title: Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study.
abstract: We assessed the relationships between chronic arsenic (As) exposure, human papilloma virus (HPV) contact and non-melanoma skin cancer (NMSC) by means of a dermatology clinic-based case-control study (42 cases and 48 controls) in Region Lagunera, Mexico, where chronic As poisoning is endemic. Exposure was determined through detailed history of residence in the As-contaminated area and measurement of As levels in drinking water and urine. We used a consensus epitope from the central region of L1 protein of the HPV family to determine antibodies against HPV. A history of As exposure and HPV seropositivity were associated with increased NMSC risks. A history of exposure to high levels of As increased the risk for NMSC (OR = 4.53; P = 0.11) in the group of seronegative HPV patients. A positive response to HPV significantly increased the OR for NMSC to 9.04 (P = 0.01) when history showed exposure to low levels of As. Interestingly, the OR was significantly increased to 16.5 (P = 0.001) when both exposure to high levels of As and HPV seropositivity were present. In addition, the presence of NMSC increased the OR (5.45; P = 0.03) for a positive response to HPV when history showed exposure to low levels of As, but the OR was increased to 8.0 (P = 0.005) in the cases with high exposure levels. Thus, HPV infection could constitute an additional risk factor for NMSC development in humans chronically exposed to As. However, further studies with additional populations are needed to determine the interaction between HPV and As exposure in NMSC.
authors.affiliation: Sección de Toxicología, CINVESTAV, PO Box 14-740, Av. Instituto Politécnico Nacional # 2508, Col. San Pedro Zacatenco, Delegación Gustavo A. Madero, 07300 Mexico DF, Mexico.
authors.forename: J Alberto
authors.initials: JA
authors.lastname: Rosales-Castillo
authors.forename: Leonor C
authors.initials: LC
authors.lastname: Acosta-Saavedra
authors.forename: Rosantina
authors.initials: R
authors.lastname: Torres
authors.forename: Jesús
authors.initials: J
authors.lastname: Ochoa-Fierro
authors.forename: Víctor H
authors.initials: VH
authors.lastname: Borja-Aburto
authors.forename: Lizbeth
authors.initials: L
authors.lastname: Lopez-Carrillo
authors.forename: Gonzalo G
authors.initials: GG
authors.lastname: Garcia-Vargas
authors.forename: Georgina B
authors.initials: GB
authors.lastname: Gurrola
authors.forename: Mariano E
authors.initials: ME
authors.lastname: Cebrian
authors.forename: Emma S
authors.initials: ES
authors.lastname: Calderón-Aranda
mesh_terms: D000368:Aged; D000554:Ambulatory Care Facilities; D020261:Arsenic Poisoning / Q000097:blood / Q000150:complications* / Q000652:urine; D016022:Case-Control Studies; D003880:Dermatology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D018604:Epitope Mapping; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008800:Mexico; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D010865:Pilot Projects; D012111:Residence Characteristics; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000821:virology*; D013054:Spectrophotometry, Atomic; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D014881:Water Supply
chemical_list: D014874:Water Pollutants, Chemical