title: Calcific neurocysticercosis and epileptogenesis.
abstract: Neurocysticercosis is responsible for increased rates of seizures and epilepsy in endemic regions. The most common form of the disease, chronic calcific neurocysticercosis, is the end result of the host's inflammatory response to the larval cysticercus of Taenia solium. There is increasing evidence indicating that calcific cysticercosis is not clinically inactive but a cause of seizures or focal symptoms in this population. Perilesional edema is at times also present around implicated calcified foci. A better understanding of the natural history, frequency, epidemiology, and pathophysiology of calcific cysticercosis and associated disease manifestations is needed to define its importance, treatment, and prevention.
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. tnash@niaid.nih.gov
authors.forename: T E
authors.initials: TE
authors.lastname: Nash
authors.forename: O H
authors.initials: OH
authors.lastname: Del Brutto
authors.forename: J A
authors.initials: JA
authors.lastname: Butman
authors.forename: T
authors.initials: T
authors.lastname: Corona
authors.forename: A
authors.initials: A
authors.lastname: Delgado-Escueta
authors.forename: R M
authors.initials: RM
authors.lastname: Duron
authors.forename: C A W
authors.initials: CA
authors.lastname: Evans
authors.forename: R H
authors.initials: RH
authors.lastname: Gilman
authors.forename: A E
authors.initials: AE
authors.lastname: Gonzalez
authors.forename: J A
authors.initials: JA
authors.lastname: Loeb
authors.forename: M T
authors.initials: MT
authors.lastname: Medina
authors.forename: S
authors.initials: S
authors.lastname: Pietsch-Escueta
authors.forename: E J
authors.initials: EJ
authors.lastname: Pretell
authors.forename: O M
authors.initials: OM
authors.lastname: Takayanagui
authors.forename: W
authors.initials: W
authors.lastname: Theodore
authors.forename: V C W
authors.initials: VC
authors.lastname: Tsang
authors.forename: H H
authors.initials: HH
authors.lastname: Garcia
mesh_terms: D000818:Animals; D001929:Brain Edema / Q000209:etiology / Q000469:parasitology; D002114:Calcinosis / Q000150:complications / Q000469:parasitology; D003552:Cysticercus / Q000302:isolation & purification / Q000502:physiology; D004828:Epilepsies, Partial / Q000209:etiology* / Q000469:parasitology / Q000503:physiopathology; D016266:Food Parasitology; D006801:Humans; D007843:Latin America / Q000453:epidemiology; D020019:Neurocysticercosis / Q000150:complications* / Q000453:epidemiology / Q000469:parasitology / Q000517:prevention & control / Q000635:transmission; D041201:Taenia solium / Q000502:physiology