title: Cutaneous sporotrichosis with refractory and reinfectious lesions in a healthy female.
abstract: We report a 71-year-old Japanese healthy female with an unusual clinical course of sporotrichosis; she developed infectious lesions on the face and the left upper limb at different periods. The initial lesion appeared on her right cheek and nose in 1992. Histopathologic and fungal examinations comfirmed the diagnosis of sporotrichosis. She was treated with oral potassium iodide and/or itraconazole and topical heat therapy. She had three recurrences and her facial plaque, which was resistant to several conventional treatments, was eventually excised and then grafted in 1996. After the surgical procedure, oral medication was continued for two months. In 2001, new lesions appeared on her left hand and forearm, which were anatomically different from the former lesions. Based on histopathologic and mycological findings, we confirmed reinfection with sporotrichosis. She was again treated with potassium iodide. The cutaneous lesions completely resolved after 26 weeks without surgical treatment.
authors.affiliation: Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan.
authors.forename: Taro
authors.initials: T
authors.lastname: Shinogi
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Misago
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Narisawa
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D011193:Potassium Iodide / Q000627:therapeutic use; D012008:Recurrence; D012867:Skin / Q000473:pathology; D013174:Sporotrichosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000935:Antifungal Agents; D011193:Potassium Iodide; D017964:Itraconazole