Psychotherapy alone and combined with pharmacotherapy in the treatment of depression.
BACKGROUND
The relative efficacy of psychotherapy and combined therapy in the treatment of depression is still a matter of debate.


OBJECTIVE
To investigate whether combined therapy has advantages over psychotherapy alone.


METHODS
A 6-month randomised clinical trial compared Short Psychodynamic Supportive Psychotherapy (n=106) with combined therapy (n=85) in ambulatory patients with mild or moderate major depressive disorder diagnosed using DSM-IV criteria. Antidepressants were prescribed according to a protocol providing four successive steps in case of intolerance or inefficacy: venlafaxine, selective serotonin reuptake inhibitor, nortriptyline and nortriptyline plus lithium. Efficacy was assessed using the 17-item Hamilton Rating Scale for Depression, the Clinical Global Impression of Severity and of Improvement, and the depression sub-scale of the Symptom Checklist.


RESULTS
The advantages of combining antidepressants with psychotherapy were equivocal. Neither the treating clinicians nor the independent observers were able to ascertain them, but the patients experienced them clearly.


CONCLUSIONS
The advantages of combining antidepressants with psychotherapy are equivocal.
de Jonghe
Frans
F
Department of Psychiatry, University of Amsterdam, and Depression Research Group, Mentrum Institute for Mental Health, The Netherlands.
Hendricksen
Mariëlle
M
van Aalst
Gerda
G
Kool
Simone
S
Peen
Vjaap
V
Van
Rien
R
van den Eijnden
Ellen
E
Dekker
Jack
J
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000188:drug therapy / Q000628:therapy*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011614:Psychotherapy, Brief; D016896:Treatment Outcome
D000928:Antidepressive Agents