Ribosome-inactivating proteins: entry into mammalian cells and intracellular routing.
To catalytically-modify ribosomes in vivo, ribosome-inactivating proteins produced by plants must enter susceptible mammalian cells in order to reach their substrates in the cytosol. This review primarily focuses on the biosynthesis, mechanism of cell entry and intracellular trafficking of ricin, the most thoroughly studied ribosome-inactivating protein in this respect.
Roberts
Lynne M
LM
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK. lynne-roberts@warwick.ac.uk
Lord
J Michael
JM
D000818:Animals; D004705:Endocytosis; D021381:Protein Transport; D012270:Ribosomes / Q000187:drug effects*; D012276:Ricin / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
D012276:Ricin