Antioxidant iridoid glucosides from Wendlandia formosana.
Two new iridoid glucosides of 10-O-caffeoyl scandoside methyl ester (3), and 6-methoxy scandoside methyl ester (4) besides the known compounds of scandoside methyl ester (1), methyl deacetyl asperulosidate (2), 10-O-caffeoyl daphylloside (5), phytol (6), and ursolic acid (7) were isolated from the leaves of Wendlandia formosana. Structure elucidation of the new iridoid glucosides was based on interpretation of high-resolution 1D and 2D NMR spectral data and chemical conversions. Antioxidant activity of Compounds (1-5) against diphenylpicrylhydrazyl (DPPH) and hydroxyl radical, and peroxynitrite was reported.
Raju
B Lakshmana
BL
Department of Medicinal Chemistry, School of Pharmacy, Taipei Medical University, No. 250, Wu-Hsing Street, Taipei 110-31, Taiwan, ROC.
Lin
Shwu-Jiuan
SJ
Hou
Wen-Chi
WC
Lai
Zhi-Yang
ZY
Liu
Pan-Chun
PC
Hsu
Feng-Lin
FL
D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001713:Biphenyl Compounds; D006801:Humans; D039823:Iridoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D019666:Rubiaceae
D000975:Antioxidants; D001713:Biphenyl Compounds; D039823:Iridoids; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl