Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation.
Oral retinoids can reduce basal cell carcinoma (BCC) incidence in genetically susceptible patients, and one topical retinoid, tazarotene, has been reported to cure some sporadic BCCs. Therefore, we have tested whether this agent would affect BCCs in Ptch1+/- mice in a controlled chemoprevention trial. We found that topical tazarotene dramatically inhibits the formation of BCCs induced with either UV or ionizing radiation. The ability of tazarotene to inhibit BCC formation in this mouse model provides encouragement for the use of tazarotene in skin cancer chemoprevention trials in humans.
So
Po-Lin
PL
Department of Dermatology, University of California, San Francisco, California, USA.
Lee
Kenneth
K
Hebert
Jennifer
J
Walker
Patricia
P
Lu
Ying
Y
Hwang
Jimmy
J
Kopelovich
Levy
L
Athar
Mohammed
M
Bickers
David
D
Aszterbaum
Michelle
M
Epstein
Ervin H
EH
D000287:Administration, Topical; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D020022:Genetic Predisposition to Disease; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D009539:Nicotinic Acids / Q000008:administration & dosage*; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011506:Proteins / Q000235:genetics*; D011956:Receptors, Cell Surface; D012878:Skin Neoplasms / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D014466:Ultraviolet Rays / Q000009:adverse effects; D012176:Retinoids
D016588:Anticarcinogenic Agents; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009539:Nicotinic Acids; D000072079:Patched Receptors; D000072081:Patched-1 Receptor; D011506:Proteins; D011956:Receptors, Cell Surface; C000606236:PTCH1 protein, human; C000606240:Ptch1 protein, mouse; C086827:tazarotene; D012176:Retinoids