[Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children].
OBJECTIVE
To study the association of dopamine beta-hydroxylase gene 5' flanking region polymorphism-1021 C-->T with attention deficit hyperactivity disorder (ADHD) in Han children.


METHODS
ADHD was diagnosed according to the DSM-IV criteria. DNA was extracted and PCR was performed to examine the DBH-1021C-->T polymorphism. HHRR was used to test the association of dopamine beta-hydroxylase gene with different subtypes of ADHD.


RESULTS
HHRR results showed this polymorphism had a tendency to be associated with the inattention subtype (P=0.067) and the combined subtype (P=0.076). The T allele was the protective factor of the inattentive subtype (P=0.07), and the risk factor of the combined subtype (P=0.08). After dividing the 292 nuclear families according to sex, DBH-1021C-->T polymorphism was found to be associated with the combined subtype (P=0.04) with the T allele as the risk factor (P=0.02). There were no positive findings among the girl nuclear families of ADHD.


CONCLUSIONS
DBH gene is related to ADHD combined subtype and inattention subtype. The genetic basis of ADHD combined subtype and is inattention is different, and is influenced by sex factor.
Zhang
Hao-bo
HB
Mental Health Institute of Peking University, Beijing 100083, China.
Wang
Yu-feng
YF
Li
Jun
J
Wang
Bing
B
Yang
Li
L
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002648:Child; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D012737:Sex Factors
D004299:Dopamine beta-Hydroxylase