Microarray analysis and functional characterization of the nitrosative stress response in nonmucoid and mucoid Pseudomonas aeruginosa.
The type strain of Pseudomonas aeruginosa, PAO1, showed great upregulation of many nitrosative defense genes upon treatment with S-nitrosoglutathione, while the mucoid strain PAO578II showed no further upregulation above its constitutive upregulation of nor and fhp. NO* consumption however, showed that both strains mount functional, protein synthesis-dependent NO*-consumptive responses.
Firoved
Aaron M
AM
College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Wood
Simon R
SR
Ornatowski
Wojciech
W
Deretic
Vojo
V
Timmins
Graham S
GS
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D018869:Heat-Shock Response; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000254:growth & development* / Q000502:physiology*; D026422:S-Nitrosoglutathione / Q000494:pharmacology*; D015854:Up-Regulation
D001426:Bacterial Proteins; D009569:Nitric Oxide; D026422:S-Nitrosoglutathione