Drosophila development: RNA interference ab ovo.
A novel protein required for RNA interference in Drosophila, Armitage, was identified in a screen for genes involved in embryonic axis formation. In armitage mutants, oocyte polarity and the regulation of oskar mRNA translation are impaired, suggesting that RNA silencing regulates the first steps of Drosophila development.
Chekulaeva
Marina
M
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. chekulae@emble.de
Ephrussi
Anne
A
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D016764:Cell Polarity; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D009865:Oocytes / Q000166:cytology; D009866:Oogenesis / Q000502:physiology; D020365:RNA Helicases / Q000235:genetics*; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism; D034743:RNA-Induced Silencing Complex / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D034743:RNA-Induced Silencing Complex; C091675:osk protein, Drosophila; C484034:armi protein, Drosophila; D020365:RNA Helicases