Diagnosis and management of pergolide-induced fibrosis.
We report on 2 patients treated with pergolide, 1 of whom developed pleural fibrosis and the other retroperitoneal fibrosis. In both cases, an extensive diagnostic evaluation and surgical intervention were required to reach a diagnosis. Based on our experience with these patients and a review of cases of pergolide-induced fibrosis in the English-language literature, we propose guidelines for the diagnosis and management of this rare complication.
Agarwal
Pinky
P
Department of Neurology, Columbia-Presbyterian Medical Center, Division of Movement Disorders, New York, New York, USA.
Fahn
Stanley
S
Frucht
Steven J
SJ
D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001707:Biopsy, Needle; D001980:Bronchi / Q000473:pathology; D005260:Female; D005355:Fibrosis / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy*; D010479:Pergolide / Q000009:adverse effects* / Q000627:therapeutic use; D010995:Pleural Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D012185:Retroperitoneal Fibrosis / Q000139:chemically induced* / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
D000978:Antiparkinson Agents; D010479:Pergolide