title: ADVICE: Automated Detection and Validation of Interaction by Co-Evolution.
abstract: ADVICE (Automated Detection and Validation of Interaction by Co-Evolution) is a web tool for predicting and validating protein-protein interactions using the observed co-evolution between interacting proteins. Interacting proteins are known to share similar evolutionary histories since they undergo coordinated evolutionary changes to preserve interactions and functionalities. The web tool automates a commonly adopted methodology to quantify the similarities in proteins' evolutionary histories for postulating potential protein-protein interactions. ADVICE can also be used to validate experimental data against spurious protein interactions by identifying those that have few similarities in their evolutionary histories. The web tool accepts a list of protein sequences or sequence pairs as input and retrieves orthologous sequences to compute the similarities in the proteins' evolutionary histories. To facilitate hypothesis generation, detected co-evolved proteins can be visualized as a network at the website. ADVICE is available at http://advice.i2r.a-star.edu.sg.
authors.affiliation: Knowledge Discovery Department, Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613, Singapore. soonheng@i2r.a-star.edu.sg
authors.forename: Soon-Heng
authors.initials: SH
authors.lastname: Tan
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
authors.forename: See-Kiong
authors.initials: SK
authors.lastname: Ng
mesh_terms: D019143:Evolution, Molecular; D020407:Internet; D025941:Protein Interaction Mapping; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D015203:Reproducibility of Results; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid; D012984:Software; D014584:User-Computer Interface
chemical_list: D011506:Proteins