title: Regression of gastric malt-lymphoma under specific therapy may be predict by endoscopic ultrasound.
abstract: Mucosa-associated lymphoid tissue (MALT) lymphomas represent a relatively new described class of rare lymphomas, characterized by an indolent course and favourable outcome with specific therapy. Gastric MALT lymphomas are associated with chronic Helicobacter pylori (HP) infection. We report the case of a 67 year old man admitted for an 8-month history of epigastric pain, anorexia and progressive weight loss. He was diagnosed with low-grade primary gastric MALT lymphoma by endoscopy, histopathological examination of gastric mucosa (light microscopy and immunohistochemistry) and endoscopic ultrasonography (EUS). The patient received a 2-week course of anti-HP therapy and chemotherapy with Chlorambucil 0.1 mg/kg/day was started. During the follow-up, continuous improvement of clinical status, endoscopic and EUS appearance was noted. We conclude that, facing the trend toward nonsurgical treatment modalities for primary gastric lymphoma, EUS appears an important tool for staging the disease and defining cases suitable for anti-HP, radio- and chemotherapy, as well as for the detection of local recurrence.
authors.affiliation: Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Sos. Fundeni no. 258, 72437 Bucharest, Romania. drgheorghe@xnet.ro
authors.forename: Cristian
authors.initials: C
authors.lastname: Gheorghe
authors.forename: Ion
authors.initials: I
authors.lastname: Băncilă
authors.forename: Răzvan
authors.initials: R
authors.lastname: Stoia
authors.forename: Liana
authors.initials: L
authors.lastname: Gheorghe
authors.forename: Gabriel
authors.initials: G
authors.lastname: Becheanu
authors.forename: Camelia
authors.initials: C
authors.lastname: Dobre
authors.forename: Raluca
authors.initials: R
authors.lastname: Brescan
mesh_terms: D000368:Aged; D019160:Endosonography; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology