title: Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine.
abstract: OBJECTIVE
  To investigate the effect of mycophenolate mofetil on Walker's carcinosarcoma, without versus with the growth and regression of cyclosporine.
  
  
  RESULTS
  Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 +/- 2.8 cm(3)) than control rats (14.9 +/- 4.2 cm(3), P <.05), and similar to that in CsA-N (13.9 +/- 3.0 cm(3)). However, tumor weight (TW) was significantly lower in MMF (5.2 +/- 2.0 g) than CsA-N (8.8 +/- 2.1g) or control hosts (7.3 +/- 2.0 g, P < or =.01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls.
  
  
  CONCLUSIONS
  MMF produces an anti-tumoral effect against Walker's carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor.
authors.affiliation: Renal Transplant Unit, Medical School, Ceará Federal University, Fortaleza-Ceará, Brazil. sonials@baydenet.com.br
authors.forename: S L
authors.initials: SL
authors.lastname: Silva
authors.forename: S F R
authors.initials: SF
authors.lastname: Silva
authors.forename: R O
authors.initials: RO
authors.lastname: Cavalcante
authors.forename: R S
authors.initials: RS
authors.lastname: Mota
authors.forename: R A
authors.initials: RA
authors.lastname: Carvalho
authors.forename: M O
authors.initials: MO
authors.lastname: Moraes
authors.forename: H H
authors.initials: HH
authors.lastname: Campos
authors.forename: M E A
authors.initials: ME
authors.lastname: Moraes
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D016572:Cyclosporine / Q000627:therapeutic use; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid