[A case of MPO-ANCA-related vasculitis after asbestos exposure with progression of a renal lesion after improvement of interstitial pneumonia].
A 72-year-old woman was admitted complaining of productive cough. She had worked for an asbestos factory for twenty years. She was positive for MPO-ANCA. The chest HRCT showed interstitial pneumonia without any UIP pattern. A specimen obtained by video-assisted thoracoscopic lung biopsy revealed chronic interstitial pneumonia associated with an asbestos body. Although the interstitial pneumonia improved after the administration of a corticosteroid and an immunosuppressive agent, hematuria and renal dysfunction developed about nine months later. The serum MPO-ANCA titer was elevated and the renal biopsy specimen revealed the presence of vasculitis. As the interstitial pneumonia improved after this treatment, the correct diagnosis may have been, not asbestosis, but MPO-ANCA-related interstitial pneumonia.
Inoue
Tetsuro
T
Department of Respiratory Medicine, Tenri Hospital 200 Mishimacho, Tenri, Nara 632-8552, Japan.
Tanaka
Eisaku
E
Kato
Terufumi
T
Sakuramoto
Minoru
M
Minakuchi
Masayoshi
M
Maeda
Yuji
Y
Maniwa
Ko
K
Terada
Kunihiko
K
Goto
Shunsuke
S
Takeda
Tomoshi
T
Yuba
Yoshiaki
Y
Kobashi
Yoichiro
Y
Noma
Satoshi
S
Taguchi
Yoshio
Y
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001195:Asbestosis / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000276:immunology*; D016273:Occupational Exposure; D009195:Peroxidase / Q000276:immunology; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase