title: [Effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis].
abstract: OBJECTIVE
  To study the effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis.
  
  
  METHODS
  Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type I and type II(TGFbetaRI, TGFbetaRII) in gastric mucosa were examined by immunohistochemical method.
  
  
  RESULTS
  The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P<0.05); The TGFbetaRI(P=0.16) and TGFbetaRII(P=0.97) were lower.
  
  
  CONCLUSIONS
  Hp infection promotes over  proliferation of gastric mucosal cells.
authors.affiliation: Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China. liuzhengx2003@vip.sina.com
authors.forename: Zheng-xin
authors.initials: ZX
authors.lastname: Liu
authors.forename: Bao-wen
authors.initials: BW
authors.lastname: Chen
authors.forename: Gui-bin
authors.initials: GB
authors.lastname: Yang
authors.forename: Xi-quan
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Bo-qi
authors.initials: BQ
authors.lastname: Jia
mesh_terms: D030201:Activin Receptors, Type I / Q000032:analysis; D000328:Adult; D000368:Aged; D002455:Cell Division; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis; D016481:Helicobacter Infections / Q000378:metabolism / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D018125:Receptors, Transforming Growth Factor beta; D066246:ErbB Receptors; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II