Perinatal stroke in term infants with neonatal encephalopathy.
In a prospective cohort of 124 encephalopathic term infants, six infants had an acute focal stroke. All six encephalopathic patients with strokes presented with seizures. Neurodevelopmental outcome at 30 months was abnormal in all six patients and significantly worse when compared with the entire cohort overall. These findings suggest that in newborns with encephalopathy, acute focal strokes are an uncommon but serious occurrence with substantial risk for abnormal neurodevelopmental outcome.
Ramaswamy
V
V
Department of Neurology, University of California San Francisco, CA 94143-0663, USA.
Miller
S P
SP
Barkovich
A J
AJ
Partridge
J C
JC
Ferriero
D M
DM
D000328:Adult; D001034:Apgar Score; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology; D001927:Brain Diseases / Q000150:complications / Q000151:congenital*; D002544:Cerebral Infarction / Q000453:epidemiology* / Q000209:etiology; D002547:Cerebral Palsy / Q000453:epidemiology / Q000209:etiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008471:Meconium Aspiration Syndrome / Q000150:complications; D007744:Obstetric Labor Complications / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011446:Prospective Studies; D012306:Risk; D012640:Seizures / Q000453:epidemiology / Q000209:etiology; D012720:Severity of Illness Index; D016037:Single-Blind Method