The stress reaction and its molecular events: splicing variants.
The growth of cells and tissues is regulated by stress. When body is injured, it manifests a large spectrum of metabolic, endocrine, and immune alterations, which is named stress reaction. Among them, the production of growth factors may play a critical role. For osteoblasts and myoblasts, IGF-I has been shown to be involved in the process of cells in response to overloads. There are two splicing forms, one is IGF-Ea, the other is the IGF-IEb in the rodents and corresponds to IGF-IEc in humans. The latter is markedly up-regulated in response to overloads. Therefore, it has been named mechanogrowth factor. The link between the mechanical stimulus and the gene expression represents a new and important area in cell science. Understanding the process of splicing in IGF-I helps one to investigate the mechanotransduction of cells in response to mechanical stimulation at molecular level.
Tang
Li-Ling
LL
Key Laboratory of Biomechanics and Tissue Engineering of Ministry of Education, Bio-engineering College, Chongqing University, Chongqing 400044, PR China. huayue@cta.cq.cn
Wang
Yuan-Liang
YL
Sun
Cai-Xin
CX
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology; D012326:RNA Splicing; D013312:Stress, Physiological / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*
D007334:Insulin-Like Growth Factor I