Multivariate analysis of cytokine responses identifies distinctive sensitivities to lipopolysaccharide in humans.
We describe methods to identify high and low responders in a whole-blood assay of lipopolysaccharide-stimulated cytokine responses. Two multivariate measures of the cytokine responses both captured high and low responses for each of the four individual cytokines that were assayed.
Duncan
David D
DD
Wyeth Research, Pearl River, NY 10965, USA. d_duncan@att.net
Tiberio
Lorrie
L
Eldridge
John H
JH
D016207:Cytokines / Q000097:blood / Q000187:drug effects*; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D015999:Multivariate Analysis
D016207:Cytokines; D008070:Lipopolysaccharides