Neuroimaging in disorders of cortical development.
Malformations of cortical development are important causes of developmental delay and epilepsy. They are classified by the presumed stage during which normal development is interrupted: neuronal proliferation and differentiation, neuronal migration, and late migration/cortical organization. This article discusses the important malformations in each of these groups, how and why the malformations develop, and their imaging findings. A better understanding of these disorders helps in genetic counseling of the parents and may help in the treatment of associated epilepsy.
Barkovich
A James
AJ
Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143, USA. jimb@radiology.ucsf.edu
Raybaud
Charles A
CA
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000196:embryology*; D006801:Humans; D009421:Nervous System Malformations / Q000000981:diagnostic imaging / Q000196:embryology* / Q000473:pathology*; D011859:Radiography