title: Bupivacaine provides rapid, effective periprostatic anaesthesia for transrectal prostate biopsy.
abstract: OBJECTIVE
  To examine the effectiveness of the longer acting agent bupivacaine in providing periprostatic anaesthesia during transrectal ultrasonography (TRUS)-guided biopsy, as the periprostatic injection of lidocaine has been shown to significantly alleviate the pain of this procedure.
  
  
  METHODS
  Seventy-five patients were randomized to receive a periprostatic injection with either bupivacaine, a lidocaine/bupivacaine (1/1) combination, or no local anaesthesia. Immediately before biopsy 5 mL of the anaesthetic was injected under TRUS guidance into the periprostatic nerves bilaterally. After taking a 10-core biopsy the patients were given a visual analogue scale (VAS; 0-10) to assess their pain during the procedure.
  
  
  RESULTS
  The mean VAS scores were 2.04 in the bupivacaine group and 4.46 in the control (no local anaesthetic) group (P < 0.001).
  
  
  CONCLUSIONS
  Bupivicaine provides significant, immediate periprostatic anaesthesia for TRUS biopsy.
authors.affiliation: Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Rabets
authors.forename: J S
authors.initials: JS
authors.lastname: Jones
authors.forename: A R
authors.initials: AR
authors.lastname: Patel
authors.forename: C D
authors.initials: CD
authors.lastname: Zippe
mesh_terms: D019162:Anesthetics, Combined; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001707:Biopsy, Needle / Q000379:methods; D002045:Bupivacaine / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control*; D011467:Prostate / Q000473:pathology*
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine