title: Heterogeneous planning for homogeneous protocols.
abstract: Clinical trials often require homogeneous treatment plans. Many institutions, however, have begun using heterogeneous plans. Is it possible to satisfy the requirements of such a protocol while achieving the superior accuracy of heterogeneous treatment planning? At the University of Texas M. D. Anderson Cancer Center, we currently use conformal treatment planning with heterogeneities for thoracic cancers. This paper describes a procedure that has been developed to satisfy the requirements of a homogeneous protocol, such as RTOG 98-01 (A Phase III Study of Amifostine mucosal protection), while maintaining accuracy in treatment planning.
authors.affiliation: Radiation Physics, The University of Texas, MD . Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Chris
authors.initials: C
authors.lastname: Brooks
authors.forename: George
authors.initials: G
authors.lastname: Starkschall
authors.forename: Robin
authors.initials: R
authors.lastname: Famiglietti
authors.forename: James
authors.initials: J
authors.lastname: Cox
authors.forename: Steven
authors.initials: S
authors.lastname: Frank
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Komaki
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Liao
authors.forename: Craig
authors.initials: C
authors.lastname: Stevens
authors.forename: Kenneth
authors.initials: K
authors.lastname: Forster
mesh_terms: D004999:Amifostine / Q000627:therapeutic use; D002985:Clinical Protocols; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D010347:Patient Care Planning; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D011882:Radiotherapy, High-Energy
chemical_list: D011837:Radiation-Protective Agents; D004999:Amifostine