Membranous glomerulonephritis in chronic lymphocytic leukemia.
We present a case of chronic lymphocytic leukemia associated with nephrotic syndrome. Renal biopsy revealed membranous glomerulonephritis accompanied by interstitial monoclonal lymphocytic infiltration. Combination therapy with cyclophosphamide, vincristine, and prednisone (COP) was successful in inducing an effective response in chronic lymphocytic leukemia. Improvement of renal function and proteinuria was also observed.
Ziakas
Panayiotis D
PD
Department of Pathophysiology, Medical School, National University of Athens, M. Asias 75, Goudi, 11527 Athens, Greece.
Giannouli
Stavroula
S
Psimenou
Erasmia
E
Nakopoulou
Lydia
L
Voulgarelis
Michalis
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D001706:Biopsy; D003520:Cyclophosphamide / Q000627:therapeutic use; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D007668:Kidney / Q000473:pathology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D011507:Proteinuria; D014750:Vincristine / Q000627:therapeutic use
D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone