title: Double allogeneic peripheral blood stem cell transplantation in a 9-year-old patient with relapsed acute lymphoblastic leukemia: case report.
abstract: A 9-year-old female patient with relapsed leukemia that was refractory to conventional reinduction chemotherapy was successfully treated with double allogeneic peripheral blood stem cell transplantation. The conditioning regimen for the first transplantation consisted of busulfan, etoposide, and melphalan, and that for the second transplantation was total body irradiation and thiotepa. Neither severe regimen-related toxicity nor graft-versus-host disease was observed. The patient is in complete remission without major complications for 5 years. Double transplantation should be considered as one of the possible treatments for refractory acute lymphoblastic leukemia.
authors.affiliation: Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. hfujii@med.yokohama-cu.ac.jp
authors.forename: Hisaki
authors.initials: H
authors.lastname: Fujii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Goto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Sakurako
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Sekiguchi
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Funabiki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ikuta
authors.forename: Shunpei
authors.initials: S
authors.lastname: Yokota
mesh_terms: D002648:Child; D018572:Disease-Free Survival; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods*; D013852:Thiotepa / Q000627:therapeutic use; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D017211:Treatment Failure; D014916:Whole-Body Irradiation
chemical_list: D013852:Thiotepa