title: Binding of transition metal ions [cobalt, copper, nickel and zinc] with furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-derived cephalexins as potent antibacterial agents.
abstract: A method is described for the preparation of novel cephalexin-derived furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-containing compounds showing potent antibacterial activity. The binding of these newly synthesized antibacterial agents with metal ions such as cobalt(II), copper(II), nickel(II) and zinc(II) has been studied and their inhibitory properties against various bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae are also reported. These results suggest that metal ions to possess an important role in the designing of metal-based antibacterials and that such complexes are more effective against infectious diseases compared to the uncomplexed drugs.
authors.affiliation: Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Zahid H
authors.initials: ZH
authors.lastname: Chohan
authors.forename: Humayun
authors.initials: H
authors.lastname: Pervez
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Rauf
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002506:Cephalexin / Q000737:chemistry / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D005663:Furans / Q000737:chemistry; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000737:chemistry; D010621:Phenazopyridine / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011758:Pyrroles / Q000737:chemistry; D012459:Salicylates / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D015032:Zinc / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D005663:Furans; D008670:Metals; D011758:Pyrroles; D012459:Salicylates; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc; D010621:Phenazopyridine; D002506:Cephalexin; C039281:furan