A convenient and biogenetic type synthesis of few naturally occurring chromeno dihydrochalcones and their in vitro antileishmanial activity.
2',2'-Dimethyl chromeno dihydrochalcones are very rare in nature as plant secondary metabolites. Recently we have reported three such compounds from the plant Crotalaria ramosissima. Chromeno dihydrochalcones contain a 2',2'-dimethyl benzopyran system, which are frequently encountered in many natural products and exhibit a variety of biological activities. We here report the strategy to conveniently synthesize naturally occurring chromeno dihydrochalcones by biogenetic type pyridine or Amberlyst-15 catalyzed chromenylation of dihydrochalcones and in vitro antileishmanial activity of chromeno dihydrochalcones and their intermediates.
Narender
Tadigoppula
T
Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226 001, India. tnarender@rediffmail.com
Shweta
Gupta
Suman
S
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D047188:Chalcones; D007887:Fabaceae; D007891:Leishmania / Q000187:drug effects* / Q000502:physiology; D009068:Movement / Q000187:drug effects
D000981:Antiprotozoal Agents; D001578:Benzopyrans; D047188:Chalcones; D002599:Chalcone; C015812:dihydrochalcone