title: In vivo and in vitro effect of latex of Calotropis procera on gastrointestinal smooth muscles.
abstract: The present study was carried out to evaluate the effect of dry latex (DL) of Calotropis procera on smooth muscles of gastrointestinal tract. Oral administration of DL to rats (50-1000 mg/kg) produced a dose-dependent decrease in intestinal transit along with a decrease in intestinal content as compared to control group. At lower doses DL produced dose-dependent contractions of gastrointestinal smooth muscles in vitro (rabbit ileum and fundus of rat stomach) that was followed by desensitization at higher doses.
authors.affiliation: Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. kumarvl198@hotmail.com
authors.forename: V L
authors.initials: VL
authors.lastname: Kumar
authors.forename: Y M
authors.initials: YM
authors.lastname: Shivkar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D031107:Calotropis; D004064:Digestive System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility / Q000187:drug effects; D007840:Latex / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D051381:Rats; D017208:Rats, Wistar
chemical_list: D007840:Latex