title: Brassica juncea (Rai) significantly prevented the development of insulin resistance in rats fed fructose-enriched diet.
abstract: Brassica juncea (BJ; Hindi name: Rai) seeds and Murraya koenigii (MK; English names: Curry leaves) leaves, used as food ingredients and also by diabetics in India, were assessed in a fructose-mediated non-genetic model of insulin resistance. Feeding of fructose rich diet for 30 days resulted in rise in blood glucose by 29.4%, insulin by 101.2% and cholesterol by 26.7% indicating development of insulin resistance. However, feeding of a fructose diet containing 10% Brassica juncea seeds powder for 30 days significantly decreased fasting serum glucose, insulin and cholesterol levels but did not normalize them. On the other hand, a diet containing 15% Murraya koenigii leaves powder failed to exert any effect on these parameters. Results of the present study suggests that BJ can play a role in management of pre-diabetic state of insulin resistance and should be promoted for use in patients prone to diabetes.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110049, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Yadav
authors.forename: V
authors.initials: V
authors.lastname: Vats
authors.forename: A C
authors.initials: AC
authors.lastname: Ammini
authors.forename: J K
authors.initials: JK
authors.lastname: Grover
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D005632:Fructose / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009149:Mustard Plant; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005632:Fructose