title: Is post-systolic motion the optimal ultrasound parameter to detect induced ischaemia during dobutamine stress echocardiography?
abstract: OBJECTIVE
  Doppler myocardial imaging (DMI) has been suggested as a method of quantifying induced ischaemia during dobutamine stress echocardiography (DSE). The aim of the present study was to investigate both standard systolic and diastolic parameters, but more specifically to address the phenomenon of post-systolic motion (PSM) as a marker of acquired ischaemia during DSE using pulsed-wave DMI.
  
  
  RESULTS
  We examined 60 patients without previous myocardial infarction who underwent DSE. Peak systolic, post-systolic, early and late diastolic velocities were measured at rest and during stress. Myocardial segments (n = 908) were divided into ISCHAEMIC and NON-ISCHAEMIC groups according to the presence of significant angiographic coronary stenosis. ISCHAEMIC segments (n = 357) compared with NON-ISCHAEMIC segments (n = 551) demonstrated a reduced increase of systolic velocity (8.0-12.7 vs 9.3-16.4 cm/s, P < 0.05), prominent PSM (5.8-8.3 vs 0.63-2.1 cm/s, P < 0.000001) and reduced early diastolic velocity (6.5-10.2 vs 7.9-13.2 cm/s, P < 0.04) during stress. The peak velocity of PSM was the most accurate index of induced ischaemia (sensitivity 73-100%, specificity 82-97%) compared to systolic and early diastolic velocities (sensitivity 52-77% and 63-68%, specificity 63-77% and 59-81%, respectively).
  
  
  CONCLUSIONS
  PSM derived by pulsed-wave DMI during DSE was the most sensitive index of acquired ischaemia compared to other functional DMI indices.
authors.affiliation: Cardiovascular Centre, Vilnius University Hospital, Santariskiu Klinikos, Vilnius, Lithuania. jelena.celutkiene@santa.lt
authors.forename: Jelena
authors.initials: J
authors.lastname: Celutkiene
authors.forename: George R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: Aleksandras
authors.initials: A
authors.lastname: Laucevicius
authors.forename: Diana
authors.initials: D
authors.lastname: Zakarkaite
authors.forename: Alfredas
authors.initials: A
authors.lastname: Rudys
authors.forename: Virginija
authors.initials: V
authors.lastname: Grabauskiene
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D015150:Echocardiography, Doppler / Q000592:standards; D025401:Echocardiography, Stress / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011446:Prospective Studies; D012680:Sensitivity and Specificity