title: Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study.
abstract: OBJECTIVE
  We investigated whether cervical shortening and high interleukin (IL)-8 in cervical mucus were valuable indications for treatment to prevent premature birth and preterm, pre-labor rupture of membranes (pPROM).
  
  
  METHODS
  Pregnant women were divided into group A, in which neither cervical IL-8 nor cervical length was measured in the middle trimester; and groups B and C, in which cervical length and cervical IL-8 were measured, and bed rest or cerclage was performed when cervical shortening was detected. In group B, vaginal washing with povidone iodine and insertion of chloramphenicol vaginal tablets were carried out in women with IL-8 elevations.
  
  
  RESULTS
  In group B, duration of pregnancy was significantly prolonged compared with group A and C, and occurrence of pPROM was significantly lower. No significant differences were found in those rates between groups A and C.
  
  
  CONCLUSIONS
  Successful treatment for women with IL-8 elevations in cervical mucus decreased rates of premature birth or pPROM.
authors.affiliation: Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Sakai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoneda
authors.forename: Tadashi
authors.initials: T
authors.lastname: Kasahara
authors.forename: Takashi
authors.initials: T
authors.lastname: Arai
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Okada
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Hosokawa
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Kato
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Soeda
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D002582:Cervix Mucus / Q000187:drug effects / Q000378:metabolism*; D002701:Chloramphenicol / Q000494:pharmacology / Q000627:therapeutic use; D004198:Disease Susceptibility; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000378:metabolism / Q000517:prevention & control*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D016209:Interleukin-8; D002701:Chloramphenicol