title: Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives.
abstract: A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea.
authors.forename: Jin
authors.initials: J
authors.lastname: Sung Kim
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Myung-Eun
authors.initials: ME
authors.lastname: Suh
authors.forename: Hea-Young Park
authors.initials: HY
authors.lastname: Choo
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Hyen Joo
authors.initials: HJ
authors.lastname: Park
authors.forename: Choonmi
authors.initials: C
authors.lastname: Kim
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Chong-Ock
authors.initials: CO
authors.lastname: Lee
mesh_terms: D045744:Cell Line, Tumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D012235:Rhodamines / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D010793:Phthalazines; D012235:Rhodamines; C022027:lissamine rhodamine B; C043388:phthalazine