title: Sentinel lymph node detection in primary melanoma with preoperative dynamic lymphoscintigraphy and intraoperative gamma probe guidance.
abstract: BACKGROUND
  This study assessed the value of the radioisotopic method used alone, and factors influencing relapse rates, for sentinel lymph node (SLN) mapping in primary melanoma.
  
  
  METHODS
  One hundred and thirty-three patients with a diagnosis of melanoma (thickness greater than 0.75 mm) underwent gamma probe-directed lymphatic mapping in a prospective single-centre study.
  
  
  RESULTS
  Mean Breslow thickness was 3 mm. At least one SLN was identified in 132 patients (mean 1.8 nodes per patient); the success rate was 99.2 per cent. Twenty-two patients (16.7 per cent) had a metastasis within the SLN. The mean tumour thickness in patients with a metastatic SLN was 4.4 mm compared with 2.7 mm for patients with a negative SLN (P < 0.001). The median time to recurrence was 20.4 months in SLN-negative patients compared with 8.5 months in those with SLN metastasis (P < 0.001). Ten (9.1 per cent) of the 110 SLN-negative patients developed recurrence. Three patients relapsed in the previously mapped lymphatic basin after a median follow-up of 27.1 months.
  
  
  CONCLUSIONS
  This study confirmed the reliability and accuracy of SLN mapping using a radioisotope technique, and also the importance of the SLN as a predictive factor for survival. There was a low risk of locoregional recurrence when the SLN was not involved.
authors.affiliation: Department of General and Thoracic Surgery, Hôpital Nord, Saint Etienne, France. olivier.tiffet@chu-st-etienne.fr
authors.forename: O
authors.initials: O
authors.lastname: Tiffet
authors.forename: J L
authors.initials: JL
authors.lastname: Perrot
authors.forename: A
authors.initials: A
authors.lastname: Gentil-Perret
authors.forename: N
authors.initials: N
authors.lastname: Prevot
authors.forename: F
authors.initials: F
authors.lastname: Dubois
authors.forename: E
authors.initials: E
authors.lastname: Alamartine
authors.forename: F
authors.initials: F
authors.lastname: Cambazard
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007430:Intraoperative Care; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy / Q000379:methods; D012867:Skin / Q000473:pathology*; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome