Synthesis of a polysulfated heparin degradation product.
Two suitable methods for the synthesis of the heparin degradation product 2,5-anyhydro-3-O-(alpha-L-idopyranosyluronate)-D-mannitol hexa O-sulfate are reported. The synthesis pathways start from D-glucose and D-glucosamine.
Kuszmann
J
J
IVAX Drug Research Institute, Budapest, Hungary.
Medgyes
G
G
Boros
S
S
D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000138:chemical synthesis*; D005944:Glucosamine / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D006493:Heparin / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D013431:Sulfates / Q000138:chemical synthesis
C487699:2,5-anyhydro-3-O-(alpha-L-idopyranosyluronate)-D-mannitol hexa-O-sulfate; D004187:Disaccharides; D007202:Indicators and Reagents; D013431:Sulfates; D006493:Heparin; D005947:Glucose; D005944:Glucosamine