Age-associated changes in hormonal function of the pancreas and regulation of blood glucose in monkeys.
Age-associated changes in the concentrations of glucose, insulin, and DHEAS in peripheral blood plasma of female rhesus macaques were studied in intact animals and in response to a standard dose of glucose and insulin. Basal levels of insulin and glucose increased, insulin sensitivity and glucose tolerance decreased, and pancreatic reaction to glucose load was impaired in old monkeys. Insulin level positively correlated with glucose concentration, body weight, and abdomen circumference and negatively correlated with DHEAS level.
Goncharova
N D
ND
State Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi.
Vengerin
A A
AA
Oganyan
T E
TE
Lapin
B A
BA
D000375:Aging / Q000097:blood* / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D008253:Macaca mulatta / Q000097:blood / Q000502:physiology; D010179:Pancreas / Q000187:drug effects / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D019314:Dehydroepiandrosterone Sulfate