title: [Spontaneous and mitogen-induced production of proinflammatory cytokines (interleukin-1 and tumor necrosis factor-alpha) in patients with chronic chlamydia infection of urogenital system].
abstract: The article contributes to studying functional activity of mononuclear and macrophage immune cells by spontaneous and induced production of IL-1 and TNF-alpha cytokines in patients with chronic urogenital clamidiosis. The patients with monoinfection were shown to have high level of IL-1 and low level of TNF-alpha, while the patients with mixed infection of urogenital tract presented with the high production of TNF-alpha. The cells activation raise cytokines production not to the level observed among healthy persons. It suggests decreasing compensatory regulation in yet higher activated cells.
authors.forename: V Ie
authors.initials: VIe
authors.lastname: Driians'ka
authors.forename: H M
authors.initials: HM
authors.lastname: Drannik
authors.forename: S M
authors.initials: SM
authors.lastname: Vashchenko
authors.forename: V I
authors.initials: VI
authors.lastname: Fesenkova
authors.forename: V S
authors.initials: VS
authors.lastname: Papakina
mesh_terms: D000328:Adult; D002690:Chlamydia Infections / Q000276:immunology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D002908:Chronic Disease; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology* / Q000382:microbiology; D005832:Genital Diseases, Male / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007375:Interleukin-1 / Q000276:immunology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology
chemical_list: D007375:Interleukin-1; D008934:Mitogens; D014409:Tumor Necrosis Factor-alpha