Successful elimination of an invasive Aspergillus nidulans lung infection by voriconazole after failure of a combination of caspofungin and liposomal amphotericin B in a boy with chronic granulomatous disease.
Chronic granulomatous disease is an inherited defect in host defense mechanisms mainly affecting neutrophil function. Pulmonary infection with Aspergillus nidulans in a child with chronic granulomatous disease could not be eliminated by a combination of caspofungin and liposomal amphotericin B. Voriconazole was successful in clearing the infection.
Rösen-Wolff
Angela
A
Department of Pediatrics, University Hospital Dresden, Dresden, Germany. roeslerj@rcs.urz.tu-dresden.de
Koch
Anne
A
Friedrich
Wilhelm
W
Hahn
Gabriele
G
Gahr
Manfred
M
Roesler
Joachim
J
D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D001233:Aspergillus nidulans / Q000187:drug effects / Q000302:isolation & purification*; D000077336:Caspofungin; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005500:Follow-Up Studies; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010455:Peptides / Q000008:administration & dosage; D010456:Peptides, Cyclic; D011743:Pyrimidines / Q000008:administration & dosage*; D018570:Risk Assessment; D016879:Salvage Therapy; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D000077336:Caspofungin; D065819:Voriconazole