Weight loss and calcium intake influence calcium absorption in overweight postmenopausal women.
BACKGROUND
Weight loss (WL) reduces bone mass and increases fracture risk. Mechanisms regulating calcium metabolism during WL are unclear.


OBJECTIVE
The objective was to assess the effect of 6 wk of WL at 2 different amounts of calcium intake [normal (NlCa): 1 g/d; high (HiCa): 1.8 g/d] on true fractional calcium absorption (TFCA), bone turnover, and bone-regulating hormones in overweight postmenopausal women.


METHODS
Seventy-three women (body mass index, 26.9 +/- 1.9 kg/m(2)) were recruited either to consume a moderately energy-restricted diet (WL group) or to maintain their body weight [weight-maintenance (WM) group] and were randomly assigned to either the HiCa or the NlCa group in a double-blind manner. Subjects underwent weekly diet counseling, and measurements were taken at baseline and after 6 wk.


RESULTS
Fifty-seven women completed the study and had a baseline TFCA of 24.9 +/- 7.4%. Energy restriction significantly decreased the total calcium absorbed (P < 0.05) in the WL group (n = 32) compared with the WM group (n = 25; analysis of covariance). Regression analysis showed that a greater rate of weight loss suppressed TFCA and the total calcium absorbed (P < 0.05) in the HiCa group. The women in the NlCa WL group absorbed inadequate amounts of calcium (195 +/- 49 mg/d), whereas the women in the HiCa WL group absorbed adequate amounts (348 +/- 118 mg/d). Parathyroid hormone explained 22% of the variance in calcium absorbed in the NlCa group only.


CONCLUSIONS
We suggest that WL is associated with elevated calcium requirements that, if not met, could activate the calcium-parathyroid hormone axis to absorb more calcium. Normal intakes of calcium during energy restriction result in inadequate total calcium absorption and could ultimately compromise calcium balance and bone mass.
Cifuentes
Mariana
M
Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA.
Riedt
Claudia S
CS
Brolin
Robert E
RE
Field
M Paul
MP
Sherrell
Robert M
RM
Shapses
Sue A
SA
D000368:Aged; D000704:Analysis of Variance; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004038:Diet, Reducing / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000494:pharmacology; D017698:Postmenopause / Q000378:metabolism*; D012044:Regression Analysis; D012621:Seasons; D015431:Weight Loss / Q000502:physiology*
D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D002118:Calcium