EBV-positive Burkitt lymphoma as a late-onset posttransplantion lymphoproliferative disorder after allogeneic stem cell transplantation.
Posttransplantation lymphoproliferative disorder (PTLD) is one of the well-recognized complications after allogeneic stem cell transplantation (SCT). It generally occurs early after SCT, and only a few reports of late-onset cases are available. We report a 58-year-old male patient who developed lymphoma 4 years after allogeneic SCT for chronic myeloid leukemia. The presence of c-myc translocation and Epstein-Barr virus-encoded RNA in the lymphoma cells, without rearrangement of the 3'-bcr region, confirmed the histopathologic diagnosis of Burkitt lymphoma. DNA chimerism analysis revealed that the lymphoma cells were of donor origin. The patient achieved complete response with intensive chemotherapy. To our knowledge, this is the first report of Burkitt lymphoma as a PTLD occurring after allogeneic SCT.
Sekiguchi
Naohiro
N
Hematology Division, National Cancer Center Hospital, Tokyo, Japan.
Nishimoto
Junko
J
Tanosaki
Ryuji
R
Kubota
Nobuko
N
Yokota
Yukiko
Y
Kobayashi
Yukio
Y
Watanabe
Takashi
T
Kami
Masahiro
M
Takaue
Yoichi
Y
Matsuno
Yoshihiro
Y
Tobinai
Kensei
K
D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014019:Tissue Donors; D018183:Transplantation Chimera; D014184:Transplantation, Homologous / Q000009:adverse effects