title: Biochemical markers of myocardial damage after radiofrequency ablation.
abstract: BACKGROUND
  Radiofrequency catheter ablation (RFCA) may cause myocardial injury.
  
  
  OBJECTIVE
  To assess changes in myocardial enzymes levels following RFCA.
  
  
  METHODS
  Creatine kinase (CK), CK-MB, aspartate aminotransferase (GOT), alanine aminotransferase (GPT), troponin I and myoglobin levels were assessed in 53 patients (33 females, 20 males, mean age 53 years, range 23-78 years) before and 20 hours after successful RFCA (WPW type A = 13, WPW type B = 10, atrio-ventricular nodal tachycardia n = 17, atrial fibrillation or flutter n = 5, atrial tachycardia n = 2 and complex arrhythmias n = 6).
  
  
  RESULTS
  The mean number of RF applications was 10.4, cumulative energy - 22 671 J, duration of application - 468 sec, and temperature - 58 degrees C. A significant post-RFCA increase in the troponin I and myoglobin levels was found whereas the changes in CK and GOT levels were less pronounced. A significant correlation between troponin I elevation and RFCA energy, particularly in males, was documented. There was a trend towards a decrease in the GPT and CK-MB levels. Troponin I and myoglobin levels increased regardless of the site of RF energy application.
  
  
  CONCLUSIONS
  Troponin I and myoglobin are useful for the assessment of RFCA-induced myocardial injury, regardless of the site of RFCA application.
authors.affiliation: Department of Electrocardiology, Institute of Cardiology, Collegium Medicum, Jagiellonian University, Cracow, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Bednarek
authors.forename: Igor
authors.initials: I
authors.lastname: Tomala
authors.forename: Jacek
authors.initials: J
authors.lastname: Majewski
authors.forename: Jacek
authors.initials: J
authors.lastname: Szczepkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Lelakowski
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D017115:Catheter Ablation / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form; D005260:Female; D006335:Heart Injuries / Q000097:blood; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009211:Myoglobin / Q000097:blood*; D011237:Predictive Value of Tests; D013997:Time Factors; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D009211:Myoglobin; D019210:Troponin I; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form