A case of Epstein-Barr Virus (EBV)-associated thymic carcinoid and investigation of existence of EBV-infected cells in thymus and thymic tumors.
We describe the first case of Epstein-Barr virus (EBV)-associated thymic carcinoid tumor found by in situ hybridization (ISH) on paraffin-embedded sections. ISH revealed that both tumor cells and infiltrated lymphocytes were EBV positive, while a few EBV-infected lymphocytes were detected in 2 of 11 thymuses and 1 of 11 thymomas.
Takeuchi
Hiroaki
H
Department of Clinical Laboratory Medicine, Faculty of Medicine, Kochi University School of Medicine, Oko-cho, Nankoku, Kochi 783-8505, Japan. h.take@med.kochi-u.ac.jp
Fujita
Hiroshi
H
Iwasaki
Fumio
F
Takeuchi
Takako
T
Imadome
Ken-Ichi
K
Okumiya
Toshika
T
Matsui
Tomohiro
T
Takahashi
Mutsuo
M
D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D016612:Paraffin Embedding; D012367:RNA, Viral / Q000235:genetics; D013950:Thymus Gland / Q000821:virology*; D013953:Thymus Neoplasms / Q000473:pathology / Q000821:virology*
C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral