Antibody response can be conditioned using electroacupuncture as conditioned stimulus.
To establish a new model of conditioned enhancement of antibody production, electroacupuncture was served as the conditioned stimulus (CS) and an injection of a protein antigen ovalbumin as the unconditioned stimulus (UCS). After a CS/UCS pairing was made, re-exposure of animals to the CS alone resulted in significant conditioned enhancement of anti-ovalbumin antibody production. Even in deep sleep induced by anesthesia, the animals can associate a single CS with UCS and an antibody response can be elicited upon subsequent re-exposure to CS in the absence of exogenous antigen. No effect of electroacupuncture on anti-ovalbumin antibody production was found.
Huang
Jing-Xin
JX
Key Laboratory of Mental Health, Chinese Academy of Sciences, Beijing 100101, PR China.
Lin
Wen-Juan
WJ
Chen
Jihuan
J
D000758:Anesthesia; D000818:Animals; D000906:Antibodies / Q000378:metabolism*; D003213:Conditioning, Psychological; D015671:Electroacupuncture; D007114:Immunization; D008297:Male; D015213:Neuroimmunomodulation / Q000502:physiology*; D010047:Ovalbumin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep
D000906:Antibodies; D010047:Ovalbumin