Selective serotonin-reuptake inhibitors for the treatment of hot flashes.
OBJECTIVE
To review the literature evaluating the use of selective serotonin-reuptake inhibitors (SSRIs) for the treatment of hot flashes.


METHODS
Biomedical literature was accessed through MEDLINE (1966-June 2003), MD Consult, and references of reviewed articles. Key search terms used were hot flashes, vasomotor symptoms, antidepressants, and SSRIs.


RESULTS
Recent evidence from the Women's Health Initiative precludes the use of traditional hormonal therapy in some women. Nonhormonal therapies are possible options, but conflicting evidence of efficacy exists.


CONCLUSIONS
Although further studies are warranted, preliminary data suggest that SSRIs are generally modestly successful in reducing the frequency and severity of hot flashes.
De Sloover Koch
Yvonne
Y
Department of Veterans Affairs Medical Center, Iowa City, IA 52242-1097, USA.
Ernst
Michael E
ME
D002986:Clinical Trials as Topic; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
D017367:Selective Serotonin Reuptake Inhibitors