title: Hypercholesterolaemia in a family of rough collie dogs.
abstract: A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha-2 high density lipoprotein-1 band and was due to an increase in the cholesterol content of the very low density lipoprotein, low density lipoprotein and possibly the high density lipoprotein-1 fractions. A low-fat and energy-restricted diet did not reduce either total cholesterol or the corneal lipidosis. Corneal lipidosis regressed with short-chain fructo-oligosaccharide supplementation. However, the effects of short-chain fructo-oligosaccharides on total cholesterol were transient and variable.
authors.affiliation: Animal Nutrition Unit, Veterinary Faculty, University of Liege, B-4000 Liege, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Jeusette
authors.forename: M
authors.initials: M
authors.lastname: Grauwels
authors.forename: C
authors.initials: C
authors.lastname: Cuvelier
authors.forename: C
authors.initials: C
authors.lastname: Tonglet
authors.forename: L
authors.initials: L
authors.lastname: Istasse
authors.forename: M
authors.initials: M
authors.lastname: Diez
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D006937:Hypercholesterolemia / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D008297:Male; D010375:Pedigree
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D002784:Cholesterol