Using protein folding rates to test protein folding theories.
The fastest simple, kinetically two-state protein folds a million times more rapidly than the slowest. Here we review many recent theories of protein folding kinetics in terms of their ability to qualitatively rationalize, if not quantitatively predict, this fundamental experimental observation.
Gillespie
Blake
B
Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, California 93106, USA. blakeg@chem.ucsb.edu
Plaxco
Kevin W
KW
D007700:Kinetics; D008958:Models, Molecular; D016296:Mutagenesis; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000235:genetics; D013816:Thermodynamics
D011506:Proteins