Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and apparently healthy ones.
Recent studies have shown that C-reactive proteins have a pathogenetic role in atherothrombosis and concentrations of these substances could be used as a marker for future vascular events. The objective of this study was to determine gender differences in highly sensitive C-reactive protein (hs-CRP) in individuals with atherothrombotic risk factors and apparently healthy ones. We have presently matched 469 females and 469 males having the same age and body mass index (BMI). Of these, 210 men and 210 women had no atherothrombotic risk factors. In this group the hs-CRP concentrations were 1.6+/-3.4 mg l(-1) in women and 1.0+/-2.7 mg l(-1) in men (p<0.0005). These values were 2.1+/-3.4 mg l(-1) and 1.5+/-2.8 mg l(-1), respectively, in the entire cohort (p<0.0005), which included also individuals with atherothrombotic risk factors. We conclude that significant gender differences exist in hs-CRP concentrations despite perfect matching for age and BMI. These differences should be reflected in guidelines that suggest hs-CRP cut-off points for the stratification of vascular risk.
Rogowski
Ori
O
Department of Internal Medicine D Tel-Aviv Sourasky Medical Center 6 Weizman Street Tel Aviv 64239, Israel.
Zeltser
David
D
Shapira
Itzhak
I
Burke
Michael
M
Zakut
Vera
V
Mardi
Tamar
T
Ben-Assayag
Einor
E
Serov
Jack
J
Rozenblat
Meirav
M
Berliner
Shlomo
S
D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology*; D015415:Biomarkers; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000096:biosynthesis*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity; D012307:Risk Factors; D012737:Sex Factors
D015415:Biomarkers; D002097:C-Reactive Protein