title: Severe resting clonus caused by thyrotoxicosis in a 16-year-old girl with hereditary spastic paraparesis: a case report.
abstract: A 16-year-old girl with a history of hereditary spastic paraparesis developed the subacute onset of severe clonus and new upper-extremity spasticity due to thyrotoxicosis. This case demonstrates the ability of hyperthyroid states to worsen symptoms of spasticity in a child with an underlying spastic disorder. It also demonstrates the importance of investigating for common systemic diseases as a cause of movement disorders even in children with underlying known genetic disorders.
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305-5235, USA. sanger@stanford.edu
authors.forename: Terence D
authors.initials: TD
authors.lastname: Sanger
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D020336:Paraparesis, Spastic / Q000150:complications* / Q000235:genetics*; D012146:Rest; D012640:Seizures / Q000175:diagnosis / Q000209:etiology*; D012720:Severity of Illness Index; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications*; D013972:Thyrotropin / Q000097:blood
chemical_list: D013972:Thyrotropin