[Spontaneous and mitogen-induced production of proinflammatory cytokines (interleukin-1 and tumor necrosis factor-alpha) in patients with chronic chlamydia infection of urogenital system].
The article contributes to studying functional activity of mononuclear and macrophage immune cells by spontaneous and induced production of IL-1 and TNF-alpha cytokines in patients with chronic urogenital clamidiosis. The patients with monoinfection were shown to have high level of IL-1 and low level of TNF-alpha, while the patients with mixed infection of urogenital tract presented with the high production of TNF-alpha. The cells activation raise cytokines production not to the level observed among healthy persons. It suggests decreasing compensatory regulation in yet higher activated cells.
Driians'ka
V Ie
VIe
Drannik
H M
HM
Vashchenko
S M
SM
Fesenkova
V I
VI
Papakina
V S
VS
D000328:Adult; D002690:Chlamydia Infections / Q000276:immunology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification; D002908:Chronic Disease; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology* / Q000382:microbiology; D005832:Genital Diseases, Male / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007375:Interleukin-1 / Q000276:immunology*; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D014552:Urinary Tract Infections / Q000276:immunology* / Q000382:microbiology
D007375:Interleukin-1; D008934:Mitogens; D014409:Tumor Necrosis Factor-alpha