Desymmetrization of a meso-diol complex derived from [Cr(CO)3(eta6-5,8-naphthoquinone)]: use of new diamine acylation catalysts.
[Cr(CO)3(naphthoquinone)](1), prepared in a three-step sequence starting from 1,4-dihydroxynaphthalene, was reduced to the corresponding meso-dihydronaphthalene syn-diol complex and the latter was desymmetrized to give the mono-acyl complex with 99% ee via asymmetric acylation catalyzed by the two new and easily accessed chiral diamines 7 and 8.
Kündig
E Peter
EP
Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland. Peter.Kundig@chiorg.unige.ch
Lomberget
Thierry
T
Bragg
Ryan
R
Poulard
Cyril
C
Bernardinelli
Gérald
G