Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis.
The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.
Zeidner
N S
NS
Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, P.O. Box 2087, Rampart Rd., Foothill Campus, Fort Collins, CO 80522, USA. naz2@cdc.gov
Brandt
K S
KS
Dadey
E
E
Dolan
M C
MC
Happ
C
C
Piesman
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001733:Bites and Stings / Q000150:complications*; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations; D004318:Doxycycline / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D007279:Injections, Subcutaneous; D008193:Lyme Disease / Q000209:etiology* / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D013987:Ticks
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004318:Doxycycline