Pharmacological characterization of P2-receptors in human fallopian tubes.
In women with various gynecological disorders, ATP, ADP, and 2-methylthio-ATP dose-dependently potentiated spontaneous contractility of isolated fallopian tubes, while alpha,beta-methylene-ATP and uridine triphosphate were little efficient. Pyridoxal phosphate-6-azophenyl-2',4'-disulphonic acid, a P2-receptor antagonist, inhibited responses to 2-methylthio-ATP, produced no effect on responses to ATP, and potentiated ADP-induced responses in fallopian tubes. During inflammation, sensitivity of fallopian tubes to P2 agonists and antagonists decreased. The data attest to the presence of functionally active P2 receptors in human fallopian tubes probably involved in the regulation of their mechanical activity.
Ziganshin
A U
AU
Department of Pharmacology, Kazan State Medical University. airatz@auz.kcn.ru
Vafina
Z R
ZR
Fatkullin
I F
IF
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000328:Adult; D005187:Fallopian Tubes / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2 / Q000502:physiology; D012488:Salpingitis / Q000503:physiopathology; D013873:Thionucleotides / Q000494:pharmacology
D058910:Purinergic P2 Receptor Agonists; D058919:Purinergic P2 Receptor Antagonists; D018048:Receptors, Purinergic P2; D013873:Thionucleotides; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; C008501:2-methylthio-ATP