Multipoint recognition of basic proteins at a membrane model.
Cell surface recognition achieves high efficiency and specificity because of its polyvalent nature. A biomimetic model has been designed, which consists of a stearic acid monolayer with embedded calixarene tetraphosphonate receptor molecules. This system is able to distinguish between proteins of varying pI at nanomolar concentrations.
Zadmard
R
R
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
Arendt
M
M
Schrader
T
T
D047250:Calixarenes; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D011083:Polycyclic Compounds / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry; D013499:Surface Properties
D008055:Lipids; D008565:Membrane Proteins; D011083:Polycyclic Compounds; D013229:Stearic Acids; D047250:Calixarenes