Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.
Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.
Bhaskaran
Krishnan
K
Medical Research Council Clinical Trials Unit, London, UK.
Pillay
Deenan
D
Walker
A Sarah
AS
Fisher
Martin
M
Hawkins
David
D
Gilson
Richard
R
McLean
Ken
K
Porter
Kholoud
K
D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D015331:Cohort Studies; D024882:Drug Resistance, Viral / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D008231:Lymphopenia / Q000821:virology; D008297:Male