title: Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.
abstract: Of the several kinds of therapy-related leukemia, therapy-related acute promyelocytic leukemia (t-APL) is most closely associated with topoisomerase II inhibitor administration for treatment of malignancies in adults. Although rare in children, the majority of therapy-related malignancies have been etoposide-related APL associated with Langerhans cell histiocytosis. The authors describe the development of t-APL after chemotherapy administered for non-Hodgkin's lymphoma (NHL) in an 8-year-old girl. One month after cessation of the 3-year chemotherapy regimen of doxorubicin and other agents but not etoposide or radiotherapy, the patient was diagnosed with t-APL with positive PML-RARA molecular abnormality. The patient attained a complete remission following treatment with all-trans retinoic acid-containing chemotherapy. Thereafter, she successfully received hematopoietic stem cell transplantation from an HLA-matched sibling donor. Development of t-APL associated with NHL in children appears to be rare.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan. ayaoga@koto.kpu-m.ac.jp
authors.forename: Aya
authors.initials: A
authors.lastname: Ogami
authors.forename: Akira
authors.initials: A
authors.lastname: Morimoto
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Hibi
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Todo
authors.forename: Tohru
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Kanako
authors.initials: K
authors.lastname: Mori
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Imamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishida
authors.forename: Takao
authors.initials: T
authors.lastname: Yoshihara
authors.forename: Akihiro
authors.initials: A
authors.lastname: Iguchi
authors.forename: Masue
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Imashuku
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D016133:Polymerase Chain Reaction; D012074:Remission Induction; D014178:Translocation, Genetic
chemical_list: D000970:Antineoplastic Agents