Endometrial morphology and pituitary-gonadal axis dysfunction in women of reproductive age undergoing chronic haemodialysis--a multicentre study.
BACKGROUND
Although disorders of the reproductive system are very common in women undergoing chronic haemodialysis, this issue remains a neglected area. The aim of the study was to evaluate the endometrial morphology and its relationship with pituitary-gonadal axis dysfunction in uraemic women of reproductive age undergoing haemodialysis.


METHODS
The baseline survey with determination of the sex hormones concentrations was performed in 75 haemodialysed women aged 18-45 years. The control group consisted of 33 healthy premenopausal women, aged 18-45 years, with normal menstruation. Then, 40 haemodialysis women, who met the inclusion criteria and gave their informed consent, underwent endometrium suction biopsy.


RESULTS
The pathological endometrial morphology was observed in 80% of biopsied subjects. Atrophia or subatrophia was recognized in almost half of the cases, and proliferative changes in one-third of them. Full atrophia with no mitotic figures was found in all but one non-menstruating woman. In one case, adenocarcinoma in situ was diagnosed and successfully treated. The analysis of the relationship between hormonal status and endometrial morphology revealed the substantial influence of oestradiol on endometrium as a target organ. In women with atrophic changes, oestradiol concentrations were significantly decreased, whereas in the remaining subjects, the increase of serum oestradiol seemed to be accompanied by a shift in endometrium morphology from secretional pattern, through proliferative changes to glandular hyperplasia. Mean serum 17-beta oestradiol was decreased in women with amenorrhoea, and increased in those with eumenorrhoea (P<0.001). Except women with regular menses, mean serum progesterone concentrations were in the lower normal range. Seventy-five percent of the studied population had menstrual disorders, and amenorrhoea constituted almost a half of them.


CONCLUSIONS
Pathological endometrium morphology is very common in uraemic women of reproductive age undergoing haemodialysis, with proliferative changes in one-third and atrophia in almost a quarter of them. The results of the study suggest a preserved normal reactivity of endometrium on circulating oestrogens.
Matuszkiewicz-Rowinska
Joanna
J
Department of Internal Medicine and Nephrology, Medical University of Warsaw, Poland. jotmatrow@tlen.pl
Skórzewska
Katarzyna
K
Radowicki
Stanislaw
S
Niemczyk
Stanislaw
S
Sokalski
Antoni
A
Przedlacki
Jerzy
J
Puka
Janusz
J
Switalski
Marek
M
Wardyn
Kazimierz
K
Grochowski
Janusz
J
Ostrowski
Kazimierz
K
D000293:Adolescent; D000328:Adult; D001284:Atrophy; D015897:Comorbidity; D004717:Endometrium / Q000473:pathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008599:Menstruation Disturbances / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D006435:Renal Dialysis; D014511:Uremia / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone