title: Oncological diagnosis using (11)C-choline-positron emission tomography in comparison with 2-deoxy-2-[(18)F] fluoro-D-glucose-positron emission tomography.
abstract: OBJECTIVE
  To assess and compare the usefulness of (11)C-Choline-positron emission tomography (PET) with that of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG)-PET for the differentiation between benign and malignant in various tumors.
  
  
  METHODS
  We examined 38 consecutive patients with various tumors, including seven patients with brain tumors, two with oral cavity tumor, two with esophageal cancer, six with lung cancer, 11 with bone tumor, nine with soft tissue tumors, and one with myeloma. (11)C-Choline-PET and FDG-PET were performed from five minutes and 40 minutes, respectively, after injection of 275-455 MBq tracer. Tracer uptakes were evaluated by the standardized uptake value (SUV) and were analyzed in according to the pathologic data.
  
  
  RESULTS
  (11)C-Choline uptake in malignancies (3.9 +/- 1.7, n=24) was significantly higher than that in benign lesions (1.7 +/- 1.2, n=14) (P < 0.0001). On the other hand, the FDG uptake in malignancies was 4.9 +/- 2.0 (n=24) and was also significantly larger than that in benign lesions 1.6 +/- 1.3 (n=14) (P < 0.0001). The (11)C-Choline uptake in all the lesions correlated with FDG uptake (r=0.658, P < 0.02, n=38). According to the receiver operating characteristic (ROC) analysis, the area under the ROC curve for (11)C-Choline-PET was 0.871, and with no significant difference compared to FDG-PET with the area of 0.929.
  
  
  CONCLUSIONS
  This study demonstrated that (11)C-Choline-PET is similar to FDG-PET in differentiation between malignant and benign lesion in various tumors.
authors.affiliation: Department of Nuclear Medicine and Diagnostic Radiology, Gunma University School of Medicine, Gunma, Japan. tian@med.gunma-u.ac.jp
authors.forename: Mei
authors.initials: M
authors.lastname: Tian
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Higuchi
authors.forename: Noboru
authors.initials: N
authors.lastname: Oriuchi
authors.forename: Keigo
authors.initials: K
authors.lastname: Endo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002794:Choline / Q000031:analogs & derivatives*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography
chemical_list: C447081:methyl carbon-11 choline; D019788:Fluorodeoxyglucose F18; D002794:Choline