Issues and challenges in developing long-acting veterinary antibiotic formulations.
Antibiotics are an important class of therapeutic agents, which are used for the treatment of bacterial infectious diseases in a variety of animal species. Antibiotic therapy varies from treatment period to administration routes, depending on the animal species or the type of the disease being treated. Despite the fact that there are a wide variety of commercially available antibiotics, difficulties and problems associated with the administration of antibiotics to animals still exist. Thus, there is a great need and tremendous opportunity to develop long-acting antibiotic formulations for veterinary applications. In this review article, common approaches used to develop long-acting antibiotic formulations are summarized. The challenges and issues related to the development of these long-acting formulations are also discussed.
Sun
Yichun
Y
Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, 26 South Dunlap Street, 214 Feurt Building, Memphis, TN, 38163, USA. ysun@utmem.edu
Scruggs
Daniel W
DW
Peng
Yingxu
Y
Johnson
James R
JR
Shukla
Atul J
AJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy / Q000662:veterinary*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D024881:Drug Resistance, Bacterial; D004355:Drug Stability
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations