Alpha-synuclein aggregation.
Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease and is found associated with several other forms of dementia. As with other neurodegenerative diseases, the ability of alpha-synuclein to aggregate and form fibrillar deposits seems central to its pathology. We have defined a sequence within the NAC region of alpha-synuclein that is necessary for aggregation. Exploitation of chemically modified analogues of this peptide may produce inhibitors of aggregation.
Bodles
Angela M
AM
University of Arkansas for Medical Sciences, Donald W. Reynolds Center on Aging, Little Rock, AR 72205, USA. Abodles@uams.edu
Irvine
G Brent
GB
D000595:Amino Acid Sequence; D000686:Amyloidosis / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism*; D010300:Parkinson Disease / Q000378:metabolism; D020836:Protein Structure, Quaternary; D051843:Synucleins; D051844:alpha-Synuclein
D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein