Endothelial cell-cell adhesion and mechanosignal transduction.
Recent reports indicate that in addition to proteins that form various types of intercellular junctions, a considerable number of proteins are localized to the area of endothelial cell-cell association. Many of these are signaling proteins, suggesting that this is an area of active signaling. In this article, we have attempted to compile a list of proteins that have been localized to the area of interendothelial association and to briefly discuss what is known about each. Since various investigators including ourselves have proposed that the region of interendothelial cell association is an important site for mechanosignaling, we will focus our discussion on the possible role of these proteins in mechanosignal transduction. We will also review the available evidence for PECAM-1 as a mechanotransducing molecule in endothelial cells.
Chiu
Yi-Jen
YJ
Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA. Keigi_Fujiwara@urmc.rochester.edu
Kusano
Ken-ichi
K
Thomas
Tamlyn N
TN
Fujiwara
Keigi
K
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism* / Q000648:ultrastructure; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D013314:Stress, Mechanical
D008565:Membrane Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1