Electrophilic substitution of dibromoparacyclophane: a route to novel paracyclophane phosphine ligands.
[reaction: see text] The regioselective functionalization of 4,12-dibromoparacyclophane via electrophilic aromatic substitution is reported for the first time. The functionalization of the paracyclophane backbone allows the development of a new family of paracyclophane-based phosphines (named ParaPhos) that opens the possibility of improved catalyst development and tuning while retaining all the catalysis potential of the PhanePhos family of ligands.
Dominguez
Beatriz
B
Johnson Matthey Catalysis and Chiral Technologies, Unit 28, Cambridge Science Park, Milton Road, Cambridge CB4 0FP, UK.
Zanotti-Gerosa
Antonio
A
Hems
William
W
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001952:Bridged-Ring Compounds; D008024:Ligands; D010720:Phosphines; C498380:paracyclophane phosphine