title: Recent developments in marine indole alkaloid synthesis.
abstract: The manzamine alkaloids such as manzamine A, B, and C belongs to a unique family of cyctotoxic beta-carbline linked azacycles, which have been isolated from several marine sponges. Manzamine A has recently been shown to exhibit in vivo antimalarial activity against parasite Plasmodium berghei. Further progress was added recently by the isolation of the new and closely related members such as nakadomarin A, as well as an ingenious proposal for their biosynthetic pathway. Martefragin A, isolated from the Japan sea alga Martensia fragilis Harvey, has been shown to have a potent inhibitory activity against lipid peroxidation. Our recen, efforts to develop total synthesis entries to manzamine A, manzamine B, manzamine C, nakadomarin A, and martefragin A are presented.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba-shi, 263-8522, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Nakagawa
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nagata
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.forename: Hideharu
authors.initials: H
authors.lastname: Uchida
authors.forename: Takeshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hatakeyama
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Akiba
authors.forename: Mihoko
authors.initials: M
authors.lastname: Fuwa
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Arisawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nishida
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002227:Carbazoles; D056890:Eukaryota / Q000737:chemistry; D066298:In Vitro Techniques; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008386:Marine Biology; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010962:Plasmodium berghei / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D002227:Carbazoles; D026121:Indole Alkaloids; D007211:Indoles; C115837:Martefragin A; D011758:Pyrroles; C078290:manzamine A