title: Enhanced bone apposition to a chemically modified SLA titanium surface.
abstract: Increased surface roughness of dental implants has demonstrated greater bone apposition; however, the effect of modifying surface chemistry remains unknown. In the present study, we evaluated bone apposition to a modified sandblasted/acid-etched (modSLA) titanium surface, as compared with a standard SLA surface, during early stages of bone regeneration. Experimental implants were placed in miniature pigs, creating 2 circular bone defects. Test and control implants had the same topography, but differed in surface chemistry. We created the test surface by submerging the implant in an isotonic NaCl solution following acid-etching to avoid contamination with molecules from the atmosphere. Test implants demonstrated a significantly greater mean percentage of bone-implant contact as compared with controls at 2 (49.30 vs. 29.42%; p = 0.017) and 4 wks (81.91 vs. 66.57%; p = 0.011) of healing. At 8 wks, similar results were observed. It is concluded that the modSLA surface promoted enhanced bone apposition during early stages of bone regeneration.
authors.affiliation: Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Berne, Freiburgstrasse 7, PO Box 64, 3010 Berne, Switzerland. daniel.buser@zmk.unibe.ch
authors.forename: D
authors.initials: D
authors.lastname: Buser
authors.forename: N
authors.initials: N
authors.lastname: Broggini
authors.forename: M
authors.initials: M
authors.lastname: Wieland
authors.forename: R K
authors.initials: RK
authors.lastname: Schenk
authors.forename: A J
authors.initials: AJ
authors.lastname: Denzer
authors.forename: D L
authors.initials: DL
authors.lastname: Cochran
authors.forename: B
authors.initials: B
authors.lastname: Hoffmann
authors.forename: A
authors.initials: A
authors.lastname: Lussi
authors.forename: S G
authors.initials: SG
authors.lastname: Steinemann
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D003758:Dental Implantation, Endosseous / Q000295:instrumentation* / Q000379:methods; D015921:Dental Implants; D017267:Dental Prosthesis Design; D008437:Maxilla / Q000033:anatomy & histology / Q000601:surgery*; D008669:Metallurgy; D016348:Osseointegration / Q000502:physiology*; D013499:Surface Properties; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium / Q000737:chemistry / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D014025:Titanium