[Study of the mechanism of action of novel fluoro-containing analogs of diazoxide on the vascular tonus].
On the isolated preparations of rat aorta it was shown that the new fluoro-containing analogues of diazoxide (DiazoFp and DiazoFm) elicit vasodilatatory effects related to the activation of ATP-sensitive potassium channels. It was established that DiazoFp is a more powerful vasodilator than DiazoFm and diazoxide. It was proposed that DiazoFp action consists of two components: direct activation of sarcKATP channels and activation of sarcKATP channels, through activation of mitoKATP channels.
Pyvovar
S M
SM
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Strutyns'kyĭ
R B
RB
Iagupol's'kyĭ
L M
LM
Moĭbenko
O O
OO
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D003981:Diazoxide / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006845:Hydrocarbons, Fluorinated / Q000494:pharmacology*; D066298:In Vitro Techniques; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism; D051381:Rats; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D006845:Hydrocarbons, Fluorinated; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate; D003981:Diazoxide