[Correlation between activation-induced cytidine deaminase gene polymorphism and atopic asthma and plasma IgE in adult].
OBJECTIVE
To explore whether the activation-induced cytidine deaminase(AICDA) gene 8408 C/T polymorphism is related to adult atopic asthma and the level of plasma IgE.


METHODS
The polymorphism of AICDA gene was detected by PCR and restriction fragment length polymorphism (PCR-RFLP).


RESULTS
The frequencies of 8408T/T genotype had significant difference (P<0.05) between adult asthma patients and control group, while the frequencies of T allele between two groups were not significantly different. The total plasma IgE level in adult atopic asthma patients with 8408T/T genotype was higher than that in the patients with C/C and C/T genotypes(P<0.05).


CONCLUSIONS
The 8408 T/T genotype of AICDA is correlated with atopic asthma and total plasma IgE level in adult.
Cui
Tian-pen
TP
Institute of Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. tianpencui@hotmail.com
Wang
Lin
L
Jiang
Wei-chao
WC
Hu
Li-hua
LH
Wu
Jian-min
JM
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000201:enzymology* / Q000235:genetics / Q000276:immunology; D003564:Cytidine Deaminase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D007073:Immunoglobulin E; D003564:Cytidine Deaminase