Phenolic and furan type compounds isolated from Gastrodia elata and their anti-platelet effects.
Nine phenolic (1-9) and two furan type (10, 11) compounds, were isolated from the methanolic extract of the tuber of Gastrodia elata Blume (Orchidaceae) in the course of continuing search for platelet anti-aggregating plant components. Compound 1 was identified as 4,4'-dihydroxybenzyl sulfone, a novel compound for the best of our knowledge. Compound 10, 5-hydroxymethyl-2-furancarboxaldehyde, was isolated for the first time from this plant. Compound 1 (IC50; 83 microM) was about four times more inhibitory to U46619 induced aggregation than ASA (IC50; 340 microM). Compound 9, 4,4'-dihydroxy-dibenzylether, (IC50; 5 microM, 3 microM and 33 microM, respectively) was 10-80 fold more potent than ASA (IC50; 420 microM, 53 microM and 340 microM respectively) to collagen, epinephrine and U46619 induced aggregation, although it is less active than ASA to AA induced aggregation.
Pyo
Mi Kyung
MK
Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
Jin
Jing Ling
JL
Koo
Yean Kyoung
YK
Yun-Choi
Hye Sook
HS
D000818:Animals; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031668:Gastrodia; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035281:Plant Tubers; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
D005663:Furans; D010636:Phenols; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors