Granulocytic sarcoma: an atypical presentation in the oral cavity.
Acute myelogenous leukemia (AML) is a hematologic disorder that is characterized by an abnormal proliferation of immature myeloid cells. Granulocytic sarcomas are clusters of leukemic myeloid cells that may develop as a result of AML. Oral manifestations of AML are common and often involve enlargements of the gingiva and/or mucosal tissue from direct leukemia cell infiltration. We describe the case history of a 50-year-old man who had an ulcerative lesion of the oral mucosa that was determined to be a granulocytic sarcoma of AML-MO subtype. The combination of both the subtype and clinical presentation of the leukemia makes this presentation unusual, and to the best of our knowledge, of a type that has not been previously reported in the literature.
Stoopler
Eric T
ET
University of Pennsylvania School of Dental Medicine, USA. ets@pobox.upenn.edu
Pinto
Andres
A
Alawi
Faizan
F
Raghavendra
Sree
S
Boyce
Ricardo
R
Porter
David
D
Sollecito
Thomas P
TP
D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D019226:Oral Ulcer / Q000473:pathology*