title: Synthesis of N-sugar-substituted phthalimides and their derivatives from sugar azides and phthalic anhydride.
abstract: N-Sugar-substituted phthalimides and tetrachlorophthalimide derivatives can be prepared in good yields under essentially neutral conditions. Mixing a sugar azide, NaI, Me3SiCl, phthalic or substituted phthalic anhydride and tetrabutylammonium iodide as catalyst in acetonitrile at rt or 60 degrees C, afforded 12 imides in 83-95% yields.
authors.affiliation: Department of Chemical Biology, School of Pharmaceutical Sciences, National Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China.
authors.forename: Su-Na
authors.initials: SN
authors.lastname: Zhang
authors.forename: Zhong-Jun
authors.initials: ZJ
authors.lastname: Li
authors.forename: Meng-Shen
authors.initials: MS
authors.lastname: Cai
mesh_terms: D001386:Azides / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D015394:Molecular Structure; D010796:Phthalic Anhydrides / Q000737:chemistry*; D010797:Phthalimides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001386:Azides; D002241:Carbohydrates; D010796:Phthalic Anhydrides; D010797:Phthalimides