Elevated adrenomedullin mRNA in lymphoblastoid cells from schizophrenic patients.
Adrenomedullin (ADM) is a 52 amino acid peptide with multiple physiological functions and wide tissue distributions including brain. Recently, elevated plasma levels of ADM were found in patients with schizophrenia, bipolar affective disorder and autism, suggesting the involvement of ADM in the pathophysiology of mental diseases. Using real-time quantitative PCR, we compared the ADM mRNA levels in lymphoblastoid cell lines between schizophrenic patients and controls. Male but not female schizophrenia patients had 2- to 3-fold higher ADM mRNA levels than controls (p<0.01). Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study.
Huang
Chia-Hsing
CH
Department of Psychiatry, Tzu-Chi General Hospital and Institute of Human Genetics, Tzu-Chi University, Hualien City, 970 Taiwan.
Chen
Mao-Liang
ML
Tsai
Yu-Lin
YL
Tsai
Ming-Ta
MT
Chen
Chia-Hsiang
CH
D053607:Adrenomedullin; D000328:Adult; D002461:Cell Line, Transformed; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology*; D008297:Male; D010455:Peptides / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012559:Schizophrenia / Q000503:physiopathology*; D012727:Sex Characteristics
D010455:Peptides; D012333:RNA, Messenger; D053607:Adrenomedullin