Vitamin D status and bone turnover in women with acute hip fracture.
Hypovitaminosis D is common in elderly women. Few data are available on vitamin D status and bone turnover in women with acute hip fracture. The aims of this study were to determine whether elderly Italian women with an acute hip fracture also had low vitamin D levels and an increase of bone turnover compared with elderly women with osteoporosis but without fractures. Seventy-four women with acute osteoporotic hip fracture and 73 women with postmenopausal osteoporosis were studied. All women were self-sufficient and had adequate sunlight exposure. To exclude the effect of trauma on serum 25-hydroxycolecalciferol levels and bone markers (bone alkaline phosphatase and C-terminal telopeptides of Type I collagen as indices of bone formation and bone resorption), blood samples were drawn within 24 hours of the fracture. Current data indicated that in our patients the prevalence of hypovitaminosis D is common although to a lesser extent than in women who are housebound. Women with acute hip fractures had a higher prevalence of vitamin deficiency defined as serum 25-hydroxycolecalciferol lower than 12 ng/mL, compared with women with osteoporosis. Moreover, the presence of fracture did not influence the rate of bone formation, whereas the increase in bone resorption could be attributed to an older age of women with acute hip fracture because of similar values of parathyroid hormone levels in the two groups.
Nuti
Ranuccio
R
Metabolic Disease Unit, University of Siena, Siena, Italy. nutir@unisi.it
Martini
Giuseppe
G
Valenti
Roberto
R
Gambera
Dario
D
Gennari
Luigi
L
Salvadori
Stefania
S
Avanzati
Annalisa
A
D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D001862:Bone Resorption / Q000503:physiopathology*; D016022:Case-Control Studies; D015331:Cohort Studies; D003720:Densitometry; D005260:Female; D005500:Follow-Up Studies; D006620:Hip Fractures / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D015994:Incidence; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D014807:Vitamin D / Q000032:analysis / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000175:diagnosis* / Q000453:epidemiology
D015415:Biomarkers; D014807:Vitamin D