Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.
Of the several kinds of therapy-related leukemia, therapy-related acute promyelocytic leukemia (t-APL) is most closely associated with topoisomerase II inhibitor administration for treatment of malignancies in adults. Although rare in children, the majority of therapy-related malignancies have been etoposide-related APL associated with Langerhans cell histiocytosis. The authors describe the development of t-APL after chemotherapy administered for non-Hodgkin's lymphoma (NHL) in an 8-year-old girl. One month after cessation of the 3-year chemotherapy regimen of doxorubicin and other agents but not etoposide or radiotherapy, the patient was diagnosed with t-APL with positive PML-RARA molecular abnormality. The patient attained a complete remission following treatment with all-trans retinoic acid-containing chemotherapy. Thereafter, she successfully received hematopoietic stem cell transplantation from an HLA-matched sibling donor. Development of t-APL associated with NHL in children appears to be rare.
Ogami
Aya
A
Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan. ayaoga@koto.kpu-m.ac.jp
Morimoto
Akira
A
Hibi
Shigeyoshi
S
Todo
Shinjiro
S
Sugimoto
Tohru
T
Mori
Kanako
K
Imamura
Toshihiko
T
Ishida
Hiroyuki
H
Yoshihara
Takao
T
Iguchi
Akihiro
A
Imaizumi
Masue
M
Imashuku
Shinsaku
S
D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D016133:Polymerase Chain Reaction; D012074:Remission Induction; D014178:Translocation, Genetic
D000970:Antineoplastic Agents