title: [Secondary diseases in patients with HIV infection: 15-year follow-up].
abstract: OBJECTIVE
  To analyse the results of a 15-year study of opportunistic diseases in AIDS patients.
  
  
  METHODS
  The spectrum of opportunistic diseases were made in AIDS patients in respect to clinical, laboratory and autopsy data for the periods: 1987-1992 (n = 27, 25 deaths--92.6%), 1993-1997 (n = 95, 58 deaths--61.8%), 1998-1999 (n = 70, 28 deaths--40%), 2000-2001 (n = 126, 31 deaths--24.6%), 2002 (n = 80, 32 deaths--40%).
  
  
  RESULTS
  The spectrum of opportunistic diseases in AIDS patients was determined for the above time periods and causes underlying these diseases have been determined.
  
  
  CONCLUSIONS
  Among opportunistic diseases associated with HIV infections most prevalent were the following: tuberculosis, cytomegaloviral infections, cerebral toxoplasmosis. Leading modern trends were identified: increasing morbidity of AIDS, tuberculosis, new AIDS cases at late stages with severe opportunistic diseases (2/3 of deaths).
authors.forename: T N
authors.initials: TN
authors.lastname: Ermak
authors.forename: A V
authors.initials: AV
authors.lastname: Kravchenko
authors.forename: B M
authors.initials: BM
authors.lastname: Gruzdev
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000453:epidemiology / Q000401:mortality*; D001927:Brain Diseases / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D005260:Female; D015497:HIV-1; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000453:epidemiology / Q000209:etiology / Q000401:mortality / Q000473:pathology; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology; D016781:Toxoplasmosis, Cerebral / Q000453:epidemiology / Q000209:etiology / Q000401:mortality*; D014376:Tuberculosis / Q000453:epidemiology / Q000209:etiology / Q000401:mortality* / Q000473:pathology