Dose response of the AIA rabbit stifle joint to boron neutron capture synovectomy.
This study assessed the treatment with boron neutron capture synovectomy of synovitis in the antigen-induced arthritis (AIA) model. A boron compound, potassium dodecahydrododeca-borate (K(2)B(12)H(12)), was injected into stifle joints of 24 AIA and 12 normal rabbits and activated by neutron bombardment of the joint to achieve doses from 800 to 81,000 RBE-cGy. Synovial ablation in the AIA joint was accomplished at doses of 6,000 to 7,000 RBE-cGy with no adverse effects to skin or extracapsular tissues.
Shortkroff
Sonya
S
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. sshortkroff@rics.bwh.harvard.edu
Binello
Emanuela
E
Zhu
Xuping
X
Gierga
David
D
Thornhill
Thomas S
TS
Shefer
Ruth E
RE
Jones
Alun G
AG
Yanch
Jacquelyn C
JC
D000818:Animals; D000941:Antigens; D001881:Borates / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000009:adverse effects / Q000379:methods*; D002356:Cartilage / Q000293:injuries / Q000528:radiation effects; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D008297:Male; D011817:Rabbits; D011832:Radiation Injuries / Q000209:etiology; D011879:Radiotherapy Dosage; D012720:Severity of Illness Index; D012867:Skin / Q000293:injuries / Q000528:radiation effects; D013264:Stifle / Q000473:pathology* / Q000528:radiation effects*; D013585:Synovitis / Q000139:chemically induced / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome
D000941:Antigens; D001881:Borates