title: Zinc-proline catalyzed pathway for the formation of sugars.
abstract: Zn-proline catalyzes the aldolisation of unprotected glycolaldehyde in water to give tetroses and hexoses; threose (33% of the product mixture) was formed with 10% enantiomeric excess of the D-isomer.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012, Bern, Switzerland.
authors.forename: Jacob
authors.initials: J
authors.lastname: Kofoed
authors.forename: Miguel
authors.initials: M
authors.lastname: Machuqueiro
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Reymond
authors.forename: Tamis
authors.initials: T
authors.lastname: Darbre
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry*; D002241:Carbohydrates / Q000138:chemical synthesis*; D002384:Catalysis; D006601:Hexoses / Q000138:chemical synthesis; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D012996:Solutions; D013237:Stereoisomerism; D013780:Tetroses / Q000138:chemical synthesis; D015032:Zinc / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D006601:Hexoses; D012996:Solutions; D013780:Tetroses; D011392:Proline; D000079:Acetaldehyde; D015032:Zinc; C010972:glycolaldehyde