title: Punctate palmoplantar keratoderma with pigmentary lesions on the dorsa of feet and ankles: successful treatment with a combination of low-dose oral etretinate and topical calcipotriol.
abstract: We describe a patient with typical keratotic lesions of punctate palmoplantar keratoderma on the hands and feet and unique pigmentary lesions on the dorsa of the feet and ankles. A combination of low-dose oral etretinate (10 mg/day) and calcipotriol ointment 0.005% resulted in a complete regression, whereas pigmentary lesions on the dorsa of the feet and ankles did not change during the treatment.
authors.affiliation: Department of Dermatology, National Defence Medical College, Namiki, Tokorozawa, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Horikoshi
authors.forename: Kei
authors.initials: K
authors.lastname: Kuroda
authors.forename: Shingo
authors.initials: S
authors.lastname: Tajima
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000368:Aged; D000842:Ankle; D002117:Calcitriol / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005050:Etretinate / Q000008:administration & dosage*; D005528:Foot; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007641:Keratolytic Agents / Q000008:administration & dosage*; D008297:Male; D010859:Pigmentation Disorders / Q000150:complications*
chemical_list: D003879:Dermatologic Agents; D007641:Keratolytic Agents; C055085:calcipotriene; D005050:Etretinate; D002117:Calcitriol