Mutations affecting retina development in Medaka.
In a large scale mutagenesis screen of Medaka we identified 60 recessive zygotic mutations that affect retina development. Based on the onset and type of phenotypic abnormalities, the mutants were grouped into five categories: the first includes 11 mutants that are affected in neural plate and optic vesicle formation. The second group comprises 15 mutants that are impaired in optic vesicle growth. The third group includes 18 mutants that are affected in optic cup development. The fourth group contains 13 mutants with defects in retinal differentiation. 12 of these have smaller eyes, whereas one mutation results in enlarged eyes. The fifth group consists of three mutants with defects in retinal pigmentation. The collection of mutants will be used to address the molecular genetic mechanisms underlying vertebrate eye formation.
Loosli
Felix
F
European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Del Bene
Filippo
F
Quiring
Rebecca
R
Rembold
Martina
M
Martinez-Morales
Juan-Ramon
JR
Carl
Matthias
M
Grabher
Clemens
C
Iquel
Caroline
C
Krone
Annette
A
Wittbrodt
Beate
B
Winkler
Sylke
S
Sasado
Takao
T
Morinaga
Chikako
C
Suwa
Hiroshi
H
Niwa
Katsutoshi
K
Henrich
Thorsten
T
Deguchi
Tomonori
T
Hirose
Yukihiro
Y
Iwanami
Norimasa
N
Kunimatsu
Sanae
S
Osakada
Masakazu
M
Watanabe
Tomomi
T
Yasuoka
Akihito
A
Yoda
Hiroki
H
Winkler
Christoph
C
Elmasri
Harun
H
Kondoh
Hisato
H
Furutani-Seiki
Makoto
M
Wittbrodt
Joachim
J
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D005808:Genes, Recessive; D009990:Oryzias / Q000196:embryology* / Q000235:genetics*; D010858:Pigmentation / Q000235:genetics; D012160:Retina / Q000166:cytology / Q000196:embryology*