[Intraocular pressure in rabbits after administration of 10% L-arginine HCl in 2% Trusopt].
In this contribution publish the observation that addition of 10% L-arginin.HCl to the 2% Trusopt eye drops intensifies activity of antiglaucomatics with an important reduction of the normal intraocular pressure (IOP) in rabbits New Zealand white namely from 15 up to 240 minutes, compared with application of both substance alone. Size of the pupil was not affected. Based on our experimental results we assume that this increasing activity of Trusopt mixture with amino acid L-arginin.HCl created a new metabolite. According to our observations this metabolite caused reduction of the humor aqueous production and together with the increased of the uveo-scleral outflow leads to the striking reduction of the IOP.
Veselovský
J
J
Katedra zivocísnej fyziológie a etológie Prif UK, Bratislava.
Oláh
Z
Z
Veselá
A
A
Gressnerová
S
S
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001120:Arginine / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D005901:Glaucoma / Q000188:drug therapy; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D011817:Rabbits; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013876:Thiophenes / Q000008:administration & dosage / Q000494:pharmacology*
D000959:Antihypertensive Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013876:Thiophenes; D001120:Arginine; C062765:dorzolamide