title: Genetic defects, ionic currents and electrocardiographic alterations.
abstract: Most experimental data on the kinetic properties of cardiac ion channels and their modification by genetic defects have been obtained in expression systems (e.g., Xenopus oocyte), away from the cellular environment where these channels function to generate the cardiac action potential. In this article, we describe the use of computational biology (computer simulations) in integrating such information on single ion channels into models of the functioning cardiac cell. We use this approach to mechanistically relate molecular processes to whole-cell electrophysiological function and its manifestation in electrocardiographic waveforms. Examples are provided from the congenital long QT syndrome and the Brugada syndrome.
authors.affiliation: Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, 509 Wickenden Building, Cleveland, OH 44106-7207, USA. yxr@po.cwru.edu
authors.forename: Yoram
authors.initials: Y
authors.lastname: Rudy
mesh_terms: D000200:Action Potentials; D000818:Animals; D003198:Computer Simulation; D004562:Electrocardiography; D006352:Heart Ventricles / Q000166:cytology; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000502:physiology*; D008133:Long QT Syndrome / Q000235:genetics / Q000503:physiopathology; D008954:Models, Biological; D009154:Mutation; D032383:Myocytes, Cardiac / Q000502:physiology*; D016276:Ventricular Function
chemical_list: D007473:Ion Channels