Microwave-accelerated SPOT-synthesis on cellulose supports.
[reaction: see text] We demonstrate that microwave irradiation can dramatically accelerate reaction rates for spatially addressable library synthesis on planar membrane supports. The development of a robust support/linker system, microwave-assisted synthesis of small molecule test libraries, and methods for solid-phase scale-up on cellulose are described.
Bowman
Matthew D
MD
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1322, USA.
Jeske
Ryan C
RC
Blackwell
Helen E
HE
D002482:Cellulose / Q000737:chemistry*; D047188:Chalcones / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008567:Membranes, Artificial; D008872:Microwaves; D015394:Molecular Structure; D013499:Surface Properties
D047188:Chalcones; D007659:Ketones; D008567:Membranes, Artificial; D002482:Cellulose