[Expression of soluble intercellular adhesion molecule-1 in peri-implant sulcular fluid].
OBJECTIVE
To investigate the expression of soluble intercellular adhesion molecule-1(sICAM-1) in peri-implant sulcular fluid (PISF) of different health conditions.


METHODS
According to the health condition and plaque adhesion around dental implant, 51 titanium implants of 30 partly edentulous patients were divided into 3 groups: healthy group(H), gingivalis group(G) and peri-implantitis group(P). The clinical parameters included peri-implant pocket depth(PPD), gingival blood index (GBI), modified plaque index (mPLI) and sICAM-1. We used periopaper strips to collect PISF and an ELISA technique to measure the levels of sICAM-1.


RESULTS
The PPD levels of H, G and P groups were (2.64 +/- 1.00) mm, (3.65 +/- 0.60) mm and (4.39 +/- 1.46) mm respectively. The sICAM-1 levels in the three groups were (348.10 +/- 313.27) ng/ml, (898.30 +/- 501.14) ng/ml and (1149.36 +/- 1035.78) ng/ml. The sICAM-1 levels of PISF in the inflammatory groups and plaque adhesion groups were significantly higher than that in the healthy group and non-plaque adhesion group (P < 0.05). The PPD level in inflammatory groups was also significantly higher than that in healthy group.


CONCLUSIONS
Both the patients with peri-implantitis and the healthy controls showed the presence of sICAM-1 in PISF. Plaque accumulation might trigger the up-regulation of sICAM-1 levels, and the onset of inflammation would enhance the up-trend.
Xie
Zhi-gang
ZG
Department of Prosthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Huang
Ping
P
Liang
Xing
X
Chen
Ming
M
Yang
Xiao-yu
XY
D000328:Adult; D015921:Dental Implants / Q000009:adverse effects; D005260:Female; D005881:Gingiva / Q000737:chemistry / Q000473:pathology; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005891:Gingivitis / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000378:metabolism
D015921:Dental Implants; D018799:Intercellular Adhesion Molecule-1