title: Contribution of exotoxin A of Pseudomonas aeruginosa in acute and chronic experimental renal infection.
abstract: The role of Pseudomonas aeruginosa exotoxin A was studied in acute and chronic pyelonephritis models employing an exotoxin A-producing strain PAO, and its toxin deficient mutant PAOT1. Interestingly, the mutant strain was found to be at an advantage in its ability to induce acute pyelonephritis and it induced severer renal pathology. No significant differences were observed in the ability of the parent strain and its mutant to induce chronic renal inflammation.
authors.affiliation: Department of Microbiology, Panjab University, Chandigarh, India.
authors.forename: Saroj
authors.initials: S
authors.lastname: Sharma
authors.forename: Ramanjeet
authors.initials: R
authors.lastname: Kaur
authors.forename: Vanashree
authors.initials: V
authors.lastname: Yadav
authors.forename: Kusum
authors.initials: K
authors.lastname: Harjai
authors.forename: Kusum
authors.initials: K
authors.lastname: Joshi
mesh_terms: D036002:ADP Ribose Transferases; D000208:Acute Disease; D000818:Animals; D001427:Bacterial Toxins; D002908:Chronic Disease; D004195:Disease Models, Animal; D005098:Exotoxins; D006801:Humans; D007668:Kidney / Q000382:microbiology / Q000473:pathology; D051379:Mice; D009154:Mutation; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity*; D011704:Pyelonephritis / Q000382:microbiology*; D014774:Virulence; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
chemical_list: D036002:ADP Ribose Transferases; D001427:Bacterial Toxins; D005098:Exotoxins; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A