title: Prevalence of lower-extremity disease in the US adult population >=40 years of age with and without diabetes: 1999-2000 national health and nutrition examination survey.
abstract: OBJECTIVE
  Although lower-extremity disease (LED), which includes lower-extremity peripheral arterial disease (PAD) and peripheral neuropathy (PN), is disabling and costly, no nationally representative estimates of its prevalence exist. The aim of this study was to examine the prevalence of lower-extremity PAD, PN, and overall LED in the overall U.S. population and among those with and without diagnosed diabetes.
  
  
  METHODS
  The analysis consisted of data for 2873 men and women aged >or=40 years, including 419 with diagnosed diabetes, from the 1999-2000 National Health and Nutrition Examination Survey. The main outcome measures consisted of the prevalence of lower-extremity PAD (defined as ankle-brachial index <0.9), PN (defined as >or=1 insensate area based on monofilament testing), and of any LED (defined as either PAD, PN, or history of foot ulcer or lower-extremity amputations).
  
  
  RESULTS
  Of the U.S. population aged >or=40 years, 4.5% (95% CI 3.4-5.6) have lower-extremity PAD, 14.8% (12.8-16.8) have PN, and 18.7% (15.9-21.4) have any LED. Prevalence of PAD, PN, and overall LED increases steeply with age and is higher (P < 0.05) in non-Hispanic blacks and Mexican Americans than non-Hispanic whites. The prevalence of LEDs is approximately twice as high for individuals with diagnosed diabetes (PAD 9.5% [5.5-13.4]; PN 28.5% [22.0-35.1]; any LED 30.2% [22.1-38.3]) as the overall population.
  
  
  CONCLUSIONS
  LED is common in the U.S. and twice as high among individuals with diagnosed diabetes. These conditions disproportionately affect the elderly, non-Hispanic blacks, and Mexican Americans.
authors.affiliation: Division of Diabetes Translation, Centers for Disease Control and Prevention, Centers for Diseases Control and Prevention, Atlanta, GA 30341, USA. edg7@cdc.gov
authors.forename: Edward W
authors.initials: EW
authors.lastname: Gregg
authors.forename: Paul
authors.initials: P
authors.lastname: Sorlie
authors.forename: Ryne
authors.initials: R
authors.lastname: Paulose-Ram
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Gu
authors.forename: Mark S
authors.initials: MS
authors.lastname: Eberhardt
authors.forename: Michael
authors.initials: M
authors.lastname: Wolz
authors.forename: Vicki
authors.initials: V
authors.lastname: Burt
authors.forename: Lester
authors.initials: L
authors.lastname: Curtin
authors.forename: Michael
authors.initials: M
authors.lastname: Engelgau
authors.forename: Linda
authors.initials: L
authors.lastname: Geiss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003710:Demography; D003929:Diabetic Neuropathies / Q000453:epidemiology*; D005006:Ethnicity; D006306:Health Surveys; D006801:Humans; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000453:epidemiology*; D015995:Prevalence; D014481:United States / Q000453:epidemiology