title: Myofibrillar myopathy with desmin accumulation in a young Australian Shepherd dog.
abstract: A 1-year-old male neutered Australian Shepherd dog was referred to a veterinary specialist for evaluation of chronic lameness, contractures, and exercise intolerance. Serum creatine kinase was elevated, and electromyography showed complex repetitive discharges. Cardiomyopathy was clinically identified. Muscle biopsies evaluated by light and electron microscopy, and immunohistochemistry revealed the presence of a myofibrillar myopathy with accumulation of desmin and other proteins. These observations represent the first report of myofibrillar myopathy in the dog.
authors.affiliation: Department of Pathology, University of California San Diego, La Jolla, CA 92093-0709, USA. gshelton@ucsd.edu
authors.forename: G Diane
authors.initials: GD
authors.lastname: Shelton
authors.forename: Veronique
authors.initials: V
authors.lastname: Sammut
authors.forename: Saschiko
authors.initials: S
authors.lastname: Homma
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takayama
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Mizisin
mesh_terms: D000818:Animals; D003893:Desmin / Q000378:metabolism*; D004285:Dogs; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008854:Microscopy, Electron; D009135:Muscular Diseases / Q000378:metabolism* / Q000473:pathology*; D009210:Myofibrils / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D013194:Staining and Labeling
chemical_list: D003893:Desmin