Effect of D-serine on a delayed match-to-place task for the water maze.
The effect of the amino acid d-serine, a partial NMDA receptor agonist, on a delayed match-to-place task in the water maze was examined. Twenty-four male rats were first trained to attain baseline measurements, then administered D-serine or saline. Rats administered D-serine (100 mg/kg, i.p.) before swim trials did not show a decrease in escape latencies, but did show an increase in swim time spent within the previous days' escape platform location.
Stouffer
Eric M
EM
Department of Psychology, Laboratory of Comparative Neuropsychology, Towson University, Towson, MD 21252-0001, USA. estouf@ego.psych.mcgill.ca
Petri
Herbert L
HL
Devan
Bryan D
BD
D000818:Animals; D001522:Behavior, Animal; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists*; D012694:Serine / Q000494:pharmacology*; D013028:Space Perception / Q000187:drug effects*; D013647:Task Performance and Analysis; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine