title: The effects of 'supra-physiological' vitamin B12 administration on temporary threshold shift.
abstract: The aim of this study was to evaluate, in 20 young volunteer subjects, the effects of supra-physiological vitamin B12 administration on noise-induced temporary threshold shift (TTS). All subjects had hearing thresholds within 15 dBHL and type A tympanograms. The subjects were randomly assigned to two different groups. Experimental group subjects received cyanocobalamin, 1 mg daily for 7 days, and 5 mg on the eighth day. Control group subjects received a placebo injection daily for 8 days. The vitamin B12 concentration, hearing thresholds and TTS2 (10 min of exposure, narrowband noise centred at 3 kHz, bandwidth of 775 Hz, 112 dBSPL) were measured before and 8 days after treatment. At the end of treatment, the serum vitamin B12 concentration was significantly increased in the experimental group. After 8 days of treatment, the control group showed the same hearing thresholds and TTS2 degrees. Statistical analysis showed that TTS2 decreased significantly at 3 and 4kHz when cobalamin was used to increase the serum concentration of vitamin B12 to > 2350 pg/ml. In addition, a protective effect at 3 kHz in the experimental group was evident when compared with the placebo group. These results suggest that elevated plasma cyanocobalamin levels may reduce the risk of hearing dysfunction resulting from noise exposure in healthy, young subjects.
authors.affiliation: ENT Clinic 'G. Lugli', Department of Ophthalmology and Otorhinolaryngology, University of Bari, Bari, Italy. otorino1@orl.uniba.it
authors.forename: Antonio
authors.initials: A
authors.lastname: Quaranta
authors.forename: Angelo
authors.initials: A
authors.lastname: Scaringi
authors.forename: Roberto
authors.initials: R
authors.lastname: Bartoli
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Margarito
authors.forename: Nicola
authors.initials: N
authors.lastname: Quaranta
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects* / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D006317:Hearing Loss, Noise-Induced / Q000517:prevention & control*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009622:Noise / Q000009:adverse effects*; D014805:Vitamin B 12 / Q000008:administration & dosage* / Q000097:blood
chemical_list: D014805:Vitamin B 12