[Participation of the inhibitory mechanisms in the gastric hypersecretion caused by overproduction of glucocorticoids].
Semichronic experiments on rats with gastric fistula discovered that subcutaneous glucocorticoid prednisolone attenuates adrenergic (adrenalin) and M-cholinoreceptor (gastrocepin) inhibition of basal gastric secretion. This enhances the secretion in the course of the inhibitory process.
Trefilov
A B
AB
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D005938:Glucocorticoids / Q000378:metabolism* / Q000494:pharmacology; D010890:Pirenzepine / Q000494:pharmacology; D011239:Prednisolone / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism; D013270:Stomach / Q000187:drug effects
D005938:Glucocorticoids; D011976:Receptors, Muscarinic; D010890:Pirenzepine; D011239:Prednisolone; D004837:Epinephrine