title: Molecular modeling on DNA cleavage activity of seryl-histidine and related dipeptide.
abstract: Molecular interaction between seryl-histidine (or seryl-histidine related dipeptides) and DNA model molecule 5'-TpTpdC-3' was studied by a molecular docking procedure. The key structural features of DNA cleaving activity were investigated.
authors.affiliation: The Key Laboratory of Bioorganic Phosphorous Chemistry, Ministry of Education, China, Department of Chemistry, Tsinghua University, Beijing 100084, China. sunm@sun5.ibp.ac.cn
authors.forename: Ming
authors.initials: M
authors.lastname: Sun
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ma
authors.forename: Sanhao
authors.initials: S
authors.lastname: Ji
authors.forename: Huanai
authors.initials: H
authors.lastname: Liu
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000187:drug effects / Q000378:metabolism*; D004151:Dipeptides / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D013816:Thermodynamics
chemical_list: D004151:Dipeptides; C422849:seryl-histidine; D004247:DNA