title: Association study of serotonin-2A receptor gene polymorphism and panic disorder in patients from Canada and Germany.
abstract: The T102C serotonin-2A (5-HT2A) receptor gene polymorphism has been studied extensively in a number of complex psychiatric conditions with mixed results. Recently a genetic association has been described between this polymorphism and panic disorder in a Japanese sample. To evaluate the impact of the T102C polymorphism in panic disorder we genotyped triad families (panic disorder patient and parents), and cases with controls in Canadian and German samples. No significant transmission disequilibrium was observed between the alleles of the T102C 5-HT2A receptor gene polymorphism and panic disorder, nor was a significant excess of either allele found in the case control analysis. Our data suggest thus that this polymorphism is unlikely to play a major role in the pathogenesis of panic disorder.
authors.affiliation: Department of Psychiatry, University of Ottawa and the University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Ottawa, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Rothe
authors.forename: D
authors.initials: D
authors.lastname: Koszycki
authors.forename: J
authors.initials: J
authors.lastname: Bradwejn
authors.forename: N
authors.initials: N
authors.lastname: King
authors.forename: V
authors.initials: V
authors.lastname: De Luca
authors.forename: S
authors.initials: S
authors.lastname: Shaikh
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: H
authors.initials: H
authors.lastname: Garritsen
authors.forename: J
authors.initials: J
authors.lastname: Fritze
authors.forename: J
authors.initials: J
authors.lastname: Deckert
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000483:Alleles; D002170:Canada; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003545:Cysteine / Q000235:genetics; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D013912:Threonine / Q000235:genetics
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D013912:Threonine; D003545:Cysteine