title: Reactions of TFDA with ketones. synthesis of difluoromethyl 2,2-difluorocyclopropyl ethers.
abstract: The sequential reaction of 2 equiv of difluorocarbene (generated from trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) by treatment with catalytic fluoride ion) with a series of electron-rich aromatic ketones and alpha,beta-unsaturated ketones leads to the formation of difluoromethyl 2,2-difluorocyclopropyl ethers in good yield.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Cai
authors.forename: Yian
authors.initials: Y
authors.lastname: Zhai
authors.forename: Ion
authors.initials: I
authors.lastname: Ghiviriga
authors.forename: Khalil A
authors.initials: KA
authors.lastname: Abboud
authors.forename: William R
authors.initials: WR
authors.lastname: Dolbier