[Modifying influence of iodine deficiency on radiation damage to the fetus (review)].
It known an oppressing action of radiation, including radioactive iodine isotopes on the reproductive system and fetus development. There are clinical data on a negative influence of iodine deficiency on the course of pregnancy and fetus development resulting from hormonal disfunction of thyroid gland and a mother-fetus system. There are no data about a character and mechanisms of interaction of radiation and iodine endemia at the combined action on the gonads and fetus. The urgency of this problem is caused by the fact that many regions of the country are characterized to some extent by iodine deficiency in local food and water (in Russian Federation such regions make approximately 50% of territories), and the opportunity of radiation accidents at nuclear plants with contamination of the environment with products of nuclear division (significant part of which is radioactive iodine isotopes is an objective reality. The analysis of a few published and own experimental data allows us to conclude that the combined influence of an external gamma-irradiation and iodine deficiency on reproductive function has a synergic character.
Liaginskaia
A M
AM
State Research Centre-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia. ibphgen@srcibph.ru
Osipov
V A
VA
D000818:Animals; D000831:Animals, Newborn; D005314:Embryonic and Fetal Development / Q000528:radiation effects; D005260:Female; D005333:Fetus / Q000473:pathology / Q000528:radiation effects*; D005720:Gamma Rays; D006066:Gonads / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000502:physiology*; D007457:Iodine Radioisotopes; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology / Q000528:radiation effects*; D012426:Russia; D013961:Thyroid Gland / Q000502:physiology / Q000528:radiation effects; D013963:Thyroid Hormones / Q000172:deficiency
D007457:Iodine Radioisotopes; D013963:Thyroid Hormones; D007455:Iodine