Capillary electrophoresis and mass spectrometry for screening of metabolic disorders in newborns.
Clinical analyses always represent a challenge for the sensitivity and selectivity of the analytical techniques. Of the most critical are the techniques required for the quick determination of the disease state and application of the proper treatment in newborns. This short critical review overviews the present state of the art of the use of mass spectrometry and capillary electrophoresis for screening of metabolic disorders in newborns.
Senk
Petr
P
Institute of Analytical Chemistry, University Hospital Brno, Veverí 97, CZ-61142 Brno, Czech Republic.
Kozák
Libor
L
Foret
Frantisek
F
D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D013058:Mass Spectrometry / Q000379:methods*; D008659:Metabolic Diseases