Increased prevalence of cholelithiasis in Gaucher disease: association with splenectomy but not with gilbert syndrome.
OBJECTIVE
The purpose of this study is to ascertain the incidence of gallstones among adult patients with type 1 Gaucher disease and whether the presence of the UDPGT1 polymorphism (Gilbert syndrome), increases the incidence of gallstones.


BACKGROUND
Cholelithiasis was been observed among patients with type I Gaucher disease with variable frequency. Too, studies have addressed the possibility of an association between Gilbert syndrome and formation of bilirubinate gallstones in hereditary spherocytosis wherein, like Gaucher disease, there is hemolysis of blood cell membranes.


METHODS
Medical records of all adult patients with type 1 disease in a referral clinic were reviewed for evidence of gallstones or cholecystectomy. Blood samples were collected for molecular analysis for Gilbert syndrome.


RESULTS
Of 323 adult patients, 82 patients (25.4%), 54 women (65.9%) and 28 men (34.1%), had evidence of gallbladder disease (P < 0.001 relative to normal white controls). There was a statistically significant increase (P < 0.001) for all groups above the ages of 20 years other than for men aged 40 to 49 years. There was a statistically significant association between splenectomy and both cholelithiasis (P = 0.022) and Gilbert syndrome (P = 0.002).


CONCLUSIONS
This study highlights an increase incidence of cholelithiasis but not Gilbert syndrome among patients with Gaucher disease. Storage of glycolipid per se or an immune reaction to storage, may explain these findings.
Ben Harosh-Katz
Miriam
M
Gaucher Clinic and the Department of Diagnostic Radiology, Shaare Zedek Medical Center, Jerusalem, Israel.
Patlas
Michael
M
Hadas-Halpern
Irith
I
Zimran
Ari
A
Elstein
Deborah
D
D000328:Adult; D002769:Cholelithiasis / Q000097:blood / Q000209:etiology / Q000235:genetics*; D005260:Female; D005776:Gaucher Disease / Q000097:blood / Q000150:complications* / Q000235:genetics*; D005878:Gilbert Disease / Q000097:blood / Q000150:complications / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D013156:Splenectomy