title: The case for insulin treatment early in type 2 diabetes.
abstract: Most patients with type 2 diabetes ultimately need insulin therapy. This paper presents the case for starting insulin therapy sooner rather than later, preferably without oral drugs and in a "basal/bolus" regimen consisting of a daily dose of a long-acting insulin for basal coverage plus preprandial doses of a short-acting insulin.
authors.affiliation: Mayo Clinic Scottsdale, Scottsdale, AZ 85259, USA. palumbo.pasquale@mayo.edu
authors.forename: Pasquale J
authors.initials: PJ
authors.lastname: Palumbo
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D018450:Disease Progression; D004334:Drug Administration Schedule; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin