[Expression of pepsinogen C in gastric cancer and its precursor].
OBJECTIVE
To investigate the dynamic expression of pepsinogen C (PGC) and its value in detection of precursor and gastric cancer.


METHODS
Immunohistochemistry was used to examine the expression of PGC in 424 biopsy specimens of stomach mucosa collected by gastroscopy.


RESULTS
The positive rate of PGC expression in 54 cases of normal gastric mucosa was 100% and 2.4% in 124 cases of gastric cancer. The positive rate of PGC expression decreased in the order of superficial gastritis/gastric ulcer or erosion-->atrophic gastritis or gastric dysplasia-->gastric cancer (P < 0.01).


CONCLUSIONS
The expression of PGC is negatively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. PGC has high sensitivity and specificity in diagnosis of precursor of gastric cancer and can be a good indicator in the screening and diagnosis of precursor of gastric cancer and gastric cancer.
Ning
Pei-fang
PF
Cancer Institute of the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
Sun
Li-ping
LP
Liu
Hui-jie
HJ
Yuan
Yuan
Y
D000328:Adult; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000473:pathology*; D005756:Gastritis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D020115:Pepsinogen C / Q000032:analysis*; D010437:Peptic Ulcer / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
D020115:Pepsinogen C