[Adipocytokines and metabolic syndrome--molecular mechanism and clinical implication].
Recent progress in adipocyte-biology shows that adipocytes are not merely fat-storing cells but that they secrete a variety of hormones, cytekines, growth factors and other bioactive substabces, conceptualized as adipocytokines. These include plasminogen activator inhibitor 1(PAI-1), tumor necrosis factor(TNF-alpha), leptin and adiponectin. Dysregulated productions of these adipocytekines participate in the pathogenesis of obesity-associated metabolic syndrome such as insulin resistance, type 2 diabetes, hyperlipidemia, and vascular diseases. Increased productions of PAI-1 and TNF-alpha from accumulated fat contribute to the formation of thrombosis and insulin resistance in obesity, respectively. Lack of leptin causes metabolic syndrome. Adiponectin exerts insulin-sensitizing and anti-atherogenic effects, hence decrease of plasma adiponectin is causative for insulin resistance and atherosclerosis in obesity.
Matsuda
Morihiro
M
Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience and Graduate School of Medicine, Osaka University.
Shimomura
Iichiro
I
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000503:physiopathology*
D016207:Cytokines