title: [Radiosurgery of vestibular schwannomas after microsurgery and combined radio-microsurgery].
abstract: Significant morbidity is expected after microsurgery for recurrent or growing residual vestibular schwannoma (VS). In order to avoid this procedure, radiosurgery appeared as an interesting alternative. The purpose of this study is to analyze the results of Gamma Knife radiosurgery in this indication. Between July 1992 and January 2002, 60 patients (including 12 NF2 patients) underwent radiosurgical treatment after one or more attempts of surgical resection (including 27 growing remnant VS and 19 recurrent VS) and could be followed with enough informations, out of 103 patients (10% of the VS population treated during the same period). Mean interval between surgical removal and radiosurgery was 71.5 Months (1.8-127.8 Months). Technical difficulties during the procedure were observed in the 12 cases, mainly due to problems in identifying the target. Median follow-up was 51.6 Months. Four out of 58 patients (7%, confidence interval: 1.9-16.7) were diagnosed as failure. Statistical study failed to find significant parameters influencing failure. Facial and trigeminal nerves were not impaired while one case of severe bulbopontine radio-induced injury leading to a lower cranial nerve deficit was observed. These results show that, in spite of additional difficulties to treat these patients with radiosurgery, this treatment is efficient with acceptable morbidity and can avoid another microsurgical procedure. The strategy of planned combined micro-and radiosurgical treatment of large VS deserves additional investigations to be validated.
authors.affiliation: Service de Neurochirurgie, Hôpital Sainte-Marguerite, AP-HM, Marseille. proche@mail.ap-hm.fr
authors.forename: P-H
authors.initials: PH
authors.lastname: Roche
authors.forename: S
authors.initials: S
authors.lastname: Robitail
authors.forename: C
authors.initials: C
authors.lastname: Delsanti
authors.forename: R
authors.initials: R
authors.lastname: Marouf
authors.forename: W
authors.initials: W
authors.lastname: Pellet
authors.forename: J
authors.initials: J
authors.lastname: Régis
mesh_terms: D000328:Adult; D000368:Aged; D004428:Ear Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D019569:Hemifacial Spasm / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D016518:Neurofibromatosis 2 / Q000453:epidemiology; D009464:Neuroma, Acoustic / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D011184:Postoperative Period; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods*; D016879:Salvage Therapy / Q000706:statistics & numerical data