title: Teaching cancer cells to die.
abstract: Tumor cells have evolved numerous mechanisms to thwart apoptosis. As our understanding of the machinery which regulates cell-death evolves, these apoptotic defects have fallen into the crosshairs of cancer drug developers. The issues raised in exploiting these alterations for therapeutic benefit are discussed.
authors.affiliation: Novartis Institute for Biomedical Research, Oncology Biology, East Hanover, New Jersey 07936, USA. leigh.zawel@pharma.novartis.com
authors.forename: Leigh
authors.initials: L
authors.lastname: Zawel
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction