A possible effect of amisulpride on a prolactinoma growth in a woman with borderline personality disorder.
The authors report the case of a woman with borderline personality disorder who developed a prolactinoma probably induced by amisulpride. This patient was treated with 300 mg of amisulpride per day for a delirium. Her brain MRI was normal. Four months later this patient developed a micro-adenoma (5mm) on the right side of the pituitary gland with amenorrhea and galactorrhea. Amisulpride treatment was withdrawn and replaced by a treatment of quetiapine 100 mg day(-1). The hyperprolactinemia symptoms disappeared. This report shows that the short-term use of amisulpride treatment was linked to an elevation in the PRL level with a possible induction of a pituitary adenoma.
Perroud
Nader
N
Département de Psychiatrie, Hôpitaux Universitaires de Genève, 36, Rue du XXXI Décembre, 1207 Geneva, Switzerland.
Huguelet
Philippe
P
D000328:Adult; D000077582:Amisulpride; D001883:Borderline Personality Disorder / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010911:Pituitary Neoplasms / Q000097:blood / Q000139:chemically induced*; D011388:Prolactin / Q000097:blood; D015175:Prolactinoma / Q000097:blood / Q000139:chemically induced*; D013469:Sulpiride / Q000009:adverse effects* / Q000031:analogs & derivatives*
D013469:Sulpiride; D000077582:Amisulpride; D011388:Prolactin