title: TRAM linker: a safety-catch linker for the traceless release of acrylamides.
abstract: [reaction: see text] A novel safety-catch linker for the solid-phase synthesis of small-molecule libraries containing electrophilic reactive groups has been developed. Upon cleavage from solid support, the linker generates a Michael acceptor (an acrylamide) on each library member. Utilization of a two-resin system in the final cleavage step provides crude products in high purity, allowing direct use in biological assays following filtration and evaporation.
authors.affiliation: Departments of Chemistry and Biochemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ciolli
authors.forename: Sean
authors.initials: S
authors.lastname: Kalagher
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Belshaw
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D012117:Resins, Synthetic / Q000737:chemistry
chemical_list: D000178:Acrylamides; D012117:Resins, Synthetic