title: Pseudo-precocious puberty caused by a juvenile granulosa cell tumour secreting androstenedione, inhibin and insulin-like growth factor-I.
abstract: We report a female child who presented at age 3.92 years with a 2-year history of consonant pubertal development caused by a large right-sided ovarian juvenile granulosa cell tumour (JGCT). Although JGCTs causing pseudo-precocious puberty have been previously described, they remain rare and endocrine data are often incomplete. In this case the tumour was associated with raised serum oestradiol, androstenedione, inhibin and IGF-I. Histological changes were consistent with JGCT. Immunohistochemical studies revealed positive reactivity to MIC-2, inhibin, melan A, IGF-I and IGFBP-2.
authors.affiliation: Department of Paediatric Endocrinology, St Bartholomew's and The Royal London School of Medicine and Dentistry, London, UK.
authors.forename: L F
authors.initials: LF
authors.lastname: Chan
authors.forename: H L
authors.initials: HL
authors.lastname: Storr
authors.forename: I
authors.initials: I
authors.lastname: Scheimberg
authors.forename: L A
authors.initials: LA
authors.lastname: Perry
authors.forename: K
authors.initials: K
authors.lastname: Banerjee
authors.forename: F
authors.initials: F
authors.lastname: Miraki-Moud
authors.forename: C
authors.initials: C
authors.lastname: Camacho-Hübner
authors.forename: M O
authors.initials: MO
authors.lastname: Savage
mesh_terms: D000735:Androstenedione / Q000378:metabolism*; D002675:Child, Preschool; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D011629:Puberty, Precocious / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000735:Androstenedione; D007265:Inhibins; D007334:Insulin-Like Growth Factor I