Vascular disease and inflammation.
The past decade has witnessed a dramatic shift in the understanding of the causes of atherosclerotic vascular disease. What was once considered to be a process of abnormal lipid deposition in the vascular wall is now understood to be a dynamic inflammatory process from inception through plaque growth, rupture and ultimately thrombosis. This article reviews the basic science research that supports this growing body of epidemiologic data and discusses the inflammatory markers that predict future clinical events,as well as the pharmacologic success in therapies that specifically target inflammation.
Giacobbe
Dean T
DT
Department of Anesthesiology, University of Pennsylvania, Philadelphia, PA, USA.
Murray
Michael J
MJ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D012307:Risk Factors; D014652:Vascular Diseases / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology
D000893:Anti-Inflammatory Agents