[Sterilizing effect of the mutant allele sbr10 (l(1)ts403) in compound with null alleles in Drosophila melanogaster females].
In females of Df(1)v-L4/+(0/+) genotype, the presence of the wild-type allele of small bristles (sbr) gene in a single dose has no significant effect on their fecundity, whereas a reduced dose of the temperature-sensitive allele sbr10(l(1)ts403) causes a strong sterilizing effect in females Df(1)v-L4/sbr10 (0/sbr10) at permissive temperature. We studied the contribution to this effects of the following factors: resorption of egg chambers, decreased oviposition, offspring death at the embryonic and larval stages, and reduced fecundity in females 0/sbr10. Sterilizing effect of the mutant sbr10 allele proved to be primarily caused by offspring lethality at the embryonic and first-instar larval stages. In 0/+ females, the majority of undeveloped eggs contained embryos that perished at the late developmental stages, whereas in females 0/sbr10, at least 50% of undeveloped egg showed no visible signs of development or the embryo development was arrested at early stages of embryogenesis. The results obtained suggest insufficiency of the temperature-sensitive allele sbr10 in haploid state to ensure the reproductive functions of Drosophila melanogaster females.
Golubkova
E V
EV
Department of Genetics and Breeding, St. Petersburg State University, St. Petersburg, 199034 Russia.
Pugacheva
O M
OM
Demina
E P
EP
Musorina
A S
AS
Shershabova
A N
AN
Mamon
L A
LA
D000483:Alleles; D000818:Animals; D004331:Drosophila melanogaster; D005260:Female; D007247:Infertility, Female / Q000235:genetics*; D009154:Mutation