title: Anti-platelet pentacyclic triterpenoids from leaves of Campsis grandiflora.
abstract: Five pentacyclic triterpenoids, oleanolic acid (1), hederagenin (2), ursolic acid (3), tormentic acid (4) and myrianthic acid (5), were isolated from the methanol extract of the leaves of Campsis grandiflora, and structures of the compounds were established by the spectroscopic methods. Compounds 2, 3, 4, and 5 were isolated for the first time from the genus Campsis. All of the compounds (IC50: 45.3, 32.8, 82.6, 42.9 and 46.2 microM respectively) were as equivalently inhibitive as acetylsalicylic acid (IC50: 57.0 microM) on epinephrine induced platelet aggregation.
authors.affiliation: Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
authors.forename: Jing Ling
authors.initials: JL
authors.lastname: Jin
authors.forename: Yong Yook
authors.initials: YY
authors.lastname: Lee
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Heo
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Jeong Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Hye Sook
authors.initials: HS
authors.lastname: Yun-Choi
mesh_terms: D000818:Animals; D029402:Bignoniaceae; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D014315:Triterpenes