title: Potent antioxidative activity of cacalol, a sesquiterpene contained in Cacalia delphiniifolia Sleb et Zucc.
abstract: The potent antioxidative sesquiterpene, cacalol, was isolated from Cacalia delphiniifolia Sleb et Zucc, and identified by an analysis of the MS and NMR spectral data. Cacalol showed potent antioxidative activity in a rat brain homogenate model (IC(50) of 40 nM). Cacalol also proved to be a potent neuroprotective substance which could protect neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity.
authors.affiliation: Department of Food and Nutrition, Japan Women's University, Tokyo, Japan. kshindo@fc.jwu.ac.jp
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shindo
authors.forename: Mari
authors.initials: M
authors.lastname: Kimura
authors.forename: Mayuko
authors.initials: M
authors.lastname: Iga
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002460:Cell Line; D018698:Glutamic Acid / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D018696:Neuroprotective Agents / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D012717:Sesquiterpenes; C497192:cacalol; D018698:Glutamic Acid