title: [The spectrum and activity of urinary Ig-proteinases as a marker of chronic pyelonephritis].
abstract: OBJECTIVE
  To study the activity of Ig-splitting proteinases of various classes in the urine in patients with chronic pyelonephritis.
  
  
  METHODS
  Clinical, device and laboratory examinations were made in 50 patients (age 20-60 years). Admission and dynamic measurements were also made of the activity of serin, metal-dependent and thiol Ig-splitting proteinases in the urine.
  
  
  RESULTS
  Total proteolytic activity in the urine of the patients was higher than in healthy subjects. Thiol proteinase activity was detected in 98% cases. This activity was 100 times higher in the patients than in healthy subjects. Significant differences were registered in the activity of serin proteinases. After the treatment the level of serin proteinases approached the normal value while thiol proteinase activity decreased significantly (2-fold, on the average) but remained high. If this activity was high, the patients (70%) had 1-2 exacerbations annually, in low activity exacerbations were absent.
  
  
  CONCLUSIONS
  The activity of Ig-splitting proteinases of different classes is an important diagnostic and prognostic laboratory criterion of chronic pyelonephritis and can serve a criterion of treatment efficacy.
authors.forename: O D
authors.initials: OD
authors.lastname: Zinkevich
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Glushko
authors.forename: N A
authors.initials: NA
authors.lastname: Cafina
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Tiurin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000737:chemistry / Q000652:urine; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000737:chemistry / Q000652:urine*; D011237:Predictive Value of Tests; D011379:Prognosis; D011704:Pyelonephritis / Q000652:urine*
chemical_list: D015415:Biomarkers; D007136:Immunoglobulins; D010447:Peptide Hydrolases