DCs as targets for vaccine design.
The increasingly stringent requirements laid down by regulatory authorities have brought to an end the largely empirical design of vaccines. Vaccines must now be designed rationally, in order that appropriate immune responses are elicited with few or no side effects. The DC plays a pivotal role in determining the type of immune response that ensues following exposure of the host to an Ag. In this review, we identify some of the features and properties of DCs, and how these properties can be exploited in the design of smart vaccines.
Belz
Gt
G
Cooperative Research Centre for Vaccine Technology, Department of Microbiology and Immunology, The University of Melbourne, Victoria, Parkville, Australia.
Smith
Cm
C
Bharadwaj
M
M
Rice
Am
A
Jackson
Dc
D
D019264:Adoptive Transfer; D017951:Antigen Presentation / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002450:Cell Communication / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D006649:Histocompatibility Antigens / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D013601:T-Lymphocytes; D014612:Vaccines / Q000276:immunology*
D015703:Antigens, CD; D006649:Histocompatibility Antigens; D011956:Receptors, Cell Surface; D014612:Vaccines