title: Hepatic ethoxyresorufin O-deethylase (EROD) activity in flounder (Platichthys flesus) from contaminant impacted estuaries of the United Kingdom: continued monitoring 1999-2001.
abstract: The determination of hepatic ethoxyresorufin O-deethylase (EROD) has been used to assess the induction of the mixed function oxygenase system (MFO) of flounder (Platichthys flesus) in UK estuaries. Induction of the MFO system denotes possible exposure to certain organic contaminants (e.g. polycyclic aromatic hydrocarbons, polychlorinated biphenyls) and its measure has been incorporated in national monitoring programmes. This study presents EROD monitoring data from 5 UK estuaries taken between 1999 and 2001 and builds on data from previous years. The results reveal that for all sampled estuaries EROD values have been significantly (p < 0.05) elevated on the majority of occasions in comparison with the reference estuary, the Alde in Suffolk, UK. However, the limited temporal scale of the reported monitoring does not allow any conclusions to be drawn with respect to trends in the data. Possible factors influencing the data (size, gender, seasonality, reproductive status, etc.) are discussed and recommendations for continued monitoring are made.
authors.affiliation: CEFAS Burnham Laboratory, Remembrance Avenue, Burnham-on-Crouch, Essex CM0 8HA, UK. m.f.kirby@cefas.co.uk
authors.forename: M F
authors.initials: MF
authors.lastname: Kirby
authors.forename: P
authors.initials: P
authors.lastname: Neall
authors.forename: T A
authors.initials: TA
authors.lastname: Bateman
authors.forename: J E
authors.initials: JE
authors.lastname: Thain
mesh_terms: D000818:Animals; D019363:Cytochrome P-450 CYP1A1 / Q000494:pharmacology*; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000506:poisoning*; D005432:Flounder / Q000502:physiology*; D008099:Liver / Q000201:enzymology; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D011084:Polycyclic Aromatic Hydrocarbons / Q000506:poisoning*; D012016:Reference Values; D006113:United Kingdom; D014874:Water Pollutants, Chemical / Q000506:poisoning*
chemical_list: D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1