title: Evaluation of the effect of radiotherapy for pituitary tumours on cognitive function and quality of life.
abstract: OBJECTIVE
  Pituitary tumours are often treated with radiotherapy, which can cause cognitive impairment when given in high doses. It is assumed that current regimens do not cause damage, but this has not been established. The aim was to determine whether radiotherapy given to people with pituitary tumours was associated with cognitive impairment and reduced quality of life.
  
  
  METHODS
  We retrospectively compared two outcome groups (patients with pituitary tumours who had undergone radiotherapy and surgery and patients with pituitary tumours who had surgery alone), and carried out standardised tests of cognitive function and quality of life.
  
  
  RESULTS
  The data suggested that patients with pituitary tumours treated with surgery, with or without radiotherapy, had cognitive impairment compared with the normal population. Patients receiving radiotherapy performed significantly worse than those receiving only surgery on the Stroop test, a measure of executive function. They also scored significantly lower on the Physical Health composite of the SF36, although this difference was no longer significant when account was taken of baseline differences between the groups. There were no significant differences in other cognitive functions, mood, general well-being or the Mental Health Composite of the SF36.
  
  
  CONCLUSIONS
  Patients treated for pituitary disease may have cognitive impairment. A decrease in cognitive function was found regardless of treatment type. The decrease seemed to be greater in the radiotherapy group and was mainly on executive function. This impairment of executive function could affect daily life. Further prospective studies are required to assess the effect of pituitary disease on cognitive function and the safety of radiotherapy.
authors.affiliation: School of Psychology, University of Nottingham, Nottingham, UK.
authors.forename: R
authors.initials: R
authors.lastname: Noad
authors.forename: K R
authors.initials: KR
authors.lastname: Narayanan
authors.forename: T
authors.initials: T
authors.lastname: Howlett
authors.forename: N B
authors.initials: NB
authors.lastname: Lincoln
authors.forename: R C L
authors.initials: RC
authors.lastname: Page
mesh_terms: D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010910:Pituitary Irradiation / Q000009:adverse effects; D010911:Pituitary Neoplasms / Q000523:psychology* / Q000532:radiotherapy* / Q000601:surgery; D011788:Quality of Life; D012189:Retrospective Studies; D016896:Treatment Outcome