title: New insights into imiquimod's mechanisms of action.
abstract: Imiquimod, an immune response modifier with potent antiviral and antitumor properties, has been reported to be effective in the treatment of various cutaneous neoplasms. Besides stimulating the production of pro-inflammatory cytokines through Toll-like receptors on the surface of dendritic cells of monocyte-macrophage lineage, novel antiapoptotic mechanisms have been identified.
authors.affiliation: Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. martinmubarak@aol.com
authors.forename: Rafael F
authors.initials: RF
authors.lastname: Martín-García
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000279:Administration, Cutaneous; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D000077271:Imiquimod; D008562:Membrane Glycoproteins / Q000819:agonists / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000819:agonists / Q000378:metabolism; D012878:Skin Neoplasms / Q000188:drug therapy; D051193:Toll-Like Receptors
chemical_list: D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D000077271:Imiquimod