title: In vivo measurement of the local optical properties of tissue by use of differential path-length spectroscopy.
abstract: We demonstrate the capability of differential path-length spectroscopy (DPS) to determine the local optical properties of tissue in vivo. DPS measurements on bronchial mucosa are analyzed and yield information on the local blood oxygenation, blood content, average microvessel diameter, and wavelength dependence of the reduced scattering coefficient. Our data collected to date show that cancerous bronchial mucosa has a lower capillary oxygenation and a larger average capillary diameter than normal bronchial mucosa.
authors.affiliation: Department of Radiation Oncology, Erasmus Medical Centre, P.O. Box 5201, 3008 AE Rotterdam, The Netherlands. a.amelink@erasmusmc.nl
authors.forename: Arjen
authors.initials: A
authors.lastname: Amelink
authors.forename: Henricus J C M
authors.initials: HJ
authors.lastname: Sterenborg
authors.forename: Martin P L
authors.initials: MP
authors.lastname: Bard
authors.forename: Sjaak A
authors.initials: SA
authors.lastname: Burgers
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D001984:Bronchial Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005240:Feasibility Studies; D005336:Fiber Optic Technology / Q000295:instrumentation; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D020545:Respiratory Mucosa / Q000473:pathology*; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*; D041622:Tomography, Optical / Q000295:instrumentation / Q000379:methods*