title: HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma.
abstract: The current study focuses the analysis on the possible relationship between HLA allele frequency and clinical outcome of melanoma in a population of 382 Italian patients, as compared with 203 ethnically matched controls. In a 3-year follow-up study, results showed significant differences between groups of patients selected according to clinical stage, histology, and progression of the disease. A*01 seems to be correlated with a less aggressive variant of the disease, whereas DRB1*01-DQB1*0501 seems to be associated with metastatic progression of melanoma. Moreover, a negative association with B*13, B*44, as well as with DRB1*04-DQB1*0302 was found. A multivariate logistic regression model showed HLA-DRB1*04 to behave as an independent favorable prognostic marker of melanoma in our population (OR = 2.34, CI = 1.15-4.74).
authors.affiliation: Oncologia Sperimentale C-Immunologia, Istituto Nazionale Tumori, Napoli, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Luongo
authors.forename: G
authors.initials: G
authors.lastname: Pirozzi
authors.forename: C
authors.initials: C
authors.lastname: Caracò
authors.forename: S
authors.initials: S
authors.lastname: Errico
authors.forename: F
authors.initials: F
authors.lastname: de Angelis
authors.forename: E
authors.initials: E
authors.lastname: Celentano
authors.forename: F
authors.initials: F
authors.lastname: Paino
authors.forename: M G
authors.initials: MG
authors.lastname: Chiofalo
authors.forename: M
authors.initials: M
authors.lastname: Luongo
authors.forename: N
authors.initials: N
authors.lastname: Mozzillo
authors.forename: M L
authors.initials: ML
authors.lastname: Lombardi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D007558:Italy; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000276:immunology* / Q000556:secondary; D008875:Middle Aged; D011379:Prognosis; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains