title: The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
abstract: 3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. jeffrey_hale@merck.com
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Hale
authors.forename: George
authors.initials: G
authors.lastname: Doherty
authors.forename: Leslie
authors.initials: L
authors.lastname: Toth
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Sander G
authors.initials: SG
authors.lastname: Mills
authors.forename: Richard
authors.initials: R
authors.lastname: Hajdu
authors.forename: Carol
authors.initials: C
authors.lastname: Ann Keohane
authors.forename: Mark
authors.initials: M
authors.lastname: Rosenbach
authors.forename: James
authors.initials: J
authors.lastname: Milligan
authors.forename: Gan-Ju
authors.initials: GJ
authors.lastname: Shei
authors.forename: Gary
authors.initials: G
authors.lastname: Chrebet
authors.forename: James
authors.initials: J
authors.lastname: Bergstrom
authors.forename: Deborah
authors.initials: D
authors.lastname: Card
authors.forename: Hugh
authors.initials: H
authors.lastname: Rosen
authors.forename: Suzanne
authors.initials: S
authors.lastname: Mandala
mesh_terms: D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D063065:Organophosphonates / Q000138:chemical synthesis; D009943:Organophosphorus Compounds / Q000138:chemical synthesis; D010761:Phosphorus Radioisotopes; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D049349:Receptors, Lysosphingolipid / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010761:Phosphorus Radioisotopes; D043562:Receptors, G-Protein-Coupled; D049349:Receptors, Lysosphingolipid