Antioxidative activity of furanocoumarins isolated from Angelicae dahuricae.
The methylene chloride extract of the root of Angelicae dahuricae showed high protective activity against 2,2'-azobis (2-aminodinopropane) dihydrochloride (AAPH)-induced cellular damage. From this extract, 11 furanocoumarins were isolated, namely oxypeucedanin hydrate, 9-hydroxy-4-methoxypsoralen, byakangelicin, pabulenol, alloisoimperatorin, neobyakangelicol, byakangelicol, oxypeucedanin, imperatorin, phellotorin and isoimperatorin, respectively. Among these 11 furanocoumarins, 9-hydroxy-4-methoxypsoralen and alloisoimperatorin displayed potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro.
Piao
Xiang Lan
XL
College of Pharmacy, Seoul National University, Seoul 151-742, South Korea.
Park
Il Ho
IH
Baek
Seung Hoon
SH
Kim
Hyun Young
HY
Park
Man Ki
MK
Park
Jeong Hill
JH
D000578:Amidines; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D019661:Apiaceae; D001713:Biphenyl Compounds; D002470:Cell Survival / Q000187:drug effects; D011564:Furocoumarins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018374:LLC-PK1 Cells / Q000187:drug effects; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D013552:Swine
D000578:Amidines; D000975:Antioxidants; D001713:Biphenyl Compounds; D011564:Furocoumarins; D010851:Picrates; D010936:Plant Extracts; C046728:2,2'-azobis(2-amidinopropane); C004931:1,1-diphenyl-2-picrylhydrazyl