title: [Hepatosplenic candidiasis in acute myeloid leukemia].
abstract: Chronic diseminated candidiasis--mainly its hepatosplenic form- is one of the most characteristic invasive infection due to Candida in haematological patients. A case is presented of a 31 year old man admitted to the Clinical Department with acute mieloid leukosis M2, showing febrile neutropenia after induction and consolidation chemotherapy. Hepatoesplenic candidiasis was diagnosed and confirmed by computered axial tomography (CAT) and hepatic biopsy; amphotericin B followed by liposome encapsuled amphotericin B up to complete a total dose of 4 g was used for treatment. The patient was discharged waiting for bone marrow transplantation. Early suspicion of hepatosplenic candidiasis helps to select a rapid diagnosis method and an effective treatment.
authors.affiliation: Hospital Municipal de Agudos Dr Leónidas Lucero, Servicios de Hematología, Hemoterapia, Clínica Medica y Laboratorio Central, Estomba 968, 8000 Bahía Blanca, Argentina. gdomi@ciudad.com.ar
authors.forename: A
authors.initials: A
authors.lastname: Larregina
authors.forename: B
authors.initials: B
authors.lastname: Bartoletti
authors.forename: H
authors.initials: H
authors.lastname: Romano
authors.forename: L
authors.initials: L
authors.lastname: Paniccia
authors.forename: N N
authors.initials: NN
authors.lastname: Polini
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology*; D003840:Deoxycholic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D042241:Early Diagnosis; D005334:Fever / Q000209:etiology; D006529:Hepatomegaly / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications; D013163:Splenomegaly / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D008081:Liposomes; D003840:Deoxycholic Acid; D000666:Amphotericin B; C059765:amphotericin B, deoxycholate drug combination