Effects of risperidone on destructive behavior of persons with developmental disabilities: III. Functional analysis.
Functional analyses were conducted during a double-blind, placebo-controlled study of the atypical antipsychotic medication risperidone with 13 individuals. Risperidone was effective in reducing destructive behavior (compared to placebo) for 10 participants. For 7 of these responders, an undifferentiated pattern of responding occurred across their baseline functional analysis conditions (i.e., a similar rate of responding across conditions), and risperidone treatment produced nonspecific reductions of their destructive behavior across functional analysis conditions. For the remaining 3 responders, a differentiated pattern of responding occurred across their baseline functional analysis conditions (i.e., an elevated rate of responding occurred in a specific condition), and risperidone treatment produced function-specific reductions of their destructive behavior.
Zarcone
Jennifer R
JR
Department of Psychiatry, University of Kansas, University of Kansas Medical Center, Kansas City 66160-7341, USA. JZarcone2@kumc.edu
Lindauer
Steven E
SE
Morse
Paige S
PS
Crosland
Kimberly A
KA
Valdovinos
Maria G
MG
McKerchar
Todd L
TL
Matthew Reese
R
R
Hellings
Jessica A
JA
Schroeder
Stephen R
SR
D000328:Adult; D000374:Aggression / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002648:Child; D002658:Developmental Disabilities / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D018967:Risperidone / Q000627:therapeutic use*; D016728:Self-Injurious Behavior / Q000150:complications / Q000517:prevention & control*
D014150:Antipsychotic Agents; D018967:Risperidone