Efficacy of ganciclovir and cidofovir against human cytomegalovirus replication in SCID mice implanted with human retinal tissue.
For immunocompromised hosts, human cytomegalovirus (CMV) can be a serious problem. For evaluation of antivirals used to treat CMV retinitis, we have used severe combined immunodeficient mice as hosts for human retinal tissue implanted in the eye and subsequently infected with CMV. Treatment with ganciclovir or cidofovir resulted in a significant suppression of CMV replication.
Bidanset
Deborah J
DJ
Department of Pediatrics, University of Alabama School of Medicine, 128 CHB, 1600 6th Avenue South, Birmingham, AL 35233, USA.
Rybak
Rachel J
RJ
Hartline
Caroll B
CB
Kern
Earl R
ER
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000077404:Cidofovir; D003587:Cytomegalovirus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy; D003596:Cytosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D015774:Ganciclovir / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D014183:Transplantation, Heterologous; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir; D015774:Ganciclovir