title: Towards dissecting nutrient metabolism in plants: a systems biology case study on sulphur metabolism.
abstract: A genomics analysis on sulphur metabolism has been conducted at the level of transcriptomics and metabolomics. The analysis of these data after applying bioinformatic tools is to reveal novel findings. The findings are discussed and the knowledge obtained from comparable analyses on sulphur metabolism and other plant nutrient genomic studies is reviewed. The analysis of the response of the transcriptome and metabolome to sulphur deprivation in the growth medium provides a tool set for the analysis of comparable genomics studies of other nutrients. The goal of this 'sulphobolomics' (i.e. sulphur genomics and metabolome analysis) approach, and of other investigations, is to describe in a holistic way the biochemical, molecular, and physiological response of a plant to nutrient starvation, here sulphate, or, more generally, to alterations and imbalances in nutrient availability. Eventually, this analysis will provide a case study for a systems biology approach.
authors.affiliation: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Department of Molecular Physiology, Am Mühlenberg 1, D-14476 Golm, Germany.
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Nikiforova
authors.forename: Bertrand
authors.initials: B
authors.lastname: Gakière
authors.forename: Stefan
authors.initials: S
authors.lastname: Kempa
authors.forename: Monika
authors.initials: M
authors.lastname: Adamik
authors.forename: Lothar
authors.initials: L
authors.lastname: Willmitzer
authors.forename: Holger
authors.initials: H
authors.lastname: Hesse
authors.forename: Rainer
authors.initials: R
authors.lastname: Hoefgen
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D019295:Computational Biology; D003470:Culture Media; D020224:Expressed Sequence Tags; D018745:Genome, Plant; D063245:Plant Development; D018521:Plant Physiological Phenomena; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D013455:Sulfur / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D003470:Culture Media; D013455:Sulfur