Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis.
Migraine is a neurovascular syndrome characterized by recurrent headache associated with other symptoms, eventually preceded by aura. This chapter reviews the involvement of some mineral, coenzyme, and vitamin defects in the pathogenesis of migraine headaches and focuses on their potential therapeutic use in the preventive treatment for migraine. The therapeutic potential of magnesium, coenzyme Q(10), riboflavin, and vitamin B(12) can be cautiously inferred from some published open clinical trials; it should, however, be considered that double-blind randomized larger studies are needed to correctly estimate the impact of the placebo effect in these promising therapies.
Bianchi
Alfredo
A
Department of Pharmaceutical Sciences, University of Salerno, 84084 Fisciano, Italy.
Salomone
Salvatore
S
Caraci
Filippo
F
Pizza
Vincenzo
V
Bernardini
Renato
R
D'Amato
Cesare Colucci
CC
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D003067:Coenzymes; D005260:Female; D006710:Homocysteine / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008274:Magnesium / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008881:Migraine Disorders / Q000517:prevention & control*; D012256:Riboflavin / Q000494:pharmacology* / Q000627:therapeutic use; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D003067:Coenzymes; D006710:Homocysteine; D014451:Ubiquinone; C024989:coenzyme Q10; D008274:Magnesium; D014805:Vitamin B 12; D012256:Riboflavin