title: Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods.
abstract: The use of parallel synthesis techniques with statistical design of experiment (DoE) methods is a powerful combination for the optimization of chemical processes. Advances in parallel synthesis equipment and easy to use software for statistical DoE have fueled a growing acceptance of these techniques in the pharmaceutical industry. As drug candidate structures become more complex at the same time that development timelines are compressed, these enabling technologies promise to become more important in the future.
authors.affiliation: Argonaut Technologies, 1101 Chess Drive, Foster City, California 94404, USA. ogooding@argotech.com
authors.forename: Owen W
authors.initials: OW
authors.lastname: Gooding
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D004364:Pharmaceutical Preparations; D012107:Research Design; D012984:Software; D013223:Statistics as Topic; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
chemical_list: D004364:Pharmaceutical Preparations