Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG/Rij rats.
Corticosteroids mediate seizure activity in different epilepsy models or epilepsies. However, for childhood absence epilepsy, a nonconvulsive type of epilepsy, direct evidence for corticosteroid seizure modulation is lacking. Thus, in the present study, we analysed the acute systemic effects of different doses of the corticosteroid corticosterone on seizure activity in a well-validated animal model of childhood absence epilepsy, the WAG/Rij rat. We found a time- and dose-dependent increase in the number of spike-wave discharges (SWD) in the EEG, with 500 microg/kg of corticosterone causing a 327% increase in discharges compared to baseline 15-30 min after administration. No treatment effects were found on mean duration of SWD and behavior. Our data indicate that corticosterone in a physiologically relevant dose can aggravate absence seizures in a rapid but transient way. Regarding the time course of the effect, we suggest that corticosterone is acting nongenomically, possibly via a temporary increase of excitatory amino acids.
Schridde
Ulrich
U
NICI, Department of Biological Psychology, University of Nijmegen, P.O. Box 9104, 6500 HE, Nijmegen, The Netherlands. u.schridde@nici.kun.nl
van Luijtelaar
Gilles
G
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004832:Epilepsy, Absence / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D051381:Rats; D013997:Time Factors
D003345:Corticosterone