FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. I. Taxonomy, fermentation, isolation, physico-chemical properties.
FR171456 and FR173945, novel and potent cholesterol synthesis inhibitors, have been isolated from the fermentation broth of a fungal strain No. 15604. This strain was identified Sporormiella minima from its mycological characteristics. FR171456 and FR173945 strongly inhibited cholesterol synthesis in human hepatoma cell line Hep G2. These compounds also have in vitro antifungal activity against Candida albicans and Aspergillus fumigatus.
Hatori
Hidetaka
H
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. hidetaka_hatori@po.fujisawa.co.jp
Shibata
Toshihiro
T
Tsurumi
Yasuhisa
Y
Nakanishi
Tomoko
T
Katsuoka
Masaaki
M
Ohtsu
Yoshihiro
Y
Sakamoto
Kazutoshi
K
Takase
Shigehiro
S
Ueda
Hirotsugu
H
Hino
Motohiro
M
Fujii
Takashi
T
D000924:Anticholesteremic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry / Q000378:metabolism*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D008970:Molecular Weight; D019906:Nuclear Magnetic Resonance, Biomolecular; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000924:Anticholesteremic Agents; C487953:FR171456; D002784:Cholesterol