[The correlation between neck lymphy node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas].
OBJECTIVE
To explore the correlation between neck lymph node metastasis and matrix metalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas(OSCC).


METHODS
Immunohistochemistry LsAB technique was used to observe the expression of MMP-2 at the invasive tumor front and center of OSCC, and the correlation between the expression of MMP-2 in OSCC and neck lymph node metastasis were respectively analyzed by statistics.


RESULTS
The results demonstrated that MMP-2 existed in all 71 cases, which the expression of MMP-2 at the OSCC front was more significant than that of MMP-2 at the OSCC center (P < 0.01), and related to neck lymph node metastasis (P < 0.05).


CONCLUSIONS
The expression of MMP-2 at the OSCC front could be considered as an index of judging the present of neck lymph node metastasis of OSCC.
Liu
Lai-kui
LK
Dept. of Oral Pathology, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Li
Yi-ning
YN
Jiang
Hong-bing
HB
He
Zhi-xiu
ZX
Yi
Xin-zhu
XZ
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000556:secondary*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000473:pathology*; D009361:Neoplasm Invasiveness
D020778:Matrix Metalloproteinase 2