title: Soluble gas exchange in the pulmonary airways of sheep.
abstract: We studied the airway gas exchange properties of five inert gases with different blood solubilities in the lungs of anesthetized sheep. Animals were ventilated through a bifurcated endobronchial tube to allow independent ventilation and collection of exhaled gases from each lung. An aortic pouch at the origin of the bronchial artery was created to control perfusion and enable infusion of a solution of inert gases into the bronchial circulation. Occlusion of the left pulmonary artery prevented pulmonary perfusion of that lung so that gas exchange occurred predominantly via the bronchial circulation. Excretion from the bronchial circulation (defined as the partial pressure of gas in exhaled gas divided by the partial pressure of gas in bronchial arterial blood) increased with increasing gas solubility (ranging from a mean of 4.2 x 10(-5) for SF6 to 4.8 x 10(-2) for ether) and increasing bronchial blood flow. Excretion was inversely affected by molecular weight (MW), demonstrating a dependence on diffusion. Excretions of the higher MW gases, halothane (MW = 194) and SF6 (MW = 146), were depressed relative to excretion of the lower MW gases ethane, cyclopropane, and ether (MW = 30, 42, 74, respectively). All results were consistent with previous studies of gas exchange in the isolated in situ trachea.
authors.affiliation: Department of Medicine, University of Washington, Seattle 98195-6522, USA.
authors.forename: Carmel
authors.initials: C
authors.lastname: Schimmel
authors.forename: Susan L
authors.initials: SL
authors.lastname: Bernard
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Anderson
authors.forename: Nayak L
authors.initials: NL
authors.lastname: Polissar
authors.forename: S
authors.initials: S
authors.lastname: Lakshminarayan
authors.forename: Michael P
authors.initials: MP
authors.lastname: Hlastala
mesh_terms: D000818:Animals; D001980:Bronchi / Q000098:blood supply / Q000502:physiology*; D001981:Bronchial Arteries; D004058:Diffusion; D045853:Exhalation; D008954:Models, Biological; D008970:Molecular Weight; D005741:Noble Gases / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry; D010313:Partial Pressure; D011659:Pulmonary Gas Exchange; D012039:Regional Blood Flow; D012756:Sheep; D012995:Solubility
chemical_list: D005741:Noble Gases