Synthesis and application in asymmetric C-C bond formation of solution phase ligand libraries of monodentate phosphoramidites.
A library of 96 unique monodentate phosphoramidite ligands has been synthesized in solution and used in the asymmetric conjugate addition of potassium vinyltrifluoroborate to enones resulting in up to 88% ee.
Duursma
Ate
A
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Lefort
Laurent
L
Boogers
Jeroen A F
JA
de Vries
André H M
AH
de Vries
Johannes G
JG
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL