The immunoregulatory role of CD1d-restricted natural killer T cells in disease.
Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.
van der Vliet
Hans J J
HJ
The Departments of Pathology, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands.
Molling
Johan W
JW
von Blomberg
B Mary E
BM
Nishi
Nobusuke
N
Kölgen
Wendy
W
van den Eertwegh
Alfons J M
AJ
Pinedo
Herbert M
HM
Giaccone
Giuseppe
G
Scheper
Rik J
RJ
D000276:Adjuvants, Immunologic; D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D055610:Antigens, CD1d; D001327:Autoimmune Diseases / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology; D005699:Galactosylceramides / Q000276:immunology / Q000627:therapeutic use; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007167:Immunotherapy / Q000379:methods; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000276:Adjuvants, Immunologic; D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D005699:Galactosylceramides; C103873:KRN 7000