Cancer cell biology: Myc wins the competition.
During Drosophila development, cells with elevated levels of the Myc oncoprotein grow faster than, and induce cell death in, nearby wild-type cells, suggesting how inappropriate Myc over-expression provides cells with a competitive advantage that can lead to cancer.
Donaldson
Timothy D
TD
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Duronio
Robert J
RJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D009369:Neoplasms / Q000503:physiopathology*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C102283:Max protein, Drosophila; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors