Water-soluble polymers with low critical solution temperature (LCST) as carriers for protein drug delivery.
The copolymers of N,N-diethylacrylamide and ovomucoid from duck egg white (an inhibitor of proteolytic enzymes) with low critical solution temperature (LCST) have been synthesized. The behaviour of these copolymers at the point of phase transition was investigated. It was shown that the relation between LCST and physiological activity for these copolymers is a function of their composition. The increase of ovomucoid content leads to the increase of LCST. When the content of ovomucoid rises above 0.2 mol%, LCST disappears. At the same time the physiological activity of obtained copolymers decrease with increasing of N,N-diethylacrylamide content.
Plate
Nicolai A
NA
Institute of Petrochemical Synthesis, Russian Academy of Sciences, 29 Leninsky prospect, 119991 Moscow, Russia.
Valuev
Ivan L
IL
Valuev
Lev I
LI
D000178:Acrylamides; D004337:Drug Carriers / Q000737:chemistry*; D005782:Gels; D010059:Ovomucin / Q000008:administration & dosage; D044367:Phase Transition; D011108:Polymers / Q000627:therapeutic use; D011506:Proteins / Q000008:administration & dosage*; D012995:Solubility; D013329:Structure-Activity Relationship; D013696:Temperature; D014867:Water
D000178:Acrylamides; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; D011506:Proteins; C428028:poly(N,N-diethylacrylamide); D014867:Water; D010059:Ovomucin