[Hypoglycemic effects of bis(maltolato)oxovanadium administered by different routes upon diabetic rats].
OBJECTIVE
To study the hypoglycemic effects of bis(maltolato) oxovanadium (IV) (BMOV) after administration on diabetic rats by different routines, and its possible mechanisms.


METHODS
Diabetic rats were created by intraperitoneal administration of Alloxan. BMOV was administered by single intraperitoneal injection, oral gavage, subcutaneous injection, bolus intravenous injection, or slow bolus intravenous injection(7-8 min). Plasma glucose levels were determined with blood glucose assay kits using the glucose oxidase method, while the plasma insulin concentrations were monitored by the insulin assay kits using Radioimmunoasssay (RIA) method.


RESULTS
Plasma glucose levels were significantly decreased after administration of BMOV by all routes except intravenous injection. Food and fluid intake by the diabetic rats were also reduced. There was no significant increase in plasma insulin concentration.


CONCLUSIONS
BMOV administered by oral gavage, subcutaneous injection and intraperitoneal injection has obvious effect of decreasing plasma glucose levels on diabetic rats, and the hypoglycemic effect of BMOV was not achieved by increasing the plasma insulin concentration.
Zhong
Xu-ying
XY
Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Zhang
Hua
H
Zhang
Xuan
X
Lv
Wan-liang
WL
Zhang
Qiang
Q
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood; D008297:Male; D011753:Pyrones / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D014638:Vanadates / Q000008:administration & dosage*
D007004:Hypoglycemic Agents; D007328:Insulin; D011753:Pyrones; C074212:bis(maltolato)oxovanadium(IV); D014638:Vanadates; D000496:Alloxan