Antimicrobial susceptibility patterns and macrolide resistance genes of beta-hemolytic streptococci in Korea.
In 540 beta-hemolytic streptococci, the rates of resistance to tetracycline, chloramphenicol, erythromycin, and clindamycin were 80.0, 22.8, 20.2, and 19.1%, respectively. Of the erythromycin-resistant isolates, 63.3% had the constitutive macrolide-lincosamide-streptogramin B (MLS(B)) resistance phenotype, 23.9% had the M phenotype, and 12.8% had the inducible MLS(B) resistance phenotype. The constitutive MLS(B) resistance phenotype with the erm(B) gene was dominant in Korea.
Uh
Young
Y
Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Ilsan-dong 162, Wonju, Kangwon-do, South Korea. u931018@wonju.yonsei.ac.kr
Jang
In Ho
IH
Hwang
Gyu Yel
GY
Lee
Mi Kyung
MK
Yoon
Kap Jun
KJ
Kim
Hyo Youl
HY
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D005798:Genes, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D018942:Macrolides; D004917:Erythromycin