title: Experimental inoculation of pregnant swine with type 1 bovine viral diarrhoea virus.
abstract: The ability of bovine viral diarrhoea virus type 1 (BVDV-1) to induce transplacental infection in pigs was evaluated. Control pigs (n = 4) were sham-inoculated while infected pigs (n = 4) were intranasally inoculated with BVDV-1 on day 65 of gestation. Blood samples were tested throughout the study for BVDV and antibody to BVDV. On day 110 of gestation, a Caesarean section was performed. Serum was obtained for virus isolation and antibody determination from all piglets, and all experimental animals were killed. Tissues were collected for virus isolation and histopathology. Bovine viral diarrhoea virus was isolated on days 5 and 7 after infection and seroconversion was demonstrated in all infected gilts; however, BVDV was only isolated from one fetus from an infected pig. Viraemia and seroconversion were demonstrated in the pregnant gilts; however, transplacental infection at day 65 of gestation in the pig was not consistently demonstrated.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5606, USA. pwalz@vet.ksu.edu
authors.forename: P H
authors.initials: PH
authors.lastname: Walz
authors.forename: J C
authors.initials: JC
authors.lastname: Baker
authors.forename: T P
authors.initials: TP
authors.lastname: Mullaney
authors.forename: R K
authors.initials: RK
authors.lastname: Maes
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000635:transmission* / Q000821:virology; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000472:pathogenicity*; D005260:Female; D005333:Fetus / Q000821:virology*; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary*; D011247:Pregnancy; D013552:Swine; D013553:Swine Diseases / Q000635:transmission* / Q000821:virology
chemical_list: D000914:Antibodies, Viral