title: Botulinum neurotoxin for the treatment of migraine and other primary headache disorders.
abstract: Clinical data and experience to date have demonstrated that BoNT-A is an effective and well-tolerated therapy for the prevention of migraine and other headache disorders. It has a long duration of action that may last over 4 months with no systemic or serious AEs. Several issues remain to be defined, however, including dosing, location, and number of injections; optimal dilution of BoNT-A; specific headache types that respond best to BoNT-A; and long-term efficacy and safety. Data from ongoing well-designed trials that include a larger patient population investigating these issues may confirm a role for BoNT-A as a first-line agent for migraine prevention. Neurotoxin therapy is part of a broader headache management approach. Because the injection techniques for headache are unique and vary depending on the primary headache disorder being treated and the location and pattern of pain referral, the use of BoNT-A for headache is not simply an extension of its use for cosmesis. The use of BoNT-A in the overall management of primary headache disorders should be reserved for medical practitioners who not only have experience with BoNT-A injections, but possess the expertise in the diagnosis and management of complex headache disorders. Educating patients and addressing headache triggers and optimizing acute treatment improve the outcome of any preventive program.
authors.affiliation: Department of Neurology, Kaiser Permanente, 4405 Vandever Avenue, San Diego, CA 92120, USA. Andrew.m.Blumenfeld@kp.org
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Blumenfeld
authors.forename: David W
authors.initials: DW
authors.lastname: Dodick
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Silberstein
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D006261:Headache / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D007273:Injections, Intramuscular; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control; D009465:Neuromuscular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D012449:Safety; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A