Transcriptional regulation of interleukin 2 in SLE T cells.
Interleukin-2 (IL-2) is a central cytokine required for the activation of T, B, and NK cells. It propagates the immune response and terminates it by promoting the activation induced cell death of T cells. IL-2 production is altered in T cells of patients with systemic lupus erythematosus (SLE). The consequence of reduced IL-2 production in SLE is decreased immune response to infectious agents. Decreased IL-2 production by SLE T cells is the result of transcriptional repression of the IL-2 gene. This article will review the defective transcription regulation of IL-2 in SLE T cells, which is the result of decreased expression of the enhancers NF-kappa B and AP1 and the increased expression of the transcriptional repressor CREM.
Tenbrock
Klaus
K
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Tsokos
George C
GC
D005786:Gene Expression Regulation; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics* / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D014158:Transcription, Genetic
D007376:Interleukin-2