Biotransformation of imperatorin by Aspergillus flavus.
Imperatorin (1) was metabolized by Aspergillus flavus, in growth media, to give five metabolites. On the basis of their physical data, the structures of the five metabolites were elucidated as xanthotoxol (2), E-trichoclin (3), Z-trichoclin (4), E-imperatorin acid (5), and Z-imperatorin acid (6); among these, 4, 5, and 6 were characterized as new coumarins. The five metabolites 2-6 were tested for anti-hepatitis B virus activity in vitro and found to be less active than the parent compound 1.
Teng
Wen-Yuh
WY
Department of Agricultural Chemistry, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 106, Taiwan, Republic of China.
Huang
Yu-Ling
YL
Huang
Ray-Ling
RL
Chung
Ren-Shih
RS
Chen
Chien-Chih
CC
D000998:Antiviral Agents / Q000378:metabolism* / Q000494:pharmacology; D001231:Aspergillus flavus / Q000378:metabolism*; D001711:Biotransformation; D003374:Coumarins / Q000737:chemistry; D011564:Furocoumarins / Q000378:metabolism* / Q000494:pharmacology; D006515:Hepatitis B virus / Q000378:metabolism; D015394:Molecular Structure; D013237:Stereoisomerism; D013624:Taiwan
D000998:Antiviral Agents; D003374:Coumarins; D011564:Furocoumarins; C031534:imperatorin