A new alkaloid from Dysoxylum binectariferum.
Two compounds (1 and 2) have been isolated from the stem bark of Dysoxylum binectariferum (Roxb.) Hook. f. ex Bedd. Compound 1 is rohitukine [5,7-dihydroxy-2-methyl-8-[4-(3-hydroxy-1- methyl)-piperidinyl]-4H-1-benzopyran-4-one], a known compound that has anti-inflammatory and immunomodulatory activities. Compound 2 is a new alkaloid, named rohitukine N-oxide, the structure of which was elucidated on the basis of spectral evidences and comparison with the 1H NMR data of rohitukine.
Yang
Dong-Hui
DH
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.
Cai
Shao-Qing
SQ
Zhao
Yu-Ying
YY
Liang
Hong
H
D000470:Alkaloids / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry*; D018547:Plant Stems
D000470:Alkaloids; D010936:Plant Extracts