Highly purified lipoteichoic acid from Staphylococcus aureus induces procoagulant activity and tissue factor expression in human monocytes but is a weak inducer in whole blood: comparison with peptidoglycan.
Lipoteichoic acid from Staphylococcus aureus was a potent inducer of procoagulant activity in isolated mononuclear cells but not in whole blood. In contrast, staphylococcal peptidoglycan showed equal levels of potency in isolated mononuclear cells and whole blood, suggesting that peptidoglycan is an important inducer of procoagulant activity in severe sepsis involving gram-positive bacteria.
Mattsson
Eva
E
Department of Clinical Microbiology, University Hospital Utrecht, Heidelberglaan 100, P.O. Box 85.500, 3508 GA Utrecht, Holland. eva.mattsson@wanadoo.nl
Hartung
Thomas
T
Morath
Siegfried
S
Egesten
Arne
A
D001769:Blood / Q000187:drug effects; D001777:Blood Coagulation / Q000187:drug effects*; D003029:Coagulants / Q000494:pharmacology*; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects*; D010457:Peptidoglycan / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000378:metabolism; D013682:Teichoic Acids / Q000494:pharmacology*; D013925:Thromboplastin / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics
D003029:Coagulants; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D013682:Teichoic Acids; C009900:lipoteichoic acid; D013925:Thromboplastin