title: Antibacterial, antifungal, antiplasmodial, and cytotoxic activities of Albertisia villosa.
abstract: Albertisia villosa (Menispermaceae) is a subtropical medicinal plant that is widely used in traditional African medicines against various diseases. Three known bisbenzylisoquinoline alkaloids; cycleanine, cocsoline, and N-desmethylcycleanine have been identified. Cycleanine, the most abundant (85%) of all identified bisbenzylisoquinoline alkaloids, accounts for all of the activity of the crude drug. The biological screening of cycleanine and the root bark alkaloidal extract revealed potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. These results may partly explain and support the use of Albertisia villosa root barks for the treatment of malaria and other infectious diseases in traditional Congolese medicine.
authors.affiliation: Institut Supérieur des Techniques Médicales, B.P. 774 Kinshasa XI, R.D. Congo.
authors.forename: M-L
authors.initials: ML
authors.lastname: Lohombo-Ekomba
authors.forename: P N
authors.initials: PN
authors.lastname: Okusa
authors.forename: O
authors.initials: O
authors.lastname: Penge
authors.forename: C
authors.initials: C
authors.lastname: Kabongo
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: O E
authors.initials: OE
authors.lastname: Kasende
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016778:Malaria, Falciparum / Q000188:drug therapy; D029583:Menispermaceae; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000962:Antimalarials; D010936:Plant Extracts