Multiple functions of nuclear DNA helicase II (RNA helicase A) in nucleic acid metabolism.
Nuclear DNA helicase II (NDH II), or RNA helicase A (RHA), was initially discovered in mammals by conventional protein purification methods. Molecular cloning identified apparent sequence homologies between NDH II and a Drosophila protein named maleless (MLE), the latter being essential for the Drosophila X-chromosome dosage compensation. Increasing amounts of evidence suggest that NDH II is involved in multiple aspects of cellular and viral DNA and RNA metabolism. Moreover the functions of NDH II may have potential clinical implications related to viral infection, autoimmune diseases, or even tumorigenesis.
Zhang
Suisheng
S
Department of Biochemistry, Institute of Molecular Biotechnology, Beutenbergstrasse 11, D-07745 Jena, Germany.
Grosse
Frank
F
D000818:Animals; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D053487:DEAD-box RNA Helicases; D004247:DNA / Q000378:metabolism*; D004265:DNA Helicases / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D015967:Gene Expression Regulation, Viral / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D009696:Nucleic Acids / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D020365:RNA Helicases / Q000737:chemistry / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology*
D002868:Chromosomal Proteins, Non-Histone; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D009696:Nucleic Acids; D014157:Transcription Factors; C070837:mle protein, Drosophila; D012313:RNA; D004247:DNA; C098487:DHX9 protein, human; D004265:DNA Helicases; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases