[Study on the TIL and NK of IL-2 injected via pelvic retroperitoneal space in gynecological cancer patient].
OBJECTIVE
To verify the feasibility and effect of biotherapy instituted via pelvic retroperitoneal space on gynecological cancer.


METHODS
Injecting IL-2 (and/or) 5-Fu through a tube installed in the pelvic retroperitoneal space. Counting the subpopulation of T cell and NK of lymph-nodes of pelvis after the drugs being by FCM.


RESULTS
The numbers of CD3+, CD4+, CD8+, CD25+ and NK cells in treatment group were significantly higher than those in the control group. And the numbers of these cells in the IL-2 + 5-Fu group were significantly higher than those in the 5-Fu group. The CD25+ and NK cell numbers in the IL-2 group were significantly higher than those in the 5-Fu group (P < 0.05).


CONCLUSIONS
The IL-2 injected via pelvic retroperitoneal space can promote the activity, development and infiltrating of T cell and NK cell in the tumor tissue.
Chen
Jie
J
Department of Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Cao
Ze-yi
ZY
Zhang
Ping
P
Peng
Zhi-lan
ZL
Yang
Yan-lin
YL
Bi
Jian-hong
JH
D000328:Adult; D005260:Female; D006801:Humans; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000008:administration & dosage*; D007694:Killer Cells, Natural / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000628:therapy*; D012187:Retroperitoneal Space; D016176:T-Lymphocyte Subsets / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000276:immunology / Q000628:therapy*
D007376:Interleukin-2