title: Quinoxaline N,N'-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure-activity relationships.
abstract: Quinoxaline derivatives presented good inhibitor activity of growth of Trypanosoma cruzi in in vitro assays. The 50% inhibitory doses were of the same order of that of Nifurtimox. Derivative 13, a quinoxaline N,N'-dioxide derivative, and the reduced derivatives 19 and 20 were the most cytotoxic compounds against the protozoan. Structural requirements for optimal activity were studied by computational methods. From statistical analysis we could establish a multiple correlation between activity and lipophilic properties and LUMO energy.
authors.affiliation: Departamento de Química Orgánica, Facultad de Química, Facultad de Ciencias, Universidad de la República, Iguá 4225, 11400 Montevideo, Uruguay.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Aguirre
authors.forename: Hugo
authors.initials: H
authors.lastname: Cerecetto
authors.forename: Rossanna
authors.initials: R
authors.lastname: Di Maio
authors.forename: Mercedes
authors.initials: M
authors.lastname: González
authors.forename: María Elena Montoya
authors.initials: ME
authors.lastname: Alfaro
authors.forename: Andrés
authors.initials: A
authors.lastname: Jaso
authors.forename: Belén
authors.initials: B
authors.lastname: Zarranz
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Ortega
authors.forename: Ignacio
authors.initials: I
authors.lastname: Aldana
authors.forename: Antonio
authors.initials: A
authors.lastname: Monge-Vega
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003497:Cyclic N-Oxides / Q000138:chemical synthesis / Q000494:pharmacology; D003627:Data Interpretation, Statistical; D009547:Nifurtimox / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D003497:Cyclic N-Oxides; D011810:Quinoxalines; D014344:Trypanocidal Agents; D009547:Nifurtimox