title: Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study.
abstract: OBJECTIVE
  This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia.
  
  
  METHODS
  Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent (31)P MRS.
  
  
  RESULTS
  The phosphocreatine/total phosphorus and phosphocreatine/total ATP ratios in both basal ganglia were significantly lower in patients.
  
  
  CONCLUSIONS
  Schizophrenia patients showed features of increased metabolism in the basal ganglia consistent with impaired activity of the frontostriatal pathways.
authors.affiliation: Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, 560 029 Bangalore, India.
authors.forename: B N
authors.initials: BN
authors.lastname: Gangadhar
authors.forename: P N
authors.initials: PN
authors.lastname: Jayakumar
authors.forename: D K
authors.initials: DK
authors.lastname: Subbakrishna
authors.forename: N
authors.initials: N
authors.lastname: Janakiramaiah
authors.forename: M S
authors.initials: MS
authors.lastname: Keshavan
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage; D001479:Basal Ganglia / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009434:Neural Pathways / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D010759:Phosphorus Isotopes; D012559:Schizophrenia / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate