title: Clinical and laboratory diagnosis of deep vein thrombosis: new cost-effective strategies.
abstract: Diagnosis of deep vein thrombosis (DVT) has been made easier, less invasive, and somewhat safer over the past 2 decades. This has been due mainly to the development of venous compression ultrasonography (US). The prevalence of the disease in patients clinically suspected of DVT has steadily decreased during the past 10 years, likely as a consequence of the accurate noninvasive test, ultrasound imaging. This has led to the development of diagnostic tools that aim at reducing the number of unnecessary US exams. These include clinical probability assessment and fibrin D-dimer. Several strategies combining these tools have been validated in large-outcome studies and compared in a formal cost-effectiveness analysis. The results indicate that they should now be implemented in daily practice, taking into account local facilities and expertise.
authors.affiliation: Division of Angiology and Hemostasis, Medical Clinic, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Bounameaux
authors.forename: A
authors.initials: A
authors.lastname: Perrier
authors.forename: P S
authors.initials: PS
authors.lastname: Wells
mesh_terms: D000465:Algorithms; D003362:Cost-Benefit Analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006801:Humans; D019057:Quality-Adjusted Life Years; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000191:economics
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D