title: The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
abstract: In the following three sections, we will briefly review the seminal roles of the HIV-1 nucleocapsid protein p7 (NCp7) in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase (RT) in the course of proviral DNA synthesis and to DNA integrity at the end of the polymerization process, and to the NC-assisted repair and recombination reactions fueling the viability and variability of the virus.
authors.affiliation: LaboRetro, Unité de Virologie Humaine, INSERM #412, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69 364 Lyon, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Bampi
authors.forename: Sandrine
authors.initials: S
authors.lastname: Jacquenet
authors.forename: Daniela
authors.initials: D
authors.lastname: Lener
authors.forename: Didier
authors.initials: D
authors.lastname: Décimo
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Darlix
mesh_terms: D000595:Amino Acid Sequence; D036022:Capsid Proteins / Q000502:physiology*; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis*; D015683:Gene Products, gag / Q000502:physiology*; D014644:Genetic Variation; D016325:HIV Long Terminal Repeat; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D008969:Molecular Sequence Data; D019590:Nucleocapsid Proteins; D012357:RNA, Transfer, Lys / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011995:Recombination, Genetic; D014764:Viral Proteins / Q000502:physiology*; D054301:gag Gene Products, Human Immunodeficiency Virus
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; D015683:Gene Products, gag; D018832:Molecular Chaperones; C071884:NCP7 protein, Human immunodeficiency virus 1; D019590:Nucleocapsid Proteins; D012357:RNA, Transfer, Lys; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus