title: Post-surgical scleritis associated with the ganciclovir implant.
abstract: Although the ganciclovir implant is an effective and well-tolerated treatment for cytomegalovirus retinitis in patients with human immunodeficiency virus infection, complications that may occur include retinal detachment, implant extrusion, and endophthalmitis. A 22-year-old woman with human immunodeficiency virus infection presented with a painful left eye with scleritis overlying previous ganciclovir implant sclerotomy sites. The inflammation progressed 360 degrees around the pars plana with progressive thinning at the implant sites. Post-surgical necrotizing scleritis is another complication that can occur in patients with ganciclovir implants.
authors.affiliation: National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1863, USA.
authors.forename: Sunil
authors.initials: S
authors.lastname: Srivastava
authors.forename: Perdita
authors.initials: P
authors.lastname: Taylor
authors.forename: Lauren V
authors.initials: LV
authors.lastname: Wood
authors.forename: Susan S
authors.initials: SS
authors.lastname: Lee
authors.forename: Michael R
authors.initials: MR
authors.lastname: Robinson
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy; D004343:Drug Implants / Q000009:adverse effects*; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage*; D006801:Humans; D011183:Postoperative Complications; D015423:Scleritis / Q000209:etiology*
chemical_list: D000998:Antiviral Agents; D004343:Drug Implants; D015774:Ganciclovir