title: Epidural analgesia in abdominal surgery: 0.2% ropivacaine with sufentanil.
abstract: OBJECTIVE
  Combining an opioid with peridural local analgesia is an excellent technique to control post-operative pain. Sufentanil is a widely used opioid agent, but its optimal dosage has not yet been defined. In this study we wanted to determine the best dose of epidural sufentanil in major surgery.
  
  
  METHODS
  Before the operation, 45 major abdominal surgery patients received blended anesthesia through an epidural chest catheter. The patients were randomized into 3 groups of 15 subjects according to different sufentanil doses [0.2% ropivacaine combined with sufentanil at a dose of 0.5 microg/ml(-1), 0.75 microg/ml(-1), or 1 microg/ml(-1) (groups A, B and C, respectively)] administered through an epidural chest catheter connected to an elastometric pump (5 ml/h) for the first 36 postoperative hours. The level of postoperative analgesia in motion and at rest was measured using an analog visual scale (VAS-R, VAS-I).
  
  
  RESULTS
  Analgesia was best in group A, and similar in groups B and C; 2 cases of pruritus were noted in group C. The VAS-I scores were <3 across all 3 patient groups.
  
  
  CONCLUSIONS
  Epidural analgesia is an efficacious and reliable technique. The combination of 0.2% ropivacaine and 0.75 microg/ml(-1) sufentanil was found to be the optimum choice between analgesic efficacy and minor side effects, which correlated with the higher dose of sufentanil given to group C.
authors.affiliation: Department of Anesthesiology and Critical Care, Catholic University of Rome, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Cosmo
authors.forename: P
authors.initials: P
authors.lastname: Primieri
authors.forename: E
authors.initials: E
authors.lastname: Adducci
authors.forename: M
authors.initials: M
authors.lastname: Fiorenti
authors.forename: G
authors.initials: G
authors.lastname: Beccia
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D015360:Analgesia, Epidural; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077212:Ropivacaine; D017409:Sufentanil / Q000008:administration & dosage*
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000077212:Ropivacaine; D017409:Sufentanil