[Ethimizol impact on the fatigue of the inspiratory muscles].
The aim of the study was assessment of ethimizol effects on fatigue of respiratory muscles and ventilatory disorders caused by inspiratory resistive load on respiration. Cat experiments showed that administration of ethimizol in inspiratory fatigue reestablishes total bioelectric activity of the inspiratory muscles and diaphragmatic nerve, diminishes useful respiratory cycle and respiration rate. Thus, ethimizol in a 1 mg/kg dose i.v. compensates inspiratory muscular fatigue via central mechanism of action.
Vinogradova
I A
IA
Shevchenko
A I
AI
D000818:Animals; D002415:Cats; D005042:Etimizol / Q000494:pharmacology*; D018763:Muscle Fatigue / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects; D012132:Respiratory Muscles / Q000187:drug effects*
D005042:Etimizol