title: Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays.
abstract: Detailed biological studies of methyl- and some ethylimidazolium ionic liquids in luminescent bacteria as well as in the IPC-81 (leukemia cells) and C6 (glioma cells) rat cell lines are presented. Effective concentrations in these test systems are generally some orders of magnitude lower than effective concentrations [corrected] of the conventional solvents acetone, acetonitrile, methanol, and methyl t-butyl ether. No general influence of the anionic compound in the ionic liquids on toxicity could be found, although they seem to modulate toxicity in some cases. The clear influence of the alkyl chain length on toxicity was quantified by linear regression analysis. Alkyl chain length of the longer alkyl chain was varied from 3 to 10 carbon atoms. Consequences for a design of sustainable alternative solvents are briefly sketched.
authors.affiliation: UFT Center for Environmental Research and Environmental Technology, Leobenerstrasse, D-28359 Bremen, Germany. jranke@uni-bremen.de
authors.forename: J
authors.initials: J
authors.lastname: Ranke
authors.forename: K
authors.initials: K
authors.lastname: Mölter
authors.forename: F
authors.initials: F
authors.lastname: Stock
authors.forename: U
authors.initials: U
authors.lastname: Bottin-Weber
authors.forename: J
authors.initials: J
authors.lastname: Poczobutt
authors.forename: J
authors.initials: J
authors.lastname: Hoffmann
authors.forename: B
authors.initials: B
authors.lastname: Ondruschka
authors.forename: J
authors.initials: J
authors.lastname: Filser
authors.forename: B
authors.initials: B
authors.lastname: Jastorff
mesh_terms: D000818:Animals; D002412:Cations; D002460:Cell Line; D045744:Cell Line, Tumor / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000737:chemistry / Q000633:toxicity*; D007202:Indicators and Reagents; D008163:Luminescent Measurements; D051381:Rats; D013778:Tetrazolium Salts; D014733:Vibrio / Q000187:drug effects* / Q000254:growth & development
chemical_list: C110656:2-(4-iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium; D002412:Cations; D007093:Imidazoles; D007202:Indicators and Reagents; D013778:Tetrazolium Salts