Effect of edifenphos on compensatory ovarian hypertrophy, follicular kinetics and estrous cycle in hemicastrated rats.
Edifenphos, an organophosphate fungicide, was administered to hemicastrated albino rats intraperitoneally for 15 consecutive days in graded doses of 2 to 8 mg/kg body weight. In the oil-treated hemicastrated control group, ovarian weight and total number of healthy and atretic follicles were significantly higher than the same parameters in sham-operated control animals, and the estrous cycle was normal. Treatment with 2, 4, 6, or 8 mg/kg/d edifenphos significantly decreased ovarian weight (-6.75, -9.79, -18.71, and -34.13 percent, respectively) below that of the controls. Although treatment with 2 or 4 mg/kg/d edifenphos did not change the number of healthy and atretic follicles, a dosage of 4 mg/kg/d significantly decreased the number and duration of estrous cycles. Treatment with 6 or 8 mg/kg/d, however, significantly decreased the number and duration of different phases of the estrous cycle as well. In all treated groups, the weights of the thymus and uterus were significantly reduced when compared with those of hemicastrated oil-treated control animals.
Nanda
N
N
Reproductive Toxicology Laboratory, Post Graduate Department of Studies in Zoology, Karnatak University, Dharwad 58003, India.
Kaliwal
B B
BB
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D030762:Estrous Cycle / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005659:Fungicides, Industrial / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D006984:Hypertrophy / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D010052:Ovariectomy / Q000379:methods; D010053:Ovary / Q000187:drug effects* / Q000473:pathology* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects; D013997:Time Factors; D014599:Uterus / Q000187:drug effects
D005659:Fungicides, Industrial; D009946:Organothiophosphorus Compounds; C002108:edifenphos