Coregulator-related diseases.
Coregulators are a group of proteins, which modulate the nuclear receptor transactivation function. In this study, a new "coregulator disease" concept was proposed from observations of a case of androgen insensitivity syndrome (AIS) and cases involving Rubinstein-Taybi syndrome and X-linked dementia and hypothyroidism syndrome. In addition, coregulators are thought to be closely associated with the pathogenesis of several diseases such as hormone-dependent cancers and leukemia. Based on these observations, the clinical disorders associated with some coregulator abnormalities were reviewed.
Yanase
Toshihiko
T
Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582.
Adachi
Masahiro
M
Goto
Kiminobu
K
Takayanagi
Ryoichi
R
Nawata
Hajime
H
D013734:Androgen-Insensitivity Syndrome / Q000235:genetics* / Q000503:physiopathology; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism; D012415:Rubinstein-Taybi Syndrome / Q000235:genetics* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D018382:Thyroid Hormone Resistance Syndrome / Q000235:genetics* / Q000503:physiopathology; D015534:Trans-Activators; D015533:Transcriptional Activation / Q000502:physiology*
D004268:DNA-Binding Proteins; D011944:Receptors, Androgen; D015534:Trans-Activators