In vivo and in vitro effect of latex of Calotropis procera on gastrointestinal smooth muscles.
The present study was carried out to evaluate the effect of dry latex (DL) of Calotropis procera on smooth muscles of gastrointestinal tract. Oral administration of DL to rats (50-1000 mg/kg) produced a dose-dependent decrease in intestinal transit along with a decrease in intestinal content as compared to control group. At lower doses DL produced dose-dependent contractions of gastrointestinal smooth muscles in vitro (rabbit ileum and fundus of rat stomach) that was followed by desensitization at higher doses.
Kumar
V L
VL
Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. kumarvl198@hotmail.com
Shivkar
Y M
YM
D000284:Administration, Oral; D000818:Animals; D031107:Calotropis; D004064:Digestive System / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005769:Gastrointestinal Motility / Q000187:drug effects; D007840:Latex / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D051381:Rats; D017208:Rats, Wistar
D007840:Latex