title: Metastatic neuroblastoma presenting with binocular blindness from intracranial compression of the optic nerves.
abstract: A 2-year-old boy with blindness as an isolated symptom was found to have no light perception binocularly because of compression of both optic nerves by a neuroblastoma infiltrating the walls of the optic canals and medial sphenoid bone. Imaging disclosed a primary tumor near the kidney and multiple osseous metastases. Although neuroblastoma commonly causes blindness by metastasis to the orbit, it rarely causes bilateral blindness from intracranial compression of the optic nerves. This is the first report of bilateral blindness as the presenting feature.
authors.affiliation: Department of Ophthalmology (Kellogg Eye Center), University of Michigan Medical School, Ann Arbor, Michigan 48105, USA.
authors.forename: Juan J Chan
authors.initials: JJ
authors.lastname: Lau
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Trobe
authors.forename: Robert E
authors.initials: RE
authors.lastname: Ruiz
authors.forename: Robert W
authors.initials: RW
authors.lastname: Cho
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Wechsler
authors.forename: Gaurang V
authors.initials: GV
authors.lastname: Shah
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Gebarski
mesh_terms: D001766:Blindness / Q000209:etiology* / Q000503:physiopathology; D002675:Child, Preschool; D003131:Combined Modality Therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009408:Nerve Compression Syndromes / Q000150:complications / Q000209:etiology*; D009447:Neuroblastoma / Q000150:complications* / Q000175:diagnosis / Q000556:secondary* / Q000601:surgery / Q000628:therapy; D009901:Optic Nerve Diseases / Q000150:complications / Q000209:etiology*; D012074:Remission Induction; D012888:Skull Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D013100:Sphenoid Bone; D015348:Vision, Binocular; D014792:Visual Acuity