The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.
3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.
Hale
Jeffrey J
JJ
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. jeffrey_hale@merck.com
Doherty
George
G
Toth
Leslie
L
Li
Zhen
Z
Mills
Sander G
SG
Hajdu
Richard
R
Ann Keohane
Carol
C
Rosenbach
Mark
M
Milligan
James
J
Shei
Gan-Ju
GJ
Chrebet
Gary
G
Bergstrom
James
J
Card
Deborah
D
Rosen
Hugh
H
Mandala
Suzanne
S
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D063065:Organophosphonates / Q000138:chemical synthesis; D009943:Organophosphorus Compounds / Q000138:chemical synthesis; D010761:Phosphorus Radioisotopes; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*; D049349:Receptors, Lysosphingolipid / Q000819:agonists*; D013329:Structure-Activity Relationship
D008024:Ligands; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010761:Phosphorus Radioisotopes; D043562:Receptors, G-Protein-Coupled; D049349:Receptors, Lysosphingolipid