title: A short note on the nucleolar size and density in apoptotic leukemic granulocytic precursors (HL-60 cells).
abstract: The present study was undertaken to provide more information on the nucleolar size and density in mononuclear blastic granulocytic precursors represented by HL-60 cells the proliferation of which was blocked by photodynamic treatment (PDT) which induced apoptotic process without preceding terminal maturation. Both the nucleolar size and density did not change in apoptotic cells in comparison with controls. Thus, large and dense nucleoli in apoptotic cells are not necessarily related to the nucleolar biosynthetic or cell proliferation activity.
authors.affiliation: Institute of Hematology and Blood Transfusion, Prague, Czech Republic. karel.smetana@uhkt.cz
authors.forename: Karel
authors.initials: K
authors.lastname: Smetana
authors.forename: Pui K
authors.initials: PK
authors.lastname: Chan
authors.forename: Yuri
authors.initials: Y
authors.lastname: Marinov
authors.forename: Josef
authors.initials: J
authors.lastname: Soucek
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Hrkal
authors.forename: Harris
authors.initials: H
authors.lastname: Busch
mesh_terms: D000622:Aminolevulinic Acid / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002466:Cell Nucleolus / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D006098:Granulocytes / Q000187:drug effects / Q000473:pathology*; D018922:HL-60 Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008027:Light; D009697:Nucleolus Organizer Region / Q000737:chemistry / Q000187:drug effects; D017319:Photosensitizing Agents / Q000494:pharmacology; D016622:Silver Staining
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid