Immune responses to strenuous exercise and carbohydrate intake in boys and men.
Few studies describe immune responses to exercise in children, compared with adults, and none have investigated the influence of carbohydrate (CHO) intake. We hypothesized less perturbation and a faster recovery of the immune system with exercise in children, regardless of supplemental energy. Twelve boys (9.8 +/- 0.1 y) and 10 men (22.1 +/- 0.5 y) cycled for 60 min at 70% o(2max) while drinking 6% CHO (CHO-T) or flavored water (FW-T). Blood samples were collected before (PRE), immediately after (POST), and 60 min after (REC) exercise. Boys, compared with men, had smaller (p < 0.05) increases in total leukocytes (28% versus 38%), natural killer (NK) cells (78% versus 236%), and NK T cells (42% versus 128%) at POST, averaged across beverage trials. Exercise did not increase tumor necrosis factor-alpha (TNF-alpha), but significantly (p < 0.05) increased IL-6 in men (189%), but not in boys (11%). In both trials, lymphocytes and T cells at REC were suppressed (p < 0.05), relative to PRE, in men (-21%), but not in boys (4%). IL-6 remained elevated ( p< 0.001) in men at REC, with no change from POST in boys. In boys, but not in men, CHO significantly (p < 0.05) attenuated increases in neutrophil, lymphocyte, and NK cell counts at POST. Neutrophils at REC in CHO-T were lower (p < 0.05) than in FW-T in men ( approximately 25%) and in boys ( approximately 17%). CHO had no effect on TNF-alpha or IL-6 in either group. Our results indicate a distinct pattern of the immune response to exercise and CHO intake in boys, compared with men.
Timmons
Brian W
BW
Children's Exercise and Nutrition Centre, Chedoke Hospital, Evel Bldg. (4 floor), Sanatorium Road, Hamilton, Ontario, Canada L8N 3Z5.
Tarnopolsky
Mark A
MA
Bar-Or
Oded
O
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D004040:Dietary Carbohydrates / Q000378:metabolism*; D015444:Exercise; D006801:Humans; D007107:Immune System / Q000502:physiology*; D015850:Interleukin-6 / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha