title: Early and late complications of radical retropubic prostatectomy: experience in a single institution.
abstract: BACKGROUND
  Radical retropubic prostatectomy is one of the first-line treatments for clinically organ-confined prostatic cancer. However, some studies have reported the morbidity of this procedure. We retrospectively assessed the incidence of complications of radical retropubic prostatectomy in our institution.
  
  
  METHODS
  We reviewed 123 consecutive medical charts of prostate cancer patients who underwent radical retropubic prostatectomy between 1988 and 2001 at our institution. We evaluated intraoperative complications, early complications within 1 month postoperatively, and late complications, including anastomotic stricture and urinary incontinence.
  
  
  RESULTS
  The median age of patients was 66 years (range, 53 to 74 years) and median follow-up duration was 44.0 months (range, 2 to 157 months). None of the patients died due to surgery-related causes. Intraoperative complications included rectal injuries in six patients (4.9%) and ureteral injury in one patient (0.8%). As for late complications, anastomotic strictures were observed in 16 patients (13.8%), and stress urinary incontinence that persisted for more than 12 months was observed in 13 patients. The estimated continence recovery rate at 12 months was 87.3%. Multivariate analysis did not reveal any predictive factor for anastomotic stricture. However, the blood loss volume and period of surgery were significant predictive factors of continence recovery.
  
  
  CONCLUSIONS
  Radical retropubic prostatectomy was safely performed, though there were various intra- or postoperative complications that were adequately managed. Early recovery of continence was related to the blood loss volume and the surgery period. Adequate surgical experience and a meticulous technique to avoid excessive bleeding are important factors for an early recovery.
authors.affiliation: Department of Urology, Sapporo Medical University, Sapporo, Japan.
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Hisasue
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kato
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Naoya
authors.initials: N
authors.lastname: Masumori
authors.forename: Naoki
authors.initials: N
authors.lastname: Itoh
authors.forename: Taiji
authors.initials: T
authors.lastname: Tsukamoto
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D007172:Erectile Dysfunction / Q000209:etiology*; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011183:Postoperative Complications; D011468:Prostatectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000601:surgery*; D012007:Rectum / Q000293:injuries; D012189:Retrospective Studies; D013997:Time Factors; D014513:Ureter / Q000293:injuries; D014549:Urinary Incontinence / Q000209:etiology*