title: Angioedema related to the use of hyaluronidase in cataract surgery.
abstract: OBJECTIVE
  To report a series of cases of angioedema related to the use of hyaluronidase in cataract surgery.
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  Three eyes of three patients who had periorbital angioedema after phacoemulsification at the Mayo Clinic, Rochester, Minnesota, between April 2001 and May 2002 were retrospectively skin tested for allergies using the prick technique.
  
  
  RESULTS
  Skin testing was positive in all three patients for allergy to hyaluronidase (150 U/cc) and histamine control; and negative for prick control, 2% lidocaine, 1% cyclopentolate, 2.5% neosynephrine, 0.5% proparacaine, 0.3% ofloxacin, and thimerosal.
  
  
  CONCLUSIONS
  The use of hyaluronidase in ophthalmic anesthesia injection may cause immediate type hypersensitivity reactions such as angioedema.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: Anne H
authors.initials: AH
authors.lastname: Eberhart
authors.forename: Catherine R
authors.initials: CR
authors.lastname: Weiler
authors.forename: Jay C
authors.initials: JC
authors.lastname: Erie
mesh_terms: D000799:Angioedema / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000009:adverse effects*; D007428:Intradermal Tests; D009916:Orbital Diseases / Q000139:chemically induced*; D018918:Phacoemulsification
chemical_list: D006821:Hyaluronoglucosaminidase