title: Enhancement of the resolution of surface plasmon resonance biosensors by control of the size and distribution of nanoparticles.
abstract: A new resolution-enhanced surface plasmon resonance (SPR) biosensor offers a tenfold improvement in resolution compared with conventional SPR biosensors in the detection of the surface coverage of biomaterials. The proposed optical biosensor, based on the attenuated total-reflection method, excites both the surface plasmons and particle plasmons to enhance the local electromagnetic field by control of the size and volume fraction of embedded Au nanoparticles to increase the resolution of the device. The SPR biosensor design is based on the Maxwell-Garnett model and the Fresnel equations, and the device is fabricated with a cosputtering deposition system.
authors.affiliation: Department of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan. sheanjen@mail.ncku.edu.tw
authors.forename: S J
authors.initials: SJ
authors.lastname: Chen
authors.forename: F C
authors.initials: FC
authors.lastname: Chien
authors.forename: G Y
authors.initials: GY
authors.lastname: Lin
authors.forename: K C
authors.initials: KC
authors.lastname: Lee
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D003460:Crystallization / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006046:Gold / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009841:Oligonucleotides / Q000032:analysis* / Q000737:chemistry; D010316:Particle Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012834:Silver / Q000737:chemistry; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D009841:Oligonucleotides; D012834:Silver; D006046:Gold