Regulation of the epithelial Ca2+ channels TRPV5 and TRPV6 by 1alpha,25-dihydroxy Vitamin D3 and dietary Ca2+.
Active, transepithelial Ca(2+) transport is a pivotal process in the regulation of Ca(2+) homeostasis and consists of three sequential steps: apical Ca(2+) influx, diffusion towards the basolateral membrane and subsequent extrusion into the blood compartment. TRPV5 and TRPV6 (renamed after ECaC1 and ECaC2/CaT1, respectively) constitute the rate-limiting influx step of transepithelial Ca(2+) transport and these highly selective Ca(2+) channels are controlled by several factors. This review focuses on the regulation of TRPV5 and TRPV6 abundance and/or activity by 1alpha,25-dihydroxyVitamin D(3) (1alpha,25(OH)(2)D(3)), dietary Ca(2+) and the auxiliary protein pair S100A10/annexin 2. Finally, the implications for our understanding of transcellular Ca(2+) transport will be discussed.
van de Graaf
Stan F J
SF
Department of Physiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
Boullart
Inge
I
Hoenderop
Joost G J
JG
Bindels
René J M
RJ
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000008:administration & dosage*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D004032:Diet; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D050916:TRPV Cation Channels
D015220:Calcium Channels; D050916:TRPV Cation Channels; C492239:TRPV5 protein, human; C120776:TRPV6 channel; C492240:Trpv5 protein, mouse; D002117:Calcitriol; D002118:Calcium