title: [Unrelated HLA-matched donor marrow transplantation for one case of myelodysplastic syndrome].
abstract: To explore feasibility and efficacy of unrelated HLA matched donor marrow transplantation in treatment of myelodysplastic syndrome, one case (male, 31 years old) of myelodysplastic syndrome-refractory cytopenia with multilineage dysplasia (MDS-RCMD) has been received unrelated HLA-matched donor transplantation. Busulfan, cyclophosphamide, Ara-C, MeCCNU and antithymocyte globulin (ATG) were used for preparative regimen. Mycophenolate mofetile, cyclosporin A and short-term methotrexate were used for graft-versus-host disease prophylaxis. The results showed that neutrophil of > 0.5 x 10(9)/L, platelet of 58 x 10(9)/L and hemoglobin of 114 g/L were observed at 10, 20 days and 3 months respectively post transplantation. Disease-free survival without GVHD was 9 months. In conclusion, unrelated HLA matched donor marrow transplantation is an effective approach for treatment of patients with MDS.
authors.affiliation: Department of Hematology, General Hospital PLA, Beijing 100853, China. gaochunji@hotmail.com
authors.forename: Chun-Ji
authors.initials: CJ
authors.lastname: Gao
authors.forename: Wan-Ming
authors.initials: WM
authors.lastname: Da
authors.forename: Bo-Long
authors.initials: BL
authors.lastname: Zhang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Han
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhu
authors.forename: Hai-Jie
authors.initials: HJ
authors.lastname: Jin
authors.forename: Yu
authors.initials: Y
authors.lastname: Jing
authors.forename: Wen-Rong
authors.initials: WR
authors.lastname: Huang
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology; D006410:Hematopoiesis; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000628:therapy*