Relationship between ACE-DD polymorphism and diastolic performance in healthy subjects.
BACKGROUND
The ACE-D allele has been associated with cardiovascular disease. The study evaluates the relationship between the ACE-ID genotypes and diastolic function in healthy subjects after 6 years of follow-up.


METHODS
Two hundred and seventy-five healthy volunteers aged 25-55 years had normal physical examination, 12-lead ECG, acceptable echocardiographic windows and echocardiogram at entry. Venous blood was drawn for DNA analysis.


RESULTS
Two hundred and forty-two subjects completed 6 years of follow-up. Three genetically distinct groups were obtained: ACE-DD group (n=71, 26F/45M, mean age 48 +/- 7 years); ACE-ID (n=115, 39F/76M, mean age 40 +/- 7 years); and ACE-II (n=56, 20F/36M, mean age 47 +/- 6 years). Significant differences in E/A ratio were found between ACE-DD and ACE-ID, and ACE II (p=0.028, <0.0001, 0.0001), respectively. After 6 years, echocardiography showed a significant reduction of E/A ratio in the ACE-DD group, p=0.0001.


CONCLUSIONS
The data suggest that ACE-DD is associated with deteriorating myocardial diastolic properties.
Di Pasquale
Pietro
P
Division of Cardiology Paolo Borsellino, G.F. Ingrassia Hospital, Via Val Platani 3, IT-90144 Palermo, Italy. LEHDi@tin.it
Cannizzaro
Sergio
S
Scalzo
Sebastiano
S
Giubilato
Alfonso
A
Maringhini
Giorgio
G
Giambanco
Francesco
F
Sarullo
Filippo
F
Tarsia
Giandomenico
G
Giammanco
Marco
M
Gaspare
Parrinello
P
Paterna
Salvatore
S
D000328:Adult; D000367:Age Factors; D000483:Alleles; D000704:Analysis of Variance; D015331:Cohort Studies; D003971:Diastole / Q000235:genetics* / Q000502:physiology; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006439:Hemodynamics / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012737:Sex Factors; D013997:Time Factors; D044465:White People / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A