title: Antenatal necrotic injury in severe twin-to-twin transfusion syndrome. A case and review.
abstract: A case of twin-to-twin transfusion syndrome (TTTS) was associated with ischemic injury of the left leg of the recipient twin. Five reduction amniocenteses were performed between 17 6/7 and 23 3/7 weeks followed by fetoscopic laser ablation of chorioangiopagus vessels at 23 6/7 weeks of gestation. Anatomic assessment of the affected limb indicated timing of the injury at 19 4/7 weeks gestational age. The published literature suggests that ischemic fetal injuries in severe TTTS are associated with blood hyperviscosity in the affected twin.
authors.affiliation: Division of Maternal-Fetal Medicine, Women and Infants' Hospital and The Program in Fetal Medicine, Hasbro Children's Hospital and The Program in Fetal Medicine, Brown University, Providence, RI 02905, USA. SCarr@wihri.org
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Carr
authors.forename: François
authors.initials: F
authors.lastname: Luks
authors.forename: Thomas
authors.initials: T
authors.lastname: Tracy
authors.forename: Michael
authors.initials: M
authors.lastname: Plevyak
mesh_terms: D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005330:Fetofetal Transfusion / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007511:Ischemia / Q000150:complications / Q000175:diagnosis*; D007866:Leg / Q000098:blood supply* / Q000473:pathology*; D009336:Necrosis / Q000150:complications / Q000175:diagnosis; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000706:statistics & numerical data*