title: Production of leucinostatins and nematicidal activity of Australian isolates of Paecilomyces lilacinus (Thom) Samson.
abstract: OBJECTIVE
  To evaluate the relationship between leucinostatin production by Paecilomyces lilacinus isolates and their biological activities.
  
  
  RESULTS
  The nematicidal, parasitic and enzymatic activity of Australian P. lilacinus isolates were investigated. Nematicidal activities of culture filtrates were measured by mortality and inhibition of reproduction of Caenorhabditis elegans, whereas egg-parasitic activity was measured by colonization on Meloidogyne javanica. Enzymatic activities (protease and chitinase) were assayed on solid media. The results suggest that leucinostatins in P. lilacinus are indicators of nematicidal activity, whereas chitinase activity might be related to parasitism.
  
  
  CONCLUSIONS
  Nematicidal activity of culture filtrates of Paecilomyces lilacinus strains related to their ability to produce leucinostatins.
  
  
  CONCLUSIONS
  This is the first study describing the leucinostatins as nematicides.
authors.affiliation: Soil Science and Plant Nutrition, The University of Western Australia, Crawley, Western Australia, Australia.
authors.forename: J O
authors.initials: JO
authors.lastname: Park
authors.forename: J R
authors.initials: JR
authors.lastname: Hargreaves
authors.forename: E J
authors.initials: EJ
authors.lastname: McConville
authors.forename: G R
authors.initials: GR
authors.lastname: Stirling
authors.forename: E L
authors.initials: EL
authors.lastname: Ghisalberti
authors.forename: K
authors.initials: K
authors.lastname: Sivasithamparam
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides; D017173:Caenorhabditis elegans / Q000254:growth & development*; D002688:Chitinases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D009183:Mycotoxins / Q000096:biosynthesis / Q000633:toxicity; D010143:Paecilomyces / Q000254:growth & development / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism* / Q000633:toxicity; D010572:Pest Control, Biological / Q000379:methods; D014431:Tylenchoidea / Q000382:microbiology*
chemical_list: D023181:Antimicrobial Cationic Peptides; D005656:Fungal Proteins; D009183:Mycotoxins; D010455:Peptides; C008268:leucinostatin A; D002688:Chitinases; D010450:Endopeptidases