Haemophilus influenzae type b immunization in adults infected with the human immunodeficiency virus.
The purpose of this study was to assess the influence of Haemophilus influenzae type b conjugate vaccine on HIV-1 RNA level, CD4 count, and anti-Hib polysaccharide (PRP) antibody concentration. Eighty HIV-infected adults were randomized to receive Hib conjugate vaccine or not. Twenty HIV-seronegative controls were also vaccinated. Blood samples were taken before and after vaccination, with a follow-up period of 6 months. HIV infection markers and anti-PRP antibodies were monitored. There was no change in either HIV-1 viremia or CD4 count after vaccination. Immunization immunogenicity was superior in HIV-uninfected than in HIV-infected individuals (p < 0.01). Hib vaccination was safe but induced suboptimal antibody response in HIV-infected adults.
De Sousa dos Santos
Sigrid
S
Department of Infectious and Parasitic Diseases, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil. ssigrid@hotmail.com
Lopes
Marta Heloísa
MH
Simonsen
Vera
V
Caiaffa Filho
Hélio Hehl
HH
D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D019562:Viral Load
D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines