title: Expression of trefoil peptides in the subtypes of intestinal metaplasia.
abstract: We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.
authors.affiliation: Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea. bleok@olmh.cuk.ac.kr
authors.forename: Byung-Wook
authors.initials: BW
authors.lastname: Kim
authors.forename: Kyoung-Mee
authors.initials: KM
authors.lastname: Kim
authors.forename: Bo-In
authors.initials: BI
authors.lastname: Lee
authors.forename: Lee-So
authors.initials: LS
authors.lastname: Maeng
authors.forename: Hwang
authors.initials: H
authors.lastname: Choi
authors.forename: Se-Hyun
authors.initials: SH
authors.lastname: Cho
authors.forename: Hiun-Suk
authors.initials: HS
authors.lastname: Chae
authors.forename: Jae-Kwang
authors.initials: JK
authors.lastname: Kim
authors.forename: Kyu-Yong
authors.initials: KY
authors.lastname: Choi
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Chung
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D004415:Dyspepsia / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009077:Mucins / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D009367:Neoplasm Staging; D010455:Peptides / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins
chemical_list: D014408:Biomarkers, Tumor; D009077:Mucins; D009124:Muscle Proteins; D010455:Peptides; D011506:Proteins; C051838:TFF1 protein, human; C000604007:TFF2 protein, human; C082495:TFF3 protein, human; D000071163:Trefoil Factor-1; D000071164:Trefoil Factor-2; D000071165:Trefoil Factor-3; D025521:Tumor Suppressor Proteins