Specific inhibition effects of N-pentafluorobenzyl-1-deoxynojirimycin on human CD4+ T cells.
We first synthesized N-pentafluorobenzyl-1-deoxynojirimycin (5F-DNM), one new derivative of 1-deoxynojirimycin (DNM). Effects on human peripheral blood mononuclear cells (PMBC) and secretion of cytokines from human PBMC by 5F-DNM were investigated. It was first found that 5F-DNM remarkably inhibited the secretion of interleukin-4 (IL-4) and had a specific inhibition on the expression of CD4 molecules. 5F-DNM, much less toxic than cyclosporin A, might be used as a new candidate of immunosuppressant for specifically treating Th2-mediated immune diseases.
Zhang
Xiao-Lian
XL
Department of Immunology, College of Medicine, Wuhan University, Wuhan 430071, PR China. zhangxl65@hotmail.com
Liu
Min
M
Xie
Peng
P
Wan
Shuhui
S
Tao Ye
Jia
J
Zhou
Xiang
X
Wu
Jianguo
J
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016572:Cyclosporine / Q000627:therapeutic use; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D015847:Interleukin-4 / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D005464:Fluorobenzenes; D005466:Fluorocarbons
D017485:1-Deoxynojirimycin; D001593:Benzyl Compounds; D016572:Cyclosporine; D016207:Cytokines; D007166:Immunosuppressive Agents; D015847:Interleukin-4; C495827:N-pentafluorobenzyl-1-deoxynojirimycin; D005464:Fluorobenzenes; D005466:Fluorocarbons