[Postvaricella purpura fulminans].
Purpura fulminans (PF) is an infrequent complication of varicella characterized by the progressive development of purpuric or painful ecchymotic lesions associated with biochemical alternations typical of consumption coagulopathy. Activation of coagulation is due to a marked and prolonged decrease in protein S, which is probably secondary to the formation of antiprotein S antibodies. The mechanism responsible for the synthesis of these autoantibodies is unknown. We present three cases of postvaricella PF and review the clinical and biochemical characteristics of this entity, as well as current diagnostic and therapeutic recommendations.
Alsina Manrique de Lara
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L
Sección de Urgencias, Servicio de Pediatría, Hospital Sant Joan de Déu-Clínic, Universitat de Barcelona, Paseo Sant Joan de Déu, 08950 Esplugues de Llobregat, Barcelona, Spain. cluaces@hsjdbcn.org
Zambudio Sert
S
S
Pizà Oliveras
A
A
Toll Costa
T
T
García García
J J
JJ
Luaces Cubells
C
C
D000906:Antibodies; D001323:Autoantibodies; D002644:Chickenpox / Q000150:complications* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D017293:Protein S / Q000276:immunology
D000906:Antibodies; D001323:Autoantibodies; D017293:Protein S