title: Elevated adrenomedullin mRNA in lymphoblastoid cells from schizophrenic patients.
abstract: Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of mental diseases. Using real-time quantitative PCR, we compared the ADM mRNA levels in lymphoblastoid cell lines between schizophrenic patients and controls. Male but not female schizophrenia patients had 2- to 3-fold higher ADM mRNA levels than controls (p<0.01). Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study.
authors.affiliation: Department of Psychiatry, Tzu-Chi General Hospital and Institute of Human Genetics, Tzu-Chi University, Hualien City, 970 Taiwan.
authors.forename: Chia-Hsing
authors.initials: CH
authors.lastname: Huang
authors.forename: Mao-Liang
authors.initials: ML
authors.lastname: Chen
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Tsai
authors.forename: Ming-Ta
authors.initials: MT
authors.lastname: Tsai
authors.forename: Chia-Hsiang
authors.initials: CH
authors.lastname: Chen
mesh_terms: D053607:Adrenomedullin; D000328:Adult; D002461:Cell Line, Transformed; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology*; D008297:Male; D010455:Peptides / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000503:physiopathology*; D012727:Sex Characteristics
chemical_list: D010455:Peptides; D012333:RNA, Messenger; D053607:Adrenomedullin