Criteria for predicting the recurrence and metastasis of stage I and II gastric cancer without lymph node metastasis.
This study examined whether detection of occult neoplastic cells (ONCs) in lymph nodes or the high-risk criteria for recurrence/metastasis of colorectal cancer were useful for predicting the recurrence of primary gastric cancer. The subjects were 122 patients with node-negative stage I or stage II primary gastric cancer. Prediction of recurrence using ONCs showed a sensitivity of 25.0% (2/8), specificity of 97.1% (100/103), and accuracy of 61.1% in stage I patients, while the respective values were 75.0% (3/4), 100.0% (7/7), and 87.5% in stage II patients. Prediction of recurrence in patients who fulfilled 2 or more of the high-risk criteria showed a sensitivity of 37.5% (3/8), specificity of 94.2% (97/103), and accuracy of 65.9% for stage I patients, while the respective values were 100.0% (4/4), 85.7% (6/7), and 92.9% for stage II patients. These results suggest that the prediction of recurrence based on the high-risk criteria shows a high sensitivity, specificity, and accuracy in patients of stage II gastric cancer without lymph node metastasis.
Mukai
Masaya
M
Department of Surgery, Tokai University Oiso Hospital, Oiso, Kanagawa 259-0198, Japan. onc-res@oiso.u-tokai.ac.jp
Sato
Shinkichi
S
Kimura
Tomomi
T
Komatsu
Nobukazu
N
Ninomiya
Hiromi
H
Nakasaki
Hisao
H
Ogoshi
Kyouji
K
Makuuchi
Hiroyasu
H
D006801:Humans; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis / Q000473:pathology*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000473:pathology*