title: Cholesterol ester transfer protein in children on peritoneal dialysis.
abstract: OBJECTIVE
  To examine whether cholesterol ester transfer protein (CETP) activity and mass contribute to dyslipidemia in children on peritoneal dialysis (PD), and to determine whether CETP activity or mass is responsible for severer hyperlipidemia in smaller (younger) patients.
  
  
  METHODS
  27 patients (18 males, 9 females; mean age 11.8 +/- 6.1 years) were enrolled. Each patient had been receiving PD for more than 6 months. Fasting blood samples were drawn and CETP activity, CETP mass, total cholesterol, triglyceride, beta-lipoprotein profiles, lipoprotein lipid profiles (cholesterol and triglyceride in lipoproteins), apoprotein profile, and serum albumin levels were measured. The results were then compared, using Student's t-test, with those for a control group. In the patient group, the relationships between CETP activity and each factor were examined using simple and multiple regression analyses.
  
  
  RESULTS
  Total cholesterol, triglyceride, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), chylomicron, and ApoB levels were significantly higher in the patient group. Mean CETP activity levels were 106% +/- 24% in the patient group and 111% +/- 21% in the control group. No significant difference in CETP activity was seen between the two groups, but CETP mass was lower in the patient group than in the control group (2.2 +/- 0.6 microL/dL for the patient group vs 2.8 +/- 0.9 microL/dL for the control group, p = 0.01). As a result, specific CETP activity (activity/protein mass ratio) was significantly higher in the patient group (p < 0.0001). CETP activity was positively related to LDL and other atherogenic factors and negatively related to serum albumin level. No relationship between CETP activity and patient body weight was seen.
  
  
  CONCLUSIONS
  Specific CETP activity was higher in the patient group compared with that in the control group, and strong correlations were found between CETP activity and atherogenic factors in the patient group. Therefore, CETP seems to be associated with lipid abnormalities in children on PD but is not responsible for the severer hyperlipidemia seen in smaller children.
authors.affiliation: Department of Pediatrics, Fussa Hospital, Tokyo, Japan. yuriko@amy.hi-ho.ne.jp
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishikura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hataya
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikeda
authors.forename: Masataka
authors.initials: M
authors.lastname: Honda
mesh_terms: D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002352:Carrier Proteins / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology*; D007674:Kidney Diseases / Q000097:blood* / Q000150:complications / Q000628:therapy; D008074:Lipoproteins / Q000097:blood; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008074:Lipoproteins; D012709:Serum Albumin; D014280:Triglycerides