Synthesis and optical resolution of 9,9'-spirobifluorene-1,1'-diol.
[reaction: see text] 9,9'-Spirobifluorene-1,1'-diol (SBIFOL) was conveniently synthesized from 1,2-dibromobenzene and 3-bromoanisole in high yield. Both enantiomers of SBIFOL were obtained in 99% ee by inclusion resolution with 2,3-dimethoxy-N,N,N',N'-tetracyclohexylsuccinamide. The absolute configurations were determined by X-ray analysis of a single crystal of molecular complex.
Cheng
Xu
X
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Hou
Guo-Hua
GH
Xie
Jian-Hua
JH
Zhou
Qi-Lin
QL