title: Effect of age on mechanical properties of rat mesenteric small arteries.
abstract: With aging, large arteries become stiffer and systolic blood pressure consequently increases. Less is known, however, about the age-related change in mechanics of small resistance arteries. The aim of this study was to determine whether aging plays a role in the stiffening of the small mesenteric arteries of rats. Intra-arterial systolic, diastolic, mean and pulse pressures were measured in male Wistar rats aged 2, 4, 15 and 26 months. The passive mechanical properties of the wall of isolated perfused and pressurized arterial segments of mesenteric small arteries were also investigated. Intra-arterial systolic, diastolic and mean blood pressures tended to decrease with age and were significantly lower in the oldest rats (26-month-old group). Pulse pressure was significantly higher in the 15- and 26-month-old groups than in the two younger groups. Under isobaric conditions, increasing age is associated with an outward hypertrophic remodeling of the mesenteric arteries. Under relaxed conditions, incremental distensibility in response to increasing intravascular pressure did not change with aging. As a function of strain (under isometric conditions), stress shifted to the left as age increased, indicating an age-related vascular stiffening. Under isobaric conditions or in relation to wall stress, the elastic modulus was greater in the adult 15-month-old rats than in the younger rats. These findings suggest that distensibility seems to be preserved with aging, despite stiffness of the wall components, probably by arterial wall geometric adaptation, which limits the pulse pressure damage. It is interesting to note that elastic modulus in mesenteric arteries from the oldest rats (26-month-old), examined in relation to wall stress and intravascular pressure, did not differ from that of the youngest rats, thus suggesting that elasticity of wall components had been restored.
authors.affiliation: Laboratoire Physiologie Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Besançon, France. pascal.laurant@univ-fcomte.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Laurant
authors.forename: Mark
authors.initials: M
authors.lastname: Adrian
authors.forename: Alain
authors.initials: A
authors.lastname: Berthelot
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004548:Elasticity; D006339:Heart Rate / Q000502:physiology; D006984:Hypertrophy / Q000209:etiology; D008297:Male; D008638:Mesenteric Arteries / Q000033:anatomy & histology* / Q000473:pathology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology