Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses.
In this study, for the first time, we investigated about the localization of VEGF-A, VEGFR-2 and Ang-2 in the choroid plexuses of the adult mouse by Western blot and immunohistochemistry. Results showed that VEGF-A stained epithelial cells, while anti-VEGFR-2 and -Ang-2 antibodies stained endothelial cells. These data suggest that Ang-2, converting blood vessels into a more plastic and immature phenotype, would provide more accessibility of VEGF-A to endothelial cells.
Nico
Beatrice
B
Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I-70124, Bari, Italy.
Mangieri
Domenica
D
Corsi
Patrizia
P
De Giorgis
Michela
M
Vacca
Angelo
A
Roncali
Luisa
L
Ribatti
Domenico
D
D000367:Age Factors; D042702:Angiopoietin-2 / Q000378:metabolism*; D000818:Animals; D002831:Choroid Plexus / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*
D042702:Angiopoietin-2; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2