title: Tenascin and fibronectin expression in odontogenic cysts.
abstract: BACKGROUND
  Odontogenic cysts (OCs) present distinct evolution and clinical behavior. This study was performed in order to investigate if some components of the extracellular matrix (ECM) may drive these differences.
  
  
  METHODS
  Thirty OCs were selected: 10 radicular cysts (RCs), 10 dentigerous cysts (DCs), 10 non-syndrome odontogenic keratocysts (OKCs) and they were immunohistochemically analyzed to verify the expression pattern of tenascin and fibronectin.
  
  
  RESULTS
  Tenascin immunostaining was mainly intense as a thick band deep to the epithelial-mesenchymal interface in both RCs and OKCs. The intense tenascin immunoexpression observed in the RCs was usually associated with inflammation. An intense fibronectin reactivity was observed in the basement membrane region and at the cystic wall of OKCs.
  
  
  CONCLUSIONS
  Our results demonstrate differences between the expression of ECM proteins in the OCs studied. The higher tenascin and fibronectin expression in the capsule of OKCs suggests marked instability in the cystic structure and may contribute to its aggressive behavior.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Norte, Natal-RN, Brazil.
authors.forename: Marcílio Dias Chaves
authors.initials: MD
authors.lastname: de Oliveira
authors.forename: João Luiz
authors.initials: JL
authors.lastname: de Miranda
authors.forename: Rivadávio Fernandes Batista
authors.initials: RF
authors.lastname: de Amorim
authors.forename: Lélia Batista
authors.initials: LB
authors.lastname: de Souza
authors.forename: Roseana
authors.initials: R
authors.lastname: de Almeida Freitas
mesh_terms: D005353:Fibronectins / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D009807:Odontogenic Cysts / Q000378:metabolism*; D019063:Tenascin / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D005353:Fibronectins; D019063:Tenascin