Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP.
Calcium and guanosine-3',5'-cyclic monophosphate (cGMP) are second messenger molecules that regulate opposing physiological functions, reflected in the reciprocal regulation of their intracellular concentrations, in many systems. Indeed, cGMP and Ca2+ constitute discrete points of integration between multiple cell signaling cascades in both convergent and parallel pathways. This chapter describes the molecular mechanisms regulating intracellular Ca2+ and cGMP, and their integration in specific cellular responses.
Tiyyagura
Satish R
SR
Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Kazerounian
Shiva
S
Schulz
Stephanie
S
Waldman
Scott A
SA
Pitari
Giovanni M
GM
D000818:Animals; D002118:Calcium / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D006801:Humans
D006152:Cyclic GMP; D002118:Calcium