PDGF and cardiovascular disease.
Platelet-derived growth factor (PDGF) was identified in a search for serum factors that stimulate smooth muscle cell (SMC) proliferation. During the development of lesions of atherosclerosis that can ultimately lead to vessel occlusion, SMC are stimulated by inflammatory factors to migrate from their normal location in the media. They accumulate within the forming lesion where they contribute to lesion expansion by proliferation and deposition of extracellular matrix. Different genetic manipulations in vascular cells combined with various inhibitory strategies have provided strong evidence for PDGF playing a prominent role in the migration of SMC into the neointima following acute injury and in atherosclerosis. Other activities of PDGF identified in vivo suggest additional functions for PDGF in the pathogenesis of cardiovascular disease.
Raines
Elaine W
EW
Department of Pathology, Harborview Medical Center, University of Washington, Box 359675, 325 9th Avenue, Seattle, WA 98104, USA. ewraines@u.washington.edu
D000818:Animals; D001158:Arteries / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D005786:Gene Expression Regulation; D051379:Mice; D008954:Models, Biological; D032389:Myocytes, Smooth Muscle / Q000166:cytology; D010766:Phosphorylation; D010974:Platelet Aggregation; D010982:Platelet-Derived Growth Factor / Q000378:metabolism / Q000502:physiology*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism; D015398:Signal Transduction; D013314:Stress, Mechanical
D010982:Platelet-Derived Growth Factor; D020796:Receptor, Platelet-Derived Growth Factor alpha