title: Deficit of preparatory attention in frontotemporal dementia.
abstract: We studied preparatory attention in patients suffering from frontotemporal dementia in the beginning stages of the disease, using an experimental test developed by LaBerge, Auclair, and Siéroff (2000). In this experimental test, a distracter can appear while subjects have to prepare to respond to a simple target. The probability that a distracter can appear in a trial is varied across three blocks. Normal controls show an increase of response times to targets (slope) as a function of the distracter probability, preparatory attention to the target is reduced by the increase of the distracter probability. Patients suffering from frontotemporal dementia show a slope of response times which is more than twice as large as the slope obtained by their matched controls. Such an abnormal increase of response times to targets is interpreted as a deficit in preparatory attention. Patients also show more omissions than controls. We suggest that this deficit in preparatory attention is related to the frontal lesion presented by the patients and can result in higher distractibility, a symptom frequently encountered in these patients.
authors.affiliation: Laboratoire de Psychologie Expérimentale, CNRS, Université Paris René Descartes, Paris V, France. sieroff@psycho.univ-paris5.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Siéroff
authors.forename: Ambre
authors.initials: A
authors.lastname: Piquard
authors.forename: Laurent
authors.initials: L
authors.lastname: Auclair
authors.forename: Lucette
authors.initials: L
authors.lastname: Lacomblez
authors.forename: Christian
authors.initials: C
authors.lastname: Derouesné
authors.forename: David
authors.initials: D
authors.lastname: Laberge
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D003704:Dementia / Q000503:physiopathology*; D005260:Female; D005364:Field Dependence-Independence; D006801:Humans; D008297:Male; D008875:Middle Aged; D011337:Probability Learning; D011930:Reaction Time / Q000502:physiology*; D012016:Reference Values