title: Immunolocalization of vascular endothelial growth factor in rat condylar cartilage during postnatal development.
abstract: It is well known that angiogenesis is essential for the replacement of cartilage by bone during skeletal growth and regeneration. To address angiogenesis of endochondral ossification in the condyle, we examined the appearance of vascular endothelial growth factor (VEGF) and its receptor Flt-1 in condylar cartilage of the growing rat. The early expression of VEGF at various sites during condylar cartilage development indicates that VEGF plays a role in the regulation of angiogenesis at each site of bone formation. From the findings of Flt-1 immunoreactivity, the VEGF produced by the chondrocytes of the hypertrophic zone should contribute to the promotion of endothelial cell proliferation and to stimulate migration and activation of osteoclasts in condylar cartilage, resulting in the invasion of these cells into the mineralized zone.
authors.affiliation: Department of Orthodontics and Craniofacial Developmental Biology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, 734-8553 Hiroshima, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Aoyama
authors.forename: Eiji
authors.initials: E
authors.lastname: Tanaka
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Miyauchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Takata
authors.forename: Koichi
authors.initials: K
authors.lastname: Hanaoka
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hattori
authors.forename: Akiko
authors.initials: A
authors.lastname: Sasaki
authors.forename: Mineo
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tanne
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002356:Cartilage / Q000254:growth & development / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D008335:Mandibular Condyle / Q000254:growth & development / Q000378:metabolism*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D040281:Vascular Endothelial Growth Factor Receptor-1