Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies.
The authors report the presence of high titer antibodies to glutamic acid decarboxylase (anti-GAD65) until age 24 months in two asymptomatic newborns of a woman with stiff-person syndrome (SPS). No signs of SPS were detectable in the two children at ages 6 and 8 years. This observation indicates that other cofactors are involved in the pathogenesis of SPS.
Nemni
R
R
Department of Neurological Rehabilitation, Don C. Gnocchi Foundation, University of Milan, Italy. raffaello.nemni@unimi.it
Caniatti
L M
LM
Gironi
M
M
Bazzigaluppi
E
E
De Grandis
D
D
D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D007527:Isoenzymes / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D016750:Stiff-Person Syndrome / Q000276:immunology*; D013997:Time Factors
D001323:Autoantibodies; D001324:Autoantigens; D007518:Isoantibodies; D007527:Isoenzymes; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2