[Antiretroviral therapy of acute HIV-infection].
OBJECTIVE
To study efficacy of a short course of highly active antiretroviral therapy (HAART).


METHODS
Acute HIV infection was verified in 16 infected subjected basing either on seroconversion (by immunoblotting) or a documented negative result 6-12 months before registration of a positive result for HIV antibodies.


RESULTS
HAART was given to 12 patients (combivir + nevirapin). The number of CD+ lymphocytes (by median) 1 month after the treatment increased by 185 cells/mcl, 3 months after the treatment--by 215 cells/mcl. After 1-month therapy viral load (median) diminished by 2.02 log10 copy/ml, after 3 months--by 2.31 log10 copy/ml. 71% patients had HIV RNA under 400 copy/ml. Untreated patients showed changes neither in CD4+ lymphocytes number nor in viral load. The study continues.


CONCLUSIONS
HAART is used at the stage of acute infection in the presence of psychic trauma provoked by establishment of HIV-infection diagnosis. Therefore, it is necessary to consult the patients for preparing them for treatment and to maintain compliance.
Kravchenko
A V
AV
Miroshnichenko
A V
AV
Beliaeva
V V
VV
Serebrovskaia
L V
LV
Bogoslovskaia
E V
EV
Sitdykova
Iu R
IuR
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D004338:Drug Combinations; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000523:psychology; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D018655:Lymphocyte Count; D008297:Male; D019829:Nevirapine / Q000008:administration & dosage*; D019562:Viral Load; D015215:Zidovudine / Q000008:administration & dosage*
D019380:Anti-HIV Agents; D004338:Drug Combinations; C109078:lamivudine, zidovudine drug combination; D019259:Lamivudine; D015215:Zidovudine; D019829:Nevirapine