title: [Gene expression changes of cartilage matrix of condylar cartilage with anterior disc displacement].
abstract: OBJECTIVE
  To study the gene expression changes in extracellular matrix of condylar cartilage following disc anterior displacement of rabbit TMJ.
  
  
  METHODS
  The right sides of 28 joints in 40 rabbits were subjected to surgical operation of disc displacement. The condylar Collagen II and Aggrecan mRNA expression were detected by in situ hybridization.
  
  
  RESULTS
  Collagen II and Aggrecan mRNA mainly expressed in the lower zone of condylar chondrocyte. Aggrecan mRNA decreased faster than collagen II following disc displacement, and adjusted to normal later.
  
  
  CONCLUSIONS
  Anterior disc displacement leads to alteration of extracellurar matrix gene expression in the condylar chondrocyte, which means the start of remodeling.
authors.affiliation: Dept. of Orthodontics, Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Jian-ying
authors.initials: JY
authors.lastname: Feng
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Gu
authors.forename: Takanori
authors.initials: T
authors.lastname: Shibata
mesh_terms: D053674:Aggrecans; D000818:Animals; D016723:Bone Remodeling; D002358:Cartilage, Articular / Q000166:cytology; D019902:Chondrocytes / Q000378:metabolism*; D024043:Collagen Type II / Q000096:biosynthesis* / Q000235:genetics; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D017403:In Situ Hybridization; D037181:Lectins, C-Type; D008297:Male; D008335:Mandibular Condyle / Q000166:cytology / Q000378:metabolism*; D011509:Proteoglycans / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011817:Rabbits; D013704:Temporomandibular Joint / Q000166:cytology / Q000378:metabolism; D019224:Temporomandibular Joint Disc / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000209:etiology / Q000235:genetics* / Q000378:metabolism
chemical_list: D053674:Aggrecans; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D011509:Proteoglycans; D012333:RNA, Messenger