The pathogenesis of multiple sclerosis: is it really a primary inflammatory process?
The pathogenesis of multiple sclerosis (MS) remains unknown. Although inflammation, demyelination and axonal injury are all involved, the primary pathogenic process is not clear. In this paper we challenge the hypothesis that MS is a primary inflammatory condition, and suggest that axonal damage may occur independently.
Maggs
F G
FG
University Department of Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK. fgmaggs@doctors.org.uk
Palace
J
J
D001369:Axons / Q000276:immunology*; D006801:Humans; D009103:Multiple Sclerosis / Q000209:etiology* / Q000276:immunology* / Q000503:physiopathology; D009443:Neuritis / Q000276:immunology* / Q000503:physiopathology