Identification of a novel HLA-B*55 variant (B*5513) from a Korean family.
The novel allele, B*5513, was identified from three siblings of a Korean family. Direct DNA sequencing analysis revealed that B*5513 differed from B*5502 by a single-nucleotide substitution at codon 116 (TTA-->TTC) resulting in an amino acid change from leucine to phenylalanine. This substitution altered serologic reactivity of the B55 molecule to B22-specific alloantisera.
Park
H-S
HS
Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, South Korea.
Choi
J-H
JH
Lee
K W
KW
D019943:Amino Acid Substitution; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005091:Exons; D014644:Genetic Variation; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide
D015235:HLA-B Antigens; D004247:DNA