Central nervous system infection due to Penicillium chrysogenum.
Penicillium chrysogenum was isolated from three subsequent cerebrospinal fluid (CSF) specimens of a 73-year-old male patient without immunological compromise. The isolated was tested against five antifungal agents according to the NCCLS M38-P macrodilution method. MICs were determined as follows: amphotericin B (AMB), 2 microg ml(-1); fluconazole (FLZ), 8 microg ml(-1); itraconazole (ITZ), 1 microg ml(-1); flucytosine (5FC), 0.125 microg ml(-1); and terbinafine (TRB), 0.06 microg ml(-1). The patient has been cured with FLZ.
Kantarcioğlu
A S
AS
Cerrahpasa Medical Faculty, Department of Microbiology and Clinical Microbiology, Istanbul University, Istanbul, Turkey. s.kantarcioglu@superonline.com
Apaydin
H
H
Yücel
A
A
de Hoog
G S
GS
Samson
R A
RA
Vural
M
M
Ozekmekçi
S
S
D000368:Aged; D002494:Central Nervous System Infections / Q000188:drug therapy / Q000382:microbiology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D006801:Humans; D008297:Male; D010408:Penicillium chrysogenum / Q000187:drug effects / Q000302:isolation & purification*