title: Omeprazole and talampanel as two examples of retrometabolic drug design.
abstract: The goal of retrometabolic drug design is: "to design safe, locally active compounds with an improved therapeutic index". Here we describe two cases from our own practice, talampanel and omeprazole.
authors.affiliation: IVAX Drug Research Institute, Budapest, Hungary.
authors.forename: F
authors.initials: F
authors.lastname: Andrási
authors.forename: P
authors.initials: P
authors.lastname: Berzsenyi
authors.forename: L
authors.initials: L
authors.lastname: Farkas
authors.forename: J
authors.initials: J
authors.lastname: Körösi
authors.forename: T
authors.initials: T
authors.lastname: Hámori
authors.forename: P
authors.initials: P
authors.lastname: Botka
authors.forename: I
authors.initials: I
authors.lastname: Ling
authors.forename: T
authors.initials: T
authors.lastname: Láng
mesh_terms: D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D007202:Indicators and Reagents; D009853:Omeprazole / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D054328:Proton Pump Inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D054328:Proton Pump Inhibitors; C061950:GYKI 52466; D001569:Benzodiazepines; C085266:talampanel; D009853:Omeprazole