Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam.
The anticonvulsive effect of midazolam was compared with that of diazepam in ten dogs. Lidocaine-induced seizure waves on the electroencephalogram were used to observe the suppressive effect of the drugs. Midazolam, 0.2 mg.kg(-1), was found to possess a stronger suppressive effect against lidocaine-induced seizures than the same dose of diazepam. These two drugs showed to possess similar effects on cerebral and systemic circulations and cerebral metabolism during seizures.
Horikawa
H
H
Department of Anesthesia, Yamagata University School of Medicine, Yamagata, Japan.
Tada
T
T
Sakai
M
M
Karube
T
T
Ichiyanagi
K
K