Cerebral metabolism in severe neonatal hyperbilirubinemia.
The metabolism of the basal ganglia was examined by using proton magnetic resonance spectroscopy in 5 neonates with severe hyperbilirubinemia. A decreased N-acetylaspartate/choline ratio, indicating neuronal injury, and an abnormally high lactate/N-acetylaspartate ratio were found only in the neonate with neonatal magnetic resonance imaging abnormalities and subsequent cerebral palsy.
Groenendaal
Floris
F
Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands. f.groenendaal@wkz.azu.nl
van der Grond
Jeroen
J
de Vries
Linda S
LS
D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001479:Basal Ganglia / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood; D002547:Cerebral Palsy / Q000209:etiology; D002794:Choline / Q000378:metabolism; D016057:Evoked Potentials, Auditory, Brain Stem; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy
D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate; D002794:Choline; D001663:Bilirubin