Prediction of protein folding rates from the amino acid sequence-predicted secondary structure.
We present a method for predicting folding rates of proteins from their amino acid sequences only, or rather, from their chain lengths and their helicity predicted from their sequences. The method achieves 82% correlation with experiment over all 64 "two-state" and "multistate" proteins (including two artificial peptides) studied up to now.
Ivankov
Dmitry N
DN
Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, Moscow Region, Russia.
Finkelstein
Alexei V
AV
D000595:Amino Acid Sequence; D030562:Databases, Protein; D007700:Kinetics; D008958:Models, Molecular; D017510:Protein Folding; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
D011506:Proteins; D014867:Water