title: The next generation in shock resuscitation.
abstract: Resuscitation of the severely injured patient who presents in shock has improved greatly, following focused wartime experience and insight from laboratory and clinical studies. Further benefit is probable from technologies that are being brought into clinical use, especially hypertonic saline dextran, haemoglobin-based oxygen carriers, less invasive early monitors, and medical informatics. These technologies could improve the potential of prehospital and early hospital care to pre-empt or more rapidly reverse hypoxaemia, hypovolaemia, and onset of shock. Damage control surgery and definitive interventional radiology will probably combine with more real-time detection and intervention for hypothermia, coagulopathy, and acidosis, to avoid extreme pathophysiology and the "bloody vicious cycle". Although now widely practised as standard of care in the USA and Europe, shock resuscitation strategies involving haemoglobin replacement and fluid volume loading to regain tissue perfusion and oxygenation vary between trauma centres. One of the difficulties is the scarcity of published evidence for or against seemingly basic intervention strategies, such as early or large-volume fluid loading. Standardised protocols for resuscitation, representing the best and most current knowledge of the clinical process, could be devised and widely implemented as interactive computerised applications among trauma centres in the USA and Europe. Prevention of injury is preferable and feasible, but early care of the severely injured patient and modulation of exaggerated systemic inflammatory response due to transfusion and other complications of traditional strategies will probably provide the next generation of improvements in shock resuscitation.
authors.affiliation: Department of Surgery, University of Texas-Houston Medical School, Houston, TX 77030, USA. Frederick.A.Moore@uth.tmc.edu
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Moore
authors.forename: Bruce A
authors.initials: BA
authors.lastname: McKinley
authors.forename: Ernest E
authors.initials: EE
authors.lastname: Moore
mesh_terms: D000818:Animals; D001802:Blood Substitutes; D002302:Cardiac Output; D003102:Colloids; D000077324:Crystalloid Solutions; D006454:Hemoglobins / Q000032:analysis; D006489:Hemostatic Techniques; D006801:Humans; D007552:Isotonic Solutions; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D010952:Plasma Substitutes; D012151:Resuscitation / Q000379:methods; D012462:Saline Solution, Hypertonic; D012771:Shock, Hemorrhagic / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D015996:Survival Rate; D065227:Transfusion Reaction
chemical_list: D001802:Blood Substitutes; D003102:Colloids; D000077324:Crystalloid Solutions; D006454:Hemoglobins; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D012462:Saline Solution, Hypertonic; D010100:Oxygen