title: Value of cervical phosphorylated insulinlike growth factor binding protein-1 in the prediction of preterm labor.
abstract: OBJECTIVE
  To determine the value of cervical phosphorylated insulinlike growth factor binding protein-1 (IGFBP-1) in the prediction of preterm labor.
  
  
  METHODS
  In this prospective study, 77 pregnant women, gestational age 24-36 weeks, were enrolled in the study. Twenty women with completely healthy pregnancies formed the control group. Fifty-seven women with signs and symptoms of preterm labor formed the study group. Phosphorylated IGFBP-1 in cervical secretions was assessed in all patients by using a qualitative, immunochromatographic, 1-step dipstick test. Cervical length was measured by transvaginal sonography.
  
  
  RESULTS
  The IGFBP-1 test was negative in all patients in the control group (n = 20), and all of them delivered after 37 weeks, while the test was positive in 15 of 45 (33.3%) patients in the study group. The correlation between cervical length and gestational age at the time of delivery in patients with a positive phosphorylated IGFBP-1 test (n = 15) was significant (r = .553, P = .03). The sensitivity, specificity, positive predictive value and negative predictive value for the phosphorylated IGFBP-1 test were 78%, 87%, 73% and 90%, respectively.
  
  
  CONCLUSIONS
  Use of a 1-step dipstick test for detecting phosphorylated IGFBP-1 in cervical secretions is of value in the prediction of preterm labor. The high negative predictive value of the test may be useful in avoiding unnecessary medical interventions.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University, Faculty of Medicine, Izmir, Turkey.
authors.forename: Fuat
authors.initials: F
authors.lastname: Akercan
authors.forename: Mert
authors.initials: M
authors.lastname: Kazandi
authors.forename: Fatih
authors.initials: F
authors.lastname: Sendag
authors.forename: Teksin
authors.initials: T
authors.lastname: Cirpan
authors.forename: Leila
authors.initials: L
authors.lastname: Mgoyi
authors.forename: Mustafa Cosan
authors.initials: MC
authors.lastname: Terek
authors.forename: Sermet
authors.initials: S
authors.lastname: Sagol
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000737:chemistry*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000032:analysis*; D007752:Obstetric Labor, Premature; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1