title: Synthesis of the thapsigargins.
abstract: The thapsigargins are a family of complex guaianolides with potent and selective Ca(2+)-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom. svl1000@cam.ac.uk
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
authors.forename: Alessandra
authors.initials: A
authors.lastname: Antonello
authors.forename: Emily P
authors.initials: EP
authors.lastname: Balskus
authors.forename: David T
authors.initials: DT
authors.lastname: Booth
authors.forename: Søren B
authors.initials: SB
authors.lastname: Christensen
authors.forename: Ed
authors.initials: E
authors.lastname: Cleator
authors.forename: Helen
authors.initials: H
authors.lastname: Gold
authors.forename: Klemens
authors.initials: K
authors.lastname: Högenauer
authors.forename: Udo
authors.initials: U
authors.lastname: Hünger
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Myers
authors.forename: Steven F
authors.initials: SF
authors.lastname: Oliver
authors.forename: Oliver
authors.initials: O
authors.lastname: Simic
authors.forename: Martin D
authors.initials: MD
authors.lastname: Smith
authors.forename: Helmer
authors.initials: H
authors.lastname: Søhoel
authors.forename: Alison J A
authors.initials: AJ
authors.lastname: Woolford
mesh_terms: D019661:Apiaceae / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D015394:Molecular Structure; D013237:Stereoisomerism; D019284:Thapsigargin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D001688:Biological Products; D019284:Thapsigargin