Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13-25), structurally related to model compound 5 (2-[(4-aminophenyl)-(4-methylsemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester), were synthesized and tested as anticonvulsant agents in DBA/2 mice against sound-induced seizures. The new compounds possess anticonvulsant properties lower than those of prototype 5 but, in some instances, comparable to that of GYKI 52466, a well-known noncompetitive AMPA receptor antagonist.
Micale
Nicola
N
Dipartimento Farmaco-Chimico, Universitá di Messina, Viale Annunziata 98168, Messina, Italy.
De Sarro
Giovambattista
G
Ferreri
Guido
G
Zappalá
Maria
M
Grasso
Silvana
S
Puia
Giulia
G
De Micheli
Carlo
C
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001554:Benzene / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002478:Cells, Cultured; D004149:Dioxoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use*; D015195:Drug Design; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology
D000927:Anticonvulsants; D004149:Dioxoles; D001554:Benzene