[Clinical study on treatment of mild cognitive impairment by modified wuzi yanzong granule].
OBJECTIVE
To observe the clinical efficacy and safety of modified Wuzi Yanzong Granule (MWYG) in treating mild cognitive impairment (MCI), and to explore its mechanism.


METHODS
Forty-four MCI patients were selected referring to the international recognized Peterson's criteria and randomly divided into two groups, the treated group treated with MWYG and the control group treated with Ginkgo leaf extraction, with the course of 3 months for both groups. Changes of memorial quotient (MQ), superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, mitochondrial DNA (mtDNA) deletion rate and acetylcholinesterase (AchE) before and after treatment were observed.


RESULTS
After treatment, levels of MQ, serum SOD activity increased and serum MDA content, mtDNA deletion rate and AchE decreased in both groups (P < 0.01), but the difference between the two groups was insignificant. No adverse reaction was found in two groups.


CONCLUSIONS
Both MWYG and Ginkgo leaf capsule can effectively improve the memorial function of patients with MCI, the therapeutic mechanism is possibly related with the actions in reducing AchE activity, improving free radical metabolism, and alleviating mitochondrial DNA oxidation damage.
Wang
Xue-mei
XM
First Hospital, Peking University, Beijing 100034. wangxuemei64@sohu.com
Fu
Hong
H
Liu
Geng-xin
GX
D000368:Aged; D003072:Cognition Disorders / Q000097:blood / Q000188:drug therapy*; D004272:DNA, Mitochondrial / Q000097:blood; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D020441:Ginkgo biloba; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D008517:Phytotherapy; D013482:Superoxide Dismutase / Q000097:blood
D004272:DNA, Mitochondrial; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase