Immunohistochemical study of serotonin in lesions of psoriasis.
OBJECTIVE
To study the role of serotonin in the pathogenesis of psoriasis.


METHODS
Immunohistochemical techniques were used to study the expression of serotonin in the lesions of patients with psoriasis.


RESULTS
Expression of serotonin was significantly stronger in the prickle cells, sweat gland cells, sebaceous gland cells, and hair roots of the lesions in the progressive stage of psoriasis than in the static stage. There was no difference in serotonin expression between the vulgaris type and the pustular type. No expression of serotonin occurred in the specimens of normal skin.


CONCLUSIONS
Serotonin probably plays an important role in the pathogenesis and activity of psoriasis.
Huang
Jianguo
J
Department of Dermatology, People's Hospital of Xiangxi Autonomous Prefecture (the First Affiliated Hospital of Ji-shou University), Ji-shou City, Hunan Province, China. huangjianguo11@sina.com
Li
Guiming
G
Xiang
Jihu
J
Yin
Daochun
D
Chi
Ridong
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology*; D012701:Serotonin / Q000097:blood / Q000378:metabolism*
D012701:Serotonin