title: Ischemic stroke and fibrinogen in the elderly.
abstract: Senescence is accompanied by an important increase in prevalence and incidence of ischemic stroke. The plasma level of fibrinogen tends to increase with age in the elderly similarly to the prevalence of stroke. The aim of our study was to evaluate the age-related increase in fibrinogen plasma level in the elderly and to assess the presence of eventual differences between normal subjects and patients with previous ischemic stroke associated with precerebral atherosclerosis. Eighty inpatients (41 males and 39 females), consecutively admitted to our Geriatric Unit, were included to this study. The patient group was formed 32 subjects (20 males and 12 females) aged 50-79 years, suffering from cerebrovascular disease with one or several previous ischemic stroke episodes, having occurred at least 1 year earlier. The control group consisted of 48 normal subjects (21 males and 27 females) aged 50-79 years. Both control and patient groups were subdivided into three subgroups, according to their age: Group 1 (50-59 years), Group 2 (60-69 years)and Group 3 (70-79 years). The statistical comparison was carried out by means of the Mann-Whithney nonparametric test. In normal controls, a mild age effect is evident because only Group 3 shows fibrinogen levels significantly higher than those of Group 1. On the contrary, in patients with ischemic stroke, an age effect is already evident between Group 2 and Group 1; of course, also the comparison between patient Group 3 and Group I shows a statistically significant difference. Moreover, the levels of fibrinogen were significantly increased in patient Group 2 and 3 when compared to those of their respective age-matched controls. Our data are in agreement with those already available in the literature and demonstrate that fibrinogen in normal aging changes with age and shows a 19 %increase between age Group 1 and Group 3. Patients with ischemic stroke show an earlier and more evident age-related increase in fibrinogen than normal controls. Even if it is not possible to know, if the increase in fibrinogen is a consequence or not of the ischemic stroke, we can affirm that certainly the increased levels of fibrinogen should be considered as an important risk factor in the elderly for cerebrovascular disease and deserve treatment.
authors.affiliation: Geriatric Unit, Oasi Institute for Research on Mental Retardation and Brain Aging (I.R.C.C.S.), I-94018 Troina (Enna) Italy. rsspada@oasi.en.it
authors.forename: R S
authors.initials: RS
authors.lastname: Spada
authors.forename: G
authors.initials: G
authors.lastname: Toscano
authors.forename: S
authors.initials: S
authors.lastname: Chiarenza
authors.forename: S
authors.initials: S
authors.lastname: Di Mauro
authors.forename: F I I
authors.initials: FI
authors.lastname: Cosentino
authors.forename: I
authors.initials: I
authors.lastname: Iero
authors.forename: B
authors.initials: B
authors.lastname: Lanuzza
authors.forename: M
authors.initials: M
authors.lastname: Tripodi
authors.forename: R
authors.initials: R
authors.lastname: Ferri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D002545:Brain Ischemia / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D014057:Tomography, X-Ray Computed
chemical_list: D005340:Fibrinogen; D002097:C-Reactive Protein