[A retrospective analysis on multiple cord blood transplantation in 13 cases].
In order to study the feasibility of multi-umbilical cord blood transplantation (multi-UCBT) in adult, 13 cases of unrelated allogeneic multi-UCBT performed from June 1998 to July 2003 were analyzed retrospectively. All cord blood units were obtained from full term normal vaginal and cesarean deliveries in Guangzhou Maternity and Neonatal Hospital. The fractionation, cryopreservation and thawing of cord blood were done according to the regulation of New York Umbilical Cord Blood Bank and pertinent literatures. Donors of HLA 1/6-2/6 mismatch were accepted at registry search. The results showed that from June 1998 to July 2003, 28 umbilical cord blood units were selected by 7 transplantation centers for 13 cases. The median age of recipients was 22 (8 - 41) years, and the median weight was 50 (21 - 75) kg, the median infused dose of total nuclear cells was 2.91 x 10(7)/kg. Six out of thirteen cases were engrafted after cord blood infusion with absolute neutrophil count of > 5.0 x 10(8)/L at 19 days post-infusion. Only one case suffered from graft versus host disease, the total survival of multi-UCBT was 46.2% (6/13). It is concluded that good prospects in the field of multi-umbilical cord blood transplantation is likely to be realized.
Liao
Can
C
Guangzhou Maternity and Neonatal Hospital, Guangzhou Cord Blood Bank, Guangzhou 510180, China. canliao@hotmail.com
Yang
Xi
X
Xu
Zun-Peng
ZP
Chen
Jing-Song
JS
Huang
Yi-Ning
YN
Liu
Bin
B
Wu
Shao-Qing
SQ
Gu
Shao-Ling
SL
Li
Yan
Y
Tang
Xue-Wei
XW
Wu
Jie-Ying
JY
D000293:Adolescent; D000328:Adult; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000401:mortality; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D006801:Humans; D008297:Male; D012189:Retrospective Studies