Tubulointerstitial nephritis and uveitis in monozygotic twin boys.
We describe monozygotic male twins who developed tubulointerstitial nephritis and uveitis (TINU) almost 2 years apart. They presented with non-specific symptoms and were noted to have glycosuria and renal impairment. Both children have uveitis. One had biopsy-proven interstitial nephritis and the other had biochemical evidence of transient tubular dysfunction. While the renal parameters improved, they are still under treatment for uveitis. The occurrence of TINU in identical twins at an interval of just under 2 years supports a strong genetic element in the aetiology of this syndrome. We believe this is the first report of male twins with TINU.
Howarth
Lucy
L
Department of Paediatric Nephrology, Southampton General Hospital, Tremona Road, SO 16 6YD, Southampton, UK.
Gilbert
Rodney D
RD
Bass
Paul
P
Deshpande
Pankaj V
PV
D002648:Child; D004200:Diseases in Twins / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis*; D014430:Twins, Monozygotic; D014605:Uveitis / Q000150:complications / Q000175:diagnosis*