title: [Significance of detecting urinary monocyte chemotactic peptide-1 in renal transplant recipient].
abstract: OBJECTIVE
  To detect the content of monocyte chemotactic peptide-1(MCP-1) and to investigate the role of MCP-1 in acute renal graft rejection.
  
  
  METHODS
  Urinary MCP-1 level was detected by avidin biotin complex(ABC)ELISA.
  
  
  RESULTS
  Urinary MCP-1 levels in renal function stable renal transplantation of recipients and control group were (416+/-21) microg/L and (408+/-11) microg/L, respectively. Urinary MCP-1 level in renal transplantation recipients with acute rejection was (1195+/-58) microg/L, which was notably higher than that in control group and renal function stable recipients (P<0.01). After anti-rejection treatment, urinary MCP-1 level decreased markedly in patients who responded to treatment.
  
  
  CONCLUSIONS
  The urinary MCP-1 level is correlated closely with acute renal graft rejection and its increase may indicate ongoing acute renal rejection. Detection of urinary MCP-1 level may contribute to early diagnosis and prognostic judgement of acute graft rejection.
authors.affiliation: Department of Urology, Fuzhou General Hospital of Nanjing Military Area, Fuzhou 350025, China.
authors.forename: Xing-hui
authors.initials: XH
authors.lastname: Sun
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Tan
authors.forename: Wei-zhen
authors.initials: WZ
authors.lastname: Wu
authors.forename: Wen-hong
authors.initials: WH
authors.lastname: Lin
authors.forename: Qian-sheng
authors.initials: QS
authors.lastname: Li
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Fang
mesh_terms: D000208:Acute Disease; D000328:Adult; D018932:Chemokine CCL2 / Q000502:physiology / Q000652:urine*; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D018932:Chemokine CCL2