title: Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice.
abstract: Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 6006, Cincinnati, OH 45267-0564, USA. gee.lau@uc.edu
authors.forename: Gee W
authors.initials: GW
authors.lastname: Lau
authors.forename: Huimin
authors.initials: H
authors.lastname: Ran
authors.forename: Fansheng
authors.initials: F
authors.lastname: Kong
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Hassett
authors.forename: Dimitri
authors.initials: D
authors.lastname: Mavrodi
mesh_terms: D000818:Animals; D008168:Lung / Q000382:microbiology* / Q000473:pathology; D008171:Lung Diseases / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D011710:Pyocyanine / Q000235:genetics / Q000378:metabolism*
chemical_list: D011710:Pyocyanine