Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge.
Allergen specific nasal challenge (ASNC) is an optimal model to study the pathophysiological mechanisms sustaining allergic inflammation, particularly the cytokine pattern. Antihistamines have been accepted as a highly effective therapy for allergic rhinitis. The aim of this double blind, randomised, placebo controlled study was the evaluation of symptoms and cytokines, during the early phase, after a single dose of mizolastine (10 mg), fexofenadine (120 mg) or placebo, using the model of ASNC. A total of 30 patients with allergic rhinitis underwent nasal challenge 6 hours after treatment. The following parameters were evaluated 30 minutes after ASNC (i.e. early phase): nasal symptoms (rhinorrhea, itching, sneezing, obstruction), and cytokine pattern, including IL1, IL6, and TNFalpha. Mizolastine was associated with early phase reduction of: i) clinical symptoms (p < 0.03), ii) cyotkine levels of IL1 (p = 0.003), IL6 (p < 0.007), and TNF_ (p < 0.003) in comparison with placebo group. Fexofenadine significantly inhibited IL6 (p < 0.004) and TNFalpha (p < 0.004) levels in comparison with placebo. The present findings demonstrate that mizolastine exerts a significant effect on early phase events, reducing symptoms and pro-inflammatory cytokines. Fexofenadine reduces TNFalpha and IL6 levels only. These effects appear to be clinical relevant for mizolastine.
Ciprandi
Giorgio
G
San Martino Hospital, Genoa, Italy.
Cirillo
Ignazio
I
Vizzaccaro
Andrea
A
D000328:Adult; D000485:Allergens; D018926:Anti-Allergic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D003233:Conjunctivitis, Allergic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D016207:Cytokines / Q000097:blood*; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009299:Nasal Provocation Tests; D032403:Parietaria; D011058:Pollen; D006255:Rhinitis, Allergic, Seasonal / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D012720:Severity of Illness Index; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000485:Allergens; D018926:Anti-Allergic Agents; D001562:Benzimidazoles; D016207:Cytokines; D006634:Histamine H1 Antagonists; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; C076170:mizolastine; D016593:Terfenadine; C093230:fexofenadine