title: Lessons from two "triple nuke" failures (new training module).
abstract: A CME (continuing medical education) module for physicians explains the problem with two antiretroviral regimens that failed last year. Several possible causes for the failure had been proposed. Now it appears that the problem was too low a genetic barrier to HIV developing certain resistance mutations.
mesh_terms: D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*
chemical_list: D018894:Reverse Transcriptase Inhibitors