A case of hypertrophic osteoarthropathy associated with epithelioid hemangioendothelioma.
Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome characterized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.
Kim
Jin Hyun
JH
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Lee
Eun Bong
EB
Kim
Sunyoung
S
Kang
Hyoun Woo
HW
Suh
Jung Won
JW
Yoon
Won Jae
WJ
Kim
Su Hwan
SH
Kang
Eun Ha
EH
Im
Churl Hyun
CH
Song
Yeong Wook
YW
Lee
Hyo-Suk
HS
D000328:Adult; D001706:Biopsy; D001792:Blood Platelets / Q000378:metabolism; D004727:Endothelium / Q000378:metabolism; D005269:Femur / Q000000981:diagnostic imaging; D018323:Hemangioendothelioma, Epithelioid / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000150:complications* / Q000473:pathology*; D011859:Radiography; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000473:pathology
D042461:Vascular Endothelial Growth Factor A