title: [The polymorphism distributions of MICA and MICB microsatellite in Guangdong Han population].
abstract: OBJECTIVE
  To investigate the genetic polymorphism of microsatellite in the exon 5 of MICA gene and the intron 1 of MICB gene in Guangdong Han population.
  
  
  METHODS
  One hundred and six samples of Guangdong Han population were genotyped by polymerase chain reaction and fluorescent technique (6-FAM). Gene frequency, power of discrimination, expected heterozygosity, polymorphism information content and probability of paternity exclusion were calculated.
  
  
  RESULTS
  The genotype distributions of MICA and MICB microsatellite met Hardy-Weinberg equilibrium. MICA A5 was the most common allele (0.2877), whereas A4 was the least popular one (0.1321). The genotype distribution frequencies of A5-5.1 (14.15%) and A5-5 (10.38%) are high. MICB CA14 was the most common allele (0.3255), and CA19,28 was the least popular one (0.0047). CA27 was not observed. The genotype distribution frequency of CA14-CA14(14.15%) is high.
  
  
  CONCLUSIONS
  The microsatellite of the exon 5 of MICA gene and the intron 1 of MICB gene could be used as the genetic markers of Chinese population in the studies of anthropology, linkage analysis of genetic disease genes, individual identification and paternity test in forensic medicine.
authors.affiliation: Shanghai Blood Center, Shanghai, 200051 PR China. fengml@sh163.net
authors.forename: Ming-liang
authors.initials: ML
authors.lastname: Feng
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Zhang
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Yun
authors.initials: Y
authors.lastname: Ji
authors.forename: Qiong
authors.initials: Q
authors.lastname: Lu
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Jian-hao
authors.initials: JH
authors.lastname: Yang
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Guo
mesh_terms: D002681:China / Q000208:ethnology; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; C098080:MICB antigen