title: Update on progressive supranuclear palsy.
abstract: A better understanding of the challenges in the diagnosis of progressive supranuclear palsy (PSP), the most common atypical parkinsonian neurodegenerative disorder, has led to improving its diagnostic accuracy. Similarly, a better understanding of the role of tau mutations, mitochondrial complex I inhibitors, oxidative injury, and inflammation in neurodegeneration has led to an unraveling of potential risk factors for the development of PSP. These advances are explained in detail in this review.
authors.affiliation: Movement Disorder Program, Department of Neurology, University of Louisville School of Medicine, A Building, Room 113, 500 South Preston Street, Louisville, KY 40202, USA. i.litvan@louisville.edu
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging / Q000639:trends; D006801:Humans; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*