title: Cost-effectiveness of endoscopic ultrasonography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography in patients suspected of pancreaticobiliary disease.
abstract: BACKGROUND
  It is not known whether initial endoscopic ultrasonography (EUS) or magnetic resonance cholangiopancreatography (MRCP) is more cost effective than endoscopic retrograde cholangiopancreatography (ERCP).
  
  
  METHODS
  A cost-effectiveness analysis of EUS, MRCP and ERCP was performed on 163 patients. The effectiveness of an investigation was defined as the percentage of patients with no need for further evaluation after the investigation in question had been performed. Costs were assumed from the budget-holder's point of view.
  
  
  RESULTS
  MRCP, EUS and ERCP had a total accuracy of 0.91, 0.93 and 0.92, respectively. Eighty-four (52%) patients needed endoscopic therapy in combination with ERCP, giving an effectiveness of MRCP, EUS, and ERCP of 0.44, 0.45 and 0.92, respectively. The cost-effectiveness of MRCP, EUS, and ERCP was 6622, 7353 and 4246 Danish Kroner (DKK) per fully investigated and treated patient (1 DKK=0.14 EUR).
  
  
  CONCLUSIONS
  Within a patient population with a probability of therapeutic ERCP in 50% of the patients, ERCP was the most cost-effective strategy.
authors.affiliation: Dept. of Surgery and Radiology, Vejle Hospital, Denmark. alan.ainsworth@dadlnet.dk
authors.forename: A P
authors.initials: AP
authors.lastname: Ainsworth
authors.forename: S R
authors.initials: SR
authors.lastname: Rafaelsen
authors.forename: P A
authors.initials: PA
authors.lastname: Wamberg
authors.forename: T
authors.initials: T
authors.lastname: Pless
authors.forename: J
authors.initials: J
authors.lastname: Durup
authors.forename: M B
authors.initials: MB
authors.lastname: Mortensen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001660:Biliary Tract Diseases / Q000175:diagnosis* / Q000191:economics / Q000628:therapy; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000191:economics*; D003362:Cost-Benefit Analysis; D019160:Endosonography / Q000191:economics*; D005260:Female; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008279:Magnetic Resonance Imaging / Q000191:economics*; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000175:diagnosis* / Q000191:economics / Q000628:therapy; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity