title: [Present situation in the study of antisperm antibodies].
abstract: Immune factors account for 5%-15% of male infertility. Because of the diversity in molecular weight, structure and location, sperm antigens play different roles in immune infertility. Antisperm antibodies (AsAb) influence sperm function not only by direct action, but also by changing the local microenvironment indirectly. This paper reviews the progress in the studies of the implication of human sperm antigens, the function, mechanisms, categories and titer of AsAb in male infertility.
authors.affiliation: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. guangwei30@163.com
authors.forename: Guangwei
authors.initials: G
authors.lastname: Li
authors.forename: Guanghui
authors.initials: G
authors.lastname: Du
authors.forename: Weimin
authors.initials: W
authors.lastname: Yang
mesh_terms: D000906:Antibodies / Q000276:immunology*; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000276:immunology; D008297:Male; D012098:Reproduction; D013094:Spermatozoa / Q000276:immunology*
chemical_list: D000906:Antibodies; D007132:Immunoglobulin Isotypes