[T-cellular energy deficiency in the pathogenesis of immunodeficiency in pulmonary tuberculosis].
The phenotypic and functional properties of T cells were evaluated in patients with tuberculin anergy and a possible role of anergic T cells in the development of immune deficiency in pulmonary tuberculosis (PT) was studied. The profound decrease (more than 50%) depressed T-cell proliferation in PPD-stimulated cultures was shown to be recorded in 44% (59/134) patients with PT. PPD hyporesponsiveness was associated with the low proliferation of anti-CD3 and SEB-stimulated proliferation of a healthy donor's mononuclear cells evidencing the enlargement of anergic T cells with a suppressive activity in PT. A PPD-stimulated response in healthy donors was under the negative control of CG25-positive cells. In the PPD-anergic patients, there was a significant increase in CD4+CD25+ T cells that were inversely correlated with the PPD-induced proliferative response. The development of tuberculin anergy was more pronounced in patients with drug resistance. The intensity of a PPD-stimulated response in patients with tuberculin anergy may be restored in the presence of exogenous interleukin-2.
Sakhno
L V
LV
Tikhonova
M A
MA
Kurganova
E V
EV
Shevela
E Ia
EIa
Nikonov
S D
SD
Zhdanov
O A
OA
Mostovaia
G V
GV
Ostanin
A A
AA
Chernykh
E R
ER
D000328:Adult; D015703:Antigens, CD / Q000187:drug effects / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism*; D014373:Tuberculin / Q000008:administration & dosage / Q000494:pharmacology; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology
D015703:Antigens, CD; D014373:Tuberculin