title: Cyclosporine increases endothelin-1 plasma levels in renal transplant recipients.
abstract: Endothelin-1 (ET-1) has been associated with the development of hypertension in cyclosporine-treated renal transplant recipients. To clarify this association, this observational study compared ET-1 levels in 33 patients taking cyclosporine therapy versus 10 controls. Three hours after cyclosporine administration, ET-1 levels were higher than in the controls, namely 1.81 + 0.99 versus 1.17 + 0.46 pg/mL (P <.04). These results suggest a role of ET-1 in the pathogenesis of post-renal transplantation hypertension in cyclosporine-treated recipients.
authors.affiliation: Renal Division, Hospital de Clínicas de Porto Alegre and Post-Graduation in Medical Sciences, Nephrology Program, Rio Grande do Sul Federal University, Porto Alegre, RS, Brazil.
authors.forename: R L
authors.initials: RL
authors.lastname: Cauduro
authors.forename: C
authors.initials: C
authors.lastname: Costa
authors.forename: F
authors.initials: F
authors.lastname: Lhulier
authors.forename: R G
authors.initials: RG
authors.lastname: Garcia
authors.forename: R D
authors.initials: RD
authors.lastname: Cabral
authors.forename: L E
authors.initials: LE
authors.lastname: Gonçalves
authors.forename: R C
authors.initials: RC
authors.lastname: Manfro
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology; D016030:Kidney Transplantation / Q000276:immunology*; D007700:Kinetics; D008297:Male; D013997:Time Factors
chemical_list: D019332:Endothelin-1; D016572:Cyclosporine; D001379:Azathioprine