title: Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer.
abstract: This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.
authors.affiliation: Laboratoire d'immunologie, Faculté de Médecine, UMR CNRS 6101, 2 rue Dr. Marcland, Limoges, France. yves.denizot@unilim.fr
authors.forename: Yves
authors.initials: Y
authors.lastname: Denizot
authors.forename: Véronique
authors.initials: V
authors.lastname: Truffinet
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bouvier
authors.forename: Alain
authors.initials: A
authors.lastname: Gainant
authors.forename: Pierre
authors.initials: P
authors.lastname: Cubertafond
authors.forename: Muriel
authors.initials: M
authors.lastname: Mathonnet
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011446:Prospective Studies
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase