APOE genotype effects on Alzheimer's disease onset and epidemiology.
The risk of developing Alzheimer's disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many populations. This paper reviews the onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with age.
Ashford
J Wesson
JW
Stanford/VA Alzheimer Center, Palo Alto, CA 94304-1207, USA. ashford@stanford.edu
D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics*; D002487:Centers for Disease Control and Prevention, U.S.; D005838:Genotype; D006801:Humans; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D001057:Apolipoproteins E