title: Resolution of AIDS-related Castleman's disease with anti-CD20 monoclonal antibodies is associated with declining IL-6 and TNF-alpha levels.
abstract: A 32-year-old HIV-1 positive man was diagnosed with Castleman's disease following a long history of constitutional symptoms. Primary therapy with single agent rituximab was associated with a near complete response. During this time, his KSHV (Kaposi's sarcoma-associated herpesvirus) viral load decreased and we also observed immediate, large and sustained decreases in interleukin-6 (IL-6) and tumor necrosis factor-alpha levels (TNF-alpha). This highlights the close association between circulating cytokines such as IL-6 and virally-induced malignancy.
authors.affiliation: Departments of Oncology & HIV Medicine, Chelsea & Westminster Hospital, London SW10 9NH, UK.
authors.forename: Tom
authors.initials: T
authors.lastname: Newsom-Davis
authors.forename: Mark
authors.initials: M
authors.lastname: Bower
authors.forename: Adrian
authors.initials: A
authors.lastname: Wildfire
authors.forename: Christina
authors.initials: C
authors.lastname: Thirlwell
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
authors.forename: Brian
authors.initials: B
authors.lastname: Gazzard
authors.forename: Justin
authors.initials: J
authors.lastname: Stebbing
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D000328:Adult; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20 / Q000276:immunology*; D005871:Castleman Disease / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D007167:Immunotherapy; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008297:Male; D000069283:Rituximab; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D018951:Antigens, CD20; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000069283:Rituximab