title: [Significance of parameters of automated reticulocyte analysis in diagnosis and evaluation of treatment outcome in B12-deficient anemia].
abstract: The results of examinations of reticulocytes in blood samples of 12 patients with the confirmed diagnosis of B12-deficit anemia and of 20 virtually healthy subjects (control group) by means of the GEN-S hematological analyzer (Beckman-Coulter) are described in the paper. Typical changes of the reticulocyte parameters are defined and their dynamics (with treatment by Vitamin B12) is studied. It was established that the additional parameters of the reticulocyte analysis, characterizing the quantity of immature reticulocytes and the fraction of immature reticulocytes, increase by 3 days before the total quantity of erythrocytes increases, which means that the above parameters can be used earlier as criteria in evaluating the treatment efficiency.
authors.forename: G I
authors.initials: GI
authors.lastname: Nazarenko
authors.forename: S M
authors.initials: SM
authors.lastname: Kolenkin
authors.forename: S A
authors.initials: SA
authors.lastname: Lugovskaia
authors.forename: V P
authors.initials: VP
authors.lastname: Mikolauskas
mesh_terms: D000328:Adult; D000749:Anemia, Megaloblastic / Q000097:blood* / Q000188:drug therapy; D001322:Autoanalysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D017701:Reticulocyte Count; D012156:Reticulocytes / Q000473:pathology*; D014805:Vitamin B 12 / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000097:blood* / Q000188:drug therapy
chemical_list: D014805:Vitamin B 12