title: Surface normal overlap: a computer-aided detection algorithm with application to colonic polyps and lung nodules in helical CT.
abstract: We developed a novel computer-aided detection (CAD) algorithm called the surface normal overlap method that we applied to colonic polyp detection and lung nodule detection in helical computed tomography (CT) images. We demonstrate some of the theoretical aspects of this algorithm using a statistical shape model. The algorithm was then optimized on simulated CT data and evaluated using a per-lesion cross-validation on 8 CT colonography datasets and on 8 chest CT datasets. It is able to achieve 100% sensitivity for colonic polyps 10 mm and larger at 7.0 false positives (FPs)/dataset and 90% sensitivity for solid lung nodules 6 mm and larger at 5.6 FP/dataset.
authors.affiliation: Department of Radiology, Stanford University, Stanford, CA 94305-5450, USA. paik@smi.stanford.edu
authors.forename: David S
authors.initials: DS
authors.lastname: Paik
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Beaulieu
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Rubin
authors.forename: Burak
authors.initials: B
authors.lastname: Acar
authors.forename: R Brooke
authors.initials: RB
authors.lastname: Jeffrey
authors.forename: Judy
authors.initials: J
authors.lastname: Yee
authors.forename: Joyoni
authors.initials: J
authors.lastname: Dey
authors.forename: Sandy
authors.initials: S
authors.lastname: Napel
mesh_terms: D000465:Algorithms; D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D016208:Databases, Factual; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D036542:Tomography, Spiral Computed / Q000379:methods*