Synthesis and biological evaluation of new thiazolopyrimidines.
In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones (1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-methylthiazolo[5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones (4-6, 10) and 3-benzyl-5-methyl thiazolo[5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones (7a-b) were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising antimicrobial activity and non of them showed any appreciable antitumor activity.
Said
Makarem
M
Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Egypt.
Abouzid
Khaled
K
Mouneer
Ashraf
A
Ahmedy
Ali
A
Osman
Abdel Moneim
AM
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000627:therapeutic use; D013844:Thiazoles / Q000138:chemical synthesis* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011743:Pyrimidines; D013844:Thiazoles