title: A morphometric study of nucleolar organiser regions in cervical intraepithelial neoplasia.
abstract: The study sought a correlation between the number of AgNOR granules and the degree of cervical intraepithelial neoplasia (CIN). Thirty-five sections (5 normal, 10 CIN1, 10 CIN2 and 10 CIN3) were subjected to retrospective analysis. The percentage of cells with 1, 2, 3, 4 and more AgNORs was calculated and the number of granules per 100 cells was counted. The number of cells containing single granules decreases. However, the number increases with CIN level when the cells contain 4 and more AgNORs. The number of granules per 100 cells also increases with the degree of CIN. It can be thus concluded that the number of cells with 4 and more AgNOR granules can serve as a CIN differentiation exponent.
authors.affiliation: Department of Pathophysiology of Pregnancy, Medical University, Białystok, Poland. ster@amb.edu.pl
authors.forename: Sławomir
authors.initials: S
authors.lastname: Terlikowski
authors.forename: Janusz
authors.initials: J
authors.lastname: Dziecioł
authors.forename: Andrzej
authors.initials: A
authors.lastname: Mazurek
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sulkowski
authors.forename: Robert
authors.initials: R
authors.lastname: Boroń
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Oniszczuk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lejmanowicz
mesh_terms: D001706:Biopsy; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009697:Nucleolus Organizer Region; D012189:Retrospective Studies; D016622:Silver Staining; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000235:genetics / Q000473:pathology*