Long-term memory requires polyADP-ribosylation.
PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia. Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosylation enables the transcription needed to form long-term memory without strand breaks in DNA.
Cohen-Armon
Malka
M
Neufeld Cardiac Research Institute, Sheba Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel. marmon@post.tau.ac.il
Visochek
Leonid
L
Katzoff
Ayelet
A
Levitan
David
D
Susswein
Abraham J
AJ
Klein
Rodika
R
Valbrun
Mireille
M
Schwartz
James H
JH
D000818:Animals; D001048:Aplysia / Q000502:physiology*; D001549:Benzamides / Q000494:pharmacology; D003216:Conditioning, Operant; D004249:DNA Damage; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005247:Feeding Behavior; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000378:metabolism*; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D007526:Isoelectric Point; D007858:Learning; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D009473:Neuronal Plasticity; D009687:Nuclear Proteins / Q000378:metabolism; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology
D001549:Benzamides; D004791:Enzyme Inhibitors; D006657:Histones; D009687:Nuclear Proteins; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D012333:RNA, Messenger; D011064:Poly Adenosine Diphosphate Ribose; D012701:Serotonin; C025160:3-aminobenzamide; D011065:Poly(ADP-ribose) Polymerases