Deletion of multimerin-1 in alpha-synuclein-deficient mice.
A deletion of the murine Snca gene has been discovered in C57BL/6JOlaHsd, a population of the inbred strain C57BL/6J. We now characterize the exact nature of this deletion, Del(6)Snca1Slab. Detailed mapping and sequencing of the breakpoint revealed the absence of 365 kb, encompassing the Mmrn1 gene in addition to Snca. Despite the lack of alpha-synuclein and multimerin-1 C57BL/6JOlaHsd animals do not display obvious phenotypes. Sequence comparisons revealed that the chromosomal organization of Sncg and Mmrn2 is highly reminiscent of the region containing Snca and Mmrn1, suggesting a duplication event of a cluster of apparently unrelated genes during evolution.
Specht
Christian G
CG
Laboratory for Molecular Pharmacology, Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
Schoepfer
Ralf
R
D000818:Animals; D001483:Base Sequence; D001798:Blood Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D017353:Gene Deletion; D020440:Gene Duplication; D051379:Mice; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D017422:Sequence Analysis, DNA; D051843:Synucleins; D051844:alpha-Synuclein
D001798:Blood Proteins; D009419:Nerve Tissue Proteins; C497605:Snca protein, mouse; D051843:Synucleins; D051844:alpha-Synuclein; C069282:multimerin