title: Comparison of the healing process in plated and non-plated fractures of the mandible in rats.
abstract: We compared the healing process of plated and non-plated fractures. The mandibles of 72 male Wistar rats were fractured and more either plated or not plated (n = 36 in each group). The healing process of the two conditions was studied histologically and immunohistochemically using a specific antibody to bone morphogenetic protein-2 (BMP-2). The results showed that the healing process in the plated group was delayed by one week compared with the non-plated group. Trauma to the surrounding soft tissues affected the healing process. BMP-2 was expressed at all stages in both groups. We conclude that the healing process is disturbed by the fixing of a plate; that periosteum is one of the main sources of osteogenic cells; and that BMP-2 is an important regulator of morphogenesis.
authors.affiliation: Department of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan. rasubala@bioreg.kyushu-u.ac.jp
authors.forename: L
authors.initials: L
authors.lastname: Rasubala
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: A A S
authors.initials: AA
authors.lastname: Islam
authors.forename: K
authors.initials: K
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Iijima
authors.forename: M
authors.initials: M
authors.lastname: Ohishi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000032:analysis / Q000502:physiology*; D001860:Bone Plates / Q000009:adverse effects; D005593:Fracture Fixation, Internal / Q000009:adverse effects / Q000379:methods; D017102:Fracture Healing / Q000502:physiology*; D008297:Male; D008337:Mandibular Fractures / Q000503:physiopathology* / Q000601:surgery; D010006:Osteoblasts / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D016212:Transforming Growth Factor beta
chemical_list: D015415:Biomarkers; C525720:Bmp2 protein, rat; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta