Calcium sensing receptors as integrators of multiple metabolic signals.
Calcium sensing receptors are critical to maintenance of organismal Ca2+ homeostasis, translating small changes in serum Ca2+ into changes in PTH secretion by the parathyroid glands and Ca2+ excretion by the kidneys. Calcium sensing receptors are also expressed in many cells and tissues not directly involved in Ca2+ homeostasis where their role(s) are less defined. Recent studies have demonstrated that calcium sensing receptors integrate a variety of metabolic signals, including polyvalent cations, pH, ionic strength, amino acids, and polypeptides, making CaR uniquely capable of generating cell- and tissue-specific responses, sensing not only Ca2+, but the local metabolic environment. The challenge for future studies is to define CaR responsiveness in each varied physiological context.
Breitwieser
Gerda E
GE
Department of Biology, Syracuse University, 122 Lyman Hall, 108 College Place, Syracuse, NY 13244, USA. gebreitw@syr.edu
Miedlich
Susanne U
SU
Zhang
Mingliang
M
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001665:Binding Sites; D002412:Cations / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D005275:Fendiline / Q000737:chemistry / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009994:Osmolar Concentration; D010455:Peptides / Q000378:metabolism; D011073:Polyamines / Q000378:metabolism; D044169:Receptors, Calcium-Sensing / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D002412:Cations; D008024:Ligands; D010455:Peptides; D011073:Polyamines; D044169:Receptors, Calcium-Sensing; D005275:Fendiline