[Delayed response of the red blood system (erythron) to carboplatin administration during pregnancy].
Pregnant rats exhibited regenerative anemia development 3 months upon a single intravenous injection of carboplatin in a maximum tolerated dose; the effect increased by the end of pregnancy. The character of changes in parameters of the peripheral and central erythron parts (increased level of erythrocyte hemolysis, decrease in the amount of erythrocytes, increase in the number of reticulocytes, development of erythropoietic hyperplasia in bone marrow and spleen) was indicative of the hemolytic type of anemia.
Karpova
G V
GV
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Borovskaia
T G
TG
Timina
E A
EA
Pakhomova
A V
AV
D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced*; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016190:Carboplatin / Q000009:adverse effects*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000139:chemically induced*; D051381:Rats; D017208:Rats, Wistar; D017701:Reticulocyte Count; D013997:Time Factors
D000970:Antineoplastic Agents; D006454:Hemoglobins; D016190:Carboplatin