Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice.
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
Lau
Gee W
GW
Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 6006, Cincinnati, OH 45267-0564, USA. gee.lau@uc.edu
Ran
Huimin
H
Kong
Fansheng
F
Hassett
Daniel J
DJ
Mavrodi
Dimitri
D
D000818:Animals; D008168:Lung / Q000382:microbiology* / Q000473:pathology; D008171:Lung Diseases / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D011710:Pyocyanine / Q000235:genetics / Q000378:metabolism*
D011710:Pyocyanine