title: Synthesis and antibacterial activity of novel bifunctional macrolides.
abstract: We report the discovery of a novel class of macrolide antibiotics that have improved antibacterial activity against Ery-resistant organisms.
authors.affiliation: Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60044, USA.
authors.forename: Irini
authors.initials: I
authors.lastname: Akritopoulou-Zanze
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Phelan
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Marron
authors.forename: Hong
authors.initials: H
authors.lastname: Yong
authors.forename: Zhenkun
authors.initials: Z
authors.lastname: Ma
authors.forename: Greg G
authors.initials: GG
authors.lastname: Stone
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Daly
authors.forename: Dena M
authors.initials: DM
authors.lastname: Hensey
authors.forename: Angela M
authors.initials: AM
authors.lastname: Nilius
authors.forename: Stevan W
authors.initials: SW
authors.lastname: Djuric
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004351:Drug Resistance; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D004917:Erythromycin