title: Possible mechanism of flicking-induced short-term plasticity in retinal cone-LHC synapse: a computational study.
abstract: In retinal cone-HC synapse, it has been found that repetitive stimulation could induce postsynaptic short-term responsiveness enhancement. However, the detailed mechanism underlying this short-term plasticity in the retinal graded neurons remains unclear. In this study, based on an ion-channel model described using Hodgkin--Huxley equations, the possible mechanism of repetitive-stimulation-induced short-term plasticity in the synapse between retinal cones and horizontal cells was investigated. The computational simulation results, together with evidence from experimental observations, suggest that the short-term modification of signal transmission between the retinal graded neurons is likely to be attributed to the regulatory effects that calcium-dependent process exerts on the single-channel properties of the postsynaptic AMPA receptors.
authors.affiliation: Department of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Hua-Shan Road, Shanghai 200030, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jin
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Hu
authors.forename: Pei-Ji
authors.initials: PJ
authors.lastname: Liang
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods; D006054:Goldfish; D009473:Neuronal Plasticity / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods*; D017949:Retinal Cone Photoreceptor Cells / Q000502:physiology*; D013569:Synapses / Q000502:physiology*