Developing novel activity-based fluorescent probes that target different classes of proteases.
In this article, we report the design and synthesis of a group of novel activity-based probes that target different protease sub-classes based on their substrate specificities, rather than their enzymatic mechanisms. The feasibility of our approach has been demonstrated by using representative members of the different protease sub-classes.
Zhu
Qing
Q
Department of Chemistry, National University of Singapore, Singapore.
Girish
Aparna
A
Chattopadhaya
Souvik
S
Yao
Shao Q
SQ
D000577:Amides / Q000737:chemistry; D010450:Endopeptidases / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D040901:Proteomics; D013379:Substrate Specificity
D000577:Amides; D005456:Fluorescent Dyes; D010450:Endopeptidases