Solution-phase reductive cyclization of 2-quinoxalinol analogs: systematic study of parallel synthesis.
1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.
Wu
Xiang-Hong
XH
Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China.
Liu
Gang
G
Zhang
Jing
J
Wang
Zhan-Guo
ZG
Xu
Song
S
Zhang
Suo-De
SD
Zhang
Liang
L
Wang
Lin
L
D001671:Biochemistry / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D011810:Quinoxalines / Q000138:chemical synthesis*; D012996:Solutions
D011810:Quinoxalines; D012996:Solutions