title: Serotonin transporter regulatory region polymorphism is associated with anorexia nervosa.
abstract: Several lines of evidence support possible serotonin transporter (5-HTT) involvement in modulating eating disorders (ED). The 5-HTT gene is a good candidate for genetic studies on the course of ED, despite controversy concerning the association between polymorphism in the 5-HTT gene promoter region (5-HTTLPR) and ED. Comparison of 5-HTTLPR distribution in 195 female Japanese ED patients and 290 age- and gender-matched control subjects facilitated examining the association between the course of the disease and 5-HTTLPR in 138 of 195 ED subjects. The 5-HTTLPR S allele frequency was significantly higher in subjects with anorexia nervosa (AN) than in control subjects. Among subjects observed > or =3 years, the S allele frequency was significantly higher in those diagnosed as AN at ED onset than in those diagnosed as AN in this study. The 5-HTTLPR S allele might play some role in the development of AN with persistent disease.
authors.affiliation: National Institute on Alcoholism, Kurihama National Hospital, 5-3-1 Nobi Yokosuka, Kanagawa 239-0841, Japan.
authors.forename: Sachio
authors.initials: S
authors.lastname: Matsushita
authors.forename: Kenji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masanobu
authors.initials: M
authors.lastname: Murayama
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishiguchi
authors.forename: Akitoyo
authors.initials: A
authors.lastname: Hishimoto
authors.forename: Aya
authors.initials: A
authors.lastname: Takeda
authors.forename: Osamu
authors.initials: O
authors.lastname: Shirakawa
authors.forename: Susumu
authors.initials: S
authors.lastname: Higuchi
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000235:genetics*; D016022:Case-Control Studies; D001068:Feeding and Eating Disorders / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D017720:Molecular Epidemiology; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins
chemical_list: D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins