title: Effects of intravenously administered human atrial natriuretic peptide on elevated blood pressure during surgery.
abstract: The effect of human atrial natriuretic peptide (hANP) on blood pressure (Bp) was evaluated in 11 patients who had elevated systoric Bp of over 150 mmHg during surgery. A bolus injection of 50 microg or 100 microg of hANP decreased Bp with an immediate response by 27.6 +/- 3.1 mmHg (P < 0.001) or 40.7 +/- 4.2 mmHg (P < 0.001), respectively, accompanying with tremendously increased urine output. Heart rate and PaO2 were not altered. Thus, a intravenous bolus injection of hANP is an useful therapeutic tool for the treatment of acutely elevated Bp during anesthesia.
authors.affiliation: Department of Anesthesiology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Iwatsuki
authors.forename: M
authors.initials: M
authors.lastname: Katoh
authors.forename: A
authors.initials: A
authors.lastname: Yasuda
authors.forename: S
authors.initials: S
authors.lastname: Saitoh
authors.forename: M
authors.initials: M
authors.lastname: Asano