title: A pathological condition possibly caused by spontaneous trichotecene poisoning in Brahma poultry: first report.
abstract: Trichotecene poisoning in poultry can cause oral lesions, haemorrhages, depletion and necrosis in the lymphopoetic organs and death. Spontaneous poisonings with these toxins are rarely described. This paper describes the spontaneous poisoning of two Brahma chickens with T-2 toxin, diacetoxyscirpenol and deoxynivalenol. Two out of 10 chickens died under signs of depression and loss of appetite. Histopathological analysis revealed vacuolar dystrophy of the liver, necrosis and depletion of lymphocyte in the bursa of Fabricius as well as multiple necroses in the glandular stomach and gut. Even though quantities of 0.70 mg/kg T-2 in the food together with 0.50 mg/kg diacetoxyscirpenol significantly differ from the median lethal dose for chickens reported in literature (4.97 mg/kg), parasitological, virological and histopathological results indicate trichotecenes as the causative agents of this pathological condition.
authors.affiliation: Game Biology, Pathology and Breeding, The Faculty of Veterinary Medicine, University of Zagreb, 10000 Zagreb, Croatia. dean.konjevic@vef.hr
authors.forename: Dean
authors.initials: D
authors.lastname: Konjević
authors.forename: Emil
authors.initials: E
authors.lastname: Srebocan
authors.forename: Andrea
authors.initials: A
authors.lastname: Gudan
authors.forename: Ivana
authors.initials: I
authors.lastname: Lojkić
authors.forename: Kresimir
authors.initials: K
authors.lastname: Severin
authors.forename: Marijana
authors.initials: M
authors.lastname: Sokolović
mesh_terms: D000821:Animal Feed / Q000382:microbiology; D000818:Animals; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D017809:Fatal Outcome; D005670:Fusarium / Q000737:chemistry; D008099:Liver / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D009336:Necrosis; D011041:Poisoning / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000473:pathology*; D013270:Stomach / Q000473:pathology; D013605:T-2 Toxin / Q000506:poisoning*; D014255:Trichothecenes / Q000506:poisoning*
chemical_list: D014255:Trichothecenes; D013605:T-2 Toxin; C007262:deoxynivalenol; C001809:diacetoxyscirpenol