title: Prostacyclin analogue (beraprost) relief of cold intolerance after digital replantation and revascularization.
abstract: Cold intolerance frequently occurs after successful digital revascularization and replantation. A series of 11 patients with cold intolerance 6 to 24 months after digital revascularization/replantation were treated daily for 2 weeks with beraprost, a stable prostacyclin analogue. That pain was reduced in 9 of 11 cases after treatment and digital thermography showed significantly increased surface temperature after the 2-week course of beraprost. These findings support the use of beraprost to relieve symptoms of cold intolerance under these clinical conditions.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Kinki University School of Medicine, Osaka-sayama, Japan. isogai@med.kindai.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Isogai
authors.forename: Y
authors.initials: Y
authors.lastname: Miyasato
authors.forename: S
authors.initials: S
authors.lastname: Asamura
mesh_terms: D000328:Adult; D003080:Cold Temperature / Q000009:adverse effects*; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005383:Finger Injuries / Q000601:surgery*; D005385:Fingers / Q000098:blood supply* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D012092:Replantation / Q000009:adverse effects*; D013817:Thermography; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; C048081:beraprost; D011464:Epoprostenol