title: Quantitative evaluation of eyelid elasticity using the cutometer SEM575 and its clinical application in assessing the efficacy of tacrolimus ointment treatment in eyelid atopic dermatitis.
abstract: OBJECTIVE
  To study the clinical efficacy of a noninvasive suction device that measures eyelid skin elasticity in the treatment of eyelid atopic dermatitis using tacrolimus (FK-506) ointment.
  
  
  METHODS
  Ten patients with eyelid atopic dermatitis treated with tacrolimus ointment and 10 normal volunteers participated in this study. The cutometer SEM575 was used to quantitatively evaluate eyelid skin elasticity. Severity of the eyelid atopic dermatitis was scored, and comparisons were made before and after treatment.
  
  
  RESULTS
  Skin elasticity of patients with eyelid atopic dermatitis was significantly lower than that of normal volunteers (31.3 +/- 5.2% vs 40.2 +/- 7.8%, respectively). Skin elasticity of patients with eyelid atopic dermatitis improved significantly to 37.5 +/- 6.3% after treatment with tacrolimus ointment. The total severity score for eyelid atopic dermatitis also improved from 2.77 +/- 1.11 to 1.77 +/- 1.15.
  
  
  CONCLUSIONS
  Measurement of skin elasticity using the cutometer SEM575 is a useful and reliable method for objective and quantitative evaluation of eyelid skin condition in patients with eyelid atopic dermatitis. The efficacy of short-term tacrolimus ointment treatment in patients with eyelid atopic dermatitis was confirmed quantitatively using this apparatus.
authors.affiliation: Department of Ophthalmology, Tokyo Dental College, Ichikawa, Chiba, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kawakita
authors.forename: Yoji
authors.initials: Y
authors.lastname: Takano
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano-Kato
authors.forename: Mari
authors.initials: M
authors.lastname: Tanaka
authors.forename: Murat
authors.initials: M
authors.lastname: Dogru
authors.forename: Eiki
authors.initials: E
authors.lastname: Goto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takahashi
authors.forename: Kazumi
authors.initials: K
authors.lastname: Fukagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujishima
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000503:physiopathology*; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation; D004548:Elasticity; D005141:Eyelid Diseases / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009824:Ointments; D012867:Skin / Q000503:physiopathology*; D012879:Skin Physiological Phenomena; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus