[Spectrum of ST-T-wave changes in hereditary long-QT syndrome in Chinese].
OBJECTIVE
To evaluate the spectrum of ST-T-wave patterns in Chinese patients with hereditary long-QT syndrome.


METHODS
ECGs of 61 families were studied to determine ST-T-wave patterns. Genotypes were identified by sequencing.


RESULTS
32 cases showed similarity to LQT1, 41 to LQT2 and 2 to LQT3 in ECG, and 3 cases could not be classified. QTc of the patients with symptom was (0.547 +/- 0.08) sec and that of the patients without symptoms was (0.526 +/- 0.06) sec, both were much longer than that of normal members of the families. T wave patterns were different in 48 cases at different time. QTc difference in a same person between two times or DeltaQTc were as follows: (0.048 +/- 0.057) sec in patients and (0.023 +/- 0.017) sec in normal members (P < 0.001). 12 cases of LQT1 and 11 cases of LQT2 were identified by genotype sequencing.


CONCLUSIONS
There are some differences in ST-T waves between these Chinese hereditary long-QT syndrome patients and European and American patterns. These patients showed greater variability in ST-T wave pattern including the changes in the same type, in the same pedigree and in the same patients at different time.
Liu
Wen-ling
WL
Department of Cardiology, People's Hospital, Peking University, Beijing 100044, China. wlliu@21cn.com
Hu
Da-yi
DY
Li
Zhi-ming
ZM
Li
Cui-lan
CL
Li
Yun-tian
YT
Qin
Xu-guang
XG
Li
Lei
L
D000293:Adolescent; D000328:Adult; D015716:Electrocardiography, Ambulatory; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged