Postnatal refinement of peripheral olfactory projections.
Axonal projections from the olfactory epithelium to the olfactory bulb are organized into glomeruli according to the expressed odorant receptor. Using gene-targeted mice, we show that glomerular maturation proceeds along different time courses for two similar receptors and requires sensory input during distinct sensitive periods. During early development, some glomeruli are innervated by axons of neurons that do not express the same receptor. These heterogeneous glomeruli normally disappear with age, but they persist in adults deprived of sensory input by unilateral and permanent naris closure. Persistence may be due, in part, to prolonged survival of olfactory sensory neurons.
Zou
Dong-Jing
DJ
Department of Biological Sciences, Columbia University, New York, NY 10027, USA. dz98@columbia.edu
Feinstein
Paul
P
Rivers
Aimée L
AL
Mathews
Glennis A
GA
Kim
Ann
A
Greer
Charles A
CA
Mombaerts
Peter
P
Firestein
Stuart
S
D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D016923:Cell Death; D002470:Cell Survival; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D018390:Gene Targeting; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development*; D009833:Olfactory Pathways; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000502:physiology*; D018035:Receptors, Odorant / Q000235:genetics / Q000378:metabolism*; D012683:Sensory Deprivation; D012903:Smell; D013569:Synapses / Q000648:ultrastructure
D018035:Receptors, Odorant