title: Fractional scan algorithms for low-dose perfusion CT.
abstract: One of the key considerations in CT perfusion is the X-ray dose received by the patient, since cine acquisition mode is typically used in which repeated x-ray exposure occurs at the same anatomical location. In this technical note, we propose a new approach for dose reduction in which the X-ray tube current is maintained and the number of projection views is reduced per gantry rotation. A projection interpolation algorithm and an image prediction algorithm are developed to address the incompleteness of such projection data. Both algorithms utilize a priori knowledge that the contrast-uptake in perfusion images is gradual and predictable. As a result, excellent perfusion images can be reconstructed at a fraction of the nominal radiation dose.
authors.affiliation: GE Medical Systems, Milwaukee, Wisconsin 53201, USA. jiang.hsieh@med.ge.com
authors.forename: Jiang
authors.initials: J
authors.lastname: Hsieh
authors.forename: Yuchuan
authors.initials: Y
authors.lastname: Wei
authors.forename: Ge
authors.initials: G
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging; D003287:Contrast Media; D006801:Humans; D011832:Radiation Injuries / Q000517:prevention & control*; D011835:Radiation Protection / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000009:adverse effects* / Q000379:methods*
chemical_list: D003287:Contrast Media