title: Breakpoint identification and smoothing of array comparative genomic hybridization data.
abstract: CONCLUSIONS
  We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data.
  
  
  BACKGROUND
  aCGH-Smooth is free for researchers at academic and non-profit institutions at http://www.few.vu.nl/~vumarray/.
authors.affiliation: Faculty of Sciences, Vrije Universiteit, De Boelelaan 1117, Amsterdam 1081HV, The Netherlands. cjong@few.vu.nl <cjong@few.vu.nl>
authors.forename: Kees
authors.initials: K
authors.lastname: Jong
authors.forename: Elena
authors.initials: E
authors.lastname: Marchiori
authors.forename: Gerrit
authors.initials: G
authors.lastname: Meijer
authors.forename: A V D
authors.initials: AV
authors.lastname: Vaart
authors.forename: Bauke
authors.initials: B
authors.lastname: Ylstra
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D004252:DNA Mutational Analysis / Q000379:methods*; D018628:Gene Dosage; D020869:Gene Expression Profiling / Q000379:methods; D017403:In Situ Hybridization / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012984:Software