title: The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.
abstract: The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bamford
authors.forename: E
authors.initials: E
authors.lastname: Dawson
authors.forename: S
authors.initials: S
authors.lastname: Forbes
authors.forename: J
authors.initials: J
authors.lastname: Clements
authors.forename: R
authors.initials: R
authors.lastname: Pettett
authors.forename: A
authors.initials: A
authors.lastname: Dogan
authors.forename: A
authors.initials: A
authors.lastname: Flanagan
authors.forename: J
authors.initials: J
authors.lastname: Teague
authors.forename: P A
authors.initials: PA
authors.lastname: Futreal
authors.forename: M R
authors.initials: MR
authors.lastname: Stratton
authors.forename: R
authors.initials: R
authors.lastname: Wooster
mesh_terms: D016208:Databases, Factual; D011905:Genes, ras; D006801:Humans; D020407:Internet; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf / Q000235:genetics; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins
chemical_list: C117307:KRAS protein, human; D011518:Proto-Oncogene Proteins; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D019908:Proto-Oncogene Proteins c-raf; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins