Allometric analysis of ciprofloxacin and enrofloxacin pharmacokinetics across species.
The purpose of this study was to examine the allometric analysis of ciprofloxacin and enrofloxacin using pharmacokinetic data from the literature. The pharmacokinetic parameters used were half-life, clearance and volume of distribution. Relationships between body weight and the pharmacokinetic parameter were based on the empirical formula Y = aW(b), where Y is half-life, clearance or volume of distribution, W the body weight and a is an allometric coefficient (intercept) that is constant for a given drug. The exponential term b is a proportionality constant that describes the relationship between the pharmacokinetic parameter of interest and body weight. A total of 21 different species of animals were studied. Results of the allometric analyses indicated similarity between clearance and volume of distribution as they related to body weight for both drugs. Results of the current analyses indicate it is possible to use allometry to predict pharmacokinetic variables of enrofloxacin or ciprofloxacin based on body size of species. This could provide information on appropriate doses of ciprofloxacin and enrofloxacin for all species.
Cox
S K
SK
Department of Comparative Medicine, University of Tennessee, Knoxville, TN 37996, USA. scox6@utk.edu
Cottrell
M B
MB
Smith
L
L
Papich
M G
MG
Frazier
D L
DL
Bartges
J
J
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D000077422:Enrofloxacin; D024841:Fluoroquinolones / Q000493:pharmacokinetics*; D006801:Humans; D008954:Models, Biological; D015363:Quinolones / Q000493:pharmacokinetics*; D013045:Species Specificity; D019155:Veterinary Drugs / Q000493:pharmacokinetics
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D019155:Veterinary Drugs; D000077422:Enrofloxacin; D002939:Ciprofloxacin