title: Secondary ion images of the developing rat brain.
abstract: Secondary ion images were obtained from sections of rat brain over a 21 day postnatal period, using the intensity of m/z 184, phosphocholine. When compared with corresponding optical images of similar, but stained sections from the same animal, the secondary ion images appear to reflect less developed brains. During development, myelination occurs after axon extension. Apparently, myelination obscures the source of secondary m/z 184, phosphatidylcholine, from the analyzing ion probe; absenting myelination, secondary ion images show no physiological features.
authors.affiliation: Chemical Sciences Division, Oak Ridge National Laboratory, Tennessee 37831-6365, USA. toddpj@ornl.gov
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Todd
authors.forename: John M
authors.initials: JM
authors.lastname: McMahon
authors.forename: Carl A
authors.initials: CA
authors.lastname: McCandlish
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D010767:Phosphorylcholine / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018629:Spectrometry, Mass, Secondary Ion / Q000379:methods*
chemical_list: D010767:Phosphorylcholine