Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene.
A Eudragit RL100 polymer nanoparticle system loaded with cloricromene was prepared and characterized on the basis of physicochemical properties, stability and drug release features. To investigate the ocular bioavailability of cloricromene after inclusion in the polymer matrix, the new nanoparticle system was topically administered in the rabbit eye and compared with an aqueous solution of the same drug. The nanoparticle system showed interesting size distribution and surface charge values, suitable for ophthalmic application. The results indicated that the dispersion of cloricromene within Eudragit RL100 polymer nanoparticles increased its ocular bioavailability and enhanced the biopharmaceutical profile. The new cloricromene-loaded nanoparticle system described here may be useful in clinical practice.
Bucolo
Claudio
C
Bausch & Lomb Oftal, C. so Italia 141, I-95127, Catania, Italy.
Maltese
Adriana
A
Maugeri
Francesco
F
Busà
Barbara
B
Puglisi
Giovanni
G
Pignatello
Rosario
R
D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D002866:Chromonar / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000493:pharmacokinetics; D004333:Drug Administration Routes; D016503:Drug Delivery Systems; D004355:Drug Stability; D008297:Male; D036103:Nanotechnology; D010316:Particle Size; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D011817:Rabbits; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical
D000180:Acrylic Resins; D010975:Platelet Aggregation Inhibitors; C050528:Eudragit RS; C025945:cloricromen; D002866:Chromonar