[Efficacy of cytoprotective agent Mexicor in urgent cardiology].
OBJECTIVE
To study efficacy of cytoprotector mexicor in patients with unstable angina (UA), acute myocardial infarction (MI), hypertensive crises (HC) in combined therapy with conventional drugs.


METHODS
An open randomized study included 338 patients with acute forms of ischemic heart disease (IHD) and arterial hypertension running with crises. Combined therapy of 20 patients with UA, 90 patients with MI and 43 patients with HC (study groups) was supplemented with mexicor in a dose 6-9 mg/kg/day. The control matched patients (20, 86 and 79 patients, respectively) received conventional treatment alone. The effects of the treatments were assessed by ultrasound investigation of the heart in M-, B- and Doppler modes, by ECG and arterial pressure 24-h monitoring, by activity of lipid peroxidation (LPO).


RESULTS
Adjuvant therapy of urgent cardiological conditions with mexicor diminished oxidant stress, left ventricular dysfunction. In MI patients mexicor promoted reduction of the akinesia zones, recovery of disturbed segmentary contractility. In UA patients mexicor contributed to more pronounced decrease in the frequency, duration and severity of myocardial ischemia, enhanced stabilization of angina. In HC patients mexicor promoted earlier normalization of a 24-h AP profile and variability of cardiac rhythm, recurrence rate of HC decreased 2-fold.


CONCLUSIONS
The addition of mexicor to conventional therapy of UA, MI, HC improves clinical course of these diseases, reduces oxidant stress, accelerates recovery of cardiac contractility and left ventricular diastolic function, normalization of central hemodynamics.
Golikov
A P
AP
Mikhin
V P
VP
Boĭtsov
S A
SA
Bogoslovskaia
E N
EN
Vesel'eva
N V
NV
Luk'ianov
M M
MM
Rudnev
D V
DV
Frolov
A A
AA
D000789:Angina, Unstable / Q000000981:diagnostic imaging / Q000188:drug therapy*; D019610:Cytoprotection / Q000187:drug effects; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D006321:Heart; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010847:Picolines / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage*; D016277:Ventricular Function, Left / Q000187:drug effects
D010847:Picolines; D014665:Vasodilator Agents; C009820:6-methyl-2-ethyl-3-hydroxypyridine