title: Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity.
abstract: Twenty-three kaurane-type diterpenes 1 - 23, including twenty new natural products 1 - 20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED (50) values in the range of 10 - 20 microg/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used.
authors.affiliation: Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, Pisa, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Braca
authors.forename: Annahil
authors.initials: A
authors.lastname: Armenise
authors.forename: Ivano
authors.initials: I
authors.lastname: Morelli
authors.forename: Jeannette
authors.initials: J
authors.lastname: Mendez
authors.forename: Qiuwen
authors.initials: Q
authors.lastname: Mi
authors.forename: Hee-Byung
authors.initials: HB
authors.lastname: Chai
authors.forename: Steven M
authors.initials: SM
authors.lastname: Swanson
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
authors.forename: Nunziatina
authors.initials: N
authors.lastname: De Tommasi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D045786:Diterpenes, Kaurane / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D028222:Picea; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045786:Diterpenes, Kaurane; D010936:Plant Extracts