Vitamin D deficiency, bone mineral density and weight in patients with advanced pulmonary disease.
OBJECTIVE
To study the influence of underweight, body composition and vitamin D deficiency on bone mineral density in patients with advanced pulmonary disease.


METHODS
Cross-sectional study with time span for inclusion set at 5 years.


METHODS
The clinical work and biochemical analyses were carried out at Rikshospitalet University Hospital, Norway. Analyses for vitamin D metabolites and bone markers were carried out at Aker University Hospital, and bone measurements at Clinic of Osteoporosis.


METHODS
Seventy-one candidates for lung transplantation (63% chronic obstructive pulmonary disease, 42 underweight and 29 normal weight) were included.


METHODS
Body composition, bone mineral density at lumbar spine and femur neck, serum concentration of calcidiol and vitamin D intake.


RESULTS
Subnormal calcidiol levels were present in 52% of the underweight patients and 69% of the normal-weight patients. The resulting models of linear regression showed that for the lumbar spine T scores model, the total variation of 16.7% was explained by group (underweight/normal weight), sex and age. For the femur neck T scores model, the total variation of 20.4% was explained by the interaction of underweight and vitamin D deficiency (with borderline significance) and by arm muscle circumference percentage of standard. In patients with normal calcidiol levels, the median intake of vitamin D was 17 microg in the underweight patients and 11 microg in the normal-weight patients.


CONCLUSIONS
Vitamin D deficiency was common in both underweight and normal-weight patients, but only in the underweight patients, an association between vitamin D deficiency and reduced femur neck T scores was indicated.
Førli
L
L
Department of Respiratory Medicine, Rikshospitalet, Oslo, Norway. liv.forli@rikshospitalet.no
Halse
J
J
Haug
E
E
Bjørtuft
Ø
Ø
Vatn
M
M
Kofstad
J
J
Boe
J
J
D000328:Adult; D001823:Body Composition; D015519:Bone Density; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D012044:Regression Analysis; D014808:Vitamin D Deficiency / Q000150:complications*; D015431:Weight Loss