title: LKB1 kinase: master and commander of metabolism and polarity.
abstract: LKB1, the product of a tumour suppressor gene, is a serine/threonine kinase that coordinates disparate cellular processes. Recent data have revealed novel functions for LKB1, providing new insight into the regulation of cell polarity and energy-generating metabolism.
authors.affiliation: Department of Medical Oncology, Guy's Hospital, St Thomas's Street, London SE1 9RT, UK.
authors.forename: James
authors.initials: J
authors.lastname: Spicer
authors.forename: Alan
authors.initials: A
authors.lastname: Ashworth
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D033942:Adaptor Proteins, Vesicular Transport / Q000378:metabolism; D016764:Cell Polarity / Q000502:physiology*; D006801:Humans; D010580:Peutz-Jeghers Syndrome / Q000235:genetics / Q000503:physiopathology*; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000378:metabolism
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D011500:Protein Synthesis Inhibitors; C476400:STRADA protein, human; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases; C118888:AMP-dependent kinase (ATP-forming); D017856:Phosphotransferases (Phosphate Group Acceptor)