p27 and Barrett's esophagus: a review*.
The rising prevalence of Barrett's esophagus and Barrett's associated adenocarcinoma in the Western world has stimulated increasing interest in this disease. This has resulted in a plethora of articles concerning its molecular biology, but the tumor suppressor gene, p27, has received little attention. In this article, we review the literature concerning the role of p27 in Barrett's esophagus and its malignant transformation, and we evaluate its possible role as an important clinical biomarker, as well as potential chemopreventive clinical agents aimed at substituting its antitumoral activity.
Ellis
F H
FH
Beth Israel Deaconess Medical Center, Division of Cardiothoracic Surgery, Harvard Medical School, Boston, MA 02215, USA. mjwe@rcn.com
Loda
M
M
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D000818:Animals; D001471:Barrett Esophagus / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051546:Cyclooxygenase 2; D004195:Disease Models, Animal; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D004947:Esophagus / Q000201:enzymology / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins; D051379:Mice; D009092:Mucous Membrane / Q000473:pathology; D009154:Mutation; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000502:physiology
D014408:Biomarkers, Tumor; C493961:Cdkn1b protein, mouse; C493962:Cdkn1b protein, rat; D018797:Cell Cycle Proteins; D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases