title: Regeneration of uterine horn using porcine small intestinal submucosa grafts in rabbits.
abstract: Tubal factor infertility may be reversed using porcine small-intestinal submucosa (SIS). The method uses as a model the New Zealand White rabbit uerine horn. In surgery, SIS grafts were prepared from porcine jejunum; the uterine horn segment was resected and a graft was placed; then the contralateral adnexa was resected. Fecundability was tested with natural mating. Three out of six rabbits became pregnant. Gross and microscopic examination confirmed regeneration of all tissue layers. Thus, this study determined that SIS facilitates successful regeneration of uterine horn morphology in a manner similar to that observed in other tissues and species.
authors.affiliation: Department of Biomedical Sciences, Division of Physiology, Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Jon W
authors.initials: JW
authors.lastname: Taveau
authors.forename: Michele
authors.initials: M
authors.lastname: Tartaglia
authors.forename: Dana
authors.initials: D
authors.lastname: Buchannan
authors.forename: Bret
authors.initials: B
authors.lastname: Smith
authors.forename: George
authors.initials: G
authors.lastname: Koenig
authors.forename: Kevin
authors.initials: K
authors.lastname: Thomfohrde
authors.forename: Bruce
authors.initials: B
authors.lastname: Stouch
authors.forename: Saul
authors.initials: S
authors.lastname: Jeck
authors.forename: Charlotte H
authors.initials: CH
authors.lastname: Greene
mesh_terms: D000818:Animals; D005187:Fallopian Tubes / Q000502:physiology* / Q000601:surgery* / Q000648:ultrastructure; D005260:Female; D005298:Fertility; D007413:Intestinal Mucosa / Q000637:transplantation*; D007583:Jejunum / Q000637:transplantation*; D008855:Microscopy, Electron, Scanning; D011247:Pregnancy; D011817:Rabbits; D012038:Regeneration; D013552:Swine; D014183:Transplantation, Heterologous