Regional distribution of cyclooxygenase-3 mRNA in the rat central nervous system.
We determined COX-3 mRNA expression in regions of the rat central nervous system (CNS). On a regional basis, levels were the highest in choroid plexus and spinal chord followed by pituitary gland, hypothalamus, hippocampus, medulla, cerebellum, and cortex. COX-3 mRNA levels were higher in major brain arteries, and dramatically higher in brain microvessels. Our results suggest that the expression pattern of COX-3 mRNA in the rat CNS primarily relates to the vascular density of a given region.
Kis
Bela
B
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157, USA. bkis@wfubmc.edu
Snipes
Andy
A
Bari
Ferenc
F
Busija
David W
DW
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D051545:Cyclooxygenase 1; D008297:Male; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism*
D008565:Membrane Proteins; D012333:RNA, Messenger; D051545:Cyclooxygenase 1; D011451:Prostaglandin-Endoperoxide Synthases; C496513:Ptgs1 protein, rat; C466421:cyclooxygenase-3