[Prognostic values of oestradiol/oocyte rate in ICSI patients].
OBJECTIVE
To analyze the pregnancy rate in women who underwent Intracytoplasmic Sperm Injection (ICSI) program depending of the oestradiol/oocyte index.


METHODS
Retrospective, comparative.


METHODS
332 patients were included. There were divided in three groups depending on the oestradiol/oocyte index: Group A:(100 pg/mL, group B: 101-250 pg/mL and group C: > 250 pg/mL). Therapeutic protocol. Down regulation with leuprolide acetate in late luteal phase protocol, COH with rec-FSH and / or HMG, ultrasonographic and estradiol blood levels were monitored; hCG application when > 3 follicles > 18 mm, oocyte retrieval performed 34 hours later. We analyzed: patient age, male age, number of follicles, estradiol serum levels at the day of hCG application, number of mature oocytes, oestradiol/oocyte index, fertilization rate, transferred embryos, transfer quality, catheter type and luteal support. Statistical analysis (SPSS 11) with chi square, ANOVA and Kruskall-Wallis was used.


RESULTS
On having analyzed the number of metaphase II oocytes retrieval, oocytes fertilized and number of transferred embryos among three groups, the best results were obtained in group B. The differences among these variables were significant. (P = 0.014, p = 0.005 and p = 0.003, respectively). When the oestradiol/oocyte index was analyzed and the PR among groups (21.83, 36.62 and 17.80 %) we observed a significant difference (p = 0.003).


CONCLUSIONS
It is convenient to monitor the oestradiol blood levels to offer schemes of COH less aggressive to improve the oocyte quality. The oestradiol/oocyte index is a parameter adapted as a predictive value of pregnancy.
Galache Vega
Pedro
P
Instituto para el Estudio de la Concepción Humana, Monterrey, NL.
Saucedo de la Llata
Eric
E
Treviño Rodríguez
Armando
A
Santos Haliscak
Roberto
R
Batiza Reséndiz
Víctor Alfonso
VA
Arenas Montezco
Lidia
L
Moraga Sánchez
María Rosa
MR
Sepúlveda González
José
J
Leal Almeida
Manuel
M
Rodríguez Pezino
Jorge
J
García Villafaña
Genaro
G
Hernández Ayup
Samuel
S
D000328:Adult; D002452:Cell Count; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D010063:Ovum; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic
D004958:Estradiol