[The liver and the nervous system].
This review considers the liver adrenergic and cholinergic innervation in connection with its trophic function. The attempt was made to analyse mechanisms of nervous regulation of liver metabolism and to estimate the role of co-transmitters in metabolic functions of the peptidergic fibers. Liver and portal vein afferent sensors for amino acids, glucose, insulin, glucagon, leptin and osmosensors were described. These sensors detect the liver metabolic signals and transmit them by vagal hepatic afferents to the network of hypothalamic and cortical structures.
Parfenova
N S
NS
Institute of Experimental Medicine, Russian Academy of Medical Sciences, Academician Pavlov Street., 12, St-Petersburg, 197376, Russia.
D000109:Acetylcholine / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D004525:Efferent Pathways / Q000502:physiology; D004837:Epinephrine / Q000502:physiology; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000294:innervation* / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010275:Parasympathetic Nervous System / Q000502:physiology; D011169:Portal Vein / Q000294:innervation; D013564:Sympathetic Nervous System / Q000502:physiology
D018377:Neurotransmitter Agents; D000109:Acetylcholine; D004837:Epinephrine