Samarium diiodide coupling of enones: a remarkable cascade sequence.
[reaction: see text] Treatment of cyclic enones with SmI(2) in THF/MeOH (4:1) led to tricyclic diol products in one step and, in the case of enone 7, gave the tetracycle 13 as a single diastereoisomer in up to 67% yield.
Howells
Dean M
DM
School of Chemistry, University of Southampton, Southampton, UK SO17 1BJ.
Barker
Sarah M
SM
Watson
Faye C
FC
Light
Mark E
ME
Hursthouse
Michael B
MB
Kilburn
Jeremy D
JD