Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration.
Experimental studies suggest that cytokine production may be triggered by seizure activity. Here we determined the levels of interleukin-6 (IL-6) and its soluble receptor components (sIL-6R and sGp130) in CSF and serum from control subjects and patients after different types of seizures. IL-6 levels were increased after seizures, whereas sIL-6R levels were decreased. Interestingly, the levels of IL-6 were strongly increased after recurrent generalized tonic-clonic seizures (GTCS), whereas after single tonic-clonic or prolonged partial seizures IL-6 levels were increased to lesser extent. These results provide further support for a hypothesis of cytokine production induced by seizure activity per se.
Lehtimäki
K A
KA
Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, 33521 Tampere, Finland. kai.lehtimaki@uta.fi
Keränen
T
T
Huhtala
H
H
Hurme
M
M
Ollikainen
J
J
Honkaniemi
J
J
Palmio
J
J
Peltola
J
J
D015703:Antigens, CD / Q000097:blood / Q000134:cerebrospinal fluid; D050822:Cytokine Receptor gp130; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008562:Membrane Glycoproteins / Q000097:blood / Q000134:cerebrospinal fluid; D019947:Receptors, Interleukin-6 / Q000032:analysis; D012640:Seizures / Q000276:immunology* / Q000503:physiopathology*
D015703:Antigens, CD; C494199:IL6ST protein, human; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130