[Water balance and pharmacokinetics of ketamine during anesthesia in roentgen-endovascular procedures in children].
Forty-seven children, aged 2 to 12, with different pathologies, who underwent the abdominal aortography with the bolus introduction of 60% verografin, i.e. a radiopaque contrast agent (RCA), 2-3 ml/kg for 2-3 sec. The osmolar index of blood went up sharply, diuresis increased 7-fold and the aldosterone content topped 2-fold the original level. Simultaneously, the plasma concentration of ketamine was reducing by 2 times faster than in children who were not administered RCA. An additional introduction of an anesthetic made on minute 3 after RCA injection was suggested to modify the anesthesia management scheme.
Lazarev
V V
VV
Mikhel'son
V A
VA
Burakov
A A
AA
Izotov
B N
BN
Savchuk
S A
SA
D000768:Anesthesia, General; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D001027:Aortography; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000008:administration & dosage*; D004231:Diuresis; D006801:Humans; D007649:Ketamine / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D009994:Osmolar Concentration; D014882:Water-Electrolyte Balance
D003287:Contrast Media; D007649:Ketamine