Oleamide and anandamide effects on food intake and sexual behavior of rats.
Oleamide is a lipid with diverse properties, including cannabinoid-like activity. For example, it induces the classic triad of effects attributable to these molecules: decrease in core temperature, hypolocomotion, and reduction in pain perception. However, as it binds to the cannabinoid receptors (CB1) only at high concentrations, it is not considered an actual endocannabinoid. In this study, we tested the effect of oleamide on food intake and sexual behavior and compared it to the effect induced by anandamide. Results indicate that oleamide and anandamide increased food intake during the 3h post-injection. In addition, anandamide but not oleamide induced changes in sexual performance. This study further supports the role of endocannabinoids in food ingestion and male sexual behavior and gives additional support to the notion that, although oleamide might not be an endocannabinoid, it shares some effects with them.
Martínez-González
Dolores
D
Grupo de Neurociencias, Depto. de Fisiología, Fac. de Medicina, Universidad Nacional Autónoma de, Mexico, D.F., Mexico. opg@servidor.unam.mx
Bonilla-Jaime
Herlinda
H
Morales-Otal
Adriana
A
Henriksen
Steven J
SJ
Velázquez-Moctezuma
Javier
J
Prospéro-García
Oscar
O
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D063388:Endocannabinoids; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D009829:Oleic Acids / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D051381:Rats; D017208:Rats, Wistar; D012725:Sexual Behavior / Q000187:drug effects*
D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D006993:Hypnotics and Sedatives; D009829:Oleic Acids; D053284:Polyunsaturated Alkamides; C029407:oleylamide; C078814:anandamide