Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response.
DNA damage that is not properly repaired during genomic replication is a major source of gross chromosomal rearrangements and sequence loss during cell proliferation. In higher eukaryotes such mutations increase the risk of cancer. Eukaryotic cells have multiple checkpoint responses activated by DNA damage and stalled replication forks. We focus here on fork-associated events that activate and respond to S-phase checkpoint kinases.
Cobb
Jennifer A
JA
Department of Molecular Biology and the NCCR Frontiers in Genetics, University of Geneva, Quai Ernest-Ansermet 30, CH-1211 Geneva 4, Switzerland.
Shimada
Kenji
K
Gasser
Susan M
SM
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D008938:Mitosis; D011995:Recombination, Genetic; D016196:S Phase / Q000235:genetics*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism