[Roles of CD45RO, CD20 and local IgE in the pathogenesis of vocal fold polyps].
OBJECTIVE
To investigate the roles of CD45RO, CD20 and local IgE in the pathogenesis of vocal fold polyps.


METHODS
Thirty cases of vocal fold polyps and ten cases of normal vocal folds were used in present study by immunohistochemical method to detect the CD45RO, CD20 and IgE cells. A mean numbers of positive cells per high power field(X 400) were counted. All data were analyzed with t-test and correl-test by SPSS10.0 software.


RESULTS
The number of CD45RO+ cells, CD20+ cells and local IgE cells in vocal fold polyps was significantly more than in normal vocal folds (P < 0.01). The expression of CD45RO+ cells, CD20+ cells and local IgE+ cells in vocal fold polyps was no connection relations. The expression of CD45RO+ cells, CD20+ cells and local IgE cells between male and female vocal fold polyps was no significant(P > 0.05).


CONCLUSIONS
There were active cellular immunity and humoral immunity in vocal fold polyps. Local allergy may play a role in the pathogenesis of vocal fold polyps.
Gao
Hongming
H
Department of Otorhinolaryngology, Second Clinical Hospital, Kunming Medical College, Kunming, 650031, China.
Wang
Zhengqiang
Z
Zheng
Mingxiu
M
Zhu
Jiawei
J
D000293:Adolescent; D000328:Adult; D018951:Antigens, CD20 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007818:Laryngeal Diseases / Q000209:etiology* / Q000378:metabolism; D017493:Leukocyte Common Antigens / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000209:etiology* / Q000378:metabolism; D014827:Vocal Cords / Q000276:immunology*
D018951:Antigens, CD20; D007073:Immunoglobulin E; D017493:Leukocyte Common Antigens