title: [A study of the relationship between initial febrile seizures and human herpes virus 6, 7 infections].
abstract: The DNA detection of human herpes virus (HHV) 6, 7 was performed in the patients who visited to the Nakano children's hospital because of their initial febrile seizures (FS). Those patients included 35 boys and 21 girls under 3 years of age (mean: 1 year 4 months). DNAs of HHV 6, 7 in the mononuclear cells extracted from peripheral blood were detected in 84% of the patients. This study proved that at least 34% of initial FS are caused by HHV 6 or 7 infections. Forty-seven percents of the patients who were clinically diagnosed as exanthema subitum showed complex type FS. In conclusion, HHV 6 and 7 infections are often related to the occurrence of initial FS, which may be in part caused by their direct invasion to the central nervous system.
authors.affiliation: The Nakano Children's Hospital, Osaka. kiyo@pearl.ocn.ne.jp
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Murakami
mesh_terms: D002675:Child, Preschool; D004279:DNA, Viral / Q000302:isolation & purification*; D005077:Exanthema Subitum / Q000150:complications* / Q000821:virology; D005260:Female; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000472:pathogenicity*; D016199:Herpesvirus 7, Human / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D007223:Infant; D008297:Male; D003294:Seizures, Febrile / Q000209:etiology*
chemical_list: D004279:DNA, Viral