title: Comparative study of genetic variation at 15 STR loci in three isolated populations of the Bosnian mountain area.
abstract: Fifteen autosomal STR loci (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX, and FGA) were studied in three geographically close but isolated populations from the Bosnian mountain area. The three villages are Bobovica, Dejcici, and Lukomir. DNA was obtained from 83 individuals, and the allele frequencies and genetic diversity among the three sample groups were compared. In addition, seven of the STR loci (CSF1PO, D13S317, D3S1358, D5S818, D7S820, FGA, TH01) were used in a comparative population analysis of the Bjelasnica-Treskavica region and the Adriatic islands of Brac, Hvar, and Korcula. Although the sample sizes are relatively small, the observed variation within any of the small isolated populations is high and comparable to less isolated groups. In addition, even though the populations are geographically isolated, the STR data are similar among the populations. The most significant frequency differences were observed at the TH01 locus. Although the specific allele distributions in any untyped population cannot be determined a priori, we find support for a high degree of diversity for the STR loci in most populations. In addition, the multiple locus profile is highly informative not only for various population studies but also for forensic studies, even when specific population data are not available.
authors.affiliation: Institute for Genetic Engineering and Biotechnology, Kemalbegova 10. 71000 Sarajevo, Bosnia and Herzegovina.
authors.forename: D
authors.initials: D
authors.lastname: Marjanovic
authors.forename: L
authors.initials: L
authors.lastname: Kapur
authors.forename: K
authors.initials: K
authors.lastname: Drobnic
authors.forename: B
authors.initials: B
authors.lastname: Budowle
authors.forename: N
authors.initials: N
authors.lastname: Pojskic
authors.forename: R
authors.initials: R
authors.lastname: Hadziselimovic
mesh_terms: D017522:Bosnia and Herzegovina / Q000453:epidemiology; D016172:DNA Fingerprinting; D005191:Family Characteristics; D018732:Forensic Anthropology; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D005828:Genetics, Population; D005843:Geography; D006801:Humans; D009061:Mouth Mucosa; D016133:Polymerase Chain Reaction; D040641:Quantitative Trait Loci / Q000235:genetics; D012424:Rural Population / Q000706:statistics & numerical data*; D012934:Social Isolation; D020080:Tandem Repeat Sequences / Q000235:genetics*