Multi-nuclear platinum complexes encapsulated in cucurbit[n]uril as an approach to reduce toxicity in cancer treatment.
The dinuclear platinum complex trans-[[Pt(NH(3))(2)Cl](2)micro-dpzm](2+)(di-Pt) binds inside cucurbit[7]uril with slow exchange kinetics which does not significantly affect the cytotoxicity of the dinuclear complex but reactivity at the platinum centre is reduced.
Wheate
Nial J
NJ
School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Australian Defence Force Academy, Northcott Drive, Campbell, ACT, 2600, Australia.
Day
Anthony I
AI
Blanch
Rodney J
RJ
Arnold
Alan P
AP
Cullinane
Carleen
C
Collins
J Grant
JG
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007700:Kinetics; D007938:Leukemia / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D014407:Tumor Cells, Cultured; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D004273:DNA, Neoplasm; D007093:Imidazoles; D009944:Organoplatinum Compounds; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils