Efficient catalysis of Nazarov cyclization using a cationic iridium complex possessing adjacent labile coordination sites.
The dicationic Ir(III) complex [IrMe(CO)(dppe)(DIB)](BARF)2 having adjacent labile sites has been found to be a very effective catalyst for promoting the Nazarov cyclization of aryl vinyl and divinyl ketones. Spectroscopic evidence for a substate-catalyst complex before cyclization is presented. The efficiency of the cyclization is attributed to the electrophilicity of the Ir(III) complex and substrate activation via chelation.
Janka
Mesfin
M
Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.
He
Wei
W
Frontier
Alison J
AJ
Eisenberg
Richard
R