title: [A study on the inhibiting effects of transforming growth factor-beta R II antibody on fibroblasts].
abstract: OBJECTIVE
  To investigate the inhibiting action of transforming growth factor-beta type R II receptor(TGF-beta R II) antibody to fibroblasts.
  
  
  METHODS
  Four groups of cultured skin fibroblasts were treated with different dosages of TGF-beta R II antibody. Examinations were performed with HYP, MTT, microscope, and flow cytometry techniques.
  
  
  RESULTS
  TGF-beta R II antibody resulted in significant inhibition of fibroblasts(P < 0.01).
  
  
  CONCLUSIONS
  TGF-beta R II antibody has inhibiting effects on the proliferation of skin fibroblasts and with a dose-dependent manner.
authors.affiliation: Plastic Surgery Hospital of Chinese Academy of Medical Sciences, Beijing 100041, China.
authors.forename: Yu-zhu
authors.initials: YZ
authors.lastname: Quan
authors.forename: Hong-xing
authors.initials: HX
authors.lastname: Zhuang
authors.forename: Qing-guo
authors.initials: QG
authors.lastname: Zhang
authors.forename: Yong-cheng
authors.initials: YC
authors.lastname: Leng
authors.forename: Juan
authors.initials: J
authors.lastname: Hang
authors.forename: Yan-yong
authors.initials: YY
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D005434:Flow Cytometry; D006801:Humans; D008854:Microscopy, Electron; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II