title: Studies on pyridazine azide cyclisation reactions.
abstract: Reaction of sodium azide with 4-methyl-3,5,6-tribromopyridazine results in the formation of 3,5,6-triazide intermediate which could cyclise to give two possible bicyclic products while ab initio calculations show that the formation of a tricyclic compound is extremely energetically unfavourable. However, experimentally, only one major product is isolated. The structure of this unstable product has been conclusively established by X-ray crystallography as 3,5-diazido-4-methyl[1,5-b]tetrazolopyridazine confirming theoretical predictions.
authors.affiliation: Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, The University of Sydney, NSW, Australia. r_allan@pharmacol.usyd.edu.au
authors.forename: Robin D
authors.initials: RD
authors.lastname: Allan
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Greenwood
authors.forename: Trevor W
authors.initials: TW
authors.lastname: Hambley
authors.forename: Jane R
authors.initials: JR
authors.lastname: Hanrahan
authors.forename: David E
authors.initials: DE
authors.lastname: Hibbs
authors.forename: Samia
authors.initials: S
authors.lastname: Itani
authors.forename: Hue W
authors.initials: HW
authors.lastname: Tran
authors.forename: Peter
authors.initials: P
authors.lastname: Turner