title: Decreased taste sensitivity in cancer patients under chemotherapy.
abstract: OBJECTIVE
  The aim of the study was to measure taste thresholds among cancer patients under chemotherapy compared to controls.
  
  
  METHODS
  The study was performed with 110 cancer patients and 170 healthy subjects of similar age distribution were included in the study. The electrogustometric detection threshold was evaluated as the lowest current intensity perceived by the subject in three tongue sites independently with a constant current generator.
  
  
  RESULTS
  Taste thresholds for all cancer patients demonstrated significantly higher values compared to controls.
  
  
  CONCLUSIONS
  Cancer patients treated by chemotherapy demonstrated a temporary taste sensitivity deficit. Associated with the illness due to the treatment, this deficit explains the patients complaining of "abnormal or bad tastes", which results in food aversion and has a negative impact on nutritional status and quality of life. In order to prevent the risk of anorexia and the enhanced morbidity related to this deficit, treatment should include relevant information to the subject for anticipating objective taste modifications and a psychological follow-up during the actual change of taste quality perceptions in everyday life.
authors.affiliation: Faculté de Chirurgie Dentaire, 5 Rue Garancière, 75006 Paris, France. berteret@ccr.jussieu.fr
authors.forename: M V
authors.initials: MV
authors.lastname: Berteretche
authors.forename: A M
authors.initials: AM
authors.lastname: Dalix
authors.forename: A M Cesar
authors.initials: AM
authors.lastname: d'Ornano
authors.forename: F
authors.initials: F
authors.lastname: Bellisle
authors.forename: D
authors.initials: D
authors.lastname: Khayat
authors.forename: A
authors.initials: A
authors.lastname: Faurion
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy; D011788:Quality of Life; D013651:Taste Disorders / Q000139:chemically induced*; D013652:Taste Threshold
chemical_list: D000970:Antineoplastic Agents