New concepts: growth hormone, insulin-like growth factor-I and the kidney.
Both growth hormone (GH) and IGF-1 have major effects on normal kidney growth, structure and function and participate in the pathogenesis of certain kidney diseases. Furthermore when the kidneys fail there are profound changes in the circulating GH-IGF-1 system and the renal and systemic responses to these hormones. In this brief review we address the advances that have been made in our understanding of the relationship between growth hormone GH and IGF-1 and the kidney in health and the systemic and local perturbations that occur in kidney disease and identify key unanswered questions.
Rabkin
Ralph
R
Veterans Affairs Palo Alto Health Care System and Department of Medicine, Stanford University, 3801 Miranda Avenue, Palo Alto, CA 94304, USA. rabkin@stanford.edu
Schaefer
Franz
F
D000818:Animals; D013006:Growth Hormone / Q000502:physiology*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007668:Kidney / Q000502:physiology*; D051437:Renal Insufficiency / Q000503:physiopathology*
D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone