A canine model for production of severe unilateral panacinar emphysema.
The authors created a canine model of severe emphysema using whole lung lavage to deliver repeated porcine pancreatic elastase solution to the terminal airways and alveoli of the right lung. This model produces extreme unilateral panacinar emphysema closely resembling that encountered in patients with alpha1-antitrypsin deficiency. Because the contralateral lung remains functional, the animals can be maintained indefinitely. The model will be of value in developing imaging techniques capable of safely evaluating the effect of treatment on panacinar emphysema in alpha1-antitrypsin-deficient patients.
Chino
Kimiaki
K
Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Choong
Cliff K
CK
Toeniskoetter
P Diane
PD
Cooper
Joel D
JD
Lausberg
Henning F
HF
Bae
Kyongtae T
KT
Pierce
John A
JA
Hogg
James C
JC
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D005652:Functional Residual Capacity; D008168:Lung / Q000187:drug effects / Q000473:pathology; D010196:Pancreatic Elastase / Q000378:metabolism / Q000494:pharmacology*; D011656:Pulmonary Emphysema / Q000139:chemically induced* / Q000473:pathology*
D010196:Pancreatic Elastase