[Aromatase inhibitors--is it a new opportunity in the treatment of infertility?].
Aromatase P-450 is a key enzyme in the production of estrogens, that is, the conversion of androstenedione and testosterone to estrone and estradiol. Aromatase is a good target for selective inhibition. New aromatase inhibitors provide a good opportunity for successful treatment during infertility management. They have a potential to replace clomiphene citrate (CC) as the first-line treatment for ovulation induction. Applying aromatase inhibitors during assisted reproduction followed: reducing the FSH dose needed to achieve optimum controlled ovarian hyperstimulation (COH); improving ovarian response to FSH in poor responders; terminating positive feedback loop and improving ovarian response to COH in infertile case with endometriosis; improving implantation rates in assisted reproduction technology (ART); reducing estrogen levels to reduce the risk of OHSS during COH.
Vladimirov
Ia K
IaK
Medical Center, St. Pantaleimon, Sofia.
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007246:Infertility / Q000188:drug therapy* / Q000201:enzymology; D010062:Ovulation Induction
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors