A combinatorial approach to the synthesis of cystine based organogelators.
A solid-phase approach was used to prepare 20 cystine amide derivatives with disulfide bond formation resulting from an intra-site reaction between neighbouring cysteine residues. Library members were screened as potential organogelators in a range of solvent mixtures and resulted in the identification of a potent gelator able to rigidify water/DMSO mixtures at concentrations as low as 1.3 mM.
Matteucci
Mizio
M
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton SO17 1BJ, UK.
Bhalay
Gurdip
G
Bradley
Mark
M
D000577:Amides / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003545:Cysteine / Q000737:chemistry; D003553:Cystine / Q000031:analogs & derivatives* / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D015394:Molecular Structure
D000577:Amides; D005782:Gels; D003553:Cystine; D003545:Cysteine