Abnormal association between reduced magnetic mismatch field to speech sounds and smaller left planum temporale volume in schizophrenia.
Schizophrenia is associated with language-related dysfunction. A previous study [Schizophr. Res. 59 (2003c) 159] has shown that this abnormality is present at the level of automatic discrimination of change in speech sounds, as revealed by magnetoencephalographic recording of auditory mismatch field in response to across-category change in vowels. Here, we investigated the neuroanatomical substrate for this physiological abnormality. Thirteen patients with schizophrenia and 19 matched control subjects were examined using magnetoencephalography (MEG) and high-resolution magnetic resonance imaging (MRI) to evaluate both mismatch field strengths in response to change between vowel /a/ and /o/, and gray matter volumes of Heschl's gyrus (HG) and planum temporale (PT). The magnetic global field power of mismatch response to change in phonemes showed a bilateral reduction in patients with schizophrenia. The gray matter volume of left planum temporale, but not right planum temporale or bilateral Heschl's gyrus, was significantly smaller in patients with schizophrenia compared with that in control subjects. Furthermore, the phonetic mismatch strength in the left hemisphere was significantly correlated with left planum temporale gray matter volume in patients with schizophrenia only. These results suggest that structural abnormalities of the planum temporale may underlie the functional abnormalities of fundamental language-related processing in schizophrenia.
Yamasue
Hidenori
H
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113-8655, Japan. yamasue-tky@umin.ac.jp
Yamada
Haruyasu
H
Yumoto
Masato
M
Kamio
Satoru
S
Kudo
Noriko
N
Uetsuki
Miki
M
Abe
Osamu
O
Fukuda
Rin
R
Aoki
Shigeki
S
Ohtomo
Kuni
K
Iwanami
Akira
A
Kato
Nobumasa
N
Kasai
Kiyoto
K
D000328:Adult; D001931:Brain Mapping / Q000379:methods; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D012016:Reference Values; D012044:Regression Analysis; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology; D013060:Speech / Q000502:physiology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology