Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck.
OBJECTIVE
In the last years, photodynamic therapy, performed with hematoporphyrin derivatives, gained in importance for the treatment of superficially situated malignomas. The use of hematoporphyrin as photosensitizer is limited especially by the low depth of penetration and its side effects. The aim of the present study was to evaluate the effectiveness of photodynamic therapy with anthracyclin derivates in squamous cell carcinoma cell lines.


METHODS
The photodynamic effects of the anthracyclin derivates adriamycin and epirubicin as well as the effects of the hematoporphyrin derivatives photofrin-II and photosan-3 were examined and compared in 10 squamous cell carcinoma cell lines derived from head and neck tumors.


RESULTS
Beside their cytostatic effect, the applied cytostatics revealed a marked photodynamic effect. A statistically significant difference for photodynamic effects of both cytostatic agents and the hematoporphyrin derivates could not be shown.


CONCLUSIONS
These results revealed that the above mentioned cytostatics could be considered as possible alternative photosensitizer for photodynamic therapy.
Lippert
B M
BM
Department of Otolaryngology, Head and Neck Surgery, Philipps University, Marburg, Germany. lippert@mailer.uni-marbrug.de
Teymoortash
A
A
Külkens
C
C
Folz
B J
BJ
Werner
J A
JA
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000503:physiopathology; D002448:Cell Adhesion / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D017323:Dihematoporphyrin Ether / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology*; D015251:Epirubicin / Q000494:pharmacology; D006415:Hematoporphyrins; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis; D010039:Otorhinolaryngologic Neoplasms / Q000473:pathology* / Q000503:physiopathology; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*
D000970:Antineoplastic Agents; D006415:Hematoporphyrins; D009363:Neoplasm Proteins; D017319:Photosensitizing Agents; C071875:photosan III; D015251:Epirubicin; D004317:Doxorubicin; D017323:Dihematoporphyrin Ether