[Effect of lycopene on DNA oxidative damage of cells in rats].
OBJECTIVE
Observe the protective effect of Lycopene(LP) on DNA damage.


METHODS
Rats were given LP after 4 weeks, the DNA break in peripheral blood lymphocytes and liver cells from the rats were analyzed with single cell gel electrophoresis.


RESULTS
Compared with control, the damage of DNA in LP group were reduced significantly(P < 0.05).


CONCLUSIONS
LP could protect DNA damage of peripheral blood lymphocytes and liver cells in rats.
Pan
Hongzhi
H
Public Health School of Harbin Medical University, Harbin 150001, China.
Na
Lixin
L
Shi
Gang
G
Li
Xingsan
X
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002338:Carotenoids / Q000494:pharmacology*; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D022781:Hepatocytes / Q000648:ultrastructure; D000077276:Lycopene; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D002338:Carotenoids; D000077276:Lycopene