Anticataleptic effect of energostim during single treatment with trifluoperazine.
Administration of trifluoperazine in a single dose of 3 mg/kg induced catalepsy and locomotor disorders in 86% intact animals, which persisted for 4 h. Catalepsy developed in only 15% animals pretreated with antihypoxic and antioxidant agent energostim in a dose of 230 mg/kg. The protective effect of energostim was associated with its ability to maintain the balance between dopaminergic, cholinergic, and adrenal activity in the substantia nigra and medulla oblongata during administration of neuroleptics.
Galenko-Yaroshevskii
P A
PA
Krasnodar Krai Research Medical Center, Tbilisi. pavelag@mail.ksma.kubannet.ru
Gurskaya
E V
EV
Chikobava
E A
EA
Sukoyan
G V
GV
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control*; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004837:Epinephrine / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D014268:Trifluoperazine / Q000633:toxicity
D000975:Antioxidants; D014150:Antipsychotic Agents; D014268:Trifluoperazine; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine