title: Protein profile of Helicobacter pylori strains by isoelectrofocusing in patients affected by chronic gastritis.
abstract: BACKGROUND
  To understand if relapse, following antimicrobial treatment was due to re-infection or to recrudescence.
  
  
  METHODS
  Fifty patients with dyspepsia were studied prospectively. They were followed up by endoscopy and biopsy of antral mucosa before and after treatment with anti-microbial therapy. Gel isoelectrofocusing was used to characterize protein profile of Hp.
  
  
  RESULTS
  At baseline 40 patients were affected by chronic gastritis associated with Hp. At the end of treatment 75% patients given omeprazole, amoxicillin and clarithromycin were Hp infected: 43% showed the same protein profile and 57% different.
  
  
  CONCLUSIONS
  Our data suggest that the relapse is due to recrudescence or to reinfection.
authors.affiliation: Allergy and Immunology Unit, Policlinico "S. Andrea", II Faculty of Medicine and Surgery, "La Sapienza" University, Rome, Italy.
authors.forename: S Paparo
authors.initials: SP
authors.lastname: Barbaro
authors.forename: G
authors.initials: G
authors.lastname: Petrigni
authors.forename: F
authors.initials: F
authors.lastname: Giovannelli
authors.forename: Fabio
authors.initials: F
authors.lastname: Cerroni
authors.forename: A
authors.initials: A
authors.lastname: Caroselli
authors.forename: R
authors.initials: R
authors.lastname: De Rosa
authors.forename: C
authors.initials: C
authors.lastname: Caroselli
mesh_terms: D000328:Adult; D000368:Aged; D001426:Bacterial Proteins / Q000737:chemistry*; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000378:metabolism*; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000737:chemistry*; D006801:Humans; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D001426:Bacterial Proteins