Wnt signaling: Ig-norrin the dogma.
Secreted Wnt proteins trigger the intracellular Wnt signaling cascade upon engagement of dedicated Frizzled-Lrp receptor complexes. Unexpectedly, a non-Wnt ligand for this receptor complex has now been discovered. This novel ligand, Norrin, is mutated in the hereditary ocular Norrie syndrome.
Clevers
Hans
H
Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. clevers@niob.knaw.nl
D001766:Blindness / Q000235:genetics*; D005109:Extracellular Matrix / Q000378:metabolism; D051157:Frizzled Receptors; D006801:Humans; D026502:LDL-Receptor Related Proteins; D008024:Ligands; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D009154:Mutation / Q000235:genetics; D011506:Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D011973:Receptors, LDL / Q000378:metabolism; D015398:Signal Transduction
C402930:FZD4 protein, human; D051157:Frizzled Receptors; D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; C555475:LRP6 protein, human; D008024:Ligands; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D060488:Low Density Lipoprotein Receptor-Related Protein-6; D011506:Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D011973:Receptors, LDL