title: Incidence of cytomegalovirus reactivation in patients with inflammatory connective tissue diseases who are under immunosuppressive therapy.
abstract: OBJECTIVE
  To evaluate the incidence and effect of cytomegalovirus (CMV) reactivation in patients with inflammatory connective tissue diseases (CTD) undergoing immunosuppressive therapy.
  
  
  METHODS
  A total of 18 consecutive CMV seropositive patients undergoing immunosuppressive therapy for inflammatory CTD were enrolled. CMV reactivation was determined by detection of CMV-DNA in peripheral blood leukocytes (PBL) or plasma using quantitative real-time polymerase chain reaction.
  
  
  RESULTS
  CMV reactivation was detected in PBL in 7 of 17 evaluable patients (41%), and in plasma in 5 of 17 patients (29%). Patients with detectable CMV-DNA in plasma were exclusively positive for CMV-DNA in PBL. Conclusion. Patients with inflammatory CTD under immunosuppressive therapy are at high risk for CMV reactivation. The clinical significance of such an event and indications for antiviral therapy should be examined further.
authors.affiliation: Second Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, Kawagoe, Saitama, Japan. tmori@sc.itc.keio.ac.jp
authors.forename: Takehiko
authors.initials: T
authors.lastname: Mori
authors.forename: Hideto
authors.initials: H
authors.lastname: Kameda
authors.forename: Hiroe
authors.initials: H
authors.lastname: Ogawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Iizuka
authors.forename: Naoya
authors.initials: N
authors.lastname: Sekiguchi
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Takei
authors.forename: Hayato
authors.initials: H
authors.lastname: Nagasawa
authors.forename: Michihide
authors.initials: M
authors.lastname: Tokuhira
authors.forename: Toshio
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Saito
authors.forename: Koichi
authors.initials: K
authors.lastname: Amano
authors.forename: Toru
authors.initials: T
authors.lastname: Abe
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000328:Adult; D000368:Aged; D003240:Connective Tissue Diseases / Q000150:complications* / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007154:Immune System Diseases / Q000150:complications / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D007166:Immunosuppressive Agents