title: Propofol sedation using Diprifusor target-controlled infusion in adult intensive care unit patients.
abstract: This multicentre, non-comparative study investigated the range of target blood propofol concentrations required to sedate 122 adult intensive care patients when propofol was administered using Diprifusor target-controlled infusion systems together with opioid analgesia. Depth of sedation was assessed with a modified Ramsay score and the target blood propofol setting was adjusted to achieve the sedation desired for each patient. A desired level of sedation was achieved for 84% of the sedation period. In postcardiac surgery patients the median time-weighted average propofol target setting was 1.34 microg.ml(-1) (10th - 90th percentiles: 0.79-1.93 microg.ml(-1)). Values in brain injured and general ICU patients were 0.98 (10th - 90th percentiles: 0.60-2.55) microg.ml(-1) and 0.42 (10th - 90th percentiles: 0.16-1.19) microg.ml(-1), respectively. Measured propofol concentrations were generally close to values predicted by the Diprifusor system. Target settings in the range of 0.2-2.0 microg.ml(-1) are proposed for propofol sedation in this setting with titration as required in individual patients.
authors.affiliation: Royal Victoria Hospital, Belfast, UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: McMurray
authors.forename: J R
authors.initials: JR
authors.lastname: Johnston
authors.forename: K R
authors.initials: KR
authors.lastname: Milligan
authors.forename: I S
authors.initials: IS
authors.lastname: Grant
authors.forename: S J
authors.initials: SJ
authors.lastname: Mackenzie
authors.forename: F
authors.initials: F
authors.lastname: Servin
authors.forename: G
authors.initials: G
authors.lastname: Janvier
authors.forename: J B
authors.initials: JB
authors.lastname: Glen
mesh_terms: D000328:Adult; D000368:Aged; D016292:Procedural Sedation / Q000379:methods*; D003422:Critical Care / Q000379:methods; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000097:blood; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care / Q000379:methods; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol