title: Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition.
abstract: Event-related oscillations (ERO) offer an alternative theoretical and methodological approach to the analysis of event-related EEG responses. The P300 event-related potential (ERP) is elicited through the superposition of the delta (1-3 Hz) and theta (3-7 Hz) band oscillatory responses. The cholinergic neurotransmitter system has a key function in modulating excitatory post-synaptic potentials caused by glutamate, and therefore influences P300 generation and the underlying oscillatory responses. Here we report significant linkage and linkage disequilibrium between target case frontal theta band, visual evoked brain oscillations and a single nucleotide polymorphism (SNP) from the cholinergic muscarinic receptor gene (CHRM2) on chromosome 7. We also demonstrate significant linkage disequilibrium between CHRM2 SNPs and target case parietal delta band visual evoked oscillations (LD P<0.001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans.
authors.affiliation: Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA.
authors.forename: Kevin A
authors.initials: KA
authors.lastname: Jones
authors.forename: Bernice
authors.initials: B
authors.lastname: Porjesz
authors.forename: Laura
authors.initials: L
authors.lastname: Almasy
authors.forename: Laura
authors.initials: L
authors.lastname: Bierut
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
authors.forename: Jen C
authors.initials: JC
authors.lastname: Wang
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Dick
authors.forename: Anthony
authors.initials: A
authors.lastname: Hinrichs
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kwon
authors.forename: John P
authors.initials: JP
authors.lastname: Rice
authors.forename: John
authors.initials: J
authors.lastname: Rohrbaugh
authors.forename: Heather
authors.initials: H
authors.lastname: Stock
authors.forename: William
authors.initials: W
authors.lastname: Wu
authors.forename: Lance O
authors.initials: LO
authors.lastname: Bauer
authors.forename: David B
authors.initials: DB
authors.lastname: Chorlian
authors.forename: Raymond R
authors.initials: RR
authors.lastname: Crowe
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Edenberg
authors.forename: Tatiana
authors.initials: T
authors.lastname: Foroud
authors.forename: Victor
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: Samuel
authors.initials: S
authors.lastname: Kuperman
authors.forename: John
authors.initials: J
authors.lastname: Nurnberger
authors.forename: Sean J
authors.initials: SJ
authors.lastname: O'Connor
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: Arthur T
authors.initials: AT
authors.lastname: Stimus
authors.forename: Jay A
authors.initials: JA
authors.lastname: Tischfield
authors.forename: Theodore
authors.initials: T
authors.lastname: Reich
authors.forename: Henri
authors.initials: H
authors.lastname: Begleiter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D003071:Cognition; D003700:Delta Rhythm; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D005625:Frontal Lobe / Q000503:physiopathology; D008040:Genetic Linkage; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D009991:Oscillometry; D010296:Parietal Lobe / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D043585:Receptor, Muscarinic M2 / Q000235:genetics*; D013826:Theta Rhythm
chemical_list: C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2