CART peptide increases the mesolimbic dopaminergic neuronal activity: a microdialysis study.
The effects of cocaine-and amphetamine-regulated transcript (CART) peptide on extracellular concentrations of dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in the shell region of the nucleus accumbens (AcbSh) were determined by microdialysis in conscious rats. Intracerebroventricular injections of various doses (0.1-5 microg/5 microl/rat) of CART(55-102) elicited dose-dependent increases of extracellular DOPAC and HVA concentration in the AcbSh, suggesting that CART(55-102) peptide has a psychostimulant-like effect via activation of the mesolimbic dopaminergic system.
Yang
Shu-Chuan
SC
Department of Physiology, School of Medicine, National Yang-Ming University, Taipei 112, Taiwan, ROC.
Pan
Jenn-Tser
JT
Li
Hui-Yun
HY
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007276:Injections, Intraventricular; D008032:Limbic System / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D017551:Microdialysis; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013268:Stimulation, Chemical; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein
D009419:Nerve Tissue Proteins; D000098882:Cocaine- and Amphetamine-Regulated Transcript Protein; D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine; D006719:Homovanillic Acid