Disposition of uric acid upon administration of ofloxacin alone and in combination with other anti-tuberculosis drugs.
Disposition of uric acid upon administration of ofloxacin (O) alone and in combination with other anti-tuberculosis drugs, rifampicin (R), isoniazid (H) and pyrazinamide (Z) was studied. Twelve male healthy volunteers were investigated on four different occasions with the four drugs alone or in combinations. A partially balanced incomplete block design was adopted and the subjects were randomly allocated to each group. Uric acid concentration in urine samples excreted over 0-8 hr, were determined after coding the samples. There was significant decrease in the group receiving Z when compared to other groups. Though there was a decrease in uric acid excretion in the group receiving O, it was not statistically significant. Rifampicin and H seem to increase the uric acid excretion. The incidence of arthralgia was mainly due to Z and not due to either O or other drugs in the treatment of pulmonary tuberculosis.
Kumar
A K Hemanth
AK
Tuberculosis Research Centre (ICMR), Chennai 600 031, India. icmrtrc@vsnl.com
Gurumurthy
Prema
P
D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002986:Clinical Trials as Topic; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D015242:Ofloxacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011718:Pyrazinamide / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D014527:Uric Acid / Q000652:urine*
D000995:Antitubercular Agents; D014527:Uric Acid; D011718:Pyrazinamide; D015242:Ofloxacin; D007538:Isoniazid; D012293:Rifampin