title: Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats - an effect of tranexamic acid.
abstract: We clarified the role of fibrinolysis in tissue-factor (TF)-induced rat disseminated intravascular coagulation (DIC) using tranexamic acid (TA). TA suppressed the elevation in D-dimer levels normally observed following TF-induced DIC, and an increase in organ dysfunction was seen. Enhanced fibrinolysis plays an important role in preventing the development of organ failure in TF-induced DIC.
authors.forename: Hidesaku
authors.initials: H
authors.lastname: Asakura
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sano
authors.forename: Masahide
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Eriko
authors.initials: E
authors.lastname: Morishita
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Shinji
authors.initials: S
authors.lastname: Nakao
mesh_terms: D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000188:drug therapy*; D005342:Fibrinolysis / Q000502:physiology*; D006487:Hemostasis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013925:Thromboplastin / Q000494:pharmacology*; D014148:Tranexamic Acid / Q000494:pharmacology*
chemical_list: D014148:Tranexamic Acid; D013925:Thromboplastin