Novel chewable sustained-release tablet containing verapamil hydrochloride.
The aim of this research is to produce a compactable self-sealing chewable tablet of verapamil hydrochloride. Tablets were prepared by compressing beads coated with multiple layers including drug, hydroxypropyl methylcellulose, polyethylene oxide, ethylcellulose, lactose, and sodium starch glycolate. Dissolution studies were carried out according to the USP XXII paddle method for 14 h. A new tablet formulation was evaluated in three different forms: 1) whole tablet, 2) crushed tablet using a commercial tablet crusher, and 3) tablet chewed in the mouth and then expelled into dissolution fluid. Sustained release from the new formulation was maintained and was similar in all three different treatments, and similar to drug release from intact commercially available Isoptin SR, but crushing or chewing destroyed the sustained release property of Isoptin SR (as expected). This new formulation can be administered either by swallowing the whole tablet or by first crushing or chewing the tablet. Controlled release properties of this new formulation do not change by chewing or crushing the tablet first. Such a tablet could be valuable for all patients including those who have difficulty swallowing, such as pediatrics and geriatrics.
El-Gazayerly
Omaima N
ON
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA. gazayerly@hotmail.com
Rakkanka
Vipaporn
V
Ayres
James W
JW
D000284:Administration, Oral; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage / Q000737:chemistry*
D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; D014700:Verapamil