alpha-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats.
alpha-Lipoic acid treatment (100 mg/kg/day for 2 weeks after 6 weeks of untreated diabetes) of streptozotocin diabetic rats partially but significantly reversed both reduced contractile response of distal colon to acetylcholine and delayed transit of charcoal meal in small intestine compared to diabetic control. These effects of alpha-Lipoic acid were associated with complete reversal of diabetes induced increased plasma lipid peroxidation level. alpha-Lipoic acid had no effect on any of the parameters measured in non-diabetic rats. These findings demonstrate contribution of oxidative stress in the development of physiological changes of gut in diabetes.
Kumar
M Satish
MS
Department of Studies in Biochemistry, University of Mysore, Manasagangotri, Mysore 570 006, India. mskgowda@yahoo.com
Prashanth
K V Harish
KV
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight; D003106:Colon / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental; D005260:Female; D007421:Intestine, Small / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D008063:Thioctic Acid / Q000494:pharmacology*
D000975:Antioxidants; D013311:Streptozocin; D008063:Thioctic Acid; D000109:Acetylcholine