Detection of Epstein-Barr virus in saliva by real-time PCR.
The purpose of this investigation was to assess the salivary levels of Epstein-Barr virus (EBV) in patients with periodontitis using real-time PCR. EBV was detected in 16 out of 33 (48.5%) periodontitis patients and in 3 out of 20(15%) healthy subjects. The baseline mean values for bleeding on probing in EBV-positive patients were significantly higher than those in EBV-negative patients. A significant decrease in EBV levels was observed after initial periodontal treatment. Our findings indicate that levels of EBV in saliva may reflect the status of periodontal inflammation.
Idesawa
M
M
Department of Periodontology, Dental Reseach Center, Nihon University Graduate School of Dentistry, Tokyo, Japan.
Sugano
N
N
Ikeda
K
K
Oshikawa
M
M
Takane
M
M
Seki
K
K
Ito
K
K
D000328:Adult; D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000821:virology*; D016133:Polymerase Chain Reaction; D012463:Saliva / Q000821:virology*