title: Practical and quality-control aspects of multi-element analysis with quadrupole ICP-MS with special attention to urine and whole blood.
abstract: Two screening methods were developed for rapid analysis of a great number of urine and blood samples within the framework of an exposure check of the population after a firework explosion. A total of 56 elements was measured including major elements. Sample preparation consisted of simple dilution. Extensive quality controls were applied including element addition and the use of certified reference materials. Relevant results at levels similar to those found in the literature were obtained for Co, Ni, Cu, Zn, Sr, Cd, Sn, Sb, Ba, Tl, and Pb in urine and for the same elements except Ni, Sn, Sb, and Ba in blood. However, quadrupole ICP-MS has limitations, mainly related to spectral interferences, for the analysis of urine and blood, and these cause higher detection limits. The general aspects discussed in the paper give it wider applicability than just for analysis of blood and urine-it can for example be used in environmental analysis.
authors.affiliation: RIVM, 3720 BA, Bilthoven, The Netherlands. jan.de.boer@rivm.nl
authors.forename: Jan L M
authors.initials: JL
authors.lastname: De Boer
authors.forename: Rob
authors.initials: R
authors.lastname: Ritsema
authors.forename: Sjoerd
authors.initials: S
authors.lastname: Piso
authors.forename: Hans
authors.initials: H
authors.lastname: Van Staden
authors.forename: Wilbert
authors.initials: W
authors.lastname: Van Den Beld
mesh_terms: D002138:Calibration; D004781:Environmental Exposure / Q000032:analysis; D006801:Humans; D007554:Isotopes; D013058:Mass Spectrometry / Q000379:methods*; D011786:Quality Control; D012015:Reference Standards; D012680:Sensitivity and Specificity; D014131:Trace Elements / Q000097:blood* / Q000652:urine*
chemical_list: D007554:Isotopes; D014131:Trace Elements