Do folic acid and thiocyanate have a preventive effect on exogenously induced disturbances of embryonic cranial development?
The preventive influence of folic acid and thiocyanate on procarbazine-induced disturbances of embryonic cranial development was investigated on experimental animals. Low dosages of folic acid or thiocyanate demonstrated no prophylactic effect. When thiocyanate was administered alone, an increased cleft rate was unexpectedly found for the secondary palate. The combined application of folic acid and thiocyanate showed a cleft-prophylactic effect in the secondary palate in addition to growth protection in the primary palate. It can be assumed that thiocyanate has a positive effect on chondral and osseous growth of the palate during the post-sensitive phase of embryogenesis, while in the sensitive phase, it can function as a carrier for teratogenous and toxic substances.
Weingärtner
J
J
Institute for Anatomy, Ernst Moritz Arndt University Greifswald, F.-Loeffler-Str. 23c, 17487 Greifswald, Germany. weingaer@uni-greifswald.de
Martens
A
A
Bienengräber
V
V
Fanghänel
J
J
Kundt
G
G
D000818:Animals; D002972:Cleft Palate / Q000139:chemically induced* / Q000196:embryology / Q000517:prevention & control*; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006397:Hematinics / Q000627:therapeutic use*; D010159:Palate / Q000196:embryology; D011344:Procarbazine; D051381:Rats; D011917:Rats, Inbred Lew; D013723:Teratogens; D013861:Thiocyanates / Q000627:therapeutic use* / Q000633:toxicity
D006397:Hematinics; D013723:Teratogens; D013861:Thiocyanates; D011344:Procarbazine; D005492:Folic Acid; C031760:thiocyanate