Prevalence and exoenzyme secretion by Candida albicans isolates from oral and vaginal mucosas of HIV-infected women.
A cross-sectional study was performed to evaluate the prevalence and the aetiology of forms of mucosal fungal infections of HIV-negative and HIV-positive women. Candida albicans was the predominate specie isolated from both groups of patients, with remarkable proportion of isolation from symptomatic women. All 239 C. albicans isolates, regardless of their source, showed activity of proteinase and phospholipase. It was verified that isolates with particularly higher levels of exoenzymes production were significantly more common in HIV-positive patients. However, isolates obtained from the HIV-positive patients in use of HAART, with protease inhibitor, presented lower levels of these exoenzymes, similar to the levels observed in the isolates from HIV-negative patients.
Ribeiro
Mariceli Araujo
MA
Núcleo de Doenças Infecciosas, Centro Biomedico da Universidade Federal do Espirito Santo, Vitoria, Brazil. mariceli@ebrnet.com.br
Miranda
Angelica Espinosa
AE
Gambale
Walderez
W
Paula
Claudete Rodrigues
CR
D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001938:Brazil / Q000453:epidemiology; D002176:Candida albicans / Q000201:enzymology* / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology; D002177:Candidiasis / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D003430:Cross-Sectional Studies; D010450:Endopeptidases / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000382:microbiology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology; D010740:Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015995:Prevalence; D011480:Protease Inhibitors / Q000494:pharmacology; D014621:Vagina / Q000382:microbiology
D011480:Protease Inhibitors; D010740:Phospholipases; D010450:Endopeptidases