[Determination of beta-hexosaminidase and gamma-glutamyltranspeptidase activities in urine of pregnant women to monitor alcohol consumption].
BACKGROUND
Drinking of alcohol by pregnant women provokes many fetal development disorders, first of all the function of central nervous system and can lead to Fetal Alcohol Syndrome - FAS.


OBJECTIVE
Aims of investigation were to determine beta - hexosaminidase (HEX) and gamma - glutamyltranspeptidase (GGT) activity in the urine to monitoring consumption of alcohol by pregnant women in first trimester and to assess the effect of ethyl alcohol on fetus development.


METHODS
22 pregnant women, who did not declare consumption of ethanol containing drinks. The level of creatinine, GGT and HEX in urine was analysed.


RESULTS
Preliminary results of our study indicate that determination of GGT and HEX activities could be useful in monitoring of alcohol consumption during pregnancy.
Niemiec
Krzysztof Tomasz
KT
Klinika Połoznictwa i Ginekologii, Instytut Matki i Dziecka, Kasprzaka 17a, 01-211 Warszawa, Poland.
Raczynski
Piotr
P
Laskowska-Klita
Teresa
T
Czerwinska
Barbara
B
Zawartka-Bielas
Anna
A
Leibschang
Jerzy
J
Pawlowska
Adriana
A
D000428:Alcohol Drinking / Q000652:urine*; D003401:Creatine / Q000652:urine; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000517:prevention & control; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D001619:beta-N-Acetylhexosaminidases / Q000652:urine*; D005723:gamma-Glutamyltransferase / Q000652:urine*
D000431:Ethanol; D005723:gamma-Glutamyltransferase; D001619:beta-N-Acetylhexosaminidases; D003401:Creatine