title: Giant chalazia in the hyperimmunoglobulinemia E (hyper-IgE) syndrome.
abstract: OBJECTIVE
  To report the occurrence of recurrent multiple giant chalazia in the hyperimmunoglobulin E syndrome (hyper-IgE syndrome or Job syndrome).
  
  
  METHODS
  Two patients with hyperimmunoglobulinemia E (>500 IU/ml) had ophthalmologic examination and surgical treatment for chalazia of the eyelids.
  
  
  RESULTS
  The hyper-IgE syndrome is a rare immunodeficiency and multisystem disorder characterized by recurrent skin and pulmonary abscesses, connective tissue abnormalities, and elevated levels of serum IgE. In two patients with the hyper-IgE syndrome, multiple giant chalazia were seen in upper and lower eyelids. Despite surgical incision new giant chalazia arose.
  
  
  CONCLUSIONS
  Recurrent multiple giant chalazia may occur as an ophthalmic feature of the hyper-IgE syndrome.
authors.affiliation: Institute of Ophthalmology, University Medical Centre Nijmegen, Nijmegen, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Crama
authors.forename: A M P
authors.initials: AM
authors.lastname: Toolens
authors.forename: J W M
authors.initials: JW
authors.lastname: van der Meer
authors.forename: J R M
authors.initials: JR
authors.lastname: Cruysberg
mesh_terms: D000293:Adolescent; D000328:Adult; D017043:Chalazion / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D005143:Eyelids / Q000473:pathology; D005260:Female; D006801:Humans; D007589:Job Syndrome / Q000150:complications* / Q000175:diagnosis; D008297:Male; D012008:Recurrence