Prognostic value of soluble P-selectin levels in colorectal cancer.
Measurement of soluble (s) P-selectin levels has been proposed as a diagnostic tool for monitoring the clinical course of human neoplasms. Thus, our study was aimed at analyzing the role of sP-selectin in association with clinicopathological variables in 181 patients with primary (n =149) or metastatic (n = 32) colorectal cancer (CRC), 34 patients with benign diseases and 181 control subjects. The results obtained showed that sP-selectin levels were higher in patients with CRC compared either to patients with benign disease (p = 0.006) or controls (p = 0.003). No differences were observed between the latter and patients with benign diseases. Increased median sP-selectin levels were significantly associated with the presence of distant metastasis (68.2 ng/ml vs. 48.6 ng/ml, p = 0.002). Of interest, carcinoembryonic antigen (CEA) levels were independently associated to sP-selectin (regression coefficient = 0.28, p < 0.002). Cox's proportional hazards survival analysis of primary CRC patients demonstrated that beside the stage of disease sP-selectin levels had an independent prognostic role in predicting recurrent disease (HR = 2.22, p = 0.019) and mortality from CRC (HR = 3.44, p= 0.017). These results suggest that measurement of plasma sP-selectin might represent a prognostic indicator in the management of patients with CRC.
Ferroni
Patrizia
P
Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy. patrizia.ferroni@uniromal.it
Roselli
Mario
M
Martini
Francesca
F
D'Alessandro
Roberta
R
Mariotti
Sabrina
S
Basili
Stefania
S
Spila
Antonella
A
Aloe
Simona
S
Palmirotta
Raffaele
R
Maggini
Alda
A
Del Monte
Girolamo
G
Mancini
Raffaello
R
Graziano
Franco
F
Cosimelli
Maurizio
M
Guadagni
Fiorella
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000556:secondary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D019007:P-Selectin / Q000097:blood*; D011379:Prognosis; D012016:Reference Values
D014408:Biomarkers, Tumor; D019007:P-Selectin