Depressive state and paresthesia dramatically improved by intravenous MgSO4 in Gitelman's syndrome.
A 69-year-old woman was referred to our department for evaluation of hypokalemia, which had been treated by oral potassium for more than ten years. She complained of headache, knee joint pain, sleeplessness and paresthesia in extremities and, most prominently, depression. Laboratory data suggested Gitelman's syndrome, which is caused by mutations in the gene encoding the thiazide-sensitive Na-Cl cotransporter. Direct sequencing of the gene in this patient revealed homozygous mutation R964Q in exon 25. Intravenous supplement of MgSO4 dramatically improved both the depression and the paresthesia, suggesting that hypomagnesemia played a role in the clinical manifestations.
Enya
Mayumi
M
Third Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705.
Kanoh
Yoshinori
Y
Mune
Tomoatsu
T
Ishizawa
Masayoshi
M
Sarui
Hiroshi
H
Yamamoto
Mayumi
M
Takeda
Noriyuki
N
Yasuda
Keigo
K
Yasujima
Minoru
M
Tsutaya
Shoji
S
Takeda
Jun
J
D000368:Aged; D000471:Alkalosis / Q000175:diagnosis; D001477:Bartter Syndrome / Q000175:diagnosis*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis; D006996:Hypocalcemia / Q000175:diagnosis; D007008:Hypokalemia / Q000175:diagnosis; D007262:Infusions, Intravenous; D008275:Magnesium Deficiency / Q000175:diagnosis / Q000517:prevention & control*; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D010292:Paresthesia / Q000175:diagnosis / Q000188:drug therapy*; D018570:Risk Assessment; D013577:Syndrome; D016896:Treatment Outcome
D008278:Magnesium Sulfate