A randomised trial of single-dose radiotherapy to prevent procedure tract metastasis by malignant mesothelioma.
A single 9-MeV electron treatment, following invasive thoracic procedures in patients with malignant pleural mesothelioma, was examined. In all, 58 sites were randomised to prophylactic radiotherapy or not. There was no statistically significant difference in tract metastasis. A single 10-Gy treatment with 9-MeV electrons appears ineffective.
Bydder
S
S
Department of Radiation Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Perth, Nedlands, WA 6009, Australia. sean.bydder@health.wa.gov.au
Phillips
M
M
Joseph
D J
DJ
Cameron
F
F
Spry
N A
NA
DeMelker
Y
Y
Musk
A W
AW
D000368:Aged; D000369:Aged, 80 and over; D004583:Electrons / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000532:radiotherapy* / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009360:Neoplastic Cells, Circulating; D010997:Pleural Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D016896:Treatment Outcome