Synthesis of a bioprobe for elucidation of target molecule of spongean anti-malarial peroxides.
The reactants of an anti-malarial peroxide having a 6-carbomethoxymethyl-3-methoxy-1,2-dioxane moiety treated with FeSO4 were analyzed. For mechanistic study of the anti-malarial peroxide, two biotinylated probes to elucidate the target molecules were designed and synthesized. The two synthesized probes showed potent anti-malarial activity, and one of them was proved to form an irreversible binding with protein in a model experiment.
Murakami
Nobutoshi
N
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Kawanishi
Motoyuki
M
Itagaki
Sawako
S
Horii
Toshihiro
T
Kobayashi
Motomasa
M
D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D015374:Biosensing Techniques; D004146:Dioxanes / Q000138:chemical synthesis / Q000494:pharmacology; D015195:Drug Design; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008954:Models, Biological; D008956:Models, Chemical; D010545:Peroxides / Q000138:chemical synthesis* / Q000494:pharmacology; D011485:Protein Binding; D013997:Time Factors
D000962:Antimalarials; D004146:Dioxanes; D005296:Ferrous Compounds; D010545:Peroxides; C020748:ferrous sulfate