title: Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032.
abstract: A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Riedlinger
authors.forename: Andreas
authors.initials: A
authors.lastname: Reicke
authors.forename: Hans
authors.initials: H
authors.lastname: Zähner
authors.forename: Bernhard
authors.initials: B
authors.lastname: Krismer
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bull
authors.forename: Luis A
authors.initials: LA
authors.lastname: Maldonado
authors.forename: Alan C
authors.initials: AC
authors.lastname: Ward
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Bojan
authors.initials: B
authors.lastname: Bister
authors.forename: Daniel
authors.initials: D
authors.lastname: Bischoff
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D010129:4-Aminobenzoic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D039903:Actinobacteria / Q000737:chemistry / Q000378:metabolism*; D024322:Amino Acids, Aromatic / Q000037:antagonists & inhibitors / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D018942:Macrolides / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010802:Phylogeny
chemical_list: D024322:Amino Acids, Aromatic; D000900:Anti-Bacterial Agents; D018942:Macrolides; D010129:4-Aminobenzoic Acid