title: [The relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To probe the relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma.
  
  
  METHODS
  The microlymphatic vessel density was detected with enzyme histo-chemical method in 47 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa; 355 lymphnodes were detected with immunohistochemically using monoantibody AE3.
  
  
  RESULTS
  The mean MLVD was 14.04 +/- 6.92 in tumor group, or 5.48 +/- 2.62 in normal group. The difference was (P < 0.001). The percentage of tumor with expression CK was 48.9%. The mean MLVD was 16.94 +/- 5.43 in CK positive group, or 11.26 +/- 5.00 in CK negative group, There was difference significant (P < 0.001).
  
  
  CONCLUSIONS
  Lymphangiogenesis plays a key role in cervical lymph node micrometastasis of oral squamous cell carcinoma.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, College of Medical Science, Zhejiang University, Hangzhou 310006, China. xzj66@zju.edu.cn
authors.forename: Zhi-jian
authors.initials: ZJ
authors.lastname: Xie
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Fan
authors.forename: Yin-kai
authors.initials: YK
authors.lastname: Zhang
authors.forename: Qiu-liang
authors.initials: QL
authors.lastname: Wu
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Gu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D042583:Lymphangiogenesis; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D009333:Neck