title: PredictRegulon: a web server for the prediction of the regulatory protein binding sites and operons in prokaryote genomes.
abstract: An interactive web server is developed for predicting the potential binding sites and its target operons for a given regulatory protein in prokaryotic genomes. The program allows users to submit known or experimentally determined binding sites of a regulatory protein as ungapped multiple sequence alignments. It analyses the upstream regions of all genes in a user-selected prokaryote genome and returns the potential binding sites along with the downstream co-regulated genes (operons). The known binding sites of a regulatory protein can also be used to identify its orthologue binding sites in phylogeneticaly related genomes where the trans-acting regulator protein and cognate cis-acting DNA sequences could be conserved. PredictRegulon can be freely accessed from a link on our world wide web server: http://www.cdfd.org.in/predictregulon/.
authors.affiliation: Computational & Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad 500076, India.
authors.forename: Sailu
authors.initials: S
authors.lastname: Yellaboina
authors.forename: Jayashree
authors.initials: J
authors.lastname: Seshadri
authors.forename: M Senthil
authors.initials: MS
authors.lastname: Kumar
authors.forename: Akash
authors.initials: A
authors.lastname: Ranjan
mesh_terms: D024506:5' Flanking Region; D001426:Bacterial Proteins / Q000235:genetics; D001665:Binding Sites; D016680:Genome, Bacterial; D020407:Internet; D009169:Mycobacterium tuberculosis / Q000235:genetics; D009876:Operon; D011387:Prokaryotic Cells / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D018085:Regulon; D016415:Sequence Alignment; D012697:Serine Endopeptidases / Q000235:genetics; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*; D000099160:LexA Repressor Protein
chemical_list: D001426:Bacterial Proteins; D012697:Serine Endopeptidases; D014157:Transcription Factors; D000099160:LexA Repressor Protein