Dental alveolar bone defects related to Vitamin D and calcium status.
Vitamin D is important for skeletal development, growth, and homeostasis but has been sparsely studied in the oro-facial bone. Dental alveolar bone anchors teeth to mandible and maxilla bones via a periodontal ligament. Its formation and maintenance are strictly dependent on the presence of tooth organs and it is characterized by a high turnover rate. In order to study the role of Vitamin D and the calcium status on dental alveolar bone formation, microradiographic and histologic comparison of wild-type, Vitamin D receptor null mutant (VDR (-/-) hypo- and normo-calcemic mice and tissues were performed at 2 months. In hypo-calcemic VDR (-/-) mice, alveolar bone was hypomineralized and demonstrated a cellular and matrix organization, similar to the immature woven bone. In normo-calcemic VDR (-/-) mice, mineralization of dental alveolar bone appeared normal, but bone was morphologically abnormal in some specific anatomical locations. These data show that Vitamin D and calcium status may control the formation of dental alveolar bone. The differences of phenotype between hypo- and normo-calcemic VDR null mutant mice suggested a specific Vitamin D control of alveolar bone formation by the Vitamin D nuclear receptor pathway.
Davideau
J L
JL
Laboratoire de Biologie Orofaciale et Pathologie INSERM E110, Institut des Cordeliers, Université Paris 7, IFR58, 15-21 rue de l'Ecole de Médecine, 75270 Paris, France.
Lezot
F
F
Kato
S
S
Bailleul-Forestier
I
I
Berdal
A
A
D000539:Alveolar Process / Q000002:abnormalities*; D000818:Animals; D002118:Calcium / Q000097:blood*; D051379:Mice; D008822:Mice, Transgenic; D014807:Vitamin D / Q000097:blood*
D014807:Vitamin D; D002118:Calcium