Successful spouse pregnancy of male patients with severe aplastic anemia and chronic myelogenous leukemia using spermatozoa banked prior to bone marrow transplantation and using the ICSI procedure: case reports.
OBJECTIVE
To report two cases of successful spouse pregnancies which were conceived with long-term cryopreserved spermatozoa that had been collected prior to the male patients receiving a bone marrow transplant.


METHODS
The first case is the pregnant wife of a 25-year-old man with chronic myelogenous leukemia, whose semen was collected before bone marrow transplant and then cryopreserved, thawed, and then injected into the wife's eggs via ICSI. The second case is a 28-year-old man with severe aplastic anemia who became a father after his wife's eggs were fertilized via ICSI with thawed spermatozoa.


RESULTS
These two cases were achieved pregnancies.


CONCLUSIONS
These cases support research that men with malignancy have the chance of fathering their own genetic children. Therefore, it is important to increase the awareness of clinicians, oncologists, and patients to the new developments in preserving fertility for cancer patients.
Cho
Sung-Won
SW
Genome Research Center for Reproductive Medicine and Infertility of Korea Ministry of Health and Welfare, CHA General Hospital, College of Medicine, Pochon CHA University, 606-5 Yeoksam-dong, Kangnam-ku, Seoul 135-081, Korea.
Lee
Sook-Hwan
SH
Chung
Mi-Kyung
MK
Kim
Hyun-Ah
HA
Chung
Hyung-Min
HM
Lee
Yun-Jung
YJ
Kwon
Hwang
H
Yoon
Tae-Ki
TK
Cha
Kwang-Yul
KY
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications*; D016026:Bone Marrow Transplantation; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012662:Semen Preservation; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000166:cytology*