Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi.
We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity.
Ribeiro
Tatiana Santana
TS
Universidade Federal Rural do Rio de Janeiro, Instituto de Ciências Exatas, Departamento de Química, Km 7, BR 465 CEP: 23.890-000, Seropédica, RJ Brazil.
Freire-de-Lima
Leonardo
L
Previato
José Osvaldo
JO
Mendonça-Previato
Lucia
L
Heise
Norton
N
de Lima
Marco Edilson Freire
ME
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D052117:Benzodioxoles; D002478:Cells, Cultured; D014355:Chagas Disease / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D020128:Inhibitory Concentration 50; D021261:Parasitic Sensitivity Tests; D010880:Piperidines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D014344:Trypanocidal Agents; C008922:piperine