[Immunomodulating effect of the novel water-soluble gossypol derivative Mebavin in adjuvant arthritis].
Investigation of the effect of mebavin on the model of adjuvant arthritis showed that this drug administered in a dose of 100 mg/kg exhibits immunomodulant and anti-inflammatory activity without negative influence on the nonspecific response of the organism. Combined administration of mebavin with prednisolone provides for a more effective and nontoxic treatment of adjuvant arthritis.
Sabirova
F M
FM
Department of Experimental Medicine and Pathologic Anatomy, State Center of Emergency Medicine, ul. Farhod 2, Tashkent, 700107 Uzbekistan.
Urazmetova
M D
MD
Madaminov
A A
AA
D000276:Adjuvants, Immunologic / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000276:immunology; D001562:Benzimidazoles / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D006072:Gossypol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014867:Water
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D001562:Benzimidazoles; C488150:almide; D014867:Water; D011239:Prednisolone; D006072:Gossypol