Study of mitochondrial DNA mutations in patients with migraine with prolonged aura.
Ten patients with migraine with prolonged aura were studied for the presence of mitochondrial DNA point mutations utilizing DNA isolated from blood and hair samples. We analyzed for nine point mutations reported in patients with MELAS (A3243G, C3256T, T3271C, T3291C, A5814G, T8356C, T9957C, G13513A, and A13514G) and three secondary LHON mutations (T4216C, A4917G, and G13708A). None of the patients tested had any of these mutations in mitochondrial DNA. However, one patient was found to have a tRNA(Gln) A4336G mitochondrial DNA variant. From this study it appears that migraine with prolonged aura is not an oligosymptomatic form of MELAS and is not related to secondary LHON mutations. The significance of the tRNA A4336G variant is unknown.
Rozen
Todd D
TD
Department of Neurology, Michigan Head-Pain and Neurological Institute, Ann Arbor 48104, USA.
Shanske
Sara
S
Otaegui
David
D
Lu
Jiesheng
J
Young
William B
WB
Bradley
Kathy
K
DiMauro
Salvatore
S
Silberstein
Stephen D
SD
D001483:Base Sequence; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D020325:Migraine with Aura / Q000235:genetics* / Q000473:pathology; D017354:Point Mutation; D012351:RNA, Transfer, Gln / Q000235:genetics; D013997:Time Factors
D004272:DNA, Mitochondrial; D012351:RNA, Transfer, Gln