[A case of anaphylactic shock with tranexamique acid (Exacyl)].
A 72-year-old male patient was scheduled for coronary artery bypass graft surgery because of severe three-vessel disease. Induction of anaesthesia was uneventful. Following bolus infusion of tranexamic acid (Exacyl), the patient presented clinical signs consistent with anaphylactic shock. Surgery was postponed and the patient recovered without sequaelae. Allergological investigations (cutaneous tests, serum IgE concentrations, in vitro histamine-release tests) suggest that this is the first reported case of anaphylactic shock to tranexamic acid. Several weeks later, the patient underwent surgery with a similar anaesthetic regimen and the clinical course was uneventful.
Lucas-Polomeni
M-M
MM
Service d'anesthésie-réanimation chirurgicale-II, hôpital Pontchaillou, université Rennes-I, Rennes, France. mmadlp@yahoo.fr
Delaval
Y
Y
Menestret
P
P
Delaval
P
P
Ecoffey
C
C
D000368:Aged; D000707:Anaphylaxis / Q000209:etiology*; D000933:Antifibrinolytic Agents / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000601:surgery; D004342:Drug Hypersensitivity / Q000175:diagnosis; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D012882:Skin Tests; D014148:Tranexamic Acid / Q000009:adverse effects*
D000933:Antifibrinolytic Agents; D007073:Immunoglobulin E; D014148:Tranexamic Acid