title: Thalidomide sensory neurotoxicity: a clinical and neurophysiologic study.
abstract: The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.
authors.affiliation: Dipartimento di Neuroscienze e Tecnologie Biomediche, Università di Milano Bicocca, Monza, Italia. guido.cavaletti@unimib.it
authors.forename: G
authors.initials: G
authors.lastname: Cavaletti
authors.forename: A
authors.initials: A
authors.lastname: Beronio
authors.forename: L
authors.initials: L
authors.lastname: Reni
authors.forename: E
authors.initials: E
authors.lastname: Ghiglione
authors.forename: A
authors.initials: A
authors.lastname: Schenone
authors.forename: C
authors.initials: C
authors.lastname: Briani
authors.forename: G
authors.initials: G
authors.lastname: Zara
authors.forename: D
authors.initials: D
authors.lastname: Cocito
authors.forename: G
authors.initials: G
authors.lastname: Isoardo
authors.forename: P
authors.initials: P
authors.lastname: Ciaramitaro
authors.forename: R
authors.initials: R
authors.lastname: Plasmati
authors.forename: F
authors.initials: F
authors.lastname: Pastorelli
authors.forename: M
authors.initials: M
authors.lastname: Frigo
authors.forename: M
authors.initials: M
authors.lastname: Piatti
authors.forename: M
authors.initials: M
authors.lastname: Carpo
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*; D013792:Thalidomide / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D013792:Thalidomide