[The role of synthetic hydroxyapatite solution in the destructive process of arteriosclerosis].
Presented work is a pilot research on dissolving of homogeneous synthetic hydroxyapatite, being chemically analogous to the hydroxyapatite formed in human organism. Crystallization of hydroxyapatite (HA) in human arteries also known as calcification is a complex process leading to dysfunctions in the functioning of human blood system and--in effect--to dysfunction in functioning of tissues and organs [1]. Mineralization of blood vessels is a complicated process and can appear in two forms: visible and hidden, which can be organic or inorganic [2]. With inorganic mineralization there are concerned primarily phosphoranes of Calcium, mostly apathites, while the organic mineralization is represented by organic substances like cholesterol, fats, lipids [2, 3]. The forming of crystals, fats, lipids etc. in arteries is an effect of continuation of the processes started by hidden mineralization [1]. Research was focused on the possibilities of dissolving the visible, inorganic mineralization, represented by synthetic hydroxyapatite. In the work, there are presented preliminary results of biochemical studies on dissolving of the synthetic hydroxyapatite. The processes of dissolving of this compound took place in dynamic conditions. The organic solutions of hawthorn, onion and garlic of various concentrations--2.5%, 5%, 7.5%--were used as the solvents. These herbs show anti-calcification effects. The preliminary results of the experiments confirm the hypothesis that the solutions of these herbs free the Ca and P ions from the grains of synthetic HA (in varying flowing pH and speed conditions). This research encourages further analysis of the processes of dissolving hydroxyapatite--either synthetic or coming from human body.
Lipnicka
Patrycja
P
Zakład Mineralogii, Petrografii i Geochemii Akademii Górniczo-Hutniczej al. Mickiewicza 30, 30-059 Kraków.
Pawlikowski
Maciej
M
Pfttzner
Roman
R
D000975:Antioxidants / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D027825:Crataegus; D004305:Dose-Response Relationship, Drug; D017886:Durapatite / Q000737:chemistry*; D005737:Garlic; D006801:Humans; D066298:In Vitro Techniques; D019697:Onions; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D012996:Solutions
D000975:Antioxidants; D010936:Plant Extracts; D012996:Solutions; D017886:Durapatite