Novel tissue and cell type-specific gene/drug delivery system using surface engineered hepatitis B virus nano-particles.
The hepatitis B virus (HBV) surface antigen (HBsAg) L particle is a hollow nano-scale particle. HBsAg L particles have many properties that make them useful for in vivo gene transfer vectors and drug delivery systems. Gene therapy so far has required the in vivo pinpoint delivery of genetic materials into the target organs and cells. Gene transfer by HBsAg L particles might be an attractive method, since their tropism is the same as that of HBV. The HBsAg L particles are able to deliver therapeutic payloads with high specificity to human hepatocytes. In addition, the specificity of L particle can be altered by displaying various cell-binding molecules on the surface. Our results indicate that the L particle is suitable for a cell- and tissue-specific gene/drug transfer vector. In this review, we discuss HBsAg L particles as a gene/drug transfer vector and its potential for the treatment of infectious diseases.
Yamada
Tadanori
T
Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka, 567-0047, Japan.
Ueda
Masakazu
M
Seno
Masaharu
M
Kondo
Akihiko
A
Tanizawa
Katsuyuki
K
Kuroda
Shun'ichi
S
D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy; D005822:Genetic Vectors; D006509:Hepatitis B / Q000235:genetics / Q000628:therapy; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics / Q000628:therapy; D006801:Humans; D036103:Nanotechnology; D010316:Particle Size
D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines