title: Assessment of the efficacy of joint lavage versus joint lavage plus corticoids in patients with osteoarthritis of the knee.
abstract: OBJECTIVE
  Joint lavage (JL), involves the passage of cold sterile 0.9% saline through the knee joint in order to have the fluid reach the inside of the joint capsule. This technique was evaluated as a local treatment for osteoarthritis (OA) of the knee alone (JL) and in combination with intra-articular infiltration with glucocorticoids (JLC).
  
  
  METHODS
  An overall 299 knees belonging to 205 patients (22% males, 78% females) with a mean age of 67 +/- 8 years and osteoarthritis of the knee of radiological grade II or III on the Kellgren scale were randomised in the ratio of 1:4 into two therapeutic groups, namely: JL (n = 62) and JLC (n = 237). All patients received joint lavage on day 0; in those of the JLC group, joint lavage was followed by infiltration of 40 mg of triamcinolone acetonide. The efficacy of both treatments was assessed by recording the corresponding values for the following variables: pain strength as measured by a visual analogy scale (VAS), effusion, crepitation, restricted motion, of osteoarthritis of the knee. spontaneous pain, pain on pressure, pain on passive motion and pain on active motion; all of these were recorded at the onset of the study, and after 1 and 3 months.
  
  
  RESULTS
  There were no significant differences in the values of the variables at the different followup times. Also, pain severity was similar in both treatment groups. Thus, VAS for pain was 7.3 +/- 0.3 for the JL group and 7.1 +/- 0.2 for the JLC group at the onset, and decreased to 3.0 +/- 0.3 in the former and 2.8 +/- 0.2 in the latter after 1 month; the decrease was statistically significant in both cases. After 3 months, the JL and JLC groups had a VAS of 3.5 +/- 0.3 and 3.8 +/- 0.2, respectively.
  
  
  CONCLUSIONS
  The results of this work suggest the absence of significant differences between the two treatments, such that both joint lavage alone and with infiltration with corticoids can be concluded as similarly effective for the symptomatic management
authors.affiliation: Rheumatology Service, 'Reina Sofía' University Hospital, Córdoba, Spain.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Frías
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Caracuel
authors.forename: Alejandro
authors.initials: A
authors.lastname: Escudero
authors.forename: Jose
authors.initials: J
authors.lastname: Rumbao
authors.forename: Veronica
authors.initials: V
authors.lastname: Pérez-Gujo
authors.forename: Maria
authors.initials: M
authors.lastname: del Carmen Castro
authors.forename: Pilar
authors.initials: P
authors.lastname: Font
authors.forename: José
authors.initials: J
authors.lastname: González
authors.forename: Eduardo
authors.initials: E
authors.lastname: Collantes
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D013030:Spain; D007507:Therapeutic Irrigation; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones