The Nogo signaling pathway for regeneration block.
A hostile environment and decreased regenerative capacity may contribute to the failure of axon regeneration in the adult central nervous system. Recent studies leading to the identification of several myelin-associated inhibitors and their signaling molecules provide opportunitities to assess the contribution of these inhibitory molecules in restricting axon regeneration. These findings may ultimately allow for the development of strategies to alleviate the inhibitory effects of such molecules in an effort to encourage axon regeneration after spinal cord and brain injury.
He
Zhigang
Z
Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. zhigang.he@tch.harvard.edu
Koprivica
Vuk
V
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D020439:Growth Cones / Q000378:metabolism* / Q000648:ultrastructure; D006131:Growth Inhibitors / Q000378:metabolism*; D006801:Humans; D009185:Myelin Proteins / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D000070798:Nogo Proteins; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D006131:Growth Inhibitors; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; D011956:Receptors, Cell Surface