title: Enyne versus diene RCM in the synthesis of cyclopentene derivatives toward the A ring of FR182877.
abstract: The A ring of FR182877, exemplified by ent-4-b,c, has been synthesized, involving an enyne RCM as the key step. A systematic comparison of enyne vs diene RCM for the formation of cyclopentene derivatives showed that the latter metathesis proceeds much more easily even for this ring size.
authors.affiliation: Laboratoire de Synthèse Organique, UMR CNRS 7652, Ecole Polytechnique, DCSO, F-91128 Palaiseau, France.
authors.forename: Jacques-Alexis
authors.initials: JA
authors.lastname: Funel
authors.forename: Joëlle
authors.initials: J
authors.lastname: Prunet
mesh_terms: D000466:Alkadienes / Q000138:chemical synthesis*; D003517:Cyclopentanes / Q000138:chemical synthesis*; D008968:Molecular Conformation; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000466:Alkadienes; D003517:Cyclopentanes; C408303:FR 182877; D011083:Polycyclic Compounds