Factor V Leiden mutation in pregnancy.
Normal maternal adaptation to pregnancy significantly increases the risk for thrombus formation. Inherited thrombophilias further increase risk for deep venous thrombosis and adverse outcome in pregnancy. Factor V Leiden mutation is the most common inherited thrombophilia, occurring in approximately 5% of the White and 1% of the Black populations. Nurses should be knowledgeable about screening for and diagnosis of factor V Leiden mutation, risk reduction counseling, recommended care of the affected patient, and implications of anticoagulant therapy during the perinatal period.
Cohen
Susan Murphy
SM
D020016:Activated Protein C Resistance / Q000235:genetics / Q000451:nursing; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics / Q000517:prevention & control; D006801:Humans; D015404:Nursing Methodology Research; D009773:Obstetric Nursing / Q000592:standards; D010353:Patient Education as Topic / Q000379:methods; D017354:Point Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000451:nursing; D011250:Pregnancy Complications, Hematologic / Q000451:nursing; D011256:Pregnancy Outcome; D012307:Risk Factors; D013923:Thromboembolism / Q000235:genetics / Q000451:nursing; D020246:Venous Thrombosis / Q000235:genetics / Q000451:nursing
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V