title: [Immunological up-regulation of cyclophosphamide-treated mice by turtle blood extract].
abstract: OBJECTIVE
  To explore the effect of turtle blood extract on murine immune system.
  
  
  METHODS
  We compared the ratio of CD4(+) helper T cells and CD8(+) T cells, NK cell activity, lymphocyte proliferation stimulated by mitogen and capability of cytokine secretion of cyclosphophamide-treated mice with or without treatment of turtle blood extract.
  
  
  RESULTS
  Turtle blood extract-treated mice displayed increased CD4(+) helper T cell population, stronger cytotoxicity of NK cells and enhanced of ConA-induced lymphocyte proliferation. In addition, the capacity of IFN-gamma secretion was dramatically up-regulated in turtle blood extract-treated mice group.
  
  
  CONCLUSIONS
  Turtle blood extract can upregulate the immune function of cyclosphophamide-treated mouse.
authors.affiliation: Shanghai Institute of Immunology, Shanghai Second Medical University, Shanghai 200025, China. ywang@sibs.ac.cn
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui-zhen
authors.initials: HZ
authors.lastname: Zhang
authors.forename: Shu-jun
authors.initials: SJ
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tian-wei
authors.initials: TW
authors.lastname: Shen
authors.forename: Guang-jie
authors.initials: GJ
authors.lastname: Chen
authors.forename: Hai-liang
authors.initials: HL
authors.lastname: Ge
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014426:Turtles / Q000097:blood*; D015854:Up-Regulation
chemical_list: D000276:Adjuvants, Immunologic; D003520:Cyclophosphamide