Pulsatile luteinizing hormone disruption in depression.
Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they reached different conclusions: Meller et al. [Am. J. Psych. 154 (1997) 1454] found disruption of normal LH pulsatility in depressed women, whereas Young et al. [Arch. Gen. Psych. 57 (2000) 1157] did not. To resolve this discrepancy, the current study applies a single, well-established statistical method, spectral analysis, to the two data sets and concludes that both depressed populations display significantly altered LH pulsatile release.
Grambsch
Patricia
P
Division of Biostatistics, School of Public Health MMC303, University of Minnesota, 412 Delaware Street SE, Mayo A-460, Minneapolis, MN 55455, USA. pat@biostat.umn.edu
Young
Elizabeth A
EA
Meller
William H
WH
D000328:Adult; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D005498:Follicular Phase / Q000097:blood*; D005583:Fourier Analysis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008183:Luteal Phase / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D010507:Periodicity
D007986:Luteinizing Hormone