title: Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes: family-based association study.
abstract: Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5-HT1Dalpha and 5-HT1Dbeta autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT). Concerning 5-HT1Dbeta autoreceptor gene, also negative results was obtained in the analysis of the haplotypes with transmit. Thus, our data provide no support for the hypothesis that polymorphisms at 5-HT1Dalpha (TaqI) and 5-HT1Dbeta (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population.
authors.affiliation: Center for Neuroscience of Coimbra, Department of Neurochemistry, Faculty of Medicine, University of Coimbra, 3004-517 Coimbra, Portugal. aldachico@yahoo.com
authors.forename: Alda M
authors.initials: AM
authors.lastname: Ambrósio
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: Fabio
authors.initials: F
authors.lastname: Macciardi
authors.forename: Isabel
authors.initials: I
authors.lastname: Coelho
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Soares
authors.forename: Catarina R
authors.initials: CR
authors.lastname: Oliveira
authors.forename: Carlos N
authors.initials: CN
authors.lastname: Pato
mesh_terms: D017660:Autoreceptors / Q000235:genetics; D005192:Family Health; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D011174:Portugal / Q000453:epidemiology; D044302:Receptor, Serotonin, 5-HT1B / Q000235:genetics*; D044346:Receptor, Serotonin, 5-HT1D / Q000235:genetics*; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*
chemical_list: D017660:Autoreceptors; D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D