In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor beta and E-cadherin expression but decrease transforming growth factor beta1.
In mice fed a diet supplemented with red clover isoflavones the prostatic epithelium displays a significant increase in the production of estrogen receptor beta and the adhesion protein E-cadherin but a decrease in transforming growth factor beta1. These proteins are estrogenically-induced markers of proliferation, maintenance of histological architecture, preservation of cell phenotype and reduction of the potential for neoplastic and metastatic transformation. This study suggests that red clover isoflavones represent a non-toxic dietary treatment for prostatic hyperplasia and a reduction in the potential for neoplastic transformation.
Slater
M
M
Institute for Biomedical Research, The University of Sydney, Australia. michaels@anatomy.usyd.edu.au
Brown
D
D
Husband
A
A
D000821:Animal Feed; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D004032:Diet; D004848:Epithelium / Q000378:metabolism; D047629:Estrogen Receptor beta; D015870:Gene Expression / Q000187:drug effects; D007150:Immunohistochemistry; D007529:Isoflavones / Q000008:administration & dosage*; D008297:Male; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011960:Receptors, Estrogen / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D053773:Transforming Growth Factor beta1; D029921:Trifolium / Q000737:chemistry*; D015854:Up-Regulation
D015820:Cadherins; D047629:Estrogen Receptor beta; D007529:Isoflavones; D011960:Receptors, Estrogen; C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1