Survey of ferroxidase expression and siderophore production in clinical isolates of Pseudomonas aeruginosa.
Ferroxidase (encoded by the mco gene), a component of a ferrous iron uptake pathway in Pseudomonas aeruginosa, was detected in all of the 35 respiratory clinical isolates surveyed; in contrast, considerable variation in siderophore expression was observed. The ubiquitous expression of this periplasmic ferroxidase suggests that it plays a key role in iron uptake in this opportunistic pathogen.
Huston
Wilhelmina M
WM
Centre for Metals in Biology, Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, 4072, Queensland, Australia.
Potter
Adam J
AJ
Jennings
Michael P
MP
Rello
Jordi
J
Hauser
Alan R
AR
McEwan
Alastair G
AG
D002570:Ceruloplasmin / Q000032:analysis*; D006801:Humans; D007501:Iron / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D017262:Siderophores / Q000096:biosynthesis*
D017262:Siderophores; D007501:Iron; D010088:Oxidoreductases; C024748:copper oxidase; D002570:Ceruloplasmin