title: Glucagon-like peptide 1 (GLP-1) and eating.
abstract: New information regarding gastrointestinal mechanisms that participate in the control of food intake has extended our understanding of appetite control. Although each new signaling pathway discovered in the gut is a potential target for drug development in the treatment of obesity, the growing number of such signaling molecules indicates that a highly complex process controls food intake. The present summary focuses on the role of glucagon-like peptide 1 (GLP-1) in this regulatory process. The different biological effects of GLP-1 (glucose-lowering properties, inhibition of appetite and food intake) provide a powerful impetus for development of GLP-1-based new drugs.
authors.affiliation: Division of Gastroenterology, University Hospital, Basel, Switzerland.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Gutzwiller
authors.forename: Lukas
authors.initials: L
authors.lastname: Degen
authors.forename: Ludwig
authors.initials: L
authors.lastname: Heuss
authors.forename: Christoph
authors.initials: C
authors.lastname: Beglinger
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D004064:Digestive System; D004435:Eating / Q000502:physiology*; D005934:Glucagon / Q000819:agonists / Q000276:immunology / Q000502:physiology*; D052216:Glucagon-Like Peptide 1; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D010446:Peptide Fragments / Q000819:agonists / Q000276:immunology / Q000502:physiology*; D011498:Protein Precursors / Q000819:agonists / Q000276:immunology / Q000502:physiology*; D018027:Receptors, Glucagon / Q000502:physiology
chemical_list: D000906:Antibodies; C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D010446:Peptide Fragments; D011498:Protein Precursors; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1; D005934:Glucagon