Delayed central nervous system superficial siderosis following brachial plexus avulsion injury. Report of three cases.
Chronic subarachnoid hemorrhage may cause deposition of hemosiderin on the leptomeninges and subpial layers of the neuraxis, leading to superficial siderosis (SS). The symptoms and signs of SS are progressive and fatal. Exploration of potential sites responsible for intrathecal bleeding and subsequent hemosiderin deposition may prevent disease progression. A source of hemorrhage including dural pathological entities, tumors, and vascular lesions has been previously identified in as many as 50% of patients with SS. In this report, the authors present three patients in whom central nervous system SS developed decades after brachial plexus avulsion injury. They believe that the traumatic dural diverticula in these cases may be a potential source of bleeding. A better understanding of the pathophysiology of SS is important to develop more suitable therapies.
Cohen-Gadol
Aaron A
AA
Department of Neurologic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA. cohengadol.aaron@mayo.edu
Krauss
William E
WE
Spinner
Robert J
RJ
D000328:Adult; D000368:Aged; D001917:Brachial Plexus / Q000293:injuries*; D002574:Cervical Vertebrae / Q000293:injuries*; D018450:Disease Progression; D004388:Dura Mater / Q000098:blood supply* / Q000601:surgery; D005242:Fecal Incontinence / Q000209:etiology; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D006801:Humans; D007796:Laminectomy; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D019838:Neck Injuries / Q000150:complications*; D009759:Nystagmus, Pathologic / Q000209:etiology; D020335:Paraparesis / Q000209:etiology; D011843:Radiculopathy / Q000150:complications* / Q000601:surgery; D012806:Siderosis / Q000209:etiology*; D013345:Subarachnoid Hemorrhage / Q000150:complications* / Q000601:surgery; D013346:Subarachnoid Space; D013997:Time Factors; D014549:Urinary Incontinence / Q000209:etiology