Progress on new vaccine strategies for the immunotherapy and prevention of cancer.
In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal tissues. This review examines the fundamental immunologic advances and the novel vaccine strategies arising from these advances, as well as the early clinical trials studying new approaches to treat or prevent cancer.
Berzofsky
Jay A
JA
Molecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. berzofsk@helix.nih.gov
Terabe
Masaki
M
Oh
SangKon
S
Belyakov
Igor M
IM
Ahlers
Jeffrey D
JD
Janik
John E
JE
Morris
John C
JC
D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology / Q000494:pharmacology*; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*; D019444:Vaccines, DNA / Q000276:immunology / Q000494:pharmacology; D022223:Vaccines, Subunit / Q000276:immunology; D014780:Viruses
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D019444:Vaccines, DNA; D022223:Vaccines, Subunit