title: Transfer of insulin lispro across the human placenta.
abstract: Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48 +/- microU in the maternal artery and 28 +/- 1 microU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836 +/- 220 microU.
authors.forename: Gershon
authors.initials: G
authors.lastname: Holcberg
authors.forename: Marina
authors.initials: M
authors.lastname: Tsadkin-Tamir
authors.forename: Olga
authors.initials: O
authors.lastname: Sapir
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznizer
authors.forename: David
authors.initials: D
authors.lastname: Segal
authors.forename: Hana
authors.initials: H
authors.lastname: Polachek
authors.forename: Zvi
authors.initials: Z
authors.lastname: Ben Zvi
mesh_terms: D005260:Female; D006801:Humans; D007328:Insulin / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood*; D061268:Insulin Lispro; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000737:chemistry / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D007328:Insulin; D061268:Insulin Lispro