title: Protein interaction networks from yeast to human.
abstract: Protein interaction networks summarize large amounts of protein-protein interaction data, both from individual, small-scale experiments and from automated high-throughput screens. The past year has seen a flood of new experimental data, especially on metazoans, as well as an increasing number of analyses designed to reveal aspects of network topology, modularity and evolution. As only minimal progress has been made in mapping the human proteome using high-throughput screens, the transfer of interaction information within and across species has become increasingly important. With more and more heterogeneous raw data becoming available, proper data integration and quality control have become essential for reliable protein network reconstruction, and will be especially important for reconstructing the human protein interaction network.
authors.affiliation: European Molecular Biology Laboratory, Structural and Computational Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany. bork@embl-heidelberg.de
authors.forename: Peer
authors.initials: P
authors.lastname: Bork
authors.forename: Lars J
authors.initials: LJ
authors.lastname: Jensen
authors.forename: Christian
authors.initials: C
authors.lastname: von Mering
authors.forename: Arun K
authors.initials: AK
authors.lastname: Ramani
authors.forename: Insuk
authors.initials: I
authors.lastname: Lee
authors.forename: Edward M
authors.initials: EM
authors.lastname: Marcotte
mesh_terms: D000818:Animals; D005544:Forecasting; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D025941:Protein Interaction Mapping; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D011786:Quality Control
chemical_list: D005656:Fungal Proteins; D011506:Proteins