Identification of a novel HLA-DRB1 allele (DRB1*1147)* by sequence-based typing in eight siblings.
We report here a novel DRB1 allele (DRB1*1147) identified by sequence-based typing. The DRB1*1147 allele was detected during routine human leukocyte antigen (HLA)-typing of a patient and his family prior to bone marrow transplantation. This allele was found in the patient and his two sisters and five brothers. The new allele is identical to DRB1*110601 at exon 2 except for a single-nucleotide substitution at codon 37 (TAC-->TCC), changing the encoded tyrosine to serine.
Li
Y
Y
Guangzhou Cord Blood Bank, Guangzhou Maternal and Neonatal Hospital, Guangzhou, China. firefly@21cn.com
Liao
C
C
Yang
X
X
Tang
X-W
XW
Wu
J-Y
JY
Huang
Y-N
YN
Xie
X-M
XM
D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012689:Sequence Homology, Nucleic Acid; D035781:Siblings
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA