title: 123I-beta-CIT binding and recovery from depression. A six-month follow-up study.
abstract: Eighteen depressive outpatients were investigated using single-photon emission computerized tomography (SPECT) with a high-affinity dopamine (DA) and serotonin transporter (SERT) specific radioligand, (123)I-labeled beta-CIT (2 beta-carbomethoxy-3 beta-(4-iodophenyl)-tropane). The patients were tested at the beginning of the study and on follow-up after six months. The severity of depression was evaluated using the 17-item Hamilton Rating Scale of Depression (HRSD). Eight of the eighteen patients had an HRSD score below the median (12 points) on follow-up, and they had a significantly greater increase in (123)I-beta-CIT binding in the midbrain region compared with those patients who did not recover (ANCOVA: F = 8.12; df = 1, 14; p = 0.013). These results indicate that recovery from depression is associated with an increase in (123)I-beta-CIT binding in the midbrain.
authors.affiliation: Mental Health Center, Armilankatu 44, 53100 Lappeenranta, Finland. teijamari.laasonen-balk@lappeenranta.fi
authors.forename: Teijamari
authors.initials: T
authors.lastname: Laasonen-Balk
authors.forename: Heimo
authors.initials: H
authors.lastname: Viinamäki
authors.forename: Jyrki T
authors.initials: JT
authors.lastname: Kuikka
authors.forename: Minna
authors.initials: M
authors.lastname: Husso-Saastamoinen
authors.forename: Johannes
authors.initials: J
authors.lastname: Lehtonen
authors.forename: Jari
authors.initials: J
authors.lastname: Tiihonen
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001923:Brain Chemistry; D003042:Cocaine / Q000031:analogs & derivatives; D003863:Depression / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007456:Iodine Isotopes; D008297:Male; D008609:Mental Status Schedule; D008636:Mesencephalon / Q000000981:diagnostic imaging*; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D007456:Iodine Isotopes; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine