Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition.
Event-related oscillations (ERO) offer an alternative theoretical and methodological approach to the analysis of event-related EEG responses. The P300 event-related potential (ERP) is elicited through the superposition of the delta (1-3 Hz) and theta (3-7 Hz) band oscillatory responses. The cholinergic neurotransmitter system has a key function in modulating excitatory post-synaptic potentials caused by glutamate, and therefore influences P300 generation and the underlying oscillatory responses. Here we report significant linkage and linkage disequilibrium between target case frontal theta band, visual evoked brain oscillations and a single nucleotide polymorphism (SNP) from the cholinergic muscarinic receptor gene (CHRM2) on chromosome 7. We also demonstrate significant linkage disequilibrium between CHRM2 SNPs and target case parietal delta band visual evoked oscillations (LD P<0.001). These findings were not observed for the equivalent non-target case data, suggesting a role for the CHRM2 gene in higher cognitive processing in humans.
Jones
Kevin A
KA
Department of Psychiatry, Neurodynamics Laboratory, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA.
Porjesz
Bernice
B
Almasy
Laura
L
Bierut
Laura
L
Goate
Alison
A
Wang
Jen C
JC
Dick
Danielle M
DM
Hinrichs
Anthony
A
Kwon
Jennifer
J
Rice
John P
JP
Rohrbaugh
John
J
Stock
Heather
H
Wu
William
W
Bauer
Lance O
LO
Chorlian
David B
DB
Crowe
Raymond R
RR
Edenberg
Howard J
HJ
Foroud
Tatiana
T
Hesselbrock
Victor
V
Kuperman
Samuel
S
Nurnberger
John
J
O'Connor
Sean J
SJ
Schuckit
Marc A
MA
Stimus
Arthur T
AT
Tischfield
Jay A
JA
Reich
Theodore
T
Begleiter
Henri
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D003071:Cognition; D003700:Delta Rhythm; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D005625:Frontal Lobe / Q000503:physiopathology; D008040:Genetic Linkage; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D009991:Oscillometry; D010296:Parietal Lobe / Q000503:physiopathology; D020641:Polymorphism, Single Nucleotide; D043585:Receptor, Muscarinic M2 / Q000235:genetics*; D013826:Theta Rhythm
C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2