Displacements of prohead protease genes in the late operons of double-stranded-DNA bacteriophages.
Most of the known prohead maturation proteases in double-stranded-DNA bacteriophages are shown, by computational methods, to fall into two evolutionarily independent clans of serine proteases, herpesvirus assemblin-like and ClpP-like. Phylogenetic analysis suggests that these two types of phage prohead protease genes displaced each other multiple times while preserving their exact location within the late operons of the phage genomes.
Liu
Jing
J
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA. jil@stowers-institute.org
Mushegian
Arcady
A
D000595:Amino Acid Sequence; D004267:DNA Viruses / Q000201:enzymology / Q000235:genetics*; D010450:Endopeptidases / Q000235:genetics*; D016679:Genome, Viral; D008969:Molecular Sequence Data; D009876:Operon; D010802:Phylogeny; D014758:Viral Core Proteins / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics
D014758:Viral Core Proteins; D014764:Viral Proteins; C079287:scaffold protein, Herpes simplex virus-1; D010450:Endopeptidases; C075881:prohead protease, bacteriophage T4