title: In vitro interactions of approved and novel drugs against Paecilomyces spp.
abstract: We have evaluated the in vitro activity of 15 combinations of antifungal drugs (amphotericin B, itraconazole, voriconazole, albaconazole, ravuconazole, terbinafine, and micafungin) against four isolates of Paecilomyces variotii and three of P. lilacinus. The interaction of terbinafine with the four azoles was synergistic for 53% of the combinations, while the interactions of both amphotericin B and micafungin with the rest of antifungal agents were mainly indifferent.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21.43201 Reus, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Ortoneda
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Isabel
authors.initials: I
authors.lastname: Pujol
authors.forename: Clara
authors.initials: C
authors.lastname: Yustes
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology; D009281:Naphthalenes / Q000494:pharmacology; D010143:Paecilomyces / Q000187:drug effects*; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine