Recurrent atrial ectopic tachycardia following chemotherapy with ifosfamide.
In most pediatric tumors, particularly sarcomas, cyclophosphamide or ifosfamide represent essential first-line chemotherapeutic agents. Whereas cyclophosphamide is known to be associated with a well-defined cardiomyopathy, only a few cardiac complications following ifosfamide chemotherapy have been observed to date. Here we report a patient treated for Ewing sarcoma with multiple pulmonary and osseous metastases who repeatedly developed a supraventricular tachyarrhythmia following administration of ifosfamide as part of a polychemotherapy regimen.
Müller
Lars
L
Department of Pediatric Hematology, Oncology and Immunology, University Medical Center, Heinrich-Heine-University, Düsseldorf, Germany.
Kramm
Christof M
CM
Lawrenz
Wolfgang
W
Schmidt
Klaus G
KG
Wessalowski
Rüdiger
R
D000970:Antineoplastic Agents / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D004562:Electrocardiography; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects*; D008297:Male; D012008:Recurrence; D012512:Sarcoma, Ewing / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D013612:Tachycardia, Ectopic Atrial / Q000139:chemically induced*
D000970:Antineoplastic Agents; D007069:Ifosfamide