title: (Z)-3,5,4'-Tri-O-methyl-resveratrol, induces apoptosis in human lymphoblastoid cells independently of their p53 status.
abstract: The pro-apoptotic ability of (Z)-3,5,4'-Tri-O-methyl-resveratrol (R3) was investigated in vitro on the human lymphoblastoid cell line TK6 and its p53-knockout counterpart (NH32). In both cell lines, R3 induced the stimulation of caspase-3. Although R3 induced growth inhibition and apoptosis of both cell lines, two distinct mechanisms were observed. The p53-knockout NH32 cells were shown to override the G2/M phase checkpoint with development of hyperdiploid cells, whereas TK6 cells accumulated at G2/M. As p53 function is often altered in human cancer cells, these results show that the pro-apototic effects of R3 against tumor cells are independent of their p53 status.
authors.affiliation: Laboratory of Nutritional Oncology, Inserm UMR S392, IRCAD, 1 place de l'Hôpital, BP 426, 67091 Strasbourg Cedex, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Schneider
authors.forename: Barbara
authors.initials: B
authors.lastname: Fischer
authors.forename: David
authors.initials: D
authors.lastname: Coelho
authors.forename: Stamatiki
authors.initials: S
authors.lastname: Roussi
authors.forename: Francine
authors.initials: F
authors.lastname: Gosse
authors.forename: Pierre
authors.initials: P
authors.lastname: Bischoff
authors.forename: Francis
authors.initials: F
authors.lastname: Raul
mesh_terms: D000840:Anisoles / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3; D020169:Caspases / Q000494:pharmacology; D018929:Cell Culture Techniques; D002453:Cell Cycle / Q000187:drug effects; D016158:Genes, p53 / Q000235:genetics*; D005818:Genetic Engineering; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000494:pharmacology
chemical_list: C497286:3,4',5-trimethoxystilbene; D000840:Anisoles; D013267:Stilbenes; D016159:Tumor Suppressor Protein p53; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases