[Immunological up-regulation of cyclophosphamide-treated mice by turtle blood extract].
OBJECTIVE
To explore the effect of turtle blood extract on murine immune system.


METHODS
We compared the ratio of CD4(+) helper T cells and CD8(+) T cells, NK cell activity, lymphocyte proliferation stimulated by mitogen and capability of cytokine secretion of cyclosphophamide-treated mice with or without treatment of turtle blood extract.


RESULTS
Turtle blood extract-treated mice displayed increased CD4(+) helper T cell population, stronger cytotoxicity of NK cells and enhanced of ConA-induced lymphocyte proliferation. In addition, the capacity of IFN-gamma secretion was dramatically up-regulated in turtle blood extract-treated mice group.


CONCLUSIONS
Turtle blood extract can upregulate the immune function of cyclosphophamide-treated mouse.
Wang
Ying
Y
Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China. ywang@sibs.ac.cn
Zhang
Hui-zhen
HZ
Wang
Shu-jun
SJ
Zhang
Yong
Y
Shen
Tian-wei
TW
Chen
Guang-jie
GJ
Ge
Hai-liang
HL
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014426:Turtles / Q000097:blood*; D015854:Up-Regulation
D000276:Adjuvants, Immunologic; D003520:Cyclophosphamide