The 14q restless legs syndrome locus in the French Canadian population.
A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two-point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome.
Levchenko
Anastasia
A
Centre for Research in Neuroscience, McGill University Health Centre Research Institute, Montreal General Hospital, Quebec, Canada.
Montplaisir
Jacques-Yves
JY
Dubé
Marie-Pierre
MP
Riviere
Jean-Baptiste
JB
St-Onge
Judith
J
Turecki
Gustavo
G
Xiong
Lan
L
Thibodeau
Pascale
P
Desautels
Alex
A
Verlaan
Dominique J
DJ
Rouleau
Guy A
GA
D002170:Canada; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D005192:Family Health; D005260:Female; D005602:France / Q000208:ethnology; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012148:Restless Legs Syndrome / Q000235:genetics*