title: Clinical efficacy of computerised cognitive-behavioural therapy for anxiety and depression in primary care: randomised controlled trial.
abstract: BACKGROUND
  Preliminary results have demonstrated the clinical efficacy of computerised cognitive-behavioural therapy (CBT) in the treatment of anxiety and depression in primary care.
  
  
  OBJECTIVE
  To determine, in an expanded sample, the dependence of the efficacy of this therapy upon clinical and demographic variables.
  
  
  METHODS
  A sample of 274 patients with anxiety and/or depression were randomly allocated to receive, with or without medication, computerised CBT or treatment as usual, with follow-up assessment at 6 months.
  
  
  RESULTS
  The computerised therapy improved depression, negative attributional style, work and social adjustment, without interaction with drug treatment, duration of preexisting illness or severity of existing illness. For anxiety and positive attributional style, treatment interacted with severity such that computerised therapy did better than usual treatment for more disturbed patients. Computerised therapy also led to greater satisfaction with treatment.
  
  
  CONCLUSIONS
  Computer-delivered CBT is a widely applicable treatment for anxiety and/or depression in general practice.
authors.affiliation: Centre for General Practice Integration Studies, School of Public Health and Community Medicine, University of New South Wales, Sydney, Australia. j.proudfoot@unse.edu.au
authors.forename: Judith
authors.initials: J
authors.lastname: Proudfoot
authors.forename: Clash
authors.initials: C
authors.lastname: Ryden
authors.forename: Brian
authors.initials: B
authors.lastname: Everitt
authors.forename: David A
authors.initials: DA
authors.lastname: Shapiro
authors.forename: David
authors.initials: D
authors.lastname: Goldberg
authors.forename: Anthony
authors.initials: A
authors.lastname: Mann
authors.forename: Andre
authors.initials: A
authors.lastname: Tylee
authors.forename: Isaac
authors.initials: I
authors.lastname: Marks
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Gray
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000628:therapy*; D001008:Anxiety Disorders / Q000628:therapy; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019212:Multimedia; D017060:Patient Satisfaction; D011320:Primary Health Care / Q000379:methods*; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome