title: Simultaneous nonparotid cranial mucosa-associated lymphoid tissue lymphoma and common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVID) is a condition characterized by low levels of immunoglobulin (Ig) G and either IgA or IgM in the presence of recurrent infections. This disorder is associated with an increased risk of malignancy. Mucosa-associated lymphoid tissue (MALT) lymphoma is a recently recognized form of non-Hodgkin's lymphoma that is not often present in the head. MALT lymphoma in patients with CVID is rare, and until now, it has not been reported in a cranial location outside of the parotid gland. We report the cases of 2 patients who had CVID and cranial MALT lymphoma outside of the parotid gland, and we describe their successful treatment with chemotherapy.
authors.affiliation: Department of Medicine, University Hospitals of Cleveland, Ohio, USA.
authors.forename: Haig
authors.initials: H
authors.lastname: Tcheurekdjian
authors.forename: Oliver
authors.initials: O
authors.lastname: Jenkins
authors.forename: Robert
authors.initials: R
authors.lastname: Hostoffer
mesh_terms: D018951:Antigens, CD20 / Q000276:immunology; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology; D009918:Orbital Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology; D010255:Paranasal Sinus Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000276:immunology; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D018951:Antigens, CD20; D000970:Antineoplastic Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D014747:Vinblastine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide