title: Limited macular translocation: a clinicopathologic case report.
abstract: OBJECTIVE
  To illustrate the histopathologic findings in a patient who underwent limited macular translocation.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  The patient underwent limited macular translocation for subfoveal choroidal neovascularization resulting from age-related macular degeneration. Thirty-one months after surgery, the patient had died and both eyes were obtained at autopsy. Serial sections through both maculas were obtained. Immunohistochemistry of the foveas with C10C10 and hCAR/LUMIf antibodies for rods and cones, respectively, was performed.
  
  
  METHODS
  Histopathologic changes in the operated eye as compared with the fellow eye.
  
  
  RESULTS
  There was no morphologic difference in the subfoveal retinal pigment epithelium, Bruch's membrane, or choriocapillaris, but there was a decreased cone density in the translocated fovea as compared with the fellow eye.
  
  
  CONCLUSIONS
  In this patient, the fovea was translocated without causing apparent change in the underlying retinal pigment epithelium, Bruch's membrane, or choriocapillaris. Although there may be some photoreceptor loss, the excellent visual recovery suggests that the retinal pigment epithelium underlying the translocated fovea is functionally adequate.
authors.affiliation: Doheny Eye Institute, University of Southern California, Los Angeles, California, USA.
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Albini
authors.forename: Narsing A
authors.initials: NA
authors.lastname: Rao
authors.forename: Aimin
authors.initials: A
authors.lastname: Li
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Craft
authors.forename: Gildo Y
authors.initials: GY
authors.lastname: Fujii
authors.forename: Eugene
authors.initials: E
authors.lastname: De Juan
mesh_terms: D000368:Aged; D019393:Arrestin / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis; D016570:Bruch Membrane / Q000473:pathology*; D002452:Cell Count; D002829:Choroid / Q000098:blood supply; D020256:Choroidal Neovascularization / Q000209:etiology / Q000473:pathology / Q000601:surgery; D005451:Fluorescein Angiography; D006801:Humans; D007124:Immunoenzyme Techniques; D008266:Macula Lutea / Q000473:pathology* / Q000637:transplantation*; D008268:Macular Degeneration / Q000150:complications / Q000473:pathology / Q000601:surgery; D008297:Male; D020419:Photoreceptor Cells, Vertebrate / Q000378:metabolism / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000473:pathology*
chemical_list: D019393:Arrestin; D015415:Biomarkers