[Expression and its significance of b-FGF in human benign prostatic hyperplasia and prostatic carcinoma tissues].
OBJECTIVE
To investigate the clinical significance of basic fibroblast growth factor (b-FGF) in human benign prostatic hyperplasia (BPH) and prostatic carcinoma (Pca).


METHODS
b-FGF expressions were examined by RNA dot blot hybridization and immunohistochemical staining in prostate tissues from 40 normal cases (NP), 38 BPH and 36 Pca.


RESULTS
The expressions of b-FGF in BPH and Pca tissues were significantly higher than those in normal prostate tissues (P < 0.01). There was no significant correlation between the increased expression of b-FGF and the graduation of BPH, pathologic grading as well as clinical stages of Pca.


CONCLUSIONS
b-FGF may be secreted from BPH and Pca tissues themselves, which is closely involved in the genesis and development of BPH and Pca.
Wang
Fu-li
FL
Department of Urology, Fourth Military Medical University, Xi'an 710032, China. wangfuli98@163.com
Wang
He
H
Qin
Wei-jun
WJ
Wu
Guo-jun
GJ
Zhang
Geng
G
Li
Kai-nan
KN
D000368:Aged; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2