Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis.
Bromopolystyrene beads with diameters of up to 600 microm have been derivatized completely, via bromine-magnesium exchange and interception with electrophiles, to yield high quality solid-supported reagents, scavengers and solid supports for use in diversity-oriented synthesis.
Thomas
Gemma L
GL
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
Ladlow
Mark
M
Spring
David R
DR