title: [Study of glycolaldehyde on DNA damage in mouse spleen lymphocytes].
abstract: OBJECTIVE
  Study the effect of glycolaldehyde on DNA of mouse spleen lymphocytes.
  
  
  METHODS
  The DNA damage induced by different concentrations of glycolaldehyde was detected using single cell gel electrophoresis assay (SCGE).
  
  
  RESULTS
  Glycolaldehyde at 0.01 mmol/L could induce lymphocyte DNA strand breakage and DNA damage rate was 8% and, the average migration distance of DNA was (14.32 +/- 2.84) micron. DNA damage rate and the average migration distance of DNA were increased in a concentration-dependent manner.
  
  
  CONCLUSIONS
  glycolaldehyde could induce DNA damage in different concentration in this experiment.
authors.affiliation: Institute of Frontier Medical Science, Jilin University, Changchun 130021, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Liang
authors.forename: Cai
authors.initials: C
authors.lastname: Li
authors.forename: Fangyu
authors.initials: F
authors.lastname: Hou
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000633:toxicity*; D000818:Animals; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology*
chemical_list: D000079:Acetaldehyde; C010972:glycolaldehyde