Virological and immunological impact of non-nucleoside reverse transcriptase inhibitor withdrawal in HIV-infected patients with multiple treatment failures.
No significant changes in viral load and CD4 cell count were observed 2-4 weeks after the withdrawal of non-nucleoside reverse transcriptase inhibitors (NNRTI) from the current therapy of patients exhibiting resistance mutations to this class of drugs. The data suggest that in the presence of specific resistance mutations NNRTIexert no residual antiretroviral activity and could be withdrawn without viral rebound.
Piketty
Christophe
C
Gérard
Laurence
L
Chazallon
Corine
C
Calvez
Vincent
V
Clavel
François
F
Taburet
Anne-Marie
AM
Girard
Pierre-Marie
PM
Aboulker
Jean-Pierre
JP
D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D009154:Mutation / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D017211:Treatment Failure; D019562:Viral Load
D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors