title: Spiradenocarcinoma of the breast arising in a long-standing spiradenoma.
abstract: The embryologic origin of the breast is related to salivary and sweats glands. Thus, breast neoplasms may show differentiation toward these tissues, although this is a rare event in humans. We report the clinicopathologic and immunohistochemical features of a 57-year-old woman presenting with a spiradenoma that originated in breast tissue and became malignant 40 years later. Some histogenetic concepts relevant to this case are discussed, along with a brief review of this neoplasm.
authors.affiliation: Department of Pathology and Laboratory of Surgical Pathology/Cytopathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes s/n, Campus Universitário Monte Alegre, 14048-900 Ribeirão Preto, São Paulo, Brazil.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ribeiro-Silva
authors.forename: Catarina
authors.initials: C
authors.lastname: Shaletich
authors.forename: Renata Scarpat
authors.initials: RS
authors.lastname: Careta
authors.forename: Dayr Kiomizu
authors.initials: DK
authors.lastname: Kazava
authors.forename: Mateus Campos
authors.initials: MC
authors.lastname: Siqueira
authors.forename: Fábio
authors.initials: F
authors.lastname: Ponton
mesh_terms: D006607:Adenoma, Sweat Gland / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018280:Carcinoma, Skin Appendage / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008408:Mastectomy; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism; D016609:Neoplasms, Second Primary / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013544:Sweat Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; D007633:Keratins