Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp-based and laser-induced fluorescence detection.
Commercial capillary electrophoresis instrumentation with XeHg lamp-based and laser induced fluorescence (LIF) detection is employed for analysis of urinary 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) and its major metabolites, urinary metabolites of acetylsalicylic acid, urinary benzoylecgonine in an immunoassay format, and albendazole sulfoxide and albendazole sulfone in plasma. For the examples studied, the data suggest that the lamp-based detector can be employed for the monitoring of pharmacological and toxicological relevant solute concentrations, and thus represents an attractive alternative to LIF detection.
Caslavska
Jitka
J
Department of Clinical Pharmacology, University of Bern, Murtenstrasse 35, CH-3010 Bern, Switzerland.
Thormann
Wolfgang
W
D015766:Albendazole / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood; D001241:Aspirin / Q000032:analysis* / Q000652:urine; D001826:Body Fluids / Q000737:chemistry*; D003042:Cocaine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000652:urine; D019075:Electrophoresis, Capillary / Q000295:instrumentation*; D007834:Lasers; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000032:analysis* / Q000652:urine; D013050:Spectrometry, Fluorescence / Q000295:instrumentation
C027187:albendazole sulfone; C005618:benzoylecgonine; D015766:Albendazole; D003042:Cocaine; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D001241:Aspirin