[Lipid spectrum of lymphocyte plasma membranes in abstinent syndrome in patients with opioid dependence].
The lipid composition of the lymphocyte plasmatic membranes was studied in the withdrawal syndrome as observed in patients with opioid addiction. The method of thin-layer chromatography was used to identify the lipid fractions. Higher cholesterol content, a bigger trans-membrane asymmetry index and a higher ratio between cholesterol and total phospholipids were detected. The contents of the lysophospholipid fraction and of the total fraction of phosphatidylcholine and serine were increasing. The contents of cholesterol ethers as well as of the fractions of sphingomyelin and phosphatidyl ethanolamine were found to be lower.
Serebrov
V Iu
VIu
Balashov
P P
PP
Sharypova
N G
NG
D000293:Adolescent; D000328:Adult; D002462:Cell Membrane / Q000737:chemistry; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry*; D008563:Membrane Lipids / Q000097:blood*; D009293:Opioid-Related Disorders / Q000097:blood*; D013375:Substance Withdrawal Syndrome / Q000097:blood*
D008563:Membrane Lipids