Synthesis and cytotoxic activity of 1-(1-benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones.
The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.
Jung
Sang-Hun
SH
College of Pharmacy, Chungnam National University, Taejon 305-764, Korea. jungshh@cnu.ac.kr
Lee
Hui-Soon
HS
Kim
Nam-Soo
NS
Kim
Hwan-Mook
HM
Lee
Moonsun
M
Choi
Dong-Rack
DR
Lee
Jung-Ah
JA
Chung
Yong-Ho
YH
Moon
Eun-Yi
EY
Hwang
Hyun-Sook
HS
Seong
Seung-Kyoo
SK
Lee
Dug-Keun
DK
D000818:Animals; D045744:Cell Line, Tumor; D006801:Humans; D048289:Imidazolidines / Q000138:chemical synthesis* / Q000633:toxicity*; D051379:Mice
D048289:Imidazolidines