Long-term results of bilateral pallidal stimulation in Parkinson's disease.
We followed up 11 patients for up to 5 years after bilateral pallidal deep brain stimulation for advanced Parkinson's disease. Dyskinesias remained significantly reduced until the last assessment. The initial improvement of off-period motor symptoms and fluctuations, however, was not sustained and gradually declined. Beneficial effects of pallidal deep brain stimulation on activities of daily living in the on- and off-period were lost after the first year. Replacement of pallidal electrodes into the subthalamic nucleus in four patients could restore the initial benefit of deep brain stimulation and allowed a significant reduction of dopaminergic drug therapy.
Volkmann
Jens
J
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Cologne, Germany. j.volkmann@neurologie.uni-kiel.de
Allert
Niels
N
Voges
Jürgen
J
Sturm
Volker
V
Schnitzler
Alfons
A
Freund
Hans-Joachim
HJ
D000203:Activities of Daily Living; D000328:Adult; D020820:Dyskinesias / Q000503:physiopathology / Q000628:therapy; D004558:Electric Stimulation / Q000379:methods; D004599:Electric Stimulation Therapy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005917:Globus Pallidus / Q000502:physiology / Q000528:radiation effects* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000628:therapy*; D011446:Prospective Studies; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000528:radiation effects / Q000601:surgery; D013995:Time; D016896:Treatment Outcome