Reduced neuropeptide Y mRNA expression in the central nucleus of amygdala of alcohol preferring (P) rats: its potential involvement in alcohol preference and anxiety.
Levels of neuropeptide Y (NPY) mRNA expression in discrete brain regions of alcohol preferring (P) rats and alcohol nonpreferring (NP) rats were examined using in situ hybridization. NPY mRNA expression was significantly lower in the central nucleus of amygdala (CeA) of P rats than NP rats, whereas no differences were found in the medial or basolateral amygdaloid nuclei. This study suggests that reduced NPY gene expression in the CeA may contribute to differences in alcohol preference and other behavioral differences observed between P and NP rats.
Suzuki
Ryoji
R
Department of Anatomy and Cell Biology (MS-5035), Indiana University School of Medicine, 635 North Barnhill Drive, Indianapolis, IN 46202-5120, USA.
Lumeng
Lawrence
L
McBride
William J
WJ
Li
Ting-Kai
TK
Hwang
Bang H
BH
D000428:Alcohol Drinking / Q000235:genetics* / Q000378:metabolism*; D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D015870:Gene Expression; D017403:In Situ Hybridization; D008297:Male; D009478:Neuropeptide Y / Q000235:genetics*; D010641:Phenotype; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D014158:Transcription, Genetic
D009478:Neuropeptide Y; D012333:RNA, Messenger