title: Anti-inflammatory cyathane diterpenoids from Sarcodon scabrosus.
abstract: Four novel diterpenoids were isolated from the fruiting bodies of Sarcodon scabrosus (Fr.) Karst. (Boraginaceae) together with neosarcodonin A. One of the novel compounds was elucidated to be a cyathane diterpenoid, namely neosarcodonin O, by its spectral data. The others were characterized as 19-O-linoleoyl, 19-O-oleoyl and 19-O-stearoyl derivatives of sarcodonin A, after comparison with the authentic samples synthetically prepared from sarcodonin A. These compounds, together with the five 19-O-acyl derivatives synthesized from sarcodonin A, each exhibited inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation on mouse ears by topical application.
authors.affiliation: Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Gifu, Japan.
authors.forename: Tsunashi
authors.initials: T
authors.lastname: Kamo
authors.forename: Yuki
authors.initials: Y
authors.lastname: Imura
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hagio
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Makabe
authors.forename: Hisao
authors.initials: H
authors.lastname: Shibata
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hirota
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D028082:Boraginaceae / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D013729:Terpenes
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D013729:Terpenes; C117589:sarcodonin M