Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung.
Oxidants are known to modulate cell proliferation and apoptosis, and induce synthesis of growth factors that play an important role in tumor growth and invasion. Antioxidant enzymes and thiol proteins regulating cellular redox state constitute the major cellular protection against oxidants. Consequently, they are also associated both with carcinogenesis and tumor progression. Superoxide dismutases, glutamate cysteine ligase, catalase, thioredoxins and peroxiredoxins, which are the most important of these enzymes, are expressed in lung malignancies, and especially in pleural mesothelioma. This has consequences not only for tumor behavior but also for resistance of tumor cells to cytotoxic drugs and radiation.
Kinnula
Vuokko L
VL
Department of Medicine, Division of Pulmonary Diseases, University of Helsinki and Helsinki University Hospital, P.O. Box 22 (Haartmaninkatu 4), 00014 Helsinki, Finland. vuokko.kinnula@helsinki.fi
Pääkkö
Paavo
P
Soini
Ylermi
Y
D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D018450:Disease Progression; D005721:Glutamate-Cysteine Ligase / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology*; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism; D054464:Peroxiredoxins; D013482:Superoxide Dismutase / Q000378:metabolism; D013879:Thioredoxins / Q000378:metabolism
D000975:Antioxidants; D013879:Thioredoxins; D010544:Peroxidases; D054464:Peroxiredoxins; D002374:Catalase; D013482:Superoxide Dismutase; D005721:Glutamate-Cysteine Ligase