title: A novel promoter polymorphism (-71C>T) in KRTHB6 gene in Indian population.
abstract: We have screened the basal promoter region, of KRTHB6 gene involving CAAT and TATA boxes in randomly selected 125 individuals of Indian origin by PCR-SSCP and DNA sequencing. We observed a novel promoter polymorphism (-71C>T) which could be differentiated by using LweI restriction enzyme. The frequency of -71 C allele, allele A (Accession no AY203963), was observed to be higher ( 0.712) in comparison to -71 T allele, allele B (0.288) (Accession no. AY037552).
authors.affiliation: National Centre of Applied Human Genetics, Human Genetics Section, School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India.
authors.forename: Narendra K
authors.initials: NK
authors.lastname: Bairwa
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Malhotra
authors.forename: Anjana
authors.initials: A
authors.lastname: Saha
authors.forename: R
authors.initials: R
authors.lastname: Bamezai
mesh_terms: D001483:Base Sequence; D006801:Humans; D007194:India; D007633:Keratins / Q000235:genetics*; D008969:Molecular Sequence Data; D018807:Polymorphism, Single-Stranded Conformational; D011401:Promoter Regions, Genetic; D016385:TATA Box
chemical_list: D007633:Keratins