title: Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide.
abstract: Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 microM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.
authors.affiliation: Institute of Preventive Medicine, National Defense Medical College, National Defense University, Taipei, Taiwan.
authors.forename: Chang-Jer
authors.initials: CJ
authors.lastname: Wu
authors.forename: Jia-Tsrong
authors.initials: JT
authors.lastname: Jan
authors.forename: Chi-Min
authors.initials: CM
authors.lastname: Chen
authors.forename: Hsing-Pang
authors.initials: HP
authors.lastname: Hsieh
authors.forename: Der-Ren
authors.initials: DR
authors.lastname: Hwang
authors.forename: Hwan-Wun
authors.initials: HW
authors.lastname: Liu
authors.forename: Chiu-Yi
authors.initials: CY
authors.lastname: Liu
authors.forename: Hui-Wen
authors.initials: HW
authors.lastname: Huang
authors.forename: Su-Chin
authors.initials: SC
authors.lastname: Chen
authors.forename: Cheng-Fong
authors.initials: CF
authors.lastname: Hong
authors.forename: Ren-Kuo
authors.initials: RK
authors.lastname: Lin
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Chao
authors.forename: John T A
authors.initials: JT
authors.lastname: Hsu
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000998:Antiviral Agents; D002522:Chlorocebus aethiops; D005455:Fluorescent Antibody Technique; D009534:Niclosamide / Q000494:pharmacology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000187:drug effects*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D000998:Antiviral Agents; D009534:Niclosamide