Transmissible spongiform encephalopathies in ruminants.
Transmissible spongiform encephalopathies (TSEs) have been observed in North American sheep, cervidae, and cattle. The causative agent of TSEs seems to be proteins that induce a conformational change in normal host proteins. Common clinical signs ofTSEs include chronic weight loss and deteriorating neurologic function. Mechanisms of TSE transmission vary among host species. The diagnostic approach for TSEs of ruminants is presented,and the history and justification of regulatory programs to control and eradicate TSEs are outlined.
Tyler
Jeff W
JW
Department of Veterinary Medicine and Surgery, University of Missouri, 379 East Campus Drive, Columbia, MO 65211, USA. tylerj@missouri.edu
Middleton
John R
JR
D000818:Animals; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis / Q000517:prevention & control; D017096:Prion Diseases / Q000175:diagnosis / Q000517:prevention & control / Q000662:veterinary*; D012418:Ruminants; D012608:Scrapie / Q000175:diagnosis / Q000517:prevention & control; D012756:Sheep; D034081:Wasting Disease, Chronic / Q000175:diagnosis / Q000517:prevention & control