title: Clinical implication of dermatopathic lymphadenopathy among Japanese: a report of 19 cases.
abstract: To clarify the clinicopathologic and immunohistochemical features of dermatopathic lymphadenopathy not associated with mycosis fungoides among Japanese, 19 patients were studied. Seventy-four percent of the patients were more than 50 years old (median; 63 years, mean 61 years). Systemic symptoms such as fever were recorded in 68% and multicentric lymphadenopathy was noted in 83% of patients. An association of autoimmune disease or positivity of autoantibodies was recorded in 6 patients. Five patients showed cutaneous hypersensitivity reactions to a drug. Histologically, in addition to the dermatopathic lymphadenopathy, numerous immunoblasts were observed in 2 cases and sheet-like proliferation of mature plasma cells in 3 cases. Various atypical or malignant lymphoproliferative disorders exhibiting immunologic abnormalities such as angioimmunoblastic T-cell lymphoma or autoimmune disease-associated lymphadenopathy frequently occur in middle-aged and elderly patients. At least some of the patients with dermatopathic lymphadenopathy should be clinicopathologically differentiated from these lymphoproliferative disorders.
authors.affiliation: Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hideaki
authors.initials: H
authors.lastname: Itoh
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamane
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Shimizu
authors.forename: Kayoko
authors.initials: K
authors.lastname: Murayama
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Shiro
authors.initials: S
authors.lastname: Sugihara
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Shunichi
authors.initials: S
authors.lastname: Shimano
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Masawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017809:Fatal Outcome; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology*