title: Survey of ferroxidase expression and siderophore production in clinical isolates of Pseudomonas aeruginosa.
abstract: Ferroxidase (encoded by the mco gene), a component of a ferrous iron uptake pathway in Pseudomonas aeruginosa, was detected in all of the 35 respiratory clinical isolates surveyed; in contrast, considerable variation in siderophore expression was observed. The ubiquitous expression of this periplasmic ferroxidase suggests that it plays a key role in iron uptake in this opportunistic pathogen.
authors.affiliation: Centre for Metals in Biology, Department of Microbiology and Parasitology, School of Molecular and Microbial Sciences, University of Queensland, St Lucia, 4072, Queensland, Australia.
authors.forename: Wilhelmina M
authors.initials: WM
authors.lastname: Huston
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Potter
authors.forename: Michael P
authors.initials: MP
authors.lastname: Jennings
authors.forename: Jordi
authors.initials: J
authors.lastname: Rello
authors.forename: Alan R
authors.initials: AR
authors.lastname: Hauser
authors.forename: Alastair G
authors.initials: AG
authors.lastname: McEwan
mesh_terms: D002570:Ceruloplasmin / Q000032:analysis*; D006801:Humans; D007501:Iron / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D017262:Siderophores / Q000096:biosynthesis*
chemical_list: D017262:Siderophores; D007501:Iron; D010088:Oxidoreductases; C024748:copper oxidase; D002570:Ceruloplasmin