title: CT colonography: feasibility of substantial dose reduction--comparison of medium to very low doses in identical patients.
abstract: In a feasibility study, the authors compared polyp detection and interobserver variability at computed tomographic (CT) colonography in 15 patients with doses ranging from medium to very low (12.00-0.05 mSv). At levels down to 2% of the medium dose, the mean detection of polyps 5 mm or larger remained at least 74%, while the number of false-positive results decreased and the interobserver agreement remained constant. Initial observations indicate that it is feasible to reduce the radiation dose required for CT colonography. Further studies are needed, however, to investigate the clinical value of very low-dose CT colonography.
authors.affiliation: Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. r.e.vangelder@amc.uva.nl
authors.forename: Rogier E
authors.initials: RE
authors.lastname: van Gelder
authors.forename: Henk W
authors.initials: HW
authors.lastname: Venema
authors.forename: Jasper
authors.initials: J
authors.lastname: Florie
authors.forename: C Yung
authors.initials: CY
authors.lastname: Nio
authors.forename: Iwo W O
authors.initials: IW
authors.lastname: Serlie
authors.forename: Michiel P
authors.initials: MP
authors.lastname: Schutter
authors.forename: Jeroen C
authors.initials: JC
authors.lastname: van Rijn
authors.forename: Frans M
authors.initials: FM
authors.lastname: Vos
authors.forename: Afina S
authors.initials: AS
authors.lastname: Glas
authors.forename: Patrick M M
authors.initials: PM
authors.lastname: Bossuyt
authors.forename: Joep F W
authors.initials: JF
authors.lastname: Bartelsman
authors.forename: Johan S
authors.initials: JS
authors.lastname: Laméris
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
mesh_terms: D000328:Adult; D000368:Aged; D016477:Artifacts; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005189:False Positive Reactions; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011874:Radiometry / Q000706:statistics & numerical data*; D012307:Risk Factors; D012680:Sensitivity and Specificity