Serum IL-8 as a possible marker for determining the status of Helicobacter pylori infection in patients with untreated and treated peptic ulcer.
Failure to eradicate Helicobacter pylori can lead to peptic ulcer recurrence and gastric malignancy. Therefore, the objective of this study was to develop a noninvasive method for determining whether H. pylori infection was eradicated with antibiotic-based triple therapy. A total of 17 patients with duodenal ulcer (DU) and 17 with gastric ulcer (GU) were evaluated both before and after treatment. Outcomes included serum levels of interleukin-8 (IL-8), pepsinogen I, and gastrin, and the Wilcoxon signed rank test was used to test significance. Changes in these parameters were also correlated with disease status. In those patients where both GU and DU healing occurred as a result of treatment, most showed an increase in serum IL-8 and a decrease in serum pepsinogen. Serum gastrin levels were not significantly changed in either group. Posttreatment increases in serum IL-8 were seen in 15 of 17 (88%) recovered DU patients and 14 of 17 (82%) recovered GU patients (P<.05 for each). Posttreatment decreases in pepsinogen I were found in 15 of 17 DU and 15 of 17 GU patients (P<.05 for each). These preliminary findings suggest that an increase in serum IL-8 and possibly a decrease in pepsinogen I may be useful in identifying the successful eradication of H. pylori infection in patients with peptic ulcer treated with antibiotics. A more systematic analysis of these putative diagnostic markers is now warranted.
Cheng
Ken-Sheng
KS
Department of Internal Medicine, College of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Tang
Hui-Ling
HL
Chou
Fu-Tsan
FT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D017291:Clarithromycin / Q000008:administration & dosage; D005260:Female; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage; D020116:Pepsinogen A / Q000097:blood; D010437:Peptic Ulcer / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D011237:Predictive Value of Tests
D015415:Biomarkers; D005755:Gastrins; D016209:Interleukin-8; D000658:Amoxicillin; D020116:Pepsinogen A; D017291:Clarithromycin; D009853:Omeprazole