Translocation (8;22) in cold agglutinin disease associated with B-cell lymphoma.
Cold agglutinin disease (CAD) is a hemolytic anemia due to anti-red cell autoantibodies that are reactive at cold temperatures. In the elderly, it may be associated with underlying B-cell lymphoma, usually a lympho-plasmacytic lymphoma variant. We report a case of CAD in an elderly Indonesian female, which was associated with a B-cell lymphoma that showed a histologic appearance consistent with large-cell lymphoma. Cytogenetic analysis revealed the presence of trisomies 3 and 12, which have been reported previously in B-cell lymphoma associated with CAD. In addition, a t(8;22) was found in 24 out of 28 metaphases. Translocation (8;22) is associated with Burkitt lymphoma or acute lymphoblastic lymphoma, French-American-British subtype L3. It has not been previously reported in B-cell lymphoma asssociated with CAD, and could represent a blastic transformation of the underlying B-cell lymphoma.
Chng
Wee Joo
WJ
Division of Haematology, National University Hospital, Singapore 119074, Singapore. chngwj@nuh.com.sg
Chen
Jean
J
Lim
Susan
S
Chong
Siew Meng
SM
Kueh
Yan Koon
YK
Lee
Szu-Hee
SH
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000235:genetics*; D002051:Burkitt Lymphoma / Q000235:genetics; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020732:Cytogenetic Analysis / Q000379:methods; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics*