title: Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers.
abstract: Recent studies have indicated that the most important role of beta-amyloid peptide (Abeta) in the etiology of Alzheimer's disease may not be in plaque formation but in the formation of soluble, metastable Abeta(1-42) neurotoxic intermediates (called ADDLs). In the present work we describe the preparation of per-6-amino-6-deoxy-beta-cyclodextrins, which inhibit ADDLs formation in vitro.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Chang
authors.forename: William L
authors.initials: WL
authors.lastname: Klein
authors.forename: Gregory R J
authors.initials: GR
authors.lastname: Thatcher
authors.forename: Duane L
authors.initials: DL
authors.lastname: Venton
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D016229:Amyloid beta-Peptides; D003505:Cyclodextrins; D009842:Oligopeptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)