Typhoid fever as a rare cause of hepatic, splenic, and bone marrow granulomas.
During the course of typhoid fever, the usual histologic finding of the liver is "nonspecific reactive hepatitis." Hepatic granuloma (HG) is a rare complication of typhoid fever. We present two cases of typhoid fever with HG and review the relevant literature. Case 1 (a 53-year-old female) was found to have both hepatic and splenic granulomas. This is the first case of typhoid fever with splenic granulomas in the English language literature. Case 2 (a 66-year-old male) developed granulomas in the bone marrow in addition to HG. It should be considered that typhoid fever may lead to granulomas in several organs.
Mert
Ali
A
Cerrahpasa Medical Faculty, Infectious Diseases and Clinical Microbiology, University of Istanbul, 34303 Aksaray, Istanbul, Turkey.
Tabak
Fehmi
F
Ozaras
Resat
R
Ozturk
Recep
R
Aki
Hilal
H
Aktuglu
Yildirim
Y
D000368:Aged; D001707:Biopsy, Needle; D001855:Bone Marrow Diseases / Q000209:etiology / Q000473:pathology*; D002701:Chloramphenicol; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D035583:Rare Diseases; D012720:Severity of Illness Index; D013158:Splenic Diseases / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome; D014435:Typhoid Fever / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D002701:Chloramphenicol