The pathogenesis and basis for treatment in multiple sclerosis.
The central concept underlying ideas on the pathogenesis of multiple sclerosis is that inflammatory events cause acute injury of axons and myelin. The phases of symptom onset, recovery, persistence and progression in multiple sclerosis can be summarized as functional impairment with intact structure due to direct effects of inflammatory mediators, demyelination and axonal injury with recovery through plasticity and remyelination, and chronic axonal loss due to failure of enduring remyelination from loss of trophic support for axons normally provided by cells of the oligodendrocyte lineage.
Compston
Alastair
A
School of Clinical Medicine, University of Cambridge Neurology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. alastair.compston@medschl.cam.ac.uk
D001369:Axons / Q000473:pathology / Q000502:physiology; D001921:Brain / Q000473:pathology / Q000502:physiology; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D009186:Myelin Sheath / Q000473:pathology / Q000502:physiology; D009836:Oligodendroglia / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation / Q000379:methods*