Differential cerebral and neuropsychological consequences in dizygotic twins with prenatal alcohol exposure.
OBJECTIVE
To relate structural and functional findings in one adolescent dizygotic twin pair with prenatal alcohol exposure.


METHODS
Neuropsychological and volumetric magnetic resonance studies were carried out on a 13-year-old preterm dizygotic twin pair with prenatal alcohol exposure.


RESULTS
Neuropsychological and brain structural findings differed between the twins. The child with the more affected phenotype had large-scale cognitive deficits and presented significant atrophy in several brain structures. Both subjects had white matter volume reductions relative to the whole cerebral volume.


CONCLUSIONS
The neuropsychological and neuroimaging data reflect long-term consequences of prenatal alcohol exposure.
Narberhaus
A
A
Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Passeig de la Vall d'Hebron 171, E-08035, Spain.
Segarra
D
D
Giménez
M
M
Caldú
X
X
Junqué
C
C
Bargalló
N
N
Botet
F
F
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000473:pathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D007752:Obstetric Labor, Premature / Q000473:pathology / Q000523:psychology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014429:Twins, Dizygotic / Q000523:psychology*