[Allelic distribution of the CYP1A1 in lung cancer patients, middle-aged tissue donors and in elderly people without cancer].
The genetic polymorphism of metabolizers of tobacco smoke carcinogens can influence individual susceptibility to lung cancer. The study was concerned with the Mspl-polymorphism of the CYP1A1 gene responsible for encoding aryl hydrocarbon hydroxylase. It also plays a role in the activation of polycyclic aromatic hydrocarbons (PAH). The CYP1A1 alleles and genotype distribution in 146 lung cancer patients was compared with that in 230 healthy donors. Another control group consisted of 259 "cancer-resistant" subjects, i.e. tumor-free smokers and non-smokers aged 75 and more. The CYP1A1 allele incidence (19%) in patients with squamous lung cancer was significantly higher than in the control cohorts (11%) which is consistent with the leading role of PAH in the etiology of this pathology.
Belogubova
E V
EV
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Togo
A V
AV
Suvorova
I K
IK
Karpova
M B
MB
Ulybina
Iu M
IuM
Zaĭtseva
O A
OA
Iatsuk
O S
OS
Shutkin
V A
VA
Riabokon'
S A
SA
Ievleva
A G
AG
Chekmarëva
E V
EV
Lemekhov
V G
VG
Koloskov
A V
AV
Kuchinskiĭ
A P
AP
Khanson
K P
KP
Imianitov
E N
EN
D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004789:Enzyme Activation / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012697:Serine Endopeptidases / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects; D014019:Tissue Donors
D008565:Membrane Proteins; D001189:Aryl Hydrocarbon Hydroxylases; D019363:Cytochrome P-450 CYP1A1; D012697:Serine Endopeptidases; C429035:TMPRSS13 protein, human