title: Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses.
abstract: In this study, for the first time, we investigated about the localization of VEGF-A, VEGFR-2 and Ang-2 in the choroid plexuses of the adult mouse by Western blot and immunohistochemistry. Results showed that VEGF-A stained epithelial cells, while anti-VEGFR-2 and -Ang-2 antibodies stained endothelial cells. These data suggest that Ang-2, converting blood vessels into a more plastic and immature phenotype, would provide more accessibility of VEGF-A to endothelial cells.
authors.affiliation: Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I-70124, Bari, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.forename: Domenica
authors.initials: D
authors.lastname: Mangieri
authors.forename: Patrizia
authors.initials: P
authors.lastname: Corsi
authors.forename: Michela
authors.initials: M
authors.lastname: De Giorgis
authors.forename: Angelo
authors.initials: A
authors.lastname: Vacca
authors.forename: Luisa
authors.initials: L
authors.lastname: Roncali
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D000367:Age Factors; D042702:Angiopoietin-2 / Q000378:metabolism*; D000818:Animals; D002831:Choroid Plexus / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
chemical_list: D042702:Angiopoietin-2; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2