title: WT1 gene expression: useful marker for minimal residual disease in childhood myelodysplastic syndromes and juvenile myelo-monocytic leukemia?
abstract: The WT1 gene is considered to be highly expressed in patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia and chronic myeloid leukemia and is thought to play a key role in maintaining the viability of leukemia cells. However, little is known about the WT1 gene expression levels in pediatric patients with juvenile myelo-monocytic leukemia (JMML) and myelodysplastic syndromes (MDS). We studied WT1 expression in diagnostic bone marrow (BM) and peripheral blood (PB) samples of 90 patients with JMML, low grade MDS, advanced MDS and myelodysplasia-related AML in BM (n = 20) and PB (n = 18) samples of normal healthy volunteer donors.
authors.affiliation: University Children's Hospital Tübingen, Germany. peter.bader@med.uni-tuebingen.de
authors.forename: Peter
authors.initials: P
authors.lastname: Bader
authors.forename: Charlotte
authors.initials: C
authors.lastname: Niemeyer
authors.forename: Gerrit
authors.initials: G
authors.lastname: Weber
authors.forename: Tiziana
authors.initials: T
authors.lastname: Coliva
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rossi
authors.forename: Hermann
authors.initials: H
authors.lastname: Kreyenberg
authors.forename: Anja
authors.initials: A
authors.lastname: Gerecke
authors.forename: Andrea
authors.initials: A
authors.lastname: Biondi
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001853:Bone Marrow / Q000737:chemistry; D002648:Child; D015870:Gene Expression; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis; D015479:Leukemia, Myelomonocytic, Acute / Q000175:diagnosis*; D009190:Myelodysplastic Syndromes / Q000175:diagnosis*; D018365:Neoplasm, Residual; D012333:RNA, Messenger / Q000032:analysis / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D025721:WT1 Proteins / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D025721:WT1 Proteins