Blood dendritic cells in patients with acute lymphoblastic leukaemia.
Myeloid and plasmacytoid dendritic cells (MDCs, PDCs) play a key role in the initiation of immune responses. In this study, we show a severe reduction of MDCs and PDCs in patients with B lineage acute lymphoblastic leukaemia (B-ALL; P = 0.01 vs. controls). DCs from patients with T lineage ALL (T-ALL) were quantitatively and functionally comparable to healthy donors, as demonstrated by secretion of interleukin (IL)-12p70 and interferon-alpha. In vitro, the circulating CD34(+) fraction of B-ALL cases did not generate either CD1a(+) MDCs or PDCs, suggesting that DC development is probably affected in B-ALL, but not in T-ALL.
Mami
Naira Ben
NB
Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, 232 Bd. Ste. Marguerite, 13273 Marseille Cedex 09, France.
Mohty
Mohamad
M
Chambost
Hervé
H
Gaugler
Béatrice
B
Olive
Daniel
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000276:immunology; D002051:Burkitt Lymphoma / Q000276:immunology; D016022:Case-Control Studies; D002452:Cell Count; D002478:Cells, Cultured; D002648:Child; D003713:Dendritic Cells / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D007223:Infant; D015847:Interleukin-4 / Q000494:pharmacology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000276:immunology; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D018709:Statistics, Nonparametric
D018952:Antigens, CD34; D018950:Lipopolysaccharide Receptors; D015847:Interleukin-4; D016178:Granulocyte-Macrophage Colony-Stimulating Factor