title: Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
abstract: Recent preliminary data suggest that vaccination with Alzheimer A beta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-A beta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated A beta 1-42. Immunized monkeys developed anti-A beta titers exceeding 1:1000, and their plasma A beta levels were 5- to 10-fold higher than the plasma A beta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta.
authors.affiliation: Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA. samgandy@earthlink.net
authors.forename: Sam
authors.initials: S
authors.lastname: Gandy
authors.forename: Ron B
authors.initials: RB
authors.lastname: DeMattos
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Lemere
authors.forename: Frank L
authors.initials: FL
authors.lastname: Heppner
authors.forename: Jodi
authors.initials: J
authors.lastname: Leverone
authors.forename: Adriano
authors.initials: A
authors.lastname: Aguzzi
authors.forename: William B
authors.initials: WB
authors.lastname: Ershler
authors.forename: Jinlu
authors.initials: J
authors.lastname: Dai
authors.forename: Paul
authors.initials: P
authors.lastname: Fraser
authors.forename: Peter St George
authors.initials: PS
authors.lastname: Hyslop
authors.forename: David M
authors.initials: DM
authors.lastname: Holtzman
authors.forename: Lary C
authors.initials: LC
authors.lastname: Walker
authors.forename: Evan T
authors.initials: ET
authors.lastname: Keller
mesh_terms: D016229:Amyloid beta-Peptides / Q000276:immunology* / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation; D004195:Disease Models, Animal; D005260:Female; D007114:Immunization / Q000662:veterinary; D008253:Macaca mulatta; D014612:Vaccines / Q000276:immunology*
chemical_list: D016229:Amyloid beta-Peptides; D014612:Vaccines