title: Protein tyrosine phosphatases in the human genome.
abstract: Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.
authors.affiliation: Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Alonso
authors.forename: Joanna
authors.initials: J
authors.lastname: Sasin
authors.forename: Nunzio
authors.initials: N
authors.lastname: Bottini
authors.forename: Ilan
authors.initials: I
authors.lastname: Friedberg
authors.forename: Iddo
authors.initials: I
authors.lastname: Friedberg
authors.forename: Andrei
authors.initials: A
authors.lastname: Osterman
authors.forename: Adam
authors.initials: A
authors.lastname: Godzik
authors.forename: Tony
authors.initials: T
authors.lastname: Hunter
authors.forename: Jack
authors.initials: J
authors.lastname: Dixon
authors.forename: Tomas
authors.initials: T
authors.lastname: Mustelin
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D010766:Phosphorylation; D010802:Phylogeny; D017434:Protein Structure, Tertiary / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000145:classification / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics*; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases