title: Heteronuclear selective refocusing 2D NMR experiments for the spectral analysis of enantiomers in chiral oriented solvents.
abstract: We report the use of carbon-proton heteronuclear selective refocusing 2D NMR experiments dedicated to the spectral analysis of enantiomers dissolved in weakly ordering chiral liquid crystalline solvents. The method permits the extraction of carbon-proton residual dipolar couplings for each enantiomer from a complex or unresolved proton-coupled 13C spectral patterns. Illustrative examples are analysed and discussed. It is shown that an accurate determination of enantiomeric excess is possible.
authors.affiliation: Laboratoire de Chimie Structurale Organique, UMR CNRS 8074, Université Paris-Sud, ICMMO, Bât. 410, 91405 Orsay Cedex, France.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Farjon
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Baltaze
authors.forename: Philippe
authors.initials: P
authors.lastname: Lesot
authors.forename: Denis
authors.initials: D
authors.lastname: Merlet
authors.forename: Jacques
authors.initials: J
authors.lastname: Courtieu
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D007536:Isomerism; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011407:Propane / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry*; D012996:Solutions; D012997:Solvents / Q000032:analysis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D012996:Solutions; D012997:Solvents; C010440:dibromopropane; D011407:Propane