Changes in cochlear blood flow due to endotoxin-induced otitis media.
The purpose of this study was to elucidate the influence of otitis media on blood flow in the lateral wall of the cochlea by means of a model of endotoxin-induced otitis media. The cochlear blood flow (CBF) following lipopolysaccharide inoculation into the middle ear cavities of rats was measured by laser-Doppler flowmetry and compared with that of untreated ears. After this evaluation, the influence on CBF of concomitant use of a nitric oxide synthase inhibitor was also investigated. The first day after inoculation, the CBF of treated ears decreased significantly. This decrease recovered gradually between the 7th and 14th days. With concomitant use of a nitric oxide synthase inhibitor, the decrease in CBF was prevented to some extent. The results showed a functional influence upon CBF by endotoxin-induced otitis media. The significance of prophylactic use of the drug is also discussed in regard to the effect on CBF following otitis media.
Sone
Michihiko
M
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Hayashi
Hideo
H
Tominaga
Mitsuo
M
Nakashima
Tsutomu
T
D000578:Amidines / Q000494:pharmacology; D000818:Animals; D003051:Cochlea / Q000098:blood supply* / Q000473:pathology; D005260:Female; D006574:Heterocyclic Compounds, 2-Ring / Q000494:pharmacology; D017078:Laser-Doppler Flowmetry; D008070:Lipopolysaccharides; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010033:Otitis Media / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects
C407360:7-chloro-3-imino-5-methyl-2-azabicyclo(4.1.0)heptane; D000578:Amidines; D006574:Heterocyclic Compounds, 2-Ring; D008070:Lipopolysaccharides; D019001:Nitric Oxide Synthase