Two new metabolites from the mangrove endophytic fungus no. 2524.
Two new metabolites, the cyclo-(L-Phe-L-Leu1-L-Leu2-L-Leu3-L-Ile) (1) and (3S,4R)-dihydroxy-(6S)-undecyl-alpha-pyranone (2) have been produced by the endophytic fungus no. 2524 isolated from a seed of mangrove Avicennia marina in Hong Kong. The structures have been elucidated by spectra including two-dimensional NMR, ESI tandem mass spectrometry and CD. These compounds show no activity toward human cancer cell lines Bel-7402, NCI-4460 and the normal human cell lines L-02.
Li
Hou-Jin
HJ
School of Chemistry and Chemical Engineering, Zhongshan University, Guangzhou 510275, China.
Lin
Yong-Cheng
YC
Yao
Jun-Hua
JH
Vrijmoed
L L
LL
Jones
Gareth E
GE
D032407:Avicennia / Q000382:microbiology*; D045744:Cell Line, Tumor / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds
D010936:Plant Extracts