Relationship between MMR vaccine and autism.
OBJECTIVE
To evaluate the proposed link between the administration of the measles, mumps, and rubella (MMR) vaccine and the development of autism.


METHODS
A literature search utilizing MEDLINE (1966-November 2003), with the key terms measles, mumps, rubella, and autism, was conducted. Review of the references listed in the articles identified was also performed.


RESULTS
Ten articles that specifically evaluated the possible relationship between the MMR vaccine and autism were identified. Review articles, commentaries, and evaluations of a link between gastrointestinal symptoms in autistic children and MMR immunization were excluded.


CONCLUSIONS
Based upon the current literature, it appears that there is no relationship between MMR vaccination and the development of autism.
Klein
Kristin C
KC
Clinical Sciences Department, College of Pharmacy Services, University of Michigan Health System, Ann Arbor, MI 48109-0221, USA. kriklein@umich.edu
Diehl
Emily B
EB
D001321:Autistic Disorder / Q000209:etiology*; D002648:Child; D002986:Clinical Trials as Topic; D006801:Humans; D022542:Measles-Mumps-Rubella Vaccine / Q000009:adverse effects*
D022542:Measles-Mumps-Rubella Vaccine