The effect of different nutritional feeds on the postprandial glucose response in healthy volunteers and patients with type II diabetes.
OBJECTIVE
Assessment of postprandial glycaemic response to four nutritional feeds with different macronutrient and fibre composition.


METHODS
A randomized, double-blind, crossover study.


METHODS
University of Maastricht, the Netherlands.


METHODS
A total of 10 healthy volunteers and 10 patients with type II diabetes.


METHODS
Subjects received 200 kcal of four enteral nutrition products (two standard products and two diabetes-specific products). Fasting and postprandial plasma glucose were measured for 2 h. Peak glucose level and area under the curve were calculated.


RESULTS
In healthy volunteers and diabetic patients, the feed with a low carbohydrate (CHO), high monounsaturated fatty acid (MUFA) and high fibre content significantly decreased peak glucose concentration and area under the curve compared to the feeds with standard composition.


CONCLUSIONS
Special feeds with a low CHO, high MUFA and high fibre content improve glycaemic balance and therefore should be considered in diabetic patients who are in need of nutritional support.
Hofman
Z
Z
Numico Research BV, Wageningen, The Netherlands. zandrie.hofman@numico-research.nl
van Drunen
J D E
JD
de Later
C
C
Kuipers
H
H
D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000628:therapy; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000378:metabolism; D004043:Dietary Fiber / Q000008:administration & dosage* / Q000378:metabolism; D004311:Double-Blind Method; D004750:Enteral Nutrition / Q000592:standards; D005260:Female; D038321:Glycemic Index; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D004043:Dietary Fiber