Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.
Rhesus and human cytomegalovirus (RhCMV and HCMV, respectively) exhibit comparable inhibition by benzimidazole nucleosides, including 2,5,6-trichloro-(1-beta-d-ribofuranosyl)benzimidazole (TCRB), and pyrrolo[2,3-d]pyrimidines. The two HCMV protein targets of TCRB, UL89 and UL56, are highly conserved with their RhCMV homologues. These data indicate that infection of rhesus macaques with RhCMV represents a useful model to test novel anti-HCMV drugs.
North
Thomas W
TW
Center for Comparative Medicine, University of California-Davis, Davis, CA 95616, USA. twnorth@ucdavis.edu
Sequar
Getachew
G
Townsend
Leroy B
LB
Drach
John C
JC
Barry
Peter A
PA
D000595:Amino Acid Sequence; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002478:Cells, Cultured; D017124:Conserved Sequence; D003587:Cytomegalovirus / Q000187:drug effects*; D005347:Fibroblasts; D006801:Humans; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D009705:Nucleosides / Q000494:pharmacology*; D012689:Sequence Homology, Nucleic Acid; D010948:Viral Plaque Assay
D000998:Antiviral Agents; D001562:Benzimidazoles; D009705:Nucleosides