[Leukaemia inhibitory factor (LIF): structure and biological activity].
Leukaemia inhibitory factor (LIF) is a multifunctional cytokine, which plays a role in growth-promotion and differentiation, regulates calcium and bone metabolism, induces acute phase proteins and causes cachexia in organisms with neoplastic disorders. Moreover, LIF participates in the induction of inflammation, and therefore represents an important pathogenic factor of many disorders. The multifunctional properties of LIF have become of special interest to investigators from different disciplines of medicine.
Szepietowski
Jacek
J
Katedra i Klinika Dermatologii, Wenerologii i Alergologii Akademii Medycznej we Wrocławiu. jszepiet@derm.am.wroc.pl
Reich
Adam
A
D000209:Acute-Phase Proteins / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002100:Cachexia / Q000209:etiology / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6 / Q000502:physiology*; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000150:complications / Q000473:pathology; D018121:Receptors, Cytokine / Q000378:metabolism; D053606:Receptors, OSM-LIF
D000209:Acute-Phase Proteins; D015850:Interleukin-6; C507837:LIF protein, human; C507840:LIFR protein, human; D053605:Leukemia Inhibitory Factor; D053680:Leukemia Inhibitory Factor Receptor alpha Subunit; D018121:Receptors, Cytokine; D053606:Receptors, OSM-LIF; D002118:Calcium