0.2 T magnetic field inhibits angiogenesis in chick embryo chorioallantoic membrane.
Inhibition of angiogenesis is a major target in the fight against cancer and other diseases. Although the effects of static magnetic fields on cancer development and cell growth have been investigated, effects on angiogenesis have received no attention so far. In this study we report the effects on angiogenesis of exposure to 0.2 T static magnetic field. Angiogenesis was analyzed using the chick embryo chorioallantoic membrane assay. Exposure to 0.2 T static magnetic field was achieved by placing the eggs for 3 hr in the isocentre of the magnet of a sectorial magnetic resonance tomograph used in clinical practice. In sham exposed specimens treated with phosphate buffered saline (negative control), no significant vascular reaction was detectable; 3 hr exposure to 0.2 T static magnetic field did not affect the basal pattern of vascularization or chick embryo viability. Prostaglandin E1 and fetal calf serum elicited a strong angiogenic response in sham exposed eggs. This angiogenic response was significantly inhibited by 3 hr exposure to 0.2 T static magnetic field. These findings point to possible use of static magnetic field in inhibiting angiogenesis; this effect could be exploited for treatment of cancer and other diseases where excessive angiogenesis is involved.
Ruggiero
Marco
M
Department of Experimental Pathology and Oncology, University of Firenze, Firenze, Italy. biolmol@yahoo.com
Bottaro
Donald P
DP
Liguri
Gianfranco
G
Gulisano
Massimo
M
Peruzzi
Benedetta
B
Pacini
Stefania
S
D000482:Allantois / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D000527:Alprostadil / Q000494:pharmacology; D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects; D005312:Fetal Blood; D008280:Magnetics; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000528:radiation effects*; D011829:Radiation Dosage; D013997:Time Factors
D043925:Angiogenesis Inducing Agents; D000527:Alprostadil