Caveolae and caveolins in the cardiovascular system.
Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.
Gratton
Jean-Philippe
JP
Laboratory of Endothelial Cell Biology, Institut de Recherches Cliniques de Montreal, Canada.
Bernatchez
Pascal
P
Sessa
William C
WC
D000818:Animals; D001692:Biological Transport; D002320:Cardiovascular Physiological Phenomena; D021941:Caveolae / Q000502:physiology*; D022461:Caveolins / Q000235:genetics / Q000502:physiology*; D002451:Cell Compartmentation; D002478:Cells, Cultured / Q000648:ultrastructure; D002784:Cholesterol / Q000378:metabolism; D042783:Endothelial Cells / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D009206:Myocardium / Q000648:ultrastructure; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000502:physiology; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D010641:Phenotype; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction
D022461:Caveolins; D009569:Nitric Oxide; D002784:Cholesterol; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496315:Nos3 protein, mouse; D011505:Protein-Tyrosine Kinases