[Endothelin system and inhalation of iloprost in pulmonary hypertension].
The haemodynamics and vascular proliferation (remodelling) in pulmonary hypertension are unfavourably affected by a malfunction of the endothelial cells of the pulmonary vessels. A characteristic result is reduced formation of endothelial dilators and increased formation of vasoconstrictors. The favourable effects of a blockade of the endothelin (ET) system with receptor antagonists suggest that the increased formation and limited clearance of ET-1 reaches pathogenetic significance. The therapeutic effects of inhaled iloprost on right cardiac haemodynamics and clinical course, could in addition to the direct vasodilatory effect, also be considered to have a favourable influence on the ET system as a pathophysiologically effective mediator system.
Bauer
M
M
Klinik für Anaesthesiologie und Intensivmedizin, Universitätskliniken des Saarlandes, Homburg/Saar. michael.bauer@med.uni-jena.de
Wilkens
H
H
D000280:Administration, Inhalation; D016232:Endothelins / Q000502:physiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology*; D016285:Iloprost / Q000008:administration & dosage / Q000627:therapeutic use*; D011453:Prostaglandins / Q000502:physiology; D017466:Receptors, Endothelin / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D016232:Endothelins; D011453:Prostaglandins; D017466:Receptors, Endothelin; D014665:Vasodilator Agents; D016285:Iloprost