Myocardial infarction during factor IX infusion in hemophilia B: case report and review of the literature.
There are very few reports in the literature of acute myocardial infarction (MI) occurring during infusion of factor concentrates, particularly cryosupernatant in patients with hemophilia B. We describe a case of a 61-year-old man with hemophilia B who suffered an acute MI while receiving cryosupernatant infusion as factor replacement therapy. Cryosupernatant is rich in coagulation factor IX and contains low levels of fibrinogen and von Willebrand's factor. Factor IX and other factors present in cryosupernatant can possibly become activated during the manufacturing process causing thrombus formation in patients who are prone to it.
Najaf
Syed Muhammad
SM
Section of Cardiology, Department of Medicine, Aga Khan University, Stadium Road, Karachi, Pakistan. najaf.nadeem@aku.edu
Malik
Amyn
A
Quraishi
Ata-Ur-Rehman
AU
Kazmi
Khawar
K
Kakepoto
Ghulam Nabi
GN
D000368:Aged; D005164:Factor IX / Q000627:therapeutic use*; D002836:Hemophilia B / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*
D005164:Factor IX