title: Electrophilic substitution of dibromoparacyclophane: a route to novel paracyclophane phosphine ligands.
abstract: [reaction: see text] The regioselective functionalization of 4,12-dibromoparacyclophane via electrophilic aromatic substitution is reported for the first time. The functionalization of the paracyclophane backbone allows the development of a new family of paracyclophane-based phosphines (named ParaPhos) that opens the possibility of improved catalyst development and tuning while retaining all the catalysis potential of the PhanePhos family of ligands.
authors.affiliation: Johnson Matthey Catalysis and Chiral Technologies, Unit 28, Cambridge Science Park, Milton Road, Cambridge CB4 0FP, UK.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Dominguez
authors.forename: Antonio
authors.initials: A
authors.lastname: Zanotti-Gerosa
authors.forename: William
authors.initials: W
authors.lastname: Hems
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001952:Bridged-Ring Compounds; D008024:Ligands; D010720:Phosphines; C498380:paracyclophane phosphine