title: Prolonged intraperitoneal versus extraperitoneal insufflation of carbon dioxide in patients undergoing totally endoscopic robot-assisted radical prostatectomy.
abstract: BACKGROUND
  Extraperitoneal laparoscopic prostatectomy is an alternative to the intraperitoneal method. However, the effects of extraperitoneal carbon dioxide (CO2) insufflation on hemodynamics and respiratory data have not been adequately studied. This study compared the effects of prolonged intra- and extraperitoneal CO2 insufflation on hemodynamics and gas exchange.
  
  
  METHODS
  For this study, 20 patients were assigned to receive totally endoscopic robot-assisted radical prostatectomy (TERP) via the intra- or extraperitoneal approach. Hemodynamic parameters and respiratory data were obtained during 8 h of insufflation and analyzed for statistical differences.
  
  
  RESULTS
  With both insufflation methods, arterial CO2 pressure increased rapidly, reaching higher levels with extraperitoneal insufflation. Therefore, patients managed with extraperitoneal insufflation required a significantly higher minute ventilation. Heart rate and central venous pressure increased in both groups, whereas mean arterial blood pressure and pH decreased.
  
  
  CONCLUSIONS
  Prolonged intra- and extraperitoneal CO2 insufflation for TERP resulted in significant, but mostly clinically unimportant, hemodynamic alterations. Carbon dioxide absorption was more pronounced with extraperitoneal insufflation.
authors.affiliation: Department of Anesthesiology, Intensive Care Medicine and Pain Control, J.W. Goethe-University Hospital, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany. dirk_meininger@gmx.de
authors.forename: D
authors.initials: D
authors.lastname: Meininger
authors.forename: C
authors.initials: C
authors.lastname: Byhahn
authors.forename: M
authors.initials: M
authors.lastname: Wolfram
authors.forename: S
authors.initials: S
authors.lastname: Mierdl
authors.forename: P
authors.initials: P
authors.lastname: Kessler
authors.forename: K
authors.initials: K
authors.lastname: Westphal
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000008:administration & dosage; D004724:Endoscopy; D006439:Hemodynamics; D006801:Humans; D007327:Insufflation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010529:Peritoneal Cavity; D011446:Prospective Studies; D012119:Respiration; D012371:Robotics; D020728:Transurethral Resection of Prostate / Q000379:methods*
chemical_list: D002245:Carbon Dioxide