title: Autonomic nervous system and microvascular alterations in normotensives with a family history of hypertension.
abstract: Autonomic nervous system and microvascular alterations at pre-hypertensive stage of hypertension have still not been fully elucidated. We aimed at addressing central and local influences on microvascular reactivity at pre-hypertensive stage of hypertension. To that end, we studied microvascular reactivity in 59 normotensives with a family history of hypertension and 46 controls. We measured laser-Doppler flow on the finger nailfold skin in the resting condition, after an 8-min occlusion of digital arteries and during local nitroglycerin application. Finger pressure, pulse and ECG were monitored by a Finapres device. Heart rate power spectral analysis was performed using Fast Fourier transformation. Baroreflex sensitivity was estimated by the sequence method. Normotensives with a family history of hypertension showed higher systolic pressure, decreased high-frequency power of the heart rate variability spectrum and reduced baroreflex sensitivity in the resting condition as well as decreased fundamental frequency of laser-Doppler flow oscillations during nitroglycerin application. We conclude that normotensives with a family history of hypertension exhibit altered sympathovagal balance with decreased parasympathetic activity at the cardiac level as well as increased myogenic microvascular reactivity.
authors.affiliation: Institute of Physiology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia. jerica.maver@bass.si
authors.forename: Jerica
authors.initials: J
authors.lastname: Maver
authors.forename: Martin
authors.initials: M
authors.lastname: Strucl
authors.forename: Rok
authors.initials: R
authors.lastname: Accetto
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology*; D017704:Baroreflex; D001783:Blood Flow Velocity; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D014664:Vasodilation