title: High-dose exposure to valsartan with suicidal intention.
abstract: Valsartan is a strong angiotensin receptor inhibitor specific for the angiotensin I receptor, which has been proven safe and well-tolerated in clinical trials. We were able to confirm its safety and tolerability in a case of high-dose exposure to valsartan with suicidal intention. A 25-year-old, fully conscious, female patient was brought to our hospital by relatives on July 24, 2001, at 9:15 p.m. following intake of a high dose of valsartan. It was established that she had taken 28 Diovan 80 mg tablets (2.24 g) 5 hours before admission to the hospital. Her clinical condition at the time of admission was good and did not deteriorate after admission. During the follow-up, her blood pressure never fell below 90/60 mmHg. The only complaint she had were painful muscle cramps which, with only supportive therapy, disappeared spontaneously over 2 days, and her blood pressure also returned to normal during this period. This report demonstrates the effect/side effect profile of valsartan when taken at a high dose, not achievable in a clinical trial.
authors.affiliation: 3rd Internal Medicine Clinic, Haseki Hospital, Istanbul, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Kumbasar
authors.forename: F
authors.initials: F
authors.lastname: Atlibatur Akbas
authors.forename: K
authors.initials: K
authors.lastname: Serez
authors.forename: E
authors.initials: E
authors.lastname: Ger
authors.forename: S
authors.initials: S
authors.lastname: Uzunoglu
authors.forename: K
authors.initials: K
authors.lastname: Ergen
authors.forename: M
authors.initials: M
authors.lastname: Ayer
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000506:poisoning*; D005260:Female; D006801:Humans; D013406:Suicide, Attempted; D013777:Tetrazoles / Q000506:poisoning*; D014633:Valine / Q000031:analogs & derivatives / Q000506:poisoning*; D000068756:Valsartan
chemical_list: D000959:Antihypertensive Agents; D013777:Tetrazoles; D000068756:Valsartan; D014633:Valine