title: Acute myocardial infarction: tissue characterization with T1rho-weighted MR imaging--initial experience.
abstract: Acute myocardial injury was evaluated in 21 patients by using a contrast material-enhanced T1rho-weighted cine turbo field-echo magnetic resonance (MR) imaging sequence and a delayed-enhancement sequence. In 12 of 21 patients, conventional T1-weighted contrast-enhanced cine turbo field-echo MR images were also collected for direct comparison with T1rho-weighted images. Delayed-enhancement technique distinctly characterized irreversible injury (percentage enhancement, 588% +/- 344). With T1rho weighting, percentage enhancement of irreversibly injured myocardium was 68% +/- 41, compared with 23% +/- 24 without T1rho weighting (P <.006). The addition of T1rho weighting to contrast-enhanced cine turbo field-echo MR sequences may offer a new contrast enhancement mechanism for characterization of acutely infarcted myocardium.
authors.affiliation: Philips Medical Systems, Cleveland, Ohio, USA. raja.muthupillai@philips.com
authors.forename: Raja
authors.initials: R
authors.lastname: Muthupillai
authors.forename: Scott D
authors.initials: SD
authors.lastname: Flamm
authors.forename: James M
authors.initials: JM
authors.lastname: Wilson
authors.forename: Roderic I
authors.initials: RI
authors.lastname: Pettigrew
authors.forename: W Thomas
authors.initials: WT
authors.lastname: Dixon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D004562:Electrocardiography; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis; D009206:Myocardium / Q000473:pathology*; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA