title: Detection of Epstein-Barr virus in saliva by real-time PCR.
abstract: The purpose of this investigation was to assess the salivary levels of Epstein-Barr virus (EBV) in patients with periodontitis using real-time PCR. EBV was detected in 16 out of 33 (48.5%) periodontitis patients and in 3 out of 20(15%) healthy subjects. The baseline mean values for bleeding on probing in EBV-positive patients were significantly higher than those in EBV-negative patients. A significant decrease in EBV levels was observed after initial periodontal treatment. Our findings indicate that levels of EBV in saliva may reflect the status of periodontal inflammation.
authors.affiliation: Department of Periodontology, Dental Reseach Center, Nihon University Graduate School of Dentistry, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Idesawa
authors.forename: N
authors.initials: N
authors.lastname: Sugano
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Oshikawa
authors.forename: M
authors.initials: M
authors.lastname: Takane
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: K
authors.initials: K
authors.lastname: Ito
mesh_terms: D000328:Adult; D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000821:virology*; D016133:Polymerase Chain Reaction; D012463:Saliva / Q000821:virology*