Effects of gamma-hydroxybutyrate on cerebrospinal fluid lactate and glucose levels after spinal cord trauma.
This study aims to evaluate the effects of gamma-hydroxybutyrate (GHB) after spinal cord trauma (SCT). Twenty rabbits were divided equally into four groups: group I was the sham-operated group, group II suffered from SCT but received no treatment, group III was given a dose of 400 mg/kg of GHB intravenously before SCT and group IV received the same dose after SCT. Cerebrospinal fluid (CSF) samples were obtained 30 min before SCT (T(0)), at 60 (T(1)) and 120 min (T(2)) after SCT. There was a threefold increase in lactate levels from baseline value at T(2) in group II, while statistically significant elevation of the lactate levels were not observed in groups III and IV. Glucose levels at T(1) and T(2) were significantly lower in groups III and IV compared with the control group. The findings of this study demonstrate that GHB can control the increase of CSF lactate and glucose levels following SCT and that this metabolic effect may be associated with neuroprotective physiological changes.
Güney
Onder
O
Department of Neurosurgery, Selçuk University, Meram Medical School, Konya, Turkey.
Bengi Celik
Jale
J
Arazi
Mehmet
M
Erkan Ustun
Mehmet
M
D000759:Adjuvants, Anesthesia / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D005947:Glucose / Q000134:cerebrospinal fluid*; D006339:Heart Rate / Q000187:drug effects; D019344:Lactic Acid / Q000134:cerebrospinal fluid*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011817:Rabbits; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000134:cerebrospinal fluid* / Q000517:prevention & control*; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D019344:Lactic Acid; D012978:Sodium Oxybate; D005947:Glucose