title: Synthesis of new coumarin 3-(N-aryl) sulfonamides and their anticancer activity.
abstract: Synthesis of coumarin 3-(N-aryl) sulfonamides was accomplished either by Knoevenagel condensation of anilinosulfonylacetic acids with suitable salicylaldehydes or by the reaction of methyl anilinosulfonylacetates with substituted salicylaldehydes in presence of a catalytic amount of a base. All the compounds tested for antiproliferative activity in different cancer cell lines have shown GI(50) values less than 100 microM.
authors.affiliation: Fels Institute for Cancer Research, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140-5101, USA.
authors.forename: Natala Srinivasa
authors.initials: NS
authors.lastname: Reddy
authors.forename: Muralidhar Reddy
authors.initials: MR
authors.lastname: Mallireddigari
authors.forename: Stephen
authors.initials: S
authors.lastname: Cosenza
authors.forename: Kiranmai
authors.initials: K
authors.lastname: Gumireddy
authors.forename: Stanley C
authors.initials: SC
authors.lastname: Bell
authors.forename: E Premkumar
authors.initials: EP
authors.lastname: Reddy
authors.forename: M V Ramana
authors.initials: MV
authors.lastname: Reddy
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D003374:Coumarins / Q000138:chemical synthesis / Q000633:toxicity; D006801:Humans; D020014:K562 Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D013449:Sulfonamides