Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin.
A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin.
Chandrasekhar
S
S
Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in
Jagadeshwar
V
V
Narsihmulu
Ch
Ch
Sarangapani
M
M
Krishna
D R
DR
Vidyasagar
J
J
Vijay
Dolly
D
Sastry
G Narahari
GN
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; D014404:Tubulin; C109551:eleutherobin