title: [Diagnosis and treatment of vasoactive intestinal peptide-secreting-tumors: one case report and 15 years review in China].
abstract: OBJECTIVE
  To discuss the experiences of diagnosis and treatment for vasoactive intestinal peptide-secreting-tumors (VIPoma) by summarizing clinical informations of 15 patients with VIPoma.
  
  
  METHODS
  To analyze Clinical manifestations, laboratory examinations, imaging features, operation, pathological findings and follow up survey of 15 patients, among them 1 case from our hospital and the other 14 cases were searched in chinese biological and medical literature database from Jan 1987 to Dec 2002.
  
  
  RESULTS
  The main clinical manifestation include periodical secretory watery diarrhea, hypokalemia, achlorhydria, in addition, periodical backache, skin rash, and polyps of colon were presented in the case in our hospital. The immunohistochemical expression of many kinds of digestive hormone including VIP presented positive; All clinical symptoms of which except polyps disappeared after operation, elevated VIP data in serum also markedly decreased. Part resection of superior mesenteric vein was performed in the same patient.
  
  
  CONCLUSIONS
  VIPoma is rare. Typical symptoms and the serum value of VIP were keys to diagnosis, the operation is the most effective means for treatment. Resection of tumor, Radiofrequency tissue ablation, liver transplantation can be selected for metastatic VIPoma in the liver.
authors.affiliation: Department of Surgery, Second Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310009, China.
authors.forename: Jiang-tao
authors.initials: JT
authors.lastname: Li
authors.forename: Shu-you
authors.initials: SY
authors.lastname: Peng
authors.forename: Ying-bin
authors.initials: YB
authors.lastname: Liu
authors.forename: He-qing
authors.initials: HQ
authors.lastname: Fang
authors.forename: Yu-lian
authors.initials: YL
authors.lastname: Wu
authors.forename: Xin-bao
authors.initials: XB
authors.lastname: Wang
authors.forename: Zhe
authors.initials: Z
authors.lastname: Tang
authors.forename: Hao-ran
authors.initials: HR
authors.lastname: Qian
authors.forename: Cheng
authors.initials: C
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D003969:Vipoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*
chemical_list: D014660:Vasoactive Intestinal Peptide