title: Clinical trial design issues in the era of targeted therapies.
abstract: Although our lack of effective therapies mandates the development of new, molecularly targeted therapies, a number of issues in the design of clinical trials and their end points remain to be considered.
authors.affiliation: University of Wisconsin. Madison, Wisconsin, USA. jhschill@wisc.edu
authors.forename: Joan H
authors.initials: JH
authors.lastname: Schiller
mesh_terms: D002986:Clinical Trials as Topic; D015195:Drug Design; D023381:Endpoint Determination; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D018579:Patient Selection; D011956:Receptors, Cell Surface / Q000502:physiology; D012107:Research Design
chemical_list: D011956:Receptors, Cell Surface