[The relationship of angiotensin I-converting enzyme gene polymorphism with diabetic retinopathy and diabetes myocardial infarction].
OBJECTIVE
To investigate the relationship of angiotensin I-converting enzyme (ACE) gene polymorphism to diabetic retinopathy and diabetes myocardial infarction.


METHODS
ACE insertion/deletion(I/D) polymorphism was determined by PCR.


RESULTS
No evidence showed that ACE gene was associated with diabetic retinopathy. By comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant (P<0.05).


CONCLUSIONS
Allele D(RR=1.50) and genotype DD(RR=1.33) seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.
Wu
Shou-shan
SS
Department of Biotechnology, North China Coal Medical College, Tangshan, Hebei, 063000 PR China. Ts-wss@163.com
Guo
Qing-mei
QM
Liu
Ge-ling
GL
Zhang
Juan
J
Zhao
Chen-fu
CF
Ning
Shu-cheng
SC
Zhao
Li-na
LN
Yu
Fang
F
Yi
Hong-li
HL
D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D007703:Peptidyl-Dipeptidase A