title: Effects of chronic and acute training on glucocorticoid receptors concentrations in rats.
abstract: The effects of chronic endurance training and acute exercise on glucocorticoid receptors were investigated in rats. For chronic endurance training, rats were exposed to progressive running training on a motor-driven treadmill for 3, 5 and 7 weeks, twice a day and 6 days a week. The samples were taken, 34-36 hours after the last exercise bout. Some of the 7-week training rats were killed by decapitation 7 days following the last exercise bout. The glucocorticoid receptors in hepatic cytosol in 5-week and 7-week rats decreased as compared to the sedentary control. There was no significant difference between the glucocorticoid receptors in hepatic cytosol in some of the 7-week rats those who had stopped training for 7 days and those in the controls. The chronic endurance training did not lead to change of the apparent dissociation constant (Kd). The changes of glucocorticoid receptors after acute exercise have also been investigated and it showed profound decreases of glucocorticoid receptors in renal and myocardial cytosol in low intensity (swimming without an extra weight for 60 minutes) and high intensity (swimming with a weight equal to 6% of body mass for 60 minutes) training groups. The decreases in glucocorticoid receptors in renal and myocardial cytosol were less prominent after low intensity training. These results demonstrated that both acute exercise training and chronic endurance training could lead to a decrease in glucocorticoid receptors, which was in a training intensity- and training load volume-dependent manner, and the changes in glucocorticoid receptors during exercise training were reversible.
authors.affiliation: Department of Sports Medicine, Shanghai Institute of Physical Education, Shanghai 200438, China. chengpjk@online.sh.cn
authors.forename: Chen
authors.initials: C
authors.lastname: Peijie
authors.forename: Duan
authors.initials: D
authors.lastname: Zicai
authors.forename: Xu
authors.initials: X
authors.lastname: Haowen
authors.forename: Xu
authors.initials: X
authors.lastname: Renbao
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011965:Receptors, Glucocorticoid