title: Significance of missed polyps at CT colonography.
abstract: OBJECTIVE
  Our purpose was to determine the clinical significance of polyps missed on CT colonography using histologic analysis and the natural history of colorectal polyps and to propose guidelines for follow-up colon surveillance based on CT colonographic findings. SUBJECTS AND METHODS. One hundred eighty-six men (age range, 40-87 years; mean, 62.3 years) underwent CT colonography immediately before conventional colonoscopy. All polyps detected on CT colonography were measured and imaged, and their segmental location was documented. All polyps detected on colonoscopy were measured, photographed, biopsied, and histologically analyzed. Results of CT colonography and conventional colonoscopy were compared with the final pathology reports. Conventional colonoscopy was used as the gold standard unless CT colonography showed a lesion measuring 10 mm or more that was not detected on conventional colonoscopy and had characteristics of a polyp. In these cases, follow-up conventional colonoscopy was offered.
  
  
  RESULTS
  One hundred ninety-one polyps were detected on conventional colonoscopy. CT colonography prospectively detected 53 polyps. Histologic analysis of the polyps not detected on CT colonography showed that of those 5 mm or smaller, 58.1% were not adenomas, and of those measuring 6-9 mm, 42.8% were not adenomas. Both missed polyps at CT colonography of 10 mm or more were adenomas. Of the 22 polyps measuring 10 mm or more, three were not detected on conventional colonoscopy. Of these three, CT colonography showed a lesion having characteristics of a polyp, follow-up endoscopy confirmed the presence of the lesion, and histologic analysis showed a villous adenoma, a tubulovillous adenoma, and a tubular adenoma.
  
  
  CONCLUSIONS
  If CT colonography shows no abnormality, follow-up screening in 5 years is recommended. If CT colonography detects a lesion smaller than 5 mm, follow-up imaging in 3-5 years is recommended. If CT colonography detects a lesion measuring 6 mm or more, endoscopy and polypectomy should be offered unless contraindicated.
authors.affiliation: Department of Radiology, Abdominal Imaging, NYU Medical Center, Tisch Hospital, 560 First Ave., Ste. HW 207, New York, NY 10016, USA. michael.macari@med.nyu.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Macari
authors.forename: Edmund J
authors.initials: EJ
authors.lastname: Bini
authors.forename: Stacy L
authors.initials: SL
authors.lastname: Jacobs
authors.forename: Yvonne W
authors.initials: YW
authors.lastname: Lui
authors.forename: Shaked
authors.initials: S
authors.lastname: Laks
authors.forename: Andrew
authors.initials: A
authors.lastname: Milano
authors.forename: James
authors.initials: J
authors.lastname: Babb
mesh_terms: D003111:Colonic Polyps / Q000000981:diagnostic imaging*; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging; D013997:Time Factors