Gradual recovery from dyslexia and related serial magnetoencephalographic changes in the lexicosemantic centers after resection of a mesial temporal astrocytoma. Case report.
Letter-perception centers are not held in as high regard as motor- and language-related cortices during planning of neurosurgical procedures, and there have been no reports suggesting cortical reorganization of reading ability. The authors describe a patient with a left mesial temporal glioma in whom two letter-perception centers (the anterior portion of the left superior temporal gyrus and the left fusiform gyrus) were successfully localized before surgery by performing magnetoencephalography (MEG) during reading tasks. Control MEG examinations of 15 healthy volunteers were also performed to assist in a careful interpretation of patient results. Although a radical resection of the mesial temporal glioma, which involved the left fusiform gyrus, caused severe dyslexia, the patient's impaired reading skills improved gradually during a 1-year postoperative period. In the meantime, the spared left superior temporal gyrus displayed an overshot recovery of MEG responses. During the postoperative period there was no obvious recovery in MEG signals and no compensatory activity in the contralateral fusiform gyrus. This case demonstrates that lexicosemantic centers involved in the reading process can be noninvasively localized using MEG and that the results obtained are highly reliable for surgical planning. The results of the repeated MEG reflected sequentially the patient's recovery from dyslexia. This is the first report in which MEG studies have been shown to predict preoperatively the risk of dyslexia and demonstrate its serial physiological recovery.
Kamada
Kyousuke
K
Department of Neurosurgery, Research Institute for Electronic Science, Hokkaido University, Japan. kamady-k@umin.ac.jp
Sawamura
Yutaka
Y
Takeuchi
Fumiya
F
Houkin
Kiyohiro
K
Kawaguchi
Hideaki
H
Iwasaki
Yoshinobu
Y
Kuriki
Shinya
S
D000328:Adult; D001254:Astrocytoma / Q000150:complications* / Q000601:surgery*; D001932:Brain Neoplasms / Q000150:complications* / Q000601:surgery*; D016022:Case-Control Studies; D004410:Dyslexia / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D013702:Temporal Lobe / Q000473:pathology*; D016896:Treatment Outcome