title: Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities.
abstract: Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compounds 6, 8, and 10, rigid mimetic structure of curcumin, showed the potent growth inhibitory activity and the potent tube formation inhibitory activity.
authors.affiliation: Department of Basic Sciences, Wonju College of Medicine, Yonsei University, Wonju 220-701, South Korea. ahn0707@wonju.yonsei.ac.kr
authors.forename: Chan Mug
authors.initials: CM
authors.lastname: Ahn
authors.forename: Woon-Seob
authors.initials: WS
authors.lastname: Shin
authors.forename: Ho
authors.initials: H
authors.lastname: Bum Woo
authors.forename: Seokjoon
authors.initials: S
authors.lastname: Lee
authors.forename: Hyean-Woo
authors.initials: HW
authors.lastname: Lee
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014471:Umbilical Veins
chemical_list: D020533:Angiogenesis Inhibitors; D011725:Pyridines; D013876:Thiophenes; D003474:Curcumin