title: Health-related quality of life in juvenile-onset systemic lupus erythematosus and its relationship to disease activity and damage.
abstract: OBJECTIVE
  To assess the health-related quality of life (HRQL) of patients with juvenile-onset systemic lupus erythematosus (JSLE) and its relationship with disease activity and accumulated damage.
  
  
  METHODS
  In this cross-sectional study, HRQL was assessed using the Child Health Questionnaire (CHQ), disease activity using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and accumulated damage using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI).
  
  
  RESULTS
  A total of 297 patients were included. The mean +/- SD physical and psychosocial summary scores of the CHQ were 40.2 +/- 15.0 and 44.8 +/- 10.7, respectively. The most impaired CHQ subscales were global health, general health perceptions, and parent impact-emotional. The SLEDAI score was significantly correlated with both the physical summary score (r = -0.29, P < 0.0001) and psychosocial summary score (r = -0.25, P < 0.0001), whereas the SDI score was significantly correlated only with the physical summary score (r = -0.23, P = 0.0001).
  
  
  CONCLUSIONS
  We found that patients with JSLE have significant impairment of their HRQL, particularly in the physical domain. HRQL may be affected by both disease activity and accumulated damage, particularly in the renal, central nervous, and musculoskeletal systems.
authors.affiliation: Università di Genova, Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genoa, Italy.
authors.forename: Nicolino
authors.initials: N
authors.lastname: Ruperto
authors.forename: Silvia
authors.initials: S
authors.lastname: Buratti
authors.forename: Carolina
authors.initials: C
authors.lastname: Duarte-Salazar
authors.forename: Angela
authors.initials: A
authors.lastname: Pistorio
authors.forename: Andreas
authors.initials: A
authors.lastname: Reiff
authors.forename: Bram
authors.initials: B
authors.lastname: Bernstein
authors.forename: Maria Rocío
authors.initials: MR
authors.lastname: Maldonado-Velázquez
authors.forename: Rosalía
authors.initials: R
authors.lastname: Beristain-Manterola
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Maeno
authors.forename: Syuji
authors.initials: S
authors.lastname: Takei
authors.forename: Fernanda
authors.initials: F
authors.lastname: Falcini
authors.forename: Loredana
authors.initials: L
authors.lastname: Lepore
authors.forename: Charles H
authors.initials: CH
authors.lastname: Spencer
authors.forename: Polixeni
authors.initials: P
authors.lastname: Pratsidou-Gertsi
authors.forename: Alberto
authors.initials: A
authors.lastname: Martini
authors.forename: Angelo
authors.initials: A
authors.lastname: Ravelli
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001171:Arthritis, Juvenile / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D016022:Case-Control Studies; D002493:Central Nervous System Diseases / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006304:Health Status; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology* / Q000523:psychology*; D008297:Male; D009140:Musculoskeletal Diseases / Q000209:etiology; D011584:Psychology; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires