Development of guided bone regeneration membrane composed of beta-tricalcium phosphate and poly (L-lactide-co-glycolide-co-epsilon-caprolactone) composites.
To create biodegradable and thermoplastic materials for guided bone regeneration, GBR, and guided tissue regeneration, GTR, membranes, composites of beta-tricalcium phosphate, TCP, and biodegradable polyesters, poly (L-lactide-co-glycolide-co-epsilon-caprolactone), PLGC, and poly (L-lactide-co-epsilon-caprolactone), PLCL, were prepared by a heat-kneading method. The composites maintained thermoplasticity and mechanical strength by formation of a chemical interaction between Ca on TCP and C=O on the lactide segment of PLGC or PLCL. The composites also indicated composite effects in pH auto-regulation property and elongation of biodegradation period, e.g., the composites maintained their mechanical strength up to 12 weeks after soaking in both physiological and phosphate-buffered saline, and the period was sufficient time to use for GBR and GTR membranes. Animal tests for GBR indicated that the present composite membrane successfully regenerated beagles' mandible defects 10 x 10 x 10 mm3 in size. These results suggested that the TCP/PLGC bioresorbable composites could be utilized for GBR and GTR therapy.
Kikuchi
Masanori
M
Biomaterials Center, National Institute for Materials Science, Regeneration Materials Group, 1-1, Namiki, Tsukuba, Ibaraki 305-0044, Japan. kikuchi.masanori@nims.go.jp
Koyama
Yoshihisa
Y
Yamada
Takeki
T
Imamura
Yukari
Y
Okada
Takao
T
Shirahama
Noriaki
N
Akita
Kazumi
K
Takakuda
Kazuo
K
Tanaka
Junzo
J
D000818:Animals; D001673:Biodegradation, Environmental; D001861:Bone Regeneration; D002130:Calcium Phosphates / Q000737:chemistry*; D004285:Dogs; D008297:Male; D008567:Membranes, Artificial; D011091:Polyesters / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D002130:Calcium Phosphates; D008567:Membranes, Artificial; D011091:Polyesters; C485817:beta-tricalcium phosphate; C062968:lactide-caprolactone copolymer