In vitro interactions of approved and novel drugs against Paecilomyces spp.
We have evaluated the in vitro activity of 15 combinations of antifungal drugs (amphotericin B, itraconazole, voriconazole, albaconazole, ravuconazole, terbinafine, and micafungin) against four isolates of Paecilomyces variotii and three of P. lilacinus. The interaction of terbinafine with the four azoles was synergistic for 53% of the combinations, while the interactions of both amphotericin B and micafungin with the rest of antifungal agents were mainly indifferent.
Ortoneda
Montserrat
M
Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
Capilla
Javier
J
Pastor
F Javier
FJ
Pujol
Isabel
I
Yustes
Clara
C
Serena
Carolina
C
Guarro
Josep
J
D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D009281:Naphthalenes / Q000494:pharmacology; D010143:Paecilomyces / Q000187:drug effects*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine