title: Chemical constituents and bioactivity of Piper sarmentosum.
abstract: Eight amides, pellitorine (1), guineensine (2), brachystamide B (3), sarmentine (4), brachyamide B (5), 1-piperettyl pyrrolidine (6), 3',4',5'-trimethoxycinnamoyl pyrrolidine (7) and sarmentosine (8), two lignans, (+)-asarinin (9) and sesamin (10), and four other compounds, 1-(3,4-methylenedioxyphenyl)-1E-tetradecene (11), methyl piperate (12) and a mixture of beta-sitosterol (13) and stigmasterol (14), were isolated from the fruits of Piper sarmentosum (Piperaceae). This is the first reported isolation of compounds 2, 3, 5, 6, 7, 9, 10 and 12 from this plant species. Their structures were established from spectral data. These compounds were evaluated in antituberculosis and antiplasmodial tests. The results showed that compounds 4 and 6 exhibited both activities while compounds 1, 2, 5, 8 and 11 showed only antituberculosis activity. This is the first report of the antituberculosis and antiplasmodial activities for these compounds.
authors.affiliation: Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand. thitima@ram1.ru.ac.th
authors.forename: Thitima
authors.initials: T
authors.lastname: Rukachaisirikul
authors.forename: Puttan
authors.initials: P
authors.lastname: Siriwattanakit
authors.forename: Kanchanawadee
authors.initials: K
authors.lastname: Sukcharoenphol
authors.forename: Chanika
authors.initials: C
authors.lastname: Wongvein
authors.forename: Phongpan
authors.initials: P
authors.lastname: Ruttanaweang
authors.forename: Phaopong
authors.initials: P
authors.lastname: Wongwattanavuch
authors.forename: Apichart
authors.initials: A
authors.lastname: Suksamrarn
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005638:Fruit; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D000995:Antitubercular Agents; D010936:Plant Extracts