title: [Water balance and pharmacokinetics of ketamine during anesthesia in roentgen-endovascular procedures in children].
abstract: Forty-seven children, aged 2 to 12, with different pathologies, who underwent the abdominal aortography with the bolus introduction of 60% verografin, i.e. a radiopaque contrast agent (RCA), 2-3 ml/kg for 2-3 sec. The osmolar index of blood went up sharply, diuresis increased 7-fold and the aldosterone content topped 2-fold the original level. Simultaneously, the plasma concentration of ketamine was reducing by 2 times faster than in children who were not administered RCA. An additional introduction of an anesthetic made on minute 3 after RCA injection was suggested to modify the anesthesia management scheme.
authors.forename: V V
authors.initials: VV
authors.lastname: Lazarev
authors.forename: V A
authors.initials: VA
authors.lastname: Mikhel'son
authors.forename: A A
authors.initials: AA
authors.lastname: Burakov
authors.forename: B N
authors.initials: BN
authors.lastname: Izotov
authors.forename: S A
authors.initials: SA
authors.lastname: Savchuk
mesh_terms: D000768:Anesthesia, General; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D001027:Aortography; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000008:administration & dosage*; D004231:Diuresis; D006801:Humans; D007649:Ketamine / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D009994:Osmolar Concentration; D014882:Water-Electrolyte Balance
chemical_list: D003287:Contrast Media; D007649:Ketamine