title: Myanmar dengue outbreak associated with displacement of serotypes 2, 3, and 4 by dengue 1.
abstract: In 2001, Myanmar (Burma) had its largest outbreak of dengue-15,361 reported cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), including 192 deaths. That year, 95% of dengue viruses isolated from patients were serotype 1 viruses belonging to two lineages that had diverged from an earlier, now extinct, lineage sometime before 1998. The ratio of DHF to DSS cases in 2001 was not significantly different from that in 2000, when 1,816 cases of DHF/DSS were reported and dengue 1 also was the most frequently isolated serotype. However, the 2001 ratio was significantly higher than that in 1998 (also an outbreak year) and in 1999, when all four serotypes were detected and serotypes 1, 2, and 3 were recovered in similar numbers. The large number of clinical cases in 2001 may have been due, in part, to a preponderance of infections with dengue 1 viruses.
authors.affiliation: Queensland University of Technology, Brisbane, Australia.
authors.forename: Hlaing Myat
authors.initials: HM
authors.lastname: Thu
authors.forename: Kym
authors.initials: K
authors.lastname: Lowry
authors.forename: Thein Thein
authors.initials: TT
authors.lastname: Myint
authors.forename: Than Nu
authors.initials: TN
authors.lastname: Shwe
authors.forename: Aye Maung
authors.initials: AM
authors.lastname: Han
authors.forename: Kyu Kyu
authors.initials: KK
authors.lastname: Khin
authors.forename: Kyaw Zin
authors.initials: KZ
authors.lastname: Thant
authors.forename: Soe
authors.initials: S
authors.lastname: Thein
authors.forename: John
authors.initials: J
authors.lastname: Aaskov
mesh_terms: D001315:Australia / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000145:classification*; D004196:Disease Outbreaks; D006801:Humans; D010802:Phylogeny; D012703:Serotyping