[Detection of TCR-gamma chain gene rearrangement in malignant histiocytosis].
OBJECTIVE
To investigate the lineage of the malignant cells in malignant histiocytosis.


METHODS
Polymerase chain reaction with two groups of common primers for TCR-gamma gene was used to analyze the malignant cells of 28 autopsied cases of malignant histiocytosis.


RESULTS
Monoclonal TCR-gamma gene rearrangements were detected in 12 out of the 28 samples (43%).


CONCLUSIONS
Most cases diagnosed as malignant histiocytosis in Southwest China seems to be peripheral T-cell lymphomas.
Lu
Chang-li
CL
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Gan-di
GD
Liu
Wei-ping
WP
Guo
Jia
J
Li
Feng-yuan
FY
Liao
Dian-ying
DY
Zhang
Wen-yan
WY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019002:CD56 Antigen / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D015614:Histiocytosis / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D019002:CD56 Antigen