Conserved RNA secondary structures in viral genomes: a survey.
The genomes of RNA viruses often carry conserved RNA structures that perform vital functions during the life cycle of the virus. Such structures can be detected using a combination of structure prediction and co-variation analysis. Here we present results from pilot studies on a variety of viral families performed during bioinformatics computer lab courses in past years.
Hofacker
I L
IL
Institut für Theoretische Chemie und Molekulare Strukturbiologie, Universität Wien, Währingerstrasse 17, Vienna, A-1090, Austria. ivo@tbi.univie.ac.at
Stadler
P F
PF
Stocsits
R R
RR
D000465:Algorithms; D003198:Computer Simulation; D017124:Conserved Sequence / Q000235:genetics*; D030541:Databases, Genetic; D016679:Genome, Viral; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D012367:RNA, Viral / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods; D017423:Sequence Analysis, RNA / Q000379:methods*
D012367:RNA, Viral