[Angioedema and angiotensin converting enzyme inhibitors: a report of 19 cases].
OBJECTIVE
Inhibitors of angiotensin-converting enzyme are worldwide used and are a real progress for the treatment of systemic hypertension or cardiac failure and are a real progress. The most common adverse side effect is cough. Angioedema is a sudden and localized edema involving the deeper cutaneous and mucosa tissue lappers. 0.1-0.5% of patients treated by ACE inhibitors could develop angioedema.


METHODS
We report a series of 19 cases, recruited in the Parmacovigilance Center of the University Hospital of Amiens from 1997 to 2003.


RESULTS
All the patients had a facial swelling edema at initial presentation. Intestinal mucosa or preputial are misleading localisations. In 1/3 of cases, angioedema appeared after the first administration, in 1/3 of cases it appeared with a delay of 1-2 years. The oropharynx localisation with glottic involvement may need an airway intervention. One patient died from pulmonary distress at home.


CONCLUSIONS
The pathophysiology is current unknown although there is increasing evidence for bradykinin accumulation involvement. The treatment by ACE inhibitors must be broken off; angiotensin II antagonists may be an alternative treatment, but has to be introduced carefully.
Ducroix
J-P
JP
Service de médecine interne, CHU Amiens Nord, place Victor-Pauchet, 80054 Amiens cedex 1, France. ducroix.jean-pierre@chu-amiens.fr
Outurquin
S
S
Benabes-Jezraoui
B
B
Gras
V
V
Chaby
G
G
Strunski
V
V
Salle
V
V
Smail
A
A
Lok
C
C
Andrejak
M
M
D000328:Adult; D000368:Aged; D000799:Angioedema / Q000139:chemically induced*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D001920:Bradykinin / Q000494:pharmacology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance
D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin