title: [Usefulness of urinary trypsinogen-2 dipstick test for diagnosis of acute pancreatitis].
abstract: OBJECTIVE
  The clinical usefulness of urinary trypsinogen-2 dipstick test is still in controversy. We evaluated the usefulness of urinary trypsinogen-2 dipstick test in patients with acute pancreatitis.
  
  
  METHODS
  Urinary trypsinogen-2 dipstick test was prospectively performed in 50 patients with acute pancreatitis, 50 patients with non-pancreatic abdominal pain, and 50 healthy controls.
  
  
  RESULTS
  On admission, urinary trypsinogen-2 dipstick test was positive in 36 of 50 patients with acute pancreatitis (sensitivity, 72%) and in 4 of 50 patients with non-pancreatic abdominal pain (specificity, 92%). On the other hand, it was all negative in controls. The sensitivity and specificity of serum lipase were 78% and 94%, respectively. At 24 hours after admission, the positive rate of urinary trypsinogen-2 dipstick test rose from 72% to 94% (p=0.02). The results of urinary trypsinogen-2 dipstick test was positive in 14 of 15 patients with severe pancreatitis and 22 of 35 patients with mild pancreatitis according to the criteria by Atlanta International Symposium, 1992.
  
  
  CONCLUSIONS
  Urinary trypsinogen-2 dipstick test is comparable to serum lipase in diagnosing acute pancreatitis. Delayed measurement and severe pancreatitis are more likely to yield positive results with urinary trypsinogen-2 dipstick test. Thus, we suggest that the cut-off value of urinary trypsinogen-2 dipstick test should be lowered to increase its sensitivity.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Seoung Joon
authors.initials: SJ
authors.lastname: Hwang
authors.forename: Jun Pyo
authors.initials: JP
authors.lastname: Chung
authors.forename: Young Gyun
authors.initials: YG
authors.lastname: Kim
authors.forename: Dae Hoon
authors.initials: DH
authors.lastname: Song
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Seung Seok
authors.initials: SS
authors.lastname: Baek
authors.forename: Do Yun
authors.initials: DY
authors.lastname: Kim
authors.forename: Dok Yong
authors.initials: DY
authors.lastname: Lee
authors.forename: Yon Soo
authors.initials: YS
authors.lastname: Jeong
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Ji
authors.forename: Se Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Si Young
authors.initials: SY
authors.lastname: Song
authors.forename: Kwan Sik
authors.initials: KS
authors.lastname: Lee
authors.forename: Jae Bock
authors.initials: JB
authors.lastname: Chung
authors.forename: Sang In
authors.initials: SI
authors.lastname: Lee
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Kang
authors.forename: Jun Seog
authors.initials: JS
authors.lastname: Park
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Cho
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis*; D011934:Reagent Strips; D012680:Sensitivity and Specificity; D014362:Trypsinogen / Q000652:urine*
chemical_list: D015415:Biomarkers; D011934:Reagent Strips; D014362:Trypsinogen; D008049:Lipase