The transient receptor potential superfamily of ion channels.
ABSTRACT. The transient receptor potential (TRP) superfamily of proteins is cation-selective ion channels with six predicted transmembrane segments and intracellularly localized amino and carboxyl termini. Members of the TRP superfamily are identified on the basis of amino acid sequence and structural similarity and are classified into TRPC, TRPV, TRPM, TRPP, TRPN, and TRPML subfamilies. TRP channels are widespread and have diverse functions, ranging from thermal, tactile, taste, osmolar, and fluid flow sensing to transepithelial Ca2+ and Mg2+ transport. Mutations of TRP proteins produce many renal diseases, including Mg2+ wasting, hypocalcemia, and polycystic kidney diseases. This review focuses on recent advances in the understanding of their functions.
Huang
Chou-Long
CL
Division of Nephrology, Department of Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA. chou-long.huang@utsouthwestern.edu
D000818:Animals; D001692:Biological Transport; D002412:Cations / Q000737:chemistry*; D002455:Cell Division; D006801:Humans; D007473:Ion Channels / Q000737:chemistry*; D007674:Kidney Diseases / Q000235:genetics / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D005810:Multigene Family; D009154:Mutation; D010802:Phylogeny; D017434:Protein Structure, Tertiary
D002412:Cations; D007473:Ion Channels; D008274:Magnesium