Antinociceptive profile of 2-phenylselenenyl-1,8-cineole in mice.
2-Phenylselenenyl-1,8-cineole (PSC) increased both the pentobarbital-induced sleeping time and the reaction time (up to 2 h) in the tail immersion method. PSC also caused dose-dependent inhibition of acetic acid induced writhing with maximum inhibition of 93.4% and was approximately 8.5-fold more potent than 1,8-cineole. These findings show that PSC presents sedative effect and significant antinociceptive activity.
de Sousa
Damião Pergentino
DP
Laboratório de Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Sao Carlos, Sao Paulo State, Brazil.
Raphael
Ellen
E
Brocksom
Ursula
U
Brocksom
Timothy John
TJ
D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry* / Q000494:pharmacology*; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D018036:Selenium Compounds / Q000737:chemistry* / Q000494:pharmacology*
C495411:2-phenylselenenyl-1,8-cineole; D000700:Analgesics; D039821:Monoterpenes; D016566:Organoselenium Compounds; D018036:Selenium Compounds