title: Mutations affecting retina development in Medaka.
abstract: In a large scale mutagenesis screen of Medaka we identified 60 recessive zygotic mutations that affect retina development. Based on the onset and type of phenotypic abnormalities, the mutants were grouped into five categories: the first includes 11 mutants that are affected in neural plate and optic vesicle formation. The second group comprises 15 mutants that are impaired in optic vesicle growth. The third group includes 18 mutants that are affected in optic cup development. The fourth group contains 13 mutants with defects in retinal differentiation. 12 of these have smaller eyes, whereas one mutation results in enlarged eyes. The fifth group consists of three mutants with defects in retinal pigmentation. The collection of mutants will be used to address the molecular genetic mechanisms underlying vertebrate eye formation.
authors.affiliation: European Molecular Biology Laboratory, Developmental Biology Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
authors.forename: Felix
authors.initials: F
authors.lastname: Loosli
authors.forename: Filippo
authors.initials: F
authors.lastname: Del Bene
authors.forename: Rebecca
authors.initials: R
authors.lastname: Quiring
authors.forename: Martina
authors.initials: M
authors.lastname: Rembold
authors.forename: Juan-Ramon
authors.initials: JR
authors.lastname: Martinez-Morales
authors.forename: Matthias
authors.initials: M
authors.lastname: Carl
authors.forename: Clemens
authors.initials: C
authors.lastname: Grabher
authors.forename: Caroline
authors.initials: C
authors.lastname: Iquel
authors.forename: Annette
authors.initials: A
authors.lastname: Krone
authors.forename: Beate
authors.initials: B
authors.lastname: Wittbrodt
authors.forename: Sylke
authors.initials: S
authors.lastname: Winkler
authors.forename: Takao
authors.initials: T
authors.lastname: Sasado
authors.forename: Chikako
authors.initials: C
authors.lastname: Morinaga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suwa
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Niwa
authors.forename: Thorsten
authors.initials: T
authors.lastname: Henrich
authors.forename: Tomonori
authors.initials: T
authors.lastname: Deguchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Hirose
authors.forename: Norimasa
authors.initials: N
authors.lastname: Iwanami
authors.forename: Sanae
authors.initials: S
authors.lastname: Kunimatsu
authors.forename: Masakazu
authors.initials: M
authors.lastname: Osakada
authors.forename: Tomomi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Akihito
authors.initials: A
authors.lastname: Yasuoka
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yoda
authors.forename: Christoph
authors.initials: C
authors.lastname: Winkler
authors.forename: Harun
authors.initials: H
authors.lastname: Elmasri
authors.forename: Hisato
authors.initials: H
authors.lastname: Kondoh
authors.forename: Makoto
authors.initials: M
authors.lastname: Furutani-Seiki
authors.forename: Joachim
authors.initials: J
authors.lastname: Wittbrodt
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D005808:Genes, Recessive; D009990:Oryzias / Q000196:embryology* / Q000235:genetics*; D010858:Pigmentation / Q000235:genetics; D012160:Retina / Q000166:cytology / Q000196:embryology*