title: Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents.
abstract: Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.
authors.affiliation: Valeant Pharmaceuticals International, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA.
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Smith
authors.forename: Vicky C H
authors.initials: VC
authors.lastname: Lai
authors.forename: Brett J
authors.initials: BJ
authors.lastname: Prigaro
authors.forename: Yili
authors.initials: Y
authors.lastname: Ding
authors.forename: Esmir
authors.initials: E
authors.lastname: Gunic
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Girardet
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhong
authors.forename: Zhi
authors.initials: Z
authors.lastname: Hong
authors.forename: Stanley
authors.initials: S
authors.lastname: Lang
authors.forename: Haoyun
authors.initials: H
authors.lastname: An
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D012263:Ribonucleosides; C023764:triciribine