[The influence of lectins on the aggregation of neutrophils and erythrocytes in healthy humans].
A study was made of the influence of some plant lectins on the aggregation of neutrophils and erythrocytes in healthy humans, and the state of carbohydrate determinants of glycoprotein receptors of these cells was characterized. These carbohydrate determinants, containing D-mannose, N-acetyl-D-glucosamin, and bD-galactose, provide neutrophils aggregation in healthy persons. The surface receptors of erythrocytes have remains of bD-galactose, several N-acetyl-D-glucosamin, N-acetyl-neyranimic acid, N-acetyl-D-galactosamin, L-fucose. Thus, in neutrophils and erythrocytes of healthy persons there is a definite composition of carbohydrate determinants of glycoproteins. Changes in these carbohydrate determinants are able to increase cells aggregation and, consequently, to disturb reological property of the blood, and to impair processes of microcirculation and thrombose stimulation.
Kirichuk
V F
VF
State Medical University, Saratov.
Voskoboĭ
I V
IV
D000116:Acetylgalactosamine / Q000378:metabolism; D000117:Acetylglucosamine / Q000378:metabolism; D002449:Cell Aggregation / Q000187:drug effects; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005260:Female; D005643:Fucose / Q000378:metabolism; D005690:Galactose / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D008297:Male; D008358:Mannose; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D037121:Plant Lectins / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism
D006023:Glycoproteins; D037121:Plant Lectins; D011956:Receptors, Cell Surface; D005643:Fucose; D000116:Acetylgalactosamine; D008358:Mannose; D000117:Acetylglucosamine; D005690:Galactose