Selective lesioning of the cholinergic septo-hippocampal pathway does not disrupt spatial short-term memory: a comparison with the effects of fimbria-fornix lesions.
Rats receiving intrahippocampal injections of 192 IgG-saporin (SAP-HPC), fimbria-fornix lesions (FF), or sham control surgeries were tested in a series of delayed matching (DMTP)- and nonmatching (DNMTP)-to-position tasks. The FF group was significantly impaired on a pretrained DNMTP task relative to the control and SAP-HPC groups, which did not differ. All groups then acquired a matching-to- position rule at the same rate, and only the FF group showed a delay-dependent deficit when longer retention intervals were introduced for DMTP testing. Results demonstrate the importance of the fimbria-fornix fiber system in spatial short-term memory but suggest that the cholinergic septohippocampal component of this pathway is not required for successful delayed matching (or nonmatching)-to-position performance.
Winters
Boyer D
BD
Medical Research Council Cambridge Centre for Brain Repair, and Departmernt of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom. bdw23@cam.ac.uk
Dunnett
Stephen B
SB
D000109:Acetylcholine / Q000378:metabolism; D000110:Acetylcholinesterase / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000911:Antibodies, Monoclonal / Q000633:toxicity; D001522:Behavior, Animal; D002452:Cell Count / Q000379:methods; D018678:Cholinergic Agents / Q000633:toxicity; D020712:Fornix, Brain / Q000293:injuries / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007150:Immunohistochemistry / Q000379:methods; D000922:Immunotoxins / Q000633:toxicity; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D009699:N-Glycosyl Hydrolases; D009434:Neural Pathways / Q000502:physiology; D010320:Parvalbumins / Q000378:metabolism; D051381:Rats; D054789:Ribosome Inactivating Proteins, Type 1; D000076985:Saporins; D012688:Septum Pellucidum / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*
C085696:192 IgG-saporin; D000911:Antibodies, Monoclonal; D018678:Cholinergic Agents; D000922:Immunotoxins; D010320:Parvalbumins; D054789:Ribosome Inactivating Proteins, Type 1; D000110:Acetylcholinesterase; D009699:N-Glycosyl Hydrolases; D000076985:Saporins; D000109:Acetylcholine