Extragonadal luteinizing hormone receptors in the reproductive tract of domestic animals.
Binding sites for LH/hCG and/or its mRNA are found in the uterus of several species, including human, primate, pig, cow, and turkey. Activation of LH receptors around Day 15 of the estrous cycle is associated with increased prostaglandin F(2alpha) production in the bovine, porcine, and ovine uterus. Activation of uterine LH receptors is also associated with increased levels of prostaglandins in human and primate. The presence of gonadotropin receptors with a dynamic pattern in the oviduct, endometrium, myometrium, and cervix of different species provides evidence that gonadotropins play a substantial role in molecular autocrine-paracrine regulation of the estrous cycle and implantation.
Fields
Michael J
MJ
Department of Animal Sciences, University of Florida, Gainesville, Florida 32611, USA. fields@animal.ufl.edu
Shemesh
Mordechai
M
D000818:Animals; D000829:Animals, Domestic / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism; D005187:Fallopian Tubes / Q000378:metabolism; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D009215:Myometrium / Q000378:metabolism; D011974:Receptors, LH / Q000235:genetics / Q000378:metabolism*
D011974:Receptors, LH