Spider and wasp neurotoxins: pharmacological and biochemical aspects.
Venoms from several arthropods are recognized as useful sources of bioactive substances, such as peptides, acylpolyamines, and alkaloids, which show a wide range of pharmacological effects on synaptic transmission. In this work, we summarize and compile several biochemical and pharmacological aspects related to spider and wasp neurotoxins. Their inhibitory and stimulatory actions on ion channels, receptors, and transporters involved in mammalian and insect neurotransmission are considered.
de O Beleboni
Renê
R
Department of Biochemistry and Immunology, School of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil.
Pizzo
Andrea B
AB
Fontana
Andréia C K
AC
de O G Carolino
Ruither
R
Coutinho-Netto
Joaquim
J
Dos Santos
Wagner F
WF
D000818:Animals; D001938:Brazil; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D009498:Neurotoxins / Q000737:chemistry* / Q000494:pharmacology*; D015222:Sodium Channels / Q000502:physiology; D013111:Spider Venoms / Q000737:chemistry*; D014862:Wasp Venoms / Q000737:chemistry*
D009498:Neurotoxins; D015222:Sodium Channels; D013111:Spider Venoms; D014862:Wasp Venoms