title: Management of an ABO-incompatible lung transplant.
abstract: A 24-year-old woman with cystic fibrosis underwent bilateral sequential lung transplantation and unintentionally received an ABO incompatible graft (blood type A(1) graft into a type O recipient). The recipient had a high titer of IgG anti-A antibody (256 by the indirect antiglobulin test). Emergency treatment included antibody removal by plasmapheresis and additional immunosuppression with mycophenolate, rabbit antithymocyte globulin and polyspecific intravenous immunoglobulin. Subsequently, immunoadsorption and the anti-CD20 antibody rituximab were used to remove anti-A antibody and inhibit its resynthesis. Early graft function was good; one episode of rejection at Day 46 responded promptly to treatment with methylprednisolone. Subsequently, graft function continued to improve and anti-A antibody titers remained low. No infectious or other complications were encountered. The treatment regimen that we adopted may prove useful in other cases of unplanned ABO-incompatible organ transplants. The successful outcome suggests that planned ABO-incompatible lung transplants may be possible.
authors.affiliation: Transplant Unit, Harefield Hospital, Royal Brompton and Harefield NHS Trust, Harefield, Middlesex, UK.
authors.forename: Nicholas R
authors.initials: NR
authors.lastname: Banner
authors.forename: Marlene L
authors.initials: ML
authors.lastname: Rose
authors.forename: David
authors.initials: D
authors.lastname: Cummins
authors.forename: Mahes
authors.initials: M
authors.lastname: de Silva
authors.forename: Alison
authors.initials: A
authors.lastname: Pottle
authors.forename: Haifa
authors.initials: H
authors.lastname: Lyster
authors.forename: Peter
authors.initials: P
authors.lastname: Doyle
authors.forename: Martin
authors.initials: M
authors.lastname: Carby
authors.forename: Asghar
authors.initials: A
authors.lastname: Khaghani
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D018951:Antigens, CD20 / Q000096:biosynthesis; D001787:Blood Group Incompatibility; D003550:Cystic Fibrosis / Q000628:therapy; D005260:Female; D006084:Graft Rejection; D016027:Heart Transplantation / Q000379:methods*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007163:Immunosorbent Techniques; D007166:Immunosuppressive Agents; D016040:Lung Transplantation / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System; D018951:Antigens, CD20; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents