title: Age-related changes in ocular and corneal aberrations.
abstract: OBJECTIVE
  To compare the ocular and corneal higher-order aberrations (HA) in eyes of different ages.
  
  
  METHODS
  Observational cross-sectional study.
  
  
  METHODS
  Sixty-six eyes of 66 normal subjects (age range 4-69 years; average 37.4 +/- 15.4 years) were examined. Wavefront aberrations of the whole eye (ocular) and cornea were measured for the central 4 mm using a Hartmann-Shack aberrometer.
  
  
  RESULTS
  Ocular Coma-like aberration (r = 0.270, P =.029), Spherical-like aberration (r = 0.531, P =.001), and total HA(r = 0.431, P =.001) were significantly correlated with age, whereas the corneal aberrations were not significantly correlated. The ocular total HA aberrations increased significantly after age 50 years.
  
  
  CONCLUSIONS
  After 50 years of age, ocular aberrations increased abruptly due to the increase of lenticular HA. Customized ablation should be carefully considered, especially in eyes of presbyopic age.
authors.affiliation: Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka, Suita-shi Osaka 565-0871, Japan. fujikado@ophthal.med.osaka-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujikado
authors.forename: Teruhito
authors.initials: T
authors.lastname: Kuroda
authors.forename: Sayuri
authors.initials: S
authors.lastname: Ninomiya
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Maeda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tano
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oshika
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hirohara
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Mihashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D003316:Corneal Diseases / Q000503:physiopathology*; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D006801:Humans; D008875:Middle Aged; D012030:Refractive Errors / Q000503:physiopathology*; D014786:Vision Disorders / Q000503:physiopathology*