[Comparative observation on efficacy of jieyu pill and maprotiline in treating depression].
OBJECTIVE
To investigate the clinical efficacy, adverse reaction and safety of Jieyu pill (JYP) in treating depression.


METHODS
The randomized controlled trial was conducted in 28 patients in the treated group and 29 patients in the control group treated with maprotiline (Map). The efficacy of treatment was evaluated before treatment and 14, 28 and 42 days after treatment, with Hamilton depression rating scale (HAMD), self-rating scale for depression (SDS), self-rating scale for anxiety (SAS) and clinical global impression (CGI), the adverse reaction was assessed by Asberg Rating Scale (ARS).


RESULTS
JYP was effective in treating depression, the markedly effective rate being 78.8%, corresponded to that of Map (82.8%, P > 0.05). After treatment, the scores assessed by HAMD, SDS and SAS were all lower than those before treatment (P < 0.01) respectively, but comparison between the two groups showed insignificant difference (P > 0.05). However, scores of ARS were significantly lower in the treated group than that in the control group, and the efficacy index of JYP was significantly higher than that of Map (P < 0.01).


CONCLUSIONS
JYP in treating depression shows the efficacy corresponded to that of Map and with less adverse reaction.
Shen
Zhen-ming
ZM
5th Hospital of Tangshan City, Hebei Province 063004. zhenmingshen@163.com
Zhu
Mei-lan
ML
Zhao
An-quan
AQ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000627:therapeutic use*; D008875:Middle Aged; D008517:Phytotherapy; D011569:Psychiatric Status Rating Scales
D000928:Antidepressive Agents; D018687:Antidepressive Agents, Second-Generation; D004365:Drugs, Chinese Herbal; D008376:Maprotiline