title: Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure.
abstract: A single-step acylation of rutin and naringin, catalyzed by immobilized Candida antarctica lipase B in 2-methyl-2-butanol, occurred preferentially on the primary hydroxyl group. Using palmitic methyl ester as acyl donor, the acylation rate of naringin was 10-fold higher than that of rutin. Under optimal conditions, i.e. a molar ratio acyl donor/naringin of 7:1 and 200 mbar, 92% naringin was acylated.
authors.affiliation: Ecole Supérieure de Technologie des Biomolécules de Bordeaux, Université Victor Segalen Bordeaux2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Passicos
authors.forename: Xavier
authors.initials: X
authors.lastname: Santarelli
authors.forename: Denis
authors.initials: D
authors.lastname: Coulon
mesh_terms: D000215:Acylation; D002175:Candida / Q000201:enzymology*; D002384:Catalysis; D004951:Esterification; D005419:Flavonoids / Q000378:metabolism*; D008049:Lipase / Q000378:metabolism*; D011312:Pressure
chemical_list: D005419:Flavonoids; D008049:Lipase