title: 3D micro-CT images of ossicles destroyed by middle ear cholesteatoma.
abstract: OBJECTIVE
  To reconstruct the 3D structures of normal ossicles and ossicles destroyed by different cholesteatomas, and to compare the volume fractions of the two types of ossicles.
  
  
  METHODS
  Thirteen pathological ossicles from four kinds of middle ear cholesteatoma obtained during surgery were used. Normal ossicles harvested from cadaveric temporal bone specimens were used as controls. The structures of the ossicles were analyzed using micro-CT by filming 2D cross-sectional images perpendicular to the long axis, from which 3D images were reconstructed. The volume fraction was measured using a CT-Analyzer and Ant.
  
  
  RESULTS
  The volume fraction, indicating the relative strength of normal ossicles, was lower in the portion close to the articular surface. As the four types of cholesteatoma were found to express their patterns of destruction at various sites in the ossicles, they revealed a different volume fraction in each ossicle.
  
  
  CONCLUSIONS
  Our preliminary data on ossicular structure obtained using micro-CT will be helpful for elucidating the normal and pathological structure of ossicles and for the further development of artificial prostheses.
authors.affiliation: Department of Otolaryngology, Ajou University School of Medicine, Suwon, South Korea. parkkh@madang.ajou.ac.kr
authors.forename: Keehyun
authors.initials: K
authors.lastname: Park
authors.forename: Sung-Kyun
authors.initials: SK
authors.lastname: Moon
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Cho
authors.forename: Ye Yeon
authors.initials: YY
authors.lastname: Won
authors.forename: Myon Ghyun
authors.initials: MG
authors.lastname: Baek
mesh_terms: D018424:Cholesteatoma, Middle Ear / Q000000981:diagnostic imaging* / Q000473:pathology; D004429:Ear Ossicles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008852:Microradiography; D014057:Tomography, X-Ray Computed