title: Improvement of dyslipidemia in patients switching from stavudine to tenofovir: preliminary results.
abstract: In a prospective, multicentre, switch study to identify the most frequently occurring nucleoside reverse transcriptase inhibitor (NRTI)-associated toxicities that cause NRTI withdrawal in virologically suppressed HIV-infected patients, among those who underwent stavudine substitution by tenofovir, 271 had hypertriglyceridemia and 193 had hypercholesterolemia. After 12 weeks of switching from stavudine to tenofovir, triglyceride and cholesterol levels showed significant de-creases, which suggests that such a switch may reverse, at least partly, stavudine-associated dyslipidaemia.
authors.forename: Pere
authors.initials: P
authors.lastname: Domingo
authors.forename: Pablo
authors.initials: P
authors.lastname: Labarga
authors.forename: Rosario
authors.initials: R
authors.lastname: Palacios
authors.forename: Manuel Fernández
authors.initials: MF
authors.lastname: Guerro
authors.forename: José Alberto
authors.initials: JA
authors.lastname: Terrón
authors.forename: María J
authors.initials: MJ
authors.lastname: Elías
authors.forename: Jesús
authors.initials: J
authors.lastname: Santos
authors.forename: María I
authors.initials: MI
authors.lastname: Ruiz
authors.forename: Josep M
authors.initials: JM
authors.lastname: Llibre
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D006949:Hyperlipidemias / Q000517:prevention & control*; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D011446:Prospective Studies; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D018119:Stavudine / Q000627:therapeutic use*; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D018119:Stavudine; D000225:Adenine