title: Role of humoral factors in the regulation of hemopoiesis during immobilization stress.
abstract: Experiments were performed on CBA/CaLac mice with hyperplasia of hemopoiesis induced by 10-h immobilization. Erythropoietic and colony-stimulating activity increased under the influence of hemopoietic growth factors and other humoral substances, which plays a major role in the increase in bone marrow cellularity during immobilization stress. Erythropoietin stimulated proliferation of erythroid colony-forming units, while granulocyte colony-stimulating factor accelerated maturation of granulocyte precursors.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
authors.forename: E V
authors.initials: EV
authors.lastname: Kirienkova
authors.forename: E D
authors.initials: ED
authors.lastname: Gol'dberg
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis / Q000502:physiology; D004921:Erythropoietin / Q000037:antagonists & inhibitors / Q000502:physiology; D016179:Granulocyte Colony-Stimulating Factor / Q000037:antagonists & inhibitors / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D007103:Immobilization / Q000009:adverse effects / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D038042:Myelopoiesis / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D000911:Antibodies, Monoclonal; D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor