Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation.
A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.
Hong
Sung-Yu
SY
College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea.
Chung
Kwang-Hoe
KH
You
Hea-Jung
HJ
Choi
Ik Hwa
IH
Chae
Mi Jin
MJ
Han
Ja-Young
JY
Jung
Ok-Jai
OJ
Kang
Soo-Jung
SJ
Ryu
Chung-Kyu
CK
D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects
D001562:Benzimidazoles; D006131:Growth Inhibitors; D010982:Platelet-Derived Growth Factor; D048031:JNK Mitogen-Activated Protein Kinases