Weekly treatments with a burst-firing magnetic field alters behavior in the elevated plus maze after two sessions.
In a split-litter design, rats were either injected with 15 mg/kg of clomipramine or saline from postnatal Days 8 through 21. Other rats from the same litters were not injected. When the rats were 90 days of age, the rats were tested once per week for five weeks in an elevated plus maze that contained two open arms (no alls) and two walled arms. Following each test, they were exposed (total of 4 exposures) for 30 min. to a burst-firing magnetic field (1 microTesla) that has been shown to reduce depression in human beings. After two treatments, the rats exposed to the burst-firing fields spent about half the amount of time in the open arms compared to the sham-field exposed rats. The interaction between adult treatment and whether the rats had received the antidepressant before weaning was not significant statistically. These results suggest that at least two weekly sessions may be required before significant changes in behavior occur after weekly 30-min. exposures to these potentially "therapeutic" magnetic fields.
Fitzpatrick
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Laurentian University, Sudbury, ON, Canada.
Persinger
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MA
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects; D002997:Clomipramine / Q000494:pharmacology / Q000627:therapeutic use; D003213:Conditioning, Psychological; D003863:Depression / Q000188:drug therapy / Q000628:therapy*; D008280:Magnetics / Q000295:instrumentation*; D018782:Maze Learning; D051381:Rats
D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine