title: Fluorinated quinoid inhibitor: possible "pure" arylator predicted by the simple theoretical calculation.
abstract: We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.
authors.affiliation: Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
authors.forename: Seung Wook
authors.initials: SW
authors.lastname: Ham
authors.forename: Jong-In
authors.initials: JI
authors.lastname: Choe
authors.forename: Mei-Fang
authors.initials: MF
authors.lastname: Wang
authors.forename: Vincent
authors.initials: V
authors.lastname: Peyregne
authors.forename: Brian I
authors.initials: BI
authors.lastname: Carr
mesh_terms: D016227:Benzoquinones / Q000138:chemical synthesis / Q000494:pharmacology; D005459:Fluorides / Q000037:antagonists & inhibitors; D006873:Hydroquinones / Q000037:antagonists & inhibitors*; D008962:Models, Theoretical; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D016227:Benzoquinones; D006873:Hydroquinones; D009285:Naphthoquinones; D005459:Fluorides