Heteronuclear selective refocusing 2D NMR experiments for the spectral analysis of enantiomers in chiral oriented solvents.
We report the use of carbon-proton heteronuclear selective refocusing 2D NMR experiments dedicated to the spectral analysis of enantiomers dissolved in weakly ordering chiral liquid crystalline solvents. The method permits the extraction of carbon-proton residual dipolar couplings for each enantiomer from a complex or unresolved proton-coupled 13C spectral patterns. Illustrative examples are analysed and discussed. It is shown that an accurate determination of enantiomeric excess is possible.
Farjon
Jonathan
J
Laboratoire de Chimie Structurale Organique, UMR CNRS 8074, Université Paris-Sud, ICMMO, Bât. 410, 91405 Orsay Cedex, France.
Baltaze
Jean-Pierre
JP
Lesot
Philippe
P
Merlet
Denis
D
Courtieu
Jacques
J
D000465:Algorithms; D003198:Computer Simulation; D007536:Isomerism; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D011407:Propane / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry*; D012996:Solutions; D012997:Solvents / Q000032:analysis / Q000737:chemistry*; D013237:Stereoisomerism
D012996:Solutions; D012997:Solvents; C010440:dibromopropane; D011407:Propane