title: Successful ovariectomy in a dog with Glanzmann thrombasthenia.
abstract: Ovariectomy was performed in a 7-month-old Great Pyrenees with a severe congenital bleeding disorder. A diagnosis of Glanzmann thrombasthenia, a rare, congenital bleeding disorder characterized by a functional platelet defect, was later confirmed by isolation of genomic DNA from blood and amplification of exon 13 and intron 13 of the gene encoding for platelet glycoprotein subunit alphaIIb. Perioperative management consisted of administration of platelet-rich plasma prior to surgery and the use of high-frequency electrocoagulation to minimize tissue trauma. In addition, ovariectomy, rather than ovariohysterectomy, was performed to minimize surgical exposure required and manipulation of the urogenital tract. Results in this dog suggest that a combination of preoperative transfusion with functional platelets and use of techniques to minimize tissue trauma may allow abdominal surgery to be performed successfully in dogs with functional platelet disorders.
authors.affiliation: Department of Small Animal Clinical Sciences, Veterinary Medical Teaching Hospital, University of Florida, Gainesville, FL 32610-0126, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Brdecka
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Adin
authors.forename: Mary K
authors.initials: MK
authors.lastname: Boudreaux
authors.forename: E Cynda
authors.initials: EC
authors.lastname: Crawford
authors.forename: Stacy R
authors.initials: SR
authors.lastname: Randall
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D004285:Dogs / Q000601:surgery*; D004564:Electrocoagulation / Q000662:veterinary; D005260:Female; D010052:Ovariectomy / Q000662:veterinary*; D019990:Perioperative Care / Q000662:veterinary; D010974:Platelet Aggregation; D017713:Platelet Transfusion / Q000379:methods / Q000662:veterinary*; D019106:Postoperative Hemorrhage / Q000517:prevention & control / Q000662:veterinary; D011300:Preoperative Care / Q000662:veterinary; D013915:Thrombasthenia / Q000235:genetics / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D016896:Treatment Outcome