title: Imaging features of low-grade central osteosarcoma of the long bones and pelvis.
abstract: OBJECTIVE
  To determine the age and gender distribution and imaging features of low-grade central osteosarcoma (LGCOS) of the long bones and pelvis and to discuss our findings in the context of lesions for which LGCOS has been mistaken.
  
  
  METHODS
  We reviewed 99 cases of LGCOS collected between 1919 and 2002 from our institution and pathology consultation files. Adequate imaging was available in 70 cases (36 radiographs only, 17 radiographs/CT, 12 radiographs/MRI, 2 radiographs/CT/MRI, 2 CT only, 1 MRI only, 5 bone scans).
  
  
  RESULTS
  Patient average age was 30.1+/-14.2 years, with a slight female predominance. The femur and tibia were the most common long bones involved (29 and 20 each) with the majority of these tumors arising around the knee, followed by the fibula, radius, humerus and ulna (four, three, two and one case each). Flat bones were involved in six cases (three pelvis, one rib, two scapulae). Short tubular bones were involved in five cases (two metatarsal, two phalanges, one clavicle). The lesion extended to the end of the affected long bone in 22 of 59 cases. Lesions were large at presentation (mean 7.9+/-4.6 cm, range 2-24). Four radiographic patterns were identified: lytic with varying amounts of thick and coarse trabeculation ( n=22), predominantly lytic with few thin, incomplete trabecula ( n=21), densely sclerotic ( n=17) and mixed lytic and sclerotic ( n=10). Lesions were benign-appearing overall with focally aggressive features. CT or MRI demonstrated cortical breech or extension into the soft tissues in all cases.
  
  
  CONCLUSIONS
  LGCOS has a variable appearance on radiographs. A frequent pattern is a slow-growing large intracompartmental fibro-osseous lesion with varying amounts of septal ossification associated with focal areas of aggression. A homogeneously sclerotic pattern was also noted. Imaging with CT or MRI was helpful in every instance in our series in identifying areas of soft tissue extension or cortical disruption suggestive of a low-grade malignancy.
authors.affiliation: Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Kelli J
authors.initials: KJ
authors.lastname: Andresen
authors.forename: Murali
authors.initials: M
authors.lastname: Sundaram
authors.forename: K Krishnan
authors.initials: KK
authors.lastname: Unni
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D000328:Adult; D017677:Age Distribution; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D012516:Osteosarcoma / Q000000981:diagnostic imaging*; D010384:Pelvic Bones / Q000000981:diagnostic imaging*; D011884:Radius / Q000000981:diagnostic imaging; D017678:Sex Distribution; D013977:Tibia / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed