[Application of ricin-immunotoxin mediated T cell depletion to allogeneic hematopoietic stem cell transplantation].
This study was aimed to investigate the clinical outcome of ricin-immunotoxin mediated T cell partially depleted HLA/MLC mismatched allogeneic hematopoietic stem cell transplantation. 13 patients with hematological malignancies were treated by ricin-immunotoxin mediated T cell partially depleted allogeneic hematopoietic stem cell transplantations from HLA/MLC mismatched donors, including 6 cases of CML in CP(1), 1 case of ALL in CR(1), 1 case of ALL in CR(2), 1 case of ALL in relapse, 2 cases of AML in CR(1), 1 case of AML in CR(2), 1 case of MDS-RAEBT-AML (M(4)) in CR(1). The results showed that 8 cases were engrafted successfully, 2 cases of them developed grade II acute GVHD and 2 cases developed grade III-IV acute GVHD. Within following-up of 8 - 90 months, 2 patients who experienced grade III-IV acute GVHD died early after transplantation; 1 patient died of late onset of infection; the other 5 patients survived free from diseases. After failure at first infusion, 4 patients were given reinfusion of peripheral blood hematopoietic stem cells from the same donor. 3 out of 4 cases failed to engraft and only one patient got engraftment but died of related complications of transplantation. One patient was performed a second transplantation from a syngeneic donor and survive free of disease until now. In conclusion, T cell partially depleted HLA/MLC mismatched allogeneic hematopoietic stem cell transplantation by ricin-immunotoxin decreases the occurrence of severe acute GVHD but with high risk of rejection, which clinical outcome still needs further evaluation.
Lai
Yue-Yun
YY
Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China. laiyueyun1008@yahoo.com.cn
Guo
Nai-Lan
NL
Huang
Xiao-Jun
XJ
Xu
Lan-Ping
LP
Chen
Huan
H
Wang
Su-Qin
SQ
Zheng
Hai-Yin
HY
Li
Yan
Y
Shen
Bei-Fen
BF
Lu
Dao-Pei
DP
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006086:Graft vs Host Disease / Q000453:epidemiology; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology*; D008212:Lymphocyte Depletion / Q000379:methods*; D008297:Male; D012276:Ricin / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects*; D014184:Transplantation, Homologous
D000922:Immunotoxins; D012276:Ricin