Protein recognition using synthetic surface-targeted agents.
The design of synthetic agents to disrupt protein-protein interactions has received relatively little attention in recent years. In this review we describe strategies for targeting different types of protein surfaces using mimetics of protein secondary or tertiary structure. In this way strong and selective binding to a protein surface has be achieved and disruption of clinically important protein-protein interactions has been demonstrated in models of human disease.
Jain
Rishi
R
Department of Chemistry, Yale University, New Haven, CT, USA.
Ernst
Justin T
JT
Kutzki
Olaf
O
Park
Hyung Soon
HS
Hamilton
Andrew D
AD
D000595:Amino Acid Sequence; D001671:Biochemistry / Q000379:methods*; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism; D003578:Cytochrome-c Peroxidase / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D045304:Cytochromes c / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D009930:Organic Chemicals / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010982:Platelet-Derived Growth Factor / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism
D009930:Organic Chemicals; D010982:Platelet-Derived Growth Factor; D011506:Proteins; D045304:Cytochromes c; D003578:Cytochrome-c Peroxidase; D017479:Receptors, Platelet-Derived Growth Factor; D002918:Chymotrypsin