[New concepts on the physiopathology and therapy of aortic stenosis].
Calcified "degenerative" aortic stenosis is currently the most common valvulopathy in industrialised countries. In the course of the last decade, experimental studies have allowed a better understanding of the physiopathology of this vavlulopathy. The latest development is the evidence for the initiation and progression of this disease, similar to those described for atherosclerosis. Lipid disturbances, in particular hypercholesterolaemia, constitute an important factor in the initiation of valvular lesions, but also in aortic orifice calcification. Certain preliminary clinical studies are in favour of the significance of statins for slowing the progression of aortic stenosis. This potential beneficial effect requires confirmation by randomised prospective studies and raises hopes for medical therapy in order to avoid the evolution of ordinary aortic sclerosis into tight calcified aortic stenosis.
Peltier
M
M
Service de cardiologie B, CHRU d'Amiens, hôpital Sud, Amiens. peltier.marcel@chu-amiens.fr
Enriquez-Sarano
M
M
Slama
M
M
Tribouilloy
Ch
Ch
D001024:Aortic Valve Stenosis / Q000188:drug therapy* / Q000503:physiopathology*; D002114:Calcinosis / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000503:physiopathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors