The multiparametric scanning system for evaluation of minimal residual disease in hematological malignancies.
Combined simultaneous analysis of morphology, immunophenotyping and fluorescence in situ hybridization on the same cell offers advantages that may help to disclose the relevance of minimal residual disease (MRD) detection. Morphological analysis of small populations of cells related either to malignancy or recipient-associated markers may improve the accuracy of chimerism and MRD testing and delineate their clinical significance.
Trakhtenbrot
Luba
L
Department of Pediatric Hematology-Oncology, Safra Children's Hospital and Institute of Hematology, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. l-tracht@sheba.health.gov.il
Rechavi
Gideon
G
Amariglio
Ninette
N
D048429:Cell Size; D003581:Cytodiagnosis / Q000379:methods*; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D018365:Neoplasm, Residual / Q000175:diagnosis / Q000473:pathology