Angular analysis of corpus callosum in 18 patients with frontonasal dysplasia.
Considering the rarity of the frontonasal dysplasia (FD) and the few reports about it in a large casuistry using magnetic resonance image (MRI), we describe the results of the angular analysis of the corpus callosum of 18 individuals with FD (7 male, 11 female), using an easily-reproductive method. Group I had 12 individuals with isolated form and Group II had 6 individuals with FD syndromic with unknown etiology. The results are presented in set. Comparing with the control group, patients with FD presented alpha angle increase and beta and gamma angles reduction (p<0.05). Alpha and gamma angles express the relationship between the anterior portion of corpus callosum and the floor of 4th ventricle. Considering the embryonary development, these findings would occur secondarily to failure during the development of nasal capsula. Thus, angular anomaly in corpus callosum would be a usual finding, and not fortuitous in patients with FD.
Giffoni
Silvyo David Araújo
SD
Departamento de Genética Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.
Gonçalves
Vanda Maria Gimenes
VM
Zanardi
Verônica A
VA
Lopes
Vera Lúcia Gil da Silva
VL
D000015:Abnormalities, Multiple; D000367:Age Factors; D061085:Agenesis of Corpus Callosum; D016022:Case-Control Studies; D002508:Cephalometry; D019465:Craniofacial Abnormalities / Q000175:diagnosis*; D005260:Female; D005624:Frontal Bone / Q000002:abnormalities*; D006801:Humans; D006972:Hypertelorism / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D009295:Nasal Bone / Q000002:abnormalities*; D015203:Reproducibility of Results; D012737:Sex Factors