title: Sonogashira cross-couplings of ynamides. Syntheses of urethane- and sulfonamide-terminated conjugated phenylacetylenic systems.
abstract: [reaction: see text] The first successful Sonogashira coupling of ynamides with aryl and vinyl iodides is described here. This study resolves the problem of the competing pathway involving homocoupling of ynamides and provides a practical entry to novel urethane- or sulfonamide-terminated conjugated acetylenic systems. An interesting tandem hydrohalogenation and Sonogashira coupling was also observed to give an en-ynamide.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Tracey
authors.forename: Yanshi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Michael O
authors.initials: MO
authors.lastname: Frederick
authors.forename: Jason A
authors.initials: JA
authors.lastname: Mulder
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung