title: Ventricular activation onset-triggered left ventricular pacing: safety and feasibility in initial clinical experience.
abstract: Ventricular activation onset-triggered (VAOT) left ventricular pacing modalities synchronize left ventricular paced activation with existing intrinsic ventricular activation, in patients with complete LBBB and adequate rate. The purpose of this study was to evaluate the safety and feasibility of VAOT pacing with one left ventricular pacing lead, during temporary pacing in the postoperative period following open heart surgery. VAOT pacing was studied in five patients with LBBB and two patients with previously implanted right ventricular pacemakers. The VAOT pacing system used was assembled by modifying the function of existing equipment and its programming is described in detail. Comparative ECGs are reported, documenting the changes in ventricular activation produced by VAOT pacing. Stability of surface ECG acquisition was found to be essential to the success of temporary VAOT pacing and inappropriate pacing due to ECG instability is described. Patients were studied at rest and none experienced congestive heart failure. In the comparison of cardiac output, with and without VAOT pacing, no significant differences were found in LBBB patients or those with right ventricular pacemakers. In the comparison of arterial pressure, with and without VAOT pacing, no significant differences were found in six patients, however, in one LBBB patient with intrinsic predominant ventricular trigeminy, VAOT pacing was observed to have an antiarrhythmic effect resulting in suppression of ventricular ectopy and stabilization of arterial pressure. All patients survived VAOT pacing and the postoperative period without complications requiring additional intervention or treatment.
authors.affiliation: Department of Cardiology, Boswell Memorial Hospital, Heart Center, Sun City, Arizona, USA. GLSinphx@hotmail.com
authors.forename: George K
authors.initials: GK
authors.lastname: Wong
authors.forename: Federico T
authors.initials: FT
authors.lastname: Florendo
authors.forename: Fred M
authors.initials: FM
authors.lastname: Cohen
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D002037:Bundle-Branch Block / Q000503:physiopathology / Q000628:therapy*; D002302:Cardiac Output / Q000502:physiology; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004562:Electrocardiography / Q000295:instrumentation*; D004867:Equipment Design; D006329:Heart Conduction System / Q000503:physiopathology; D006331:Heart Diseases / Q000601:surgery*; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D011182:Postoperative Care; D011183:Postoperative Complications / Q000503:physiopathology / Q000628:therapy*; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D012984:Software; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology / Q000628:therapy*