[Auricular chondritis. Experimental model in rats].
The general pattern of local inflammation in the rat is developed in the pad of the paw. In otorhinolaryngology a model of local inflammation can be reached in the rat ear by means of the production of an auricular chondritis. For that, we have protocolized the methodology. The induction of inflammation is carried out by the substance vegetable carrageenan. It has been verified by histological studies the inflammation generated, as well as studying the action of antiinflammatory, proinflammatory and inflammatory compounds. The inflammation has been measured by nonius and by determination of the activity of the myeloperoxidase enzyme. After these studies we can validate the auricular chondritis in rat as an experimental model of local inflammation in otorhinolaryngology.
López González
M A
MA
Servicio de Otorrinolaringología, Hospitales Universitarios Virgen del Rocio, Servicio Andaluz de Salud, Sevilla. malopez@cica.es
Loizaga Iriondo
J M
JM
Delgado Moreno
F
F
D000818:Animals; D002356:Cartilage / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000378:metabolism / Q000473:pathology; D004431:Ear, External / Q000378:metabolism / Q000473:pathology*; D005260:Female; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D014660:Vasoactive Intestinal Peptide