Bioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juice.
Pharmacokinetic parameters and the bioavailability of several dietary anthocyanins following consumption of blackcurrant juice and elderberry extract were compared exploratorily in 6 healthy volunteers. They were given a single oral dose of either 137 ml of blackcurrant juice (144.8 mg total anthocyanins) or 30 ml of elderberry extract (147.3 mg total anthocyanins). Within 7 hours, the urinary excretion of total anthocyanins (i.e. the sum of all assayed anthocyanidin glycosides) was 0.04% and 0.37% of the administered dose following blackcurrant juice and elderberry extract ingestion, respectively. Pharmacokinetic parameters based on non-compartmental methods for plasma and urine concentrations exhibited higher variability in urinary excretion after ingestion of elderberry extract. Anthocyanin absorption was significantly greater following the intake of elderberry extract than after the intake of blackcurrant juice as shown by the 5.3- and 6.2-fold higher estimates of dose-normalized Cmax and AUC(0-tZ) of total anthocyanins, respectively. The geometric means of t(1/2) were not significantly different following elderberry extract (1.74 h) and blackcurrant juice ingestion (1.73 h, p > 0.05). The urinary excretion rate of intact anthocyanins was fast, appeared to be monoexponential for both blackcurrant juice and elderberry extract. However, in order to evaluate the contribution of anthocyanins to the health-protecting effects of blackcurrant juice and elderberry extract it will be necessary to perform further studies on the unchanged glycosides and their in vivo metabolites in human plasma and urine.
Bitsch
I
I
Institute of Nutrition, Justus Liebig University, Giessen, Germany.
Janssen
M
M
Netzel
M
M
Strass
G
G
Frank
T
T
D000328:Adult; D000872:Anthocyanins / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D019540:Area Under Curve; D001628:Beverages; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D010936:Plant Extracts / Q000737:chemistry
D000872:Anthocyanins; D010936:Plant Extracts