title: Congenital neutropenia.
abstract: The term "congenital neutropenia" signifies neutropenia that is present at birth. It includes a wide variety of disorders, some transient and others life long. Some varieties of congenital neutropenia are mild, with blood neutrophil concentrations below normal but not low enough to constitute a significant host defense deficiency. Other varieties of congenital neutropenia are characterized by low blood neutrophil concentrations and a predisposition to repeated infections.
authors.affiliation: Department of Pediatrics, University of South Florida College of Medicine, 801 6th Avenue South, Box 9360, St. Petersburg, FL 33701, USA. rchriste@peds.ufl.edu
authors.forename: Robert D
authors.initials: RD
authors.lastname: Christensen
authors.forename: Darlene A
authors.initials: DA
authors.lastname: Calhoun
mesh_terms: D000143:Acids / Q000652:urine; D000217:Acyltransferases; D023181:Antimicrobial Cationic Peptides / Q000172:deficiency; D002311:Cardiomyopathy, Dilated / Q000235:genetics; D054804:Cathelicidins; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D005953:Glycogen Storage Disease Type I / Q000150:complications; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use; D049673:History, 20th Century; D006801:Humans; D007154:Immune System Diseases / Q000150:complications; D007231:Infant, Newborn; D019272:Leukocyte Elastase / Q000235:genetics; D008661:Metabolism, Inborn Errors / Q000150:complications; D009154:Mutation; D009503:Neutropenia / Q000151:congenital* / Q000209:etiology / Q000266:history / Q000503:physiopathology; D011506:Proteins / Q000235:genetics; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D013548:Sweden; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics
chemical_list: D000143:Acids; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D011506:Proteins; D011994:Recombinant Proteins; D014157:Transcription Factors; D016179:Granulocyte Colony-Stimulating Factor; D000217:Acyltransferases; C486363:tafazzin protein, mouse; C108675:TAFAZZIN protein, human; D019272:Leukocyte Elastase