title: Aminomethylpyridines as DPP-IV inhibitors.
abstract: In a novel series of DPP-IV inhibitors, a large increase of inhibitory activity was achieved by optimisation of aromatic substituents and conformational restriction.
authors.affiliation: Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland. jens-uwe.peters@roche.com
authors.forename: Jens-Uwe
authors.initials: JU
authors.lastname: Peters
authors.forename: Silja
authors.initials: S
authors.lastname: Weber
authors.forename: Stéphane
authors.initials: S
authors.lastname: Kritter
authors.forename: Peter
authors.initials: P
authors.lastname: Weiss
authors.forename: Angelina
authors.initials: A
authors.lastname: Wallier
authors.forename: Daniel
authors.initials: D
authors.lastname: Zimmerli
authors.forename: Markus
authors.initials: M
authors.lastname: Boehringer
authors.forename: Matthias
authors.initials: M
authors.lastname: Steger
authors.forename: Bernd-Michael
authors.initials: BM
authors.lastname: Loeffler
mesh_terms: D000588:Amines / Q000737:chemistry*; D002478:Cells, Cultured; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D018819:Dipeptidyl Peptidase 4 / Q000187:drug effects* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006841:Hydrocarbons, Aromatic / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D011725:Pyridines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D004791:Enzyme Inhibitors; D006841:Hydrocarbons, Aromatic; D011725:Pyridines; D018819:Dipeptidyl Peptidase 4