Compression of pellets coated with various aqueous polymer dispersions.
Pellets coated with a new aqueous polyvinyl acetate dispersion, Kollicoat SR 30 D, could be compressed into tablets without rupture of the coating providing unchanged release profiles. In contrast, the compression of pellets coated with the ethylcellulose dispersion, Aquacoat ECD 30, resulted in rupture of the coating and an increase in drug release. Plasticizer-free Kollicoat SR coatings were too brittle and ruptured during compression. The addition of only 10% w/w triethyl citrate as plasticizer improved the flexibility of the films significantly and allowed compaction of the pellets. The drug release was almost independent of the compression force and the pellet content of the tablets. The inclusion of various tabletting excipients slightly affected the drug release, primarily because of a different disintegration rate of the tablets. The core size of the starting pellets had no influence on the drug release. Pellets coated with the enteric polymer dispersion Kollicoat 30 D MAE 30 DP [poly(methacrylic acid, ethyl acrylate) 1:1] lost their enteric properties after compression because of the brittle properties of this enteric polymer. Coating of pellets with a mixture of Kollicoat MAE 30 DP and Kollicoat EMM 30 D [poly(ethyl acrylate, methyl methacrylate) 2:1] at a ratio of 70/30 and compaction of the pellets resulted in sufficient enteric properties.
Dashevsky
A
A
College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, Berlin 12169, Germany. dashevsk@zedat.fu-berlin.de
Kolter
K
K
Bodmeier
R
R
D000180:Acrylic Resins / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003102:Colloids; D003692:Delayed-Action Preparations / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010968:Plasticizers / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000737:chemistry*; D013608:Tablets, Enteric-Coated / Q000737:chemistry
D000180:Acrylic Resins; D003102:Colloids; D003692:Delayed-Action Preparations; D005079:Excipients; D008689:Methacrylates; D010968:Plasticizers; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D013607:Tablets; D013608:Tablets, Enteric-Coated; C117135:kollicoat MAE 30 D; C492994:poly(ethyl acrylate-methyl methacrylate); C013215:polyvinyl acetate; C013517:ethyl cellulose; D002482:Cellulose