title: Severe chronic active EBV infection in an adult patient: case report.
abstract: Severe chronic active Epstein-Barr virus (EBV) infection is a rare and life-threatening illness. Although the criteria for diagnosis include chronic or recurrent infectious mononucleosis-like symptoms lasting more than 6 months and high titers of anti-EBV antibodies, clinical and laboratory findings may be heterogeneous and flexible application of those criteria is necessary in cases showing typical clinical and pathologic findings. We report a case of severe chronic active EBV infection in a 62-yr-old female patient who showed classical clinical findings with infiltration of EBV-infected T lymphocytes in the bone marrow, spleen, and lymph nodes, and died four months after presentation.
authors.affiliation: Department of Pathology, Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Ha
authors.forename: Chul-Won
authors.initials: CW
authors.lastname: Chung
authors.forename: Young H
authors.initials: YH
authors.lastname: Ko
mesh_terms: D001854:Bone Marrow Cells / Q000821:virology; D017252:CD3 Complex / Q000096:biosynthesis; D015704:CD4 Antigens / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000401:mortality*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000821:virology; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D009929:Organ Size; D013154:Spleen / Q000473:pathology / Q000821:virology; D013601:T-Lymphocytes / Q000821:virology
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens