[Characteristics of pain reaction and sensitivity in species of different genetic groups].
The development of a painful syndrome in two genetic lines of mice 57BL/6J and CBA/CaLac was investigated in experiments with the formalin test. It have been shown the influence of nociceptive stimulus on behaviour of animals, the presence of essential distinctions in painful behavioural reaction and other behavioural states, the difference in a painful threshold on electric stimulus between these both groups of animals. The nociceptive stimulus results in reduction of behaviour mobility states of animals and increases the passive behaviour states. The genetic line of mice 57BL/6J has shown higher values of intensity of painful reaction at the lower background painful sensitivity to electric stimulus, animal lines 57BL/6J were more mobile than animal lines CBA/CaLac. Such character of animal behaviour in lines C57BL/6J suggests the increased reactivity of nervous system of these animals, it may serve as a model for studying the cellular mechanisms of development of somatic pain for finding effective hypoanalgetic steps.
Sushko
B S
BS
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Budak
A V
AV
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D004558:Electric Stimulation; D005557:Formaldehyde / Q000008:administration & dosage; D005838:Genotype; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010146:Pain / Q000235:genetics*; D017288:Pain Threshold / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D013045:Species Specificity
D005557:Formaldehyde