S100 in mild traumatic brain injury.
OBJECTIVE
To examine the diagnostic value of S100 in mild traumatic brain injury (MTBI).


METHODS
Prospective cohort study.


METHODS
S100B, S100A1B and S100BB concentrations were examined in sera from patients with MTBI with an arrival Glasgow Coma Scale score of 15 or 14, patients with orthopaedic injuries and non-injured subjects.


RESULTS
Mean values and proportions of subjects above cut-off limits for S100B and S100A1B were significantly higher in each trauma group than in non-injured controls, but only for S100A1B when patients with MTBI were compared with controls with orthopaedic injuries. Using a 97.5 percentile cut-off limit, the sensitivity of S100A1B for MTBI vs orthopaedic injury was 61% (95% confidence interval (CI) 49-73%), specificity 77% (95% CI 62-93%). The area under the ROC curve did not approach 0.9 for any cut off limit.


CONCLUSIONS
Diagnostic validity of S100 in acute MTBI was not demonstrated. S100A1B has merits for long-term prognostic studies.
Nygren De Boussard
Catharina
C
Department of Rehabilitation Medicine, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. catharina.nygren@reh.ds.sll.se
Fredman
Pam
P
Lundin
Anders
A
Andersson
Kerstin
K
Edman
Gunnar
G
Borg
Jörgen
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000293:injuries; D001930:Brain Injuries / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D009418:S100 Proteins / Q000097:blood*; D012720:Severity of Illness Index; D013997:Time Factors
D015415:Biomarkers; D009418:S100 Proteins