title: Intraductal growth of a nonfunctioning endocrine tumor of the pancreas.
abstract: Intraductal growth of nonfunctioning endocrine tumors of the pancreas may be very rare, and our survey of literature shows only two cases have been described. We report a case of a 43-year-old man with a nonfunctioning endocrine tumor of the pancreas that uniquely grew within the lumen of the main pancreatic duct (MPD) without ductal involvement and completely obstructed the MPD. Endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) were very helpful to delineate the intraductal growth of the tumor and to determine the resection line of the pancreas. A nonfunctioning pancreatic endocrine tumor is important to consider on differential diagnoses when complete obstruction of the MPD is demonstrated on ERCP. It is speculated that the tumor originated from precursor cells of the pancreatic duct or islet cells adjacent to the MPD and slowly proliferated within the lumen of the MPD.
authors.affiliation: Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku-ku, 160-8582, Tokyo, Japan.
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Akatsu
authors.forename: Go
authors.initials: G
authors.lastname: Wakabayashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Aiura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suganuma
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takigawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Wada
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawachi
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanabe
authors.forename: Masakazu
authors.initials: M
authors.lastname: Ueda
authors.forename: Motohide
authors.initials: M
authors.lastname: Shimazu
authors.forename: Michiie
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Masaki
authors.initials: M
authors.lastname: Kitajima
mesh_terms: D000328:Adult; D018273:Carcinoma, Islet Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D019160:Endosonography; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010183:Pancreatic Ducts / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed