title: Gender-dependent differences in biological rhythms of mice.
abstract: The advantage of a variable's rhythm resides in its optimal time-phasing. This implies that, for a given function, members of a species will strive to exhibit identical time-phasing namely, their inter-individual genetic differences will be masked. To examine the generality of this assumption we explored if inbred mice exhibit gender dependent differences in rhythm parameters of biochemical variables. Male and female mice, entrained by exposure to 12:12 light:dark illumination were sacrificed, every 3 hours over a 27 hours period. Activities of creatine-phosphokinase (CK) and alkaline- phosphatase (AP), white blood cell (WBC) counts and urea nitrogen (UN) concentration were determined at each time point. For each significant rhythm four parameters were computed: period, acrophase, mesor and amplitude. In addition two derived parameters were also calculated: relative-amplitude (RA) and the rate of change in RA (CRA) which provide information about the slope and width of the peak. Patterns of most variables exhibited a compound rhythm containing two significant periodicities. Gender dependent differences were documented in the parameters of most rhythms indicating that the genetic and physiological differences limit to a certain extent the phasing ability of the entraining signals and point to an independent control of each of the rhythm parameters.
authors.affiliation: Department of Hunam Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Weigl
authors.forename: L
authors.initials: L
authors.lastname: Peleg
authors.forename: A
authors.initials: A
authors.lastname: Dotan
authors.forename: I E
authors.initials: IE
authors.lastname: Ashkenazi
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D002940:Circadian Rhythm / Q000502:physiology*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology; D008029:Lighting; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D012727:Sex Characteristics
chemical_list: D003402:Creatine Kinase; D000469:Alkaline Phosphatase