title: Approximate equivalent rosuvastatin doses for temporary statin interchange programs.
abstract: OBJECTIVE
  To estimate approximate doses of rosuvastatin equivalent to the other hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) for a temporary substitution program.
  
  
  METHODS
  A literature search was conducted to locate clinical trials directly comparing rosuvastatin with other statins that evaluated the magnitude of cholesterol lowering.
  
  
  RESULTS
  The mean low-density lipoprotein and total cholesterol values from the clinical trials were assessed. Study results indicate that rosuvastatin is not equivalent to other statins on a milligram-to-milligram basis.
  
  
  CONCLUSIONS
  Rosuvastatin appears to be at least 2 and 4 times as potent as atorvastatin and simvastatin, respectively, and at least 8 times as potent as pravastatin and lovastatin.
authors.affiliation: Department of Pharmacy Practice; Samford University Global Drug Information Service, McWhorter School of Pharmacy, Samford University, Birmingham, AL 35229-7027, USA. mgkrendra@samford.edu
authors.forename: Michael G
authors.initials: MG
authors.lastname: Kendrach
authors.forename: Maisha
authors.initials: M
authors.lastname: Kelly-Freeman
mesh_terms: D002784:Cholesterol / Q000097:blood; D002986:Clinical Trials as Topic; D004347:Drug Interactions; D005464:Fluorobenzenes / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy; D008077:Lipoproteins, LDL / Q000097:blood; D011743:Pyrimidines / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D013810:Therapeutic Equivalency
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008077:Lipoproteins, LDL; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium; D002784:Cholesterol