title: A topical metronidazole gel used to treat malodorous wounds.
abstract: Patients with malodorous wounds often experience social isolation, depression, shame, embarrassment and poor appetite, all of which can have a negative impact on their quality of life. The healthcare professionals caring for them face difficult clinical challenges in terms of treating the cause and managing the symptoms. This study employed a randomized, placebo-controlled double blind design to investigate the effectiveness of metronidazole gel on wound malodour, the main focus of this article. In addition, changes in self-report of mood state were also explored. There was a 100% success rate for the metronidazole gel, mostly within 3 days, with no adverse events reported. As there was a 76% success rate in the placebo group, there was no significant difference in success rates between the two groups. Odour ratings given by patients and nurses were significantly correlated (P<0.001). There was no significant difference in mood state between the groups over time. This study provides some evidence to support the use of metronidazole gel in the treatment of patients with malodorous wounds, but indicates the need for further research in this area.
authors.affiliation: Nursing Research, University of Wales College of Medicine, Cardiff, Wales, UK.
authors.forename: Sue
authors.initials: S
authors.lastname: Bale
authors.forename: Nicky
authors.initials: N
authors.lastname: Tebbie
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D000279:Administration, Cutaneous; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001291:Attitude of Health Personnel; D001294:Attitude to Health; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D009336:Necrosis; D009730:Nursing Assessment; D009741:Nursing Staff, Hospital / Q000523:psychology; D009812:Odorants / Q000517:prevention & control*; D010146:Pain / Q000175:diagnosis / Q000209:etiology; D011788:Quality of Life; D012720:Severity of Illness Index; D017592:Skin Care / Q000379:methods / Q000451:nursing; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing; D014946:Wound Infection / Q000188:drug therapy* / Q000451:nursing / Q000473:pathology / Q000523:psychology
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D008795:Metronidazole