title: Bilateral cleft lip and palate, hypertelorism and hypoplastic toes.
abstract: We report on a 23-month-old boy with bilateral cleft lip and palate, marked hypertelorism, frontal bossing and severe bilateral, asymmetric hypoplasia of toes. The mother used bisoprolol, naproxen and sumatriptan for migraine until the fifth postmenstrual week of pregnancy. We suggest that this patient's features represent a previously undescribed entity of as yet unknown aetiology.
authors.affiliation: Clinical Genetics Unit, Helsinki University Central Hospital, Helsinki, Finland Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland The Family Federation of Finland, Helsinki, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Kajantie
authors.forename: Mirja
authors.initials: M
authors.lastname: Somer
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D017298:Bisoprolol / Q000009:adverse effects; D002971:Cleft Lip / Q000150:complications / Q000175:diagnosis*; D002972:Cleft Palate / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005532:Foot Deformities, Congenital / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006972:Hypertelorism / Q000150:complications / Q000175:diagnosis*; D007223:Infant; D008297:Male; D018811:Maternal Exposure; D009288:Naproxen / Q000009:adverse effects; D011247:Pregnancy; D018170:Sumatriptan / Q000009:adverse effects; D014662:Vasoconstrictor Agents / Q000009:adverse effects
chemical_list: D000319:Adrenergic beta-Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014662:Vasoconstrictor Agents; D009288:Naproxen; D018170:Sumatriptan; D017298:Bisoprolol