title: A structural perspective on protein-protein interactions.
abstract: Structures of macromolecular complexes are necessary for a mechanistic description of biochemical and cellular processes. They can be solved by experimental methods, such as X-ray crystallography, NMR spectroscopy and electron microscopy, as well as by computational protein structure prediction, docking and bioinformatics. Recent advances and applications of these methods emphasize the need for hybrid approaches that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness.
authors.affiliation: EMBL, Heidelberg, Germany.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Russell
authors.forename: Frank
authors.initials: F
authors.lastname: Alber
authors.forename: Patrick
authors.initials: P
authors.lastname: Aloy
authors.forename: Fred P
authors.initials: FP
authors.lastname: Davis
authors.forename: Dmitry
authors.initials: D
authors.lastname: Korkin
authors.forename: Matthieu
authors.initials: M
authors.lastname: Pichaud
authors.forename: Maya
authors.initials: M
authors.lastname: Topf
authors.forename: Andrej
authors.initials: A
authors.lastname: Sali
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray / Q000379:methods; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008854:Microscopy, Electron / Q000379:methods; D008958:Models, Molecular; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D040681:Structural Homology, Protein; D014054:Tomography / Q000379:methods
chemical_list: D011506:Proteins