title: Liver transplantation for unresectable perihilar cholangiocarcinoma.
abstract: Patients with unresectable, stage I and II perihilar cholangiocarcinoma were treated with neoadjuvant external beam irradiation, brachytherapy, and 5-fluorouracil and/or oral capecitabine prior to liver transplantation. Fifty-six patients underwent treatment between 1993 and 2003. Four patients died and 4 had disease progression prior to completion of neoadjuvant therapy. Forty-eight patients underwent operative staging and 14 had findings precluding transplantation. Twenty-eight patients underwent transplantation and 6 patients are awaiting transplantation. Three patients died from perioperative complications, and 4 developed recurrent disease 22 to 63 months after transplantation. Actuarial patient survival was 54% at 5 years for all 56 patients, 64% for 48 operatively staged patients, and 84% for 34 patients with negative staging operations. Actuarial survival was 88% at 1 year and 82 % 5 years after transplantation. Neoadjuvant chemoradiotherapy with liver transplantation achieves excellent results for patients with localized, regional lymph node negative, hilar cholangiocarcinoma.
authors.affiliation: William J von Liebig Transplant Center, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
authors.forename: Julie K
authors.initials: JK
authors.lastname: Heimbach
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Gores
authors.forename: Michael G
authors.initials: MG
authors.lastname: Haddock
authors.forename: Steven R
authors.initials: SR
authors.lastname: Alberts
authors.forename: Scott L
authors.initials: SL
authors.lastname: Nyberg
authors.forename: Michael B
authors.initials: MB
authors.lastname: Ishitani
authors.forename: Charles B
authors.initials: CB
authors.lastname: Rosen
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001650:Bile Duct Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D001918:Brachytherapy; D018281:Cholangiocarcinoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D015996:Survival Rate; D016896:Treatment Outcome