A structural perspective on protein-protein interactions.
Structures of macromolecular complexes are necessary for a mechanistic description of biochemical and cellular processes. They can be solved by experimental methods, such as X-ray crystallography, NMR spectroscopy and electron microscopy, as well as by computational protein structure prediction, docking and bioinformatics. Recent advances and applications of these methods emphasize the need for hybrid approaches that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness.
Russell
Robert B
RB
EMBL, Heidelberg, Germany.
Alber
Frank
F
Aloy
Patrick
P
Davis
Fred P
FP
Korkin
Dmitry
D
Pichaud
Matthieu
M
Topf
Maya
M
Sali
Andrej
A
D000818:Animals; D018360:Crystallography, X-Ray / Q000379:methods; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008854:Microscopy, Electron / Q000379:methods; D008958:Models, Molecular; D011487:Protein Conformation; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D040681:Structural Homology, Protein; D014054:Tomography / Q000379:methods
D011506:Proteins