CD40: a growing cytoplasmic tale.
CD40, a member of the tumor necrosis factor (TNF) receptor family that is expressed on B cells, monocytes, dendritic cells, endothelial cells, and epithelial cells, as well as on B cell lymphomas and carcinomas, activates multiple signaling pathways. In B cells, the response to CD40 is complex and depends on the maturation status of the cell. It is well established that CD40 can promote cell survival through up-regulation of the expression of genes encoding antiapoptotic proteins. However, a new role for CD40 signaling is being recognized in promoting progression through the cell cycle. The roles of the phosphoinositide 3-kinase, mitogen-activated protein kinase, and nuclear factor kappaB pathways in mediating CD40 stimulation of the cell cycle are described.
Harnett
Margaret M
MM
Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow G11 6NT, UK. m.harnett@bio.gla.ac.uk
D000818:Animals; D019013:CD40 Antigens / Q000502:physiology*; D003593:Cytoplasm / Q000502:physiology*; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000502:physiology*
D019013:CD40 Antigens