Growth hormone deficiency and related disorders: insights into causation, diagnosis, and treatment.
Advances in molecular biology have led to the identification of mutations within several novel genes associated with the phenotype of isolated growth hormone deficiency, combined pituitary hormone deficiency, and syndromes such as septo-optic dysplasia. Progress has also been made in terms of the optimum diagnosis of disorders of stature and their treatment. The use of growth hormone for the treatment of adults with growth hormone deficiency and conditions such as Turner's syndrome, Prader-Willi syndrome, intrauterine growth restriction, and chronic renal failure has changed the practice of endocrinology, although cost-benefit implications remain to be established.
Dattani
Mehul
M
Institute of Child Health, University College London, London WC1N 1EH, UK.
Preece
Michael
M
D000818:Animals; D001827:Body Height; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006128:Growth / Q000235:genetics / Q000502:physiology; D006130:Growth Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D013006:Growth Hormone / Q000172:deficiency* / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D009154:Mutation; D010903:Pituitary Gland, Anterior / Q000196:embryology / Q000502:physiology; D010907:Pituitary Hormones / Q000172:deficiency
D010907:Pituitary Hormones; D007987:Gonadotropin-Releasing Hormone; D013006:Growth Hormone