title: Identification of a novel HLA-DRB1 allele (DRB1*1147)* by sequence-based typing in eight siblings.
abstract: We report here a novel DRB1 allele (DRB1*1147) identified by sequence-based typing. The DRB1*1147 allele was detected during routine human leukocyte antigen (HLA)-typing of a patient and his family prior to bone marrow transplantation. This allele was found in the patient and his two sisters and five brothers. The new allele is identical to DRB1*110601 at exon 2 except for a single-nucleotide substitution at codon 37 (TAC-->TCC), changing the encoded tyrosine to serine.
authors.affiliation: Guangzhou Cord Blood Bank, Guangzhou Maternal and Neonatal Hospital, Guangzhou, China. firefly@21cn.com
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Liao
authors.forename: X
authors.initials: X
authors.lastname: Yang
authors.forename: X-W
authors.initials: XW
authors.lastname: Tang
authors.forename: J-Y
authors.initials: JY
authors.lastname: Wu
authors.forename: Y-N
authors.initials: YN
authors.lastname: Huang
authors.forename: X-M
authors.initials: XM
authors.lastname: Xie
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D012689:Sequence Homology, Nucleic Acid; D035781:Siblings
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D004247:DNA