title: Asymmetric hydrogenation of o-alkoxy-substituted arylenamides.
abstract: A series of (2-alkoxyaryl)glycinols have been prepared in up to 97.8% ee by asymmetric hydrogenation with cationic rhodium Me-BPE or Me-DuPhos complexes. Others have shown that the presence of ortho substituents on related alpha-arylenamides causes a decrease in enantioselectivity. However, in this study it was found that o-alkoxy alpha-arylenamides were reduced with high enantioselectivity irrespective of substituent size.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Cong-Dung Le
authors.forename: Brian L
authors.initials: BL
authors.lastname: Pagenkopf