title: [Study on therapeutic window of opportunity for Panax notoginseng saponins following focal cerebral ischemia/reperfusion injury in rats].
abstract: OBJECTIVE
  To study the therapeutic window of opportunity for Panax notoginseng saponins (Pns) following focal cerebral ischemia/reperfusion injury in rats.
  
  
  METHODS
  Focal cerebral ischemia (2 h)/reperfusion (24 h) model in male rats was induced by transient occlusion and middle cerebral artery (MCA) for 2 h and reperfusion for 24 h. Drugs were administered at 3 h, 4 h, 5 h and 6 h after the onset of ischemia respectively and neurological deficit score, infarct size and brain edema were examined.
  
  
  RESULTS
  The administration of Pns at 3-4 h after onset of ischemia significantly reduced neurological deficit score, infarct size and brain edema. When administrating Pns at 5 h after onset of ischemia, the neuroprotection decreased. When administrating Pns at 6 h after onset of ischemia, there are not significant protective effects.
  
  
  CONCLUSIONS
  The therapeutic window of opportunity for Pns following focal cerebral ischemia/reperfusion injury in rats is not more than 5 h after the onset of ischemia.
authors.affiliation: Gannan Medical College, Ganzhou 341000.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Zunping
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jianxin
authors.initials: J
authors.lastname: Liu
authors.forename: Heyang
authors.initials: H
authors.lastname: Ye
authors.forename: Jin
authors.initials: J
authors.lastname: Zeng
authors.forename: Xianhua
authors.initials: X
authors.lastname: Huang
authors.forename: Fei
authors.initials: F
authors.lastname: Lai
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology*; D002544:Cerebral Infarction / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D036145:Ginsenosides / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D005894:Panax / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000473:pathology*; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides