[Successful treatment of endometrial carcinoma associated with lung metastasis by paclitaxel and carboplatin chemotherapy].
BACKGROUND
Prognosis of patients with advanced endometrial cancer accompanied by distant metastases is poor. Moreover, there is no established therapy for this cancer.


METHODS
We treated a 32-year-old woman with endometrial cancer with multiple lung metastases (pT4N0M1). In August 2001, this patient presented with a complaint of abnormal genital bleeding. Endometrial cytology and histology revealed endometrial carcinoma, and chest XP and CT scan detected multiple lung metastases. MRI indicated invasion to the uterine cervix. Therefore, radical hysterectomy with pelvic lymph node dissection was performed. Postoperatively, this patient underwent TJ chemotherapy (paclitaxel 300 mg/body over 3 h, carboplatin 600 mg/body, area under the curve (AUC 5). A total of 9 courses of the regimen were given. Multiple lung shadows on chest XP and computed tomography (CT) were reduced in number and size after 2 courses of TJ chemotherapy. The multiple lung metastases either disappeared or remained as scars after 6 courses. There has been no evidence of recurrence for 20 months after the chemotherapy.


CONCLUSIONS
TJ chemotherapy is considered effective as a postoperative chemotherapy in patients with endometrial cancer with multiple lung metastases.
Tohya
Toshimitsu
T
Dept. of Obstetrics, Kumamoto Rosai Hospital.
Onoda
Chikashi
C
Yoshimura
Toshihiro
T
Kagami
Teruo
T
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018269:Carcinoma, Endometrioid / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008175:Lung Neoplasms / Q000556:secondary*; D008197:Lymph Node Excision; D017239:Paclitaxel / Q000008:administration & dosage; D010388:Pelvis; D011182:Postoperative Care; D011379:Prognosis
D016190:Carboplatin; D017239:Paclitaxel