4'-alpha-C-Branched N,O-nucleosides: synthesis and biological properties.
The synthesis of 4'-alpha-C-branched N,O-nucleosides has been described, based on the 1,3-dipolar cycloaddition of nitrones with vinyl acetate followed by coupling with silylated nucleobases, The obtained compounds have been evaluated for their activity against HSV-1, HSV-2, HTLV-1. Cytotoxicity and apoptotic activity have been also investigated: compound 10c shows moderate apoptotic activity in Molt-3 cells.
Chiacchio
Ugo
U
Dipartimento Scienze Chimiche, Università di Catania, Viale Andrea Doria 6, 95125 Catania, Italy.
Genovese
Filippo
F
Iannazzo
Daniela
D
Piperno
Anna
A
Quadrelli
Paolo
P
Antonino
Corsaro
C
Romeo
Roberto
R
Valveri
Vincenza
V
Mastino
Antonio
A
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000998:Antiviral Agents; D009705:Nucleosides