title: Failure of valacyclovir for herpes zoster in a moderately immunocompromised HIV-infected patient.
abstract: Whereas valacyclovir is widely used and is recommended by some authors in moderately immunocompromised HIV-infected patients, its use has not been validated by clinical studies. We report a case of herpes zoster in an HIV-infected patient for whom neurologic complication was not avoided despite valacyclovir therapy. Clinical outcome was favorable after intravenous acyclovir. This case suggests careful monitoring of valacyclovir in HIV-infected patients is necessary.
authors.affiliation: Department of Infectious and Tropical Diseases Bichat Claude Bernard Hospital, Paris, France. guillaume.breton@bch.ap-hop-paris.fr
authors.forename: G
authors.initials: G
authors.lastname: Breton
authors.forename: M A
authors.initials: MA
authors.lastname: Bouldouyre
authors.forename: A
authors.initials: A
authors.lastname: Gervais
authors.forename: X
authors.initials: X
authors.lastname: Duval
authors.forename: P
authors.initials: P
authors.lastname: Longuet
authors.forename: C
authors.initials: C
authors.lastname: Leport
authors.forename: J L
authors.initials: JL
authors.lastname: Vildé
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D000212:Acyclovir / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D016903:Drug Monitoring; D004576:Electromyography; D006562:Herpes Zoster / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011843:Radiculopathy / Q000175:diagnosis / Q000821:virology; D017211:Treatment Failure; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir