Cytomegalovirus and chronic allograft rejection in liver transplantation.
Cytomegalovirus (CMV) remains one of the most frequent viral infections and the most common cause of death after liver transplantation (LT). Chronic allograft liver rejection remains the major obstacle to long-term allograft survival and CMV infection is one of the suggested risk factors for chronic allograft rejection. The precise relationship between cytomegalovirus and chronic rejection remains uncertain. This review addresses the morbidity of cytomegalovirus infection and the risk factors associated with it, the relationship between cytomegalovirus and chronic allograft liver rejection and the potential mechanisms of it.
Gao
Liang-Hui
LH
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, PO Box 4193, Hubin Campus, 353 Yan'an Road, Hangzhou 310031, Zhejiang Province, China. gaolh@zju.edu.cn
Zheng
Shu-Sen
SS
D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000276:immunology / Q000401:mortality*; D006084:Graft Rejection / Q000276:immunology / Q000401:mortality* / Q000821:virology*; D006801:Humans; D016031:Liver Transplantation; D012307:Risk Factors