title: Growth hormone deficiency and related disorders: insights into causation, diagnosis, and treatment.
abstract: Advances in molecular biology have led to the identification of mutations within several novel genes associated with the phenotype of isolated growth hormone deficiency, combined pituitary hormone deficiency, and syndromes such as septo-optic dysplasia. Progress has also been made in terms of the optimum diagnosis of disorders of stature and their treatment. The use of growth hormone for the treatment of adults with growth hormone deficiency and conditions such as Turner's syndrome, Prader-Willi syndrome, intrauterine growth restriction, and chronic renal failure has changed the practice of endocrinology, although cost-benefit implications remain to be established.
authors.affiliation: Institute of Child Health, University College London, London WC1N 1EH, UK.
authors.forename: Mehul
authors.initials: M
authors.lastname: Dattani
authors.forename: Michael
authors.initials: M
authors.lastname: Preece
mesh_terms: D000818:Animals; D001827:Body Height; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006128:Growth / Q000235:genetics / Q000502:physiology; D006130:Growth Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency* / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D009154:Mutation; D010903:Pituitary Gland, Anterior / Q000196:embryology / Q000502:physiology; D010907:Pituitary Hormones / Q000172:deficiency
chemical_list: D010907:Pituitary Hormones; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone