title: Comparison of closed-loop and open-loop models in the assessment of cardiopulmonary and baroreflex gains.
abstract: OBJECTIVE
  Both open- and closed-loop models of beat-to-beat cardiovascular control have been suggested. We tested whether the modelling yields different results with real data while assessing cardiopulmonary and baroreflex gains.
  
  
  METHODS
  Two autoregressive models are described to resolve causal relationships between systolic blood pressure (SBP), RR-interval (RRI) and instantaneous lung volume (ILV): a closed-loop model which takes into account both the RRI changes induced by changes in SBP and the SBP changes mediated by changes in RRI, and an open-loop model which does not have a link from RRI to SBP. The performance of the models was compared in 14 healthy men in supine and standing positions under control conditions and under conditions of beta -sympathetic and parasympathetic pharmacological blockades. Transfer function gains were computed from ILV to RRI (cardiopulmonary gain) and from SBP to RRI (baroreflex gain). The measurements were done under controlled random-interval breathing.
  
  
  RESULTS
  The gains identified by the open-loop model tended to be higher than those from the closed-loop model, but the differences did not reach statistical significance. Importantly, the two models discriminated the changes in transfer gains between different interventions equally well.
  
  
  CONCLUSIONS
  Because the interactions between SBP and RRI occur physiologically in a closed-loop condition, the closed-loop model provides a theoretical advantage over the open-loop model. However, in practise, it seems to be little reason to select one over the other due to methodological errors when estimating cardiopulmonary or baroreflex transfer gains.
authors.affiliation: VTT Information Technology, PO Box 1206, 33101 Tampere, Finland. Ilkka.Korhonen@vtt.fi
authors.forename: R
authors.initials: R
authors.lastname: Takalo
authors.forename: J P
authors.initials: JP
authors.lastname: Saul
authors.forename: I
authors.initials: I
authors.lastname: Korhonen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage; D000328:Adult; D001285:Atropine / Q000008:administration & dosage; D017704:Baroreflex / Q000187:drug effects / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002307:Cardiography, Impedance; D005583:Fourier Analysis; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D011433:Propranolol / Q000008:administration & dosage; D016683:Supine Position / Q000502:physiology
chemical_list: D000319:Adrenergic beta-Antagonists; D001285:Atropine; D011433:Propranolol