Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy.
OBJECTIVE
To analyze the histopathology of polypoidal choroidal vasculopathy (PCV) and choroidal neovascularization (CNV) developing from PCV, the authors evaluated correlations between pathological findings and the findings of preoperative indocyanine green angiography (IA).


METHODS
Two specimens were obtained during CNV excision associated with PCV. PCV tissue was excised with the CNV. The specimens were examined by light microscopy.


RESULTS
In one case, IA revealed polypoidal lesions exhibiting hyperfluorescence in both the early and the late phase, and in the affected area, abnormally dilated vessels were identified histologically underneath relatively healthy retinal pigment epithelium (RPE). In the other case, the polypoidal lesions seen on IA showed early hyperfluorescence and late isofluorescence, and dilated vessels were observed under the RPE; perivascular amorphous material was present. The RPE adhered to the side of the choroid, and there was CNV under the neurosensory retina in both cases. The CNV had numerous vascular lumens, was not surrounded by the RPE, and exhibited few fibrous components.


CONCLUSIONS
IA findings vary depending on the condition of the RPE located above the PCV and the extent of amorphous material around the PCV.
Nakajima
Masami
M
Department of Ophthalmology, Nihon University School of Medicine, Surugadai Hospital of Nihon University, Tokyo, Japan. masamin@mail.med.nihon-u.ac.jp
Yuzawa
Mitsuko
M
Shimada
Hiroyuki
H
Mori
Ryusaburo
R
D000368:Aged; D000792:Angiography; D002829:Choroid / Q000098:blood supply*; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000473:pathology; D004396:Coloring Agents; D005453:Fluorescence; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D014652:Vascular Diseases / Q000175:diagnosis* / Q000473:pathology
D004396:Coloring Agents; D007208:Indocyanine Green