title: Impact of erythropoietic activity on red cell parameters in chronic renal failure patients.
abstract: We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic activity led to a bias in red cell parameter determination. The percentage of hypochromic red blood cells, usually used as the most effective predictor of response to iron supplementation, increased following the appearance of a younger red cell population since the same Hb content in these younger, larger cells gives a lower Hb concentration.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bovy
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Krzesinski
authors.forename: André
authors.initials: A
authors.lastname: Gothot
authors.forename: Yves
authors.initials: Y
authors.lastname: Beguin
mesh_terms: D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000473:pathology*; D004920:Erythropoiesis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*