[Pathophysiological evolution of coronary (ischemic) heart disease: ischemia, dystrophy, necrosis, sclerosis].
Pathophysiological evolution of coronary (ischemic) heart disease in the following order: ischemia--dystrophy--necrosis (infarction)--myocardial sclerosis is postulated. The authors give clinical, instrumental, laboratory characteristics of ischemia, focal dystrophy with 2 types of manifestations: the hibernating ("silent") myocardium and the stunned myocardium (focal dysfunction preserves after revascularization although cardiomyocytes remain alive). The following stages are small and large myocardial infarction, next are cardioscleroses, such as focal postinfarct (postnecrotic) and small focal atherosclerotic (microcirculatory, diffuse postdystrophic).
Zakharov
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D000368:Aged; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D009336:Necrosis