title: [Respiratory distress syndrome induced by immersion in seawater: a study of canine models].
abstract: OBJECTIVE
  To study the mechanism of respiratory distress syndrome (RDS) induced by immersion in seawater to provide experimental evidence for its treatment.
  
  
  METHODS
  Twelve normal hybrid dogs were randomly assigned into control group (n=4) and SDS model group (n=8). The changes in blood dynamics, blood gas analysis and histological changes in the lung tissues were compared between the 2 groups. The concentration of lactic dehydrogenase (LDH-L) and alkaline phosphatase (ALP) in the bronchoalveolar fluid and blood of the dogs in the model group were tested.
  
  
  RESULTS
  The blood dynamics, blood gas analysis and histology of the dogs in the model group were significantly different from those in the control group, and LDH-L and ALP levels increased significantly in the bronchoalveolar fluid of the model group.
  
  
  CONCLUSIONS
  Seawater aspiration into the lungs may lead to RDS, and the canine models used in this study may help explore the mechanism and management of RDS induced by immersion in seawater.
authors.affiliation: SICU Seawater Research Team, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Fu
authors.forename: Miao-ning
authors.initials: MN
authors.lastname: Gu
authors.forename: Zhong-qing
authors.initials: ZQ
authors.lastname: Chen
authors.forename: Jin-fang
authors.initials: JF
authors.lastname: Xiao
authors.forename: Yi-ran
authors.initials: YR
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Ye-ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007101:Immersion; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008168:Lung / Q000473:pathology; D008297:Male; D012128:Respiratory Distress Syndrome / Q000209:etiology* / Q000473:pathology; D012623:Seawater
chemical_list: D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase