Tau phosphorylation and assembly.
Neurofibrillary tangles, one of the aberrant structures found in the brain of Alzheimer's disease patients are mainly composed of tau in hyperphosphorylated form. Thus, a possible relation between phosphorylation and assembly of tau proteins has been analysed. By doing in vitro studies we have observed that in certain conditions, where compounds from oxidative stress are present, the capacity of tau for self assembly increases upon phosphorylation.
Gómez-Ramos
Alberto
A
Centro de Biología Molecular, (CSIC/UAM), Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
Smith
Mark A
MA
Perry
George
G
Avila
Jesús
J
D000544:Alzheimer Disease / Q000378:metabolism*; D006801:Humans; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism*
D016875:tau Proteins