title: Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma.
abstract: We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Lemaire
authors.forename: R
authors.initials: R
authors.lastname: Millon
authors.forename: D
authors.initials: D
authors.lastname: Muller
authors.forename: Y
authors.initials: Y
authors.lastname: Rabouel
authors.forename: L
authors.initials: L
authors.lastname: Bracco
authors.forename: J
authors.initials: J
authors.lastname: Abecassis
authors.forename: B
authors.initials: B
authors.lastname: Wasylyk
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D015152:Blotting, Northern; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D016147:Genes, Tumor Suppressor; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D025521:Tumor Suppressor Proteins
chemical_list: D014408:Biomarkers, Tumor; C476884:HOPX protein, human; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins