[Study of glycolaldehyde on DNA damage in mouse spleen lymphocytes].
OBJECTIVE
Study the effect of glycolaldehyde on DNA of mouse spleen lymphocytes.


METHODS
The DNA damage induced by different concentrations of glycolaldehyde was detected using single cell gel electrophoresis assay (SCGE).


RESULTS
Glycolaldehyde at 0.01 mmol/L could induce lymphocyte DNA strand breakage and DNA damage rate was 8% and, the average migration distance of DNA was (14.32 +/- 2.84) micron. DNA damage rate and the average migration distance of DNA were increased in a concentration-dependent manner.


CONCLUSIONS
glycolaldehyde could induce DNA damage in different concentration in this experiment.
Liang
Yajing
Y
Institute of Frontier Medical Science, Jilin University, Changchun 130021, China.
Li
Cai
C
Hou
Fangyu
F
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000633:toxicity*; D000818:Animals; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D051379:Mice; D013154:Spleen / Q000166:cytology*
D000079:Acetaldehyde; C010972:glycolaldehyde