title: Antifouling activity of simple synthetic isocyanides against larvae of the barnacle Balanus amphitrite.
abstract: Twelve simple linear isocyanides were synthesized and examined for antifouling activity and toxicity against cyprid larvae of the barnacle, Balanus amphitrite. Larval settlement was inhibited, with EC50 values of 0.046-1.90 microg ml(-1), and they were much less toxic (LD50 values ranging over 21.28 microg ml(-1)) than CuSO4 (EC50 0.30 microg ml(-1) and LD50 2.95 microg ml(-1)). The data indicate that simple linear isocyanides are promising non-toxic antifouling agents.
authors.affiliation: Abiko Research Laboratory Central Research Institute of Electric Power Industry 1646 Abiko Abiko-shi Chiba-ken 270-1194 Japan. noga@criepi.denken.or.jp
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Nogata
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kitano
authors.forename: Erina
authors.initials: E
authors.lastname: Yoshimura
authors.forename: Kyouji
authors.initials: K
authors.lastname: Shinshima
authors.forename: Isamu
authors.initials: I
authors.lastname: Sakaguchi
mesh_terms: D000818:Animals; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D007814:Larva / Q000187:drug effects; D008386:Marine Biology; D013329:Structure-Activity Relationship; D001468:Thoracica / Q000187:drug effects* / Q000254:growth & development
chemical_list: D003486:Cyanides