[Hepatitis C virus infection and clinical outcome of kidney transplantation].
OBJECTIVE
To study the influence of hepatitis C virus (HCV) infection on the clinical outcome of kidney transplantation.


METHODS
The recipient/graft survival, the incidence of acute/chronic rejection and cause of death in 86 HCV-infected recipients of renal transplantation were compared with those in another 86 recipients without HCV infection.


RESULTS
HCV-infected recipients had significantly shorter 5-year survival (74.4%) than those without HCV infection (87.2%, P<0.01). The 1-year (94.2%/90.7% vs 96.8%/96.0%) and 3-year recipient/graft survival rates (88.4%/79.1% vs 90.7%/87.2%), the incidence of acute/chronic rejection (31.3% vs 21.2%, and 12.5% vs 6.5%) and the 5-year graft survival (73.3%/81.4%) were comparable between the two groups (P>0.05). Hepatic disease was identified as the primary cause of mortality.


CONCLUSIONS
HCV infection may affect the long-term survival of the recipients with kidney transplantation, and therefore should be considered as a relative contraindication of kidney transplantation.
Yu
Li-xin
LX
Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. liuxy@fimmu.com
Wang
Zhi-peng
ZP
Fu
Shao-jie
SJ
Wang
Yi-bin
YB
Du
Chu-fu
CF
Xu
Jian
J
Deng
Wen-feng
WF
D000328:Adult; D000368:Aged; D005260:Female; D006085:Graft Survival; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D007166:Immunosuppressive Agents