Doxycycline and intracranial hypertension.
The authors report seven patients from six neuro-ophthalmology referral centers who developed pseudo-tumor cerebri during treatment with doxycycline. All four female patients and one of three male patients were obese. Vision was minimally affected in most patients, but two had substantial visual acuity or visual field loss at presentation. Discontinuation of doxycycline, with or without additional intracranial pressure-lowering agents, yielded improvement, but permanent visual acuity or visual field loss occurred in five patients.
Friedman
D I
DI
Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, NY 14642, USA. Deborah_Friedman@urmc.rochester.edu
Gordon
L K
LK
Egan
R A
RA
Jacobson
D M
DM
Pomeranz
H
H
Harrison
A R
AR
Goldhammer
Y
Y
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004318:Doxycycline / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000139:chemically induced*; D008297:Male; D009765:Obesity; D012307:Risk Factors
D000900:Anti-Bacterial Agents; D004318:Doxycycline