Near-triploid acute lymphoblastic leukemia with TEL/AML1 translocation.
An 11-year-old girl was diagnosed as B-precursor acute lymphoblastic leukemia (ALL) with co-expression of myeloid antigens. Cytogenetic analysis revealed a near-triploid (75-82 chromosomes/cell) abnormal chromosomal complement. Fluroscent in situ hybridization studies indicated presence of TEL/AMLI fusion genes. We discuss the prognostic relevance of TEL/AML1 in this rare near-triploid subtype of ALL.
Bakhshi
Sameer
S
Division of Pediatric Hematology Oncology, Department of Pediatrics, Children's Hospital of Michigan, Wayne State University and School of Medicine, Detroit, MI 48201, USA. sambakh@hotmail.com
Chitlur
Meera
M
Cushing
Barbara
B
D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D050676:Core Binding Factor Alpha 2 Subunit; D005260:Female; D006801:Humans; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011123:Polyploidy; D011379:Prognosis; D014178:Translocation, Genetic; D000097764:ETS Translocation Variant 6 Protein
D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein