Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats.
The lipid-lowering efficacy of hesperetin was revealed in preliminary studies on experimental animals. As such, the current study compared the effect of hesperetin 7-O-lauryl ether, with that of hesperetin and lovastatin on the lipid profile and cholesterol-regulating mechanism in high-cholesterol-fed rats. Male rats were fed a high-cholesterol diet (1%, wt/wt) or high-cholesterol diet supplemented with lovastatin (1, 0.02%, wt/wt), hesperetin (2, 0.02%, wt/wt), or hesperetin 7-O-lauryl ether (3, 0.031%, wt/wt) for six weeks. The supplemental amount of 3 was 0.066mmol/100g diet as an equivalent to the supplemental amount of 2. The plasma total cholesterol and triglyceride levels were significantly lowered by the 2 and 3 supplements compared with the control or 1-supplemented group. The hepatic HMG-CoA reductase activities were also significantly lower in all the supplemented groups compared with the control group, and the hepatic ACAT activity was significantly lower in the 2- and 3-supplemented groups. The supplementation of 3 resulted in a higher excretion of total neutral sterol and total fecal sterol compared with the control or 1-supplemented group. Accordingly, overall, compound 3, exhibited a more potent plasma lipid-lowering effect than compound 1 based on inhibiting cholesterol biosynthesis and esterification, while also increasing the fecal sterol excretion.
Choi
Gab-Sun
GS
Department of Food Science and Nutrition, Kyungpook National University, 1370 Sankyuk Dong Puk-Ku, 702-701 Daegu, South Korea.
Lee
Sangku
S
Jeong
Tae-Sook
TS
Lee
Mi-Kyung
MK
Lee
Jeong-Sun
JS
Jung
Un Ju
UJ
Kim
Hye-Jin
HJ
Park
Yong Bok
YB
Bok
Song-Hae
SH
Choi
Myung-Sook
MS
D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D004987:Ethers / Q000737:chemistry / Q000494:pharmacology*; D005243:Feces / Q000737:chemistry; D006569:Hesperidin / Q000737:chemistry / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000032:analysis / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D015394:Molecular Structure; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013261:Sterols / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
D002791:Cholesterol, Dietary; D004987:Ethers; D000960:Hypolipidemic Agents; D008055:Lipids; D013261:Sterols; C484475:hesperetin 7-O-lauryl ether; D006569:Hesperidin