title: Sonographic prognostic factors in prenatal diagnosis of SCT.
abstract: OBJECTIVE
  A subset of fetuses with sacrococcygeal teratomas (SCT) develops hydrops caused by high-output heart failure. Identification of fetuses at risk for hydrops is important because surgical intervention may reverse the pathophysiology of the disease. The aim of this study was to evaluate sonographic prognostic factors regarding tumor morphology and vascularity associated with the development of hydrops in utero.
  
  
  METHODS
  Over a 10-year period, we identified 7 fetuses with SCT diagnosed antenatally and managed at the University of Mainz. We retrospectively reviewed the charts of mothers and infants and recorded data on prenatal diagnosis, tumor size and localization, perinatal management, neonatal care, and fetal outcome.
  
  
  RESULTS
  The diagnosis of SCT was made in all cases by ultrasound. The median gestational age at the time of initial diagnosis was 23 weeks. In 3 cases, signs of fetal heart failure were detected by ultrasound. Pathological blood flow in the venous system was further noted in 2 cases. One fetus developed hydrops. The mean gestational age at delivery was 35 weeks, depending on the presence or absence of maternal or fetal complications. Six infants were delivered by cesarean section, and 1 by vaginal delivery. After fetal stabilization, surgery was performed in 5 of 7 cases. Inadequate ventilation secondary to prematurity was a contributing factor to death in 1 fetus. One fetal intrauterine death occurred at 27 weeks of gestation.
  
  
  CONCLUSIONS
  Pregnancies with antenatally diagnosed fetal SCT necessitate frequent monitoring to ensure the detection of fetal/maternal complications by ultrasound and Doppler ultrasound. The most important prognostic criteria were cardiomegaly, fetal hydrops, and increased preload indexes of the fetal venous system as sign of fetal heart failure. Many studies show that the occurrence of pulsations in the umbilical vein of a hydropic fetus correlates with a poor fetal outcome. The decision on the optimal time of delivery should therefore be made by a multidisciplinary team of specialists.
authors.affiliation: Department of Obstetrics and Gynecology, and Ultrasound, Johannes Gutenberg University, Mainz, Germany. Neubert.Susanne@gmx.de
authors.forename: S
authors.initials: S
authors.lastname: Neubert
authors.forename: K
authors.initials: K
authors.lastname: Trautmann
authors.forename: B
authors.initials: B
authors.lastname: Tanner
authors.forename: E
authors.initials: E
authors.lastname: Steiner
authors.forename: F
authors.initials: F
authors.lastname: Linke
authors.forename: F
authors.initials: F
authors.lastname: Bahlmann
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D012445:Sacrococcygeal Region / Q000000981:diagnostic imaging / Q000601:surgery; D013724:Teratoma / Q000000981:diagnostic imaging* / Q000601:surgery; D016216:Ultrasonography, Prenatal / Q000379:methods / Q000706:statistics & numerical data*