Diverse and potent activities of HGF/SF in skin wound repair.
Genetic studies in the mouse have highlighted essential roles for several growth factors in skin repair and have offered a rationale for their use in therapy. The present study shows that the plasminogen-related growth factor HGF/SF (hepatocyte growth factor/scatter factor) promotes wound repair in homozygous diabetic db/db mice by recruiting neutrophils, monocytes, and mast cells to the wound; by promoting the migration of endothelial cells to the injured area; and by enhancing keratinocyte migration and proliferation. As a result, granulation tissue formation, wound angiogenesis, and re-epithelialization are all increased. The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds.
Bevan
Damon
D
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
Gherardi
Ermanno
E
Fan
Tai-Ping
TP
Edwards
Dylan
D
Warn
Richard
R
D000818:Animals; D004847:Epithelial Cells / Q000187:drug effects; D006097:Granulation Tissue / Q000187:drug effects; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D015603:Keratinocytes / Q000187:drug effects; D008407:Mast Cells / Q000502:physiology; D051379:Mice; D009000:Monocytes / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D020556:Neutrophil Infiltration / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D017228:Hepatocyte Growth Factor