title: [Perioperative heart rate control with landiolol for a patient with rapid atrial fibrillation complicated with low cardiac function].
abstract: A 62-year-old man complicated with old antero-septal wall myocardial infarction and atrial fibrillation suffered from lung and pancreas cancer. He underwent gastro-duodenum bypass surgery under epidural combined with general anesthesia. His ECG and echocardiogram revealed atrial fibrillation and his left ventricular ejection fraction was 35%. After the start of surgery under general anesthesia, EHR was stable between 80-100 beats x min(-1) but rapid atrial fibrillation developed with a rate of over 140 beats x min(-1) after epidural injection of 0.375% ropivacaine 3 ml. Treatment including continuous intravenous diltiazem and several bolus intravenous injections of verapamil failed to decrease the heart rate. Therefore we used landiolol, a short-acting beta blocker, to control heart rate. HR decreased without decreasing his blood pressure. Continuous landiolol infusion was maintained for 3 hours and 30 minutes in the ICU. After finishing infusion, his heart rhythm never became rapid atrial fibrillation. We conclude that landiolol is useful for heart rate control of rapid atrial fibrillation.
authors.affiliation: Department of Anesthesiology, Juntendo University Izunagaoka Hospital, Shizuoka 410-2295.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakai
authors.forename: Kaigen
authors.initials: K
authors.lastname: Igarashi
authors.forename: Mina
authors.initials: M
authors.lastname: Imai
authors.forename: Kunihisa
authors.initials: K
authors.lastname: Miura
authors.forename: Masanori
authors.initials: M
authors.lastname: Kanai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Okazaki
mesh_terms: D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008175:Lung Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000601:surgery; D014508:Urea / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000889:Anti-Arrhythmia Agents; D009025:Morpholines; C077049:landiolol; D014508:Urea