title: Indocyanine green dye-enhanced transpupillary thermotherapy of classic subfoveal choroidal neovascularization.
abstract: OBJECTIVE
  To evaluate the efficacy of indocyanine green dye-enhanced transpupillary thermotherapy for the treatment of classic subfoveal choroidal neovascular membrane (CNVM) with differing etiologies.
  
  
  METHODS
  Nine eyes of 9 patients with classic subfoveal CNVM with different etiologies that was treated with indocyanine green dye-enhanced transpupillary thermotherapy were prospectively studied. All patients underwent pretreatment fluorescein angiography. Three minutes after dye injection (25 mg of indocyanine green), transpupillary thermotherapy was delivered using a modified diode laser at 810 nm, with a variable spot size of 0.8 to 2 mm depending on the size of the CNVM. A power range between 100 and 800 mW was used and treatment was initiated in one spot for 60 seconds; the end point was a barely detectable light gray appearance of the lesion. The outcome measures were assessed by Snellen visual acuity chart and obliteration of the CNVM by fluorescein angiography. Mean follow-up was 16 months.
  
  
  RESULTS
  Obliteration of the CNVM was seen in all patients during the last visit. Visual acuity improved in one eye and remained stable (+/-2 line change on Snellen chart) in three eyes. Three eyes revealed a moderate visual loss of 3 to 4 lines and two eyes had a severe decline (> 5 lines) in vision. None of the eyes exhibited recurrence of the CNVM during follow-up.
  
  
  CONCLUSIONS
  Indocyanine green dye-enhanced transpupillary thermotherapy was highly effective in closing classic CNVM in all cases without any recurrence. Visual acuity was either stabilized or improved in 4 of 9 eyes (44.5%).
authors.affiliation: Shri Bihagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Vision Research Foundiation, 18 College Road, Chennai-600 006, India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Sharma
authors.forename: Nitant
authors.initials: N
authors.lastname: Shah
authors.forename: Lingam
authors.initials: L
authors.lastname: Gopal
authors.forename: Mahesh P
authors.initials: MP
authors.lastname: Shanmugam
authors.forename: Pramod
authors.initials: P
authors.lastname: Bhende
authors.forename: Muna
authors.initials: M
authors.lastname: Bhende
authors.forename: Nitin S
authors.initials: NS
authors.lastname: Shetty
authors.forename: B
authors.initials: B
authors.lastname: Sukumar
mesh_terms: D000328:Adult; D000368:Aged; D002829:Choroid / Q000098:blood supply; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000628:therapy*; D004396:Coloring Agents; D005451:Fluorescein Angiography; D005584:Fovea Centralis; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007208:Indocyanine Green; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D011680:Pupil; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green