title: 5-Arylidene-2(5H)-furanone derivatives: synthesis and structure-activity relationship for cytotoxicity.
abstract: Thirty-eight 5-arylidene-2(5H)-furanone derivatives possessing halo-, methoxy-, oxo-, dioxo-, and thiophenyl groups as well as anthraquinone and naphthquinone moieties were synthesized, and their cytotoxicity was evaluated against various cancer cell lines. The introduction of halogen atoms or nitro group at aromatic ring of 5-arylidene-2(5H)-furanone was shown to increase the cytotoxicity with 5-(3-nitrobenzylidene)-2(5H)-furanone (21) being the most potent. Among anthracenyl or naphthalenyl derivatives, (E)-5-[2-(1,4-dimethoxy-9,10-dioxo) anthracenyl]-2(5H)-furanone (34) showed the most potent cytotoxic activity.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Seong-Cheol
authors.initials: SC
authors.lastname: Bang
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Yun
authors.forename: Byung-Zun
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D045744:Cell Line, Tumor; D005663:Furans / Q000737:chemistry* / Q000633:toxicity*; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans