title: Dihydroethanoanthracene derivatives as in vitro malarial chloroquine resistance reversal agents.
abstract: The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24 chloroquine-resistant and 10 chloroquine-susceptible strains of Plasmodium falciparum from different countries. The 9,10-dihydroethanoanthracene derivatives clearly increase chloroquine susceptibility only in chloroquine-resistant isolates.
authors.affiliation: Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Boulevard Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Millet
authors.forename: Marylin
authors.initials: M
authors.lastname: Torrentino-Madamet
authors.forename: Sandrine
authors.initials: S
authors.lastname: Alibert
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.forename: Christiane
authors.initials: C
authors.lastname: Santelli-Rouvier
authors.forename: Joel
authors.initials: J
authors.lastname: Mosnier
authors.forename: Eric
authors.initials: E
authors.lastname: Baret
authors.forename: Jacques
authors.initials: J
authors.lastname: Barbe
authors.forename: Daniel
authors.initials: D
authors.lastname: Parzy
authors.forename: Bruno
authors.initials: B
authors.lastname: Pradines
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000873:Anthracenes; D000962:Antimalarials; D001952:Bridged-Ring Compounds; D002738:Chloroquine