A short synthesis of (+/-)-cytisine.
The synthesis of racemic cytisine has been completed using (i)N-selective alkylation of 6-bromopyridone with bromide and (ii) Pd(0) mediated intramolecular alpha-arylation of lactam as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.
Botuha
Candice
C
School of Chemistry, University of Bristol, Bristol, UKBS8 1TS.
Galley
Carl M S
CM
Gallagher
Timothy
T
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001392:Azocines / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D009538:Nicotine / Q000819:agonists; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry; D013034:Sparteine / Q000737:chemistry; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D001392:Azocines; D009538:Nicotine; D011807:Quinolizines; D013034:Sparteine; C004712:cytisine; D000093843:Quinolizidine Alkaloids