title: SEQUENTIAL HEMODYNAMIC STUDIES OF THE IONESCU-SHILEY PERICARDIAL XENOGRAFT VALVE UP TO SIX YEARS AFTER IMPLANTATION.
abstract: Sequential hemodynamic studies consisting of one preoperative and three postoperative cardiac catheterizations were undertaken in 19 patients at approximately 1, 4, and 6 years after valve replacement. Thirteen patients had aortic and six patients had mitral pericardial xenograft valves. Significant improvement was noted in various hemodynamic parameters in both groups of patients at the postoperative studies as compared to the preoperative findings. In patients with aortic valve replacement, the peak systolic gradient was 7.0 +/- 1.2 mm Hg at rest, and 10.0 +/- 1.6 mm Hg after exercise during the third postoperative study. The calculated xenograft orifice areas were 1.6 +/- 0.1 cm(2) at rest and 2.1 +/- 0.2 cm(2) after exercise in the aortic group, and 2.2 +/- 0.2 cm(2) at rest and 2.7 +/- 0.2 cm(2) after exercise in the mitral group at the third postoperative investigation. No significant change was noted among the three postoperative studies in the hemodynamic parameters. The results confirm the maintenance of functional performance of the Ionescu-Shiley pericardial xenograft up to 73 months after valve replacement.
authors.affiliation: Departments of Cardiology and Cardiothoracic Surgery, The General Infirmary, Leeds, England.
authors.forename: Anand P.
authors.initials: AP
authors.lastname: Tandon
authors.forename: Donald R.
authors.initials: DR
authors.lastname: Smith
authors.forename: Marian I.
authors.initials: MI
authors.lastname: Ionescu