Regulating actin dynamics at membranes: a focus on dynamin.
Dynamin, the large guanosine triphosphatase, is generally considered to have a key role in deforming membranes to create tubules or vesicles. Dynamin, particularly dynamin2 isoforms, also are localized with actin filaments, often at locations where cellular membranes undergo remodeling. Perturbing dynamin function interferes with endocytic traffic and actin function. Thus, dynamin may regulate actin filaments coordinately with its activities that remodel membranes. This review will highlight recent observations that provide clues to mechanisms whereby dynamin might coordinate membrane remodeling and actin filament dynamics during endocytic traffic, cell morphogenesis and cell migration.
Schafer
Dorothy A
DA
Department of Biology, University of Virginia, Charlottesville, VA 22904, USA. das9w@virginia.edu
D000199:Actins / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement; D034281:Dynamins / Q000502:physiology*; D004705:Endocytosis; D006801:Humans; D020033:Protein Isoforms; D017434:Protein Structure, Tertiary
D000199:Actins; D020033:Protein Isoforms; D034281:Dynamins