Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside.
We present a case of a 21-year-old woman suffering from diffuse large B-cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high-dose cytosine-arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed.
Planer
David
D
Department of Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus, PO Box 24035, Jerusalem 91240, Israel. dplaner@md.huji.ac.il
Cukierman
Tali
T
Liebster
Diana
D
Ilsar
Michael
M
Chajek-Shaul
Tova
T
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000188:drug therapy
D003561:Cytarabine