The prevention of type 2 diabetes mellitus: recent advances.
Diabetes is a major public health problem that is approaching epidemic proportions globally. There is an urgent need for strategies to curb the rising prevalence of this disease, and prevention appears a logical approach. Lifestyle modifications with weight loss and moderate exercise can reduce the incidence of diabetes by >50% in patients with impaired glucose tolerance (IGT). The use of metformin, acarbose and other agents have been shown in randomized prospective trials to prevent type 2 diabetes in high-risk subjects with IGT. Other pharmacological interventions are currently being examined in large prospective studies. It is likely that one or a combination of these approaches could make diabetes prevention a reality in the near future.
Younis
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N
Department of Diabetes and Endocrinology, University Hospital Aintree, Liverpool, UK. naveedy@tinyonlne.co.uk
Soran
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Farook
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S
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D015444:Exercise; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015431:Weight Loss
D007004:Hypoglycemic Agents