title: The prevention of type 2 diabetes mellitus: recent advances.
abstract: Diabetes is a major public health problem that is approaching epidemic proportions globally. There is an urgent need for strategies to curb the rising prevalence of this disease, and prevention appears a logical approach. Lifestyle modifications with weight loss and moderate exercise can reduce the incidence of diabetes by >50% in patients with impaired glucose tolerance (IGT). The use of metformin, acarbose and other agents have been shown in randomized prospective trials to prevent type 2 diabetes in high-risk subjects with IGT. Other pharmacological interventions are currently being examined in large prospective studies. It is likely that one or a combination of these approaches could make diabetes prevention a reality in the near future.
authors.affiliation: Department of Diabetes and Endocrinology, University Hospital Aintree, Liverpool, UK. naveedy@tinyonlne.co.uk
authors.forename: N
authors.initials: N
authors.lastname: Younis
authors.forename: H
authors.initials: H
authors.lastname: Soran
authors.forename: S
authors.initials: S
authors.lastname: Farook
mesh_terms: D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000517:prevention & control*; D015444:Exercise; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015431:Weight Loss
chemical_list: D007004:Hypoglycemic Agents