title: Recombination does not generate pinworm susceptibility during experimental crosses between two mouse subspecies.
abstract: The susceptibility to Aspiculuris tetraptera of European Mus musculus hybrids is thought to reflect the disruption of genomic co-adaptation through recombination of the parental genomes. Here, we compared the susceptibility to this parasite between parents and experimental hybrids (intersubspecific until F4, intrasubspecific F1, F2) to clarify the contributions of heterosis and subspecies incompatibility. F1 showed hybrid vigor. Unlike intrasubspecific F2, intersubspecific F2 were less resistant than F1, but revealed no increased susceptibility relative to the parents. Intersubspecific F3 and F4 showed the same hybrid vigor as F1. Heterosis contributed most to the resistance, but the differences between intra- and intersubspecific F2 suggested genomic incompatibilities between subspecies. However, the susceptibility did not increase through the recombination process, showing that disruption of co-adaptation does not directly affect resistance. Even if previous studies still support the selective role of parasites in the current hybrid zone, an alternative hypothesis on the origin of hybrid susceptibility is warranted.
authors.affiliation: Laboratoire Génome, Populations, Interactions, Adaptations, UMR 5171 CNRS-UMII-IFREMER, Université de Montpellier II, Bat. 24, CC105, Place E. Bataillon, 34095 Cedex 5 Montpellier, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Derothe
authors.forename: Adeline
authors.initials: A
authors.lastname: Porcherie
authors.forename: Marco
authors.initials: M
authors.lastname: Perriat-Sanguinet
authors.forename: Claude
authors.initials: C
authors.lastname: Loubès
authors.forename: Catherine
authors.initials: C
authors.lastname: Moulia
mesh_terms: D000818:Animals; D000835:Animals, Wild; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D017229:Enterobiasis / Q000235:genetics* / Q000469:parasitology; D004757:Enterobius / Q000254:growth & development*; D005260:Female; D020022:Genetic Predisposition to Disease; D006823:Hybrid Vigor / Q000235:genetics; D006824:Hybridization, Genetic; D007113:Immunity, Innate / Q000235:genetics*; D008297:Male; D051379:Mice; D011995:Recombination, Genetic; D012727:Sex Characteristics; D013045:Species Specificity