title: [DNA damages and changes of certain hepatic biochemical indexes in rats exposed to vinyl chloride monomer].
abstract: OBJECTIVE
  To investigate DNA damages of liver cells and lymphocytes of rats exposed to vinyl chloride monomer(VCM), to examine the changes of hepatic function, and certain biochemical indexes.
  
  
  METHODS
  DNA damages were detected by single cell gel electrophoresis (comet assay). The activities of metabolizing enzymes were measured by spectrophotography, and hepatic function was determined by biochemical analyser.
  
  
  RESULTS
  The incidence rates of comet cells in the experimental groups were significantly higher than those of the controls; and the rates of comet cells between liver cells and lymphocytes among the groups were closely correlated.
  
  
  CONCLUSIONS
  VCM could induce DNA damage of liver cells and lymphocytes, where was a dose-effect/response relationship.
authors.affiliation: School of Public Health of Fudan University, Shanghai 200032, China.
authors.forename: Shoumin
authors.initials: S
authors.lastname: Zhu
authors.forename: Aihong
authors.initials: A
authors.lastname: Wang
authors.forename: Guiming
authors.initials: G
authors.lastname: Liu
authors.forename: Zuyue
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000818:Animals; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004587:Electrophoresis, Agar Gel; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity
chemical_list: D014753:Vinyl Compounds; D019392:Cytochrome P-450 CYP2E1; D005982:Glutathione Transferase; D014752:Vinyl Chloride