[The relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma].
OBJECTIVE
To probe the relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma.


METHODS
The microlymphatic vessel density was detected with enzyme histo-chemical method in 47 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa; 355 lymphnodes were detected with immunohistochemically using monoantibody AE3.


RESULTS
The mean MLVD was 14.04 +/- 6.92 in tumor group, or 5.48 +/- 2.62 in normal group. The difference was (P < 0.001). The percentage of tumor with expression CK was 48.9%. The mean MLVD was 16.94 +/- 5.43 in CK positive group, or 11.26 +/- 5.00 in CK negative group, There was difference significant (P < 0.001).


CONCLUSIONS
Lymphangiogenesis plays a key role in cervical lymph node micrometastasis of oral squamous cell carcinoma.
Xie
Zhi-jian
ZJ
Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, College of Medical Science, Zhejiang University, Hangzhou 310006, China. xzj66@zju.edu.cn
Yang
Xiao-feng
XF
Fan
Jun
J
Zhang
Yin-kai
YK
Wu
Qiu-liang
QL
Gu
Zhi-yuan
ZY
D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D009333:Neck