title: Flumazenil--treatment or toxin.
abstract: Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined in each overdose patient. Indications for flumazenil are limited.
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA. donna.seger@vanderbilt.edu
authors.forename: Donna L
authors.initials: DL
authors.lastname: Seger
mesh_terms: D000931:Antidotes / Q000627:therapeutic use* / Q000633:toxicity*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004636:Emergency Service, Hospital; D005442:Flumazenil / Q000627:therapeutic use* / Q000633:toxicity*; D006801:Humans; D011041:Poisoning / Q000188:drug therapy* / Q000209:etiology* / Q000401:mortality; D018570:Risk Assessment; D012640:Seizures / Q000139:chemically induced; D015996:Survival Rate
chemical_list: D000931:Antidotes; D005442:Flumazenil