Basic science and pathophysiology of ocular allergy.
Ocular allergy includes several clinical subtypes ranging from the mild seasonal allergic conjunctivitis to the potentially sight-threatening atopic keratoconjunctivitis. Current therapies, particularly for the severe forms of disease, need to be more localized and with fewer side effects. For this to be achieved, it requires a better understanding of the basic mechanisms involved. In this chapter, recent findings are discussed that suggest that it is important to take an integrated approach, including both immune and structural elements of the eye. This provides potential new strategies for therapy, addressing the influence of structural cells in disease. These might influence the immune processes that take place and, as the structural cells are precisely localized, topical application is likely to be effective.
Calder
Virginia L
VL
Division of Clinical Ophthalmology, Institute of Ophthalmology, UCL, 11/43 Bath Street, London EC1V 9EL, UK. v.calder@ucl.ac.uk
Lackie
Peter M
PM
D003228:Conjunctiva / Q000033:anatomy & histology / Q000166:cytology / Q000503:physiopathology*; D003233:Conjunctivitis, Allergic / Q000276:immunology / Q000503:physiopathology*; D016207:Cytokines / Q000096:biosynthesis; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D004848:Epithelium / Q000276:immunology; D006801:Humans; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D009092:Mucous Membrane / Q000033:anatomy & histology / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines