Control of chemical pattern formation by a clock-and-wavefront type mechanism.
The segmentation of many animals ranging from insects to mammals involves the sequential formation of stationary stripes of gene expression that are perpendicular to the growth axis of the developing embryo. This process has been accounted for by a variety of theoretical "clock-and-wavefront" type models that involve the arrest of an oscillation (the clock) at a moving boundary (the wavefront). Here, we demonstrate experimentally that progressive arrest of a homogeneous oscillation can control the symmetry as well as the wavelength of spatial structures in a chemical system. We show how a spontaneously formed, labyrinthine pattern can be converted into a pattern composed of ordered, parallel stripes and confirm a previously predicted proportionality between the wavelength and the period of the homogeneous oscillation. Our experiments provide the first experimental demonstration of a general mechanism for the control of pattern formation that has been hypothesized to operate in the context of biological morphogenesis.
Kaern
Mads
M
Center for BioDynamics, Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA. mkaern@bu.edu
Míguez
David G
DG
Muñuzuri
Alberto P
AP
Menzinger
Michael
M
D000818:Animals; D001683:Biological Clocks / Q000502:physiology; D019521:Body Patterning / Q000502:physiology*; D008954:Models, Biological