title: Spontaneous regression of a primary cerebral tumor following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm--case report.
abstract: A 40-year-old man demonstrated spontaneous regression of a malignant glioma following vasospasm caused by subarachnoid hemorrhage due to rupture of an intracranial aneurysm. The patient had been treated under a diagnosis of malignant glioma for 5 years. He presented with a ruptured aneurysm manifesting as subarachnoid hemorrhage. Single photon emission computed tomography with N-isopropyl-p-123I-iodoamphetamine and diffusion-weighted magnetic resonance (MR) imaging revealed severe flow reduction due to vasospasm in the bilateral temporoparietal cortical regions, including the tumor. MR imaging performed 5 months later showed marked tumor regression. The present case suggests that treatment targeting angiogenesis of malignant gliomas may be effective as a part of multimodality treatment.
authors.affiliation: Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
authors.forename: Yoji
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kumabe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimizu
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ezura
authors.forename: Teiji
authors.initials: T
authors.lastname: Tominaga
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000150:complications*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D002533:Cerebral Angiography; D005910:Glioma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D012075:Remission, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D020301:Vasospasm, Intracranial / Q000150:complications*