title: Metallothionein in male reproductive organs of adrenalectomized and hydrocortisone-treated Wistar rats.
abstract: Adrenalectomy resulted in an increase in metallothionein (MT) levels in testes, caput and cauda epididymis and prostate of rats but not in seminal vesicles where its levels decreased significantly. Inspite of administration of hydrocortisone, MT in testes, prostate (1.2 mg), caput (0.3 mg days 2, 8; 0.6 mg and 1.2 mg) and seminal vesicles (0.3 mg day 2, 4; 0.6 mg and 1.2 mg) remained increased. Thus adrenal insufficiency/hydrocortisone has no direct influence on MT levels. However, the increased levels of MT can be related to its ability to protect the cells from free radical damage caused by atrophy of reproductive tissues in adrenalectomised rats. Exogenously administered hydrocortisone to ADX rats resulted in return to ADX state as hydrocortisone metabolizes (half-life < 12 hr) and hence MT levels remained increased. The observations could provide a clue for the physiological functioning of the male reproductive tissue in a state of adrenal deprivation and hormonal supplementation.
authors.affiliation: Cell Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302 004, India.
authors.forename: Neena
authors.initials: N
authors.lastname: Nair
authors.forename: R S
authors.initials: RS
authors.lastname: Bedwal
mesh_terms: D000311:Adrenal Glands / Q000502:physiology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004822:Epididymis / Q000378:metabolism*; D005609:Free Radicals; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis*; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000378:metabolism; D013737:Testis / Q000378:metabolism*
chemical_list: D000893:Anti-Inflammatory Agents; D005609:Free Radicals; D008668:Metallothionein; D006854:Hydrocortisone