title: [A case of invasive group A Streptococcus infection which was successfully treated with linezolid].
abstract: A 53-year-old male was admitted to our hospital with a high fever and pain in the right arm. He was diagnosed as toxic shock-like syndrome by Streptococcus pyogenes. His arm was amputated because of necrotizing myositis and his renal damage was severe, he was treated in the intensive care unit with continuous hemodiafiltration. Bacteria were isolated from blood, ascites, pleural effusion, skin, and muscle. He was treated with a large amount of ampicillin, clindamycin, and gammaglobulin. However, his general status became worse. His illness improved after linezolid was administered. The reason for the success in treatment with linezolid, which was the inhibitory effect on bacterial toxin and its excellent penetration into the tissue.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ohno
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Higashiyama
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Youichi
authors.initials: Y
authors.lastname: Hirakata
authors.forename: Kszunori
authors.initials: K
authors.lastname: Tomono
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy; D023303:Oxazolidinones / Q000627:therapeutic use*; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000302:isolation & purification
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid