title: Resuscitation of a defective prophage in Salmonella cocultures.
abstract: Widely studied Salmonella enterica serovar Typhimurium strains ATCC 14028s and SL1344 harbor a cryptic ST64B prophage unable to produce infectious virions. We found that coculturing either strain with an isogenic sibling lacking the prophage leads to the appearance of active forms of the virus. Active phage originates from reversion of a +1 frameshift mutation at a monotonous G:C run in a presumptive tail assembly pseudogene.
authors.affiliation: Centre de Génétique Moléculaire, CNRS, 91198 Gif-sur-Yvette cedex, France. figueroa@cgm.cnrs-gif.fr
authors.forename: Nara
authors.initials: N
authors.lastname: Figueroa-Bossi
authors.forename: Lionello
authors.initials: L
authors.lastname: Bossi
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D016368:Frameshift Mutation; D008969:Molecular Sequence Data; D039002:Prophages / Q000235:genetics / Q000502:physiology*; D012483:Salmonella Phages / Q000235:genetics / Q000502:physiology*; D012486:Salmonella typhimurium / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics; D014775:Virus Activation
chemical_list: D014764:Viral Proteins