title: [Study on the injury effect of ammonium perchlorate to lung].
abstract: OBJECTIVE
  To study the injury effect of ammonium perchlorate (AP) to lung and to explore whether AP can cause pulmonary fibrosis.
  
  
  METHODS
  To detect the levels of cell counts, TNF-alpha, MDA, HYP and the synthesis of collagen in BALF or rat lung after a certain time when rats were injected AP by intratracheal instillation.
  
  
  RESULTS
  AP could bring about acute lung damage and inflammatory reaction. The levels of TNF-alpha of different groups in different time were obviously higher than the normal control group(P < 0.05). AP could affect the levels of MDA, HYP and the synthesis of collagen. But it had no obviously pathological change of pulmonary fibrosis.
  
  
  CONCLUSIONS
  There were acute injury effect about AP to lung, but this experiment could not make sure whether AP could cause pulmonary fibrosis.
authors.affiliation: Public Health School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
authors.forename: Haibing
authors.initials: H
authors.lastname: Yang
authors.forename: Kailiang
authors.initials: K
authors.lastname: Peng
authors.forename: Qilong
authors.initials: Q
authors.lastname: Chu
authors.forename: Suli
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008315:Malondialdehyde / Q000032:analysis; D010472:Perchlorates / Q000633:toxicity*; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D010472:Perchlorates; D000644:Quaternary Ammonium Compounds; D014409:Tumor Necrosis Factor-alpha; D008315:Malondialdehyde; D006909:Hydroxyproline; C053506:ammonium perchlorate