Impact of gene polymorphisms on depression and its treatment.
Various genetic alterations have been demonstrated to be associated with mood disorders and suicide in a number of studies, although there are many contradictory findings. The most studied genotype, with the largest number of replicated results, is the serotonin transporter genotype. The efficacy of antidepressants appears to be influenced by the presence of a functional polymorphism within the serotonin transporter gene. In addition, genetic variation has an influence on the occurrence of antidepressant-induced side effects. Although further studies using larger sample populations are needed, it is becoming clear that genetic tools will be a major factor in improving diagnosis and optimizing the treatment of depressive disorders in the near future.
Moret
Chantel
C
NeuroBiz Consulting and Communications, Les Grèzes, La Verdarié, 81100 Castres, France. chantal.moret@neurobiz.com
D000928:Antidepressive Agents / Q000009:adverse effects / Q000494:pharmacology; D003866:Depressive Disorder / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy*; D006801:Humans; D019964:Mood Disorders / Q000235:genetics / Q000628:therapy; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000502:physiology*; D013405:Suicide
D000928:Antidepressive Agents