The single-step synthesis of a DNA tetrahedron.
A tetrahedral nanostructure whose edges are DNA double helices self-assembles spontaneously when four appropriately designed oligonucleotides are annealed together in solution; the ease of synthesis, rigidity, and adaptability of this construct make it a promising candidate as a cage for other large molecules and as a building block for more complicated nanostructures.
Goodman
Russell P
RP
University of Oxford, Department of Physics, Clarendon Laboratory, Parks Road, Oxford, UKOX1 3PU. russell.goodman@physics.ox.ac.uk
Berry
Richard M
RM
Turberfield
Andrew J
AJ
D001483:Base Sequence; D004247:DNA / Q000138:chemical synthesis* / Q000235:genetics; D019281:Dimerization; D008958:Models, Molecular; D008969:Molecular Sequence Data; D049329:Nanostructures; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry
D009841:Oligonucleotides; D004247:DNA