title: The 14q restless legs syndrome locus in the French Canadian population.
abstract: A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two-point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome.
authors.affiliation: Centre for Research in Neuroscience, McGill University Health Centre Research Institute, Montreal General Hospital, Quebec, Canada.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Levchenko
authors.forename: Jacques-Yves
authors.initials: JY
authors.lastname: Montplaisir
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Dubé
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Riviere
authors.forename: Judith
authors.initials: J
authors.lastname: St-Onge
authors.forename: Gustavo
authors.initials: G
authors.lastname: Turecki
authors.forename: Lan
authors.initials: L
authors.lastname: Xiong
authors.forename: Pascale
authors.initials: P
authors.lastname: Thibodeau
authors.forename: Alex
authors.initials: A
authors.lastname: Desautels
authors.forename: Dominique J
authors.initials: DJ
authors.lastname: Verlaan
authors.forename: Guy A
authors.initials: GA
authors.lastname: Rouleau
mesh_terms: D002170:Canada; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D005192:Family Health; D005260:Female; D005602:France / Q000208:ethnology; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012148:Restless Legs Syndrome / Q000235:genetics*