Multidrug-resistant strains of Salmonella enterica Typhimurium, United States, 1997-1998.
To evaluate multidrug-resistant strains of Salmonella enterica serotype Typhimurium, including definitive type 104 (DT104) in the United States, we reviewed data from the National Antimicrobial Resistance Monitoring System (NARMS). In 1997 to 1998, 703 (25%) of 2,767 serotyped Salmonella isolates received at NARMS were S. Typhimurium; antimicrobial susceptibility testing and phage typing were completed for 697. Fifty-eight percent (402) were resistant to > or = 1 antimicrobial agent. Three multidrug-resistant (> or = 5 drugs) strains accounted for (74%) 296 of all resistant isolates. Ceftriaxone resistance was present in 8 (3%), and nalidixic acid resistance in 4 (1%), of these multidrug-resistant strains. By phage typing, 259 (37%) of S. Typhimurium isolates were DT104, 209 (30%) were of undefined type and 103 (15%) were untypable. Fifty percent (202) of resistant (> or = 1 drug) isolates were DT104. Multidrug-resistant S. Typhimurium isolates, particularly DT104, account for a substantial proportion of S. Typhimurium isolates; ceftriaxone resistance is exhibited by some of these strains.
Rabatsky-Ehr
Therese
T
Yale University School of Medicine, New Haven, Connecticut, USA. Therese.Rabatsky-Ehr@po.state.ct.us
Whichard
Jean
J
Rossiter
Shannon
S
Holland
Ben
B
Stamey
Karen
K
Headrick
Marcia L
ML
Barrett
Timothy J
TJ
Angulo
Frederick J
FJ
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001434:Bacteriophage Typing; D002648:Child; D002675:Child, Preschool; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D011159:Population Surveillance; D015995:Prevalence; D012480:Salmonella Infections / Q000453:epidemiology* / Q000382:microbiology; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects*; D012703:Serotyping; D014481:United States / Q000453:epidemiology
D000900:Anti-Bacterial Agents