Effect of PPADS on P2X receptor-mediated responses of human blood vessels.
In vitro experiments showed that pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid almost completely suppressed contractile responses of the gallbladder artery to alpha,beta-methylene-ATP, while alpha,beta-methylene-ATP-induced contractions of the major subcutaneous vein of patients with varicose disease did not change under the effect of the antagonist. Pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid significantly reduced contractions of the major subcutaneous veins induced by alpha,beta-methylene-ATP (in two highest concentrations) in patients without varicosity. These results indicate different sensitivity of human blood vessels to the studied P2 receptor agonist and antagonist.
Ziganshin
A U
AU
Department of Pharmacology, Department of Surgical Diseases No. 2, Kazan State Medical University. airatz@auz.kcn.ru
Ziganshin
B A
BA
Giniyatova
L R
LR
Dzhordzhikiya
R K
RK
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D001161:Arteriosclerosis / Q000503:physiopathology; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology*; D005268:Femoral Vein / Q000187:drug effects / Q000502:physiology; D005704:Gallbladder / Q000098:blood supply; D006801:Humans; D066298:In Vitro Techniques; D016491:Peripheral Vascular Diseases / Q000503:physiopathology; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D018048:Receptors, Purinergic P2 / Q000187:drug effects* / Q000502:physiology*; D058469:Receptors, Purinergic P2X; D014648:Varicose Veins / Q000503:physiopathology; D014661:Vasoconstriction / Q000187:drug effects
D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; C077792:pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; D011732:Pyridoxal Phosphate; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate