title: Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats.
abstract: OBJECTIVE
  To study the effects of Radix Puerariae flavones (RPF) on liver lipid metabolism in ovariectomized (OVX) rats.
  
  
  METHODS
  Forty adult female Wistar rats were randomly divided into four groups: OVX group; sham-OVX group; OVX+estrogen group and OVX+RPF group. One week after operation rats of the first two groups were treated with physiological saline, rats of OVX+estrogen group with estrogen (1 mg/kg.b.w.) and rats of OVX+RPF group with RPF (100 mg/kg.b.w.), respectively for 5 weeks. After the rats were killed, their body weight, the weight of the abdominal fat and uterus were measured, and the levels of total cholesterol (TC) and triglyceride (TG) in liver homogenate were determined.
  
  
  RESULTS
  Compared with the sham-OVX group, the body mass of the rats in OVX group was found increased significantly; more abdominal fat in store; TC and TG in liver increased and uterine became further atrophy. As a result, the RPF was found to have an inhibitive action on those changes of various degrees.
  
  
  CONCLUSIONS
  RPF has estrogen-like effect on lipid metabolism in liver and adipose tissue.
authors.affiliation: Department of Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Guo
authors.forename: Jan-Zhao
authors.initials: JZ
authors.lastname: Niu
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Ling-Qiao
authors.initials: LQ
authors.lastname: Wang
authors.forename: Pei-Heng
authors.initials: PH
authors.lastname: Li
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D028321:Plant Preparations / Q000494:pharmacology*; D017698:Postmenopause; D029908:Pueraria; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D004967:Estrogens; D005419:Flavonoids; D028321:Plant Preparations