Virilization of young children after topical androgen use by their parents.
Children were virilized by contact with adults using cutaneous steroid preparations. Parents were unaware of the dangers of passive transfer. Laboratory data were consistent with exogenous androgen exposure. Each child had opportunity for passive exposure, and discontinuation of contact resulted in a decrease of androgen levels or regression of symptoms.
Kunz
Gregory J
GJ
Department of Pediatrics, Division of Pediatric Endocrinology, University of California, San Diego, California, USA. gjkunz@cox.net
Klein
Karen O
KO
Clemons
Robert D
RD
Gottschalk
Michael E
ME
Jones
Kenneth Lee
KL
D000279:Administration, Cutaneous; D015114:Androstenediol / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D010290:Parents; D011629:Puberty, Precocious / Q000139:chemically induced*; D013739:Testosterone / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D014770:Virilism / Q000139:chemically induced*
D006062:Gonadotropins; D013739:Testosterone; D015114:Androstenediol