title: Stereoselective construction of eight-membered oxygen heterocycles by Brook rearrangement-mediated [3 + 4] annulation.
abstract: [reaction: see text] A newly developed strategy for eight-membered oxygen heterocycle construction via [3 + 4] annulation is described. The method involves the combination of beta-substituted acryloylsilanes and enolates of 6-oxacyclohept-2-en-1-one. A unique feature of this annulative approach is its capacity to generate eight-membered ring systems containing useful functionalities for further synthetic elaboration from readily available three- and four-carbon components.
authors.affiliation: Department of Synthetic Organic Chemistry, Graduate School of Medical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sawada
authors.forename: Michiko
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kei
authors.initials: K
authors.lastname: Takeda