title: Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N'-arylthiourea inhibitors of CMV.
abstract: A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM.
authors.affiliation: Chemical and Screening Sciences and Infectious Disease Research, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. bloomj@wyeth.com
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Bloom
authors.forename: Russell G
authors.initials: RG
authors.lastname: Dushin
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Curran
authors.forename: Fran
authors.initials: F
authors.lastname: Donahue
authors.forename: Emily B
authors.initials: EB
authors.lastname: Norton
authors.forename: Eugene
authors.initials: E
authors.lastname: Terefenko
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Jones
authors.forename: Adma A
authors.initials: AA
authors.lastname: Ross
authors.forename: Boris
authors.initials: B
authors.lastname: Feld
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Lang
authors.forename: Martin J
authors.initials: MJ
authors.lastname: DiGrandi
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D006564:Herpesviridae / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D013890:Thiourea