title: Highly enantioselective synthesis of chiral 3-substituted indolines by catalytic asymmetric hydrogenation of indoles.
abstract: [reaction: see text] N-Tosyl 3-substituted indoles were hydrogenated with high enantioselectivities (95-98% ee) by use of a trans-chelating chiral bisphosphine, (S,S)-(R,R)-PhTRAP ligand. The chiral catalyst, which was generated in situ from [Rh(nbd)(2)]SbF(6), PhTRAP, and Cs(2)CO(3), is useful for enantioselectively synthesizing a range of diverse optically active indolines possessing a chiral carbon at the 3-position.
authors.affiliation: Department of Chemistry, Graduate School of Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. rkuwascc@mbox.nc.kyushu-u.ac.jp
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kuwano
authors.forename: Kohei
authors.initials: K
authors.lastname: Kaneda
authors.forename: Takashi
authors.initials: T
authors.lastname: Ito
authors.forename: Koji
authors.initials: K
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ito