Arsenic induced free radical toxicity in brain of mice.
The present study was designed to investigate the in vivo effects of oral administration of arsenic trioxide (As2O3; 0.5 and 1 mg/kg body weight/day for 45 days) on cerebral hemispheres and cerebellum in male mice, Mus musculus. Arsenic reduced the concentration of glutathione (GSH) in cerebral hemisphere and cerebellum at both the dose levels; while increased lipid peroxidation (LPO) in cerebral hemisphere and cerebellum regions. Further, the activities of antioxidant enzymes viz., superoxide dismutase and catalase also declined in these two regions with dose indicating oxidative stress. This effect is caused by the action of reactive oxygen species (ROS) induced by arsenic exposure.
Rao
M V
MV
Department of Zoology, University School of Sciences, Gujarat University, Navrangpura, Ahmedabad 380 009, India. zooldeptgu@satyam.net.in
Avani
G
G
D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D010100:Oxygen / Q000378:metabolism; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000378:metabolism; D013687:Telencephalon / Q000187:drug effects
D005609:Free Radicals; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D005978:Glutathione; D001151:Arsenic; D010100:Oxygen