title: Clinical and immunologic aspects of cancer-associated retinopathy.
abstract: OBJECTIVE
  To report clinical and immunologic aspects of cancer-associated retinopathy (CAR).
  
  
  METHODS
  Observational consecutive case series.
  
  
  METHODS
  A retrospective review was made of 18 consecutive patients with cancer-associated retinopathy who had antiretinal antibody determination by Western blot testing.
  
  
  RESULTS
  Clinically, a variety of ophthalmic observations including electroretinography impairment, retinal vessel narrowing, deterioration of visual acuity, visual field changes, and uveitis were frequently observed. As retinal autoantigens in the 18 cases, recoverin was found in all 18 cases (100%), heat shock cognate protein 70 (HSC70) was found in six cases (33%), and other proteins were found in four cases (20%). These antibodies were detected in only 60% of the patients at the initial examination, however, and then became increasingly apparent on the subsequent testing that was performed three times on serum samples obtained sequentially during the following months.
  
  
  CONCLUSIONS
  For diagnosis of cancer-associated retinopathy, the presence of serum autoantibody toward recoverin is essentially required in addition to the characteristic clinical aspects noted above.
authors.affiliation: Department of Ophthalmology, Hirosaki University School of Medicine, Hirosaki, Aomoriken, Japan. ooguro@cc.hirosaki-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohguro
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yokoi
authors.forename: Ikuyo
authors.initials: I
authors.lastname: Ohguro
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mamiya
authors.forename: Futoshi
authors.initials: F
authors.lastname: Ishikawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Tomomi
authors.initials: T
authors.lastname: Metoki
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takano
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ito
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakazawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D015153:Blotting, Western; D002135:Calcium-Binding Proteins / Q000276:immunology*; D005136:Eye Proteins; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D051603:Recoverin; D012174:Retinitis Pigmentosa / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D018840:HSP70 Heat-Shock Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin