Expression of trefoil peptides in the subtypes of intestinal metaplasia.
We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.
Kim
Byung-Wook
BW
Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea. bleok@olmh.cuk.ac.kr
Kim
Kyoung-Mee
KM
Lee
Bo-In
BI
Maeng
Lee-So
LS
Choi
Hwang
H
Cho
Se-Hyun
SH
Chae
Hiun-Suk
HS
Kim
Jae-Kwang
JK
Choi
Kyu-Yong
KY
Chung
In-Sik
IS
D014408:Biomarkers, Tumor / Q000378:metabolism*; D004415:Dyspepsia / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009077:Mucins / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D010455:Peptides / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins
D014408:Biomarkers, Tumor; D009077:Mucins; D009124:Muscle Proteins; D010455:Peptides; D011506:Proteins; C051838:TFF1 protein, human; C000604007:TFF2 protein, human; C082495:TFF3 protein, human; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins