Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue.
OBJECTIVE
To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer.


METHODS
The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software.


RESULTS
Compared with normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly (P=0.002, P=0.001, P<0.05). No significant difference was found in the expression of the two NMPs between the various differentiated grades (P=0.947, P=0.356) and clinical stages of gastric cancer (P=0.920, P=0.243, P>0.05).


CONCLUSIONS
The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.
Zhang
Qin-Xian
QX
Molecular Cell Biology Research Center, Medical College of Zhengzhou University, 40 Daxue Lu, Zhengzhou 450052, Henan Province, China. qxz53@zzu.edu.cn
Ding
Yi
Y
Li
Zhuo
Z
Le
Xiao-Ping
XP
Zhang
Wei
W
Sun
Ling
L
Shi
Hui-Rong
HR
D002467:Cell Nucleus / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D034521:Nuclear Matrix-Associated Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism*
D034521:Nuclear Matrix-Associated Proteins