title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and long term immunologic memory.
abstract: The highlighted article by B. Paige Lawrence and Beth Vorderstrasse addresses an oft forgotten aspect of immunotoxicity, the effects of environmental toxins on immunologic memory. Here, the authors take a step towards filling that information gap by evaluating the effects of a prototypic environmental toxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), on memory responses to a real-world pathogen, influenza A virus, presented to an animal model in a physiologically relevant manner. Multiple outcomes are evaluated, the vast majority of which suggest important and long-term TCDD-induced changes in the immune system after both primary and secondary exposure to this pathogen. The implications of these studies with regard to the immuno-competence of TCDD-exposed individuals are far reaching.
authors.affiliation: Department of Environmental Health, Boston University School of Public Health, 715 Albany Street (R-408), Boston, Massachusetts 02118, USA. dsherr@bu.edu
authors.forename: David H
authors.initials: DH
authors.lastname: Sherr
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D004785:Environmental Pollutants / Q000633:toxicity*; D007156:Immunologic Memory / Q000187:drug effects*; D009980:Influenza A virus / Q000276:immunology* / Q000472:pathogenicity; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*
chemical_list: D000914:Antibodies, Viral; D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins