title: [Sensitization to inhalant and food allergens in Brazilian atopic children by in vitro total and specific IgE assay. Allergy Project--PROAL].
abstract: OBJECTIVE
  To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services.
  
  
  METHODS
  Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP - Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+).
  
  
  RESULTS
  Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated was higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow's milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens.
  
  
  CONCLUSIONS
  There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants.
authors.affiliation: Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
authors.forename: Charles K
authors.initials: CK
authors.lastname: Naspitz
authors.forename: Dirceu
authors.initials: D
authors.lastname: Solé
authors.forename: Cristina A
authors.initials: CA
authors.lastname: Jacob
authors.forename: Emanuel
authors.initials: E
authors.lastname: Sarinho
authors.forename: Francisco J P
authors.initials: FJ
authors.lastname: Soares
authors.forename: Vera
authors.initials: V
authors.lastname: Dantas
authors.forename: Márcia C
authors.initials: MC
authors.lastname: Mallozi
authors.forename: Neusa F
authors.initials: NF
authors.lastname: Wandalsen
authors.forename: Wellington
authors.initials: W
authors.lastname: Borges
authors.forename: Wilson
authors.initials: W
authors.lastname: Rocha Filho
mesh_terms: D017677:Age Distribution; D000485:Allergens / Q000032:analysis / Q000276:immunology*; D000818:Animals; D015415:Biomarkers; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005512:Food Hypersensitivity / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007223:Infant; D008297:Male; D008925:Mites; D011852:Radioallergosorbent Test / Q000379:methods; D012130:Respiratory Hypersensitivity / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D018709:Statistics, Nonparametric
chemical_list: D000485:Allergens; D015415:Biomarkers; D007073:Immunoglobulin E