title: [An epidemiological study on sexual transmission of human immunodeficiency virus among pre-marital group in Yining city, Xinjiang].
abstract: OBJECTIVE
  To study the human immunodeficiency virus (HIV) status through heterosexual transmission in Yining city and to provide information on effective intervention measures.
  
  
  METHODS
  Cohort of HIV sero-discordant couples identified from 1997 to 2000 was formed. Proportional risk model was used to analyze the time of HIV sero-conversion and the related factors. All the recruiters were under informed consent.
  
  
  RESULTS
  Through following on 22 sero-discordant couples, we found that the incidence density (ID) of HIV sero-conversion was 32.49/100 person-year (PY) with 33.74/100 PY for women. In the proportional hazard model, the course of sero-conversion was only 2.43 years and the frequency of sexual contact was statistically significant (>or= 3 times/week vs. < 3 time/week: RR = 1.984, 95% CI: 1.045 - 3.767), indicating this factor was related to the hazard of HIV sero-conversion. However, the viral load of HIV infections has no such effect on HIV sero-conversion of their spouses. In addition, the ratio of CD4(+)/CD8(+) was lower in spouses of HIV sero-conversion than that in spouses of HIV non-sero conversion (t test: t = 4.77, P < 0.01).
  
  
  CONCLUSIONS
  In order to control HIV transmission among general population, we suggested that HIV/AIDS counseling and testing be developed for pre-marital people in the region with high HIV prevalence.
authors.affiliation: National Center for STD/AIDS Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Yu-rong
authors.initials: YR
authors.lastname: Mao
authors.forename: Xi-wen
authors.initials: XW
authors.lastname: Zheng
authors.forename: Zi-yan
authors.initials: ZY
authors.lastname: Re
authors.forename: Cheng-dong
authors.initials: CD
authors.lastname: Pan
authors.forename: Rou-zi
authors.initials: RZ
authors.lastname: Guli
authors.forename: Jun-qing
authors.initials: JQ
authors.lastname: Song
authors.forename: Li-min
authors.initials: LM
authors.lastname: Yang
authors.forename: Gui-yun
authors.initials: GY
authors.lastname: Zhang
mesh_terms: D015153:Blotting, Western; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D015994:Incidence; D008297:Male; D016016:Proportional Hazards Models; D012725:Sexual Behavior; D015229:Sexually Transmitted Diseases, Viral / Q000453:epidemiology* / Q000276:immunology