Myosin III illuminates the mechanism of arrestin translocation.
Recent studies have revealed that light adaptation of both vertebrate and invertebrate photoreceptors is accompanied by massive translocations of major signaling proteins in and out of the cellular compartments where visual signal transduction takes place. In this issue of Neuron, Lee and Montell report a breakthrough in understanding the mechanism of arrestin translocation in Drosophila. They show that arrestin is carried into the light-sensitive microvilli by phosphoinositide-enriched vesicles driven by a myosin motor.
Strissel
Katherine J
KJ
Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Arshavsky
Vadim Y
VY
D000818:Animals; D000221:Adaptation, Ocular / Q000235:genetics / Q000502:physiology; D019390:Arrestins / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D008871:Microvilli / Q000378:metabolism / Q000648:ultrastructure; D025102:Myosin Type III / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism / Q000648:ultrastructure; D021381:Protein Transport / Q000235:genetics; D022161:Transport Vesicles / Q000378:metabolism / Q000648:ultrastructure
D019390:Arrestins; D025102:Myosin Type III; D010716:Phosphatidylinositols; D010750:Phosphoproteins