Diastereoselective zinc-catalyzed conjugate addition of alkynes.
[reaction: see text] The conjugate addition of in situ generated zinc alkynylides is reported. The use of chiral, ephedrine derived acceptors provides access to enantiomerically enriched beta-alkynyl acids in good yields.
Knöpfel
Thomas F
TF
Laboratorium für Organische Chemie, ETH-Hönggerberg, CH-8093 Zurich, Switzerland.
Boyall
Dean
D
Carreira
Erick M
EM