8302A/C and (TTA)n polymorphisms in the HMG-CoA reductase gene may be associated with some plasma lipid metabolic phenotypes in patients with coronary heart disease.
HMG-CoA reductase (HMGCR) is a rate-limiting enzyme that participates in cholesterol metabolism. Here we analyzed the 8302A/C and the (TTA)n polymorphisms in the HMGCR gene in 169 Chinese patients with coronary heart disease (CHD) and 161 age-matched controls. Results indicated that the levels of plasma VLDL and TG in patients with the AA genotype of the 8302A/C locus were significantly higher than in patients with other genotypes (P < 0.05). In addition, the frequency of allele A4 of the (TTA)n locus was higher (P < 0.05) and the frequency of allele A5 was lower (P = 0.002) in CHD patients than in the controls. This suggests that both polymorphisms in the HMGCR gene may be associated with lipid and lipoprotein abnormalities in CHD in the Chinese.
Tong
Yu
Y
Department of Medical Genetics, West China Hospital, Chengdu 610041, China.
Zhang
Sizhong
S
Li
Hai
H
Su
Zhiguang
Z
Kong
Xiangdong
X
Liu
Hekun
H
Xiao
Cuiying
C
Sun
Yan
Y
Shi
Jia Jun
JJ
D044466:Asian People / Q000235:genetics; D015243:Cholesterol, VLDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood*; D018911:Trinucleotide Repeats / Q000235:genetics
D015243:Cholesterol, VLDL; D014280:Triglycerides; D006903:Hydroxymethylglutaryl CoA Reductases