How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets.
The effect of roll compaction/dry granulation on the ribbon and tablet properties produced using different magnesium carbonates was evaluated. The ribbon microhardness and the pore size distribution of tablets were used as evaluation factors. Increasing the specific compaction force resulted in higher microhardness for ribbons prepared with all four magnesium carbonates accompanied with decreased part of fine. Consequently, the corresponding produced tablets displayed a lower tensile strength. A possible correlation between the particle shape, surface area and the resulting pore structure of tablets produced with the four different types of magnesium carbonate was observed. The tensile strength of tablets prepared using granules was lower than tensile strength of tablets produced using starting materials. The partial loss of compactibility resulted in a demand of low loads during roll compaction. However, the impact of changes in the material properties during the roll compaction depended greatly on the type of magnesium carbonate, the specific compaction force and the tableting pressure applied.
Freitag
Franziska
F
Institute of Pharmaceutics and Biopharmaceutics, School of Pharmacy, Martin-Luther-University (MLU), Halle-Wittenberg, Germany.
Reincke
Katrin
K
Runge
Jürgen
J
Grellmann
Wolfgang
W
Kleinebudde
Peter
P
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D007287:Inorganic Chemicals / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D013607:Tablets / Q000737:chemistry*
D007287:Inorganic Chemicals; D013607:Tablets; D008628:Mercury