title: Microwave-assisted synthesis of 2,4,5-triaryl-imidazole; a novel thermally induced N-hydroxyimidazole N-O bond cleavage.
abstract: [reaction: see text] 2,4,5-Triaryl-imidazoles were synthesized directly from the keto-oxime in moderate to good yields via cyclization to the N-hydroxyimidazole and an unprecedented in situ thermal reduction of the N-O bond upon microwave irradiation at 200 degrees C for 20 min.
authors.affiliation: Discovery Chemistry, Experimental Station, Incyte Corporation, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA.
authors.forename: Richard B
authors.initials: RB
authors.lastname: Sparks
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Combs