Effect of moxonidine on contractile activity of isolated large intestine in mice: role of alpha2-adrenoceptors and Ii-imidazoline receptors.
We studied the ability of moxonidine to interact with alpha2-adrenoceptors and Ii-imidazoline receptors in isolated mouse large intestine. Moxonidine caused contractions of longitudinal muscles in the large intestine, which depended on the dose of this preparation. Pretreatment with yohimbine (alpha2-adrenoceptor antagonist with low affinity for Ii-imidazoline receptors) and efaroxan (Ii-imidazoline receptor antagonist with low affinity for alpha2-adrenoceptors) abolished the effect of moxonidine. Antagonistic activity and relative selectivity of yohimbine and efaroxan suggest that the effects of moxonidine on mouse large intestine are realized via alpha2-adrenoceptors.
Kozaeva
L P
LP
Department of Pharmacology, Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University. lali_k@mail.ru
Korobov
N V
NV
Medvedev
O S
OS
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D054755:Imidazoline Receptors; D066298:In Vitro Techniques; D007420:Intestine, Large / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects* / Q000502:physiology*; D011955:Receptors, Drug / Q000187:drug effects* / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology
D001572:Benzofurans; D007093:Imidazoles; D054755:Imidazoline Receptors; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; C410887:imidazoline I1 receptors; D015016:Yohimbine; C043482:moxonidine; C062597:efaroxan