title: Diverse and potent activities of HGF/SF in skin wound repair.
abstract: Genetic studies in the mouse have highlighted essential roles for several growth factors in skin repair and have offered a rationale for their use in therapy. The present study shows that the plasminogen-related growth factor HGF/SF (hepatocyte growth factor/scatter factor) promotes wound repair in homozygous diabetic db/db mice by recruiting neutrophils, monocytes, and mast cells to the wound; by promoting the migration of endothelial cells to the injured area; and by enhancing keratinocyte migration and proliferation. As a result, granulation tissue formation, wound angiogenesis, and re-epithelialization are all increased. The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds.
authors.affiliation: School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK.
authors.forename: Damon
authors.initials: D
authors.lastname: Bevan
authors.forename: Ermanno
authors.initials: E
authors.lastname: Gherardi
authors.forename: Tai-Ping
authors.initials: TP
authors.lastname: Fan
authors.forename: Dylan
authors.initials: D
authors.lastname: Edwards
authors.forename: Richard
authors.initials: R
authors.lastname: Warn
mesh_terms: D000818:Animals; D004847:Epithelial Cells / Q000187:drug effects; D006097:Granulation Tissue / Q000187:drug effects; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D015603:Keratinocytes / Q000187:drug effects; D008407:Mast Cells / Q000502:physiology; D051379:Mice; D009000:Monocytes / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D020556:Neutrophil Infiltration / Q000187:drug effects; D012867:Skin / Q000098:blood supply / Q000293:injuries*; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D017228:Hepatocyte Growth Factor