Fine mapping of milk production QTL on BTA6 by combined linkage and linkage disequilibrium analysis.
Combined linkage and linkage disequilibrium analysis were used to refine the position of a previously detected QTL affecting milk production traits on bovine chromosome 6. Through a series of single- and multitrait and single- and multipoint QTL analyses, the QTL could be positioned to a 7.5-cM interval surrounded by the markers BMS2508 and FBN12. The most significant results were found for fat percentage and protein percentage. This effect seemed to be caused by a QTL allele embedded in one specific marker haplotype that caused a reduction in fat and protein yields and a concomitant increase of milk yield, thus resulting in a marked reduction of fat and protein percentages.
Olsen
H G
HG
Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N-1432 Aas, Norway. hanne-gro.olsen@iha.nlh.no
Lien
S
S
Svendsen
M
M
Nilsen
H
H
Roseth
A
A
Aasland Opsal
M
M
Meuwissen
T H E
TH
D000483:Alleles; D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006239:Haplotypes; D007774:Lactation / Q000235:genetics*; D015810:Linkage Disequilibrium / Q000235:genetics*; D008055:Lipids / Q000032:analysis; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins / Q000032:analysis; D040641:Quantitative Trait Loci / Q000235:genetics*
D008055:Lipids; D008894:Milk Proteins