title: [Mixed cryoglobulinemia with monoclonal IgA and biclonal IgM during hepatitis C virus infection].
abstract: Cryoglobulins are immunoglobulins that precipitate at low temperature and dissolve when warmed. According to Brouet, their classification relies upon the immunochemical study: type I comprises monoclonal immunoglobulins (IGG), when types II and III include both monoclonal and polyclonal components. During C hepatitis, the presence of a cryoglobulin, essentially made of mixed G-IGG and M-IGG, is a common feature with a prevalence of 40 to 80%. The authors report a case of a 63-year patient who presented with a vascular purpura and a peripheral polyneuropathy in a context of C hepatitis infection. The cryoglobulin found was composed of a monoclonal kappa A-IgG associated with a biclonal kappa and lambda M-IgG. No decrease of normal IgGs was found. This type of cryoglobulin does not belong to Brouet's classification, and argues for a new and more pertinent classification to be proposed.
authors.affiliation: Service de Médicine interne A, Hôpital Ibn-Sina, CHU, Rabat, Morocco.
authors.forename: S
authors.initials: S
authors.lastname: Abdi
authors.forename: M
authors.initials: M
authors.lastname: Bahji
authors.forename: L
authors.initials: L
authors.lastname: Essaadouni
authors.forename: N  Benkirane
authors.initials: N
authors.lastname: Agoumi
authors.forename: M
authors.initials: M
authors.lastname: Adnaoui
authors.forename: Z Mezalek
authors.initials: ZM
authors.lastname: Tazi
authors.forename: A
authors.initials: A
authors.lastname: Maaouni
mesh_terms: D000911:Antibodies, Monoclonal / Q000097:blood; D003449:Cryoglobulinemia / Q000097:blood / Q000150:complications*; D006526:Hepatitis C / Q000097:blood / Q000150:complications*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007075:Immunoglobulin M