title: Efficient quadratic regularization for expression arrays.
abstract: Gene expression arrays typically have 50 to 100 samples and 1000 to 20,000 variables (genes). There have been many attempts to adapt statistical models for regression and classification to these data, and in many cases these attempts have challenged the computational resources. In this article we expose a class of techniques based on quadratic regularization of linear models, including regularized (ridge) regression, logistic and multinomial regression, linear and mixture discriminant analysis, the Cox model and neural networks. For all of these models, we show that dramatic computational savings are possible over naive implementations, using standard transformations in numerical linear algebra.
authors.affiliation: Departments of Statistics, and Health Research & Policy, Stanford University, Sequoia Hall, CA 94305, USA. hastie@stanford.edu
authors.forename: Trevor
authors.initials: T
authors.lastname: Hastie
authors.forename: Robert
authors.initials: R
authors.lastname: Tibshirani
mesh_terms: D003627:Data Interpretation, Statistical; D016014:Linear Models; D016015:Logistic Models; D015233:Models, Statistical; D016571:Neural Networks, Computer; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D016016:Proportional Hazards Models