Preparation of poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels and their drug release behavior.
N-isopropylacrylamide/itaconic acid copolymeric hydrogels were prepared by irradiation of the ternary mixtures of N-isopropylacrylamide/itaconic acid/water by gamma-rays at ambient temperature. The effect of comonomer concentration, irradiation dose and pH on the swelling equilibria were studied. Lidocaine was used as a model drug for the investigation of drug release behaviour of hydrogels. Lidocaine adsorption capacity of the hydrogels were found to increase from 3.6 to 862.1 (mg lidocaine/g dry gel) with increasing amount of itaconic acid in the gel structure. Adsorption and release processes were followed at 4 and 37 degrees C, respectively. The release studies showed that the basic parameters affecting the drug release behaviour of the hydrogels were pH and temperature of the solution and cross-link density of the gels.
Taşdelen
Betül
B
Chemistry Department, Cekmece Nuclear Research and Training Center, 34831, P.O. Box 1, Istanbul, Turkey.
Kayaman-Apohan
Nilhan
N
Güven
Olgun
O
Baysal
Bahattin M
BM
D000180:Acrylic Resins / Q000737:chemistry; D000327:Adsorption; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000737:chemistry; D005720:Gamma Rays; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008012:Lidocaine / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013386:Succinates / Q000737:chemistry; D013696:Temperature
D000180:Acrylic Resins; D000779:Anesthetics, Local; D020100:Hydrogels; D013386:Succinates; C052970:poly-N-isopropylacrylamide; D008012:Lidocaine; C005229:itaconic acid