title: Effects of chlordane and lindane on testosterone and vitellogenin levels in green neon shrimp (Neocaridina denticulata).
abstract: The purpose of this study was to investigate the acute toxicity of chlordane and lindane as well as their endocrine disruption effect on green neon shrimp (Neocaridina denticulata), a common habitant in freshwater system of eastern Asia and Hawaii. First, the organisms were exposed to chlordane and lindane to estimate the 96-h LC(50)(96-h median lethal concentration). Then, levels of testosterone and vitellogenin in hemolymph of N. denticulata after exposure to sublethal concentrations of chlordane (1 ng/L and 10 ng/L) and lindane (0.1 microg/L and 1 microg/L) were also examined. The 96-h LC(50) values obtained from the results of acute exposure were 127.03 (130.11-122.35) ng/L and 9.36 (8.00-10.96) microg/L for chlordane and lindane, respectively. Furthermore, reductions of testosterone concentration were observed in both chlordane- and lindane-treated shrimps, whereas induction of vitellogenin-like protein was only apparent in chlordane-treated shrimps. Thus, it is concluded that chlordane and lindane may probably show some disruption endocrine functions on N. denticulata.
authors.affiliation: Institute of Zoology, National Taiwan University, No. 1 Sec. 4 Roosevelt Road, Taipei 106, Taiwan, Republic of China.
authors.forename: Da-Ji
authors.initials: DJ
authors.lastname: Huang
authors.forename: Hon-Cheng
authors.initials: HC
authors.lastname: Chen
mesh_terms: D000818:Animals; D002706:Chlordan / Q000008:administration & dosage / Q000633:toxicity*; D033364:Decapoda / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D013739:Testosterone / Q000378:metabolism*; D013997:Time Factors; D014819:Vitellogenins / Q000378:metabolism*
chemical_list: D007306:Insecticides; D014819:Vitellogenins; D002706:Chlordan; D013739:Testosterone; D004958:Estradiol; D001556:Hexachlorocyclohexane