title: [Preoperative brachytherapy for clinical stage I and II endometrial carcinoma: results from a series of 780 patients with a 10-year follow-up].
abstract: OBJECTIVE
  Retrospective analysis of patients treated by preoperative brachytherapy for endometrial carcinoma.
  
  
  METHODS
  From 1973 to 1994, 780 consecutive patients with a clinical stage I-II endometrial carcinoma were treated with brachytherapy followed by surgery and pelvic irradiation if necessary. Tumour was staged according to 1979 UICC classification. There were 462 T1a, 257 T1b, and 61 T2, 62% were well differentiated. Brachytherapy consisted in one low dose rate endocavitary application. Sixty grays were delivered on the reference isodose. Surgery consisted in a TAH/BSO (Piver II) and was performed 6 weeks later. Nodal pelvic irradiation was indicated in case of unfavourable pathological prognostic factors.
  
  
  RESULTS
  Median follow up was 122 months. Five year survival rates were: 84% for overall survival, 86% for survival without recurrence, 92.8% for local control, and 3.8% for late complications. Pronostic factors were age, stage, differentiation, grade and postoperative extension. Multivariate analysis showed only age, differentiation and postoperative extension to be independent prognostic factors.
  
  
  CONCLUSIONS
  If for stage 1, initial surgery has now replaced preoperative brachytherapy in most cases because it allows to identify initial prognostic factors, preoperative brachytherapy remains the most interesting option for stage 2 endometrial carcinomas.
authors.affiliation: Service de radiothérapie-curiethérapie, centre Alexis-Vautrin, avenue de Bourgogne, 54511 Vandoeuvre-les-Nancy, France. s.hoffstetter@nancy.fnclcc.fr
authors.forename: S
authors.initials: S
authors.lastname: Hoffstetter
authors.forename: C
authors.initials: C
authors.lastname: Brunaud
authors.forename: C
authors.initials: C
authors.lastname: Marchal
authors.forename: E
authors.initials: E
authors.lastname: Luporsi
authors.forename: F
authors.initials: F
authors.lastname: Guillemin
authors.forename: A
authors.initials: A
authors.lastname: Leroux
authors.forename: P
authors.initials: P
authors.lastname: Bey
authors.forename: D
authors.initials: D
authors.lastname: Peiffert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002277:Carcinoma / Q000532:radiotherapy* / Q000601:surgery; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome