title: A short synthesis of (+/-)-cytisine.
abstract: The synthesis of racemic cytisine has been completed using (i)N-selective alkylation of 6-bromopyridone with bromide and (ii) Pd(0) mediated intramolecular alpha-arylation of lactam as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.
authors.affiliation: School of Chemistry, University of Bristol, Bristol, UKBS8 1TS.
authors.forename: Candice
authors.initials: C
authors.lastname: Botuha
authors.forename: Carl M S
authors.initials: CM
authors.lastname: Galley
authors.forename: Timothy
authors.initials: T
authors.lastname: Gallagher
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001392:Azocines / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009538:Nicotine / Q000819:agonists; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry; D013034:Sparteine / Q000737:chemistry; D000093843:Quinolizidine Alkaloids
chemical_list: D000470:Alkaloids; D001392:Azocines; D009538:Nicotine; D011807:Quinolizines; D013034:Sparteine; C004712:cytisine; D000093843:Quinolizidine Alkaloids