title: Retinal nerve fiber loss in high- and normal-tension glaucoma by optical coherence tomography.
abstract: OBJECTIVE
  To compare the pattern of retinal nerve fiber layer (RNFL) damages in high-tension and normal-tension primary chronic open-angle glaucoma using optical coherence tomography (OCT).
  
  
  METHODS
  Age- and refractive error-matched patients with normal-tension glaucoma (NTG) (n = 38) and high-tension glaucoma (HTG) (n = 48) and normal subjects (n = 48) were recruited. All subjects underwent complete eye examinations and OCT RNFL assessments.
  
  
  RESULTS
  No statistically significant difference was found between eyes with HTG and NTG for any OCT RNFL thickness parameters (p > 0.05). Inferotemporal thickness values were significantly lower than the superotemporal thickness values in both glaucoma groups (p < 0.001), but no difference was observed in the normal group. Compared with the results from normal subjects, several OCT parameters, including average, superior, inferior, inferotemporal, and superotemporal values, were significantly lower in patients with HTG and NTG (p < 0.01).
  
  
  CONCLUSIONS
  A mixture of diffuse RNFL damage (superotemporal and inferotemporal regions) and local damage in inferotemporal region was observed in patients with HTG and NTG, suggesting that HTG and NTG may undergo same pathological process.
authors.affiliation: Mr. and Mrs. Tung Kay Fung Ophthalmic Laser Centre, Hong Kong Adventist Hospital, Hong Kong, China. akhmok@hkah.org.hk
authors.forename: Kwok Hei
authors.initials: KH
authors.lastname: Mok
authors.forename: Vincent Wing-Hong
authors.initials: VW
authors.lastname: Lee
authors.forename: Kwok Fai
authors.initials: KF
authors.lastname: So
mesh_terms: D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular