Ultrasound imaging distinguishes between normal and weak muscle.
OBJECTIVE
To determine whether real-time ultrasound imaging can provide quantitative data that distinguish pathologic from healthy muscle and that correlate with strength measures.


METHODS
Nonrandomized matched-pair, repeated-measures design.


METHODS
Ultrasound imaging laboratory, rehabilitation medicine department, government research hospital.


METHODS
Nine patients with stable active or inactive myositis, stratified into 3 groups based on their 10-point manual muscle test (MMT) scores, and 9 age- and gender-matched controls.


METHODS
Maximal isometric contraction of the rectus femoris muscle in 2 knee-flexion positions (60 degrees, 90 degrees ) during simultaneous ultrasound imaging and muscle force dynamometry.


METHODS
Changes of the rectus femoris muscle in horizontal (X) and vertical (Y) diameters between relaxed and contracted states, and muscle force measurements.


RESULTS
The X diameters decreased and the Y diameters increased during isometric contraction in all participants. For each group, average changes in cross-sectional diameters were consistently higher in controls than in patients. Patients with MMT less than 8 differed significantly from controls in both X and Y dimensions. A moderately strong correlation was found between muscle force and the Y diameter during contraction at 60 degrees (r =.78) and 90 degrees (r =.67) knee-flexion angles.


CONCLUSIONS
Ultrasonography provided a quantitative measure of change between relaxed and contracted state of muscle, which correlated with muscle force. Ultrasound identified significant differences in cross-sectional diameters between the myopathic and normal muscles sampled and may be useful for measuring muscle response to drug and exercise therapy.
Chi-Fishman
Gloria
G
Department of Rehabilitation Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Hicks
Jeanne E
JE
Cintas
Holly M
HM
Sonies
Barbara C
BC
Gerber
Lynn H
LH
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000000981:diagnostic imaging* / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000473:pathology; D009220:Myositis / Q000000981:diagnostic imaging*; D012044:Regression Analysis; D013848:Thigh; D014463:Ultrasonography