Calorimetric studies of the action of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride on the growth of microorganisms.
The water-soluble quaternary ammonium salt of chitosan was synthesized by reaction of chitosan with glycidyl trimethylammonium chloride. It was characterized by Fourier transform infrared and carbon-13 magnetic resonance spectra. Its microbiostatic effects against Staphylococcus aureus, Escherichia coli and Candid albicans were explored by microcalorimetry. The antimicrobial activity of the quaternized chitosan was stronger in alkaline condition than that in weak acidic condition.
Qin
Caiqin
C
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. qincq@sohu.com
Xiao
Qi
Q
Li
Huirong
H
Fang
Mu
M
Liu
Yi
Y
Chen
Xinyou
X
Li
Qiang
Q
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001671:Biochemistry / Q000379:methods; D002151:Calorimetry / Q000379:methods*; D002176:Candida albicans / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D048271:Chitosan / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014867:Water
D000890:Anti-Infective Agents; C495830:chitosan-N-2-hydroxypropyl trimethyl ammonium chloride; D014867:Water; D048271:Chitosan