[Influence of combined iodine and fluoride on phospholipid and fatty acid composition in brain cells of rats].
OBJECTIVE
Investigating the influence of combined iodine and fluoride on phospholipid and fatty acid composition in brain cells of rats.


METHODS
Five groups of rats were provided with deionized drinking water containing 0 and 150 mg/L NaF, and containing both 150 mg/L NaF and 0.003, 0.03 or 3 mg/L KI respectively for 5 months. Then phospholipid and fatty acid composition were determined using liquid chromatography.


RESULTS
The phospholipid composition had no obvious change. The high concentration fluoride (150 mg/L) and high concentration Iodine (3 mg/L) with high concentration fluoride could cause significant changes of the fatty acid composition in brain cells of rats, the proportion of unsaturated fatty acid (C18:2) was significantly decreased and the saturated fatty acid (C12:0) increased obviously. The antagonistic action of 0.03 mg/L KI drinking water on this kind of influence induced by 150 mg/L NaF was the most evident, whereas that of 3 mg/L KI was action of synergetic toxicity.


CONCLUSIONS
Fluorosis had obvious influence on phospholipid and fatty acid composition in brain cells of rats, and its mechanism might be associated with action of lipid peroxidation, and 0.03 mg/L KI is the optimal concentration for the antagonistic action with this influence from fluorosis.
Shen
Xiuying
X
College of Life and Enviroment Science, Zhejiang Normal University, Jinhua 321004, China.
Zhang
Zigui
Z
Xu
Xiaolu
X
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry / Q000187:drug effects*; D002462:Cell Membrane / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D008297:Male; D010743:Phospholipids / Q000032:analysis*; D011193:Potassium Iodide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012969:Sodium Fluoride / Q000037:antagonists & inhibitors / Q000633:toxicity*
D005227:Fatty Acids; D010743:Phospholipids; D011193:Potassium Iodide; D012969:Sodium Fluoride