[Study of the correlation between drug exposure and blood concentration during cyclosporine microemulsion absorption phase in Chinese adult liver transplant recipients].
OBJECTIVE
To analyze the correlation between drug exposure (AUC0-4) and blood concentration of different sample points during Neoral absorption phase in Chinese adult liver transplant recipients, and to evaluate the possibility of using post-dose 2 hour level (C2) as a surrogate marker of AUC0-4 for the therapeutic drug monitoring (TDM) of Neoral.


METHODS
Neoral levels at 0, 1, 2, 3, and 4 hours (C1, C2, C3, C4) after morning dose of 22 de novo Chinese adult liver transplant recipients were monitored during different posttransplant periods. Liner regression was used to analyze the correlation between CsA concentration at different time points and the AUC0-4.


RESULTS
The best correlation was found at C2, while the correlation of C0 was the lowest. During following-up, the correlation between C2 and AUC0-4 was very stable.


CONCLUSIONS
C2 had the best correlation with drug exposure. This correlation is very stable. C2 may be used as a good surrogate marker of AUC0-4 for the TDM of Neoral.
Chen
Geng
G
Hepatobiliary Surgery Institute of Chinese P.L.A., Southwest Hospital, Third Military Medical University, Chongqing 400038, China.
He
Yu
Y
Chen
Yong-chuan
YC
Wang
Huai-zhi
HZ
Chen
Jian-hong
JH
Dong
Jia-hong
JH
D000328:Adult; D019540:Area Under Curve; D044466:Asian People; D016572:Cyclosporine / Q000097:blood* / Q000493:pharmacokinetics; D016903:Drug Monitoring / Q000379:methods; D004655:Emulsions; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood* / Q000493:pharmacokinetics; D007408:Intestinal Absorption / Q000502:physiology; D016031:Liver Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015166:Monitoring, Immunologic / Q000379:methods; D011184:Postoperative Period
D004655:Emulsions; D007166:Immunosuppressive Agents; D016572:Cyclosporine