title: Vaccine adjuvant: it makes the difference.
abstract: The use of protein or DNA in vaccination process rather than living or attenuated microorganism, aims at the increase of the vaccines safety. However, in these cases, the use of adjuvant is frequently required to improve their immunogenicity. In this study, we show the importance of the adjuvant in a vaccine formulation. Vaccines for tuberculosis provide an instructive example, based on the mycobacterial 65 kDa heat shock protein (hsp65). The same antigen can elicit completely different patterns of immune response depending on how it is administered. Thus, the same antigen might or not protect mice from challenge with Mycobacterium tuberculosis, depending on the formulation. These data suggest that, despite the name, the adjuvant plays a fundamental role on the vaccination process.
authors.affiliation: Center for Tuberculosis Research, School of Medicine of Ribeirão Preto, Instituto do Milênio Rede-TB, University of São Paulo, Avenue Bandeirantes 3900, Ribeirão Preto, São Paulo 14049-900, Brazil.
authors.forename: Karla M
authors.initials: KM
authors.lastname: Lima
authors.forename: Sandra Aparecida
authors.initials: SA
authors.lastname: dos Santos
authors.forename: José M
authors.initials: JM
authors.lastname: Rodrigues
authors.forename: Célio L
authors.initials: CL
authors.lastname: Silva
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001426:Bacterial Proteins / Q000276:immunology; D018834:Chaperonin 60; D018833:Chaperonins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D032581:Tuberculosis Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D001426:Bacterial Proteins; D018834:Chaperonin 60; D032581:Tuberculosis Vaccines; D019444:Vaccines, DNA; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins