[The application of cross-linked hyaluronate hydrogel to trabeculectomy].
OBJECTIVE
We investigated the possibility of applying cross-linked hyaluronate hydrogel (HA gel) during trabeculectomy in rabbit eyes.


METHODS
1. We injected 0.9% salt solution (n = 3), Opegan-HI (n = 3), or HA gel (n = 3) into the subconjunctiva to make a follicle, and investigated its size. 2. After making a limbal-based conjunctival flap and a scleral flap, we injected HA gel or 0.9% salt solution into the subconjunctiva of rabbit eyes and sutured each flap (n = 4 each). Three weeks after the operation, we incised the conjunctiva and investigated the case of peeling away the conjunctival flap or the scleral flap. 3. We performed trabeculectomy with and without subconjunctival HA gel (n = 7 and 6, respectively), and compared the reduction of intraocular pressure between the two groups.


RESULTS
The results showed that the formation of the follicle was excellent and it was easy to peel away the adhesion. The reduction of intraocular pressure was statistically significant 4 weeks after the operation in which the HA gel was used.


CONCLUSIONS
It could be useful to apply HA gel in trabeculectomy to prevent adhesion.
Shoji
Nobuyuki
N
Department of Orthoptics and Visual Science, Kitasato University, School of Allied Health Science, 1-15-1 Kitasato, Sagamihara 228-8555, Japan.
Shimizu
Kimiya
K
Takahashi
Katsuya
K
Nemoto
Rika
R
Kawai
Hiromi
H
Tomioka
Toshiya
T
D000818:Animals; D005128:Eye Diseases / Q000517:prevention & control; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000494:pharmacology; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage* / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control; D014130:Trabeculectomy
D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D006820:Hyaluronic Acid