title: Some physical properties of tabletted seed of Garcinia kola (HECKEL).
abstract: The formulation of Garcinia kola seeds into tablet dosage form and evaluation of some physical properties of the tablets are presented. A chemical assay was conducted on the dry, powdered seeds as well as the crude aqueous extract of the seeds. The dry powdered seeds contain 0.003% of flavonoids while the crude extract contained 0.007% of flavonoids based on rutin used as the standard. The powdered material (50 mg) and crude extract (10 mg) were formulated into tablets using the wet granulation method. Named binders were evaluated in these formulations. The various tablet parameters were evaluated, namely: weight variation, thickness and diameter, hardness, friability, disintegration time, dissolution profile and content uniformity. The results indicated that the tablets had good disintegration time, dissolution and hardness/friability profiles. Tablets formulated with starch had the best disintegration properties but were consequently very friable. Tablets formulated from 10 mg of the crude extract needed a larger proportion of diluents, which affected the tablet properties.
authors.affiliation: Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka, Nigeria.
authors.forename: G C
authors.initials: GC
authors.lastname: Onunkwo
authors.forename: H C
authors.initials: HC
authors.lastname: Egeonu
authors.forename: M U
authors.initials: MU
authors.lastname: Adikwu
authors.forename: J E
authors.initials: JE
authors.lastname: Ojile
authors.forename: A K
authors.initials: AK
authors.lastname: Olowosulu
mesh_terms: D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D029763:Garcinia kola / Q000737:chemistry* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D012639:Seeds / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D013607:Tablets / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D013607:Tablets