Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
Taourirte
M
M
Faculty of Sciences and Techniques Gueliz, Marrakesh, Morocco.
Mohamed
L Ait
LA
Rochdi
A
A
Vasseur
J J
JJ
Fernández
S
S
Ferrero
M
M
Gotor
V
V
Pannecouque
C
C
De Clercq
E
E
Lazrek
H B
HB
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D019281:Dimerization; D005656:Fungal Proteins / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D008049:Lipase / Q000737:chemistry*; D018119:Stavudine / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000138:chemical synthesis* / Q000494:pharmacology
D019380:Anti-HIV Agents; D005656:Fungal Proteins; D015215:Zidovudine; D018119:Stavudine; D008049:Lipase; C431349:lipase B, Candida antarctica