[P-selectin as endothelial reactivity marker in patients with pre-eclampsia].
BACKGROUND
Pre-eclampsia affects 5% of all pregnancies. The physiopathologic hallmark is altered endothelium function and platelet activation. Selectins are molecules involved with the regulation between these systems, P-selectin is a molecule expressed in platelet membrane. Our objective was to describe the role of P-selectin on endothelial reactivity in patients with pre-eclampsia compared with normal pregnancies.


METHODS
Blood samples from 30 patients with severe pre-eclampsia (cases) were compared with patients with 30 normal pregnancies during labor (controls). Samples from both groups were analyzed using ELISA (Bender Med kit, Vienna, Austria) for determination of P-selectin.


RESULTS
We compared main clinical, biochemical, and hematologic variables in both groups, identifying an outstanding difference in expression of P-selectin between them.


CONCLUSIONS
P-selectin is a marker of endothelium activation in patients with severe pre-eclampsia.
Salazar-Exaire
José Daniel
JD
Unidad de Investigación Hospital de Especialidades, México.
Reyes-Martínez
Ruth Iliana
RI
González-Alvarez
Raúl
R
Briones-Garduño
Jesús Carlos
JC
D015415:Biomarkers; D002634:Chemotaxis, Leukocyte / Q000502:physiology; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation; D009504:Neutrophils; D019007:P-Selectin / Q000097:blood* / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D011897:Random Allocation
D015415:Biomarkers; D019007:P-Selectin