title: PASSCLAIM--body weight regulation, insulin sensitivity and diabetes risk.
abstract: BACKGROUND
  Insulin sensitivity is a key function in human metabolism because it has a crucial role in the development of disease that are increasingly common in modern society. Impaired insulin sensitivity is an important determinant of type 2 diabetes; moreover, it has been proposed as an independent risk factor for cardiovascular disease. Thus, reduced insulin sensitivity is strongly associated with the metabolic syndrome, which represents a cluster of metabolic abnormalities and cardiovascular risk factor. Insulin sensitivity can be modulated by different environmental factors, including dietary habits. Obesity, especially if associated with abdominal adiposity, impairs insulin-sensitivity while physical activity can improve it; however, the composition of the habitual diet is clearly an important regulator of this function.
  
  
  OBJECTIVE
  To evaluate methodologies and markers that can be used to substantiate existing and potential claims of beneficial effects of foods on relevant functions connected with body fat deposition, insulin sensitivity and blood glucose regulation.
  
  
  RESULTS
  We have reviewed the scientific basis for existing and potential claims, based not only on modifications of the target functions (body fat deposition, insulin sensitivity and blood glucose regulation) but also on modifications of other relevant associated functions (energy intake, energy expenditure, fat storage and oxidation, lipotoxicity, body fat composition, inflammation, oxidative stress, vascular function, glucose production and utilization). In this context we have identified a number of markers and evaluated appropriate method to measure and validate them.
  
  
  CONCLUSIONS
  Relevant functions contributing to overweight, the metabolic syndrome and diabetes have been identified. The evidence reviewed indicates that in this field the link between nutrition, biological responses and diseases is clearly established. Therefore, there is a strong potential to develop functional food science. The major gap in the evidence continues to be the lack of diet based intervention trials of sufficient duration to be relevant for affecting the natural history of these conditions.
authors.affiliation: Università degli Studi di Napoli, Federico II, Dip. di Medicina Clinica e Sperimentale, Via Sergio Pansini 5, 80131, Napoli, Italy.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Riccardi
authors.forename: Peter
authors.initials: P
authors.lastname: Aggett
authors.forename: Furio
authors.initials: F
authors.lastname: Brighenti
authors.forename: Nathalie
authors.initials: N
authors.lastname: Delzenne
authors.forename: Keith
authors.initials: K
authors.lastname: Frayn
authors.forename: Arie
authors.initials: A
authors.lastname: Nieuwenhuizen
authors.forename: Daphne
authors.initials: D
authors.lastname: Pannemans
authors.forename: Stephan
authors.initials: S
authors.lastname: Theis
authors.forename: Sandra
authors.initials: S
authors.lastname: Tuijtelaars
authors.forename: Bengt
authors.initials: B
authors.lastname: Vessby
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D001835:Body Weight; D003920:Diabetes Mellitus; D019937:Diagnostic Techniques and Procedures; D004032:Diet; D002149:Energy Intake; D004734:Energy Metabolism; D005502:Food; D058870:Food, Organic; D006293:Health Promotion; D006728:Hormones / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome; D018377:Neurotransmitter Agents / Q000502:physiology; D009765:Obesity; D012307:Risk Factors; D014131:Trace Elements
chemical_list: D001786:Blood Glucose; D006728:Hormones; D018377:Neurotransmitter Agents; D014131:Trace Elements