Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032.
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.
Riedlinger
Julia
J
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
Reicke
Andreas
A
Zähner
Hans
H
Krismer
Bernhard
B
Bull
Alan T
AT
Maldonado
Luis A
LA
Ward
Alan C
AC
Goodfellow
Michael
M
Bister
Bojan
B
Bischoff
Daniel
D
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D010129:4-Aminobenzoic Acid / Q000037:antagonists & inhibitors* / Q000378:metabolism; D039903:Actinobacteria / Q000737:chemistry / Q000378:metabolism*; D024322:Amino Acids, Aromatic / Q000037:antagonists & inhibitors / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D018942:Macrolides / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010802:Phylogeny
D024322:Amino Acids, Aromatic; D000900:Anti-Bacterial Agents; D018942:Macrolides; D010129:4-Aminobenzoic Acid