title: [Intrathecal baclofen in severe spasticity due to multiple sclerosis].
abstract: Intrathecal administration of baclofen via programmable pump is a highly effective treatment method in severe spasticity resistant to oral medications. The authors describe a case of severe spasticity with tetraplegia and painful (> 10 a day) muscle spasms in the upper and lower limbs and paraspinal muscles, in a patient with clinically definite diagnosis of multiple sclerosis (MS). The 34-year-old female patient with a 15-year history of MS, suffering from lower limb spasticity with pes equinovarus since 1995, was treated with very good results with botulinum toxin injections of calf muscles (14 sessions of Dysport 1500iu till 2002). In the early 2002 she developed tetraplegia with severe, generalized and intractable spasticity. After 4 months of ineffective polytherapy (with high doses of oral baclofen, tizanidine, gabapentine, clonidine, diazepam) and the patient's enormous sufferings (she could neither sit up nor voluntarily change her position in bed), a programmable baclofen pump (Medtronic) was implanted. As soon as a few days after the surgery she could stand, sit and move voluntarily, her painful spasms disappeared, and her bladder catheter was removed. At a 6-month follow-up the effect was stable--she was able to walk a long distance outdoors with the aid of a crutch. The daily dose of the drug is 500 micrograms. No side effects of complications were noted.
authors.affiliation: Kliniki Neurochirurgii Akademii Medycznej w Gdańsku. jarslawek@poczta.onet.pl
authors.forename: Jarosław
authors.initials: J
authors.lastname: Sławek
authors.forename: Piotr
authors.initials: P
authors.lastname: Zieliński
authors.forename: Wiesława
authors.initials: W
authors.lastname: Hołub-Kucharska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kaniszewska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Paczkowska
authors.forename: Paweł
authors.initials: P
authors.lastname: Słoniewski
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal / Q000379:methods; D009103:Multiple Sclerosis / Q000503:physiopathology*; D009125:Muscle Relaxants, Central / Q000008:administration & dosage*; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D011782:Quadriplegia / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen