Growth hormone replacement for patients with adult onset growth hormone deficiency--what have we learned.
Growth hormone (GH) deficiency is a condition recognized to occur in individuals who have had multiple pituitary hormone deficiencies as a result of pathological processes or neurosurgical interventions. The indications, benefits, and risks of GH replacement therapy will be reviewed with an emphasis on those patients who were adults with the deficiency first emerged. The results of this analysis indicate that, although a measurable improvement can be detected in the patient's quality of life, body composition, and some cardiovascular parameters, the larger questions of long-term benefit and patient selection currently remain unanswered.
Piersanti
Monique
M
Department of Endocrinology, Credit Valley Hospital, Toronto, Ontario, Canada. mpiersanti@hotmail.com
D000328:Adult; D001823:Body Composition / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D004393:Dwarfism, Pituitary / Q000175:diagnosis / Q000188:drug therapy; D020249:Hormone Replacement Therapy / Q000379:methods*; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis / Q000188:drug therapy; D010900:Pituitary Diseases / Q000175:diagnosis / Q000188:drug therapy; D011788:Quality of Life
D019382:Human Growth Hormone