Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.
A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.
Blizzard
Timothy A
TA
Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
DiNinno
Frank
F
Morgan
Jerry D
JD
Wu
Jane Y
JY
Chen
Helen Y
HY
Kim
Seongkon
S
Chan
Wanda
W
Birzin
Elizabeth T
ET
Yang
Yi Tien
YT
Pai
Lee-Yuh
LY
Zhang
Zhoupeng
Z
Hayes
Edward C
EC
DaSilva
Carolyn A
CA
Tang
Wei
W
Rohrer
Susan P
SP
Schaeffer
James M
JM
Hammond
Milton L
ML
D000818:Animals; D005260:Female; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D011960:Receptors, Estrogen / Q000378:metabolism*; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
D008024:Ligands; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators