Health-related quality of life in juvenile-onset systemic lupus erythematosus and its relationship to disease activity and damage.
OBJECTIVE
To assess the health-related quality of life (HRQL) of patients with juvenile-onset systemic lupus erythematosus (JSLE) and its relationship with disease activity and accumulated damage.


METHODS
In this cross-sectional study, HRQL was assessed using the Child Health Questionnaire (CHQ), disease activity using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and accumulated damage using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI).


RESULTS
A total of 297 patients were included. The mean +/- SD physical and psychosocial summary scores of the CHQ were 40.2 +/- 15.0 and 44.8 +/- 10.7, respectively. The most impaired CHQ subscales were global health, general health perceptions, and parent impact-emotional. The SLEDAI score was significantly correlated with both the physical summary score (r = -0.29, P < 0.0001) and psychosocial summary score (r = -0.25, P < 0.0001), whereas the SDI score was significantly correlated only with the physical summary score (r = -0.23, P = 0.0001).


CONCLUSIONS
We found that patients with JSLE have significant impairment of their HRQL, particularly in the physical domain. HRQL may be affected by both disease activity and accumulated damage, particularly in the renal, central nervous, and musculoskeletal systems.
Ruperto
Nicolino
N
Università di Genova, Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genoa, Italy.
Buratti
Silvia
S
Duarte-Salazar
Carolina
C
Pistorio
Angela
A
Reiff
Andreas
A
Bernstein
Bram
B
Maldonado-Velázquez
Maria Rocío
MR
Beristain-Manterola
Rosalía
R
Maeno
Nobuaki
N
Takei
Syuji
S
Falcini
Fernanda
F
Lepore
Loredana
L
Spencer
Charles H
CH
Pratsidou-Gertsi
Polixeni
P
Martini
Alberto
A
Ravelli
Angelo
A
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001171:Arthritis, Juvenile / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D016022:Case-Control Studies; D002493:Central Nervous System Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D009140:Musculoskeletal Diseases / Q000209:etiology; D011584:Psychology; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires