title: An update on choanal atresia surgery at Great Ormond Street Hospital for Children: preliminary results with Mitomycin C and the KTP laser.
abstract: We present the results of transnasal choanal atresia correction in 46 children, as an update to the published Great Ormond Street Hospital series. Females outnumbered males 2-1, and half the cases in our series were bilateral. Eight of the children with bilateral atresia had the CHARGE association. The median number of procedures required was three over a period of up to 3 years. Eighty-two percent of children with unilateral atresia and 78% of those with bilateral atresia were asymptomatic at the time of their last follow up. Four deaths occurred, all but one in children with CHARGE association. We were not able to demonstrate any benefit from the use of Mitomycin C, the KTP laser, betamethasone nasal drops or (in unilateral cases) stents.
authors.affiliation: Department of Paediatric Otolaryngology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK. haytham@ihr.gla.ac.uk
authors.forename: Haytham
authors.initials: H
authors.lastname: Kubba
authors.forename: Alex
authors.initials: A
authors.lastname: Bennett
authors.forename: C M
authors.initials: CM
authors.lastname: Bailey
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001623:Betamethasone / Q000627:therapeutic use; D002391:Catchment Area, Health; D002648:Child; D002754:Choanal Atresia / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery; D004739:England / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation* / Q000706:statistics & numerical data*; D007834:Lasers / Q000145:classification*; D008297:Male; D008937:Mitomycins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D008937:Mitomycins; C046000:mitomycin A; D001623:Betamethasone