Gag order.
The Polycomb group (PcG) complex mediates heritable silencing of numerous genes during development. In a recent issue of Molecular Cell, Wang et al. (2004) characterize the order of PcG protein recruitment to specific regions of Ubx and substantiate a binding-in trans looping model of repression that may interfere with transcription initiation or elongation.
Champion
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D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics*; D063150:Polycomb Repressive Complex 1; D011401:Promoter Regions, Genetic; D034622:RNA Interference; D037941:Silencer Elements, Transcriptional / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics*; D024363:Transcription Initiation Site
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; C066770:Pc protein, Drosophila; D014157:Transcription Factors; C066177:Ubx protein, Drosophila; D063150:Polycomb Repressive Complex 1