title: Serum levels of manganese superoxide dismutase in patients with localized scleroderma.
abstract: The objective was to determine the serum levels of manganese superoxide dismutase (Mn SOD) in patients with localized scleroderma and investigate their clinical significance in this disease. Serum samples from 15 patients with localized scleroderma and 20 healthy volunteers were examined by a specific enzyme-linked immunosorbent assay. Serum levels of Mn SOD were significantly higher in patients with generalized morphea than those in healthy individuals. And the patients with elevated serum Mn SOD levels had significantly larger number of sclerotic lesions and significantly higher serum levels of soluble interleukin-2 receptor than those without it. These results suggested that the serum levels of this enzyme may be a serological marker for the disease activity and the extent of skin involvement in this disease.
authors.affiliation: Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo-Ku, Tokyo, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Jinnin
authors.forename: Hironobu
authors.initials: H
authors.lastname: Ihn
authors.forename: Norihito
authors.initials: N
authors.lastname: Yazawa
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamane
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D000328:Adult; D017668:Age of Onset; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D012594:Scleroderma, Localized / Q000097:blood* / Q000473:pathology*; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D015415:Biomarkers; D013482:Superoxide Dismutase