No association between DUP25 and anxiety disorders.
Gratacos et al. [2001: Cell 106:367-379] described an interstitial duplication dup(15)q24q26 (DUP25) in patients with anxiety disorders; this duplication was found in approximately 90% of patients and in 7% of controls. In order to determine if DUP25 is present in additional individuals susceptible to panic attacks, we tested 44 patients with anxiety disorders, using probes 251c23 and 216c14 mapping in the 15q24 and 15q26 region. We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here.
Henrichsen
Charlotte Neergaard
CN
Division de Génétique Médicale, Hôpitaux Universitaires de Genève, 1 rue Michel Servet 1211, Geneva 4, Switzerland.
Delorme
Richard
R
Boucherie
Maria
M
Marelli
Dominique
D
Baud
Patrick
P
Bellivier
Franck
F
Courtet
Philippe
P
Chabane
Nadia
N
Henry
Chantal
C
Leboyer
Marion
M
Malafosse
Alain
A
Antonarakis
Stylianos E
SE
Dahoun
Sophie
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15; D015342:DNA Probes; D005260:Female; D020440:Gene Duplication; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology
D015342:DNA Probes