Immunohistochemical examination of P-cadherin in bullous and acantholytic skin diseases.
Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cellular connection between normal cells. P-cadherin is involved in the selective adhesion of epidermal cells, and is expressed only on the surfaces of the two basal layers. We examined the expression of P-cadherin in some autoimmune bullous skin diseases and Darier's disease using immunohistochemistry and found P-cadherin to be strongly upregulated. We believe the upregulation is compensatory to the primary pathophysiological events in the various bullous dermatoses.
Kovács
Anikó
A
Departament of Dermatology, University of Debreen, Medical and Health Science Centre, Faculty of General Medicine, Hungary. Aniko.Kovacs@vgregion.se
Schmidt
Emese
E
Bégány
Agnes
A
Hunyadi
János
J
Szegedi
Andrea
A
D000051:Acantholysis / Q000276:immunology / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D001707:Biopsy, Needle; D015820:Cadherins / Q000032:analysis / Q000378:metabolism*; D007644:Darier Disease / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D016253:Microscopy, Immunoelectron; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000473:pathology; D010392:Pemphigus / Q000276:immunology / Q000473:pathology; D012016:Reference Values; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology* / Q000473:pathology*; D015854:Up-Regulation
D015415:Biomarkers; D015820:Cadherins