Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome.
The dynamics of free radical processes during the acute stage of ischemic stroke and their relationship with the clinical status of patients were studied. An enhanced extracellular generation of reactive oxygen species (ROS) by peripheral phagocytes was observed in severe stroke patients during the whole acute stage. This generation correlated positively with the size of infarct, the severity of neurological deficit and handicap and correlated negatively with the improvement of the neurological status of patients. An increase in the activity of two enzymes from the antioxidant defense mechanism, catalase and glutathione peroxidase, was registered during the whole acute phase of stroke, regardless of its severity. The concentration of lipid peroxidation products increased over time. Blood concentration of thiobarbituric acid-reactive material (TBARM) correlated positively with the size of infarct, the severity of neurological deficit and handicap. In conclusion, extracellular ROS generation by phagocytes and blood TBARM concentration could be used as indicators for stroke outcome.
Alexandrova
Margarita
M
Department of Biophysics, Medical University, Pleven, Bulgaria. margalexandrova@hotmail.com
Bochev
Petyo
P
Markova
Vanya
V
Bechev
Blagovest
B
Popova
Marina
M
Danovska
Maya
M
Simeonova
Virginia
V
D000208:Acute Disease; D000368:Aged; D000704:Analysis of Variance; D000975:Antioxidants; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D010586:Phagocytes / Q000187:drug effects / Q000378:metabolism; D020521:Stroke / Q000378:metabolism*; D013482:Superoxide Dismutase; D017392:Thiobarbituric Acid Reactive Substances; D013997:Time Factors; D015054:Zymosan / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances; D015054:Zymosan; D013482:Superoxide Dismutase