title: Retroperitoneal malignant peripheral nerve sheath tumor: evaluation with serial FDG-PET.
abstract: Retroperitoneal malignant peripheral nerve sheath tumor (MPNST), a rare type of neurogenic tumor, was diagnosed in a 14-year-old girl with a history of neurofibromatosis type 1 (NF1). Immunochemistry demonstrated spindle cells positive for S-100 protein. The patient had multiple tumor recurrences and she was evaluated with serial F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). A tumor in the right iliac wing showed increased FDG uptake on PET. FDG-PET played an important role in therapy planning and subsequent follow up. This case emphasizes the important role FDG-PET could play in the staging, restaging, and posttherapy follow up of MPNST.
authors.affiliation: Department of Radiology, Wayne State University/Detroit Medical Center, Detroit, Michigan,USA. chandler@pol.net
authors.forename: Subhash
authors.initials: S
authors.lastname: Chander
authors.forename: Steven M
authors.initials: SM
authors.lastname: Westphal
authors.forename: Imad T
authors.initials: IT
authors.lastname: Zak
authors.forename: David A
authors.initials: DA
authors.lastname: Bloom
authors.forename: Alkis P
authors.initials: AP
authors.lastname: Zingas
authors.forename: Richard N
authors.initials: RN
authors.lastname: Joyrich
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Littrup
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Taub
authors.forename: Todd M
authors.initials: TM
authors.lastname: Getzen
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000556:secondary; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018317:Nerve Sheath Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D009456:Neurofibromatosis 1 / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging*; D009418:S100 Proteins / Q000032:analysis; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D009418:S100 Proteins; D019788:Fluorodeoxyglucose F18