[Gene expression changes of cartilage matrix of condylar cartilage with anterior disc displacement].
OBJECTIVE
To study the gene expression changes in extracellular matrix of condylar cartilage following disc anterior displacement of rabbit TMJ.


METHODS
The right sides of 28 joints in 40 rabbits were subjected to surgical operation of disc displacement. The condylar Collagen II and Aggrecan mRNA expression were detected by in situ hybridization.


RESULTS
Collagen II and Aggrecan mRNA mainly expressed in the lower zone of condylar chondrocyte. Aggrecan mRNA decreased faster than collagen II following disc displacement, and adjusted to normal later.


CONCLUSIONS
Anterior disc displacement leads to alteration of extracellurar matrix gene expression in the condylar chondrocyte, which means the start of remodeling.
Feng
Jian-ying
JY
Dept. of Orthodontics, Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Zhang
Kai
K
Gu
Zhi-yuan
ZY
Shibata
Takanori
T
D053674:Aggrecans; D000818:Animals; D016723:Bone Remodeling; D002358:Cartilage, Articular / Q000166:cytology; D019902:Chondrocytes / Q000378:metabolism*; D024043:Collagen Type II / Q000096:biosynthesis* / Q000235:genetics; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D017403:In Situ Hybridization; D037181:Lectins, C-Type; D008297:Male; D008335:Mandibular Condyle / Q000166:cytology / Q000378:metabolism*; D011509:Proteoglycans / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011817:Rabbits; D013704:Temporomandibular Joint / Q000166:cytology / Q000378:metabolism; D019224:Temporomandibular Joint Disc / Q000601:surgery; D013705:Temporomandibular Joint Disorders / Q000209:etiology / Q000235:genetics* / Q000378:metabolism
D053674:Aggrecans; D024043:Collagen Type II; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D011509:Proteoglycans; D012333:RNA, Messenger