Defining the parameters necessary for T-cell recognition of ligands that vary in potency.
Identification of the mechanisms by which a T cell is able to sense ligands of varying strength, such as those that mediate tumor growth, viral evasion, and autoimmunity, is a major goal of T-cell activation studies. In recent years, parameters important for T-cell activation by strong ligands (agonists) are beginning to be characterized. Here, we review our current work on the factors that are critical for T-cell activation by ligands that differ in potency, typified by full agonists, weak agonists, partial agonists, and antagonists. Furthermore, we discuss mechanisms contributing to the lack of a full range of effector functions observed in T cells following their stimulation by suboptimal ligands. Finally, we present strategies for the design of peptide-based therapies to control activation of polyclonal, autoreactive T-cell populations.
Kilgore
Neely E
NE
Department of Microbiology and Immunology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.
Ford
Mandy L
ML
Margot
Carrie D
CD
Jones
Daniel S
DS
Reichardt
Peter
P
Evavold
Brian D
BD
D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases