Protein tyrosine phosphatases in the human genome.
Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.
Alonso
Andres
A
Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Sasin
Joanna
J
Bottini
Nunzio
N
Friedberg
Ilan
I
Friedberg
Iddo
I
Osterman
Andrei
A
Godzik
Adam
A
Hunter
Tony
T
Dixon
Jack
J
Mustelin
Tomas
T
D000595:Amino Acid Sequence / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D010766:Phosphorylation; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D014443:Tyrosine / Q000378:metabolism*
D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases