title: Insular carcinoma of the thyroid with jugular vein invasion.
abstract: BACKGROUND
  Gross angioinvasion with intraluminal tumor thrombus is rarely seen in thyroid cancer, with few cases reported in the literature.
  
  
  METHODS
  We report an insular carcinoma of the thyroid displaying this aggressive local invasion and angioinvasion of the internal jugular chain. Complete surgical removal of the intraluminal disease, regional metastasis, and primary tumor was carried out.
  
  
  RESULTS
  Adjuvant external beam radiation therapy and iodine-131 were administered, and the patient died with pulmonary metastases 30 months after surgery. No locoregional recurrence was noted at last follow-up.
  
  
  CONCLUSIONS
  Treatment of insular carcinoma of the thyroid with invasion of the internal jugular vein is amenable to surgical resection. Postoperative radioactive iodine and external beam radiotherapy can achieve locoregional disease control and prolonged survival.
authors.affiliation: Department of Otolaryngology, National University Hospital, Republic of Singapore.
authors.forename: Jern-Lin
authors.initials: JL
authors.lastname: Leong
authors.forename: Heng Wai
authors.initials: HW
authors.lastname: Yuen
authors.forename: Virginia A
authors.initials: VA
authors.lastname: LiVolsi
authors.forename: Laurie
authors.initials: L
authors.lastname: Loevner
authors.forename: Navneet
authors.initials: N
authors.lastname: Narula
authors.forename: Zubair
authors.initials: Z
authors.lastname: Baloch
authors.forename: Randal S
authors.initials: RS
authors.lastname: Weber
mesh_terms: D000368:Aged; D018265:Carcinoma, Papillary, Follicular / Q000150:complications / Q000473:pathology* / Q000601:surgery; D003680:Deglutition Disorders / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D007601:Jugular Veins / Q000473:pathology*; D008175:Lung Neoplasms / Q000601:surgery; D008197:Lymph Node Excision; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D010166:Palliative Care; D013964:Thyroid Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy