Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus.
Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of autoimmune disease. A new pathway of disease pathogenesis opens new avenues of research with thousands of questions that remain to be answered. In this review I attempt to propose how the RUNX proteins might be involved in these diseases and review current knowledge on this very interesting trio of transcription factors that was previously only suspected to be involved in cancer.
Alarcón-Riquelme
Marta E
ME
Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden. marta.alarcon@genpat.uu.se
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D001327:Autoimmune Diseases / Q000235:genetics*; D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008177:Lupus Vulgaris / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D011565:Psoriasis / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
D050676:Core Binding Factor Alpha 2 Subunit; D050677:Core Binding Factor Alpha 3 Subunit; D050657:Core Binding Factor alpha Subunits; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; C493728:RUNX1 protein, human; C493729:Runx3 protein, human; D014157:Transcription Factors