Antimitotic activity of glaupalol-related coumarins from Glaucidium palmatum.
Two new coumarins, glaumacidines A (1) and B (2), and the related coumarins (3-7) have been isolated from the rhizomes of Glaucidium palmatum (Glaucidiaceae). The absolute configurations of 1 and 2 and trans- and cis-glaupadiols (3 and 4, respectively) were elucidated by spectroscopic data, chemical derivatization, and exciton chirality method. Glaupalol (5) enhanced the polymerization of tubulin and affected synergistically with paclitaxel on inhibition of KB cell proliferation.
Morita
Hiroshi
H
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Dota
Tomoka
T
Kobayashi
Jun'ichi
J
D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D002942:Circular Dichroism; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007536:Isomerism; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D008860:Microscopy, Ultraviolet; D008958:Models, Molecular; D017239:Paclitaxel / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*; D013997:Time Factors; D014404:Tubulin / Q000378:metabolism
D000970:Antineoplastic Agents; D003374:Coumarins; D010936:Plant Extracts; D014404:Tubulin; C495821:glaumacidine A; C495820:glaumacidine B; C005510:glaupadiol; D017239:Paclitaxel