Hemofiltration in the prevention of radiocontrast agent induced nephropathy.
OBJECTIVE
The aim of the study was to investigate the role of hemofiltration in preventing contrast nephropathy in patients with renal failure.


METHODS
We randomized 114 renal failure patients undergoing percutaneous coronary interventions (PCI) to either peri-procedural hemofiltration or saline hydration.


RESULTS
Contrast nephropathy occurred in 5% of hemofiltration-treated patients and in 50% in controls (P<0.01). In-hospital event rate as well as in-hospital and 1-year mortality rates were lower in patients treated with hemofiltration.


CONCLUSIONS
In patients with renal failure undergoing PCI, peri-procedural hemofiltration is effective for the prevention of contrast nephropathy, and is associated with improved in-hospital and long-term outcome.
Marenzi
G
G
Monzino Heart Center, IRCCS, Institute of Cardiology, University of Milan, Milan, Italy. giancarlo.marenzi@ccfm.it
Bartorelli
A L
AL
D015906:Angioplasty, Balloon, Coronary / Q000401:mortality; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D006440:Hemofiltration; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000150:complications*; D011446:Prospective Studies
D003287:Contrast Media; D003404:Creatinine