[Spermatocytic seminoma. A clinicopathological and immunohistochemical study of 7 cases].
Spermatocytic seminoma is an uncommon tumor, representing less than 1% of the testicular tumors, occurring most often in old patients. We report 7 cases of this entity. The average age at presentation was 66 years. Tumors had a polymorphic appearance with small, intermediate and large cells, and "spireme" figures. They were pure, with no sarcomatous component. In all cases, the tumor was limited to the testis. In the peritumoral tissue, there was no intratubular germ cell proliferation, and no atrophic testis. Immunostaining was negative for all the classical antibodies tested (cytokeratins, PLAP, lymphoid markers), but all the cases expressed c-kit (100%). This membranous positivity was focal in 4 cases, very strong, and diffuse in the 3 others. Spermatocytic seminoma must be recognized, because its favorable evolution in absence of a sarcomatous component. Adequate treatment consists of orchidectomy alone. Positive staining for c-kit may be helpful for the diagnosis of spermatocytic seminoma.
Decaussin
Myriam
M
Service d'Anatomie et Cytologie Pathologiques, Centre Hospitalier Lyon Sud, 69495, Pierre-Bénite France. myriam.decaussin@chu-lyon.fr
Borda
Angela
A
Bouvier
Raymonde
R
Ruffion
Alain
A
David
Catherine
C
Agard
Catherine
C
Arcin
Fabienne
F
Collet
François
F
Berger
Nicole
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009919:Orchiectomy; D018239:Seminoma / Q000473:pathology* / Q000601:surgery; D013090:Spermatocytes / Q000473:pathology*; D013736:Testicular Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome