Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus.
This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subfraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subfraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity.
Kim
Sun-Hyoung
SH
College of Pharmacy, Sookmyung Women's University, Cheongpa-dong, Yongsan, Seoul 140-742, South Korea.
Song
Yun-Seon
YS
Kim
Seung-Kook
SK
Kim
Byung-Chul
BC
Lim
Chang-Jin
CJ
Park
Eun-Hee
EH
D000363:Agaricales; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000627:therapeutic use*; D000440:Butanols / Q000302:isolation & purification / Q000627:therapeutic use*; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000440:Butanols; D010936:Plant Extracts