title: MacroPore resorbable devices in craniofacial surgery.
abstract: Resorbable polymer implants have become a compelling option in the treatment of acquired and congenital craniofacial deformities. The resorbable polylactide (PLa) and polyglycolide (PGa) polymers in particular have demonstrated excellent safety profile sin multiple in vitro, animal, and clinical studies and are currently being used in a wide variety of craniofacial applications. In this article, the authors discuss the biomaterial properties of PLa and PGa resorbable implants and provide an overview of the use of these polymers in craniofacial surgery. They conclude by relating their experience with an ongoing clinical series using MacroPore PLDLa and FRP implants for various applications,including Le Fort osteotomies, midface/monobloc internal distraction, and craniosynostosis reconstruction.
authors.affiliation: Craniofacial Surgery Service, Children's Hospital of San Diego, 8010 Frost Street, #412, San Diego, CA 92123, USA. rholmes@sdfaces.com
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Holmes
authors.forename: Steven R
authors.initials: SR
authors.lastname: Cohen
authors.forename: G Bryan
authors.initials: GB
authors.lastname: Cornwall
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Thomas
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Kleinhenz
authors.forename: Miles Z
authors.initials: MZ
authors.lastname: Beckett
mesh_terms: D020341:Absorbable Implants / Q000009:adverse effects; D000293:Adolescent; D000328:Adult; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D001673:Biodegradation, Environmental; D001696:Biomechanical Phenomena; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D019344:Lactic Acid / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011091:Polyesters / Q000009:adverse effects; D011100:Polyglycolic Acid / Q000009:adverse effects; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000009:adverse effects; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures / Q000379:methods; D012886:Skull / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)