[Relationship of oncogene C-erbB2 expression to ER, PR and PS2 in breast cancer and its prognostic significance].
OBJECTIVE
To explore the expression of oncogene C-erbB2 in breast cancer, its relationship to estrogen receptor (ER), progesterone receptor (PR) and PS2 and the prognostic significance.


METHODS
The expression of oncogene C-erbB2 in 245 cases with breast cancer was detected with immunohistochemical technique (LsAB).


RESULTS
Expression of oncogene C-erbB2 was found in 60% cases of breast cancer. Tumors positive for C-erbB2 were 45.19% and 71.55% in ER positive group and ER negative group respectively, while tumors positive for C-erbB2 were 48.08% and 70.43% in PR positive group and PR negative group respectively. The expression of the C-erbB2 was 23.26% in group of PS2 positive and 50.75% in group of PS2 negative (P < 0.05). No significant association of C-erbB2 expression with age and tumor size was noted(P > 0.05), but its expression in breast cancer was correlated with advanced clinical stage, high histological grade, axillary lymph node involvement (P < 0.05).


CONCLUSIONS
C-erbB2 would be helpful to the evaluation of prognosis and treatment in breast cancer.
Yang
Jin-qiao
JQ
Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Chen
Lin
L
Xing
Tian-yong
TY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone