Preserved verb generation in patients with cerebellar atrophy.
A role of the right cerebellar hemisphere has been suggested in linguistic functions. Nevertheless, studies of verb generation in cerebellar patients provide inconsistent results. The aim of the present study was to examine verb generation in a larger group of cerebellar patients with well-defined lesions. Ten subjects with degenerative cerebellar disorders and ten healthy matched controls participated. Subjects had to generate verbs to the blocked presentation of photographs of objects (i.e. four blocks of sixteen objects). As control condition, the objects had to be named. Furthermore, dysarthria was quantified by means of a sentence production and syllable repetition task. Volumetric analysis of individual 3D-MR scans was performed to quantify cerebellar atrophy. Cerebellar patients were slower in the sentence production and syllable repetition tasks, and cerebellar volume was decreased compared to controls. Despite cerebellar atrophy and dysarthria, the answers produced did not differ between patients and controls. In addition, both groups revealed the same amount of decrease in verbal reaction time over blocks (i.e. learning). The results suggest that the role of the cerebellum in verb generation is less pronounced than previously suggested.
Richter
S
S
Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. s.richter@uni-essen.de
Kaiser
O
O
Hein-Kropp
C
C
Dimitrova
A
A
Gizewski
E
E
Beck
A
A
Aurich
V
V
Ziegler
W
W
Timmann
D
D
D000328:Adult; D000368:Aged; D001284:Atrophy; D002524:Cerebellar Ataxia / Q000150:complications / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology*; D004401:Dysarthria / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007807:Language Tests; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D012016:Reference Values; D012044:Regression Analysis; D012720:Severity of Illness Index; D014705:Verbal Behavior / Q000502:physiology*; D014825:Vocabulary