Biomarkers of hypoxic brain injury in the neonate.
The specific pathologic processes preceding the onset of irreversible cerebral injury seem to be a combination of several complex mechanisms due to the severity and duration of the insult to the biochemical modifications in the brain. An early diagnosis of the newborn at high risk for brain damage is relevant for preventive programs. Neuroprotective strategies will benefit from the detection of biochemical markers with high reliability and predictability for brain injury.
Buonocore
Giuseppe
G
Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, V.le Bracci, 36, 53100 Siena, Italy. buonocore@unisi.it
Perrone
Serafina
S
D028341:Activins / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D015415:Biomarkers / Q000032:analysis*; D001925:Brain Damage, Chronic / Q000209:etiology; D005315:Fetal Diseases / Q000378:metabolism; D005311:Fetal Hypoxia / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D002534:Hypoxia, Brain / Q000378:metabolism*; D020925:Hypoxia-Ischemia, Brain / Q000150:complications; D007239:Infections / Q000378:metabolism; D028322:Inhibin-beta Subunits / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D013574:Synaptosomes / Q000378:metabolism
D015415:Biomarkers; D005609:Free Radicals; D009419:Nerve Tissue Proteins; C422405:activin A; D028341:Activins; D028322:Inhibin-beta Subunits; D007501:Iron