[Familial Mediterranean fever in Mexico City. A 20-year follow-up].
Familial Mediterranean fever (MFF) is an autosomic recessive, inherited inflammatory disease principally seen in persons from the Mediterranean area. Clinical findings include fever, abdominal pain, and pleuritis. The most severe complication of MFF is renal amyloidosis, manifested as nephrotic syndrome, which evolves into chronic renal failure. In this study, we described clinical findings, evolution, and response to treatment in 52 patients diagnosed with MFF living in Mexico City in whom the most important clinical features were fever and abdominal pain. Differing from previous reported series of patients from the Mediterranean area, patient developed renal amyloidosis during the 20-year follow-up, which suggests that an environmental factor might have a significant influence in development of renal amyloidosis.
Halabe-Cherem
José
J
Departamento de Medicina Interna, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06725 México D.F., México.
Pérez-Jiménez
Carolina
C
Nellen-Hummel
Haiko
H
Mercado-Atri
Moisés
M
Sigala-Rodríguez
Carolina
C
Castañón-González
Jorge
J
D015746:Abdominal Pain / Q000209:etiology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000368:Aged; D028226:Amyloidosis, Familial / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications / Q000453:epidemiology* / Q000208:ethnology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000208:ethnology / Q000517:prevention & control; D007813:Laparotomy / Q000706:statistics & numerical data; D008297:Male; D008597:Menstrual Cycle; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications; D013593:Syria / Q000208:ethnology; D019564:Unnecessary Procedures
D003078:Colchicine