title: Bromophenol derivatives from the red alga Rhodomela confervoides.
abstract: Eight new bromophenol derivatives, 2,3-dibromo-4,5-dihydroxybenzyl methyl sulfoxide (1), 4-(2,3-dibromo-4,5-dihydroxyphenyl)-3-butene-2-one (2), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (3), 2-(3-bromo-5-hydroxy-4-methoxyphenyl)-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid methyl ester (4), 2-phenyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propionic acid (5), 4'-methoxy-2'',3',3''-tribromo-4'',5',5''-trihydroxydiphenylacetic acid (6), and 3-bromo-5-hydroxy-4-methoxyphenylacetic acid (7) and its methyl ester (8), together with a known bromophenol, 3-bromo-5-hydroxy-4-methoxybenzoic acid (9), were isolated from the red alga Rhodomela confervoides. Their structures were elucidated by spectroscopic methods including IR, EIMS, FABMS, ESIMS, HRFABMS, HRESIMS, 1D and 2D NMR, and single-crystal X-ray structure analysis. Compounds 1-4, 8, and 9 were found inactive against several human cancer cell lines and microorganisms.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100050.
authors.forename: Jielu
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiao
authors.initials: X
authors.lastname: Fan
authors.forename: Sujuan
authors.initials: S
authors.lastname: Wang
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Suqin
authors.initials: S
authors.lastname: Shang
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Nianjun
authors.initials: N
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Lü
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D002681:China; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000461:Rhodophyta / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D006842:Hydrocarbons, Brominated; D010636:Phenols