Effect of fluorogestone acetate on embryo recovery and quality in eCG-superovulated goats with premature luteal regression.
The objective of this study was to evaluate if treatment of eCG-superovulated goats with fluorogestone acetate (FGA) would increase the number and quality of embryos recovered. Goats (n = 25) were given an intravaginal sponge containing 45 mg FGA for 12 days, with 1000 IU eCG and 7.5mg of Luprostiol (a PGF(2 alpha) analog) given -48 and 0 h relative to sponge removal. Goats were mated by natural service every 12h during estrus and surgical embryo collection was done 6 days after the last mating. There were two treatment groups; those in the FGA group (n = 13) had a FGA sponge from 8h after mating to embryo collection, whereas goats in the control group (n = 12) did not receive any post-mating treatment. Premature luteal regression occurred in 61.5% (8/13) and 83.3% (10/12) of the goats in the FGA and the control groups, respectively (P > 0.05). Corpus luteum life span averaged 4 days in goats with premature luteolysis. The mean (+/- S.E.) number of transferable embryos was 5.7 +/- 1.6 in the FGA group and 0.1 +/- 0.1 in the control group (P < 0.05). Within the FGA group, the embryo recovery rate was similar in goats with premature luteal regression compared to those with normal luteal function, although non-transferable embryos were only found in goats with premature luteal regression. In conclusion, post-breeding treatment with FGA increased embryonic survival in eCG-superovulated goats, even though it did not prevent premature luteal regression.
Espinosa-Márquez
M C
MC
Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Zacatecas, Zacatecas, Mexico.
Valencia
J
J
Zarco
L
L
Escobar-Medina
F J
FJ
Colina-Flores
F
F
Arechiga-Flores
C F
CF
D000282:Administration, Intravaginal; D000818:Animals; D001947:Breeding; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D004622:Embryo, Mammalian / Q000502:physiology*; D005260:Female; D003425:Flurogestone Acetate / Q000008:administration & dosage*; D006041:Goats; D003341:Luteolysis / Q000187:drug effects*; D011247:Pregnancy; D013480:Superovulation; D013997:Time Factors; D020858:Tissue and Organ Harvesting / Q000662:veterinary*
D006063:Chorionic Gonadotropin; D003425:Flurogestone Acetate