Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity.
Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen. In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) beta-agonist, with those of estrogen. Genistein and 17beta-estradiol showed comparable levels of protection against Abeta-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17beta-estradiol, but not genistein, induced proliferation of uterine endometrial cells. Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.
Bang
Oh Young
OY
Department of Neurology, Suwon, South Korea.
Hong
Hyun Seok
HS
Kim
Dong Hyun
DH
Kim
Hee
H
Boo
Jung Hyun
JH
Huh
Kyoon
K
Mook-Jung
Inhee
I
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D005260:Female; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000819:agonists
D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D011960:Receptors, Estrogen; D019833:Genistein