Hemocompatibility of nitrogen-doped, hydrogen-free diamond-like carbon prepared by nitrogen plasma immersion ion implantation-deposition.
Amorphous hydrogenated carbon (a-C:H) has been shown to be a potential material in biomedical devices such as artificial heart valves, bone implants, and so on because of its chemical inertness, low coefficient of friction, high wear resistance, and good biocompatibility. However, the biomedical characteristics such as blood compatibility of doped hydrogen-free diamond-like carbon (DLC) have not been investigated in details. We recently began to investigate the potential use of nitrogen-doped, hydrogen-free DLC in artificial heart valves. In our experiments, a series of hydrogen-free DLC films doped with nitrogen were synthesized by plasma immersion ion implantation-deposition (PIII-D) utilizing a pulsed vacuum arc plasma source and different N to Ar (FN/FAr) gas mixtures in the plasma chamber. The structures and properties of the film were evaluated by Raman spectroscopy, Rutherford backscattering spectrometry (RBS), and X-ray photoelectron spectroscopy (XPS). To assess the blood compatibility of the films and the impact on the blood compatibility by the presence of nitrogen, platelet adhesion tests were conducted. Our results indicate that the blood compatibility of both hydrogen-free carbon films (a-C) and amorphous carbon nitride films are better than that of low-temperature isotropic pyrolytic carbon (LTIC). The experimental results are consistent with the relative theory of interfacial energy and surface tension including both dispersion and polar components. Our results also indicate that an optimal fraction of sp2 bonding is desirable, but an excessively high nitrogen concentration degrades the properties to an extent that the biocompatibility can be worse than that of LTIC.
Kwok
Sunny C H
SC
Department of Physics and Material Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.
Yang
Ping
P
Wang
Jin
J
Liu
Xuanyong
X
Chu
Paul K
PK
D000418:Albumins / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001769:Blood / Q000187:drug effects*; D002244:Carbon / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018130:Diamond / Q000737:chemistry*; D005340:Fibrinogen / Q000737:chemistry; D006350:Heart Valve Prosthesis; D006801:Humans; D006859:Hydrogen / Q000737:chemistry; D066298:In Vitro Techniques; D007477:Ions; D009584:Nitrogen / Q000737:chemistry*; D010973:Platelet Adhesiveness / Q000187:drug effects; D012542:Scattering, Radiation; D013052:Spectrometry, X-Ray Emission; D013059:Spectrum Analysis, Raman; D013499:Surface Properties; D013500:Surface Tension
D000418:Albumins; D001672:Biocompatible Materials; D007477:Ions; D002244:Carbon; D018130:Diamond; D006859:Hydrogen; D005340:Fibrinogen; D009584:Nitrogen