Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation.
A poor supply of oxygen and glucose to the brain can cause severe brain damage. Therefore, neuroprotective drugs against ischemia need to be developed. In this study, wogonin, a flavone found in Scutellaria baicalensis, had a protective effect on neuronal cells damaged by oxygen and glucose deprivation in rat hippocampal slices in culture. In particular, the protective effect on the pyramidal cell layer was significant. On the basis of these experimental results, wogonin may be a therapeutic agent for treating ischemia in patients.
Son
Dongwook
D
R&D Center for Functional Foods, Institute of Food and Culture, Pulmuone Co. Ltd., Soul, South Korea.
Lee
Pyeongjae
P
Lee
Jongseok
J
Kim
Hocheol
H
Kim
Sun Yeou
SY
D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D015687:Cell Hypoxia / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D044950:Flavanones / Q000494:pharmacology* / Q000627:therapeutic use; D005544:Forecasting; D005947:Glucose / Q000009:adverse effects / Q000172:deficiency / Q000502:physiology; D007723:Korea; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects* / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D046509:Tissue Culture Techniques / Q000379:methods
D044950:Flavanones; D018696:Neuroprotective Agents; D005947:Glucose; C085514:wogonin