Papaverine, an opium alkaloid influences hepatic and pulmonary glutathione S-transferase activity and glutathione content in rats.
The present study evaluates the effect of oral administration of papaverine at differential dosing regimens (100 mg/kg bw and 200 mg/kg bw) on the hepatic and pulmonary glutathione S-transferase (GST) activity and glutathione content (GSH) in male Wistar rats. Papaverine treatment caused a pronounced increase in GST activity and GSH content at the higher dosing level in the rat liver and lung. We conclude that papaverine, can possibly act as a chemopreventive agent against chemical carcinogenesis.
Aneja
Ritu
R
Department of Chemistry, University of Delhi, Delhi, India.
Sharma
Archana
A
Talwar
Anita
A
Dass
Sujata K
SK
Chandra
Ramesh
R
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D010208:Papaverine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D016588:Anticarcinogenic Agents; D010208:Papaverine; D005982:Glutathione Transferase; D005978:Glutathione