title: The C-peptide signaling.
abstract: For years an assumption was made that C-peptide, a byproduct of insulin biosynthesis, possessed no appreciable physiologic role. As other contributions in this volume amply testify, the time has come to re-evaluate that notion. C-peptide either directly through interaction with its specific cell-surface receptor or indirectly through an interaction with a related membrane entity, exerts a unique effect on several intracellular processes. We review here results of studies attempting to elucidate such molecular effects of C-peptide in different cell systems and tissues. Lacking a purified C-peptide receptor, we also demonstrate C-peptide effects on distinct elements of the insulin signal transduction pathways.
authors.affiliation: Grunberger Diabetes Institute, Bloomfield Hills, Michigan 48302, USA.
authors.forename: George
authors.initials: G
authors.lastname: Grunberger
authors.forename: Anders A F
authors.initials: AA
authors.lastname: Sima
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002096:C-Peptide / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000502:physiology; D008138:Loop of Henle / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D032446:Myoblasts / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors; D015398:Signal Transduction
chemical_list: D002096:C-Peptide; D007328:Insulin; D017027:Protein Tyrosine Phosphatases