Inhibition of osteoporosis induced by protein deficient (PD) food intake by active vitamin D(3) and vitamin K(2) in rats.
Independent use of K(2) and D(3) and simultaneous application of K(2) and D(3) inhibited the development of osteoporosis caused by PD food intake. The ALP activity of urine as a marker of bone formation osteoporosis did not rise in rats fed PD foods containing D(3), K(2) or both together. Body and womb weights fell in rats fed PD foods with D(3) K(2) and both D(3), K(2). Osteoporosis caused by PD food intake found to be very similar to type II osteoporosis in respects of inhibition by D(3) and K(2) and rising urinary ALP activity.
Sun
Liman
L
Laboratories of Applied Biochemistry, Faculty of Agriculture, University of the Ryukyus, Okinawa, Japan.
Tamaki
Hajime
H
Ohta
Yutaka
Y
Katsuyama
Naofumi
N
Ishimaru
Tetsuji
T
Chinen
Isao
I
D000469:Alkaline Phosphatase / Q000652:urine; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D002762:Cholecalciferol / Q000494:pharmacology*; D018753:Diet, Protein-Restricted / Q000009:adverse effects*; D005260:Female; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D024482:Vitamin K 2 / Q000494:pharmacology*
D024482:Vitamin K 2; D002762:Cholecalciferol; D000469:Alkaline Phosphatase