A t(1;9)(q23.3 approximately q25;q34) affecting the ABL1 gene in a biphenotypic leukemia.
Recurring chromosome translocations, which are found in leukemia, can result in the inappropriate expression of oncogenes or in the formation of chimeric genes that code for structurally and functionally abnormal proteins. The chromosomal t(1;9)(q23.3 approximately q25;q34) was found in a patient with biphenotypic leukemia. Fluorescence in situ hybridization (FISH) analysis revealed that the break on chromosome 9 occurred in the ABL1 gene. The breakpoint on chromosome 1 occurred distal to the PBX1 gene at 1q23.3, as shown by FISH using BAC RP11-503N16 and RP11-403P14, which flank the PBX1 locus; hence, the ABL1 gene can be fused with another gene distal to PBX1 gene.
González García
Juan Ramón
JR
Laboratorio de Citogenética, Centro de Investigación Biomédica de Occidente, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (CIBO-IMSS), Colonia Independencia, Guadalajara, Jalisco, Mexico. jrgg_gene@hotmail.com
Bohlander
Stefan K
SK
Gutiérrez Angulo
Melva
M
Esparza Flores
María Amparo
MA
Picos Cárdenas
Verónica Judith
VJ
Meza Espinoza
Juan Pablo
JP
Ayala Madrigal
María de la Luz
Mde L
Rivera
Horacio
H
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019457:Chromosome Breakage; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D010641:Phenotype; D016315:Proto-Oncogene Proteins c-abl / Q000235:genetics*; D012680:Sensitivity and Specificity; D014178:Translocation, Genetic
D016315:Proto-Oncogene Proteins c-abl