title: Efficacy of substituting innovator propafenone for its generic formulation in patients with atrial fibrillation.
abstract: The clinical outcomes of 114 patients with atrial fibrillation who had been treated with the innovator propafenone, and in whom the drug was then replaced with generic propafenone because of cost containment, were compared. The generic formulation was found to be at least as safe and effective as the innovator drug, with regard to atrial fibrillation recurrence, emergency room and hospital admissions, and necessity for concomitant therapy.
authors.affiliation: Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University, Beer Sheva, Israel.
authors.forename: Guy
authors.initials: G
authors.lastname: Amit
authors.forename: Amit
authors.initials: A
authors.lastname: Rosen
authors.forename: Avraham B
authors.initials: AB
authors.lastname: Wagshal
authors.forename: Dan Y
authors.initials: DY
authors.lastname: Bonneh
authors.forename: Tzvika
authors.initials: T
authors.lastname: Liss
authors.forename: Aviva
authors.initials: A
authors.lastname: Grosbard
authors.forename: Reuven
authors.initials: R
authors.lastname: Ilia
authors.forename: Amos
authors.initials: A
authors.lastname: Katz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy*; D015331:Cohort Studies; D016568:Drugs, Generic / Q000627:therapeutic use*; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D010343:Patient Admission / Q000706:statistics & numerical data; D011405:Propafenone / Q000627:therapeutic use*; D012008:Recurrence; D012189:Retrospective Studies; D013810:Therapeutic Equivalency; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D016568:Drugs, Generic; D011405:Propafenone