title: Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.
abstract: The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.
authors.affiliation: UMR 5091 CNRS-Université Bordeaux 2, Bordeaux 33077, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Groc
authors.forename: Martin
authors.initials: M
authors.lastname: Heine
authors.forename: Laurent
authors.initials: L
authors.lastname: Cognet
authors.forename: Kieran
authors.initials: K
authors.lastname: Brickley
authors.forename: F Anne
authors.initials: FA
authors.lastname: Stephenson
authors.forename: Brahim
authors.initials: B
authors.lastname: Lounis
authors.forename: Daniel
authors.initials: D
authors.lastname: Choquet
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies; D002232:Carbocyanines / Q000493:pharmacokinetics; D002478:Cells, Cultured; D006624:Hippocampus / Q000166:cytology*; D009474:Neurons / Q000378:metabolism*; D011189:Potassium Chloride / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D021381:Protein Transport / Q000502:physiology; D051381:Rats; D018091:Receptors, AMPA / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013569:Synapses / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000906:Antibodies; D002232:Carbocyanines; C409466:NR1 NMDA receptor; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C089187:cyanine dye 3; D013779:Tetrodotoxin; D011189:Potassium Chloride; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate; C104722:glutamate receptor ionotropic, AMPA 2