Antioxidant and nitric oxide synthase activation properties of Auricularia auricula.
In vitro evaluation of antioxidant activities of Auricularia auricula showed significant inhibition of lipid peroxidation, and potent hydroxyl radical scavenging activity when compared with standard drug catechin. IC5o value of crude, boiled and ethanolic extracts of A. auricula represented 403, 510, and 373 microg/ml respectively in case of hydroxyl radical scavenging activity and 310, 572 and 398 microg/ml respectively in case of lipid peroxidation. Furthermore, crude, boiled and ethanolic extracts also increase significantly nitric oxide production (664, 191 and 850 pmole/mg dry wt/hr respectively) over the control. The present results revealed that A. auricula had potential therapeutic use.
Acharya
Krishnendu
K
Biotechnology Research Laboratory, Post Graduate Department of Botany, Darjeeling Government College, Darjeeling 734 101, India. krishnendua@rediffmail.com
Samui
Krishnendu
K
Rai
Manjula
M
Dutta
Bani Brata
BB
Acharya
Rupa
R
D000363:Agaricales / Q000201:enzymology*; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D004789:Enzyme Activation; D004912:Erythrocytes / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D017665:Hydroxyl Radical; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D013053:Spectrophotometry; D013481:Superoxides / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D013481:Superoxides; D017665:Hydroxyl Radical; D000431:Ethanol; D019001:Nitric Oxide Synthase