Cytotoxic natural products from Formosan plants and marine organisms.
Cytotoxic natural products isolated from Formosan plants and marine organisms till December, 2002, by local scientists or Taiwanese researchers have been reviewed. A total of about 200 compounds belonging to six types of chemical structures are listed or/and described in this article. Several compounds with special or selective activity have been described in more details. Some structure-activity relationships for the compounds of the same skeleton are drawn to clarify the possible pharmacophores.
Lee
Shoei-Sheng
SS
School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan, Republic of China. shoeilee@ha.mc.ntu.edu.tw
Chang
Wen-Liang
WL
D000818:Animals; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry* / Q000145:classification; D013329:Structure-Activity Relationship; D013624:Taiwan; D013997:Time Factors
D001688:Biological Products; D003603:Cytotoxins