title: Simian virus 40 infection down-regulates the expression of nitric oxide synthase in human mesothelial cells.
abstract: The cytotoxic effects of asbestos are partly mediated by the production of free radicals, including nitric oxide (NO). SV40 has been suggested to synergize with asbestos in the pathogenesis of malignant mesothelioma. Crocidolite asbestos fibers induced in human mesothelial and malignant mesothelioma cells a significant increase of NO synthase activity and expression, which was absent in SV40-infected cells. Furthermore, SV40 infection prevented the NF kappa B activation elicited by crocidolite in both mesothelial and mesothelioma cells. These data suggest that SV40, by inhibiting the synthesis of NO, could favor the survival of transformed, potentially neoplastic cells.
authors.affiliation: Department of Genetics, Biology and Biochemistry, University of Torino and Research Center on Experimental Medicine, Turin, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Aldieri
authors.forename: Sara
authors.initials: S
authors.lastname: Orecchia
authors.forename: Dario
authors.initials: D
authors.lastname: Ghigo
authors.forename: Loredana
authors.initials: L
authors.lastname: Bergandi
authors.forename: Chiara
authors.initials: C
authors.lastname: Riganti
authors.forename: Bice
authors.initials: B
authors.lastname: Fubini
authors.forename: Pier Giacomo
authors.initials: PG
authors.lastname: Betta
authors.forename: Amalia
authors.initials: A
authors.lastname: Bosia
mesh_terms: D017638:Asbestos, Crocidolite / Q000009:adverse effects; D002478:Cells, Cultured; D015536:Down-Regulation; D004847:Epithelial Cells / Q000187:drug effects / Q000201:enzymology* / Q000821:virology*; D006801:Humans; D008654:Mesothelioma / Q000201:enzymology* / Q000209:etiology / Q000821:virology; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D052247:Nitric Oxide Synthase Type II; D027601:Polyomavirus Infections / Q000201:enzymology / Q000821:virology; D013539:Simian virus 40 / Q000502:physiology*; D014412:Tumor Virus Infections / Q000201:enzymology / Q000821:virology
chemical_list: D016328:NF-kappa B; D017638:Asbestos, Crocidolite; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II