Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer.
This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.
Denizot
Yves
Y
Laboratoire d'immunologie, Faculté de Médecine, UMR CNRS 6101, 2 rue Dr. Marcland, Limoges, France. yves.denizot@unilim.fr
Truffinet
Véronique
V
Bouvier
Stéphane
S
Gainant
Alain
A
Cubertafond
Pierre
P
Mathonnet
Muriel
M
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000201:enzymology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011446:Prospective Studies
D010741:Phospholipases A; D054467:Phospholipases A2; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase