Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients.
CCR4, a member of the CC chemokine receptor family, is believed to play an important role in the pathogenesis of atopic dermatitis. To examine whether CCR4 single nucleotide polymorphism (SNP) is associated with susceptibility to atopic dermatitis, we investigated the allele and genotype frequencies of C1014T SNP of CCR4 in 198 Japanese patients with atopic dermatitis and controls by a PCR-restriction fragment length polymorphism method. There was no significant difference in allele or genotype frequencies between patients with atopic dermatitis and controls. Serum IgE levels and peripheral blood eosinophil counts were not significantly different among genotypes. There was also no significant difference in allele or genotype frequencies between the patient subgroup with and without asthma, with mild or moderate disease, with and without family history of atopic dermatitis, or with and without family history of atopic disorders. C1014T SNP of CCR4 does not appear to be associated with susceptibility to atopic dermatitis in Japanese patients.
Tsunemi
Yuichiro
Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan. ytsun-tky@umin.ac.jp
Sekiya
Takashi
T
Saeki
Hidehisa
H
Hirai
Koichi
K
Ohta
Ken
K
Nakamura
Koichiro
K
Kakinuma
Takashi
T
Fujita
Hideki
H
Kagami
Shinji
S
Asano
Noriko
N
Tanida
Yuka
Y
Wakugawa
Motoshi
M
Torii
Hideshi
H
Tamaki
Kunihiko
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D003876:Dermatitis, Atopic / Q000208:ethnology / Q000235:genetics*; D004804:Eosinophils / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007564:Japan; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D054398:Receptors, CCR4; D019707:Receptors, Chemokine / Q000235:genetics*
C515354:CCR4 protein, human; D054398:Receptors, CCR4; D019707:Receptors, Chemokine; D007073:Immunoglobulin E