title: [Relapsing nephrotic syndrome in a diabetic patient with minimal change].
abstract: Although nondiabetic nephropathies are common among type 2 diabetic patients, very few cases of minimal change nephrotic syndrome have been reported in diabetic patients. We describe a type 2 diabetic patient that rapidly developed a nephrotic syndrome accompanied by a mild worsening of renal function. Proteinuria was negative one year before and no signs of diabetic retinopathy were found. Renal biopsy established the diagnosis of minimal change disease. Steroid treatment induced a complete remission of nephrotic syndrome and recovery of normal renal function. However, massive proteinuria relapsed two years later. A second cycle of steroids was followed by a disappearance of proteinuria, but a third bout of nephrotic syndrome was observed 6 months later. An 8-weeks cycle of steroids plus chlorambucil induced a complete and persistent remission. Throughout a five-year follow up, no relapse of the nephrotic syndrome was observed and microalbuminuria is negative.
authors.affiliation: Servicio de Nefrología, Hospital 12 de Octubre, Madrid.
authors.forename: J A
authors.initials: JA
authors.lastname: García Donaire
authors.forename: M I
authors.initials: MI
authors.lastname: Manzanera
authors.forename: M O
authors.initials: MO
authors.lastname: Valentín
authors.forename: B
authors.initials: B
authors.lastname: Espejo
authors.forename: E
authors.initials: E
authors.lastname: Gutiérrez Martínez
authors.forename: M
authors.initials: M
authors.lastname: Praga
mesh_terms: D002699:Chlorambucil / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000175:diagnosis; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000175:diagnosis; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000652:urine; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria / Q000209:etiology; D012008:Recurrence
chemical_list: D002699:Chlorambucil; D011241:Prednisone