Long-lived Drosophila with overexpressed dFOXO in adult fat body.
Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated the timing of the effect of reduced IIS on life-span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a downstream effector of IIS, in the adult Drosophila fat body, which increased life-span and reduced fecundity of females but had no effect on male life-span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity.
Giannakou
Maria E
ME
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.
Goss
Martin
M
Jünger
Martin A
MA
Hafen
Ernst
E
Leevers
Sally J
SJ
Partridge
Linda
L
D000818:Animals; D030801:Animals, Genetically Modified; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005216:Fat Body / Q000378:metabolism*; D005260:Female; D005298:Fertility; D051858:Forkhead Transcription Factors; D015870:Gene Expression; D008136:Longevity; D008297:Male; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D029721:Drosophila Proteins; C477334:FOXO protein, Drosophila; D051858:Forkhead Transcription Factors; D014157:Transcription Factors