Molecular genetic and proteomic analysis of synchronous malignant gliomas.
Described is a patient with concurrent discrete gliomas: a pleomorphic xanthoastrocytoma with anaplastic features and an anaplastic oligoastrocytoma. The distinct and morphologically dissimilar tumors demonstrated similar genetic abnormalities by loss of heterozygosity and comparative genome hybridization. Clonality and proteomic analyses highlighted an independent origin for the two tumors. Proteomic methods may prove useful in cases where the differential diagnosis and pathogenetic origin of tumors are uncertain, as well as more globally for its ability to provide insight into specific expression of proteins that may serve as unique markers of tumorigenesis or as novel targets of therapy.
Zhuang
Z
Z
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1414, USA.
Lee
Y-S
YS
Zeng
W
W
Furuta
M
M
Valyi-Nagy
T
T
Johnson
M D
MD
Vnencak-Jones
C L
CL
Woltjer
R L
RL
Weil
R J
RJ
D001932:Brain Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D002874:Chromosome Mapping; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D005910:Glioma / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D019656:Loss of Heterozygosity; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009378:Neoplasms, Multiple Primary / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D009693:Nucleic Acid Hybridization; D020543:Proteome / Q000032:analysis*
D009363:Neoplasm Proteins; D020543:Proteome