Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus.
Adiponectin (Adipocyte Complement-Related Protein of 30 kDa, ACRP30) and resistin are adipocyte-derived polypeptide hormones playing a role in metabolic homeostasis. Their plasma levels are inversely (adiponectin) or directly (resistin) correlated to obesity and they have opposite effects on insulin sensitivity. Adipose tissue hormones such as leptin have been shown to modulate neurotransmitters which control feeding in the hypothalamus. We have studied the effects of adiponectin and resistin on dopamine, norepinephrine and serotonin release from hypothalamic neuronal endings (synaptosomes) in vitro. We have found that adiponectin does not modify either basal or depolarization-induced amine release, while resistin inhibits the stimulated release of dopamine and norepinephrine, leaving unaffected serotonin release. We can conclude that, similarly to leptin, but differently from adiponectin, the adipose tissue hormone resistin could affect the central mechanisms of feeding by inhibiting catecholamine release in the hypothalamus.
Brunetti
Luigi
L
Department of Drug Sciences, G. D'Annunzio University, via dei Vestini, 66013 Chieti, Italy.
Orlando
Giustino
G
Recinella
Lucia
L
Michelotto
Barbara
B
Ferrante
Claudio
C
Vacca
Michele
M
D052242:Adiponectin; D000818:Animals; D019540:Area Under Curve; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006729:Hormones, Ectopic / Q000737:chemistry / Q000494:pharmacology*; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000502:physiology*; D007558:Italy; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D052243:Resistin; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014316:Tritium
D052242:Adiponectin; D018492:Dopamine Antagonists; D006729:Hormones, Ectopic; D036341:Intercellular Signaling Peptides and Proteins; D052243:Resistin; C499622:Retn protein, rat; D014316:Tritium; D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine