[Effect of perfluoroorganic compounds on growth of streptomycetes and biosynthesis of antibiotic daunorubicin].
The use of perfluoroorganic compounds, i.e. perfluorodecalin and "Perftoran", a blood substitute with the gas transfer function, known as "blue blood" (containing 3 vol. % of perfluoromethylcyclohexylpiperidin and 7 vol. % of perfluorodecalin as emulsion with the average particle size of 0.07 microns) in biotechnology for intensification of the Streptomyces purpurogeniscleroticus growth under submerged conditions was shown promising for the first time. An increase of the biomass output and higher yields of daunorubicin were also demonstrated.
Bakulin
M K
MK
Kucherenko
A S
AS
Bakulina
L V
LV
Shvedov
V V
VV
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D003470:Culture Media / Q000737:chemistry; D003630:Daunorubicin / Q000096:biosynthesis*; D005466:Fluorocarbons / Q000737:chemistry / Q000494:pharmacology*; D010316:Particle Size; D013302:Streptomyces / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D005466:Fluorocarbons; C008805:perfluorodecalin; C063334:perftoran; D003630:Daunorubicin