title: Interference of Uzara glycosides in assays of digitalis glycosides.
abstract: OBJECTIVE
  Presentation of a case report and pharmacokinetic investigation in healthy volunteers on the potential interference between cardiac glycosides and glycosides of Uzara, a herbal antidiarrheal preparation.
  
  
  METHODS
  Pharmacokinetic pilot investigation of apparent digitoxin and digoxin serum concentrations in 4 healthy volunteers after single-dose administration of 30 drops Uzara (approximately 1.5 ml approximately = 22 mg glycosides).
  
  
  RESULTS
  Maximal apparent serum concentrations of digitoxin between 198.0 microg/l and 919.8 microg/l (therapeutic range: 10-25 microg/l) occurred at 4-8 hours after administration. The terminal half-life of the glycosides was 8.87 +/- 2.20 hours. For digoxin, maximal apparent serum concentrations ranged between 1.4 microg/l and 6.34 microg/l (therapeutic range: 0.9-2.0 microg/l) at 6 hours post dosing.
  
  
  CONCLUSIONS
  Administration of a single dose of an Uzara preparation, an over-the-counter product, results in false high serum concentrations of digitoxin and digoxin. As described in the manufacturers Summary of Product Characteristics, this preparation should not be given to patients with cardiac failure or arrhythmia who require treatment with cardiac glycosides because of the demonstrated pharmacological actions of uzara glycosides.
authors.affiliation: Philipp Klee Institute of Clinical Pharmacology, Helios Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany. pthuermann@wuppertal.helios-kliniken.de
authors.forename: P A
authors.initials: PA
authors.lastname: Thürmann
authors.forename: A
authors.initials: A
authors.lastname: Neff
authors.forename: J
authors.initials: J
authors.lastname: Fleisch
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000097:blood*; D000930:Antidiarrheals / Q000097:blood*; D029062:Apocynaceae / Q000737:chemistry*; D004074:Digitoxin / Q000097:blood; D004077:Digoxin / Q000097:blood; D005189:False Positive Reactions; D005260:Female; D006027:Glycosides / Q000097:blood*; D006207:Half-Life; D041743:Herb-Drug Interactions; D006801:Humans; D008297:Male; D010865:Pilot Projects; D010936:Plant Extracts / Q000097:blood; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000889:Anti-Arrhythmia Agents; D000930:Antidiarrheals; D006027:Glycosides; D010936:Plant Extracts; D004077:Digoxin; D004074:Digitoxin