Vaccines for the prevention of respiratory viral infections: problems and current status.
Acute respiratory virus infections cause the majority of lower respiratory tract illnesses and hospitalisations of infants and the elderly. The emergence of new respiratory viruses and a high probability that influenza will cause further pandemics highlights the necessity for developing better preventative strategies. Although there is a clear and pressing need for vaccines to prevent respiratory syncytial virus, rhinoviruses, coronaviruses, parainfluenza and human metapneumovirus, progress has been extremely slow. This review presents the current status of vaccine development for respiratory viral diseases and outlines novel approaches for the future.
Olszewska
Wieslawa
W
Department of Respiratory Medicine, Wright Fleming Institute for Infection and Immunity, National Heart and Lung Division, Faculty of Medicine, Imperial College, St. Mary's Campus, Paddington, London W2 1PG, UK. w.olszewska@imperial.ac.uk
Helson
Rebecca
R
Openshaw
Peter J M
PJ
D000257:Adenoviridae Infections / Q000276:immunology / Q000517:prevention & control; D003139:Common Cold / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D029121:Metapneumovirus / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000517:prevention & control; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control; D012141:Respiratory Tract Infections / Q000276:immunology / Q000517:prevention & control*; D045169:Severe Acute Respiratory Syndrome / Q000276:immunology / Q000517:prevention & control; D014765:Viral Vaccines / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control*
D014765:Viral Vaccines