title: 4'-alpha-C-Branched N,O-nucleosides: synthesis and biological properties.
abstract: The synthesis of 4'-alpha-C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells.
authors.affiliation: Dipartimento Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Chiacchio
authors.forename: Filippo
authors.initials: F
authors.lastname: Genovese
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannazzo
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.forename: Paolo
authors.initials: P
authors.lastname: Quadrelli
authors.forename: Corsaro
authors.initials: C
authors.lastname: Antonino
authors.forename: Roberto
authors.initials: R
authors.lastname: Romeo
authors.forename: Vincenza
authors.initials: V
authors.lastname: Valveri
authors.forename: Antonio
authors.initials: A
authors.lastname: Mastino
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides