Getting more from IR-microscopy of resin-bound libraries.
A linear pixel-array detector was employed to create spatially resolved multi-layered IR-images of a large collection of polymer beads supporting carbonyl and nitrile monomers. The feasibility of creating multi-layered IR-images with nitrile IR-band separation of 4 cm(-1) was demonstrated, an important issue when considering that many monomers used to develop combinatorial libraries are structurally analogous and therefore occupy very similar positions in the IR-spectrum. Strategies for obtaining high quality spectral data from both imaging and mapping IR-microscopes without compromising on sample area, analysis time, or spatial resolution are also described.
Mandair
Gurjit S
GS
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.
Russell
Andrea E
AE
Aston
Gavin
G
Bradley
Mark
M
D020650:Combinatorial Chemistry Techniques; D007091:Image Processing, Computer-Assisted; D012117:Resins, Synthetic / Q000737:chemistry*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods*
D012117:Resins, Synthetic