[Changes of intercellular adhesion molecule-1 and E-selectin levels in plasma of uremic patients treated with maintaining hemodialysis].
OBJECTIVE
To detect the levels of ICAM-1 and E-selectin in plasmas from uremic patients treated by means of maintaining hemodialysis (MHD) and explore the pathological mechanism of atherosclerosis in MHD patients.


METHODS
The levels of ICAM-1 and E-selectin in plasmas from the 105 MHD patients and 25 healthy persons (control group) were detected by dual antibody sandwich ELISA. The cervical atherosclerosis of the patients was examined by type B ultrasonography. Simultaneously, the blood pressures of the patients and control group were taken and recorded, as well as the biochemical criterions in their blood were detected.


RESULTS
(1) The plasma levels of ICAM-1 and E-selectin in MHD patients were significantly higher than those in the control group, respectively (P < 0.01), and in MHD group the above indexes in patients with cervical atherosclerosis were significantly higher than those without cervical atherosclerosis (P < 0.01,P < 0.05). (2) In MHD group, the plasma ICAM-1 level was positively correlated with E-selectin and triglycerides (TG) levels(r = 0.62 and 0.60, respectively), and with the diastolic pressure(r = 0.41,P < 0.05).


CONCLUSIONS
The impairment of vascular endothelial function was obvious in uremic patients with MHD. The changes of ICAM-1 and E-selectin could be accepted as biochemical criterions of vascular endothelial injury. The two adhesion molecules have close relationship with atherosclerosis in MHD patients.
Li
Zhen-jiang
ZJ
Department of Renal Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Xu
Yue-qing
YQ
Chen
Wei
W
Tan
Hua
H
D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D001794:Blood Pressure; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000150:complications / Q000628:therapy
D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1