[GIP receptor knockout mice].
Gastric inhibitory polypeptide(GIP) is a gastrointestinal peptide hormone, which is secreted from duodenal endocrine K cells after absorption of glucose or fat. It is well known as an incretin. To determine the further role of GIP in vivo, we generated GIP receptor-knockout mice. The mice showed higher blood glucose levels with impaired initial insulin response after oral glucose load. Even after high-fat diet, knockout mice lack compensatory insulin secretion, and showed no hyper-insulinemia. Moreover, knockout mice fed a high-fat diet were clearly protected from both the obesity and the insulin resistance. Therefore, GIP directly links glucose tolerance and over-nutrition to obesity and it is a potential target for the treatment for the metabolic syndrome.
Naitoh
Rei
R
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine.
Tsukiyama
Katsushi
K
Yamada
Yuichiro
Y
D000818:Animals; D004195:Disease Models, Animal; D005749:Gastric Inhibitory Polypeptide / Q000172:deficiency*; D024821:Metabolic Syndrome / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D010446:Peptide Fragments / Q000172:deficiency*
D010446:Peptide Fragments; C049962:gastric inhibitory polypeptide (1-39); D005749:Gastric Inhibitory Polypeptide