title: Relationship of predialytic intact parathyroid hormone on secondary hyperparathyroidism in chronic maintenance haemodialysis patients.
abstract: RESULTS
  In order to clarify the predialytic factors influencing the onset of secondary hyperparathyroidism (SHPT) in patients on chronic maintenance haemodialysis, the time-course changes of serum levels of intact-PTH (i-PTH) during haemodialysis for 5 years were investigated. The subjects were 69 non-diabetic patients who had a serum aluminium level of less than 1.85 nmol/L at the end of observation. Patients were divided into two groups based on i-PTH levels obtained at the start of dialysis; the high group (H group) consisted of patients whose i-PTH levels were more than 22.00 pmol/L, the low group (L group) had levels less than 22.00 pmol/L. In the H group, i-PTH was 41.46 +/- 2.87 pmol/L at the start of dialysis (vs L group, P < 0.0001) and 15.82 +/- 2.85 pmol/L after haemodialysis initiation. In the L group, i-PTH levels did not significantly change and was 11.69 +/- 2.50 pmol/L 12 months after the start of dialysis (at the 12th month). However, at the 60th month, the i-PTH level was 33.24 +/- 5.30 pmol/L in the H group, and 9.85 +/- 2.13 pmol/L in the L group (P < 0.005).
  
  
  CONCLUSIONS
  It is suggested that control of i-PTH levels in the predialytic period may be important to suppress SHPT throughout haemodialysis.
authors.affiliation: Division of Nephrology and Rheumatology, Department of Internal Medicine, Fukuoka University School of Medicine and Kawanami Hospital Kidney Center, Fukuoka, Japan. etohs@minf.med.fukuoka-u.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Etoh
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Murata
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Miyahara
authors.forename: Atunori
authors.initials: A
authors.lastname: Ishimura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Abe
authors.forename: Ritsuya
authors.initials: R
authors.lastname: Noda
authors.forename: Satoru
authors.initials: S
authors.lastname: Ogahara
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kaneoka
authors.forename: Takao
authors.initials: T
authors.lastname: Saito
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone