Synergistic inhibition of lipid peroxidation by vitamin E and a dopamine agonist, cabergoline.
We examined antioxidant activity of cabergoline, a dopamine agonist, during the aerobic oxidation of phosphatidylcholine liposomes at 37 degrees C. Cabergoline retarded the oxidation initiated with a lipid-soluble initiator significantly better than that with a water-soluble initiator, suggesting that cabergoline locates in the lipid layer of liposomal membranes. Cabergoline inhibited the oxidation of liposomal membranes synergistically with endogenous antioxidants such as ascorbic acid, ubiquinol-10 and vitamin E, and vitamin E was the most efficient synergist. These results suggest that cabergoline may have a neuroprotective effect on the substantia nigra of Parkinsonian patients because of its synergistic antioxidant activity with vitamin E as well as its action on dopamine receptor.
Sohmiya
Makoto
M
Department of Neurology, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. sohmiyam@med.gunma-u.ac.jp
Tanaka
Makoto
M
Okamoto
Koichi
K
Fujisawa
Akio
A
Yamamoto
Yorihiro
Y
D000975:Antioxidants / Q000494:pharmacology*; D000077465:Cabergoline; D018491:Dopamine Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004873:Ergolines / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D018491:Dopamine Agonists; D004873:Ergolines; D008081:Liposomes; D014810:Vitamin E; D000077465:Cabergoline