Differential effects of spontaneous versus forced exercise in rats on the staining of parvalbumin-positive neurons in the hippocampal formation.
To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an immunocytochemical study using the parvalbumin (PV) distribution as a marker. Animals submitted to the voluntary exercise were placed in a voluntary wheel running and those submitted to the forced exercise were placed in a motor driven treadmill. Both exercise groups were submitted to 10 consecutive days of physical activity. It was observed a higher number of PV-positive cells in the hilus of dentate gyrus (DG) in the voluntary and forced exercise groups when compared to the control group. The voluntary exercise group also presented a stronger fiber staining in the DG hilus than the forced exercise and control groups. In contrast, no differences were found in the pattern of PV staining in CA1/CA3 region between exercise and control groups. These findings demonstrate that physical activity leads to prominent plastic changes in the hippocampal formation of rats that were more evident following voluntary activity.
Arida
Ricardo Mario
RM
Laboratório de Neurologia Experimental, Universidade Federal de São Paulo-Escola Paulista de Medicina, Rua Botucatú 862, Vila Clementino, CEP 04023-900 São Paulo, Brazil. arida.nexp@epm.br
Scorza
Carla Alessandra
CA
da Silva
Alexandre Valotta
AV
Scorza
Fulvio Alexandre
FA
Cavalheiro
Esper Abrão
EA
D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D007150:Immunohistochemistry; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010320:Parvalbumins / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D010320:Parvalbumins