title: Upregulation of cytochrome P450 1A2 in chronic renal failure: does oxidized tryptophan play a role?
abstract: Earlier studies from this laboratory have shown that L-tryptophan, after oxidation by either UV-irradiation or ozone induces aryl hydrocarbon receptor (AhR) transformation and binding of the liganded AhR complex to its specific DNA recognition site, thereby inducing transcription of Cyp1a1 gene with concomitant increase of CYP1A1 protein and activity in cells in culture. In the present investigation, we investigated the expression of CYP1A2 in the liver and kidney in chronic renal failure (CRF). The results demonstrate that CYP1A2 protein abundance was upregulated in both the liver and kidney tissues of the CRF group compared to the sham-operated controls.
authors.affiliation: Division of Nephrology/Hypertension, Department of Medicine, University of California at Irvine, Irvine, CA 92697-4066, USA. rksindhu@uci.edu
authors.forename: Ram K
authors.initials: RK
authors.lastname: Sindhu
authors.forename: Nosratola D
authors.initials: ND
authors.lastname: Vaziri
mesh_terms: D000818:Animals; D019388:Cytochrome P-450 CYP1A2 / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D051547:Heme Oxygenase-1; D007668:Kidney / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D014364:Tryptophan / Q000737:chemistry / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D014364:Tryptophan; D019388:Cytochrome P-450 CYP1A2; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C105245:heme oxygenase-2