title: Interactions between tissue fibroblasts in lymph nodes and Hodgkin/Reed-Sternberg cells.
abstract: Classic Hodgkin's Disease (cHD) is a lymphoid neoplasia characterized by a few malignant Hodgkin and Reed-Sternberg (H-RS) cells embedded in an abundant background of non-tumor cells. In this context, fibrosis is a common morphologic feature of HD lesions, being found more frequently in cHD subtypes. The clinical and histopathologic features of cHD are thought to be largely due to the effects of a wide variety of cytokines and chemokines primarily produced by H-RS cells, as well as by the surrounding reactive component. In the present review, first we propose three mechanisms putatively explaining fibroblast activation and fibrosis in HD: (1) unbalanced production of the pro-fibrogenic Th2 over Th1 cytokines; (2) production of TGF-beta, b-FGF and IL-13 by H-RS cells; (3) activation of fibroblasts by CD40L-expressing cells of the HD microenvironment. Second, we suggest some molecular pathways involving cytokines produced by HD-derived fibroblasts (SCF, IL-7, IL-6) supposedly responsible for H-RS proliferation and rescue from apoptosis. Finally, we describe the role of specific molecules produced by H-RS cells in the regulation of HD-derived fibroblast production of chemokines, in turn involved in T-lymphocytes and recruitment of eosinophils.
authors.affiliation: Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, I.R.C.C.S., Aviano (PN), Italy. daldinucci@cro.it
authors.forename: Donatella
authors.initials: D
authors.lastname: Aldinucci
authors.forename: Debora
authors.initials: D
authors.lastname: Lorenzon
authors.forename: Karin
authors.initials: K
authors.lastname: Olivo
authors.forename: Barbara
authors.initials: B
authors.lastname: Rapanà
authors.forename: Valter
authors.initials: V
authors.lastname: Gattei
mesh_terms: D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology*; D005355:Fibrosis / Q000378:metabolism / Q000473:pathology; D006133:Growth Substances / Q000378:metabolism; D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D016539:Reed-Sternberg Cells / Q000378:metabolism / Q000473:pathology*
chemical_list: D006133:Growth Substances