Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity.
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type hypersensitivity and rejection of corneal transplants. Regulating the function of VEGFR-3 may therefore be a mechanism for modulating adaptive immunity in the periphery.
Chen
Lu
L
Laboratory of Immunology, Schepens Eye Research Institute and the Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, 20 Staniford Street, Boston, Massachusetts, USA.
Hamrah
Pedram
P
Cursiefen
Claus
C
Zhang
Qiang
Q
Pytowski
Bronislaw
B
Streilein
J Wayne
JW
Dana
M Reza
MR
D000818:Animals; D016039:Corneal Transplantation / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology; D005434:Flow Cytometry; D005786:Gene Expression Regulation / Q000276:immunology*; D006023:Glycoproteins; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007634:Keratitis / Q000276:immunology*; D042583:Lymphangiogenesis / Q000276:immunology*; D026901:Membrane Transport Proteins; D051379:Mice; D008856:Microscopy, Fluorescence; D023421:Models, Animal; D015398:Signal Transduction / Q000276:immunology*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism; D040321:Vascular Endothelial Growth Factor Receptor-3 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D033921:Vesicular Transport Proteins
D006023:Glycoproteins; D026901:Membrane Transport Proteins; D042582:Vascular Endothelial Growth Factor C; D040321:Vascular Endothelial Growth Factor Receptor-3; D033921:Vesicular Transport Proteins; C119248:LYVE1 protein, human; C492273:LYVE1 protein, mouse