The Notch and Sonic hedgehog signalling pathways in immunity.
There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.
Benson
Robert A
RA
Immunobiology Group, MRC Centre for Inflammation Research, College of Medicine and Veterinary Medicine, University of Edinburgh, Medical Buildings, Teviot Place, Edinburgh, EH8 9AG, UK.
Lowrey
Jacqueline A
JA
Lamb
Jonathan R
JR
Howie
Sarah E M
SE
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology; D053823:Hedgehog Proteins; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000502:physiology*; D008565:Membrane Proteins / Q000276:immunology / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology; D011014:Pneumonia / Q000276:immunology; D051880:Receptors, Notch; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology*; D015534:Trans-Activators / Q000276:immunology / Q000502:physiology*
D053823:Hedgehog Proteins; D008565:Membrane Proteins; D051880:Receptors, Notch; C509239:SHH protein, human; D015534:Trans-Activators