In vitro activities of iodonium salts against oral and dental anaerobes.
The comparative in vitro activities of 11 iodonium salt compounds, 0.12% chlorhexidine, and four antimicrobial agents against 322 anaerobic and fastidious potential dental and periodontal bacterial pathogens were studied. Iodonium salts 3, 4, 5, 9, and 10 had in vitro activities comparable to that of chlorhexidine against most isolates. These compounds may be suitable for incorporation into an oral mouthwash.
Goldstein
Ellie J C
EJ
R. M. Alden Research Laboratory, 2021 Santa Monica Blvd., Suite 740 E, Santa Monica, CA 90404, USA. ejcgmd@aol.com
Citron
Diane M
DM
Warren
Yumi
Y
Merriam
C Vreni
CV
Tyrrell
Kerin
K
Fernandez
Helen
H
Radhakrishnan
Ukkiramapandian
U
Stang
Peter J
PJ
Conrads
Georg
G
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002710:Chlorhexidine / Q000494:pharmacology; D004202:Disinfectants / Q000494:pharmacology; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D009067:Mouthwashes / Q000494:pharmacology; D009861:Onium Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014070:Tooth / Q000382:microbiology*
D000890:Anti-Infective Agents; D004202:Disinfectants; D009067:Mouthwashes; D009861:Onium Compounds; D002710:Chlorhexidine