SLC22A4 and RUNX1: identification of RA susceptible genes.
Recently we reported that SLC22A4 and RUNX1 are associated with rheumatoid arthritis (RA). SLC22A4 is an organic cation transporter with unknown physiological function, and RUNX1 is a hematological transcriptional regulator that has been shown to be responsible for acute myelogenic leukemia. It is suggested that the association of RUNX1 with RA is due to its regulation of expression of SLC22A4. Because the physiological function of SLC22A4 is still unclear, further investigation is needed into how SLC22A4 affects RA susceptibility. Although the association of RUNX1 with RA was identified as a regulatory factor of SLC22A4, it is possible that RUNX1 is a key molecule in autoimmunity, as it has been reported to be associated with systemic lupus erythematosus and psoriasis, two other autoimmune diseases.
Yamada
Ryo
R
Laboratory for Rheumatic Diseases, SNP Research Center, Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Kanagawa, Japan. ryamada@src.riken.go.jp
Tokuhiro
Shinya
S
Chang
Xiotian
X
Yamamoto
Kazuhiko
K
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics / Q000502:physiology; D051017:Apoptosis Regulatory Proteins; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000235:genetics; D026901:Membrane Transport Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008957:Models, Genetic; D020412:Multifactorial Inheritance; D027701:Organic Cation Transport Proteins; D020641:Polymorphism, Single Nucleotide; D061026:Programmed Cell Death 1 Receptor; D011401:Promoter Regions, Genetic / Q000235:genetics; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics; D027981:Symporters; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology
D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D026901:Membrane Transport Proteins; D027701:Organic Cation Transport Proteins; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; C493726:Runx1 protein, mouse; C109807:SLC22A4 protein, human; D027981:Symporters; D014157:Transcription Factors