Antifungal cyclopentenediones from Piper coruscans.
Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and may serve as a template for a new class of antifungal agents.
Li
Xing-Cong
XC
National Center for Natural Products Research, Mississippi, USA. xcli7@olemiss.edu
Ferreira
Daneel
D
Jacob
Melissa R
MR
Zhang
Qifeng
Q
Khan
Shabana I
SI
ElSohly
Hala N
HN
Nagle
Dale G
DG
Smillie
Troy J
TJ
Khan
Ikhlas A
IA
Walker
Larry A
LA
Clark
Alice M
AM
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*
D000935:Antifungal Agents; D003517:Cyclopentanes; C013905:cyclopentenone