[Relationship between organochlorine pollution in soil and rice and the incidence of colorectal cancer in Jiashan county, Zhejiang province].
OBJECTIVE
To study the relationship between organochlorine and colorectal cancer.


METHODS
With multistage cluster random sampling, 11 towns were drawn based on the standardized incidence of colorectal cancer. Administrative and natural villages were drawn subsequently. Rice and soil samples in the paddy fields were collected in the villages. The contents of organochlorine were detected. Rank correlation analysis was performed together with the data of colorectal cancer incidence.


RESULTS
The contents of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in both rice and soil samples were below the amounts of the country. Statistics showed that the standardized incidence rates were significantly different among the 11 towns. The contents of delta-HCH, gamma-HCH, sodium pentachlorophenate in rice and those of delta-HCH in soil were statistically different among the towns through the rank sum test. The standardized incidence of colorectal cancer was significantly connected with the content of total DDT in rice while rectal cancer with total DDT and PP'-DDE and colon cancer with 1245 of polychlorinated biphenyl (PCBs). The correlation coefficients were 0.636, 0.691, 0.716 and 0.658 respectively (P < 0.05).


CONCLUSIONS
Rectal cancer was statistically correlated with organochlorine, mainly for total DDT and dichlorodiphenyldichloroethylene (PP'-DDE). Colon cancer was significantly associated with 1245 of PCBs. Further study should be performed since this research was only an ecological study.
Chen
Kun
K
Department of Epidemiology, School of Medicine Zhejiang University, Hangzhou 310006, China.
Zhao
Yu-Wan
YW
Ma
Xin-Yuan
XY
Zhang
Li-Jun
LJ
Zheng
Shu
S
D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D003634:DDT / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis*; D001556:Hexachlorocyclohexane / Q000009:adverse effects / Q000032:analysis*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects / Q000032:analysis; D015994:Incidence; D007306:Insecticides / Q000009:adverse effects / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012275:Oryza / Q000737:chemistry; D010573:Pesticide Residues / Q000009:adverse effects / Q000032:analysis*; D012989:Soil Pollutants / Q000032:analysis
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D010573:Pesticide Residues; D012989:Soil Pollutants; D001556:Hexachlorocyclohexane; D003634:DDT; C023888:beta-hexachlorocyclohexane