5-Exo-dig radical cyclization of enediynes: the first synthesis of tin-substituted benzofulvenes.
[reaction: see text] Bu(3)Sn-mediated 5-exo-dig radical cyclization of diaryl enediynes provides a mild and efficient approach to tin-substituted fulvenes. Further synthetic opportunities opened by this process and general factors responsible for the observed regio- and stereoselectivity are outlined.
Kovalenko
Serguei V
SV
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306-4390, USA.
Peabody
Scott
S
Manoharan
Mariappan
M
Clark
Ronald J
RJ
Alabugin
Igor V
IV