[Phadiatop in the diagnosis of respiratory allergy in children: Allergy Project--PROAL].
OBJECTIVE
To evaluate the positivity of Phadiatop in children from several Brazilian pediatric allergology centers and to compare its results with the presence of serum specific IgE to inhalant and food allergens.


METHODS
Phadiatop and serum specific IgE levels (RAST) to inhalant and food allergens (UniCAP - Pharmacia) were measured in 457 children from several pediatric allergy centers and in a non-allergic control group (n = 62), distributed across five age groups.


RESULTS
Phadiatop was positive in 305 atopic children (67.6%) and in 25.8% of controls (p < 0.001). Among atopic children the distribution of positive test varied according to age: 7.9% (24/305) among under 2 year-olds, 15.4% (47/305) in 2 to 3 year-olds, 22.0% (67/305) in 3 to 4 year-olds, 19.3% (59/305) in 4 to 5 year-olds and 35.4% (108/305) in 5 to 12 year-olds. No concordance between food allergens and Phadiatop was observed. Analysis of the relationship between positive inhaled allergen RASTs and positive Phadiatop showed best indices with house dust mites (D. pteronyssinus, D. farinae and Blomia tropicalis).


CONCLUSIONS
Phadiatop is a useful tool for diagnosing domestic mite allergy.
Naspitz
Charles K
CK
Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Solé
Dirceu
D
Aguiar
Maria Cecília
MC
Chavarria
Maria Letícia
ML
Rosário Filho
Nelson
N
Zuliani
Antônio
A
Toledo
Eliana C
EC
Barreto
Bruno A P
BA
Souza
Leda S F
LS
D017677:Age Distribution; D000485:Allergens / Q000276:immunology; D000818:Animals; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003710:Demography; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D008297:Male; D008403:Mass Screening; D011852:Radioallergosorbent Test / Q000379:methods*; D012130:Respiratory Hypersensitivity / Q000175:diagnosis* / Q000276:immunology
D000485:Allergens; D007073:Immunoglobulin E