Concomitant coronary and multiple arch vessel stenoses in patients treated with external beam radiation: pathophysiological basis and endovascular treatment.
External beam radiation-induced stenoses isolated to the coronary arteries or peripheral vessels have been previously described. We report for the first time the clinical presentation of two patients with concomitant coronary artery and multiple arch vessel disease following external beam radiation of the chest. We review the pathophysiology, discuss the treatment options and describe the percutaneous treatment of coronary, carotid, subclavian, and axillary stenoses related to this rare but likely underdiagnosed disorder.
Cavendish
Jeffrey J
JJ
Division of Cardiology, University of California, San Diego, California, USA.
Berman
Brett J
BJ
Schnyder
Guido
G
Kerber
Charles
C
Mahmud
Ehtisham
E
Turi
Zoltan G
ZG
Blanchard
Daniel
D
Tsimikas
Sotirios
S
D000368:Aged; D000792:Angiography; D001918:Brachytherapy / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002339:Carotid Arteries / Q000528:radiation effects*; D016893:Carotid Stenosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D023921:Coronary Stenosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D003331:Coronary Vessels / Q000293:injuries / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy*; D008875:Middle Aged