title: Disseminated dermatophytosis caused by Microsporum gypseum in an AIDS patient: response to terbinafine and amorolfine.
abstract: A 51-year-old white male, native of Rio de Janeiro, Brazil, with advanced AIDS and in chronic use of imidazoles for oral candidosis, presented erythematous, desquamative, pruriginous plaques of 1 month evolution on the trunk, inguinal/crural region, and lower limbs. The diagnosis of dermatophytosis was based on the isolation of Microsporum gypseum from scales scraped from the skin lesions. The lesions regressed after 30 days treatment with itraconazole, 100 mg day(-1). After interruption of this antifungal, the mycosis recurred 2 months later, along with a toe onychomycosis also caused by M. gypseum. Attempted reintroduction of itraconazole at higher dose was unsuccessful. Patient responded well to treatment with terbinafine 250 mg day(-1) for 45 days. However, the medication had to be interrupted as a result of the emergence of a disseminated erythematous/papulous rash. Topical treatment with amorolfine cream was then performed, with a good clinical and mycological response.
authors.affiliation: Evandro Chagas Clinical Research Institute--Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, Brazil. mclara@ipec.fiocruz.br
authors.forename: M C G
authors.initials: MC
authors.lastname: Galhardo
authors.forename: B
authors.initials: B
authors.lastname: Wanke
authors.forename: R S
authors.initials: RS
authors.lastname: Reis
authors.forename: L A
authors.initials: LA
authors.lastname: Oliveira
authors.forename: A C F
authors.initials: AC
authors.lastname: Valle
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008864:Microsporum; D009025:Morpholines / Q000627:therapeutic use*; D009281:Naphthalenes / Q000627:therapeutic use*; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009025:Morpholines; D009281:Naphthalenes; C038974:amorolfine; D000077291:Terbinafine