title: Molecular characterisation of SENV and TTV infections in hepatopathic liver-transplant patients. Brief Report.
abstract: The presence of SENV and TTV infections among 50 patients who had undergone liver transplantation was evaluated. UTR amplification showed that 46 (92%) sera were positive. ORF-1 amplification showed that 25 (50%) patients were positive for either SENV (51.3%), TTV (10.8%), or both (37.8%) all confirmed by sequencing and phylogenetic analysis. SENV-D and SENV-H were the most prevalent viruses. The phylogenetic analysis of isolates showed that whereas SENV-D and SENV-G viruses showed sequence stability and strain persistence, SENV-H had cleared or mutated. Biological differences seem to exist among different genotypes in terms of viral replication and their persistence.
authors.affiliation: Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Genovese
authors.forename: S
authors.initials: S
authors.lastname: Dettori
authors.forename: C
authors.initials: C
authors.lastname: Argentini
authors.forename: L A
authors.initials: LA
authors.lastname: Kondili
authors.forename: V
authors.initials: V
authors.lastname: La Sorsa
authors.forename: G
authors.initials: G
authors.lastname: Tisone
authors.forename: M
authors.initials: M
authors.lastname: Angelico
authors.forename: M
authors.initials: M
authors.lastname: Rapicetta
mesh_terms: D020121:5' Untranslated Regions; D018136:Circoviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D018173:Circoviridae Infections / Q000821:virology*; D004279:DNA, Viral / Q000097:blood / Q000737:chemistry; D005260:Female; D005814:Genes, Viral; D005838:Genotype; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D016366:Open Reading Frames; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D022783:Torque teno virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification
chemical_list: D020121:5' Untranslated Regions; D004279:DNA, Viral