title: Differential efficacy of clarithromycin in lung versus thigh infection models.
abstract: BACKGROUND
  Differences in clarithromycin disposition and the resulting changes in bacterial density were studied using mouse lung and thigh infection models.
  
  
  METHODS
  Clarithromycin activity was evaluated against seven Streptococcus pneumoniae isolates with efflux-mediated resistance in both murine lung and thigh infection models. Intrapulmonary disposition of clarithromycin was also studied.
  
  
  RESULTS
  Consistent bacterial kill was observed in the lung model, whereas no drug effect was observed in the thigh model.
  
  
  CONCLUSIONS
  These differences in bacterial density were supported by high concentrations observed in epithelial lining fluid as compared to serum.
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, Conn., USA.
authors.forename: Dana
authors.initials: D
authors.lastname: Maglio
authors.forename: Blair
authors.initials: B
authors.lastname: Capitano
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Banevicius
authors.forename: Qiuming
authors.initials: Q
authors.lastname: Geng
authors.forename: Charles H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017291:Clarithromycin / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004195:Disease Models, Animal; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D008168:Lung / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D018410:Pneumonia, Bacterial / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification; D013848:Thigh / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D017291:Clarithromycin