Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.
A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano[3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM.
Ogawa
Akitsu
A
Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan.
Murakami
Chikako
C
Kamisuki
Shinji
S
Kuriyama
Isoko
I
Yoshida
Hiromi
H
Sugawara
Fumio
F
Mizushina
Yoshiyuki
Y
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056890:Eukaryota / Q000382:microbiology*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D008297:Male; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D002839:Chromans; C495736:pseudodeflectusin; D005978:Glutathione