The interplay of fold recognition and experimental structure determination in structural genomics.
Achieving the goals of structural genomics initiatives depends on the outcomes of two groups of factors: the number and distribution of experimentally determined protein structures, and our ability to assign novel proteins to known structures (fold recognition) and use them to build models (modeling). The quality of the tools used for fold recognition defines the scope of experimental effort - the more distant the templates that can be recognized, the smaller the number of proteins that have to be solved. Recent improvements in fold recognition may have suggested that the goals of structural genomics initiatives are getting closer. However, problems that surfaced during the first few years of active work have put many of the early estimates in doubt and new ones are still slow in coming.
Friedberg
Iddo
I
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Jaroszewski
Lukasz
L
Ye
Yuzhen
Y
Godzik
Adam
A
D000818:Animals; D023281:Genomics / Q000379:methods; D006801:Humans; D008958:Models, Molecular; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
D011506:Proteins