title: Incidence and molecular typing of Mycobacterium kansasii in a defined geographical area in Catalonia, Spain.
abstract: A retrospective population-based study was conducted between January 1990 and December 1998 to investigate the incidence of Mycobacterium kansasji disease and the heterogeneity of the isolates in a well-defined geographical area in Catalonia, Spain. A total of 136 patients were identified. Overall incidence and incidence in AIDS patients was 1.5 (95% CI 1.2-1.8) and 1089.6 (95% CI 689-1330) cases/100,000 persons per year respectively, which is comparable to that reported from most of other geographical areas. Surprisingly, although 7 subtypes of M. kansasii have been consistently reported, in the present study 91 of the 93 isolates (97.8%) tested for genotype were subtype I, regardless of HIV status of the patients. In conclusion, the high rate of infection observed in the AIDS population contributes significantly to the burden of the M. kansasii disease in our area. M. kansasii disease in our geographical area was almost exclusively caused by subtype I regardless of HIV status.
authors.affiliation: Department of Infectious Diseases, Hospital Universitari de Bellvitge, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Santin
authors.forename: F
authors.initials: F
authors.lastname: Alcaide
authors.forename: M A
authors.initials: MA
authors.lastname: Benitez
authors.forename: A
authors.initials: A
authors.lastname: Salazar
authors.forename: C
authors.initials: C
authors.lastname: Ardanuy
authors.forename: D
authors.initials: D
authors.lastname: Podzamczer
authors.forename: G
authors.initials: G
authors.lastname: Rufi
authors.forename: J
authors.initials: J
authors.lastname: Dorca
authors.forename: R
authors.initials: R
authors.lastname: Martin
authors.forename: F
authors.initials: F
authors.lastname: Gudiol
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D016021:Epidemiologic Studies; D005260:Female; D005838:Genotype; D005843:Geography; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology*; D019909:Mycobacterium kansasii / Q000235:genetics* / Q000472:pathogenicity*; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology