[Ultrastructural characteristics of rat adrenal cortex cultured cells in the norm and after calcium ionophore A23187 and adrenocorticotropic hormone application].
The ultrastructure of a fasciculata-reticularis zone cells of a rat adrenal cortex in norm, and after application of adrenocorticotropic hormone (ACTH) and calcium ionophore A23187 was investigated. In the control it has been revealed three types of cells which differed on the ultrastructure. ACTH or ionophore A23187 application resulted in disappearance of a difference in ultrastructure of cells of different types, also all cells got morphological attributes of accelerated steroidogenesis. The probable role of cells with different types of ultrastructure for fasciculata-reticularis zone function, and also prospective participation of calcium ions in ACTH influences on ultrastructure of a fasciculata-reticularis zone is discussed.
Tokar
S L
SL
Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Koval'
L M
LM
Luk'ianets'
O O
OO
Iavors'ka
O M
OM
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D002478:Cells, Cultured; D007476:Ionophores / Q000494:pharmacology*; D051381:Rats
D000305:Adrenal Cortex Hormones; D007476:Ionophores; D000001:Calcimycin; D000324:Adrenocorticotropic Hormone; D002122:Calcium Chloride