Specialised adaptors in immune cells.
Adaptors are modular proteins implicated in the orchestration of intracellular signalling pathways. Studies of adaptors specifically expressed in immune cells have provided clear examples of the importance of adaptor molecules in normal mammalian biology. Moreover, they have led to the identification of naturally occurring mutations in adaptors that can be linked to human diseases. Lastly, they have highlighted the plasticity of protein-protein interaction modules, and have shed light onto the mechanisms dictating the specificity of adaptor-mediated signals.
Veillette
André
A
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada. veillea@ircm.qc.ca
D033942:Adaptor Proteins, Vesicular Transport / Q000235:genetics / Q000276:immunology*; D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000235:genetics / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D017434:Protein Structure, Tertiary / Q000235:genetics; D021381:Protein Transport / Q000235:genetics / Q000276:immunology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein
D033942:Adaptor Proteins, Vesicular Transport; D047908:Intracellular Signaling Peptides and Proteins; D011956:Receptors, Cell Surface; C114953:SH2D1A protein, human; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein