title: [Interstitial pneumonia due to gefitinib followed in detail by high-resolution CT in a patient with adenocarcinoma of the lung].
abstract: We describe the case of a 69-year-old woman with advanced adenocarcinoma of the lung, in whom interstitial pneumonia was induced by gefitinib. The shadow was not clear on chest radiography, but diffuse ground-glass opacity was detected on high-resolution CT. Two treatments with pulse corticosteroids improved the lung injury temporarily. However, it became worse on reduction of the steroids. The improvement and deterioration of the pneumonia had been followed in detail by 8 examinations by high-resolution CT. The ground-glass opacity seen in the CT did not completely disappear or progress rapidly under steroid therapy. The patient died 46 days after the onset of the pneumonia. Autopsy disclosed marked cancerous invasion of the lung, and diffuse alveolar damage was also recognized in parts. The cause of death was considered to be respiratory failure due mainly to cancer progression and additionally to diffuse alveolar damage induced by gefitinib.
authors.affiliation: Department of Internal Medicine, National Minami-Okayama Hospital, 4066 Hayashima-cho, Tsukubo-gun, Okayama 701-0304, Japan.
authors.forename: Nagio
authors.initials: N
authors.lastname: Takigawa
authors.forename: Takuo
authors.initials: T
authors.lastname: Shibayama
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Tada
authors.forename: Noriko
authors.initials: N
authors.lastname: Kawata
authors.forename: Goro
authors.initials: G
authors.lastname: Kimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirano
authors.forename: Chiharu
authors.initials: C
authors.lastname: Okada
authors.forename: Ryo
authors.initials: R
authors.lastname: Soda
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamadori
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D005260:Female; D000077156:Gefitinib; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D008175:Lung Neoplasms / Q000188:drug therapy*; D011799:Quinazolines / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D011799:Quinazolines; D000077156:Gefitinib