title: Antioxidant and nitric oxide synthase activation properties of Auricularia auricula.
abstract: In vitro evaluation of antioxidant activities of Auricularia auricula showed significant inhibition of lipid peroxidation, and potent hydroxyl radical scavenging activity when compared with standard drug catechin. IC5o value of crude, boiled and ethanolic extracts of A. auricula represented 403, 510, and 373 microg/ml respectively in case of hydroxyl radical scavenging activity and 310, 572 and 398 microg/ml respectively in case of lipid peroxidation. Furthermore, crude, boiled and ethanolic extracts also increase significantly nitric oxide production (664, 191 and 850 pmole/mg dry wt/hr respectively) over the control. The present results revealed that A. auricula had potential therapeutic use.
authors.affiliation: Biotechnology Research Laboratory, Post Graduate Department of Botany, Darjeeling Government College, Darjeeling 734 101, India. krishnendua@rediffmail.com
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Acharya
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Samui
authors.forename: Manjula
authors.initials: M
authors.lastname: Rai
authors.forename: Bani Brata
authors.initials: BB
authors.lastname: Dutta
authors.forename: Rupa
authors.initials: R
authors.lastname: Acharya
mesh_terms: D000363:Agaricales / Q000201:enzymology*; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D004789:Enzyme Activation; D004912:Erythrocytes / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D017665:Hydroxyl Radical; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D013053:Spectrophotometry; D013481:Superoxides / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D013481:Superoxides; D017665:Hydroxyl Radical; D000431:Ethanol; D019001:Nitric Oxide Synthase