The phenotype of sheep hemoglobins containing distinct alpha chains is influenced by beta chain genotype.
In sheep carrying simultaneously extra alpha-globin genes (triplications and quadruplications) and two alpha-chain allelic variants, a gradient of decreasing expression of the downstream genes was previously reported. We show here that in these sheep the proportions of the normal and variant Hbs reflect not only the position effect, but also the differential affinity of one of the alpha variants for the betaA and betaB allelic chains.
Vestri
Rita
R
Istituto di Fisiologia Umana, Università Cattolica del Sacro Cuore, Roma, Italia. rvestri@rm.unicatt.it
Massa
Adriana
A
D000818:Animals; D018628:Gene Dosage; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D011485:Protein Binding; D012756:Sheep / Q000235:genetics* / Q000378:metabolism; D013379:Substrate Specificity / Q000235:genetics
D005914:Globins