Iron supplementation in experimental hyperthyroidism: effects on oxidative stress in skeletal muscle tissue.
This study was designed to investigate the effects of iron supplementation on the parameters of oxidative stress in the skeletal muscle tissue of hyperthyroidism induced rats. Hyperthyroidism was found to cause an increase in thiobarbituric acid-reactive substances (TBARS) and copper zinc superoxide dismutase (Cu, Zn SOD) activity, but decreases in the glutathione-peroxidase (GSH Px) activity and glutathione (GSH). Iron supplementation caused an increase in TBARS and a decrease in GSH. Iron supplementation in hyperthyroid rats attenuated the hyperthyroid state, but lowered the plasma ferritin level, which is considered an indicator of thyroid hormone action. Iron supplementation caused no additional increase in the TBARS in hyperthyroid rats, ameliorated the decrease in GSH content and abolished the induction of Cu, Zn SOD. Our findings suggested no increase, but a decrease, in the risk of oxidative stress in iron supplemented hyperthyroid rats. Whether supplementation of iron would have similar effects in humans should be further investigated in clinical studies.
Seymen
Hakki Oktay
HO
Barbaros mah. Sedef Sok. Onur Sitesi, 9/23 Uskudar, Istanbul, Turkey 81150. seymano@yahoo.com
Civelek
Sabiha
S
Seven
Arzu
A
Yigit
Gunnur
G
Hatemi
Husrev
H
Burcak
Gulden
G
D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D006980:Hyperthyroidism / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014284:Triiodothyronine / Q000097:blood
D017392:Thiobarbituric Acid Reactive Substances; D014284:Triiodothyronine; D007501:Iron; D013482:Superoxide Dismutase; D005978:Glutathione