title: An association between central serous chorioretinopathy and gastroesophageal reflux disease.
abstract: OBJECTIVE
  To explore a clinically observed association between central serous chorioretinopathy (CSC) and gastroesophageal reflux disease (GERD) DESIGN: A retrospective case-control study.
  
  
  METHODS
  Sixty-nine consecutive patients diagnosed with CSC were compared with a control group of 55 non-CSC patients.
  
  
  METHODS
  The records of 69 patients with CSC were retrospectively reviewed and compared with the records of 55 controls. All patients and controls were examined in a referral setting.
  
  
  RESULTS
  Patients with CSC were significantly more likely to have GERD compared with controls (odds ratio 6.05; 95% confidence interval 2.14-17.11; P =.0003). Central serous chorioretinopathy patients were also more likely than controls to have used oral corticosteroid medications (odds ratio 16.30; 95% confidence interval 2.09-127.33; P =.0006) and antacid/antireflux medications (odds ratio 15.00; 95% confidence interval 1.91-117.58; P =.001).
  
  
  CONCLUSIONS
  This study identifies an association between CSC and GERD. There are biochemical factors common to both diseases that support this association, giving further insight into the pathogenesis of CSC.
authors.affiliation: University of Alabama at Birmingham, Department of Ophthalmology, USA.
authors.forename: Cheri C
authors.initials: CC
authors.lastname: Mansuetta
authors.forename: John O
authors.initials: JO
authors.lastname: Mason
authors.forename: Jason
authors.initials: J
authors.lastname: Swanner
authors.forename: Richard M
authors.initials: RM
authors.lastname: Feist
authors.forename: Milton F
authors.initials: MF
authors.lastname: White
authors.forename: Martin L
authors.initials: ML
authors.lastname: Thomley
authors.forename: Gerald
authors.initials: G
authors.lastname: McGwin
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Emond
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000863:Antacids / Q000627:therapeutic use; D016022:Case-Control Studies; D015862:Choroid Diseases / Q000150:complications* / Q000503:physiopathology; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D000863:Antacids; D005938:Glucocorticoids