title: Pharmacokinetics of indinavir in Koreans and Caucasians.
abstract: We evaluated whether the pharmacokinetic parameters of indinavir differ in Koreans and Caucasians. Indinavir was administered orally to 8 healthy Koreans and 4 healthy Caucasians, and plasma indinavir levels were quantified by high performance liquid chromatography. No significant differences were observed in terms of its pharmacokinetic parameters; however, the AUC difference between the 2 groups may be significant for larger sample sizes.
authors.affiliation: Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Chang
authors.forename: Yoon Soo
authors.initials: YS
authors.lastname: Park
authors.forename: Cheong Ho
authors.initials: CH
authors.lastname: Cho
authors.forename: So Youn
authors.initials: SY
authors.lastname: Shin
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim
mesh_terms: D000328:Adult; D019540:Area Under Curve; D044466:Asian People; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D044465:White People
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir