Successful treatment with succinate in a patient with MELAS.
We present a case report of a 27-year-old man with MELAS, who presented with general convulsions and left flaccid hemiparesis. Anticonvulsant drugs failed to achieve complete control of his convulsions. A good response to oral administration of succinate has been maintained for more than 30 months, with no recurrence of any stroke-like episode. Succinate therapy may have potential for treatment of uncontrolled convulsive MELAS patients.
Oguro
Hiroaki
H
Third Department of Internal Medicine, Shimane University School of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501.
Iijima
Kenichi
K
Takahashi
Kazuo
K
Nagai
Atsushi
A
Bokura
Hirokazu
H
Yamaguchi
Shuhei
S
Kobayashi
Shotai
S
D000284:Administration, Oral; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004569:Electroencephalography; D005500:Follow-Up Studies; D006801:Humans; D017241:MELAS Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D012720:Severity of Illness Index; D019802:Succinic Acid / Q000008:administration & dosage*; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome
D019802:Succinic Acid