[Introduction of dimephosphon in the early stage of pregnancy and its effect on the rat progeny].
Some anticholinesterase organophosphorus compounds introduced into the organism in the course of pregnancy lead to the development of behavioral and morphological disturbances in both human and animal kids. In this context, the potential teratogenic effect of dimephosphon (1,1-dimethyl-3-ketobutylphosphonic acid dimethyl ester), representing nonanticholinesterase derivatives of organophosphoric acids, was evaluated in rats. The drug was introduced in a dose of 200 mg/kg over the period from 1st to 6th day of pregnancy and the results were assessed on the 20th day. It was found that dimephosphon did not lead to the loss of embryos. The results of morphological investigation showed neither anomalies in the development of embryo nor evidence of changes in the sex differentiation. Thus, dimephosphon exhibited no teratogenicity upon introduction in the early stage of pregnancy in rats.
Burykin
I M
IM
Pharmacology Department, State Medical University, ul. Butlerova 49, Kazan, Tatarstan, 420012 Russia.
Aleeva
G N
GN
Khafiz'ianova
R Kh
RKh
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D009943:Organophosphorus Compounds / Q000009:adverse effects*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats
D009943:Organophosphorus Compounds; C049638:dimephosphon