title: Ovarian cancer in Ibadan: characteristics and management.
abstract: Ovarian cancer has the highest case fatality rate among gynaecological cancers worldwide because of lack of effective screening methods and non-specific early warning symptoms with late presentation. A reinvigorated study is necessary in the developing countries because of a projected increase in its incidence. The decreasing fertility rate and increasing use of ovulation induction drugs are some of the reasons. The Ovarian Cancer Service of the Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Oyo State, Nigeria commenced the first longitudinal study of this malignancy from 1 December 1998 in order to establish a regional management and research centre. It is a questionnaire survey detailing the demography, clinical and staging laparotomy findings and histology of all confirmed cases. Twenty-one staging laparotomy and histologically confirmed ovarian cancer cases were managed from 1 December 1998 to 31 July 2002, about 1.5% of the 1387 gynaecological admissions. It is the third most common of the gynaecological cancers, representing 9.8% of the 214 cases. More than 60% of the patients were 50 years or younger. Only 19% were nulliparous, with 47.6% having had five or more deliveries. Only two patients (9.5%) had used the oral contraceptive pill, for a maximum period of 1 month. Only one patient (4.8%) had a positive family history of cancer. Abdominal swelling was the most common presenting symptom. Eighty-one per cent of the patients presented in Stages III and IV. Epithelial ovarian cancer constituted about 76.2% of the cases. Only 23.8% had adjuvant therapy, consisting of combination chemotherapy using cisplatin-based regimes. The case fatality rate 6 months after surgery was 76%. The ovarian cancer patients in this environment are younger and of higher parity than expected. The risk factors for this disease require further study.
authors.affiliation: Department of Obstetrics and Gynaecology, College of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria. akin_tundeodukogbe@yahoo.com
authors.forename: A A
authors.initials: AA
authors.lastname: Odukogbe
authors.forename: C A
authors.initials: CA
authors.lastname: Adebamowo
authors.forename: B
authors.initials: B
authors.lastname: Ola
authors.forename: O
authors.initials: O
authors.lastname: Olayemi
authors.forename: A
authors.initials: A
authors.lastname: Oladokun
authors.forename: I F
authors.initials: IF
authors.lastname: Adewole
authors.forename: O A
authors.initials: OA
authors.lastname: Omigbodun
authors.forename: C O
authors.initials: CO
authors.lastname: Aimakhu
authors.forename: M A
authors.initials: MA
authors.lastname: Okunlola
authors.forename: O
authors.initials: O
authors.lastname: Fakulujo
authors.forename: F A
authors.initials: FA
authors.lastname: Oluyemi
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000628:therapy; D012959:Socioeconomic Factors