title: Expression of human tumor-associated antigen RCAS1 in adult T-cell leukemia/lymphoma.
abstract: In human cancer, RCAS1 (the receptor-binding cancer antigen expressed on SiSo cells) on the surface of various kinds of tumor cells reportedly induces the apoptosis of T-cells and natural killer cells, resulting in evasion of the immune system. In the present study, an immunohistochemical analysis of RCAS1 expression was performed with lymph node specimens obtained from patients with adult T-cell leukemia/lymphoma (ATLL). Positive staining was seen in 15 (75%) of 20 cases and in all cases of patients with short survival times. In the cases of B-cell lymphomas, positive staining was seen in only 1 (13%) of 8 cases. These findings indicate that expression of RCAS1 may be associated with the evasion from immune surveillance of cells infected with human T-lymphotropic virus type I, resulting in the development of overt leukemia/lymphoma. Determination of RCAS1 expression may be useful for predicting the prognosis of patients with ATLL.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. mmmmm@intmed3.med.kyushu-u.ac.jp
authors.forename: Koichiro
authors.initials: K
authors.lastname: Muta
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Naokuni
authors.initials: N
authors.lastname: Uike
authors.forename: Ilseung
authors.initials: I
authors.lastname: Choi
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Matsushima
authors.forename: Junji
authors.initials: J
authors.lastname: Nishimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Nakashima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Hajime
authors.initials: H
authors.lastname: Nawata
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis*; D015820:Cadherins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D000951:Antigens, Neoplasm; D015820:Cadherins; C120762:EBAG9 protein, human