title: [Hepatitis C virus infection and clinical outcome of kidney transplantation].
abstract: OBJECTIVE
  To study the influence of hepatitis C virus (HCV) infection on the clinical outcome of kidney transplantation.
  
  
  METHODS
  The recipient/graft survival, the incidence of acute/chronic rejection and cause of death in 86 HCV-infected recipients of renal transplantation were compared with those in another 86 recipients without HCV infection.
  
  
  RESULTS
  HCV-infected recipients had significantly shorter 5-year survival (74.4%) than those without HCV infection (87.2%, P<0.01). The 1-year (94.2%/90.7% vs 96.8%/96.0%) and 3-year recipient/graft survival rates (88.4%/79.1% vs 90.7%/87.2%), the incidence of acute/chronic rejection (31.3% vs 21.2%, and 12.5% vs 6.5%) and the 5-year graft survival (73.3%/81.4%) were comparable between the two groups (P>0.05). Hepatic disease was identified as the primary cause of mortality.
  
  
  CONCLUSIONS
  HCV infection may affect the long-term survival of the recipients with kidney transplantation, and therefore should be considered as a relative contraindication of kidney transplantation.
authors.affiliation: Department of Kidney Transplantation, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. liuxy@fimmu.com
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Yu
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Wang
authors.forename: Shao-jie
authors.initials: SJ
authors.lastname: Fu
authors.forename: Yi-bin
authors.initials: YB
authors.lastname: Wang
authors.forename: Chu-fu
authors.initials: CF
authors.lastname: Du
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.forename: Wen-feng
authors.initials: WF
authors.lastname: Deng
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006085:Graft Survival; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D007166:Immunosuppressive Agents