title: [Risk factors and 28 year morbidity and mortality of coronary heart disease in a cohort with a low incidence of the disease: the Manresa Study].
abstract: BACKGROUND
  To Study the incidence of coronary heart disease (CHD) and all-cause mortality in a cohort of men followed during 28 years, and their association with serum cholesterol, systolic blood pressure, glycemia, cigarette smoking and body mass index measured at baseline.
  
  
  METHODS
  A cohort of 1,059 men aged 30 to 59 years and free of cardiovascular diseases at baseline in 1968, was reexamined every five years until 1988. The last examination was performed in 1996. Information was collected on 96.4% of the participants.
  
  
  RESULTS
  Incidence and mortality rates from CHD and from all-causes of death per 10(5) person-years of observation were 499.80, 235.80 y 925.33, respectively. At the end of follow-up, high levels of serum cholesterol and smoking were independently associated with the incidence and mortality from CHD controlling by age, blood pressure, glycemia and BMI. Serum cholesterol, hyperglycemia and smoking were independently associated with all-cause mortality.
  
  
  CONCLUSIONS
  In this industrial cohort of men, with relative low incidence of CHD, smoking and serum cholesterol at baseline remained associated with the incidence of CHD through 28 years of observation.
authors.affiliation: Servicio de Cardiología, Hospital de Sant. Pau, Av. S.A.M. Claret 167 08025-Barcelona. ltomas@hps.simtpan.es
authors.forename: Luis Tomás
authors.initials: LT
authors.lastname: Abadal
authors.forename: Cristina
authors.initials: C
authors.lastname: Varas Lorenzo
authors.forename: Iñaki
authors.initials: I
authors.lastname: Pérez
authors.forename: Teresa
authors.initials: T
authors.lastname: Puig
authors.forename: Ignacio
authors.initials: I
authors.lastname: Balaguer Vintró
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003327:Coronary Disease / Q000401:mortality*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors