Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection.
BACKGROUND
Although extracellular heat-shock protein 70 (Hsp70) potentially mediates an inflammatory response, the association of circulating Hsp70 with complications after surgery is poorly understood.


METHODS
Perioperative plasma concentrations of Hsp70 and interleukin-6 were measured by immunoassays in 64 consecutive patients undergoing liver resection.


RESULTS
Plasma concentrations of Hsp70 and interleukin-6 showed a striking increase immediately after surgery, and on postoperative day 1. The Hsp70 levels correlated significantly with operation time, hepatic ischemia time, postoperative alanine aminotransferase levels, and maximum interleukin-6 levels (P <0.01). The Hsp70 and interleukin-6 concentrations were associated significantly with postoperative infection (P <0.05); Hsp70 concentrations and blood loss but not interleukin-6 were associated significantly with postoperative organ dysfunction (P <0.05) in multivariate analyses.


CONCLUSIONS
These results suggest that circulating Hsp70 and IL-6 potentially play a pivotal role in pathophysiology of postoperative infection, and that circulating Hsp70 and blood loss may represent a prognostic marker for postoperative organ dysfunction.
Kimura
Fumio
F
Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670 Japan. kimura-f@umin.ac.jp
Itoh
Hiroshi
H
Ambiru
Satoshi
S
Shimizu
Hiroaki
H
Togawa
Akira
A
Yoshidome
Hiroyuki
H
Ohtsuka
Masayuki
M
Shimamura
Fumihiko
F
Kato
Atsushi
A
Nukui
Yuji
Y
Miyazaki
Masaru
M
D000368:Aged; D016063:Blood Loss, Surgical; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006498:Hepatectomy; D006801:Humans; D007239:Infections / Q000097:blood* / Q000503:physiopathology; D015850:Interleukin-6 / Q000097:blood; D007902:Length of Stay / Q000706:statistics & numerical data; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000503:physiopathology; D013997:Time Factors
D018840:HSP70 Heat-Shock Proteins; D015850:Interleukin-6