Genomic portraits of the nervous system in health and disease.
As the human genome project moves toward its goal of sequencing the entire human genome, gene expression profiling by DNA microarray technology is being employed to rapidly screen genes for biological information. In this review, we will introduce DNA microarray technology, outline the basic experimental paradigms and data analysis methods, and then show with some examples how gene expression profiling can be applied to the study of the central nervous system in health and disease.
D'Agata
Velia
V
Institute of Neurological Sciences, Italian National Research Council, Catania, Italy.
Cavallaro
Sebastiano
S
D000465:Algorithms; D016000:Cluster Analysis; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics; D009420:Nervous System / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D012016:Reference Values
D009419:Nerve Tissue Proteins