Thyroid hormone receptor subtypes and their interaction with steroid receptor coactivators.
Thyroid hormone (TH) is required for normal growth, development, and metabolism in metazoans. To influence this broad range of physiologic actions, TH is necessarily involved in the regulation of a multitude of genes in virtually every tissue. The diversity of gene expression regulation in response to TH is mediated through specific intranuclear TH receptors (TRs) and other nuclear coregulators. This chapter reviews TRs and nuclear coregulators, specifically coactivators, based on in vivo data from knockout (KO) mouse models.
Weiss
Roy E
RE
University of Chicago, Thyroid Study Unit, Chicago, Illinois 60637, USA.
Ramos
Helton E
HE
D000123:Acetyltransferases; D000818:Animals; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D020868:Gene Silencing / Q000502:physiology; D051548:Histone Acetyltransferases; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3; D015513:Oncogene Proteins; D020033:Protein Isoforms / Q000235:genetics; D011988:Receptors, Thyroid Hormone / Q000378:metabolism / Q000502:physiology*; D013961:Thyroid Gland / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D015513:Oncogene Proteins; D020033:Protein Isoforms; D011988:Receptors, Thyroid Hormone; D013963:Thyroid Hormones; D015534:Trans-Activators; D014157:Transcription Factors; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C538859:NCOA1 protein, human; C538866:NCOA3 protein, human; C538861:Ncoa1 protein, mouse; C538867:Ncoa3 protein, mouse; D056920:Nuclear Receptor Coactivator 1; D056921:Nuclear Receptor Coactivator 3