title: Fatal hydrogen sulfide poisoning at a dye works.
abstract: An adult Japanese man (A) entered a pit to remove sludge in a drainage pipe at a dye works in Japan. When he took off a joint of the pipe, the sludge in the pipe flowed into the pit. As he suddenly lost consciousness, three colleagues (B, C, D) entered the pit to rescue him. All of these (A, B, C and D) lost consciousness in the pit, and died soon after the accident. Since hydrogen sulfide gas was detected in the sludge of the pit, gas poisoning was suspected. Toxicological analyses of sulfide and thiosulfate, a metabolite of sulfide, in blood and urine of the victims were made, using the extractive alkylation technique combined with gas chromatography/mass spectrometry. Sulfide and thiosulfate were detected in whole blood of the four workers at levels of 0.32-9.36 mg/l and 0.11-0.23 mmol/l, respectively. These concentrations were at least 6-187 times higher in sulfide and 37-77 times higher in thiosulfate than those in healthy persons, and were similar to values found in fatal cases of hydrogen sulfide poisoning. Thiosulfate was not detected in the urine of four workers, which indicated acute death. Based on these results, all four patients were victims of hydrogen sulfide poisoning, who died soon after the exposure.
authors.affiliation: Forensic Science Laboratory, Fukuoka Prefectural Police Headquarters, 7-7, Higashikoen, Hakata-ku, Fukuoka 812-8576, Japan.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kage
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Noriaki
authors.initials: N
authors.lastname: Ikeda
authors.forename: Akira
authors.initials: A
authors.lastname: Tsujita
authors.forename: Keiko
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000506:poisoning*; D002617:Chemical Industry; D004396:Coloring Agents; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood / Q000506:poisoning* / Q000652:urine; D007220:Industrial Waste / Q000009:adverse effects*; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D013885:Thiosulfates / Q000097:blood / Q000652:urine
chemical_list: D000393:Air Pollutants; D004396:Coloring Agents; D007220:Industrial Waste; D013885:Thiosulfates; D006862:Hydrogen Sulfide