[Effect of carboxyperitoneum on duration of the action of some non-depolarizing muscle relaxants].
Changing pharmacokinetics of muscle relaxants with the organ-dependent metabolism (pipecuronium), which is related with the effect exerted by carboxyperitoneum on the patient-body temperature hemostasis and on the renal function are under discussion in the paper. It was demonstrated that carboxyperitoneum affects independently the decreasing body temperature and prolonged effect duration of pipecuronium. The conclusion is that the use of muscle relaxants with the prevailing organ-dependent elimination (atracurium and cysatracurium) is more preferable versus pipecuronium in laparoscopic surgery.
Golovkin
A S
AS
Mizikov
V M
VM
Stamov
V I
VI
D000328:Adult; D000368:Aged; D001831:Body Temperature / Q000187:drug effects*; D002245:Carbon Dioxide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics*; D011028:Pneumoperitoneum, Artificial / Q000379:methods*; D013997:Time Factors
D003473:Neuromuscular Nondepolarizing Agents; D002245:Carbon Dioxide