title: Simultaneous osteosarcoma lung metastasis and second primary lung cancer.
abstract: Second malignant neoplasms (SMNs) after treatment of children and adolescent cancers have been extensively studied. Lung cancer as an SMN is rare in all type of primary cancer in children and in osteosarcoma as well. The authors reviewed all cases of osteosarcomas treated at their institution from 1975 to 2000 and found 22 cases of SMN, only 1 involving lung cancer. The authors describe this latter case, a 17-year-old girl with a localized osteosarcoma of the tibia who developed simultaneously lung metastases of osteosarcoma and a primitive lung adenocarcinoma only 18 months from the diagnosis. Lung cancer is unusual in youths as a primary malignancy or as a second primary malignancy. The occurrence of a primitive lung cancer together with lung metastases from osteosarcoma is even more unusual, and examination of all new lung nodules is highly recommended.
authors.affiliation: Chemotherapy, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy. alessandra.longhi@ior.it
authors.forename: Alessandra
authors.initials: A
authors.lastname: Longhi
authors.forename: Franco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Patrizia
authors.initials: P
authors.lastname: Bacchini
authors.forename: Ugo
authors.initials: U
authors.lastname: Albisinni
authors.forename: Ugo
authors.initials: U
authors.lastname: Mercati
authors.forename: Gaetano
authors.initials: G
authors.lastname: Bacci
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000556:secondary*; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012516:Osteosarcoma / Q000556:secondary*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed