[Diagnosis of an initial infratentorial central nervous system B-cell lymphoma during prolonged cortisone medication].
We present a patient with primary central nervous system B-cell lymphoma. He had suffered from slowly developing weight loss and presented to us with disorientation, seizures, and a supranuclear gaze disturbance. The patient was dismissed with the primary diagnosis of autoimmune encephalitis of the brainstem and put on oral corticosteroids. Four months later, his health status had deteriorated, and at that time diagnostic methods pointed to a cerebral lymphoma. Stereotactic biopsy with subsequent immunohistochemistry and polymerase chain reaction analysis revealed a highly malignant B-cell lymphoma of the CNS, despite prolonged corticosteroid treatment. The patient was treated with whole brain radiotherapy.
Buss
A
A
Abteilung für Neurologie, Klinikum der RWTH Aachen. arminbuss@hotmail.com
Assmus
A
A
Weidemann
J
J
Sellhaus
B
B
Lorenzen
J
J
Block
F
F
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D020274:Autoimmune Diseases of the Nervous System / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D004660:Encephalitis / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000532:radiotherapy; D008297:Male
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents