title: Short report: High prevalence of multidrug-resistant Plasmodium falciparum malaria in the French territory of Mayotte.
abstract: A drug-resistance survey was conducted in the French territory of Mayotte in the Comorian Islands in the Indian Ocean where malaria is endemic. A high prevalence of resistant Plasmodium falciparum parasites was observed, not only to chloroquine (88%) and pyrimethamine (99%), but more surprisingly to quinine (17%), mefloquine (9%), and amodiaquine (24%). This leaves few treatment alternatives other than artemisine-mefloquine combinations. However, despite notification to French Health authorities three years ago, inadequate treatment (chloroquine plus sulfadoxine-pyrimethamine) is still used in this locality. Thus, people still die of malaria in this remote territory of France.
authors.affiliation: Centre Hospitalier de Mayotte, Mamoudzou, Mayotte, France.
authors.forename: François
authors.initials: F
authors.lastname: Pettinelli
authors.forename: Marie-Edith
authors.initials: ME
authors.lastname: Pettinelli
authors.forename: Philippe
authors.initials: P
authors.lastname: Eldin de Pécoulas
authors.forename: Julie
authors.initials: J
authors.lastname: Millet
authors.forename: Delphine
authors.initials: D
authors.lastname: Michel
authors.forename: Philippe
authors.initials: P
authors.lastname: Brasseur
authors.forename: Pierre
authors.initials: P
authors.lastname: Druilhe
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D017507:Comoros / Q000453:epidemiology; D018432:Drug Resistance, Multiple; D019353:Endemic Diseases; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology* / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D015995:Prevalence
chemical_list: D000962:Antimalarials