title: 0.2 T magnetic field inhibits angiogenesis in chick embryo chorioallantoic membrane.
abstract: Inhibition of angiogenesis is a major target in the fight against cancer and other diseases. Although the effects of static magnetic fields on cancer development and cell growth have been investigated, effects on angiogenesis have received no attention so far. In this study we report the effects on angiogenesis of exposure to 0.2 T static magnetic field. Angiogenesis was analyzed using the chick embryo chorioallantoic membrane assay. Exposure to 0.2 T static magnetic field was achieved by placing the eggs for 3 hr in the isocentre of the magnet of a sectorial magnetic resonance tomograph used in clinical practice. In sham exposed specimens treated with phosphate buffered saline (negative control), no significant vascular reaction was detectable; 3 hr exposure to 0.2 T static magnetic field did not affect the basal pattern of vascularization or chick embryo viability. Prostaglandin E1 and fetal calf serum elicited a strong angiogenic response in sham exposed eggs. This angiogenic response was significantly inhibited by 3 hr exposure to 0.2 T static magnetic field. These findings point to possible use of static magnetic field in inhibiting angiogenesis; this effect could be exploited for treatment of cancer and other diseases where excessive angiogenesis is involved.
authors.affiliation: Department of Experimental Pathology and Oncology, University of Firenze, Firenze, Italy. biolmol@yahoo.com
authors.forename: Marco
authors.initials: M
authors.lastname: Ruggiero
authors.forename: Donald P
authors.initials: DP
authors.lastname: Bottaro
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Liguri
authors.forename: Massimo
authors.initials: M
authors.lastname: Gulisano
authors.forename: Benedetta
authors.initials: B
authors.lastname: Peruzzi
authors.forename: Stefania
authors.initials: S
authors.lastname: Pacini
mesh_terms: D000482:Allantois / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D000527:Alprostadil / Q000494:pharmacology; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D005312:Fetal Blood; D008280:Magnetics; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000528:radiation effects*; D011829:Radiation Dosage; D013997:Time Factors
chemical_list: D043925:Angiogenesis Inducing Agents; D000527:Alprostadil