Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.
Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of approximately 70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.
Hong
Young-Kwon
YK
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
Foreman
Kimberly
K
Shin
Jay W
JW
Hirakawa
Satoshi
S
Curry
Christine L
CL
Sage
David R
DR
Libermann
Towia
T
Dezube
Bruce J
BJ
Fingeroth
Joyce D
JD
Detmar
Michael
M
D002478:Cells, Cultured; D015536:Down-Regulation; D004727:Endothelium / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D020869:Gene Expression Profiling; D019288:Herpesvirus 8, Human / Q000502:physiology*; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology* / Q000821:virology