title: Dapsone hypersensitivity syndrome masquerading as a viral exanthem: three cases and a mini-review.
abstract: BACKGROUND
  We report 3 cases of dapsone hypersensitivity syndrome due to anti-malarial chemoprophylactic treatment with maloprim, in military servicemen, presenting like a viral exanthem.
  
  
  METHODS
  Three male military recruits presented with fever and rash, 6 to 8 weeks after commencing on weekly doses of maloprim.
  
  
  METHODS
  A course of topical and systemic corticosteroids and oral antihistamines were started.
  
  
  RESULTS
  All cases showed gradual resolution of fever, rash and eventual normalisation of liver function test.
  
  
  CONCLUSIONS
  A high index of suspicion was required before this uncommon syndrome can be recognised. Early institution of corticosteroid therapy and discontinuation of maloprim are the mainstays of treatment.
authors.affiliation: Department of Medicine, Changi General Hospital, Singapore.
authors.forename: A K H
authors.initials: AK
authors.lastname: Tee
authors.forename: H M L
authors.initials: HM
authors.lastname: Oh
authors.forename: I Y J
authors.initials: IY
authors.lastname: Wee
authors.forename: B P
authors.initials: BP
authors.lastname: Khoo
authors.forename: W T
authors.initials: WT
authors.lastname: Poh
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D003622:Dapsone / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004338:Drug Combinations; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005076:Exanthema / Q000175:diagnosis; D006801:Humans; D008297:Male; D011739:Pyrimethamine / Q000009:adverse effects*; D017193:Skin Diseases, Viral / Q000175:diagnosis
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001678:Maloprim; D003622:Dapsone; D011739:Pyrimethamine