Hepatoprotective effect of New Livfit, a polyherbal formulation, is mediated through its free radical scavenging activity.
The effect of New Livfit, a polyherbal formulation, was studied on pyrogallol-induced hepatotoxicity in rats. Administration of pyrogallol 100 mg/kg, i.p. caused a significant increase in liver enzymes as well as a significant increase in lipid peroxidation. Simultaneous administration of oral New Livfit and pyrogallol prevented these changes in hepatic damage. The results of the study showed that New Liv fi t(R) exerted a hepatoprotective effect against pyrogallol induced liver toxicity, which was mediated through its free radical scavenging property.
Gupta
Y K
YK
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-11 0029, India. ykg@hotmail.com, ykg@aiims.aiims.ac.in
Sharma
Monisha
M
Chaudhary
Geeta
G
Katiyar
C K
CK
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011748:Pyrogallol; D051381:Rats; D017208:Rats, Wistar
D016166:Free Radical Scavengers; D010936:Plant Extracts; D020011:Protective Agents; D011748:Pyrogallol