title: Selective ring-opening carbonylation of epoxy-steroids.
abstract: Ring-opening alkoxycarbonylation of epoxy-steroids has been carried out with a Co2(CO)8/3-hydroxypyridine catalytic system. High chemo- and regioselectivities were obtained under the reaction conditions applied. Structural analysis of the products proved their high stereochemical purity in each case, accompanied by inversion of the original configuration. No carbonylation took place for sterically hindered steranic epoxides.
authors.affiliation: Department of Organic Chemistry, University of Veszprém, H-8201 Veszprém, P.O. Box 158, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Balázs
authors.forename: Csilla
authors.initials: C
authors.lastname: Benedek
authors.forename: Gábor
authors.initials: G
authors.lastname: Szalontai
authors.forename: Szilárd
authors.initials: S
authors.lastname: Torös
mesh_terms: D002384:Catalysis; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004852:Epoxy Compounds / Q000737:chemistry*; D005663:Furans / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012996:Solutions; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D004852:Epoxy Compounds; D005663:Furans; D012996:Solutions; D013256:Steroids; C018674:tetrahydrofuran