title: Reversible meiotic abnormalities in azoospermic men with bilateral varicocele after microsurgical correction.
abstract: Because of a possible relationship between microenvironmental disturbances and meiotic abnormalities and of a straight relationship between lower-quality semen in patient carrying a varicocele and first meiotic non-disjunction, bilateral bipolar testicular biopsies are realized according the thermic differential gradient described in varicocele. Systematic meiotic studies of multiple testicular biopsies from 65 azoospermic men with bilateral varicocele were done in a multi-centric study on microsurgical correction of bilateral varicocele with microthermic intra-operative evaluation using minimally invasive thermal microsensors (Betatherm 10K3MCD2). In the present study abnormal temperature raising, histomorphometric abnormalities (spermatocyte arrest) and meiotic abnormalities (class IIC) are strongly correlated. In the ten patients submitted to another testicular biopsy procedure six months after surgery for TESE, normal thermal differential is registered and no meiotic abnormalities recurrences are found.
authors.affiliation: Laboratoire d'Histologie Embryologie, Cytogénétique et Anatomie Pathologique, Hôpital Saint Vincent de Paul, 84, Boulevard Denfert Rochereau, 75014 Paris, France. mo.north@teso.net
authors.forename: M O
authors.initials: MO
authors.lastname: North
authors.forename: I
authors.initials: I
authors.lastname: Lellei
authors.forename: N
authors.initials: N
authors.lastname: Rives
authors.forename: E
authors.initials: E
authors.lastname: Erdei
authors.forename: A
authors.initials: A
authors.lastname: Dittmar
authors.forename: J P
authors.initials: JP
authors.lastname: Barbet
authors.forename: G
authors.initials: G
authors.lastname: Tritto
mesh_terms: D001706:Biopsy; D001831:Body Temperature; D002467:Cell Nucleus / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006801:Humans; D007248:Infertility, Male / Q000209:etiology; D008297:Male; D008540:Meiosis; D008839:Microelectrodes / Q000706:statistics & numerical data; D008866:Microsurgery; D009845:Oligospermia / Q000209:etiology / Q000473:pathology*; D049471:Pachytene Stage; D013737:Testis / Q000098:blood supply / Q000473:pathology; D013821:Thermometers / Q000706:statistics & numerical data; D014646:Varicocele / Q000150:complications / Q000601:surgery*