Sites of neocortical reorganization critical for remote spatial memory.
The hippocampus is crucial for spatial memory formation, yet it does not store long-lasting memories. By combining functional brain imaging and region-specific neuronal inactivation in mice, we identified prefrontal and anterior cingulate cortices as critical for storage and retrieval of remote spatial memories [correction]. Imaging of activity-dependent genes also revealed an involvement of parietal and retrosplenial cortices during consolidation of remote memory. Long-term memory storage within some of these neocortical regions was accompanied by structural changes including synaptogenesis and laminar reorganization, concomitant with a functional disengagement of the hippocampus and posterior cingulate cortex [correction]. Thus, consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently.
Maviel
Thibault
T
Laboratoire de Neurosciences Cognitives, CNRS UMR 5106, Université de Bordeaux 1, Avenue des Facultés, 33405 Talence, France.
Durkin
Thomas P
TP
Menzaghi
Frédérique
F
Bontempi
Bruno
B
D000818:Animals; D001931:Brain Mapping; D019922:GAP-43 Protein / Q000378:metabolism; D005786:Gene Expression Regulation; D017781:Genes, Immediate-Early; D006179:Gyrus Cinguli / Q000502:physiology*; D017874:Immediate-Early Proteins / Q000378:metabolism; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D011939:Mental Recall; D051379:Mice; D008810:Mice, Inbred C57BL; D019579:Neocortex / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D013997:Time Factors
D019922:GAP-43 Protein; D017874:Immediate-Early Proteins; D008012:Lidocaine