Liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometry (LC-FTICR MS): an early overview.
Fourier-transform ion cyclotron resonance mass spectrometry has developed into one of the most powerful analytical techniques. This unique technique enables acquisition of high-resolution mass spectra with high accuracy, which in turn enables determination of the elemental composition of the analyzed compounds. Coupling with liquid chromatography affords a separation technique with a high-resolution "detector" which can be used to investigate very complex matrices. In this review some important instrumental developments are described and applications are presented; these show the advantages and disadvantages of this combination.
Schrader
Wolfgang
W
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany. wschrader@mpi-muelheim.mpg.de
Klein
Heinz-Werner
HW
D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D017357:Cyclotrons; D005583:Fourier Analysis; D013058:Mass Spectrometry / Q000295:instrumentation* / Q000379:methods*; D012680:Sensitivity and Specificity