title: No association between DUP25 and anxiety disorders.
abstract: Gratacos et al. [2001: Cell 106:367-379] described an interstitial duplication dup(15)q24q26 (DUP25) in patients with anxiety disorders; this duplication was found in approximately 90% of patients and in 7% of controls. In order to determine if DUP25 is present in additional individuals susceptible to panic attacks, we tested 44 patients with anxiety disorders, using probes 251c23 and 216c14 mapping in the 15q24 and 15q26 region. We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here.
authors.affiliation: Division de Génétique Médicale, Hôpitaux Universitaires de Genève, 1 rue Michel Servet 1211, Geneva 4, Switzerland.
authors.forename: Charlotte Neergaard
authors.initials: CN
authors.lastname: Henrichsen
authors.forename: Richard
authors.initials: R
authors.lastname: Delorme
authors.forename: Maria
authors.initials: M
authors.lastname: Boucherie
authors.forename: Dominique
authors.initials: D
authors.lastname: Marelli
authors.forename: Patrick
authors.initials: P
authors.lastname: Baud
authors.forename: Franck
authors.initials: F
authors.lastname: Bellivier
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.forename: Nadia
authors.initials: N
authors.lastname: Chabane
authors.forename: Chantal
authors.initials: C
authors.lastname: Henry
authors.forename: Marion
authors.initials: M
authors.lastname: Leboyer
authors.forename: Alain
authors.initials: A
authors.lastname: Malafosse
authors.forename: Stylianos E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: Sophie
authors.initials: S
authors.lastname: Dahoun
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002884:Chromosomes, Human, Pair 15; D015342:DNA Probes; D005260:Female; D020440:Gene Duplication; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology
chemical_list: D015342:DNA Probes