Post-transplant lymphoproliferative disorders presenting as gingival overgrowth in patients immunosuppressed with ciclosporin. A report of two cases.
BACKGROUND
Post-transplant lymphoproliferative disorder (PTLD) can occur in patients maintained on immunosuppressive therapy following transplantation. This paper describes two cases of PTLD occurring in gingival tissues, in patients receiving ciclosporin following cardiac transplantation.


METHODS
The lesions were localised to gingival tissues, mimicking ciclosporin-induced gingival overgrowth. They were removed surgically and the ciclosporin dose reduced to help prevent recurrence.


CONCLUSIONS
The importance of histopathological examination of all tissue removed during routine gingivectomy procedures for ciclosporin-induced gingival overgrowth is highlighted.
Rolland
S L
SL
School of Dental Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK. s.l.rolland@ncl.ac.uk
Seymour
R A
RA
Wilkins
B S
BS
Parry
G
G
Thomason
J M
JM
D016572:Cyclosporine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005887:Gingival Neoplasms / Q000175:diagnosis*; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000175:diagnosis; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged
D007166:Immunosuppressive Agents; D016572:Cyclosporine