Survival and migration of transplanted neural stem cell-derived dopamine cells in the brain of parkinsonian rat.
Dopamine cells derived from neural stem cells were transplanted into the dopamine-denervated striatum in the rat. Survival of the dopamine cells, gliosis, and immunological reaction were examined by immunostaining. Tyrosine hydroxylase immunoreactive (TH+) cells were seen in the needle tract, walls of the lateral ventricle, thalamus, hippocampus, and external and internal capsules for up to 3 weeks examination. Most TH+ cells had mature-looking polygonal shapes with processes. Some cells migrated into the striatum. Behavioral improvement was not seen
Ahn
Tae-Beom
TB
Department of Neurology, Seoul National University College of Medicine, and Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
Kim
Jong-Min
JM
Kwon
Kyung-Mi
KM
Lee
Sang-Hun
SH
Jeon
Beom S
BS
D018663:Adrenergic Agents / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D004622:Embryo, Mammalian; D005346:Fibroblast Growth Factors / Q000502:physiology; D007150:Immunohistochemistry / Q000379:methods; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D064231:Nestin; D009474:Neurons / Q000378:metabolism / Q000637:transplantation*; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D033581:Stem Cell Transplantation / Q000379:methods; D013234:Stem Cells / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D018663:Adrenergic Agents; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577486:Nes protein, rat; D064231:Nestin; D005346:Fibroblast Growth Factors; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine