title: Heart rate variability decreased by coronary artery surgery has no prognostic value.
abstract: BACKGROUND
  Decreased heart rate variability (HRV) may predict cardiac death after myocardial infarction (MI). Coronary artery bypass grafting (CABG) strongly decreases HRV, but improves survival. The aim of the study was to determine the prognostic value of HRV decreased by coronary surgery.
  
  
  METHODS
  Four-year follow-up was performed in 175 consecutive patients with HRV decreased by CABG (51) or MI (124). Mortality and secondary events rate were analysed. Decreased HRV, defined by the standard deviation of mean RR interval (SDNN) < 100 ms, was detected by a routine 24-h Holter electrocardiogram at admission to stationary rehabilitation 3 weeks to 3 months after acute MI or CABG. Two groups did not differ except by age; CABG patients were younger (56 versus 64 years, P<0.01), but this did not influence differences in survival (NS).
  
  
  RESULTS
  HRV was lower among CABG patients than among MI patients (SDNN=66 +/- 20 ms versus 77 +/- 14 ms; P<0.001), but cumulative survival and event-free survival were much better in the CABG group than in the MI group. During a 46 +/- 20 months follow-up, there were 10% new events in the CABG and 43% in the MI group (P<0.001). Mortality was 8% in the CABG and 33% in the MI group (log-rank=3.6; P<0.001). Unlike in the MI group, HRV was not different between survivors and non-survivors in the CABG group.
  
  
  CONCLUSIONS
  In contrast to the strong prognostic potential of HRV in patients with MI, decreased HRV has no prognostic significance in patients who have undergone CABG surgery.
authors.affiliation: Division of Cardiology, General Hospital Sveti Duh, Sveti Duh 64, HR-10000 Zagreb, Croatia. goran.milicevic1@zg.hinet.hr
authors.forename: Goran
authors.initials: G
authors.lastname: Milicevic
authors.forename: Ljubica
authors.initials: L
authors.lastname: Fort
authors.forename: Marcel
authors.initials: M
authors.lastname: Majsec
authors.forename: Vinko
authors.initials: V
authors.lastname: Bakula
mesh_terms: D001026:Coronary Artery Bypass / Q000401:mortality*; D017523:Croatia / Q000453:epidemiology; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality* / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis