[Influence of recent trials on essential arterial hypertension management].
Following recent trials, U.S (JNC7), European (ESH/ESC) and world (WHO) guidelines concerning the management of arterial essential hypertension have recently been updated. They indicate that hypertension treatment may succeed in preventing complications such as stroke or myocardial infarction. The therapeutic target is less than 140/90 mmHg (130/80 mmHg for diabetics). To reach this objective, a combination using a diuretic is required in almost all cases. Trials comparing the efficiency of "old drugs" such as diuretics or beta-blockers with "new drugs" such as ACEI or ARAII, or CCB observed minor differences in terms of cardiovascular outcomes. However, ACEI and ARAII appeared to be of particular efficiency in preventing heart and kidney failures.
Rossignol
Patrick
P
Unité d'hypertension artérielle, Hôpital européen Georges Pompidou, 75908 Paris Cedex 15. patrick.rossignol@hop.egp.ap-hop-paris.fr
Le Coz
Sylvie
S
Plouin
Pierre-François
PF
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use; D006331:Heart Diseases / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007674:Kidney Diseases / Q000209:etiology / Q000517:prevention & control; D017410:Practice Guidelines as Topic; D014944:World Health Organization
D000959:Antihypertensive Agents; D004232:Diuretics