Cortisol response to buspirone in extended abstinent alcoholics.
We evaluated cortisol response to buspirone in extended abstinent alcoholic patients to determine 5-HT1A receptor sensitivity in alcoholism. Alcoholic patients were inpatients with an extended abstinent period of at least 3 months. Alcoholics had a significantly lower cortisol level than did the normal controls from 60 min through to 150 min after administration of 30 mg buspirone. Our results show that cortisol response to buspirone was significantly decreased in alcoholic patients compared to normal controls, reflecting decreased 5-HT1A receptor sensitivity.
Kim
Young-Hoon
YH
Department of Psychiatry, Busan Paik Hospital 633-165 Gaegum-Dong, Busanjin-Gu, 614-735, Republic of Korea.
Shim
Joo-Cheol
JC
Kelly
Deanna L
DL
Lee
Jeong-Goo
JG
Seo
Young-Soo
YS
Conley
Robert R
RR
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D000704:Analysis of Variance; D002065:Buspirone / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013695:Temperance
D002065:Buspirone; D006854:Hydrocortisone