Recurrent parotitis in selective IgA deficiency.
Recurrent parotitis is an uncommon condition in children. In most cases the etiology is unknown, although the disease is occasionally associated with viral infections, autoimmune disorders and immunodeficiency. We describe, for the first time, a child with recurrent parotitis and isolated immunoglobulin A (IgA) deficiency, without autoimmune disease. As IgA is the main immunoglobulin secreted into the mucosal surfaces, including that of the respiratory and gastrointestinal tracts, and into the saliva, the lack of IgA may be involved in the pathogenesis of recurrent parotitis. We recommend that IgA and other immunoglobulins be tested in all cases of recurrent parotitis.
Shkalim
Vered
V
Department of Pediatrics B, Schneider Children's Medical Cneter of Israel, Petah Tiqva, Israel.
Monselise
Yehudit
Y
Mosseri
Ronen
R
Finkelstein
Yaron
Y
Garty
Ben Zion
BZ
D002648:Child; D006801:Humans; D017098:IgA Deficiency / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D010309:Parotitis / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D012008:Recurrence
D007070:Immunoglobulin A