In vitro activities of beta-lactam antibiotics alone and in combination with sulbactam against Gram-negative bacteria.
The resistance rates of ampicillin/sulbactam 2:1 against imipenem-susceptible and -resistant Acinetobacter baumannii were 23.5 and 30%, respectively. Ceftazidime/sulbactam combination showed significant reduction of resistant rates against Enterobacter cloacae, A. baumannii, ESBL Klebsiella pneumoniae. MIC90 of cefoperazone against E. cloacae, Serratia marcescens, A. baumannii and ESBL K. pneumoniae were > 128 mg/l. Addition of sulbactam enhanced the antimicrobial activities significantly. When imipenem was combined with sulbactam, the resistant rates against imipenem-resistant A. baumanni were significantly reduced. Cefepime/sulbactam combination was active against imipenem-resistant A. baumanni. The resistance rates of aztreonam/sulbactam combination against E. cloacae, imipenem-sensitive and resistant A. baumannii, ESBL K. pneumoniae were lowered significantly. The cefotaxime/sulbactam combination showed a significant improvement of activities against E. cloacae, S. marcescens, A. baumannii and ESBL K. pneumoniae.
Wang
Fu-Der
FD
Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Lin
Mei-Lin
ML
Lee
Wen-Sen
WS
Liu
Cheng-Yi
CY
D040981:Acinetobacter baumannii / Q000187:drug effects; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001398:Aztreonam / Q000494:pharmacology; D000077723:Cefepime; D002438:Cefoperazone / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012706:Serratia marcescens / Q000187:drug effects; D013407:Sulbactam / Q000494:pharmacology*; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004338:Drug Combinations; D004791:Enzyme Inhibitors; D047090:beta-Lactams; D015378:Imipenem; D000667:Ampicillin; D002438:Cefoperazone; D000077723:Cefepime; D002442:Ceftazidime; D001398:Aztreonam; D002439:Cefotaxime; D013407:Sulbactam