Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats.
The alcoholic extract of Hydrocotyle asiatica Linn. (Hydrocotyle asiatica L.) whole plant was evaluated for cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats. Cardioprotective activity was studied by measuring infarct size and estimating lipid peroxide levels in serum and heart tissue. A lead II electrocardiogram was monitored at various intervals throughout the experiment. A dose (100-1000 mg kg(-1)) dependent reduction in percent left ventricle necrosis (PLVN) as well as in lipid peroxide levels was observed in rats treated with alcoholic extract of Hydrocotyle asiatica L. orally for 7 days compared to control animals. The study strongly suggests the cardioprotective activity of Hydrocotyle asiatica L. in limiting ischemia-reperfusion induced myocardial injury.
Pragada
R R
RR
Pharmacology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, Andhra Pradesh, India. rajeswararaopragada@rediffmail.com
Veeravalli
K K
KK
Chowdary
K P R
KP
Routhu
K V
KV
D000818:Animals; D002316:Cardiotonic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D028041:Centella; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D002316:Cardiotonic Agents; D010936:Plant Extracts