Effect of shape of sodium salicylate particles on physical property and in vitro aerosol performance of granules prepared by pressure swing granulation method.
The purpose of this research was to investigate the effect of the shape of sodium salicylate (SS) particles on the physical properties as well as the in vitro aerosol performance of the granules granulated by the pressure swing granulation method. SS was pulverized with a jet mill (JM) to prepare the distorted particles, and SS aqueous solution was spray dried (SD) to prepare the nearly spherical particles. The particle size distribution, crushing strength, and pore size distribution of the granules were measured. The adhesive force of the primary particles in the granules was calculated according to Rumpf's equation. The in vitro aerosol performance of the granules was evaluated using a cascade impactor. Both JM and SD particles can be spherically granulated by the pressure swing granulation method without the use of a binder. The size of SD granules was smaller than that of JM granules. Although the crushing strength of the JM and SD granules is almost the same, the internal structures of JM granules and SD granules were found to differ, and the SD particles appear to have been condensed uniformly, resulting in a nearly spherical shape. In the inhalation investigation, the percentage of SS particles of appropriate size delivered to the region for treatment was noticeably higher for SD granules than for JM granules. This finding might be because the adhesive force of the SD primary particles was smaller than that of the JM primary particles in the granules and because the SD granules could be easily separated by air current to obtain the primary particles.
Watanabe
Masayuki
M
Department of Pharmaceutics and Drug Delivery, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji 192-0392, Japan.
Ozeki
Tetsuya
T
Shibata
Tomoko
T
Murakoshi
Hayato
H
Takashima
Yuuki
Y
Yuasa
Hiroshi
H
Okada
Hiroaki
H
D000336:Aerosols / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D010316:Particle Size; D011208:Powders / Q000737:chemistry*; D011312:Pressure; D012980:Sodium Salicylate / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D000267:Tissue Adhesions
D000336:Aerosols; D011208:Powders; D012980:Sodium Salicylate