[Renal complications of non-steroidal anti-inflammatories].
BACKGROUND
Non-steroidal antiinflammatory drugs (NSAIDs) are known to have adverse effects on kidney function. Situations with stimulated renin-angiotensin system (RAS) like volume depletion or preexisting chronic renal failure predispose to acute renal failure (ARF) via inhibition of prostaglandin synthesis by NSAIDs. To date NSAIDs are frequently used as antipyretic drugs even in situations predisposing to ARF.


METHODS
Within 20 months seven children presenting with diarrhea and/or vomiting and fever were treated with therapeutic doses (11.5-32 mg/kg per day) of ibuprofen for 1-3 days before developing ARF. Maximum plasma creatinine levels were 180-650 pmol/l. One patient required emergency dialysis for hyperkalemia, uremia, and hyperphosphatemia. After cessation of NSAID treatment and rehydration all patients recovered completely with a normalized creatinine level after 3-9 days. Once the acute phase is controlled long-term outcome is excellent.


CONCLUSIONS
NSAIDs are potentially dangerous in situations with, even moderate, volume depletion.
Ulinski
T
T
Service de néphrologie pédiatrique hôpital d'enfants Armand-Trousseau, Paris, France. timulinski@hotmail.com
Bensman
A
A
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D003967:Diarrhea / Q000188:drug therapy; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology; D007052:Ibuprofen / Q000009:adverse effects; D007674:Kidney Diseases / Q000209:etiology*; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012307:Risk Factors; D014882:Water-Electrolyte Balance
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; D003404:Creatinine; D007052:Ibuprofen