title: Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice.
abstract: T cell-derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleukin 31 (IL-31), which is preferentially produced by T helper type 2 cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. Expression of IL-31 receptor A and oncostatin M receptor mRNA was induced in activated monocytes, whereas epithelial cells expressed both mRNAs constitutively. Transgenic mice overexpressing IL-31 developed severe pruritus, alopecia and skin lesions. Furthermore, IL-31 receptor expression was increased in diseased tissues derived from an animal model of airway hypersensitivity. These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases.
authors.affiliation: Department of Immunology, ZymoGenetics, 1201 Eastlake Avenue East, Seattle, Washington 98102, USA.
authors.forename: Stacey R
authors.initials: SR
authors.lastname: Dillon
authors.forename: Cindy
authors.initials: C
authors.lastname: Sprecher
authors.forename: Angela
authors.initials: A
authors.lastname: Hammond
authors.forename: Janine
authors.initials: J
authors.lastname: Bilsborough
authors.forename: Maryland
authors.initials: M
authors.lastname: Rosenfeld-Franklin
authors.forename: Scott R
authors.initials: SR
authors.lastname: Presnell
authors.forename: Harald S
authors.initials: HS
authors.lastname: Haugen
authors.forename: Mark
authors.initials: M
authors.lastname: Maurer
authors.forename: Brandon
authors.initials: B
authors.lastname: Harder
authors.forename: Janet
authors.initials: J
authors.lastname: Johnston
authors.forename: Susan
authors.initials: S
authors.lastname: Bort
authors.forename: Sherri
authors.initials: S
authors.lastname: Mudri
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Kuijper
authors.forename: Tom
authors.initials: T
authors.lastname: Bukowski
authors.forename: Pamela
authors.initials: P
authors.lastname: Shea
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Dong
authors.forename: Maria
authors.initials: M
authors.lastname: Dasovich
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Grant
authors.forename: Luann
authors.initials: L
authors.lastname: Lockwood
authors.forename: Steven D
authors.initials: SD
authors.lastname: Levin
authors.forename: Cosette
authors.initials: C
authors.lastname: LeCiel
authors.forename: Kim
authors.initials: K
authors.lastname: Waggie
authors.forename: Heather
authors.initials: H
authors.lastname: Day
authors.forename: Stavros
authors.initials: S
authors.lastname: Topouzis
authors.forename: Janet
authors.initials: J
authors.lastname: Kramer
authors.forename: Rolf
authors.initials: R
authors.lastname: Kuestner
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Don
authors.initials: D
authors.lastname: Foster
authors.forename: Julia
authors.initials: J
authors.lastname: Parrish-Novak
authors.forename: Jane A
authors.initials: JA
authors.lastname: Gross
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D003872:Dermatitis / Q000276:immunology* / Q000473:pathology*; D005434:Flow Cytometry; D017353:Gene Deletion; D020869:Gene Expression Profiling; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000473:pathology; D015918:Infusion Pumps, Implantable; D007378:Interleukins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D008168:Lung / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D018121:Receptors, Cytokine / Q000235:genetics; D018123:Receptors, Interleukin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D053677:Receptors, Oncostatin M; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D019076:Transgenes / Q000235:genetics; D015854:Up-Regulation
chemical_list: C488159:Il31ra protein, mouse; D007378:Interleukins; D012333:RNA, Messenger; D018121:Receptors, Cytokine; D018123:Receptors, Interleukin; D053677:Receptors, Oncostatin M