title: [Obstructive sleep apnea syndrome and hypothyroidism (a report of three cases)].
abstract: OBJECTIVE
  To explore the relationship between obstructive sleep apnea syndrome (OSAS) and hypothyroidism, and to discuss the management experience.
  
  
  METHODS
  Three cases of severity OSAS with hypothyroidism were reported and relevant literatures were reviewed. One patient underwent continuous positive airway pressure (CPAP), one patient was performed uvulopalatopharyngoplasty(UPPP), and one case is in follow-up now.
  
  
  RESULTS
  Thyroxine replacement therapy was effective in improving symptoms and nocturnal sleep apnea.
  
  
  CONCLUSIONS
  Hypothyroidism probably plays a significant role in the pathogenesis of obstructive sleep apnea, the satisfactory results would be obtained by thyroxine replacement therapy, CPAP or surgical treatment can be used as adjuvant therapy in patients with this disease.
authors.affiliation: Department of Otolaryngology, Affiliated Hospital of Medical College Qingdao University, Qingdao, 266003, China.
authors.forename: Guangfeng
authors.initials: G
authors.lastname: Jiang
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
mesh_terms: D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000628:therapy; D013974:Thyroxine / Q000627:therapeutic use; D014609:Uvula / Q000601:surgery
chemical_list: D013974:Thyroxine