title: Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones.
abstract: The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
authors.affiliation: College of Pharmacy, Chungnam National University, Taejon 305-764, Korea. jungshh@cnu.ac.kr
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Jung
authors.forename: Hui-Soon
authors.initials: HS
authors.lastname: Lee
authors.forename: Nam-Soo
authors.initials: NS
authors.lastname: Kim
authors.forename: Hwan-Mook
authors.initials: HM
authors.lastname: Kim
authors.forename: Moonsun
authors.initials: M
authors.lastname: Lee
authors.forename: Dong-Rack
authors.initials: DR
authors.lastname: Choi
authors.forename: Jung-Ah
authors.initials: JA
authors.lastname: Lee
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Chung
authors.forename: Eun-Yi
authors.initials: EY
authors.lastname: Moon
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Hwang
authors.forename: Seung-Kyoo
authors.initials: SK
authors.lastname: Seong
authors.forename: Dug-Keun
authors.initials: DK
authors.lastname: Lee
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000633:toxicity*; D051379:Mice
chemical_list: D048289:Imidazolidines