title: Dietary soy protein attenuates renal disease progression after 1 and 3 weeks in Han:SPRD-cy weanling rats.
abstract: Compared with casein, dietary soy protein slows disease progression in animal models of chronic renal injury. To determine whether dietary soy protein feeding can alter early disease progression, male Han:SPRD-cy rats (n = 87) in a very early stage of chronic kidney disease were fed soy protein compared with casein-based diets for 1 or 3 wk. Kidneys were assessed for fibrosis, cyst growth, fatty acid composition and prostaglandin E(2) (PGE(2)) production. Soy protein feeding significantly reduced renal fibrosis by 22% (P = 0.0347) and 38% (P = 0.0102) after 1 and 3 wk of diet, and cyst growth was 34% lower after 3 wk (P < 0.0001). Kidney 18:2(n-6) levels were reduced in normal and diseased rats after as little as 1 wk of consuming the soy protein diet. Dietary soy protein also partially ameliorated the suppression of PGE(2) production observed in diseased kidneys. Compared with diseased kidneys from casein-fed rats, ex vivo PGE(2) release was 31-32% higher after 1 (P = 0.0281) and 3 (P = 0.0189) wk of dietary soy protein consumption. Hence, the first signs of a beneficial soy protein effect were observed after 1 wk of feeding, with further improvements evident after 3 wk. These data demonstrate that dietary soy protein compared with casein delays disease progression in an early stage of chronic kidney disease.
authors.affiliation: Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada.
authors.forename: Denise E
authors.initials: DE
authors.lastname: Fair
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Ogborn
authors.forename: Hope A
authors.initials: HA
authors.lastname: Weiler
authors.forename: Neda
authors.initials: N
authors.lastname: Bankovic-Calic
authors.forename: Evan P
authors.initials: EP
authors.lastname: Nitschmann
authors.forename: Shirley C
authors.initials: SC
authors.lastname: Fitzpatrick-Wong
authors.forename: Harold M
authors.initials: HM
authors.lastname: Aukema
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002364:Caseins / Q000008:administration & dosage; D003560:Cysts / Q000473:pathology; D004032:Diet; D015232:Dinoprostone / Q000378:metabolism; D018450:Disease Progression; D043371:Fatty Acids, Omega-6 / Q000037:antagonists & inhibitors; D005355:Fibrosis; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D030262:Soybean Proteins / Q000008:administration & dosage*; D013997:Time Factors; D014886:Weaning
chemical_list: D002364:Caseins; D043371:Fatty Acids, Omega-6; D030262:Soybean Proteins; D015232:Dinoprostone