title: [Effect of quercetin on the acyclovir intestinal absorption].
abstract: OBJECTIVE
  To study the effect of quercetin on acyclovir intestinal absorption.
  
  
  METHODS
  The everted gut sac and in vitro intestinal absorption tests were performed. The acyclovir transport quantity was determined by HPLC method.
  
  
  RESULTS
  The everted gut sac study showed that quercetin significantly inhibited the function of intestinal P-glycoprotein   P-gp  . The acyclovir transport quantities from mucosa to serosa space, which incubated with 5, 10, 80 mg/L quercetin solution or 10 mg/L verapamil solution, were increased 0.3, 0.6, 1.0 and 1.0-fold higher than acyclovir alone, respectively. The transport quantity caused by inhibition of intestinal P-gp function fitted with Boltzmann equation. The in vitro intestinal absorption test indicated that the transported acyclovir from serosa to mucosa, incubated with 2, 5, 10 mg/L quercetin solution, was significantly decreased compared with acyclovir alone.
  
  
  CONCLUSIONS
  Quercetin can enhance acyclovir intestinal absorption by inhibiting the function of P-gp.
authors.affiliation: Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
authors.forename: Zhao-gang
authors.initials: ZG
authors.lastname: Yang
authors.forename: Huan
authors.initials: H
authors.lastname: Meng
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Li
authors.forename: Wan-liang
authors.initials: WL
authors.lastname: Lv
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors* / Q000502:physiology; D000212:Acyclovir / Q000493:pharmacokinetics*; D000818:Animals; D001692:Biological Transport; D002851:Chromatography, High Pressure Liquid; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D011794:Quercetin; D000212:Acyclovir