title: Genetics of ribosome-inactivating proteins.
abstract: Ribosome-inactivating proteins (RIPs) are a heterogeneous group of enzymes found mainly in plants and a few bacteria that possess N-glycosidase activity on ribosomes and a related polynucleotide adenosine glycosidase activity on naked nucleic acids. They encompass single enzymatic chains, heterodimeric toxic lectins and related agglutinins. Plants commonly produce several RIP isoforms encoded by multi-gene families. The toxic lectins possess adaptations related to their cytotoxic role.
authors.affiliation: Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK. MHartley@bio.warwick.ac.uk
authors.forename: Martin R
authors.initials: MR
authors.lastname: Hartley
authors.forename: J Michael
authors.initials: JM
authors.lastname: Lord
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D011506:Proteins / Q000145:classification / Q000235:genetics* / Q000494:pharmacology; D012270:Ribosomes / Q000187:drug effects*
chemical_list: D011506:Proteins