title: Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas.
abstract: During the course of typhoid fever, the usual histologic finding of the liver is "nonspecific reactive hepatitis." Hepatic granuloma (HG) is a rare complication of typhoid fever. We present two cases of typhoid fever with HG and review the relevant literature. Case 1 (a 53-year-old female) was found to have both hepatic and splenic granulomas. This is the first case of typhoid fever with splenic granulomas in the English language literature. Case 2 (a 66-year-old male) developed granulomas in the bone marrow in addition to HG. It should be considered that typhoid fever may lead to granulomas in several organs.
authors.affiliation: Cerrahpasa Medical Faculty, Infectious Diseases and Clinical Microbiology, University of Istanbul, 34303 Aksaray, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Mert
authors.forename: Fehmi
authors.initials: F
authors.lastname: Tabak
authors.forename: Resat
authors.initials: R
authors.lastname: Ozaras
authors.forename: Recep
authors.initials: R
authors.lastname: Ozturk
authors.forename: Hilal
authors.initials: H
authors.lastname: Aki
authors.forename: Yildirim
authors.initials: Y
authors.lastname: Aktuglu
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001855:Bone Marrow Diseases / Q000209:etiology / Q000473:pathology*; D002701:Chloramphenicol; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D035583:Rare Diseases; D012720:Severity of Illness Index; D013158:Splenic Diseases / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D002701:Chloramphenicol