Bioadhesive topical application of tryptophan derivatives.
Innovative formulations with high affinity for biological substrates can be designed by exploiting the TVS tensiometric versus skin approach. Combining a compressed air continous-spray application system with biomimetic agents modulating the epidermal barrier (badsystem), bioadhesive topical application of tryptophan derivatives are well obtained without side effects. The biomimetic effect of tryptophan-badsystem was observed.
Bettero
Antonio
A
Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo 5, I-35131 Padova, Italy. antonio.bettero@unipd.it
Dal Bosco
Camilla
C
Gregorio
Michela
M
D000269:Adhesives / Q000008:administration & dosage*; D000287:Administration, Topical; D004341:Drug Evaluation; D006801:Humans; D014364:Tryptophan / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000269:Adhesives; D014364:Tryptophan