[Study on the resistance of methicillin-resistant staphylococcus aureus to iodophor and chlorhexidine].
OBJECTIVE
To study the resistance of methicillin-resistant staphylococcus aureus (MRSA), an indicator used in hospitals.


METHODS
We used minimal inhibitory concentrations (MIC) of iodoph and chlorhexidine to MRSA, methicillin-sensitive staphylococcus aureus (MSSA) and staphylococcus aureus ATCC6538.


RESULTS
Obvious difference between MRSA and MSSA the MIC of Iodophor was noticed. Among MICs, 5.3% MRSA strains were 2-folds and 28.9% MRSA strains were 1.5 fold more than staph. aureus ATCC6538, while the MIC of 11.1% MSSA strains raised 1.5 fold than ATCC6538. The MIC of 83.3% MSSA strains were the same to staph. aureus ATCC6538. The MIC of chlorhexidine to MRSA, MSSA and staphylococcus aureus ATTC6538 were similar to each other.


CONCLUSIONS
Results showed that some MRSA were more resistant to Iodophor than staph. aureus ATCC6538, but remained the same resistance to Chlorhexidine. Thus the concentration of Iodophor should be raised when the resistant strains were isolated.
Zhang
Yan-hong
YH
The First Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China.
Liu
Xiu-yan
XY
Zhu
Li-Li
LL
Yu
You-zhi
YZ
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002710:Chlorhexidine / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007466:Iodophors / Q000494:pharmacology; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*
D000890:Anti-Infective Agents; D007466:Iodophors; D008712:Methicillin; D002710:Chlorhexidine