title: A decline in mupirocin resistance in methicillin-resistant Staphylococcus aureus accompanied administrative control of prescriptions.
abstract: Susceptibility to mupirocin was assessed in methicillin-resistant Staphylococcus aureus isolates selected from eras corresponding to differences in usage rate and prescription policies at a Veterans Affairs medical center. The eras studied encompassed from the time of introduction of the drug to its widespread use, through recommended judicious use, and finally to subsequent stringent administrative control. Prescriptions declined from 3.0 to 0.1 per 1,000 patient days. Precipitous declines first in the numbers of isolates with high-level resistance (from 31% to 4%) and then in those with low-level resistance (from 26% to 10%) accompanied prescription control.
authors.affiliation: James H. Quillen VAMC (11C), Mountain Home, TN 37684, USA. walkeres@etsu.edu
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Walker
authors.forename: Foster
authors.initials: F
authors.lastname: Levy
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Shorman
authors.forename: Gerard
authors.initials: G
authors.lastname: David
authors.forename: Jehad
authors.initials: J
authors.lastname: Abdalla
authors.forename: Felix A
authors.initials: FA
authors.lastname: Sarubbi
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D011307:Drug Prescriptions; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D016106:Methicillin Resistance; D016712:Mupirocin / Q000494:pharmacology*; D009687:Nuclear Proteins / Q000235:genetics; D016133:Polymerase Chain Reaction; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D001426:Bacterial Proteins; D009687:Nuclear Proteins; C480380:mupA protein, Staphylococcus aureus; D016712:Mupirocin