title: Recurrent calcium nephrolithiasis associated with primary aldosteronism.
abstract: Typical manifestations of hyperaldosteronism include salt retention, hypokalemia, and metabolic alkalosis. However, a consequence infrequently recognized and described is hypocitraturia. In combination with hypercalciuria, aldosterone-induced hypocitraturia can trigger calcium nephrolithiasis. The authors report a case of an individual with primary hyperaldosteronism from an adrenal adenoma that resulted in hypocitraturia. The patient had severe recurrent renal calcium calculi that corrected with adrenalectomy. The clinical physiology of renal calcium and citrate handling in hyperaldosteronism is reviewed.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8885, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Shey
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Cameron
authors.forename: Khashayar
authors.initials: K
authors.lastname: Sakhaee
authors.forename: Orson W
authors.initials: OW
authors.lastname: Moe
mesh_terms: D000307:Adrenal Gland Diseases / Q000150:complications / Q000000981:diagnostic imaging; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology; D000315:Adrenalectomy; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D002951:Citrates / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D006965:Hyperplasia / Q000000981:diagnostic imaging; D006973:Hypertension / Q000150:complications; D007008:Hypokalemia / Q000150:complications; D007669:Kidney Calculi / Q000737:chemistry / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014057:Tomography, X-Ray Computed
chemical_list: D002951:Citrates; D002118:Calcium