title: [Effect of specific immunoglobulin Y in the treatment of acute and chronic pharyngitis].
abstract: OBJECTIVE
  To evaluate the effect and safety of the specific immunoglobulin Y (IgY) for treatment of acute and chronic pharyngitis.
  
  
  METHODS
  Double-blind, randomized, placebo-controlled trial was conducted on 50 adults with acute pharyngitis. Experimental group received a 6 times-daily total 30 doses of IgY stomat-spray which contained specific immunoglobulin Y (titer = 512) prepared from the egg yolk of hens immunized with a variety of bacteria. Another open label trial included 50 patients, whose ages ranged from 21-69 years, including 25 cases of acute pharyngitis and 25 cases of chronic pharyngitis were also treated using IgY stomat-spray. The therapeutic effect were objectively evaluated 7 days later by the decreased scores based on both the symptoms and physical signs. If the symptom did not improve or became severe three days later, these patients with acute pharyngitis was inefficiency and antibiotic medicine would be added to them.
  
  
  RESULTS
  In Double-blind trial, 8 cases (32%) received IgY had apparent effect with the decreased scores 5 or more than 5, 13 cases (52%) had effective with the decreased scores 3-4, and other 4 cases (16%) had inefficacy with the decreased scores only 2 or no more than 2. While in placebo-controlled group, only 2 (8%) cases had apparent effect, 5 (20%) cases showed effective and 18 (72%) cases had non-effect. The difference between the two groups was significant (chi 2 = 16.06, P < 0.01). In open label trial, 19 cases (38%) showed apparent effect, in which 14 cases were acute pharygitis. 23 cases (46%) had effective, in which 10 cases were acute pharyngitis. The left 8 cases (16%) had ineffective, in which one case was acute pharyngitis. There was significantly difference (chi 2 = 8.90, P < 0.05) between acute pharyngitis and chronic pharyngitis. An average of three months followup showed that there were no side effect or toxic effect and no allergic reaction.
  
  
  CONCLUSIONS
  The IgY stomat-spray is a safe and effective agent in treating acute and chronic pharyngitis, especially for acute pharyngitis.
authors.affiliation: Department of Otorhinolaryngology, Third Affiliated Hospital, Sun Yet Sen University, Guangzhou 510630, China. min_qiang_x@hotmail.com
authors.forename: Min-qiang
authors.initials: MQ
authors.lastname: Xie
authors.forename: Yong-xiang
authors.initials: YX
authors.lastname: Meng
authors.forename: Zhong-han
authors.initials: ZH
authors.lastname: Li
authors.forename: Yong-qi
authors.initials: YQ
authors.lastname: Li
authors.forename: Kou-xing
authors.initials: KX
authors.lastname: Zhang
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Zhao
authors.forename: Guo-jun
authors.initials: GJ
authors.lastname: Xiong
authors.forename: Yong-ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000208:Acute Disease; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010612:Pharyngitis / Q000628:therapy*; D013292:Streptococcus agalactiae / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: C016512:IgY; D007136:Immunoglobulins