Alveolar adenoma of the lung: a clinicopathologic, immunohistochemical, and molecular study of an unusual case.
We describe an alveolar adenoma of the lung with 3 previously unreported findings, which expand both the clinical and the morphologic spectrum of this rare tumor: presentation as a cystic nodule, foci of mature adipocytes, and S-100 positivity of the mesenchymal cells. Furthermore, using a laser capture microdissection technique under microscope visualization, we analyzed multiple chromosomal loci in both the epithelial and mesenchymal components of the lesion, showing microsatellite alterations and loss of heterozygosity in the former but not in the latter.
Cavazza
Alberto
A
Department of Pathology, S. Maria Nuova Hospital, Reggio Emilia, Italy.
Paci
Massimiliano
M
De Marco
Loredana
L
Leporati
Guido
G
Sartori
Giuliana
G
Bigiani
Nazzarena
N
Rossi
Giulio
G
D000236:Adenoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007834:Lasers; D019656:Loss of Heterozygosity / Q000235:genetics; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D042282:Microdissection / Q000295:instrumentation; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D004273:DNA, Neoplasm; D009418:S100 Proteins