title: Can oral cholera vaccination play a role in controlling a cholera outbreak?
abstract: Control measures to limit the spread of a cholera outbreak in Pohnpei Island (Micronesia), included mass vaccination with the single-dose live-attenuated oral cholera vaccine CVD 103-HgR as a potential adjunct measure. The outbreak provided a unique opportunity to evaluate the practicality of use and effectiveness of this vaccine. Under field conditions encountered in Pohnpei, crude vaccine efficacy was estimated at 79.2% (95% CI: 71.9-84.6%) in the target population. Retrospective analysis suggests that mass vaccination with oral cholera vaccines can be a useful adjunct tool for controlling outbreaks, particularly if implemented early in association with other standard control measures.
authors.affiliation: WHO Western Pacific Regional Office, Manila, Philippines.
authors.forename: Philippe
authors.initials: P
authors.lastname: Calain
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Chaine
authors.forename: Eliaser
authors.initials: E
authors.lastname: Johnson
authors.forename: Mary-Lou
authors.initials: ML
authors.lastname: Hawley
authors.forename: Michael J
authors.initials: MJ
authors.lastname: O'Leary
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Oshitani
authors.forename: Claire-Lise
authors.initials: CL
authors.lastname: Chaignat
mesh_terms: D000284:Administration, Oral; D002771:Cholera / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D022121:Cholera Vaccines / Q000008:administration & dosage* / Q000276:immunology; D004196:Disease Outbreaks / Q000191:economics / Q000517:prevention & control*; D006801:Humans; D014611:Vaccination
chemical_list: D022121:Cholera Vaccines