title: Perinatal outcome in women with severe pregnancy complications and multiple thrombophilias.
abstract: Hypercoagulability leading to placental thrombosis has been implicated in severe pregnancy complications. We compared the perinatal outcome in women with severe preeclampsia, intrauterine growth retardation (IUGR) and severe abruptio placentae and multiple acquired and inherited thrombophilias (study group, n=22) to matched women with similar complications and single thrombophilia (control group, n=22). Gestational age at delivery and birth weight were significantly lower in the study group compared to the control group (p<0.01) and among the study women with severe preeclampsia and IUGR. Severe pregnancy complications may occur earlier during pregnancy and more seriously affect perinatal outcome in women with multiple thrombophilias.
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. Tmcobgyn@tasmc.health.gov.il
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Kupferminc
authors.forename: Elyahu
authors.initials: E
authors.lastname: Rimon
authors.forename: Jessica
authors.initials: J
authors.lastname: Ascher-Landsberg
authors.forename: Joseph B
authors.initials: JB
authors.lastname: Lessing
authors.forename: Ariel
authors.initials: A
authors.lastname: Many
mesh_terms: D000037:Abruptio Placentae / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007557:Israel / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D011256:Pregnancy Outcome; D012720:Severity of Illness Index; D019851:Thrombophilia / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology