Vaccination as a treatment for breast or ovarian cancer.
The immune system recognizes breast and ovarian cancer cells but whether it is effective in controlling these cancers in patients has yet to be proven. The challenge with vaccination strategies is to break tolerance so that the patient's immune system will recognize cancer cells. The success of vaccines depends on the identification of appropriate tumor antigens, establishment of effective immunization strategies and their ability to circumvent inhibitory immune mechanisms.
Holmberg
Leona A
LA
Department of Medicine, University of Washington School of Medicine, and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. lholmber@fhcrc.org
Sandmaier
Brenda
B
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods*
D019496:Cancer Vaccines