title: [Present-day Clinical characteristics of scarlatina].
abstract: OBJECTIVE
  To study present-day clinical manifestations of scarlatina.
  
  
  METHODS
  The authors have reviewed 138 case histories of children with scarlatina treated outpatiently and 51 case histories of hospitalized scarlatina children as well as social and age characteristics of 1657 children and 108 adults hospitalized in the infectious hospital N 1 in 1962-2001. Official data on scarlatina morbidity in Moscow and Russia for 1991-2001 are presented. Antibiotic sensitivity of 414 cultures of group A streptococci (GAS) isolated in 1987-1995 and 1996-2001 was investigated.
  
  
  RESULTS
  Overall and seasonal scarlatina morbidities in 7-14-year-olds appeared to rise significantly. In the majority of cases scarlatina took a mild course but in the adults clinical picture of the disease was rather severe. GAS demonstrated high sensitivity (about 100%) to betalactamic antibiotics. The percentage of erythromycin-resistant streptococcal cultures increased more than 9-fold and reached 1.9% (1996-2001). There is a marked trend to a proportional increase of GAS cultures resistant to tetracycline and gentamycin.
  
  
  CONCLUSIONS
  Recently, changes have occurred in scarlatina epidemiological and clinical features. Different sensitivity of GAS to antibiotics must be taken into consideration for prescription of etiotropic treatment and prevention of scarlatina at jobs.
authors.forename: V I
authors.initials: VI
authors.lastname: Pokrovsiĭ
authors.forename: N I
authors.initials: NI
authors.lastname: Briko
authors.forename: N A
authors.initials: NA
authors.lastname: Malyshev
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D002648:Child; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009031:Moscow / Q000453:epidemiology; D012189:Retrospective Studies; D012541:Scarlet Fever / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology*; D013297:Streptococcus pyogenes
chemical_list: D000900:Anti-Bacterial Agents