Effect of (3,5,6-trimethylpyrazin-2-yl)methyl 2-[4-(2-methylpropyl)phenyl]propanoate (ITE), a newly developed anti-inflammatory drug, on type II collagen-induced arthritis in mice.
The effect of (3,5,6-trimethylpyrazin-2-yl)methyl 2-[4-(2-methylpropyl)phenyl]propanoate (ITE) on type II collagen (CII)-induced arthritis in mice was studied. Mice were immunized twice with CII, ITE being given orally once a day for 40 d after the 1st immunization. Clinical assessment showed that ITE had no effect on the day of onset of arthritis but did lowered the incidence rate of arthritis and the arthritis score. And ITE had a marked suppressive effect on the mouse hind paw edema induced by CII. ITE suppressed the delayed-type mouse ear skin reaction to CII but had no effect on the level of serum anti-CII antibodies. These results suggest that ITE inhibits the development of CII-induced arthritis in mice by suppressing delayed-type hypersensitivity to CII.
Ma
Tao
T
Department of Pharmacology, Shenyang Pharmaceutical University, China. Wangmatao@sina.com
Cao
Ying-Lin
YL
Xu
Bei-Bei
BB
Zhou
Xiao-Mian
XM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D024043:Collagen Type II / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D011422:Propionates / Q000737:chemistry* / Q000627:therapeutic use*; D011719:Pyrazines / Q000737:chemistry* / Q000627:therapeutic use*
C495410:(3,5,6-trimethylpyrazin-2-yl)methyl 2-(4-(2-methylpropyl)phenyl)propanoate; D000894:Anti-Inflammatory Agents, Non-Steroidal; D024043:Collagen Type II; D011422:Propionates; D011719:Pyrazines