title: Cytomegalovirus (CMV)-specific cellular immune responses.
abstract: A large percentage of healthy individuals (50-90%) is chronically infected with Cytomegalovirus (CMV). Over the past few years, several techniques were developed in order to monitor CMV-specific T-cell responses. In addition to the identification of antigen-specific T cells with peptide-loaded MHC complexes, most of the current strategies to identify CMV-specific T cells are centered on the assessment of the functions of memory T cells including their ability to mediate effector function, to proliferate or to secrete cytokines following antigen-specific stimulation. The investigation of these functions has allowed the characterization of the CMV-specific T-cell responses that are present during different phases of the infection. Furthermore, it has also been shown that the combination of virus-specific CD4 and CD8 T-cell responses are critical components of the immune response in the control of virus replication.
authors.affiliation: Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Harari
authors.forename: Simone C
authors.initials: SC
authors.lastname: Zimmerli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pantaleo
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000276:immunology*; D005434:Flow Cytometry / Q000379:methods; D015497:HIV-1 / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007157:Immunologic Surveillance / Q000276:immunology; D007371:Interferon-gamma / Q000378:metabolism; D015166:Monitoring, Immunologic / Q000379:methods; D010750:Phosphoproteins / Q000276:immunology; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000032:analysis; D014180:Transplantation / Q000009:adverse effects; D014763:Viral Matrix Proteins / Q000276:immunology
chemical_list: C515370:CCR7 protein, human; D015395:Histocompatibility Antigens Class I; D010750:Phosphoproteins; D054400:Receptors, CCR7; D019707:Receptors, Chemokine; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa; D007371:Interferon-gamma