title: Preparation of poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels and their drug release behavior.
abstract: N-isopropylacrylamide/itaconic acid copolymeric hydrogels were prepared by irradiation of the ternary mixtures of N-isopropylacrylamide/itaconic acid/water by gamma-rays at ambient temperature. The effect of comonomer concentration, irradiation dose and pH on the swelling equilibria were studied. Lidocaine was used as a model drug for the investigation of drug release behaviour of hydrogels. Lidocaine adsorption capacity of the hydrogels were found to increase from 3.6 to 862.1 (mg lidocaine/g dry gel) with increasing amount of itaconic acid in the gel structure. Adsorption and release processes were followed at 4 and 37 degrees C, respectively. The release studies showed that the basic parameters affecting the drug release behaviour of the hydrogels were pH and temperature of the solution and cross-link density of the gels.
authors.affiliation: Chemistry Department, Cekmece Nuclear Research and Training Center, 34831, P.O. Box 1, Istanbul, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Taşdelen
authors.forename: Nilhan
authors.initials: N
authors.lastname: Kayaman-Apohan
authors.forename: Olgun
authors.initials: O
authors.lastname: Güven
authors.forename: Bahattin M
authors.initials: BM
authors.lastname: Baysal
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000327:Adsorption; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000737:chemistry; D005720:Gamma Rays; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008012:Lidocaine / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013386:Succinates / Q000737:chemistry; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D000779:Anesthetics, Local; D020100:Hydrogels; D013386:Succinates; C052970:poly-N-isopropylacrylamide; D008012:Lidocaine; C005229:itaconic acid