title: Does massive proximal small bowel resection influence prostaglandin E2 synthesis in the stomach and ileum during adaptive process in rats?
abstract: It is unclear whether massive small bowel resection (SBR) affects prostaglandin E2 synthesis in the gastrointestinal tracts. Thus the aim of this study was to investigate possible changes over tissue levels of prostaglandin E2 in the stomach and ileum after massive proximal SBR. Female Swiss-Albino rats underwent control operation (groups 1, 3, 5) or an 80% SBR (groups 2, 4, 6). The specimens were obtained during relaparotomy at 3 days in groups 1 and 2, at 9 days in groups 3 and 4, at 15 days in groups 5 and 6. Group 2 vs. groups 1 and 6, group 4 vs. groups 3 and 6 had significant increase in the levels of gastric acid (P < 0.01, P < 0.05, respectively). Gastric prostaglandin E2 levels markedly increased in group 2 compared to group 1 (P < 0.01). Ileal prostaglandin E2 levels showed to be significantly higher in group 6 when compared with groups 2, 4, and 5 (P < 0.05). Gastric acidity increased at 3 and 9 days, decreased thereafter at 15 days following massive proximal SBR. While resected rats had increased levels of gastric prostaglandin E2 at 3 days, ileal prostaglandin E2 was markedly elevated at 15 days. Therefore, we conclude that prostaglandin E2 may have a possible role in regulating intestinal adaptation at the end of the adaptive process, and contribute to cytoprotective barrier function in the ileum and stomach at early and late periods of the intestinal adaptation, respectively.
authors.affiliation: Pediatric Surgery, Akdeniz University School of Medicine, Antalya, Turkey. adnanaslan@akdeniz.edu.tr
authors.forename: Adnan
authors.initials: A
authors.lastname: Aslan
authors.forename: Nimet
authors.initials: N
authors.lastname: Izgut-Uysal
authors.forename: Cem
authors.initials: C
authors.lastname: Boneval
authors.forename: Mustafa
authors.initials: M
authors.lastname: Melikoglu
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D013505:Digestive System Surgical Procedures; D015232:Dinoprostone / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism / Q000502:physiology / Q000601:surgery; D007082:Ileum / Q000378:metabolism / Q000502:physiology* / Q000601:surgery; D007413:Intestinal Mucosa / Q000502:physiology* / Q000601:surgery; D007421:Intestine, Small / Q000502:physiology* / Q000601:surgery; D051381:Rats; D013270:Stomach / Q000502:physiology* / Q000601:surgery
chemical_list: D015232:Dinoprostone