Leucopyrokinin (LPK) analog [d-Ala(5)]-[2-8]-LPK inhibits LPK-induced analgesia in rats.
It has been previously found in our laboratory that insect neuropeptide leucopyrokinin and [2-8]-leucopyrokinin, a truncated analog without the first aminoacid of leucopyrokinin peptide chain exert an antinociceptive effect in rats. The present study confirmed our previous results, and moreover it has been found that [d-Ala(5)]-[2-8]-leucopyrokinin, an analog of leucopyrokinin antagonized the antinociceptive effect of leucopyrokinin and of [2-8]-leucopyrokinin. We conclude that this synthetic analog is a probable leucopyrokinin antagonist.
Plech
Andrzej
A
Department of Pharmacology of the Medical Faculty in Zabrze of the Medical University of Silesia, H Jordana 38, PL 41-808 Zabrze, Poland. aplech@slam.katowice.pl
Rykaczewska-Czerwińska
Monika
M
Konopińska
Danuta
D
D000700:Analgesics / Q000037:antagonists & inhibitors*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009842:Oligopeptides / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar
C495937:(d-Ala(5))-(2-8)-LPK, leucopyrokinin analog; D000700:Analgesics; D009842:Oligopeptides; D010446:Peptide Fragments; C049557:leucopyrokinin; D011761:Pyrrolidonecarboxylic Acid