Kowalski ester homologation. application to the synthesis of beta-amino esters.
The Kowalski ester homologation protocol has been applied to a representative range of alpha-amino esters to provide beta-amino esters with excellent levels of enantio- and diastereocontrol. A key feature of this chemistry is the nature of the N-protecting group that is employed.
Gray
Diane
D
School of Chemistry, University of Bristol, Bristol BS8 1TS, UK.
Concellón
Carmen
C
Gallagher
Timothy
T