Analyzing the spindle checkpoint in yeast and frogs.
The spindle checkpoint is an evolutionarily conserved regulatory mechanism that ensures correct segregation of chromosomes at mitosis and meiosis. The kinetochore plays an integral role in spindle checkpoint signaling by integrating chromosome attachment to the spindle with cell cycle progression. A single kinetochore can inhibit cell cycle progression in the absence of proper spindle attachment or tension from bipolar orientation. Recent advances have shed light on how the kinetochore measures these situations, transduces a signal, and inhibits the entry into anaphase.
Stukenberg
P Todd
PT
Department of Biochemistry and Molecular Genetics, University of Virginia Medical Center, Charlottesville, USA.
Burke
Daniel J
DJ
D000705:Anaphase; D000818:Animals; D002453:Cell Cycle; D018386:Kinetochores / Q000648:ultrastructure*; D008938:Mitosis; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D015398:Signal Transduction; D008941:Spindle Apparatus; D014982:Xenopus laevis