title: Human papillomavirus and squamous cell carcinoma in a solitary tracheal papilloma.
abstract: We report the case of a 52-year-old woman suffering from breathlessness on exertion. A chest radiograph identified a lesion in the intrathoracic trachea. A tumor 0.4 x 0.5 x 0.7 cm in size causing an approximately 80% reduction in the cross-sectional area of the trachea 3 cm above the carina was removed, and histology showed moderately differentiated squamous cell carcinoma. Intrathoracic resection of the tumor and anastomosis was performed through a right lateral thoracotomy. The final histology examination showed atypical papilloma. Polymerase chain reaction-restriction fragment length polymorphism confirmed human papillomavirus-6b in the tumor. The patient remained well 18 months after surgical intervention without recurrence.
authors.affiliation: Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Chung-Wah
authors.initials: CW
authors.lastname: Lam
authors.forename: Alan Ronald
authors.initials: AR
authors.lastname: Talbot
authors.forename: Kun-Tu
authors.initials: KT
authors.lastname: Yeh
authors.forename: Sing-Chun
authors.initials: SC
authors.lastname: Lin
authors.forename: Chia-En
authors.initials: CE
authors.lastname: Hsieh
authors.forename: Hsin-Yuan
authors.initials: HY
authors.lastname: Fang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000601:surgery / Q000821:virology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010212:Papilloma / Q000175:diagnosis / Q000601:surgery / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis*; D014134:Tracheal Neoplasms / Q000175:diagnosis / Q000601:surgery / Q000821:virology*