Studies on electrochemical oxidation of azithromycin and its interaction with bovine serum albumin.
A novel nanoparticle film modified electrode has been constructed using a glassy carbon electrode (GCE) coated with a carbon nanotube-dihexadecylphosphate (DHP) film. This modified electrode exhibits an enhanced effectiveness for the oxidation of azithromycin. A method is also described for the evaluation of azithromycin-bovine serum albumin (BSA) interaction. The electrochemical behavior of azithromycin as well as its interaction with BSA at this nanoparticle film electrode has been investigated by cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry and chronocoulometry. The binding number and association constant between azithromycin and bovine serum albumin have been obtained.
Wu
Yunhua
Y
Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Ji
Xiaobo
X
Hu
Shengshui
S
D000818:Animals; D017963:Azithromycin / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D002244:Carbon / Q000737:chemistry*; D002417:Cattle; D004563:Electrochemistry; D004566:Electrodes; D005069:Evaluation Studies as Topic; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*
D012710:Serum Albumin, Bovine; D002244:Carbon; D017963:Azithromycin