Urotensin-II, a neuropeptide ligand for GPR14, induces c-fos in the rat brain.
The vasoactive peptide urotensin-II and its receptor, GPR14 (now known as UT receptor), are localised in the mammalian central nervous system. Accordingly, various centrally mediated effects of urotensin-II on behaviour, neuroendocrine hormones and neurochemistry have been described. To investigate neuroanatomical substrates for the central actions of urotensin-II, expression of the immediate early gene c-fos was examined following intracerebroventricular administration to rats. Urotensin-II increased Fos expression in the cingulate cortex and periaqueductal grey, suggesting important central roles for urotensin-II and its receptor.
Gartlon
Jane E
JE
Psychiatry CEDD, GlaxoSmithKline, Third Avenue, Harlow, Essex CM19 5AW, UK. jane.gartlon@gsk.com
Ashmeade
Tracey
T
Duxon
Mark
M
Hagan
Jim J
JJ
Jones
Declan N C
DN
D000818:Animals; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression / Q000187:drug effects / Q000235:genetics; D006179:Gyrus Cinguli / Q000187:drug effects / Q000502:physiology; D007276:Injections, Intraventricular; D008024:Ligands; D008297:Male; D020644:Midline Thalamic Nuclei / Q000187:drug effects / Q000502:physiology; D009479:Neuropeptides / Q000737:chemistry / Q000494:pharmacology*; D010487:Periaqueductal Gray / Q000187:drug effects / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics* / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects* / Q000502:physiology; D006113:United Kingdom; D014579:Urotensins / Q000737:chemistry / Q000494:pharmacology*
D008024:Ligands; D009479:Neuropeptides; D016760:Proto-Oncogene Proteins c-fos; D043562:Receptors, G-Protein-Coupled; D014579:Urotensins; C473142:Uts2r protein, rat; C029677:urotensin II