[Case of inflammatory vasculopathy and encephalopathy caused by treatment with tacrolimus].
The case of inflammatory vasculopathy and encephalopathy caused by treatment with tacrolimus is reported. This 49-year-old woman developed progressive gait ataxia and right-sided hemiparesis after 7 years of tacrolimus therapy for focal sclerosing glomerulonephritis. MRI presented multifocal cerebral lesions with contrast enhancement. Oligoclonal banding was positive. When the treatment with tacrolimus was stopped, the clinical symptoms resolved completely and the MRI findings improved with corticoid monotherapy.
Ringelstein
Adrian
A
Neurologische Klinik mit klinischer Neuro physiologie, Alfried Krupp-Krankenhaus, Essen. neurologie@krupp-krankenhaus.de
Bongs
Katja
K
Sorge-Hädicke
Burkhard
B
Berlit
Peter
P
D004660:Encephalitis / Q000139:chemically induced* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use*; D020293:Vasculitis, Central Nervous System / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control*
D007166:Immunosuppressive Agents; D016559:Tacrolimus