title: Effect of ultrasound on acute inflammation of transected medial collateral ligaments.
abstract: OBJECTIVE
  To evaluate the effect of therapeutic ultrasound on the acute inflammation of soft-tissue injuries by measuring the levels of prostaglandin E(2) (PGE(2)) and leukotriene B(4) (LTB(4)).
  
  
  METHODS
  Randomized, case-control study.
  
  
  METHODS
  Laboratory animal facility.
  
  
  METHODS
  Thirty 3-month-old male Sprague-Dawley rats.
  
  
  METHODS
  Rats with medial collateral ligament transection were given 5 minutes of pulsed ultrasound therapy (1:4) daily, with different durations (1, 5, 10d) and intensities (0, 0.5, 1.5, 2.3W/cm(2)).
  
  
  METHODS
  Levels of PGE(2) and LTB(4).
  
  
  RESULTS
  The levels of PGE(2) and LTB(4) were higher in all intensity subgroups that received 2.3W/cm(2) intensity on postinjury day 2. On postinjury day 11, LTB(4) was significantly decreased, but PGE(2) was significantly increased.
  
  
  CONCLUSIONS
  Pulsed ultrasound therapy may stimulate inflammation of acute ligament injury.
authors.affiliation: Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China. rsmcpleung@inet.polyu.edu.hk
authors.forename: Mason C
authors.initials: MC
authors.lastname: Leung
authors.forename: Gabriel Y
authors.initials: GY
authors.lastname: Ng
authors.forename: K K
authors.initials: KK
authors.lastname: Yip
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis; D007249:Inflammation / Q000378:metabolism / Q000628:therapy*; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D017888:Medial Collateral Ligament, Knee / Q000293:injuries* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014464:Ultrasonic Therapy
chemical_list: D007975:Leukotriene B4; D015232:Dinoprostone