title: Alcohol consumption and risk of adult-onset acute myeloid leukemia: results from a Los Angeles County case-control study.
abstract: Few studies have examined the role of alcohol consumption in risk of adult acute myeloid leukemia (AML). Two previous case-control studies resulted in inconsistent findings. We report data from a Los Angeles County population-based case-control study in which 164 matched case-control pairs were asked about lifetime history of alcohol consumption and 136 cases were subtyped according to the French-American-British (FAB) criteria. Estimated categorical odds ratios (OR) adjusted for smoking and education were suggestive of a possible protective effect but trend tests were non-significant. Analyses by FAB subtype did not reveal subtype-specific associations but generally suffered from lack of power. Larger studies are needed to more thoroughly investigate the relationship between alcohol consumption and AML risk.
authors.affiliation: Department of Preventive Medicine, USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MS 44, Suites 4412-4413, Los Angeles 90033-800, USA. jpogoda@statology.com
authors.forename: Janice M
authors.initials: JM
authors.lastname: Pogoda
authors.forename: Peter W
authors.initials: PW
authors.lastname: Nichols
authors.forename: Susan
authors.initials: S
authors.lastname: Preston-Martin
mesh_terms: D000208:Acute Disease; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology*; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020011:Protective Agents / Q000494:pharmacology; D012307:Risk Factors
chemical_list: D020011:Protective Agents