[Sentinel lymph node biopsy in colorectal carcinoma].
Lymph node status as an important prognostic factor in colon and rectal cancer is affected by the selection and number of lymph nodes examined and by the quality of histopathological assessment. The multitude of influences is accompanied by an elevated risk of quality alterations. Sentinel lymph node biopsy (SLNB) is currently under investigation for its value in improving determination of the nodal status. Worldwide, the data of 800 to 1000 patients from about 20 relatively small studies are available that focus rather on colon than rectal cancer patients. SLNB may be of clinical value for the collective of patients that are initially node-negative after H&E staining but reveal small micrometastases or isolated tumor cells in the SLN after intensified histopathological workup. If further studies confirm that these patients benefit from adjuvant therapy, the method may have an important effect on the therapy and prognosis of colon cancer patients as well. Another potential application could be the determination of the nodal status after endoscopic excision of early cancer to avoid bowel resection and lymphonodectomy.
Bembenek
A
A
Klinik für Chirurgie und Chirurgische Onkologie, Charité-Universitätsmedizin Berlin, Campus Berlin-Buch, Robert-Rössle-Klinik im HELIOS-Klinikum Berlin, Berlin.
Gretschel
S
S
Ulmer
C
C
Schlag
P M
PM
D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D004396:Coloring Agents; D005188:False Negative Reactions; D005240:Feasibility Studies; D006801:Humans; D010535:Laparoscopy; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D015337:Multicenter Studies as Topic; D011877:Radionuclide Imaging; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery; D012307:Risk Factors; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D013997:Time Factors
D004396:Coloring Agents