title: [Obsessive-compulsive symptoms in schizophrenia during treatment with clozapine and conventional antipsychotic drugs].
abstract: BACKGROUND
  We compare the prevalence of obsessive-compulsive symptoms in schizophrenic patients in treatment with clozapine and those who receive classic antipsychotic drugs.
  
  
  METHODS
  Outpatients with schizophrenia treated with clozapine (n = 56) or classic antipsychotic drugs (n = 54) at the Honorio Delgado-Hideyo Noguchi Specialized Institute in Mental Health (Lima-Peru), were evaluated for the presence of obsessive-compulsive symptoms by means of the Obsessive-Compulsive Disorder Module of Structured Clinical Interview for DSM-IV and Yale-Brown Obsessive-Compulsive Symptoms Checklist.
  
  
  RESULTS
  46.4 % of patients treated with clozapine presented obsessive-compulsive symptoms while this occurred in 20.4 % of those with classic antipsychotic drugs (p = 0.005). In addition, 21.4 % of patients with clozapine and 13 % of those treated with classic antipsychotics presented obsessive-compulsive disorder according to DSM-IV criteria (p = 0.31).
  
  
  CONCLUSIONS
  In schizophrenic patients, treatment with clozapine is associated with a higher rate of obsessive-compulsive symptoms than treatment with classic antipsychotic drugs.
authors.affiliation: Universidad Peruana Cayetano Heredia, Peru. galvezbuccollini@yahoo.com
authors.forename: J A
authors.initials: JA
authors.lastname: Galvez-Buccollini
authors.forename: F
authors.initials: F
authors.lastname: Fiestas
authors.forename: P
authors.initials: P
authors.lastname: Herrera
authors.forename: J M
authors.initials: JM
authors.lastname: Vega-Dienstmaier
authors.forename: B
authors.initials: B
authors.lastname: Guimas
authors.forename: G
authors.initials: G
authors.lastname: Mazzotti
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000145:classification / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology*; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology*
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine