title: [Successful induction and complete improvement of myelofibrosis and erythema nosodum with cladribine in a case of hairy cell leukemia].
abstract: The patient was a 45-year-old male who had been diagnosed with pancytopenia in 1998 at another hospital, where he continued treatment for idiopathic thrombocytopenic purpura (ITP) as an outpatient. After atypical lymphocytes were detected in his peripheral blood, he was admitted to our hospital for further examination in April 2002. Tests results revealed the additional existence of pancytopenia, splenomegaly, bone marrow fibrosis and erythema nodosum, in addition to the findings of surface marker. Tartrate resistant acid phosphatase (TRAP) staining and scanning electron microscopy of peripheral blood lymphocytes indicated hairy cell leukemia. After administration of cladribine (0.09 mg/kg) for 7 days, complete remission was obtained, with bone marrow fibrosis and erythema nodosum also being completely improved.
authors.affiliation: Fourth Dept. of Internal Medicine, School of Medicine, Sapporo Medical University.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Araki
authors.forename: Takuya
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Murase
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Kageaki
authors.initials: K
authors.lastname: Kuribayashi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terui
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Niitsu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017338:Cladribine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004893:Erythema Nodosum / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000150:complications; D055728:Primary Myelofibrosis / Q000150:complications / Q000188:drug therapy*; D012074:Remission Induction; D013163:Splenomegaly / Q000150:complications
chemical_list: D000970:Antineoplastic Agents; D017338:Cladribine