title: Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP.
abstract: Calcium and guanosine-3',5'-cyclic monophosphate (cGMP) are second messenger molecules that regulate opposing physiological functions, reflected in the reciprocal regulation of their intracellular concentrations, in many systems. Indeed, cGMP and Ca2+ constitute discrete points of integration between multiple cell signaling cascades in both convergent and parallel pathways. This chapter describes the molecular mechanisms regulating intracellular Ca2+ and cGMP, and their integration in specific cellular responses.
authors.affiliation: Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
authors.forename: Satish R
authors.initials: SR
authors.lastname: Tiyyagura
authors.forename: Shiva
authors.initials: S
authors.lastname: Kazerounian
authors.forename: Stephanie
authors.initials: S
authors.lastname: Schulz
authors.forename: Scott A
authors.initials: SA
authors.lastname: Waldman
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Pitari
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D020013:Calcium Signaling / Q000502:physiology*; D006152:Cyclic GMP / Q000502:physiology*; D006801:Humans
chemical_list: D006152:Cyclic GMP; D002118:Calcium