title: Effect of influenza vaccinations on immune response and serum eotaxin level in patients with allergic bronchial asthma.
abstract: BACKGROUND
  One of the most promising markers of allergic inflammation is eotaxin, which has a selective influence on the migration of eosinophils. Its serum content significantly correlates with the intensity of allergic symptoms, so it might be interesting to know whether vaccination has any influence on serum expression of this chemokine.
  
  
  OBJECTIVE
  Comparison of the humoral response to influenza vaccine and post-vaccination changes in the serum eotaxin level in patients with allergic bronchial asthma and healthy controls.
  
  
  METHODS
  Forty-two asthmatics and 45 healthy individuals were vaccinated with a single dose of influenza subunit vaccine (Influvac). The serum eotaxin level and the antibody response to haemagglutinin (HI) and neuraminidase (NI) glycoproteins were measured before and after vaccination.
  
  
  RESULTS
  A significant increase of geometric mean titres of HI and NI was observed in both groups. There were no significant differences between the groups in meanfold increase of HI and NI titres, response rate and protective level of HI. After vaccination, a significant decrease of the mean serum eotaxin value was observed in patients with asthma (149.4 +/- 71.0 versus 125.1 +/- 67.0, p= 0.0017), while no similar effect was present in healthy individuals (153.4 +/- 56.9 versus 159.3 +/- 54.4, p= 0.5).
  
  
  CONCLUSIONS
  The results indicate that in patients with allergic bronchial asthma influenza vaccinations assure efficient protective antibody level and modulate the serum level of eotaxin.
authors.affiliation: Department of Internal Medicine, Pneumonology and Allergology, Military Institute of Medicine, 128 Szaserów Street 00-909 Warsaw, Poland. krozyk@poczta.onet.pl
authors.forename: Karina
authors.initials: K
authors.lastname: Jahnz-Rózyk
authors.forename: Lidia B
authors.initials: LB
authors.lastname: Brydak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Targowski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Machała
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Plusa
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000097:blood*; D002631:Chemotactic Factors, Eosinophil / Q000097:blood; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007252:Influenza Vaccines; D008297:Male; D012016:Reference Values; D012141:Respiratory Tract Infections / Q000097:blood / Q000276:immunology
chemical_list: D015415:Biomarkers; C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D007252:Influenza Vaccines