title: The polyglutamine tract of androgen receptor: from functions to dysfunctions in motor neurons.
abstract: This review summarizes the mechanisms of neurotoxicity associated to androgen receptor containing an elongated polyglutamine tract responsible for motor neuronal cell death.
authors.affiliation: Institute of Endocrinology, Centre of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy. Angelo.Poletti@unimi.it
authors.forename: Angelo
authors.initials: A
authors.lastname: Poletti
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000166:cytology / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000737:chemistry / Q000378:metabolism*; D020966:Muscular Disorders, Atrophic / Q000378:metabolism*; D009154:Mutation; D009498:Neurotoxins / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
chemical_list: D009498:Neurotoxins; D010455:Peptides; D011944:Receptors, Androgen; C097188:polyglutamine