title: [A case of MPO-ANCA-related vasculitis after asbestos exposure with progression of a renal lesion after improvement of interstitial pneumonia].
abstract: A 72-year-old woman was admitted complaining of productive cough. She had worked for an asbestos factory for twenty years. She was positive for MPO-ANCA. The chest HRCT showed interstitial pneumonia without any UIP pattern. A specimen obtained by video-assisted thoracoscopic lung biopsy revealed chronic interstitial pneumonia associated with an asbestos body. Although the interstitial pneumonia improved after the administration of a corticosteroid and an immunosuppressive agent, hematuria and renal dysfunction developed about nine months later. The serum MPO-ANCA titer was elevated and the renal biopsy specimen revealed the presence of vasculitis. As the interstitial pneumonia improved after this treatment, the correct diagnosis may have been, not asbestosis, but MPO-ANCA-related interstitial pneumonia.
authors.affiliation: Department of Respiratory Medicine, Tenri Hospital 200 Mishimacho, Tenri, Nara 632-8552, Japan.
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Inoue
authors.forename: Eisaku
authors.initials: E
authors.lastname: Tanaka
authors.forename: Terufumi
authors.initials: T
authors.lastname: Kato
authors.forename: Minoru
authors.initials: M
authors.lastname: Sakuramoto
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Minakuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Maeda
authors.forename: Ko
authors.initials: K
authors.lastname: Maniwa
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Terada
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Goto
authors.forename: Tomoshi
authors.initials: T
authors.lastname: Takeda
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yuba
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Kobashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Noma
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Taguchi
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001195:Asbestosis / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000276:immunology*; D016273:Occupational Exposure; D009195:Peroxidase / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase