title: Immunoglobulin M-enriched intravenous polyclonal immunoglobulins reduce bacteremia following Klebsiella pneumoniae infection in an acute respiratory distress syndrome rat model.
abstract: Mechanical ventilation is known to induce bacterial translocation from the lung into the systemic circulation. This study determined the effect of immunoglobulin M (IgM)-enriched polyclonal immunoglobulins on bacteremia due to ventilation-induced translocation in an acute respiratory distress syndrome (ARDS) rat model with Klebsiella-induced pneumonia. After whole lung lavage, Sprague-Dawley rats intravenously received either a high dose or a low dose of an immunoglobulin preparation, or an albumin solution as control, followed by an intratracheal injection of a Klebsiella pneumoniae solution. Blood colony-forming units (CFUs) in the treatment groups were significantly lower during the 3-hour ventilation period compared to the control group. The authors conclude that IgM-enriched polyclonal immunoglobulins lead to a reduction of bacteria in blood of surfactant-deficient, ventilated rats infected with Klebsiella pneumoniae.
authors.affiliation: Department of Anesthesiology, Erasmus MC-Faculty, Rotterdam, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: Lachmann
authors.forename: A H L C
authors.initials: AH
authors.lastname: van Kaam
authors.forename: J J
authors.initials: JJ
authors.lastname: Haitsma
authors.forename: S J C
authors.initials: SJ
authors.lastname: Verbrugge
authors.forename: F
authors.initials: F
authors.lastname: Delreu
authors.forename: B
authors.initials: B
authors.lastname: Lachmann
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D001784:Blood Gas Analysis; D001794:Blood Pressure; D018893:Bronchoalveolar Lavage; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D007106:Immune Sera / Q000008:administration & dosage / Q000276:immunology; D007116:Immunization, Passive; D007075:Immunoglobulin M / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D007710:Klebsiella Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D007711:Klebsiella pneumoniae / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000150:complications*
chemical_list: D000907:Antibodies, Bacterial; D007106:Immune Sera; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous