title: Histologic reactions to particulate wear debris in different mesenchymal tissues: studies on the nonreplaced compartment from revised uni-knees.
abstract: The interface between bone and artificial-joint implants consists of soft tissue. This tissue varies from fibrocartilage to loose fibrous tissue. Tissues that resemble those can be found in normal joints. Sixteen knees with unicompartmental knee prostheses, revised because of excessive wear of the tibial insert, were studied. Synovium, synovial fluid, cartilage, and bone from the nonreplaced compartment were studied with light microscopy. We found wear particles and reactions to those in all tissues except cartilage. In the subchondral bone, we found osteolytic-like processes undermining the cartilage peripherally. Our conclusion from these findings is that the histologic composition of the bone-implant interface might be an important factor regarding the reaction of the tissue to wear particles and, thus, component fixation.
authors.affiliation: Department of Orthopaedics, Lund University Hospital, University of Lund, Sweden.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Hansson
authors.forename: Gordon
authors.initials: G
authors.lastname: Blunn
authors.forename: Leif
authors.initials: L
authors.lastname: Ryd
mesh_terms: D000368:Aged; D002358:Cartilage, Articular / Q000473:pathology; D005260:Female; D005549:Foreign-Body Reaction / Q000175:diagnosis*; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000601:surgery; D010014:Osteolysis / Q000175:diagnosis*; D011475:Prosthesis Failure; D012086:Reoperation; D013582:Synovial Fluid