title: A case of plasmacytic hyperplasia arising in a kidney allograft salvaged with immunosuppression reduction alone.
abstract: Post-transplant lymphoproliferative disorder (PTLD) is a well-known complication of organ transplantation. Plasmacytic hyperplasia (PH) is thought of as the mildest form of PTLD; however, a graftectomy is necessary in most situations. We experienced an interesting case of PH arising in a kidney allograft, which could be relieved with a reduction in immunosuppression. A 27-year-old female underwent a living-related kidney transplantation. A 3-month non-episode protocol biopsy unexpectedly showed the devastating appearance of polymorphic plasma cell infiltration into the graft intersitium, compatible with PH. The PH was located in the graft by radiographic examinations. The infiltration of plasma cell disappeared completely on the 6-month graft biopsy specimen following immunosuppression reduction and the graft is functioning, although it was damaged by a subsequent acute rejection. Our present case indicates that some PTLD can be completely cured with a reduction in immunosuppression alone. The diagnostic modality for the evaluation of PTLD cell extinction is necessary to maintain graft function with adequate immunosuppression thereafter.
authors.affiliation: Department of Renal Transplantation, Sapporo City General Hospital, Sapporo, Japan. hiroshi.harada@doc.city.sapporo.jp
authors.forename: H
authors.initials: H
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: N
authors.initials: N
authors.lastname: Shimoda
authors.forename: T
authors.initials: T
authors.lastname: Seki
authors.forename: M
authors.initials: M
authors.lastname: Togashi
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: A
authors.initials: A
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Tahara
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Hirano
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007668:Kidney / Q000473:pathology*; D016030:Kidney Transplantation / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000628:therapy*; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents