MMP-9 microsatellite polymorphism and multiple sclerosis.
A polymorphism (PM) in the microsatellite of the promoter region of matrix metalloproteinase 9 (MMP-9), modulating its expression, could play a role in susceptibility to multiple sclerosis (MS). MMP-9 PM was determined in 95 patients with MS (MS Group) and 95 age- and sex-matched controls (Control Group). Comparison of allelic frequencies showed that a higher number of CA repeats characterized the MS group (P<0.0001) and prevalence of carriers of > or =22 CA repeats was higher in the MS than in the Control Group (OR 3.4, 95% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33+/-10 vs. 28+/-10, P=0.027). No differences were found in the main MRI parameters.
Fiotti
Nicola
N
Department of Clinical, Morphological and Technological Sciences, University of Trieste, Strada di Fiume, 447, 34149, Cattinara Trieste, Italy. fiotti@units.it
Zivadinov
Robert
R
Altamura
Nicola
N
Nasuelli
Davide
D
Bratina
Alessio
A
Tommasi
Maria Antonietta
MA
Bosco
Antonio
A
Locatelli
Laura
L
Grop
Attilio
A
Cazzato
Giuseppe
G
Guarnieri
Gianfranco
G
Giansante
Carlo
C
Zorzon
Marino
M
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D018895:Microsatellite Repeats; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic; D011859:Radiography; D012307:Risk Factors
D005819:Genetic Markers; D020780:Matrix Metalloproteinase 9