title: Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma.
abstract: Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trélat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.
authors.affiliation: Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, and Surgical Pathology Section, University of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pentenero
authors.forename: M
authors.initials: M
authors.lastname: Carrozzo
authors.forename: M
authors.initials: M
authors.lastname: Pagano
authors.forename: S
authors.initials: S
authors.lastname: Gandolfo
mesh_terms: D000052:Acanthosis Nigricans / Q000209:etiology*; D000230:Adenocarcinoma / Q000150:complications* / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017809:Fatal Outcome; D005743:Gastrectomy; D006801:Humans; D017492:Keratosis, Seborrheic / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D013274:Stomach Neoplasms / Q000150:complications* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents