title: TiA1 in advanced-stage classical Hodgkin's lymphoma: no prognostic impact for positive tumour cells or number of cytotoxic cells.
abstract: No reliable marker still exists for predicting those patients with Hodgkin's lymphoma (HL) who may experience a fatal outcome. Among the factors tested in the literature, it has been suggested that the number of activated cytotoxic T cells may represent a prognostic marker in HL. In 244 samples from patients with stage-IIIB/IV HL issued from the GELA H89 trial, we have analysed TiA1 expression on Reed Sternberg (RS) cells as well as the percentage of positive reactive lymphocytes. There were 34 cases (13.7%) that showed TiA1 expression on tumour cells; whereas, in 32 cases (13.1%), TiA1-positive reactive lymphocytes represented more than 30% of the reactive lymphocytes. LMP-1 was found co-expressed with TiA1 in 10 of the 22 positive cases tested. Our study confirms that a subset of classical HL expresses cytotoxic proteins, with occasional co-expression of CD20. In stage-IIIB/IV disease, neither TiA1 expression by RS cells nor a high percentage of TiA1-positive reactive lymphocytes have a prognostic impact on outcome.
authors.affiliation: Service Central d'Anatomie et de Cytologie Pathologiques, Hotel-Dieu 1, Place du Parvis Notre Dame, 75181, Paris Cedex 04, France. sophie.camilleri-broet@htd.ap-hop-paris.fr
authors.forename: Sophie
authors.initials: S
authors.lastname: Camilleri-Broët
authors.forename: Christophe
authors.initials: C
authors.lastname: Fermé
authors.forename: Françoise
authors.initials: F
authors.lastname: Berger
authors.forename: Eric
authors.initials: E
authors.lastname: Lepage
authors.forename: Serge
authors.initials: S
authors.lastname: Bain
authors.forename: Josette
authors.initials: J
authors.lastname: Brière
authors.forename: Béatrice
authors.initials: B
authors.lastname: Marmey
authors.forename: Philippe
authors.initials: P
authors.lastname: Gaulard
authors.forename: Josée
authors.initials: J
authors.lastname: Audouin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006689:Hodgkin Disease / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D039102:Poly(A)-Binding Proteins; D011379:Prognosis; D011506:Proteins / Q000032:analysis*; D016601:RNA-Binding Proteins; D016539:Reed-Sternberg Cells / Q000737:chemistry; D000074019:T-Cell Intracellular Antigen-1
chemical_list: D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human