title: The demonstration of an enhanced microelectrochemical transistor for measurements in neutral solution at low analyte concentration.
abstract: We report a new, sensitive detection method for the measurement of analytes based on the combination of conducting polymer technology and redox enzyme electrochemistry. This method provides a simple measurement method potentially enabling point of care testing on disposable electrodes in under 60 s. The measurement does not require a reference or counter electrode and the analytical signal is recorded by an ammeter measuring milliampere currents through a polymer transistor. Even at very low analyte concentration, the signal is not subject to significant noise.
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Astier
authors.forename: P N
authors.initials: PN
authors.lastname: Bartlett
mesh_terms: D000627:Aminophenols / Q000737:chemistry; D000814:Aniline Compounds / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D002138:Calibration; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008839:Microelectrodes; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry; D012680:Sensitivity and Specificity; D013997:Time Factors; D014173:Transistors, Electronic
chemical_list: D000627:Aminophenols; D000814:Aniline Compounds; D004798:Enzymes; D011108:Polymers; C416807:polyaniline; C026729:4-aminophenol