title: Absorption of ethyl 2-cyanoacrylate tissue adhesive.
abstract: The aim of this study was to investigate absorption of ethyl 2-cyanoacrylate glue when used as a tissue adhesive. Ethyl 2-cyanoacrylate was applied subcutaneously to four rats; its presence in blood and urine was investigated by using High Pressure Liquid Chromatography. Blood samples were drawn at baseline and after 2, 4, 6, 24, 48, 54, 78, 96 hours following application. Urine samples were obtained at baseline and after 4, 24, 48, 72, 96 hours. Administration of ethyl 2-cyanoacrylate resulted in its absorption of unchanged ethyl 2-cyanoacrylate and unknown metabolites, in plasma and urine.
authors.affiliation: Department of Cardiovascular Surgery, Siyami Ersek Thoracic and Cardiovascular Surgery Center, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kaplan
authors.forename: Basak
authors.initials: B
authors.lastname: Oral
authors.forename: Sevim
authors.initials: S
authors.lastname: Rollas
authors.forename: Mustafa Sinan
authors.initials: MS
authors.lastname: Kut
authors.forename: Mahmut Murat
authors.initials: MM
authors.lastname: Demirtas
mesh_terms: D000042:Absorption; D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D003487:Cyanoacrylates / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013056:Spectrophotometry, Ultraviolet; D014014:Tissue Adhesives / Q000493:pharmacokinetics*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C029054:ethyl 2-cyanoacrylate