Reactions of TFDA with ketones. synthesis of difluoromethyl 2,2-difluorocyclopropyl ethers.
The sequential reaction of 2 equiv of difluorocarbene (generated from trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) by treatment with catalytic fluoride ion) with a series of electron-rich aromatic ketones and alpha,beta-unsaturated ketones leads to the formation of difluoromethyl 2,2-difluorocyclopropyl ethers in good yield.
Cai
Xiaohong
X
Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
Zhai
Yian
Y
Ghiviriga
Ion
I
Abboud
Khalil A
KA
Dolbier
William R
WR