title: Successful treatment of subfoveal choroidal neovascularization associated with combined hamartoma of the retina and retinal pigment epithelium.
abstract: OBJECTIVE
  To describe a patient with subfoveal choroidal neovascularization (CNV) associated with combined hamartoma of the retina and retinal pigment epithelium (CHRRPE), treated successfully by submacular surgery.
  
  
  METHODS
  Interventional case report.
  
  
  METHODS
  A 12-year-old girl was referred to our clinic for evaluation. Visual acuity was 20/30 in the affected left eye. Ophthalmoscopy disclosed juxtapapillary CHRRPE and subfoveal pigmented CNV. Vitreous surgery was carried out because of visual deterioration to 20/60.
  
  
  RESULTS
  The posterior vitreous was strongly attached to glial tissue at the superior margin of the optic disk in the CHRRPE region. The CNV, which was not connected with the CHRRPE, was carefully removed, resulting in visual improvement to 20/20 5 months after surgery. Histologically, the excised membrane showed fibroblast-rich cellular component and a type 2 configuration.
  
  
  CONCLUSIONS
  Submacular surgery can be effective for the treatment of secondary CNV associated with CHRRPE.
authors.affiliation: Ophthalmology Department, Keio University School of Medicine, 35 Shianomachi, Shinjyuku, Tokyo 160-8582, Japan. inoshin@sc.itc.keio.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Inoue
authors.forename: Koushuke
authors.initials: K
authors.lastname: Noda
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
authors.forename: Takefumi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Nagai
authors.forename: Kei
authors.initials: K
authors.lastname: Shinoda
authors.forename: Hajime
authors.initials: H
authors.lastname: Shinoda
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Oguchi
mesh_terms: D002648:Child; D020256:Choroidal Neovascularization / Q000209:etiology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis; D006222:Hamartoma / Q000150:complications / Q000601:surgery*; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000601:surgery*; D012164:Retinal Diseases / Q000150:complications / Q000601:surgery*; D014792:Visual Acuity; D014821:Vitrectomy