Virgin olive oil normalizes the altered triacylglycerol molecular species composition of adipose tissue in spontaneously hypertensive rats.
The present study was conducted in order to evaluate the influence of hypertension on the triacylglycerol (TG) molecular species composition and other lipid classes of rat adipose tissue. In addition, the effect of two dietary oils, with a similar content in oleic acid but different TG moieties, was studied. Virgin olive oil (VOO) or high-oleic sunflower oil (HOSO) was added to a baseline diet (BD) and administrated to Wistar-Kyoto and spontaneously hypertensive rats (SHR) for 12 weeks. Both VOO and HOSO normalized the altered composition of TG molecular species and phospholipid (PL) fatty acids in SHR compared to animals fed BD, although the effect exhibited by VOO was greater. Rats fed HOSO showed a greater palmitic (p < 0.05) and lower linoleic acid (p < 0.05) incorporation into PL but a greater accumulation of linoleic acid-containing TG species, particularly dioleoyl-linoleoyl-glycerol, with a concomitant displacement of trilinolein. Both oils were capable of increasing the lipoprotein lipase (LPL) activity in normotensive rats, but only VOO did so in the SHR. Therefore, it was concluded that although oleic acid-rich diets improve some of the altered parameters of SHR adipose tissue, VOO is more effective than HOSO in this regard.
Perona
Javier S
JS
Instituto de la Grasa (CSIC), Avenida Padre García Tejero 4, 41012 Seville, Spain.
Ruiz-Gutierrez
Valentina
V
D000273:Adipose Tissue / Q000737:chemistry*; D000818:Animals; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000032:analysis; D006973:Hypertension / Q000378:metabolism*; D019787:Linoleic Acid / Q000032:analysis; D008071:Lipoprotein Lipase / Q000378:metabolism; D019301:Oleic Acid / Q000032:analysis; D000069463:Olive Oil; D019308:Palmitic Acid / Q000032:analysis; D010743:Phospholipids / Q000032:analysis; D010938:Plant Oils / Q000008:administration & dosage*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D000074242:Sunflower Oil; D014280:Triglycerides / Q000032:analysis*
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D000069463:Olive Oil; D010743:Phospholipids; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D019301:Oleic Acid; D019308:Palmitic Acid; D019787:Linoleic Acid; D008071:Lipoprotein Lipase