title: Giant intracranial Rosai-Dorfman disease.
abstract: Rosai-Dorfman disease is a rare, non-neoplastic disease characterized by an unusual proliferation of histiocytic cells. It rarely manifests intracranially, and only 50 cases of intracranial lesions have been reported. We describe an unusual case of a huge, solid mass in the paranasal sinuses, orbits, cavernous sinuses, and suprasellar cisterns. A 29-year-old patient was admitted to our hospital with nasal obstruction and proptosis and visual loss in the right eye. A biopsy was done at another institution and the diagnosis was "pseudotumor of orbit". A right-sided cranio-orbitozygomatic craniotomy combined with a right-sided lateral rhinotomy was used to excise the tumor with right orbital exenteration. The histopathological diagnosis was consistent with Rosai-Dorfman disease. The patient underwent postoperative chemotherapy. Involvement of the central nervous system in Rosai-Dorfman disease is rare, but the disease's ability to mimic other pathologies underlines its importance.
authors.affiliation: Department of Neurosurgery, Marmara University School of Medicine, Istanbul, Turkey. ugurture@tnn.net
authors.forename: Uğur
authors.initials: U
authors.lastname: Türe
authors.forename: Aşkin
authors.initials: A
authors.lastname: Seker
authors.forename: Süheyla Uyar
authors.initials: SU
authors.lastname: Bozkurt
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Uneri
authors.forename: Aydin
authors.initials: A
authors.lastname: Sav
authors.forename: M Necmettin
authors.initials: MN
authors.lastname: Pamir
mesh_terms: D000328:Adult; D003399:Craniotomy / Q000379:methods; D015618:Histiocytosis, Sinus / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010256:Paranasal Sinuses / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods