title: Value of (124)I-PET/CT in staging of patients with differentiated thyroid cancer.
abstract: The aim of this study is to evaluate the clinical significance of (124)I positron emission tomography (PET) using a combined PET/CT tomograph in patients with differentiated thyroid carcinoma and to compare the PET/CT results with (131)I whole-body scintigraphy (WBS), dedicated PET and CT alone. Twelve thyroid cancer patients were referred for diagnostic workup and entered complete clinical evaluation, including histology, cytology, thyroglobulin level, ultrasonography, fluorine-18 fluorodeoxyglucose (FDG)-PET, FDG-PET/CT and CT. Lesion-based evaluation showed a lesion delectability of 56, 87 and 100% for CT, (124)I-PET, and combined (124)I-PET/CT imaging, respectively. Lesion delectability of (131)I-WBS was 83%. We conclude that (124)I-PET/CT imaging is a promising technique to improve treatment planning in thyroid cancer. It is particularly valuable in patients suffering from advanced differentiated thyroid cancer prior to radio-iodine therapy and in patients with suspected recurrence and potential metastatic disease.
authors.affiliation: Clinic and Policlinic for Nuclear Medicine, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany. l.freudenberg@t-online.de
authors.forename: L S
authors.initials: LS
authors.lastname: Freudenberg
authors.forename: G
authors.initials: G
authors.lastname: Antoch
authors.forename: W
authors.initials: W
authors.lastname: Jentzen
authors.forename: R
authors.initials: R
authors.lastname: Pink
authors.forename: J
authors.initials: J
authors.lastname: Knust
authors.forename: R
authors.initials: R
authors.lastname: Görges
authors.forename: S P
authors.initials: SP
authors.lastname: Müller
authors.forename: A
authors.initials: A
authors.lastname: Bockisch
authors.forename: J F
authors.initials: JF
authors.lastname: Debatin
authors.forename: W
authors.initials: W
authors.lastname: Brandau
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000145:classification / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D013961:Thyroid Gland / Q000000981:diagnostic imaging*; D013964:Thyroid Neoplasms / Q000145:classification / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography
chemical_list: D007457:Iodine Radioisotopes