title: Effects of Chinese herbal medicinal ingredients on peripheral lymphocyte proliferation and serum antibody titer after vaccination in chicken.
abstract: The purpose of these experiments is to study the effects of Chinese herbal medicinal ingredients (CHMIs) on peripheral lymphocyte proliferation and serum antibody titer in chicken vaccinated with Newcastle disease. Nine CHMIs were chosen for the experiments. Astragalus polysaccharide (APS), Isatis root polysaccharide (IRPS), Epimedium flavone (EF), Propolis flavone (PF), Astragalosides (AS) and Ginsenosides (GS) could promote lymphocyte proliferation and antibody titer, while Epimedium polysaccharide (EPS) mainly stimulated cellular immune responses. Chinese angelica polysaccharide (CAPS) and Propolis polysaccharide (PPS) exerted weaker effects on promoting immune responses. APS, IRPS, PPS and PF in promoting lymphocyte proliferation, and IRPS, PPS, EF and PF in promoting humoral immunity in higher dose were significantly stronger than in lower dose. Our results indicated that almost all of the nine CHMIs could promote both humoral and cellular immune responses and would be expected as the component drug of a new-type immunopotentiator.
authors.affiliation: Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Jiangsu, PR China.
authors.forename: Xiangfeng
authors.initials: X
authors.lastname: Kong
authors.forename: Yuanliang
authors.initials: Y
authors.lastname: Hu
authors.forename: Rong
authors.initials: R
authors.lastname: Rui
authors.forename: Deyun
authors.initials: D
authors.lastname: Wang
authors.forename: Xiangrui
authors.initials: X
authors.lastname: Li
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000097:blood; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D047309:Flavones / Q000494:pharmacology; D036145:Ginsenosides / Q000494:pharmacology; D006386:Hemagglutination Tests; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D009521:Newcastle Disease / Q000276:immunology / Q000517:prevention & control*; D011134:Polysaccharides / Q000494:pharmacology; D011200:Poultry; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D004365:Drugs, Chinese Herbal; D047309:Flavones; D036145:Ginsenosides; C424862:Newcastle disease virus vaccine MTH-68-H; D011134:Polysaccharides; D014765:Viral Vaccines