Odontogenic ghost cell tumour with clear cell components: clear cell odontogenic ghost cell tumour?
A case of odontogenic ghost cell tumour (OGCT) with clear cell components was encountered in the mandible of a 63-year-old man. The tumour revealed ameloblastomatous-type epithelial components accompanied by clusters of ghost cells and dentinoid juxtaposed to the odontogenic epithelium. In addition, some areas of the tumour tissue showed sheets and islands of clear, glycogen containing epithelial cells, which were separated by a thin fibrous connective tissue stroma. Both ameloblastic and clear cells exhibited positive immunoreactivities for cytokeratin 19 and AE1/3. It is not known whether this tumour represents a clear cell change of a pre-existing OGCT or a separate and distinct neoplasm derived de novo from the odontogenic epithelium. This tumour was given the term 'clear cell OGCT' because it captures the clear cell components, which is one of the most prominent distinguishing features of the tumour.
Yoon
Jung Hoon
JH
Department of Oral Pathology, BK 21 Project, School of Dentistry, Chosun University, Gwangju, Korea. jhyoon@chosun.ac.kr
Ahn
Sang Gun
SG
Kim
Su Gwan
SG
Kim
Jin
J
D003937:Diagnosis, Differential; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008339:Mandibular Neoplasms / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009060:Mouth Floor / Q000473:pathology; D009808:Odontogenic Tumors / Q000737:chemistry / Q000473:pathology*
D007633:Keratins