[Potency of peroral and parenteral administration of Zinc-DTPA for decorporation of 241Am from the gastrointestinal tract].
An effect of cincacine at three doses (25, 150 and 300 mumol/kg) has been studied in rats receiving 241Am citrate intragastrically. The radionuclide was introduced every other day for 2 weeks. The total content was 925 kBq/kg. A cincacine administration leads to limitation of radionuclide accumulation in the major organs of deposition independent of the modes of intake. At gastrointestinal 241Am intake peroral cincacine administration is more effective in limiting this radionuclide accumulation in skeleton but less effective in reduction of its accumulation in liver compared to parenteral cincacine. No reliable dependence of cincacine efficacy on dosage has been revealed. A morphology study of organs has shown that cincacine ingestion at a dose of 150 mumol/kg for 4 weeks and at a dose of 300 mumol/kg for 2 weeks produces a toxic effect on the small intestine mucosa. 25 mumol/kg is the optimum dose and per os administration of higher doses is not expedient.
Ivannikov
A T
AT
State Research Center-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia. ibphgen@srcibph.ru
Il'in
L A
LA
Zhorova
E S
ES
Popov
B A
BA
Parfenova
I M
IM
D000284:Administration, Oral; D000576:Americium / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001842:Bone and Bones / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007413:Intestinal Mucosa / Q000737:chemistry / Q000187:drug effects / Q000473:pathology; D008297:Male; D004369:Pentetic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D014781:Viscera / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism
D002614:Chelating Agents; D004369:Pentetic Acid; D000576:Americium