title: A human cellular protein activity (OF-1), which binds herpes simplex virus type 1 origin, contains the Ku70/Ku80 heterodimer.
abstract: In an effort to identify host proteins involved in herpes simplex virus type 1 replication, monkey and human cellular protein activities (called OF-1) that bind the viral replication origin, oriS, have been described. We show by mass spectrometry that the DNA-binding component of human OF-1 contains Ku70 and Ku80 proteins.
authors.affiliation: Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Murata
authors.forename: Mark S
authors.initials: MS
authors.lastname: Dodson
authors.forename: Jennifer D
authors.initials: JD
authors.lastname: Hall
mesh_terms: D000595:Amino Acid Sequence; D034961:Antigens, Nuclear / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D019281:Dimerization; D018259:Herpesvirus 1, Human / Q000502:physiology; D006801:Humans; D000072200:Ku Autoantigen; D008969:Molecular Sequence Data; D018741:Replication Origin / Q000235:genetics / Q000502:physiology*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods; D014764:Viral Proteins / Q000378:metabolism; D014779:Virus Replication
chemical_list: D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; C414566:OF-1 protein; D014764:Viral Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen