title: Circulatory effects and kinetics following acute administration of carbon monoxide in a porcine model.
abstract: Carbon monoxide is produced in the endothelial cells and has possible vasodilator activity through three different pathways. The aim of this study was to demonstrate circulatory effects after administration of saturated carbon monoxide blood and to describe the pharmacokinetics of carbon monoxide. Six pigs were anesthetized and 150 ml blood was removed. This blood was bubbled with carbon monoxide until the carboxyhemoglobin (COHb) levels were 90-99%. A specific amount of this blood was then injected back to the animal. At predetermined times; arterial and mixed venous blood was drawn and analyzed for carbon monoxide. Systemic and pulmonary vascular resistance index (SVRi and PVRi) were measured and exhaled air was sampled and measured for carbon monoxide. Blood samples were gathered over 300 minutes along with measurements of invasive pressures, heart rate, cardiac output, oxygen saturation (SpO2), Hb, temperature and blood gases. We conclude that this type of exposure to carbon monoxide appears to have little or no effect on general vasomotor tone and, after correcting for basal levels of carbon monoxide, elimination occurs through the lungs as predicted by a single compartment model. The half-life of carbon monoxide was determined to be 60.5 minutes (SEM 4.7).
authors.affiliation: Department of Surgical and Perioperative Sciences, Division of Anesthesiology and Intensive Care, Umea University Hospital, SE-901 85 Umea, Sweden. annamaja.aberg@anestesi.umu.se
authors.forename: Anna-Maja
authors.initials: AM
authors.lastname: Aberg
authors.forename: Magnus
authors.initials: M
authors.lastname: Hultin
authors.forename: Pernilla
authors.initials: P
authors.lastname: Abrahamsson
authors.forename: Jan Erik
authors.initials: JE
authors.lastname: Larsson
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001831:Body Temperature / Q000187:drug effects; D002248:Carbon Monoxide / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology*; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000503:physiopathology*; D002302:Cardiac Output / Q000187:drug effects; D002860:Chromium Radioisotopes / Q000097:blood; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006454:Hemoglobins / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D034421:Sus scrofa; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology
chemical_list: D002860:Chromium Radioisotopes; D006454:Hemoglobins; D002248:Carbon Monoxide; D010100:Oxygen