Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes.
A cross-sectional analysis was performed to evaluate associations of polymorphisms in the vitamin D receptor (VDR), delta-aminolevulinic acid dehydratase (ALAD), and endothelial nitric oxide synthase (eNOS) genes with patella lead concentrations in 652 lead workers in the Republic of Korea. There was a wide range of patella lead (from below detection limit to 946 microg Pb/g bone mineral), with a mean (standard deviation) of 75.2 (101.0). There were no associations of ALAD or eNOS genotypes with patella lead, but workers with the VDR B allele had significantly (P value < 0.05) higher patella lead (on average, 25% or approximately 6.6 microg Pb/g bone mineral) than lead workers with the VDR bb genotype. There was evidence that the relation between age and patella lead was modified by both the VDR and eNOS genotypes.
Theppeang
Keson
K
Departments of Environmental Health Sciences, Johns Hopkins School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland, USA.
Schwartz
Brian S
BS
Lee
Byung-Kook
BK
Lustberg
Mark E
ME
Silbergeld
Ellen K
EK
Kelsey
Karl T
KT
Parsons
Patrick J
PJ
Todd
Andrew C
AC
D000328:Adult; D000367:Age Factors; D000368:Aged; D015519:Bone Density; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D007855:Lead Poisoning / Q000235:genetics*; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics* / Q000378:metabolism; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis*; D010329:Patella / Q000737:chemistry*; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics* / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D013052:Spectrometry, X-Ray Emission
D018167:Receptors, Calcitriol; D007854:Lead; D019001:Nitric Oxide Synthase; D000623:Porphobilinogen Synthase