title: [Viral hepatitis in users of addictive drugs in the Czech Republic].
abstract: BACKGROUND
  Prevalence of viral hepatitis A-C markers in problematic drug users was studied.
  
  
  METHODS
  Two groups of drug users, i.e. addicts enrolled in a mid-term drug withdrawal community program (group 1) and penitentiary prisoners (group 2), were tested for the presence of viral hepatitis A-C markers. Group 1 of 546 addicts (335 males and 211 females) included 163 male and 91 female injection drug users (IDUs) and 172 male and 120 female mostly alcohol abusers. Group 2 of 197 male prisoners included 150 injection drug users and 47 mostly alcohol abusers. Serological markers of viral hepatitis were detected by EIA within the entry check-up; RT PCR was used for detection of HCV nucleic acid.
  
  
  RESULTS
  The prevalence rates of anti-HAV antibodies among group 1 addicts were 33.6% for IDUs and 39.5% for the remaining mostly alcohol abusers. HBsAg was found in 4.2% of IDUs and 0.0% in the remaining addicts. Two IDUs also tested positive for HBeAg. Anti-HCV positivity was recorded in 22.4% of IDUs and 5.6% of the remaining addicts. The prevalence rates of anti-HAV antibodies among group 2 penitentiary prisoners were 40.7% for IDUs and 28.6% for the remaining mostly alcohol abusers. Anti-HAV IgM antibodies were detected in 4.2% prisoner IDUs. HBsAg was found in 3.4% of IDUs and 6.5% in the remaining addicts. Anti-HCV positivity was recorded in 18.1% of IDUs and 16.3% of the remaining addicts.
  
  
  CONCLUSIONS
  The prevalence rates of the markers studied in the addicts are several times as high as in the general population; therefore, the population of addicts is a potential source of the spread of viral hepatitis.
authors.affiliation: Farmaceutická fakulta UK, Hradec Králové.
authors.forename: H
authors.initials: H
authors.lastname: Klusonová
authors.forename: V
authors.initials: V
authors.lastname: Stĕpánová
authors.forename: J
authors.initials: J
authors.lastname: Cízek
authors.forename: L
authors.initials: L
authors.lastname: Plísková
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000534:rehabilitation / Q000821:virology*; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D008297:Male; D008875:Middle Aged; D011329:Prisoners; D016036:Seroepidemiologic Studies; D016320:Substance Abuse Treatment Centers; D015819:Substance Abuse, Intravenous / Q000534:rehabilitation / Q000821:virology*