Frontotemporal dementia linked to chromosome 3.
A large pedigree with autosomal dominant frontotemporal dementia has been identified. Positional cloning has linked the disease gene to the pericentromeric region of chromosome 3. Clinical, neuropsychological, imaging, pathological and molecular genetic data are presented. The genetic mutation responsible for the disease has not been identified.
Brown
Jerry
J
Department of Neurology, Addenbrooke's Hospital, Cambridge, UK. jmb75@medschl.cam.ac.uk
Gydesen
Susanne
S
Johannsen
Peter
P
Gade
Anders
A
Skibinski
Gaia
G
Chakrabarti
Lisa
L
Brun
Arne
A
Spillantini
Maria
M
Yancopoulou
Despina
D
Thusgaard
Tove
T
Sorensen
Asger
A
Fisher
Elizabeth
E
Collinge
John
J
D001921:Brain / Q000473:pathology; D002893:Chromosomes, Human, Pair 3; D003704:Dementia / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D003718:Denmark; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D010641:Phenotype