Synthesis and anti-inflammatory effects of novel pimarane diterpenoid analogs.
Syntheses and excellent anti-inflammatory effects of a series of novel acanthoic acid analogs are reported. In particular, the mechanistic basis for their anti-inflammatory effects is also described.
Suh
Young-Ger
YG
College of Pharmacy, Pharmaceutical Chemistry, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, South Korea. ygsuh@snu.ac.kr
Lee
Kwang-Ok
KO
Moon
Sung-Hyun
SH
Seo
Seung-Yong
SY
Lee
Yong-Sil
YS
Kim
Seok-Ho
SH
Paek
Seung-Mann
SM
Kim
Young-Ho
YH
Lee
Yun-Sang
YS
Jeong
Jae Min
JM
Lee
Seung Jin
SJ
Kim
Sang Geon
SG
D045784:Abietanes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D016861:Cyclooxygenase Inhibitors / Q000378:metabolism; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000378:metabolism; D008956:Models, Chemical; D009569:Nitric Oxide / Q000037:antagonists & inhibitors
D045784:Abietanes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; C099958:acanthoic acid; C433018:pimarane; D009569:Nitric Oxide