Synthesis and antimycobacterial activity of some beta-carboline alkaloids.
In view of the attributed medicinal properties of beta-carboline alkaloids, some new O-acyl derivatives of beta-carboline alkaloid--harmol, were prepared and tested for possible antimycobacterial activity against Mycobacterium tuberculosis H37Rv.
Begum
Sabira
S
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan. sabira@khi.comsats.net.pk
Hassan
Syed Imran
SI
Siddiqui
Bina S
BS
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002243:Carbolines / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D032443:Peganum; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy
D000470:Alkaloids; D000995:Antitubercular Agents; D002243:Carbolines; D010936:Plant Extracts