title: Immunohistochemistry for the differentiation of peritoneal disseminated carcinoma of unknown origin.
abstract: We report a woman with ascites, hydrothorax, pancreatic tumor, left cystic ovarian tumor, and an elevated serum cancer antigen 125 level. Exploratory laparotomy was performed to determine peritoneal disseminated carcinoma of unknown origin. Immunohistochemical analysis demonstrated positive staining for carcinoembryonic antigen, trypsin, and progesterone receptor and nonspecific or negative reaction for calretinin, estrogen receptor, amylase, lipase, Wilms tumor gene 1 protein, and inhibin or chromogranin A. These results together with the morphology of tubular structure suggested the pathological diagnosis of adenocarcinoma with pancreatic characteristics and contradicted ovarian cancer or mesothelioma. Immunohistochemistry is an adjunct tool to differentiate the primary site of carcinomatous peritonitis.
authors.affiliation: Department of Respiratory Medicine, Tokyo Metropolitan Koto Geriatric Medical Center, 3-3-20 Shinsuna, Koto-ku, Tokyo 136-0075.
authors.forename: Tae
authors.initials: T
authors.lastname: Sato
authors.forename: Akihiko
authors.initials: A
authors.lastname: Ohwada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Miyaji
authors.forename: Ryoichiro
authors.initials: R
authors.lastname: Miyazaki
authors.forename: Masaru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D018394:CA-125 Antigen / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007813:Laparotomy / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009382:Neoplasms, Unknown Primary / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D010538:Peritonitis / Q000175:diagnosis; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen