[Pharmacokinetics of mifepristone and kinetics of chorionic gonadotropin beta-subunit (beta-HCG) and progesterone in plasma of pregnant women during pharmacological interruption of early pregnancy].
Reliable correlations between the parameters of mifepriston pharmacokinetics describing the rate of drug elimination from the blood plasma and the levels of beta-human chorionic gonadotropin (beta-HCG) and progesterone reflecting the state of gestation in females have been established fore the first time. According to these relationships, the half elimination time, the mean retention time, and the plasma clearance of mifepriston can be considered as predictors of the clinical efficacy of this drug for the early pregnancy interruption.
Kulakov
V I
VI
Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences, akad. Oparina ul. 4, Moscow, 117815 Russia.
Zherdev
D V
DV
Sariev
A K
AK
Kolyvanov
G B
GB
Volkov
N I
NI
Kolod'ko
V G
VG
Zherdev
V P
VP
D000021:Abortifacient Agents, Steroidal / Q000097:blood / Q000493:pharmacokinetics*; D000028:Abortion, Induced / Q000379:methods*; D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000097:blood / Q000493:pharmacokinetics*; D010949:Plasma; D011247:Pregnancy / Q000097:blood*
D000021:Abortifacient Agents, Steroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D015735:Mifepristone