title: Effect of viewing a humorous vs. nonhumorous film on bronchial responsiveness in patients with bronchial asthma.
abstract: The effect of viewing a humorous film on bronchial responsiveness to methacholine [methacholine study: 20 healthy participants and 20 patients with house dust mite (HDM)-allergic bronchial asthma (BA)] or to epigallocatechin gallate (EGCg; EGCg study: 15 normal participants and 15 EGCg-allergic BA patients) was studied. At baseline, bronchial challenge test to methacholine (20 normal participants and 20 HDM-allergic BA patients) or EGCg (15 normal participants and 15 EGCg-allergic BA patients) were performed. After 2 weeks, patients and healthy participants were randomly assigned to watch a humorous or a nonhumorous film. Two weeks later, the alternate film was watched. Immediately after viewing, bronchial challenge test to methacholine or ECGg to each study group were performed. Viewing a humorous film significantly reduced bronchial responsiveness to methacholine or EGCg, while viewing a nonhumorous film failed to do so in BA patients without affecting bronchial responsiveness to methacholine or EGCg in healthy participants. These findings indicate that viewing a humorous film may be useful in the treatment and study of BA.
authors.affiliation: Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Uji-City, Kyoto 611-0021, Japan. h-kimata@takedahp.or.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Kimata
mesh_terms: D000328:Adult; D000339:Affect; D000485:Allergens; D001249:Asthma / Q000503:physiopathology* / Q000523:psychology* / Q000628:therapy; D016535:Bronchial Hyperreactivity / Q000139:chemically induced / Q000523:psychology* / Q000628:therapy; D001985:Bronchial Provocation Tests / Q000379:methods; D016085:Bronchoconstrictor Agents; D002392:Catechin / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D027641:Laughter Therapy / Q000523:psychology*; D008297:Male; D016210:Methacholine Chloride; D012016:Reference Values; D012129:Respiratory Function Tests / Q000523:psychology; D014925:Wit and Humor as Topic / Q000523:psychology*
chemical_list: D000485:Allergens; D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D002392:Catechin; C057580:gallocatechol