[Biological markers of osteoarthritis: data from the ECHODIAH cohort].
CORRELATIONS OF BIOLOGICAL MARKERS: Ten biological markers collected from blood or urine were analysed in the ECHODIAH cohort (patients with hip OA with a 3 Years follow up). In multivariate analysis, after adjustment for age, gender, and body mass index, some markers were found to be significantly correlated with clinical and radiological parameters. C-telopeptide of type II collagen (CTX-II) was correlated with pain, functional impairment, joint space narrowing, and subchondral sclerosis. C-reactive protein was correlated with pain. N-propeptide of type I collagen (PINP) was correlated with functional impairment, and cartilage oligomeric matrix protein (COMP) was correlated with inflammation. PREDICTIVE VALUE OF BIOLOGICAL MARKERS: High levels of urinary C-telopeptide of type II collagen (uCTX-II), a marker of cartilage degradation, and serum hyaluronic acid (sAH), a marker of synovial inflammation, were associated with higher risk of structure degeneration in osteoarthritis patients. Combined assay of these two markers could help identify patients with a higher risk of radiological progression, but many questions remain to be resolved.
Solignac
Marie
M
D000203:Activities of Daily Living; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism; D064236:Cartilage Oligomeric Matrix Protein; D003094:Collagen / Q000032:analysis / Q000378:metabolism; D024042:Collagen Type I; D003430:Cross-Sectional Studies; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000032:analysis / Q000378:metabolism; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis / Q000378:metabolism; D007249:Inflammation; D064235:Matrilin Proteins; D015999:Multivariate Analysis; D010003:Osteoarthritis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D010146:Pain / Q000209:etiology; D010446:Peptide Fragments / Q000032:analysis / Q000378:metabolism; D010455:Peptides / Q000032:analysis / Q000378:metabolism; D011237:Predictive Value of Tests; D011347:Procollagen / Q000032:analysis / Q000378:metabolism; D011379:Prognosis; D012307:Risk Factors; D013582:Synovial Fluid / Q000737:chemistry
D015415:Biomarkers; D064236:Cartilage Oligomeric Matrix Protein; D024042:Collagen Type I; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D064235:Matrilin Proteins; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C577553:TSP5 protein, human; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide; D006820:Hyaluronic Acid; D003094:Collagen; D002097:C-Reactive Protein