title: Effects of green tea intake on the development of coronary artery disease.
abstract: BACKGROUND
  Green tea, a popular beverage in Japan, contains many polyphenolic antioxidants, which might prevent atherosclerosis. This study was designed to determine whether the consumption of green tea is proportionately associated with a decreased incidence of coronary artery disease (CAD) and the cardiovascular and cerebrovascular prognosis.
  
  
  RESULTS
  The study group comprised 203 patients who underwent coronary angiography (109 patients with significant coronary stenosis and 94 patients without). Predictors for CAD were analyzed and the patients' cardiovascular and cerebrovascular events were followed. Green tea consumption was significantly higher in patients without CAD than in those with CAD (5.9+/-0.5 vs 3.5+/-0.3 cups/day; p<0.001). An inverse relationship between the intake of green tea and the incidence of CAD was observed (p<0.001). The green tea intake per day was an independent predictor for CAD based on a multivariate logistic regression analysis (odds ratio: 0.84 and 95% confidence interval: 0.76-0.91). In contrast, the green tea intake was not a predictor of cardiovascular and cerebrovascular events based on the Cox proportional hazard model.
  
  
  CONCLUSIONS
  Green tea consumption was associated with a lower incidence of CAD in the present study population in Japan. Therefore, the more green tea patients consume, the less likely they are to have CAD.
authors.affiliation: Department of Medicine, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan. sano-123@nms.ac.jp
authors.forename: Junko
authors.initials: J
authors.lastname: Sano
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Inami
authors.forename: Koji
authors.initials: K
authors.lastname: Seimiya
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ohba
authors.forename: Shunta
authors.initials: S
authors.lastname: Sakai
authors.forename: Teruo
authors.initials: T
authors.lastname: Takano
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
mesh_terms: D001628:Beverages; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003327:Coronary Disease / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D011379:Prognosis; D012307:Risk Factors; D013662:Tea
chemical_list: D008055:Lipids; D010936:Plant Extracts; D013662:Tea