Antifungal cobalt(II), copper(II), nickel(II) and zinc(II) complexes of furanyl-,thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins.
Some novel cephalexin-derived furanyl, thiophenyl, pyrrolyl, salicylyl and pyridyl Schiff's bases and their cobalt (II), copper (II), nickel (II) and zinc (II) complexes have been synthesized and studied for their antifungal properties against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glaberata. The presence of metal ions in the investigated Schiff's base complexes reported here lead to significant antifungal activity, whereas the parent ligands were generally less active.
Chohan
Zahid H
ZH
Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
Pervez
Humayun
H
Khan
Khalid M
KM
Rauf
A
A
Maharvi
Ghulam M
GM
Supuran
Claudiu T
CT
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D041221:Candida glabrata / Q000187:drug effects; D002506:Cephalexin / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D005670:Fusarium / Q000187:drug effects; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008864:Microsporum / Q000187:drug effects; D009532:Nickel / Q000737:chemistry; D010621:Phenazopyridine / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D014249:Trichophyton / Q000187:drug effects; D015032:Zinc / Q000737:chemistry
D000935:Antifungal Agents; D005663:Furans; D008670:Metals; D011758:Pyrroles; D012459:Salicylates; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc; D010621:Phenazopyridine; D002506:Cephalexin; C039281:furan