title: Acupuncture suppresses intrastriatal hemorrhage-induced apoptotic neuronal cell death in rats.
abstract: Intracerebral hemorrhage is one of the most devastating types of stroke. In the present study, the effect of acupuncture on intrastriatal hemorrhage-induced neuronal cell death in rats was investigated via Nissl staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, and immunohistochemistry for caspase-3. The present results showed that lesion size and apoptotic neuronal cell death in the striatum were significantly increased following intrastriatal hemorrhage in rats and that acupunctural treatment at the Zusanli acupoint suppressed the hemorrhage-induced increase in lesion size and apoptotic neuronal cell death in the striatum. In the present study, it can be suggested that acupunctural treatment, especially at the Zusanli acupoint, may aid in the recovery following central nervous system sequellae following intracerebral hemorrhage.
authors.affiliation: Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Nam-Hun
authors.initials: NH
authors.lastname: Cho
authors.forename: Jae-Dong
authors.initials: JD
authors.lastname: Lee
authors.forename: Byung-Shik
authors.initials: BS
authors.lastname: Cheong
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Choi
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Chang
authors.forename: Taeck-Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Mal-Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Jongseok
authors.initials: J
authors.lastname: Lee
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D015670:Acupuncture Therapy / Q000379:methods*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000517:prevention & control*; D003342:Corpus Striatum / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley