Cell culture and animal models of viral hepatitis. Part I: hepatitis B.
Despite the existence of a preventative vaccine, HBV represents a substantial threat to public health, suggesting the need for research to develop new treatments to combat the disease. The authors review the available in vitro and in vivo models, including recently developed transgenic and chimeric mouse models.
Guha
Chandan
C
Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY, USA.
Mohan
Sankar
S
Roy-Chowdhury
Namita
N
Roy-Chowdhury
Jayanta
J
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D004195:Disease Models, Animal; D004372:Ducks; D006509:Hepatitis B; D006515:Hepatitis B virus / Q000502:physiology*; D008322:Mammals; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D019076:Transgenes / Q000235:genetics