title: Genetic covariation of pelvic organ and elbow mobility in twins and their sisters.
abstract: A range of environmental risk factors, with childbirth the most notable, have been associated with the development of pelvic organ prolapse and urinary incontinence. However, indications of genetic influence (positive family histories, ethnic differences) have prompted research into the heritability of measures of pelvic organ descent and joint mobility, which have also been associated with prolapse and incontinence. Genes appear to influence about half of the variation in these measures and, furthermore, the pelvic organ measures are associated with elbow hyperextension at a phenotypic level (r approximately .2). We examined these measures in young, nulligravid women to determine if their association is due to a common genetic source. Data were collected from 178 Caucasian female co-twins and non-twin sisters, 50 of whom returned to be retested, which allowed reliability to be estimated and unreliable variance to be isolated in the multivariate analyses. Structural equation modeling was used to estimate genetic associations between latent elbow and bladder mobility factors for which heritabilities were estimated to be 0.80 and 0.64 respectively. The association between these factors appeared to be mediated by common genes (genetic r = .48, non-shared environmental r = -.06), with genes influencing latent elbow mobility accounting for 14% of the variation in latent bladder mobility. We speculate that genes influencing connective tissue structure may underlie this association.
authors.affiliation: Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. narelleH@qimr.edu.au
authors.forename: Narelle K
authors.initials: NK
authors.lastname: Hansell
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Dietz
authors.forename: Susan A
authors.initials: SA
authors.lastname: Treloar
authors.forename: Barton
authors.initials: B
authors.lastname: Clarke
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D004551:Elbow Joint / Q000502:physiology*; D005192:Family Health; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D016014:Linear Models; D015999:Multivariate Analysis; D010641:Phenotype; D035781:Siblings; D014427:Twins / Q000235:genetics / Q000502:physiology*; D014429:Twins, Dizygotic / Q000235:genetics / Q000502:physiology; D014430:Twins, Monozygotic / Q000235:genetics / Q000502:physiology; D001743:Urinary Bladder / Q000502:physiology*