title: Atypical lipomatous tumor: molecular characterization.
abstract: OBJECTIVE
  Atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs) are one of the more frequent mesenchymal neoplasms and are characterized by specific chromosome aberrations: supernumerary chromosome or giant marker chromosome or both. Extra copies of known oncogenes such as MDM2, CDK4, SAS, HMGA2 and others are present in this abnormal genetic material.
  
  
  RESULTS
  In the past few years, several papers have further dissected the genetic alterations present in these tumors, allowing the identification of new potential oncogenes.
  
  
  CONCLUSIONS
  ALT/WDLs represent therefore an interesting model for assessing the potential role of these oncogenes, not only in the pathogenesis, but also as a therapeutic target.
authors.affiliation: Department of Pathology, San Raffaele Hospital, Via Olgettina 60, Milan, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Arrigoni
authors.forename: Claudio
authors.initials: C
authors.lastname: Doglioni
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002869:Chromosome Aberrations; D018450:Disease Progression; D006801:Humans; D008067:Lipoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008080:Liposarcoma / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008967:Molecular Biology; D012303:Ring Chromosomes
chemical_list: D014408:Biomarkers, Tumor