title: Brain perfusion in children: evolution with age assessed by quantitative perfusion computed tomography.
abstract: OBJECTIVE
  The objective of this study was to assess the age-related variations of brain perfusion through quantitative cerebral perfusion computed tomography (CT) results in children without brain abnormality.
  
  
  METHODS
  Brain perfusion CT examinations were performed in 77 children, aged 7 days to 18 years. These patients were admitted at our institution for both noncontrast and contrast-enhanced cerebral CT. Only children whose conventional cerebral CT and clinical/radiologic follow-up, including additional investigations, were normal were taken into account for this study (53 of 77).
  
  
  RESULTS
  The average regional rCBF amounts to 40 (mL/100 g per minute) for the first 6 months of life, peaks at approximately 130 (mL/100 g per minute) at approximately 2 to 4 years of age, and finally stabilizes at approximately 50 (mL/100 g per minute) at approximately 7 to 8 years of age, with a small increase of rCBF values at approximately 12 years of age. The rCBF in the gray matter averages 3 times that in the white matter, except for the first 6 months of life. The global CBF represents 10% to 20% of the global cardiac output for the first 6 months of life, peaks at approximately 55% by 2 to 4 years of age, and finally stabilizes at approximately 15% by 7 to 8 years of age. Specific age-related evolution patterns were identified in the different anatomic areas of the cerebral parenchyma, which could be related to the development of neuroanatomic structures and to the emergence of corresponding cognitive functions.
  
  
  CONCLUSIONS
  Quantitative perfusion CT characterization of brain perfusion shows specific age variations. Brain perfusion of each cortical area evolves according to a specific time course, in close correlation with the psychomotor development.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital, Lausanne, Switzerland. max_wintermark@hotmail.com
authors.forename: Max
authors.initials: M
authors.lastname: Wintermark
authors.forename: Domenico
authors.initials: D
authors.lastname: Lepori
authors.forename: Jacques
authors.initials: J
authors.lastname: Cotting
authors.forename: Eliane
authors.initials: E
authors.lastname: Roulet
authors.forename: Guy
authors.initials: G
authors.lastname: van Melle
authors.forename: Reto
authors.initials: R
authors.lastname: Meuli
authors.forename: Philippe
authors.initials: P
authors.lastname: Maeder
authors.forename: Luca
authors.initials: L
authors.lastname: Regli
authors.forename: Francis R
authors.initials: FR
authors.lastname: Verdun
authors.forename: Thierry
authors.initials: T
authors.lastname: Deonna
authors.forename: Pierre
authors.initials: P
authors.lastname: Schnyder
authors.forename: François
authors.initials: F
authors.lastname: Gudinchet
mesh_terms: D000293:Adolescent; D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008962:Models, Theoretical; D014057:Tomography, X-Ray Computed / Q000379:methods*