title: Presenilin dysfunction leads to memory and plasticity defects.
authors.forename: Peter
authors.initials: P
authors.lastname: Hayward
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008565:Membrane Proteins / Q000172:deficiency / Q000235:genetics* / Q000378:metabolism; D008569:Memory Disorders / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D051379:Mice; D009473:Neuronal Plasticity / Q000235:genetics*; D053764:Presenilin-1; D053766:Presenilin-2; D016194:Receptors, N-Methyl-D-Aspartate / Q000172:deficiency / Q000235:genetics
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D016194:Receptors, N-Methyl-D-Aspartate