The impact of sildenafil on molecular science and sexual health.
OBJECTIVE
Sexual medicine has evolved greatly in the past several years, to a large extent because of the introduction of the phosphodiesterase-5 (PDE5) inhibitor, Viagra (sildenafil citrate), as a highly effective oral therapy for erectile dysfunction.


METHODS
Recent literature pertaining to the development and clinical applications of sildenafil citrate was reviewed.


RESULTS
The emergence of PDE5 inhibitor therapy for erectile dysfunction represents a major scientific and clinical breakthrough, and it has impacted on the field in such prominent areas as scientific discovery, clinical management, and public health awareness of sexual health disorders.


CONCLUSIONS
The development of sildenafil citrate has had a major role in advancing the field of sexual medicine.
Burnett
Arthur L
AL
Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, The Johns Hopkins Hospital, 600 North Wolfe Street, Marburg 407, Baltimore, MD 21287-2411, USA. aburnett@jhmi.edu
D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008967:Molecular Biology; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate