Open-label dose-escalation study of oral 1-octanol in patients with essential tremor.
Twenty-one single oral doses of 1-octanol were given to patients with essential tremor (ET) in an open-label dose-escalation study. The drug was well tolerated up to 64 mg/kg. The main side effect was an unusual taste. No overt intoxication was seen. There was evidence for efficacy, with a significant reduction in tremor amplitude as measured by accelerometry and handwriting that was maximal at 2 hours. Higher doses may produce more sustained benefit.
Shill
H A
HA
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1428, USA.
Bushara
K O
KO
Mari
Z
Z
Reich
M
M
Hallett
M
M
D020003:1-Octanol / Q000008:administration & dosage* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015507:Drugs, Investigational / Q000008:administration & dosage* / Q000627:therapeutic use; D020329:Essential Tremor / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged
D015507:Drugs, Investigational; D020003:1-Octanol