Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.
A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM.
Bloom
Jonathan D
JD
Chemical and Screening Sciences and Infectious Disease Research, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. bloomj@wyeth.com
Dushin
Russell G
RG
Curran
Kevin J
KJ
Donahue
Fran
F
Norton
Emily B
EB
Terefenko
Eugene
E
Jones
Thomas R
TR
Ross
Adma A
AA
Feld
Boris
B
Lang
Stanley A
SA
DiGrandi
Martin J
MJ
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000998:Antiviral Agents; D013890:Thiourea