p53-mediated transcriptional activation: from test tube to cell.
Posttranslational modifications of histones have been strongly correlated with transcriptional regulation. In this issue of Cell, comprehensively examined the nature of arginine methyltransferases and histone modifications in p53-mediated transcription.
Fingerman
Ian M
IM
Department of Biochemistry, Purdue University, 175 South University Street, West Lafayette, IN 47907, USA.
Briggs
Scott D
SD
D000818:Animals; D005809:Genes, Regulator / Q000235:genetics*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation / Q000235:genetics / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
D006657:Histones; D016159:Tumor Suppressor Protein p53; D011484:Protein-Arginine N-Methyltransferases; C119966:coactivator-associated arginine methyltransferase 1