Feeding response to a potent prolactin-releasing peptide agonist in lean and obese Zucker rats.
Prolactin (PRL)-releasing peptide (PrRP) is a new peptide present in the hypothalamus and in the circulation that may be involved in the regulation of feeding behavior. In the present experiment, we measured it in a well-known model of obesity, the Zucker rat. We also measured the reactivity of this animal in terms of food intake after the intraperitoneal (I.P.) or central injection of PrRP-13, a potent PrRP agonist. Plasma PrRP levels were 35% lower in obese fa/fa than in the lean rats (p<0.005). I.P. injections of PrRP-13 (10 mg/kg) stimulated food intake in lean and had no effect in obese rats (p<0.001). Intracerebral injections of PrRP-13 had no effects in both genotypes. Altogether, these results do not support a role for PrRP in the hyperphagia and obesity syndrome of the Zucker rat.
Beck
Bernard
B
UHP EA 3453/IFR 111-Systèmes Neuromodulateurs des Comportements Ingestifs-38, rue Lionnois 54000 Nancy, France.
Max
Jean-Pierre
JP
Richy
Sébastien
S
Stricker-Krongrad
Alain
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D007028:Hypothalamic Hormones / Q000097:blood / Q000494:pharmacology*; D020738:Leptin / Q000097:blood; D009479:Neuropeptides / Q000097:blood / Q000494:pharmacology*; D009765:Obesity / Q000235:genetics / Q000503:physiopathology*; D010446:Peptide Fragments / Q000097:blood / Q000494:pharmacology; D056690:Prolactin-Releasing Hormone; D051381:Rats; D011924:Rats, Zucker; D013851:Thinness / Q000097:blood / Q000503:physiopathology; D013997:Time Factors
D007028:Hypothalamic Hormones; D020738:Leptin; D009479:Neuropeptides; D010446:Peptide Fragments; C534379:Prlh protein, rat; D056690:Prolactin-Releasing Hormone