Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: a putative diagnostic role in resistant ovary syndrome?
OBJECTIVE
To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig-FSHR) in patients with premature ovarian failure (POF).


METHODS
Non-randomized study. Blood sampling for determination of circulating immunoglobulins. patients Two hundred and forty-seven patients with POF and 60 normally menstruating women (controls). measurements Circulating immunoglobulins that inhibit FSH binding to its receptor were assessed by FSH-binding inhibition assay.


RESULTS
Twenty-three out of 247 women with POF presented circulating immunoglobulins that inhibit FSH binding to its receptor. These patients had been previously diagnosed as ROS. Sixty control subjects proved negative.


CONCLUSIONS
Determination of the presence of circulating immunoglobulins that inhibit FSH binding to its receptor could be instrumental in diagnosing the gonadotropin resistance ovary syndrome.
Chiauzzi
Violeta A
VA
Instituto de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina. chiauzzi@dna.uba.ar
Bussmann
Leonardo
L
Calvo
Juan Carlos
JC
Sundblad
Victoria
V
Charreau
Eduardo H
EH
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005640:Follicle Stimulating Hormone / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis* / Q000276:immunology; D011962:Receptors, FSH / Q000378:metabolism
D015415:Biomarkers; D007136:Immunoglobulins; D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone