title: In vitro screening of leishmanicidal activity in myanmar timber extracts.
abstract: Seventy-five Myanmar timber extracts belonging to 27 families were examined for their leishmanicidal activities. Some timber extracts had significant leishmanicidal activity, especially extracts of Millettia pendula, which exhibited the most potent activity (MLC 3.1 microg/ml, MIC 1.6 microg/ml). Other timber extracts showing potent activity included those from Cedrela serrata, Cedrela toona, Cordia fragrantissima, Calophyllum kunstleri, Dalbergia cultrate, Grevillea robusta, Haplophragma adenophyllum, Michelia champaca, and Tectona grandis. From a literature search for reports on the chemical constituents of these plants, most constituents were found to be quinone derivatives or other compounds with unsaturated carbonyl groups.
authors.affiliation: Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences, Hachimandai, Japan.
authors.forename: Marii
authors.initials: M
authors.lastname: Takahashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fuchino
authors.forename: Motoyoshi
authors.initials: M
authors.lastname: Satake
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Agatsuma
authors.forename: Setsuko
authors.initials: S
authors.lastname: Sekita
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D018320:Leishmania major / Q000187:drug effects* / Q000254:growth & development; D002052:Myanmar; D024301:Plant Bark; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D010936:Plant Extracts