Arterial thrombosis due to minimal change glomerulopathy secondary to nonsteroidal anti-inflammatory drugs.
The authors report a 49-year-old woman who had been treated with diclofenac for her back pain. Nephrotic syndrome followed by occlusion of the right profound femoral and popliteal arteries occurred. Successful thrombectomy was performed. Another nonsteroidal anti-inflammatory drug (NSAID) was administered by injection during hospitalization. Renal biopsy showed minimal change glomerulopathy (MCG). Remission was delayed despite large-dose steroid administration. The delayed remission in this patient may be caused by impaired renal function and the possible effect of a second period of NSAID administration. The authors present the first case of femoral arterial thrombosis associated with nephrotic syndrome secondary to NSAID-associated MCG. Careful history-taking and physical examination may detect early causes and complications of nephrotic syndrome. Any rechallenge of NSAID should be avoided.
Huang
Jeng-Bin
JB
Division of Nephrology, Department of Medicine, Veterans General Hospital-Taipei and School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.
Yang
Wu-Chang
WC
Yang
An-Han
AH
Lee
Pui-Ching
PC
Lin
Chih-Ching
CC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology*; D015433:Glomerulonephritis, Membranous / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000473:pathology; D013927:Thrombosis / Q000139:chemically induced* / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal