title: Therapeutic time window for musicokinetic therapy in a persistent vegetative state after severe brain damage.
abstract: OBJECTIVE
  To determine the therapeutic time window in which musicokinetic therapy (MKT) could be of potential benefit for a persistent vegetative state (PVS), this study analysed the relationship between the timing of MKT and changes in PVS score following MKT.
  
  
  METHODS
  Twenty-six patients who fulfilled the definition of PVS were treated consecutively by MKT employing a trampoline with live music performance for 3 months. The PVS score ranges from 0-30 and the condition which meets the definition of PVS is never scored greater than 20.
  
  
  RESULTS
  As compared to patients with brain damage caused by trauma (n=12) or subarachnoid haemorrhage (SAH; n=9), those caused by other cerebrovascular accidents (n=3) or anoxic encephalopathy (n=2) appeared to demonstrate a much smaller improvement in their PVS score. When the patients caused by trauma or SAH were analysed in isolation, the effects of MKT were clearly better in those patients in whom the MKT was initiated within 6 months after brain damage. Among nine patients caused by trauma or SAH who had been in a PVS for more than 12 months, however, six (66.7%) demonstrated improvement of their PVS score by 5 or more and four (33.3%) reached a post-MKT score of greater than 20.
  
  
  CONCLUSIONS
  These findings suggest that, contrary to the commonly held belief, the therapeutic time window for MKT is far greater than 6 months, insofar as patients with brain damage caused by trauma or SAH are concerned. Although the benefits of MKT were not proven directly, this inference is consistent with the hypothesis that MKT can induce an improvement in the clinical condition of PVS patients.
authors.affiliation: Arts Planning Department, Osaka University of Arts, Osaka, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Noda
authors.forename: Yukio
authors.initials: Y
authors.lastname: Maeda
authors.forename: Atsuo
authors.initials: A
authors.lastname: Yoshino
mesh_terms: D000059:Accidents; D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement; D009147:Music Therapy / Q000379:methods*; D018458:Persistent Vegetative State / Q000209:etiology / Q000534:rehabilitation*; D010775:Photic Stimulation; D018709:Statistics, Nonparametric; D020521:Stroke / Q000150:complications; D013345:Subarachnoid Hemorrhage / Q000150:complications; D013997:Time Factors; D016896:Treatment Outcome