Giant intracranial Rosai-Dorfman disease.
Rosai-Dorfman disease is a rare, non-neoplastic disease characterized by an unusual proliferation of histiocytic cells. It rarely manifests intracranially, and only 50 cases of intracranial lesions have been reported. We describe an unusual case of a huge, solid mass in the paranasal sinuses, orbits, cavernous sinuses, and suprasellar cisterns. A 29-year-old patient was admitted to our hospital with nasal obstruction and proptosis and visual loss in the right eye. A biopsy was done at another institution and the diagnosis was "pseudotumor of orbit". A right-sided cranio-orbitozygomatic craniotomy combined with a right-sided lateral rhinotomy was used to excise the tumor with right orbital exenteration. The histopathological diagnosis was consistent with Rosai-Dorfman disease. The patient underwent postoperative chemotherapy. Involvement of the central nervous system in Rosai-Dorfman disease is rare, but the disease's ability to mimic other pathologies underlines its importance.
Türe
Uğur
U
Department of Neurosurgery, Marmara University School of Medicine, Istanbul, Turkey. ugurture@tnn.net
Seker
Aşkin
A
Bozkurt
Süheyla Uyar
SU
Uneri
Cüneyt
C
Sav
Aydin
A
Pamir
M Necmettin
MN
D000328:Adult; D003399:Craniotomy / Q000379:methods; D015618:Histiocytosis, Sinus / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010256:Paranasal Sinuses / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed / Q000379:methods