title: [Multiple myeloma (IgG-kappa) infiltrating central nervous system, lymph nodes, liver, and kidneys, and with elevation of IgE].
abstract: A 63-year-old man was admitted because of general malaise, fever, headache, generalized lymphadenopathy and hepatomegaly in July 2002. He was diagnosed as having multiple myeloma (MM) (IgG-kappa type) with atypical plasma cells in the bone marrow, lymph nodes and cerebrospinal fluid. Systemic and intrathecal chemotherapy were effective. Because of an increase of polyclonal IgE, electrophoretic patterns revealed an M-peak which was not as sharp as that in IgG myeloma. IgE production is not impaired by the pathologic process in MM patients.
authors.affiliation: Department of Internal Medicine, Yokosuka Kyousai Hospital.
authors.forename: Shigeo
authors.initials: S
authors.lastname: Toyota
authors.forename: Norihiko
authors.initials: N
authors.lastname: Nakamura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Dan
mesh_terms: D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D008099:Liver / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000473:pathology*
chemical_list: D007073:Immunoglobulin E