Structural determinants involved in the activation and regulation of G protein-coupled receptors: lessons from the alpha1-adrenegic receptor subtypes.
The aim of a large number of studies on G protein-coupled receptors was centered on understanding the structural basis of their main functional properties. Here, we will briefly review the results obtained on the alpha1-adrenergic receptor subtypes belonging to the rhodopsin-like family of receptors. These findings contribute, on the one hand, to further understand the molecular basis of adrenergic transmission and, on the other, to provide some generalities on the structure-functional relationship of G protein-coupled receptors.
Cotecchia
Susanna
S
Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland. susanna.cotecchia@ipharm.unil.ch
Stanasila
Laura
L
Diviani
Dario
D
Björklöf
Katja
K
Rossier
Olivier
O
Fanelli
Francesca
F
D000595:Amino Acid Sequence; D000818:Animals; D004252:DNA Mutational Analysis; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009154:Mutation; D011485:Protein Binding; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000502:physiology*; D012243:Rhodopsin / Q000378:metabolism
D018340:Receptors, Adrenergic, alpha-1; D043562:Receptors, G-Protein-Coupled; D012243:Rhodopsin