Leishmanicidal activity of phenylene bridged C2 symmetric glycosyl ureides.
A number of phenylene bridged C2 symmetric glycosyl uerides with ester (3a-f), alcohol (4a-c) and acid (5a-d) functionalities were prepared by addition of glycosyl amino esters with phenyl diisocyanates and their further reaction with LiAlH(4) or hydrolysis with LiOH. All the compounds were screened for their in vitro and in vivo antileishmanial activity. Most of the compounds exhibited good activity while two of the compounds 3e and 3f reduced the clinical dose of standard drug SSG.
Tewari
Neetu
N
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
Ramesh
Mishra
R C
RC
Tripathi
R P
RP
Srivastava
V M L
VM
Gupta
Suman
S
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects*; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000981:Antiprotozoal Agents