title: Topography of the human corpus callosum using diffusion tensor tractography.
abstract: OBJECTIVE
  To evaluate the crossing fiber trajectory through the corpus callosum using distortion-corrected diffusion tensor tractography in the human brain.
  
  
  METHODS
  After correcting distortion associated with large-diffusion gradients, T2-weighted echo planar images (EPIs) acquired from 10 right-handed healthy men were coregistered into T2-weighted fast spin echo images using linear through sixth-order nonlinear, 3-dimensional, polynomial warping functions. The optimal transformation parameters were also applied to the distortion-corrected diffusion-weighted EPIs. Diffusion tensor tractography through the corpus callosum was reconstructed, employing the "1 or 2 regions of interest" method.
  
  
  RESULTS
  Compared with the lines through the genu, those through the rostrum ran more inferiorly and seemed to enter the orbital gyrus. Those lines entering posterior temporal white matter (tapetum) crossed through the ventral portion of the splenium and were clearly distinguished from lines that reached parieto-occipital white matter (forceps major).
  
  
  CONCLUSIONS
  Diffusion tensor tractography is a feasible noninvasive tool to evaluate commissural fiber trajectory.
authors.affiliation: Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. abediag-tky@umin.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Masutani
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Hidenori
authors.initials: H
authors.lastname: Yamasue
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Yamada
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Kasai
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.forename: Naoto
authors.initials: N
authors.lastname: Hayashi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Masumoto
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003337:Corpus Callosum / Q000033:anatomy & histology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D017352:Echo-Planar Imaging; D005240:Feasibility Studies; D005625:Frontal Lobe / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D008297:Male; D013702:Temporal Lobe / Q000033:anatomy & histology