[Influence of chronic epilepsy on spatial memory retrieval in rats].
To investigate the influence of chronic epilepsy on spatial memory retrieval in rats, and to evaluate the effects of TAK-147, an acetylcholinesterase inhibitor, and histidine, the precursor of histamine, on the amnesia induced by epilepsy.



After successfully trained in the 8-arm (4-arm baited) radial maze, the rats were ip injected with a subconvulsive dose of pentylenetetrazole (PTZ) every 48 h until fully kindled. Memory retrieval was tested at the same maze.



Impairment of memory retrieval was in a steady state 1 to 18 days after fully kindled, the ability of memory retrieval returned to the control level 31 days after fully kindled. TAK-147 showed an ameliorating effect on memory impairment induced by epilepsy, including reference and working memory in a dose-dependent manner. Histidine only ameliorated reference but not working memory.



PTZ-kindled seizure impair spatial memory retrieval, which it might be due to a decrease of brain acetylcholine and histamine induced by epilepsy.
Zhang
Li-san
LS
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Jin
Chu-lei
CL
Li
Qing
Q
Sun
Yong-cheng
YC
Chen
Zhong
Z
D000818:Animals; D001552:Benzazepines / Q000627:therapeutic use; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000523:psychology*; D008297:Male; D018782:Maze Learning; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology*; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley
D001552:Benzazepines; C099872:TAK 147; D010433:Pentylenetetrazole