[Non-parametric estimation of survival function for recurrent events data].
Recurrent events when we deal with survival studies demand a different methodology from what is used in standard survival analysis. The main problem that we found when we make inference in these kind of studies is that the observations may not be independent. Thus, biased and inefficient estimators can be obtained if we do not take into account this fact. In the independent case, the interocurrence survival function can be estimated by the generalization of the limit product estimator (Peña et al. (2001)). However, if data are correlated, other models should be used such as frailty models or an estimator proposed by Wang and Chang (1999), that take into account the fact that interocurrence times were or not correlated. The aim of this paper has been the illustration of these approaches by using two real data sets.
González
Juan R
JR
Servicio de Epidemiología y Registro del Cáncer, Institut Català d'Oncologia, Avda. Gran Vía s/n, km 2,7, L'Hospitalet de Llobregat 08907-Barcelona, Spain. jrgonzalez@ico.scs.es
Peña
Edsel A
EA
D003627:Data Interpretation, Statistical; D006801:Humans; D015233:Models, Statistical; D018709:Statistics, Nonparametric; D016019:Survival Analysis