Deep brain stimulation in Parkinson's disease.
Throughout the past decade, there has been a marked increase in surgical therapies, primarily deep brain stimulation (DBS), for the treatment of advanced Parkinson's disease (PD). DBS of the thalamus has been shown to be effective in reducing parkinsonian tremor; however, it is not the treatment of choice for PD given the progression of other symptoms such as rigidity and bradykinesia. Stimulation of the globus pallidus or the subthalamic nucleus is safe and efficacious in the long-term treatment of all cardinal symptoms of PD, and they are currently the surgeries of choice. Serious adverse events with DBS can occur in 1% to 2% of patients, infection in 5% to 8% of patients, and hardware complications in approximately 25% of patients. Complications associated with DBS are related to the experience of the surgical center. Referring physicians and patients should be aware of the number of surgical procedures and complication rates of any prospective surgical center.
Lyons
Kelly E
KE
Department of Neurology, University of Kansas Medical Center, 3599 Rainbow Boulevard, Mailstop 2012, Kansas City, KS 66160, USA. lyons.kelly@att.net
Pahwa
Rajesh
R
D000818:Animals; D004599:Electric Stimulation Therapy / Q000379:methods*; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology / Q000628:therapy*; D013788:Thalamus / Q000502:physiology*