title: Radiolabeled annexin-V for monitoring treatment response in oncology.
abstract: Because of its potential to allow for noninvasive, repetitive, and selective in vivo identification of the site and extent of apoptotic cell death and for monitoring cell death kinetics without the need for invasive biopsy, radiolabeled annexin-V is of major clinical relevance. This paper reviews available preclinical and clinical data on radiolabeled annexin-V pertaining to the domain of monitoring response to radiotherapy and chemotherapy, focusing especially on advantages and drawbacks of the different labeling procedures for the radiolabeling of annexin-V.
authors.affiliation: Department of Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium. christophe.vandewiele@ugent.be
authors.forename: Christophe
authors.initials: C
authors.lastname: Van de Wiele
authors.forename: Hubert
authors.initials: H
authors.lastname: Vermeersch
authors.forename: David
authors.initials: D
authors.lastname: Loose
authors.forename: Alberto
authors.initials: A
authors.lastname: Signore
authors.forename: Nico
authors.initials: N
authors.lastname: Mertens
authors.forename: Rudi
authors.initials: R
authors.lastname: Dierckx
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000032:analysis*; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007553:Isotope Labeling / Q000379:methods*; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*
chemical_list: D017304:Annexin A5