title: [Indurated erythema as the presenting form of a case of chronic myelomonocytic leukemia].
abstract: Chronic myelomonocytic leukemia (CMML) is an oncohematologic disease with a mixed nature, myeloproliferative and myelodysplastic, and presenting features are usually the consequence of peripheral blood cytopenias (anemic syndrome, infections or bleeding). Specific or non-specific cutaneous involvement in patients with myelodysplastic syndromes or chronic leukemias is exceptional, and it takes place often in advanced stages of the disease, as a preample of a transformation from chronic illness to acute leukemia. Recognition and early diagnosis of the skin lesion by cutaneous biopsy, in every patient with myelodysplastic or myeloproliferative disease, have therapeutic and prognostic significance. We describe a patient who presented with a non-especific cutaneous lesion, Bazin's erhythema induratum, as initial manifestation of chronic myelomonocytic leukemia; we also comment diagnostic, therapeutic and clinical evolution aspects.
authors.affiliation: Servicio de Hematología, Hospital Universitario de Canarias, La Laguna, Tenerife. jomaraya@yahoo.es
authors.forename: J M
authors.initials: JM
authors.lastname: Raya Sánchez
authors.forename: M J
authors.initials: MJ
authors.lastname: Rodríguez Salazar
authors.forename: M L
authors.initials: ML
authors.lastname: Brito Barroso
authors.forename: F
authors.initials: F
authors.lastname: Guimerá Martín-Neda
authors.forename: H
authors.initials: H
authors.lastname: Alvarez-Argüelles Cabrera
authors.forename: L
authors.initials: L
authors.lastname: Hernández Nieto
mesh_terms: D001706:Biopsy; D003937:Diagnosis, Differential; D004891:Erythema Induratum / Q000209:etiology* / Q000473:pathology; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014382:Tuberculosis, Cutaneous / Q000175:diagnosis