[Successful corticosteroid treatment of thrombocytopenia in a pregnant woman with myelodysplastic syndrome (refractory anemia)].
A 31-year-old pregnant woman was referred to our hospital due to anemia and thrombocytopenia, and was diagnosed as having myelodysplastic syndrome (refractory anemia) with autoimmune thrombocytopenia. Administration of high dose methylprednisolone and gamma-globulin did not raise her platelet count, and she subsequently delivered a healthy baby after the transfusion of a large amount of platelets. Although the anemia spontaneously improved after delivery, the platelet count remained unchanged. Prednisolone was thus administered a second time, which did finally increase the platelet count. This is the first reported case of a pregnant woman with myelodysplastic syndrome in whom corticosteroid administration was effective for thrombocytopenia.
Murase
Kazuyuki
K
Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine.
Matsunaga
Takuya
T
Takimoto
Rishu
R
Takahira
Naoki
N
Fujimi
Akihito
A
Takeuchi
Naoko
N
Terui
Takeshi
T
Niitsu
Yoshiro
Y
D000328:Adult; D000753:Anemia, Refractory / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D009190:Myelodysplastic Syndromes / Q000150:complications*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011644:Puerperal Disorders / Q000188:drug therapy*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*
D008775:Methylprednisolone