Genetic characteristics and population study of 4 X-chromosomal STRs in Koreans: evidence for a null allele at DXS9898.
The four X-chromosomal short tandem repeats (STRs), DXS9898, DXS6809, DXS7424 and DXS10011 were analyzed by single multiplex PCR in 150 male and 150 female Koreans. The loss of an allele at DXS9898 was observed in 13 out of 450 chromosomes (2.9%) and the PCR analysis showed that the X-chromosome with a null allele at DXS9898 has more than 1 kb deletion at the DXS9898 locus. Statistical analyses for these four X-STRs showed that they are highly informative for forensic application in Koreans. No linkage disequilibrium was observed among these four STRs and the previously reported five polymorphic STRs, HumARA, DXS101, GATA172D05, HPRTB and DXS8377 in Koreans. The test of homogeneity between allele frequencies revealed that there are some discrepancies in allele distributions between Koreans and Germans.
Lee
Hwan Young
HY
Department of Forensic Medicine, College of Medicine, Yonsei University, 134 Shinchon-Dong, Seodaemun-Gu, 120-752 Seoul, Korea.
Park
Myung Jin
MJ
Jeong
Chan Kwon
CK
Lee
Seon Yeong
SY
Yoo
Ji-Eun
JE
Chung
Ukhee
U
Choi
Jong-Hoon
JH
Kim
Chong-Youl
CY
Shin
Kyoung-Jin
KJ
D041321:Chromosomes, Human, X / Q000235:genetics*; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium; D019656:Loss of Heterozygosity; D008297:Male; D020080:Tandem Repeat Sequences / Q000235:genetics*