Micafungin enhances neutrophil fungicidal functions against Candida pseudohyphae.
We evaluated the effect of the combination of micafungin and polymorphonuclear leukocytes (PMN) against hyphae of Candida albicans and Candida dubliniensis. Micafungin enhanced the PMN oxidative burst dose dependently. The combination was synergistic (C. albicans) or additive (C. dubliniensis); when PMN were pretreated with granulocyte-macrophage colony-stimulating factor, the combination was more effective.
Gil-Lamaignere
Cristina
C
Department of Pediatrics III, Pediatric Pulmonology and Infectious Diseases, University of Heidelberg, Im Neuenheimer Feld 153, D-69120 Heidelberg, Germany. cris.gil@med.uni-heidelberg.de
Salvenmoser
Stefanie
S
Hess
Regina
R
Müller
Frank-Michael C
FM
D002175:Candida / Q000187:drug effects*; D054714:Echinocandins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D025301:Hyphae / Q000187:drug effects*; D066298:In Vitro Techniques; D055666:Lipopeptides; D008074:Lipoproteins / Q000494:pharmacology*; D000077551:Micafungin; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D016897:Respiratory Burst / Q000187:drug effects; D013268:Stimulation, Chemical; D013481:Superoxides / Q000378:metabolism
D054714:Echinocandins; D055666:Lipopeptides; D008074:Lipoproteins; D010456:Peptides, Cyclic; D013481:Superoxides; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000077551:Micafungin