title: [Effect of jiangu granule on quality of bone in model rats with osteoporosis induced by ovariectomy].
abstract: OBJECTIVE
  To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis.
  
  
  METHODS
  Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer.
  
  
  RESULTS
  JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur.
  
  
  CONCLUSIONS
  JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.
authors.affiliation: Faculty of Orthopedics and Traumatology, Fujian College of TCM, Fuzhou 350003. ypling@sina.com.cn
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Lin
authors.forename: Rui-xiang
authors.initials: RX
authors.lastname: Zhou
authors.forename: Shi-ming
authors.initials: SM
authors.lastname: Guo
mesh_terms: D015502:Absorptiometry, Photon; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D010052:Ovariectomy; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004365:Drugs, Chinese Herbal