Immunotoxins and other conjugates: pre-clinical studies.
A wide variety of conjugates containing RIPs, of either chemical or recombinant type, have been made and tested against dangerous cells in vitro and in animal models. Many of these pre-clinical studies will be reviewed here dividing them on the basis of the target cell and the surface molecule specifically recognized.
Bolognesi
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Department of Experimental Pathology, University of Bologna, Italy. andrea.bolognesi@unibo.it
Polito
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D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006801:Humans; D000922:Immunotoxins / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity*; D011506:Proteins / Q000009:adverse effects / Q000276:immunology / Q000494:pharmacology / Q000633:toxicity*; D012270:Ribosomes / Q000187:drug effects; D012680:Sensitivity and Specificity
D000970:Antineoplastic Agents; D000922:Immunotoxins; D011506:Proteins