title: Biochemical and histological responses in mussel (Mytilus edulis) exposed to North Sea oil and to a mixture of North Sea oil and alkylphenols.
abstract: Several environmental chemicals are suspected to be responsible for adverse health effects on the reproductive system in various organisms. During this work, environmentally relevant concentrations of North Sea oil were used alone or in combination with alkylphenols and additional PAH to study the effect on vitellogenin-like protein expression and gonadal development in mussels. North Sea oil (0.5 ppm) induced the expression of phospho-proteins in both sexes indicating that some compounds are oestrogen-mimics. This induction was not seen in samples dosed with the mixture but signs of toxic effects were observed in the gonads. Indeed, numerous degenerating ovarian follicles in females and foci, similar to vertebrate melanomacrophage centres, were observed in testes.
authors.affiliation: Environmental and Toxicological Chemistry LPTC, UMR CNRS 5472, University of Bordeaux I, Talence, France. n.aarab@lptc.u-bordeaux1.fr
authors.forename: N
authors.initials: N
authors.lastname: Aarab
authors.forename: C
authors.initials: C
authors.lastname: Minier
authors.forename: S
authors.initials: S
authors.lastname: Lemaire
authors.forename: E
authors.initials: E
authors.lastname: Unruh
authors.forename: P-D
authors.initials: PD
authors.lastname: Hansen
authors.forename: B K
authors.initials: BK
authors.lastname: Larsen
authors.forename: O-K
authors.initials: OK
authors.lastname: Andersen
authors.forename: J-F
authors.initials: JF
authors.lastname: Narbonne
mesh_terms: D000818:Animals; D049872:Bivalvia / Q000033:anatomy & histology / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006066:Gonads / Q000187:drug effects* / Q000473:pathology; D006652:Histological Techniques; D008297:Male; D009659:North Sea; D010578:Petroleum / Q000633:toxicity*; D010636:Phenols / Q000633:toxicity*; D010750:Phosphoproteins / Q000096:biosynthesis; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*
chemical_list: D010578:Petroleum; D010636:Phenols; D010750:Phosphoproteins; D011084:Polycyclic Aromatic Hydrocarbons