Oxamides as novel NR2B selective NMDA receptor antagonists.
A novel series of oxamides derived from indole-2-carboxamides was identified as potent NR2B selective NMDA receptor antagonists. Several members of this group showed good analgesic activity in the mouse formalin test.
Barta-Szalai
Gizella
G
Gedeon Richter Ltd, 10, PO Box 27, H-1475 Budapest, Hungary.
Borza
István
I
Bozó
Eva
E
Kiss
Csilla
C
Agai
Béla
B
Proszenyák
Agnes
A
Keseru
György M
GM
Gere
Anikó
A
Kolok
Sándor
S
Galgóczy
Kornél
K
Horváth
Csilla
C
Farkas
Sándor
S
Domány
György
G
D000818:Animals; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D015394:Molecular Structure; D016202:N-Methylaspartate / Q000494:pharmacology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D007211:Indoles; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate