title: Synthesis, complete characterization, and enantioselective electrokinetic separation of functionalized ruthenium complex enantiomers.
abstract: Electrokinetic chromatography was employed to separate the enantiomers of two novel functionalized ruthenium(II) complexes with different polypyridyl coordination spheres. The use of anionic carboxymethyl-beta-cyclodextrin as chiral mobile phase additive resulted in maximum efficiency and resolution for the enantiomer separation of both transition metal complexes. The syntheses of the [4-(3-hydroxypropyl)-4'-methyl-2,2'-bipyridine]-bis(2,2'-bipyridine)rethenium(II)-bis(tetrafluoroborate) and [4-(3-hydroxypropyl)-4'-methyl-2,2'-bipyridine]-bis(4,4'-dimethyl-2,2'-bypyridine)ruthenium(II)-bis(tetrafluoroborate) complexes and their complete characterization by means of two-dimensional (1)H and (13)C[(1)H] NMR techniques ((1)H-(1)H COSY and (1)H-(13)C HMQC) as well as elemental analyses and MALDI-TOFMS are described in detail. The functionalized complexes can be used as building blocks for further reactions with polymers, biopolymers, surfaces and nanoparticles.
authors.affiliation: Laboratory of Macromolecular Chemistry and Nanoscience, Eindhoven University of Technology and Dutch Polymer Institute, Eindhoven, The Netherlands.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Holder
authors.forename: Oliver
authors.initials: O
authors.lastname: Trapp
authors.forename: Gabriele
authors.initials: G
authors.lastname: Trapp
authors.forename: Veronica
authors.initials: V
authors.lastname: Marin
authors.forename: Richard
authors.initials: R
authors.lastname: Hoogenboom
authors.forename: Ulrich S
authors.initials: US
authors.lastname: Schubert
mesh_terms: D002621:Chemistry / Q000379:methods*; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D012428:Ruthenium / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013237:Stereoisomerism; D013997:Time Factors; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D017975:Ruthenium Compounds; D047392:beta-Cyclodextrins; C441457:carboxymethyl-beta-cyclodextrin; D012428:Ruthenium