title: Daptomycin in vitro susceptibility in European Gram-positive clinical isolates.
abstract: The objective of this study was to determine the activity of daptomycin, a novel lipopeptide, against European Gram-positive isolates (n = 1539). The MIC(90)-values of daptomycin against Staphylococcus aureus isolates was 0.25 mg/L, against Enterococcus faecalis 4 mg/L, against Enterococcus faecium 8 mg/L, 0.25 mg/L against Staphylococcus epidermidis, and 0.25mg/L against Streptococcus pneumoniae. Daptomycin was equally potent against antibiotic-susceptible and resistant strains within a particular species. Based on a breakpoint of 1 mg/L for S. aureus and group A streptococci, all isolates tested were susceptible to daptomycin. Based on a breakpoint of 4 mg/L for vancomcyin-susceptible E. faecalis 99.7% of these isolates were susceptible to daptomycin.
authors.affiliation: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, 3504 GA Utrecht, The Netherlands. a.c.fluit@lab.azu.nl
authors.forename: Ad C
authors.initials: AC
authors.lastname: Fluit
authors.forename: Franz-Joseph
authors.initials: FJ
authors.lastname: Schmitz
authors.forename: Jan
authors.initials: J
authors.lastname: Verhoef
authors.forename: Dana
authors.initials: D
authors.lastname: Milatovic
mesh_terms: D017576:Daptomycin / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000187:drug effects*
chemical_list: D017576:Daptomycin