[Immunotropic properties of the causative agent of viral hepatitis C].
In this review the immunomodulating properties of the causative agent of viral hepatitis C are characterized on the basis of experimental data, obtained by Russian and foreign researchers during recent 3-5 years. The short characterization of the causative agent is presented and a number of adaptation mechanisms making it possible for hepatitis C virus to resist the action of the immune protective system of the host are considered. The role of individual protein products of the virus in the immunopathogenesis of the disease and the mechanisms of their action on the molecular level are discussed in detail on the basis of the results of mouse and in vitro experiments.
Kuramshin
D Kh
DKh
Institute of Clinical Immunology, Novosibirsk, Russia.
Sennikov
S V
SV
Kozlov
V A
VA
D000818:Animals; D004195:Disease Models, Animal; D016174:Hepacivirus / Q000276:immunology* / Q000472:pathogenicity; D006526:Hepatitis C / Q000276:immunology* / Q000821:virology; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis; D051379:Mice; D018345:Mice, Knockout; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism; D014774:Virulence
D014764:Viral Proteins; D007372:Interferons