title: The demonstration of serum interleukin 6-8, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Behçet's disease with ocular involvement.
abstract: OBJECTIVE
  To investigate whether there are alterations in the humoral immune system in patients with Behçet's disease (BD) with ocular involvement.
  
  
  METHODS
  Twenty-four BD patients with active uveitis and without any other manifestations of the disease were included in Group I-a. The same patients were reassessed during the convalescence period and assigned to Group I-c. Moreover, 24 age- and sex-matched healthy controls (Group II) were included in the study. Serum levels of immunoglobulin (Ig) A, IgM, complement (C) 3, C4, interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) in Groups I-a, I-c, and II were measured and compared.
  
  
  RESULTS
  IgA, C3, C4, IL-6, IL-8, and TNF-alpha levels were higher in Group I-a than in Groups I-c and II.
  
  
  CONCLUSIONS
  IgA-, C3-, C4-, IL6-, IL8-, and TNF-alpha-mediated mechanisms might be responsible for ocular lesions in BD.
authors.affiliation: Department of Ophthalmology, Süleyman Demirel University Medical School, Isparta, Turkey. yavuzbardak@hotmail.com
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Bardak
authors.forename: Buket Cicioğlu
authors.initials: BC
authors.lastname: Aridoğan
mesh_terms: D000328:Adult; D000917:Antibody Formation; D001528:Behcet Syndrome / Q000276:immunology*; D003165:Complement System Proteins / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014605:Uveitis / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D003165:Complement System Proteins