Comparison of t-PA and u-PA levels in maximal treadmill and deep-water running.
BACKGROUND
The differences of urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA) between maximal treadmill and deep-water running have not been reported. The purpose of this investigation was to compare u-PA and t-PA levels during maximal treadmill and deep-water running.


METHODS
Six male subjects carried out two maximal exercises, one on a treadmill and the other running in deep water using a vest. The u-PA, t-PA, total plasminogen activator inhibitor (PAI-1), epinephrine, and norepinephrine in plasma and lactate and ammonia in blood concentrations were measured after maximal exercise.


RESULTS
The blood lactate and ammonia concentrations were significantly higher in treadmill running than in deep-water running during recovery following exercise (P < 0.05). At 1 min after exercise, the plasma epinephrine, norepinephrine levels, and the u-PA and t-PA levels were higher in treadmill running compared with that in deep-water running (P < 0.05). No significant difference between the two runs was found in PAI-1 level.


CONCLUSIONS
The maximal treadmill running induced a greater increase in u-PA and t-PA levels than maximal deep-water running.
Ohkuwa
Tetsuo
T
Department of General Studies, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan. ohkuwa.tetsuo@nitech.ac.jp
Itoh
Hiroshi
H
Yamamoto
Takako
T
Yamazaki
Yoshihiko
Y
D000328:Adult; D004837:Epinephrine / Q000097:blood; D005080:Exercise Test / Q000379:methods*; D006339:Heart Rate; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010960:Plasminogen Activators / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood*; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood*
D007773:Lactates; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; D009638:Norepinephrine; D004837:Epinephrine