[Outcome of the long-term isolation on the development of allergic reactions in humans].
Studied were consequences of long-term isolation in airtight environment for development of the type-I (IgE-antibodies production) and type-IV (involvement of sensibilized T-lymphocytes) allergic reactions in humans. No significant changes in total IgE, specific IgE-antibodies for domestic, epidermal, fungal, grass pollen and food-borne allergens or serum IL-4 level were found in the period of the 240-d isolation with the microclimate and atmospheric parameters within their normal variations, and on completion of the experiment. Yet, after 3 mos. in isolation all subjects exhibited inhibited leukocyte migration in the presence of tuberculin. These findings bear witness to an activation of sensibilized lymphocytes known as effectors of delayed hypersensitivity.
Rykova
M P
MP
Gertsik
Iu G
IuG
Antropova
E N
EN
Buravkova
L B
LB
Meshkov
D O
DO
D000328:Adult; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000097:blood* / Q000209:etiology; D006969:Hypersensitivity, Immediate / Q000097:blood* / Q000209:etiology; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008875:Middle Aged; D013026:Space Flight; D018561:Space Simulation / Q000009:adverse effects*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D013997:Time Factors
D015847:Interleukin-4; D007073:Immunoglobulin E