[Dyslipidemia].
Metabolic syndrome has been proposed to indicate individuals in whom the coexistence of three or more factors with obesity or insulin resistance precipitates ischemic cardiac disease, although each individual risk factor is not severe when taken into consideration separately. Reaven used the term 'syndrome X' to indicate cases in whom hyperinsulinemia, IGT, low blood HDL(high-density lipoprotein)-cholesterol level, high blood VLDL(very low density lipoprotein) triglyceride level, and hypertension are all present. Visceral fat syndrome caused by accumulation of visceral fat has also been proposed. These conditions are accompanied by certain concomitant risk factors such as obesity, hypenutrition, insufficient exercise, and genetic predisposition, and are related to insulin resistance. A decrease in triglyceride degradation by lipoprotein lipase due to insulin resistance leads to an increase in remnant particles and a decrease in HDL.
Yamada
Nobuhiro
N
Institute of Clinical Medicine, University of Tsukuba.
D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000378:metabolism*