title: Pilot study of dermal and subcutaneous fat structures by MRI in individuals who differ in gender, BMI, and cellulite grading.
abstract: OBJECTIVE
  Puckered, dimply skin on the thighs, hips, and buttocks is known as cellulite. The cause of cellulite is not known, although there are a number of different hypotheses. In this study, we use magnetic resonance (MR) micro-imaging to study cellulite skin. To the best of our knowledge, this is the first reported MR study of cellulite.
  
  
  METHODS
  High-resolution in vivo MR images of the postlateral thigh skin of two male groups and four female groups were obtained. Subjects were grouped according to their body mass index (BMI) and cellulite grade. A qualitative assessment of how MRI can be used to differentiate skin tissue at different levels of cellulite grading was performed.
  
  
  RESULTS
  We found that changes in skin architecture with cellulite can be visualized by in vivo MR micro-imaging. The skin fat layers beneath the dermis and down to the level of muscles are well visualized in the images. Also, the diffuse pattern of extrusion of underlying adipose tissue into dermis is clearly imaged, and was found to correlate with cellulite grading. We also show that other skin tissue parameters such as (a) the percentile of adipose vs. connective tissue in a given volume of hypodermis and (b) the percentile of hypodermic invaginations inside the dermis are correlated with cellulite grade.
  
  
  CONCLUSIONS
  MR images can be interpreted to measure tissue parameters correlated with cellulite. Considering that we had only three subjects in each group, the achievements of this pilot study were highly satisfactory. We have shown that the in vivo micro-MR is a technique able to detect the effects of cellulite and gender. This study can be extended for further investigations of drugs and/or medical devices for cellulite treatment.
authors.affiliation: Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Canada. fmirrashed@ottawahospital.on.ca
authors.forename: F
authors.initials: F
authors.lastname: Mirrashed
authors.forename: J C
authors.initials: JC
authors.lastname: Sharp
authors.forename: V
authors.initials: V
authors.lastname: Krause
authors.forename: J
authors.initials: J
authors.lastname: Morgan
authors.forename: B
authors.initials: B
authors.lastname: Tomanek
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D015992:Body Mass Index; D003238:Connective Tissue / Q000033:anatomy & histology; D020405:Dermis / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012867:Skin / Q000033:anatomy & histology*; D040521:Subcutaneous Tissue / Q000033:anatomy & histology*