Azadirachta indica adversely affects sperm parameters and fructose levels in vas deferens fluid of albino rats.
Azadirachta indica treatment for 24 days in albino rats resulted in a decrease in the total sperm count, sperm motility, and forward velocity in vas deferens fluid. The percentage of abnormal sperm increased and the fructose content decreased. As diminished levels of fructose parallel androgen deficiency, we conclude that reduced androgen levels resulting from the anti-androgenic property of A. indica leaves probably influences the physiological maturation of sperm.
Ghosesawar
M G
MG
Post-Graduate Department of Zoology, Karnatak University, Dharwad 580 003, India.
Ahamed
R Nazeer
RN
Ahmed
Mukhtar
M
Aladakatti
R H
RH
D000284:Administration, Oral; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000737:chemistry; D000728:Androgens / Q000737:chemistry; D000818:Animals; D031601:Azadirachta / Q000009:adverse effects*; D005632:Fructose / Q000737:chemistry*; D007273:Injections, Intramuscular; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D018515:Plant Leaves / Q000009:adverse effects; D010946:Plants, Medicinal / Q000009:adverse effects; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*; D013739:Testosterone / Q000008:administration & dosage / Q000493:pharmacokinetics; D014649:Vas Deferens / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology
D000726:Androgen Antagonists; D000728:Androgens; D010936:Plant Extracts; D005632:Fructose; D013739:Testosterone