Infarct extent by MRI correlates with peak serum troponin level in the canine model.
BACKGROUND
Serum Troponin I is used routinely as an adjunct to EKG for the diagnosis of myocardial infarction (MI); however, a correlation between marker level and infarct size has yet to be documented in vivo. We report findings from a chronic coronary artery ligation model in the canine (n = 12) in which peak Troponin I is related to infarct size as determined by high-resolution cardiac magnetic resonance imaging.


METHODS
All animals underwent a left anterior thoracotomy to allow for ligation of the left anterior descending artery. Evidence of myocardial infarction, including EKG changes, elevated Troponin I, along with visual reduction in perfusion and wall motion, was noted in all animals. Thirty days after surgical intervention, cine MRI and contrast-enhanced MRI were performed. Dedicated analysis software was used to quantify global infarction size, LV function and to map regions of MI to a 3D model of the left ventricle.


RESULTS
A linear relationship between infarct extent and peak Troponin I level exists (r = 0.98, P < 0.0001). In addition, we observed a negative trend between infarct extent, peak Troponin I, and ejection fraction.


CONCLUSIONS
The findings of this study indicate that Troponin I and cardiac magnetic resonance imaging provide a more accurate estimation of infarct size than was previously reported using markers with less sensitivity and imaging modalities of lower spatial resolution and viability imaging capability.
Gallegos
Robert P
RP
Division of Cardiovascular and Thoracic Surgery and Experimental Surgical Services, Department of Surgery, MMC 20, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455 USA. galle015@umn.edu
Swingen
Cory
C
Xu
Xunhai James
XJ
Wang
Xiaoen
X
Bianco
Richard
R
Jerosch-Herold
Michael
M
Bolman
R Morton
RM
D000818:Animals; D003097:Collateral Circulation; D003331:Coronary Vessels; D004195:Disease Models, Animal; D004285:Dogs; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008026:Ligation; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D009994:Osmolar Concentration; D013318:Stroke Volume; D014336:Troponin / Q000097:blood*
D014336:Troponin