Immunoglobulin M-enriched intravenous polyclonal immunoglobulins reduce bacteremia following Klebsiella pneumoniae infection in an acute respiratory distress syndrome rat model.
Mechanical ventilation is known to induce bacterial translocation from the lung into the systemic circulation. This study determined the effect of immunoglobulin M (IgM)-enriched polyclonal immunoglobulins on bacteremia due to ventilation-induced translocation in an acute respiratory distress syndrome (ARDS) rat model with Klebsiella-induced pneumonia. After whole lung lavage, Sprague-Dawley rats intravenously received either a high dose or a low dose of an immunoglobulin preparation, or an albumin solution as control, followed by an intratracheal injection of a Klebsiella pneumoniae solution. Blood colony-forming units (CFUs) in the treatment groups were significantly lower during the 3-hour ventilation period compared to the control group. The authors conclude that IgM-enriched polyclonal immunoglobulins lead to a reduction of bacteria in blood of surfactant-deficient, ventilated rats infected with Klebsiella pneumoniae.
Lachmann
R A
RA
Department of Anesthesiology, Erasmus MC-Faculty, Rotterdam, The Netherlands.
van Kaam
A H L C
AH
Haitsma
J J
JJ
Verbrugge
S J C
SJ
Delreu
F
F
Lachmann
B
B
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D001784:Blood Gas Analysis; D001794:Blood Pressure; D018893:Bronchoalveolar Lavage; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D007106:Immune Sera / Q000008:administration & dosage / Q000276:immunology; D007116:Immunization, Passive; D007075:Immunoglobulin M / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D007711:Klebsiella pneumoniae / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000150:complications*
D000907:Antibodies, Bacterial; D007106:Immune Sera; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous