title: Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus.
abstract: Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of approximately 70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.
authors.affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA.
authors.forename: Young-Kwon
authors.initials: YK
authors.lastname: Hong
authors.forename: Kimberly
authors.initials: K
authors.lastname: Foreman
authors.forename: Jay W
authors.initials: JW
authors.lastname: Shin
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirakawa
authors.forename: Christine L
authors.initials: CL
authors.lastname: Curry
authors.forename: David R
authors.initials: DR
authors.lastname: Sage
authors.forename: Towia
authors.initials: T
authors.lastname: Libermann
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Dezube
authors.forename: Joyce D
authors.initials: JD
authors.lastname: Fingeroth
authors.forename: Michael
authors.initials: M
authors.lastname: Detmar
mesh_terms: D002478:Cells, Cultured; D015536:Down-Regulation; D004727:Endothelium / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D020869:Gene Expression Profiling; D019288:Herpesvirus 8, Human / Q000502:physiology*; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology* / Q000821:virology