title: Successful treatment of pyoderma gangrenosum with topical 0.5% nicotine cream.
abstract: Pyoderma gangrenosum is potentially a devastating and destructive disorder. There is no uniformly effective or specific therapy for pyoderma gangrenosum. Previous reports of nicotine therapy for pyoderma gangrenosum have suggested it to be efficacious. Unfortunately, previous reports were restricted by the use of commercially available preparations of nicotine, either as a gum or patch formulation. We have used topical nicotine 0.5% w/w cetamacrogol formula A cream that enables direct application onto the lesion, as well as dose and concentration variation. Two patients with pyoderma gangrenosum treated with topical nicotine 0.5% w/w cetamacrogol formula A cream are described here, both of whom had dramatic clinical resolution of their pyoderma gangrenosum.
authors.affiliation: Department of Dermatology, University Hospital of Wales, Heath Park, Cardiff, UK. patelgk@cf.ac.uk
authors.forename: G K
authors.initials: GK
authors.lastname: Patel
authors.forename: J R
authors.initials: JR
authors.lastname: Rhodes
authors.forename: B
authors.initials: B
authors.lastname: Evans
authors.forename: P J A
authors.initials: PJ
authors.lastname: Holt
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D001132:Arm; D003424:Crohn Disease; D003922:Diabetes Mellitus, Type 1; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage*; D007866:Leg; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage*; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000473:pathology
chemical_list: D007641:Keratolytic Agents; D009538:Nicotine