Altered signaling triggered by ligation of the TCR/CD3 receptor in T lymphocytes from patients with systemic lupus erythematosus: the road from anergy to autoimmunity.
Some of the signaling phenotypic abnormalities observed in peripheral blood T cells from patients with systemic lupus erythematosus resemble those seen in cells anergized by stimulation through the TCR/CD3 complex, in the absence of costimulatory signals, or by stimulation with altered ligands. The potential association of this "anergic" phenotype and the triggering of autoimmune responses in human lupus is discussed.
Blasini
Ana M
AM
Centro Nacional de Enfermedades Reumaticas, Division of Rheumatology, Hospital Universitario de Caracas, and Universidad Central de Venezuela, Caracas, Venezuela.
Rodríguez
Martín A
MA
D015551:Autoimmunity; D017635:Clonal Anergy; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D021962:Membrane Microdomains / Q000502:physiology; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*
D017260:Receptor-CD3 Complex, Antigen, T-Cell