Necrotizing enterocolitis: preventative strategies.
Necrotizing enterocolitis (NEC) remains a major cause of morbidity and mortality in premature infants. Although the pathogenesis of NEC is unclear, prevention strategies have been developed based on clinical observations and epidemiologic and experimental data. Most current strategies have centered on feeding practices (eg, institution of feeds, advancement of feeds, composition of feeds, and standardization of feeding practices). Emerging strategies include amino acid supplementation, the use of platelet-activating factor(PAF) antagonists or PAF-acetylhydrolase administration, polyunsaturated fatty acid administration, epidermal growth factor administration, and the use of pre- and probiotics.
Reber
Kristina M
KM
Division of Neonatology, Department of Pediatrics, The Ohio State University College of Medicine and Public Health and the Children's Research Institute, Children's Hospital, 700 Children's Drive, Columbus, Ohio 43205, USA. reberk@pediatrics.ohio-state.edu
Nankervis
Craig A
CA
D000284:Administration, Oral; D000596:Amino Acids / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019587:Dietary Supplements; D004374:Ductus Arteriosus, Patent / Q000517:prevention & control; D020345:Enterocolitis, Necrotizing / Q000517:prevention & control*; D005508:Food Deprivation; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D008895:Milk, Human; D011295:Prenatal Care; D011315:Preventive Medicine / Q000379:methods; D019936:Probiotics / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D007136:Immunoglobulins; D013256:Steroids