title: Cerebral sinus thrombosis associated with severe active ulcerative colitis.
abstract: A 19-year-old man with severe active ulcerative colitis was admitted to our hospital where he was prescribed 80 mg prednisolone and underwent leukocytapheresis (LCAP). Two weeks after initiating therapy, his symptoms had not recovered. We administered cyclosporin via continuous intravenous infusion for 12 days. Although his clinical symptoms improved, he complained of severe headache. Immediate plain computed tomography (CT) and magnetic resonance imaging angiography (MRA) revealed extensive thrombosis in the superior sagittal sinus and right transverse sinus. We treated this condition with the anticoagulant agent, heparin, which prevents and can treat venous thrombosis. We report an occurrence of cerebral sinus thrombosis accompanying ulcerative colitis, where active anticoagulant therapy was useful.
authors.affiliation: First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1601.
authors.forename: Shizuka
authors.initials: S
authors.lastname: Murata
authors.forename: Naoto
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Shoutaro
authors.initials: S
authors.lastname: Oshikawa
authors.forename: Junichi
authors.initials: J
authors.lastname: Yamaga
authors.forename: Masaaki
authors.initials: M
authors.lastname: Ootsuka
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Date
authors.forename: Michitaka
authors.initials: M
authors.lastname: Kitani
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Inatsu
authors.forename: Tanenao
authors.initials: T
authors.lastname: Eto
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D003131:Combined Modality Therapy; D016572:Cyclosporine / Q000008:administration & dosage; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D007937:Leukapheresis / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D011856:Radiographic Image Enhancement; D018570:Risk Assessment; D012720:Severity of Illness Index; D012812:Sigmoidoscopy / Q000379:methods; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D015912:Thrombolytic Therapy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
chemical_list: D016572:Cyclosporine; D006493:Heparin; D011239:Prednisolone