title: Evaluation of muscle metabolic activity in the lower limb of a transfemoral amputee using a prosthesis by using (18)F-FDG PET imaging--an application of PET imaging to rehabilitation.
abstract: This study used FDG PET to evaluate the lower limb muscles metabolic activities of transfemoral amputees during walking with prostheses. As a preliminary study, FDG PET was applied for two normal adult volunteers to evaluate muscle activity in the lower extremities after gait exercise. This same method was applied for two amputee volunteers with prostheses. We found that FDG accumulated more in both gluteus medius muscles after gait exercise compared to other muscles in normal adult volunteers. In the skilled amputee volunteer, FDG uptake increased in the adductor and gluteus medius in the amputated side, while in the unskilled the adductor, gluteus maximus, and gluteus medius showed increased FDG uptake only in the normal side. This result suggests that basic metabolic changes such as an increase in oxidative metabolism and less reliance on glycolytic activity would occur as a result of skeletal muscle training in amputees.
authors.affiliation: Faculty of Medicine, Department of Orthopaedic Surgery, Gunma University, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan. tshinoza@showa.gunma-u.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Shinozaki
authors.forename: Keiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yamaji
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ichikawa
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
authors.forename: Kenji
authors.initials: K
authors.lastname: Takagishi
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
mesh_terms: D000328:Adult; D000674:Amputees / Q000534:rehabilitation*; D005081:Exercise Therapy; D019788:Fluorodeoxyglucose F18; D005684:Gait; D006801:Humans; D007866:Leg; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000378:metabolism; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18