title: Use of polylactide resorbable film as a barrier to postoperative peridural adhesion in an ovine dorsal laminectomy model.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the performance of a resorbable polylactide film in the sheep posterior spine in the presence of a combined laminectomy and durotomy defect.
  
  
  METHODS
  A resorbable polylactide film was used to cover the combined defects in the eight sheep used in this study. Two surgical levels were performed in each animal, with randomly assigned control and treated sites. Each surgical level consisted of a full laminectomy followed by a needle-induced durotomy. The treated levels received a resorbable polylactide film cut to size and tucked in under the laminar defect. At 8 to 10 weeks postoperatively, results of myelography and visual dye infiltration showed complete healing of the durotomies for all sites. In addition, evaluation of gross dissection based on volume and tenacity scores as well as histological findings indicates decreased posterior dural adhesions for sites treated with resorbable polylactide film.
  
  
  CONCLUSIONS
  The results of this investigation support previous studies in which the use of a resorbable polylactide film was found to be effective in reducing posterior dural adhesions in the spine with no apparent safety issues related to impaired dural healing.
authors.affiliation: College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Veterinary Teaching Hospital Fort Collins, Colorado 80523, USA. lklopp@colostate.edu
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Klopp
authors.forename: William C
authors.initials: WC
authors.lastname: Welch
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Tai
authors.forename: Jeffery M
authors.initials: JM
authors.lastname: Toth
authors.forename: G Bryan
authors.initials: GB
authors.lastname: Cornwall
authors.forename: A Simon
authors.initials: AS
authors.lastname: Turner
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004195:Disease Models, Animal; D004210:Dissection; D004388:Dura Mater / Q000473:pathology; D005355:Fibrosis / Q000473:pathology; D007796:Laminectomy / Q000009:adverse effects / Q000295:instrumentation*; D008159:Lumbar Vertebrae / Q000601:surgery; D008422:Materials Testing; D009192:Myelography; D011091:Polyesters; D011183:Postoperative Complications / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D012756:Sheep; D013904:Thoracic Vertebrae / Q000601:surgery; D000267:Tissue Adhesions / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D014945:Wound Healing
chemical_list: D011091:Polyesters; C033616:poly(lactide)