[Effects of chronic alcohol administration on the activities of the key glycolytic enzymes of rats].
In order to study the effects of chronic alcohol administration on the activities of the key glycolytic enzymes, a oral administration of alcohol solution in different concentrations was given to rats for 9 weeks. The activities of glucokinase (GK), phosphofructokinase (PFK) and hexokinase (HK) in liver were determined at the end of the study. The results showed that the activities of GK and PFK in the groups administrated with 30% and 50% alcohol solution decreased obviously in comparison with that in control group (P < 0.05). But the activity of HK had no significant differences in all five groups. Correlation analysis indicated that the activities of GK and PFK were correlated with the dose of alcohol significantly (r = -0.99(-)-0.97, P < 0.05). These results demonstrated that chronic alcohol administration can suppress the glycolytic pathway. They can also be one of the mechanisms of diabetes mellitus relating to alcohol because of the high blood sugar and the disturbed blood sugar regulation.
Pang
Hong
H
Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Zhang
Jun
J
Mao
Limei
L
Yang
Nianhong
N
D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D005260:Female; D005941:Glucokinase / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D025221:Phosphofructokinases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D025221:Phosphofructokinases; D006593:Hexokinase; D005941:Glucokinase