Large-scale genome remodelling by the developmentally programmed elimination of germ line sequences in the ciliate Paramecium.
In Paramecium, during the development of the somatic macronucleus, precise excision of thousands of single-copy non-coding sequences is initiated by specific DNA double-strand breaks, while imprecise elimination of germ-line-limited repeated sequences leads to internal deletions or chromosome fragmentation. Recent data point to a role of non-coding RNAs in the epigenetic programming of these rearrangements.
Bétermier
Mireille
M
CNRS UMR 8541, Laboratoire de Génétique Moléculaire, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France. betermie@biologie.ens.fr
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D043171:Chromosomal Instability / Q000235:genetics; D004247:DNA; D016054:DNA, Protozoan / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics; D017353:Gene Deletion; D015321:Gene Rearrangement / Q000235:genetics*; D018503:Genome, Protozoan; D010247:Paramecium / Q000235:genetics* / Q000648:ultrastructure; D011123:Polyploidy; D022661:RNA, Untranslated / Q000235:genetics; D017384:Sequence Deletion
D016054:DNA, Protozoan; D022661:RNA, Untranslated; D004247:DNA