Upper aerodigestive tract complications in a neonate with linear IgA bullous dermatosis.
Linear IgA bullous dermatosis (LABD) is a rare immunobullous condition known to affect the skin and mucous membranes of the eye and oral cavity in adults and young children. We describe a newborn with skin involvement who had life-threatening respiratory compromise from disease affecting the larynx, subglottis, trachea, and esophagus. Management with both tracheostomy and gastrostomy tube placement was necessary. Treatment included systemic steroids, dapsone, and intravenous immunoglobulin. We compare our neonatal case to the only other report in the literature highlighting involvement of the mucous membranes of multiple levels of the aerodigestive tract leading to respiratory compromise.
Gluth
Michael B
MB
Division of Pediatric Otolaryngology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Witman
Patricia M
PM
Thompson
Dana M
DM
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002404:Catheterization; D003131:Combined Modality Therapy; D003622:Dapsone / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004935:Esophageal Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D004945:Esophagoscopy / Q000379:methods; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D007818:Laryngeal Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D012131:Respiratory Insufficiency / Q000209:etiology / Q000601:surgery; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000276:immunology*; D014133:Tracheal Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy
D000893:Anti-Inflammatory Agents; D007070:Immunoglobulin A; D016756:Immunoglobulins, Intravenous; D003907:Dexamethasone; D003622:Dapsone