title: 2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.
abstract: A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to highly potent Na+ channel blockers.
authors.affiliation: Ipsen Research Laboratories, Institut Henri Beaufour, 5 avenue du Canada, 91966 Les Ulis, France. anne-marie.liberatore@ipsen.com
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Liberatore
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Schulz
authors.forename: Jacques
authors.initials: J
authors.lastname: Pommier
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Barthelemy
authors.forename: Marion
authors.initials: M
authors.lastname: Huchet
authors.forename: Pierre-Etienne
authors.initials: PE
authors.lastname: Chabrier
authors.forename: Dennis
authors.initials: D
authors.lastname: Bigg
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D002243:Carbolines / Q000737:chemistry; D002478:Cells, Cultured; D004594:Electrophysiology; D020128:Inhibitory Concentration 50; D051381:Rats; D026941:Sodium Channel Blockers / Q000138:chemical synthesis* / Q000494:pharmacology; D015222:Sodium Channels / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014701:Veratridine / Q000494:pharmacology
chemical_list: D001562:Benzimidazoles; D002243:Carbolines; D026941:Sodium Channel Blockers; D015222:Sodium Channels; D014701:Veratridine