title: Staphylococcal resistance and oral cephalosporins for skin and skin structure infections.
abstract: The common classification of cephalosporins into "generations," based on their activity toward gram-positive and gram-negative organisms, does not adequately reflect the differences among these drugs, especially for newer, broad-spectrum antibiotics. Thus, clinicians need to understand the complete spectrums of activity for these drugs to treat patients effectively and minimize the development of drug resistance.
authors.affiliation: Veterans Affairs Medical Center, Coatesville, Pennsylvania, USA.
authors.forename: Warren S
authors.initials: WS
authors.lastname: Joseph
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D018461:Soft Tissue Infections / Q000188:drug therapy*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*; D013290:Streptococcal Infections / Q000188:drug therapy; D013297:Streptococcus pyogenes
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins