Effect of factor VIIIc levels in pediatric stroke patients.
Twenty consecutive patients with ischemic stroke confirmed by magnetic resonance imaging and 40 healthy age-matched controls were enrolled in the study. Thirteen of the patients had an underlying disease and/or risk factors. Infection was the most common underlying factor (4 patients). Four patients had heterozygote FVL and 3 patients showed heterozygosity for PT 20210A. A weak positive association between FV1691A and high FVIIIc levels (r = -.110) was determined. Comparison of the prevalence of high FVIIIc levels in patients and healthy subjects with and without FVL/PT 20210 indicated that high FVIII levels are an independent risk factor.
Cangöz
Emel
E
Ankara University, School of Medicine, Department of Pediatrics, Ankara, Turkey.
Deda
Gülhis
G
Akar
Nejat
N
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005165:Factor V; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections / Q000150:complications; D008297:Male; D016017:Odds Ratio; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000209:etiology* / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005169:Factor VIII