The heterozygous reeler mouse: behavioural phenotype.
The aim of this study was to investigate whether heterozygous reeler mice (+/rl) could be used as a genetic mouse model of schizophrenia, as previously suggested [J. Med. Chem. 44 (2001) 477]. The behavioural phenotype of male and female +/rl mice (young adult: 50-70 days old, and fully adult: >75 days old) was compared to their wild type (+/+) littermates. A complex behavioural test battery was employed: Irwin test, rotarod, spontaneous locomotor activity, social behaviour, light-dark transition test, startle response and prepulse inhibition, and hot-plate test. Overall, +/rl mice did not differ from their +/+ littermates at either age, although fully adult +/rl male mice spent more time engaged in social investigation. Some of the behavioural measures investigated were influenced by gender. Young female mice were more active in the light/dark transition test than males, while males were more aggressive than females during social interaction. In addition, performance on the rotarod was shown to deteriorate with age. Our data are in agreement with previous findings [Soc. Neurosci. Abst. 27 (2001) 238; J. Psychopharmacol. 17 (2003) A43], but contrary to those of Costa et al. [Curr. Opin. Pharmacol. 2 (2002) 56], although mice used in the present and previous studies were derived from the same genetic stock at Jackson Laboratories, USA. The present study clearly shows that, compared to its +/+ littermates, the +/rl mouse (young/fully adult) exhibits normal behaviour in a wide range of behavioural measures and suggest that these mice may not be suitable for use as a genetic animal model of schizophrenia.
Podhorna
Jana
J
Department of Psychopharmacology, Psychosis, H. Lundbeck A/S, Ottiliavej 9, 2500 Copenhagen-Valby, Denmark. jpod@lundbeck.com
Didriksen
Michael
M
D000161:Acoustic Stimulation / Q000379:methods; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D001007:Anxiety / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D005824:Genetics, Behavioral; D006579:Heterozygote; D007266:Inhibition, Psychological; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology*; D009483:Neuropsychological Tests; D010147:Pain Measurement; D010622:Phencyclidine / Q000494:pharmacology; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D012737:Sex Factors; D012919:Social Behavior
D018691:Excitatory Amino Acid Antagonists; D010622:Phencyclidine