Mu-heavy chain disease associated with systemic amyloidosis.
mu-heavy chain disease (HCD) is very rare, with only 30 cases reported in the literature. We report a patient with mu-HCD associated with systemic amyloidosis. The diagnosis of mu-HCD was based on findings of mu-heavy chain fragments in the serum, Bence Jones proteinuria and vacuolated plasma cells in the bone marrow. To our knowledge, this is the third case in which systemic amyloidosis led to the patient's death.
Kinoshita
Koji
K
Department of Hematology, Nephrology and Rheumatology, Kinki Univeristy School of Medicine, Osaka-Sayama, Osaka, Japan.
Yamagata
Toshiaki
T
Nozaki
Yuji
Y
Sugiyama
Masafumi
M
Ikoma
Shinya
S
Funauchi
Masanori
M
Kanamaru
Akihisa
A
D000328:Adult; D000686:Amyloidosis / Q000150:complications*; D001536:Bence Jones Protein / Q000652:urine; D001853:Bone Marrow / Q000473:pathology; D006362:Heavy Chain Disease / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000097:blood; D007148:Immunoglobulin mu-Chains / Q000097:blood; D008297:Male
D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D001536:Bence Jones Protein