[Protein hormones, receptors, and other proteins in mechanisms of hormonal regulation].
The amino acid sequence of porcine beta-lipotropin was the first protein primary structure studied in Russia. This peptide as well as ACTH is liberated after proteolysis of proopiomelanocortin (POMC). alpha-MSH and beta-MSH (melanocortins), which are the fragments of ACTH and beta-lipotropin respectively, are the mediators of leptin action on appetite and lipid metabolism. The structure and molecular aspects of hormone signaling of the membrane receptors of leptin and melanocortins were analysed in the connection to the regulation of food consumption, growth, and puberty. Some aspects of insulin receptor and IGF-I receptor as well as intracellular receptors of lipid hormones (steroid and thyroid hormones) were also discussed. The postulate: "All organs, tissues, and cells of humans and animals are endocrine" is formulated on the basis of the accumulated data.
Pankov
Iu A
IuA
Endocrine Research Centre of RAMS, Moscvorechye str. 1, Moscow, 115478 Russia. yuri-pankov@mtu-net.ru
D000324:Adrenocorticotropic Hormone / Q000737:chemistry / Q000502:physiology; D000818:Animals; D001671:Biochemistry / Q000266:history / Q000639:trends; D004703:Endocrine System / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D020738:Leptin / Q000737:chemistry / Q000502:physiology; D036361:Peptide Hormones / Q000502:physiology*; D011487:Protein Conformation; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000502:physiology; D018000:Receptors, Peptide / Q000502:physiology*; D008083:beta-Lipotropin / Q000737:chemistry / Q000502:physiology
D020738:Leptin; D036361:Peptide Hormones; D018160:Receptors, Cytoplasmic and Nuclear; D018000:Receptors, Peptide; D000324:Adrenocorticotropic Hormone; D008083:beta-Lipotropin