The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure.
The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L-tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L-tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/24h) and decreased renal function L-tryptophan load does not influence the glomerular filtration rate.
Martinsons
Agris
A
Latvia Medical Academy, Kuldigas 23-4, Riga, Latvia. agrism@latnet.lv
Rudzite
Vera
V
Cernevskis
Harijis
H
Mihailova
Inese
I
Smeltere
Zane
Z
D000284:Administration, Oral; D016022:Case-Control Studies; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D005921:Glomerulonephritis / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000503:physiopathology; D012709:Serum Albumin / Q000378:metabolism; D014364:Tryptophan / Q000008:administration & dosage / Q000097:blood
D012709:Serum Albumin; D014364:Tryptophan; D003404:Creatinine