title: Co-secretion of aldosterone and cortisol by an adrenocortical carcinoma.
abstract: We report a rare case of adrenocortical carcinoma. A 26-year-old woman presented with hypokalemia and hypertension due to hyperaldosteronism. She had no signs of Cushing's syndrome. Endocrinological data showed excess of aldosterone production and nonsupressible cortisol production on 2 mg of dexamethasone. Magnetic resonance imaging showed left adrenal tumor. Transabdominal left adrenalectomy was performed and histopathological diagnosis was adrenocortical carcinoma. Her blood pressure and hypokalemia returned to normal after adrenalectomy. There is no recurrence after 36 months. We want to emphasis the importance of adrenal tests before the operation even if there are no signs of excess cortisol production.
authors.affiliation: Division of Endocrinology, Metabolism and Nutrition, Departmant of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey. neslihandr@hotmail.com
authors.forename: Neslihan
authors.initials: N
authors.lastname: Kurtulmus
authors.forename: Sema
authors.initials: S
authors.lastname: Yarman
authors.forename: Halil
authors.initials: H
authors.lastname: Azizlerli
authors.forename: Yersu
authors.initials: Y
authors.lastname: Kapran
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D018268:Adrenocortical Carcinoma / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D006929:Hyperaldosteronism / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D007008:Hypokalemia / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D013148:Spironolactone / Q000627:therapeutic use
chemical_list: D004232:Diuretics; D013148:Spironolactone; D000450:Aldosterone; D006854:Hydrocortisone