title: Combating bioterrorism with personal computers.
abstract: Using personal computers in a grid is permitting the in silico screening of millions of molecules to seek out potential inhibitors of agents that pose bioterror threats. Current projects are targeting anthrax and smallpox, but the approach has many attractions for investigating any known protein target and its inhibition.
authors.affiliation: Central Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QH, UK. graham.richards@chemistry.ox.ac.uk
authors.forename: W Graham
authors.initials: WG
authors.lastname: Richards
authors.forename: Guy H
authors.initials: GH
authors.lastname: Grant
authors.forename: Karl N
authors.initials: KN
authors.lastname: Harrison
mesh_terms: D000595:Amino Acid Sequence; D000881:Anthrax / Q000517:prevention & control; D023482:Bioterrorism / Q000517:prevention & control*; D019295:Computational Biology / Q000379:methods*; D004264:DNA Topoisomerases, Type I / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D008838:Microcomputers; D008962:Models, Theoretical; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D012899:Smallpox / Q000517:prevention & control
chemical_list: D004264:DNA Topoisomerases, Type I