[Study on antitumor activities of ginkgolic acids from Ginkgo sarcotestas in vitro].
OBJECTIVE
To study the influence of ginkgolic acids on human tumor cells and normal cells.


METHODS
Ginkgolic acids (total concentration 90%) was prepared from ginkgo sarcotestas. The inhibitive effect of ginkgolic acids on human tumor cells and normal cells lines was examined by MTT assay.


RESULTS
When the concentration was 5.0 micrograms/ml, ginkgolic acids obviously inhibited the growth of tumor cells and didn't influence the normal cells. Inhibitive rate of ginkgolic acids on LTEP-a-2 was 59.1%. High-concentration ginkgolic acids had inhibitive effect on the growth of tumor cells and normal cells.


CONCLUSIONS
Ginkgolic acids had a obvious inhibitive effect on tumor cells in vitro. When the concentration was under 5.0 micrograms/ml, ginkgolic acids didn't influence the growth of normal cells.
Yang
Xiaoming
X
Jiangsu University, Zhenjiang 212013.
Qian
Zhiyu
Z
Chen
Jun
J
Zhu
Wei
W
Xie
Jimin
J
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D020441:Ginkgo biloba / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D051379:Mice; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D012459:Salicylates / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012459:Salicylates; C112485:ginkgolic acid