Cord blood cardiac troponin I as an early predictor of short-term outcome in perinatal hypoxia.
BACKGROUND
In most perinatal-hypoxia survivors, myocardial dysfunction can be reversed with appropriate inotropic support and oxygenation. The main problem related to outcome is cerebral damage.


OBJECTIVE
We tested the hypothesis that cardiac troponin I (cTnI), a known marker of myocardial injury, is also an early predictor of severity of cerebral damage and mortality in intrauterine hypoxia.


METHODS
Venous and arterial cord blood samples were collected at delivery from 54 consecutive newborns with hypoxic-ischemic encephalopathy and from 50 consecutive healthy controls. Arterial blood gas analysis was performed and levels of cTnI, creatine kinase and creatine kinase-MB in venous cord blood were measured. The same serum parameters were also measured on the 3rd and 7th day of life.


RESULTS
Infants with hypoxia had a significantly higher cord blood cTnI levels than controls (p < 0.0001). Cord blood and 3rd and 7th day serum cTnI values showed a significant increase with severity of HIE (p < 0.0001). In non-survivors cord blood cTnI levels were significantly higher than the survivors (5.9 ng/ml, range 2.1-12.8, and 1.6 ng/ml, range 0.4-5.8, respectively; p < 0.0001). Receiver-operator curve analysis revealed cord cTnI as the most sensitive factor for predicting early death (area under curve = 0.956; SE: 0.028; 95% CI: 0.9-1.01). Cord blood cTnI of 4.6 ng/ml was identified as the optimal cut-off level for predicting serious risk of early mortality.


CONCLUSIONS
The results suggest that significant elevation of cord cTnI is an excellent early predictor of severity of hypoxic-ischemic encephalopathy and mortality in term infants.
Türker
Gülcan
G
Neonatal Intensive Care Unit, Department of Pediatrics, Kocaeli University Hospital, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. glucanturker@superonline.com
Babaoğlu
Kadir
K
Gökalp
Ayşe S
AS
Sarper
Nazan
N
Zengin
Emine
E
Arisoy
Ayşe Engin
AE
D015415:Biomarkers / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000401:mortality*; D007231:Infant, Newborn; D007527:Isoenzymes / Q000097:blood; D011379:Prognosis; D012372:ROC Curve; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form