Beta-globin gene cluster haplotypes linked to the betaS gene in western India.
The present survey, which involves 70 sickle cell anemia patients from Gujarat and Maharashtra revealed a high prevalence of the typical Arab-Indian haplotype (91.5 %). Six atypical haplotypes, including a Cameroon one were also found. Correlation of these various haplotypes with HbF expression was studied.
Mukherjee
Malay B
MB
Institute of Immunohaematology (ICMR), King Edward Memorial Hospital Campus, Parel, Mumbai, India.
Surve
Reema R
RR
Gangakhedkar
Raman R
RR
Ghosh
Kanjaksha
K
Colah
Roshan B
RB
Mohanty
Dipika
D
D000755:Anemia, Sickle Cell / Q000453:epidemiology* / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005914:Globins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006451:Hemoglobin, Sickle; D006801:Humans; D007194:India / Q000453:epidemiology*; D008297:Male; D005810:Multigene Family / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D006451:Hemoglobin, Sickle; D005914:Globins