title: Factor V Leiden mutation in pregnancy.
abstract: Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations. Nurses should be knowledgeable about screening for and diagnosis of factor V Leiden mutation, risk reduction counseling, recommended care of the affected patient, and implications of anticoagulant therapy during the perinatal period.
authors.forename: Susan Murphy
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D020016:Activated Protein C Resistance / Q000235:genetics / Q000451:nursing; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D015404:Nursing Methodology Research; D009773:Obstetric Nursing / Q000592:standards; D010353:Patient Education as Topic / Q000379:methods; D017354:Point Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000451:nursing; D011250:Pregnancy Complications, Hematologic / Q000451:nursing; D011256:Pregnancy Outcome; D012307:Risk Factors; D013923:Thromboembolism / Q000235:genetics / Q000451:nursing; D020246:Venous Thrombosis / Q000235:genetics / Q000451:nursing
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V