Putting the squeeze on mechanotransduction.
Both mechanical and chemical stimuli guide tissue function. In a recent paper, Tschumperlin et al. proposed that pressure acting on airway epithelium elicits mechanotransduction not by directly altering biochemical signaling but by regulating extracellular fluid volume to modulate ligand-receptor interactions.
Helmke
Brian P
BP
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA22908, USA.
Schwartz
Martin A
MA
D000399:Air Pressure; D000818:Animals; D019898:Autocrine Communication / Q000502:physiology; D045604:Extracellular Fluid / Q000502:physiology; D006801:Humans; D008024:Ligands; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000502:physiology; D020545:Respiratory Mucosa / Q000166:cytology / Q000502:physiology*
D008024:Ligands; D011956:Receptors, Cell Surface