title: Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide.
abstract: Eosinophilic cystitis is a rare and poorly understood disorder. We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis. The patient presented with severe bladder pain, fever, and eosinophilia several hours after instillation. These symptoms were unresponsive to conventional analgesic and antibiotic treatments. Cystoscopy revealed erythema and exudate at the bladder walls, along with edema of both ureteral orifices. Bladder biopsies demonstrated massive eosinophilic infiltration of the bladder, confirming the diagnosis of eosinophilic cystitis. Urologists should bear in mind this clinical entity, particularly when DMSO is administered to patients with multiple drug allergies.
authors.affiliation: Division of Urogynecology and Reconstructive Pelvic Surgery, Evanston Continence Center, Evanston, Illinois 60201, USA.
authors.forename: Yoram
authors.initials: Y
authors.lastname: Abramov
authors.forename: Roger P
authors.initials: RP
authors.lastname: Goldberg
authors.forename: Michael
authors.initials: M
authors.lastname: McGuire
authors.forename: Barbara
authors.initials: B
authors.lastname: Golden
authors.forename: Sanjay
authors.initials: S
authors.lastname: Gandhi
authors.forename: Peter K
authors.initials: PK
authors.lastname: Sand
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000283:Administration, Intravesical; D003556:Cystitis / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003558:Cystoscopy; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D014549:Urinary Incontinence / Q000209:etiology; D014555:Urination Disorders / Q000209:etiology
chemical_list: D004121:Dimethyl Sulfoxide