title: TFF peptides in the human false vocal folds of the larynx.
abstract: TFF peptides (formerly P domain peptides, trefoil factors) are typical secretory products of mucin-producing cells and are thought to influence the rheological properties of mucous gels. We investigated the localization of these peptides in the human false vocal folds of the larynx, also known as the ventricular folds or vestibular folds. An analysis of TFF peptide mRNA by RT-PCR and TFF protein by Western blot detected TFF1 and TFF3, but not TFF2. Immunohistochemistry revealed TFF1 to be associated with the secretory product of goblet cells and mucous parts of subepithelial seromucous glands. TFF3 occurred in columnar epithelial cells of the mucosa and in serous cells and excretory duct cells of seromucous glands. These peptides may play a role in the rheological function of mucus secreted onto the true vocal folds and are thus important constituents of vocal production.
authors.affiliation: Institute of Anatomy, Christian Albrecht University of Kiel, Germany.
authors.forename: Hannes
authors.initials: H
authors.lastname: Kutta
authors.forename: Philipp
authors.initials: P
authors.lastname: Steven
authors.forename: Deike
authors.initials: D
authors.lastname: Varoga
authors.forename: Friedrich P
authors.initials: FP
authors.lastname: Paulsen
mesh_terms: D000328:Adult; D000368:Aged; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007830:Larynx / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins; D014827:Vocal Cords / Q000378:metabolism* / Q000473:pathology
chemical_list: D009077:Mucins; D009124:Muscle Proteins; D010455:Peptides; D011506:Proteins; D012333:RNA, Messenger; C051838:TFF1 protein, human; C000604007:TFF2 protein, human; C082495:TFF3 protein, human; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins