Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer.
Tamoxifen (TAM) is commonly used as an adjuvant treatment for breast cancer. Although patients taking TAM are often taking medications for comorbidities, data regarding the interaction of TAM with other medications are limited. Thus, this study was carried out to determine whether medications co-prescribed with TAM significantly influence the plasma concentrations of TAM and its metabolites (N-desmethyltamoxifen; N-DMT and 4-hydroxytamoxifen; 4-OHT) in 98 women diagnosed with breast cancer. Participants taking diuretics had significantly higher plasma concentrations of TAM and N-DMT than participants not taking a diuretic. Arthritis/pain medication intake was negatively associated with plasma TAM concentrations. Chemotherapeutic agents, allergy drugs, anti-depressants, and diabetes medications did not significantly alter plasma TAM or metabolite concentrations. This suggests that diuretic or an arthritis/pain medication may affect TAM metabolism.
Gallicchio
Lisa
L
Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, 660 W. Redwood Street, Baltimore, MD 21201, USA.
Tkaczuk
Katherine
K
Lord
Gwyn
G
Danton
Malcolm
M
Lewis
Lynn M
LM
Lim
Chang K
CK
Flaws
Jodi A
JA
D018926:Anti-Allergic Agents / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000378:metabolism / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D017024:Chemotherapy, Adjuvant; D004965:Estrogen Antagonists / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008875:Middle Aged; D050607:Organogold Compounds; D013629:Tamoxifen / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use
D018926:Anti-Allergic Agents; D000924:Anticholesteremic Agents; D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D018931:Antineoplastic Agents, Hormonal; D018501:Antirheumatic Agents; D004965:Estrogen Antagonists; D007004:Hypoglycemic Agents; D050607:Organogold Compounds; D013629:Tamoxifen