title: Effects of midazolam on the threshold of lidocaine-induced seizures in the dog--comparison with diazepam.
abstract: The anticonvulsive effect of midazolam was compared with that of diazepam in ten dogs. Lidocaine-induced seizure waves on the electroencephalogram were used to observe the suppressive effect of the drugs. Midazolam, 0.2 mg.kg(-1), was found to possess a stronger suppressive effect against lidocaine-induced seizures than the same dose of diazepam. These two drugs showed to possess similar effects on cerebral and systemic circulations and cerebral metabolism during seizures.
authors.affiliation: Department of Anesthesia, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Horikawa
authors.forename: T
authors.initials: T
authors.lastname: Tada
authors.forename: M
authors.initials: M
authors.lastname: Sakai
authors.forename: T
authors.initials: T
authors.lastname: Karube
authors.forename: K
authors.initials: K
authors.lastname: Ichiyanagi