title: Percutaneous sclerotherapy of renal cysts with a beta-emitting radionuclide, holmium-166-chitosan complex.
abstract: OBJECTIVE
  To evaluate the usefulness of a beta-emitting radionuclide (holmium-166-chitosan complex) as a sclerosing agent for the treatment of renal cysts.
  
  
  METHODS
  Using 10-30 mCi of holmium-166-chitosan complex, 20 renal cysts in 17 patients (14 male and 3 female patients, ranging in age from 47 to 82 years) were treated by percutaneous sclerotherapy under ultrasonographic guidance. The volume of the cysts before and after the sclerotherapy and the percentage change in volume were calculated in order to evaluate the response to therapy, which was classified as either complete regression (invisible), nearly complete regression (< 15 volume% of initial volume), partial regression (15-50 volume%) or no regression (> 50 volume%).
  
  
  RESULTS
  The follow-up period ranged from 6 to 36 months (mean 28 months). Eighteen cysts (90%) regressed completely (n=11, 55%) or near-completely (n=7, 35%). Partial regression was obtained in one patient (5%) and there was no regression in one patient (5%). No significant complications were encountered.
  
  
  CONCLUSIONS
  The holmium-166-chitosan complex seems to be useful as a new painless sclerosing agent for the treatment of renal cysts with no significant complications.
authors.affiliation: Department of Diagnostic Radiology, Research Institute of Radiological Science, Seoul, Republic of Korea. jtlee@yumc.yonsei.ac.kr
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Jong Tae
authors.initials: JT
authors.lastname: Lee
authors.forename: Eun Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Jong Yoon
authors.initials: JY
authors.lastname: Won
authors.forename: Myeong-Jin
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jong Doo
authors.initials: JD
authors.lastname: Lee
authors.forename: Sung Joon
authors.initials: SJ
authors.lastname: Hong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002686:Chitin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006695:Holmium / Q000627:therapeutic use*; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D015911:Sclerotherapy
chemical_list: C116411:DW 166HC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D002686:Chitin; D006695:Holmium