Reversibility of thyrotroph hyperplasia after L-thyroxine replacement therapy in patients with juvenile primary hypothyroidism.
Thyrotroph cell hyperplasia in primary hypothyroidism though well described is often not discussed as it remains clinically silent. This hyperplasia in long standing juvenile primary hypothyroidism presenting as 'pituitary tumor' is very uncommon. We report four patients with juvenile primary hypothyroidism, who were detected to have sellar/suprasellar masses on imaging performed for unrelated symptoms, and complete resolution in three of them after L-thyroxine replacement therapy.
Bhansali
A
A
Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. anilbhansali_endocrine@rediffmail.com
Sreenivasulu
P
P
Khandelwal
N
N
Masoodi
S R
SR
D000293:Adolescent; D000328:Adult; D001491:Basophils / Q000187:drug effects / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D006965:Hyperplasia; D007037:Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000473:pathology*; D013974:Thyroxine / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D013974:Thyroxine