title: Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin.
abstract: A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano[3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM.
authors.affiliation: Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan.
authors.forename: Akitsu
authors.initials: A
authors.lastname: Ogawa
authors.forename: Chikako
authors.initials: C
authors.lastname: Murakami
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamisuki
authors.forename: Isoko
authors.initials: I
authors.lastname: Kuriyama
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Fumio
authors.initials: F
authors.lastname: Sugawara
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mizushina
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056890:Eukaryota / Q000382:microbiology*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D008297:Male; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002839:Chromans; C495736:pseudodeflectusin; D005978:Glutathione