title: Virological and immunological impact of non-nucleoside reverse transcriptase inhibitor withdrawal in HIV-infected patients with multiple treatment failures.
abstract: No significant changes in viral load and CD4 cell count were observed 2-4 weeks after the withdrawal of non-nucleoside reverse transcriptase inhibitors (NNRTI) from the current therapy of patients exhibiting resistance mutations to this class of drugs. The data suggest that in the presence of specific resistance mutations NNRTIexert no residual antiretroviral activity and could be withdrawn without viral rebound.
authors.forename: Christophe
authors.initials: C
authors.lastname: Piketty
authors.forename: Laurence
authors.initials: L
authors.lastname: Gérard
authors.forename: Corine
authors.initials: C
authors.lastname: Chazallon
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
authors.forename: François
authors.initials: F
authors.lastname: Clavel
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Taburet
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Girard
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Aboulker
mesh_terms: D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D009154:Mutation / Q000235:genetics; D012367:RNA, Viral / Q000032:analysis; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D017211:Treatment Failure; D019562:Viral Load
chemical_list: D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors