[A case of invasive group A Streptococcus infection which was successfully treated with linezolid].
A 53-year-old male was admitted to our hospital with a high fever and pain in the right arm. He was diagnosed as toxic shock-like syndrome by Streptococcus pyogenes. His arm was amputated because of necrotizing myositis and his renal damage was severe, he was treated in the intensive care unit with continuous hemodiafiltration. Bacteria were isolated from blood, ascites, pleural effusion, skin, and muscle. He was treated with a large amount of ampicillin, clindamycin, and gammaglobulin. However, his general status became worse. His illness improved after linezolid was administered. The reason for the success in treatment with linezolid, which was the inhibitory effect on bacterial toxin and its excellent penetration into the tissue.
Nakamura
Shigeki
S
Second Department of Internal Medicine, Nagasaki University Graduate School of Pharmaceutical Sciences.
Yanagihara
Katsunori
K
Kaneko
Yukihiro
Y
Ohno
Hideaki
H
Higashiyama
Yasuhito
Y
Miyazaki
Yoshitsugu
Y
Hirakata
Youichi
Y
Tomono
Kszunori
K
Tashiro
Takayoshi
T
Kohno
Shigeru
S
D000081:Acetamides / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006801:Humans; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000188:drug therapy; D023303:Oxazolidinones / Q000627:therapeutic use*; D013290:Streptococcal Infections / Q000188:drug therapy*; D013297:Streptococcus pyogenes / Q000302:isolation & purification
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid