title: A case of T-cell acute lymphoblastic leukemia after treatment of acute promyelocytic leukemia.
abstract: We diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with multiple cytogenetic abnormalities in a 17-year-old girl a year after she had received a diagnosis of acute promyelocytic leukemia (APML). After the diagnosis of APML in June 2001, the patient was treated with idarubicin and all-trans-retinoic acid. In September 1999, her younger sister also received a diagnosis of APML and to date has remained well. T-ALL after remission of APML is very rare, and only 1 such case has been reported. Possible causes include therapy-related reasons, genetic susceptibility to leukemia, and environmental exposure.
authors.affiliation: Department of Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur, Malaysia. pingchong@email.com
authors.forename: P C
authors.initials: PC
authors.lastname: Bee
authors.forename: G G
authors.initials: GG
authors.lastname: Gan
authors.forename: J V
authors.initials: JV
authors.lastname: Sangkar
authors.forename: A
authors.initials: A
authors.lastname: Teh
authors.forename: K Y
authors.initials: KY
authors.lastname: Goh
mesh_terms: D000293:Adolescent; D020732:Cytogenetic Analysis; D005192:Family Health; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis / Q000188:drug therapy*; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000209:etiology*; D009894:Opportunistic Infections / Q000209:etiology; D035781:Siblings; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D014212:Tretinoin; D015255:Idarubicin