Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population.
OBJECTIVE
The neuropeptide Y (NPY) signal peptide polymorphism T1128C has been linked to several risk factors for cardiovascular disease. The aim of the present study was to evaluate the significance of this polymorphism for cardiovascular and cerebrovascular disease outcome.


METHODS
In a prospective study cohort, 1032 hypertensive patients (174 myocardial infarction and 170 stroke patients and 688 matched controls) were analysed for the T1128C polymorphism in the NPY gene.


METHODS
The dynamic allele specific hybridization (DASH) method was used for genotyping. Serum from the same participants was analysed for total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides.


RESULTS
The frequency of the NPY T1128C polymorphism was 8.4% among patients with a myocardial infarction or stroke, as compared to 5.1% in the control group (P = 0.040). The difference remained significant after adjustment for the cardiovascular risk factors age, sex, smoking status, body mass index, systolic and diastolic blood pressure, presence of diabetes, total cholesterol, HDL, LDL and triglycerides.


CONCLUSIONS
The present study indicates that the NPY T1128C polymorphism is an independent predictor for myocardial infarction and stroke in a Swedish hypertensive population.
Wallerstedt
Susanna M
SM
Department of Clinical Pharmacology, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden. susanna.wallerstedt@pharm.gu.se
Skrtic
Stanko
S
Eriksson
Anna-Lena
AL
Ohlsson
Claes
C
Hedner
Thomas
T
D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D021382:Protein Sorting Signals / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D013548:Sweden / Q000453:epidemiology
D009478:Neuropeptide Y; D021382:Protein Sorting Signals