[Viral inclusions of sarcoid granuloma into the epitheliocytes].
Electron microscopy was used study the cellular composition of sarcoid granulomas in the lung of 10 patients. In 4 patients, epithelioid cells contained herpes virus virions. In these patients, the disease clinically began acutely, ran along with erythema nodosum; their treatment involved glucocorticosteroids. In the other patients, the cells of sarcoid granulomas did not contain viruses, the granulomas were at the fibrosing stage; diffuse pneumosclerosis was clinically diagnosed. It is suggested that in sarcoidosis, immunity is of not sterile character and the phagocytosis of virus aggregates with epithelioid cells demonstrates the degree of endocytobiosis. This process takes place in tuberculosis, which is a manifestation of the biological expediency of endocytobiosis as this allows infection immunity to be maintained.
Paukov
V S
VS
Ugriumov
A I
AI
Borisov
S E
SE
Solov'eva
I P
IP
Kupavtseva
E A
EA
D004847:Epithelial Cells / Q000473:pathology / Q000821:virology; D006105:Granulomatous Disease, Chronic / Q000150:complications / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D002479:Inclusion Bodies / Q000821:virology*; D008168:Lung / Q000473:pathology / Q000821:virology; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000821:virology*; D023981:Sarcoma, Myeloid / Q000150:complications / Q000473:pathology / Q000821:virology; D018139:Simplexvirus / Q000302:isolation & purification