title: Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulation.
abstract: A 73-year-old man with Parkinson's disease underwent thalamic stimulation for disabling tremor with excellent results only when stimulation on. Post-mortem neuropathology (7 years postoperatively) revealed 60% cell loss within 0.5 mm of the electrode tip. Tremor improvement was attributable to chronic stimulation, not microthalamotomy.
authors.affiliation: Department of Pharmacology, University of Sydney, NSW, Australia. henderson@med.usyd.edu.au
authors.forename: Jasmine
authors.initials: J
authors.lastname: Henderson
authors.forename: Michael
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Dudley
authors.initials: D
authors.lastname: O'Sullivan
authors.forename: Malcolm
authors.initials: M
authors.lastname: Pell
authors.forename: Victor
authors.initials: V
authors.lastname: Fung
authors.forename: Alim Louis
authors.initials: AL
authors.lastname: Benabid
authors.forename: Glenda
authors.initials: G
authors.lastname: Halliday
mesh_terms: D004558:Electric Stimulation / Q000295:instrumentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D011846:Radio Waves; D020651:Ventral Thalamic Nuclei / Q000473:pathology*