title: Matching coronary blood flow to myocardial oxygen consumption.
abstract: At rest the myocardium extracts approximately 75% of the oxygen delivered by coronary blood flow. Thus there is little extraction reserve when myocardial oxygen consumption is augmented severalfold during exercise. There are local metabolic feedback and sympathetic feedforward control mechanisms that match coronary blood flow to myocardial oxygen consumption. Despite intensive research the local feedback control mechanism remains unknown. Physiological local metabolic control is not due to adenosine, ATP-dependent K(+) channels, nitric oxide, prostaglandins, or inhibition of endothelin. Adenosine and ATP-dependent K(+) channels are involved in pathophysiological ischemic or hypoxic coronary dilation and myocardial protection during ischemia. Sympathetic beta-adrenoceptor-mediated feedforward arteriolar vasodilation contributes approximately 25% of the increase in coronary blood flow during exercise. Sympathetic alpha-adrenoceptor-mediated vasoconstriction in medium and large coronary arteries during exercise helps maintain blood flow to the vulnerable subendocardium when cardiac contractility, heart rate, and myocardial oxygen consumption are high. In conclusion, several potential mediators of local metabolic control of the coronary circulation have been evaluated without success. More research is needed.
authors.affiliation: Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195-7290, USA.
authors.forename: Johnathan D
authors.initials: JD
authors.lastname: Tune
authors.forename: Mark W
authors.initials: MW
authors.lastname: Gorman
authors.forename: Eric O
authors.initials: EO
authors.lastname: Feigl
mesh_terms: D000241:Adenosine / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001685:Biological Factors / Q000502:physiology; D002245:Carbon Dioxide / Q000378:metabolism; D003326:Coronary Circulation / Q000502:physiology*; D016232:Endothelins / Q000502:physiology; D006321:Heart / Q000294:innervation; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology*; D015221:Potassium Channels; D011453:Prostaglandins / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D001685:Biological Factors; D016232:Endothelins; D008565:Membrane Proteins; D015221:Potassium Channels; D011453:Prostaglandins; C067410:endothelium-dependent hyperpolarization factor; C117780:mitochondrial K(ATP) channel; D002245:Carbon Dioxide; D009569:Nitric Oxide; D000241:Adenosine