title: [Loss of consciousness in a child due to loperamide].
abstract: Loperamide is an antidiarrheal peripheral opiate agonist, with rare neurological secondary effects. We report the case of a 26-month-old child who had impaired consciousness under treatment by loperamide, and was treated successfully with naloxone. Limitations of the use of loperamide in young children are underlined. Naloxone may be used in case of impaired consciousness, for a diagnostic as well as therapeutic purpose.
authors.affiliation: Service de pédiatrie et néonatologie, centre hospitalier d'Orsay, BP 27, 91401 Orsay, France. s.chanzy@ch-orsay.fr
authors.forename: S
authors.initials: S
authors.lastname: Chanzy
authors.forename: S
authors.initials: S
authors.lastname: Moretti
authors.forename: H
authors.initials: H
authors.lastname: Mayet
authors.forename: M C
authors.initials: MC
authors.lastname: Routon
authors.forename: C
authors.initials: C
authors.lastname: De Gennes
authors.forename: J C
authors.initials: JC
authors.lastname: Msélati
mesh_terms: D000930:Antidiarrheals / Q000009:adverse effects* / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008139:Loperamide / Q000009:adverse effects* / Q000627:therapeutic use*; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D014474:Unconsciousness / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000930:Antidiarrheals; D009292:Narcotic Antagonists; D009270:Naloxone; D008139:Loperamide