Preliminary immunomodulatory activities of methanol extracts of Eclipta alba and Centella asiatica.
An attempt has been made to assess the immunomodulatory activity of methanol extracts of whole plant of E. alba (1.6% wedelolactone) and C. asiatica (0.18% of asiaticoside) at five dose levels (dose-response relationship) ranging from 100 to 500 mg/kg body wt. using carbon clearance, antibody titer and cyclophosphamide immunosuppression parameters. In the case of E. alba, the phagocytic index and antibody titer increased significantly and the F ratios of the phagocytic index and WBC count were also significant. Regression analysis showed linearity in patterns of the dose-response relationship, greatest in the case of the phagocytic index, moderate in the WBC count and lowest in the antibody titer. For C. asiatica, significant increases in the phagocytic index and total WBC count were observed and the F ratio of the phagocytic index was also significant. Regressed values revealed maximum linearity in the case of the phagocytic index, moderate linearity in the total WBC count and lowest linearity in the antibody response.
Jayathirtha
M G
MG
Pharmacy Department, The M.S. University of Baroda, Kalabhavan, Vadodara 390 001, India.
Mishra
S H
SH
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D028041:Centella; D004305:Dose-Response Relationship, Drug; D036601:Eclipta; D005260:Female; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D010936:Plant Extracts