title: [Insignificant carcinogenicity of chrysotile asbestos of the Ak-Dovurak deposits in Russia and its possible links].
abstract: Thrice intrapleural injection of 20 mg of dust of the chrysotile from the Ak-Dovurak deposit caused pleural mesothelioma in 10.7% of the rats, which was significantly less than that upon exposure to the chrysotiles from other deposits and amphiboles. The reason for the less carcinogenicity of this chrysotile is the structural features of the surface of its fibrils, namely, its high homogeneity and hence the lack of sites at which the electrically charged centers may be located.
authors.forename: L N
authors.initials: LN
authors.lastname: Pylev
authors.forename: L A
authors.initials: LA
authors.lastname: Vasil'eva
authors.forename: G A
authors.initials: GA
authors.lastname: Krinari
mesh_terms: D000818:Animals; D017632:Asbestos, Serpentine / Q000009:adverse effects*; D002391:Catchment Area, Health; D004391:Dust; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008223:Lymphoma / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced* / Q000473:pathology; D008906:Mining; D010997:Pleural Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D012426:Russia / Q000453:epidemiology; D013160:Splenic Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D017632:Asbestos, Serpentine; D004391:Dust