title: Characteristics of erythritol and formulation of a novel coating with erythritol termed thin-layer sugarless coating.
abstract: The purpose of this study was to clarify the characteristics of erythritol and to develop the optimum basic formulation of a novel coating with erythritol termed thin-layer sugarless coating. Characteristics of erythritol were investigated compared with maltitol, mannitol, sorbitol, xylitol, and sucrose. Furthermore, the optimum basic formulation of thin-layer sugarless coating with erythritol was determined by coating glass beads. We selected a continuous spray mist method for thin-layer sugarless coating due to the formation of a thin sugarless coating layer by a simple method. We demonstrated that erythritol is a suitable coating material for thin-layer sugarless coating compared with maltitol, mannitol, sorbitol, xylitol, and sucrose because of its high water solubility, low hygroscopicity, instant crystallization, and low tackiness. We also demonstrated that thin-layer sugarless coating with erythritol can reduce coating time compared with the coating with maltitol or sucrose due to its characteristics. We developed the optimum basic formulation of thin-layer sugarless coating consists of erythritol, powdered acacia, and talc. We confirmed that a smooth coating layer and high coating efficiency were achieved using the formulation.
authors.affiliation: Healthcare Research Laboratories, Consumer Healthcare Company, Takeda Chemical, Industries, Ltd., 17-85, Jusohonmachi 2-Chome, Yodogawa-ku, Osaka 532-8686, Japan. Ohmori_Shinji@takeda.co.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohmori
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohno
authors.forename: Tadashi
authors.initials: T
authors.lastname: Makino
authors.forename: Toshio
authors.initials: T
authors.lastname: Kashihara
mesh_terms: D004355:Drug Stability; D004896:Erythritol / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D013499:Surface Properties; D013549:Sweetening Agents / Q000737:chemistry*; D013678:Technology, Pharmaceutical; D014867:Water / Q000737:chemistry
chemical_list: D005079:Excipients; D013549:Sweetening Agents; D014867:Water; D004896:Erythritol