title: Prostaglandin E1 induces intraosseous hypotension under conditions of normal arterial pressure.
abstract: The purpose of this study was to investigate the late effects of intravenous infusion of prostaglandin E1 (PGE1) on intraosseous pressure (IOP). PGE1 was infused intravenously at 0, 0.1, 0.3 or 1.0 microg/kg/min over 120 min daily for 5 consecutive days into six rabbits each. On the day after the final infusion, mean (SD) change from baseline in IOP of the tibia was 14.5 (22.6), -10.6 (29.6), -29.8 (22.2) and -6.9 (22.5) percent in the groups infused at 0, 0.1, 0.3 and 1.0 microg/kg/min, respectively, being significantly different between the groups infused at 0 and 0.3 microg/kg/min. The mean change from baseline in mean arterial pressure (MAP) was not significantly different between the four groups. There was no significant correlation between percent changes from baseline in IOP and MAP in all the 24 rabbits from the four groups (r = 0.197, P = 0.362 ). In conclusion, IOP decreases following repeated PGE1 infusion independent of MAP change when the dose is appropriate.
  
  
  CONCLUSIONS
  Intraosseous hypotension induced under conditions of normal arterial pressure contributes to systemic control of intraoperative bleeding from the bone.
authors.affiliation: Department of Orthopaedic Surgery, Osaka Police Hospital, 10-31 Kitayama-cho, Tennoji-ku, Osaka 543-0035, Japan. kakiuchi@sutv.zaq.ne.jp
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kakiuchi
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D011817:Rabbits; D013977:Tibia / Q000098:blood supply* / Q000187:drug effects* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D000527:Alprostadil