title: Texture optimization of water-in-oil emulsions.
abstract: The aim of this research is to demonstrate the effect of variations in certain parameters of the oily phase (OP) in water-in-oil (W/O) emulsions on rheological and texture properties of finished products. The formulated emulsions were selected according to an optimal experimental procedure. The applied variations were nature of the OP, its volume fraction, the hydrophilic-lipophilic balance (HLB) value, and the surfactant proportion. Results are presented for the followed tests carried out on the emulsions: texture analysis, rheology, and particle size analysis. The oils used in the study were sweet almond oil, liquid paraffin, maize oil, cyclomethicone, dimethicone, and wheat germ oil. The resulting data demonstrate a notable influence of the volume fraction oil on hardness, viscosity, adhesiveness, and cohesiveness of W/O emulsions. Emulsion hardness and viscosity increased as the OP percentage increased; this effect being even more pronounced for the vegetable oils. In contrast, emulsion adhesiveness and cohesiveness decreased as the volume fraction oil increased. The HLB value of the surfactant mixture of the emulsion also influenced hardness, adhesiveness, and elasticity, increasing or decreasing as HLB value did.
authors.affiliation: Faculté de Pharmacie de Marseille, Laboratoire de Pharmacie Galénique et Industrielle, Marseille, France. v.aghazarian@caramail.com
authors.forename: V
authors.initials: V
authors.lastname: Lemaitre-Aghazarian
authors.forename: P
authors.initials: P
authors.lastname: Piccerelle
authors.forename: J P
authors.initials: JP
authors.lastname: Reynier
authors.forename: J
authors.initials: J
authors.lastname: Joachim
authors.forename: R
authors.initials: R
authors.lastname: Phan-Tan-Luu
authors.forename: M
authors.initials: M
authors.lastname: Sergent
mesh_terms: D004339:Drug Compounding / Q000379:methods; D004655:Emulsions / Q000737:chemistry*; D006244:Hardness; D009821:Oils / Q000737:chemistry*; D010316:Particle Size; D012212:Rheology; D014783:Viscosity; D014867:Water / Q000737:chemistry*
chemical_list: D004655:Emulsions; D009821:Oils; D014867:Water