Effects of high-dose RU-486 treatment on climacteric complaints in hysterectomized postmenopausal women: a 6-week pilot study.
We investigated the effect of the anti-progestogen mifepristone (RU-486) on climacteric complaints. Four hysterectomized postmenopausal women, with at least 35 hot flushes per week, were treated with daily 200mg RU-486 for 6 weeks. RU-486 did not significantly improve climacteric complaints. Although this result does not support further clinical research with this dose of RU-486 for the treatment of climacteric complaints, potential effects of higher, but more interestingly of lower, dosages of RU-486 cannot be excluded.
Verhoeven
Marieke O
MO
van der Mooren
Marius J
MJ
Coelingh Bennink
Herjan J T
HJ
van der Linden
René F
RF
D002979:Climacteric / Q000187:drug effects*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015735:Mifepristone / Q000008:administration & dosage*; D010865:Pilot Projects; D017698:Postmenopause
D015735:Mifepristone