Increase in cord blood soluble E-selectin and tracheal aspirate neutrophils at birth and the development of new bronchopulmonary dysplasia.
OBJECTIVE
To test the hypothesis that preterm infants who develop new type of bronchopulmonary dysplasia BPD have higher cord blood sE-selectin levels and neutrophil counts in the tracheal aspirate at birth than those who do not.


METHODS
The relationship between cord blood sE-selectin levels and neutrophil counts in the tracheal aspirate at birth and the development of BPD was examined in 30 preterm infants. Levels of sE-selectin and neutrophil counts were measured by specific immunoassay and by cytospin analysis.


RESULTS
Median cord blood levels of sE-selectin and neutrophil counts in the tracheal aspirate at birth were higher in preterm infants who developed BPD than in those who did not (P<0.01 for each). These differences persisted significantly after adjusting for the effects of gestational age and the presence of histologic chorioamnionitis and patent ductus arteriosus PDA (P<0.01 for each).


CONCLUSIONS
Fetal pulmonary inflammation, as measured by increased cord blood levels of sE-selectin and neutrophil counts in the tracheal aspirate at birth, may be a risk factor for the development of new BPD in preterm infants. These results support the hypothesis that the lung injury responsible for new BPD in preterm infants can begin in the prenatal period and could be associated with a fetal pulmonary inflammation.
Kim
Beyong Il
BI
Department of Pediatrics, Seoul National University College of Medicine, and the Laboratory of Fetal Medicine Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea. beyil@snu.ac.kr
Lee
Hee Eun
HE
Choi
Chang Wong
CW
Jo
Heui Seung
HS
Choi
Eun Hwan
EH
Koh
Young Yull
YY
Choi
Jung-Hwan
JH
D015415:Biomarkers / Q000097:blood; D001997:Bronchopulmonary Dysplasia / Q000175:diagnosis* / Q000378:metabolism*; D019040:E-Selectin / Q000097:blood / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009504:Neutrophils / Q000378:metabolism; D011237:Predictive Value of Tests; D014132:Trachea / Q000378:metabolism
D015415:Biomarkers; D019040:E-Selectin