Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity.
Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction of methyl anilinosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 microM.
Reddy
Natala Srinivasa
NS
Fels Institute for Cancer Research, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, USA.
Mallireddigari
Muralidhar Reddy
MR
Cosenza
Stephen
S
Gumireddy
Kiranmai
K
Bell
Stanley C
SC
Reddy
E Premkumar
EP
Reddy
M V Ramana
MV
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D003374:Coumarins / Q000138:chemical synthesis / Q000633:toxicity; D006801:Humans; D020014:K562 Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
D000970:Antineoplastic Agents; D003374:Coumarins; D013449:Sulfonamides