title: Assessment of reliability endometrial brush cytology in detection etiology of late postmenopausal bleedings.
abstract: We evaluated the possibility of discovering bleeding causes in late postmenopausal period with cytological examination of material received by endometrial brush in comparison with Pap test and fractionated curettage. Sixty-two women in late postmenopausal period with cervical canal bleeding, treated in gynecological department of clinical hospital in Osijek, were cytological and histological processed. Final diagnosis in 29 from 62 (46.8%) women with late postmenopausal bleeding was cancer. 25 (40.3%) women had endometrial adenocarcinoma and 4 (6.5%) of them had squamous endocervical carcinoma. Two women had endometrial precancerous (3.2%). With Pap test accurate diagnosis was set up in 13 from 25 (52.0%) women with endometrial adenocarcinoma and in all of them with squamous endocervical carcinoma. With endometrial brush accurate diagnosis was set up in 14 from 25 (56.0%) women with endometrial adenocarcinoma and in 3 from 4 (75.0%) women with squamous endocervical carcinoma. With fractional curettage the diagnosis of endometrial adenocarcinoma was accurately correct in 21 from 25 (84.0%) women and in all of them with squamous endocervical carcinoma. Cytological examination of material derived with endometrial brush, alike vaginal cytology, is not enough reliable method in our conditions for discovering bleeding causes in late postmenopausal period. Diagnostic exactness of procedure could be increased by histopathological examination of material from endometrial brush procedure and with ultrasound evaluation of endometrium thickness.
authors.affiliation: Department of Gynecology and Obstetrics, Clinical Hospital Osijek, J. Huttler 4, 31000 Osijek, Croatia. milojkovic_dr@net.hr
authors.forename: Miodrag
authors.initials: M
authors.lastname: Milojkovic
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Hrgovic
authors.forename: Nicolai
authors.initials: N
authors.lastname: Maass
authors.forename: Walter
authors.initials: W
authors.lastname: Jonat
authors.forename: Igor
authors.initials: I
authors.lastname: Hrgovic
authors.forename: Damir
authors.initials: D
authors.lastname: Buković
authors.forename: Sinisa
authors.initials: S
authors.lastname: Sijanovic
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology; D003475:Curettage / Q000379:methods; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology*; D004717:Endometrium / Q000166:cytology*; D005260:Female; D006801:Humans; D017698:Postmenopause; D011230:Precancerous Conditions / Q000150:complications / Q000473:pathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014592:Uterine Hemorrhage / Q000209:etiology; D014626:Vaginal Smears / Q000379:methods