Dihydroethanoanthracene derivatives as in vitro malarial chloroquine resistance reversal agents.
The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24 chloroquine-resistant and 10 chloroquine-susceptible strains of Plasmodium falciparum from different countries. The 9,10-dihydroethanoanthracene derivatives clearly increase chloroquine susceptibility only in chloroquine-resistant isolates.
Millet
Julie
J
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Boulevard Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France.
Torrentino-Madamet
Marylin
M
Alibert
Sandrine
S
Rogier
Christophe
C
Santelli-Rouvier
Christiane
C
Mosnier
Joel
J
Baret
Eric
E
Barbe
Jacques
J
Parzy
Daniel
D
Pradines
Bruno
B
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D006801:Humans; D016778:Malaria, Falciparum / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000873:Anthracenes; D000962:Antimalarials; D001952:Bridged-Ring Compounds; D002738:Chloroquine