(+)-3-[2-(Benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane as potent agonists for the alpha7 nicotinic acetylcholine receptor.
A series of 3-substituted 1-azabicyclo[2.2.2]octanes was discovered as the alpha7 nicotinic acetylcholine (alpha7) receptor agonists. It was found that (+)-3-[2-(benzo[b]thiophen-2-yl)-2-oxoethyl]-1-azabicyclo[2.2.2]octane (+)-15b has potent agonistic activity for the alpha7 receptor.
Tatsumi
Ryo
R
Pharmaceuticals Research Unit, Research and Development Division, Mitsubishi Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0023, Japan. Tatsumi.Ryo@mg.m-pharma.co.jp
Seio
Kohji
K
Fujio
Masakazu
M
Katayama
Jiro
J
Horikawa
Takashi
T
Hashimoto
Kenji
K
Tanaka
Hiroshi
H
D000818:Animals; D001372:Aza Compounds / Q000737:chemistry; D001665:Binding Sites; D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D008956:Models, Chemical; D018722:Nicotinic Agonists / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D009795:Octanes / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D016716:PC12 Cells / Q000187:drug effects; D051381:Rats; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013876:Thiophenes / Q000737:chemistry; D064569:alpha7 Nicotinic Acetylcholine Receptor
D001372:Aza Compounds; D001643:Bridged Bicyclo Compounds; C579165:Chrna7 protein, rat; D018722:Nicotinic Agonists; D009795:Octanes; D011978:Receptors, Nicotinic; D013876:Thiophenes; D064569:alpha7 Nicotinic Acetylcholine Receptor