title: Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.
abstract: Ocimum sanctum (OS) is known to possess various therapeutic properties. We evaluated its anti-ulcerogenic activity in cold restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models in Sprague-Dawley rats, histamine-induced duodenal (HST) ulcer in guinea pigs, and ulcer-healing activity, in acetic acid-induced (AC) chronic ulcer model. We found that OS, decreased the incidence of ulcers and also enhanced the healing of ulcers. OS at a dose of 100 mg/kg was found to be effective in CRU (65.07%), ASP (63.49%), AL (53.87%), PL (62.06%), and HST (61.76%) induced ulcer models and significantly reduced free, total acidity and peptic activity by 72.58, 58.63, 57.6%, respectively, and increased mucin secretion by 34.61%. Additionally, OS completely healed the ulcers within 20 days of treatment in AC. We observed that anti-ulcer effect of OS may be due to its cytoprotective effect rather than antisecretory activity. Conclusively, OS was found to possess potent anti-ulcerogenic as well as ulcer-healing properties and could act as a potent therapeutic agent against peptic ulcer disease.
authors.affiliation: Division of Pharmacology, Central Drug Research Institute, P.O. Box 173, Lucknow 226001, UP, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Dharmani
authors.forename: Vijay Kumar
authors.initials: VK
authors.lastname: Kuchibhotla
authors.forename: Rakesh
authors.initials: R
authors.lastname: Maurya
authors.forename: Sudhir
authors.initials: S
authors.lastname: Srivastava
authors.forename: Sharad
authors.initials: S
authors.lastname: Sharma
authors.forename: Gautam
authors.initials: G
authors.lastname: Palit
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D000431:Ethanol; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D008297:Male; D031339:Ocimum; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D006632:Histamine; D001241:Aspirin