title: A 10-year comparison of endogenous endophthalmitis outcomes: an east Asian experience with Klebsiella pneumoniae infection.
abstract: OBJECTIVE
  To evaluate the infection sources and causative organisms in cases of endogenous endophthalmitis and review the outcomes for patients with Klebsiella pneumoniae infection during a 10-year period.
  
  
  METHODS
  All cases of endogenous endophthalmitis treated at one Taiwanese hospital from July 1992 to June 2002 were retrospectively reviewed (n = 74; 86 eyes). The study was divided into two 5-year periods, with patients stratified into Group F or Group L according to onset date within the first or last of these periods, respectively. The outcomes of cases of K. pneumoniae infection in Group L (21 eyes) and Group F (32 eyes) were compared.
  
  
  RESULTS
  The major source of infection (liver abscess) and the causative organism (K. pneumoniae) did not change throughout the 10-year review period; however, outcomes for Group L appeared superior. The interval from onset of ocular symptoms to ophthalmic consultation was shorter for Group L; however, a statistically significant difference was not demonstrated by between-group comparison. Patients with good final vision typically had good initial vision in cases of K. pneumoniae infection.
  
  
  CONCLUSIONS
  The authors' experience with endogenous endophthalmitis has confirmed the findings of analogous East Asian studies, with liver abscess as the major source of infection and K. pneumoniae as the causative organism. Superior outcome may be achieved with more comprehensive and collaborative management, ideally through the combined efforts of multiple medical subspecialties.
authors.affiliation: Department of Ophthalmology, Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan. d2767@adm.cgmh.org.tw
authors.forename: Yung-Jen
authors.initials: YJ
authors.lastname: Chen
authors.forename: Hsi-Kung
authors.initials: HK
authors.lastname: Kuo
authors.forename: Pei-Chang
authors.initials: PC
authors.lastname: Wu
authors.forename: Min-Lun
authors.initials: ML
authors.lastname: Kuo
authors.forename: Hsih-Hao
authors.initials: HH
authors.lastname: Tsai
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Liu
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D009877:Endophthalmitis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008100:Liver Abscess / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013624:Taiwan / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents