Apoptotic changes in the myocardium in the course of experimentally-induced pleurisy.
The secreted proinflammatory interleukins IL-1, IL-6 and TNF in the course of experimentally-induced pleurisy can be the cause of pathological changes in the ultrastructure of cardiac muscle and of apoptosis. The pleurisy was induced in rats by means of carrageenin. The scraps of cardiac muscle obtained during the inflammatory reaction in the pleura were analysed by means of an electron microscope. The scraps were also stained with the TUNEL method in order to find the apoptotic foci. It was proved by the experiment that the inflammatory process affected mitochondria in the cardiomyocytes, enhanced collagen fibre synthesis and contributed to the formation of apoptotic foci in the cardiac muscle.
Całkosiński
Ireneusz
I
Department of Physiology, Medical University, Wrocław, Poland. m.calkosinska@xl.wp.pl
Cegielski
Marek
M
Dziegiel
Piotr
P
Skalik
Robert
R
Majda
Jacek
J
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D006352:Heart Ventricles / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D020287:In Situ Nick-End Labeling; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects / Q000648:ultrastructure; D009205:Myocarditis / Q000209:etiology* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D010998:Pleurisy / Q000139:chemically induced / Q000150:complications / Q000473:pathology; D051381:Rats; D011915:Rats, Inbred BUF
D003094:Collagen