[Pravastatin-associated polymyositis, a case report].
A 69 year old man complained of general myalgia, arthralgia and muscle weakness in two weeks after he started to take 10 mg per day pravastatin. Symptoms progressed at least for 3 months after withdrawal of the medication. The muscle weakness was more in distal upper extremities and the iliopsoas muscle. Serum CK was 943IU/L. The anti-nuclear and Jo-1 antibody were positive. EMG examinations disclosed fibrillation potentials at rest and myopathic discharges by a voluntary contractor. Symptoms as well as serum CK values improved promptly by treatment with prednisolone. From these clinical and laboratory results, it was speculated that this patient suffered from subacute polymyositis, although pathological studies were not performed. Because of continuing hypercholesterolemia, the patient was retreated with atorvastatin, presenting similar, but less serious symptoms. So far, three cases of statin-associated polymyositis or dermatomyositis were reported. Statins could influence the immune system, but it is still unsettled if statins cause autoimmune polymyositis. This problem warrants further study.
Takagi
Akio
A
Department of Neurology, Toranomon Hospital.
Shiio
Yasusi
Y
D000368:Aged; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D017285:Polymyositis / Q000139:chemically induced* / Q000188:drug therapy; D017035:Pravastatin / Q000009:adverse effects*
D000924:Anticholesteremic Agents; D017035:Pravastatin