PredictRegulon: a web server for the prediction of the regulatory protein binding sites and operons in prokaryote genomes.
An interactive web server is developed for predicting the potential binding sites and its target operons for a given regulatory protein in prokaryotic genomes. The program allows users to submit known or experimentally determined binding sites of a regulatory protein as ungapped multiple sequence alignments. It analyses the upstream regions of all genes in a user-selected prokaryote genome and returns the potential binding sites along with the downstream co-regulated genes (operons). The known binding sites of a regulatory protein can also be used to identify its orthologue binding sites in phylogeneticaly related genomes where the trans-acting regulator protein and cognate cis-acting DNA sequences could be conserved. PredictRegulon can be freely accessed from a link on our world wide web server: http://www.cdfd.org.in/predictregulon/.
Yellaboina
Sailu
S
Computational & Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad 500076, India.
Seshadri
Jayashree
J
Kumar
M Senthil
MS
Ranjan
Akash
A
D024506:5' Flanking Region; D001426:Bacterial Proteins / Q000235:genetics; D001665:Binding Sites; D016680:Genome, Bacterial; D020407:Internet; D009169:Mycobacterium tuberculosis / Q000235:genetics; D009876:Operon; D011387:Prokaryotic Cells / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D018085:Regulon; D016415:Sequence Alignment; D012697:Serine Endopeptidases / Q000235:genetics; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*; D000099160:LexA Repressor Protein
D001426:Bacterial Proteins; D012697:Serine Endopeptidases; D014157:Transcription Factors; D000099160:LexA Repressor Protein