title: The pH-dependence of preferential solvation as studied by intermolecular homo- and heteronuclear NOE measurements of adenosine in water-trifluoroethanol mixtures.
abstract: A study of the state of solvation of the adenine ring in adenosine and adenosine 5'-monophosphate disodium salt in water and in a (7.5:2.5) water-TFE mixture has been carried out by measurement of homo- and heteronuclear intermolecular NOE enhancements between water or TFE and the aromatic protons of these compounds. The results give evidence of site specificity in solute-solvent interaction for both solvent systems and preferential solvation of the solute by TFE in the water-TFE mixture. Significant pH dependence of these interactions has been discovered.
authors.affiliation: Institute of Analytical Chemistry, University of Leipzig, Linnéstr. 3, 04103 Leipzig, Germany.
authors.forename: Manuel
authors.initials: M
authors.lastname: Angulo
authors.forename: Stefan
authors.initials: S
authors.lastname: Berger
mesh_terms: D000241:Adenosine / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D012997:Solvents / Q000737:chemistry*; D014270:Trifluoroethanol / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D012997:Solvents; D014867:Water; D014270:Trifluoroethanol; D000241:Adenosine