Therapeutic drug monitoring for patients with HIV infection: Children's National Medical Center, Washington DC experience.
This paper provides a brief overview of therapeutic drug monitoring (TDM) in patients with HIV infection. The manuscipt not only focuses on an update on TDM in HIV infection but also provides the latest information on tandem mass spectrometric methods for antiretroviral drug quantification. Also discussed are the preliminary new and original data on free antiretroviral drug measurement in both plasma and saliva.
Soldin
Steven J
SJ
Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA. ssoldin@cnmc.org
Rakhmanina
Natella Y
NY
Spiegel
Hans M L
HM
Sever
John L
JL
D019380:Anti-HIV Agents / Q000032:analysis* / Q000097:blood; D002648:Child; D002851:Chromatography, High Pressure Liquid; D016903:Drug Monitoring; D015658:HIV Infections / Q000188:drug therapy*; D006776:Hospitals, Pediatric; D006801:Humans; D013058:Mass Spectrometry; D011485:Protein Binding; D012463:Saliva / Q000737:chemistry
D019380:Anti-HIV Agents