Carbohydrate-based therapeutics.
In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.
Osborn
Helen M I
HM
School of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK. h.m.i.osborn@rdg.ac.uk
Evans
Philip G
PG
Gemmell
Natasha
N
Osborne
Sadie D
SD
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001428:Bacterial Vaccines; D002241:Carbohydrates / Q000096:biosynthesis / Q000276:immunology* / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006025:Glycosaminoglycans / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors; D006801:Humans; D037102:Lectins / Q000378:metabolism; D011135:Polysaccharides, Bacterial / Q000276:immunology
D000890:Anti-Infective Agents; D000911:Antibodies, Monoclonal; D001428:Bacterial Vaccines; D002241:Carbohydrates; D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans; D037102:Lectins; D011135:Polysaccharides, Bacterial; D016695:Glycosyltransferases; D006026:Glycoside Hydrolases