title: MR imaging of mouse leptomeningeal metastases.
abstract: To develop new treatment strategies for patients with leptomeningeal metastases (LM), potential therapeutic agents have to be tested in murine models first. In vivo magnetic resonance imaging has an additive value in non-invasive monitoring of the effects of therapeutic agents on LM. Previously, we described a reproducible mouse model for B16F-10 melanoma LM. In this paper, we visualize leptomeningeal melanoma metastases in mice on both T2 weighted MR images and gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1 weighted MR images, using a 4.7T MR spectrometer. We conclude that both MR sequences can be used to detect and monitor LM of melanoma cells in mice. Our data further suggest that LM are more clearly visualized using T1 weighted Gd-DTPA enhanced subtraction imaging than T2 weighted imaging.
authors.affiliation: Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands. d.brandsma@neuro.azu.nl
authors.forename: Dieta
authors.initials: D
authors.lastname: Brandsma
authors.forename: Martin J B
authors.initials: MJ
authors.lastname: Taphoorn
authors.forename: Jaap C
authors.initials: JC
authors.lastname: Reijneveld
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Nas
authors.forename: Emile E
authors.initials: EE
authors.lastname: Voest
authors.forename: Klaas
authors.initials: K
authors.lastname: Nicolay
authors.forename: Erwin
authors.initials: E
authors.lastname: Blezer
mesh_terms: D000818:Animals; D003287:Contrast Media; D004195:Disease Models, Animal; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008297:Male; D008546:Melanoma, Experimental / Q000473:pathology* / Q000556:secondary; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000556:secondary*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA