Role of humoral factors in the regulation of hemopoiesis during immobilization stress.
Experiments were performed on CBA/CaLac mice with hyperplasia of hemopoiesis induced by 10-h immobilization. Erythropoietic and colony-stimulating activity increased under the influence of hemopoietic growth factors and other humoral substances, which plays a major role in the increase in bone marrow cellularity during immobilization stress. Erythropoietin stimulated proliferation of erythroid colony-forming units, while granulocyte colony-stimulating factor accelerated maturation of granulocyte precursors.
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Zhdanov
V V
VV
Epstein
O I
OI
Kirienkova
E V
EV
Gol'dberg
E D
ED
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis / Q000502:physiology; D004921:Erythropoietin / Q000037:antagonists & inhibitors / Q000502:physiology; D016179:Granulocyte Colony-Stimulating Factor / Q000037:antagonists & inhibitors / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D007103:Immobilization / Q000009:adverse effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D038042:Myelopoiesis / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology
D000911:Antibodies, Monoclonal; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor