Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City.
Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing beta -lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta -lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States.
Bradford
Patricia A
PA
Wyeth Research, Pearl River, NY, USA.
Bratu
Simona
S
Urban
Carl
C
Visalli
Melissa
M
Mariano
Noriel
N
Landman
David
D
Rahal
James J
JJ
Brooks
Steven
S
Cebular
Sanda
S
Quale
John
J
D015780:Carbapenems / Q000378:metabolism / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009519:New York City; D018440:beta-Lactam Resistance / Q000502:physiology*; D001618:beta-Lactamases / Q000378:metabolism*
D015780:Carbapenems; C104731:beta-lactamase IRT-2; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases