Drosophila gustatory receptors: from gene identification to functional expression.
Recent years have seen long-awaited progress in understanding of the molecular mechanisms of taste perception in insects. The breakthrough came in the early 2000 with the identification of a novel family of candidate gustatory receptor (Gr) genes in the first release of the Drosophila melanogaster genome sequence. The 60 Gr genes are expressed in the subsets of gustatory neurons in the fly's taste organs and, without exception, encode heptahelical G protein-coupled receptors (GPCRs). Here I review our current knowledge about Gr genes and their products focusing on the newly emerging information regarding the function of the Gr-encoded proteins.
Chyb
Sylwester
S
Laboratory of Molecular Physiology, Imperial College London, Wye Campus, Kent TN25 5AH, UK. s.chyb@imperial.ac.uk
D000818:Animals; D002628:Chemoreceptor Cells / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D013649:Taste / Q000235:genetics*
D029721:Drosophila Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C405956:gustatory receptor, Drosophila