title: Association analysis of the polymorphism T1128C in the signal peptide of neuropeptide Y in a Swedish hypertensive population.
abstract: OBJECTIVE
  The neuropeptide Y (NPY) signal peptide polymorphism T1128C has been linked to several risk factors for cardiovascular disease. The aim of the present study was to evaluate the significance of this polymorphism for cardiovascular and cerebrovascular disease outcome.
  
  
  METHODS
  In a prospective study cohort, 1032 hypertensive patients (174 myocardial infarction and 170 stroke patients and 688 matched controls) were analysed for the T1128C polymorphism in the NPY gene.
  
  
  METHODS
  The dynamic allele specific hybridization (DASH) method was used for genotyping. Serum from the same participants was analysed for total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides.
  
  
  RESULTS
  The frequency of the NPY T1128C polymorphism was 8.4% among patients with a myocardial infarction or stroke, as compared to 5.1% in the control group (P = 0.040). The difference remained significant after adjustment for the cardiovascular risk factors age, sex, smoking status, body mass index, systolic and diastolic blood pressure, presence of diabetes, total cholesterol, HDL, LDL and triglycerides.
  
  
  CONCLUSIONS
  The present study indicates that the NPY T1128C polymorphism is an independent predictor for myocardial infarction and stroke in a Swedish hypertensive population.
authors.affiliation: Department of Clinical Pharmacology, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden. susanna.wallerstedt@pharm.gu.se
authors.forename: Susanna M
authors.initials: SM
authors.lastname: Wallerstedt
authors.forename: Stanko
authors.initials: S
authors.lastname: Skrtic
authors.forename: Anna-Lena
authors.initials: AL
authors.lastname: Eriksson
authors.forename: Claes
authors.initials: C
authors.lastname: Ohlsson
authors.forename: Thomas
authors.initials: T
authors.lastname: Hedner
mesh_terms: D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D021382:Protein Sorting Signals / Q000235:genetics*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D013548:Sweden / Q000453:epidemiology
chemical_list: D009478:Neuropeptide Y; D021382:Protein Sorting Signals