Prognostic value of tryptophan load test followed by serum kynurenine determination. Its comparison with pyridoxal-5-phosphate, kynurenine, homocysteine and neopterin amounts.
Tryptophan load test followed by serum kynurenine determination at fasting state and after L-tryptophan loading, as well as serum pyridoxal-5-phosphate (P-5-P), homocysteine and neopterin concentrations at fasting state have been examined in 30 healthy individuals and 87 patients with coronary heart disease (CHD), verified by coronary angiography. Received results have shown that low serum P-5-P concentration as well as P-5-P deficiency identified by tryptophan load test have been found in 78% of CHD patients, while increased homocysteine concentration above 15 micromol/L in 31.8%, and elevated neopterin concentration above 8.7 nmol/L in 32.1% of cases. It allows to conclude that a lot of CHD patients have P-5-P deficiency. Moreover P-5-P deficiency is an earlier indicator of CHD than increased homocysteine level above 15 micromol/L. Elevated serum neopterin concentration above 8.7 nmol/L may be a marker of coronary disease activity rather than a marker of the presence of CHD.
Rudzite
Vera
V
Latvian Institute of Cardiology, Laboratory of Biochemistry, Pilsonu Street 13, LV 1002 Riga, Latvia.
Fuchs
Dietmar
D
Kalnins
Uldis
U
Jurika
Edite
E
Silava
Anita
A
Erglis
Andrejs
A
Trusinskis
Karlis
K
Jegere
Sanda
S
D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007737:Kynurenine / Q000097:blood*; D019798:Neopterin / Q000097:blood*; D011379:Prognosis; D011732:Pyridoxal Phosphate / Q000097:blood*; D014364:Tryptophan / Q000008:administration & dosage
D015415:Biomarkers; D006710:Homocysteine; D007737:Kynurenine; D011732:Pyridoxal Phosphate; D019798:Neopterin; D014364:Tryptophan