title: Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation.
abstract: A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole-4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea.
authors.forename: Sung-Yu
authors.initials: SY
authors.lastname: Hong
authors.forename: Kwang-Hoe
authors.initials: KH
authors.lastname: Chung
authors.forename: Hea-Jung
authors.initials: HJ
authors.lastname: You
authors.forename: Ik Hwa
authors.initials: IH
authors.lastname: Choi
authors.forename: Mi Jin
authors.initials: MJ
authors.lastname: Chae
authors.forename: Ja-Young
authors.initials: JY
authors.lastname: Han
authors.forename: Ok-Jai
authors.initials: OJ
authors.lastname: Jung
authors.forename: Soo-Jung
authors.initials: SJ
authors.lastname: Kang
authors.forename: Chung-Kyu
authors.initials: CK
authors.lastname: Ryu
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D001562:Benzimidazoles; D006131:Growth Inhibitors; D010982:Platelet-Derived Growth Factor; D048031:JNK Mitogen-Activated Protein Kinases