title: [Chromosome aberration analysis of peripheral lymphocytes in workers exposed to benzene].
abstract: OBJECTIVE
  To study the effects of benzene exposure on chromosome aberration of peripheral lymphocytes in workers.
  
  
  METHODS
  Measure the benzene concentration with 3M passive dosimetry badges and analyze chromosome aberrations of peripheral lymphocytes using non-banding method.
  
  
  RESULTS
  The numerically aberrated cell rate of the workers exposed by benzene [13.00% (2.50%-21.00%)] was significantly higher than that of the controls [10.50% (3.50%-18.00%)] (P < 0.05), and the aberrated cell rate (excluded gaps) [14.50% (5.00%-23.50%)] was significantly higher than that of the controls [11.75(3.50-18.00)] (P < 0.05), too; the P values of the dose-effect relationships between hyperploidy cell rate, numerically aberrated cell rate and aberrated cell rate (excluded gaps) and 8 h-TWA were 0.0008, 0.3741 and 0.2816, respectively, and the P values of the dose-effect relationships between those and the cumulative exposure were 0.0009, 0.0376 and 0.0486, respectively; the premature centromere division cell rate of the benzene-exposed workers [1.75% (0-19.50%)] was not significantly higher than that of the controls [1.00% (0-15.00%)] (P > 0.05).
  
  
  CONCLUSIONS
  Benzene exposure resulted in an increase of chromosome aberrations of the peripheral lymphocytes, which was in a dose-effect relationship manner; whether benzene exposure could induce premature centromere division deserves further studies.
authors.affiliation: Institute for Occupational Health and Poison Control, China CDC, Beijing 100050, China.
authors.forename: Zhiying
authors.initials: Z
authors.lastname: Ji
authors.forename: Guilan
authors.initials: G
authors.lastname: Li
authors.forename: Linglin
authors.initials: L
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Gao
mesh_terms: D000328:Adult; D001554:Benzene / Q000009:adverse effects*; D002503:Centromere / Q000187:drug effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012775:Shoes
chemical_list: D001554:Benzene