Physiologic correlates of distal lung inflammation in asthma.
BACKGROUND
The distal lung is an important site of inflammation in asthma. Maximal midexpiratory flows and the ratio of maximal:partial flows are purported to reflect distal lung function.


OBJECTIVE
We obtained contemporaneous transbronchial biopsy, spirometry, and plethysmography to describe more accurately the relationship between physiology and distal lung inflammation in asthma.


METHODS
Ten patients with severe, persistent asthma with mean +/- SE FEV(1) of 2.8 +/- 0.2 L and overnight fall in FEV(1) of 22.8% +/- 3.8% underwent transbronchial biopsy, spirometry, maximal midexpiratory flows, maximal:partial ratio, and lung volumes, all at 4 am. Morphometric analysis was performed after immunohistochemistry for eosinophils, lymphocytes, macrophages, mast cells, and neutrophils.


RESULTS
Maximal midexpiratory flows, maximal:partial ratio, FEV(1), and forced vital capacity were not significantly correlated with alveolar tissue inflammation. However, the degree of eosinophilic alveolar inflammation was significantly and positively correlated with both total lung capacity (Spearman rho=0.70; P=.03) and thoracic gas volume (rho=0.62; P=.05). Correlation between eosinophils and other lung volumes was not observed. Other inflammatory cell types did not correlate with lung volumes.


CONCLUSIONS
Purported physiologic measures of distal lung function are poorly correlated with histopathologic evidence of distal lung inflammation. Measurement of lung volumes more accurately reflects eosinophilic distal lung inflammation.
Sutherland
E Rand
ER
Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, J-217, Denver, CO 80206, USA. sutherlande@njc.org
Martin
Richard J
RJ
Bowler
Russell P
RP
Zhang
Yujun
Y
Rex
Michael D
MD
Kraft
Monica
M
D000328:Adult; D001249:Asthma / Q000473:pathology* / Q000503:physiopathology*; D004802:Eosinophilia / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D008176:Lung Volume Measurements; D008297:Male; D008450:Maximal Midexpiratory Flow Rate