title: Outcome analysis of major cardiac operations in low weight neonates.
abstract: BACKGROUND
  From June 1995 to January 2003, 49 consecutive neonates of less than 2,500 g underwent early surgery for congenital heart disease. A retrospective analysis was performed to evaluate the early to medium term outcome.
  
  
  METHODS
  Major cardiac surgery for congenital heart defects included a complete correction in 31 patients (group I) and a palliative procedure in 18 patients (group II). Mean age at operation was 15.2 days (1 day-90 days) and mean weight was 2,190 g (1,300 g-2,500 g). Twenty-four children (49%) were born prematurely. All neonates were critically ill and 47% were already ventilated preoperatively. Heart defects included mainly ventricular septal defect (10), tetralogy of Fallot complexes (8), aortic coarctation (8), transposition complexes (7), single ventricle anomalies (4), pulmonary atresia with intact septum (4), interrupted aortic arch (3), totally anomalous pulmonary venous return (3), and common atrioventricular septal defect (2).
  
  
  RESULTS
  Overall surgical mortality was 18%: 4 neonates died after definitive repair and 5 after palliation; representing, respectively, 13% and 28% of each group. Postoperative morbidity occurred in half of the patients (53%). Age, weight, prematurity, type of first surgical procedure, and use of cardiopulmonary bypass did not influence the early outcome. After a mean follow-up of 2.82 years (2 months to 6 years), survival was 87% in the correction group and 54% in the palliation group. All children were in NYHA class I-II. Freedom from reintervention at 18 months was 68% after correction versus 8% after palliation.
  
  
  CONCLUSIONS
  Cardiac surgery for congenital malformations in critically ill, low weight neonates can be achieved with acceptable mortality, at the cost of an increased morbidity. Early outcome seems independent of age, weight, prematurity, use of extracorporeal perfusion, and type of first intervention. Moreover, primary correction appears to result in an early survival benefit, remaining constant over time.
authors.affiliation: Department of Cardiac Surgery, University Hospital of Gent, Ghent, Belgium. thierry.bove@ugent.be
authors.forename: Thierry
authors.initials: T
authors.lastname: Bové
authors.forename: Katrien
authors.initials: K
authors.lastname: François
authors.forename: Katya
authors.initials: K
authors.lastname: De Groote
authors.forename: Bert
authors.initials: B
authors.lastname: Suys
authors.forename: Daniel
authors.initials: D
authors.lastname: De Wolf
authors.forename: Hendrik
authors.initials: H
authors.lastname: Verhaaren
authors.forename: Dirk
authors.initials: D
authors.lastname: Matthys
authors.forename: Annelies
authors.initials: A
authors.lastname: Moerman
authors.forename: Jan
authors.initials: J
authors.lastname: Poelaert
authors.forename: Piet
authors.initials: P
authors.lastname: Vanhaesebroeck
authors.forename: Guido
authors.initials: G
authors.lastname: Van Nooten
mesh_terms: D001724:Birth Weight; D006348:Cardiac Surgical Procedures / Q000401:mortality / Q000706:statistics & numerical data*; D002315:Cardiopulmonary Bypass / Q000706:statistics & numerical data; D016638:Critical Illness; D005260:Female; D005865:Gestational Age; D006330:Heart Defects, Congenital / Q000401:mortality / Q000601:surgery*; D017052:Hospital Mortality; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008607:Intellectual Disability / Q000453:epidemiology; D008297:Male; D010166:Palliative Care; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome