title: Effects of risperidone on destructive behavior of persons with developmental disabilities: III. Functional analysis.
abstract: Functional analyses were conducted during a double-blind, placebo-controlled study of the atypical antipsychotic medication risperidone with 13 individuals. Risperidone was effective in reducing destructive behavior (compared to placebo) for 10 participants. For 7 of these responders, an undifferentiated pattern of responding occurred across their baseline functional analysis conditions (i.e., a similar rate of responding across conditions), and risperidone treatment produced nonspecific reductions of their destructive behavior across functional analysis conditions. For the remaining 3 responders, a differentiated pattern of responding occurred across their baseline functional analysis conditions (i.e., an elevated rate of responding occurred in a specific condition), and risperidone treatment produced function-specific reductions of their destructive behavior.
authors.affiliation: Department of Psychiatry, University of Kansas, University of Kansas Medical Center, Kansas City 66160-7341, USA. JZarcone2@kumc.edu
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Zarcone
authors.forename: Steven E
authors.initials: SE
authors.lastname: Lindauer
authors.forename: Paige S
authors.initials: PS
authors.lastname: Morse
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Crosland
authors.forename: Maria G
authors.initials: MG
authors.lastname: Valdovinos
authors.forename: Todd L
authors.initials: TL
authors.lastname: McKerchar
authors.forename: R
authors.initials: R
authors.lastname: Matthew Reese
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Hellings
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Schroeder
mesh_terms: D000328:Adult; D000374:Aggression / Q000187:drug effects*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002648:Child; D002658:Developmental Disabilities / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D016032:Randomized Controlled Trials as Topic; D018967:Risperidone / Q000627:therapeutic use*; D016728:Self-Injurious Behavior / Q000150:complications / Q000517:prevention & control*
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone