LINKER: a web server to generate peptide sequences with extended conformation.
LINKER was developed as an online server to assist biomedical researchers to design linker sequences for constructing functional fusion proteins. The program automatically generates a set of peptide sequences that are known to adopt extended conformations as determined by X-ray crystallography and NMR. In addition to the desired linker sequence length, the web interface provides a number of optional input parameters so that the users may enhance sequence selection based on the requirements of specific applications. The output of LINKER includes a list of peptide sequences with specified length and sequence characteristics. A graphical subroutine was implemented to highlight the chemical features of every linker sequence by hydrophobicity plots. LINKER can be accessed at http://astro.temple.edu/~feng/Servers/BioinformaticServers.htm.
Xue
Fan
F
Department of Chemistry, Temple University, 1901 N 13th Street, Philadelphia, PA 19122, USA.
Gu
Zhong
Z
Feng
Jin-an
JA
D000595:Amino Acid Sequence; D057927:Hydrophobic and Hydrophilic Interactions; D020407:Internet; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000737:chemistry*; D012984:Software; D014584:User-Computer Interface
D010455:Peptides; D011993:Recombinant Fusion Proteins