title: [Early loss of teeth after treatment for childhood leukemia].
abstract: BACKGROUND
  Only few reports of effects of radiotherapy in childhood on the dental apparatus are available in the literature. The basis for early loss of teeth appears to be a reduction of the root surface area after radiation exposure. These effects in the periodontium are a consequence of combined radiochemotherapy usually applied for treatment of childhood neoplasia. Chemotherapy alone also results in changes of periodontal development.
  
  
  METHODS
  A 33-year-old patient is reported, who, at the age of 11 years, received high-dose chemotherapy and radiotherapy of neuroaxis and cranium for acute lymphatic leukemia with relapse. The patient consulted the Implant Section of the Department of Oral and Maxillofacial Surgery because of severe dental changes and tooth loss despite adequate dental care and oral hygiene. Radiation doses given to the superior maxilla and mandible at the age of 11 were estimated to be in the range of 8-25 Gy.
  
  
  CONCLUSIONS
  Intense, life-long dental care and follow-up of patients cured from malignant disease in childhood must hence be postulated in order to minimize dental treatment sequelae by supportive measures, but also to initiate timely adequate dental and prosthetic management.
authors.affiliation: Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Medizinische Fakultät der Technischen Universität Dresden, Dresden. thomas.herrmann@mailbox.tu-dresden.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Herrmann
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dörr
authors.forename: Susanne
authors.initials: S
authors.lastname: Koy
authors.forename: Aquina
authors.initials: A
authors.lastname: Lesche
authors.forename: Dietmar
authors.initials: D
authors.lastname: Lehmann
mesh_terms: D000328:Adult; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008334:Mandible / Q000528:radiation effects; D008437:Maxilla / Q000528:radiation effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012888:Skull Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000517:prevention & control; D016388:Tooth Loss / Q000209:etiology