Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study.
OBJECTIVE
This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia.


METHODS
Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent (31)P MRS.


RESULTS
The phosphocreatine/total phosphorus and phosphocreatine/total ATP ratios in both basal ganglia were significantly lower in patients.


CONCLUSIONS
Schizophrenia patients showed features of increased metabolism in the basal ganglia consistent with impaired activity of the frontostriatal pathways.
Gangadhar
B N
BN
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, 560 029 Bangalore, India.
Jayakumar
P N
PN
Subbakrishna
D K
DK
Janakiramaiah
N
N
Keshavan
M S
MS
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001479:Basal Ganglia / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D010759:Phosphorus Isotopes; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism
D014150:Antipsychotic Agents; D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate