[Alleles of HLA class II DRB1 of patients with essential hypertension in Yunnan Hans].
OBJECTIVE
To investigate the association between the alleles of human leukocyte antigens (HLA)-DRB1 and essential hypertension (EH) in the Hans living in Yunnan of China.


METHODS
The alleles of HLA-DRB1 were typed by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in samples from 83 patients with essential hypertension and 91 healthy controls. All of the subjects, their grandparents and grand-grandparents are Hans living in Yunnan of China.


RESULTS
The frequency of DRB1*1501/2 in the EH patients (0.219) was significantly higher than that in the controls(0.060), chi quare=18.331, P<0.01. Relative risk (RR) was 4.46, and etiologic factor (EF) was 0.34. The frequency of DRB1*0901 significantly decreased in the group of patients with EH in comparison to the controls (0.081 versus 0.192)  chi-square=8.704  P<0.05. RR was 0.41 and prevention factor(PF) was 0.19.


CONCLUSIONS
HLA-DRB1*1501/2 is associated with the susceptibility to essential hypertension in the Yunnan Hans of China. DRB1*0901 may protect one from the disease.
Shao
Jian-chun
JC
Key Laboratory of Disease Molecule Biochemistry in Kunming, the First People's Hospital of Kunming, Kunming, Yunnan, 650011 PR China. shaojchua@hotmail.com
Hu
Da-chun
DC
Chen
Ai-hua
AH
Wang
Wei
W
Chen
Jun
J
Sun
Bao-ming
BM
Cai
Xue-mei
XM
D000328:Adult; D000368:Aged; D000483:Alleles; D002681:China / Q000208:ethnology; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains