Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents.
Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro anticancer activity.
Kamal
Ahmed
A
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.res.in
Srinivas
O
O
Ramulu
P
P
Ramesh
G
G
Kumar
P Praveen
PP
D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry*; D054831:Acridones; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry*; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000166:Acridines; D054831:Acridones; D001569:Benzodiazepines; C041300:acridone; D004247:DNA