Cortical mapping of auditory-evoked offset responses in rats.
We characterized the auditory-evoked offset responses of the rat auditory cortex by multiple-site surface microelectrode recording. Tone bursts served as test stimuli. Offset responses did not appear tonotopically, but at the fringe of tonotopic onset distributions. Offset amplitude was significantly sensitive to sound intensity, fall time at tone termination, and duration. These results suggest that offset responses are associated with inhibitory responses surrounding excitatory onset responses, and offset responses become large when inhibition becomes strong and long or terminates synchronously. Thus, the rebound after the inhibition in the presence of a stimulus is likely to be a major cause of offset responses in the auditory cortex.
Takahashi
Hirokazu
H
Department of Engineering Synthesis, Graduate School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan. hiro@hnl.t.u-tokyo.ac.jp
Nakao
Masayuki
M
Kaga
Kimitaka
K
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology / Q000528:radiation effects; D001931:Brain Mapping; D004307:Dose-Response Relationship, Radiation; D004566:Electrodes; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology* / Q000528:radiation effects; D009433:Neural Inhibition / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors