The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons.
This review summarizes the mechanisms of neurotoxicity associated to androgen receptor containing an elongated polyglutamine tract responsible for motor neuronal cell death.
Poletti
Angelo
A
Institute of Endocrinology, Centre of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy. Angelo.Poletti@unimi.it
D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000737:chemistry / Q000378:metabolism*; D020966:Muscular Disorders, Atrophic / Q000378:metabolism*; D009154:Mutation; D009498:Neurotoxins / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
D009498:Neurotoxins; D010455:Peptides; D011944:Receptors, Androgen; C097188:polyglutamine