Electrochemical determination of serotonin and the competitive adsorption with dopamine at 5,5-ditetradecyl-2-(2-trimethylammonioethyl)-1,3-dioxane bromide lipid film modified by glassy carbon electrode.
A novel and effective approach to sensitively determine serotonin, known as 5-hydroxytryptamine (5-HT), has been proposed based on a 5,5-ditetradecyl-2-(2-trimethylammonioethyl)-1,3-dioxane bromide (DTDB) self-assembled lipid bilayer membrane modified glassy carbon electrode (DTDB/GCE). A DTDB/GCE shows the strong electrocatalysis for the oxidation of 5-HT, with the peak potential shifted to less positive value of 0.376 V vs. SCE, and effectively eliminates the interference from ascorbic acid (AA), even in the presence of 100-fold concentration of AA. Differential pulse voltammetry (DPV) gave a linear current for 5-HT from 2.0 x 10(-7) to 1.0 x 10(-5) M. At the DTDB/GCE, the oxidation of 5-HT was controlled by the adsorption process; for 5-HT coexisting with DA, the competitive adsorption was observed.
Gong
Jing-Ming
JM
University of Science and Technology of China, Hefei 230026, PR China.
Lin
Xiang-Qin
XQ
D000327:Adsorption; D002244:Carbon; D004146:Dioxanes / Q000737:chemistry*; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D008055:Lipids / Q000737:chemistry*; D012701:Serotonin / Q000032:analysis* / Q000737:chemistry
C500099:5,5-ditetradecyl-2-(2-trimethylammonioethyl)-1,3-dioxane bromide; D004146:Dioxanes; D008055:Lipids; D012701:Serotonin; D002244:Carbon; D004298:Dopamine