Gestational carrier is an optimal method for pregnancy in patients with vaginal agenesis (Rokitansky syndrome).
OBJECTIVE
To evaluate the results of successful pregnancy for patients with Mayer-Rokitansky-Kuster-Hauser syndrome using a gestational carrier.


METHODS
All gestational carrier patients who attended our infertility clinic between 1995 and 2002 were reviewed for this study. Of the patients, 6 women with MRKH syndrome had 12 ovarian stimulation cycles, which resulted in 12 fresh and 5 frozen embryo transfers into six gestational carriers.


RESULTS
The mean number (+/-SD) of embryos obtained per cycle was 4.8 (+/-2.9). Either two (n = 15) or three (n = 2) embryos were transferred to the gestational carrier. Three pregnancies were achieved following fresh embryo transfer, which included one clinical pregnancy that ended in spontaneous abortion, a singleton, and a set of twins. The pregnancy rate for fresh embryo transfer was 25% per retrieval and 50% per patient. No pregnancy was achieved following frozen embryo transfer.


CONCLUSIONS
Gestational carrier is shown to be an effective treatment for patients with Mayer-Rokitansky-Kuster-Hauser syndrome.
Esfandiari
Navid
N
Toronto Centre for Advanced Reproductive Technology, Toronto, Canada. nesfand@excite.com
Claessens
E Anne
EA
O'Brien
Anne
A
Gotlieb
Lynda
L
Casper
Robert F
RF
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009864:Ontario; D011247:Pregnancy; D011256:Pregnancy Outcome; D013533:Gestational Carriers; D013997:Time Factors; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities*