Strictinin as an efficient antioxidant in lipid peroxidation.
The antioxidant effect of strictinin (SOH), which was extracted from green tea leaves, against the peroxidation of linoleic acid in sodium dodecyl sulfate (SDS) and cetyl trimethylammonium (CTAB) micelles, against the peroxidation of low-density lipoprotein (LDL) and against oxidative hemolysis of human red blood cells (RBCs), has been studied. The peroxidation of linoleic acid and LDL, and oxidative hemolysis of RBCs were initiated thermally by a water-soluble azo initiator 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH), and the reaction kinetics in micelles and LDL were monitored by uptake of oxygen. The synergistic antioxidant effect of SOH with alpha-tocopherol (Vitamin E) was also studied by following the decay kinetics of alpha-tocopherol. Kinetic analysis of the antioxidation process demonstrates that SOH, used either alone or in combination with alpha-tocopherol, is an effective antioxidant against lipid peroxidation, but its effects significantly depend on the reaction medium.
Zhou
Bo
B
National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China. bozhou@lzu.edu.cn
Yang
Li
L
Liu
Zhong-Li
ZL
D000975:Antioxidants / Q000494:pharmacology*; D002593:Cetrimonium Compounds / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D007700:Kinetics; D019787:Linoleic Acid / Q000737:chemistry; D015227:Lipid Peroxidation / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects* / Q000378:metabolism; D008823:Micelles; D010101:Oxygen Consumption; D010636:Phenols / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013662:Tea / Q000737:chemistry*; D014867:Water; D024502:alpha-Tocopherol / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D002593:Cetrimonium Compounds; D008077:Lipoproteins, LDL; D008823:Micelles; D010636:Phenols; D000644:Quaternary Ammonium Compounds; D013662:Tea; C496786:strictinin; D014867:Water; D012967:Sodium Dodecyl Sulfate; D019787:Linoleic Acid; D024502:alpha-Tocopherol