Inorganic delivery vector for intravenous injection.
Uniform, small-sized (100-200 nm), layered double hydroxides (LDH) were prepared by a conventional, wet chemistry method using different aging times of 1 and 3 days as an inorganic drug or gene delivery carrier. The samples prepared had a hexagonal thin, plate-like shape and TEM/SAD electron microscopy of LDH particles indicated that they were single crystals. In vivo testing of empty LDH administered to adult male Sprague Dawley rats was done to evaluate the possibility of using LDH as an injectable drug delivery vehicle.
Kwak
Seo-Young
SY
Materials Science and Engineering, University of Illinois at Urbana-Champaign, 1304 W Green St, 61801, USA.
Kriven
Waltraud M
WM
Wallig
Matthew A
MA
Choy
Jin-Ho
JH
D000818:Animals; D006878:Hydroxides / Q000008:administration & dosage*; D007275:Injections, Intravenous; D007287:Inorganic Chemicals; D008297:Male; D046529:Microscopy, Electron, Transmission; D051381:Rats; D017207:Rats, Sprague-Dawley; D014961:X-Ray Diffraction
D006878:Hydroxides; D007287:Inorganic Chemicals