Whipple's disease with neurological manifestations: case report.
Whipple's disease (WD) is an uncommon multisystem condition caused by the bacillus Tropheryma whipplei. Central nervous system involvement is a classical feature of the disease observed in 20 to 40% of the patients. We report the case of a 62 year old man with WD that developed neurological manifestations during its course, and discuss the most usual signs and symptoms focusing on recent diagnostic criteria and novel treatment regimens.
França
Marcondes C
MC
Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil. mcfjunior@ig.com.br
Castro
Rafael de
Rd
Balthazar
Márcio Luiz F
ML
Malveira
George Linard S
GL
Pirani
Clodoaldo
C
Deus-Silva
Leonardo
L
Paz
Alexandre R da
AR
Queiroz
Luciano S
LS
Damasceno
Benito P
BP
D001706:Biopsy; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000175:diagnosis / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
D015662:Trimethoprim, Sulfamethoxazole Drug Combination