title: Virus PCR assay panels: an alternative to the mouse antibody production test.
abstract: Antibody production tests have traditionally been used to test biological materials for viral contamination. Now molecular biology techniques have emerged as an alternative. The authors compare MAP testing with PCR-based detection methods, focusing on differences in animal use, laboratory requirements, sample size, and limits of detection.
authors.affiliation: Charles River Laboratories, 251 Ballardvale Street, Wilmington. MA 01887, USA.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Blank
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Henderson
authors.forename: Lisa A
authors.initials: LA
authors.lastname: White
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D007159:Immunologic Tests / Q000379:methods*; D051379:Mice; D016133:Polymerase Chain Reaction; D012376:Rodent Diseases / Q000175:diagnosis / Q000821:virology*; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA / Q000379:methods; D013997:Time Factors; D014777:Virus Diseases / Q000175:diagnosis / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral