Early events in glutamate receptor trafficking.
Glutamate receptors are the primary mediators of excitatory synaptic transmission in the mammalian central nervous system. Activity-dependent changes in the number of postsynaptic glutamate receptors underlie aspects of synaptic plasticity and provide a mechanism for information storage in the brain. Recent work shows that receptor exit from the endoplasmic reticulum represents a critical regulatory step in glutamate receptor trafficking to the neuronal cell surface.
Vandenberghe
Wim
W
Department of Physiology, University of California at San Francisco, Genentech Hall N274, 600 16(th) Street, San Francisco, CA 94143, USA. wvan8672@itsa.ucsf.edu
Bredt
David S
DS
D000818:Animals; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D017470:Receptors, Glutamate / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology
D017470:Receptors, Glutamate