title: Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae).
abstract: The aqueous and ethanol extracts of the dry leaves of Kalanchoe crenata (300 and 600 mg/kg) were evaluated for their analgesic properties on the pain induced by acetic acid, formalin and heat in mice and by pressure on rats. The ethanol extract of K. crenata at a dose of 600 mg/kg produced an inhibition of 61.13% on pain induced by acetic acid and 50.13% for that induced by formalin. An inhibition of 67.18% was observed on pain induced by heat 45 min after the administration of the extract. The aqueous extract administered at a dose of 600 mg/kg produced a maximum effect of 25% on pain induced by pressure. These activities were similar to those produced by a paracetamol-codeine association, while indomethacin exhibited a protective effect only against the writhing test. Our results suggest that the leaves of K. crenata could be a source of analgesic compounds.
authors.affiliation: Department of Animal Biology, Faculty of Science, University of Dschang, BP 67 Dschang, Cameroon.
authors.forename: T B
authors.initials: TB
authors.lastname: Nguelefack
authors.forename: A L
authors.initials: AL
authors.lastname: Fotio
authors.forename: P
authors.initials: P
authors.lastname: Watcho
authors.forename: S L
authors.initials: SL
authors.lastname: Wansi
authors.forename: T
authors.initials: T
authors.lastname: Dimo
authors.forename: A
authors.initials: A
authors.lastname: Kamanyi
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005557:Formaldehyde; D006358:Hot Temperature; D031962:Kalanchoe; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D005557:Formaldehyde; D019342:Acetic Acid