Contiguous stereogenic quaternary carbons: a daunting challenge in natural products synthesis.
One element of structure that invariably increases the difficulty of a chemical synthesis is the presence in the target molecule of contiguous all-carbon quaternary stereocenters. This Perspective will examine the most useful transformations and strategies devised recently for directly assembling this structural unit.
Peterson
Emily A
EA
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
Overman
Larry E
LE
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D003516:Cycloparaffins / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D001688:Biological Products; D003516:Cycloparaffins; D002244:Carbon