[Effect of safflower injection on cardiac energy charge and anti-apoptosis gene bcl-2 in rats' heart].
OBJECTIVE
To study the effect of safflower injection (SI) in protecting heart, and on energy charge and anti-apoptosis gen bcl-2 in cardiac tissue.


METHODS
Rats' Langendorff isolated heart infused model was used in the experiment to study the effect of SI by measuring the cardiac function, energy charge and bcl-2 expression of the cultured heart in the modified Euro-Collins (mEC) heart preserving liquid with or without addition of SI.


RESULTS
As compared with the control, SI showed the effects of improving functions of cardiac contraction and dilation, increasing coronary blood flow, and strengthening the bcl-2 protein expression.


CONCLUSIONS
SI has excellent effect in protecting heart.
Zhang
Su-qing
SQ
Beijing University of CM, Beijing 100029. zhangsqing@sina.com.cn
Jiang
Liang-duo
LD
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D031187:Carthamus tinctorius / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D019254:Genes, bcl-2 / Q000187:drug effects; D066298:In Vitro Techniques; D007267:Injections; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016277:Ventricular Function, Left / Q000502:physiology
D004365:Drugs, Chinese Herbal; D019253:Proto-Oncogene Proteins c-bcl-2