ETV6/RUNX1 rearrangement in childhood B-precursor acute lymphoblastic leukemia with normal karyotypes or without cytogenetic results.
The ETV6/RUNX1 rearrangement (also known as TEL/AML1) was evaluated in 39 children with B-precursor acute lymphoblastic leukemia (ALL) who had a normal karyotype or lack of mitoses. Forty-one point six percent of patients with normal karyotypes and 66.6% of patients without mitoses presented with the ETV6/RUNX1 rearrangement. In addition to this rearrangement, eight patients showed loss of the normal ETV6 allele; of three patients without mitoses, two showed an extra signal of the RUNX1 gene and the third showed the fusion gene duplicated and loss of the normal ETV6 allele. One patient without the ETV6/RUNX1 rearrangement and without mitoses showed two extra signals of the RUNX1 gene.
Alvarez
Y
Y
Departamento de Biología Animal, Biología Vegetal y Ecología, Unidad de Antropología, Facultad de Ciencias, Universidad Autónoma de Barcelona, 08193 Bellaterra (Barcelona), Spain. iolanda.alvarez@uab.es
Gaitán
S
S
Perez
A
A
Bastida
P
P
Ortega
J J
JJ
Dastugue
N
N
Robert
A
A
Aventín
A
A
Badell
I
I
Guitart
M
M
Melo
M
M
Caballín
M R
MR
Coll
M D
MD
D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D050676:Core Binding Factor Alpha 2 Subunit; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D008938:Mitosis; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein