[Characteristics of immune system in patients with metabolic syndrome].
OBJECTIVE
To characterize features of immune status in patients with metabolic syndrome (MS).


METHODS
41 MS patients entered the study (mean age 55.9 +/- 9.7 years). Blood free triiodthyronine (T3f), thyroxine (T4f), TTH, antibodies to thyroglobulin (abTG), thyroid peroxidase (AbTP) were studied with enzyme immunoassay; levels of CD3+, CD4+, CD8+, CD16+, CD72+ were studied with monoclonal antibodies; IgG, IgA, IgM were measured by radial immunodiffusion in gel by Manchini. The size and the structure of the thyroid were investigated with ultrasound.


RESULTS
Thyroid pathology was in 48.8% patients with MS, chronic infectious diseases (CID)--in 51.2%. MS patients free of thyroid pathology and CID had elevated blood levels of IgG, IgA, dysimmunoglobulinemia and low relative number of CD3+ lymphocytes, close correlations of T3free with the levels of CD3+, CD4+, CD8+, T4free with CD72+ (r = -0.97 to +0.92), T4free with IgA, IgG (r = -0.96, r = -0.90), TTH and IgA (r = -0.89), weak negative correlations of uric acid with the levels of CD3+, CD4+, CD72+ and positive with CD8+, CD16+, immunoglobulins. Combination of MS with thyroid pathology and/or CID was characterized with aggravated defects in T- and B-cell immunity, fall in IgG, IgA and changed direction of correlations of thyroid and immune statuses.


CONCLUSIONS
Immune status in MS patients was characterized by stimulation of humoral immunity, dysimmunoglobulinemia, T-cell immunity deficiency. This may be related to chronic hyperinsulinemia, dyslipidemia, antigenic stimulation with modified lipoproteins. Thyroid hormones levels positively correlate with concentrations of immunocytes and negatively--with immunoglobulins.
Zabelina
V D
VD
Zemskov
V M
VM
Mkrtumian
A M
AM
Balabolkin
M I
MI
Antonova
O A
OA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000917:Antibody Formation / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D015992:Body Mass Index; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D007239:Infections / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology; D013959:Thyroid Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology* / Q000378:metabolism; D013963:Thyroid Hormones / Q000032:analysis; D014463:Ultrasonography
D015703:Antigens, CD; D007136:Immunoglobulins; D013963:Thyroid Hormones