title: Expression Profiler: next generation--an online platform for analysis of microarray data.
abstract: Expression Profiler (EP, http://www.ebi.ac.uk/expressionprofiler) is a web-based platform for microarray gene expression and other functional genomics-related data analysis. The new architecture, Expression Profiler: next generation (EP:NG), modularizes the original design and allows individual analysis-task-related components to be developed by different groups and yet still seamlessly to work together and share the same user interface look and feel. Data analysis components for gene expression data preprocessing, missing value imputation, filtering, clustering methods, visualization, significant gene finding, between group analysis and other statistical components are available from the EBI (European Bioinformatics Institute) web site. The web-based design of Expression Profiler supports data sharing and collaborative analysis in a secure environment. Developed tools are integrated with the microarray gene expression database ArrayExpress and form the exploratory analytical front-end to those data. EP:NG is an open-source project, encouraging broad distribution and further extensions from the scientific community.
authors.affiliation: European Bioinformatics Institute, United Kingdom.
authors.forename: Misha
authors.initials: M
authors.lastname: Kapushesky
authors.forename: Patrick
authors.initials: P
authors.lastname: Kemmeren
authors.forename: Aedín C
authors.initials: AC
authors.lastname: Culhane
authors.forename: Steffen
authors.initials: S
authors.lastname: Durinck
authors.forename: Jan
authors.initials: J
authors.lastname: Ihmels
authors.forename: Christine
authors.initials: C
authors.lastname: Körner
authors.forename: Meelis
authors.initials: M
authors.lastname: Kull
authors.forename: Aurora
authors.initials: A
authors.lastname: Torrente
authors.forename: Ugis
authors.initials: U
authors.lastname: Sarkans
authors.forename: Jaak
authors.initials: J
authors.lastname: Vilo
authors.forename: Alvis
authors.initials: A
authors.lastname: Brazma
mesh_terms: D020869:Gene Expression Profiling; D023281:Genomics; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software; D014584:User-Computer Interface