Adverse ocular drug reactions recently identified by the National Registry of Drug-Induced Ocular Side Effects.
OBJECTIVE
To report recent ocular adverse drug reactions identified by the National Registry of Drug-Induced Ocular Side Effects.


METHODS
Case reports from the National Registry and the World Health Organization were collected and adverse drug reactions categorized as follows: certain, probable/likely, possible, unlikely, and conditional/unclassifiable.


RESULTS
Bisphosphonates are associated with ocular inflammation, including the first reports of drug-related scleritis. Topiramate is shown to cause angle-closure glaucoma. Cetirizine can cause an oculogyric crisis, and there is strong evidence retinoids cause intracranial hypertension.


CONCLUSIONS
Recent reports to the National Registry have led to identification of new ocular adverse drug reactions.
Fraunfelder
F W
FW
Casey Eye Institute, Oregon Health and Science University, Portland, Oregon 97239, USA. eyedrug@ohsu.edu
Fraunfelder
F T
FT
D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D000368:Aged; D017332:Cetirizine / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D004164:Diphosphonates / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D005123:Eye / Q000187:drug effects*; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000009:adverse effects; D012042:Registries / Q000706:statistics & numerical data*; D012176:Retinoids / Q000009:adverse effects; D000077236:Topiramate; D014481:United States; D014486:United States Food and Drug Administration; D014944:World Health Organization
D004164:Diphosphonates; D009883:Ophthalmic Solutions; D012176:Retinoids; D000077236:Topiramate; D005632:Fructose; D017332:Cetirizine