The impact of neuraminidase on apoptosis in cultures of blood lymphocytes isolated from rats bearing morris hepatoma.
Lymphocytes were obtained by heart-punction from rats bearing Morris hepatoma. In the short term, 18-hour cultures of these lymphocytes exhibited a significantly higher amount of apoptotic cells than lymphocyte cultures from the healthy, control animals. Neuraminidase, injected into the caudal vein of the rats with Morris hepatoma, caused a marked lowering in the amount of apoptotic blood-lymphocytes and an elevation of the amount of viable cells. The possible mechanism of neuraminidase preventing the apoptosis of blood-circulating lymphocytes in tumour hosts is discussed herein.
Gasiorowski
Kazimierz
K
Department of Basic Medical Sciences, Wrocław Medical University, Kochanowskiego 14, 51-601 Wrocław, Poland.
Steciwko
Andrzej
A
Grata-Borkowska
Urszula
U
Drobnik
Jarosław
J
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D009439:Neuraminidase / Q000494:pharmacology*; D051381:Rats; D011915:Rats, Inbred BUF
D009439:Neuraminidase