[Study on the injury effect of ammonium perchlorate to lung].
OBJECTIVE
To study the injury effect of ammonium perchlorate (AP) to lung and to explore whether AP can cause pulmonary fibrosis.


METHODS
To detect the levels of cell counts, TNF-alpha, MDA, HYP and the synthesis of collagen in BALF or rat lung after a certain time when rats were injected AP by intratracheal instillation.


RESULTS
AP could bring about acute lung damage and inflammatory reaction. The levels of TNF-alpha of different groups in different time were obviously higher than the normal control group(P < 0.05). AP could affect the levels of MDA, HYP and the synthesis of collagen. But it had no obviously pathological change of pulmonary fibrosis.


CONCLUSIONS
There were acute injury effect about AP to lung, but this experiment could not make sure whether AP could cause pulmonary fibrosis.
Yang
Haibing
H
Public Health School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Peng
Kailiang
K
Chu
Qilong
Q
Zhao
Suli
S
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008315:Malondialdehyde / Q000032:analysis; D010472:Perchlorates / Q000633:toxicity*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D010472:Perchlorates; D000644:Quaternary Ammonium Compounds; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D006909:Hydroxyproline; C053506:ammonium perchlorate