Association of matrix metalloproteinase (MMP)-1 promoter polymorphism with head and neck squamous cell carcinoma.
To explore the relation of the MMP-1 1G/2G and MMP-3 5A/6A promoter polymorphisms with head and neck squamous cell carcinoma (HNSCC), DNA specimens extracted from peripheral blood cells of HNSCC patients and healthy controls were genotyped. The frequency of the MMP-1 2G/2G genotype was significantly higher in HNSCC patients (n = 140) than in age- and sex-matched controls (n = 223) (P = 0.042; OR, 1.56). In the MMP-3 polymorphism, there was no significant difference in the genotype distribution between patients and controls. These data suggest that the MMP-1 promoter polymorphism may be associated with HNSCC.
Hashimoto
Tomoko
T
Department of Otolaryngology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Uchida
Kenichiro
K
Okayama
Naoko
N
Imate
Yuji
Y
Suehiro
Yutaka
Y
Hamanaka
Yuichiro
Y
Ueyama
Yoshiya
Y
Shinozaki
Fumihiko
F
Yamashita
Hiroshi
H
Hinoda
Yuji
Y
D000328:Adult; D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D005260:Female; D006258:Head and Neck Neoplasms / Q000201:enzymology*; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D019278:Matrix Metalloproteinase 3; D020781:Matrix Metalloproteinase 1