title: Postprandial increase in plasma concentrations of remnant-like particles: an independent risk factor for restenosis after percutaneous coronary intervention.
abstract: Postprandial increase in remnant lipoprotein concentrations has been suggested as an important atherogenic factor. However, the influence of these remnants on the development of restenosis after percutaneous coronary intervention (PCI) remains to be examined. The present study was designed to address this point. In 60 consecutive patients with successful PCI, the influences of possible risk factors on the development of restenosis, including remnant-like particles (RLP) cholesterol (RLP-C) and triglyceride (RLP-TG), were examined. While mean concentrations of RLP-C and RLP-TG were normal in fasting state, postprandial change in RLP-C concentrations was a significant and independent risk factor for restenosis after PCI. The calculated cut-off index (COI) for the change was +64%. When the patients were divided into 2 groups according to this COI, minimal lumen diameter (MLD) and reference coronary diameter were comparable before and immediately after PCI between the high- (COI < 64%) and the low- (COI < 64%) responders. However, follow-up coronary angiography 3 to 6 months after PCI demonstrated that MLD, late loss, and loss index were all worse in the high responders compared with the low responders. These results indicate that post-prandial increase in RLP-C concentrations is an independent risk factor for restenosis after successful PCI, even in patients with normal fasting RLP-C levels.
authors.affiliation: Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Oi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimokawa
authors.forename: Yoji
authors.initials: Y
authors.lastname: Hirakawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Tashiro
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nakaike
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kozai
authors.forename: Keizaburo
authors.initials: K
authors.lastname: Ohzono
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Samon
authors.initials: S
authors.lastname: Koyanagi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Okamatsu
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Tajimi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Takeshita
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D019518:Postprandial Period; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides