Tolerance to amphetamine hypophagia: a real-time depiction of learning to suppress stereotyped movements in the rat.
To analyze how tolerance develops to amphetamine-induced hypophagia, the authors recorded real-time licking responses in rats given chronic injections of the drug and access to milk for 30 min. Initially, licking was greatly reduced and occurred only late in the session. The acquisition of tolerance was characterized by a decrease in the latency to initiate licking, a gradual increase in the number of licks, and a reorganization of the temporal licking pattern such that licks were distributed throughout the session, interspersed with pauses. On post-tolerance dose-response tests, licking was directly proportional to drug dose in some rats. The results support the view that tolerance to amphetamine hypophagia involves a behavioral adaptation to the motor effects of the drug.
Wolgin
David L
DL
Department of Psychology, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA. wolgindl@fau.edu
Jakubow
James J
JJ
D000662:Amphetamines / Q000009:adverse effects*; D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004327:Drinking Behavior / Q000187:drug effects; D004361:Drug Tolerance; D005247:Feeding Behavior / Q000187:drug effects*; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D000662:Amphetamines; D000697:Central Nervous System Stimulants