Change in contents of biologically active sphingolipids modulating cell growth and survival in hepatoma 27 compared to rat liver.
The contents of bioactive sphingolipids (sphingomyelin, ceramide, glucosyl- and lactosylceramides, gangliosides) were studied in rat hepatoma 27 and rat liver. The amounts of sphingomyelin, ceramide, and glucosyl- and lactosylceramides were about twofold and that of gangliosides was about 3.5-fold increased in the tumor compared to normal tissue. Since sphingomyelin promotes angiogenesis, glucosyl- and lactosylceramides stimulate proliferation, gangliosides inhibit apoptosis, but ceramides suppress proliferation and stimulate apoptosis, it is obvious that the balance of these effectors in hepatoma 27 moves with the tumor growth.
Kandyba
A G
AG
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia.
Kobliakov
V A
VA
Somova
O G
OG
Dyatlovitskaya
E V
EV
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D002518:Ceramides / Q000378:metabolism; D002855:Chromatography, Thin Layer; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D013107:Sphingolipids / Q000378:metabolism*; D013109:Sphingomyelins / Q000378:metabolism
D002518:Ceramides; D013107:Sphingolipids; D013109:Sphingomyelins