Comparative effect of different types of food on the bioavailability of cefaclor extended release tablet.
This randomized, six-treatment, six-period, six sequence, single dose, crossover pharmacokinetic study assessed the effect of different types of food on the bioavailability of 500-mg cefaclor extended release tablet in 23 healthy male volunteers. A single dose of cefaclor extended release 500-mg tablet was administered at six occasions: after overnight fasting, after two vegetarian (high-fat and low-fat), two non-vegetarian (high-fat and low-fat) and rice diets. Serial blood samples were collected up to 12 h after dose. Serum cefaclor concentrations were determined by a validated HPLC method. An almost equivalent increase in both Cmax and AUC was observed with both high-fat non-vegetarian and low-fat vegetarian breakfasts. However, when MIC90 values, a pharmacodynamic end-point were compared, the low-fat vegetarian diet fared better than the high-fat non-vegetarian diet. The results obtained favor low-fat vegetarian diet (breakfast) to be taken with cefaclor extended release tablet to achieve maximum benefit in terms of clinical efficacy.
Khan
B A H
BA
Department of Pharmaceutical Medicine, Faculty of Pharmacy, Majeedia Hospital, Jamia Hamdard, Hamdard University, Hamdard Nagar, New Delhi, India.
Ahmed
T
T
Karim
S
S
Monif
T
T
Saha
N
N
Sharma
P L
PL
D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D002433:Cefaclor / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002511:Cephalosporins / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D018752:Diet, Fat-Restricted; D014676:Diet, Vegetarian; D004041:Dietary Fats / Q000494:pharmacology; D018565:Food-Drug Interactions; D006801:Humans; D016014:Linear Models; D008297:Male; D012275:Oryza; D014908:Triticum
D002511:Cephalosporins; D003692:Delayed-Action Preparations; D004041:Dietary Fats; D002433:Cefaclor