Synthesis and antibacterial activity of novel bifunctional macrolides.
We report the discovery of a novel class of macrolide antibiotics that have improved antibacterial activity against Ery-resistant organisms.
Akritopoulou-Zanze
Irini
I
Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA.
Phelan
Kathleen M
KM
Marron
Thomas G
TG
Yong
Hong
H
Ma
Zhenkun
Z
Stone
Greg G
GG
Daly
Melissa M
MM
Hensey
Dena M
DM
Nilius
Angela M
AM
Djuric
Stevan W
SW
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004351:Drug Resistance; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D018942:Macrolides; D004917:Erythromycin