title: Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae.
abstract: The methylene chloride extract of the root of Angelicae dahuricae showed high protective activity against 2,2'-azobis (2-aminodinopropane) dihydrochloride (AAPH)-induced cellular damage. From this extract, 11 furanocoumarins were isolated, namely oxypeucedanin hydrate, 9-hydroxy-4-methoxypsoralen, byakangelicin, pabulenol, alloisoimperatorin, neobyakangelicol, byakangelicol, oxypeucedanin, imperatorin, phellotorin and isoimperatorin, respectively. Among these 11 furanocoumarins, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin displayed potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro.
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
authors.forename: Xiang Lan
authors.initials: XL
authors.lastname: Piao
authors.forename: Il Ho
authors.initials: IH
authors.lastname: Park
authors.forename: Seung Hoon
authors.initials: SH
authors.lastname: Baek
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Man Ki
authors.initials: MK
authors.lastname: Park
authors.forename: Jeong Hill
authors.initials: JH
authors.lastname: Park
mesh_terms: D000578:Amidines; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019661:Apiaceae; D001713:Biphenyl Compounds; D002470:Cell Survival / Q000187:drug effects; D011564:Furocoumarins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018374:LLC-PK1 Cells / Q000187:drug effects; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D013552:Swine
chemical_list: D000578:Amidines; D000975:Antioxidants; D001713:Biphenyl Compounds; D011564:Furocoumarins; D010851:Picrates; D010936:Plant Extracts; C046728:2,2'-azobis(2-amidinopropane); C004931:1,1-diphenyl-2-picrylhydrazyl