[Study on the levels of C-reactive protein and fibrinolytic activity in patients with obstructive sleep apnea syndrome].
OBJECTIVE
To study the changes of plasm CRP levels and the fibrinolytic activity in patients with obstructive sleep apnea syndrome (OSAS).


METHODS
Thirty-two patients with OSAS, who were free of other diseases and had never been treated for OSAS, were as test group, 30 adults without OSAS were as control group. Plasma high-sensitivity CRP (hsCRP) levels and tissue-type plasminogen activator (t-PA) activity, plasminogen activator inhibitor-1 (PAI-1) activity were measured in two groups.


RESULTS
In OSAS group the levels of CRP and the activity of PAI-1 were increased, the activity of t-PA were decreased as compared with control group (P < 0.01).


CONCLUSIONS
The OSAS patients are associated with elevated plasma CRP level and decreased fibrinolytic activity. The severity of OSAS is proportional to the CRP level.
Wang
Ying
Y
Department of Otolaryngology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yang
Haibo
H
Dong
Mingmin
M
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000097:blood
D017395:Plasminogen Activator Inhibitor 1; D002097:C-Reactive Protein; D010959:Tissue Plasminogen Activator