title: Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.
abstract: While the initiation of the adaptive and innate immune response is well understood, less is known about cellular mechanisms propagating inflammation. The receptor for advanced glycation end products (RAGE), a transmembrane receptor of the immunoglobulin superfamily, leads to perpetuated cell activation. Using novel animal models with defective or tissue-specific RAGE expression, we show that in these animal models RAGE does not play a role in the adaptive immune response. However, deletion of RAGE provides protection from the lethal effects of septic shock caused by cecal ligation and puncture. Such protection is reversed by reconstitution of RAGE in endothelial and hematopoietic cells. These results indicate that the innate immune response is controlled by pattern-recognition receptors not only at the initiating steps but also at the phase of perpetuation.
authors.affiliation: Department of Molecular Immunology, Division of Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Liliensiek
authors.forename: Markus A
authors.initials: MA
authors.lastname: Weigand
authors.forename: Angelika
authors.initials: A
authors.lastname: Bierhaus
authors.forename: Werner
authors.initials: W
authors.lastname: Nicklas
authors.forename: Michael
authors.initials: M
authors.lastname: Kasper
authors.forename: Stefan
authors.initials: S
authors.lastname: Hofer
authors.forename: Jens
authors.initials: J
authors.lastname: Plachky
authors.forename: Herman-Josef
authors.initials: HJ
authors.lastname: Gröne
authors.forename: Florian C
authors.initials: FC
authors.lastname: Kurschus
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Shi Du
authors.initials: SD
authors.lastname: Yan
authors.forename: Eike
authors.initials: E
authors.lastname: Martin
authors.forename: Erwin
authors.initials: E
authors.lastname: Schleicher
authors.forename: David M
authors.initials: DM
authors.lastname: Stern
authors.forename: G ünterJ
authors.initials: Gü
authors.lastname: Hämmerling G
authors.forename: Peter P
authors.initials: PP
authors.lastname: Nawroth
authors.forename: Bernd
authors.initials: B
authors.lastname: Arnold
mesh_terms: D000818:Animals; D002432:Cecum / Q000293:injuries; D007107:Immune System / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D010538:Peritonitis / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D018805:Sepsis / Q000378:metabolism*; D012772:Shock, Septic / Q000378:metabolism; D013997:Time Factors
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic