title: Pathological evaluation of postmortem human eyes implanted with a new single-piece hydrophobic acrylic lens.
abstract: OBJECTIVE
  To report the pathological findings in 14 human cadaver eyes implanted with a single-piece AcrySof(Alcon Laboratories) posterior chamber intraocular lens (IOL).
  
  
  METHODS
  David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.
  
  
  METHODS
  Fourteen human autopsy eyes implanted with a single-piece AcrySof (SA30AL) IOL were evaluated. The eyes were sectioned at the equatorial plane, and the anterior segment containing the IOL in the capsular bag was evaluated from a posterior perspective (Miyake-Apple view) and from an anterior perspective (surgeon's view) after removal of cornea and iris. They were then processed through paraffin, sectioned, and stained with hematoxylin-eosin, periodic acid-Schiff, and Masson's trichrome and examined under light microscopy.
  
  
  RESULTS
  All IOLs had symmetric in-the-bag fixation. Slight decentration was measured in 1 eye, which also had an anterior capsule tear. Grade 1 anterior capsule opacification was present in 9 eyes. No central posterior capsule opacification or posterior capsule folds were observed in any eye. Soemmering's ring formation was observed in 5 eyes. Zonular stretch caused by different degrees of capsular bag contraction was present in 4 eyes without decentration of the IOL.
  
  
  CONCLUSIONS
  Analyses of pseudophakic cadaver eyes from the posterior (Miyake-Apple) view, complemented by microscopic analyses, proved useful in the evaluation of IOL-capsular bag interaction. These studies are more important in cases of newly introduced lens designs.
authors.affiliation: David J. Apple, MD Laboratories for Ophthalmic Devices Research, John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA.
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Izak
authors.forename: Liliana
authors.initials: L
authors.lastname: Werner
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Pandey
authors.forename: David J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D000869:Anterior Eye Segment / Q000473:pathology*; D001672:Biocompatible Materials; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D011102:Polyhydroxyethyl Methacrylate; D011474:Prosthesis Design
chemical_list: D001672:Biocompatible Materials; D011102:Polyhydroxyethyl Methacrylate