title: Noise reduction using spatial-angular compounding for elastography.
abstract: Ultrasound elastography has developed into an imaging modality suitable for detection and diagnosis of cancers in the breast, prostate, and thyroid and for monitoring ablative therapies in the liver, kidneys, and other sites. In this article, a new approach is described that enables the reduction of noise artifacts in elastography without a significant reduction in either the contrast or spatial resolution. The technique uses angular-weighted compounding of local angular strains estimated from echo signals scanned at different insonification angles. Strain estimated along angular insonification directions can be separated into strain tensor components along the axial (direction of compression) and lateral directions. The mechanical stimulus is applied only along one direction. Angular-weighting factors are derived from the relationship between the axial and lateral strains under the assumption of tissue incompressibility. Experimental results using a uniformly elastic, tissue-mimicking phantom demonstrate the improvement in the signal-to-noise ratio obtained with angular-weighted compounding. Variation in the signal-to-noise ratio obtained using different angular increments also is investigated. Elastograms obtained from an inclusion phantom also demonstrate the improvement in contrast detail resolution obtained using spatial-angular compounding.
authors.affiliation: University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: Udomchai
authors.initials: U
authors.lastname: Techavipoo
authors.forename: Quan
authors.initials: Q
authors.lastname: Chen
authors.forename: Tomy
authors.initials: T
authors.lastname: Varghese
authors.forename: James A
authors.initials: JA
authors.lastname: Zagzebski
authors.forename: Ernest L
authors.initials: EL
authors.lastname: Madsen
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001940:Breast / Q000502:physiology*; D019245:Compressive Strength / Q000502:physiology; D004548:Elasticity; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D019047:Phantoms, Imaging; D010812:Physical Stimulation / Q000295:instrumentation / Q000379:methods; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D013269:Stochastic Processes; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods; D016217:Ultrasonography, Mammary / Q000295:instrumentation / Q000379:methods*