title: Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus.
abstract: A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus.
authors.affiliation: Elanco Animal Health Research and Development, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140-0708, USA. gonzalez_isabel_c@lilly.com
authors.forename: Isabel C
authors.initials: IC
authors.lastname: González
authors.forename: Leon N
authors.initials: LN
authors.lastname: Davis
authors.forename: Charles K
authors.initials: CK
authors.lastname: Smith
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects*; D007700:Kinetics; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000871:Anthelmintics; D013876:Thiophenes