[Method of continuous intravenous postoperative analgesia with promedol in newborn children].
Continuous intravenous infusion of promedol, 0.1 mg/kg, with additional boluses, 0.5 mg/kg, was used as postoperative analgesia in 20 newborns. Fifteen (25%) children were operated for congenital gastrointestinal defects or peritonitis, 2 children (10%)--for chylothorax, and tumor was eradicated in 3 (15%) children. On the basis of behavioral reactions, physiological indices (cardiac rate, arterial pressure, SpO2, and respiration rate/artificial pulmonary ventilation--APL) as well as of laboratory "stress" tests (blood glucose and cortisol and acid-base balance) it was proven that analgesia with continuous intravenous promedol infusion was effective. It was shown as possible to administer the promedol infusion in newborns while switching them from APL to independent breathing until the spontaneous breathing with constant positive pressure is ensured provided the pO2, pCO2 and SpO2 respiration indices are satisfactory.
Zhirkova
Iu V
IuV
Stepanenko
S M
SM
Butyleva
O Iu
OIu
Zilbert
E V
EV
Manerova
A F
AF
Golodenko
N V
NV
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D018730:Infant Behavior / Q000187:drug effects / Q000502:physiology; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008991:Monitoring, Physiologic; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D011182:Postoperative Care / Q000379:methods*; D011396:Promedol / Q000008:administration & dosage / Q000627:therapeutic use*; D012121:Respiration, Artificial
D000701:Analgesics, Opioid; D011396:Promedol