title: Myxoinflammatory fibroblastic sarcoma with complex supernumerary ring chromosomes composed of chromosome 3 segments.
abstract: Myxoinflammatory fibroblastic sarcoma is a rare, recently described, and distinctive low-grade tumor of soft tissue. To our knowledge, there is only one previous report on the cytogenetics of this tumor. That case showed complex structural abnormalities, including a reciprocal translocation between chromosomes 1 and 10 [t(1;10)(p22;q24)] with loss of chromosomes 3 and 13. We describe here a second case showing supernumerary ring chromosomes, and a derivative chromosome 13, with additional material on the short arm. We conclude that the presence of chromosomal abnormalities supports the neoplastic nature of this tumor and aids in its diagnosis. Furthermore, we also postulate that the finding of ring chromosomes, which have been identified in other low-grade soft-tissue tumors, may have important prognostic implications regarding the aggressiveness of this neoplasm.
authors.affiliation: Department of Pathology, Oregon Health and Sciences University, Portland, OR 97239, USA. mansoora@ohsu.edu
authors.forename: Atiya
authors.initials: A
authors.lastname: Mansoor
authors.forename: Nisreen
authors.initials: N
authors.lastname: Fidda
authors.forename: Eleanor
authors.initials: E
authors.lastname: Himoe
authors.forename: Misty
authors.initials: M
authors.lastname: Payne
authors.forename: Helen
authors.initials: H
authors.lastname: Lawce
authors.forename: R Ellen
authors.initials: RE
authors.lastname: Magenis
mesh_terms: D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005354:Fibrosarcoma / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009236:Myxosarcoma / Q000235:genetics* / Q000473:pathology; D012303:Ring Chromosomes; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic