title: Genome evolution in yeasts.
abstract: Identifying the mechanisms of eukaryotic genome evolution by comparative genomics is often complicated by the multiplicity of events that have taken place throughout the history of individual lineages, leaving only distorted and superimposed traces in the genome of each living organism. The hemiascomycete yeasts, with their compact genomes, similar lifestyle and distinct sexual and physiological properties, provide a unique opportunity to explore such mechanisms. We present here the complete, assembled genome sequences of four yeast species, selected to represent a broad evolutionary range within a single eukaryotic phylum, that after analysis proved to be molecularly as diverse as the entire phylum of chordates. A total of approximately 24,200 novel genes were identified, the translation products of which were classified together with Saccharomyces cerevisiae proteins into about 4,700 families, forming the basis for interspecific comparisons. Analysis of chromosome maps and genome redundancies reveal that the different yeast lineages have evolved through a marked interplay between several distinct molecular mechanisms, including tandem gene repeat formation, segmental duplication, a massive genome duplication and extensive gene loss.
authors.affiliation: Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie. bdujon@pasteur.fr
authors.forename: Bernard
authors.initials: B
authors.lastname: Dujon
authors.forename: David
authors.initials: D
authors.lastname: Sherman
authors.forename: Gilles
authors.initials: G
authors.lastname: Fischer
authors.forename: Pascal
authors.initials: P
authors.lastname: Durrens
authors.forename: Serge
authors.initials: S
authors.lastname: Casaregola
authors.forename: Ingrid
authors.initials: I
authors.lastname: Lafontaine
authors.forename: Jacky
authors.initials: J
authors.lastname: De Montigny
authors.forename: Christian
authors.initials: C
authors.lastname: Marck
authors.forename: Cécile
authors.initials: C
authors.lastname: Neuvéglise
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Talla
authors.forename: Nicolas
authors.initials: N
authors.lastname: Goffard
authors.forename: Lionel
authors.initials: L
authors.lastname: Frangeul
authors.forename: Michel
authors.initials: M
authors.lastname: Aigle
authors.forename: Véronique
authors.initials: V
authors.lastname: Anthouard
authors.forename: Anna
authors.initials: A
authors.lastname: Babour
authors.forename: Valérie
authors.initials: V
authors.lastname: Barbe
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Barnay
authors.forename: Sylvie
authors.initials: S
authors.lastname: Blanchin
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Beckerich
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Beyne
authors.forename: Claudine
authors.initials: C
authors.lastname: Bleykasten
authors.forename: Anita
authors.initials: A
authors.lastname: Boisramé
authors.forename: Jeanne
authors.initials: J
authors.lastname: Boyer
authors.forename: Laurence
authors.initials: L
authors.lastname: Cattolico
authors.forename: Fabrice
authors.initials: F
authors.lastname: Confanioleri
authors.forename: Antoine
authors.initials: A
authors.lastname: De Daruvar
authors.forename: Laurence
authors.initials: L
authors.lastname: Despons
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Fabre
authors.forename: Cécile
authors.initials: C
authors.lastname: Fairhead
authors.forename: Hélène
authors.initials: H
authors.lastname: Ferry-Dumazet
authors.forename: Alexis
authors.initials: A
authors.lastname: Groppi
authors.forename: Florence
authors.initials: F
authors.lastname: Hantraye
authors.forename: Christophe
authors.initials: C
authors.lastname: Hennequin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Jauniaux
authors.forename: Philippe
authors.initials: P
authors.lastname: Joyet
authors.forename: Rym
authors.initials: R
authors.lastname: Kachouri
authors.forename: Alix
authors.initials: A
authors.lastname: Kerrest
authors.forename: Romain
authors.initials: R
authors.lastname: Koszul
authors.forename: Marc
authors.initials: M
authors.lastname: Lemaire
authors.forename: Isabelle
authors.initials: I
authors.lastname: Lesur
authors.forename: Laurence
authors.initials: L
authors.lastname: Ma
authors.forename: Héloïse
authors.initials: H
authors.lastname: Muller
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Nicaud
authors.forename: Macha
authors.initials: M
authors.lastname: Nikolski
authors.forename: Sophie
authors.initials: S
authors.lastname: Oztas
authors.forename: Odile
authors.initials: O
authors.lastname: Ozier-Kalogeropoulos
authors.forename: Stefan
authors.initials: S
authors.lastname: Pellenz
authors.forename: Serge
authors.initials: S
authors.lastname: Potier
authors.forename: Guy-Franck
authors.initials: GF
authors.lastname: Richard
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Straub
authors.forename: Audrey
authors.initials: A
authors.lastname: Suleau
authors.forename: Dominique
authors.initials: D
authors.lastname: Swennen
authors.forename: Fredj
authors.initials: F
authors.lastname: Tekaia
authors.forename: Micheline
authors.initials: M
authors.lastname: Wésolowski-Louvel
authors.forename: Eric
authors.initials: E
authors.lastname: Westhof
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Wirth
authors.forename: Maria
authors.initials: M
authors.lastname: Zeniou-Meyer
authors.forename: Ivan
authors.initials: I
authors.lastname: Zivanovic
authors.forename: Monique
authors.initials: M
authors.lastname: Bolotin-Fukuhara
authors.forename: Agnès
authors.initials: A
authors.lastname: Thierry
authors.forename: Christiane
authors.initials: C
authors.lastname: Bouchier
authors.forename: Bernard
authors.initials: B
authors.lastname: Caudron
authors.forename: Claude
authors.initials: C
authors.lastname: Scarpelli
authors.forename: Claude
authors.initials: C
authors.lastname: Gaillardin
authors.forename: Jean
authors.initials: J
authors.lastname: Weissenbach
authors.forename: Patrick
authors.initials: P
authors.lastname: Wincker
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Souciet
mesh_terms: D015825:Chromosomes, Fungal / Q000235:genetics; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D020440:Gene Duplication; D005800:Genes, Fungal / Q000235:genetics*; D016681:Genome, Fungal; D008969:Molecular Sequence Data; D012335:RNA, Ribosomal / Q000235:genetics; D012343:RNA, Transfer / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics; D026801:Synteny / Q000235:genetics; D020080:Tandem Repeat Sequences / Q000235:genetics; D015003:Yeasts / Q000145:classification* / Q000235:genetics*
chemical_list: D012335:RNA, Ribosomal; D029701:Saccharomyces cerevisiae Proteins; D012343:RNA, Transfer