The role of adaptor proteins in lymphocyte activation.
Research within the last 10 years has provided compelling evidence that adaptor proteins regulate the major pathways of lymphocyte activation. Based upon their differential subcellular localization, transmembrane adaptors and cytosolic adaptors can be distinguished. Here we review some of the most recent findings about both types of adaptor proteins which have facilitated our understanding how immunoreceptors control lymphocyte activation and differentiation.
Togni
Mauro
M
Institute of Immunology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
Lindquist
Jon
J
Gerber
Annegret
A
Kölsch
Uwe
U
Hamm-Baarke
Andrea
A
Kliche
Stefanie
S
Schraven
Burkhart
B
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport / Q000276:immunology / Q000502:physiology*; D000818:Animals; D002352:Carrier Proteins / Q000276:immunology / Q000502:physiology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology*; D008565:Membrane Proteins / Q000276:immunology / Q000502:physiology; D010750:Phosphoproteins / Q000276:immunology / Q000502:physiology; D011506:Proteins / Q000276:immunology / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; C106957:FYB1 protein, human; C491468:Fyb protein, mouse; C419196:LAT2 protein, human; C488163:LAT2 protein, mouse; C469997:LAX1 protein, human; C480489:Lck-interacting protein, mouse; D008565:Membrane Proteins; D010750:Phosphoproteins; D011506:Proteins; C108336:SKAP1 protein, human