Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity.
Eucommia ulmoides leaves have been used as a folk remedy for the treatment of diabetes in Korea. The aim of this study was to isolate and identify the compounds which inhibited advanced glycation end-product formation, one of main molecular mechanisms implicated in diabetic complications. A new flavonol glycoside, quercetin 3-O-alpha-L-arabinopyranosyl-(1-->2)-beta-D-glucopyranoside (1), and known flavonols kaempferol 3-O-beta-D-glucopyranoside (astragalin) (2), quercetin 3-O-beta-D-glucopyranoside (isoquercitrin) (3) were isolated from the leaves of Eucommia ulmoides. These compounds exhibited glycation inhibitory activity comparable to that of aminoguanidine, a known glycation inhibitor. The results suggest that the flavonol glycosides with glycation inhibitory activity could be attributed to the anti-diabetic action of Eucommia ulmoides leaves.
Kim
Hye Young
HY
Food Function Research Division, Korea Food Research Institute, Kyonggi-do 463-746, Republic of Korea. khyey@kfri.re.kr
Moon
Byung Ho
BH
Lee
Hak Ju
HJ
Choi
Don Ha
DH
D000818:Animals; D002417:Cattle; D003920:Diabetes Mellitus / Q000188:drug therapy; D031283:Eucommiaceae; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006031:Glycosylation / Q000187:drug effects; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D012710:Serum Albumin, Bovine
D005419:Flavonoids; D006027:Glycosides; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D012710:Serum Albumin, Bovine