Differential expression of manganese containing superoxide dismutase in patients with breast cancer in Taiwan.
This study used Western blot analysis to measure the expression of superoxide dismutases (Mn-SOD and Cu/Zn-SOD) in breast cancer tissues from 57 patients. Mn-SOD expression in the breast cancer tissues averaged 1.5-fold higher than in the adjacent tumor-free tissues (p <0.05). There was no significant difference in Cu/Zn-SOD expression between neoplastic and tumor-free breast tissues. This study shows a significant increase of Mn-SOD expression in breast cancer tissues. The authors speculate that up-regulation of Mn-SOD expression induced by oxidative stress or local inflammation may contribute a selective growth advantage to tumor cells compared to their normal counterparts.
Er
Tze-Kiong
TK
Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
Hou
Ming-Feng
MF
Tsa
Eing-Mei
EM
Lee
Jau-Nan
JN
Tsai
Li-Yu
LY
D015153:Blotting, Western; D001943:Breast Neoplasms / Q000201:enzymology*; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology; D005260:Female; D006801:Humans; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*; D013624:Taiwan
D013482:Superoxide Dismutase