title: Hemostatic markers and the sepsis-related organ failure assessment score in patients with disseminated intravascular coagulation in an intensive care unit.
abstract: We investigated the correlation between disseminated intravascular coagulation (DIC) score and hemostatic parameters and sepsis-related organ failure assessment (SOFA) score with clinical outcome of patients with DIC in an intensive care unit (ICU). The SOFA score was markedly elevated in patients with DIC relative to patients without DIC and significantly higher in non-survivors than in survivors. Abnormalities in almost all hemostatic parameters were significant in patients with DIC, but there was no significant difference in almost all hemostatic parameters between survivors and non-survivors. However, plasma antithrombin (AT) levels were significantly lower in non-survivors than in survivors. Soluble fibrin (SF) and tissue type plasminogen activator (tPA)-plasminogen activator inhibitor-I (PAI-I) complex correlated significantly with the SOFA score, whereas AT levels correlated significantly and negatively with the SOFA score. We conclude that the SOFA score is useful for predicting outcome in DIC patients in the ICU, and that hemostatic parameters, especially plasma AT levels, are also useful markers for organ failure and clinical outcome.
authors.affiliation: Department of Anesthesiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okabayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Wada
authors.forename: Syunsuke
authors.initials: S
authors.lastname: Ohta
authors.forename: Hirosi
authors.initials: H
authors.lastname: Shiku
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nobori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Maruyama
mesh_terms: D000991:Antithrombins / Q000032:analysis; D015415:Biomarkers / Q000097:blood*; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications / Q000401:mortality; D005337:Fibrin / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D007362:Intensive Care Units; D009102:Multiple Organ Failure / Q000150:complications; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D018805:Sepsis / Q000150:complications; D012720:Severity of Illness Index; D010959:Tissue Plasminogen Activator / Q000097:blood
chemical_list: D000991:Antithrombins; D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D005337:Fibrin; D010959:Tissue Plasminogen Activator