title: Optimization of the primary collimator settings for fractionated IMRT stereotactic radiotherapy.
abstract: Advances in field-shaping techniques for stereotactic radiosurgery/radiotherapy have allowed dynamic adjustment of field shape with gantry rotation (dynamic conformal arc) in an effort to minimize dose to critical structures. Recent work evaluated the potential for increased sparing of dose to normal tissues when the primary collimator setting is optimized to only the size necessary to cover the largest shape of the dynamic micro multi leaf field. Intensity-modulated radiotherapy (IMRT) is now a treatment option for patients receiving stereotactic radiotherapy treatments. This multisegmentation of the dose delivered through multiple fixed treatment fields provides for delivery of uniform dose to the tumor volume while allowing sparing of critical structures, particularly for patients whose tumor volumes are less suited for rotational treatment. For these segmented fields, the total number of monitor units (MUs) delivered may be much greater than the number of MUs required if dose delivery occurred through an unmodulated treatment field. As a result, undesired dose delivered, as leakage through the leaves to tissues outside the area of interest, will be proportionally increased. This work will evaluate the role of optimization of the primary collimator setting for these IMRT treatment fields, and compare these results to treatment fields where the primary collimator settings have not been optimized.
authors.affiliation: University of Utah Health Science Center, Department of Radiation Oncology, Salt Lake City, UT 84132, USA. mattew.tobler@hsu.utah.edu
authors.forename: Matt
authors.initials: M
authors.lastname: Tobler
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Leavitt
authors.forename: Gordon
authors.initials: G
authors.lastname: Watson
mesh_terms: D001921:Brain / Q000528:radiation effects; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery; D019583:Dose Fractionation, Radiation; D006801:Humans; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000379:methods*; D012189:Retrospective Studies