Influence of age and gender on peri-implant osteogenesis. Age and gender on peri-implant osteogenesis.
Among the local and systemic factors affecting bone repair, great interest is focused on age and gender. The aim of this work was to perform a histomorphometric evaluation of peri-implant bone healing response in male and female rats aged 1 and 3 months. Forty Wistar rats were i.p. anesthetized with xylazine and ketamine. A c.p. Ti implant (Implant Vel, Buenos Aires-Argentina) was placed in the right tibia following the method described by Cabrini et al. (Implant Dent 1993; 2:264-267). Group I: (GI, n = 10) female rats aged 1 month; Group II: (GII, n = 10) female rats aged 3 months; Group III: (GIII, n = 10) male rats aged 1 month; Group IV: (GIV, n = 10) male rats aged 3 months. All the animals were killed by ether overdose 30 days post-implantation. The tibiae were resected, radiographed and embedded in methyl-methacrylate. Ground sections perpendicular to the longer axis of the tibia were obtained and stained with toluidine blue. Percentage of osseointegration and peri-implant bone tissue volume were evaluated. No differences in peri-implant bone tissue histology were observed among groups. No statistically significant differences in peri-implant bone volume and percentage of osseointegration were observed between GII (adult females) and GIV (adult males). Peri-implant bone volume and percentage of osseointegration were markedly greater in GIV (adult males) than in GIII (young males) (14 +/- 1 mm2 and 8 +/- 2 mm2) p < 0.01 and (49 +/- 6% and 24 +/- 9%) p < 0.01 respectively. Using this experimental model, differences in peri-implant osteogenesis (bone volume and percentage of osseointegration) associated to gender were only observed in the young rats, and differences associated to age were found between the groups of males.
Pien
D M
DM
Department of Oral Pathology, School of Dentistry, University of Buenos Aires.
Olmedo
D G
DG
Guglielmotti
M B
MB
D000367:Age Factors; D000818:Animals; D004396:Coloring Agents; D015921:Dental Implants; D005260:Female; D008297:Male; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013977:Tibia / Q000473:pathology / Q000502:physiology; D014048:Tolonium Chloride
D004396:Coloring Agents; D015921:Dental Implants; D014048:Tolonium Chloride