Molecular basis of the evolution of drug resistance: potential role of the transient state during infection/drug treatment.
Transient period represents the time window between the exposure and response to the given stimuli inflicting the stress on the host. However, this time window is unlikely to engage in variety of signaling to culminate drastic impact on the host cell rather it is evolutionary in its sense implying a slow process. But it is reasonable to speculate that most significant signals are initiated at this time, and first responder will confer required adaptive features on the host cells. This alteration would be followed by amplification of appropriate adaptative signals in the successive generation(s), thus conferring the increased adaptability to given stress.
Kannan
Subburaj
S
Medical Branch, University of Texas at Galveston, P.O. Box 25056, Galveston, TX 77550, USA. skannan22@hotmail.com
D000222:Adaptation, Physiological / Q000187:drug effects / Q000235:genetics / Q000276:immunology; D000818:Animals; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics*; D004351:Drug Resistance / Q000187:drug effects / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000235:genetics*; D007239:Infections / Q000188:drug therapy / Q000235:genetics*