[Effect of damages of capsaicin-sensitive nerves on alpha1-antitrypsin activity in the rat blood].
Systemic administration of capsaicin (a neurotoxin of afferent nerves) in a dose of 150 mg/kg led to a decrease in the activity of alpha 1-antitrypsin (alpha 1-AT) in the blood of male Wistar rats. This effect is related to impairment of the local effector function of capsaicin-sensitive nerves in the liver, which is the main source of alpha 1-AT in the blood. Analogous results were obtained upon cutting of the hepatic branch of the vagus nerve involving capsaicin-sensitive afferent fibers of the liver.
Tolochko
Z S
ZS
Laboratory of Functional Neuromorphology, Institute of Physiology, Siberian Division, Russian Academy of Medical Sciences, ul. Timakova, 4, Novosibirsk, 630117 Russia.
Spiridonov
V K
VK
D000818:Animals; D001769:Blood; D002211:Capsaicin / Q000494:pharmacology*; D003714:Denervation; D008099:Liver / Q000294:innervation; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D000515:alpha 1-Antitrypsin; D002211:Capsaicin