Translesion DNA synthesis: little fingers teach tolerance.
DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.
Fleck
Oliver
O
Institute of Molecular Cancer Research, University of Zürich, August-Forel Strasse 7, CH-8008 Zürich, Switzerland.
Schär
Primo
P
D001483:Base Sequence / Q000235:genetics; D004249:DNA Damage; D004261:DNA Replication / Q000235:genetics / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D009154:Mutation / Q000235:genetics; D011487:Protein Conformation
D004259:DNA-Directed DNA Polymerase