title: Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development.
abstract: A novel coronavirus has been recently identified as the causative agent of the severe acute respiratory syndrome (SARS) outbreak that has accounted for more than 8000 infected people worldwide. This review will discuss current knowledge on coronavirus replication, pathogenesis, evolution, and vaccine strategies, as well as the most recent findings on SARS coronavirus.
authors.affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.
authors.forename: Sonia R
authors.initials: SR
authors.lastname: Navas-Martín
authors.forename: Susan
authors.initials: S
authors.lastname: Weiss
mesh_terms: D000818:Animals; D006801:Humans; D045473:Severe acute respiratory syndrome-related coronavirus / Q000254:growth & development* / Q000472:pathogenicity*; D045169:Severe Acute Respiratory Syndrome / Q000517:prevention & control* / Q000821:virology*; D014765:Viral Vaccines; D014774:Virulence
chemical_list: D014765:Viral Vaccines