[Glycosaminoglycans, proteoglycans, atherosclerosis].
Glycosaminoglycans, proteoglycans have fundamental roles in the building up of the vascular walls. The research work of the correlations between glycosaminoglycans, proteoglycans and the pathogenesis of atherosclerosis was since more decades proceeding. The prominent experts of the scope are paying more and more attention to the significant influence of the inflammation ongoing in the arterial vessel wall. Glycosaminoglycans, proteoglycans are equally contributing to the development, stopping or remaining, turning into chronic type of the inflammatory process. On the ground of all these this article makes an attempt to outline, using up the newest results of the investigations being in relation with the fundamental structures, the alterations in the composition, the occurrences, the essential functions of the glycosaminoglycans, proteoglycans. Afterwards the diverse important roles of these molecular organizations played in the pathogenesis, in the progression of atherosclerosis, and in the arising of its complications are surveyed. Basing on the considerable data of the observations it can be established that glycosaminoglycans, proteoglycans have determining importance in the individual, peculiar inflammation progressing in the arterial vessel wall, in the surviving of the special vasculitis, in the appearance of atherosclerosis, in the focal nature and progression of that and in the development of its complications. The knowledge becoming continuously more complete affords, a long-range expectation in relation to both the prevention and therapeutic intervention of that widespread disease.
Jakab
Lajos
L
Semmelweis Egyetem, Altalános Orvostudományi Kar, III. Belgyógyászati Klinika, Budapest.
D001161:Arteriosclerosis / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D011509:Proteoglycans / Q000378:metabolism*
D006025:Glycosaminoglycans; D008074:Lipoproteins; D011509:Proteoglycans; D006820:Hyaluronic Acid