title: Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population.
abstract: Ten genome-wide scans have been conducted over the past few years in the search for psoriasis susceptibility genes, but only one potential susceptibility region has been consistently replicated. A meta-analysis using the genome-search meta-analysis method was undertaken combining the results of six of these psoriasis genome-wide studies. The results of this analysis revealed linkage to the major histocompatibility complex on chromosome 6p21 that includes the PSORS1 locus. In addition, linkage was also recorded to a region on chromosome 4q28-q31 previously identified only in a Chinese Hans population. Both these regions were statistically significant even after correction for multiple testing. A possible reason for the erratic replication of findings could be the large effect of the PSORS1 locus (6p21) masking the effect of other loci involved in psoriasis. To overcome this problem, we suggest that future studies condition on the effect of the PSORS1 locus.
authors.affiliation: Biomedical Genetics Project, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK. g.sagoo@sheffield.ac.uk
authors.forename: Gurdeep S
authors.initials: GS
authors.lastname: Sagoo
authors.forename: Rachid
authors.initials: R
authors.lastname: Tazi-Ahnini
authors.forename: Jonathan W N
authors.initials: JW
authors.lastname: Barker
authors.forename: James T
authors.initials: JT
authors.lastname: Elder
authors.forename: Rajan P
authors.initials: RP
authors.lastname: Nair
authors.forename: Lena
authors.initials: L
authors.lastname: Samuelsson
authors.forename: Heiko
authors.initials: H
authors.lastname: Traupe
authors.forename: Richard C
authors.initials: RC
authors.lastname: Trembath
authors.forename: Darren A
authors.initials: DA
authors.lastname: Robinson
authors.forename: Mark M
authors.initials: MM
authors.lastname: Iles
mesh_terms: D044466:Asian People / Q000235:genetics; D002894:Chromosomes, Human, Pair 4; D002896:Chromosomes, Human, Pair 6; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D011565:Psoriasis / Q000235:genetics*; D044465:White People / Q000235:genetics