Breaking in a new function for casein kinase 2.
DNA damage response mechanisms help ensure the fidelity of chromosomal transmission, and the failure of such mechanisms might lead to premature aging and cancer. A new report has established that casein kinase 2 (CK2), a protein that functions in diverse cellular processes, controls the activity of the DNA repair protein XRCC1. These results indicate that CK2 is a key participant in the cellular response to DNA damage.
Morales
Julio C
JC
Department of Biochemistry and Molecular Biology, University of California, University of Texas-Houston Medical School, Houston, TX 77225, USA.
Carpenter
Phillip B
PB
D000818:Animals; D047390:Casein Kinase II; D004260:DNA Repair / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases