title: HLA-G genotype is associated with fetoplacental growth.
abstract: The human leukocyte antigen (HLA)-G is expressed by extravillous cytotrophoblast cells in the feto-maternal contact zone. Polymorphisms have been described in the HLA-G gene and have been linked with differences in HLA-G mRNA alternative splicing patterns and protein expression. Differences in the isoform profile or the degree of HLA-G expression may influence cytokine production and, thereby, placental and fetal growth. Associations between a 14 bp deletion polymorphism in the 3'UTR part of the HLA-G gene and birth weight in relation to gestational age and placental weight were studied in 47 pregnancies complicated with preeclampsia and 87 with no preeclampsia. An HLA-G genotype homozygous for the presence of the 14 bp sequence polymorphism was significantly associated with increased birth weight in relation to gestational age (one-way analysis of variance; 2 degrees of freedom: p = 0.02) and with placental weight at birth (>38 weeks of gestation; +14 bp/+14 bp vs others; unpaired t-test: p = 0.03). There was also a slightly higher placental ratio in the offspring with the +14 bp/+14 bp genotype. The implications of these findings are discussed in relation to certain complications of pregnancy and in an evolutionary perspective.
authors.affiliation: Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. hviid@dadlnet.dk
authors.forename: Thomas Vauvert
authors.initials: TV
authors.lastname: Hviid
mesh_terms: D017398:Alternative Splicing / Q000235:genetics / Q000276:immunology; D001724:Birth Weight / Q000235:genetics / Q000276:immunology*; D005260:Female; D005333:Fetus / Q000196:embryology / Q000276:immunology*; D005865:Gestational Age; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D006801:Humans; D010920:Placenta / Q000276:immunology*; D010929:Placentation; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics / Q000276:immunology; D011247:Pregnancy; D017384:Sequence Deletion / Q000235:genetics / Q000276:immunology; D014327:Trophoblasts / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I