title: Progress on new vaccine strategies for the immunotherapy and prevention of cancer.
abstract: In recent years, great strides in understanding and regulating the immune system have led to new hope for harnessing its exquisite specificity to destroy cancer cells without affecting normal tissues. This review examines the fundamental immunologic advances and the novel vaccine strategies arising from these advances, as well as the early clinical trials studying new approaches to treat or prevent cancer.
authors.affiliation: Molecular Immunogenetics and Vaccine Research Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. berzofsk@helix.nih.gov
authors.forename: Jay A
authors.initials: JA
authors.lastname: Berzofsky
authors.forename: Masaki
authors.initials: M
authors.lastname: Terabe
authors.forename: SangKon
authors.initials: S
authors.lastname: Oh
authors.forename: Igor M
authors.initials: IM
authors.lastname: Belyakov
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Ahlers
authors.forename: John E
authors.initials: JE
authors.lastname: Janik
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
mesh_terms: D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology / Q000494:pharmacology*; D005822:Genetic Vectors; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*; D019444:Vaccines, DNA / Q000276:immunology / Q000494:pharmacology; D022223:Vaccines, Subunit / Q000276:immunology; D014780:Viruses
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D019444:Vaccines, DNA; D022223:Vaccines, Subunit