Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh.
The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence of Vibrio cholerae O139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic setting. Although a higher baseline vibriocidal titer correlated with protection from V. cholerae O1, infection still developed in some contacts with very high titers. No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection.
Saha
Debasish
D
International Centre for Diarrheal Disease Research, Bangladesh.
LaRocque
Regina C
RC
Khan
Ashraful I
AI
Harris
Jason B
JB
Begum
Yasmin Ara
YA
Akramuzzaman
Syed M
SM
Faruque
Abu S G
AS
Ryan
Edward T
ET
Qadri
Firdausi
F
Calderwood
Stephen B
SB
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001459:Bangladesh / Q000453:epidemiology; D002771:Cholera / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D014505:Urban Population; D041241:Vibrio cholerae O1 / Q000276:immunology*; D041242:Vibrio cholerae O139 / Q000276:immunology*
D000907:Antibodies, Bacterial