title: Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to Helicobacter pylori.
abstract: BACKGROUND
  Recent studies have suggested that there might be an etiologic role for Helicobacter pylori (HP) in rosacea. HP is a Gram-negative bacterium that colonizes the gastric mucosa, increases the generation of reactive oxygen species (ROS), and decreases plasma antioxidants such as ascorbic acid.
  
  
  OBJECTIVE
  To investigate plasma ROS activities and antioxidant status, and their relationship with HP infection, in rosacea patients.
  
  
  METHODS
  Twenty-nine rosacea patients and 20 age- and sex-matched healthy controls were examined for specific immunoglobulin G (IgG) and IgM against HP, plasma malondialdehyde (MDA), and antioxidant potential (AOP) levels.
  
  
  RESULTS
  Compared with controls, the seropositivity of HP for IgM was significantly higher (P = 0.03) and the seropositivity of HP for IgG was significantly lower (P = 0.0001) in patients with rosacea. Plasma MDA levels were higher (P = 0.0001) and AOP levels were lower (P = 0.019) in patients than in controls, regardless of the severity of the disease. Plasma MDA and AOP levels were not affected by the seropositivity of HP for IgM and/or IgG in either group.
  
  
  CONCLUSIONS
  Our results suggest that rosacea is an oxidative stress condition, as reflected by the increased ROS activity and decreased AOP, regardless of HP infection.
authors.affiliation: Department of Dermatology, University of Mersin School of Medicine, Mersin, Turkey. drkbaz@hotmail.com
authors.forename: Kiymet
authors.initials: K
authors.lastname: Baz
authors.forename: M Y Burak
authors.initials: MY
authors.lastname: Cimen
authors.forename: Aysin
authors.initials: A
authors.lastname: Kokturk
authors.forename: Gonul
authors.initials: G
authors.lastname: Aslan
authors.forename: Guliz
authors.initials: G
authors.lastname: Ikizoglu
authors.forename: D Deniz
authors.initials: DD
authors.lastname: Demirseren
authors.forename: Arzu
authors.initials: A
authors.lastname: Kanik
authors.forename: Ugur
authors.initials: U
authors.lastname: Atik
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000097:blood*; D012393:Rosacea / Q000097:blood / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species