title: Notch signaling in Drosophila long-term memory formation.
abstract: Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, neither learning nor early memory were affected. Furthermore, induced overexpression of a wild-type (normal) N transgene specifically enhanced LTM formation. These experiments demonstrate that N signaling contributes to LTM formation in the Drosophila adult brain.
authors.affiliation: Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China.
authors.forename: Xuecai
authors.initials: X
authors.lastname: Ge
authors.forename: Frances
authors.initials: F
authors.lastname: Hannan
authors.forename: Zuolei
authors.initials: Z
authors.lastname: Xie
authors.forename: Chunhua
authors.initials: C
authors.lastname: Feng
authors.forename: Tim
authors.initials: T
authors.lastname: Tully
authors.forename: Haimeng
authors.initials: H
authors.lastname: Zhou
authors.forename: Zuoping
authors.initials: Z
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhong
mesh_terms: D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D004330:Drosophila; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000502:physiology*; D008568:Memory; D051880:Receptors, Notch; D015398:Signal Transduction
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch