title: Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation.
abstract: This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.
authors.affiliation: Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Healey
authors.forename: Steven Z
authors.initials: SZ
authors.lastname: Pavletic
authors.forename: Jinan
authors.initials: J
authors.lastname: Al-Omaishi
authors.forename: M Patricia
authors.initials: MP
authors.lastname: Leuschen
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Pirruccello
authors.forename: Mary L
authors.initials: ML
authors.lastname: Filipi
authors.forename: Charles
authors.initials: C
authors.lastname: Enke
authors.forename: Mary Margaret
authors.initials: MM
authors.lastname: Ursick
authors.forename: Francis
authors.initials: F
authors.lastname: Hahn
authors.forename: J D
authors.initials: JD
authors.lastname: Bowen
authors.forename: Richard A
authors.initials: RA
authors.lastname: Nash
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*; D009460:Neurologic Examination; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D007074:Immunoglobulin G