title: Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative.
abstract: The aggregation and DNA binding behavior of a new G-quadruplex selective ligand, 6a,12a-diazadibenzo-[a,g]fluorenylium derivative, was studied by UV-vis absorption and fluorescence spectroscopy. The formation of ligand aggregates with different spectral characteristics was observed at low and high concentration of NaCl, respectively. The ligand binds to G-quadruplex with much higher affinity than to single- and double-stranded DNA.
authors.affiliation: Faculty of Chemistry, A. Mickiewicz University, 60-780 Poznan, Poland. juskowia@amu.edu.pl
authors.forename: Bernard
authors.initials: B
authors.lastname: Juskowiak
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Galezowska
authors.forename: Natalia
authors.initials: N
authors.lastname: Koczorowska
authors.forename: Tadeusz W
authors.initials: TW
authors.lastname: Hermann
mesh_terms: D001372:Aza Compounds / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D004277:DNA, Single-Stranded / Q000378:metabolism; D005449:Fluorenes / Q000737:chemistry / Q000378:metabolism*; D005456:Fluorescent Dyes; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry*; D008024:Ligands; D009690:Nucleic Acid Conformation; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001372:Aza Compounds; D004277:DNA, Single-Stranded; D005449:Fluorenes; D005456:Fluorescent Dyes; D008024:Ligands; D006147:Guanine; D004247:DNA