title: Therapeutics targeting the innate immune system.
authors.affiliation: Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA. ulevitch@scripps.edu
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ulevitch
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000943:Antigens, Differentiation / Q000502:physiology; D001249:Asthma / Q000276:immunology / Q000628:therapy; D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000502:physiology; D007113:Immunity, Innate / Q000187:drug effects; D007167:Immunotherapy; D007239:Infections / Q000276:immunology / Q000628:therapy; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008562:Membrane Glycoproteins / Q000145:classification / Q000235:genetics / Q000502:physiology; D051379:Mice; D018448:Models, Immunological; D005810:Multigene Family; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B / Q000502:physiology; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D009838:Oligodeoxyribonucleotides / Q000627:therapeutic use*; D011956:Receptors, Cell Surface / Q000145:classification / Q000235:genetics / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology; D015398:Signal Transduction; D051193:Toll-Like Receptors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000943:Antigens, Differentiation; C408982:CPG-oligonucleotide; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; C507779:MYD88 protein, human; D008562:Membrane Glycoproteins; C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88; D016328:NF-kappa B; C119067:NOD1 protein, human; C429018:NOD2 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D009838:Oligodeoxyribonucleotides; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D051193:Toll-Like Receptors