title: [Hairy cell leukemia, Japanese variant, successfully treated with cladribine].
abstract: A 67-year-old male was admitted because of lymphocytosis and huge splenomegaly. Abnormal lymphocytes had cytoplasmic hairy projections and were negative for tartrate-resistant acid phosphatase staining. The bone marrow aspirate contained many lymphocytes with the same morphology. Flow cytometric analysis revealed an increase in IgM and kappa positive B cells. They were positive for CD11c, CD19, CD20 and FMC7, and negative for CD5, CD10 and CD25. The patient was diagnosed as having hairy cell leukemia, Japanese variant. Initially interferon-alpha was administered for a month, decreasing the numbers of leukemic cells but with little effect on splenomegaly. Subsequent administration of cladribine (0.09 mg/kg, 7 days) showed a remarkable effect, and the patient has been in complete remission for 8 months.
authors.affiliation: Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital.
authors.forename: Mutsuko
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Taguchi
authors.forename: Shizu
authors.initials: S
authors.lastname: Sakuragi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Mitani
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Matsuda
authors.forename: Kenji
authors.initials: K
authors.lastname: Shinohara
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017338:Cladribine / Q000627:therapeutic use*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy*; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine