title: [Expression and its significance of b-FGF in human benign prostatic hyperplasia and prostatic carcinoma tissues].
abstract: OBJECTIVE
  To investigate the clinical significance of basic fibroblast growth factor (b-FGF) in human benign prostatic hyperplasia (BPH) and prostatic carcinoma (Pca).
  
  
  METHODS
  b-FGF expressions were examined by RNA dot blot hybridization and immunohistochemical staining in prostate tissues from 40 normal cases (NP), 38 BPH and 36 Pca.
  
  
  RESULTS
  The expressions of b-FGF in BPH and Pca tissues were significantly higher than those in normal prostate tissues (P < 0.01). There was no significant correlation between the increased expression of b-FGF and the graduation of BPH, pathologic grading as well as clinical stages of Pca.
  
  
  CONCLUSIONS
  b-FGF may be secreted from BPH and Pca tissues themselves, which is closely involved in the genesis and development of BPH and Pca.
authors.affiliation: Department of Urology, Fourth Military Medical University, Xi'an 710032, China. wangfuli98@163.com
authors.forename: Fu-li
authors.initials: FL
authors.lastname: Wang
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: Wei-jun
authors.initials: WJ
authors.lastname: Qin
authors.forename: Guo-jun
authors.initials: GJ
authors.lastname: Wu
authors.forename: Geng
authors.initials: G
authors.lastname: Zhang
authors.forename: Kai-nan
authors.initials: KN
authors.lastname: Li
mesh_terms: D000368:Aged; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000378:metabolism; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2