title: Peters' anomaly with bilateral perisylvian polymicrogyria and abdominal calcification.
abstract: We report a neonatal case of Peters' anomaly with bilateral perisylvian polymicrogyria and abdominal calcification. The male infant was born after a normal labor. Bilateral central corneal opacities with iridocorneal strands indicated Peters' anomaly. The X-ray and abdominal computed tomography demonstrated multiple calcifications beneath the diaphragma around the liver and the spleen. TORCH serology was negative. Intracranial calcification was not detected. Brain magnetic resonance imaging demonstrated bilateral perisylvian polymicrogyria. Abdominal calcification was suspected to be related to vascular disruption. Bilateral perisylvian polymicrogyria has been thought to result from ischemic events such as intrauterine hypotension or vascular occlusions. Based on these considerations, we conclude that a vascular disruption sequence may an important pathogenetic mechanism of Peters' anomaly.
authors.affiliation: Department of Pediatrics, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Japan.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Morimoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Takano
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sakaue
authors.forename: Chihiro
authors.initials: C
authors.lastname: Sawai
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Aotani
authors.forename: Shigeki
authors.initials: S
authors.lastname: Koshida
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeuchi
mesh_terms: D000005:Abdomen; D000015:Abnormalities, Multiple; D001921:Brain / Q000002:abnormalities*; D002114:Calcinosis / Q000151:congenital*; D003318:Corneal Opacity / Q000151:congenital*; D006801:Humans; D007231:Infant, Newborn; D007499:Iris Diseases / Q000151:congenital*; D008297:Male