title: Genotoxicity of cis-PtII complex of 3-aminoflavone in comparison with cis-DDP in A549 cells evaluated by comet assay.
abstract: Cis-diamminedichloroplatinum(II) (cis-DDP) is one of the most successful antineoplastic drugs. However, besides effectiveness it gives many side effects. Therefore, current studies are concentrated on searching for new analogs equally effective in chemotherapy but less toxic. Comparison of genotoxic properties of cis-Pt(II) complex of 3-aminoflavone and cis-DDP in a comet assay with and without H2O2 application was performed in A549 cell line. The higher tail moment values were noticed for the former compound contrary to the latter one in both variants. It suggests mainly DNA breaks (besides cross-links) appearance after cis-Pt(II) complex of 3-aminoflavone application and might indicate DNA degradation in comparison with cis-DDP.
authors.affiliation: Department of Cytogenetics and Plant Molecular Biology, University of Lodz, Poland. kosbea@biol.uni.lodz.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Kosmider
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Zyner
authors.forename: Regina
authors.initials: R
authors.lastname: Osiecka
authors.forename: Justyn
authors.initials: J
authors.lastname: Ochocki
mesh_terms: D045744:Cell Line, Tumor; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000633:toxicity*; D020552:Comet Assay / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000633:toxicity*; D006801:Humans
chemical_list: C488624:3-aminoflavone; D005419:Flavonoids; D002945:Cisplatin