Risks of interleukin-1 genetic polymorphisms and Helicobacter pylori infection in the development of gastric cancer.
BACKGROUND
The host genetic factors that determine the clinical outcomes of Helicobacter pylori-infected individuals remain unclear.


OBJECTIVE
To elucidate the risks of host interleukin-1 (IL-1) genetic polymorphisms and H. pylori infection in the development of gastric cancer.


METHODS
In a case-control study of 164 controls and 142 patients with gastric cancer, the IL-1B-511 biallelic polymorphisms and the IL-1RN penta-allelic variable number of tandem repeats were genotyped.


RESULTS
The carriage of IL-1RN*2, male gender, old age and H. pylori infection independently increased the risk of gastric cancer, with odds ratios of 3.3 [95% confidence interval (CI), 1.4-7.7], 2.1 (95% CI, 1.2-3.8), 5.3 (95% CI, 3.1-9.0) and 2.2 (95% CI, 1.3-3.8), respectively. H. pylori-infected individuals who were carriers of IL-1RN*2 showed increased risks of both intestinal and diffuse types of gastric cancer, with odds ratios of 11.0 and 8.7, respectively. In addition, these individuals also had a higher score of intestinal metaplasia in the corpus than did uninfected non-carriers.


CONCLUSIONS
This study is the first to verify IL-1RN*2 as an independent factor governing the development of gastric cancer in Asian individuals. A combination of H. pylori testing and host genotyping may target the eradication of H. pylori to high-risk individuals.
Chen
A
A
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Li
C-N
CN
Hsu
P-I
PI
Lai
K-H
KH
Tseng
H-H
HH
Hsu
P-N
PN
Lo
G-H
GH
Lo
C-C
CC
Lin
C-K
CK
Hwang
I-R
IR
Yamaoka
Y
Y
Chen
H-C
HC
D000230:Adenocarcinoma / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000235:genetics*; D016480:Helicobacter pylori / Q000235:genetics*; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000382:microbiology
D007375:Interleukin-1