title: Weight change and cognitive performance.
abstract: OBJECTIVE
  To investigate whether under- or overweight and weight change is associated with cognitive performance of elderly citizens.
  
  
  METHODS
  Explorative analysis out of the Basel Study cohort.
  
  
  METHODS
  In all, 531 healthy subjects (445 men/86 women) were assessed with the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB) in 2000 (age: 69.4+/-7.8 y) and weight measurements obtained in 1990 (body mass index (BMI): 25.2+/-3.1 kg/m(2)) and in 2000 (BMI: 25.6+/-3.4 kg/m(2)).
  
  
  METHODS
  The predictive power of the annual change in BMI with cognitive performance was investigated by a binary logistic regression analysis (backward) using sex, age, BMI 1990, BMI 2000, diastolic blood pressure, diabetes status, and optimal health status as additional predictors.
  
  
  RESULTS
  In the last step, the following variables remained in the model: annual change in BMI (quadratic term; P<0.01); ApoE genotype (P<0.05); and optimal health status (P<0.01).
  
  
  CONCLUSIONS
  The association between the extent of weight change and poorer cognitive performance could be either a consequence of cognitive impairment or an early symptom of neurodegenerative decline.
authors.affiliation: Memory Clinic, Geriatric University Hospital, Basel, Switzerland. dorothee.brubacher@unibas.ch
authors.forename: D
authors.initials: D
authors.lastname: Brubacher
authors.forename: A U
authors.initials: AU
authors.lastname: Monsch
authors.forename: H B
authors.initials: HB
authors.lastname: Stähelin
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D001057:Apolipoproteins E