[Effect of static magnetic field on development toxicity of rat embryonic midbrain neurons cells].
OBJECTIVE
To explore the effect of static magnetic field (SMF) on the differentiation and proliferation of rat embryonic midbrain neurons cells.


METHODS
The micromass culture of rat embryonic midbrain neurons cell was applied to study the effect of varieties of SMF (1.0, 10.0, 50.0, 100.0, 200.0 mT) and FACS.


RESULTS
SMF inhibited the differentiation of the cell without affecting cell proliferation. The concentration of 50% inhibition of cell differentiation (ICD(50)) was 25 mT. The concentration of 50% inhibition of cell differentiation (IVD(50)) was 45 mT.


CONCLUSIONS
The inhibition of SMF on embryonic midbrain neurons cells may be associated with impact of protein syntheses, and lipid peroxidation.
Duan
Li-rong
LR
Department of Hygiene, School of Medicine Jiangsu University, Zhenjiang 212001.
Wu
Quan-yi
QY
Liu
Fang-ping
FP
D000818:Animals; D002454:Cell Differentiation / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D002478:Cells, Cultured; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004622:Embryo, Mammalian; D005260:Female; D015227:Lipid Peroxidation / Q000528:radiation effects; D008636:Mesencephalon / Q000166:cytology / Q000528:radiation effects*; D009474:Neurons / Q000166:cytology / Q000528:radiation effects; D014176:Protein Biosynthesis / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley