title: Linear deposition of immunoglobulins and complement components on the dura in normal pressure hydrocephalus complicating systemic lupus erythematosus.
abstract: We present a case of normal pressure hydrocephalus in a 70-year-old man with previously diagnosed systemic lupus erythematosus. Histological examination demonstrated the linear deposition of IgG, IgA, IgM, C(3) and C(1q) on the dura in the absence of inflammation or thrombosis that has previously been implicated in the aetiology of elevated pressure hydrocephalus in systemic lupus erythematosus. Our results suggest that the deposition of immunoglobulins and complement may play a pivotal role in an insidious manner in the pathogenesis of normal pressure hydrocephalus in systemic lupus erythematosus.
authors.affiliation: Department of Neurology, Hikone Municipal Hospital, Japan. hxk54@cwru.edu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Honda
authors.forename: Masao
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kaneko
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kamei
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tatsumi
authors.forename: Nozomu
authors.initials: N
authors.lastname: Murai
authors.forename: Yohei
authors.initials: Y
authors.lastname: Mineharu
authors.forename: Jiro
authors.initials: J
authors.lastname: Oita
mesh_terms: D000368:Aged; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications / Q000276:immunology / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000276:immunology / Q000378:metabolism; D008297:Male
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins