Antifouling activity of simple synthetic isocyanides against larvae of the barnacle Balanus amphitrite.
Twelve simple linear isocyanides were synthesized and examined for antifouling activity and toxicity against cyprid larvae of the barnacle, Balanus amphitrite. Larval settlement was inhibited, with EC50 values of 0.046-1.90 microg ml(-1), and they were much less toxic (LD50 values ranging over 21.28 microg ml(-1)) than CuSO4 (EC50 0.30 microg ml(-1) and LD50 2.95 microg ml(-1)). The data indicate that simple linear isocyanides are promising non-toxic antifouling agents.
Nogata
Yasuyuki
Y
Abiko Research Laboratory Central Research Institute of Electric Power Industry 1646 Abiko Abiko-shi Chiba-ken 270-1194 Japan. noga@criepi.denken.or.jp
Kitano
Yoshikazu
Y
Yoshimura
Erina
E
Shinshima
Kyouji
K
Sakaguchi
Isamu
I
D000818:Animals; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D008386:Marine Biology; D013329:Structure-Activity Relationship; D001468:Thoracica / Q000187:drug effects* / Q000254:growth & development
D003486:Cyanides