title: Inhibitory effect of Yunbutang on mast cell-dependent allergic reactions.
abstract: Yunbutang (YB) is an Oriental herbal prescription, which has been successfully applied for the treatment of allergic disorders, mainly atopic dermatitis in clinical medicine. However, its effect in experimental models remains unknown. Here, we report inhibitory effects of YB on mast cell-dependent immediate-type allergic reactions. YB inhibited systemic allergic reaction induced by compound 48/80. YB dose-dependently inhibited the histamine release from the mast cells activated by compound 48/80. YB also showed an inhibitory effect of anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by oral administration. Furthermore, YB inhibited tumor necrosis factor-alpha secretion from stimulated mast cells. These findings provide evidence that YB inhibits the mast cell-dependent allergic reactions.
authors.affiliation: Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Ho-Jeong
authors.initials: HJ
authors.lastname: Na
authors.forename: Phil-Dong
authors.initials: PD
authors.lastname: Moon
authors.forename: Seung-Heon
authors.initials: SH
authors.lastname: Hong
authors.forename: Jo-Young
authors.initials: JY
authors.lastname: Shin
authors.forename: Hyung-Min
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007723:Korea; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology*; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects* / Q000276:immunology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000633:toxicity
chemical_list: D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D003189:p-Methoxy-N-methylphenethylamine