title: Disinhibition of the somatosensory cortex in cervical dystonia-decreased amplitudes of high-frequency oscillations.
abstract: OBJECTIVE
  To determine whether patients with cervical dystonia have electrophysiological signs of disinhibition in the somatosensory cortex by recording high-frequency oscillations (HFOs) in somatosensory evoked potentials (SEPs).
  
  
  METHODS
  HFOs were recorded in 13 patients and 10 age-matched control subjects, and the data were analyzed statistically by paired comparison and by Pearson's correlation.
  
  
  RESULTS
  In patients with cervical dystonia, the early part of HFOs showed a significant decrease in amplitude, and the amplitude ratios of both early and late parts of HFOs/N20 potential were also significantly decreased. The amplitudes of HFOs and N20 potential were linearly correlated in the control subjects but not in dystonia patients.
  
  
  CONCLUSIONS
  Patients with cervical dystonia may suffer from a disturbance of inhibition in the sensory cortex. This disturbance is reflected by decreased HFO amplitude, representing decreased activities of inhibitory interneurons in area 3b.
authors.affiliation: Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. keninoue@hiroshima-u.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Inoue
authors.forename: Isao
authors.initials: I
authors.lastname: Hashimoto
authors.forename: Takushi
authors.initials: T
authors.lastname: Shirai
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
authors.forename: Takafumi
authors.initials: T
authors.lastname: Miyachi
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Mimori
authors.forename: Masayasu
authors.initials: M
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004292:Dominance, Cerebral; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000627:therapeutic use; D009433:Neural Inhibition; D009991:Oscillometry; D011930:Reaction Time; D013003:Somatosensory Cortex / Q000503:physiopathology*; D014103:Torticollis / Q000188:drug therapy / Q000503:physiopathology*; D014282:Trihexyphenidyl / Q000627:therapeutic use
chemical_list: D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl