Gentamicin concentrations in diagnostic aspirates from 25 patients with hip and knee arthroplasties.
BACKGROUND
There is little information on long-term release of antibiotics from impregnated bone cement.


METHODS
We assayed joint fluids obtained for diagnostic purposes from 25 patients for the presence of gentamicin. All patients had presented with failing or painful joints up to 20 years following primary hip or knee arthroplasty, using gentamicin-impregnated cement.


RESULTS
Gentamicin was detected in the joint fluids from 9 of 15 patients with knee prostheses and 4 of 10 patients with hip prostheses. The concentrations ranged from 0.06 mg/L to 0.85 mg/L with no significant differences in concentration between the patients with hip or knee prostheses, or the type of prosthesis. We found no relationship between the gentamicin concentration and the time after primary arthroplasty.


CONCLUSIONS
Although most concentrations were below the levels required to inhibit susceptible pathogens, we conclude that gentamicin release around failing implants may lead to false negative cultures in some patients and provide selective pressure for the emergence of resistance where infection is present in others.
Fletcher
Matthew D A
MD
Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK.
Spencer
Robert F
RF
Langkamer
V George
VG
Lovering
Andrew M
AM
D000368:Aged; D000900:Anti-Bacterial Agents / Q000032:analysis*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D001843:Bone Cements; D016503:Drug Delivery Systems; D005260:Female; D005839:Gentamicins / Q000032:analysis*; D006801:Humans; D007595:Joint Prosthesis; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D013582:Synovial Fluid / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins