Moxifloxacin and biofilm production by coagulase-negative staphylococci.
The in vitro activity of moxifloxacin against 41 strains of coagulase-negative staphylococci was determined. A relationship between the activity of moxifloxacin and biofilm formation was detected. Biofilm-producing strains were more resistant to moxifloxacin than biofilm-negative strains. Our global results obtained with six strains of Staphylococcus epidermidis showed that subinhibitory concentrations of moxifloxacin did not significantly modify biofilm formation. On the other hand, moxifloxacin concentrations of 2, 10, 50 and 100 x MIC produced a log decrease in viable count (included in a biofilm) of 0.20, 0.37, 1.10 and 1.69, respectively.
Pérez-Giraldo
C
C
Department of Microbiology, Faculty of Medicine, Extremadura University, Badajoz, Spain.
Gonzalez-Velasco
C
C
Sánchez-Silos
R M
RM
Hurtado
C
C
Blanco
M T
MT
Gómez-García
A C
AC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D003030:Coagulase / Q000378:metabolism; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D011804:Quinolines / Q000494:pharmacology*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology
D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D003030:Coagulase; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin