title: Alveolar adenoma of the lung: a clinicopathologic, immunohistochemical, and molecular study of an unusual case.
abstract: We describe an alveolar adenoma of the lung with 3 previously unreported findings, which expand both the clinical and the morphologic spectrum of this rare tumor: presentation as a cystic nodule, foci of mature adipocytes, and S-100 positivity of the mesenchymal cells. Furthermore, using a laser capture microdissection technique under microscope visualization, we analyzed multiple chromosomal loci in both the epithelial and mesenchymal components of the lesion, showing microsatellite alterations and loss of heterozygosity in the former but not in the latter.
authors.affiliation: Department of Pathology, S. Maria Nuova Hospital, Reggio Emilia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazza
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Paci
authors.forename: Loredana
authors.initials: L
authors.lastname: De Marco
authors.forename: Guido
authors.initials: G
authors.lastname: Leporati
authors.forename: Giuliana
authors.initials: G
authors.lastname: Sartori
authors.forename: Nazzarena
authors.initials: N
authors.lastname: Bigiani
authors.forename: Giulio
authors.initials: G
authors.lastname: Rossi
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D017667:Adipocytes / Q000378:metabolism / Q000473:pathology; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis; D006801:Humans; D007834:Lasers; D019656:Loss of Heterozygosity / Q000235:genetics; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D042282:Microdissection / Q000295:instrumentation; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D004273:DNA, Neoplasm; D009418:S100 Proteins