Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats - an effect of tranexamic acid.
We clarified the role of fibrinolysis in tissue-factor (TF)-induced rat disseminated intravascular coagulation (DIC) using tranexamic acid (TA). TA suppressed the elevation in D-dimer levels normally observed following TF-induced DIC, and an increase in organ dysfunction was seen. Enhanced fibrinolysis plays an important role in preventing the development of organ failure in TF-induced DIC.
Asakura
Hidesaku
H
Sano
Yoko
Y
Yamazaki
Masahide
M
Morishita
Eriko
E
Miyamoto
Ken-ichi
K
Nakao
Shinji
S
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy*; D005342:Fibrinolysis / Q000502:physiology*; D006487:Hemostasis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013925:Thromboplastin / Q000494:pharmacology*; D014148:Tranexamic Acid / Q000494:pharmacology*
D014148:Tranexamic Acid; D013925:Thromboplastin