[Metallothionein content in tissue and neoplasms of mice under cadmium chloride administration and gamma irradiation. Increased radioresistance in mice with elevated level of metallothionein].
It was confirmed that the survival of gamma-exposed mice became higher after preliminarily subcutaneous injections of cadmium chloride. It is supposed that radioresistance of mice is connected with the induction of metallothionein proteins by cadmium chloride.
Smoryzanova
O A
OA
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk.
Synzynys
B I
BI
Danilin
I A
IA
Baranova
O A
OA
D000818:Animals; D019256:Cadmium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005720:Gamma Rays; D007279:Injections, Subcutaneous; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016019:Survival Analysis; D013997:Time Factors; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D008668:Metallothionein; D019256:Cadmium Chloride