title: [Sterilizing effect of the mutant allele sbr10 (l(1)ts403) in compound with null alleles in Drosophila melanogaster females].
abstract: In females of Df(1)v-L4/+(0/+) genotype, the presence of the wild-type allele of small bristles (sbr) gene in a single dose has no significant effect on their fecundity, whereas a reduced dose of the temperature-sensitive allele sbr10(l(1)ts403) causes a strong sterilizing effect in females Df(1)v-L4/sbr10 (0/sbr10) at permissive temperature. We studied the contribution to this effects of the following factors: resorption of egg chambers, decreased oviposition, offspring death at the embryonic and larval stages, and reduced fecundity in females 0/sbr10. Sterilizing effect of the mutant sbr10 allele proved to be primarily caused by offspring lethality at the embryonic and first-instar larval stages. In 0/+ females, the majority of undeveloped eggs contained embryos that perished at the late developmental stages, whereas in females 0/sbr10, at least 50% of undeveloped egg showed no visible signs of development or the embryo development was arrested at early stages of embryogenesis. The results obtained suggest insufficiency of the temperature-sensitive allele sbr10 in haploid state to ensure the reproductive functions of Drosophila melanogaster females.
authors.affiliation: Department of Genetics and Breeding, St. Petersburg State University, St. Petersburg, 199034 Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Golubkova
authors.forename: O M
authors.initials: OM
authors.lastname: Pugacheva
authors.forename: E P
authors.initials: EP
authors.lastname: Demina
authors.forename: A S
authors.initials: AS
authors.lastname: Musorina
authors.forename: A N
authors.initials: AN
authors.lastname: Shershabova
authors.forename: L A
authors.initials: LA
authors.lastname: Mamon
mesh_terms: D000483:Alleles; D000818:Animals; D004331:Drosophila melanogaster; D005260:Female; D007247:Infertility, Female / Q000235:genetics*; D009154:Mutation