title: Comparison of levels of matrix metalloproteinases, tissue inhibitor of metalloproteinases, interleukins, and tissue necrosis factor in carotid endarterectomy specimens from patients on versus not on statins preoperatively.
abstract: We performed an observational study on 137 patients undergoing carotid endarterectomy (CEA). Patients on statins were less likely to have had symptoms in the 4 weeks before CEA (p = 0.0049) and were less likely to have spontaneous cerebral embolization detected by transcranial Doppler (p = 0.0459). Carotid plaques retrieved at CEA from patients taking statins revealed significantly lower concentrations of matrix metalloproteinase-1 (p = 0.0176), matrix metalloproteinase-9 (p = 0.0018), and interleukin-6 (p = 0.0005).
authors.affiliation: Department of Surgery, University of Leicester, Leicester, United Kingdom.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Molloy
authors.forename: Matt M
authors.initials: MM
authors.lastname: Thompson
authors.forename: Edward C
authors.initials: EC
authors.lastname: Schwalbe
authors.forename: Peter R F
authors.initials: PR
authors.lastname: Bell
authors.forename: A Ross
authors.initials: AR
authors.lastname: Naylor
authors.forename: Ian M
authors.initials: IM
authors.lastname: Loftus
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D000069059:Atorvastatin; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D016894:Endarterectomy, Carotid; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage; D005260:Female; D000077340:Fluvastatin; D006538:Heptanoic Acids / Q000008:administration & dosage; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D007211:Indoles / Q000008:administration & dosage; D007378:Interleukins / Q000378:metabolism; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D008875:Middle Aged; D017035:Pravastatin / Q000008:administration & dosage; D011758:Pyrroles / Q000008:administration & dosage; D019821:Simvastatin / Q000008:administration & dosage; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D005229:Fatty Acids, Monounsaturated; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D007378:Interleukins; D011758:Pyrroles; D019714:Tissue Inhibitor of Metalloproteinases; D014409:Tumor Necrosis Factor-alpha; D000077340:Fluvastatin; D000069059:Atorvastatin; D019821:Simvastatin; D020782:Matrix Metalloproteinases; D017035:Pravastatin