Hepatoprotective flavonol glycosides from the aerial parts of Rodgersia podophylla.
A new acylated flavonoid, quercetin 3- O-alpha- L-(5"- O-acetyl)-arabinofuranoside ( 1), along with six known flavonoids ( 2 - 7) were isolated from the aerial parts of Rodgersia podophylla. The new flavonoid 1 exhibited 50.1 % hepatoprotective activity at a concentration of 100 microM, and the three known compounds 3, 5 and 6 showed hepatoprotective activities at a concentration of 50 microM (45.7, 50.8 and 57.3 %, respectively) by using the primary cultures of rat hepatocytes injured by H (2)O (2).
Chin
Young-Won
YW
College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, San 56-1, Shinlim-dong, Kwanak-gu, Seoul 151-742, Korea.
Lim
Song Won
SW
Kim
Young Choong
YC
Choi
Sang Zin
SZ
Lee
Kang Ro
KR
Kim
Jinwoong
J
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D005419:Flavonoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006027:Glycosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D022781:Hepatocytes / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D031995:Saxifragaceae
D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; D020011:Protective Agents