Asymmetric hydrogenation of o-alkoxy-substituted arylenamides.
A series of (2-alkoxyaryl)glycinols have been prepared in up to 97.8% ee by asymmetric hydrogenation with cationic rhodium Me-BPE or Me-DuPhos complexes. Others have shown that the presence of ortho substituents on related alpha-arylenamides causes a decrease in enantioselectivity. However, in this study it was found that o-alkoxy alpha-arylenamides were reduced with high enantioselectivity irrespective of substituent size.
Cong-Dung Le
Julie
J
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Pagenkopf
Brian L
BL