title: MyHits: a new interactive resource for protein annotation and domain identification.
abstract: The MyHits web server (http://myhits.isb-sib.ch) is a new integrated service dedicated to the annotation of protein sequences and to the analysis of their domains and signatures. Guest users can use the system anonymously, with full access to (i) standard bioinformatics programs (e.g. PSI-BLAST, ClustalW, T-Coffee, Jalview); (ii) a large number of protein sequence databases, including standard (Swiss-Prot, TrEMBL) and locally developed databases (splice variants); (iii) databases of protein motifs (Prosite, Interpro); (iv) a precomputed list of matches ('hits') between the sequence and motif databases. All databases are updated on a weekly basis and the hit list is kept up to date incrementally. The MyHits server also includes a new collection of tools to generate graphical representations of pairwise and multiple sequence alignments including their annotated features. Free registration enables users to upload their own sequences and motifs to private databases. These are then made available through the same web interface and the same set of analytical tools. Registered users can manage their own sequences and annotations using only web tools and freeze their data in their private database for publication purposes.
authors.affiliation: Swiss Institute of Bioinformatics, CH-1066 Epalinges/Lausanne, Switzerland. Marco.Pagni@isb-sib.ch
authors.forename: Marco
authors.initials: M
authors.lastname: Pagni
authors.forename: Vassilios
authors.initials: V
authors.lastname: Ioannidis
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cerutti
authors.forename: Monique
authors.initials: M
authors.lastname: Zahn-Zabal
authors.forename: C Victor
authors.initials: CV
authors.lastname: Jongeneel
authors.forename: Laurent
authors.initials: L
authors.lastname: Falquet
mesh_terms: D003196:Computer Graphics; D030562:Databases, Protein; D020407:Internet; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D020539:Sequence Analysis, Protein; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface