[Comparative study on a short-term curative result between Nissen, Thal and Toupet fundoplications].
OBJECTIVE
To compare the short-term curative results between Nissen, Thal and Toupet fundoplications in treatment of gastroesophageal reflux (GER) and to provide the basis for operative procedure.


METHODS
Thirty-three male Japan rabbits were randomly divided into six groups: group reflux (n = 7), transabdominal Heller's esophagomyotomy (TAHE); group Nissen (n = 7), TAHE and Nissen fundoplication; group Thal (n = 7), TAHE and Thal fundoplication; group Toupet (n = 7), TAHE and Toupet fundoplication; control group (n = 5), ventrotomy. The anti-reflux efficacy of fundoplication was evaluated by intraesophageal pH monitoring and MGV (maximal gastric volume sustained by lower esophageal sphincter) 4 weeks postoperatively.


RESULTS
1. The total number of reflux episodes and the reflux ratio (0.83 +/- 0.41, 2.20% +/- 1.12%) of group Nissen were significantly lower than those of group Thal (2.20 +/- 0.45, 4.32% +/- 0.82%) and group Toupet (1.80 +/- 0.45, 4.20% +/- 0.57%), respectively (P < 0.05). 2. MGV of group Nissen (233.00 +/- 9.44)ml was significantly larger than those of group Thal (203.40 +/- 11.13)ml and group Toupet (197.60 +/- 10.99)ml, respectively (P < 0.05). 3. There were no significant difference in total number of reflux episodes, reflux ratio and MGV between group Thal and group Toupet (P > 0.05).


CONCLUSIONS
Nissen fundoplication was better than Thal and Toupet fundoplications, Thal and Toupet fundoplications are similar in short-term curative result.
Xu
Zhicheng
Z
Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
Hu
Tingze
T
Liu
Wenying
W
D000818:Animals; D004943:Esophagogastric Junction / Q000601:surgery*; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D011817:Rabbits; D011897:Random Allocation; D013997:Time Factors; D016896:Treatment Outcome