title: Glycosphingolipids in endocytic membrane transport.
abstract: Endocytosis leads to the internalisation of both lipids and proteins and their delivery to specific subcellular locations. This involves sorting processes that are not completely understood, but may involve interactions between lipids and proteins as well as pH and calcium gradients. This article discusses the importance of endocytosis in glycosphingolipid (GSL) synthesis as well as the potential roles of GSLs in endocytic membrane transport. Although the accumulation of GSLs in storage diseases clearly disrupts endocytic transport, increasing evidence also supports a role for GSLs in endocytosis in normal cells.
authors.affiliation: Department of Biochemistry, Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Sillence
authors.forename: Frances M
authors.initials: FM
authors.lastname: Platt
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D006028:Glycosphingolipids / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D013106:Sphingolipidoses / Q000209:etiology / Q000378:metabolism
chemical_list: D006028:Glycosphingolipids; D002118:Calcium