Transfer of insulin lispro across the human placenta.
Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48 +/- microU in the maternal artery and 28 +/- 1 microU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836 +/- 220 microU.
Holcberg
Gershon
G
Tsadkin-Tamir
Marina
M
Sapir
Olga
O
Wiznizer
Arnon
A
Segal
David
D
Polachek
Hana
H
Ben Zvi
Zvi
Z
D005260:Female; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood*; D061268:Insulin Lispro; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000737:chemistry / Q000378:metabolism*; D011247:Pregnancy
D007328:Insulin; D061268:Insulin Lispro