Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins.
The toxicity to cells and animals of type 1 and toxic and non-toxic type 2 Ribosome-Inactivating Proteins (RIP) is discussed in correlation with their catalytic activity, resulting in ribosome inactivation and apoptosis. The symptoms and histopathological lesions induced by RIP to animals and humans is also reviewed.
Battelli
Maria Giulia
MG
Department of Experimental Pathology, Alma Mater Studiorum University of Bologna, Bologna, Italy. mgbatt@alma.unibo.it
D000276:Adjuvants, Immunologic; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D007125:Immunogenetics; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011506:Proteins / Q000235:genetics / Q000276:immunology / Q000633:toxicity*; D012270:Ribosomes / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D011506:Proteins