[Investigation on release model of insoluble drug in hydroxypropyl methycellulose matrix tablets].
To investigate the release model of insoluble drug carbamazepine (CBM) based on HPMC matrix tablets.



CBM release profile from matrices and HPMC erosion rate were determined.



The mathematical model by matrix erosion rate and drug release from HPMC K15M were established for the fractional HPMC and CBM released as M(P(t))/M(P(infinity))=-[0.8095ln((t))+1.2775]Meq((-0.0622t-0.305)) and M(d(t))/M(d(infinity))=-[0.1891t-0.1294]Meq(-0.9326). In comparison with the data of HPMC K4M matrix erosion and CBM release from HPMC K4M matrices, theoretical value agreed well with experimental data.



The two mathematical models can be satisfactorily applied to insoluble drug release, which is governed by matrix erosion.
Ma
Xiao-wei
XW
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, China.
Yuan
Jing-qun
JQ
Liang
Wen-quan
WQ
D002220:Carbamazepine / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000008:administration & dosage* / Q000031:analogs & derivatives; D008962:Models, Theoretical; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D013607:Tablets; D002220:Carbamazepine; D065347:Hypromellose Derivatives; D008747:Methylcellulose