title: Early use of artificial sensibility in hand transplantation.
abstract: Hands were transplanted from brain-dead donors for the treatment of two male unilateral amputees, aged 35 years and 32 years, involved in the Italian Hand Transplantation Programme. Each had lost his right dominant hand, in a farming accident and an explosion, respectively. In one case artificial sensibility was applied postoperatively using a Sensor Glove that transformed vibrotactile stimuli induced by touch, to stereophonic vibroacoustic stimuli perceived through earphones. The principle is based on the brain's capacity for multimodal plasticity, implying that deprivation of one sense (somatosensory) can be compensated for by another sense (auditory). Functional magnetic resonance images (fMRI) taken at regular intervals showed that cortical remodelling of the transplanted hand within the sensory-motor maps occurred early in the patient who used the artificial sensibility regimen compared with the one who did not. We conclude that postoperative use of a device using hearing as a substitution for sensation in hand transplantation may have considerable potential value for speeding up cortical integration of a transplanted hand.
authors.affiliation: Hand Surgery and Reconstructive Microsurgery Unit, San Gerardo Hospital, University of Milan-Bicocca, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Lanzetta
authors.forename: Daniela
authors.initials: D
authors.lastname: Perani
authors.forename: Davide
authors.initials: D
authors.lastname: Anchisi
authors.forename: Birgitta
authors.initials: B
authors.lastname: Rosén
authors.forename: Massimo
authors.initials: M
authors.lastname: Danna
authors.forename: Paola
authors.initials: P
authors.lastname: Scifo
authors.forename: Ferruccio
authors.initials: F
authors.lastname: Fazio
authors.forename: Göran
authors.initials: G
authors.lastname: Lundborg
mesh_terms: D000328:Adult; D000673:Amputation, Traumatic / Q000601:surgery; D001926:Brain Death; D006225:Hand / Q000294:innervation*; D063987:Hand Transplantation; D006801:Humans; D019520:Living Donors; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000502:physiology; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012678:Sensation Disorders / Q000534:rehabilitation*; D012815:Signal Processing, Computer-Assisted; D013499:Surface Properties; D014110:Touch