Synthesis of omega-hydroxy ketones from omega-benzyloxy Weinreb amides by using a chemoselective nucleophilic addition/Birch reduction process.
[reaction: see text] A chemoselective nucleophilic addition/Birch reduction process applied to omega-benzyloxy Weinreb amides led to omega-hydroxy ketones in good yields.
Taillier
Catherine
C
Laboratoire de Chimie Organique, associé au CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Bellosta
Véronique
V
Meyer
Christophe
C
Cossy
Janine
J
D000577:Amides / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis*; D008274:Magnesium / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction
D000577:Amides; D007659:Ketones; D009942:Organometallic Compounds; D008274:Magnesium