Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection.
We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.
Gaudy
Catherine
C
Laboratoire de Virologie, CHU Bretonneau, 37044 Tours Cedex, France.
Moreau
Alain
A
Brunet
Sylvie
S
Descamps
Jean-Michel
JM
Deleplanque
Pascale
P
Brand
Denys
D
Barin
Francis
F
D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000821:virology; D000328:Adult; D000595:Amino Acid Sequence; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation
D015483:HIV Antibodies