Hyaline-vascular variant of Castleman's disease mimicking a gastric submucosal tumor.
Castleman's disease is a rare lymphoproliferative disorder with unknown underlying cause. Three histologic variants (hyaline-vascular, plasma cell and mixed) as well as 2 clinical groups (localized and multicentic) have been described. Most patients with the hyaline-vascular variant are asymptomatic other than localized pressure from the mass. Hyaline-vascular Castleman's disease was commonly found as intrathoracic presentation. Extrathoracic lesions have been reported in the retroperitoneum, mesentery, central nervous system, orbit, pelvis, neck, axilla, and skeletal muscles. Herein, we report a case of hyaline-vascular Castleman's disease mimicking a gastric submucosal leiomyoma that has rarely been reported in English literature review. The lesion was not actually developing from the stomach, however, the clinical presentation was mimicking a submucosal gastric tumor. Furthermore, the patient in this case had both chronic hepatitis C and splenosis. The relationship between the underlying diseases and the development of the CD deserves further investigations.
Chou
Shih-Pin
SP
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwvan, ROC.
Chen
Liang-Kung
LK
Lo
Su-Shun
SS
Li
Anna Fen-Yao
AF
Chang
Feng-Chi
FC
Hwang
Shinn-Jang
SJ
D005871:Castleman Disease / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013154:Spleen / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology