title: Meperidine-induced seizure after revision hip arthroplasty.
abstract: Musculoskeletal injuries secondary to seizures are well documented and have a variable incidence. Meperidine (Demerol [Abbott, Abbott Park, IL]) has been used for many years in the postoperative setting for pain control; however, in high doses, it has been associated with seizure. We report the case of patient who experienced a tonic-clonic seizure 5 days after hip revision surgery, resulting in dissociation of the socket from the acetabulum with an associated acetabular fracture. In this patient, meperidine administered for patient-controlled analgesia within recommended range caused the seizure.
authors.affiliation: David Geffen School of Medicine at the University of California Los Angeles, 90017, USA.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Beaulé
authors.forename: M Iain
authors.initials: MI
authors.lastname: Smith
authors.forename: Vinh N
authors.initials: VN
authors.lastname: Nguyen
mesh_terms: D000077:Acetabulum / Q000293:injuries*; D000328:Adult; D000700:Analgesics / Q000009:adverse effects*; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D006617:Hip Dislocation / Q000209:etiology; D006801:Humans; D008614:Meperidine / Q000009:adverse effects*; D010146:Pain / Q000188:drug therapy; D012086:Reoperation; D012640:Seizures / Q000139:chemically induced* / Q000150:complications
chemical_list: D000700:Analgesics; D008614:Meperidine