title: [Long-term clinical observation of infants with gastroesophageal reflux].
abstract: The aim of the study was long-term observation of patients with gastroesophageal reflux (GER), diagnosed in their infancy, in aspect of spontaneous resolution of this disorder. 290 symptomatic infants aged 5 weeks to 11 months (mean--5.8 months) underwent 24-hour esophageal pH monitoring. In 243 (83.8%) patients, abnormal reflux score was observed. After one year of conservative therapy, follow-up study by esophageal pH-monitoring has been performed in 136 (46.9%) children and still showed pathological GER in 95 (69.8%) subjects. After 2 years, 45 (15.5%) patients has been investigated--14/45 (31.0%) of them had normal reflux score. At the following five-year clinical observation was available group of 28/290 (9.6%) patients. In the 2-3 year of their life, 13 of them had resolved symptoms and had normal acid reflux parameters, whereas 9 patients still had pathological GER. In the following years, basing of results of 24-hour pH monitoring, pathological GER persisted: in 7 children in age 4, in 5 subjects in age 5 and in 3 children over fifth year of life. Long-term clinical follow-up of these children is necessary because of risk of GER complications.
authors.affiliation: III Klinika Chorób Dzieci Akademii Medycznej w Białymstoku, Samodzielny Publiczny Szpital Kliniczny w Białymstoku.
authors.forename: Janusz
authors.initials: J
authors.lastname: Semeniuk
authors.forename: Maciej
authors.initials: M
authors.lastname: Kaczmarski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Sidor
authors.forename: Aleksander
authors.initials: A
authors.lastname: Krasnow
authors.forename: Urszula
authors.initials: U
authors.lastname: Daniluk
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Matuszewska
mesh_terms: D005260:Female; D005500:Follow-Up Studies; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic; D013997:Time Factors