[Molecular genetic susceptibility to lead poisoning].
It was reported that three polymorphic genes were identified to be able to potentially influence the bioaccumulation and toxicokinetics of lead in humans. These genes are delta-aminolevulinic acid dehydratase(ALAD) gene, vitamin D receptor (VDR) and hemochromatosis gene. Their relation to susceptibility to lead poisoning in humans was reviewed in this paper.
Wu
Shenghu
S
Xinhua Hospital, Research Center for Pediatric Environmental Science, Shanghai Second Medical University, Shanghai 200092, China.
Yan
Chenghuai
C
Shen
Xiaoming
X
D004781:Environmental Exposure; D058851:GPI-Linked Proteins; D020022:Genetic Predisposition to Disease; D006432:Hemochromatosis / Q000235:genetics; D000071020:Hemochromatosis Protein; D006801:Humans; D007855:Lead Poisoning / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics; D016273:Occupational Exposure; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*
D058851:GPI-Linked Proteins; C481006:HJV protein, human; D000071020:Hemochromatosis Protein; D008565:Membrane Proteins; D018167:Receptors, Calcitriol; D000623:Porphobilinogen Synthase