title: The nervous system and chronic kidney disease in children.
abstract: This paper provides a review of the literature on the nervous system involvement incurred by children and adolescents with chronic kidney disease (CKD), with a particular focus on neuropsychological functioning. In addition to an historical overview of earlier literature, published studies from the past 14 years that address both central and peripheral nervous system function in children with CKD are reviewed (1990-2003). These studies span work in neuroimaging, electrophysiology, and neuropsychology. A key focus for this review is on variables that might affect neurodevelopmental status in these children. The paper concludes with suggestions for achieving progress in the understanding of this complication of kidney disease in children.
authors.affiliation: Division of Nephrology and Hypertension, University of North Carolina, 349 MacNider Hall, Campus Box 7155, NC 27599-7155, Chapel Hill, USA. debbie_gipson@med.unc.edu
authors.forename: Debbie S
authors.initials: DS
authors.lastname: Gipson
authors.forename: Crista E
authors.initials: CE
authors.lastname: Wetherington
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Duquette
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Hooper
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000150:complications / Q000503:physiopathology*; D009420:Nervous System / Q000254:growth & development / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000209:etiology