title: A new route to aristocularine alkaloids: total synthesis of aristoyagonine.
abstract: A short and efficient synthesis of aristocularines, involving the sequential construction of phosphorylated 4-alkoxyisoindolinones, Horner-type reaction, and ultimate cyclization by diaryl ether coupling, is disclosed. The success of this new conceptual approach is demonstrated by the total synthesis of the aristocularine alkaloid aristoyagonine.
authors.affiliation: Laboratoire de Chimie Organique Physique, UMR 8009 "Chimie Organique et Macromoléculaire", Université des Sciences et Technologies de Lille, Bâtiment C3(2), F-59655 Villeneuve d'Ascq Cedex, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Moreau
authors.forename: Axel
authors.initials: A
authors.lastname: Couture
authors.forename: Eric
authors.initials: E
authors.lastname: Deniau
authors.forename: Pierre
authors.initials: P
authors.lastname: Grandclaudon
mesh_terms: D003500:Cyclization; D031310:Fumarioideae / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D007546:Isoquinolines; C499203:aristocularine; C499202:aristoyagonine