title: Two cases of congenital nephrotic syndrome.
abstract: The clinical course and renal histological changes in two patients with congenital nephrotic syndrome are presented. Both patients developed edema and proteinuria at 2 days of age. Steroids and immunosuppressive drugs were not used in either patient. One patient showed gradual disappearance of nephrotic syndrome and proteinuria during the 16-month follow-up. In the other patient, the nephrotic state persisted and nephrotic complications necessitated bilateral nephrectomy when she was 12 months old. Renal biopsy showed minimal change lesions in one patient, while the nephrectomized kidneys showed mild mesangial proliferation and matrix increase in the glomeruli. No tubular dilatation or microcysts were observed in either patient.
authors.affiliation: Department of Pediatrics, Yamato City Hospital, 8-3-6 Fukaminishi, Yamato, Kanagawa 242-8602, Japan. kikuo.iitaka@gov.city.yamato.kanagawa.jp
authors.forename: Kikuo
authors.initials: K
authors.lastname: Iitaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Motoyama
authors.forename: Midori
authors.initials: M
authors.lastname: Hojo
authors.forename: Naomi
authors.initials: N
authors.lastname: Iwanami
authors.forename: Hiroe
authors.initials: H
authors.lastname: Koshino
authors.forename: Shinya
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Moriya
mesh_terms: D001706:Biopsy; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009392:Nephrectomy; D009402:Nephrosis, Lipoid / Q000151:congenital / Q000473:pathology / Q000601:surgery; D009404:Nephrotic Syndrome / Q000151:congenital / Q000473:pathology* / Q000601:surgery; D011507:Proteinuria / Q000151:congenital / Q000473:pathology* / Q000601:surgery; D012075:Remission, Spontaneous