title: Synthesis, characterization and cytotoxicity evaluation of some new platinum(II) complexes of tetrazolo[1,5-a]quinolines.
abstract: Several new platinum(II) complexes of the general formulae cis-[PtCl(2)(DMSO)L], where L is a Schiff base or hydrazone derived from tetrazolo[1,5-a]quinoline-4-carboxaldehyde as carrier ligands, have been synthesized and characterized physicochemically and spectroscopically. These platinum complexes which are structurally analogues to what so called cisplatin [cis-[PtCl2(NH3)2]; the first generation anticancer agent] were evaluated for their cytotoxicity on HL-60 (human promyelocytic leukemia) cells. Two of the platinum complexes were almost similar in their activity to cisplatin, while the remaining three complexes have demonstrated higher efficacy than that of cisplatin. Based on our findings, these novel platinum complexes appear to be valuable leading compounds with high efficacy.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Bekhit
authors.forename: Ola A
authors.initials: OA
authors.lastname: El-Sayed
authors.forename: Talal A K
authors.initials: TA
authors.lastname: Al-Allaf
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
authors.forename: Muhammed
authors.initials: M
authors.lastname: Kunhi
authors.forename: Subramanian Manogaran
authors.initials: SM
authors.lastname: Pulicat
authors.forename: Khalid
authors.initials: K
authors.lastname: Al-Hussain
authors.forename: Fahad
authors.initials: F
authors.lastname: Al-Khodairy
authors.forename: Jamal
authors.initials: J
authors.lastname: Arif
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry / Q000633:toxicity; D005069:Evaluation Studies as Topic; D006801:Humans; D008024:Ligands; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010984:Platinum / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D009944:Organoplatinum Compounds; D011804:Quinolines; D010984:Platinum; D002945:Cisplatin