Recombinant erythropoietin as a neuroprotective treatment: in vitro and in vivo models.
The biologic effects of erythropoietin in the central and peripheral nervous system involve the activation of its specific cell surface receptor and corresponding signal transduction pathways. This article reviews the neuroprotective effects of erythropoietin in brain, emphasizing the progress made using in vitro and in vivo research models.
Juul
Sandra
S
Division of Neonatology, Department of Pediatrics, University of Washington, PO Box 356320, Seattle, WA 98195, USA. sjuul@u.washington.edu
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004921:Erythropoietin / Q000494:pharmacology* / Q000627:therapeutic use; D005727:Ganglia, Spinal / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D009359:Neonatology / Q000379:methods; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017467:Receptors, Erythropoietin / Q000378:metabolism; D011994:Recombinant Proteins; D012160:Retina / Q000187:drug effects
D018696:Neuroprotective Agents; D017467:Receptors, Erythropoietin; D011994:Recombinant Proteins; D004921:Erythropoietin