title: Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.
abstract: There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
authors.affiliation: Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Pedram
authors.initials: P
authors.lastname: Hamrah
authors.forename: Claus
authors.initials: C
authors.lastname: Cursiefen
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Bronislaw
authors.initials: B
authors.lastname: Pytowski
authors.forename: J Wayne
authors.initials: JW
authors.lastname: Streilein
authors.forename: M Reza
authors.initials: MR
authors.lastname: Dana
mesh_terms: D000818:Animals; D016039:Corneal Transplantation / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000276:immunology*; D006023:Glycoproteins; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007634:Keratitis / Q000276:immunology*; D042583:Lymphangiogenesis / Q000276:immunology*; D026901:Membrane Transport Proteins; D051379:Mice; D008856:Microscopy, Fluorescence; D023421:Models, Animal; D015398:Signal Transduction / Q000276:immunology*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D033921:Vesicular Transport Proteins
chemical_list: D006023:Glycoproteins; D026901:Membrane Transport Proteins; D042582:Vascular Endothelial Growth Factor C; D040321:Vascular Endothelial Growth Factor Receptor-3; D033921:Vesicular Transport Proteins; C119248:LYVE1 protein, human; C492273:LYVE1 protein, mouse