title: Elevated serum surfactant protein A and D in a case of acute eosinophilic pneumonia.
abstract: A 29-year-old man was admitted to our hospital because of fever elevation, dry cough, malaise, skin eruption, and dyspnea with hypoxemia. His serum levels of surfactant protein (SP) -A and SP-D were markedly high, but serum KL-6 was not. He was diagnosed as acute eosinophilic pneumonia (AEP) on the basis of CT imaging, bronchoalveolar lavage findings and the clinical course. He showed good response to steroid therapy and serum levels of SP-A and SP-D returned to almost normal levels. Our experience suggested that serum SP-A and SP-D might be helpful markers for monitoring the clinical course in AEP.
authors.affiliation: Third Department of Internal Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo 060-8543.
authors.forename: Masaru
authors.initials: M
authors.lastname: Fujii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Masami
authors.initials: M
authors.lastname: Kameda
authors.forename: Masanori
authors.initials: M
authors.lastname: Fujii
authors.forename: Shintaro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ohashi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Chiba
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shosaku
authors.initials: S
authors.lastname: Abe
mesh_terms: D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy*; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood*; D011663:Pulmonary Surfactants / Q000097:blood; D013902:Radiography, Thoracic; D018570:Risk Assessment; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants; D013256:Steroids