An investigation of an autonomic innervation of the vertebral artery using monoamine histofluorescence.
Blood flow to the hindbrain, via the paired vertebral arteries, must be uncompromised for adequate neurological functioning of its vital centres. Therefore, it would seem unlikely that the intracranial vertebral artery would need to vasoconstrict, thus reducing its blood flow. In order to investigate the existence and location of a noradrenaline-mediated constrictor mechanism in the wall of the intracranial vertebral artery, transverse sections of ten baboon and ten monkey vessels were stained with sucrose-potassium phosphate-glyoxylic acid (counterstained with malachite-green). This method allows the visualisation of catecholaminergic nerves when the sections are exposed to ultraviolet light. In this study of primate vascular tissue, however, none of the monkey or baboon vertebral artery sections showed the presence of noradrenergic nerves in the tunica media - tunica adventitia junction or penetrating the tunica media of the arteries. These findings indicate that the intracranial vertebral artery does not have a neurogenic vasomotor function in primates.
Mitchell
J A
JA
Department of Zoology & Physiology, University of Wyoming, Laramie, Wyoming 82071-3166, USA. mitchja@uwyo.edu
D000313:Adrenal Medulla / Q000166:cytology / Q000378:metabolism; D000818:Animals; D017776:Autonomic Pathways / Q000166:cytology* / Q000378:metabolism; D015306:Biogenic Monoamines / Q000096:biosynthesis*; D002522:Chlorocebus aethiops; D005260:Female; D006651:Histocytochemistry; D066298:In Vitro Techniques; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000378:metabolism; D008856:Microscopy, Fluorescence / Q000379:methods; D010215:Papio; D010865:Pilot Projects; D017540:Tunica Media / Q000166:cytology / Q000294:innervation / Q000378:metabolism; D014711:Vertebral Artery / Q000166:cytology* / Q000294:innervation / Q000378:metabolism
D015306:Biogenic Monoamines