title: A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica.
abstract: Latrunculeic acid (3), a novel analogue of latrunculin B (2a), was isolated from the Red Sea sponge Negombata magnifica and characterized. Several known compounds were also isolated, including latrunculin B (2a), 15-methoxylatrunculin B (2b), 16-epi-latrunculin B (4), and latrunculin C (5). In contrast to the other members of the latrunculin family, the novel compound 3 is a polyketide devoid of the normal macrocyclic and thiazolidinone rings present in previously identified members of this family.
authors.affiliation: Department of Chemistry and Biochemistry and Institute for Marine Sciences, University of California, Santa Cruz, California 95064, USA.
authors.forename: Boaz
authors.initials: B
authors.lastname: Vilozny
authors.forename: Taro
authors.initials: T
authors.lastname: Amagata
authors.forename: Susan L
authors.initials: SL
authors.lastname: Mooberry
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
mesh_terms: D008841:Actin Cytoskeleton / Q000187:drug effects*; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019156:Indian Ocean; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D053778:Thiazolidines
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D011753:Pyrones; D013844:Thiazoles; D053778:Thiazolidines; C488322:latrunculeic acid; C037068:latrunculin B