Application of solubilizing properties of the products of oxyethylenated fatty alcohols of the Brij type in relation to simvastatin.
Investigation of 3-hydroxy-3-methyl-glutaril-coenzyme A inhibitors (statins) has influenced considerably the process of treatment of dislipidemy; now they belong to the most frequently prescribed hypolipemizing medicines. As it has been proved through randomized clinical examination, it is believed to be related to their complex pharmacological action that statins cause certain clinical effects such as a decrease in the morbidity and mortality rate resulted from vessel diseases referred to artheriosclerotic changes. It has been also proved the statine's beneficial influence during the primary and secondary preventive treatment for ischaemic heart disease, ischaemic stroke in the case of patients with diagnosed changes in the vascular system. Moreover, it has been proved the clinical usability in the preventive treatment for osteoporotic changes in bones [4]. The aim of the preformulary examination is to determine solubilizing properties of oxyethylenated fatty alcohols of the Brij type in the relation to simvastatin. Estimation of pharmaceutical accessibility of simvastatin in model form of drug made it possible to establish the influence of supportive substances on the process of equilibrial solubilization of biologically active substance in the recipe liquid--0.1n HCl.
Ginter
Paweł Marek
PM
Institute Technology and Chemistry Pharmaceutical, Department of Dispensing Pharmacy, Medical University of Lodz.
Zgoda
Marian Mikołaj
MM
D000924:Anticholesteremic Agents / Q000378:metabolism*; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism*; D019821:Simvastatin / Q000378:metabolism*; D012995:Solubility
D000924:Anticholesteremic Agents; D005233:Fatty Alcohols; D019821:Simvastatin