title: Metaplastic ossification in a cutaneous pyogenic granuloma: a case report.
abstract: Cutaneous ossification may occur in association with a variety of cutaneous neoplasms and inflammatory conditions, such as pilomatricomas, basal cell carcinomas, nevi, chondroid syringomas, venous stasis, and scars. However, it has rarely been reported in pyogenic granuloma, a relatively common benign vascular tumor of the skin and mucous membranes. We herein presented a rare case of cutaneous pyogenic granuloma with ectopic ossification on the big toe of a 37-year-old man, with high recurrence despite repeated CO2 laser ablations. We propose the hypothesis that vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) play pathologic roles in the development of ectopic bone formation in pyogenic granuloma.
authors.affiliation: Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Korea.
authors.forename: Eun Sung
authors.initials: ES
authors.lastname: Kim
authors.forename: Kyoung Jin
authors.initials: KJ
authors.lastname: Kim
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Chang
authors.forename: Mi Woo
authors.initials: MW
authors.lastname: Lee
authors.forename: Jee Ho
authors.initials: JH
authors.lastname: Choi
authors.forename: Kee Chan
authors.initials: KC
authors.lastname: Moon
authors.forename: Jai Kyoung
authors.initials: JK
authors.lastname: Koh
mesh_terms: D000328:Adult; D002424:Caustics / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D017789:Granuloma, Pyogenic / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D006801:Humans; D053685:Laser Therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D009999:Ossification, Heterotopic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D014034:Toes; D014238:Trichloroacetic Acid / Q000008:administration & dosage
chemical_list: D002424:Caustics; D014238:Trichloroacetic Acid