title: Efficacy of eprinomectin pour-on against gastrointestinal nematodes and the nasal bot fly (Oestrus ovis) in sheep.
abstract: The efficacy of the pour-on formulation of eprinomectin, at a dose rate of 0.5 mg/kg bodyweight, was assessed in sheep against three main species of gastrointestinal nematodes and against the nasal bot fly, Oestrus ovis, and some pharmacokinetic parameters were determined for 21 days after the treatment. By comparison with untreated control sheep, infected experimentally with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis, eprinomectin was 100 per cent effective against the two abomasal species and 99.5 per cent effective against T. colubriformis. In ewes naturally infected with the nasal bot fly, the efficacy of the drug against O. ovis was 97.7 per cent. The mean (se) systemic area under the curve (AUC) was 56.0 (26.2) ng/day/ml and the mean residence time was 5.3 (1.0) days, but there were wide variations between individual sheep.
authors.affiliation: UMR 1225 INRA/DGER, 'Interactions Hôte Agent Pathogènes' 23 Chemin des Capelles, 31076 Toulouse Cedex, France.
authors.forename: H
authors.initials: H
authors.lastname: Hoste
authors.forename: A
authors.initials: A
authors.lastname: Lespine
authors.forename: P
authors.initials: P
authors.lastname: Lemercier
authors.forename: M
authors.initials: M
authors.lastname: Alvinerie
authors.forename: P
authors.initials: P
authors.lastname: Jacquiet
authors.forename: P
authors.initials: P
authors.lastname: Dorchies
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019540:Area Under Curve; D001494:Baths / Q000662:veterinary; D004175:Diptera / Q000469:parasitology; D005243:Feces / Q000469:parasitology; D005260:Female; D007306:Insecticides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D009348:Nematoda / Q000145:classification / Q000472:pathogenicity; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D009668:Nose Diseases / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000871:Anthelmintics; D007306:Insecticides; D007559:Ivermectin; C101434:eprinomectin