Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers.
Recent studies have indicated that the most important role of beta-amyloid peptide (Abeta) in the etiology of Alzheimer's disease may not be in plaque formation but in the formation of soluble, metastable Abeta(1-42) neurotoxic intermediates (called ADDLs). In the present work we describe the preparation of per-6-amino-6-deoxy-beta-cyclodextrins, which inhibit ADDLs formation in vitro.
Wang
Zhiqiang
Z
Chang
Lei
L
Klein
William L
WL
Thatcher
Gregory R J
GR
Venton
Duane L
DL
D016229:Amyloid beta-Peptides / Q000737:chemistry*; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry; D009842:Oligopeptides / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D012995:Solubility; D013329:Structure-Activity Relationship
D016229:Amyloid beta-Peptides; D003505:Cyclodextrins; D009842:Oligopeptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)