title: Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
abstract: Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
authors.affiliation: Faculty of Sciences and Techniques Gueliz, Marrakesh, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Taourirte
authors.forename: L Ait
authors.initials: LA
authors.lastname: Mohamed
authors.forename: A
authors.initials: A
authors.lastname: Rochdi
authors.forename: J J
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: S
authors.initials: S
authors.lastname: Fernández
authors.forename: M
authors.initials: M
authors.lastname: Ferrero
authors.forename: V
authors.initials: V
authors.lastname: Gotor
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: H B
authors.initials: HB
authors.lastname: Lazrek
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D019281:Dimerization; D005656:Fungal Proteins / Q000737:chemistry*; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000187:drug effects; D015498:HIV-2 / Q000187:drug effects; D006801:Humans; D008049:Lipase / Q000737:chemistry*; D018119:Stavudine / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D005656:Fungal Proteins; D015215:Zidovudine; D018119:Stavudine; D008049:Lipase; C431349:lipase B, Candida antarctica