Acute stress impairs trace eye blink conditioning in females without altering the unconditioned response.
Exposure to an acute stressor of inescapable swimming or intermittent tail shocks impairs classical eye blink conditioning 24h later in female rats. This effect is often attributed to a deficit in "learning," but since stress has been shown to induce analgesia, an alternative explanation is that stressor exposure reduces conditioning by lessening the perceived intensity of the unconditioned stimulus (US). To address this possibility we examined the amplitude of the unconditioned response (UR) during training and found that although exposure to the stressor impaired trace conditioning, there was no difference in the UR amplitude. We also found that eye blink responses to different US intensities (4-12 V) in the absence of training were unaffected by stressor exposure. Taken together, these experiments indicate that the stress-induced impairment of conditioning in females is not due to a decreased perception of US strength.
Bangasser
Debra A
DA
Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, NJ, USA. dbangasser@yahoo.com
Shors
Tracey J
TJ
D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D003215:Conditioning, Eyelid / Q000502:physiology*; D003463:Cues; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D007266:Inhibition, Psychological; D010146:Pain / Q000503:physiopathology / Q000523:psychology; D010470:Perceptual Masking / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012677:Sensation / Q000502:physiology*; D012737:Sex Factors; D013312:Stress, Physiological / Q000503:physiopathology* / Q000523:psychology