[The influence of Aronia Melanocarpa Elliot and acetylcysteine on selected biochemical parameters of experimental animals with chronic lead acetate poisoning].
Lead mostly shows that it accumulates in bones in an insoluble phosphate form. Its toxicity grows with the deficiency of calcium, calciferol, irons and coppers in food. The examination was carried out on 40 female and male Wistar rats weighing 200-250 g. They lived in the animal quarters with a stable temperature and humidity. They were fed with standard fodder (Murigan) and water ad libitum. In the work carried out the effect of anthocyanins of Aronia Melanocarpa Elliot and acetylcysteine on the selected biochemical parameters of experimental animals with chronic lead acetate poisoning were examined. After administration anthocyanins statistically important substantially decreased the concentration of the products of the unsaturated fatty acids oxidation in urine and examined organs. Those anthocyanins also decreased excretion of delta-aminolevulinic acid and 8-hydroxy-2-deoxyguanosine in urine.
Kowalczyk
Edward
E
Zakład Farmakologii i Toksykologii Wojskowej Akademii Medycznej Plac Hallera 1, 90-647 Łódź.
Jankowski
Andrzej
A
Niedworok
Jan
J
Smigielski
Jan
J
Jankowska
Beata
B
D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001842:Bone and Bones / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009942:Organometallic Compounds; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D027824:Rosaceae; D018709:Statistics, Nonparametric; D013997:Time Factors
D000872:Anthocyanins; D000975:Antioxidants; D016166:Free Radical Scavengers; D009942:Organometallic Compounds; D010936:Plant Extracts; C008261:lead acetate