MACROSCOPIC, MICROSCOPIC, AND MECHANICAL ANALYSES OF PROTOTYPE DOUBLE VELOUR VASCULAR GRAFTS.
In-vivo and ex-vivo evaluations of two prototype double velour tube grafts have been conducted. The experimental grafts were fabricated from terry cloth derivatives of the Dacron polyester material that is used in the construction of presently available Microvel(R) Double Velour and Cooley Double Velour Guideline(R) grafts.(*) The use of terry cloth derivatives in the experimental grafts provides a velour pile that is more uniform in height and density than current clinical grafts. The hypothesis examined by these studies was whether the utilization of terry cloth derivatives provides a more perfect capsular and luminal surface for fibrous tissue attachment and ingrowth, thereby enhancing neointimal formation at the blood contacting surface. Using standard techniques, prototype grafts were implanted in the abdominal aortas of dogs for test periods of 1 to 6 months. All grafts remained patent throughout the healing period. At explantation, the macroscopic and microscopic properties of the grafts were examined and characterized. Neointimal analysis demonstrated that the lighter denier, higher porosity prototype consistently produced more homogeneous blood-contacting surfaces with smoother contours and more complete endothelialization than the heavier denier, lower porosity prototype. From these analyses, we can conclude that both prototype grafts possess the basic properties of useful arterial prostheses. They are not prone to early thrombosis, and exhibit rapid healing properties. This study indicates that the use of terry cloth derivatives provides a more uniform, less random velour pile and that arterial grafts constructed from such materials produce more uniform and biologically stable neointimas.
Holub
Daniel A.
DA
Cardiovascular Surgical Research Laboratories, the Department of Surgery, and the Department of Pathology, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Houston, Texas.
Trono
Ruben
R
Klima
Tomas
T
Norman
John C.
JC