The genetic basis of neuroticism.
Gray has drawn upon genetic evidence to argue for the existence of rodent emotionality, a model of human neuroticism. With the advent of molecular mapping techniques it has become possible to test this hypothesis. Here I review the progress that has been made, largely in animal genetic studies, demonstrating that a common set of genes act pleiotropically on measures of emotionality. More recently, evidence has emerged supporting the view that the same genes influence variation in both rodent and human phenotypes.
Flint
Jonathan
J
Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK. jf@well.ox.ac.uk
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D004644:Emotions / Q000502:physiology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009497:Neurotic Disorders / Q000235:genetics* / Q000503:physiopathology; D013045:Species Specificity