title: Serum matrix metalloproteinase-9 is elevated in men with a history of myocardial infarction.
abstract: Elevated serum inflammatory markers have been reported in coronary heart disease. Levels of serum matrix metalloproteinase-9 (MMP-9), C-reactive protein (CRP), C3-complement (C3) and autoantibodies against oxidized low-density lipoprotein (oxLDL) in 120 male subjects with a history of myocardial infarction (MI) were compared with those in 250 age-matched controls, both groups from a large cross-sectional population survey, the FINRISK study. The concentrations of serum MMP-9 and autoantibodies against oxLDL were measured by enzyme-linked immunosorbent assay, CRP and C3 by immunonephelometry. MMP-9, CRP and C3 concentrations were higher in the subjects with a history of MI than in the controls (p=0.037, p=0.004, and p=0.006, respectively). There was no difference between the groups in serum levels of autoantibodies against oxLDL. In other background characteristics, men in the MI group had higher body mass index (BMI) and serum triglyceride values and lower serum HDL cholesterol values compared to controls (p=0.009, p=0.001, and p<0.001, respectively). When analyzed by stepwise multiple logistic regression using BMI, HDL cholesterol, triglycerides, CRP, C3 and MMP-9 as independent variables, the significant predictors for MI were HDL cholesterol (p=0.002) and MMP-9 (p=0.015). These results suggest that increased serum MMP-9 may reflect inflammatory pathologic processes that are related to progression of atherosclerosis.
authors.affiliation: Department of Medical Biochemistry, University of Tampere, Medical School, Tampere, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Renko
authors.forename: A
authors.initials: A
authors.lastname: Kalela
authors.forename: O
authors.initials: O
authors.lastname: Jaakkola
authors.forename: S
authors.initials: S
authors.lastname: Laine
authors.forename: M
authors.initials: M
authors.lastname: Höyhtyä
authors.forename: H
authors.initials: H
authors.lastname: Alho
authors.forename: S T
authors.initials: ST
authors.lastname: Nikkari
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003176:Complement C3 / Q000032:analysis; D003430:Cross-Sectional Studies; D005387:Finland; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology; D016015:Logistic Models; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D012907:Smoking; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D001323:Autoantibodies; D008076:Cholesterol, HDL; D003176:Complement C3; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein; D002784:Cholesterol; D020780:Matrix Metalloproteinase 9