Percutaneous delivery of carbamazepine and selected N-alkyl and N-hydroxyalkyl analogues.
Advantages associated with the transdermal delivery route are well documented, but in the past scientists have concentrated primarily on means of decreasing the barrier function of the skin for improved permeability. Pro-drugs, which possess more favourable physicochemical properties for improved transdermal permeability may have considerable potential. These have been considered in the past but recent information concerning structure activity relationships in dermal penetration has prompted increased interest. During this study, N-methyl (2), N-ethyl (3) and N-(2-hydroxyethyl) carbamazepine (4) analogues were synthesised for transdermal evaluation.
Fourie
L
L
School of Pharmacy, North-West University, Potchefstroom 2520, South Africa.
Breytenbach
J C
JC
Du Plessis
J
J
Goosen
C
C
Swart
H
H
Hadgraft
J
J
D000279:Administration, Cutaneous; D002220:Carbamazepine / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010539:Permeability; D012869:Skin Absorption; D012995:Solubility; D044366:Transition Temperature
D002220:Carbamazepine