title: Drosophila development: RNA interference ab ovo.
abstract: A novel protein required for RNA interference in Drosophila, Armitage, was identified in a screen for genes involved in embryonic axis formation. In armitage mutants, oocyte polarity and the regulation of oskar mRNA translation are impaired, suggesting that RNA silencing regulates the first steps of Drosophila development.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. chekulae@emble.de
authors.forename: Marina
authors.initials: M
authors.lastname: Chekulaeva
authors.forename: Anne
authors.initials: A
authors.lastname: Ephrussi
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D016764:Cell Polarity; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D009865:Oocytes / Q000166:cytology; D009866:Oogenesis / Q000502:physiology; D020365:RNA Helicases / Q000235:genetics*; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex; C091675:osk protein, Drosophila; C484034:armi protein, Drosophila; D020365:RNA Helicases