Familial monozygotic twinning: report of an extended multi-generation family.
Thirteen sets of monozygotic (MZ) twins from an extended multi-generation family are reported. Zygosity was determined by interviewing families for overall physical similarity and by assessment of facial photographs. A hypothetical gene was traced back five generations to a common grandfather. Familial monozygotic twinning in this pedigree is compatible with autosomal dominant inheritance with reduced penetrance. Other plausible mechanisms of inheritance are discussed.
Hamamy
Hanan A
HA
National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan.
Ajlouni
Heitham K
HK
Ajlouni
Kamel M
KM
D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D011795:Surveys and Questionnaires; D014430:Twins, Monozygotic / Q000235:genetics