Human challenge pilot study with Cyclospora cayetanensis.
We describe a pilot study that attempted to infect human volunteers with Cyclospora cayetanensis. Seven healthy volunteers ingested an inoculum of Cyclospora oocysts (approximately 200-49,000 oocysts). The volunteers did not experience symptoms of gastroenteritis, and no oocysts were detected in any stool samples during the 16 weeks volunteers were monitored.
Alfano-Sobsey
Edith M
EM
Office of Public Health Preparedness and Response, Raleigh, North Carolina, USA. ealfano@ph.co.durham.nc.us
Eberhard
Mark L
ML
Seed
John R
JR
Weber
David J
DJ
Won
Kimberly Y
KY
Nace
Eva K
EK
Moe
Christine L
CL
D000328:Adult; D000818:Animals; D021744:Cyclospora / Q000302:isolation & purification; D021866:Cyclosporiasis / Q000209:etiology*; D005243:Feces / Q000469:parasitology; D006801:Humans; D008875:Middle Aged; D033661:Oocysts / Q000302:isolation & purification; D010865:Pilot Projects