title: Antifungal cyclopentenediones from Piper coruscans.
abstract: Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida albicans and its azole-resistant strains and may serve as a template for a new class of antifungal agents.
authors.affiliation: National Center for Natural Products Research, Mississippi, USA. xcli7@olemiss.edu
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Li
authors.forename: Daneel
authors.initials: D
authors.lastname: Ferreira
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Zhang
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Hala N
authors.initials: HN
authors.lastname: ElSohly
authors.forename: Dale G
authors.initials: DG
authors.lastname: Nagle
authors.forename: Troy J
authors.initials: TJ
authors.lastname: Smillie
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: Larry A
authors.initials: LA
authors.lastname: Walker
authors.forename: Alice M
authors.initials: AM
authors.lastname: Clark
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D003517:Cyclopentanes; C013905:cyclopentenone