No findings of dental defects in children treated with minocycline.
Forty-one children <8 years of age treated for brucellosis with oral minocycline (2.5 mg/kg) twice daily for 3 weeks were recalled and examined to check for dental staining and defects. Dental staining and defects were found in 14 of 41 exposed children (34.1%) and in 30 of 82 matched controls (36.6%), respectively (P > 0.2).
Cascio
Antonio
A
Instituto di Patologia Infettiva e Virologia, G. Di Cristina Hospital, Università di Palermo, Palermo, Italy. acascio@unime.it
Di Liberto
Chiara
C
D'Angelo
Matteo
M
Iaria
Chiara
C
Scarlata
Francesco
F
Titone
Lucina
L
Campisi
Giuseppina
G
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D002006:Brucellosis / Q000188:drug therapy / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D003743:Dental Enamel / Q000473:pathology; D006801:Humans; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use; D014076:Tooth Diseases / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D008911:Minocycline; D012293:Rifampin