Turning on the machine: genetic control of axon regeneration by c-Jun.
Upregulation of the transcription factor c-Jun has been correlated with axon regeneration after injury in multiple types of neurons. In this issue of Neuron, Raivich et al. use a nervous system-specific mutant to provide genetic evidence that c-Jun is necessary for efficient axon regeneration.
Zhou
Feng-Quan
FQ
Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Walzer
Mark A
MA
Snider
William D
WD
D000818:Animals; D001369:Axons / Q000502:physiology*; D020220:Facial Nerve Injuries / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D009416:Nerve Regeneration / Q000235:genetics*; D009420:Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D009473:Neuronal Plasticity / Q000235:genetics*; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics
D016755:Proto-Oncogene Proteins c-jun