Antiviral activity of ribosome inactivating proteins in medicine.
Pokeweed antiviral protein and several other ribosome inactivating proteins are effective against a broad range of viruses. Recent results have shown that their enzymatic activity is not limited to depurination of the large rRNA, they can depurinate other nucleic acids, including viral RNAs. Antiviral activity of RIPs is summarized here in light of their novel activities and recent developments in the field.
Parikh
Bijal A
BA
Biotechnology Center for Agriculture and the Environment and the Department of Plant Biology and Pathology, Cook College, Rutgers University, New Brunswick, NJ 08903, USA.
Tumer
Nilgun E
NE
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology*; D012270:Ribosomes / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D009696:Nucleic Acids; D011506:Proteins