title: Familial monozygotic twinning: report of an extended multi-generation family.
abstract: Thirteen sets of monozygotic (MZ) twins from an extended multi-generation family are reported. Zygosity was determined by interviewing families for overall physical similarity and by assessment of facial photographs. A hypothetical gene was traced back five generations to a common grandfather. Familial monozygotic twinning in this pedigree is compatible with autosomal dominant inheritance with reduced penetrance. Other plausible mechanisms of inheritance are discussed.
authors.affiliation: National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan.
authors.forename: Hanan A
authors.initials: HA
authors.lastname: Hamamy
authors.forename: Heitham K
authors.initials: HK
authors.lastname: Ajlouni
authors.forename: Kamel M
authors.initials: KM
authors.lastname: Ajlouni
mesh_terms: D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D011795:Surveys and Questionnaires; D014430:Twins, Monozygotic / Q000235:genetics