title: Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitis.
abstract: We examined whether immunization with the nonpathogenic strain R-15 of herpes simplex virus-1 (HSV-1) may prevent the clinical and neuroendocrine changes induced by the pathogenic HSV-1 strain Syn17+. Inoculation of strain Syn17+ to control rats induced fever, marked motor hyperactivity and aggressive behavior, and increased serum ACTH, corticosterone (CS) and brain prostaglandin-E2 production. Mortality was 100%. Immunization with strain R-15 prior to challenge with Syn17+ induced the production of neutralizing antibodies to HSV-1 Syn17+, and abolished the above clinical and neuroendocrine changes. Mortality was completely prevented. These results indicate that immunization with HSV-1 strain R-15 protects rats from lethal HSV-1 encephalitis and prevents its clinical and neurochemical manifestations.
authors.affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah-Hebrew University Hospital, P.O. Box 12,000, Jerusalem 91120, Israel. tamir@hadassah.org.il
authors.forename: Tamir
authors.initials: T
authors.lastname: Ben-Hur
authors.forename: Anna
authors.initials: A
authors.lastname: Itzik
authors.forename: Ohr
authors.initials: O
authors.lastname: Barak
authors.forename: Yael
authors.initials: Y
authors.lastname: Asher
authors.forename: Yechiel
authors.initials: Y
authors.lastname: Becker
authors.forename: Raz
authors.initials: R
authors.lastname: Yirmiya
authors.forename: Joseph
authors.initials: J
authors.lastname: Weidenfeld
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D020803:Encephalitis, Herpes Simplex / Q000150:complications / Q000517:prevention & control*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology*; D011453:Prostaglandins / Q000032:analysis; D051381:Rats; D014611:Vaccination
chemical_list: D011453:Prostaglandins; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone