Drosophila gastrulation: identification of a missing link.
Drosophila gastrulation serves as a model system to elucidate the genetic and molecular mechanisms involved in morphogenetic movements. The ligand of the FGF receptor Heartless, which is involved in mesoderm movement, has now been isolated and shown to be a link between a morphogen gradient and cell behavior.
Leptin
Maria
M
Institute of Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany. mleptin@uni-koeln.de
Affolter
Markus
M
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins / Q000378:metabolism*; D005775:Gastrula; D018507:Gene Expression Regulation, Developmental; D008024:Ligands; D008648:Mesoderm / Q000378:metabolism / Q000502:physiology; D009024:Morphogenesis; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D029721:Drosophila Proteins; D008024:Ligands; D017468:Receptors, Fibroblast Growth Factor; D011505:Protein-Tyrosine Kinases; C102667:htl protein, Drosophila