New insights into imiquimod's mechanisms of action.
Imiquimod, an immune response modifier with potent antiviral and antitumor properties, has been reported to be effective in the treatment of various cutaneous neoplasms. Besides stimulating the production of pro-inflammatory cytokines through Toll-like receptors on the surface of dendritic cells of monocyte-macrophage lineage, novel antiapoptotic mechanisms have been identified.
Martín-García
Rafael F
RF
Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. martinmubarak@aol.com
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000279:Administration, Cutaneous; D000634:Aminoquinolines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D000077271:Imiquimod; D008562:Membrane Glycoproteins / Q000819:agonists / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000819:agonists / Q000378:metabolism; D012878:Skin Neoplasms / Q000188:drug therapy; D051193:Toll-Like Receptors
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D000970:Antineoplastic Agents; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D000077271:Imiquimod