Thalidomide sensory neurotoxicity: a clinical and neurophysiologic study.
The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.
Cavaletti
G
G
Dipartimento di Neuroscienze e Tecnologie Biomediche, Università di Milano Bicocca, Monza, Italia. guido.cavaletti@unimib.it
Beronio
A
A
Reni
L
L
Ghiglione
E
E
Schenone
A
A
Briani
C
C
Zara
G
G
Cocito
D
D
Isoardo
G
G
Ciaramitaro
P
P
Plasmati
R
R
Pastorelli
F
F
Frigo
M
M
Piatti
M
M
Carpo
M
M
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*; D013792:Thalidomide / Q000008:administration & dosage / Q000506:poisoning*
D013792:Thalidomide