title: Reduction of pleural effusion by OK-432 in a fetus complicated with congenital hydrothorax.
abstract: A 29-year-old, primiparous woman was referred to our hospital at 21 weeks of gestation because of right pleural effusion in the fetus shown by routine ultrasonographic examination. Cytology revealed abundant lymphocytes, suggesting chylothorax. We removed the pleural effusion and injected OK-432 into the chest cavity at 24 and 25 weeks of gestation. Pleural effusion declined and an adhesion between the lung surface and the pleural membrane seemed to form. At 33 weeks of gestation, a female infant was born by cesarean section (1,090 g and Apgar score 6/8). Although she demonstrated slight retraction and tachypnea, management could be achieved by administration of oxygen alone without mechanical ventilation. Later, the baby was diagnosed as suffering from the Cornelia de Lange syndrome with characteristic features. OK-432 injections could thus prevent complications of chylothorax and hypoplastic lungs, without injury to either the baby or the mother.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan. og.yo@med.nagoya-cu.ac.jp
authors.forename: Ayumi
authors.initials: A
authors.lastname: Tsukihara
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Tanemura
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.forename: Taihei
authors.initials: T
authors.lastname: Tanaka
authors.forename: Kaoru
authors.initials: K
authors.lastname: Suzumori
mesh_terms: D000328:Adult; D005260:Female; D046128:Fetal Therapies / Q000379:methods*; D006801:Humans; D006876:Hydrothorax / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010844:Picibanil / Q000008:administration & dosage*; D010996:Pleural Effusion / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011247:Pregnancy; D014463:Ultrasonography
chemical_list: D010844:Picibanil