title: [New developments in skin replacement materials].
abstract: Current treatment strategies in intensive care medicine permit survival of patients with burns of more than 80% of the total body surface area (TBSA). Major burns result in extensive skin defects. Thus, burn victims often suffer from scar contractures, altered thermoregulation, and unsatisfactory cosmetic results. In addition to the well-established cultivated epithelial autografts, a number of new composite grafts have been developed in the field of tissue engineering. The combination of synthetic and allogenic matrix structures together with an allogenic or autologous epithelium allows the possibility of mimicking skin structure. The aim is to achieve improved wound healing by regeneration of dermal tissue instead of scarring. This article provides an overview of the currently available products which have already been introduced into clinical routine as well as describing advantages and disadvantages of the individual products and their indications.
authors.affiliation: BG Unfallklinik Ludwigshafen, Klinik für Hand-, Plastische und Rekonstruktive Chirurgie-Schwerbrandverletztenzentrum, Plastische- und Handchirurgie der Universität Heidelberg, Ludwigshafen. przybilski @bgu-ludwigshafen.de
authors.forename: M
authors.initials: M
authors.lastname: Przybilski
authors.forename: R
authors.initials: R
authors.lastname: Deb
authors.forename: D
authors.initials: D
authors.lastname: Erdmann
authors.forename: G
authors.initials: G
authors.lastname: Germann
mesh_terms: D001684:Biological Dressings; D002056:Burns / Q000601:surgery*; D006801:Humans; D015603:Keratinocytes / Q000637:transplantation*; D016038:Skin Transplantation; D017768:Skin, Artificial; D023822:Tissue Engineering; D014945:Wound Healing / Q000502:physiology