title: Difference in the risk factors for coronary, renal and other peripheral arteriosclerosis in heterozygous familial hypercholesterolemia.
abstract: BACKGROUND
  The aim of the present study was to clarify the risk factors of several types of arteriosclerosis lesions in Japanese individuals with heterozygous familial hypercholesterolemia (FH): renal arteriosclerosis (RAS), abdominal aortic sclerosis (AOS), iliac arteriosclerosis (IAS) and coronary artery disease (CAD).
  
  
  RESULTS
  Coronary angiography (CAG) and abdominal aortic angiography (AAA) were performed in 117 consecutive heterozygous FH subjects (79 men, 38 women; age 22-76). RAS (stenotic lesion or aneurysm) was observed in 39 cases (33%), predominantly in the proximal portion (74%) and both sides equally (right/left = 27/23). Most cases of RAS (64%) presented with <25% stenosis. The differences in the contributing risk factors for the progression and development of RAS, AOS, IAS and CAD in FH were then analyzed. Multiple logistic regression analyses showed independent risk factors for formation of atherosclerosis in each artery were: age alone for RAS; age and plasma low-density lipoprotein cholesterol (LDL-C) for AOS; age, LDL-C and high-density lipoprotein cholesterol (HDL-C) for IAS; and HDL-C and diabetes mellitus for CAD.
  
  
  CONCLUSIONS
  In Japanese subjects with heterozygous FH, there are distinct risk factors for the development and progression of atherosclerosis in the renal, iliac, abdominal aorta, and coronary arteries.
authors.affiliation: Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
authors.forename: Kunimasa
authors.initials: K
authors.lastname: Yagi
authors.forename: Senshu
authors.initials: S
authors.lastname: Hifumi
authors.forename: Atushi
authors.initials: A
authors.lastname: Nohara
authors.forename: Toshinori
authors.initials: T
authors.lastname: Higashikata
authors.forename: Akihiro
authors.initials: A
authors.lastname: Inazu
authors.forename: Kiyo-O
authors.initials: KO
authors.lastname: Mizuno
authors.forename: Masanobu
authors.initials: M
authors.lastname: Namura
authors.forename: Kosei
authors.initials: K
authors.lastname: Ueda
authors.forename: Junji
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Masami
authors.initials: M
authors.lastname: Shimizu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mabuchi
mesh_terms: D001161:Arteriosclerosis / Q000453:epidemiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology; D005260:Female; D006580:Genetic Carrier Screening; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides