Effects of chronic lung inflammation on tryptophan metabolism in piglets.
A fundamental question in animal nutrition is the amino acid requirement induced by inflammation and immune response. The aim of the present experiment was to study the effect of chronic lung inflammation induced by injection of complete Freund adjuvant on amino acid metabolism in pigs. For 10 days, we compared plasma haptoglobine and amino acid concentrations of piglets with chronic lung inflammation (CFA) with those of pair-fed littermate healthy pigs (CONTROL). Tryptophan was the only amino acid for which the plasma concentration was continously decreasing and did not reach the control level at the end of the experimental period. We suggested that an increase in tryptophan catabolism under indoleamine 2, 3 dioxygenase activation and/or tryptophan incorporation into acute phase protein could explained the decrease in plasma tryptophan concentration in pigs suffuring from chronic lung inflammation.
Melchior
Delphine
D
INRA Unité Mixte de Recherches sur le Veau et le Porc Domaine de la prise 35590 St-Gilles, France. melchior@st-gilles.rennes.inra.fr
Le Floc'h
Nathalie
N
Sève
Bernard
B
D000818:Animals; D002908:Chronic Disease; D005620:Freund's Adjuvant / Q000008:administration & dosage; D007737:Kynurenine / Q000097:blood; D011014:Pneumonia / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D034421:Sus scrofa; D013553:Swine Diseases / Q000209:etiology / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*
D007737:Kynurenine; D014364:Tryptophan; D005620:Freund's Adjuvant