title: Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.
abstract: Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.
authors.affiliation: Department of Pharmacology, Göteborg University, P.O.B. 431, SE 405 30 Göteborg, Sweden.
authors.forename: Hoi-Por
authors.initials: HP
authors.lastname: Ho
authors.forename: Lars
authors.initials: L
authors.lastname: Westberg
authors.forename: Kristina
authors.initials: K
authors.lastname: Annerbrink
authors.forename: Marie
authors.initials: M
authors.lastname: Olsson
authors.forename: Jonas
authors.initials: J
authors.lastname: Melke
authors.forename: Staffan
authors.initials: S
authors.lastname: Nilsson
authors.forename: Fariba
authors.initials: F
authors.lastname: Baghaei
authors.forename: Roland
authors.initials: R
authors.lastname: Rosmond
authors.forename: Göran
authors.initials: G
authors.lastname: Holm
authors.forename: Per
authors.initials: P
authors.lastname: Björntorp
authors.forename: Sven
authors.initials: S
authors.lastname: Andersch
authors.forename: Christer
authors.initials: C
authors.lastname: Allgulander
authors.forename: Elias
authors.initials: E
authors.lastname: Eriksson
mesh_terms: D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011980:Receptors, Progesterone / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D011980:Receptors, Progesterone