[Association of apoE polymorphism and treatment outcome in patients with traumatic brain injury].
A number of papers published in recent years indicate the importance of the apolipoprotein E gene (apoE) for the outcome of traumatic brain injury [TBI]. A majority of publications suggest that the presence of an epsilon 4 allele is associated with an unfavorable long-term outcome. A hypothesis has been recently posed that this phenomenon may be related to an increased risk of traumatic hypoxic brain damage or post-traumatic ischemic complications. The study group consisted of 95 consecutive TBI patients treated in the years 2000-2001 in the Neurotraumatology Clinic. The presence of apoE epsilon 4 was found in 16 cases. In the statistical analysis relationship was sought between the patient's age and state of consciousness at admission as assessed using the Glasgow Coma Scale, on the one hand, and on the other hand, treatment outcome at 6 months from injury, in patients differing in respect of apoE epsilon 4 presence. Although the number of apoE-negative patients was nearly five times as large as that of the apoE-positive, regression coefficients in both groups were statistically significant. The obtained results indicate that the presence of apoE epsilon 4 contributes to a less favorable clinical TBI outcome than the absence of this allele.
Krupa
Mariusz
M
Kliniki Neurotraumatologii CMUJ w Krakowie. krupa@neuro.cm-uj.krakow.pl
Moskała
Marek
M
Gościński
Igor
I
Traczewski
Wojciech
W
Polak
Jarosław
J
Sado
Małgorzata
M
D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D001930:Brain Injuries / Q000235:genetics* / Q000628:therapy*; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E