In vitro effects of organophosphate pesticides on rat erythrocytes.
In vitro effects of various organophosphate pesticides (dimethoate, chlorpyrifos, ethion and monocrotophos) were studied on hemolysis, K+ leakage and lipid peroxidation in rat erythrocytes. All the four pesticides increased hemolysis and K+ leakage from erythrocytes, that was concentration and time dependent. On the contrary, there was decrease in lipid peroxidation in erythrocyte membrane. Effect of pesticides on lipid peroxidation could be due to pesticide itself abstracting protons or interacting with free radicals rather than polyunsaturated fatty acids (PUFA), thereby protecting the latter against peroxidation.
Singh
Mohan
M
Department of Biochemistry, Panjab University, Chandigarh 160 014, India.
Sandhir
Rajat
R
Kiran
Ravi
R
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006461:Hemolysis; D007306:Insecticides / Q000494:pharmacology*; D015227:Lipid Peroxidation; D008297:Male; D009943:Organophosphorus Compounds; D010575:Pesticides / Q000737:chemistry; D011188:Potassium / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D005231:Fatty Acids, Unsaturated; D007306:Insecticides; D009943:Organophosphorus Compounds; D010575:Pesticides; D011188:Potassium