title: Solution-phase reductive cyclization of 2-quinoxalinol analogs: systematic study of parallel synthesis.
abstract: 1,5-Difluoro-2,4-dinitrobenzene starting material was treated via primary and/or secondary substitution with a variety of amino acids or amines and the aromatic m-dinitro groups were then reductively cyclized provide the 2-quinoxalinol analogs. The conditions for 1,5-dialkylamino-2,4-dinitrobenzene reduction have been systematically studied and optimized in solution. Three effective methods are described for the high-throughout generation of 2-quinoxalinol analogs.
authors.affiliation: Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, PR China.
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Wu
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhan-Guo
authors.initials: ZG
authors.lastname: Wang
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.forename: Suo-De
authors.initials: SD
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
mesh_terms: D001671:Biochemistry / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D011810:Quinoxalines / Q000138:chemical synthesis*; D012996:Solutions
chemical_list: D011810:Quinoxalines; D012996:Solutions