title: Overexpression of c-erbB-2 oncoprotein and associated pathobiological factors in invasive primary breast cancer.
abstract: Breast cancer tissues from 271 cases were analyzed immunologically for c-erbB-2 oncoprotein (HER-2/neu), epidermal growth factor receptor (EGF-R) and estrogen receptor (ER). Overexpression of both c-erbB-2 oncoprotein and EGF-R showed an inverse association with ER and a direct association with metastatic involvement of lymph node and high histological grade. The frequency of c-erbB-2 and EGF-R overexpression was significantly higher among postmenopausal cases in comparison with premenopausal cases. Further, only in postmenopausal patients, c-erbB-2 oncoprotein (chi2 = 6.4, P < 0.05) and EGF-R (chi2 = 6.4, p < 0.05) as well as their concomitant expression (chi2 = 11.5, p < 0.01) revealed a statistically significant association with ER.
authors.affiliation: Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi 110 002, India.
authors.forename: Amitabha
authors.initials: A
authors.lastname: Ray
authors.forename: Bhuvnesh Kumar
authors.initials: BK
authors.lastname: Sharma
authors.forename: Sudershan
authors.initials: S
authors.lastname: Kaur
authors.forename: Shashi
authors.initials: S
authors.lastname: Sharma
authors.forename: Joginder Kumar
authors.initials: JK
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism*; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis* / Q000502:physiology; D011960:Receptors, Estrogen / Q000096:biosynthesis*
chemical_list: D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen