The role of claustrum in Pavlovian heart rate conditioning in the rabbit (Oryctolagus cuniculus): anatomical, electrophysiological, and lesion studies.
The role of the claustrum in Pavlovian heart rate (HR) conditioning was studied in the rabbit (Oryctolagus cuniculus) by (a) mapping claustral projections to the prefrontal cortex (PFC), (b) recording claustral single-unit discharge to sensory stimulation and conditioning stimuli during HR conditioning, and (c) assessing the effects of claustral damage on HR conditioning. Contralateral and ipsilateral claustral projections to the PFC were found. Claustral cells responded to nonsignal stimulation with increased discharge and also showed conditioned stimulus-evoked increases in discharge during Pavlovian HR conditioning. Moreover, claustral lesions diminished the magnitude of the HR-conditioned response without affecting the cardiac-orienting response to the conditioned stimulus or the cardiac-unconditioning response to the unconditioned stimulus, suggesting a role for the claustrum in associative learning.
Chachich
Mark E
ME
Shirley L. Buchanan Neuroscience Laboratory, William Jennings Bryan Dorn Veterans Affairs Medical Center, 6439 Garners Ferry Road, Columbia, SC 29209-1639, USA.
Powell
D A
DA
D000200:Action Potentials / Q000502:physiology / Q000528:radiation effects; D000704:Analysis of Variance; D000818:Animals; D001479:Basal Ganglia / Q000166:cytology / Q000293:injuries / Q000502:physiology*; D001522:Behavior, Animal; D002452:Cell Count; D003214:Conditioning, Classical / Q000502:physiology*; D004307:Dose-Response Relationship, Radiation; D004572:Electrolysis / Q000009:adverse effects; D004576:Electromyography; D004594:Electrophysiology; D004597:Electroshock / Q000379:methods; D005260:Female; D005456:Fluorescent Dyes / Q000378:metabolism; D006339:Heart Rate / Q000502:physiology*; D008297:Male; D009434:Neural Pathways; D009445:Neuroanatomy; D009474:Neurons / Q000145:classification / Q000502:physiology; D010812:Physical Stimulation / Q000379:methods; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology; D011817:Rabbits; D012018:Reflex / Q000502:physiology / Q000528:radiation effects; D013266:Stilbamidines / Q000378:metabolism
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines