Comparison of methylprednisolone with dexamethasone in treatment of acute spinal injury in rats.
Effect of methylprednisolone sodium succinate (MPSS) and its comparison with dexamethasone in experimentally induced acute spinal cord compression in adult rats was studied. The rats were divided into group A (control) and group B, which was subdivided into B1, B2, B3 where MPSS was given after 1, 8 and 24 hr and B4 where dexamethasone was given after 1 hr of cord injury respectively. Proper neurological evaluation was done with mobility, running and climbing score. Recovery index was evaluated for 7 days. After sacrificing the rats, spinal cord was observed histopathologically. Mean recovery index and microscopic findings based on hemorrhage in gray and white matter, neuronal degeneration, hematomyelia and edema in white matter were recorded. The results suggested that MPSS was effective in promoting post-traumatic clinical and histological recovery and to a greater extent, when given 1 hr after trauma. MPSS is more effective than dexamethasone in reducing edema when both are given after interval of 1 hr.
Sharma
Alok
A
Department of Neurosurgery, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai 400 022, India. alok276@hotmail.com
Tiwari
Rajan
R
Badhe
Prerna
P
Sharma
Garima
G
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology; D000860:Hypoxia; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects; D013117:Spinal Cord Compression / Q000188:drug therapy*; D013119:Spinal Cord Injuries / Q000188:drug therapy*; D013997:Time Factors
D005938:Glucocorticoids; D018696:Neuroprotective Agents; D008776:Methylprednisolone Hemisuccinate; D003907:Dexamethasone