title: Results of ajmaline testing in patients with arrhythmogenic right ventricular dysplasia-cardiomyopathy.
abstract: An association between arrhythmogenic right ventricular dysplasia-cardiomyopathy (ARVD/C) and Brugada syndrome can be supposed according to several case reports. In order to examine a possible link between ARVD/C and Brugada syndrome, systematic ajmaline testing with 1 mg/kg body weight intravenously, was done in 55 patients (32 males, mean age 46.7+/-12.3 years) with ISFC/ESC criteria of ARVD/C. In nine patients ajmaline testing could demonstrate coved ST segment elevation of at least 2 mm in at least two right precordial leads. Three of these patients had recurrent syncopes. Electrophysiological study revealed non-sustained ventricular tachycardia with left bundle branch block configuration and inferior axis in only one case. Systematic ajmaline testing could demonstrate a definite link between ARVD/C and Brugada syndrome.
authors.affiliation: Klinikum Dorothea Christiane Erxleben gGmbH Quedlinburg, Department of Cardiology, Academic Teaching Hospital of the University Hospital Magdeburg, Ditfurter Weg 24, 06484 Quedlinburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Peters
authors.forename: Martina
authors.initials: M
authors.lastname: Trümmel
authors.forename: Stefan
authors.initials: S
authors.lastname: Denecke
authors.forename: Brigitte
authors.initials: B
authors.lastname: Koehler
mesh_terms: D000328:Adult; D000368:Aged; D000404:Ajmaline; D000889:Anti-Arrhythmia Agents; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D002037:Bundle-Branch Block / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013575:Syncope / Q000503:physiopathology; D013577:Syndrome; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents; D000404:Ajmaline