Galanin-like peptide gene expression in the hypothalamus and posterior pituitary of the obese fa/fa rat.
We examined the galanin-like peptide (GALP) gene expression in the arcuate nucleus (ARC) and posterior pituitary (PP) in 6- and 18-week-old male obese fa/fa rats. GALP mRNA in the ARC in fa/fa rats was significantly decreased in 6- and 18-week-old and GALP mRNA in the PP in fa/fa rats was significantly increased in 18-week-old compared to lean Fa/? rats. Insulin treatment in hyperglycemic fa/fa rats partially reversed those changes. These results suggest that the GALP gene expression in fa/fa rats might be regulated in part by leptin-independent mechanisms.
Saito
Jun
J
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Ozaki
Yumi
Y
Kawasaki
Makoto
M
Ohnishi
Hideo
H
Okimoto
Nobukazu
N
Nakamura
Toshitaka
T
Ueta
Yoichi
Y
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000737:chemistry / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D044089:Galanin-Like Peptide / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D006943:Hyperglycemia / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D020738:Leptin / Q000378:metabolism; D008297:Male; D009478:Neuropeptide Y / Q000235:genetics / Q000378:metabolism; D009765:Obesity / Q000235:genetics / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000737:chemistry / Q000378:metabolism*; D011333:Pro-Opiomelanocortin / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains
D001786:Blood Glucose; D044089:Galanin-Like Peptide; D007328:Insulin; D020738:Leptin; D009478:Neuropeptide Y; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin