Squash smear findings of spherical amyloid in pituitary prolactinoma. A case report.
BACKGROUND
Pituitary prolactinoma containing spherical amyloid is rare. Squash smear findings of spherical amyloid in pituitary prolactinoma are characteristic.


METHODS
A 25-year-old woman presented with a pituitary tumor. The intraoperative squash smear showed abundant, homogeneous, eosinophilic material with multiple prominent striations. The scattered atypical cells in the periphery contained an irregular, bizarre nucleus; coarse chromatin; occasional prominent nucleoli; rare cytoplasm; and prolactin immunoreactivity.


CONCLUSIONS
The characteristic squash smear findings should be helpful in the diagnosis of this rare tumor.
Kim
Se Hoon
SH
Department of Pathology, College of Medicine, Yonsei University, Seoul, South Korea.
Kim
Sun Ho
SH
Lee
Seung-Koo
SK
Kim
Tai Seung
TS
D000328:Adult; D000682:Amyloid / Q000032:analysis*; D001718:Birefringence; D003224:Congo Red / Q000378:metabolism; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008279:Magnetic Resonance Imaging; D008859:Microscopy, Polarization; D010503:Periodic Acid-Schiff Reaction; D010911:Pituitary Neoplasms / Q000737:chemistry* / Q000000981:diagnostic imaging / Q000473:pathology*; D015175:Prolactinoma / Q000737:chemistry* / Q000473:pathology*; D011859:Radiography; D013048:Specimen Handling
D000682:Amyloid; D003224:Congo Red