title: Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment.
abstract: The dinuclear platinum complex trans-[[Pt(NH(3))(2)Cl](2)micro-dpzm](2+)(di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.
authors.affiliation: School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Australian Defence Force Academy, Northcott Drive, Campbell, ACT, 2600, Australia.
authors.forename: Nial J
authors.initials: NJ
authors.lastname: Wheate
authors.forename: Anthony I
authors.initials: AI
authors.lastname: Day
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Blanch
authors.forename: Alan P
authors.initials: AP
authors.lastname: Arnold
authors.forename: Carleen
authors.initials: C
authors.lastname: Cullinane
authors.forename: J Grant
authors.initials: JG
authors.lastname: Collins
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D007938:Leukemia / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D014407:Tumor Cells, Cultured; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D004273:DNA, Neoplasm; D007093:Imidazoles; D009944:Organoplatinum Compounds; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils