title: Phenolic and furan type compounds isolated from Gastrodia elata and their anti-platelet effects.
abstract: Nine phenolic (1-9) and two furan type (10, 11) compounds, were isolated from the methanolic extract of the tuber of Gastrodia elata Blume (Orchidaceae) in the course of continuing search for platelet anti-aggregating plant components. Compound 1 was identified as 4,4'-dihydroxybenzyl sulfone, a novel compound for the best of our knowledge. Compound 10, 5-hydroxymethyl-2-furancarboxaldehyde, was isolated for the first time from this plant. Compound 1 (IC50; 83 microM) was about four times more inhibitory to U46619 induced aggregation than ASA (IC50; 340 microM). Compound 9, 4,4'-dihydroxy-dibenzylether, (IC50; 5 microM, 3 microM and 33 microM, respectively) was 10-80 fold more potent than ASA (IC50; 420 microM, 53 microM and 340 microM respectively) to collagen, epinephrine and U46619 induced aggregation, although it is less active than ASA to AA induced aggregation.
authors.affiliation: Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Pyo
authors.forename: Jing Ling
authors.initials: JL
authors.lastname: Jin
authors.forename: Yean Kyoung
authors.initials: YK
authors.lastname: Koo
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Yun-Choi
mesh_terms: D000818:Animals; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031668:Gastrodia; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D035281:Plant Tubers; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats
chemical_list: D005663:Furans; D010636:Phenols; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors