title: REF-ereeing the cytoplasmic fate of mRNA via nuclear export.
abstract: The C. elegans sex-determining gene tra-2 is subject to multiple forms of regulation. A report in the June 4 issue of Molecular Cell now shows that proteins associated with the tra-2 mRNA determine its pathway of nuclear export and influence its cytoplasmic fate. These findings demonstrate an additional level of control and link nuclear export to the regulation of sexual development.
authors.affiliation: Department of Systems Biology, Harvard Medical School and Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Adrienne E
authors.initials: AE
authors.lastname: McKee
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Silver
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics*; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000235:genetics*; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D019849:Sex Determination Processes; D012733:Sex Differentiation / Q000235:genetics
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D029742:Caenorhabditis elegans Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; C428453:ref-1 protein, C elegans; C076107:tra-2 protein, C elegans