title: Nosocomial invasive aspergillosis in a heart transplant patient acquired during a break in the HEPA air filtration system.
abstract: We report a case of nosocomially acquired invasive aspergillosis (IA) in a low-risk heart transplant recipient due to a break in the air conditioning system. A high overload of Aspergillus spores in the intensive care unit room led this patient to acquire IA. Identical environmental and patient isolates allowed our hypothesis to be confirmed and a very precise incubation time to be estimated.
authors.affiliation: Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, 28007 Madrid, Spain. pmunoz@micro.hggm.es
authors.forename: P
authors.initials: P
authors.lastname: Muñoz
authors.forename: J
authors.initials: J
authors.lastname: Guinea
authors.forename: T
authors.initials: T
authors.lastname: Peláez
authors.forename: C
authors.initials: C
authors.lastname: Durán
authors.forename: J L
authors.initials: JL
authors.lastname: Blanco
authors.forename: E
authors.initials: E
authors.lastname: Bouza
mesh_terms: D000389:Air Conditioning; D000391:Air Microbiology; D001228:Aspergillosis / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D003428:Cross Infection / Q000382:microbiology*; D004868:Equipment Failure; D005374:Filtration / Q000295:instrumentation; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D013172:Spores, Fungal / Q000302:isolation & purification