title: Antioxidant activity of three extracts of Morus nigra.
abstract: The antioxidant effect of three different extracts of Morus nigra fruit (fruit juice, hydroalcoholic and polyphenolic) on haemoglobin glycosylation, peroxidative damage to human erythrocytes, liver hepatooytes of rats and human low-density lipoprotein (LDL) were studied. The results show that all three extracts inhibited haemoglobin glycosylation induced by glucose to differing degrees. The haemolysis of human erythrocytes induced by hydrogen peroxide was also inhibited. The production of malondialdehyde (MDA) during peroxidative damage to plasma membranes of isolated rat hepatocytes induced by tert-butyl hydroperoxide (tBH) was also inhibited. Inhibition of lipid peroxidation of LDL induced by copper (II) ion was achieved during the study. The results suggest that Morus nigra fruit has a protective action against peroxidative damage to biomembranes and biomolecules.
authors.affiliation: Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. crc@mui.ac.ir
authors.forename: Gholam Ali
authors.initials: GA
authors.lastname: Naderi
authors.forename: Seddigheh
authors.initials: S
authors.lastname: Asgary
authors.forename: Nizal
authors.initials: N
authors.lastname: Sarraf-Zadegan
authors.forename: Heshmatallah
authors.initials: H
authors.lastname: Oroojy
authors.forename: Farsad
authors.initials: F
authors.lastname: Afshin-Nia
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008078:Cholesterol, LDL / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects; D005638:Fruit; D006461:Hemolysis / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D029586:Moraceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D020122:tert-Butylhydroperoxide
chemical_list: D000975:Antioxidants; D008078:Cholesterol, LDL; D010936:Plant Extracts; D008315:Malondialdehyde; D020122:tert-Butylhydroperoxide; D006861:Hydrogen Peroxide