Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents.
Ten new beta-D-ribofuranosyl and 2'-beta-C-methyl-beta-D-ribofuranosyl triciribine derivatives 4-13 with various N4 and 6-N substituents on the tricyclic ring were synthesized from the corresponding toyocamycin and new 2'-beta-C-methyl toyocamycin derivatives. The inhibitory studies of these compounds in the HCV replicon assay reveal that some of them possess interesting anti-HCV properties with low cytotoxicity.
Smith
Kenneth L
KL
Valeant Pharmaceuticals International, 3300 Hyland Avenue, Costa Mesa, CA 92626, USA.
Lai
Vicky C H
VC
Prigaro
Brett J
BJ
Ding
Yili
Y
Gunic
Esmir
E
Girardet
Jean-Luc
JL
Zhong
Weidong
W
Hong
Zhi
Z
Lang
Stanley
S
An
Haoyun
H
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D015394:Molecular Structure; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D012263:Ribonucleosides; C023764:triciribine