title: Copper(I) thiolate catalysts in asymmetric conjugate addition reactions.
abstract: [structure: see text] Full conversion and enantioselectivities up to 83% have been obtained in the conjugate addition reactions of diethyl zinc to Michael acceptors catalyzed by well-defined (chiral) copper(I) aminoarenethiolates. Interesting differences between organozinc or Grignard reagents have been found: for cyclic enones R(2)Zn reagents afford better results, whereas earlier work showed that RMgX reagents react more selectively with acyclic enones.
authors.affiliation: Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Arink
authors.forename: Thijs W
authors.initials: TW
authors.lastname: Braam
authors.forename: Roy
authors.initials: R
authors.lastname: Keeris
authors.forename: Johann T B H
authors.initials: JT
authors.lastname: Jastrzebski
authors.forename: Cyril
authors.initials: C
authors.lastname: Benhaim
authors.forename: Stéphane
authors.initials: S
authors.lastname: Rosset
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis
authors.forename: Gerard
authors.initials: G
authors.lastname: van Koten
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D017967:Zinc Compounds / Q000138:chemical synthesis*
chemical_list: D000438:Alcohols; D007659:Ketones; D009942:Organometallic Compounds; D017967:Zinc Compounds; C048402:copper(I)-thiolate