Early complement activation increases in the brain in some aged normal subjects.
Complement activation is increased in Alzheimer's disease (AD) and may contribute to the development and progression of this disorder. To compare early complement activation between normal and AD brain specimens, C4d and iC3b concentrations were measured in hippocampus, entorhinal cortex, temporal cortex, parietal cortex, and cerebellum from aged normal and AD subjects n=10-14 for both), and in hippocampus and entorhinal cortex from younger normal subjects (n=5-6). C4d and iC3b levels increased 2.3- to 4.6-fold in AD versus aged normal specimens (all P <0.05), with lowest concentrations of these activation proteins generally in cerebellum. No significant differences were present between aged and younger normal C4d and iC3b levels in hippocampus or entorhinal cortex. However, the concentrations of these proteins were markedly increased in several aged normal specimens. Normal subject age was moderately associated with both C4d (r=0.49) and iC3b (r=0.53) concentrations in the hippocampus. Increased brain complement activation in some elderly individuals may promote the subsequent development of AD.
Loeffler
David A
DA
Division of Neurology, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA. DLoeffler@beaumont.edu
Camp
Dianne M
DM
Schonberger
Michael B
MB
Singer
Daniel J
DJ
LeWitt
Peter A
PA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology* / Q000378:metabolism; D000544:Alzheimer Disease / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D001921:Brain / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D003179:Complement C3b / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D015935:Complement C4b; D003165:Complement System Proteins / Q000276:immunology* / Q000378:metabolism; D004660:Encephalitis / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D018728:Entorhinal Cortex / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D006624:Hippocampus / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D012016:Reference Values; D015854:Up-Regulation / Q000502:physiology*
D003181:Complement C4; D010446:Peptide Fragments; D003179:Complement C3b; D015935:Complement C4b; C032261:complement C4d; D003165:Complement System Proteins