Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.
Verburg
F A
FA
Department of Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. e.verburg@azu.nl
Lips
C J M
CJ
Lentjes
E G W M
EG
de Klerk
J M H
JM
D018263:Adenocarcinoma, Follicular / Q000097:blood* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000097:blood* / Q000235:genetics / Q000473:pathology; D005500:Follow-Up Studies; D020869:Gene Expression Profiling; D006801:Humans; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D012333:RNA, Messenger / Q000097:blood*; D012334:RNA, Neoplasm / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013954:Thyroglobulin / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000097:blood* / Q000473:pathology
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D013954:Thyroglobulin