title: Diacylglycerol kinases.
abstract: Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol kinases. By modulating the activity of these proteins, DGKs potentially affect a number of biological events including-but likely not limited to-cell growth, neuronal transmission, and cytoskeleton remodeling.
authors.affiliation: The Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA.
authors.forename: Bai
authors.initials: B
authors.lastname: Luo
authors.forename: Debra S
authors.initials: DS
authors.lastname: Regier
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Prescott
authors.forename: Matthew K
authors.initials: MK
authors.lastname: Topham
mesh_terms: D000818:Animals; D019852:Diacylglycerol Kinase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D010712:Phosphatidic Acids / Q000096:biosynthesis / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D010712:Phosphatidic Acids; D019852:Diacylglycerol Kinase