title: Significance of the level of monocyte chemoattractant protein-1 in human atherosclerosis.
abstract: BACKGROUND
  Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant for monocytes, plays an important role in the earliest events of atherogenesis. However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic hemodialysis (HD) patients has not been reported.
  
  
  RESULTS
  The serum MCP-1 concentrations and the intimal - medial thickness (IMT) in the carotid arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched controls. The expression of MCP-1 was examined immunohistochemically in radial arterial tissues obtained from the HD patients. IMT and the serum concentration of MCP-1 in the HD patients were both significantly greater than in controls. Multiple regression analysis revealed that the serum concentration of MCP-1 was an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is expressed in both endothelial and smooth muscle cells and that its level of expression correlates with the serum concentration of MCP-1.
  
  
  CONCLUSIONS
  An increase in MCP-1 may be an important factor in the progression of atherosclerosis in non-diabetic HD patients.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. kfuku0218@aol.com
authors.forename: Kengo Fukushima
authors.initials: KF
authors.lastname: Kusano
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kusano
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishii
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Banba
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikeda
authors.forename: Katsushi
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Mika
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujio
authors.forename: Aya
authors.initials: A
authors.lastname: Miura
authors.forename: Keiko
authors.initials: K
authors.lastname: Ohta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Hironori
authors.initials: H
authors.lastname: Saito
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Emori
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Isao
authors.initials: I
authors.lastname: Kusano
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000097:blood* / Q000453:epidemiology; D016893:Carotid Stenosis / Q000453:epidemiology; D018932:Chemokine CCL2 / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D006435:Renal Dialysis; D012307:Risk Factors; D012907:Smoking
chemical_list: D018932:Chemokine CCL2