title: Carbohydrate-based therapeutics.
abstract: In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.
authors.affiliation: School of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK. h.m.i.osborn@rdg.ac.uk
authors.forename: Helen M I
authors.initials: HM
authors.lastname: Osborn
authors.forename: Philip G
authors.initials: PG
authors.lastname: Evans
authors.forename: Natasha
authors.initials: N
authors.lastname: Gemmell
authors.forename: Sadie D
authors.initials: SD
authors.lastname: Osborne
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001428:Bacterial Vaccines; D002241:Carbohydrates / Q000096:biosynthesis / Q000276:immunology* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006025:Glycosaminoglycans / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors; D006801:Humans; D037102:Lectins / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000276:immunology
chemical_list: D000890:Anti-Infective Agents; D000911:Antibodies, Monoclonal; D001428:Bacterial Vaccines; D002241:Carbohydrates; D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans; D037102:Lectins; D011135:Polysaccharides, Bacterial; D016695:Glycosyltransferases; D006026:Glycoside Hydrolases