[Level of soluble tumor necrosis factor receptor type I in patients with systemic scleroderma].
OBJECTIVE
To study content and clinical correlations of sTNF-RI in patients with systemic sclerosis (SS).


METHODS
Thirty nine SS patients were examined with enzyme immunoassay for serum levels of sTNF-RI and soluble adhesion molecules (sSAM) sVSAM-1, sISAM-1 and sR-selectine using R&D System kits (USA). The control group consisted of 14 healthy subjects (donors). Content of sTNF-RI and sSAM was considered as elevated if it exceeded relevant mean values by 1SD.


RESULTS
sTNF-RI content was significantly higher in the patients than in the controls (p = 0.0001) and was similar in patients with diffuse and limited forms of the disease. A rise in sTNF-RI correlated with a rise in pulmonary artery pressure. In patients with pulmonary hypertension or restrictive pulmonary affection sTNF-RI was higher than in patients free of pulmonary hypertension or impaired external respiration function. A marked correlation was found between sTNF-RI and sVSAM-1. Patients with high CRP had significantly higher sTNF-RI level than patients with normal CRP.


CONCLUSIONS
SS is characterized by elevated content of sTNF-RI. This content may serve a diagnostic marker of the disease progression.
Alekperov
R T
RT
Timchenko
A V
AV
Samsonov
M Iu
MIu
Guseva
N G
NG
Nasonov
E L
EL
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D012595:Scleroderma, Systemic / Q000097:blood* / Q000150:complications
D015415:Biomarkers; D047888:Receptors, Tumor Necrosis Factor, Type I