title: Systemic lupus erythematosus presenting as amyotrophic lateral sclerosis.
abstract: We report a case of a 27-year-old Omani lady having a 3-year history of progressive skeletal muscle weakness with clinical and skeletal muscle changes of ALS, who during the course of investigations for ALS was found to have SLE. This association is not a simple coincidence but perhaps a causal relationship, opening vistas to explain the autoimmune pathogenesis and justification for immunosuppressive therapy in ALS. SLE presenting as ALS has not been reported earlier.
authors.affiliation: Department of Pathology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman. rao526@squ.edu.om
authors.forename: T V
authors.initials: TV
authors.lastname: Rao
authors.forename: J K J
authors.initials: JK
authors.lastname: Tharakan
authors.forename: P C
authors.initials: PC
authors.lastname: Jacob
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D001323:Autoantibodies / Q000276:immunology; D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D042783:Endothelial Cells / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology*; D008854:Microscopy, Electron; D018908:Muscle Weakness / Q000276:immunology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D009133:Muscular Atrophy / Q000276:immunology / Q000503:physiopathology; D011782:Quadriplegia / Q000276:immunology / Q000503:physiopathology
chemical_list: D001323:Autoantibodies