Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia.
BACKGROUND
Several lines of evidence suggest that the pathophysiology of schizophrenia may be associated with altered noradrenergic and glucoregulatory function.


OBJECTIVE
The aim of this study was to investigate these alterations during a perturbed homeostatic state.


METHODS
Fifteen patients with schizophrenia and 13 healthy individuals were given a glucose deprivation challenge through administration of pharmacological doses of 2-deoxyglucose (2DG; 40 mg/kg), and their plasma was assayed over the next 60 min for concentrations of norepinephrine (NE), the intraneuronal NE metabolite dihydroxyphenylglycol (DHPG), epinephrine and glucose.


RESULTS
2DG induced significant increases in plasma NE, epinephrine and glucose levels in both groups with significantly greater NE and glucose increments in patients than in controls. For DHPG, 2DG produced increases in patients and decreases in the control subjects. NE responses correlated positively and significantly with the DHPG and glucose responses in schizophrenics, but not in controls.


CONCLUSIONS
These findings suggest that patients with schizophrenia have exaggerated NE and glucose responses to an acute metabolic perturbation.
Elman
Igor
I
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. ielman@partners.org
Rott
David
D
Green
Alan I
AI
Langleben
Daniel D
DD
Lukas
Scott E
SE
Goldstein
David S
DS
Breier
Alan
A
D000328:Adult; D000963:Antimetabolites / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D049268:Positron-Emission Tomography; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood*; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000378:metabolism
D000963:Antimetabolites; D001786:Blood Glucose; D002395:Catecholamines; D003847:Deoxyglucose; D009638:Norepinephrine; D004837:Epinephrine