Hepatopulmonary syndrome: role of nitric oxide and clinical aspects.
Hepatopulmonary syndrome is defined by oxygenation impairment due to abnormal intrapulmonary vascular dilatations in patients with liver disease. The implication of enhanced pulmonary production of nitric oxide in the pathogenesis of intrapulmonary vascular dilatations has been demonstrated both in murine models and in human hepatopulmonary syndrome. The diagnosis of hepatopulmonary syndrome in chronic liver disease is of paramount importance, considering the fact that severe hypoxemia related to hepatopulmonary syndrome may occur in patients with well compensated liver disease and that survival is reduced in patients with hepatopulmonary syndrome relative to non hepatopulmonary syndrome patients. Priority for liver transplantation, which is presently the only cure, has been recently increased in patients with advanced hepatopulmonary syndrome.
Rolla
G
G
Allergology and Clinical Immunology, Department of Human Oncology, University of Torino, Mauriziano Umberto I Hospital, Largo Turati 62, Turin 10128, Italy. grolla@mauriziano.it
D000818:Animals; D020065:Hepatopulmonary Syndrome / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D016031:Liver Transplantation; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000097:blood; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011379:Prognosis
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase