title: [Effect of ladasten on the proteinase C activity in the rat brain cells].
abstract: The effect of ladasten (50 mg/kg) on the activity of protein kinase C (PKC) in rat brain was studied depending on the duration of drug action. In the initial stage of the drug action, the PKC activity in the cytosol fraction of rat brain proteins exhibits a more than twofold increase. The effect is independent of the presence of exogenous Ca2+ and is inhibited by cinnarizine and nifedipine. The optimum Ca2+ concentration is maintained due to the activation of Ca2+ ATPase. It is concluded that the pharmacological activity of ladasten is related to activation of Ca2+ phospholipid-dependent protein kinases.
authors.affiliation: Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Vakhitova
authors.forename: M Kh
authors.initials: MKh
authors.lastname: Salimgareeva
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002118:Calcium / Q000378:metabolism; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D011619:Psychotropic Drugs; D011493:Protein Kinase C; D000218:Adamantane; D002118:Calcium