title: Synthesis and biological evaluation of flavonoids as vasorelaxant agents.
abstract: Several 5,7-dihydroxyflavone and quercetin 3-O-glycosides have been synthesized and evaluated for vasorelaxant activity. A log P-activity relationship amongst flavonoids was suggested.
authors.affiliation: Department of Medicinal Chemistry, Zhejiang University, School of Pharmaceutical Science, Hangzhou 310031, PR China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Chen
authors.forename: Yongzhou
authors.initials: Y
authors.lastname: Hu
authors.forename: Haohao
authors.initials: H
authors.lastname: Wu
authors.forename: Huidi
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000502:physiology; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D066298:In Vitro Techniques; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D005419:Flavonoids; D014665:Vasodilator Agents