title: Localization of beta-defensin genes in non human primates.
abstract: Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four beta-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank accession number NM_005218); DEFB4 (h-Bd2, NM_004942.2), DEFB103 (h-BD3, NM_018661); and DEFB104 (hBD4, NM_080389) mapping on chromosome 8p23.22. We have localized beta-defensin genes on metaphasic chromosomes of great apes and several non-human primate species to determine their physical mapping. Using fluorescent in situ hybridization and BAC probes containing the four beta-defensin genes, we have mapped the homologous regions to the beta-defensin genes on chromosome 8p23-p.22 in non-human primates, while no signals were detected on prosimians chromosomes.
authors.forename: M
authors.initials: M
authors.lastname: Ventura
authors.forename: M
authors.initials: M
authors.lastname: Boniotto
authors.forename: M
authors.initials: M
authors.lastname: Pazienza
authors.forename: V
authors.initials: V
authors.lastname: Palumbo
authors.forename: M F
authors.initials: MF
authors.lastname: Cardone
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: A
authors.initials: A
authors.lastname: Tossi
authors.forename: A
authors.initials: A
authors.lastname: Amoroso
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D000882:Haplorhini; D015186:Hominidae; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D011323:Primates / Q000235:genetics*; D023083:beta-Defensins / Q000235:genetics*
chemical_list: D023083:beta-Defensins