title: Whipple's disease with neurological manifestations: case report.
abstract: Whipple's disease (WD) is an uncommon multisystem condition caused by the bacillus Tropheryma whipplei. Central nervous system involvement is a classical feature of the disease observed in 20 to 40% of the patients. We report the case of a 62 year old man with WD that developed neurological manifestations during its course, and discuss the most usual signs and symptoms focusing on recent diagnostic criteria and novel treatment regimens.
authors.affiliation: Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil. mcfjunior@ig.com.br
authors.forename: Marcondes C
authors.initials: MC
authors.lastname: França
authors.forename: Rafael de
authors.initials: Rd
authors.lastname: Castro
authors.forename: Márcio Luiz F
authors.initials: ML
authors.lastname: Balthazar
authors.forename: George Linard S
authors.initials: GL
authors.lastname: Malveira
authors.forename: Clodoaldo
authors.initials: C
authors.lastname: Pirani
authors.forename: Leonardo
authors.initials: L
authors.lastname: Deus-Silva
authors.forename: Alexandre R da
authors.initials: AR
authors.lastname: Paz
authors.forename: Luciano S
authors.initials: LS
authors.lastname: Queiroz
authors.forename: Benito P
authors.initials: BP
authors.lastname: Damasceno
mesh_terms: D001706:Biopsy; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011115:Polyneuropathies / Q000175:diagnosis / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D008061:Whipple Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination