Cancer preventive potential of Momordica charantia L. against benzo(a)pyrene induced fore-stomach tumourigenesis in murine model system.
Bitter melon ( Momordica charantia Linnaeus) fruit extract was tested against 3,4 benzo(a)pyrene [B(a)P] induced forestomach papillomagenesis in Swiss albino mice. Extract of M. charantia in two concentrations, 2.5 and 5% of standard mice feed was used for the short-term and long-term studies. A significant decrease in tumour burden was observed in short and long-term treatment. Also, total tumour incidence reduced to 83.33% with 2.5% dose and 90.90% with 5% dose in short term treatment, while in long-term treatment tumor incidence decreased to 76.92% with 2.5% dose and 69.23% with 5% dose of M. charantia. The possible mechanism involved in the cancer chemoprevention has also been discussed.
Deep
Gagan
G
Radiation and Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
Dasgupta
Trisha
T
Rao
A R
AR
Kale
R K
RK
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001564:Benzo(a)pyrene; D001835:Body Weight; D002273:Carcinogens; D008297:Male; D051379:Mice; D029777:Momordica charantia / Q000378:metabolism*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010936:Plant Extracts; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D002273:Carcinogens; D010936:Plant Extracts; D001564:Benzo(a)pyrene