[Experimental pharmacokinetics of phenazepam during transdermal administration of the therapeutic phenaperkuten system].
The pharmacokinetics of fenazepam upon application of the transdermal therapeutic system (TTS) fenapercuten in various forms and under different conditions was studied in rabbits. The rate of the transdermal transfer of fenazepam from TTS to blood varied from 0.76 to 2.89 mg/(ml cm2). It was found that the drug transfer rate remains constant for 2-3 days. After removal of the TTS, fenazepam is eliminated within 3 days.
Litvin
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Laboratory of Pharmacokinetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
D000279:Administration, Cutaneous; D000818:Animals; D001569:Benzodiazepines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D008297:Male; D011817:Rabbits; D014149:Tranquilizing Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D003692:Delayed-Action Preparations; D014149:Tranquilizing Agents; D001569:Benzodiazepines; C017928:phenazepam