Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis.
Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.
Hurd
Elizabeth A
EA
Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109-0617, USA.
Domino
Steven E
SE
D000818:Animals; D002181:Candidiasis, Vulvovaginal / Q000201:enzymology*; D005260:Female; D005647:Fucosyltransferases / Q000172:deficiency / Q000235:genetics*; D017930:Genes, Reporter; D020022:Genetic Predisposition to Disease; D006023:Glycoproteins / Q000037:antagonists & inhibitors; D051379:Mice; D014621:Vagina / Q000382:microbiology*; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D005647:Fucosyltransferases; D006023:Glycoproteins; D000097631:Galactoside 2-alpha-L-fucosyltransferase