title: Distribution of 99mTc-labeled lymphocytes in control and inflamed rats.
abstract: We studied the in vivo fate of CD8(+) lymphocytes, of naive (CD8(+)CD45RC(bright)) or memory (CD8(+)CD45RC(dim)) phenotype, injected in syngeneic rats, after their sorting and labeling with [(99m)Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8(+) lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.
authors.affiliation: Istituto di Patologia Generale, Universita degli Studi di Milano, Milano, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fulgenzi
authors.forename: Rosangela
authors.initials: R
authors.lastname: Casati
authors.forename: Fabio Riccardo
authors.initials: FR
authors.lastname: Colombo
authors.forename: Massimo
authors.initials: M
authors.lastname: Gasparini
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ferrero
authors.forename: Attilio
authors.initials: A
authors.lastname: Bondanza
authors.forename: Paolo
authors.initials: P
authors.lastname: Gerundini
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Ferrero
mesh_terms: D000818:Animals; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008214:Lymphocytes / Q000000981:diagnostic imaging*; D008297:Male; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D019690:Technetium Tc 99m Exametazime / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime