The study on the synthesis and the effects on the intracellular calcium of some 9-substituted-phenanthrene derivatives.
Some 9-(substituted with heteroaryl)-phenanthrene compounds, polycyclic aromatic hydrocarbons (PAH), were obtained by two different methods. In the first method, 9-phenanthraldehyde was reacted with some dion compounds such as benzil, toluil, anisil, etc in the presence of ammonium acetate and glacial acetic acid. In the second method, 9-phenanthraldehyde was reacted with 5-substituted-1,2-phenylenediamine derivatives in the presence of NaHSO3 and ethanol. All of synthesized compounds by us were original and these compounds have not been studied in literature so far. The structures of compounds were confirmed by spectral data and elemental analyses results. The effects of compounds were studied on intracellular calcium level. All of the compounds were examined between the concentrations of 1 and 0.5 microg/mL.
Isikdag
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I
Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University, Eskisehir, Turkey.
Meric
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A
Gÿnes
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S
Incesu
Z
Z
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D005456:Fluorescent Dyes; D016257:Fura-2; D051379:Mice; D010616:Phenanthrenes / Q000138:chemical synthesis / Q000494:pharmacology*
D005456:Fluorescent Dyes; D010616:Phenanthrenes; D002118:Calcium; D016257:Fura-2