Intravenous busulfan as preparative regimen in pediatric patients receiving hematopoietic stem cell transplantation: the preliminary experience in Taiwan.
BACKGROUND
Some studies have proved that intravenous busulfan with cyclophosphamide (used as a component of conditioning regimens for hematopoietic stem cell transplantation) is safer and has fewer complication than oral busulfan in adults, whereas the same proof in pediatric patients is only limited, with no reported data so far from Asian countries. In this study, we aimed to evaluate the efficacy and complications of IV busulfan in pediatric patients.


METHODS
Three pediatric patients with acute myeloid leukemia were treated by intravenous busulfan combined with cyclophosphamide to compare retrospectively with the treatment with oral busulfan plus intravenous cyclophosphamide in another three pediatric cases having transplantation in the same institute.


RESULTS
The results showed that the intravenous busulfan-based regimen had better compliance and less adverse effects including mucositis, hepatic toxicity, transplant-related hepatic veno-occlusive disease, and acute graft-versus-host disease than oral busulfan-based treatment.


CONCLUSIONS
The conditioning regimen of intravenous busulfan combined with cyclophosphamide is an acceptable alternative for pediatric patients with hematological malignancies in Taiwan. The long-term benefit and adverse effects of intravenous busulfan should be further explored.
Lee
Ming-Yang
MY
Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, ROC.
Chiou
Tzeon-Jye
TJ
Bai
Li-Yuan
LY
Hsiao
Liang-Tsai
LT
Hung
Giun-Yi
GY
Chang
Chia-Yau
CY
Chen
Po-Min
PM
D000293:Adolescent; D002066:Busulfan / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D012189:Retrospective Studies; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
D002066:Busulfan