[Effect of lysozyme on the functional and metabolic activity of polymorphonuclear leukocytes in the acute blood loss].
Acute hemorrhage leads to a decrease in the phagocyte number and index, the NBT test parameters, and the NADPH oxidase activity and to an increase in the Ca2+ ATPase activity in polymorphonuclear leukocytes on the peripheral blood. Lysozyme produces effective correction of the above parameters of the functional-metabolic activity of these cells. The drug effect is mediated by cytokines of splenocytes sticking to the glass.
Rybnikov
V N
VN
Department of Obstetrics and Gynecology, Kursk State Medical University, ul. K. Marksa 3, Kursk, 305033 Russia.
Brovkina
I L
IL
Uteshev
B S
BS
D000208:Acute Disease; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000097:blood; D016207:Cytokines / Q000378:metabolism; D006470:Hemorrhage / Q000097:blood / Q000517:prevention & control*; D009113:Muramidase / Q000097:blood / Q000494:pharmacology*; D019255:NADPH Oxidases / Q000097:blood; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism / Q000473:pathology
D016207:Cytokines; D019255:NADPH Oxidases; D009113:Muramidase; D000252:Calcium-Transporting ATPases