Comparison of frequency of interferon-gamma-positive CD4+ T cells before and after percutaneous coronary intervention and the effect of statin therapy in patients with stable angina pectoris.
We investigated the effect of statin therapy on T-cell activation in patients who underwent percutaneous coronary intervention by using flow cytometric analysis. The increased frequency of interferon-gamma-positive CD4(+) T cells after percutaneous coronary intervention was significant in the group treated without statins but not in the group treated with statins.
Tanaka
Tomoko
T
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan.
Soejima
Hirofumi
H
Hirai
Nobutaka
N
Sakamoto
Tomohiro
T
Yoshimura
Michihiro
M
Kajiwara
Ichiro
I
Miyao
Yuji
Y
Fujimoto
Kazuteru
K
Miyagi
Hiroo
H
Irie
Atsushi
A
Nishimura
Yasuharu
Y
Ogawa
Hisao
H
D000368:Aged; D000787:Angina Pectoris / Q000276:immunology / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000276:immunology / Q000628:therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007371:Interferon-gamma