Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives.
A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin.
Sung Kim
Jin
J
College of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea.
Lee
Hyun-Jung
HJ
Suh
Myung-Eun
ME
Choo
Hea-Young Park
HY
Lee
Sang Kook
SK
Park
Hyen Joo
HJ
Kim
Choonmi
C
Park
Sang Woo
SW
Lee
Chong-Ock
CO
D045744:Cell Line, Tumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010793:Phthalazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D012235:Rhodamines / Q000494:pharmacology
D007093:Imidazoles; D010793:Phthalazines; D012235:Rhodamines; C022027:lissamine rhodamine B; C043388:phthalazine