title: Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh.
abstract: The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence of Vibrio cholerae O139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic setting. Although a higher baseline vibriocidal titer correlated with protection from V. cholerae O1, infection still developed in some contacts with very high titers. No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection.
authors.affiliation: International Centre for Diarrheal Disease Research, Bangladesh.
authors.forename: Debasish
authors.initials: D
authors.lastname: Saha
authors.forename: Regina C
authors.initials: RC
authors.lastname: LaRocque
authors.forename: Ashraful I
authors.initials: AI
authors.lastname: Khan
authors.forename: Jason B
authors.initials: JB
authors.lastname: Harris
authors.forename: Yasmin Ara
authors.initials: YA
authors.lastname: Begum
authors.forename: Syed M
authors.initials: SM
authors.lastname: Akramuzzaman
authors.forename: Abu S G
authors.initials: AS
authors.lastname: Faruque
authors.forename: Edward T
authors.initials: ET
authors.lastname: Ryan
authors.forename: Firdausi
authors.initials: F
authors.lastname: Qadri
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Calderwood
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001459:Bangladesh / Q000453:epidemiology; D002771:Cholera / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D014505:Urban Population; D041241:Vibrio cholerae O1 / Q000276:immunology*; D041242:Vibrio cholerae O139 / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial