Mycophenolate mofetil attenuates Walker's tumor growth when used alone, but the effect is lost when associated with cyclosporine.
OBJECTIVE
To investigate the effect of mycophenolate mofetil on Walker's carcinosarcoma, without versus with the growth and regression of cyclosporine.


RESULTS
Wistar rats received water (control), MMF, and/or CsA-N 1 day before tumor inoculation. On day 10, tumor volume (TV) was lower among MMF (10.3 +/- 2.8 cm(3)) than control rats (14.9 +/- 4.2 cm(3), P <.05), and similar to that in CsA-N (13.9 +/- 3.0 cm(3)). However, tumor weight (TW) was significantly lower in MMF (5.2 +/- 2.0 g) than CsA-N (8.8 +/- 2.1g) or control hosts (7.3 +/- 2.0 g, P < or =.01). Growth was inhibited by MMF (-28.2%). In experiment II, CsA-N, MMF + CsA-N, or water were introduced 1 day before tumor inoculation. On day 10, TV and TW were similar for MMF + CsA-N as compared to CsA-N and control animals. In experiment III, water or MMF was introduced on the day 4 after tumor inoculation. On day 10, tumor growth are TW in the MMF group was similar to, that in the controls.


CONCLUSIONS
MMF produces an anti-tumoral effect against Walker's carcinosarcoma. However, this inhibitory effect was lost when MMF was used in combination with CsA-N or administered in the presence of a well- established tumor.
Silva
S L
SL
Renal Transplant Unit, Medical School, Ceará Federal University, Fortaleza-Ceará, Brazil. sonials@baydenet.com.br
Silva
S F R
SF
Cavalcante
R O
RO
Mota
R S
RS
Carvalho
R A
RA
Moraes
M O
MO
Campos
H H
HH
Moraes
M E A
ME
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D016572:Cyclosporine / Q000627:therapeutic use; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid