Localization of beta-defensin genes in non human primates.
Defensins are a family of host defence peptides that play an important role in the innate immunity of mammalian and avian species. In humans, four beta-defensins have been isolated so far, corresponding to the products of the genes DEFB1 (h-BD1, GenBank accession number NM_005218); DEFB4 (h-Bd2, NM_004942.2), DEFB103 (h-BD3, NM_018661); and DEFB104 (hBD4, NM_080389) mapping on chromosome 8p23.22. We have localized beta-defensin genes on metaphasic chromosomes of great apes and several non-human primate species to determine their physical mapping. Using fluorescent in situ hybridization and BAC probes containing the four beta-defensin genes, we have mapped the homologous regions to the beta-defensin genes on chromosome 8p23-p.22 in non-human primates, while no signals were detected on prosimians chromosomes.
Ventura
M
M
Boniotto
M
M
Pazienza
M
M
Palumbo
V
V
Cardone
M F
MF
Rocchi
M
M
Tossi
A
A
Amoroso
A
A
Crovella
S
S
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D000882:Haplorhini; D015186:Hominidae; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D011323:Primates / Q000235:genetics*; D023083:beta-Defensins / Q000235:genetics*
D023083:beta-Defensins