title: [Immune restoration inflammatory syndromes].
abstract: Increase of prevalence of certain immunodeficiencies is caused by more frequent use of immunosuppresive treatment, by advances in supportive care of immunodeficient individuals and by the pandemic spread of HIV-infection respectively. Highly active antiretroviral treatment (HAART) is able to reconstitute the impaired immunity in the HIV-infected individual and therefore to reduce morbidity and mortality. On the other hand paradoxical exacerbation of inflammatory or opportunistic diseases may develop during immunoreconstitution. By their distinct pathophysiological, clinical and therapeutic particularities these disease have been summarized as Immune Restoration Inflammatory Syndromes (IRIS). This review summarizes the variety of immunoreconstitution disorders and describes possible diagnostic pitfalls. Potential therapeutic options and an algorithm for the classification of the syndrome are proposed.
authors.affiliation: Abteilung Klinische Immunologie, Medizinische Hochschule Hannover. stoll.matthias@mh-hannover.de
authors.forename: M
authors.initials: M
authors.lastname: Stoll
authors.forename: H
authors.initials: H
authors.lastname: Heiken
authors.forename: G M N
authors.initials: GM
authors.lastname: Behrens
authors.forename: R E
authors.initials: RE
authors.lastname: Schmidt
mesh_terms: D000465:Algorithms; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000628:therapy; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000276:immunology / Q000628:therapy*; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007167:Immunotherapy / Q000009:adverse effects*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology