Chemotherapeutic targeting of etoposide to various tissues on the basis of polyamine level.
The effects of etoposide on body weight, organ weights and the concentrations of putrescine, spermidine and spermine in 14 different tissues were examined in rats that had been given the drug for five consecutive days. Etoposide reduces all polyamines, which are associated with tumor cell growth, in the thymus and reduces polyamines of two kinds in the spleen, heart, small intestine, skeletal muscle and lung but it increases putrescine in the prostate and spleen, and spermine in the large intestine.
Watanabe
Satoru
S
Department of Pharmacology, Kawasaki Medical School, 577 Matsushima 701-0192, Kurashiki City, Okayama, Japan. sunsw@med.kawasaki-m.ac.jp
Sato
Shoichi
S
Nagase
Sumika
S
Shimosato
Kazuaki
K
Ohkuma
Seitaro
S
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005047:Etoposide / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009928:Organ Specificity; D011073:Polyamines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011700:Putrescine / Q000037:antagonists & inhibitors / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000972:Antineoplastic Agents, Phytogenic; D011073:Polyamines; D005047:Etoposide; D011700:Putrescine