The effects of dietary myoinositol on lung tumor development in tobacco smoke-exposed mice.
The purpose of these experiments was to investigate whether a diet containing myoinositol could prevent the development of tobacco smoke-induced lung tumors in strain A/J mice. In a positive control experiment, 1% and 3% of myoinositol in AIN-93 diet reduced the development of lung tumors induced by NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] by 69% and 75%. In animals exposed for 5 mo, 6 h/day, 5 days/wk, to a mixture of tobacco sidestream and mainstream smoke, and then fed myoinositol-containing diets once smoke exposure had ceased, no chemopreventive effect was observed. When animals were fed myoinositol during both tobacco smoke exposure and the recovery period, a slight but statistically not significant reduction in tumor multiplicities was found. It was concluded that myoinositol has less chemopreventive activity against the full complex mixture of tobacco smoke than it has against selected constituents such as NNK or benzo[a]pyrene.
Witschi
Hanspeter
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Center for Health and the Environment, University of California, Davis, California, USA. hrwitschi@ucdavis.edu
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity; D004032:Diet; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007294:Inositol / Q000008:administration & dosage*; D008175:Lung Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009602:Nitrosamines / Q000008:administration & dosage / Q000633:toxicity; D012906:Smoke / Q000009:adverse effects* / Q000032:analysis
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D009602:Nitrosamines; D012906:Smoke; D007294:Inositol; C016583:4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone