Cerebral sinus thrombosis associated with severe active ulcerative colitis.
A 19-year-old man with severe active ulcerative colitis was admitted to our hospital where he was prescribed 80 mg prednisolone and underwent leukocytapheresis (LCAP). Two weeks after initiating therapy, his symptoms had not recovered. We administered cyclosporin via continuous intravenous infusion for 12 days. Although his clinical symptoms improved, he complained of severe headache. Immediate plain computed tomography (CT) and magnetic resonance imaging angiography (MRA) revealed extensive thrombosis in the superior sagittal sinus and right transverse sinus. We treated this condition with the anticoagulant agent, heparin, which prevents and can treat venous thrombosis. We report an occurrence of cerebral sinus thrombosis accompanying ulcerative colitis, where active anticoagulant therapy was useful.
Murata
Shizuka
S
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601.
Ishikawa
Naoto
N
Oshikawa
Shoutaro
S
Yamaga
Junichi
J
Ootsuka
Masaaki
M
Date
Haruhiko
H
Kitani
Michitaka
M
Inatsu
Haruhiko
H
Eto
Tanenao
T
D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000008:administration & dosage; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007937:Leukapheresis / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D011856:Radiographic Image Enhancement; D018570:Risk Assessment; D012720:Severity of Illness Index; D012812:Sigmoidoscopy / Q000379:methods; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D015912:Thrombolytic Therapy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
D016572:Cyclosporine; D006493:Heparin; D011239:Prednisolone