title: The Environmental Genome Project: phase I and beyond.
abstract: Human illness is caused by many interrelated factors including aging, inherited genetic predispositions, and a variety of environmental exposures. There is increasing awareness of the role of genetics as a factor that can dramatically alter susceptibility to all disease, especially environmentally induced chronic disease, such as cancer, asthma, diabetes, cardiovascular disease, and neurodegenerative disorders. In some cases, a genetic factor influences disease susceptibility in a small fraction of the population because it occurs at a low frequency or involves a relatively low-incidence disease; however, in other cases, a genetic factor increases susceptibility in a large number of individuals and involves a disease that occurs at high incidence, creating a large public health burden.
authors.affiliation: National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive Research Triangle Park, NC 27709-2233.
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Wilson
authors.forename: Kenneth
authors.initials: K
authors.lastname: Olden
mesh_terms: D043303:Aryldialkylphosphatase / Q000235:genetics; D001675:Bioethics; D030541:Databases, Genetic; D004777:Environment; D004781:Environmental Exposure; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D007938:Leukemia / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D054585:National Institute of Environmental Health Sciences (U.S.); D020641:Polymorphism, Single Nucleotide; D014481:United States
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2); D043303:Aryldialkylphosphatase; C468406:PON1 protein, human