Iron and ageing: an introduction to iron regulatory mechanisms.
While there have been significant advances made in our understanding of the cellular and molecular mechanisms that regulate iron absorption, transport, storage, and utilization, the effect of ageing on these mechanisms and the role of iron in the ageing process is not fully understood. Thus, this review will provide an overview of the iron regulatory mechanisms that may be a factor in the ageing process. Additional reviews in this volume represent an attempt to explore the very latest information on the regulation of iron with a particular emphasis on age-related pathology including mitochondrial function, Parkinson's disease, Alzheimer's disease, stroke, and cardiovascular disease.
Levenson
Cathy W
CW
Program in Neuroscience and Department of Nutrition, Food and Exercise Sciences, 237 Biomedical Research Facility, Florida State University, Tallahassee, FL 32306-4340, USA. levenson@neuro.fsu.edu
Tassabehji
Nadine M
NM
D000375:Aging; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D001692:Biological Transport / Q000502:physiology; D001921:Brain / Q000378:metabolism; D027682:Cation Transport Proteins / Q000502:physiology; D002570:Ceruloplasmin / Q000502:physiology; D005293:Ferritins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D000071020:Hemochromatosis Protein; D064451:Hepcidins; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D007501:Iron / Q000378:metabolism* / Q000502:physiology; D033862:Iron-Binding Proteins / Q000502:physiology; D035925:Iron-Regulatory Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D020871:RNA Stability; D011990:Receptors, Transferrin / Q000235:genetics / Q000502:physiology; D014168:Transferrin / Q000502:physiology; D044763:Ubiquitin-Conjugating Enzymes / Q000502:physiology; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2
D023181:Antimicrobial Cationic Peptides; D027682:Cation Transport Proteins; D002570:Ceruloplasmin; D005293:Ferritins; D000071020:Hemochromatosis Protein; D064451:Hepcidins; D015395:Histocompatibility Antigens Class I; D007501:Iron; D033862:Iron-Binding Proteins; D035925:Iron-Regulatory Proteins; D008565:Membrane Proteins; D011990:Receptors, Transferrin; D014168:Transferrin; D044763:Ubiquitin-Conjugating Enzymes; D000098742:Ferroportin; D000099236:Solute Carrier Family 11, Member 2; C492164:HEPH protein, human; C103673:HFE protein, human; C097308:UBE2D1 protein, human