title: Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose.
abstract: Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epinephrine developed myocardial stunning that was characterized by severe hemodynamic compromise, profound, albeit transient, left ventricular systolic and diastolic dysfunction, and only modestly elevated biochemical markers of myocardial necrosis. Our case illustrates the serious consequences of medical errors that can be avoided through improved medication labeling and staff supervision.
authors.affiliation: Department of Medicine, New Jersey Medical School, Newark, New Jersey, USA.
authors.forename: Navin
authors.initials: N
authors.lastname: Budhwani
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Bonaparte
authors.forename: Aloysius B
authors.initials: AB
authors.lastname: Cuyjet
authors.forename: Muhamed
authors.initials: M
authors.lastname: Saric
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D062787:Drug Overdose; D004837:Epinephrine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008508:Medication Errors / Q000009:adverse effects*; D009515:New Jersey; D014662:Vasoconstrictor Agents / Q000009:adverse effects*; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*
chemical_list: D014662:Vasoconstrictor Agents; D004837:Epinephrine