Langerhans' cell histiocytosis: current trends and the role of the head and neck surgeon.
Langerhans' cell histiocytosis (LCH)--once called histiocytosis X--is a complex reticuloendothelial disease that often involves the head and neck. We discuss the current nomenclature of this disease and review its pathologic and clinical characteristics, with particular emphasis on the role of the head and neck surgeon. LCH can be challenging to diagnose, and the otolaryngologist must be familiar with its varied presentations. Because LCH usually responds well to medical therapy and extensive resection can easily cause more morbidity than the disease itself, a minimalist approach to treatment usually provides the best outcome. We also discuss the case of a 9-month-old girl with LCH who presented with aggressive head and neck disease.
Davis
Steven E
SE
Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1200 N. State St., Los Angeles, CA 90033, USA.
Rice
Dale H
DH
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006646:Histiocytosis, Langerhans-Cell / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007223:Infant; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000473:pathology; D009059:Mouth Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D009355:Neomycin / Q000627:therapeutic use; D010036:Otolaryngology / Q000639:trends*; D021362:Palate, Hard / Q000000981:diagnostic imaging / Q000473:pathology; D011112:Polymyxin B / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D011239:Prednisolone; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone