title: Childhood-onset schizophrenia and tryptophan hydroxylase gene polymorphism.
abstract: We explored the relationship between the tryptophan hydroxylase gene polymorphism and susceptibility to childhood-onset schizophrenia in a Japanese sample. Subjects were 51 Japanese patients who met DSM-IV criteria for schizophrenia before age 16 and 148 Japanese healthy controls. DNA was extracted from whole blood and genotyping was performed by PCR-RFLP using Nhe I. The frequency of the A allele was relatively higher in patients with childhood-onset schizophrenia than in controls (odds ratio, OR = 1.47, 95% CI = 0.97-2.37, P = 0.097). There was a nearly doubling of the risk for childhood-onset schizophrenia associated with the AA genotype compared to other genotype groups; OR = 1.97, 95% CI = 0.91-4.22, P = 0.058.
authors.affiliation: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, Shizuoka 431-3192, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Sekizawa
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Iwata
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Atsuko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Katsuaki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Yoshimoto
authors.initials: Y
authors.lastname: Sekine
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Takei
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D017720:Molecular Epidemiology; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D014365:Tryptophan Hydroxylase / Q000235:genetics*
chemical_list: D014365:Tryptophan Hydroxylase