Lentiviral transduction of dendritic cells confers protective antiviral immunity in vivo.
Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.
Zarei
Shohreh
S
Department of Immunology and Allergy, University Hospital of Geneva, Geneva, Switzerland.
Abraham
Shahnaz
S
Arrighi
Jean-Francois
JF
Haller
Olivier
O
Calzascia
Thomas
T
Walker
Paul R
PR
Kündig
Thomas M
TM
Hauser
Conrad
C
Piguet
Vincent
V
D000818:Animals; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D005822:Genetic Vectors; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D049452:Green Fluorescent Proteins; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D008164:Luminescent Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000517:prevention & control; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology / Q000472:pathogenicity; D051379:Mice; D008810:Mice, Inbred C57BL; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014161:Transduction, Genetic; D014765:Viral Vaccines / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology
D006023:Glycoproteins; D008164:Luminescent Proteins; D011993:Recombinant Fusion Proteins; D014765:Viral Vaccines; D049452:Green Fluorescent Proteins