Consequences of human cytomegalovirus mimicry.
The HCMV genome has evolved with its host by incorporating a series of genes that are homologous to, or functionally mimic, cellular genes. Some are designed to counteract the stress of infection on the host cell, notably the viral antiapoptotic proteins (vICA, vMIA). Others potentially help the infected cell maintain a low immunologic profile. These include virus-encoded chemokine receptors (UL33, UL78, US27, US28), FcRs (gp TRL11/IRL11, gp UL119-118), and proteins that directly or indirectly thwart natural killer cell activity (UL16, gpUL40). In addition, some viral proteins may play a role in immunopathology because of fortuitous cross-reactivity with host cell proteins. This overview discusses how these proteins affect the life of the host cell and its immediate neighbors.
Michelson
Susan
S
Unité d'Immunologie Virale, Institut Pasteur, Paris, France. michelson@wanadoo.fr
D017209:Apoptosis / Q000276:immunology / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D003429:Cross Reactions / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000276:immunology / Q000378:metabolism / Q000821:virology; D058851:GPI-Linked Proteins; D006023:Glycoproteins / Q000378:metabolism / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D006801:Humans; D017874:Immediate-Early Proteins / Q000502:physiology; D007074:Immunoglobulin G / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins; D008954:Models, Biological; D018716:Molecular Mimicry / Q000276:immunology / Q000502:physiology*; D019707:Receptors, Chemokine / Q000502:physiology; D011961:Receptors, Fc / Q000276:immunology / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014764:Viral Proteins / Q000378:metabolism / Q000502:physiology*
D002352:Carrier Proteins; D058851:GPI-Linked Proteins; D006023:Glycoproteins; D015395:Histocompatibility Antigens Class I; C088645:IE1 protein, cytomegalovirus; D017874:Immediate-Early Proteins; D007074:Immunoglobulin G; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D019707:Receptors, Chemokine; D011961:Receptors, Fc; D017452:Receptors, IgG; C464820:UL119-UL118 glycoprotein, Human cytomegalovirus; C461643:UL33 protein, human cytomegalovirus; C078035:UL36 protein, Human herpesvirus 1; C420323:UL37 protein, Human herpesvirus 5; C404228:UL40 glycoprotein, Cytomegalovirus; C423231:ULBP1 protein, human; C411191:US28 receptor, Cytomegalovirus; D014764:Viral Proteins; C104832:gp34 protein, cytomegalovirus