title: [Minimal changes nephrotic syndrome associated to penicillamine treatment].
abstract: We describe three patients with minimal change nephrotic syndrome associated with penicillamine treatment. Two patients had systemic sclerosis and one had rheumatoid arthritis. Cumulative dose of D-penicillamine was similar in all cases, and nephrotic syndrome appeared after 15-33 months of treatment. The drug was stopped and nephrotic syndrome disappeared in 2-4 months, suggesting a possible causal relationship between penicillamine and minimal change disease.
authors.affiliation: Sección de Nefrología, Hospital Universitario de Guadalajara, Departamento de Medicina, Universidad de Alcalá.
authors.forename: M A
authors.initials: MA
authors.lastname: Basterrechea
authors.forename: G
authors.initials: G
authors.lastname: de Arriba
authors.forename: F
authors.initials: F
authors.lastname: García-Martín
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Heras
authors.forename: E
authors.initials: E
authors.lastname: Giménez-Vega
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D012595:Scleroderma, Systemic / Q000150:complications / Q000188:drug therapy
chemical_list: D007166:Immunosuppressive Agents; D010396:Penicillamine