title: Assessment of auditory function in rhesus monkeys (Macaca mulatta): effects of age and calorie restriction.
abstract: Age-related alterations in auditory function were evaluated in adult male rhesus monkeys (Macaca mulatta) involved in a long-term study evaluating the effects of caloric restriction (CR) on aging. We assessed 26 monkeys in a control group fed a low fat, high fiber diet at approximately ad libitum levels and 24 monkeys in a CR group that were fed the same diet reduced in amount by 30% compared to age- and weight-matched controls. The following measures of auditory function were obtained while monkeys were maintained under anesthesia: (1) distortion product otoacoustic emissions (DPOAEs); (2) auditory brainstem responses (ABRs); and (3) middle latency responses (MLRs). All DPOAE measures and peak II amplitude significantly decreased with age, while peak IV latency and ABR threshold significantly increased with age. We found no significant effects of CR on any auditory parameters examined.
authors.affiliation: Department of Population Health Services, University of Wisconsin-Madison, WI, USA. ptorre@mail.sdsu.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Torre
authors.forename: Julie A
authors.initials: JA
authors.lastname: Mattison
authors.forename: Cynthia G
authors.initials: CG
authors.lastname: Fowler
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lane
authors.forename: George S
authors.initials: GS
authors.lastname: Roth
authors.forename: Donald K
authors.initials: DK
authors.lastname: Ingram
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001309:Auditory Threshold / Q000502:physiology; D031204:Caloric Restriction; D002149:Energy Intake / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006309:Hearing / Q000502:physiology*; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D016555:Matched-Pair Analysis; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D010469:Perceptual Distortion / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values