Roller compaction of crude plant material: influence of process variables, polyvinylpyrrolidone, and co-milling.
Roller compaction of a milled botanical (Baphicacanthus cusia) with and without a binder, polyvinylpyrrolidone (PVP) was conducted. Effects of co-milling on binder function and flowability of the powder blend was also investigated. Flakes were comminuted, and the size and size distribution, friability, Hausner ratio, and Carr index of the granulations were determined. Crude herb should be reduced to a suitable size for it to be successfully roller compacted. Larger-sized and less friable granules were obtained with decreasing roller speed. Addition of PVP affected the flowability and binding capacity of the herbal powder blend, which influenced size and friability of the granules. Co-milling of PVP with the herbal powder enhanced the flow of the blends and the effectiveness of the binder, which contributed favorably to the roller-compacted product. Roller compaction is a convenient and cost-effective granulating technique suitable for milled botanicals. Co-milling can be used to improve the properties of roller-compacted products.
Heng
P W S
PW
Department of Pharmacy, National University of Singapore, Singapore. phapaulh@nus.edu.sg
Chan
L W
LW
Liew
C V
CV
Chee
S N
SN
Soh
J L P
JL
Ooi
S M
SM
D029062:Apocynaceae / Q000737:chemistry; D010316:Particle Size; D010592:Pharmaceutic Aids / Q000737:chemistry*; D028321:Plant Preparations / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D011208:Powders; D013678:Technology, Pharmaceutical / Q000295:instrumentation*
D010592:Pharmaceutic Aids; D028321:Plant Preparations; D011208:Powders; D011205:Povidone