Differential modulation of nociceptive neural responses in medial and lateral pain pathways by peripheral electrical stimulation: a multichannel recording study.
It is well accepted that peripheral electrical stimulation (PES) can produce an analgesic effect in patients with acute and chronic pain. However, the neural basis underlying stimulation-induced analgesia remains unclear. In the present study, we examined the pain-related neural activity modified by peripheral stimulation in rats. The stimulation frequency of pulses applied to needle electrodes in the hindlimb was 2 Hz alternating with 100 Hz, with 0.6 ms pulse width for 2 Hz and 0.2 ms for 100 Hz. The intensity of the stimulation was increased stepwise from 1 to 3 mA with each 1-mA step lasting for 10 min. The nociceptive neural and behavioral responses were examined immediately after the termination of stimulation. Using a multiple-channel recording technique, we simultaneously recorded the activity of many single neurons located in the primary somatosensory and anterior cingulate cortex (ACC), as well as the ventral posterior and medial dorsal thalamus in behaving rats. Our results showed that peripheral electrical stimulation significantly reduced the nociceptive responses in ventroposterior thalamus and somatosensory cortex, indicating an inhibition of nociceptive processing. In contrast, the analgesic stimulation produced a significant increase in mediodorsal thalamus while a less significant decrease in cingulate cortex, reflecting a complicated effect associated with combined antinociceptive activation and nociceptive suppression. These results support the idea that peripheral electrical stimulation can ultimately alter the pain perception by specifically inhibiting the nociceptive transmission in the sensory pathway while mobilizing the antinociceptive action in the affective pathway, thus to produce pain relief.
Wang
Jin-Yan
JY
Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, PR China.
Zhang
Han-Ti
HT
Han
Ji-Sheng
JS
Chang
Jing-Yu
JY
Woodward
Donald J
DJ
Luo
Fei
F
D000818:Animals; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006179:Gyrus Cinguli / Q000503:physiopathology; D006358:Hot Temperature; D020645:Mediodorsal Thalamic Nucleus / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology* / Q000534:rehabilitation*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013003:Somatosensory Cortex / Q000503:physiopathology; D020651:Ventral Thalamic Nuclei / Q000503:physiopathology*