[The role of phosphoinositide signaling in the lower eukaryotes].
The recent achievements on phosphoinositide signaling in the unicellular eukaryotes have been reviewed. Special attention is paid to mechanisms of phospholipase C (PLC) activation and its interaction with both cell surface receptors and effector cytoplasm targets. We discuss the role of protein kinase C (PKC) in intracellular signaling, and the relationship between the PI-signal pathway key enzymes with protein kinases of cAMP-PKA and MAP-kinase pathways.
Shemarova
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IV
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg. irina@lis.mail.iephb.ru
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D056890:Eukaryota / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D010716:Phosphatidylinositols / Q000378:metabolism*; D011493:Protein Kinase C / Q000502:physiology; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction; D010738:Type C Phospholipases / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism*
D010716:Phosphatidylinositols; D011956:Receptors, Cell Surface; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D010738:Type C Phospholipases