title: Mu-heavy chain disease associated with systemic amyloidosis.
abstract: mu-heavy chain disease (HCD) is very rare, with only 30 cases reported in the literature. We report a patient with mu-HCD associated with systemic amyloidosis. The diagnosis of mu-HCD was based on findings of mu-heavy chain fragments in the serum, Bence Jones proteinuria and vacuolated plasma cells in the bone marrow. To our knowledge, this is the third case in which systemic amyloidosis led to the patient's death.
authors.affiliation: Department of Hematology, Nephrology and Rheumatology, Kinki Univeristy School of Medicine, Osaka-Sayama, Osaka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Yamagata
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nozaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sugiyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Ikoma
authors.forename: Masanori
authors.initials: M
authors.lastname: Funauchi
authors.forename: Akihisa
authors.initials: A
authors.lastname: Kanamaru
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000150:complications*; D001536:Bence Jones Protein / Q000652:urine; D001853:Bone Marrow / Q000473:pathology; D006362:Heavy Chain Disease / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000097:blood; D007148:Immunoglobulin mu-Chains / Q000097:blood; D008297:Male
chemical_list: D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D001536:Bence Jones Protein