title: Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.
abstract: Laminin-8 (alpha 4 beta 1 gamma 1) is one of the major laminin isoforms expressed in vascular endothelial basement membranes. Here we show that deletion of laminin-8 in mice affects angiogenesis under pathological conditions. Murine tumor models used in laminin alpha 4-deficient mice results in hyperneovascularization and significant promotion of tumor growth and metastasis. The higher tumor growth rates in mutant mice correlate with decreased tumor cell apoptosis. Depletion of laminin alpha 4 chain may alter the structure of vascular basement membranes, leading to increased angiogenesis. Our data suggest that the laminin-8 plays a critical role in the regulation of pathological angiogenesis.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Hong Kong, People's Republic of China. zhongjun@hkucc.hku.hk
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Zhou
authors.forename: Masayuki
authors.initials: M
authors.lastname: Doi
authors.forename: Jianming
authors.initials: J
authors.lastname: Wang
authors.forename: Renhai
authors.initials: R
authors.lastname: Cao
authors.forename: Baohua
authors.initials: B
authors.lastname: Liu
authors.forename: Kui Ming
authors.initials: KM
authors.lastname: Chan
authors.forename: Jarkko
authors.initials: J
authors.lastname: Kortesmaa
authors.forename: Lydia
authors.initials: L
authors.lastname: Sorokin
authors.forename: Yihai
authors.initials: Y
authors.lastname: Cao
authors.forename: Karl
authors.initials: K
authors.lastname: Tryggvason
mesh_terms: D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D007797:Laminin / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics; D008546:Melanoma, Experimental / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D007797:Laminin; C110308:laminin 8; C097043:laminin alpha5