p-O-geranylcoumaric acid from Melicope lunu-ankenda.
Leaf extracts of Melicope lunu-ankenda were chemically studied and found to contain mixtures of hydrocarbons and squalene, fatty acids and esters. A geranylated coumaric acid was isolated as the major compound. The crude dichloromethane and methanol extracts of the leaves were found to be strongly larvicidal with LC50 values below 20 microg mL(-1). This is a first isolation of p-O-geranylcoumaric acid from this plant.
Ramli
I
I
Department of Chemistry, Faculty of Science & Environmental Studies, University Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Kamarulzaman
N H
NH
Shaari
K
K
Ee
G C L
GC
D000330:Aedes / Q000187:drug effects; D000818:Animals; D003373:Coumaric Acids / Q000737:chemistry / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D027821:Rutaceae
C489875:4-O-geranylcoumaric acid; D003373:Coumaric Acids; D010936:Plant Extracts