title: Therapeutic amniocentesis for treatment of twin-twin transfusion syndrome.
abstract: OBJECTIVE
  The objective was to determine whether therapeutic amniocentesis may improve outcomes in patients with twin-twin transfusion syndrome.
  
  
  METHODS
  Eleven patients were managed aggressively with repetitive serial amniocenteses, and six patients were managed conservatively.
  
  
  RESULTS
  The time interval between diagnosis and delivery was 17.4 days more in the amniodrainage group, but the difference between the groups was not significant (68.3+/-41.9 days in the therapeutic amniocentesis group and 50.83+/-29.7 days in the expectant management group [p=0.384]). The overall survival rate of the two groups was 38.2%, and was not significantly different between groups (40.9% in the amniocentesis group and 33.3% in the expectant management group; p=1.00). Two of nine (22.2%) infants in the amnioreduction group, and one of four (25.0%) infants in the expectantly managed group had neurological symptoms.
  
  
  CONCLUSIONS
  Our results did not show a significant benefit of aggressive therapeutic amniocentesis. A slight improvement in perinatal outcome was observed.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Istanbul, 7-8 Kisim Marti Sitesi 2. Blok Daire 16, 34750 Istanbul, Turkey. recephas@superonline.com
authors.forename: Recep
authors.initials: R
authors.lastname: Has
authors.forename: Suleyman
authors.initials: S
authors.lastname: Akhan
authors.forename: Samet
authors.initials: S
authors.lastname: Topuz
authors.forename: Hayri
authors.initials: H
authors.lastname: Ermiş
authors.forename: Cem
authors.initials: C
authors.lastname: Iyibozkurt
authors.forename: Lem'i
authors.initials: L
authors.lastname: Ibrahimoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000649:Amniocentesis / Q000379:methods*; D005260:Female; D005330:Fetofetal Transfusion / Q000628:therapy*; D005865:Gestational Age; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome