Delayed salicylate toxicity at 35 hours without early manifestations following a single salicylate ingestion.
OBJECTIVE
To report a case of delayed toxicity following a single ingestion of aspirin, where the initial concentrations were nearly undetectable and the patient was completely asymptomatic for the first 35 hours.


METHODS
A 14-year-old white female was evaluated after a single ingestion of 120 tablets of aspirin 81 mg/tablet hours before arrival to the emergency department. She denied nausea, abdominal pain, tinnitus, or shortness of breath. She received one dose of activated charcoal. The first salicylate concentration (4 h after ingestion) was 1 mg/dL. At 35 hours, the patient became symptomatic (dizziness, tinnitus, epigastric discomfort). Her salicylate concentration at that time was 46 mg/dL. A second dose of activated charcoal was administered, and intravenous bicarbonate with potassium was started as a continuous infusion for 30 hours.


CONCLUSIONS
While delayed salicylate toxicity is well reported in the literature, no report was found regarding concentrations increasing to toxicity 35 hours after ingestion. The delayed aspirin absorption may be due to salicylate-induced pylorospasm or the formation of pharmacobezoars.


CONCLUSIONS
In cases with known salicylate ingestion, it is important to follow salicylate concentrations every 4 hours until they are steadily decreasing according to a 4-hour half-life and the patient shows no symptoms of salicylate intoxication.
Rivera
Wilfredo
W
Section of Toxicology, University of Texas Southwestern (UTSW) Emergency Medicine, Dallas, TX 75390-8579, USA. wilfredo.rivera@utsouthwestern.edu
Kleinschmidt
Kurt C
KC
Velez
Larissa I
LI
Shepherd
Greene
G
Keyes
Daniel C
DC
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood* / Q000506:poisoning*; D001241:Aspirin / Q000097:blood* / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin