[Endometriosis and discouragement of immunology cytotoxic characteristics].
OBJECTIVE
To determine the immunology kind of response Th1 (cytotoxic) or Th2 (humoral) prevailing at peripheral and peritoneal environment at endometriosis women (ENW).


METHODS
Observational, transverse, analytical, retrospective, cases and controls.


METHODS
Cooperative and cytotoxic lymphocytes obtained from peritoneal fluid (PF) and peripheral blood (PB) were used to determine IFN-gamma and IL-2 intracellular synthesis at ENW. IFN-gamma, IL-2, IL-4 and IL-10 concentration were determined at PF, PB at ENW and fertile women (FERW). Results were analyzed by ANOVA, t student and Mann-Whitney tests, accepting p < 0.05, as a statistic difference.


RESULTS
Peritoneal environment of ENW shows a smaller intracellular synthesis of IFN-gamma and IL-2 at cooperative and cytotoxic T lymphocytes, as in the PF at ENW. The decrease is associated to a smaller percentage of activated, cooperative T lymphocytes and NK cells (p < 0.05, at all the variable), versus FERW. This phenomenon is observed more stressed at the III and IV pathology degree.


CONCLUSIONS
ENW show a peritoneal environment with a smaller immunology cytotoxic capacity, versus FERW. The discouragement of the immunology cytotoxic capacity increases associated to the pathology intensity.
Hernández Guerrero
César Angel
CA
Departamento de Ultramicroscopía, Instituto Nacional de Perinatología.
Tlapanco Barba
Rubén
R
Ramos Pérez
Carlos
C
Velázquez Ramírez
Norma
N
Castro Eguiluz
Denisse
D
Cérbulo Vázquez
Arturo
A
D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003602:Cytotoxicity, Immunologic; D004715:Endometriosis / Q000276:immunology*; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology*; D006801:Humans; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology