Antiproliferative effect of indigoid pigments isolated from human urine.
Two indigoid pigments, red indirubin and blue indigotin, were isolated from the urine of healthy male subjects. The two pigments were assayed on HL60 (human promyelocytic cell line) cells. Preliminary results revealed the antiproliferative effect of the pigments. Indigotin seemed more effective than indirubin.
Conconi
Maria T
MT
Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, I-35131 Padova, Italy. mariateresa.conconi@unipd.it
Parnigotto
Pier P
PP
Costa
Carlo V L
CV
Allegri
Graziella
G
D002455:Cell Division / Q000187:drug effects; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology* / Q000652:urine; D018922:HL-60 Cells; D006801:Humans; D066298:In Vitro Techniques; D007203:Indigo Carmine; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology* / Q000652:urine; D008297:Male
D006131:Growth Inhibitors; D007211:Indoles; D007203:Indigo Carmine; C027185:indirubin