Teaching cancer cells to die.
Tumor cells have evolved numerous mechanisms to thwart apoptosis. As our understanding of the machinery which regulates cell-death evolves, these apoptotic defects have fallen into the crosshairs of cancer drug developers. The issues raised in exploiting these alterations for therapeutic benefit are discussed.
Zawel
Leigh
L
Novartis Institute for Biomedical Research, Oncology Biology, East Hanover, New Jersey 07936, USA. leigh.zawel@pharma.novartis.com
D000818:Animals; D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction