[Expression of focal adhesion kinase in laryngeal carcinoma].
OBJECTIVE
To evaluate the pattern of FAK expression in laryngeal squamosa cell carcinoma and non-carcinoma tissue.


METHODS
Expression of FAK was examined in 100 specimens with laryngeal squamosa cell carcinoma and 60 specimens with non-carcinoma, in which 8 cases were in stage I, 23 cases in stage II, 38 cases in stage III and 31 cases in stage IV.


RESULTS
The staining of FAK was stronger in laryngeal squamous cell carcinomas than in the cell of non-carcinoma areas. The cancers with lymphnode metastasis had more FAK protein than the cancers with out lymph node metastasis. Survival rate at 3 and 5 years was 76.9%(50/65) and 61.5%(40/65) respectively for positive staining group of FAK, compared to 97.1%(34/35) and 88.6% (31/35) respectively for negative staining group.


CONCLUSIONS
The results in the report show that the level of FAK expression might be a valuable marker for carcinogeneandsis and the progression of carcinoma.
Yu
Feng
F
Department of Otolaryngology-Head and Neck Surgery, Guangzhou Hospital of Otolaryngology-Head and Neck Surgery, Guangzhou, 510620, China.
Dong
Yuli
Y
Jiao
Yuelong
Y
Zhang
Haoliang
H
Li
Xiaobing
X
Liang
Zijian
Z
Xie
Jia
J
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000473:pathology; D005260:Female; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011505:Protein-Tyrosine Kinases / Q000032:analysis*
D014408:Biomarkers, Tumor; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human