Base-catalyzed inversion of chiral sulfur centers. A computational study.
[reaction: see text] A theoretical study on the pyramidal inversion of the chiral sulfur compounds SO(X)(Me) (X = Cl, OMe, p-MePh) has been carried out by means of the DFT(Becke3LYP) method. Our results reveal that in the case of X = Cl, an organic tertiary amine such as NMe(3) can catalyze the racemization. The base-catalyzed inversion of SO(Cl)(Me) is proposed as a feasible dynamic kinetic resolution mechanism for the synthesis of chiral sulfoxides by the DAG method.
Balcells
David
D
Institut Català d'Investigació Química, Av. Països Catalans s/n, 43007 Tarragona, Catalonia, Spain.
Maseras
Feliu
F
Khiar
Noureddine
N