Intraoperative optical imaging of human face cortical topography: a case study.
We used intrinsic signal optical imaging to obtain maps of human somatosensory cortex during electrocutaneous stimulation of the face during a neurosurgical procedure for epilepsy. We found that human face somatotopy is organized like the macaque or cebus monkey, with peri-orbital skin located medial to peri-buccal skin, and that cortical magnification in the human is comparable to that in non-human primates. This study demonstrates that intrinsic signal imaging can be performed on humans during operative procedures with sufficient spatial resolution to reveal high-resolution topographic maps.
Schwartz
Theodore H
TH
Department of Neurosurgery,Yale University School of Medicine, New Haven, CT, USA. schwarh@med.cornell.edu
Chen
Li Min
LM
Friedman
Robert M
RM
Spencer
Dennis D
DD
Roe
Anna W
AW
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D004827:Epilepsy / Q000601:surgery*; D005145:Face / Q000294:innervation*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D019635:Neurosurgical Procedures; D013003:Somatosensory Cortex / Q000502:physiology*