[Remote effects of Aroclor 1254 on the rat liver microsomal monooxygenase activity in acute pancreatitis].
Constitutive activities of the liver cytochromes P450 1A1, 1A2, 2C6 and 2B1 were lower in rats with the acute experimental pancreatitis during ten days of this disease. In rats pretreated with a single dose of Arochlor 1254 on the second day of pancreatitis activities of these enzymes remained elevated to the tenth day. Thus, acute pancreatitis caused long-term suppression of microsomal monooxygenase system, whereas induction by Arochlor 1254 increased cytochromes P450 activity in both control animals and in rats with pancreatitis.
Prokop'eva
N V
NV
Institute of Molecular Biology and Biophysics, Siberian Branch, Russian Academy of Medical Science, ul. Timakova 2, Novosibirsk, 630117 Russia.
Guliaeva
L F
LF
Poliakova
N E
NE
D000208:Acute Disease; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D020111:Chlorodiphenyl (54% Chlorine) / Q000494:pharmacology*; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D010195:Pancreatitis / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar
D020111:Chlorodiphenyl (54% Chlorine); D001189:Aryl Hydrocarbon Hydroxylases