title: Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin.
abstract: A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin.
authors.affiliation: Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. srivaric@iict.res.in
authors.forename: S
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: V
authors.initials: V
authors.lastname: Jagadeshwar
authors.forename: Ch
authors.initials: Ch
authors.lastname: Narsihmulu
authors.forename: M
authors.initials: M
authors.lastname: Sarangapani
authors.forename: D R
authors.initials: DR
authors.lastname: Krishna
authors.forename: J
authors.initials: J
authors.lastname: Vidyasagar
authors.forename: Dolly
authors.initials: D
authors.lastname: Vijay
authors.forename: G Narahari
authors.initials: GN
authors.lastname: Sastry
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001665:Binding Sites; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D014404:Tubulin; C109551:eleutherobin