title: [Arrhythmia and left ventricle remodeling in acute myocardial infarct: recommendations for drug therapy].
abstract: Occurrences of arrhythmias during the acute myocardial infarction is explained with local ischaemia, but mechanism of later occurrences is unclear. Our study had for the aim to examine relationship between postinfarction left ventricle dilatation and appearance of arrhythhmias, and to show drug effects on remodelling. Patients who developed progressive left ventricle dilatation had higher mortality then patients without changes of left ventricle volume, and mortality is due of sudden cardiac death. Drugs who had preventive effects or reverse remodelling can help in prevention of malignant arrhythhmias and sudden cardiac death. It is showed that ACE inhibitors, beta-blockers and aldosterone antagonists had preventive effects on left ventricle remodelling. The combined therapy with ACE inhibitors, beta-blockers and aldosterone antagonists is showed as the most-effective in prevention of remodelling, appearaance of arrhythhmias and sudden cardiac death.
authors.affiliation: Interna klinika, JZU UKC Tuzla.
authors.forename: Zumreta
authors.initials: Z
authors.lastname: Kusljugić
authors.forename: Katarina
authors.initials: K
authors.lastname: Divković
authors.forename: Fahir
authors.initials: F
authors.lastname: Braković
authors.forename: Elnur
authors.initials: E
authors.lastname: Smajić
authors.forename: Marko
authors.initials: M
authors.lastname: Buksa
authors.forename: Mirsada
authors.initials: M
authors.lastname: Praso
authors.forename: Hajra
authors.initials: H
authors.lastname: Boskailo
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D004359:Drug Therapy, Combination; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000517:prevention & control; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000150:complications* / Q000503:physiopathology; D020257:Ventricular Remodeling / Q000187:drug effects*
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000451:Mineralocorticoid Receptor Antagonists