title: Estrogen receptor ligands. Part 8: Dihydrobenzoxathiin SERAMs with heteroatom-substituted side chains.
abstract: A series of benzoxathiin SERAMs with heteroatom-substituted amine side chains was prepared. Minor modifications in the side chain resulted in significant effects on biological activity, especially in uterine tissue.
authors.affiliation: Merck Research Laboratories, Medicinal Chemistry, RY800-B116, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Blizzard
authors.forename: Frank
authors.initials: F
authors.lastname: DiNinno
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Morgan
authors.forename: Jane Y
authors.initials: JY
authors.lastname: Wu
authors.forename: Helen Y
authors.initials: HY
authors.lastname: Chen
authors.forename: Seongkon
authors.initials: S
authors.lastname: Kim
authors.forename: Wanda
authors.initials: W
authors.lastname: Chan
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Birzin
authors.forename: Yi Tien
authors.initials: YT
authors.lastname: Yang
authors.forename: Lee-Yuh
authors.initials: LY
authors.lastname: Pai
authors.forename: Zhoupeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Edward C
authors.initials: EC
authors.lastname: Hayes
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: DaSilva
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Susan P
authors.initials: SP
authors.lastname: Rohrer
authors.forename: James M
authors.initials: JM
authors.lastname: Schaeffer
authors.forename: Milton L
authors.initials: ML
authors.lastname: Hammond
mesh_terms: D000818:Animals; D005260:Female; D007700:Kinetics; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D011960:Receptors, Estrogen / Q000378:metabolism*; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
chemical_list: D008024:Ligands; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators