Solution structure of a PAN module from the apicomplexan parasite Eimeria tenella.
Micronemes, specialised organelles found in all apicomplexan parasites, secrete molecules that are essential for parasite attachment and invasion of host cells. EtMIC5 is one such microneme protein that contains eleven tandemly repeating modules. These modules have homology with the PAN module superfamily. Members of this family are found in blood clotting proteins, some growth factors and some nematode proteins. This paper presents the structure of the 9th PAN module in EtMIC5, determined using high resolution NMR. The structure shows similarities to and some differences from the N-terminal module of hepatocyte growth factor (HGF), the only previous member of the PAN family with known structure.
Brown
Philip J
PJ
Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK.
Mulvey
Denise
D
Potts
Jennifer R
JR
Tomley
Fiona M
FM
Campbell
Iain D
ID
D000595:Amino Acid Sequence; D000818:Animals; D001779:Blood Coagulation Factors / Q000737:chemistry / Q000235:genetics; D016786:Eimeria tenella / Q000737:chemistry* / Q000235:genetics; D015870:Gene Expression; D006023:Glycoproteins / Q000737:chemistry* / Q000235:genetics; D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D009348:Nematoda / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary / Q000235:genetics; D015800:Protozoan Proteins / Q000737:chemistry* / Q000235:genetics; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D040681:Structural Homology, Protein
D001779:Blood Coagulation Factors; D006023:Glycoproteins; D015800:Protozoan Proteins; D011994:Recombinant Proteins; C408742:microneme protein 5, Eimeria tenella; D017228:Hepatocyte Growth Factor