Cell motility: Golgi signalling shapes up to ship out.
In a motile eukaryotic cell, secretory traffic is directed towards the front of the cell. New work shows that signals from the Golgi matrix play an important part in cell motility by allowing reorientation of the Golgi towards the direction of movement.
Mellor
Harry
H
Mammalian Cell Biology Laboratory, Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK. h.mellor@bristol.ac.uk
D001324:Autoantigens; D002465:Cell Movement / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D022101:Microtubule-Organizing Center / Q000502:physiology*; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D000099317:Hippo Kinases
D001324:Autoantigens; D008565:Membrane Proteins; D017346:Protein Serine-Threonine Kinases; C097741:Golgin subfamily A member 2; C430908:STK26 protein, human; D000099317:Hippo Kinases