The application of functional MRI of memory in temporal lobe epilepsy: a clinical review.
Functional MRI (fMRI) is a useful tool for noninvasively localizing areas in the brain involved in specific cognitive functions. Since its introduction, there has been considerable speculation regarding the role it may play in the presurgical assessment of temporal lobe epilepsy (TLE). This review considers the progress made to date in using fMRI to investigate memory processing in the medial temporal lobe in normal subjects and in those with TLE. Results so far suggest that fMRI will be incorporated into the presurgical assessment of TLE in the coming years to improve definition of eloquent cerebral areas, with the objective of minimizing the adverse cognitive sequelae of anterior temporal lobe resection.
Powell
H W Robert
HW
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College of London and MRI Unit, National Society for Epilepsy, Buckinghamshire, U.K. r.powell@ion.ucl.ac.uk
Koepp
Matthias J
MJ
Richardson
Mark P
MP
Symms
Mark R
MR
Thompson
Pam J
PJ
Duncan
John S
JS
D001931:Brain Mapping; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000523:psychology / Q000601:surgery; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000175:diagnosis / Q000517:prevention & control / Q000523:psychology; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care / Q000379:methods; D013702:Temporal Lobe / Q000502:physiology* / Q000601:surgery