Hepatocellular adenoma and focal nodular hyperplasia after long-term use of danazol for endometriosis: a case report.
Danazol, an inhibitor of pituitary gonadotropin with weak androgenic effect, is currently being used for the treatment of endometriosis. In contrast to other C17 alkylated anabolic steroids, it has been rarely associated with the occurrence of primary liver tumors. We present the case of a patient with endometriosis in whom a hepatocellular adenoma was discovered after 14 years of treatment with danazol for endometriosis. The patient showed no clinical signs of a liver tumor and it was only detected by ultrasonography and magnetic resonance imaging (MRI). When long-term danazol therapy is required, regular ultrasonography for monitoring and early tumor detection is recommended.
Bartley
Julia
J
Endometriosis Research Center Berlin, Department of Obstetrics and Gynecology, University Hospital Benjamin Franklin, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany.
Loddenkemper
Christoph
C
Lange
Julia
J
Mechsner
Sylvia
S
Radke
Cornelia
C
Neuhaus
Peter
P
Ebert
Andreas D
AD
D018248:Adenoma, Liver Cell / Q000139:chemically induced / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D003613:Danazol / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D004715:Endometriosis / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D014463:Ultrasonography
D004965:Estrogen Antagonists; D003613:Danazol