Severe neutropenia consequent to sustained-release procainamide.
A patient with reversible severe neutropenia and relative eosinophilia caused by sustained-release procainamide is described. Significant early and very late complications of therapy with procainamide preparations have been rarely described so far. The important pharmacokinetic aspects of sustained release procainamide are discussed, and the postulated mechanisms of induction of blood dyscrasias are reviewed.
Mellino
M
M
Department of Medicine, Division of Cardiology, Case Western University School of Medicine, Lutheran Medical Center, Cleveland, Ohio 44113, USA.
Hogan
J
J
Taylor
H C
HC