HPLC profiling of Trp-related metabolites in humans.
Screening for metabolic abnormalities of Trp has been introduced using SPE pre-treatment, TLC and/or two HPLC procedures. The excretory pattern in urine (occasionally also plasma and CSF levels) has been followed in a group of 390 children showing various symptoms of a metabolic defect and in 195 patients with skin diseases, namely those associated with photosensitivity, such as porphyria, vitiligo, alopecia, psoriasis, erythematodes, and others. Excretory abnormalities of either indican, kynurenine, 3-hydroxyanthranilic acid or indolylacryloylglycine have been occasionally combined with myopathy, seizures, liver and intestinal symptoms. Several indoles and kynurenine derivatives present changes in the alopecia group and the vitiliginous patients.
Marklová
Eliska
E
Charles University, Faculty of Medicine, Department of Paediatrics, Hradec Králové, Czech Republic. marklova@lfhk.cuni.cz
Albahri
Ziad
Z
Nozicková
Marie
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D007223:Infant; D008661:Metabolism, Inborn Errors / Q000378:metabolism; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000378:metabolism; D012871:Skin Diseases / Q000378:metabolism; D014364:Tryptophan / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism*
D014364:Tryptophan