title: Fractional quantitative computed tomography for bone mineral density evaluation: accuracy, precision, and comparison to quantitative computed tomography.
abstract: OBJECTIVE
  To evaluate bone mineral density considering its distribution, fractional quantitative computed tomography (fQCT) was designed and verified.
  
  
  METHODS
  Quantitative computed tomography (QCT) was performed at 64 areas in 10 swine long bones. Fractional quantitative computed tomography was measured at the identical areas as the proportion of pixels showing a bone density higher than 130 mg/mL equivalent. All target areas were extracted and incinerated to measure apparent ash bone density. Based on standard references, the accuracy and precision of fQCT were evaluated and the results were compared with conventional QCT results.
  
  
  RESULTS
  The correlation coefficient between fQCT and apparent ash bone density was 0.843 (P < 0.0001). The fQCT showed good correlation with volume fraction (r = 0.88, P < 0.0001). The coefficient of variation of fQCT was 0.42%. The fQCT revealed higher accuracy and precision than the results of QCT.
  
  
  CONCLUSIONS
  Fractional quantitative computed tomography was designed and verified as a reliable method to measure bone mineral density.
authors.affiliation: Department of Diagnostic Radiology, Kyungpook National University, Daegu, Republic of Korea. jonglee@knu.ac.kr
authors.forename: Jongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Hong In
authors.initials: HI
authors.lastname: Shin
authors.forename: Shin Yoon
authors.initials: SY
authors.lastname: Kim
mesh_terms: D000818:Animals; D015519:Bone Density / Q000502:physiology*; D001853:Bone Marrow / Q000737:chemistry; D001842:Bone and Bones / Q000737:chemistry; D003720:Densitometry / Q000379:methods; D008903:Minerals / Q000032:analysis; D019047:Phantoms, Imaging; D013552:Swine; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D008903:Minerals; C028705:bone ash