Low-dose aspirin in a short regimen as standard treatment in in vitro fertilization: a randomized, prospective study.
OBJECTIVE
To determine if treatment with low-dose aspirin in a short regimen improves the outcome in a nonselected IVF population as compared with no treatment.


METHODS
Prospective, randomized study where IVF patients were given aspirin or received no treatment.


METHODS
IVF clinic.


METHODS
The study included 1380 consecutive IVF cycles.


METHODS
Women undergoing IVF were randomly assigned to treatment with aspirin 75 mg daily from the day of embryo transfer (ET) until pregnancy test or no treatment in an open study.


METHODS
Birth rate per ET.


RESULTS
Background characteristics were similar in the two groups studied except for a minor difference in number of embryos transferred (2.1 vs. 2.0). Birth rate was 27.2% in the aspirin group as compared with 23.2% in the nontreated group, giving an odds ratio, adjusted for number of embryos transferred, of 1.2 (95% confidence interval, 1.0-1.6).


CONCLUSIONS
The increased birth rate with aspirin compared with no treatment was significant. Given the importance of every birth in IVF, especially when taking into account the limited number of IVF cycles that are normally performed in an individual woman, any treatment to improve birth rate is important.
Waldenström
Urban
U
In Vitro Fertilization Unit, Falun Hospital, Falun, Sweden. waldenstrom@ltdalarna.se
Hellberg
Dan
D
Nilsson
Staffan
S
D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D001723:Birth Rate; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D016017:Odds Ratio; D011247:Pregnancy; D016896:Treatment Outcome
D000925:Anticoagulants; D001241:Aspirin