title: Synthesis and biological evaluation of novel apio nucleosides with thiazole-4-carboxamide and 1,2,4-triazole-3-carboxamide.
abstract: In view of biological activities of azole nucleosides and apio-dideoxynucleoside, novel apio nucleoside analogues (1 and 2) with thiazole and triazole base moiety were synthesized using 2,3-O-isopropylidene-apio-beta-D-furanose (3), which was prepared from D-mannose.
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: Myong Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
authors.forename: Joong Hyup
authors.initials: JH
authors.lastname: Kim
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Shin
authors.forename: Soon Yong
authors.initials: SY
authors.lastname: Chung
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
mesh_terms: D008358:Mannose / Q000031:analogs & derivatives* / Q000737:chemistry; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009705:Nucleosides; D013844:Thiazoles; D014230:Triazoles; D008358:Mannose