Demonstration of the osseoinductive effect of bone morphogenetic protein within endosseous dental implants.
The purpose of this case report was to demonstrate the host osseous response in the maxilla after placing bone morphogenetic protein (BMP) within a specially designed implant. Under normal circumstances, it is usually necessary to wait from 4 to 6 months, or even longer in some cases, for osseous integration. Our objective was to assess the ability of BMP, which was carried on an absorbable collagen sponge in horizontal portals of the subject im plant,to affect the formation of bone in a Macaca fascicularis monkey. A control implant was loaded internally with autogenous bone recovered from the preparation of the osteotomy. The results demonstrated that osseous peri-implant healing occurs using BMP in this format.
Boyne
Phillip
P
Department of Advanced Education, Oral and Maxillofacial Surgery, School of Dentistry, Loma Linda University, Loma Linda, California, USA.
Jones
Shedrick D
SD
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D020007:Implants, Experimental; D008252:Macaca fascicularis; D016348:Osseointegration / Q000187:drug effects*; D020390:Tooth Socket
D019485:Bone Morphogenetic Proteins; D015921:Dental Implants