Double allogeneic peripheral blood stem cell transplantation in a 9-year-old patient with relapsed acute lymphoblastic leukemia: case report.
A 9-year-old female patient with relapsed leukemia that was refractory to conventional reinduction chemotherapy was successfully treated with double allogeneic peripheral blood stem cell transplantation. The conditioning regimen for the first transplantation consisted of busulfan, etoposide, and melphalan, and that for the second transplantation was total body irradiation and thiotepa. Neither severe regimen-related toxicity nor graft-versus-host disease was observed. The patient is in complete remission without major complications for 5 years. Double transplantation should be considered as one of the possible treatments for refractory acute lymphoblastic leukemia.
Fujii
Hisaki
H
Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. hfujii@med.yokohama-cu.ac.jp
Goto
Hiroaki
H
Watanabe
Yuka
Y
Yamazaki
Sakurako
S
Takahashi
Hiroyuki
H
Sekiguchi
Haruyuki
H
Funabiki
Tetsunori
T
Ikuta
Koichiro
K
Yokota
Shunpei
S
D002648:Child; D018572:Disease-Free Survival; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy / Q000379:methods*; D013852:Thiotepa / Q000627:therapeutic use; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D017211:Treatment Failure; D014916:Whole-Body Irradiation
D013852:Thiotepa