Identification and characterization of CD8+ suppressor T cells.
It has long been appreciated that certain subsets of T cells are capable of suppressing immune reactions. Initially, such T cells were described as CD8+ suppressor T cells (Ts) and there is a vast body of research spanning 30 years that describes the immunobiology of CD8+ Ts. However, studies on CD8+ Ts have suffered from the inability to distinguish CD8+ Ts from CD8+ T cells of other phenotypes. Here we present a brief history of CD8+ Ts, a review of recent progress distinguishing CD8+ Ts as a unique subset of CD8+ T cells, and an overview of the evolving immunological context in which CD8+ Ts function.
Zimring
James C
JC
Department of Pathology, Emory University School of Medicine, Woodruff Memorial Research Building, Room 7301, 101 Woodruff Circle, Atlanta, GA 30322, USA. jzimrin@emory.edu
Kapp
Judith A
JA
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D051379:Mice; D012799:Sialyltransferases; D013491:Suppressor Factors, Immunologic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D015703:Antigens, CD; D012799:Sialyltransferases; D013491:Suppressor Factors, Immunologic; C093493:ST6GAL1 protein, human; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase