Targeting interferon-alpha: a promising approach for systemic lupus erythematosus therapy.
System lupus erythematosus (SLE) is an autoimmune disease with multicellular pathogeneic components. Recent studies suggest an important role for interferon-alpha (IFN) in the immunopathogenesis of SLE. Data demonstrating a correlation between IFN-alpha and SLE disease severity range from elevated IFN-alpha levels in patients' serum and induction of IFN-regulated genes in peripheral blood mononuclear cells, to drug induced lupus disease in hepatitis C or cancer patients treated with recombinant IFN-alpha. In addition, mouse models of lupus in which the IFNR is deleted fail to develop disease manifestations. Thus, targeting IFN-alpha promises to be therapeutically efficacious for SLE.
Schmidt
K N
KN
Department of Immunology, Genentech Inc., San Francisco 94080, USA. kerstin@gene.com
Ouyang
W
W
D000818:Animals; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D051379:Mice
D016207:Cytokines; D016898:Interferon-alpha