title: Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants.
abstract: Diffusion tensor imaging (DTI) was used to delineate early laminar organization of the cerebrum in two extremely premature infants imaged postnatally at estimated ages of 25 and 27 menstrual weeks. The diffusivity and anisotropy of the cortical plate, subplate zone, intermediate zone, subventricular and periventricular zones, and germinal matrix are examined. Automated segmentation of diffusion tensor images to reveal the laminar architecture of the developing human cerebrum is also demonstrated.
authors.affiliation: Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA.
authors.forename: Luis C
authors.initials: LC
authors.lastname: Maas
authors.forename: Pratik
authors.initials: P
authors.lastname: Mukherjee
authors.forename: Julio
authors.initials: J
authors.lastname: Carballido-Gamio
authors.forename: Srivathsa
authors.initials: S
authors.lastname: Veeraraghavan
authors.forename: Steven P
authors.initials: SP
authors.lastname: Miller
authors.forename: Savannah C
authors.initials: SC
authors.lastname: Partridge
authors.forename: Roland G
authors.initials: RG
authors.lastname: Henry
authors.forename: A James
authors.initials: AJ
authors.lastname: Barkovich
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Vigneron
mesh_terms: D000375:Aging; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000254:growth & development; D038524:Diffusion Magnetic Resonance Imaging; D017352:Echo-Planar Imaging; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*