title: Regulation of involucrin gene expression.
abstract: The epidermis is a dynamic renewing structure that provides life-sustaining protection from the environment. The major cell type of the epidermis, the epidermal keratinocyte, undergoes a carefully choreographed program of differentiation. Alteration of these events results in a variety of debilitating and life-threatening diseases. Understanding how this process is regulated is an important current goal in biology. In this review, we summarize the literature regarding regulation of involucrin, an important marker gene that serves as a model for understanding the mechanisms that regulate the differentiation process. Current knowledge describing the role of transcription factors and signaling cascades in regulating involucrin gene expression are presented. These studies describe a signaling cascade that includes the novel protein kinase C isoforms, Ras, MEKK1, MEK3, and a p38delta-extracellular signal regulated kinase 1/2 complex. This cascade regulates activator protein one, Sp1, and CCATT/enhancer-binding protein transcription factor DNA binding to two discrete involucrin promoter regions, the distal- and proximal-regulatory regions, to regulate involucrin gene expression.
authors.affiliation: Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. rle2@po.cwru.edu
authors.forename: Richard L
authors.initials: RL
authors.lastname: Eckert
authors.forename: James F
authors.initials: JF
authors.lastname: Crish
authors.forename: Tatiana
authors.initials: T
authors.lastname: Efimova
authors.forename: Shervin R
authors.initials: SR
authors.lastname: Dashti
authors.forename: Anne
authors.initials: A
authors.lastname: Deucher
authors.forename: Frederic
authors.initials: F
authors.lastname: Bone
authors.forename: Gautam
authors.initials: G
authors.lastname: Adhikary
authors.forename: Guosheng
authors.initials: G
authors.lastname: Huang
authors.forename: Ramamurthy
authors.initials: R
authors.lastname: Gopalakrishnan
authors.forename: Sivaprakasam
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000502:physiology*; D011498:Protein Precursors / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011498:Protein Precursors; C032253:involucrin