title: Statistical analysis of wound-healing rates for pressure ulcers.
abstract: To establish a functional model for determining wound-healing rates to use in the evaluation of efficacy of wound therapies, a review was conducted of statistical analysis methods from past wound-healing studies. Because most wounds do not usually close within the period of observation, that is, 12 weeks, evaluating time to 100% closure is not practical. Thus, a new, practical model for statistical analysis was formulated. A Gompertz-like function was applied to wound-healing rates of pressure ulcers, in the context of repeated measures for a nonlinear model. Photographing the wounds weekly, tracing their area with planimetry, and applying this new statistical model allows for the calculation of the expected rate of healing as a function of time. This approach yields a model useful for identifying prognostic factors, evaluating treatments, and improving our understanding of the variables that affect the wound-healing process.
authors.affiliation: Department of Biomathematical Sciences, 1 Gustave Levy Place, Box 1023, Mount Sinai School of Medicine, New York, New York 10029, USA. sylvan.wallenstein@mssm.edu
authors.forename: Sylvan
authors.initials: S
authors.lastname: Wallenstein
authors.forename: Harold
authors.initials: H
authors.lastname: Brem
mesh_terms: D001837:Body Weights and Measures / Q000706:statistics & numerical data; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D006801:Humans; D015233:Models, Statistical; D003668:Pressure Ulcer / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D014945:Wound Healing