Corticosteroids, depression and the role of serotonin.
Patients frequently use medications simultaneously for different complaints, without being aware of the interactions these products may have. An example of this is the simultaneous use of corticosteroids and medications for depression, defiant or aggressive behaviour. Research has also indicated that corticosteroids lower serotonin levels. However, lowered serotonin levels may result in depression, aggression and other psychological conditions. These secondary complaints, caused by the corticosteroids and other products that lower serotonin levels, may then be treated with selective serotonin reuptake inhibitors (SSRIs) or psycho-stimulants (that are known to indirectly increase serotonin levels). The current research takes a look at lowered serotonin levels when using corticosteroids, as well as the interactions with SSRIs and psycho-stimulants. Furthermore, evidence is presented to prove the hypothesis that some individuals with asthma (e.g. children using systemic corticosteroids that lower serotonin levels) might present with symptoms of depression, attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder and even conduct disorder; and that treating these secondary complaints with SSRIs and psycho-stimulants will result in the upregulating of serotonin levels, and that, in turn, will trigger asthma.
Pretorius
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Department of Anatomy, University of Pretoria, South Africa. resia.pretorius@up.ac.za
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects* / Q000502:physiology; D003864:Depression, Chemical; D003866:Depressive Disorder / Q000139:chemically induced* / Q000188:drug therapy / Q000378:metabolism; D015536:Down-Regulation / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects
D000305:Adrenal Cortex Hormones; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors