Leukemia-like syndrome in Balb/c mice infected with the lymphotropic gamma herpesvirus MHV-Sumava: an analogy to EBV infection.
Based on our previous observation that primary infection with the murine gamma herpesvirus (MHV) isolate Sumava (MHV-SU) undergoes a lymphoproliferative phase resembling to Epstein-Barr virus (EBV) induced infectious mononucleosis (IM), we evaluated white blood cell (WBC) counts at late stages following MHV-SU infection. In consequence of intranasal inoculation with MHV-SU a leukemia-like syndrome in Balb/c mice developed. The syndrome in question was accompanied with significant splenomegaly; in the peripheral blood leukocytosis (from 8 x 10(4) to 5 x 10(5) leukocytes/microl) and a high percentage of atypical lymphocytes (60-80%) was found. Presented results are bringing further evidence for lymphoproliferative effect of MHV and point at analogic course of MHV-SU and EBV infections.
Mistríková
J
J
Department of Microbiology and Virology, Comenius University, Faculty of Natural Sciences, 842 15 Bratislava, Slovak Republic. virumis@savba.sk
Mrmusová-Supolíková
M
M
Rajcáni
J
J
D000818:Animals; D004195:Disease Models, Animal; D020031:Epstein-Barr Virus Infections / Q000473:pathology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D018142:Gammaherpesvirinae / Q000378:metabolism*; D007938:Leukemia / Q000473:pathology* / Q000821:virology*; D007962:Leukocytes / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D008856:Microscopy, Fluorescence; D009374:Neoplasms, Experimental; D016622:Silver Staining; D013154:Spleen / Q000166:cytology / Q000821:virology; D013577:Syndrome