title: Synthesis and antitumor activity of 20-O-linked nitrogen-based camptothecin ester derivatives.
abstract: A series of nitrogen-based 20S-hydroxyl camptothecin ester derivatives were prepared. 3-Aminopropionate of camptothecin was found more cytotoxic in vitro on several human tumor cell lines than 3-amidopropionate of camptothecin. Ester 16 showed best antitumor activity in vivo and in vitro in all esters we prepared.
authors.affiliation: School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008, China.
authors.forename: Cun-ying
authors.initials: CY
authors.lastname: Wang
authors.forename: Xian-dao
authors.initials: XD
authors.lastname: Pan
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Zhao-di
authors.initials: ZD
authors.lastname: Fu
authors.forename: Xian-yong
authors.initials: XY
authors.lastname: Wei
authors.forename: Li-Xi
authors.initials: LX
authors.lastname: Yang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D004952:Esters / Q000737:chemistry*; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D009584:Nitrogen; D002166:Camptothecin