RB from a bud's eye view.
RB and related proteins block transcriptional activation of genes critical to initiation of the cell cycle and suppress unwanted cell division. The circuitry controlling this response is generally conserved from humans to yeast, but no negative regulator like RB has been found in yeast. In this issue of Cell, two studies reveal that Whi5 appears to play the role of RB in preventing precocious cell cycle entry in budding yeast.
Schaefer
Jonathan B
JB
Fred Hutchinson Cancer Research Center, Basic Sciences Division, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.
Breeden
Linda L
LL
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division; D019143:Evolution, Molecular; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D005809:Genes, Regulator; D006801:Humans; D012097:Repressor Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
D018797:Cell Cycle Proteins; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors