title: Effect of knee osteoarthritis on the perception of quality of life in Venezuelan patients.
abstract: OBJECTIVE
  To measure the perception of quality of life in Venezuelan patients with knee osteoarthritis and to identify those variables that may influence it.
  
  
  METHODS
  A multicenter, cross-sectional study of 126 mestizo patients with knee osteoarthritis recruited from 8 rheumatology centers in Venezuela. We used a Spanish-translated version of the Arthritis Impact Measurement Scales (AIMS), as adapted in Venezuela. One-way analysis of variance was used to compare the AIMS mean total score among subgroups of knee pain, anatomic stage, and socioeconomic status (SES); a post-hoc test was performed to identify significant intragroup differences. Pearson's correlation coefficient was used to examine correlations between age, body mass index (BMI), disease duration, knee pain, and AIMS score. Associations between radiologic stage, SES, and AIMS scores were examined using Spearman's rank correlation. Multiple regression analysis was used to estimate predictor factors of AIMS scores.
  
  
  RESULTS
  A significant correlation was found between total AIMS scores and knee pain, age, and socioeconomic status, but not with BMI, disease duration, or anatomic stage. Patients with severe knee pain differed from those with mild and moderate pain, and the highest AIMS mean total score was seen in patients within the severe knee pain subset. Patients in the highest socioeconomic levels differed from those within lowest categories. Patients classified as being at the levels of relative and critical poverty showed the highest AIMS scores. Multiple regression analysis showed that knee pain was the only variable that exerted an independent effect on the quality of life in our patients.
  
  
  CONCLUSIONS
  The perception of quality of life is negatively affected by increasing levels of joint pain, old age, and low socioeconomic status in Venezuelan patients with knee osteoarthritis. Our study supports the need for an early and vigorous approach to treat pain in this group of patients.
authors.affiliation: Centro Nacional de Enfermedades Reumáticas, Ministerio de Salud y Desarrollo Social, Caracas, Venezuela.
authors.forename: José G
authors.initials: JG
authors.lastname: Chacón
authors.forename: Nancy E
authors.initials: NE
authors.lastname: González
authors.forename: Aleida
authors.initials: A
authors.lastname: Véliz
authors.forename: Benito R
authors.initials: BR
authors.lastname: Losada
authors.forename: Hernando
authors.initials: H
authors.lastname: Paul
authors.forename: Luís G
authors.initials: LG
authors.lastname: Santiago
authors.forename: Ana
authors.initials: A
authors.lastname: Antúnez
authors.forename: Yelitza
authors.initials: Y
authors.lastname: Finol
authors.forename: María E
authors.initials: ME
authors.lastname: González
authors.forename: Isabel
authors.initials: I
authors.lastname: Granados
authors.forename: Irama
authors.initials: I
authors.lastname: Maldonado
authors.forename: Teolinda
authors.initials: T
authors.lastname: Maldonado
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín
authors.forename: Gisela
authors.initials: G
authors.lastname: Zambrano
authors.forename: Martín A
authors.initials: MA
authors.lastname: Rodríguez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology* / Q000523:psychology*; D010146:Pain / Q000503:physiopathology; D011788:Quality of Life; D012044:Regression Analysis; D012649:Self Concept; D012720:Severity of Illness Index; D012923:Social Class; D014687:Venezuela