title: A case of hypertrophic osteoarthropathy associated with epithelioid hemangioendothelioma.
abstract: Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome characterized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jin Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Eun Bong
authors.initials: EB
authors.lastname: Lee
authors.forename: Sunyoung
authors.initials: S
authors.lastname: Kim
authors.forename: Hyoun Woo
authors.initials: HW
authors.lastname: Kang
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Suh
authors.forename: Won Jae
authors.initials: WJ
authors.lastname: Yoon
authors.forename: Su Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Kang
authors.forename: Churl Hyun
authors.initials: CH
authors.lastname: Im
authors.forename: Yeong Wook
authors.initials: YW
authors.lastname: Song
authors.forename: Hyo-Suk
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000328:Adult; D001706:Biopsy; D001792:Blood Platelets / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism; D005269:Femur / Q000000981:diagnostic imaging; D018323:Hemangioendothelioma, Epithelioid / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000150:complications* / Q000473:pathology*; D011859:Radiography; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D042461:Vascular Endothelial Growth Factor A