title: [Association of malignant tumors of the conjunctiva and HIV infection in Kinshasa (D. R. Congo). First results].
abstract: BACKGROUND
  Conjunctival carcinomas are tumors especially of the 6th/7th decades. They occur in Germany with a frequency of 1/20,000. For years it has been well known that in Africa the number of malignant tumors of the conjunctiva has been increasing. The reasons for that are not well known. HIV is a possible pathogenetic cofactor.
  
  
  METHODS
  A histological examination of 34 specimens was performed in Rostock on conjunctival tumors removed at the Ophthalmologic Department of the University of Kinshasa in 2001. The study included 23 female and 11 male patients aged 20-75 years (mean 42). All patients underwent serological investigation for HIV infection.
  
  
  RESULTS
  Of 34 patients 18 were HIV positive. Of the HIV-positive patients, six had a squamous cell carcinoma, seven a CIN (conjunctival intraepithelial neoplasia) I-III, and five a pinguecula. Of the HIV-negative patients, five showed a squamous cell carcinoma, eight a CIN I-III, one a pinguecula, one a sebaceous gland carcinoma, and one a papilloma. The average age of the HIV-positive patients with a squamous cell carcinoma was 41 years compared to the HIV-negative patients with 58 years.
  
  
  CONCLUSIONS
  There was no difference in frequency of conjunctival intraepithelial neoplasia between HIV-positive or HIV-negative patients. HIV-positive patients with a squamous cell carcinoma were on average 17 years younger. UV radiation is the main risk factor and HIV infection is a possible carcinogenic cofactor. Investigations on additional viral infections as possible pathogenetic factors and on changed tumor suppressor genes are needed.
authors.affiliation: Augenklinik, Universität, Rostock, Deutschland. angela.timm@med.uni-rostock.de
authors.forename: A
authors.initials: A
authors.lastname: Timm
authors.forename: G
authors.initials: G
authors.lastname: Stropahl
authors.forename: M
authors.initials: M
authors.lastname: Schittkowski
authors.forename: C
authors.initials: C
authors.lastname: Sinzidi
authors.forename: D
authors.initials: D
authors.lastname: Kayembe
authors.forename: R
authors.initials: R
authors.lastname: Guthoff
mesh_terms: D015492:AIDS Serodiagnosis; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000453:epidemiology* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D015897:Comorbidity; D003228:Conjunctiva / Q000473:pathology / Q000601:surgery; D003230:Conjunctival Neoplasms / Q000453:epidemiology* / Q000473:pathology; D015023:Democratic Republic of the Congo; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000473:pathology; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology