title: [Cardiac protection is a clinical evidence].
abstract: OBJECTIVE
  Anaesthetics may have protective effect against myocardial ischemia. We aimed to investigate if sevoflurane administration could exert myocardial protection during following coronary occlusion in patients with coronary artery disease.
  
  
  METHODS
  a).
  
  
  METHODS
  prospective, randomized study. b).
  
  
  METHODS
  University Hospital, cardiac surgical operative theatre. c).
  
  
  METHODS
  42 patients with coronary artery disease, scheduled to undergo coronary surgery.
  
  
  METHODS
  severe coronary stenosis of anterior descending coronary artery; no collateral flow on angiography; at least two normokinetic segments in the myocardial region supplied by the vessel being bypassed. PATIENTS were randomized to receive (group S) or not (group C) sevoflurane administration for 15 min just before coronary occlusion. d).
  
  
  METHODS
  Transoesophageal Tissue Doppler echocardiographic examination of myocardial systolic and early diastolic velocities in both groups basally and 60 s after coronary occlusion by the surgeon. e).
  
  
  METHODS
  systolic and early diastolic velocities were registered by Tissue Doppler from a long-axis view of the interventricular septum or the anterior wall of the left ventricle.
  
  
  RESULTS
  In group C a significant reduction of systolic and diastolic intramyocardial velocities was found during myocardial ischemia due to coronary occlusion.
  
  
  CONCLUSIONS
  Treatment with sevoflurane before coronary occlusion seem effective in reducing functional myocardial impairment due to ischemia.
authors.affiliation: U O C Anestesia e Rianimazione Cardiotoracica, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Guarracino
authors.forename: L
authors.initials: L
authors.lastname: Doroni
authors.forename: C
authors.initials: C
authors.lastname: Cariello
authors.forename: R
authors.initials: R
authors.lastname: Baldassarri
authors.forename: C
authors.initials: C
authors.lastname: Vullo
mesh_terms: D000368:Aged; D018685:Anesthetics, Inhalation / Q000627:therapeutic use*; D003327:Coronary Disease / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000627:therapeutic use*; D017202:Myocardial Ischemia / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane