title: A novel fluorescent probe for zinc ion based on boron dipyrromethene (BODIPY) chromophore.
abstract: ZnAB has the combined structure of N,N-bis(2-pyridylmethyl)ethylenediamine as a specific chelater for Zn(2+) and 1,3,5,7-tetramethyl-8-phenyl-boron dipyrromethene as a fluorophore. Complexation of ZnAB with Zn(2+) produces a remarkable enhancement of fluorescence intensity. ZnAB has the advantages of less sensitivity to solvent polarity and pH than fluorescein-based Zn(2+) probes. Furthermore, it is not influenced by other cations, such as Na(+), K(+), Ca(2+), and Mg(2+), which exist at high concentrations under physiological conditions, even at 2.5 mM. The results show that ZnAB is a Zn(2+) probe suitable for biological applications.
authors.affiliation: Daiichi Pure Chemicals Co., Ltd.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Koutaka
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kosuge
authors.forename: Noboru
authors.initials: N
authors.lastname: Fukasaku
authors.forename: Tomoya
authors.initials: T
authors.lastname: Hirano
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Yasuteru
authors.initials: Y
authors.lastname: Urano
authors.forename: Hirotatsu
authors.initials: H
authors.lastname: Kojima
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nagano
mesh_terms: D001896:Boron Compounds / Q000032:analysis / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000032:analysis / Q000737:chemistry*; D015032:Zinc / Q000032:analysis / Q000737:chemistry*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D015032:Zinc