title: [A retrospective analysis on multiple cord blood transplantation in 13 cases].
abstract: In order to study the feasibility of multi-umbilical cord blood transplantation (multi-UCBT) in adult, 13 cases of unrelated allogeneic multi-UCBT performed from June 1998 to July 2003 were analyzed retrospectively. All cord blood units were obtained from full term normal vaginal and cesarean deliveries in Guangzhou Maternity and Neonatal Hospital. The fractionation, cryopreservation and thawing of cord blood were done according to the regulation of New York Umbilical Cord Blood Bank and pertinent literatures. Donors of HLA 1/6-2/6 mismatch were accepted at registry search. The results showed that from June 1998 to July 2003, 28 umbilical cord blood units were selected by 7 transplantation centers for 13 cases. The median age of recipients was 22 (8 - 41) years, and the median weight was 50 (21 - 75) kg, the median infused dose of total nuclear cells was 2.91 x 10(7)/kg. Six out of thirteen cases were engrafted after cord blood infusion with absolute neutrophil count of > 5.0 x 10(8)/L at 19 days post-infusion. Only one case suffered from graft versus host disease, the total survival of multi-UCBT was 46.2% (6/13). It is concluded that good prospects in the field of multi-umbilical cord blood transplantation is likely to be realized.
authors.affiliation: Guangzhou Maternity and Neonatal Hospital, Guangzhou Cord Blood Bank, Guangzhou 510180, China. canliao@hotmail.com
authors.forename: Can
authors.initials: C
authors.lastname: Liao
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Zun-Peng
authors.initials: ZP
authors.lastname: Xu
authors.forename: Jing-Song
authors.initials: JS
authors.lastname: Chen
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Shao-Qing
authors.initials: SQ
authors.lastname: Wu
authors.forename: Shao-Ling
authors.initials: SL
authors.lastname: Gu
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Xue-Wei
authors.initials: XW
authors.lastname: Tang
authors.forename: Jie-Ying
authors.initials: JY
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D036101:Cord Blood Stem Cell Transplantation / Q000401:mortality; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D006801:Humans; D008297:Male; D012189:Retrospective Studies