Fetal cortical allografts project massively through the adult cortex.
Allogeneic embryonic CNS tissue grafts placed in the mature brain are classically considered to lack significant long-range efferents. This problem was reexamined using 'green' cells from mice expressing ubiquitously an 'enhanced' green fluorescent protein as an alternative to classical tract tracing methods. The present study shows that fetal cortical neurons (E15; occipital origin) grafted in the occipitoparietal region of the adult cortex project massively throughout ipsilateral telencephalic structures. Two out of the nine grafted subjects had additional but sparse efferents in the visual thalamus, superior colliculus and pons.
Gaillard
F
F
UMR 6558 CNRS, Cortical Development Group, Faculty of Sciences, 40 avenue du Recteur Pineau, F-86022 Poitiers, France. frederic.gaillard@univ-poitiers.fr
Domballe
L
L
Gaillard
A
A
D000818:Animals; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002540:Cerebral Cortex / Q000637:transplantation*; D004622:Embryo, Mammalian; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D006085:Graft Survival / Q000502:physiology*; D049452:Green Fluorescent Proteins; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008164:Luminescent Proteins; D051379:Mice; D018613:Microscopy, Confocal; D014184:Transplantation, Homologous
D008164:Luminescent Proteins; D049452:Green Fluorescent Proteins