Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties.
The preparation and cytotoxic properties of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione derivatives carrying N-aminoalkyl substituents are described. The N-aminobutylnaphthoindolediones obtained were studied in National Cancer Institute Screening Program and demonstrated high antiproliferative activity against 60 human cancer cell lines. All N-(4-aminobutyl) derivatives have higher potency than adriamycin or mitoxantrone against adriamycin selected multidrug resistant breast cancer cell line NCI/ADR.
Shchekotikhin
Andrey E
AE
Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirogovskaya, 11, Moscow 119021, Russia. mnp@space.ru
Buyanov
Vladimir N
VN
Preobrazhenskaya
Maria N
MN
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009284:Naphthols / Q000138:chemical synthesis* / Q000494:pharmacology*; D013057:Spectrum Analysis
D000970:Antineoplastic Agents; D009284:Naphthols