Pharmacokinetics of indinavir in Koreans and Caucasians.
We evaluated whether the pharmacokinetic parameters of indinavir differ in Koreans and Caucasians. Indinavir was administered orally to 8 healthy Koreans and 4 healthy Caucasians, and plasma indinavir levels were quantified by high performance liquid chromatography. No significant differences were observed in terms of its pharmacokinetic parameters; however, the AUC difference between the 2 groups may be significant for larger sample sizes.
Choi
Jun Yong
JY
Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Chang
Kyung Hee
KH
Park
Yoon Soo
YS
Cho
Cheong Ho
CH
Shin
So Youn
SY
Song
Young Goo
YG
Kim
June Myung
JM
D000328:Adult; D019540:Area Under Curve; D044466:Asian People; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D044465:White People
D017320:HIV Protease Inhibitors; D019469:Indinavir