title: Psychoactive medications and actigraphically scored sleep quality in frail nursing home patients.
abstract: OBJECTIVE
  The objective of this study was to examine the association between psychoactive medications and sleep quality in a sample of nursing home patients.
  
  
  METHODS
  We studied a baseline data collection for a clinical trial of a nonpharmacologic sleep intervention program.
  
  
  METHODS
  This study was conducted at six community nursing homes.
  
  
  METHODS
  We studied 168 nursing home patients.
  
  
  METHODS
  Sleep was recorded by wrist actigraphy for three to five nights under usual care conditions. Demographic and clinical data were collected by medical record reviews and patient assessments.
  
  
  RESULTS
  One or more routine psychoactive medications were being taken by 109 (65%) of the patients. Number of minutes of sleep, percent of time in bed asleep, and number of awakenings did not differ between those receiving and not receiving a psychoactive medication. Neither the use of antidepressants nor the use of only psychoactive medications reported to cause sedation was associated with significantly better sleep quality.
  
  
  CONCLUSIONS
  Psychoactive medications as a general class of drugs were not associated with better or worse sleep quality in this very frail nursing home population. The effect of individual classes of psychoactive drugs on sleep quality in this patient population requires further study.
authors.affiliation: Emory University School of Medicine, Atlanta, GA 30329, USA.
authors.forename: K Elizabeth
authors.initials: KE
authors.lastname: Greco
authors.forename: Christi
authors.initials: C
authors.lastname: Deaton
authors.forename: Michael
authors.initials: M
authors.lastname: Kutner
authors.forename: John F
authors.initials: JF
authors.lastname: Schnelle
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Ouslander
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000627:therapeutic use; D005260:Female; D016330:Frail Elderly / Q000706:statistics & numerical data*; D006707:Homes for the Aged / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D009735:Nursing Homes / Q000706:statistics & numerical data*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D012890:Sleep / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000188:drug therapy / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D011619:Psychotropic Drugs