Transcriptional control of thymocyte positive selection.
Thymocyte development proceeds through multiple regulated checkpoints to ensure that the mature T-cell population is useful for recognition of self major histocompatibility complex (MHC) molecules, but not overtly autoreactive. Developing cells pass the positive selection checkpoint when the T-cell receptor (TCR) on immature thymocytes engages self peptide/MHC with low affinity. The resulting signal transduction initiates migration, survival, maturation, allelic exclusion, and lineage commitment. The changes in gene expression necessary for all of these cellular events are controlled by transcription factors responsive to signals in immature thymocytes. Recent progress has defined a small group of transcription factors that can be clearly linked to regulation of gene expression during positive selection.
Kersh
Gilbert J
GJ
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 101 Woodruff Circle, Rm. 7311 Memorial Building, Atlanta, GA 30322, USA. gkersh@emory.edu
D000818:Animals; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology; D016827:CD8 Antigens / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic
D015704:CD4 Antigens; D016827:CD8 Antigens; D014157:Transcription Factors