Movement-related and preparatory activity in the reticulospinal system of the monkey.
Three monkeys ( M. fascicularis) performed a center-out, two-dimensional reaching task that included an instructed delay interval based on a color-coded visuospatial cue. Neural activity in the medial pontomedullary reticular formation (mPMRF) was recorded along with hand movement. Of 176 neurons with movement-related activity, 109 (62%) had movement-related but not preparatory activity (M cells), and 67 (38%) had both movement-related and preparatory activity (MP cells). EOG analyses indicated that the preparatory activity was not consistent with control of eye movements. There were slight changes in electromyograms (EMG) late in the instructed delay period before the Go cue, but these were small compared with the movement-related EMG activity. Preparatory activity, like the EMG activity, was also confined to the end of the instructed delay period for 14 MP cells, but the remaining 53 MP cells (30%) had preparatory activity that was not reflected in the EMG. Peri-movement neural activity varied with movement direction for 70% of the cells, but this variation rarely fit circular statistics commonly used for studies of directional tuning; directional tuning was even less common in the preparatory activity. These data show that neurons in the mPMRF are strongly modulated during small reaching movements, but this modulation was rarely correlated with the trajectory of the hand. In accord with findings in the literature from other regions of the CNS, evidence of activity related to motor preparation in these cells indicates that this function is distributed in the nervous system and is not a feature limited to the cerebral cortex.
Buford
John A
JA
Division of Physical Therapy, School of Allied Medical Professions, The Ohio State University, 1583 Perry Street, Rm 516G, Columbus, OH 43210, USA. Buford.5@osu.edu
Davidson
Adam G
AG
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal; D001696:Biomechanical Phenomena; D003463:Cues; D004576:Electromyography / Q000379:methods; D004585:Electrooculography / Q000379:methods; D005071:Evoked Potentials / Q000502:physiology*; D006225:Hand / Q000502:physiology; D008252:Macaca fascicularis; D008297:Male; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000145:classification / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D012154:Reticular Formation / Q000166:cytology* / Q000502:physiology; D013997:Time Factors; D013998:Time Perception / Q000502:physiology*