Effect of a 50 Hz electric field on plasma ACTH, glucose, lactate, and pyruvate levels in stressed rats.
The effect of extremely low frequency electric field (EF) on stress induced changes of plasma ACTH, glucose, lactate, and pyruvate levels was examined in ovariectomized rats. The rats were exposed to 50 Hz EF (17500 V/m) for 60 min and were restrained for the latter half (30 min) of the EF exposure period. The restraint stress significantly increased the plasma ACTH and glucose levels (P <.05: Student's t test). Restraint induced increase of plasma ACTH and glucose levels tended to be suppressed by exposure to the EF. Meanwhile, the EF exposure also affected plasma lactate level. Thus, the EF exposure significantly decreases plasma lactate levels in the stressed rats (P <.05: Student's t test). Although the precise mechanisms in the restraint dependent alteration in plasma ACTH, glucose, lactate, and pyruvate levels are not fully understood, our results demonstrate that the 50 Hz EF alter both stress responses and energy metabolism in stressed rats.
Harakawa
Shinji
S
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan. harakawa@bd5.so-net.ne.jp
Takahashi
Ikuo
I
Doge
Fuyuki
F
Martin
David E
DE
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000187:drug effects / Q000528:radiation effects*; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000528:radiation effects*; D003975:Diazepam / Q000008:administration & dosage; D004574:Electromagnetic Fields; D004734:Energy Metabolism / Q000528:radiation effects; D005260:Female; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D019344:Lactic Acid / Q000097:blood / Q000528:radiation effects*; D010052:Ovariectomy; D011773:Pyruvates / Q000097:blood / Q000528:radiation effects*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000097:blood* / Q000503:physiopathology
D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D011773:Pyruvates; D019344:Lactic Acid; D000324:Adrenocorticotropic Hormone; D003975:Diazepam