title: Biomechanical interaction between cap thickness, lipid core composition and blood pressure in vulnerable coronary plaque: impact on stability or instability.
abstract: BACKGROUND
  A 'thin' fibrous cap atheroma is the typical morphological characteristic of vulnerable plaque. Yet the very pathological studies that have provided these descriptions have also shown the actual prediction of plaque rupture to be rather less exact. Other relevant characteristics must be involved in the mechanisms of plaque rupture--blood pressure loading (P) and the material properties of the soft atheromatous core--as predictors of the distribution of the peak circumferential stress (PCS) locations.
  
  
  RESULTS
  We used a computational structural analysis based on three typical in-vivo intravascular ultrasound images of fibrous cap atheroma in which we decreased the cap thickness (CTh). With different soft atheromatous core Young's moduli (Ecore), 414 simulations were performed under eight different physiological loading blood pressures. The transition from plaque stability to plaque instability was defined by a threshold of 300 kPa and is a feature of vulnerability. It was found that (1) irrespective of plaque geometry and composition, CTh < 60 microm exposed the plaque to PCSs in excess of 300 kPa; (2) the exponential variations in PCS with change in CTh and Ecore values show that very slight structural changes are enough to tilt a vulnerable plaque from stability to instability or vice versa; and (3) the relationship between P and PCS is proportional with P acting as trigger or as protector.
  
  
  CONCLUSIONS
  The present study shows why, in clinical practice, mere morphological detection by imaging techniques of thin-cap fibro-atheroma is not in itself enough for the prediction of future rupture.
authors.affiliation: Department of Hemodynamics and Interventional Cardiology, Hospices Civils de Lyon and Claude Bernard University and CREATIS, Research Unit associated to CNRS (UMR 5515) and affiliated to INSERM, Lyon, France. gerard.finet@creatis.univ-lyon1.fr
authors.forename: Gérard
authors.initials: G
authors.lastname: Finet
authors.forename: Jacques
authors.initials: J
authors.lastname: Ohayon
authors.forename: Gilles
authors.initials: G
authors.lastname: Rioufol
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D005355:Fibrosis; D006801:Humans; D050356:Lipid Metabolism; D008955:Models, Cardiovascular; D013223:Statistics as Topic; D018084:Ultrasonography, Interventional