Clonality of Streptococcus pneumoniae serotype 1 isolates from pediatric patients in the United States.
We compared Streptococcus pneumoniae serotype 1 isolates causing disease among children in six geographic regions of the United States to determine genetic relatedness. Genomic fingerprints were determined by repetitive element polymorphism PCR (Rep-PCR). Multilocus sequence type characterization was performed on selected isolates. Four different genomic banding patterns were identified by Rep-PCR. One profile (clone 1) was predominant and matched sequence type 227.
Gonzalez
Blanca E
BE
Division of Infectious Diseases, Baylor College of Medicine, Texas Children's Hospital, Mail Code 3-2371, 6621 Fannin St., Houston, TX 77030, USA.
Hulten
Kristina G
KG
Kaplan
Sheldon L
SL
Mason
Edward O
EO
D000293:Adolescent; D002648:Child; D006801:Humans; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics*; D014481:United States