title: Macular burn after transpupillary thermotherapy for occult choroidal neovascularization.
abstract: OBJECTIVE
  To report a case of severe macular burn as a complication of transpupillary thermotherapy treatment for occult choroidal neovascularization.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 65-year-old man developed a severe macular burn following transpupillary thermotherapy treatment.
  
  
  RESULTS
  Before treatment, fluorescein angiography and indocyanine green angiography showed a progressive, ill-defined leakage corresponding to the presence of occult choroidal neovascularization. One month after treatment, fundus examination disclosed macular atrophy. The early phases of fluorescein angiography and indocyanine green angiography showed that the macular choroidal filling time had worsened dramatically. At the late phase of indocyanine green angiography, the initial hyperfluorescence of choroidal neovascularization was replaced by a persistent, markedly hypofluorescent area.
  
  
  CONCLUSIONS
  Prolonged choroidal filling may be a risk factor for macular burn and choroidal occlusion after transpupillary thermotherapy. In such cases, we suggest that transpupillary thermotherapy should be considered with caution and, when applied, that its intensity should be reduced.
authors.affiliation: Department of Ophthalmology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France. nathanael_benhamou@yahoo.fr
authors.forename: Nathanael
authors.initials: N
authors.lastname: Benhamou
authors.forename: Salomon Y
authors.initials: SY
authors.lastname: Cohen
authors.forename: Ali
authors.initials: A
authors.lastname: Erginay
authors.forename: Joel
authors.initials: J
authors.lastname: Uzzan
authors.forename: Gerard
authors.initials: G
authors.lastname: Brasseur
authors.forename: Isaac
authors.initials: I
authors.lastname: Avni
authors.forename: Alain
authors.initials: A
authors.lastname: Gaudric
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000628:therapy*; D005126:Eye Burns / Q000175:diagnosis / Q000209:etiology*; D005451:Fluorescein Angiography; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007208:Indocyanine Green; D008266:Macula Lutea / Q000293:injuries* / Q000473:pathology; D008297:Male; D011680:Pupil
chemical_list: D007208:Indocyanine Green