A chondroitin sulfate small molecule that stimulates neuronal growth.
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the growth and differentiation of neurons. These studies represent the first, direct investigations into the structure-activity relationships of chondroitin sulfate using homogeneous synthetic molecules and define a tetrasaccharide as a minimal motif required for activity.
Tully
Sarah E
SE
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Mabon
Ross
R
Gama
Cristal I
CI
Tsai
Sherry M
SM
Liu
Xuewei
X
Hsieh-Wilson
Linda C
LC
D000818:Animals; D002478:Cells, Cultured; D002809:Chondroitin Sulfates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006624:Hippocampus; D008856:Microscopy, Fluorescence; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000378:metabolism
D009844:Oligosaccharides; D002809:Chondroitin Sulfates