[Chronobiological aspects of the action of diaminodiphenylsulfone on hematological mice induces in summer and winter seasons ].
Mice experiments were made to study effects of diaminodiphenylsulphone (DDS)--basic antileprous drug--on circadian rhythms of hemoglobin levels, counts of red cells and leukocytes. The time of the drug administration varied within the day while seasons of the year were two--winter and summer. Blood components were studied with unified methods. The results of the study showed that DDS has significant effects on the structure of circadian rhythms of the above blood components. These effects correlate with the season of the year and time of DDS administration.
Luzhnova
S A
SA
Urliapova
N G
NG
D000818:Animals; D001769:Blood / Q000187:drug effects*; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm / Q000187:drug effects; D003622:Dapsone / Q000008:administration & dosage / Q000494:pharmacology*; D004906:Erythrocyte Count; D005260:Female; D006454:Hemoglobins / Q000187:drug effects; D007917:Leprostatic Agents / Q000494:pharmacology*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012621:Seasons
D006454:Hemoglobins; D007917:Leprostatic Agents; D003622:Dapsone