title: [A case of breast cancer with multiple bone metastases demonstrating complete remission with high-dose toremifene therapy].
abstract: We report a 64-year-old woman who underwent mastectomy for stage II (T2N1M0) advanced breast cancer, in whom multiple spine metastases developed 18 months postoperatively. She received 6 cycles of CA (cyclophosphamide 500 mg/m2, ADM 50 mg/m2 3 wq) therapy and oral tamoxifen (20 mg/body) administration for adjuvant therapy. The multiple bone metastases of the spine were revealed by technetium bone scan. The level of serum tumor marker CA15-3 increased two times over the normal range 18 months after surgery. She also developed osteoporosis a few years later, so we selected high-dose toremifene administration (120 mg/body) as a second-line therapy. No adverse effects have occurred and bone metastases disappeared. Moreover, the tumor marker was also normalized 6 months after toremifene therapy started. It was shown that high-dose treatment of toremifene was useful for recurrent breast cancer with bone metastasis.
authors.affiliation: Dept. of Breast and Endocrine Surgery, Nihon University School of Medicine.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Saito
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Kashio
authors.forename: Hideo
authors.initials: H
authors.lastname: Abe
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kuboi
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Aoki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hata
authors.forename: Nanao
authors.initials: N
authors.lastname: Negishi
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D001859:Bone Neoplasms / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary*; D017024:Chemotherapy, Adjuvant; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D012074:Remission Induction; D017312:Toremifene / Q000008:administration & dosage*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017312:Toremifene