[Effect of fluorine, selenium and cadmium on anti-oxidase and microelements in rat's body].
OBJECTIVE
To study the effect of fluorine, selenium and cadmium on lipid peroxide(LPO), the activity of glutathione peroxidase (GSH-Px) and microelements such as cadmium, selenium and zinc in rats.


METHODS
Measurement of the contents of LPO, GSH-Px and microelements such as cadmium, selenium and zinc in SD rats after killing that have drunk water containing fluorine, selenium and cadmium eight-week ago.


RESULTS
The contents of GSH-Px in the serum, liver and kidney of rats that were contaminated with fluorine, selenium and cadmium respectively remarkably reduced and the content of LPO noticeably increased in comparison with those of rats without being contaminated. The contents of GSH-Px noticeably increased and LPO remarkably reduced in those contaminated with the combination of any two of the three elements when compared with those in the rats contaminated with any one element of them, while the contents of GSH-Px in those contaminated with the combination of the three elements increased even more. Excessive selenium or cadmium led to the increase of selenium content in kidney and cadmium content in liver by several times. Excessive fluorine or cadmium gave rise to the lack of selenium and zinc. Selenium brought out universal increase of zinc in liver and kidney. The combination of fluorine and selenium or the combination of cadmium and selenium or that of fluorine, selenium and cadmium produced remarkable decrease of the accumulation of selenium in kidney and cadmium in liver. They also lowed the loss of zinc caused by fluorine or cadmium.


CONCLUSIONS
Excessive fluorine, selenium or cadmium could inhabit the activity of GSH-Px in rats, which could diminish the antioxidation ability of the body. But when two or three of the chemical elements coexisted, they reduced the inhabitation of each of them on the activity of GSH-Px and in the meantime decreased the accumulation of cadmium and selenium and diminished the loss of zinc caused by fluorine and cadmium.
Mou
Suhua
S
Medicine in Medical School of Hubei Institute for Nationalities, Enshi 445000, China.
Qin
Si
S
Hu
Qituo
Q
Duan
Xianyu
X
D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D004336:Drug Antagonism; D005461:Fluorine / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000378:metabolism / Q000633:toxicity*; D015032:Zinc / Q000378:metabolism
D008054:Lipid Peroxides; D002104:Cadmium; D005461:Fluorine; D005979:Glutathione Peroxidase; D012643:Selenium; D015032:Zinc