title: Biological performance of uncoated and octacalcium phosphate-coated Ti6Al4V.
abstract: The in vivo behavior of a porous Ti6Al4V material that was produced by a positive replica technique, with and without an octacalcium phosphate (OCP) coating, has been studied both in the back muscle and femur of goats. Macro- and microporous biphasic calcium phosphate (BCP) ceramic, known to be both osteoconductive and able to induce ectopic bone formation, was used for comparison purpose. The three groups of materials (Ti6Al4V, OCP Ti6Al4V and BCP) were implanted transcortically and intramuscularly for 6 and 12 weeks in 10 adult Dutch milk goats in order to study their osteointegration and osteoinductive potential. In femoral defects, both OCP Ti6Al4V and BCP were performing better than the uncoated Ti6Al4V, at both time points. BCP showed a higher bone amount than OCP Ti6Al4V after 6 weeks of implantation, while after 12 weeks, this difference was no longer significant. Ectopic bone formation was found in both OCP Ti6Al4V and BCP implants after 6 and 12 weeks. The quantity of ectopically formed bone was limited as was the amount of animals in which the bone was observed. Ectopic bone formation was not found in uncoated titanium alloy implants, suggesting that the presence of calcium phosphate (CaP) is important for bone induction. This study showed that CaPs in the form of coating on metal implants or in the form of bulk ceramic have a significantly positive effect on the bone healing process.
authors.affiliation: Institute of Biomedical Technology, Department Bilthoven, Twente University, Professor Bronkhorstlaan 10-D, Bilthoven 3720 MB, Netherlands. p.habibovic@tnw.utwente.nl
authors.forename: Pamela
authors.initials: P
authors.lastname: Habibovic
authors.forename: Jiaping
authors.initials: J
authors.lastname: Li
authors.forename: Chantal M
authors.initials: CM
authors.lastname: van der Valk
authors.forename: Gert
authors.initials: G
authors.lastname: Meijer
authors.forename: Pierre
authors.initials: P
authors.lastname: Layrolle
authors.forename: Clemens A
authors.initials: CA
authors.lastname: van Blitterswijk
authors.forename: Klaas
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000497:Alloys; D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D005264:Femoral Fractures / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D017102:Fracture Healing / Q000502:physiology*; D006041:Goats; D020007:Implants, Experimental; D008422:Materials Testing; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D016062:Porosity; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C031462:titanium alloy (TiAl6V4); C022045:octacalcium phosphate; D014025:Titanium