title: Frontotemporal dementia linked to chromosome 3.
abstract: A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
authors.affiliation: Department of Neurology, Addenbrooke's Hospital, Cambridge, UK. jmb75@medschl.cam.ac.uk
authors.forename: Jerry
authors.initials: J
authors.lastname: Brown
authors.forename: Susanne
authors.initials: S
authors.lastname: Gydesen
authors.forename: Peter
authors.initials: P
authors.lastname: Johannsen
authors.forename: Anders
authors.initials: A
authors.lastname: Gade
authors.forename: Gaia
authors.initials: G
authors.lastname: Skibinski
authors.forename: Lisa
authors.initials: L
authors.lastname: Chakrabarti
authors.forename: Arne
authors.initials: A
authors.lastname: Brun
authors.forename: Maria
authors.initials: M
authors.lastname: Spillantini
authors.forename: Despina
authors.initials: D
authors.lastname: Yancopoulou
authors.forename: Tove
authors.initials: T
authors.lastname: Thusgaard
authors.forename: Asger
authors.initials: A
authors.lastname: Sorensen
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fisher
authors.forename: John
authors.initials: J
authors.lastname: Collinge
mesh_terms: D001921:Brain / Q000473:pathology; D002893:Chromosomes, Human, Pair 3; D003704:Dementia / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D003718:Denmark; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010641:Phenotype