[Effects of naloxone, nalorphine and dalargin on the course of shock due to the combination of mechanical trauma and acute blood loss].
Acute experiments on 75 adult rabbits were made to study action of intravenous injections of naloxone (0.1 mg/kg), nalorphine (0.5 and 2.0 mg/kg) and dalargin (0.1 mg/kg) in early and late periods of irreversible shock caused by combination of non-shockogenic mechanical trauma of the hip and safe blood loss from the femoral artery. In early shock antagonists of opiate receptors did not influence the outcomes while injection of dalargin prolonged survival of the animals noticeably. In late shock injection of the drugs had no significant influence on the course of the pathological process while reinfusion did not help the animals to survive. In the late shock injection of the above drugs after blood reinfusion increased the rabbits' survival.
Sherman
D M
DM
Formanchuk
O K
OK
D000818:Animals; D001794:Blood Pressure; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006470:Hemorrhage / Q000150:complications / Q000188:drug therapy; D025981:Hip Injuries / Q000150:complications / Q000188:drug therapy; D009269:Nalorphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011817:Rabbits; D012769:Shock / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D012771:Shock, Hemorrhagic / Q000150:complications / Q000188:drug therapy; D015996:Survival Rate; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000150:complications / Q000188:drug therapy
D009292:Narcotic Antagonists; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; D009269:Nalorphine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-