title: Cardiac chondrosarcoma producing parathyroid hormone-related protein.
abstract: Chondrosarcoma is a malignant tumor characterized by the formation of cartilage. A case of primary cardiac chondrosarcoma of the left atrium developed in a middle-aged male. The preoperative serum concentrations of C-parathyroid hormone-related protein (PTHrP) and calcium were high (413.2 pmol/L and 12.2 mg/dl, respectively), but normalized after resection of the tumor, which measured 7 x 5 x 3.5 cm. The tumor was histopathologically diagnosed as chondrosarcoma, composed of outer atypical chondroid cells and inner pleomorphic and spindle mesenchymal cells mimicking malignant fibrous histiocytoma. Half of the cartilaginous tumor cells and a few pleomorphic cells showed cytoplasmic immunoreactivity for PTHrP. The tumor is a possible example of the functional pleiotropy of chondrosarcoma.
authors.affiliation: Department of Laboratory Medicine, Tottori Perfectual Central Hospital, Tottori, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kase
authors.forename: Shu
authors.initials: S
authors.lastname: Nakamoto
authors.forename: Shigeto
authors.initials: S
authors.lastname: Miyasaka
authors.forename: Hisato
authors.initials: H
authors.lastname: Moritani
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiyama
authors.forename: Eizo
authors.initials: E
authors.lastname: Goto
authors.forename: Hironobu
authors.initials: H
authors.lastname: Adachi
authors.forename: Hisao
authors.initials: H
authors.lastname: Ito
mesh_terms: D002813:Chondrosarcoma / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006338:Heart Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein / Q000097:blood*; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D044162:Parathyroid Hormone-Related Protein