Effects of melatonin on plasma S-nitrosoglutathione and glutathione in streptozotocin-treated rats.
The aim of this study was to determine the effects of streptozotocin-induced diabetes on plasma reduced glutathione (GSH) and S-nitrosoglutathione (GSNO) levels. Further, the study investigated whether an antioxidant, pineal hormone melatonin, could protect against STZ-induced effects. STZ significantly decreased plasma GSH but increased the levels of plasma GSNO. Daily supplementation with melatonin restored plasma thiol to control values. Data suggest that STZ-induced hyperglycemia and compounds that act as scavengers of free radicals and peroxynitrite like melatonin may exert protection against STZ-induced toxicity.
Görgün
F Murat
FM
Department of Biochemistry, Cerrahpaşa School of Medicine, Istanbul University, Istanbul, Turkey. falihmurat@hotmail.com
Kökoğlu
Emine
E
Gümüştaş
M Koray
MK
Altuğ
Tuncay
T
Cansever
Serif
S
Kavunoğlu
Gülsev
G
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D019587:Dietary Supplements; D005978:Glutathione / Q000097:blood*; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D026422:S-Nitrosoglutathione / Q000097:blood*; D013311:Streptozocin
D000975:Antioxidants; D026422:S-Nitrosoglutathione; D013311:Streptozocin; D005978:Glutathione; D008550:Melatonin