title: Asymmetric aminolysis of aromatic epoxides: a facile catalytic enantioselective synthesis of anti-beta-amino alcohols.
abstract: [reaction: see text] The first asymmetric aminolysis of trans-aromatic epoxides with anilines is described. The process affords enantioenriched anti-beta-amino alcohols in up to 99% ee. The complete regio- and diastereoselectivity observed uses commercially available [Cr(Salen)Cl] as a Lewis acid catalyst and in combination with a very simple experimental procedure renders the present reaction a facile and practical tool for the synthesis of chiral nonracemic anti-beta-amino alcohols.
authors.affiliation: Department of Organic Chemistry A. Mangini, University of Bologna, v.le Risorgimento 4, 40136 Bologna, Italy. giuseppe.bartoli@unibo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bartoli
authors.forename: Marcella
authors.initials: M
authors.lastname: Bosco
authors.forename: Armando
authors.initials: A
authors.lastname: Carlone
authors.forename: Manuela
authors.initials: M
authors.lastname: Locatelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Massaccesi
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre
authors.forename: Letizia
authors.initials: L
authors.lastname: Sambri