Hot +TIPS: guidance cues signal directly to microtubules.
Plus end tracking proteins (+TIPS) bind to microtubules. Results reported by Lee et al. and Zhou et al. in this issue of Neuron demonstrate that, via intracellular pathways signaling to +TIPs, microtubules can be a direct target of guidance cues in steering growth cones and regulating axon elongation.
Kalil
Katherine
K
Department of Anatomy, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dent
Erik W
EW
D000818:Animals; D001369:Axons / Q000502:physiology*; D002478:Cells, Cultured; D020439:Growth Cones / Q000502:physiology*; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
D008869:Microtubule-Associated Proteins