title: Topical application of the tricyclic antidepressant doxepin can reduce dysuria and frequency.
abstract: The aim of this article is to highlight a novel treatment for the symptoms of chronic urethral and trigonal irritation. A patient with severe urethral hyperaesthesia who derived almost complete alleviation of symptoms with topical application of a tricyclic antidepressant cream is described. The possible modes of action of tricyclics when used via the topical route of administration are described. Topical application of a tricyclic antidepressant cream may alleviate the symptoms of urethral hyperaesthesia.
authors.affiliation: Rampark Pain Centre, Lurgan, UK. gary@mccleane.freeserve.co.uk
authors.forename: Gary
authors.initials: G
authors.lastname: McCleane
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004316:Doxepin / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D001750:Urinary Bladder, Neurogenic / Q000150:complications / Q000175:diagnosis*; D014546:Urinary Catheterization; D014555:Urination Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D014563:Urodynamics
chemical_list: D000929:Antidepressive Agents, Tricyclic; D004316:Doxepin