CT colonography: feasibility of substantial dose reduction--comparison of medium to very low doses in identical patients.
In a feasibility study, the authors compared polyp detection and interobserver variability at computed tomographic (CT) colonography in 15 patients with doses ranging from medium to very low (12.00-0.05 mSv). At levels down to 2% of the medium dose, the mean detection of polyps 5 mm or larger remained at least 74%, while the number of false-positive results decreased and the interobserver agreement remained constant. Initial observations indicate that it is feasible to reduce the radiation dose required for CT colonography. Further studies are needed, however, to investigate the clinical value of very low-dose CT colonography.
van Gelder
Rogier E
RE
Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. r.e.vangelder@amc.uva.nl
Venema
Henk W
HW
Florie
Jasper
J
Nio
C Yung
CY
Serlie
Iwo W O
IW
Schutter
Michiel P
MP
van Rijn
Jeroen C
JC
Vos
Frans M
FM
Glas
Afina S
AS
Bossuyt
Patrick M M
PM
Bartelsman
Joep F W
JF
Laméris
Johan S
JS
Stoker
Jaap
J
D000328:Adult; D000368:Aged; D016477:Artifacts; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging*; D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005189:False Positive Reactions; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011874:Radiometry / Q000706:statistics & numerical data*; D012307:Risk Factors; D012680:Sensitivity and Specificity