title: Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones.
abstract: Recent studies have shown that C-reactive proteins have a pathogenetic role in atherothrombosis and concentrations of these substances could be used as a marker for future vascular events. The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP) in individuals with atherothrombotic risk factors and apparently healthy ones. We have presently matched 469 females and 469 males having the same age and body mass index (BMI). Of these, 210 men and 210 women had no atherothrombotic risk factors. In this group the hs-CRP concentrations were 1.6+/-3.4 mg l(-1) in women and 1.0+/-2.7 mg l(-1) in men (p<0.0005). These values were 2.1+/-3.4 mg l(-1) and 1.5+/-2.8 mg l(-1), respectively, in the entire cohort (p<0.0005), which included also individuals with atherothrombotic risk factors. We conclude that significant gender differences exist in hs-CRP concentrations despite perfect matching for age and BMI. These differences should be reflected in guidelines that suggest hs-CRP cut-off points for the stratification of vascular risk.
authors.affiliation: Department of Internal Medicine D Tel-Aviv Sourasky Medical Center 6 Weizman Street Tel Aviv 64239, Israel.
authors.forename: Ori
authors.initials: O
authors.lastname: Rogowski
authors.forename: David
authors.initials: D
authors.lastname: Zeltser
authors.forename: Itzhak
authors.initials: I
authors.lastname: Shapira
authors.forename: Michael
authors.initials: M
authors.lastname: Burke
authors.forename: Vera
authors.initials: V
authors.lastname: Zakut
authors.forename: Tamar
authors.initials: T
authors.lastname: Mardi
authors.forename: Einor
authors.initials: E
authors.lastname: Ben-Assayag
authors.forename: Jack
authors.initials: J
authors.lastname: Serov
authors.forename: Meirav
authors.initials: M
authors.lastname: Rozenblat
authors.forename: Shlomo
authors.initials: S
authors.lastname: Berliner
mesh_terms: D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology*; D015415:Biomarkers; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000096:biosynthesis*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein