title: Transamination reactions with multiple turnovers catalyzed by hydrophobic pyridoxamine cofactors in the presence of polyethylenimine polymers.
abstract: Pyridoxamines carrying hydrophobic side chains reversibly bind into the hydrophobic core of polyethylenimines and transaminate ketoacids to amino acids with as much as a 725000-fold rate acceleration. Turnover catalysis was achieved by sacrificial oxidative decarboxylation of C-substituted amino acids, which reconverted the pyridoxals to pyridoxamines.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhou
authors.forename: Jason
authors.initials: J
authors.lastname: Chruma
authors.forename: Ronald
authors.initials: R
authors.lastname: Breslow
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011733:Pyridoxamine / Q000737:chemistry*; D019289:Pyruvic Acid / Q000737:chemistry; D013379:Substrate Specificity; D000637:Transaminases / Q000737:chemistry*
chemical_list: D011108:Polymers; D011733:Pyridoxamine; D019289:Pyruvic Acid; D011094:Polyethyleneimine; D000637:Transaminases