Targeting plasmid-encoded proteins to the antigen presentation pathways.
The antigen presentation pathways constitute a fulcrum on which adaptive immunity is balanced, and their manipulation should allow us to induce designer immune responses. The ease and rapidity with which DNA vaccines can be constructed and altered make them ideal candidates with which to test the various targeting strategies that have been conceived to date. These approaches and the mechanisms that may (or may not) underlie their success are reviewed in this article.
Leifert
Jens A
JA
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Rodriguez-Carreno
Maria P
MP
Rodriguez
Fernando
F
Whitton
J Lindsay
JL
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D045142:Cross-Priming / Q000276:immunology; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D010957:Plasmids / Q000235:genetics* / Q000276:immunology; D011506:Proteins / Q000235:genetics / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D019444:Vaccines, DNA / Q000235:genetics / Q000276:immunology*
D000939:Epitopes; D006649:Histocompatibility Antigens; D011506:Proteins; D011948:Receptors, Antigen, T-Cell; D019444:Vaccines, DNA