[Antiischemic efficacy of perfluoroorganic compounds in patients with renal inflammation].
To improve metabolism and reduce activity of pyoinflammatory reactions in complicated infection of the kidneys, we studied pharmacological potentialities of perfluorocarbon emulsion perfluoran. Correlation between oxygen unbalance, development of cell membrane pathology and activity of pyoinflammatory affection of the kidneys was studied in 67 patients with acute obstructive pyelonephritis complicated by urosepsis. It was found that surgical manipulations aiming at recovery of urodynamics and normalization of hemodynamic indices of the kidney are accompanied by development of reperfusion syndrome of the affected and contralateral kidney. Use of perfluoran in this situation promotes rapid compensation of gas transport disturbances, stabilization of the equilibrium in the system prooxidants-antioxidants, regress of pyoinflammatory reactions, earlier recovery of functions of a more affected kidney and antiischemic protection of the contralateral organ. Antiischemic and membrane-stabilizing actions of perfluoran make this drug adequate for use in patients with complicated renal infection.
Ushakova
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D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002462:Cell Membrane / Q000473:pathology; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D007668:Kidney / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011704:Pyelonephritis / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D015427:Reperfusion Injury / Q000188:drug therapy; D018805:Sepsis / Q000209:etiology / Q000628:therapy; D014563:Urodynamics / Q000187:drug effects*
D000975:Antioxidants; D005466:Fluorocarbons