title: Synthesis of 1-(omega-aminoalkyl)naphthoindolediones with antiproliferative properties.
abstract: The preparation and cytotoxic properties of 4,11-dihydroxynaphtho[2,3-f]indole-5,10-dione derivatives carrying N-aminoalkyl substituents are described. The N-aminobutylnaphthoindolediones obtained were studied in National Cancer Institute Screening Program and demonstrated high antiproliferative activity against 60 human cancer cell lines. All N-(4-aminobutyl) derivatives have higher potency than adriamycin or mitoxantrone against adriamycin selected multidrug resistant breast cancer cell line NCI/ADR.
authors.affiliation: Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirogovskaya, 11, Moscow 119021, Russia. mnp@space.ru
authors.forename: Andrey E
authors.initials: AE
authors.lastname: Shchekotikhin
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Buyanov
authors.forename: Maria N
authors.initials: MN
authors.lastname: Preobrazhenskaya
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009284:Naphthols / Q000138:chemical synthesis* / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000970:Antineoplastic Agents; D009284:Naphthols