The G(894)-T(894) polymorphism in the gene for endothelial nitric oxide synthase and blood pressure in lead-exposed workers from Korea.
We evaluated whether the G -T polymorphism in exon 7 of the endothelial nitric oxide synthase (eNOS) gene is associated with blood pressure or modifies the relation between lead dose and blood pressure in 803 lead workers in Korea. A total of 84.9% of individuals were homozygous GG, 14.4% heterozygous GT, and 0.8% homozygous TT. The T allele was not significantly associated with systolic or diastolic blood pressure. The prevalence of hypertension did not differ by T status (OR = 0.82; 95% CI = 0.50-1.37). There was no evidence of effect modification by eNOS genotype on relations of lead dose with blood pressure. These data provide no evidence that the T allele is associated with higher blood pressure or modifies the association of lead dose with blood pressure.
Lustberg
Mark E
ME
Department of Epidemiology and Preventive Medicine, University of Maryland Baltimore, Baltimore, Maryland 21205, USA.
Schwartz
Brian S
BS
Lee
Byung-Kook
BK
Todd
Andrew C
AC
Silbergeld
Ellen K
EK
D000328:Adult; D000483:Alleles; D001794:Blood Pressure / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007723:Korea / Q000453:epidemiology; D007854:Lead / Q000633:toxicity*; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D016273:Occupational Exposure / Q000009:adverse effects; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D011795:Surveys and Questionnaires
D007854:Lead; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III