title: Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City.
abstract: Nineteen isolates of carbapenem-resistant Klebsiella species were recovered from 7 hospitals in New York City. Most K. pneumoniae belonged to a single ribotype. Nucleotide sequencing identified KPC-2, a carbapenem-hydrolyzing beta -lactamase. In 3 strains, TEM-30, an inhibitor-resistant beta -lactamase, was detected. Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States.
authors.affiliation: Wyeth Research, Pearl River, NY, USA.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Bradford
authors.forename: Simona
authors.initials: S
authors.lastname: Bratu
authors.forename: Carl
authors.initials: C
authors.lastname: Urban
authors.forename: Melissa
authors.initials: M
authors.lastname: Visalli
authors.forename: Noriel
authors.initials: N
authors.lastname: Mariano
authors.forename: David
authors.initials: D
authors.lastname: Landman
authors.forename: James J
authors.initials: JJ
authors.lastname: Rahal
authors.forename: Steven
authors.initials: S
authors.lastname: Brooks
authors.forename: Sanda
authors.initials: S
authors.lastname: Cebular
authors.forename: John
authors.initials: J
authors.lastname: Quale
mesh_terms: D015780:Carbapenems / Q000378:metabolism / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D009519:New York City; D018440:beta-Lactam Resistance / Q000502:physiology*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D015780:Carbapenems; C104731:beta-lactamase IRT-2; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases