Chromosome imbalances in oligodendroglial tumors detected by comparative genomic hybridization.
Seven well-differentiated oligodendrogliomas, 16 anaplastic oligodendrogliomas and two cases of oligoastrocytomas were investigated by comparative genomic hybridization (CGH) on frozen tissue samples. The most frequent losses found involved 1p and 19q in 32% of cases. Loss of 9p was observed during malignant progression in 25% of anaplastic oligodendrogliomas. In two anaplastic oligodendrogliomas gain of 1q was found. The frequent losses of chromosome 16 and 22 have not been reported previously. These results underscore that CGH is a powerful tool for the classification of gliomas complementing the traditional histopathological approach.
Bourdon
Violaine
V
Laboratoire de Génétique-EA3441, CHU Nancy-Brabois, avenue du Morvan, 54111 Vandoeuvre les Nancy, France.
Plessis
Ghislaine
G
Chapon
Françoise
F
Guarnieri
José
J
Derlon
Jean Michel
JM
Jonveaux
Philippe
P
D001254:Astrocytoma / Q000235:genetics*; D001932:Brain Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D017403:In Situ Hybridization; D009837:Oligodendroglioma / Q000235:genetics*