title: [Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children].
abstract: OBJECTIVE
  To study the association of dopamine beta-hydroxylase gene 5' flanking region polymorphism-1021 C-->T with attention deficit hyperactivity disorder (ADHD) in Han children.
  
  
  METHODS
  ADHD was diagnosed according to the DSM-IV criteria. DNA was extracted and PCR was performed to examine the DBH-1021C-->T polymorphism. HHRR was used to test the association of dopamine beta-hydroxylase gene with different subtypes of ADHD.
  
  
  RESULTS
  HHRR results showed this polymorphism had a tendency to be associated with the inattention subtype (P=0.067) and the combined subtype (P=0.076). The T allele was the protective factor of the inattentive subtype (P=0.07), and the risk factor of the combined subtype (P=0.08). After dividing the 292 nuclear families according to sex, DBH-1021C-->T polymorphism was found to be associated with the combined subtype (P=0.04) with the T allele as the risk factor (P=0.02). There were no positive findings among the girl nuclear families of ADHD.
  
  
  CONCLUSIONS
  DBH gene is related to ADHD combined subtype and inattention subtype. The genetic basis of ADHD combined subtype and is inattention is different, and is influenced by sex factor.
authors.affiliation: Mental Health Institute of Peking University, Beijing 100083, China.
authors.forename: Hao-bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002648:Child; D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D004299:Dopamine beta-Hydroxylase