pentylenetetrazole