title: Bacterial genomes pave the way to novel vaccines.
abstract: The availability of complete genome sequences of pathogens has dramatically changed the scope for developing improved and novel vaccines by increasing the speed of target identification. Genomics-based technologies have many advantages, compared to conventional approaches, which are time-consuming and usually identify only abundant antigens that are expressible under in vitro culture conditions. This review focuses on recent reports of genomics-based strategies that can be applied to most pathogens and that exploit genome sequence information in alliance with adjunct technologies, including bioinformatics, expression analyses, random mutagenesis or protein/peptide-based selection methods. Despite the caveats that are associated with the individual approaches, these technologies have already made major contributions to the identification and selection of novel vaccine candidates to combat bacterial infections.
authors.affiliation: Intercell AG, Campus Vienna Biocenter 6, A-1030 Vienna, Austria.
authors.forename: Andreas
authors.initials: A
authors.lastname: Meinke
authors.forename: Tamas
authors.initials: T
authors.lastname: Henics
authors.forename: Eszter
authors.initials: E
authors.lastname: Nagy
mesh_terms: D001424:Bacterial Infections / Q000517:prevention & control; D001428:Bacterial Vaccines; D019295:Computational Biology; D015195:Drug Design; D020869:Gene Expression Profiling; D016680:Genome, Bacterial; D023281:Genomics; D006801:Humans; D016296:Mutagenesis; D014158:Transcription, Genetic
chemical_list: D001428:Bacterial Vaccines