[Pharmacologic therapy in failed thrombolysis: sequential infusion of tirofiban. Pilot study with 47 patients].
Glycoprotein IIb/IIIa inhibitors have been recently proposed as a bridge to rescue transluminal coronary angioplasty in ST elevation myocardial infarction patients in whom thrombolysis fails; but data in its feasibility, safety and efficacy are still limited. In 47 consecutive acute myocardial infarction patients in whom thrombolysis failed to achieve 90 minute reperfusion, tirofiban was given at full regimen. Our results have been compared with those obtained in a control group of 48 consecutive acute myocardial infarction patients admitted two years before, period in which tirofiban and rescue angioplasty were not available in our hospital. Our preliminary data suggest this approach is feasible and safe, with possible clinical benefit in this high-risk subgroup of patients.
Vetrano
Alfredo
A
Dipartimento di Cardiologia, Azienda Ospedaliera San Sebastiano di Caserta, Via Palasciano, 1, Corso Tescione, 81100, Caserta.
Catanzaro
Maurizio
M
Corsini
Fabrizio
F
Carotenuto
Raffaele
R
Sorbo
Raffaele
R
Izzo
Annibale
A
Di Donna
Vincenzo
V
De Lucia
Raffaele
R
Chieffo
Carmelo
C
Corsini
Giancarlo
G
D000368:Aged; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015912:Thrombolytic Therapy; D000077466:Tirofiban; D017211:Treatment Failure; D014443:Tyrosine / Q000008:administration & dosage* / Q000031:analogs & derivatives*
D005343:Fibrinolytic Agents; D014443:Tyrosine; D000077466:Tirofiban