Ubiquitin ligases in T cell activation and autoimmunity.
Ubiquitination-mediated protein modifications are increasingly recognized as key regulatory events in many basic cell biology processes. A key class of enzymes called ubiquitin ligases, which has been shown to play a crucial role in the ubiquitination process, can positively or negatively regulate T cell responses. This review summarizes the recent advances defining the roles of several ubiquitin ligases in T cell activation and autoimmunity.
Zhang
Jian
J
Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA. jian_zhang@rush.edu
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000201:enzymology*; D044767:Ubiquitin-Protein Ligases / Q000276:immunology*
D044767:Ubiquitin-Protein Ligases