Perturbation of natural killer cell function and receptors during HIV infection.
Natural killer (NK) cells play an important role in innate host defenses against a variety of pathogens. A recent report described striking perturbations in the expression of NK cell inhibitory and activating receptors in viremic human immunodeficiency virus (HIV)-infected patients, leading to functional abnormalities in these cells. This finding provides a mechanistic insight into NK cell dysfunction and its possible contribution to the impairment of innate host defenses in HIV-infected individuals.
Eger
Karla A
KA
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Unutmaz
Derya
D
D016207:Cytokines / Q000378:metabolism; D005786:Gene Expression Regulation; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D011971:Receptors, Immunologic / Q000502:physiology*; D014766:Viremia
D016207:Cytokines; D011971:Receptors, Immunologic