title: LINKER: a web server to generate peptide sequences with extended conformation.
abstract: LINKER was developed as an online server to assist biomedical researchers to design linker sequences for constructing functional fusion proteins. The program automatically generates a set of peptide sequences that are known to adopt extended conformations as determined by X-ray crystallography and NMR. In addition to the desired linker sequence length, the web interface provides a number of optional input parameters so that the users may enhance sequence selection based on the requirements of specific applications. The output of LINKER includes a list of peptide sequences with specified length and sequence characteristics. A graphical subroutine was implemented to highlight the chemical features of every linker sequence by hydrophobicity plots. LINKER can be accessed at http://astro.temple.edu/~feng/Servers/BioinformaticServers.htm.
authors.affiliation: Department of Chemistry, Temple University, 1901 N 13th Street, Philadelphia, PA 19122, USA.
authors.forename: Fan
authors.initials: F
authors.lastname: Xue
authors.forename: Zhong
authors.initials: Z
authors.lastname: Gu
authors.forename: Jin-an
authors.initials: JA
authors.lastname: Feng
mesh_terms: D000595:Amino Acid Sequence; D057927:Hydrophobic and Hydrophilic Interactions; D020407:Internet; D010455:Peptides / Q000737:chemistry* / Q000235:genetics; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000737:chemistry*; D012984:Software; D014584:User-Computer Interface
chemical_list: D010455:Peptides; D011993:Recombinant Fusion Proteins