[Effect of trimecaine derivatives and lidocaine on hemodynamics].
The results of experiments on cats showed that quaternidine, a quaternary ammonium derivative of trimecaine, does not induce significant variations in the hemodynamic parameters, being advantageous in this respect to some well-known antiarrhythmic drugs. LKhT-3-00 (dialkylaminophenylacetamide glutaminate)--a tertiary derivative of lidocaine--leads to a slight decrease in the heart rate, an insignificant decrease in the arterial pressure for 10 min, and a pronounced enhancement of the pumping ability of the left ventricle over a time period of 30 min.
Blinov
D S
DS
Department of Pharmacology, Mordivinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Kostin
Ia V
IaV
Volkova
N D
ND
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D002415:Cats; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008012:Lidocaine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects*; D014288:Trimecaine / Q000009:adverse effects* / Q000031:analogs & derivatives
D000889:Anti-Arrhythmia Agents; D000644:Quaternary Ammonium Compounds; C482579:quaternidine; D008012:Lidocaine; D014288:Trimecaine