Manipulating dendritic cell biology for the active immunotherapy of cancer.
Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) that have an unequaled capacity to initiate primary immune responses, including tolerogenic responses. Because of the importance of DCs in the induction and control of immunity, an understanding of their biology is central to the development of potent immunotherapies for cancer, chronic infections, autoimmune disease, and induction of transplantation tolerance. This review discusses recent advances in DC research and the application of this knowledge toward new strategies for the clinical manipulation of DCs for cancer immunotherapy.
O'Neill
David W
DW
New York University School of Medicine, 550 1st Ave, MSB 507, New York, NY 10016, USA.
Adams
Sylvia
S
Bhardwaj
Nina
N
D000818:Animals; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D016233:Immunotherapy, Active; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D014612:Vaccines / Q000276:immunology
D014612:Vaccines