title: Modulation of tachykinin and cytokine release in patients with coronary disease undergoing percutaneous revascularization.
abstract: Plasma levels of substance P (SP) and neurokinin A (NKA) tachykinin and of gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) cytokines were assayed in plasma obtained from peripheral blood of 19 patients presenting with stable chronic coronary stenosis and 12 patients with acute coronary syndrome (ACS). Plasma samples were obtained before, during, and after percutaneous coronary intervention (PCI) consisting of implantation of a metallic stent. Fourteen healthy subjects without any evident risk factors for coronary artery disease (CAD) were also included for comparison at basal time. We found that plasma levels of both IFN-gamma and TNF-alpha were significantly higher in patients with chronic or acute CAD than those in control subjects at the time of presentation. NKA and IFN-gamma levels were also significantly increased in ACS patients compared with those in patients with stable disease. The analysis performed during and after PCI revealed that IFN-gamma levels increased 15 min after stent implantation in both chronic and ACS patients and that TNF-alpha levels increased in chronic patients only compared to basal values. In addition, a significant decrease of both NKA and SPA levels 48 h after the end of the revascularization procedure was observed in ACS patients. These data suggest that modulation of tachykinin and/or cytokine release with proinflammatory activity in chronic or acute cardiac ischemia and during following coronary stenting might play an important role in heart tissue damage and in long-term inflammatory complications of PCI.
authors.affiliation: Dipartimento di Medicina Interna, Università La Sapienza, Viale del Policlinico 155, 00161, Rome, Italy. marino.paroli@uniroma1.it
authors.forename: Marino
authors.initials: M
authors.lastname: Paroli
authors.forename: Paola
authors.initials: P
authors.lastname: Mariani
authors.forename: Daniele
authors.initials: D
authors.lastname: Accapezzato
authors.forename: Mariadomenica
authors.initials: M
authors.lastname: D'Alessandro
authors.forename: Cristian
authors.initials: C
authors.lastname: Di Russo
authors.forename: Maura
authors.initials: M
authors.lastname: Bifolco
authors.forename: Maria Isabella
authors.initials: MI
authors.lastname: Sirinian
authors.forename: Francesco
authors.initials: F
authors.lastname: Fedele
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Bruno
authors.forename: Gennaro
authors.initials: G
authors.lastname: Sardella
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003324:Coronary Artery Disease / Q000097:blood* / Q000276:immunology / Q000628:therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015288:Neurokinin A / Q000097:blood* / Q000276:immunology; D013373:Substance P / Q000097:blood* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D013373:Substance P; D007371:Interferon-gamma; D015288:Neurokinin A