CD4 T-lymphocyte subset counts in HIV-seropositive patients during the course of community-acquired pneumonia caused by Streptococcus pneumoniae.
Total lymphocyte counts, CD4 T-lymphocyte counts and CD4/CD8 ratios were measured in 30 anti-retroviral-naive HIV-seropositive patients upon hospital admission for acute community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae, and again 1 month after resolution of infection. There was a significant depression of the total lymphocyte count (p < 0.005) and CD4 T-lymphocyte count (p < 0.001) in the acute stage of CAP caused by S. pneumoniae, with a subsequent increase in 90% (27/30) of cases after resolution of the infection. There was no significant difference in the CD4/CD8 T-lymphocyte ratio on admission compared with 1 month later (p 0.9).
Schleicher
G K
GK
Department of Medicine, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa. Schleicher@worldonline.co.za
Hopley
M J
MJ
Feldman
C
C
D000328:Adult; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D017714:Community-Acquired Infections / Q000276:immunology* / Q000382:microbiology; D005260:Female; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology*; D006801:Humans; D008297:Male; D011018:Pneumonia, Pneumococcal / Q000276:immunology* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000276:immunology