title: [A case of combined hepatocellular-cholangiocarcinoma with sarcomatous transformation and second primary colon cancer].
abstract: Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reactions for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7.
authors.affiliation: Department of Internal Medicine, College of Medicine, Pochon CHA University, Korea.
authors.forename: Jae Hi
authors.initials: JH
authors.lastname: Kim
authors.forename: Yong Gu
authors.initials: YG
authors.lastname: Lee
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: Cheol Kweon
authors.initials: CK
authors.lastname: Jung
authors.forename: Hyeong Tae
authors.initials: HT
authors.lastname: Kim
authors.forename: Haeyoun
authors.initials: H
authors.lastname: Kang
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Kho
authors.forename: Sung Pyo
authors.initials: SP
authors.lastname: Hong
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Pil Won
authors.initials: PW
authors.lastname: Park
authors.forename: Gyu Sung
authors.initials: GS
authors.lastname: Rim
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*