title: Basaloid squamous cell carcinoma of the larynx: a report of four new cases.
abstract: OBJECTIVE
  This study is designed to report the clinical and pathologic features and outcome of cases of basaloid squamous cell carcinoma (BSCC) of the larynx treated in our clinic.
  
  
  METHODS
  A retrospective review of the medical records of these patients.
  
  
  METHODS
  Four cases of BSCC of the larynx were treated in our department. Histopathologic slides were reevaluated to confirm the diagnosis. Immunohistochemical studies were performed, and file records were reviewed. Follow-up was available for all patients and ranged between 11 and 72 (mean 37) months.
  
  
  RESULTS
  All patients were male (mean 57), with supraglottic or transglottic larynx tumors. Two patients presented with stage-II disease and the other 2 with stage-IV disease. Initial diagnosis was invasive squamous cell carcinoma in 3 patients and BSCC in one patient. Two patients who had stage-II disease underwent partial laryngectomy and bilateral neck dissections; total laryngectomy and bilateral neck dissections were performed in stage-IV patients. Three patients received adjuvant postoperative radiotherapy, and 2 of them also received additional chemotherapy. Patients with stage-IV disease were found to have 4 and 27 metastatic lymph nodes on histopathologic examination and died because of distant metastases at 11 and 14 months, respectively. Patients with stage-II disease did not have cervical metastasis on histopathologic examination and were alive and free of disease at 52 and 72 months respectively.
  
  
  CONCLUSIONS
  In contrast with the literature reporting the tendency of more aggressive clinical behavior of the BSCC, we can say that BSCC has a behavior similar to conventional squamous cell carcinoma based on our 4 cases.
authors.affiliation: School of Medicine, Department of Otorhinolaryngology, University of Uludag, Gorukle, Bursa, Turkey.
authors.forename: Levent M
authors.initials: LM
authors.lastname: Erisen
authors.forename: Hakan
authors.initials: H
authors.lastname: Coskun
authors.forename: Sema
authors.initials: S
authors.lastname: Ozuysal
authors.forename: Oguz
authors.initials: O
authors.lastname: Basut
authors.forename: Selcuk
authors.initials: S
authors.lastname: Onart
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Hizalan
authors.forename: Ilker
authors.initials: I
authors.lastname: Tezel
mesh_terms: D002281:Carcinoma, Basosquamous / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome