title: Comparison of survival following coronary artery bypass grafting vs. percutaneous coronary intervention in diabetic and non-diabetic patients: retrospective cohort study of 6320 procedures.
abstract: OBJECTIVE
  To determine whether mortality following percutaneous coronary intervention vs. coronary bypass grafting varies according to whether or not patients have diabetes.
  
  
  METHODS
  We used the Scottish Coronary Revascularization Register to identify all patients undergoing revascularization in Scottish NHS hospitals since 1997. We excluded single-vessel disease, left main stem stenosis, and bypass grafting performed at the same time as other operations. We used death certificate data from the Registrar General to identify all subsequent deaths.
  
  
  RESULTS
  Of the 6320 eligible procedures, 5042 (80%) were bypass grafts and 1278 (20%) angioplasties. Overall 831 (13%) patients had diabetes with no significant difference by procedure (13% vs. 12%). A total of 382 deaths occurred over a mean follow-up of 2.3 years. Diabetic patients had a poorer prognosis following both surgery (adjusted hazards ratio (HR) 1.43, 95% confidence interval (CI) 1.08, 1.89) and percutaneous intervention (adjusted HR 2.58, 95% CI 1.43, 4.63). Among non-diabetic patients, no significant differences in mortality were detected between the two procedures. Among diabetic patients, no significant difference was detected in those with two-vessel disease. In those with impaired left ventricular function and triple-vessel disease, angioplasty was associated with a significantly higher risk of death (adjusted HR 3.58, 95% CI 1.40, 9.19).
  
  
  CONCLUSIONS
  This is the first study to demonstrate statistically significant results that support the BARI trial findings. Our study demonstrated a significant difference for triple-vessel disease but not two-vessel disease. The former may be due to incomplete revascularization using percutaneous intervention. Our results require corroboration from randomized trials.
authors.affiliation: Greater Glasgow NHS Board, Dalian House, 350 St Vincents Street, Glasgow G3 8YU, Scotland, UK. jill.pell@gghb.scot.nhs.uk
authors.forename: J P
authors.initials: JP
authors.lastname: Pell
authors.forename: A C H
authors.initials: AC
authors.lastname: Pell
authors.forename: R R
authors.initials: RR
authors.lastname: Jeffrey
authors.forename: K
authors.initials: K
authors.lastname: Jennings
authors.forename: K
authors.initials: K
authors.lastname: Oldroyd
authors.forename: H
authors.initials: H
authors.lastname: Eteiba
authors.forename: K J
authors.initials: KJ
authors.lastname: Hogg
authors.forename: A
authors.initials: A
authors.lastname: Murday
authors.forename: A
authors.initials: A
authors.lastname: Faichney
authors.forename: I
authors.initials: I
authors.lastname: Colquhoun
authors.forename: G
authors.initials: G
authors.lastname: Berg
authors.forename: I R
authors.initials: IR
authors.lastname: Starkey
authors.forename: A
authors.initials: A
authors.lastname: Flapan
authors.forename: P
authors.initials: P
authors.lastname: Mankad
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000401:mortality; D001026:Coronary Artery Bypass / Q000401:mortality; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D003925:Diabetic Angiopathies / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012606:Scotland / Q000453:epidemiology