Inhibitory effect of Yunbutang on mast cell-dependent allergic reactions.
Yunbutang (YB) is an Oriental herbal prescription, which has been successfully applied for the treatment of allergic disorders, mainly atopic dermatitis in clinical medicine. However, its effect in experimental models remains unknown. Here, we report inhibitory effects of YB on mast cell-dependent immediate-type allergic reactions. YB inhibited systemic allergic reaction induced by compound 48/80. YB dose-dependently inhibited the histamine release from the mast cells activated by compound 48/80. YB also showed an inhibitory effect of anti-dinitrophenyl IgE antibody-induced passive cutaneous anaphylaxis reaction by oral administration. Furthermore, YB inhibited tumor necrosis factor-alpha secretion from stimulated mast cells. These findings provide evidence that YB inhibits the mast cell-dependent allergic reactions.
Na
Ho-Jeong
HJ
Department of Pharmacology, College of Oriental Medicine, Kyung Hee University, Seoul, South Korea.
Moon
Phil-Dong
PD
Hong
Seung-Heon
SH
Shin
Jo-Young
JY
Kim
Hyung-Min
HM
D000818:Animals; D002460:Cell Line; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007723:Korea; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology*; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects* / Q000276:immunology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000633:toxicity
D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D003189:p-Methoxy-N-methylphenethylamine