title: Adult Still's disease reflects a Th2 rather than a Th1 cytokine profile.
abstract: Adult Still's disease (ASD) is a chronic multisystemic disease. Extraordinarily high serum levels of IL-18 in ASD patients have been described, whereas the mechanism remains to be clarified. This study aimed to evaluate proinflammatory cytokines and to consider their pathological roles. In patients with rheumatic diseases (n = 151), blood samples were taken at the active phase and the serum levels of IL-18 and other proinflammatory cytokines were measured by ELISA. The extra-high levels of IL-18 were confirmed selectively in ASD patients (n = 10). In the active phase of ASD patients, the levels of IL-6 were elevated accordingly, but IL-1beta and TNF-alpha were undetectable. As to Th1-Th2 cytokines, the levels of IL-4 and IL-13, but not INF-gamma, IL-12, or IL-2, were elevated in all ASD patients examined. Moreover, the serum levels of IL-18 showed a good correlation with those of IL-4, suggesting that ASD reflects a Th2 rather than a Th1 cytokine profile.
authors.affiliation: Department of Rehabilitation, Osaka Prefecture College of Nursing, Habikino, Osaka 583-8555, Japan. osaiki@osaka-hsu.ac.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Saiki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uda
authors.forename: Norihiko
authors.initials: N
authors.lastname: Nishimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Miwa
authors.forename: Toru
authors.initials: T
authors.lastname: Mima
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Ogawara
authors.forename: Naoto
authors.initials: N
authors.lastname: Azuma
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Katada
authors.forename: Junko
authors.initials: J
authors.lastname: Sawaki
authors.forename: Hiroko
authors.initials: H
authors.lastname: Tsutsui
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Matsui
authors.forename: Akira
authors.initials: A
authors.lastname: Maeda
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakanishi
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018793:Interleukin-13 / Q000097:blood / Q000276:immunology; D020382:Interleukin-18 / Q000097:blood* / Q000276:immunology; D015847:Interleukin-4 / Q000097:blood / Q000276:immunology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D016706:Still's Disease, Adult-Onset / Q000097:blood / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D018793:Interleukin-13; D020382:Interleukin-18; D015847:Interleukin-4; D002097:C-Reactive Protein