Synthesis of aldehydo-sugar derivatives of pyrazoloquinoline as inhibitors of herpes simplex virus type 1 replication.
Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.
Bekhit
Adnan A
AA
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
El-Sayed
Ola A
OA
Aboul-Enein
Hassan Y
HY
Siddiqui
Yunus M
YM
Al-Ahdal
Mohammed N
MN
D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002241:Carbohydrates / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005840:Gentian Violet; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013194:Staining and Labeling; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute; D014779:Virus Replication / Q000187:drug effects*
D000447:Aldehydes; D000998:Antiviral Agents; D002241:Carbohydrates; D011720:Pyrazoles; D011804:Quinolines; D005840:Gentian Violet