[Effect of alahistidine on brain histamine content and seizure development].
To investigate the effect of alahistidine on brain histamine content and seizure development.



The kindling seizure was induced by ip injection with subconvulsant dose of pentylenetetrazole every 48 h. Monoamines and their metabolites were measured using a HPLC system and fluorometric assay.



Chronic low histamine feeding markedly decreased histamine content in cortex and hypothalamus, and promoted seizure development induced by pentylenetetrazole. However, alahistidine feed reversed the decreased histamine content and slowed seizure development caused by low histamine feed. Both low histamine and alahistidine feed had no effect on norepinephrine, dopamine and its metabolites.



Alahistidine may affect histaminergic system and seizure development.
Hu
Wei-wei
WW
Department of Pharmacology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
Chen
Zhong
Z
Xu
Li-sha
LS
Jin
Chun-lei
CL
Sakurai
Eiko
E
Yanai
Kazuhiko
K
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002336:Carnosine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006632:Histamine / Q000032:analysis*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D011969:Receptors, Histamine H1 / Q000502:physiology; D012640:Seizures / Q000139:chemically induced*
D011969:Receptors, Histamine H1; D006632:Histamine; D002336:Carnosine; C015055:carcinine; D010433:Pentylenetetrazole