Antimutagenic activity of lipidovit.
Antimutagenic properties of Lipidovit produced from the biomass of Blakeslea trispora fungi was studied by its effect on induction of chromosome aberrations by chemical mutagens dioxidine and cyclophosphamide in mouse bone marrow cells. Antimutagenic activity of Lipidovit depended on the scheme of treatment. It was maximum during pretreatment of animals (5 day) or administration in combination with mutagens (5 days). The preparation was ineffective after single administration in combination with mutagens. Lipidovit exhibited no comutagenic properties.
Avchieva
P B
PB
Federal State Unitary Company GosNIIsintezbelok, Moscow.
Tyurenkov
V A
VA
Butorova
I A
IA
Deev
S V
SV
Avchiev
M I
MI
Kulakova
A V
AV
Durnev
A D
AD
D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000187:drug effects; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009090:Mucorales / Q000737:chemistry; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity; D011810:Quinoxalines / Q000008:administration & dosage / Q000633:toxicity
D016587:Antimutagenic Agents; D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine; D003520:Cyclophosphamide