title: Submerged cultivation of medicinal mushrooms for production of valuable bioactive metabolites.
abstract: Mushrooms are abundant sources of a wide range of useful natural products. Nowadays, commercial mushroom products are from mushrooms collected from field cultivation, which is a time-consuming and labor-intensive process. Submerged cultivation of mushrooms has significant industrial potential, but its success on a commercial scale depends on cost compared with existing technology. Increasing product yields and development of novel production systems that address the problems associated with this new technology will certainly facilitate expansion. This article outlines the major valuable metabolites produced by mushroom cultivation and advances in submerged culture of mushrooms, taking Ganoderma lucidum, a popular folk and an oriental medicine used to treat many diseases, as a typical example. Our latest data on mushroom cultivation for efficient production of bioactive ganoderic acids and Ganoderma polysaccharides in bioreactors are presented.
authors.affiliation: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. jjzhong@ecust.edu.cn
authors.forename: Jian-Jiang
authors.initials: JJ
authors.lastname: Zhong
authors.forename: Ya-Jie
authors.initials: YJ
authors.lastname: Tang
mesh_terms: D000363:Agaricales / Q000254:growth & development / Q000378:metabolism; D001685:Biological Factors / Q000302:isolation & purification* / Q000378:metabolism* / Q000627:therapeutic use; D019149:Bioreactors; D018929:Cell Culture Techniques / Q000379:methods*; D003198:Computer Simulation; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000378:metabolism / Q000627:therapeutic use; D008954:Models, Biological; D010101:Oxygen Consumption; D020940:Reishi / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D001685:Biological Factors; D004365:Drugs, Chinese Herbal