Differential efficacy of clarithromycin in lung versus thigh infection models.
BACKGROUND
Differences in clarithromycin disposition and the resulting changes in bacterial density were studied using mouse lung and thigh infection models.


METHODS
Clarithromycin activity was evaluated against seven Streptococcus pneumoniae isolates with efflux-mediated resistance in both murine lung and thigh infection models. Intrapulmonary disposition of clarithromycin was also studied.


RESULTS
Consistent bacterial kill was observed in the lung model, whereas no drug effect was observed in the thigh model.


CONCLUSIONS
These differences in bacterial density were supported by high concentrations observed in epithelial lining fluid as compared to serum.
Maglio
Dana
D
Center for Anti-Infective Research and Development, Hartford Hospital, Conn., USA.
Capitano
Blair
B
Banevicius
Mary Anne
MA
Geng
Qiuming
Q
Nightingale
Charles H
CH
Nicolau
David P
DP
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017291:Clarithromycin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004195:Disease Models, Animal; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D008168:Lung / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification; D013848:Thigh / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D017291:Clarithromycin