[Significance of kallikrein, angiotensin-converting enzyme, and proteolysis inhibitors in vascular complications in diabetes mellitus type 1 in children].
Searching for markers triggering the vascular complications in diabetes mellitus, type 1, is a topical issue of modern endocrinology. The study focuses on the parameters of the kallikrein-kinin, rennin-angiotensin systems and on proteolysis inhibitors involved in hemodynamics regulation. It was established that, at earlier diabetes stages, which are characterized by polyuria, the activity of blood-plasma kallikrein is increasing, while, at the disease later stages and in the process of nephropathy progression, there is an increasing activity of the angiotensin-converting enzyme accompanied by an essential suppression of the alpha 1-proteinase inhibitor.
Sukhanova
G A
GA
Kondrat'eva
E I
EI
Spirina
L V
LV
D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology; D003930:Diabetic Retinopathy / Q000097:blood / Q000209:etiology; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D012083:Renin / Q000097:blood*; D015842:Serine Proteinase Inhibitors / Q000097:blood*; D014652:Vascular Diseases / Q000097:blood* / Q000209:etiology; D000515:alpha 1-Antitrypsin / Q000032:analysis*; D000511:alpha-Macroglobulins / Q000032:analysis
D015842:Serine Proteinase Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D007610:Kallikreins; D012083:Renin