Zinc-proline catalyzed pathway for the formation of sugars.
Zn-proline catalyzes the aldolisation of unprotected glycolaldehyde in water to give tetroses and hexoses; threose (33% of the product mixture) was formed with 10% enantiomeric excess of the D-isomer.
Kofoed
Jacob
J
Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland.
Machuqueiro
Miguel
M
Reymond
Jean-Louis
JL
Darbre
Tamis
T
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry*; D002241:Carbohydrates / Q000138:chemical synthesis*; D002384:Catalysis; D006601:Hexoses / Q000138:chemical synthesis; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism; D013780:Tetroses / Q000138:chemical synthesis; D015032:Zinc / Q000737:chemistry*
D002241:Carbohydrates; D006601:Hexoses; D012996:Solutions; D013780:Tetroses; D011392:Proline; D000079:Acetaldehyde; D015032:Zinc; C010972:glycolaldehyde