A novel asymmetric route to succinimides and derived compounds: synthesis of the lignan lactone (+)-hinokinin.
A novel approach to chiral succinimides and derived compounds has been developed that involves chiral lithium amide desymmetrisation of an N-ortho-tert-butylphenyl succinimide to generate a putative atropisomeric intermediate enolate, alkylation of which enables access to the lignan lactone (+)-hinokinin.
Bennett
D Jonathan
DJ
School of Chemistry, The University of Nottingham, University Park, Nottingham, UKNG7 2RD.
Pickering
Paula L
PL
Simpkins
Nigel S
NS