title: Synthesis of aldehydo-sugar derivatives of pyrazoloquinoline as inhibitors of herpes simplex virus type 1 replication.
abstract: Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt.
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Bekhit
authors.forename: Ola A
authors.initials: OA
authors.lastname: El-Sayed
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
authors.forename: Yunus M
authors.initials: YM
authors.lastname: Siddiqui
authors.forename: Mohammed N
authors.initials: MN
authors.lastname: Al-Ahdal
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002241:Carbohydrates / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005840:Gentian Violet; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013194:Staining and Labeling; D013329:Structure-Activity Relationship; D023382:Toxicity Tests, Acute; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000447:Aldehydes; D000998:Antiviral Agents; D002241:Carbohydrates; D011720:Pyrazoles; D011804:Quinolines; D005840:Gentian Violet