title: Age-dependence of lipid parameters in the general population and vegetarians.
abstract: Age-dependent changes of lipid metabolism may arise both as a result of mechanisms of biological ageing and factors influencing age-dependent changes. To study possible influences of nutrition and life-style of vegetarians on age-dependence of lipid parameters, subjects of general population were compared with vegetarians. In the frame of population-based lipid screening projects in the city of Leipzig/Germany (Lipid Study Leipzig, LSL) 10 550 subjects (3,816 men and 6,734 women, age 18-99 years) of general population were compared with 417 vegetarians (vegans, lacto-vegetarians, lacto-ovo-vegetarians, 148 men and 269 women, age 18-93 years). Most of the vegetarians included in the study were members of the German Society of Vegetarians. The study program included capillary blood cholesterol measurements and the determination of high-density lipoprotein (HDL)-cholesterol, the measurement of other cardiovascular risk factors and the evaluation of dietary and life-style factors. Evaluation of cardiovascular risk profile within LSL was connected with individual consultation. The mean total cholesterol and non-HDL-cholesterol level and the total: HDL-cholesterol ratio showed the expected age-dependence, with maximum values within the decade 60-70 years. Vegetarians showed lower total and non-HDL-cholesterol levels in comparison with the general population. Furthermore, the age-dependent increase of these parameters is less pronounced under the conditions of vegetarian nutrition and life-style. Especially in young adulthood a significant difference is observed. Thus, the results of the present study reveal the role of nutritional and life-style factors that determine the lipid profile on a population basis and suggest that the known age-dependent rise of the level of atherogenic plasma lipoproteins is partly preventable.
authors.affiliation: Laboratoriumsmedizin Klinische Chemie und Molekulare Diagnostik, Universitätsklinikum Leipzig, Liebigstrasse 27, 04103 Leipzig, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Richter
authors.forename: F
authors.initials: F
authors.lastname: Rassoul
authors.forename: B
authors.initials: B
authors.lastname: Hentschel
authors.forename: K
authors.initials: K
authors.lastname: Kothe
authors.forename: M
authors.initials: M
authors.lastname: Krobara
authors.forename: R
authors.initials: R
authors.lastname: Unger
authors.forename: K
authors.initials: K
authors.lastname: Purschwitz
authors.forename: W
authors.initials: W
authors.lastname: Rotzsch
authors.forename: J
authors.initials: J
authors.lastname: Thiery
authors.forename: K
authors.initials: K
authors.lastname: Muradian
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000453:epidemiology*; D014676:Diet, Vegetarian / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D017678:Sex Distribution
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids; D002784:Cholesterol