title: Pulsatile luteinizing hormone disruption in depression.
abstract: Two independent groups recently published data comparing pulsatile luteinizing hormone (LH) release between depressed and control women. Despite similar populations and LH sampling frequency, they reached different conclusions: Meller et al. [Am. J. Psych. 154 (1997) 1454] found disruption of normal LH pulsatility in depressed women, whereas Young et al. [Arch. Gen. Psych. 57 (2000) 1157] did not. To resolve this discrepancy, the current study applies a single, well-established statistical method, spectral analysis, to the two data sets and concludes that both depressed populations display significantly altered LH pulsatile release.
authors.affiliation: Division of Biostatistics, School of Public Health MMC303, University of Minnesota, 412 Delaware Street SE, Mayo A-460, Minneapolis, MN 55455, USA. pat@biostat.umn.edu
authors.forename: Patricia
authors.initials: P
authors.lastname: Grambsch
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Young
authors.forename: William H
authors.initials: WH
authors.lastname: Meller
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D005498:Follicular Phase / Q000097:blood*; D005583:Fourier Analysis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008183:Luteal Phase / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008875:Middle Aged; D008954:Models, Biological; D010507:Periodicity
chemical_list: D007986:Luteinizing Hormone