title: Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.
abstract: Human ASB-17 (Ankyrin Repeat and SOCS Box-containing 17) is a recently identified gene belonging to the ASB family, isolated from testis cDNA library. Human ASB-17 is expressed exclusively in testis among 16 tissues, revealed by Northern blot. Mouse Asb-17 was shown to be expressed from the third week post birth to adult by semi-quantitative RT-PCR analysis. In situ hybridization on frozen sections demonstrated that Asb-17 is expressed in spermatogenic cells in adult mouse, but not in Leydig cell and epididymis in adult mouse. ASB-17 proteins are highly conserved in mammals including human, mouse, rat, Canis familiaris and Macaca fascicularis.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai, People's Republic of China.
authors.forename: J H
authors.initials: JH
authors.lastname: Guo
authors.forename: H
authors.initials: H
authors.lastname: Saiyin
authors.forename: Y H
authors.initials: YH
authors.lastname: Wei
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Bi
authors.forename: L J
authors.initials: LJ
authors.lastname: Ma
authors.forename: G J
authors.initials: GJ
authors.lastname: Zhou
authors.forename: C Q
authors.initials: CQ
authors.lastname: Huang
authors.forename: L
authors.initials: L
authors.lastname: Yu
authors.forename: L
authors.initials: L
authors.lastname: Dai
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D017089:Ankyrin Repeat / Q000235:genetics*; D015152:Blotting, Northern; D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D015723:Gene Library; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D020133:Reverse Transcriptase Polymerase Chain Reaction; D020539:Sequence Analysis, Protein; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins; D013737:Testis / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C434933:Asb1 protein, mouse; D016207:Cytokines; D050826:Suppressor of Cytokine Signaling Proteins