title: Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients.
abstract: A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P < 0.05).
authors.affiliation: Department of Medical Microbiology, Immunobiology, and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Asrat
authors.forename: Ingrid
authors.initials: I
authors.lastname: Nilsson
authors.forename: Yohannes
authors.initials: Y
authors.lastname: Mengistu
authors.forename: Endale
authors.initials: E
authors.lastname: Kassa
authors.forename: Senait
authors.initials: S
authors.lastname: Ashenafi
authors.forename: Kiros
authors.initials: K
authors.lastname: Ayenew
authors.forename: Torkel
authors.initials: T
authors.lastname: Wadström
authors.forename: Waleed
authors.initials: W
authors.lastname: Abu-Al-Soud
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D004415:Dyspepsia / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005838:Genotype; D016480:Helicobacter pylori / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori