Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulation.
A 73-year-old man with Parkinson's disease underwent thalamic stimulation for disabling tremor with excellent results only when stimulation on. Post-mortem neuropathology (7 years postoperatively) revealed 60% cell loss within 0.5 mm of the electrode tip. Tremor improvement was attributable to chronic stimulation, not microthalamotomy.
Henderson
Jasmine
J
Department of Pharmacology, University of Sydney, NSW, Australia. henderson@med.usyd.edu.au
Rodriguez
Michael
M
O'Sullivan
Dudley
D
Pell
Malcolm
M
Fung
Victor
V
Benabid
Alim Louis
AL
Halliday
Glenda
G
D004558:Electric Stimulation / Q000295:instrumentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D011846:Radio Waves; D020651:Ventral Thalamic Nuclei / Q000473:pathology*