Lysostaphin-coated catheters eradicate Staphylococccus aureus challenge and block surface colonization.
Lysostaphin is an endopeptidase that kills Staphylococcus aureus, a predominant organism in catheter-related infections. Lysostaphin-coated catheters prevented catheter colonization by several strains of S. aureus, and activity was maintained for at least 4 days. Prophylactic use of lysostaphin in catheters may help prevent the occurrence of catheter-related staphylococcal infections.
Shah
Anjali
A
Biosynexus, Inc., 9119 Gaither Road, Gaithersburg, MD 20877, USA.
Mond
James
J
Walsh
Scott
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002404:Catheterization; D003030:Coagulase / Q000378:metabolism; D008248:Lysostaphin / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development*; D013212:Staphylococcus epidermidis / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003030:Coagulase; D008248:Lysostaphin