Enyne versus diene RCM in the synthesis of cyclopentene derivatives toward the A ring of FR182877.
The A ring of FR182877, exemplified by ent-4-b,c, has been synthesized, involving an enyne RCM as the key step. A systematic comparison of enyne vs diene RCM for the formation of cyclopentene derivatives showed that the latter metathesis proceeds much more easily even for this ring size.
Funel
Jacques-Alexis
JA
Laboratoire de Synthèse Organique, UMR CNRS 7652, Ecole Polytechnique, DCSO, F-91128 Palaiseau, France.
Prunet
Joëlle
J
D000466:Alkadienes / Q000138:chemical synthesis*; D003517:Cyclopentanes / Q000138:chemical synthesis*; D008968:Molecular Conformation; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D000466:Alkadienes; D003517:Cyclopentanes; C408303:FR 182877; D011083:Polycyclic Compounds