Short-step synthesis of chenodiol from stigmasterol.
Chenodiol is an important bile acid widely used for gallstone dissolution and cholestatic liver diseases. We succeeded in a short-step synthesis of chenodiol, starting from the safer phytosterol, stigmasterol.
Uekawa
Toru
T
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Ishigami
Ken
K
Kitahara
Takeshi
T
D002635:Chenodeoxycholic Acid / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010840:Phytosterols / Q000737:chemistry; D013265:Stigmasterol / Q000737:chemistry
D007202:Indicators and Reagents; D010840:Phytosterols; D002635:Chenodeoxycholic Acid; D013265:Stigmasterol