title: Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS.
abstract: Outbreaks of infectious diseases such as HIV and the much televised and attention-getting outbreaks of diseases such as Ebola, Hantaviruses, and the most recent outbreak of SARS have induced a significant new interest in the formulations and more importantly the science of vaccinology, which has previously to a large extent been conducted empirically. Our laboratory has focused on the use of recombinant nonhuman primate cytokines as adjunctive therapies for inducing antigen-specific immune responses in monkeys because most recombinant human cytokines appear to be immunogenic. This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA. pathaaa@emory.edu
authors.forename: Aftab A
authors.initials: AA
authors.lastname: Ansari
authors.forename: Ann E
authors.initials: AE
authors.lastname: Mayne
authors.forename: Nattawat
authors.initials: N
authors.lastname: Onlamoon
authors.forename: Kovit
authors.initials: K
authors.lastname: Pattanapanyasat
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Mori
authors.forename: Francois
authors.initials: F
authors.lastname: Villinger
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000276:Adjuvants, Immunologic / Q000235:genetics / Q000627:therapeutic use*; D000818:Animals; D016207:Cytokines / Q000235:genetics* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics / Q000276:immunology; D018664:Interleukin-12 / Q000235:genetics / Q000276:immunology; D019409:Interleukin-15 / Q000235:genetics / Q000276:immunology; D007376:Interleukin-2 / Q000235:genetics / Q000276:immunology; D008253:Macaca mulatta; D011994:Recombinant Proteins / Q000235:genetics / Q000627:therapeutic use; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D019409:Interleukin-15; D007376:Interleukin-2; D011994:Recombinant Proteins; D018664:Interleukin-12; D007371:Interferon-gamma