Local protein synthesis during axon guidance and synaptic plasticity.
mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of systems have provided insight into the specific roles of local protein synthesis during axonal navigation and during synaptic plasticity, and have begun to delineate the mechanisms underlying mRNA localization and regulated translation. Several powerful new tools have recently been developed to visualize each of these processes.
Martin
Kelsey C
KC
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Gonda Research Building 3506C, 695 Charles Young Drive South, Los Angeles, California 90095-1761, USA. kcmartin@mednet.ucla.edu
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009473:Neuronal Plasticity / Q000502:physiology*; D014176:Protein Biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger