Rhodium(I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines.
[reaction: see text] A novel strategy for the preparation of seven-membered heterocyclic compounds has been realized. Treatment of ene-allene 1 with a catalytic quantity of rhodium biscarbonyl chloride dimer affords the cyclization product 2 in moderate to high yields. The scope and limitations of this new method are currently under investigation, and the results obtained to date are discussed within.
Brummond
Kay M
KM
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. kbrummond@pitt.edu
Chen
Hongfeng
H
Mitasev
Branko
B
Casarez
Anthony D
AD