title: Wavefront analysis of higher order aberrations in dry eye patients.
abstract: OBJECTIVE
  To compare ocular wavefront aberrations of normal and dry eyes and to describe the characteristics of higher order aberration in dry eyes.
  
  
  METHODS
  Wavefront analysis of higher order ocular aberrations (total S3+4+5, spherical-like S4, coma-like S3+5) was performed with a Hartmann-Shack aberrometer in 20 dry eyes and 20 normal control eyes.
  
  
  RESULTS
  Total, spherical-like, and coma-like aberrations were significantly greater in dry eyes than in normal controls (P < .01) both for a 4-mm (total S3+4: factor of 2.58; spherical S4: factor of 2.50; coma S3: factor of 2.70) and 6-mm-diameter pupil (S3+4+5: factor of 2.29, S4: x2.53, and S3+5: factor of 2.40).
  
  
  CONCLUSIONS
  Eyes of dry eye patients showed greater optical aberrations compared with normal control eyes. Increase in higher order aberrations in dry eyes resulted from increased tear film irregularity.
authors.affiliation: Research, Development and Innovation Department, Ophthalmologic Institute of Alicante, School of Medicine, University Miguel Hernández, Spain. roberto.montes@uv.es
authors.forename: Robert
authors.initials: R
authors.lastname: Montés-Micó
authors.forename: Araceli
authors.initials: A
authors.lastname: Cáliz
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alió
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003316:Corneal Diseases / Q000503:physiopathology*; D019781:Corneal Topography; D015352:Dry Eye Syndromes / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D013666:Tears / Q000502:physiology; D014786:Vision Disorders / Q000503:physiopathology*