[A study on the inhibiting effects of transforming growth factor-beta R II antibody on fibroblasts].
OBJECTIVE
To investigate the inhibiting action of transforming growth factor-beta type R II receptor(TGF-beta R II) antibody to fibroblasts.


METHODS
Four groups of cultured skin fibroblasts were treated with different dosages of TGF-beta R II antibody. Examinations were performed with HYP, MTT, microscope, and flow cytometry techniques.


RESULTS
TGF-beta R II antibody resulted in significant inhibition of fibroblasts(P < 0.01).


CONCLUSIONS
TGF-beta R II antibody has inhibiting effects on the proliferation of skin fibroblasts and with a dose-dependent manner.
Quan
Yu-zhu
YZ
Plastic Surgery Hospital of Chinese Academy of Medical Sciences, Beijing 100041, China.
Zhuang
Hong-xing
HX
Zhang
Qing-guo
QG
Leng
Yong-cheng
YC
Hang
Juan
J
Zhao
Yan-yong
YY
D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D005434:Flow Cytometry; D006801:Humans; D008854:Microscopy, Electron; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II