title: Bovine spongiform encephalopathy infectivity in greater kudu (Tragelaphus strepsiceros).
abstract: Of all the species exposed naturally to the bovine spongiform encephalopathy (BSE) agent, the greater kudu (Tragelaphus strepsiceros), a nondomesticated bovine from Africa, appears to be the most susceptible to the disease. We present the results of mouse bioassay studies to show that, contrary to findings in cattle with BSE in which the tissue distribution of infectivity is the most limited recorded for any of the transmissible spongiform encephalopathies (TSE), infectivity in greater kudu with BSE is distributed in as wide a range of tissues as occurs in any TSE. BSE agent was also detected in skin, conjunctiva, and salivary gland, tissues in which infectivity has not previously been reported in any naturally occurring TSE. The distribution of infectivity in greater kudu with BSE suggests possible routes for transmission of the disease and highlights the need for further research into the distribution of TSE infectious agents in other host species.
authors.affiliation: Institute of Zoology, Regent's Park, London, United Kingdom. A.Cunningham@ioz.ac.uk
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Cunningham
authors.forename: James K
authors.initials: JK
authors.lastname: Kirkwood
authors.forename: Michael
authors.initials: M
authors.lastname: Dawson
authors.forename: Yvonne I
authors.initials: YI
authors.lastname: Spencer
authors.forename: Robert B
authors.initials: RB
authors.lastname: Green
authors.forename: Gerald A H
authors.initials: GA
authors.lastname: Wells
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D000866:Antelopes; D001681:Biological Assay; D001921:Brain / Q000473:pathology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018620:PrPSc Proteins / Q000302:isolation & purification; D013116:Spinal Cord / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D018620:PrPSc Proteins