title: Novel tissue and cell type-specific gene/drug delivery system using surface engineered hepatitis B virus nano-particles.
abstract: The hepatitis B virus (HBV) surface antigen (HBsAg) L particle is a hollow nano-scale particle. HBsAg L particles have many properties that make them useful for in vivo gene transfer vectors and drug delivery systems. Gene therapy so far has required the in vivo pinpoint delivery of genetic materials into the target organs and cells. Gene transfer by HBsAg L particles might be an attractive method, since their tropism is the same as that of HBV. The HBsAg L particles are able to deliver therapeutic payloads with high specificity to human hepatocytes. In addition, the specificity of L particle can be altered by displaying various cell-binding molecules on the surface. Our results indicate that the L particle is suitable for a cell- and tissue-specific gene/drug transfer vector. In this review, we discuss HBsAg L particles as a gene/drug transfer vector and its potential for the treatment of infectious diseases.
authors.affiliation: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka, 567-0047, Japan.
authors.forename: Tadanori
authors.initials: T
authors.lastname: Yamada
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ueda
authors.forename: Masaharu
authors.initials: M
authors.lastname: Seno
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kondo
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Tanizawa
authors.forename: Shun'ichi
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D015316:Genetic Therapy; D005822:Genetic Vectors; D006509:Hepatitis B / Q000235:genetics / Q000628:therapy; D006514:Hepatitis B Surface Antigens / Q000235:genetics*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage* / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics*; D006526:Hepatitis C / Q000235:genetics / Q000628:therapy; D006801:Humans; D036103:Nanotechnology; D010316:Particle Size
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines