Enhancement of feeding suppression by PYY(3-36) in rats with area postrema ablations.
We investigated suppression of food intake by intraperitoneal (IP) injections of peptide YY(3-36) (PYY(3-36)) (24, 60, or 150 microg/kg) in rats with ablations of the area postrema (APX) and in controls with sham ablations. In controls, PYY(3-36)-induced suppression was modest and short-lived, averaging 20% at most and persisting less than 6h. The highest dose tested (150 microg/kg) was even less effective than were the two lesser doses after 3h. APX did not diminish the potency of these effects of PYY(3-36). In fact, the magnitude of suppression produced by the greatest dose of PYY(3-36) in APX rats was significantly greater than in controls and PYY(3-36)-induced suppression was still present at 24h.
Cox
James E
JE
Department of Psychology, University of Alabama at Birmingham, 415 Campbell Hall, Birmingham, AL 35294-1170, USA. jecox@uab.edu
Randich
Alan
A
D000818:Animals; D031608:Area Postrema / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments; D019894:Peptide YY / Q000494:pharmacology*; D051381:Rats
D010446:Peptide Fragments; D019894:Peptide YY; C061785:peptide YY (3-36)