title: Prospective randomized study of viscous lidocaine versus benzocaine in a GI cocktail for dyspepsia.
abstract: We hypothesized that Benzocaine (Hurricaine) would work as quickly and effectively as viscous Lidocaine in this preparation. This was a prospective randomized, single-blinded comparison between Benzocaine and Lidocaine as the topical anesthetic in a gastrointestinal (GI) cocktail. Patients 18 years or older were approached for participation when a GI cocktail was ordered by the Emergency Physician. Patients were randomized to equivalent doses of either Benzocaine or viscous Lidocaine in addition to 30 cc of Maalox and 10 cc of Donnatal. Assessment using a visual analog pain scale occurred at time intervals of 0, 5, 15, and 30 min. Eighty-two patients were enrolled (44 to Benzocaine, 38 to viscous Lidocaine), with each group having a statistically significant improvement in pain (p < 0.001). There were no statistical differences between the Benzocaine and viscous Lidocaine groups in terms of the relief of symptoms at each of the assessment times. There were no adverse outcomes in either group.
authors.affiliation: Department of Emergency Medicine, University of California-San Diego Medical Center, 200 West Arbor Drive, Mailcode #8676, San Diego, CA 92103, USA.
authors.forename: Gary M
authors.initials: GM
authors.lastname: Vilke
authors.forename: Albert
authors.initials: A
authors.lastname: Jin
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Davis
authors.forename: Theodore C
authors.initials: TC
authors.lastname: Chan
mesh_terms: D000328:Adult; D000536:Aluminum Hydroxide / Q000008:administration & dosage; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage; D001285:Atropine / Q000008:administration & dosage; D001566:Benzocaine / Q000008:administration & dosage*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008276:Magnesium Hydroxide / Q000008:administration & dosage; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage; D011446:Prospective Studies; D012601:Scopolamine / Q000008:administration & dosage; D012841:Simethicone / Q000008:administration & dosage; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D000863:Antacids; C069202:Donnatal; D004338:Drug Combinations; C008570:aluminum hydroxide, magnesium hydroxide, simethicone drug combination; D000536:Aluminum Hydroxide; D001285:Atropine; D012841:Simethicone; D008012:Lidocaine; D012601:Scopolamine; D008276:Magnesium Hydroxide; D001566:Benzocaine; D010634:Phenobarbital