[Dynamic monitoring of sIL-2R, IL-2 and IL-6 levels of serum after double-hand transplantation].
OBJECTIVE
To investigate the value of monitoring cytokines in serum after human double-hand allotransplantation.


METHODS
We detected solube interleukin-2 receptor(sIL-2R), interleukin-2(IL-2) and interleukin-6(IL-6) levels of the serum in the patient who were performed double-hand transplantation with immunosuppressive from September 2000 to November 2000, and in 15 healthy volunteers by using enzyme linked immunosorbent assays.


RESULTS
The IL-2 and IL-6 levels decreased quickly during inducing period (P < 0.05), and then increased gradually. While the sIL-2R level increased. The IL-2 level was lower(P < 0.05), the IL-6 and sIL-2R levels were slightly higher when compared with those before transplantation. There was significant difference in the IL-2 level between the patient and healthy volunteers both before and after transplantation, in the IL-6 level between the patient and healthy volunteers during inducing period.


CONCLUSIONS
IL-2, IL-6 and sIL-2R levels of serum may be useful in diagnosis of rejection, prevention of opportunistic infection, tumor and graft versus host disease.
Xiang
Dayong
D
Department of Orthopaedics and Traumatology, Nanfang Hospital, First Military Medical University, Guangzhou, Guangdong, 510515, P. R. China.
Pei
Guoxian
G
Qiu
Yurong
Y
D000328:Adult; D000673:Amputation, Traumatic / Q000601:surgery; D016207:Cytokines / Q000097:blood*; D005260:Female; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000517:prevention & control; D006230:Hand Injuries / Q000097:blood* / Q000601:surgery; D063987:Hand Transplantation; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D013997:Time Factors; D014184:Transplantation, Homologous
D016207:Cytokines; D007376:Interleukin-2; D015850:Interleukin-6; D015375:Receptors, Interleukin-2