Mpdz is a quantitative trait gene for drug withdrawal seizures.
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
Shirley
Renee L
RL
Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health & Science University, and the Department of Veterans Affairs Medical Center, 3181 SW Sam Jackson Park Road, mailcode L-470, Portland, Oregon 97239-3098, USA.
Walter
Nicole A R
NA
Reilly
Matthew T
MT
Fehr
Christoph
C
Buck
Kari J
KJ
D000818:Animals; D001522:Behavior, Animal; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D003001:Cloning, Molecular / Q000379:methods; D004622:Embryo, Mammalian; D000431:Ethanol; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D005838:Genotype; D008565:Membrane Proteins; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D040641:Quantitative Trait Loci / Q000235:genetics*; D012640:Seizures / Q000209:etiology / Q000235:genetics*; D013375:Substance Withdrawal Syndrome / Q000150:complications / Q000235:genetics*
D002352:Carrier Proteins; D008565:Membrane Proteins; C491750:Mpdz protein, mouse; D000431:Ethanol