Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients.
A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P < 0.05).
Asrat
Daniel
D
Department of Medical Microbiology, Immunobiology, and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia.
Nilsson
Ingrid
I
Mengistu
Yohannes
Y
Kassa
Endale
E
Ashenafi
Senait
S
Ayenew
Kiros
K
Wadström
Torkel
T
Abu-Al-Soud
Waleed
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D004415:Dyspepsia / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005838:Genotype; D016480:Helicobacter pylori / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori