title: Synthesis and anti-inflammatory effects of novel pimarane diterpenoid analogs.
abstract: Syntheses and excellent anti-inflammatory effects of a series of novel acanthoic acid analogs are reported. In particular, the mechanistic basis for their anti-inflammatory effects is also described.
authors.affiliation: College of Pharmacy, Pharmaceutical Chemistry, Seoul National University, San 56-1 Shinrim-Dong, Kwanak-Gu, Seoul 151-742, South Korea. ygsuh@snu.ac.kr
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Kwang-Ok
authors.initials: KO
authors.lastname: Lee
authors.forename: Sung-Hyun
authors.initials: SH
authors.lastname: Moon
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Seo
authors.forename: Yong-Sil
authors.initials: YS
authors.lastname: Lee
authors.forename: Seok-Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Seung-Mann
authors.initials: SM
authors.lastname: Paek
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Yun-Sang
authors.initials: YS
authors.lastname: Lee
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Jeong
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Sang Geon
authors.initials: SG
authors.lastname: Kim
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D016861:Cyclooxygenase Inhibitors / Q000378:metabolism; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D004487:Edema / Q000378:metabolism; D008956:Models, Chemical; D009569:Nitric Oxide / Q000037:antagonists & inhibitors
chemical_list: D045784:Abietanes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; C099958:acanthoic acid; C433018:pimarane; D009569:Nitric Oxide