title: Recurrence rate of pre-eclampsia in women with thrombophilia influenced by low-molecular-weight heparin treatment?
abstract: OBJECTIVE
  (1) To assess the recurrence rate of pre-eclampsia in women with this history before 34 weeks of pregnancy and thrombophilia. (2) To evaluate the effects of low-molecular-weight heparin (LMWH) on pregnancy outcome.
  
  
  METHODS
  In a multicentre retrospective study subsequent pregnancies of women with a history of pre-eclampsia necessitating birth before 34 weeks and thrombophilia were analysed. Of 58 women, 26 received LMWH and aspirin (ASA) and 32 ASA (22) or no (10) medication in their subsequent pregnancies.
  
  
  RESULTS
  In eight women treated with LMWH and ASA and in 16 women receiving ASA or no medication pre-eclampsia recurred in the subsequent pregnancy. (OR 0.55, 95% CI 0.15-1.31) There were no significant differences in birth weight or gestational age between both groups.
  
  
  CONCLUSIONS
  The recurrence rate of pre-eclampsia in women with thrombophilic disorders is high in this small retrospective study. No positive effect was found for LMWH treatment. A multicentred randomised study has been started to reach an adequate number of patients to evaluate the influence of LMWH treatment.
authors.affiliation: Department of Obstetrics and Gynaecology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam. JJ.Kalk@VUmc.nl
authors.forename: J J
authors.initials: JJ
authors.lastname: Kalk
authors.forename: A J M
authors.initials: AJ
authors.lastname: Huisjes
authors.forename: C J M
authors.initials: CJ
authors.lastname: de Groot
authors.forename: E
authors.initials: E
authors.lastname: van Beek
authors.forename: M G
authors.initials: MG
authors.lastname: van Pampus
authors.forename: M E A
authors.initials: ME
authors.lastname: Spaanderman
authors.forename: J
authors.initials: J
authors.lastname: van Eyck
authors.forename: S G
authors.initials: SG
authors.lastname: Oei
authors.forename: P D
authors.initials: PD
authors.lastname: Bezemer
authors.forename: J I P
authors.initials: JI
authors.lastname: de Vries
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D018890:Chemoprevention; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D018579:Patient Selection; D011225:Pre-Eclampsia / Q000150:complications / Q000473:pathology / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012008:Recurrence; D012189:Retrospective Studies; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight