Percutaneous sclerotherapy of renal cysts with a beta-emitting radionuclide, holmium-166-chitosan complex.
OBJECTIVE
To evaluate the usefulness of a beta-emitting radionuclide (holmium-166-chitosan complex) as a sclerosing agent for the treatment of renal cysts.


METHODS
Using 10-30 mCi of holmium-166-chitosan complex, 20 renal cysts in 17 patients (14 male and 3 female patients, ranging in age from 47 to 82 years) were treated by percutaneous sclerotherapy under ultrasonographic guidance. The volume of the cysts before and after the sclerotherapy and the percentage change in volume were calculated in order to evaluate the response to therapy, which was classified as either complete regression (invisible), nearly complete regression (< 15 volume% of initial volume), partial regression (15-50 volume%) or no regression (> 50 volume%).


RESULTS
The follow-up period ranged from 6 to 36 months (mean 28 months). Eighteen cysts (90%) regressed completely (n=11, 55%) or near-completely (n=7, 35%). Partial regression was obtained in one patient (5%) and there was no regression in one patient (5%). No significant complications were encountered.


CONCLUSIONS
The holmium-166-chitosan complex seems to be useful as a new painless sclerosing agent for the treatment of renal cysts with no significant complications.
Kim
Joo Hee
JH
Department of Diagnostic Radiology, Research Institute of Radiological Science, Seoul, Republic of Korea. jtlee@yumc.yonsei.ac.kr
Lee
Jong Tae
JT
Kim
Eun Kyung
EK
Won
Jong Yoon
JY
Kim
Myeong-Jin
MJ
Lee
Jong Doo
JD
Hong
Sung Joon
SJ
D000368:Aged; D000369:Aged, 80 and over; D002686:Chitin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006695:Holmium / Q000627:therapeutic use*; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D015911:Sclerotherapy
C116411:DW 166HC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D002686:Chitin; D006695:Holmium