title: A simple approach to sensor discovery and fabrication on self-assembled monolayers on glass.
abstract: Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (microCP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.
authors.affiliation: Department of Supramolecular Chemistry and Technology, Applied Optics Group, Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Lourdes
authors.initials: L
authors.lastname: Basabe-Desmonts
authors.forename: Joris
authors.initials: J
authors.lastname: Beld
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Zimmerman
authors.forename: Jordi
authors.initials: J
authors.lastname: Hernando
authors.forename: Petra
authors.initials: P
authors.lastname: Mela
authors.forename: María F
authors.initials: MF
authors.lastname: García Parajó
authors.forename: Niek F
authors.initials: NF
authors.lastname: van Hulst
authors.forename: Albert
authors.initials: A
authors.lastname: van den Berg
authors.forename: David N
authors.initials: DN
authors.lastname: Reinhoudt
authors.forename: Mercedes
authors.initials: M
authors.lastname: Crego-Calama