[Obsessive-compulsive symptoms in schizophrenia during treatment with clozapine and conventional antipsychotic drugs].
BACKGROUND
We compare the prevalence of obsessive-compulsive symptoms in schizophrenic patients in treatment with clozapine and those who receive classic antipsychotic drugs.


METHODS
Outpatients with schizophrenia treated with clozapine (n = 56) or classic antipsychotic drugs (n = 54) at the Honorio Delgado-Hideyo Noguchi Specialized Institute in Mental Health (Lima-Peru), were evaluated for the presence of obsessive-compulsive symptoms by means of the Obsessive-Compulsive Disorder Module of Structured Clinical Interview for DSM-IV and Yale-Brown Obsessive-Compulsive Symptoms Checklist.


RESULTS
46.4 % of patients treated with clozapine presented obsessive-compulsive symptoms while this occurred in 20.4 % of those with classic antipsychotic drugs (p = 0.005). In addition, 21.4 % of patients with clozapine and 13 % of those treated with classic antipsychotics presented obsessive-compulsive disorder according to DSM-IV criteria (p = 0.31).


CONCLUSIONS
In schizophrenic patients, treatment with clozapine is associated with a higher rate of obsessive-compulsive symptoms than treatment with classic antipsychotic drugs.
Galvez-Buccollini
J A
JA
Universidad Peruana Cayetano Heredia, Peru. galvezbuccollini@yahoo.com
Fiestas
F
F
Herrera
P
P
Vega-Dienstmaier
J M
JM
Guimas
B
B
Mazzotti
G
G
D000328:Adult; D014150:Antipsychotic Agents / Q000145:classification / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology*; D012559:Schizophrenia / Q000188:drug therapy* / Q000453:epidemiology*
D014150:Antipsychotic Agents; D003024:Clozapine