Linear deposition of immunoglobulins and complement components on the dura in normal pressure hydrocephalus complicating systemic lupus erythematosus.
We present a case of normal pressure hydrocephalus in a 70-year-old man with previously diagnosed systemic lupus erythematosus. Histological examination demonstrated the linear deposition of IgG, IgA, IgM, C(3) and C(1q) on the dura in the absence of inflammation or thrombosis that has previously been implicated in the aetiology of elevated pressure hydrocephalus in systemic lupus erythematosus. Our results suggest that the deposition of immunoglobulins and complement may play a pivotal role in an insidious manner in the pathogenesis of normal pressure hydrocephalus in systemic lupus erythematosus.
Honda
Kazuhiro
K
Department of Neurology, Hikone Municipal Hospital, Japan. hxk54@cwru.edu
Matsumoto
Masao
M
Kaneko
Takaaki
T
Kamei
Ichiro
I
Tatsumi
Hiroyuki
H
Murai
Nozomu
N
Mineharu
Yohei
Y
Oita
Jiro
J
D000368:Aged; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications / Q000276:immunology / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000276:immunology / Q000378:metabolism; D008297:Male
D007136:Immunoglobulins; D003165:Complement System Proteins