title: Evolution of acquired resistance to third-generation cephalosporins in Enterobacteriaceae in a Tunisian hospital 1993-2001.
abstract: Between January 1993 and December 2001, the overall frequency of resistance to third-generation cephalosporins in isolates of Enterobacteriaceae from Charles Nicolle Hospital, Tunis, rose from 2.4% to 7.4%. Klebsiella pneumoniae was the most prevalent species (56%), followed by Escherichia coli (15%) and Proteus mirabilis (9%). A rate of 49% was observed among isolates from paediatric patients in 1999, caused mostly by outbreaks in the neonatal intensive care unit of K. pneumoniae and P. mirabilis isolates that produced extended-spectrum beta-lactamases.
authors.affiliation: Laboratoire de Résistance aux Antibiotiques, Faculté de Médecine, Tunis, Tunisia. ilhem.boutiba@rns.tn
authors.forename: I
authors.initials: I
authors.lastname: Boutiba-Ben Boubaker
authors.forename: R
authors.initials: R
authors.lastname: Ghozzi
authors.forename: H
authors.initials: H
authors.lastname: Ben Abdallah
authors.forename: K
authors.initials: K
authors.lastname: Mamlouk
authors.forename: A
authors.initials: A
authors.lastname: Kamoun
authors.forename: S
authors.initials: S
authors.lastname: Ben Redjeb
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004196:Disease Outbreaks; D004755:Enterobacteriaceae / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D006760:Hospitalization; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects / Q000201:enzymology; D014416:Tunisia / Q000453:epidemiology; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D001618:beta-Lactamases