Reference group choice and antibiotic resistance outcomes.
Two types of cohort studies examining patients infected with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) were contrasted, using different reference groups. Cases were compared to uninfected patients and patients infected with the corresponding, susceptible organism. VRE and MRSA were associated with adverse outcomes. The effect was greater when uninfected control patients were used.
Kaye
Keith S
KS
Duke University Medical Center, Durham, North Carolina 27710, USA. kaye0001@mc.duke.edu
Engemann
John J
JJ
Mozaffari
Essy
E
Carmeli
Yehuda
Y
D015331:Cohort Studies; D035061:Control Groups; D016983:Enterococcus; D006760:Hospitalization / Q000191:economics; D006801:Humans; D016106:Methicillin Resistance; D015999:Multivariate Analysis; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000191:economics; D013211:Staphylococcus aureus; D020713:Vancomycin Resistance; D014946:Wound Infection / Q000188:drug therapy* / Q000191:economics