title: [Surgical infection in combat injuries of extremities].
abstract: A retrospective analysis was performed of treatment of 1612 patients with gunshot fractures of long bones of the extremities wounded in the Republic of Afghanistan and Chechen Republic. Under study was the infrastructure of the gunshot fractures, general and local factors responsible for the development of suppurations. A angioneurodystrophy theory of pathogenesis of gunshot osteomyelitis is proposed. The level of proinflammatory cytokines was determined in blood serum and wound discharge for the early diagnosis of purulent complications. An algorithm of the diagnostic search was developed with using modern radio- and electrophysiological methods. The standards of general and local treatment are proposed for different stages and spread of the purulent process.
authors.forename: B M
authors.initials: BM
authors.lastname: Shapovalov
authors.forename: A G
authors.initials: AG
authors.lastname: Ovdenko
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001133:Bones of Upper Extremity / Q000293:injuries* / Q000601:surgery; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy; D017707:Erythrocyte Transfusion; D050723:Fractures, Bone / Q000097:blood / Q000150:complications / Q000601:surgery*; D006801:Humans; D007867:Leg Bones / Q000293:injuries* / Q000601:surgery; D010019:Osteomyelitis / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D014857:Warfare; D014948:Wounds, Gunshot / Q000097:blood / Q000150:complications / Q000601:surgery*
chemical_list: D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents