In-vitro activity of nisin against clinical isolates of Clostridium difficile.
Nisin is a cationic peptide produced by Lactococcus lactis. Its activity against clinical isolates of Clostridium difficile was compared to that of vancomycin and metronidazole by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill studies. Nisin was more active than the other agents, with a MIC90 of 0.256 mg/L and strong bactericidal activity. Nisin may be a promising agent for the management of C. difficile associated diarrhea.
Bartoloni
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A
Clinica Malattie Infettive, Università di Firenze, Ospedale di Careggi, Viale Morgagni 85, I-50134 Florence, Italy. bartolonia@ao-careggi.toscana.it
Mantella
A
A
Goldstein
B P
BP
Dei
R
R
Benedetti
M
M
Sbaragli
S
S
Paradisi
F
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016360:Clostridioides difficile / Q000187:drug effects*; D003428:Cross Infection / Q000517:prevention & control; D004761:Enterocolitis, Pseudomembranous / Q000517:prevention & control; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009561:Nisin / Q000494:pharmacology* / Q000627:therapeutic use; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D009561:Nisin; D014640:Vancomycin