title: Intraoperative optical imaging of human face cortical topography: a case study.
abstract: We used intrinsic signal optical imaging to obtain maps of human somatosensory cortex during electrocutaneous stimulation of the face during a neurosurgical procedure for epilepsy. We found that human face somatotopy is organized like the macaque or cebus monkey, with peri-orbital skin located medial to peri-buccal skin, and that cortical magnification in the human is comparable to that in non-human primates. This study demonstrates that intrinsic signal imaging can be performed on humans during operative procedures with sufficient spatial resolution to reveal high-resolution topographic maps.
authors.affiliation: Department of Neurosurgery,Yale University School of Medicine, New Haven, CT, USA. schwarh@med.cornell.edu
authors.forename: Theodore H
authors.initials: TH
authors.lastname: Schwartz
authors.forename: Li Min
authors.initials: LM
authors.lastname: Chen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Friedman
authors.forename: Dennis D
authors.initials: DD
authors.lastname: Spencer
authors.forename: Anna W
authors.initials: AW
authors.lastname: Roe
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D004827:Epilepsy / Q000601:surgery*; D005145:Face / Q000294:innervation*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D019635:Neurosurgical Procedures; D013003:Somatosensory Cortex / Q000502:physiology*