title: [Dynamic alterations of rat metabolic enzymes activities and liver damage in rat exposed to vinyl chloride monomer].
abstract: OBJECTIVE
  Study the alterations of metabolic enzyme activities and liver functions induced by vinyl chloride monomer(VCM) and to explore the relationship between metabolic enzyme activities and liver functions.
  
  
  METHODS
  Animals were administered VCM for 12 weeks in doses of 0, 5, 10, 20 mg/kg (i.p.), and were victimized at week of 3rd, 6th, 9th, 12th. The activities of enzymes were determined using spectrophotography. The indexes of liver functions were assayed by automatic biochemistry analyzer. The histopathological alterations of rat livers were observed.
  
  
  RESULTS
  The activities of ALDH, CYP2E1, GSTs, were significantly different between groups, in addition, those differences can also be seen with the increase of experiment time. There was negative correlation between ALP and ADH (r = -0.649).
  
  
  CONCLUSIONS
  The degree of liver damage induced by VCM could be associated with the activities of liver metabolic enzymes. It was suggested that there was slight correlation between enzyme activities in serum and enzyme activities in liver.
authors.affiliation: School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Aihong
authors.initials: A
authors.lastname: Wang
authors.forename: Shoumin
authors.initials: S
authors.lastname: Zhu
authors.forename: Yuanling
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yue
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D019392:Cytochrome P-450 CYP2E1 / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity
chemical_list: D014753:Vinyl Compounds; D019392:Cytochrome P-450 CYP2E1; D005982:Glutathione Transferase; D014752:Vinyl Chloride