PI3K signaling controls cell fate at many points in B lymphocyte development and activation.
Many receptors on diverse cell types activate phosphoinositide 3-kinase (PI3K). The lipid products of PI3K, termed 3-phosphoinositides, regulate numerous cellular processes by recruiting specific proteins to membrane signaling complexes. In the B lymphocyte lineage, PI3K activation is a critical control point at various stages of development, proliferation and differentiation. PI3K signaling is promoted by stimulatory receptors such as surface immunoglobulin, CD40, Toll-like receptors and cytokine receptors, and opposed by the inhibitory receptor FcgammaRIIB1. Genetic dissection of the PI3K pathway in mice has indicated that certain B cell functions are regulated by a limited set of PI3K isoforms and downstream effectors. Here we review our current understanding of how signals are relayed to and from PI3K in B cells.
Donahue
Amber C
AC
Department of Molecular Biology and Biochemistry, University of California, Irvine, 3242 McGaugh Hall, Irvine, CA 92697-3900, USA. adonahue@uci.edu
Fruman
David A
DA
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000201:enzymology* / Q000276:immunology; D002118:Calcium / Q000378:metabolism; D019070:Cell Lineage; D006801:Humans; D008213:Lymphocyte Activation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D019869:Phosphatidylinositol 3-Kinases; D002118:Calcium