title: Adding a nicotine blocking agent to cigarette tapering.
abstract: A non-pharmacologic nicotine-blocking agent (Accu Drop; AD) was preliminarily tested in combination with cigarette tapering and brief counseling (C) in a random assignment, double-blind, placebo controlled, 6-week smoking cessation study (n = 60). It was hypothesized that the AD&C group would have higher rates of treatment completion and smoking abstinence than the placebo drop group plus counseling (PD&C). The participants were 37 women and 23 men averaging 24 cigarettes per day along with high Fagerstrom nicotine dependence scores (FTQ approximately 7) and high plasma cotinine levels (> 250ng/ml). There were no significant differences between groups for withdrawal scores, treatment completion (55%), or average number of sessions attended. Point prevalence followup evaluations were obtained 1 week, 1 month, and 6 months post projected treatment completion. Biochemically confirmed abstinence rates at followups did not differ between treatment groups (AD&C = 10%, 13%, 10% vs. PD&C = 3%, 10%, 13%). There is not enough evidence to suggest a Stage II trial.
authors.affiliation: Treatment Research Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. gariti_p@mail.trc.upenn.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Gariti
authors.forename: Arthur I
authors.initials: AI
authors.lastname: Alterman
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Lynch
authors.forename: Kyle
authors.initials: K
authors.lastname: Kampman
authors.forename: Thomas
authors.initials: T
authors.lastname: Whittingham
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D004311:Double-Blind Method; D005260:Female; D005503:Food Additives; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016540:Smoking Cessation / Q000379:methods*
chemical_list: D005503:Food Additives