title: Subtype B human immunodeficiency virus (HIV) type 1 mutant that escapes detection in a fourth-generation immunoassay for HIV infection.
abstract: We report a case of human immunodeficiency virus (HIV) type 1 infection not detected by a highly sensitive combined antigen-antibody assay. The virus was a subtype B strain harboring a unique sequence within the immunodominant epitope of the transmembrane glycoprotein. Immunochemical analysis indicated that this sequence was probably responsible for the failure to detect HIV antibodies.
authors.affiliation: Laboratoire de Virologie, CHU Bretonneau, 37044 Tours Cedex, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Gaudy
authors.forename: Alain
authors.initials: A
authors.lastname: Moreau
authors.forename: Sylvie
authors.initials: S
authors.lastname: Brunet
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Descamps
authors.forename: Pascale
authors.initials: P
authors.lastname: Deleplanque
authors.forename: Denys
authors.initials: D
authors.lastname: Brand
authors.forename: Francis
authors.initials: F
authors.lastname: Barin
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000821:virology; D000328:Adult; D000595:Amino Acid Sequence; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000145:classification* / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: D015483:HIV Antibodies