title: Purpura fulminans due to Streptococcus pneumoniae sepsis following gastric bypass.
abstract: An older female underwent bariatric surgery which was followed by a significant weight loss and diarrhea, from which C. difficile was isolated just before her hospitalization. Less than 48 hours after admission, she became febrile, developed deep venous thrombosis of the leg and a pulmonary embolus. Blood cultures grew out Streptococcus pneumoniae and the patient developed purpura fulminans. There was convincing laboratory evidence for disseminated intravascular coagulation and a marked depletion of proteins C and S as well as antithrombin. Treatment with ceftriaxone and drotrecogin alfa together with parenteral nutrition led to disappearance of the pathogen and ultimate normalization of the anticoagulant factors. We believe that malabsorption of vitamin K dependent proteins C, S and antithrombin due to bariatric surgery predisposed the patient to purpura fulminans and disseminated intravascular coagulation.
authors.affiliation: Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA 92270, USA. laconemedico@aol.com
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Cone
authors.forename: Robert
authors.initials: R
authors.lastname: B Waterbor
authors.forename: Mark V
authors.initials: MV
authors.lastname: Sofonio
mesh_terms: D000991:Antithrombins / Q000032:analysis; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology; D005260:Female; D015390:Gastric Bypass / Q000009:adverse effects*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000382:microbiology*; D008286:Malabsorption Syndromes / Q000097:blood / Q000150:complications* / Q000209:etiology; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000097:blood / Q000150:complications*; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D018805:Sepsis / Q000150:complications / Q000382:microbiology*; D014657:Vasculitis / Q000473:pathology
chemical_list: D000991:Antithrombins; D011486:Protein C; D017293:Protein S