[Minimal changes nephrotic syndrome associated to penicillamine treatment].
We describe three patients with minimal change nephrotic syndrome associated with penicillamine treatment. Two patients had systemic sclerosis and one had rheumatoid arthritis. Cumulative dose of D-penicillamine was similar in all cases, and nephrotic syndrome appeared after 15-33 months of treatment. The drug was stopped and nephrotic syndrome disappeared in 2-4 months, suggesting a possible causal relationship between penicillamine and minimal change disease.
Basterrechea
M A
MA
Sección de Nefrología, Hospital Universitario de Guadalajara, Departamento de Medicina, Universidad de Alcalá.
de Arriba
G
G
García-Martín
F
F
Sánchez-Heras
M
M
Giménez-Vega
E
E
Sánchez
J
J
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy
D007166:Immunosuppressive Agents; D010396:Penicillamine