[The role of N-acetyltransferase polymorphism in the pathogenesis of Parkinson's disease].
Pathogenesis of many diseases is related to the influence of noxious environmental agents coupled with individual genetic sensitivity that depends on the function of detoxificating enzymes. One of the latter is N-acetyltransferase 2 whose mutations lead to an impairment of the enzyme function. Genetically determined acetylation rate reduction with exposure to neurotoxins may contribute to the development of Parkinson's disease (PD). While both genetic and environmental factors are implicated in etiology of PD, genetic factors may play a crucial role in early-onset Parkinson's disease (in patients aged under 50).
Kłodowska-Duda
Gabriela A
GA
Kliniki Neurologii Wieku Podeszłego Slaskiej Akademii Medycznej w Katowicach. neurowp@infomed.slam.katowice.pl
Opala
Grzegorz M
GM
Ochudło
Stanisław G
SG
D001191:Arylamine N-Acetyltransferase / Q000235:genetics* / Q000378:metabolism; D004781:Environmental Exposure / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D001191:Arylamine N-Acetyltransferase