title: Suitability of bupropion SR for nicotine-dependent smokers: problems in a practice setting.
abstract: BACKGROUND
  Bupropion SR (Zyban) has been shown in randomized controlled trials to be an efficacious pharmacological aid for smoking cessation; however, recent reports have raised serious concerns about the breadth of its applicability without complications or contraindications.
  
  
  METHODS
  We examined this issue in a well-documented medical population, i.e. veterans volunteering to participate in a smoking cessation treatment research program involving the use of bupropion SR.
  
  
  RESULTS
  Overall, 22% of the 78 subjects who met the study criteria were appropriate for and completed the course of medication.
  
  
  CONCLUSIONS
  Thus, bupropion SR in nicotine-dependent veterans may not be broadly applicable when conservative prescribing guidelines are carefully followed.
authors.affiliation: VA Sierra Nevada Health Care System, Reno, NV, USA. Barbarak@unr.edu
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Kohlenberg
authors.forename: David O
authors.initials: DO
authors.lastname: Antonuccio
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hayes
authors.forename: Elizabeth V
authors.initials: EV
authors.lastname: Gifford
authors.forename: Melissa P
authors.initials: MP
authors.lastname: Piasecki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016642:Bupropion / Q000627:therapeutic use*; D000075202:Contraindications; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016540:Smoking Cessation / Q000379:methods*; D014029:Tobacco Use Disorder / Q000188:drug therapy*
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion