Spinal cord injury: reversing the incorrect cortical maps by inductive lability procedure.
Within the brain-stem and on the cerebral cortex there are locomotor control centers arranged in a ladder-form control system. These centers are somatotopic, self-organizing neural network maps capable of simultaneously learning and task execution. In spinal cord injury (SCI) these self-organized maps get erroneously re-organized and maladaptively stabilized. The extent and quality of sensory-motor recovery, if any appears, is affected by and compromised due to incorrect mapping processes. The treatment method based on inductive lability procedure (Krishnan, 2003a, 2003b, 2003c) uses botulinum toxin for the purpose. It recreates competition among synapses in a locomotor training-based corrective re-self-organization of the maps in various steps of the ladder.
Krishnan
R V
RV
Department of Anatomy, Dr. A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India. krish_venk@yahoo.com
D000818:Animals; D018726:Anti-Dyskinesia Agents / Q000494:pharmacology; D001905:Botulinum Toxins / Q000494:pharmacology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D006801:Humans; D008124:Locomotion / Q000502:physiology*; D009415:Nerve Net / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D020127:Recovery of Function / Q000187:drug effects / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000503:physiopathology*
D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins