Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis.
Gastric cancer remains the second leading cause of cancer deaths worldwide. Patients usually present late with local invasion or metastatic diseases. The present study investigated the expression level of liver-intestine cadherin (LI-cadherin) by RT-PCR and its correlation with clinicopathological data in 71 pairs of tumor and non-cancerous gastric mucosa. Protein expression level of LI-cadherin was determined by Western blotting and immunohistochemistry. The mRNA of LI-cadherin was highly expressed in tumor as compared to non-cancerous mucosa. Lymph node metastasis was significantly associated with the expression of LI-cadherin (p=0.038). On multivariate analysis, T staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis.
Ko
Samuel
S
Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong.
Chu
Kent-Man
KM
Luk
John M
JM
Wong
Bonnie W
BW
Yuen
Siu-Tsan
ST
Leung
Suet-Yi
SY
Wong
John
J
D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D015153:Blotting, Western; D015820:Cadherins; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000235:genetics*; D008297:Male; D026901:Membrane Transport Proteins; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
C490584:CDH17 protein, human; D015820:Cadherins; D002352:Carrier Proteins; D017931:DNA Primers; D026901:Membrane Transport Proteins; D012333:RNA, Messenger; C067802:intestinal peptide-proton cotransporter