title: Effects of high-dose RU-486 treatment on climacteric complaints in hysterectomized postmenopausal women: a 6-week pilot study.
abstract: We investigated the effect of the anti-progestogen mifepristone (RU-486) on climacteric complaints. Four hysterectomized postmenopausal women, with at least 35 hot flushes per week, were treated with daily 200mg RU-486 for 6 weeks. RU-486 did not significantly improve climacteric complaints. Although this result does not support further clinical research with this dose of RU-486 for the treatment of climacteric complaints, potential effects of higher, but more interestingly of lower, dosages of RU-486 cannot be excluded.
authors.forename: Marieke O
authors.initials: MO
authors.lastname: Verhoeven
authors.forename: Marius J
authors.initials: MJ
authors.lastname: van der Mooren
authors.forename: Herjan J T
authors.initials: HJ
authors.lastname: Coelingh Bennink
authors.forename: René F
authors.initials: RF
authors.lastname: van der Linden
mesh_terms: D002979:Climacteric / Q000187:drug effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015735:Mifepristone / Q000008:administration & dosage*; D010865:Pilot Projects; D017698:Postmenopause
chemical_list: D015735:Mifepristone