title: Myoid hamartomas of the breast: report of 3 cases and review of the literature.
abstract: Hamartomas were first described by Albrecht in 1904, who defined them as tumor-like malformations in which there was abnormal blending of the normal components of an organ. The myoid hamartoma is a rare benign lesion of the breast and has an uncertain origin, possibly in the walls of the blood vessels, muscularis mammillae of the areolae, and mainly in myoepithelium. We report 3 cases of myoid hamartomas of the breast, with the clinical, radiologic, and histopathological findings, and review the literature. The 3 lesions showed normal breast ducts and lobules, entrapped by a muscular stroma and some foci of mature adipose tissue. The muscular origin of part of the stroma was confirmed by strong reactiveness with smooth-muscle actin.
authors.affiliation: Department of Pathology, Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: Osvaldo Giannotti
authors.initials: OG
authors.lastname: Filho
authors.forename: Angela Navarro
authors.initials: AN
authors.lastname: Gordan
authors.forename: Regina De Arruda
authors.initials: Rde A
authors.lastname: Mello
authors.forename: Cristovam Scapulatempo
authors.initials: CS
authors.lastname: Neto
authors.forename: Thaís
authors.initials: T
authors.lastname: Heinke
mesh_terms: D000199:Actins / Q000378:metabolism; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001706:Biopsy; D001941:Breast Diseases / Q000378:metabolism / Q000473:pathology*; D003893:Desmin / Q000378:metabolism; D005260:Female; D006222:Hamartoma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008327:Mammography; D008875:Middle Aged; D009130:Muscle, Smooth / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
chemical_list: D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D003893:Desmin; D014746:Vimentin