title: School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10-12 years in Beijing.
abstract: A 2-year milk intervention trial was carried out with 757 girls, aged 10 years, from nine primary schools in Beijing (April 1999 - March 2001). Schools were randomised into three groups: group 1, 238 girls consumed a carton of 330 ml milk fortified with Ca on school days over the study period; group 2, 260 girls received the same quantity of milk additionally fortified with 5 or 8 microg cholecalciferol; group 3, 259 control girls. Anthropometric and bone mineralisation measurements, as well as dietary, health and physical-activity data, were collected at baseline and after 12 and 24 months of the trial. Over the 2-year period the consumption of this milk, with or without added cholecalciferol, led to significant increases in the changes in height (> or =0.6 %), sitting height (> or =0.8 %), body weight (> or 2.9 %), and (size-adjusted) total-body bone mineral content (> or =1.2 %) and bone mineral density (> or =3.2 %). Those subjects receiving additional cholecalciferol compared with those receiving the milk without added 25-hydoxycholecalciferol had significantly greater increases in the change in (size-adjusted) total-body bone mineral content (2.4 v. 1.2 %) and bone mineral density (5.5 v. 3.2 %). The milk fortified with cholecalciferol significantly improved vitamin D status at the end of the trial compared with the milk alone or control groups. It is concluded that an increase in milk consumption, e.g. by means of school milk programmes, would improve bone growth during adolescence, particularly when Ca intake and vitamin D status are low.
authors.affiliation: Faculty of Veterinary Science, The University of Sydney, NSW 2006, Australia. xdu@vetsci.usyd.edu.au
authors.forename: Xueqin
authors.initials: X
authors.lastname: Du
authors.forename: Kun
authors.initials: K
authors.lastname: Zhu
authors.forename: Angelika
authors.initials: A
authors.lastname: Trube
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Guansheng
authors.initials: G
authors.lastname: Ma
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Hu
authors.forename: David R
authors.initials: DR
authors.lastname: Fraser
authors.forename: Heather
authors.initials: H
authors.lastname: Greenfield
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001827:Body Height / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D001846:Bone Development / Q000502:physiology; D002112:Calcifediol / Q000008:administration & dosage; D002136:Calcium, Dietary / Q000008:administration & dosage; D002648:Child; D002681:China; D002762:Cholecalciferol / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake / Q000502:physiology; D005260:Female; D005527:Food, Fortified; D006128:Growth / Q000502:physiology*; D006801:Humans; D008892:Milk
chemical_list: D002136:Calcium, Dietary; D004044:Dietary Proteins; D002762:Cholecalciferol; D002112:Calcifediol