title: Stiff person syndrome does not always occur with maternal passive transfer of GAD65 antibodies.
abstract: The authors report the presence of high titer antibodies to glutamic acid decarboxylase (anti-GAD65) until age 24 months in two asymptomatic newborns of a woman with stiff-person syndrome (SPS). No signs of SPS were detectable in the two children at ages 6 and 8 years. This observation indicates that other cofactors are involved in the pathogenesis of SPS.
authors.affiliation: Department of Neurological Rehabilitation, Don C. Gnocchi Foundation, University of Milan, Italy. raffaello.nemni@unimi.it
authors.forename: R
authors.initials: R
authors.lastname: Nemni
authors.forename: L M
authors.initials: LM
authors.lastname: Caniatti
authors.forename: M
authors.initials: M
authors.lastname: Gironi
authors.forename: E
authors.initials: E
authors.lastname: Bazzigaluppi
authors.forename: D
authors.initials: D
authors.lastname: De Grandis
mesh_terms: D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D007527:Isoenzymes / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D016750:Stiff-Person Syndrome / Q000276:immunology*; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007518:Isoantibodies; D007527:Isoenzymes; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2