Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers.
The role of free radical scavengers in preventing the tissue injury using a non obstructive, ascending mouse model for chronic pyelonephritis was assessed. The parameters taken into consideration are Luminol Dependent Chemiluminescence (LDCL), histopathology and some biochemical investigations. We have observed that both catalase and Dimethyl-Sulfoxide (DMSO, free radical scavengers) were able to prevent the free radical mediated tissue injury and ultimate renal scarring, irrespective of the bacterial strain studied.
Gupta
R
R
Department of Microbiology, Dayanand Medical College and Hospital, Tagore Nagar Civil Lines, Ludhiana, Punjab 141001, India. info@dmchonline.com
Verma
I
I
Sharma
S
S
Ganguly
N K
NK
D000818:Animals; D002374:Catalase / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004195:Disease Models, Animal; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008163:Luminescent Measurements; D051379:Mice; D008807:Mice, Inbred BALB C; D011704:Pyelonephritis / Q000188:drug therapy* / Q000201:enzymology / Q000382:microbiology / Q000473:pathology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D016166:Free Radical Scavengers; D017392:Thiobarbituric Acid Reactive Substances; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D004121:Dimethyl Sulfoxide