Combination chemotherapy with 5-fluorouracil and heptaplatin as first-line treatment in patients with advanced gastric cancer.
Heptaplatin is a recently developed platinum derivative. This agent has been reported to have a response rate of 17% as a single agent, and tolerable toxicity in the treatment of advanced gastric cancer. The aim of this study was to evaluate the efficacy and toxicity of a combination of 5-fluorouracil (5-FU) and heptaplatin in patients with advanced gastric cancer. Forty-seven chemotherapy-naive patients with advanced or recurred gastric cancer were recruited. 5-FU was administered over 120 hr by continuous intravenous infusion from day 1 to 5, at a daily dose of 1,000 mg/m2 and heptaplatin was administered over 1 hr by intravenous infusion on day 1 at 400 mg/m2, and this cycle was repeated every 4 weeks. The response rate was 21%, median progression-free survival was 1.9 months (95% CI, 1.6 to 2.2 months). Median overall survival was 6.2 months (95% CI, 4 to 8.4 months) and the 1-yr survival rate was 29% for all patients. The most frequent toxicity was proteinuria. Toxicities were generally mild and reversible. This study demonstrates that the combination of 5-FU/heptaplatin combination is less active but tolerated in patients with advance gastric cancer.
Min
Young Joo
YJ
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. yjmin@uuh.ulsan.kr
Bang
Sung-Jo
SJ
Shin
Jung Woo
JW
Kim
Do Ha
DH
Park
Jae Hoo
JH
Kim
Gyu Yeol
GY
Ko
Byung Kyun
BK
Choi
Dae Hwa
DH
Cho
Hong Rae
HR
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008314:Malonates / Q000008:administration & dosage*; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D013274:Stomach Neoplasms / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
D008314:Malonates; D009944:Organoplatinum Compounds; C090717:SKI 2053R; D005472:Fluorouracil