title: S100A7 and the progression of breast cancer.
abstract: The S100 gene family comprises more than 20 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. The expression of individual family members is not ubiquitous for all tissues and there appears to be an element of tissue-specific expression. Molecular analysis of breast tumors has revealed that several S100s, including S100A2, S100A4 and S100A7, exhibit altered expression levels during breast tumorigenesis and/or progression. Subsequent studies have started to describe a functional role for these S100 proteins as well as their mechanism of action and the biochemical pathways they modify. The present review outlines what is known about S100A7 in breast cancer and summarizes the need to better understand the importance of this protein in breast cancer.
authors.affiliation: Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada. umember0@cc.umanitoba.ca
authors.forename: Ethan D
authors.initials: ED
authors.lastname: Emberley
authors.forename: Leigh C
authors.initials: LC
authors.lastname: Murphy
authors.forename: Peter H
authors.initials: PH
authors.lastname: Watson
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins
chemical_list: D002135:Calcium-Binding Proteins; D000075023:S100 Calcium Binding Protein A7; D009418:S100 Proteins; C089242:S100A7 protein, human