A novel in vivo procedure for volumetric flow measurements.
We report on a novel procedure for invasive volumetric blood flow measurements using a commercially available Doppler flow wire system, which could, until now, only measure flow velocity. We here describe a method applicable in vivo to generate both velocity and cross-sectional area information from the same pulsed-wave Doppler signal for volumetric flow assessment. We demonstrate its feasibility and validation in vivo in pig coronary arteries. Our Doppler-derived volumetric flow measurements were compared with the respective transit-time flow and showed an excellent correlation (r = 0.969; p < 0.0001). Agreement between transit-time and Doppler-derived flow measurements could be observed for flow conditions ranging from 30 to 180 mL/min. The mean values for the two methods were 71.4 +/- 43.7 mL/min and 71.3 +/- 42.2 mL/min, respectively. We conclude that this technique might possibly be introduced into future clinical practice as an invasive procedure of choice for the assessment of volumetric blood flow.
Jenni
Rolf
R
Echocardiography, Division of Cardiology, Cardiovascular Center, University Hospital, Zurich, Switzerland. karjer@usz.unizh.ch
Matthews
Felix
F
Aschkenasy
Schlomo V
SV
Lachat
Mario
M
van Der Loo
Bernd
B
Oechslin
Erwin
E
Namdar
Mehdi
M
Jiang
Zhihua
Z
Kaufmann
Philipp A
PA
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D018619:Echocardiography, Doppler, Pulsed / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D012039:Regional Blood Flow; D013552:Swine