Phospholipid profile in tracheal aspirates of very preterm neonates: effect of prenatal betamethasone administration.
We compared the phospholipid profile in tracheal aspirates from surfactant-treated preterm neonates with and without prenatal betamethasone administration. We found higher phosphatidylglycerol concentrations and lower phosphatidylinositol and sphingomyelin concentrations in corticosteroid-treated preterms ( P < 0.01). We speculate that prenatal corticosteroids enhance biochemical surfactant phospholipid maturation.
Landmann
Eva
E
University Children's Hospital, Giessen, Germany. eva.landmann@paediat.med.uni-giessen.de
Weller
Eberhard
E
Stoll-Becker
Simone
S
Gortner
Ludwig
L
D001623:Betamethasone / Q000008:administration & dosage*; D005260:Female; D005865:Gestational Age; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010715:Phosphatidylglycerols / Q000032:analysis; D010716:Phosphatidylinositols / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy; D013109:Sphingomyelins / Q000032:analysis; D013396:Suction; D014132:Trachea / Q000737:chemistry*
D005938:Glucocorticoids; D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; D010743:Phospholipids; D011663:Pulmonary Surfactants; D013109:Sphingomyelins; D001623:Betamethasone