title: [Effect of Helicobacter pylori infection on the gastroesophageal reflux in patients with atypical chest pain].
abstract: The role of Helicobacter pylori (Hp) infection in the course of gastroesophageal reflux disease (GERD) is still controversial. The aim of this study was to compare the results of endoscopic, histologic and pH-metric examinations of esophagus in patients diagnosed because of atypical chest pain, infected and not-infected by Hp. In 172 patients diagnosed because of atypical chest pain were made: interview, physical examination, gastroduodenoscopy with esophageal and gastric mucosa biopsy as well as esophageal pH-metry. Hp infection was diagnosed on the basis of positive urease test or/and histologic examination. In 49 (28%) subjects pathological gastroesophageal acid reflux was diagnosed (above 4.5% of monitoring time with pH < 4). Percentage of Hp infected patients among subjects with pathological (69%) and not-pathological (74%) gastroesophageal acid reflux did not differ significantly. Hp infected patients, in comparison to Hp-negative, had similar esophageal mucosa endoscopic appearance and greater intensity of histologic changes in esophageal mucosa. Studied patients group did not differ in respect of esophageal pH-metry parameters values, besides of greater number of esophageal alkalization (pH > 7) episodes in Hp-negative subjects.
  
  
  CONCLUSIONS
  1) Hp infection was diagnosed in 72% of patients with atypical chest pain. 28% had pathological gastroesophageal acid reflux. 2) Gastroesophageal acid reflux was not related to Hp infection. 3) Greater intensity of histologic changes in esophageal mucosa of Hp-positive patients with accompanying lack of differences in endoscopic estimation and similar endanger on gastric acid in pH-metry suggests protective role of esophageal alkalization against esophageal mucosa injury or higher intensity of regenerative inflammatory processes in Hp-positive patients.
authors.affiliation: Katedra i Klinika Gastroenterologii, Chorób Naczyń i Chorób Wewnetrznych AM im. L. Rydygiera w Bydgoszczy.
authors.forename: Jacek
authors.initials: J
authors.lastname: Budzyński
authors.forename: Maria
authors.initials: M
authors.lastname: Kłopocka
authors.forename: Maciej
authors.initials: M
authors.lastname: Swiatkowski
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Korenkiewicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Pulkowski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Grad
mesh_terms: D000328:Adult; D001944:Breath Tests; D002637:Chest Pain / Q000175:diagnosis* / Q000209:etiology; D016145:Endoscopy, Digestive System; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications* / Q000378:metabolism / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged