title: Effects of raloxifene on mood, sleep, libido and cognitive function in postmenopausal healthy women: a pilot study.
abstract: OBJECTIVE
  To assess the effect of raloxifene (60 mg) on psychological functions.
  
  
  METHODS
  A total of 49 women were enrolled in a 3-month case-control study. Psychological testing was performed at baseline and at the end of 3 months of treatment. On both occasion measurements were repeated twice at 1 week apart. Scores were averaged.
  
  
  RESULTS
  Raloxifene appeared to adversely affect the performance in the letter search test hence to worsen attention (t19 = 3.55, P = 0.002) but it reduced wakening episodes compared with baseline (t19 = 3.33, P = 0.005). Memory improved compared with baseline both in the raloxifene group (t19 = 2.99, P = 0.008) and in the controls (t19 = 4.64, P = 0.003). No significant differences were found in mood, well-being and indices of sexual activity.
  
  
  CONCLUSIONS
  Raloxifene does not appear to adversely affect psychological function such libido, mood and memory. It may worsen attention but it reduces wakening episodes so it may thus improve sleep.
authors.affiliation: Department of Psychology, University of Bologna, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Natale
authors.forename: Paola
authors.initials: P
authors.lastname: Albertazzi
authors.forename: Natalie
authors.initials: N
authors.lastname: Missiroli
authors.forename: Daniela
authors.initials: D
authors.lastname: Pedrini
authors.forename: Matteo
authors.initials: M
authors.lastname: Salgarello
mesh_terms: D000339:Affect; D016022:Case-Control Studies; D003071:Cognition; D005260:Female; D006801:Humans; D007989:Libido; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control* / Q000523:psychology; D010865:Pilot Projects; D020849:Raloxifene Hydrochloride / Q000008:administration & dosage* / Q000009:adverse effects; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage* / Q000009:adverse effects; D011795:Surveys and Questionnaires
chemical_list: D020845:Selective Estrogen Receptor Modulators; D020849:Raloxifene Hydrochloride