Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide.
In view of biological activities of azole nucleosides and apio-dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3-O-isopropylidene-apio-beta-D-furanose (3), which was prepared from D-mannose.
Kim
Myong Jung
MJ
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.
Jeong
Lak Shin
LS
Kim
Joong Hyup
JH
Shin
Ji Hye
JH
Chung
Soon Yong
SY
Lee
Sang Kook
SK
Chun
Moon Woo
MW
D008358:Mannose / Q000031:analogs & derivatives* / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D009705:Nucleosides; D013844:Thiazoles; D014230:Triazoles; D008358:Mannose