title: Supplementation of wheat fibre can improve risk profile in patients with dysmetabolic cardiovascular syndrome.
abstract: OBJECTIVE
  We explored the effects of regular consumption of wheat fibre in patients with dysmetabolic cardiovascular syndrome (MCVS).
  
  
  METHODS
  Forty-two patients with MCVS (mean age 49+/-8 years) were randomly assigned to a treated group (n=21) or to a control group (n=21). Patients in the treated group ate 10.5 g of wheat fibre powder per day for the first week, followed by 21 g per day for the next 4 weeks. A standard high-fibre diet was recommended to both groups. Blood pressure, metabolic parameters, fibrinolytic parameters and factor VII activity were measured at entry and after 5 and 9 weeks.
  
  
  RESULTS
  After completing treatment, patients from both groups lost an average of 1 kg weight. Consumption of wheat fibre resulted in a significant (P<0.05) decrease of systolic and diastolic blood pressure, fasting glucose, glucose 2 h after oral glucose challenge (OGC), total cholesterol, low-density and high-density lipoprotein cholesterol, ranging from 7% to 18%. Furthermore, no significant reductions in fasting insulin, insulin 1 and 2 h after OGC, and glucose 1 h after OGC were found, whereas no differences in fibrinolytic parameters and factor VII activity were observed. Almost all beneficial effects of wheat fibre diminished 4 weeks after its withdrawal. In the non-treated group only a significant decrease of systolic pressure was observed.
  
  
  CONCLUSIONS
  Our results suggest that supplementation of wheat fibre, not just a standard high-fibre diet, may improve cardiovascular risk profile in patients with MCVS, in a manner independent of weight reduction.
authors.affiliation: Department for Vascular Diseases, Internal Clinic, University Clinical Centre, Ljubljana, Slovenia. miso.sabovicx@trnovo.kclj.si
authors.forename: Miso
authors.initials: M
authors.lastname: Sabovic
authors.forename: Simona
authors.initials: S
authors.lastname: Lavre
authors.forename: Irena
authors.initials: I
authors.lastname: Keber
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004043:Dietary Fiber / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000178:diet therapy*; D008875:Middle Aged; D011134:Polysaccharides / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D004043:Dietary Fiber; D011134:Polysaccharides; C076644:Trifyba; D014280:Triglycerides; D002784:Cholesterol