title: [Nicergoline-induced Prinzmetal angina. "Heartache" instead of headache].
abstract: A 56 year old woman was admitted to our hospital with crescendo chest pain in the last ten days. Her past history included hypertension treated by 100 mg metoprolol for more than ten years and right carotid endarterectomy. She complained headache and a treatment of 20 mg nicergoline (ergoline derivate) daily was started. Her chest pains started always one hour after the nicergoline intake. The chest pain was accompanied by breathing difficulties and sweating of 5 min duration at first but the next days it lasted longer and longer. Next morning following her admission, one hour after the nicergoline administration she had severe chest pain again. The ECG showed ST-segment elevation in inferior leads resolved after nitroglycerin administration. The angiogram revealed normal coronary artery. Nicergoline was stopped. The patient was treated with felodipine and remains free of symptoms. Nicergoline was good for head but worse for heart in this case.
authors.affiliation: Budai Irgalmasrendi Kórház, Kardiológia. tomcsanyi.janos@axelero.hu
authors.forename: János
authors.initials: J
authors.lastname: Tomcsányi
authors.forename: Tibor
authors.initials: T
authors.lastname: Vecsey
authors.forename: Tihamér
authors.initials: T
authors.lastname: Tátrai
mesh_terms: D000788:Angina Pectoris, Variant / Q000139:chemically induced* / Q000150:complications; D004417:Dyspnea / Q000209:etiology; D015736:Felodipine / Q000008:administration & dosage; D005260:Female; D006261:Headache / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009530:Nicergoline / Q000008:administration & dosage / Q000009:adverse effects*; D018697:Nootropic Agents / Q000009:adverse effects; D013546:Sweating; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018697:Nootropic Agents; D014665:Vasodilator Agents; D009530:Nicergoline; D015736:Felodipine