Recovery of forward stepping in spinal cord injured patients does not transfer to untrained backward stepping.
Six spinal cord injured (SCI) patients were trained to step on a treadmill with body-weight support for 1.5-3 months. At the end of training, foot motion recovered the shape and the step-by-step reproducibility that characterize normal gait. They were then asked to step backward on the treadmill belt that moved in the opposite direction relative to standard forward training. In contrast to healthy subjects, who can immediately reverse the direction of walking by time-reversing the kinematic waveforms, patients were unable to step backward. Similarly patients were unable to perform another untrained locomotor task, namely stepping in place on the idle treadmill. Two patients who were trained to step backward for 2-3 weeks were able to develop control of foot motion appropriate for this task. The results show that locomotor improvement does not transfer to untrained tasks, thus supporting the idea of task-dependent plasticity in human locomotor networks.
Grasso
Renato
R
IRCCS Fondazione Santa Lucia, via Ardeatina 306, 00179, Rome, Italy.
Ivanenko
Yuri P
YP
Zago
Myrka
M
Molinari
Marco
M
Scivoletto
Giorgio
G
Lacquaniti
Francesco
F
D000293:Adolescent; D000328:Adult; D001696:Biomechanical Phenomena; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods; D005260:Female; D020233:Gait Disorders, Neurologic / Q000503:physiopathology* / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000503:physiopathology* / Q000534:rehabilitation; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D009473:Neuronal Plasticity / Q000502:physiology; D010243:Paralysis / Q000503:physiopathology* / Q000534:rehabilitation; D010809:Physical Fitness / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000534:rehabilitation; D016896:Treatment Outcome