Functional subdivisions within anterior cingulate cortex and their relationship to autonomic nervous system function.
The anterior cingulate cortex (ACC) has diverse functions and several functional subdivisions. This study implemented a counting Stroop task that presented incongruent (INC) and congruent (CON) stimuli at two speeds to probe dorsal (dACC) and ventral (vACC) using functional magnetic resonance imaging (fMRI). Eighteen healthy subjects completed the task twice: once outside the scanner while heart rate variability (HRV) was recorded and once during fMRI. In both sessions, subjects completed two runs. Stimuli were presented every 2.0 s in one run and every 1.5 s in the other. fMRI data analysis revealed two important findings. First, by computing differential activation between INC and CON stimuli, a cluster of activation related to response inhibition was observed in the left dACC. Additionally, by calculating the interaction of speed with stimulus congruency, a cluster of activation was observed in the left vACC. This activation correlated significantly with high-frequency HRV (P < 0.02 for CON and P < 0.003 for INC) and represents the parasympathetic modulatory role of the vACC. This study supports the notion of functional subdivisions within the ACC and links the processes of cognitive interference and parasympathetic modulation with activation in specific subregions of the ACC, a structure that is critical for the interface between cognition and emotion.
Matthews
Scott C
SC
Department of Psychiatry, University of California San Diego, San Diego, CA 92093, USA. scmatthew@ucsd.edu
Paulus
Martin P
MP
Simmons
Alan N
AN
Nelesen
Richard A
RA
Dimsdale
Joel E
JE
D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time