Acupuncture suppresses intrastriatal hemorrhage-induced apoptotic neuronal cell death in rats.
Intracerebral hemorrhage is one of the most devastating types of stroke. In the present study, the effect of acupuncture on intrastriatal hemorrhage-induced neuronal cell death in rats was investigated via Nissl staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, and immunohistochemistry for caspase-3. The present results showed that lesion size and apoptotic neuronal cell death in the striatum were significantly increased following intrastriatal hemorrhage in rats and that acupunctural treatment at the Zusanli acupoint suppressed the hemorrhage-induced increase in lesion size and apoptotic neuronal cell death in the striatum. In the present study, it can be suggested that acupunctural treatment, especially at the Zusanli acupoint, may aid in the recovery following central nervous system sequellae following intracerebral hemorrhage.
Cho
Nam-Hun
NH
Department of Acupuncture and Moxibustion, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
Lee
Jae-Dong
JD
Cheong
Byung-Shik
BS
Choi
Do-Young
DY
Chang
Hyun-Kyung
HK
Lee
Taeck-Hyun
TH
Shin
Min-Chul
MC
Shin
Mal-Soon
MS
Lee
Jongseok
J
Kim
Chang-Ju
CJ
D015670:Acupuncture Therapy / Q000379:methods*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000517:prevention & control*; D003342:Corpus Striatum / Q000473:pathology*; D008297:Male; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley