title: Acute large bowel pseudo-obstruction due to multiple myeloma.
abstract: Involvement of the gastrointestinal (GI) tract by multiple myeloma (MM) is extremely rare. The small intestine and stomach are the most frequent sites of spread. We report 1 case of a 61-year-old woman who presented with clinical and radiographic features of an acute large bowel pseudo-obstruction. An abdominal computerized tomography (CT) showed a large tumor of the rectum. On morphological and immunohistochemical examination the tumor fulfilled the criteria of MM. The patient received combined chemotherapy and radiotherapy which led to the disappearance of the tumor. A review of the literature revealed that this is the first reported case of MM presented as acute large bowel pseudo-obstruction due to a rectal myeloma tumor.
authors.affiliation: Department of Pathology, Hippokration General Hospital, Thessaloniki, Greece. ivenizel@otenet.gr
authors.forename: Ioannis
authors.initials: I
authors.lastname: Venizelos
authors.forename: Stamatia
authors.initials: S
authors.lastname: Theodoridou
authors.forename: Sofia
authors.initials: S
authors.lastname: Vakalopoulou
authors.forename: Vassilios
authors.initials: V
authors.lastname: Perifanis
authors.forename: Timoleon
authors.initials: T
authors.lastname: Vyzantiadis
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Garipidou
mesh_terms: D003112:Colonic Pseudo-Obstruction / Q000209:etiology* / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D003113:Colonoscopy; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000378:metabolism; D053667:Syndecans
chemical_list: D008562:Membrane Glycoproteins; D011509:Proteoglycans; D053667:Syndecans