[Pathophysiological significance and clinical utility of circulating osteoprotegerin].
Osteoprotegerin (OPG) belongs to the tumor necrosis factor receptor superfamily and acts as a decoy receptor for the receptor activator of NF-kappaB ligand (RANKL), preventing its binding to RANK. Since 1997, the RANKL/RANK/OPG system has been intensively investigated in the fields of bone, immune and cardiovascular system pathophysiology. Specific anti-OPG antibodies have been developed, allowing for the measurement of OPG and, more recently, of soluble RANKL in both physiological and pathological conditions, often yielding unexpected results. When considering circulating OPG measurements, it should be borne in mind that this receptor is ubiquitously expressed, and that circulating levels do reflect the production by a number of tissues. Moreover, strikingly different values of circulating OPG have been reported. The aim of this paper is to summarize the available data on circulating OPG levels in a number of conditions; the pathophysiological significance and potential clinical utility will be emphasized.
Dovio
Andrea
A
Clinica Medica Generale, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Azienda Ospedaliera San Luigi di Orbassano, TO.
Data
Valeria
V
Angeli
Alberto
A
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood; D015415:Biomarkers; D001851:Bone Diseases, Metabolic / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary; D001842:Bone and Bones / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood; D002352:Carrier Proteins / Q000097:blood / Q000502:physiology; D005260:Female; D006023:Glycoproteins / Q000097:blood* / Q000502:physiology; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood / Q000502:physiology; D008875:Middle Aged; D008954:Models, Biological; D016328:NF-kappa B / Q000502:physiology; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear / Q000097:blood* / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor; D012016:Reference Values; D015203:Reproducibility of Results
D015415:Biomarkers; D002352:Carrier Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D016328:NF-kappa B; D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human