Tacrolimus and transplantation: a decade in review.
The concept of replacing failing organs or tissues with healthy ones is as old as civilization itself, but it was not until 1954 that the first successful human kidney transplant was performed. Since then, improved surgical techniques and organ preservation, greater understanding of immunologic barriers, and the development of newer and more potent immunosuppressives have combined to make human organ transplantation relatively routine. Key to the success of transplantation is tacrolimus, originally known as FR000506. The compound, which suppresses interleukin-2 production associated with T-cell activation, inhibits differentiation and proliferation of cytotoxic T cells. Today, it is recognized worldwide as the cornerstone of immunosuppressant therapy.
Fung
John J
JJ
Thomas E. Starzl Transplantation Institute, Department of Surgery, Pittsburgh, PA 15213, USA.
D049673:History, 20th Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use*; D008213:Lymphocyte Activation / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology; D016559:Tacrolimus / Q000266:history / Q000494:pharmacology / Q000627:therapeutic use*; D019737:Transplants / Q000266:history
D007166:Immunosuppressive Agents; D016559:Tacrolimus