title: Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm.
abstract: The first time-resolved optical mammograph operating beyond 900 nm (683, 785, 913, and 975 nm) is presently being used in a clinical trial to test the diagnostic potential of the technique in detecting and characterizing breast lesions. Between November 2001 and October 2002, 101 patients with malignant and benign lesions were analyzed retrospectively. Scattering plots, as derived from a homogeneous model, and late gated intensity images, to monitor spatial changes in the absorption properties, are routinely used. The intensity images available at four wavelengths provide sensitivity to the main tissue constituents (oxy- and deoxyhemoglobin, water, and lipids), in agreement with expected tissue composition and physiology, while the scattering plots mirror structural changes. Briefly, tumors are usually identified due to the strong blood absorption at short wavelengths, cysts to the low scattering, and fibroadenomas to low absorption at 913 nm and high at 975 nm, even though the optical features of fibroadenomas seem not to be uniquely defined. The effectiveness of the technique in localizing and discriminating different lesion types is analyzed as a function of various parameters (lesion size, compressed breast thickness, and breast parenchymal pattern). .
authors.affiliation: Politecnico di Milano, INFM-Dipartimento di Fisica, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy. paola.taroni@fisi.polimi.it
authors.forename: Paola
authors.initials: P
authors.lastname: Taroni
authors.forename: Gianmaria
authors.initials: G
authors.lastname: Danesini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Torricelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Pifferi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spinelli
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Cubeddu
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D018226:Fibroadenoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D005348:Fibrocystic Breast Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D010363:Pattern Recognition, Automated; D011859:Radiography; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods*