Retroperitoneal malignant peripheral nerve sheath tumor: evaluation with serial FDG-PET.
Retroperitoneal malignant peripheral nerve sheath tumor (MPNST), a rare type of neurogenic tumor, was diagnosed in a 14-year-old girl with a history of neurofibromatosis type 1 (NF1). Immunochemistry demonstrated spindle cells positive for S-100 protein. The patient had multiple tumor recurrences and she was evaluated with serial F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). A tumor in the right iliac wing showed increased FDG uptake on PET. FDG-PET played an important role in therapy planning and subsequent follow up. This case emphasizes the important role FDG-PET could play in the staging, restaging, and posttherapy follow up of MPNST.
Chander
Subhash
S
Department of Radiology, Wayne State University/Detroit Medical Center, Detroit, Michigan,USA. chandler@pol.net
Westphal
Steven M
SM
Zak
Imad T
IT
Bloom
David A
DA
Zingas
Alkis P
AP
Joyrich
Richard N
RN
Littrup
Peter J
PJ
Taub
Jeffrey W
JW
Getzen
Todd M
TM
D000293:Adolescent; D001859:Bone Neoplasms / Q000556:secondary; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018317:Nerve Sheath Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D009456:Neurofibromatosis 1 / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging*; D009418:S100 Proteins / Q000032:analysis; D014055:Tomography, Emission-Computed / Q000379:methods*
D019275:Radiopharmaceuticals; D009418:S100 Proteins; D019788:Fluorodeoxyglucose F18