[Statin-induced rhabdomyolysis and renal failure: also with fluvastatine].
Hydroximetilglutaril-coenzima A reductase inhibitors (statin) have the potential to cause rhabdomyolysis. However, fluvastatin is rarely associated with rhabdomyolysis when compared to other statins. Differences in biochemical and pharmacokinetic properties between fluvastatin and the other statins have been invocated in order to explain the apparent comparative safety of fluvastatin. We present a case of rhabdomyolysis with acute renal failure in a patient receiving fluvastatin and, following the Karch-Lasagne algorithm, we present evidence that this case was an adverse reactions to fluvastatin.
Lado Lado
F L
FL
Servicio de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela, A Coruña, Spain. flladol@usc.es
Rodríguez Moreno
C
C
Cinza Sajurjo
S
S
Durán Parrondo
C
C
Pazo Núñez
M
M
Lois Pernas
A
A
Masa Vázquez
L
L
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects*; D005260:Female; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D007211:Indoles / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced*
D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin