[Supplementation with micronutrients attenuating stress injuries in rats].
OBJECTIVE
To observe the protective effects of compound micronutrients (CMN) on stress-induced injury of the rats.


METHODS
The experimental rats were fed with diet added micronutrients in small, medium and large dose respectively. The stress animal model was established by feet-electric shock. The behaviors in open-field test, hormons, metallothionein (MT) and the antioxidant ability of the rats were detected.


RESULTS
Compared with control group, the abnormal behaviors in open-field test, increased cortisol level in serum, decreased epinephrine and norepinephrine contents in brain were observed in stress rats. Also stress induced significantly changes of MT levels in liver and brain, and declined antioxidant ability in serum and enhanced lipid peroxidation in liver of the animals. The most indicators mentioned above were obviously improved by supplementation with CMN for 6 weeks.


CONCLUSIONS
Supplementation with CMN was beneficial to improve the stress adapting ability and to attenuate the stress-induced injuries in rats.
Cheng
Yiyong
Y
Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China.
Wang
Donglan
D
Li
Shutian
S
Geng
Zhanhui
Z
D000596:Amino Acids / Q000627:therapeutic use; D000818:Animals; D004558:Electric Stimulation; D004837:Epinephrine / Q000378:metabolism; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D018977:Micronutrients / Q000627:therapeutic use*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D014131:Trace Elements / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*
D000596:Amino Acids; D018977:Micronutrients; D014131:Trace Elements; D014815:Vitamins; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine