title: Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman's syndrome.
abstract: A 69-year-old woman was referred to our department for evaluation of hypokalemia, which had been treated by oral potassium for more than ten years. She complained of headache, knee joint pain, sleeplessness and paresthesia in extremities and, most prominently, depression. Laboratory data suggested Gitelman's syndrome, which is caused by mutations in the gene encoding the thiazide-sensitive Na-Cl cotransporter. Direct sequencing of the gene in this patient revealed homozygous mutation R964Q in exon 25. Intravenous supplement of MgSO4 dramatically improved both the depression and the paresthesia, suggesting that hypomagnesemia played a role in the clinical manifestations.
authors.affiliation: Third Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705.
authors.forename: Mayumi
authors.initials: M
authors.lastname: Enya
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kanoh
authors.forename: Tomoatsu
authors.initials: T
authors.lastname: Mune
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Ishizawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sarui
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Takeda
authors.forename: Keigo
authors.initials: K
authors.lastname: Yasuda
authors.forename: Minoru
authors.initials: M
authors.lastname: Yasujima
authors.forename: Shoji
authors.initials: S
authors.lastname: Tsutaya
authors.forename: Jun
authors.initials: J
authors.lastname: Takeda
mesh_terms: D000368:Aged; D000471:Alkalosis / Q000175:diagnosis; D001477:Bartter Syndrome / Q000175:diagnosis*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis; D006996:Hypocalcemia / Q000175:diagnosis; D007008:Hypokalemia / Q000175:diagnosis; D007262:Infusions, Intravenous; D008275:Magnesium Deficiency / Q000175:diagnosis / Q000517:prevention & control*; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D010292:Paresthesia / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D008278:Magnesium Sulfate