Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation.
This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.
Healey
Kathleen M
KM
Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Pavletic
Steven Z
SZ
Al-Omaishi
Jinan
J
Leuschen
M Patricia
MP
Pirruccello
Samuel J
SJ
Filipi
Mary L
ML
Enke
Charles
C
Ursick
Mary Margaret
MM
Hahn
Francis
F
Bowen
J D
JD
Nash
Richard A
RA
D000328:Adult; D004185:Disability Evaluation; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*; D009460:Neurologic Examination; D010865:Pilot Projects; D016896:Treatment Outcome
D007074:Immunoglobulin G