[Significance of detecting urinary monocyte chemotactic peptide-1 in renal transplant recipient].
OBJECTIVE
To detect the content of monocyte chemotactic peptide-1(MCP-1) and to investigate the role of MCP-1 in acute renal graft rejection.


METHODS
Urinary MCP-1 level was detected by avidin biotin complex(ABC)ELISA.


RESULTS
Urinary MCP-1 levels in renal function stable renal transplantation of recipients and control group were (416+/-21) microg/L and (408+/-11) microg/L, respectively. Urinary MCP-1 level in renal transplantation recipients with acute rejection was (1195+/-58) microg/L, which was notably higher than that in control group and renal function stable recipients (P<0.01). After anti-rejection treatment, urinary MCP-1 level decreased markedly in patients who responded to treatment.


CONCLUSIONS
The urinary MCP-1 level is correlated closely with acute renal graft rejection and its increase may indicate ongoing acute renal rejection. Detection of urinary MCP-1 level may contribute to early diagnosis and prognostic judgement of acute graft rejection.
Sun
Xing-hui
XH
Department of Urology, Fuzhou General Hospital of Nanjing Military Area, Fuzhou 350025, China.
Tan
Jian-ming
JM
Wu
Wei-zhen
WZ
Lin
Wen-hong
WH
Li
Qian-sheng
QS
Fang
Yu-hua
YH
D000208:Acute Disease; D000328:Adult; D018932:Chemokine CCL2 / Q000502:physiology / Q000652:urine*; D005260:Female; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D018932:Chemokine CCL2