[Immunobiological properties of 100 years old Bacillus anthracis vaccine strains Lange].
The results of the study of B. anthracis vaccine strains Lange 1 and 2 in the form of spores after prolonged storage in 30% glycerine solution at room temperature are presented. The study revealed that spores stored for 100 years germinated and bacterial cells proved to be viable when cultivated in artificial nutrient media and in vivo. They exhibited typical cultural, morphological, biochemical, virulent, antigenic and immunogenic properties.
Sheremet'eva
Iu V
IuV
Academy of Veterinary Medicine, Kazan, Republic of Tatarstan, Russia.
Gosmanov
R G
RG
Salmakov
K M
KM
Gosmanov
N R
NR
D000818:Animals; D000881:Anthrax / Q000821:virology*; D001408:Bacillus anthracis / Q000472:pathogenicity / Q000502:physiology*; D001428:Bacterial Vaccines / Q000032:analysis*; D004356:Drug Storage / Q000706:statistics & numerical data*; D005990:Glycerol; D006168:Guinea Pigs; D051379:Mice; D013171:Spores, Bacterial / Q000254:growth & development; D013696:Temperature; D013997:Time Factors; D014774:Virulence
D001428:Bacterial Vaccines; D005990:Glycerol