Predictive value of SCC-Ag, CYFRA 21-1 and selected acute phase proteins in radiotherapy of pharyngeal and laryngeal cancer. A preliminary report.
The diagnostic sensitivity and specificity of tumor markers in head and neck cancers is not satisfactory. It is a stimulus for search of other biochemical indicators, among others determinations of acute phase proteins, helpful in head and neck cancers diagnostics and prognosis. In a group of 33 patients with squamous cell carcinoma of the pharynx and larynx (T1-4 N0-3 M0) CYFRA 21-1, SCC-Ag and acute phase proteins such as prealbumin, albumin, alpha-1 acid glycoprotein, alpha-1 antytrypsin, transferrin, ceruloplasmin and C-reactive protein (CRP) determinations were performed before radiotherapy. Significantly greater area under ROC curve for CYFRA 21-1 than for SCC-Ag was found. In T3-4 group, significantly lower albumin and higher AAG and CRP concentrations in comparison with T1-2 patients were observed. Multivariate analysis revealed that apart from tumor stage, elevated concentrations of SCC-Ag and/or CRP are independent unfavorable prognostic factors.
Kulpa
J
J
Department of Clinical Biochemistry, M. Skłodoska-Curie Memorial Institute, Cracow, Poland. z5jkulpa@cyf-kr.edu.pl
Stasik
Z
Z
Skołyszewski
J
J
Wójcik
E
E
Rychlik
U
U
Pudełek
K
K
D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000532:radiotherapy*; D015999:Multivariate Analysis; D010610:Pharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000532:radiotherapy*; D011379:Prognosis; D012372:ROC Curve; D012680:Sensitivity and Specificity; D015843:Serpins / Q000096:biosynthesis*; D013997:Time Factors; D016896:Treatment Outcome
D000209:Acute-Phase Proteins; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053539:Keratin-19; D015843:Serpins; C102012:antigen CYFRA21.1; C051072:squamous cell carcinoma-related antigen; D007633:Keratins