Endobronchial clear cell adenocarcinoma occurring in a patient 15 years after treatment for DES-associated vaginal clear cell adenocarcinoma.
BACKGROUND
Clear cell adenocarcinoma (CCA) of the vagina and cervix in young women is associated with prenatal exposure to diethylstilbestrol (DES). Parenchymal pulmonary metastases are known to occur following treatment of the primary tumor. Most recurrences present within 2 to 3 years of the initial diagnosis.


METHODS
This is a case report of a solitary endobronchial clear cell adenocarcinoma occurring 15.3 years after the initial diagnosis of DES-induced CCA.


CONCLUSIONS
This case suggests that management of clear cell cancer survivors should involve long-term follow-up because of the potential for the appearance of a new focus of clear cell adenocarcinoma.
Hall
William B
WB
Medical School, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-9535, USA.
Detterbeck
Frank C
FC
Livasy
Chad A
CA
Fowler
Wesley C
WC
D018262:Adenocarcinoma, Clear Cell / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D001984:Bronchial Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000473:pathology
D004968:Estrogens, Non-Steroidal; D004054:Diethylstilbestrol