Anti-platelet pentacyclic triterpenoids from leaves of Campsis grandiflora.
Five pentacyclic triterpenoids, oleanolic acid (1), hederagenin (2), ursolic acid (3), tormentic acid (4) and myrianthic acid (5), were isolated from the methanol extract of the leaves of Campsis grandiflora, and structures of the compounds were established by the spectroscopic methods. Compounds 2, 3, 4, and 5 were isolated for the first time from the genus Campsis. All of the compounds (IC50: 45.3, 32.8, 82.6, 42.9 and 46.2 microM respectively) were as equivalently inhibitive as acetylsalicylic acid (IC50: 57.0 microM) on epinephrine induced platelet aggregation.
Jin
Jing Ling
JL
Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
Lee
Yong Yook
YY
Heo
Jung Eun
JE
Lee
Sanghyun
S
Kim
Jeong Mi
JM
Yun-Choi
Hye Sook
HS
D000818:Animals; D029402:Bignoniaceae; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D014315:Triterpenes