Update on laser subepithelial keratectomy (LASEK).
OBJECTIVE
This study reviews current concepts in laser subepithelial keratectomy (LASEK), variations in LASEK techniques, the role of pharmacology in LASEK, and optimizing outcomes in LASEK.


RESULTS
Recent studies continue to support the use of LASEK over that of LASIK in the correction of refractive error. In addition, the advent of pharmacological/biologic intervention, improved algorithms, and wavefront technology have expanded the armamentarium available to ophthalmologists in the maximization of LASEK outcomes.


CONCLUSIONS
LASEK offers an excellent profile in terms of both final outcome (uncorrected visual acuity) and safety (best corrected visual acuity). Untoward effects of LASEK are readily prevented/treated with a variety of agents. Postoperative pain can be ameliorated using topical and oral analgesia. Infection can be most effectively addressed with the fourth generation of fluoroquinolones. Haze may be treated or prevented using numerous remedies namely autologous serum, steroids, ascorbic acid, mitomycin-c, and NSAIDS. Wavefront combined with LASEK rather than with LASIK may offer the best refractive outcome.
Yee
Richard W
RW
Hermann Eye Center, Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. richard.w.yee@uth.tmc.edu
Yee
Steven B
SB
D006801:Humans; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer; D018903:Photorefractive Keratectomy / Q000009:adverse effects / Q000379:methods / Q000592:standards; D011183:Postoperative Complications / Q000517:prevention & control / Q000628:therapy; D012030:Refractive Errors / Q000503:physiopathology; D054140:Refractive Surgical Procedures; D014792:Visual Acuity