The multiple sclerosis trait: a disease waiting to happen?
There is increasing evidence that the etiology of MS is heterogeneous. MS is often described as a "disease waiting to happen". The pathogenesis of the critical transition to clinical disease according to diagnostic criteria is largely unknown. The role of environment and chance must also be considered. Implications for counselling "at risk" individuals, based on family history, are discussed.
Sadovnick
A D
AD
Department of Medical Genetics and Faculty of Medicine, University of British Columbia, Vancouver Coastal Health Authority-UBC Hospital, G-920, Detwiller Pavilion, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5. sadovnik@infinet.net
D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics; D010375:Pedigree; D012307:Risk Factors