Novel approaches to ocular drug delivery.
Recent advances in surgical techniques, therapeutic approaches and materials sciences have produced revolutionary new therapies for ocular diseases. The development of prodrug formulations and permeability enhancers, sustained-release drug delivery devices, novel injectable medications and new and improved vectors, both viral and non-viral, for delivery of genes to all segments of the eye has greatly increased the chances of success in treating eye diseases. This review will discuss the most recent advances in drug delivery systems for the treatment of ocular diseases.
Davis
Jennifer L
JL
North Carolina State University, Clinical Pharmacology Laboratory, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA. jennifer_davis@ncsu.edu
Gilger
Brian C
BC
Robinson
Michael R
MR
D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use; D004333:Drug Administration Routes; D016503:Drug Delivery Systems; D005123:Eye / Q000033:anatomy & histology; D005128:Eye Diseases / Q000188:drug therapy* / Q000601:surgery; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D011355:Prodrugs / Q000008:administration & dosage / Q000378:metabolism; D019736:Prostheses and Implants
D011355:Prodrugs; D016572:Cyclosporine