[Immuno-metabolic effects of lysozyme in acute blood loss].
Lysozyme injections (1 or 5 mg/kg) produced marked immunomodulating, antioxidant and hepatoprotective effects in Wistar rats which had lost much blood (3% body mass). Lysozyme action is mediated by heavy erythrocytes and glass-adherent splenocytic cytokines the production of which is provoked by these erythrocytes.
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D000818:Animals; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects; D005980:Glutathione Reductase / Q000187:drug effects / Q000378:metabolism; D006470:Hemorrhage / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D009113:Muramidase / Q000276:immunology / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism
D017077:Culture Media, Conditioned; D016207:Cytokines; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D009113:Muramidase