title: Comparison of systolic cardiac function before and after treatment of atrial fibrillation in horses with and without additional cardiac valve insufficiencies.
abstract: Clinical, electrocardiographic and echocardiographic examinations were conducted before therapy and 4 days after conversion to normal sinus rhythm in 15 horses with a history of atrial fibrillation of 2-6 months duration. Seven horses showed no other signs of cardiac disease. Four horses suffered additionally from mitral valve insufficiency, while six horses had aortic valve insufficiency, including two of the four horses with mitral valve insufficiency, but none had signs of congestive heart failure. Doppler echocardiographic estimates of various variables were made for assessment of systolic heart function. These included heart rate, stroke volume, cardiac output and cardiac output per kg of body weight (heart index). After conversion to normal sinus rhythm, the horses without heart valve insufficiency showed a statistically significantly decreased heart rate (-24%) and cardiac output (-3%), but an increase in stroke volume (+8.4%) and heart index (+9%). The horses with heart valve insufficiency experienced a statistically significant decrease in heart rate (-21%) after conversion to normal sinus rhythm, but showed an increase in all other variables. Cardiac output increased statistically significantly by 20%, stroke volume by 54% and heart index by 58%.
authors.affiliation: Clinic for Horses, School of Veterinary Medicine Hannover, Bischofsholer Damm 12, D-30173 Hannover, Germany. heidrun.gehlen@tiho-hannover.de
authors.forename: H
authors.initials: H
authors.lastname: Gehlen
authors.forename: P
authors.initials: P
authors.lastname: Stadler
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000503:physiopathology / Q000662:veterinary*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D002302:Cardiac Output / Q000502:physiology; D015150:Echocardiography, Doppler / Q000662:veterinary; D004562:Electrocardiography / Q000662:veterinary; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006734:Horse Diseases / Q000188:drug therapy / Q000503:physiopathology*; D006736:Horses; D008297:Male; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000503:physiopathology / Q000662:veterinary*; D011802:Quinidine / Q000627:therapeutic use
chemical_list: D000889:Anti-Arrhythmia Agents; D011802:Quinidine