CLIP-170 family members: a motor-driven ride to microtubule plus ends.
CLIP-170 family proteins regulate microtubule plus end dynamics. Two reports published in this issue of Developmental Cell show that Bik1 and tip1p, the CLIP-170-like proteins of budding and fission yeast, are carried to microtubule plus ends by kinesin motor proteins. These findings indicate a complex interplay between microtubule-associated proteins and suggest a novel mechanism by which kinesin proteins stabilize microtubules.
Maekawa
Hiromi
H
The Paterson Institute for Cancer Research, Wilmslow Road, Manchester M20 4BX, United Kingdom.
Schiebel
Elmar
E
D002352:Carrier Proteins / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006360:Heat-Shock Proteins; D007381:Intermediate Filament Proteins; D016547:Kinesins / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000378:metabolism; D009363:Neoplasm Proteins; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D004718:Saccharomycetales / Q000378:metabolism* / Q000648:ultrastructure; D012568:Schizosaccharomyces / Q000378:metabolism* / Q000648:ultrastructure; D029702:Schizosaccharomyces pombe Proteins
D002352:Carrier Proteins; D006023:Glycoproteins; D006360:Heat-Shock Proteins; D007381:Intermediate Filament Proteins; D008869:Microtubule-Associated Proteins; D020409:Molecular Motor Proteins; D009363:Neoplasm Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C114142:tip1 protein, S pombe; C076744:cytoplasmic linker protein 170; D016547:Kinesins