title: [The relationship of angiotensin I-converting enzyme gene polymorphism with diabetic retinopathy and diabetes myocardial infarction].
abstract: OBJECTIVE
  To investigate the relationship of angiotensin I-converting enzyme (ACE) gene polymorphism to diabetic retinopathy and diabetes myocardial infarction.
  
  
  METHODS
  ACE insertion/deletion(I/D) polymorphism was determined by PCR.
  
  
  RESULTS
  No evidence showed that ACE gene was associated with diabetic retinopathy. By comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).
  
  
  CONCLUSIONS
  Allele D(RR=1.50) and genotype DD(RR=1.33) seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.
authors.affiliation: Department of Biotechnology, North China Coal Medical College, Tangshan, Hebei, 063000 PR China. Ts-wss@163.com
authors.forename: Shou-shan
authors.initials: SS
authors.lastname: Wu
authors.forename: Qing-mei
authors.initials: QM
authors.lastname: Guo
authors.forename: Ge-ling
authors.initials: GL
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.forename: Chen-fu
authors.initials: CF
authors.lastname: Zhao
authors.forename: Shu-cheng
authors.initials: SC
authors.lastname: Ning
authors.forename: Li-na
authors.initials: LN
authors.lastname: Zhao
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Hong-li
authors.initials: HL
authors.lastname: Yi
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A