[Role of neurotrophin and neuropeptides in bronchial asthma].
Asthma represents a chronic inflammatory process of the airways. The neurothrophin (NGF) and neuropeptides such as substance P (SP), neurokinin A (NKA), and calcitonin gene-related peptide (CGRP) play important role in stimulation of airways inflammation in asthmatics. NGF stimulates the differentiation and the migration of mast cells to bronchi epithelium. Furthermore, NGF stimulates mast cell degranulation and mediator upregulation and release. It also influences activity of basophils, eosinophils, neurophils, macrophages and T-cells. In addition, its important role in releasing of hyperresponsiveness has been proved. Neuropeptides such as CGRP and SP stimulate migration and degranulation of eosinophils and influence on airway responsiveness in asthmatics. This review article discusses the neuropeptides and NGF actions and mechanisms in the pathogenesis of asthma.
Pałgan
Krzysztof
K
Dziedziczko
Andrzej
A
D001249:Asthma / Q000378:metabolism* / Q000503:physiopathology; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D006801:Humans; D020932:Nerve Growth Factor / Q000378:metabolism*; D015288:Neurokinin A / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism
D009479:Neuropeptides; D013373:Substance P; D015288:Neurokinin A; D020932:Nerve Growth Factor; D015740:Calcitonin Gene-Related Peptide