Effect of the arginine-containing mu,delta-opiate receptor agonist sedatin on DNA synthesis in the epithelium of the gastric fundus in albino rats.
We studied the effect of arginine-containing mu,delta-opiate receptor agonist sedatin on DNA synthesis in the epithelium of the gastric fundus in albino rats. Fivefold intraperitoneal injection of sedatin in various doses increased the index of labeled nuclei. Similar changes were observed after intranasal and intraperitoneal treatment with sedatin in a dose of 10 microg/kg for 21 days. Administration of sedatin for 21 days prevented the decrease in weight gain induced by experimental stress. Our results suggest that arginine entering the composition of sedatin plays a role in its biological effects.
Fleishman
M Yu
MY
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk. f.marina@lycos.com
Kuznetsov
A V
AV
Deigin
V I
VI
Timoshin
S S
SS
D000281:Administration, Intranasal; D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017465:Receptors, Opioid, delta / Q000819:agonists*; D017450:Receptors, Opioid, mu / Q000819:agonists*
D009842:Oligopeptides; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; C493049:sedatin; D006632:Histamine; D004247:DNA