title: Primary omental gamma/delta T-cell lymphoma involving the central nervous system.
abstract: Gamma/delta T-cell lymphoma (GDTL) is an uncommon lymphoma that was initially reported to involve only the liver and spleen. GDTL other than the hepatosplenic type is extremely rare. Frequent primary sites include skin and subcutaneous tissue, intestine, or nasal region. We report a case of GDTL of the omentum in a 54 year-old-man. The tumor cells are CD2-, CD3+, CD4-, CD5-, CD8+, CD56+, TIA-1+, granzyme B+/-. They expressed the identical phenotype of intestinal GDTL. The patient was treated with 2 courses of CHOP which comprised cyclophosphamide, doxorubicin, vincristine and prednisolone, and 3 courses of EPOCH which comprised etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin. However, he failed to obtain remission. During the fourth course of EPOCH, muscle weakness of the lower extremities developed and intracranial masses were observed by computed tomographic scan of the brain. Dissemination of lymphoma to the central nervous system was considered and it may be attributable to the expression of CD56 in this case. High dose methotrexate (HD-MTX) chemotherapy successfully eliminated the omental tumor and reduced the size of the intracranial masses, thus HD-MTX appears to be an effective treatment against GDTL.
authors.affiliation: The Third Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan. yharada@tokyo-med.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Komiya
authors.forename: T
authors.initials: T
authors.lastname: Shirota
authors.forename: K
authors.initials: K
authors.lastname: Mukai
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D002490:Central Nervous System / Q000473:pathology*; D006801:Humans; D007564:Japan; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009852:Omentum / Q000473:pathology*; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed