[Study on T cell subsets and their activated molecules from the convalescent SARS patients during two follow-up surveys].
OBJECTIVE
To explore the changes of peripheral blood T cell subsets and their activated molecules in convalescent SARS patients.


METHODS
In two follow-up surveys of the SARS patients discharged from our hospital, the changes of CD3(+), CD4(+), CD8(+), CD8(+) CD28(+), CD8(+) CD28(-), CD3(+) CD25(+), CD3(+) CD69(+), CD3(+) HLA-DR(+)T cells and the ratio of CD4(+)/CD8(+) T cells in peripheral blood of SARS patients treated unitedly with Chinese and Western medicines were detected by flow cytometry.


RESULTS
In two follow-up surveys, the percentages of CD3(+), CD4(+), CD8(+) CD28(+) T cells and the ratio of CD4(+)/CD8(+) T cells were remarkably lower than those of normal values(P<0.05), while the percentage of CD8(+) CD28 (-) T cells was higher(P<0.01). As for the percentages of CD3(+), CD8(+), CD4(+)/CD8(+), CD3(+) CD25(+), CD3(+) CD69(+) and CD3(+) HLA-DR(+) T cells, there was marked difference between 1st and 2nd follow-up results, but for other molecules there was no notable difference.


CONCLUSIONS
The convalescent SARS patients' immune function gradually recovers, and the effect of SARS virus on activation of T cells gradually disappears.
Cai
Cui
C
The Central Laboratory, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China. X-Zeng@21cn.com
Zeng
Xing
X
Ou
Ai-hua
AH
Huang
Yu
Y
Zhang
Xian
X
D017252:CD3 Complex / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000378:metabolism; D003289:Convalescence; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D018655:Lymphocyte Count; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens