Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
Recent preliminary data suggest that vaccination with Alzheimer A beta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-A beta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated A beta 1-42. Immunized monkeys developed anti-A beta titers exceeding 1:1000, and their plasma A beta levels were 5- to 10-fold higher than the plasma A beta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta.
Gandy
Sam
S
Farber Institute for Neurosciences, Thomas Jefferson University, 900 Walnut St, Suite 467, Philadelphia, PA 19107, USA. samgandy@earthlink.net
DeMattos
Ron B
RB
Lemere
Cynthia A
CA
Heppner
Frank L
FL
Leverone
Jodi
J
Aguzzi
Adriano
A
Ershler
William B
WB
Dai
Jinlu
J
Fraser
Paul
P
Hyslop
Peter St George
PS
Holtzman
David M
DM
Walker
Lary C
LC
Keller
Evan T
ET
D016229:Amyloid beta-Peptides / Q000276:immunology* / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation; D004195:Disease Models, Animal; D005260:Female; D007114:Immunization / Q000662:veterinary; D008253:Macaca mulatta; D014612:Vaccines / Q000276:immunology*
D016229:Amyloid beta-Peptides; D014612:Vaccines