Sex steroid hormones, growth and puberty in children with portal hypertension.
Perturbations in sex hormones occur in adults with liver disease; however, little is known about how liver disease affects hormone levels in children. To address this issue, we recruited 19 patients with portal hypertension and 21 non-hormone-deficient short children as controls. Serum sex hormones, sex hormone binding globulin (SHBG), IGF-I, IGFBP-3, gonadotropins, and thyroid hormones were measured; growth and pubertal status were recorded. There was no significant difference between groups for any of the sex hormones, SHBG, gonadotropins, or thyroid hormones. In contrast, IGF-I and IGFBP-3 were significantly lower among patients than controls, despite the fact that height SDS for the control group was significantly lower. We conclude from this cross-sectional study that children with portal hypertension do not have clinical evidence of growth failure or abnormal puberty, despite subtle changes in the growth axis.
Yuse-Gabriel
Cynthia M
CM
Division of Pediatric Endocrinology, Schneider Children 's Hospital of North Shore-Long Island Jewish Health System, New Hyde Park, NY, USA.
Shneider
Benjamin L
BL
Daum
Fredric
F
Yoon
Doug
D
Sison
Cristina P
CP
Speiser
Phyllis W
PW
D000293:Adolescent; D001827:Body Height; D016022:Case-Control Studies; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006128:Growth; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D007223:Infant; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D011627:Puberty; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D018972:Insulin-Like Growth Factor Binding Protein 3; D012738:Sex Hormone-Binding Globulin; D007334:Insulin-Like Growth Factor I