Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.
Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
Ho
Hoi-Por
HP
Department of Pharmacology, Göteborg University, P.O.B. 431, SE 405 30 Göteborg, Sweden.
Westberg
Lars
L
Annerbrink
Kristina
K
Olsson
Marie
M
Melke
Jonas
J
Nilsson
Staffan
S
Baghaei
Fariba
F
Rosmond
Roland
R
Holm
Göran
G
Björntorp
Per
P
Andersch
Sven
S
Allgulander
Christer
C
Eriksson
Elias
E
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
D011980:Receptors, Progesterone