Effect of acute exposure to cadmium on the expression of calcitonin gene-related peptide (CGRP), calcitonin (CT), somatostatin (SST) and synaptophysin (SYN) in the C cells of the rat thyroid--a preliminary study.
The aim of the present study was to determine to what degree acute exposure to cadmium affects the expression of CGRP, CT, SST and SYN in the C cells of the rat thyroid. Animals from 7 experimental groups received CdCl2 iv. in doses of 3.5, 3, 2.5, 2, 1.5, 1 and 0.5 mg/kg b.w. respectively, while the control animals were given 0.9% NaCl iv. 24 hours after the iv. administration of CdCl2, a correlation was found between a single dose of cadmium and the intensity of the immunocytochemical reactions for CGRP, CT, SST and SYN in C cells of the rat thyroid when compared to the control. The weakest immunocytochemical reactions were noted in C cells of the thyroid of rats from Groups I and II, their intensity gradually increasing in Groups III, IV and V in comparison to the control. The reaction intensity in animals of Groups VI and VII resembled those of the control.
Czykier
Elzbieta
E
Department of Histology and Embryology, Medical University, Białystok, Poland. czykier@amb.edu.pl
Moniuszko-Jakoniuk
Janina
J
Sawicki
Bogusław
B
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D002105:Cadmium Poisoning; D002116:Calcitonin / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007150:Immunohistochemistry; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000378:metabolism*; D016708:Synaptophysin / Q000378:metabolism*; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D015415:Biomarkers; D016708:Synaptophysin; D002104:Cadmium; D013004:Somatostatin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide