A simple approach to sensor discovery and fabrication on self-assembled monolayers on glass.
Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (microCP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.
Basabe-Desmonts
Lourdes
L
Department of Supramolecular Chemistry and Technology, Applied Optics Group, Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Beld
Joris
J
Zimmerman
Rebecca S
RS
Hernando
Jordi
J
Mela
Petra
P
García Parajó
María F
MF
van Hulst
Niek F
NF
van den Berg
Albert
A
Reinhoudt
David N
DN
Crego-Calama
Mercedes
M