title: Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.
abstract: Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.
authors.affiliation: Medical Research Council Clinical Trials Unit, London, UK.
authors.forename: Krishnan
authors.initials: K
authors.lastname: Bhaskaran
authors.forename: Deenan
authors.initials: D
authors.lastname: Pillay
authors.forename: A Sarah
authors.initials: AS
authors.lastname: Walker
authors.forename: Martin
authors.initials: M
authors.lastname: Fisher
authors.forename: David
authors.initials: D
authors.lastname: Hawkins
authors.forename: Richard
authors.initials: R
authors.lastname: Gilson
authors.forename: Ken
authors.initials: K
authors.lastname: McLean
authors.forename: Kholoud
authors.initials: K
authors.lastname: Porter
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D015331:Cohort Studies; D024882:Drug Resistance, Viral / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006679:HIV Seropositivity / Q000276:immunology; D006801:Humans; D008231:Lymphopenia / Q000821:virology; D008297:Male