title: Identification of two teleost homologs of the Drosophila sex determination factor, transformer-2 in medaka (Oryzias latipes).
abstract: Transformer-2 (Tra2), an RNA-binding protein, is an important regulator in Drosophila sex determination. In vertebrates, however, the role of Tra2 homologues is not known. We identified two teleost homologues of Tra2, which we named Tra2a and Tra2b, in medaka (Oryzias latipes). Furthermore, we demonstrated that both Tra2 mRNAs were predominantly expressed in germ cells of both sexes before the onset of sex differentiation, suggesting that both Tra2 homologues might be involved in the sex differentiation in medaka.
authors.affiliation: Department of Materials and Life Science, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Kumamoto 860-8555, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Shiraishi
authors.forename: Hideo
authors.initials: H
authors.lastname: Imazato
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Hayato
authors.initials: H
authors.lastname: Yokoi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Abe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kitano
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D009990:Oryzias / Q000196:embryology / Q000235:genetics* / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment; D019849:Sex Determination Processes
chemical_list: D029721:Drosophila Proteins; D020033:Protein Isoforms; D012261:Ribonucleoproteins; C066174:tra2 protein, Drosophila