title: Leptomeningeal precursor B-cell lymphoblastic lymphoma in a child with minimal bone marrow involvement.
abstract: The authors report an unusual presentation of a leptomeningeal lymphoblastic lymphoma in a 6-year-old boy with headache and papilledema as the only initial manifestations. The diagnosis was confirmed by the presence of precursor B-cell lymphoblasts in the cerebrospinal fluid, with no cerebral mass and with only 9% phenotypically identical blasts in the bone marrow. This patient was treated on a high-risk ALL protocol with intensive systemic/intrathecal chemotherapy plus cranial irradiation, and he remained in complete remission 6 months after his initial diagnosis.
authors.affiliation: University of Toronto, Division of Hematology/Oncology, The Hospital for Sick Children, ON, Canada. oussama.abla@sickkids.ca
authors.forename: Oussama
authors.initials: O
authors.lastname: Abla
authors.forename: Ahmed
authors.initials: A
authors.lastname: Naqvi
authors.forename: Charles
authors.initials: C
authors.lastname: Ye
authors.forename: Rakesh
authors.initials: R
authors.lastname: Bhattacharjee
authors.forename: Mary
authors.initials: M
authors.lastname: Shago
authors.forename: Mohamed
authors.initials: M
authors.lastname: Abdelhaleem
authors.forename: Sheila
authors.initials: S
authors.lastname: Weitzman
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D002648:Child; D002869:Chromosome Aberrations; D006261:Headache / Q000209:etiology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D017254:Leukemic Infiltration / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008578:Meninges / Q000473:pathology*; D023461:Myeloid Progenitor Cells / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology