title: [A case-control study on the risk of female breast cancer in Wuhan area].
abstract: OBJECTIVE
  To investigate the risk factors of female breast cancer and its potential alteration in Wuhan area.
  
  
  METHODS
  A case-control study was conducted on 213 cases with histopathological diagnosis and 430 matched controls, using conditional logistic regression analysis.
  
  
  RESULTS
  28 factors such as educational level, history of benign breast disease, age at menarche, age at menopausal, meat and well-done meat intake, soy bean food, fruit, lactation time, body mass index (BMI), juvenile chest X-ray, psychological factor, were associated with breast cancer risk in one-way variance model. Multivariate conditional logistic regression analysis in total significant factors and subgroups showed that the risk factors of breast cancer would include high level education, psychological trauma, history of benign breast disease later age at menopause, more years of menstrual and more years of menstrual before giving first birth, high BMI, well-done meat intake and smoked food. Factors as later menarche, lactate longer, soybean food, fruit, drink tea habit were protective factors for breast cancer. Further breakdown of data showed some difference between premenopausal and postmenopausal women. Risks in premenopausal women were associated with history of benign breast disease, age of menarche, soybean food intake, whereas risks in postmenopausal women were related to age of menopausal, BMI, waist-hip ratio and fruit intake. Both psychological traumatic and duration of lactation were common pre-and postmenopausal risk and protective factors.
  
  
  CONCLUSIONS
  Dietary habit and endogenous estrogen exposure related factors played important roles on women breast cancer in Wuhan area.
authors.affiliation: The Zhongnan Hospital, Public Health Department of Wuhan University, Wuhan 430071, China.
authors.forename: Ding-fen
authors.initials: DF
authors.lastname: Han
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Qiu
authors.forename: Li
authors.initials: L
authors.lastname: Fang
authors.forename: Shu
authors.initials: S
authors.lastname: Huang
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000209:etiology* / Q000378:metabolism; D016022:Case-Control Studies; D002681:China; D045166:Estradiol Congeners / Q000378:metabolism; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors
chemical_list: D045166:Estradiol Congeners