title: Primary central nervous system angiitis, amyloid angiopathy, and Alzheimer's pathology presenting with Balint's syndrome.
abstract: We report a patient who presented with Balint's syndrome as a manifestation of primary central nervous system angiitis. Clinical findings included simultanagnosia, optic ataxia, and optic apraxia. Pathologic evaluation demonstrated amyloid angiopathy and Alzheimer's plaques. The presence of primary central nervous system angiitis along with amyloid angiopathy and Alzheimer's plaques may not be coincidental. Angiitis may be a foreign body reaction to A4 amyloid deposition.
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, 3 East Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Dina A
authors.initials: DA
authors.lastname: Jacobs
authors.forename: Grant T
authors.initials: GT
authors.lastname: Liu
authors.forename: Peter T
authors.initials: PT
authors.lastname: Nelson
authors.forename: Steven L
authors.initials: SL
authors.lastname: Galetta
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D001072:Apraxias / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D001259:Ataxia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D016657:Cerebral Amyloid Angiopathy / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D013577:Syndrome; D020293:Vasculitis, Central Nervous System / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids