Biological evaluation of substituted quinolines.
Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 microM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs.
Franck
Xavier
X
Laboratoire de Pharmacognosie (associé au CNRS-BioCIS), Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.
Fournet
Alain
A
Prina
Eric
E
Mahieux
Renaud
R
Hocquemiller
Reynald
R
Figadère
Bruno
B
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D005069:Evaluation Studies as Topic; D015490:HTLV-I Infections; D007891:Leishmania / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*
D000977:Antiparasitic Agents; D011804:Quinolines