title: Hereditary gingival fibromatosis associated with generalized aggressive periodontitis: a case report.
abstract: BACKGROUND
  Hereditary gingival fibromatosis is a rare, genetically inherited overgrowth condition that is clinically characterized by a benign fibrous enlargement of maxillary and mandibular keratinized gingiva. A syndromic association between gingival fibromatosis and a wide variety of other genetically inherited disorders has been described. However, its coexistence with aggressive periodontitis has not been reported.
  
  
  METHODS
  A 24-year-old African-American female, patient (proband X, [Px]) reported with a chief complaint of tooth mobility and gingival enlargement. Clinical examination revealed moderate to severe gingival overgrowth on both mandible and maxilla. Generalized attachment loss and mobility of the teeth were observed. Radiographic evaluation demonstrated severe alveolar bone loss. The patient was diagnosed with gingival fibromatosis and aggressive periodontitis based on the clinical and radiographic findings. Her brother (Bx) and her mother (Mx) were evaluated and diagnosed with gingival fibromatosis suggesting that this is a dominant trait in the family and gingival fibromatosis might be of hereditary origin. In addition, the brother also exhibited localized aggressive periodontitis. Medical history revealed no other systemic or local contributory factors associated with the oral findings in any of the subjects.
  
  
  RESULTS
  Surgical therapy included internal bevel gingivectomy combined with open flap debridement procedures for Px and Bx. Only internal bevel gingivectomy was performed for Mx since there was mild bone resorption and no intrabony defects. At the time of surgery, gingival biopsies were obtained and fixed in 4% paraformaldehyde. Multiple serial sections were stained with hematoxylin and eosin. Microscopic evaluation of the gingival specimens revealed large parallel collagen bundles associated with scarce fibroblasts in the connective tissue. The collagen bundles reached into the subepithelial connective tissue where elongated rete-pegs were also observed. Following the completion of the treatment, no signs of recurrence or bone resorption were observed over 2-year follow-up.
  
  
  CONCLUSIONS
  This is the first report of hereditary gingival fibromatosis associated with aggressive periodontitis. Combined treatment comprising removal of fibrotic gingival tissue and traditional flap surgery for the elimination of intrabony defects represents a unique treatment approach in periodontal therapy. Two-year follow-up revealed that both the gingival overgrowth and the destructive lesions were successfully treated.
authors.affiliation: Department of Periodontology and Oral Biology, Boston University, Goldman School of Dental Medicine, Boston, MA 02118, USA.
authors.forename: Piero
authors.initials: P
authors.lastname: Casavecchia
authors.forename: M Ilhan
authors.initials: MI
authors.lastname: Uzel
authors.forename: Alpdogan
authors.initials: A
authors.lastname: Kantarci
authors.forename: Hatice
authors.initials: H
authors.lastname: Hasturk
authors.forename: Serge
authors.initials: S
authors.lastname: Dibart
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Hart
authors.forename: Philip C
authors.initials: PC
authors.lastname: Trackman
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Van Dyke
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000209:etiology; D005260:Female; D005351:Fibromatosis, Gingival / Q000235:genetics*; D005500:Follow-Up Studies; D005890:Gingivectomy; D006801:Humans; D017622:Periodontal Attachment Loss / Q000209:etiology; D010518:Periodontitis / Q000150:complications*; D013524:Surgical Flaps; D014086:Tooth Mobility / Q000209:etiology