title: From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits.
abstract: In the adult mammalian central nervous system (CNS), growth of neuronal fibers is actively inhibited by myelin. The proteins myelin-associated glycoprotein (MAG), oligodendrocyte myelin glycoprotein (OMgP), and Nogo-66 have been identified as inhibitory components present in CNS myelin. All three proteins exert their inhibitory activity by binding to a neuronal receptor complex containing the Nogo-66 receptor (NgR) and the neurotrophin (NT) receptor p75NTR. In their recent publication, Mi et al. identify the novel protein Lingo-1 as an interactor of p75NTR and NgR. The Lingo-1-NgR-p75NTR complex is shown to confer the inhibitory effects on nerve cell regeneration of Nogo-66, OMgP, and MAG by activating the small guanosine triphosphatase (GTPase) RhoA. Together with the recent finding that p75NTR interacts with the transmembrane protein sortilin to form a different receptor complex with cell death-promoting activity, the results of Mi et al. indicate that p75NTR exerts its diverse cellular functions by associating with function-specific co-receptors.
authors.affiliation: Institute for Medical Chemistry and Biochemistry, Division of Neurobiochemistry, Innsbruck Medical University, 6020 Innsbruck, Austria.
authors.forename: Christine
authors.initials: C
authors.lastname: Bandtlow
authors.forename: Georg
authors.initials: G
authors.lastname: Dechant
mesh_terms: D016923:Cell Death / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D021122:Protein Subunits / Q000502:physiology*; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D021122:Protein Subunits; D020800:Receptor, Nerve Growth Factor; D017475:Receptors, Nerve Growth Factor