Molecular modeling on DNA cleavage activity of seryl-histidine and related dipeptide.
Molecular interaction between seryl-histidine (or seryl-histidine related dipeptides) and DNA model molecule 5'-TpTpdC-3' was studied by a molecular docking procedure. The key structural features of DNA cleaving activity were investigated.
Sun
Ming
M
The Key Laboratory of Bioorganic Phosphorous Chemistry, Ministry of Education, China, Department of Chemistry, Tsinghua University, Beijing 100084, China. sunm@sun5.ibp.ac.cn
Ma
Yuan
Y
Ji
Sanhao
S
Liu
Huanai
H
Zhao
Yufen
Y
D001665:Binding Sites; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D004151:Dipeptides / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D013816:Thermodynamics
D004151:Dipeptides; C422849:seryl-histidine; D004247:DNA