[Usefulness of urinary trypsinogen-2 dipstick test for diagnosis of acute pancreatitis].
OBJECTIVE
The clinical usefulness of urinary trypsinogen-2 dipstick test is still in controversy. We evaluated the usefulness of urinary trypsinogen-2 dipstick test in patients with acute pancreatitis.


METHODS
Urinary trypsinogen-2 dipstick test was prospectively performed in 50 patients with acute pancreatitis, 50 patients with non-pancreatic abdominal pain, and 50 healthy controls.


RESULTS
On admission, urinary trypsinogen-2 dipstick test was positive in 36 of 50 patients with acute pancreatitis (sensitivity, 72%) and in 4 of 50 patients with non-pancreatic abdominal pain (specificity, 92%). On the other hand, it was all negative in controls. The sensitivity and specificity of serum lipase were 78% and 94%, respectively. At 24 hours after admission, the positive rate of urinary trypsinogen-2 dipstick test rose from 72% to 94% (p=0.02). The results of urinary trypsinogen-2 dipstick test was positive in 14 of 15 patients with severe pancreatitis and 22 of 35 patients with mild pancreatitis according to the criteria by Atlanta International Symposium, 1992.


CONCLUSIONS
Urinary trypsinogen-2 dipstick test is comparable to serum lipase in diagnosing acute pancreatitis. Delayed measurement and severe pancreatitis are more likely to yield positive results with urinary trypsinogen-2 dipstick test. Thus, we suggest that the cut-off value of urinary trypsinogen-2 dipstick test should be lowered to increase its sensitivity.
Hwang
Seoung Joon
SJ
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Chung
Jun Pyo
JP
Kim
Young Gyun
YG
Song
Dae Hoon
DH
Lee
Jae Sung
JS
Baek
Seung Seok
SS
Kim
Do Yun
DY
Lee
Dok Yong
DY
Jeong
Yon Soo
YS
Ji
Sang Won
SW
Lee
Se Joon
SJ
Song
Si Young
SY
Lee
Kwan Sik
KS
Chung
Jae Bock
JB
Lee
Sang In
SI
Kang
Jin Kyung
JK
Park
Jun Seog
JS
Cho
Kwang Hyun
KH
D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis*; D011934:Reagent Strips; D012680:Sensitivity and Specificity; D014362:Trypsinogen / Q000652:urine*
D015415:Biomarkers; D011934:Reagent Strips; D014362:Trypsinogen; D008049:Lipase