Understanding HIV-1 drug resistance.
Infection with drug-resistant HIV-1 may result from the acquisition of mutant strains or from their selection within the individual; either can compromise the efficacy of antiretroviral therapy (ART). Drug-resistance testing is recommended to assist in the choice of ART. Herein, factors that contribute to the selection of drug-resistant virus and details important to the interpretation of the genotypic and phenotypic susceptibility test results are reviewed.
Frenkel
Lisa M
LM
Department of Pediatrics, University of Washington, Seattle, WA, USA. lfrenkel@u.washington.edu
Tobin
Nicole H
NH
D019380:Anti-HIV Agents / Q000494:pharmacology / Q000627:therapeutic use*; D024882:Drug Resistance, Viral / Q000235:genetics; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D010641:Phenotype; D017410:Practice Guidelines as Topic; D014773:Virology / Q000379:methods
D019380:Anti-HIV Agents