[Pharmacokinetic evaluation of the tablet dosage forms of gidazepam prepared by various technologies].
The pharmacokinetics of gidazepam administered in tablets prepared using different technologies was studied in rabbits. The optimum properties (high relative bioaccessibility and low degree of dealkylation of the parent substance) were observed for the tablets fabricated using a solid disperse system.
Kolyvanov
G B
GB
Laboratory of Pharmacokinetics and Laboratory of Clinical Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
D000818:Animals; D001569:Benzodiazepines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D004337:Drug Carriers; D008297:Male; D011817:Rabbits; D013607:Tablets; D014149:Tranquilizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*
D004337:Drug Carriers; D013607:Tablets; D014149:Tranquilizing Agents; D001569:Benzodiazepines; C077010:gidazepam