title: CysView: protein classification based on cysteine pairing patterns.
abstract: CysView is a web-based application tool that identifies and classifies proteins according to their disulfide connectivity patterns. It accepts a dataset of annotated protein sequences in various formats and returns a graphical representation of cysteine pairing patterns. CysView displays cysteine patterns for those records in the data with disulfide annotations. It allows the viewing of records grouped by connectivity patterns. CysView's utility as an analysis tool was demonstrated by the rapid and correct classification of scorpion toxin entries from GenPept on the basis of their disulfide pairing patterns. It has proved useful for rapid detection of irrelevant and partial records, or those with incomplete annotations. CysView can be used to support distant homology between proteins. CysView is publicly available at http://research.i2r.a-star.edu.sg/CysView/.
authors.affiliation: Institute for Infocomm Research, 21 Heng Mui Keng Terrace, 119613 Singapore.
authors.forename: Johann
authors.initials: J
authors.lastname: Lenffer
authors.forename: Paulo
authors.initials: P
authors.lastname: Lai
authors.forename: Wafaa
authors.initials: W
authors.lastname: El Mejaber
authors.forename: Asif M
authors.initials: AM
authors.lastname: Khan
authors.forename: Judice L Y
authors.initials: JL
authors.lastname: Koh
authors.forename: Paul T J
authors.initials: PT
authors.lastname: Tan
authors.forename: Seng H
authors.initials: SH
authors.lastname: Seah
authors.forename: Vladimir
authors.initials: V
authors.lastname: Brusic
mesh_terms: D003196:Computer Graphics; D003545:Cysteine / Q000032:analysis*; D004220:Disulfides / Q000737:chemistry; D020407:Internet; D011506:Proteins / Q000737:chemistry / Q000145:classification*; D012604:Scorpion Venoms / Q000737:chemistry / Q000145:classification; D012984:Software; D014584:User-Computer Interface
chemical_list: D004220:Disulfides; D011506:Proteins; D012604:Scorpion Venoms; D003545:Cysteine