title: A randomized comparison of oral chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in Laos.
abstract: Between June and October 2000 we conducted the first randomized trial in Laos comparing chloroquine (CQ) with sulfadoxine-pyrimethamine (SP) in the treatment of uncomplicated Plasmodium falciparum malaria (n = 29, 42-d follow-up, age > 5 years). The proportion of patients with treatment failure was high (CQ = 78%, RIII 46%; SP = 36%, RIII 15%). The treatment policy for uncomplicated P. falciparum malaria in Laos needs to be reviewed urgently.
authors.affiliation: Department of Medicine, Faculty of Medical Science, National University of Laos, Laos.
authors.forename: Mayfong
authors.initials: M
authors.lastname: Mayxay
authors.forename: Rattanaxay
authors.initials: R
authors.lastname: Phetsouvanh
authors.forename: Samlane
authors.initials: S
authors.lastname: Phompida
authors.forename: Paul N
authors.initials: PN
authors.lastname: Newton
authors.forename: Maniphone
authors.initials: M
authors.lastname: Khanthavong
authors.forename: Bouakham
authors.initials: B
authors.lastname: Vannachone
authors.forename: Alan
authors.initials: A
authors.lastname: Brockmans
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000962:Antimalarials / Q000627:therapeutic use*; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D011739:Pyrimethamine / Q000627:therapeutic use*; D016037:Single-Blind Method; D013413:Sulfadoxine / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D002738:Chloroquine; D011739:Pyrimethamine