title: The effect of curcumin on cadmium-induced oxidative damage and trace elements level in the liver of rats and mice.
abstract: The present study was designed to investigate in acute animal experiments the effects of oral curcumin pre-treatment (50 mg/kg body weight per day for 3 days) on liver oxidative damage and trace element changes caused by cadmium chloride administration (0.025 mmol/kg to rats and 0.03 mmol/kg to mice, s.c., 1h after the last curcumin treatment). In rats, the level of Cd-induced lipid peroxidation (320% of controls) was significantly lowered by curcumin pre-treatment (165% of controls), and was accompanied by significant increase of glutathione (GSH) level in both Cd-treated and Cd plus curcumin-treated group. In mice, the Cd-induced lipid peroxidation (125% of controls) was abolished by curcumin treatment. Concurrently, a depletion of GSH was found in the liver of both Cd-treated (67% of controls) and Cd plus curcumin-treated mice (54% of controls). Curcumin treatment did not change cadmium (Cd) distribution and did not cause systematic alterations in trace element status.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University in Prague, Karlovarská 48, 301 66 Pilsen, Czech Republic. vladislav.eybl@lfp.cuni.cz
authors.forename: Vladislav
authors.initials: V
authors.lastname: Eybl
authors.forename: Dana
authors.initials: D
authors.lastname: Kotyzová
authors.forename: Monika
authors.initials: M
authors.lastname: Bludovská
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002104:Cadmium / Q000633:toxicity*; D003474:Curcumin / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D014131:Trace Elements / Q000378:metabolism
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D014131:Trace Elements; D002104:Cadmium; D005978:Glutathione; D003474:Curcumin