title: Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family.
abstract: [structure: see text] Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.
authors.affiliation: Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Cichewicz
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Valeriote
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry* / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D011714:Pyrans; D011753:Pyrones; C498383:psymberin; C100127:pederin