Can oral cholera vaccination play a role in controlling a cholera outbreak?
Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% CI: 71.9-84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures.
Calain
Philippe
P
WHO Western Pacific Regional Office, Manila, Philippines.
Chaine
Jean-Paul
JP
Johnson
Eliaser
E
Hawley
Mary-Lou
ML
O'Leary
Michael J
MJ
Oshitani
Hitoshi
H
Chaignat
Claire-Lise
CL
D000284:Administration, Oral; D002771:Cholera / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D022121:Cholera Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004196:Disease Outbreaks / Q000191:economics / Q000517:prevention & control*; D006801:Humans; D014611:Vaccination
D022121:Cholera Vaccines