Dilated cardiomyopathy in a pregnant woman after doxorubicin and radiotherapy for Hodgkin's disease: a case report.
BACKGROUND
Hodgkin's disease occurs frequently in women of reproductive age. Anthracyclines in general and doxorubicin in particular are integral parts of therapy.


METHODS
A 24-year-old primigravida had dilated cardiomyopathy diagnosed at 34 weeks'gestation. Three years earlier she had been treated with chest radiation and combination chemotherapy, including doxorubicin, for Hodgkin's disease.


CONCLUSIONS
The clinician should be aware of this manifestation. Multidisciplinary supervision throughout pregnancy as well as planned timing and mode of delivery are mandatory.
Hadar
Amnon
A
Department of Obstetrics and Gynecology A , Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel. hadaram@bgumail.bgu.ac.il
Sheiner
Eyal
E
Press
Fernanda
F
Katz
Amos
A
Katz
Miriam
M
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced*; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000532:radiotherapy
D000903:Antibiotics, Antineoplastic; D004317:Doxorubicin