title: Comparison of frequency of interferon-gamma-positive CD4+ T cells before and after percutaneous coronary intervention and the effect of statin therapy in patients with stable angina pectoris.
abstract: We investigated the effect of statin therapy on T-cell activation in patients who underwent percutaneous coronary intervention by using flow cytometric analysis. The increased frequency of interferon-gamma-positive CD4(+) T cells after percutaneous coronary intervention was significant in the group treated without statins but not in the group treated with statins.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tanaka
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hirai
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kajiwara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyao
authors.forename: Kazuteru
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Hiroo
authors.initials: H
authors.lastname: Miyagi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irie
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000276:immunology / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000276:immunology / Q000628:therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007371:Interferon-gamma / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007371:Interferon-gamma