Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events.
Emotional events are remembered better than neutral events possibly because the amygdala enhances the function of medial temporal lobe (MTL) memory system (modulation hypothesis). Although this hypothesis has been supported by much animal research, evidence from humans has been scarce and indirect. We investigated this issue using event-related fMRI during encoding of emotional and neutral pictures. Memory performance after scanning showed a retention advantage for emotional pictures. Successful encoding activity in the amygdala and MTL memory structures was greater and more strongly correlated for emotional than for neutral pictures. Moreover, a double dissociation was found along the longitudinal axis of the MTL memory system: activity in anterior regions predicted memory for emotional items, whereas activity in posterior regions predicted memory for neutral items. These results provide direct evidence for the modulation hypothesis in humans and reveal a functional specialization within the MTL regarding the effects of emotion on memory formation.
Dolcos
Florin
F
Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA. fdolcos@duke.edu
LaBar
Kevin S
KS
Cabeza
Roberto
R
D000328:Adult; D000679:Amygdala / Q000502:physiology*; D000704:Analysis of Variance; D001931:Brain Mapping; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*