title: A new miniature fiber oxygenator for small animal cardiopulmonary bypass.
abstract: Neurocognitive decline following cardiac surgery is an increasing problem, particularly affecting older patients. The use of cardiopulmonary bypass is a suspected cause. Research into pathophysiology and possible preventive measures requires the use of an animal model. Commercial oxygenators are too large and expensive for use in small animals. We describe a fiber oxygenator scaled for use in the rat. In vitro and in vivo testing show that it is able to support full gas exchange in this size of animal, and causes no allergic or toxic reactions.
authors.affiliation: Department of Anesthesiology, E03.511, University Medical Center Utrecht, Heidelberglaan 100, NL-3584CX Utrecht, The Netherlands. rjfhouston@iee.org
authors.forename: Ralph J F
authors.initials: RJ
authors.lastname: Houston
authors.forename: Fellery
authors.initials: F
authors.lastname: de Lange
authors.forename: Cor J
authors.initials: CJ
authors.lastname: Kalkman
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008904:Miniaturization; D023421:Models, Animal; D010102:Oxygen Inhalation Therapy / Q000295:instrumentation; D051381:Rats; D017208:Rats, Wistar