title: Effect of white matter changes on cognitive impairment in patients with lacunar infarcts.
abstract: OBJECTIVE
  Cerebral white matter changes (WMC) and lacunar infarct are both believed to be consequence of small vessel disease. Whether the extent of WMC affect the type and degree of cognitive impairment in patients with lacunar infarct is not clear. The study was undertaken to determine if WMC influences cognition in patients with lacunar infarcts.
  
  
  METHODS
  We recruited consecutive patients who were admitted to the acute stroke unit because of acute lacunar infarcts, mainly documented by diffusion-weighted magnetic resonance imaging. WMC were measured qualitatively and quantitatively. Patients were divided into quartiles according to the distribution of the volume of WMC. Cognition was assessed 12 weeks after stroke by psychometric tests (Chinese version of Mini-Mental State Examination [MMSE], Alzheimer's Disease Assessment Scale-cognition [ADAS-cog], Mattis Dementia Rating Scale-Initiation/ Perseveration subscale [MDRS I/P]) and was compared between patients with varying severity of WMC. Multivariate linear regression analysis was performed to find variables that influenced performance in the psychometric tests.
  
  
  RESULTS
  Among the 94 included patients with acute lacunar infarcts, those patients (n=25) within the highest quartile of WMC were older, had more lacunar infarcts, more severe stroke, and lower prestroke cognitive function compared with those with less WMC. In addition, their performances in psychometric tests were significantly more impaired. Multivariate linear regression analysis revealed that WMC significantly influenced performance in MDRS I/P. WMC did not independently influence performance in MMSE and ADAS-cog.
  
  
  CONCLUSIONS
  Extent of WMC appears to be associated with executive dysfunction in stroke patients with lacunar infarcts. Further large prospective studies with extensive scales of executive function testing are required to confirm this issue.
authors.affiliation: Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
authors.forename: Hong Mei
authors.initials: HM
authors.lastname: Wen
authors.forename: Vincent C T
authors.initials: VC
authors.lastname: Mok
authors.forename: Yu Hua
authors.initials: YH
authors.lastname: Fan
authors.forename: Wynnie W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Wai Kwok
authors.initials: WK
authors.lastname: Tang
authors.forename: Adrian
authors.initials: A
authors.lastname: Wong
authors.forename: Ru Xun
authors.initials: RX
authors.lastname: Huang
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D020520:Brain Infarction / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D003072:Cognition Disorders / Q000209:etiology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D049292:Leukoaraiosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed