title: Cutaneous Alternaria infection in renal transplant recipients: a report of two cases with an unusual mode of transmission.
abstract: We report two cases of cutaneous alternariosis in renal transplant recipients. The diagnosis was made by mycologic and histologic examination. The patients were treated with itraconazole. In one patient who had undergone surgical resection of the cutaneous lesion along with antifungal treatment, the follow-up period was uneventful with no signs of recurrence. In the other patient, surgical excision of the lesion was not performed prior to antifungal therapy. The lesion disappeared following treatment but local recurrence was observed 1.5 years later with an unfavorable evolution despite administration of the second course of therapy. Resection of the lesion and prolongation of the treatment resulted in a satisfactory course with no signs of local recurrence over a follow-up period of 4.5 years. Interestingly, both of the patients had a previous history of a mild traumatic event with a stretcher in our outpatient clinic where the follow-up visits were made. A vast mycologic survey was then made in our department, which disclosed that some of the stretchers were contaminated by the fungi and could have potentially served as the reservoirs and vectors for the transmission of the fungus.
authors.affiliation: Department of Nephrology and Renal Transplantation, Saint-Jacques University Hospital, 25000 Besançon, France. akazory@chu-besancon.fr
authors.forename: A
authors.initials: A
authors.lastname: Kazory
authors.forename: D
authors.initials: D
authors.lastname: Ducloux
authors.forename: G
authors.initials: G
authors.lastname: Reboux
authors.forename: D
authors.initials: D
authors.lastname: Blanc
authors.forename: B
authors.initials: B
authors.lastname: Faivre
authors.forename: J-M
authors.initials: JM
authors.lastname: Chalopin
authors.forename: R
authors.initials: R
authors.lastname: Piarroux
mesh_terms: D000328:Adult; D000528:Alternaria / Q000302:isolation & purification*; D003428:Cross Infection / Q000382:microbiology / Q000635:transmission*; D003881:Dermatomycoses / Q000382:microbiology / Q000635:transmission*; D004866:Equipment Contamination; D004865:Equipment and Supplies, Hospital / Q000382:microbiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged