title: Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives.
abstract: The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1-12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7-9 also exhibited potent in vivo activity.
authors.affiliation: The Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA. narasimhulu.naidu@bms.com
authors.forename: B Narasimhulu
authors.initials: BN
authors.lastname: Naidu
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Sorenson
authors.forename: Thomas
authors.initials: T
authors.lastname: Hudyma
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Zheng
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Joanne J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pucci
authors.forename: Junius M
authors.initials: JM
authors.lastname: Clark
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Ueda
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000187:drug effects; D036341:Intercellular Signaling Peptides and Proteins; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C463319:nocathiacin I; D014867:Water