Complexes of copper(II) with adenosine or guanosine nucleosides, nucleotides 5'-monophosphate, 2'-deoxynucleosides or 2'-deoxynucleotides 5'-monophosphate in aqueous solution.
In this paper copper(II) complex formation in aqueous solution with a series of nucleosides (adenosine or guanosine) or nucleotides 5'-monophosphate is studied by means of potentiometry, visible spectrophotometry and ultraviolet circular dichroism. A chemical model has been formulated for each binary system (at T= 25 degrees C and I = 0.1 M), with particular attention to the interaction in the basic field. A spectrum (both visible absorption and ultraviolet circular dichroism) for each complex with a significant percentage of formation (in the adopted experimental conditions) has been calculated, allowing structural details to be hypothesised. The interaction with deprotonated alcoholic group(s) of the ribose moiety has been found to be fundamental in determining the co-ordination chemistry of each ligand considered while cases of co-operation between the purine and ribose donor(s) were also considered. Confirmations were also obtained by an investigation on the corresponding 2'-deoxy compounds as ligands.
Daniele
Pier G
PG
Dipartimento di Chimica Analitica dell'Università, Via P. Giuria 5, 10125 Torino, Italy. piergiuseppe.daniele@unito.it
Prenesti
Enrico
E
Berto
Silvia
S
Zelano
Vincenzo
V
Aruga
Roberto
R
D000241:Adenosine / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006151:Guanosine / Q000737:chemistry*; D008024:Ligands; D009711:Nucleotides / Q000737:chemistry*; D013053:Spectrophotometry; D014867:Water
D008024:Ligands; D009711:Nucleotides; D014867:Water; D006151:Guanosine; D003300:Copper; D000241:Adenosine