title: Large-scale genome remodelling by the developmentally programmed elimination of germ line sequences in the ciliate Paramecium.
abstract: In Paramecium, during the development of the somatic macronucleus, precise excision of thousands of single-copy non-coding sequences is initiated by specific DNA double-strand breaks, while imprecise elimination of germ-line-limited repeated sequences leads to internal deletions or chromosome fragmentation. Recent data point to a role of non-coding RNAs in the epigenetic programming of these rearrangements.
authors.affiliation: CNRS UMR 8541, Laboratoire de Génétique Moléculaire, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France. betermie@biologie.ens.fr
authors.forename: Mireille
authors.initials: M
authors.lastname: Bétermier
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics*; D043171:Chromosomal Instability / Q000235:genetics; D004247:DNA; D016054:DNA, Protozoan / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics; D017353:Gene Deletion; D015321:Gene Rearrangement / Q000235:genetics*; D018503:Genome, Protozoan; D010247:Paramecium / Q000235:genetics* / Q000648:ultrastructure; D011123:Polyploidy; D022661:RNA, Untranslated / Q000235:genetics; D017384:Sequence Deletion
chemical_list: D016054:DNA, Protozoan; D022661:RNA, Untranslated; D004247:DNA