title: Nitrous oxide impairs selective stages of working memory in rats.
abstract: Working memory impairment under narcosis has never been investigated. Furthermore, mechanisms by which narcosis disturbs working memory processes remain relatively unknown. The present work was aimed at answering to these two questions using a well-known normobaric narcotic gas, nitrous oxide (N2O), and a classical working memory task (a two-trial recognition memory task). Ten Long-Evans rats were tested in this behavioral task under nitrous oxide exposure. The results showed (i) a dose-related impairment of working memory, (ii) a selective effect of N2O on two out of three mnemonic processes: acquisition, and retention, and (iii) a compensatory effect of increasing the acquisition phase duration on these impairments. These results, as previously suggested for long-term memory, agree with the fact that nitrous oxide disrupts in a dose-related manner working memory by notably slowing down acquisition processes.
authors.affiliation: Laboratoire de Physiopathologie du comportement, INSERM Unité 588, Institut François Magendie, 1 rue Camille Saint Saëns, 33077 Bordeaux Cedex, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Rabat
authors.forename: Jeannine
authors.initials: J
authors.lastname: Hardouin
authors.forename: Alain
authors.initials: A
authors.lastname: Courtière
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced / Q000503:physiopathology*; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D009609:Nitrous Oxide / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans; D012153:Retention, Psychology / Q000187:drug effects; D013997:Time Factors
chemical_list: D018712:Analgesics, Non-Narcotic; D009609:Nitrous Oxide