[A case of combined hepatocellular-cholangiocarcinoma with sarcomatous transformation and second primary colon cancer].
Combined hepatocellular-cholangiocarcinoma is a rare form of primary liver cancer, featuring both hepatocellular and biliary epithelial differentiations. An intrahepatic tumor may be considered as a metastatic lesion. It has been suggested in the literature that the likelihood of metastasis in the cirrhotic liver is lower than that in the non-cirrhotic liver. A rare case of combined hepatocellular-cholangiocarcinoma and second primary colon adenocarcinoma in a 67-year-old male patient with liver cirrhosis is presented. Histologically, the intrahepatic mass was composed of a spindle cell sarcomatous component; a hepatocellular carcinoma component; and a cholangiocarcinoma component. There were focal transitional regions among the different components. Immunohistochemically, the cholangiocarcinoma component of the intrahepatic mass showed positive reactions for CK-7 but negative reactions for CK-20. The adenocarcinoma of the colon showed positive reactions for CK-20 but negative reactions for CK-7.
Kim
Jae Hi
JH
Department of Internal Medicine, College of Medicine, Pochon CHA University, Korea.
Lee
Yong Gu
YG
Lee
Jun
J
Jung
Cheol Kweon
CK
Kim
Hyeong Tae
HT
Kang
Haeyoun
H
Kho
Kwang Hyun
KH
Hong
Sung Pyo
SP
Hwang
Seong Gyu
SG
Park
Pil Won
PW
Rim
Gyu Sung
GS
D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*