Acute hepatic failure in swine: hepatectomy versus vascular occlusion.
The two most promising surgical animal models of fulminant hepatic failure (FHF) for investigation of the safety and efficacy of new treatment modalities were analyzed in a porcine study. Animals underwent total hepatectomy or devascularization of hepatic artery and portal vein followed by portocaval (PC) shunting. Survival time, technical feasibility, safety, and reproducibility of the models were investigated. Devascularization seems to be most useful for studying the development and treatment of FHF caused by ischemia and its side effects. Total hepatectomy is superior for investigation of the anhepatic status and treatment of FHF by bioartifical liver support systems.
Frühauf
Nils R
NR
Department of General and Transplantation Surgery, University of Essen, Essen, Germany.
Oldhafer
Karl J
KJ
Westermann
Stephanie
S
Sotiropoulos
Georgios C
GC
Kaiser
Gernot M
GM
D000818:Animals; D004195:Disease Models, Animal; D005240:Feasibility Studies; D005260:Female; D006498:Hepatectomy; D006499:Hepatic Artery / Q000601:surgery; D008026:Ligation; D008099:Liver / Q000098:blood supply / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000503:physiopathology*; D023421:Models, Animal; D011169:Portal Vein / Q000601:surgery; D013552:Swine; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000379:methods*