title: Conjunctival melanoma metastasis diagnosed by sentinel lymph node biopsy.
abstract: OBJECTIVE
  Evaluate the use of sentinel lymph node biopsy (SLNB) in staging and directing treatment of patients with conjunctival malignancy.
  
  
  METHODS
  Retrospective, noncomparative, interventional case reports.
  
  
  METHODS
  Two patients with conjunctival melanoma underwent SLNB, which consisted of lymphoscintigraphy with injection of sulfur colloid technetium-99m. Lymphazurin blue was injected intraoperatively into the area of prior excision. The combination of a signal through the sulfur colloid technetium-99m and blue staining identified SLNs.
  
  
  RESULTS
  In both patients, the SLNs containing metastatic disease were identified and biopsies obtained, aiding staging and optimal therapy.
  
  
  CONCLUSIONS
  Sentinel lymph node biopsy has been recently reported as an aid in evaluating patients with periocular malignancies. These reports of patients with tumor-positive SLNs arising from the lymphatic metastasis of conjunctival malignancies underscore the utility of this important technique in evaluating patients with periocular malignancies.
authors.affiliation: Department of Surgery, Division of Plastic Surgery, Pennsylvania State College of Medicine, Milton S. Hershey Medical Center, Hershey, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Baroody
authors.forename: John B
authors.initials: JB
authors.lastname: Holds
authors.forename: Mimi S
authors.initials: MS
authors.lastname: Kokoska
authors.forename: James
authors.initials: J
authors.lastname: Boyd
mesh_terms: D000328:Adult; D003230:Conjunctival Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000556:secondary*; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012394:Rosaniline Dyes; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D012394:Rosaniline Dyes; C025484:iso-sulfan blue; D013671:Technetium Tc 99m Sulfur Colloid