title: Role of noncovalent interactions in the enantioselective reduction of aromatic ketimines with trichlorosilane.
abstract: [reaction: see text] Asymmetric reduction of ketimines 1 with trichlorosilane can be catalyzed by a new N-methyl L-valine derived Lewis basic organocatalyst, such as 4d, with high enantioselectivity. The structure-reactivity investigation suggests hydrogen bonding and arene-arene interactions between the catalyst and the incoming imine as the main factor determining the enantiofacial selectivity.
authors.affiliation: Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K. amalkov@chem.gla.ac.uk
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: Andrea
authors.initials: A
authors.lastname: Mariani
authors.forename: Kenneth N
authors.initials: KN
authors.lastname: MacDougall
authors.forename: Pavel
authors.initials: P
authors.lastname: Kocovský