Cyclosporine increases endothelin-1 plasma levels in renal transplant recipients.
Endothelin-1 (ET-1) has been associated with the development of hypertension in cyclosporine-treated renal transplant recipients. To clarify this association, this observational study compared ET-1 levels in 33 patients taking cyclosporine therapy versus 10 controls. Three hours after cyclosporine administration, ET-1 levels were higher than in the controls, namely 1.81 + 0.99 versus 1.17 + 0.46 pg/mL (P <.04). These results suggest a role of ET-1 in the pathogenesis of post-renal transplantation hypertension in cyclosporine-treated recipients.
Cauduro
R L
RL
Renal Division, Hospital de Clínicas de Porto Alegre and Post-Graduation in Medical Sciences, Nephrology Program, Rio Grande do Sul Federal University, Porto Alegre, RS, Brazil.
Costa
C
C
Lhulier
F
F
Garcia
R G
RG
Cabral
R D
RD
Gonçalves
L E
LE
Manfro
R C
RC
D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology; D016030:Kidney Transplantation / Q000276:immunology*; D007700:Kinetics; D008297:Male; D013997:Time Factors
D019332:Endothelin-1; D016572:Cyclosporine; D001379:Azathioprine