Pars plana vitrectomy for vitreous opacity associated with ocular sarcoidosis resistant to medical treatment.
OBJECTIVE
To examine the results of pars plana vitrectomy for nonclearing vitreous opacities associated with ocular sarcoidosis that is resistant to corticosteroid treatment.


METHODS
Eight consecutive patients (11 eyes) with vitreous opacities and uveitis associated with sarcoidosis were studied. All patients were resistant to or intolerant of corticosteroid therapy. All eyes underwent pars plana vitrectomy, followed by evaluation of visual acuity and recording of the grade of inflammation and complications.


RESULTS
Seven eyes had gained two or more lines of Snellen visual acuity six months postoperatively; visual acuity remained unchanged in the other four eyes. Vitreous inflammation was reduced in all cases. Severe postoperative inflammation did not recur in any eyes. Five eyes developed visually significant cataracts and underwent cataract extraction and intraocular lens insertion within 8-30 months. Based on slit-lamp biomicroscopy and fluorescein angiography, preoperative cystoid macular edema in five eyes resolved or improved within six months after vitrectomy. Postoperative complications included elevated intraocular pressure in three eyes, cataract formation in six eyes, epiretinal membrane formation in one eye, and choroidal neovascularization in one eye. None of the patients developed cystoid macular edema postoperatively. Only three patients received systemic corticosteroids after surgery. At the final visit, only one patient required systemic corticosteroid therapy.


CONCLUSIONS
Pars plana vitrectomy appears to have beneficial effects on restoring vision, stabilizing vitreous inflammation, and reducing systemic corticosteroid requirements in eyes with thick vitreous opacities associated with sarcoidosis that is resistant to medical treatment.
Ieki
Yoshiaki
Y
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. kiryu@kuhp.kyoto-u.ac.jp
Kiryu
Junichi
J
Kita
Mihori
M
Tanabe
Teruyo
T
Tsujikawa
Akitaka
A
Yamashiro
Kenji
K
Miyamoto
Noriko
N
Miura
Shinji
S
Honda
Yoshihito
Y
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004351:Drug Resistance; D005128:Eye Diseases / Q000209:etiology / Q000601:surgery*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D014605:Uveitis / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D014792:Visual Acuity; D014821:Vitrectomy; D014822:Vitreous Body / Q000473:pathology / Q000601:surgery*
D005938:Glucocorticoids