title: Microbeam developments and applications: a low linear energy transfer perspective.
abstract: In the last few years there has been a significant increase in the number of centers having, or developing, both high- and low-linear energy transfer (LET) microbeams for radiobiological investigations. In this review, we will discuss the various approaches for developing low-LET single cell irradiation devices and consider the instrument designs and how the machines capabilities can be exploited to investigate targeted and non-targeted effects of low-LET irradiation.
authors.affiliation: Chemistry and Physics of Complex Systems, Pacific Northwest National Laboratory, MS K8-88, 3335 Q Ave, Richland, WA 99352, USA. marianne.sowa-resat@pnl.gov
authors.forename: Marianne
authors.initials: M
authors.lastname: Sowa Resat
authors.forename: William F
authors.initials: WF
authors.lastname: Morgan
mesh_terms: D004583:Electrons; D006801:Humans; D018499:Linear Energy Transfer; D011522:Protons; D011853:Radiobiology / Q000295:instrumentation*; D014965:X-Rays
chemical_list: D011522:Protons