Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study.
Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT). Concerning 5-HT1Dbeta autoreceptor gene, also negative results was obtained in the analysis of the haplotypes with transmit. Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population.
Ambrósio
Alda M
AM
Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, 3004-517 Coimbra, Portugal. aldachico@yahoo.com
Kennedy
James L
JL
Macciardi
Fabio
F
Coelho
Isabel
I
Soares
Maria J
MJ
Oliveira
Catarina R
CR
Pato
Carlos N
CN
D017660:Autoreceptors / Q000235:genetics; D005192:Family Health; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D011174:Portugal / Q000453:epidemiology; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D044346:Receptor, Serotonin, 5-HT1D / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*
D017660:Autoreceptors; D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D