Group A streptococcal infections of the pharynx in a rural population in south India.
OBJECTIVE
There has been a resurgence in the incidence of rheumatic heart disease all over the world and hence surveillance and strain characterization are important. The aim of this study was to screen children in a rural community in south India for throat carriage of group A streptococci and to clinically assess them for signs of rheumatic heart disease.


METHODS
Throat swabs were collected from children (5-14 yr) in the village of Orathur, Tamil Nadu and cultured on tryptose blood agar plates. Beta haemolytic streptococci were serogrouped using Streptex kit and biotyped based on their ability to ferment carbohydrates and production of beta-glucuronidase enzyme. Blood samples were also collected and antibodies to streptolysin O demonstrated by latex agglutination tests. All the children were examined by a paediatrician; ECG and echocardiography were performed to assess cardiac function.


RESULTS
Eighty of the 310 children included in the study had symptoms of acute respiratory infections; 16 of them grew beta haemolytic streptococci of which 8 belonged to group A (10%). Biotype 4 was most common. Antistreptolysin O (ASO) test did not correlate with culture results. Two of 310 children had rheumatic heart disease but both were culture negative.


CONCLUSIONS
Pharyngeal carriage of group A streptococci was common in this population. The prevalence of rheumatic heart disease was 0.6 per cent. The study emphasizes the need for active surveillance and characterization of GAS isolates.
Menon
Thangam
T
Department of Microbiology, Dr ALM PGIBMS, University of Madras, Chennai, India. thangam16@rediffmail.com
Shanmugasundaram
S
S
Kumar
M Palani
MP
Kumar
C P Girish
CP
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007194:India / Q000453:epidemiology; D010612:Pharyngitis / Q000453:epidemiology* / Q000382:microbiology; D012424:Rural Population; D013290:Streptococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000302:isolation & purification*