title: The use of bioabsorbable implants in spine surgery.
abstract: The use of bioabsorbable implants in spine surgery is expanding at a rapid pace. These implants are mimicking the roles of traditional metallic devices and are demonstrating similar efficacy in terms of maintaining stability and acting as carriers for grafting substances. Biomechanical studies have demonstrated their ability to stabilize effectively a degenerative cervical and lumbar motion segment. In numerous animal models, researchers have illustrated the ability of bioabsorbable implants to function satisfactorily as an interbody spacer and to achieve satisfactory bone fusion. Investigators have explored various opportunities for these implants to replace their metallic counterparts in clinical studies conducted in humans. The gradual resorption of these implants appears effectively to transfer gradual loads to the grafting substances promoting the biological mechanisms of fusion. Novel uses of bioabsorbable technology are constantly evolving. Their future as a carrier of biological agents such as bone morphogenetic proteins and bone graft extenders, their radiolucency, and their eventual resorption make them an ideal implant for use in spinal degenerative disease.
authors.affiliation: Department of Orthopaedic Surgery, Thomas Jefferson University Hospital, Rothman Institute, Philadelphia, Pennsylvania 1907, USA.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Robbins
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Vaccaro
authors.forename: Luke
authors.initials: L
authors.lastname: Madigan
mesh_terms: D020341:Absorbable Implants / Q000639:trends; D000818:Animals; D016025:Bone Transplantation / Q000379:methods; D005069:Evaluation Studies as Topic; D006801:Humans; D011474:Prosthesis Design; D013122:Spinal Diseases / Q000175:diagnosis / Q000628:therapy*; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods