GPI-anchor synthesis: Ras takes charge.
A new study shows that Ras2 regulates GPI-anchor synthesis in the ER. Reciprocally, the targeted enzyme GPI-GlcNAc transferase regulates Ras2 signal output. This novel intersection of Ras2 signaling and an ER-localized protein complex has interesting implications for Ras function.
Hancock
John F
JF
Institute for Molecular Bioscience, University of Queensland Brisbane 4072, Australia.
D002462:Cell Membrane / Q000201:enzymology / Q000235:genetics; D004721:Endoplasmic Reticulum / Q000201:enzymology* / Q000235:genetics; D005656:Fungal Proteins; D017261:Glycosylphosphatidylinositols / Q000096:biosynthesis* / Q000235:genetics; D046911:Macromolecular Substances; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
D005656:Fungal Proteins; D017261:Glycosylphosphatidylinositols; D046911:Macromolecular Substances; D017351:N-Acetylglucosaminyltransferases; C063057:UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase; D018631:ras Proteins