title: Susceptibility of several strains of mice to Echinostoma hortense infection.
abstract: Susceptibilities of 5 different mice strains, including C3H/HeN, BALB/c, C57BL6, FvB and ICR, to Echinostoma hortense infection, was evaluated. The worm expulsion rate, worm size and egg production were observed from 1 to 8 weeks after infection with 30 metacercariae. C3H/HeN and ICR mice showed the highest worm maturation rates. The worm recovery rate and the number of eggs per gram (EPG) of feces was also higher in C3H/HeN and ICR mice than in BALB/c, C57BL6, and FvB mice. It is suggested that E. hortense is highly infectious to ICR and C3H/HeN mice, but not to the other strains of mice. Based on the results obtained, we believe that the susceptibility of different mouse strains to E. hortense infection is dependent on the genetic and immunologic background of mice.
authors.affiliation: Department of Parasitology and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju 220-701, Korea. ryangys@dragon.yonsei.ac.kr
authors.forename: Kyu-Jae
authors.initials: KJ
authors.lastname: Lee
authors.forename: Seung Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Jee Aee
authors.initials: JA
authors.lastname: Im
authors.forename: Soo Kie
authors.initials: SK
authors.lastname: Kim
authors.forename: Geun Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: Gwang Young
authors.initials: GY
authors.lastname: Kim
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Yang
authors.forename: Yong-Suk
authors.initials: YS
authors.lastname: Ryang
mesh_terms: D000818:Animals; D004449:Echinostoma / Q000254:growth & development*; D004451:Echinostomiasis / Q000235:genetics / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D005260:Female; D020022:Genetic Predisposition to Disease; D007422:Intestines / Q000469:parasitology; D051379:Mice / Q000469:parasitology*; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D010270:Parasite Egg Count