[Activity of the messenger systems in the altitude chamber hypoxia].
The activity of phosphoinositide and adenylate cyclase systems of second messengers in rat brain were investigated under altitude chamber treatment (6000 m x 24 hours). Selective suppression of each messenger system was achieved by pretreatment of rats with either lithium chloride or propranolol for 8 days. Consequences of this treatment and/or hypoxia were evaluated by orientation behavior and physical exercise test. Administration of LiCl caused reduction of phosphoinositide level; hypoxia (6000 m) caused further impairments in the second messenger content. The synergism between phosphoinositide and adenylatcyclase systems was demonstrated.
Vishnevskiĭ
A A
AA
Institute of High Altitude Physiology and Experimental Pathology, Kyrgyz Academy of Sciences, Gorkogo Str. 1/5, Bishkek, 720048 Kyrgyz Republic.
Iakovlev
V M
VM
Khabibullova
Z I
ZI
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000531:Altitude; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D000860:Hypoxia / Q000201:enzymology / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D015290:Second Messenger Systems / Q000502:physiology*
D000067956:Adenylyl Cyclase Inhibitors; D000319:Adrenergic beta-Antagonists; D010716:Phosphatidylinositols; D008094:Lithium; D011433:Propranolol; D000262:Adenylyl Cyclases