A notable antimutagenicity of two nonmutagenic novel oxadiazoles in Salmonella mutagenicity assay.
The mutagenic activity of two newly synthesized oxadiazoles: 1,3-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene (M1) and 1,4-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene (M2) was studied in Salmonella typhimurium strains TA97, TA100, TA102 and TA1537 in the presence and absence of S9mix. The antimutagenicity of M1 and M2 against H2O2, sodium azide (SA) and 4-nitro-o-phenylene diamine (NPD) using the tester strains TA102, TA100 and TA97, respectively, was also investigated. The two compounds were found to be nonmutagenic using the four tester strains. However, they showed high mutagenic repression activity against hydrogen peroxide (95% and 97% for M1 and M2, respectively, at a concentration of 335 micrograms/plate). Moderate mutagenic repression against NPD (58% and 55% for M1 and M2, respectively, at a concentration of 167.5 micrograms/plate) and low mutagenic repression against SA (21% and 33% for M1 and M2 respectively, at a concentration of 335 micrograms/plate) was detected. The obtained results are very encouraging to test the above mentioned compounds as anticarcinogens.
Maslat
Ahmed
A
Department of Biological Sciences, Yarmouk University, P.O. Box 4538, 211-63 Irbid, Jordan. mass7000@yahoo.com
Khalil
Ahmad
A
Fares
Ahmed
A
Tashtoush
Hasan
H
el-Talib
Mahmoud
M
D016587:Antimutagenic Agents / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000037:antagonists & inhibitors / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D010069:Oxadiazoles / Q000494:pharmacology*; D016877:Oxidants; D010655:Phenylenediamines / Q000037:antagonists & inhibitors; D012486:Salmonella typhimurium / Q000187:drug effects*; D019810:Sodium Azide / Q000037:antagonists & inhibitors / Q000633:toxicity
C495850:1,3-bis(5-benzylthio-1,3,4-oxadiazol-2-yl)benzene; C495851:1,4-bis(5-benzylthio-1,3,4-oxadiazol-2-yl) benzene; D016587:Antimutagenic Agents; D009153:Mutagens; D010069:Oxadiazoles; D016877:Oxidants; D010655:Phenylenediamines; C012277:1,2-diamino-4-nitrobenzene; D019810:Sodium Azide; D006861:Hydrogen Peroxide