[Efficacy of hepatitis B vaccination on hepatitis B prevention and on hepatocellular carcinoma].
OBJECTIVE
To evaluate the efficacy of hepatitis B vaccination on hepatitis B prevention and on hepatocellular carcinoma.


METHODS
Birth cohort study, cross-sectional seroepidemiological survey, and surveillance of hepatitis B (HBV) and hepatocellular carcinoma were used to evaluate the efficacy of hepatitis B vaccination.


RESULTS
During the 14 years after hepatitis B vaccination, the HBsAg positive rates were found to be 0.7% - 2.9%, with an average of 1.5%, and the protective rates were 83.5% - 96.6%. Hepatitis B virus infection rates of children immunized with hepatitis B vaccine were 1.1% - 5.1%, with an average of 2.2% and the protective rates of 93.5% - 98.4%. 15 years after hepatitis B vaccination, the incidence of hepatitis B dropped from 3.27/10 000 to 0.17/10 000, a 94.8% decrease, in the group of 0 - 19 year-olds.


CONCLUSIONS
The universal infant hepatitis B vaccination has proved to be effective in reducing the incidence rate of acute hepatitis B as well as the mortality of hepatocellular carcinoma.
Li
Rong-cheng
RC
Center for Disease Prevention and Control, Guangxi Zhuangzu Autonimous Region, Nanning 530021, China.
Yang
Jin-ye
JY
Gong
Jian
J
Li
Yan-ping
YP
Huang
Zhao-neng
ZN
Fang
Kong-xiong
KX
Xu
Zhi-yi
ZY
Liu
Chong-bai
CB
Zhao
Kai
K
Zhuang
Hui
H
D000293:Adolescent; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D006509:Hepatitis B / Q000453:epidemiology / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D008113:Liver Neoplasms / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D008875:Middle Aged; D015995:Prevalence; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic