title: Apolipoprotein B gene polymorphism and plasma lipid levels in phenylketonuric children.
abstract: The associations of apolipoprotein B (apoB) gene polymorphisms with blood lipid levels, also accounting for apo E polymorphisms, were assessed in 82 phenylketonuric (PKU) children on diet (34 girls, 48 boys, age 4-12 years, median 8 years). Dietary and plasma biochemical assessments were performed at six-month intervals from the age of 24 months onwards. Apo B (XbaI, MspI, EcoRI restriction sites) and apo E (E2, E3, E4) gene polymorphisms were determined by restriction-enzyme analysis after DNA extraction from blood. Subgroups of apoB polymorphisms were similar for energy intake, dietary lipids and distribution of apo E polymorphisms. Children carrying XbaI X+ / X+ showed higher plasma levels of LDL cholesterol than children carrying X- / X-/+. This gene-related response to dietary habits might play a role also in non-PKU individuals fed low-fat, low-cholesterol diets.
authors.affiliation: Department of Pediatrics, San Paolo Hospital, University of Milan, 8 Via A. di Rudini, Milan I-20142 Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Verduci
authors.forename: Carlo
authors.initials: C
authors.lastname: Agostoni
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Biondi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Radaelli
authors.forename: Marcello
authors.initials: M
authors.lastname: Giovannini
authors.forename: Enrica
authors.initials: E
authors.lastname: Riva
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010661:Phenylketonurias / Q000097:blood*; D011110:Polymorphism, Genetic
chemical_list: D001055:Apolipoproteins B; D001057:Apolipoproteins E; D008055:Lipids