Evidence of Helicobacter pylori infection in dental plaque and gastric mucosa.
OBJECTIVE
To determine the presence of Helicobacter pylori (H. pylori ) in dental plaque of individuals suffering from H. pylori associated gastric disease.


METHODS
descriptive.


METHODS
The study was conducted at the Department of Medicine in collaboration with Departments of Dentistry and Pathology at PNS Shifa, Karachi during a period extending from July 1998 to June 1999.


METHODS
Patients presenting with symptoms/signs of chronic gastritis were included in the study. Specimens of dental plaque and gastric biopsy were collected from all the patients. The dental plaque specimen was processed for helicourease test and the gastric biopsy specimens were processed both for the helicourease test and histopathology.


RESULTS
Out of all patients studied (n=52), 32 (61.53%) were positive for helicourease test with gastric biopsy while 48 (92.30%) were positive with dental plaque. The histopathology of gastric biopsy showed H. pylori associated chronic active gastritis in 42 (80.76%) patients. Eight (15.38%) patients showed chronic active gastritis which was not associated with H. pylori while in 2 (3.84%) patients the gastric biopsy specimen was unremarkable.


CONCLUSIONS
Majority of the patients have possible H. pylori colonization in dental plaque while about two-thirds have H. pylori associated chronic active gastritis. Oral cavity may be the first place for colonization and then the infection involves the gastric mucosa.
Siddiq
Masood
M
Department of Gastroenterology Medicine, Military Hospital, Rawalpindi. drmasood@comsat.net.pk
Haseeb-ur-Rehman
Mahmood
Abid
A
D000328:Adult; D002908:Chronic Disease; D003773:Dental Plaque / Q000382:microbiology*; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology*; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000635:transmission*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged