Techniques for high-throughput characterization of peptides, oligonucleotides and catalysis efficiency.
Combinatorial processes have been widely applied to many disciplines in chemistry and biology. The vast numbers of unique entities generated by combinatorial synthesis have led to the development of high-throughput methods for characterizing samples, to avoid bottlenecks created by the application of conventional, serial-based analytical techniques. In recent years, high-throughput and novel methods utilizing mass spectrometry, multiplexed capillary electrophoresis, various forms of optical detection, and even sound waves have been investigated for a variety of applications.
Kenseth
Jeremy R
JR
CombiSep, Inc., 2711 South Loop Drive, Ames, Iowa 50010, USA.
He
Yan
Y
Tallman
Dennis
D
Pang
Ho-ming
HM
Coldiron
Shelley J
SJ
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends; D015195:Drug Design; D019075:Electrophoresis, Capillary; D013058:Mass Spectrometry; D008422:Materials Testing; D009841:Oligonucleotides / Q000737:chemistry*; D055095:Optics and Photonics / Q000295:instrumentation; D010455:Peptides / Q000737:chemistry*
D009841:Oligonucleotides; D010455:Peptides