[Effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis].
OBJECTIVE
To study the effect of helicobacter pylori on gastric mucosal cell proliferation in gastritis.


METHODS
Fifty-six gastritis patients with or without Helicobacter pylori infection (Hp+ 27; Hp- 29) were selected. The expression of proliferation cell nuclear antigen (PCNA), epidermal growth factor receptor (EGFR), transforming growth factor beta receptor type I and type II(TGFbetaRI, TGFbetaRII) in gastric mucosa were examined by immunohistochemical method.


RESULTS
The PCNA and EGFR were significantly higher in Hp positive chronic gastritis patients than in Hp negative ones(P<0.05); The TGFbetaRI(P=0.16) and TGFbetaRII(P=0.97) were lower.


CONCLUSIONS
Hp infection promotes over  proliferation of gastric mucosal cells.
Liu
Zheng-xin
ZX
Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China. liuzhengx2003@vip.sina.com
Chen
Bao-wen
BW
Yang
Gui-bin
GB
Zhang
Xi-quan
XQ
Jia
Bo-qi
BQ
D030201:Activin Receptors, Type I / Q000032:analysis; D000328:Adult; D000368:Aged; D002455:Cell Division; D066246:ErbB Receptors / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis; D016481:Helicobacter Infections / Q000378:metabolism / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis
D018809:Proliferating Cell Nuclear Antigen; D018125:Receptors, Transforming Growth Factor beta; D066246:ErbB Receptors; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II