Massive pulmonary embolism in a young patient on clozapine therapy.
Clozapine-associated induction of venous thromboembolism has potentially catastrophic consequences. We report a case of sudden death caused by bilateral main pulmonary trunk thrombosis in a 31-year-old man receiving clozapine therapy. The patient presented with general weakness and exertional dyspnea. Bilateral main pulmonary trunk thrombosis was clearly demonstrated by helical chest computed tomography.
Yang
Tung-Ying
TY
Department of Emergency Medicine, Chang Gung Memorial Hospital-Kaohsiung, 123 Ta-Pei Road, Niao Sung Hsiang, Kaohsiung Hsien 833, Taiwan, R.O.C.
Chung
Kun-Jung
KJ
Huang
Tiao-Lai
TL
Kung
Chia-Te
CT
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D003645:Death, Sudden / Q000209:etiology; D004635:Emergency Medicine / Q000379:methods; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D011655:Pulmonary Embolism / Q000139:chemically induced* / Q000175:diagnosis; D012559:Schizophrenia / Q000188:drug therapy*; D016312:Treatment Refusal
D014150:Antipsychotic Agents; D003024:Clozapine