Review of 26 cases of classical pyoderma gangrenosum: clinical and therapeutic features.
BACKGROUND
Classical pyoderma gangrenosum (CPG) is an uncommon, idiopathic, neutrophilic skin disease, generally associated with other skin conditions and systemic diseases, and with several treatment options.


OBJECTIVE
The objective of this review was to know the clinical and therapeutic features of our cases of CPG.


METHODS
Twenty-six cases of CPG were included; 65 episodes of PG and 120 treatment courses were analysed; and the mean follow-up was 4.6 years.


RESULTS
21 cases (80%) had lesions on the lower extremities, 16 (61%) had recurrences, 22 (84%) had some disease associated, and 13 (50%) had autoimmune inflammatory conditions. Cyclosporin A (CSA) was used in 22 (84%) patients and 51 (78%) episodes, and prednisone (PDN) was used in 15 (57%) patients and 26 (40%) episodes.


CONCLUSIONS
CSA efficacy was excellent, with an early response and acceptable toxicity, although it did not seem to have any impact on the incidence of PG recurrences.
Vidal
D
D
Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. 33053dvs@comb.es
Puig
L
L
Gilaberte
M
M
Alomar
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D012008:Recurrence; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
D007166:Immunosuppressive Agents; D016572:Cyclosporine