title: 5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease.
abstract: OBJECTIVE
  To investigate the association between 5-HT(2A) receptor polymorphism and neuropsychiatric (NP) symptoms in Chinese elderly with Alzheimer's disease (AD).
  
  
  METHODS
  This case-control study evaluated Chinese subjects with AD first presented to an university affiliated psychogeriatric clinic. Eighty-seven subjects with NINCDS-ADRDA diagnosis for probable and possible AD were recruited consecutively from the psychogeriatric clinics of the Prince of Wales Hospital in Hong Kong. 5-HT(2A) receptor polymorphisms were examined by polymerase chain reaction (PCR), enzyme digestion and gel electrophoresis. NP symptoms were assessed by the Chinese version of the Neuropsychiatric Inventory (NPI).
  
  
  RESULTS
  The genotype frequencies were significantly different in subjects with regards to the presentation of delusions, aggression, aberrant motor behavior and apathy (Pearson Chi Squares, p < 0.05). If only homozygote states were included, there were significantly fewer subjects of CC genotype with delusion (Pearson chi square, p < 0.05).
  
  
  CONCLUSIONS
  Specific NP symptoms in AD were significantly associated with 5-HT(2A) receptor polymorphisms. Possible ethnic differences in the behavioral expression of 5-HT(2A) receptor polymorphisms are worthy of further exploration.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, PRC. cwlam@cuhk.edu.hk
authors.forename: Linda Chiu Wa
authors.initials: LC
authors.lastname: Lam
authors.forename: Nelson Leung Sang
authors.initials: NL
authors.lastname: Tang
authors.forename: Suk Ling
authors.initials: SL
authors.lastname: Ma
authors.forename: Weimin
authors.initials: W
authors.lastname: Zhang
authors.forename: Helen Fung Kum
authors.initials: HF
authors.lastname: Chiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology*; D016022:Case-Control Studies; D003702:Delusions / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012920:Social Behavior Disorders / Q000235:genetics
chemical_list: D044402:Receptor, Serotonin, 5-HT2A