Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS.
Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses, and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.
Ansari
Aftab A
AA
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA. pathaaa@emory.edu
Mayne
Ann E
AE
Onlamoon
Nattawat
N
Pattanapanyasat
Kovit
K
Mori
Kazuyasu
K
Villinger
Francois
F
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000235:genetics / Q000627:therapeutic use*; D000818:Animals; D016207:Cytokines / Q000235:genetics* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D018664:Interleukin-12 / Q000235:genetics / Q000276:immunology; D019409:Interleukin-15 / Q000235:genetics / Q000276:immunology; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D008253:Macaca mulatta; D011994:Recombinant Proteins / Q000235:genetics / Q000627:therapeutic use; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D019409:Interleukin-15; D007376:Interleukin-2; D011994:Recombinant Proteins; D018664:Interleukin-12; D007371:Interferon-gamma