title: Longitudinal analysis of perfusion lung scintigrams of patients with unoperated chronic thromboembolic pulmonary hypertension.
abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is the result of single or recurrent pulmonary thromboemboli that are thought to develop into organized pulmonary arterial obstructions by recurrent embolism and in situ thrombosis. Radioisotopic ventilation-perfusion scanning (V/Q scan) is a safe and highly sensitive test for pulmonary thromboembolic disease. The aim was to assess the natural history of thrombus expansion. We performed a prospective quantitative evaluation of ventilation/perfusion scintigrams (V/Q scans) in 20 patients with severe unoperated CTEPH. The baseline V/Q scan of each patient served as a reference for the second scan 21.7 +/- 8.2 months later. Planar images with intravenous 99mTc-labeled human albumin macroaggregates were reconstructed in six standard projections. Perfusion scans were analyzed by a semi-quantitative evaluation. In parallel, hemodynamics and clinical condition were prospectively observed. Lung perfusion scintigrams analyzed by a semi-quantitative method in patients with severe unoperated CTEPH show an apparent decrease of segmental flow abnormalities over time, paralleling right ventricular decline.
authors.affiliation: Department of Cardiology, Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria.
authors.forename: Nika
authors.initials: N
authors.lastname: Skoro-Sajer
authors.forename: Alexander
authors.initials: A
authors.lastname: Becherer
authors.forename: Walter
authors.initials: W
authors.lastname: Klepetko
authors.forename: Meinhard P
authors.initials: MP
authors.lastname: Kneussl
authors.forename: Gerald
authors.initials: G
authors.lastname: Maurer
authors.forename: Irene M
authors.initials: IM
authors.lastname: Lang
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000503:physiopathology; D008137:Longitudinal Studies; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation; D011655:Pulmonary Embolism / Q000150:complications* / Q000000981:diagnostic imaging* / Q000503:physiopathology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D014692:Ventilation-Perfusion Ratio
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin