New surface-active polymers for ophthalmic formulations: evaluation of ocular tolerance.
Two n-octenylsuccinate starch (AS) types of unknown molecular weights were assessed for ocular tolerance. Irritation potential of different solutions (containing 2 and 15% (w/w) AS) and AS stabilized emulsions (containing 15% (w/w) AS) was evaluated in vivo in rabbit eyes, using a confocal laser scanning microscope, and in vitro on treated excised pig corneas by light microscopy of histological cross sections. Both AS types were previously characterized by viscosity, osmolality and surface tension measurements. All tested solutions and emulsions showed good eye tolerance regardless of concentration and emulsifying properties suggesting AS to be a good alternative to commonly used solubilizing or emulsifying agents in ophthalmic formulations.
Baydoun
Luma
L
Institut für Pharmazeutische Technologie, Technische Universität Braunschweig, Braunschweig, Germany.
Furrer
Pascal
P
Gurny
Robert
R
Müller-Goymann
Christel C
CC
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003315:Cornea / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004361:Drug Tolerance; D005260:Female; D008297:Male; D011108:Polymers / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D011817:Rabbits; D013501:Surface-Active Agents / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D013552:Swine
D011108:Polymers; D013501:Surface-Active Agents