[Effectiveness of omeprazole therapy in children with gastroesophageal reflux diseases(GERD)].
OBJECTIVE
Of the study was retrospective analysis of omeprazole (Polprazol) therapy efficacy in children with GERD.


METHODS
The analyzed group consisted of 78 children with gastroesophageal reflux disease. GERD was detected on the base of questionnaire, pH-metry and/or endoscopy. The questionnaire was conducted in all patients, 24-hour pH-metric examination in 47% and endoscopy in 53% children. Than omeprazole therapy was introduced (0.5-1.0 mg/kg daily).


RESULTS
Before omeprazole therapy rebounding was observed in 94% children, heartburn in 84%, vomits in 38% and abdominal pain in 90% children. After 8 weeks of therapy analyzed symptoms were significantly reduced--rebounding was observed in 31% children, heartburn in 28% vomits in 5% and abdominal pain in 26% children.


CONCLUSIONS
Omeprazole therapy is effective in children with gastroesophageal reflux disease.
Czerwionka-Szaflarska
Mieczysława
M
Katedra i Klinika Pediatrii, Alergologii i Gastroenterologii Akademii Medycznej w Bydgoszczy.
Mierzwa
Grazyna
G
Kuczyńska
Renata
R
D000293:Adolescent; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005764:Gastroesophageal Reflux / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography
D000897:Anti-Ulcer Agents; D009853:Omeprazole