Effect of macrocyclic binuclear oxovanadium complex on tissue defense system in streptozotocin-induced diabetic rats.
BACKGROUND
Oxidative stress plays an important role in chronic complications of diabetes mellitus and hence the regulation of free radicals is essential in the treatment of diabetes. The protective effect of a new macrocyclic binuclear oxovanadium complex on antioxidant defense systems of liver and kidney was examined in streptozotocin-induced experimental diabetes in rats.


METHODS
The levels of lipid peroxides, glutathione and the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase were assayed according to standard procedures in the liver and kidney of control and experimental groups of rats.


RESULTS
A significant decrease (p < 0.05) was observed in both the glutathione content and in the activities of antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase and a concomitant increase in the level of lipid peroxides in diabetic rats. The observed alterations in the antioxidant status of tissues reverted back to near normal levels after the oral administration of macrocyclic vanadium complex at a dose of 5 mg/kg body weight/rat/day for a period of 30 days.


CONCLUSIONS
The normoglycemic efficacy of the vanadium complex alleviates oxidative stress in streptozotocin-induced diabetes in rats.
Ramachandran
Balasubramanian
B
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India.
Ravi
Kasiappan
K
Narayanan
Vengidusamy
V
Kandaswamy
Muthusamy
M
Subramanian
Sorimuthu
S
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005951:Glucose Tolerance Test; D005978:Glutathione / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007202:Indicators and Reagents; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D017968:Vanadium Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
D001786:Blood Glucose; D006454:Hemoglobins; D007202:Indicators and Reagents; D011083:Polycyclic Compounds; D017392:Thiobarbituric Acid Reactive Substances; D017968:Vanadium Compounds; D005978:Glutathione