title: Biological evaluation of substituted quinolines.
abstract: Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 microM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs.
authors.affiliation: Laboratoire de Pharmacognosie (associé au CNRS-BioCIS), Faculté de Pharmacie, Université de Paris-Sud, rue J.B. Clément, 92296 Châtenay-Malabry, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Franck
authors.forename: Alain
authors.initials: A
authors.lastname: Fournet
authors.forename: Eric
authors.initials: E
authors.lastname: Prina
authors.forename: Renaud
authors.initials: R
authors.lastname: Mahieux
authors.forename: Reynald
authors.initials: R
authors.lastname: Hocquemiller
authors.forename: Bruno
authors.initials: B
authors.lastname: Figadère
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D002472:Cell Transformation, Viral; D005069:Evaluation Studies as Topic; D015490:HTLV-I Infections; D007891:Leishmania / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects*
chemical_list: D000977:Antiparasitic Agents; D011804:Quinolines