title: Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures.
abstract: Two new and four known phloroglucinol derivatives were isolated from the dichloromethane extract of the Greek endemic plant Hypericum jovis. Their antioxidant activity was evaluated in vitro with the DPPH assay and in cell cultures using the DCFH-DA assay. All six compounds demonstrated significant antioxidant activity, while two of them possessed activity at a cellular level comparable to Trolox, protecting against ROS.
authors.affiliation: Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771 Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Athanasas
authors.forename: Prokopios
authors.initials: P
authors.lastname: Magiatis
authors.forename: Nikolas
authors.initials: N
authors.lastname: Fokialakis
authors.forename: Alexios-Leandros
authors.initials: AL
authors.lastname: Skaltsounis
authors.forename: Harris
authors.initials: H
authors.lastname: Pratsinis
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kletsas
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds; D002478:Cells, Cultured; D002839:Chromans / Q000494:pharmacology; D016166:Free Radical Scavengers; D006115:Greece; D020902:Hypericum / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010851:Picrates / Q000493:pharmacokinetics; D010946:Plants, Medicinal / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D002839:Chromans; D016166:Free Radical Scavengers; D010851:Picrates; D017382:Reactive Oxygen Species; C487917:hyperjovinol A; C487918:hyperjovinol B; C004931:1,1-diphenyl-2-picrylhydrazyl; D010696:Phloroglucinol; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid