Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells.
Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.
Karube
Kennosuke
K
Department of Pathology, School of Medicine, Fukuoka University, Fukuoka, Japan. xs255@cis.fukuoka-u.ac.jp
Ohshima
Koichi
K
Tsuchiya
Takeshi
T
Yamaguchi
Takahiro
T
Kawano
Riko
R
Suzumiya
Junji
J
Utsunomiya
Atae
A
Harada
Mine
M
Kikuchi
Masahiro
M
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D015704:CD4 Antigens; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000235:genetics; D005260:Female; D051858:Forkhead Transcription Factors; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers; D015704:CD4 Antigens; D004268:DNA-Binding Proteins; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D015375:Receptors, Interleukin-2