title: Fractionation of radiation treatment in acoustics. Rationale and evidence in comparison to radiosurgery.
abstract: Stereotactic fractionated radiotherapy has been proposed as a strategy to improve upon the results of single-fraction radiosurgery. The rationale for the strategy is that fractionation will allow complciations to be reduced while maintaining the same degree of long-term tumor control. This paper reviews the radiobiological arguements for fractionating radiation treatment of acoustic neuromas and examines claims for improvement in outcome.
authors.affiliation: Department of Radiation Oncology, The Center for Image-Guided Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, PA 15213, USA. flickingerjc@msx.upmc.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Flickinger
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
authors.forename: L
authors.initials: L
authors.lastname: Lunsford
mesh_terms: D019583:Dose Fractionation, Radiation; D004428:Ear Neoplasms / Q000601:surgery*; D006801:Humans; D009464:Neuroma, Acoustic / Q000601:surgery*; D016634:Radiosurgery / Q000145:classification* / Q000295:instrumentation*