Anti-inflammatory cyathane diterpenoids from Sarcodon scabrosus.
Four novel diterpenoids were isolated from the fruiting bodies of Sarcodon scabrosus (Fr.) Karst. (Boraginaceae) together with neosarcodonin A. One of the novel compounds was elucidated to be a cyathane diterpenoid, namely neosarcodonin O, by its spectral data. The others were characterized as 19-O-linoleoyl, 19-O-oleoyl and 19-O-stearoyl derivatives of sarcodonin A, after comparison with the authentic samples synthetically prepared from sarcodonin A. These compounds, together with the five 19-O-acyl derivatives synthesized from sarcodonin A, each exhibited inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation on mouse ears by topical application.
Kamo
Tsunashi
T
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, Gifu, Japan.
Imura
Yuki
Y
Hagio
Tomomi
T
Makabe
Hidefumi
H
Shibata
Hisao
H
Hirota
Mitsuru
M
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D028082:Boraginaceae / Q000737:chemistry*; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D013729:Terpenes
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D013729:Terpenes; C117589:sarcodonin M