The computational integrated myocyte: a view into the virtual heart.
The presentation outlines an integrative approach for developing a computational model of cardiomyocytes. A modular approach is proposed, and strategies of linking the modules (intermediary metabolism, electrophysiology, and mechanics) of the model are presented. A strong recommendation is given toward an integrated system approach backed by experimental validation.
Bassingthwaighte
James B
JB
Department of Bioengineering, University of Washington, Box 357962, Seattle, WA 98195-7962, USA. jbb@bioeng.washington.edu
Vinnakota
Kalyan C
KC
D019295:Computational Biology; D006321:Heart / Q000033:anatomy & histology*; D008954:Models, Biological; D009206:Myocardium / Q000166:cytology*