Vasoconstrictively acting AT1R A1166C and NOS3 4/5 polymorphisms in recurrent spontaneous abortions (RSA).
OBJECTIVE
Inadequate uteroplacental perfusion is one of the main reasons for recurrent spontaneous abortions (RSA). Coagulation, fibrinolysis, and vasoconstriction affect tissue perfusion. These systems are regulated by different gene products. Polymorphisms can modulate the expression levels of the respective genes and can thereby affect perfusion. Vasoconstriction is influenced by the expression of endothelial nitric oxide synthase (eNOS) and of the angiotensinogen II type 1 receptor (AT1R).


METHODS
The aim of our study was to investigate, whether two polymorphisms in the AT1R and NOS3 genes shown to result in maternal vasoconstriction are associated with an increased risk for RSA.


RESULTS
Our data indicate that the vasoconstrictively acting genotypes AT1R C/C and NOS3 4/4 are of similar prevalence in RSA patients and in controls.


CONCLUSIONS
Results do not show any influence of the polymorphisms studied on early pregnancy development. This is in concordance with the concept of an independent regulation of placental perfusion.
Buchholz
Tina
T
Department of Obstetrics and Gynecology - Grosshadern, Klinikum der Universität München, Germany.
Lohse
Peter
P
Kosian
Elke
E
Thaler
Christian J
CJ
D000026:Abortion, Habitual / Q000235:genetics* / Q000503:physiopathology; D000328:Adult; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008875:Middle Aged; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011247:Pregnancy; D044139:Receptor, Angiotensin, Type 2 / Q000235:genetics*; D020080:Tandem Repeat Sequences / Q000235:genetics; D014661:Vasoconstriction / Q000235:genetics / Q000502:physiology
D044139:Receptor, Angiotensin, Type 2; D004247:DNA; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III