title: Getting more from IR-microscopy of resin-bound libraries.
abstract: A linear pixel-array detector was employed to create spatially resolved multi-layered IR-images of a large collection of polymer beads supporting carbonyl and nitrile monomers. The feasibility of creating multi-layered IR-images with nitrile IR-band separation of 4 cm(-1) was demonstrated, an important issue when considering that many monomers used to develop combinatorial libraries are structurally analogous and therefore occupy very similar positions in the IR-spectrum. Strategies for obtaining high quality spectral data from both imaging and mapping IR-microscopes without compromising on sample area, analysis time, or spatial resolution are also described.
authors.affiliation: Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.
authors.forename: Gurjit S
authors.initials: GS
authors.lastname: Mandair
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Russell
authors.forename: Gavin
authors.initials: G
authors.lastname: Aston
authors.forename: Mark
authors.initials: M
authors.lastname: Bradley
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007091:Image Processing, Computer-Assisted; D012117:Resins, Synthetic / Q000737:chemistry*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods*
chemical_list: D012117:Resins, Synthetic