[Fractal analysis of MCA blood flow velocity fluctuations in migraine--preliminary report].
Many reports confirm the existence of long-range correlations between fluctuations of various physiological signals in healthy subjects and demonstrate disappearance of these correlations in pathological conditions. Blood flow velocity in intracranial vessels is changeable over time and depends on complex physiological regulatory mechanisms. The character of blood flow velocity fluctuations may indicate the presence of vascular disorders associated with various diseases. The aim of our study was to establish whether fluctuations in MCA blood flow velocity are fractal in physiological conditions and if so, whether this feature is lost in migraine, as the role of vasomotoric disturbances has been already evidenced in pathophysiology of this disease. The axial flow velocity changes averaged over a cardiac beat interval were monitored continuously via two channels through the temporal windows using a DWL Multi-DopT TCD device with 2-MHz probes. The examinations were performed in supine rest in two-hour periods in two groups: of 7 patients with clinically confirmed migraine with aura during headache-free intervals (15 recordings), and in the control group of 4 young, healthy volunteers (10 recordings). The results in the form of time series were analysed using the methods of fractal statistics. Multifractality in the recordings in physiological conditions was clearly confirmed, as well as its absence in the averaged recordings in the group of migraneurs. The findings justify a supposition that the breakdown of multifractal properties of MCA blood flow time series in migraine may result from the vasomotor disturbances present even during headache-free intervals. However, possible usefulness of this method in the diagnostics of migraine requires further investigation.
Glaubic-Latka
Marta
M
Oddziału Neurologii B Wojewódzkiego Zespołu Neuropsychiatrycznego w Opolu. mlatka@wcm.opole.pl
Latka
MirosLaw
M
Latka
Dariusz
D
Bury
Wiesław
W
Pierzchała
Krystyna
K
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D002648:Child; D005260:Female; D017709:Fractals; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000503:physiopathology*; D008881:Migraine Disorders / Q000503:physiopathology*