title: A novel in vivo procedure for volumetric flow measurements.
abstract: We report on a novel procedure for invasive volumetric blood flow measurements using a commercially available Doppler flow wire system, which could, until now, only measure flow velocity. We here describe a method applicable in vivo to generate both velocity and cross-sectional area information from the same pulsed-wave Doppler signal for volumetric flow assessment. We demonstrate its feasibility and validation in vivo in pig coronary arteries. Our Doppler-derived volumetric flow measurements were compared with the respective transit-time flow and showed an excellent correlation (r = 0.969; p < 0.0001). Agreement between transit-time and Doppler-derived flow measurements could be observed for flow conditions ranging from 30 to 180 mL/min. The mean values for the two methods were 71.4 +/- 43.7 mL/min and 71.3 +/- 42.2 mL/min, respectively. We conclude that this technique might possibly be introduced into future clinical practice as an invasive procedure of choice for the assessment of volumetric blood flow.
authors.affiliation: Echocardiography, Division of Cardiology, Cardiovascular Center, University Hospital, Zurich, Switzerland. karjer@usz.unizh.ch
authors.forename: Rolf
authors.initials: R
authors.lastname: Jenni
authors.forename: Felix
authors.initials: F
authors.lastname: Matthews
authors.forename: Schlomo V
authors.initials: SV
authors.lastname: Aschkenasy
authors.forename: Mario
authors.initials: M
authors.lastname: Lachat
authors.forename: Bernd
authors.initials: B
authors.lastname: van Der Loo
authors.forename: Erwin
authors.initials: E
authors.lastname: Oechslin
authors.forename: Mehdi
authors.initials: M
authors.lastname: Namdar
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Jiang
authors.forename: Philipp A
authors.initials: PA
authors.lastname: Kaufmann
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D018619:Echocardiography, Doppler, Pulsed / Q000295:instrumentation / Q000379:methods*; D005240:Feasibility Studies; D012039:Regional Blood Flow; D013552:Swine