Botryllamides E-H, four new tyrosine derivatives from the ascidian Botrylloides tyreum.
A specimen of the ascidian Botrylloides tyreum from Palau contained the known metabolites botryllamides A (5) and C (7) together with four new tyrosine derivatives, botryllamides E-H (1-4), the structures of which were elucidated by interpretation of spectroscopic data. The botryllamides exhibited weak cytotoxicity against the HCT-116 cell line.
Rao
M Rama
MR
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA. rmanam@nereuspharm.com
Faulkner
D John
DJ
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019029:Palau; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D014443:Tyrosine