title: Lack of Arg972 polymorphism in the IRS1 gene in Parakanã Brazilian Indians.
abstract: Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly --> Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 polymorphism in Parakanã Indians and found a lack of this polymorphism in the Parakanã population.
authors.affiliation: Departamento de Clínica Médica, FCM-UNICAMP, Campinas, SP Brazil 13081-970.
authors.forename: Rosângela M N
authors.initials: RM
authors.lastname: Bezerra
authors.forename: Thiago T
authors.initials: TT
authors.lastname: Chadid
authors.forename: Claúdia M
authors.initials: CM
authors.lastname: Altemani
authors.forename: Teresa S I
authors.initials: TS
authors.lastname: Sales
authors.forename: Raimundo
authors.initials: R
authors.lastname: Menezes
authors.forename: Manoel C P
authors.initials: MC
authors.lastname: Soares
authors.forename: Sara T O
authors.initials: ST
authors.lastname: Saad
authors.forename: Mario J A
authors.initials: MJ
authors.lastname: Saad
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003241:Consanguinity; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics*; D007962:Leukocytes; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D015995:Prevalence; D012934:Social Isolation