title: [Zeta chain level of T and NK cells in patients with renal-cell carcinoma and bladder cancer and its clinical significance].
abstract: OBJECTIVE
  To study the relationship between zeta chain level of peripheral blood T/NK cells and tumor progression in renal-cell carcinoma and bladder cancer and its clinical significance.
  
  
  METHODS
  The peripheral blood mononuclcear cells in 58 patients with renal cell carcinoma, 22 patients with bladder cancer and 14 healthy blood donors were examined by flow cytometry with fluorescent anti-CD3 (for T cells), or anti-CD56 (for NK cells) and anti-zeta chain monoclonal antibodies.
  
  
  RESULTS
  The zeta chain expression of T cell and NK cell in stage I, II and III renal-cell carcinoma decreased to 59.5%, 37.6%, 21.3% and 62.2%, 27.1%, 18.8% of the healthy control level, respectively. That in stage I, II and III bladder cancer decreased to 37.6%, 29.5%, 18.9% and 35.4%, 20.8%, 5.8% of the control level, respectively. T and NK cell zeta chain levels in 17.5% (14/80) of the patients were within the normal range. T/NK ratios of peripheral blood in stage III patients were remarkably lower than those of the healthy donor.
  
  
  CONCLUSIONS
  Reduced T and NK zeta chain levels and T/NK ratio in the renal-cell carcinoma and bladder cancer are generally consistent with tumor progression. The patients with normal T and NK zeta chain level may be indicated for immunotherapy.
authors.affiliation: Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Chang-Ling
authors.initials: CL
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Zhou
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Ma
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.forename: Shu-Ren
authors.initials: SR
authors.lastname: Zhang
mesh_terms: D002292:Carcinoma, Renal Cell / Q000276:immunology* / Q000628:therapy; D005434:Flow Cytometry; D006801:Humans; D007167:Immunotherapy; D007680:Kidney Neoplasms / Q000276:immunology* / Q000628:therapy; D007694:Killer Cells, Natural / Q000276:immunology*; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000097:blood*; D013601:T-Lymphocytes / Q000276:immunology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; C054979:antigen T cell receptor, zeta chain