Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes.
[reaction: see text] A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.
Zhang
Zongren
Z
Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.
Achilefu
Samuel
S
D002232:Carbocyanines / Q000138:chemical synthesis*; D005069:Evaluation Studies as Topic; D005453:Fluorescence; D006900:Hydroxylation; D008968:Molecular Conformation; D015335:Molecular Probes / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D019265:Spectroscopy, Near-Infrared / Q000379:methods
D002232:Carbocyanines; D015335:Molecular Probes