title: Developing novel activity-based fluorescent probes that target different classes of proteases.
abstract: In this article, we report the design and synthesis of a group of novel activity-based probes that target different protease sub-classes based on their substrate specificities, rather than their enzymatic mechanisms. The feasibility of our approach has been demonstrated by using representative members of the different protease sub-classes.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
authors.forename: Aparna
authors.initials: A
authors.lastname: Girish
authors.forename: Souvik
authors.initials: S
authors.lastname: Chattopadhaya
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000577:Amides / Q000737:chemistry; D010450:Endopeptidases / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis*; D040901:Proteomics; D013379:Substrate Specificity
chemical_list: D000577:Amides; D005456:Fluorescent Dyes; D010450:Endopeptidases