Lack of evidence of encephalopathy related to pertussis vaccine: active surveillance by IMPACT, Canada, 1993-2002.
To assess whether pertussis-containing vaccines cause encephalitis or encephalopathy, the IMPACT network of Canadian pediatric centers screened more than 12,000 admissions for neurologic disorders between 1993 and 2002. Seven cases of encephalopathy began within 7 days after pertussis vaccination, but a more likely cause was found in each instance. No attributable case followed administration of >6.5 million doses of vaccine.
Moore
Dorothy L
DL
Montreal Children's Hospital, McGill University Health Centre, Quebec, Canada. dorothy.moore@muhc.mcgill.ca
Le Saux
Nicole
N
Scheifele
David
D
Halperin
Scott A
SA
D017677:Age Distribution; D002170:Canada / Q000453:epidemiology; D002675:Child, Preschool; D003625:Data Collection; D004660:Encephalitis / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D020258:Neurotoxicity Syndromes / Q000453:epidemiology / Q000209:etiology*; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D014917:Whooping Cough / Q000517:prevention & control
D010567:Pertussis Vaccine