title: Management of stage I cervical sarcoma botryoides in childhood and adolescence.
abstract: Rhabdomyosarcomas are the most common soft tissue sarcomas in childhood. The botryoid variant arises in infancy from the vagina or urinary bladder and extremely rarely from the uterine cervix. Treatment regimes range from local excision of the tumour to radical hysterectomy with adjuvant multidrug therapy and/or radiotherapy. In cases of minimal cervical invasion, the less invasive local excision in combination with adjuvant chemotherapy has resulted in excellent survival rates with complete functional preservation of the bladder, rectum, vagina, and ovaries. We present here a 30-year literature review and a case report of a cervical sarcoma botryoides in a 5-year-old girl.
  
  
  CONCLUSIONS
  based on the literature review and our own observation, we recommend minor surgical approaches in combination with chemotherapy as the treatment of choice for early stage I cervical rhabdomyosarcoma.
authors.affiliation: Department of Obstetrics and Gynaecology, Justus-Liebig-University Giessen, Klinikstrasse 32, Giessen, Germany. susanne.gruessner@gyn.med.uni-giessen.de
authors.forename: Susanne E M
authors.initials: SE
authors.lastname: Gruessner
authors.forename: Charles O A
authors.initials: CO
authors.lastname: Omwandho
authors.forename: Thomas
authors.initials: T
authors.lastname: Dreyer
authors.forename: Renate
authors.initials: R
authors.lastname: Blütters-Sawatzki
authors.forename: Alfred
authors.initials: A
authors.lastname: Reiter
authors.forename: Hans R
authors.initials: HR
authors.lastname: Tinneberg
authors.forename: Rainer M
authors.initials: RM
authors.lastname: Bohle
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D009367:Neoplasm Staging; D018233:Rhabdomyosarcoma, Embryonal / Q000473:pathology* / Q000628:therapy*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D007069:Ifosfamide