Rapidly progressive dementia due to Mycobacterium neoaurum meningoencephalitis.
Dementia developed in a patient with widespread neurologic manifestations; she died within 5 months. Pathologic findings showed granulomatous inflammation with caseation necrosis, foreign body-type giant cells, and proliferative endarteritis with vascular occlusions. Broad-range polymerase chain reaction identified Mycobacterium neoaurum as the possible pathogen. Central nervous system infection by M. neoaurum may result in rapidly progressive dementia.
Heckman
George A
GA
Department of Medicine, Hamilton Health Sciences, Freeport Health Centre, Kitchener, Ontario, Canada. heck0@sympatico.ca
Hawkins
Cynthia
C
Morris
Andrew
A
Burrows
Lori L
LL
Bergeron
Catherine
C
D003704:Dementia / Q000382:microbiology* / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008590:Meningoencephalitis / Q000382:microbiology* / Q000503:physiopathology*; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000382:microbiology / Q000503:physiopathology; D009170:Nontuberculous Mycobacteria / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D013997:Time Factors