Solid organ transplantation in HIV-infected recipients.
HIV is generally regarded as an acceptable reason to exclude a potential recipient from consideration for transplantation. Most of the data in the literature regarding transplantation of HIV sero-positive individuals pertains to the time prior to the administration of Highly Active Anti-Retroviral Therapy (pre-HAART). This data, therefore, provides little guidance for the management of HIV-positive individuals in the current era. The development of HAART has resulted in a decreased mortality. With prolonged survival more HIV-infected individual are developing end stage organ disease from co-existing conditions such as HCV and HBV, and diseases common in the general population such as diabetes mellitus and hypertension. This has lead to clinicians, researchers and patients to actively investigate the role of solid organ transplantation in HIV-infected individuals. In this article We review the literature to date in liver and renal transplantation, including more recent data in patients receiving HAART.
El Sayegh
Suzanne
S
Division of Nephrology, Mount Sinai School of Medicine, New York 10029, USA.
Keller
Marla J
MJ
Huprikar
Shirish
S
Murphy
Barbara
B
D016263:AIDS-Associated Nephropathy / Q000601:surgery; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D017758:Infectious Disease Transmission, Patient-to-Professional; D016030:Kidney Transplantation; D017093:Liver Failure / Q000150:complications / Q000601:surgery; D016031:Liver Transplantation; D016377:Organ Transplantation / Q000941:ethics; D051437:Renal Insufficiency / Q000150:complications / Q000601:surgery
D007166:Immunosuppressive Agents