[Insulin resistance syndrome in patients with gout and its influence on formation of clinical characteristics of the disease].
OBJECTIVE
To evaluate the occurrence of immunoresistance (IR) syndrome in gout and its correlation with a gout course.


METHODS
Anthropometric parameters, blood lipid spectrum, levels of glucose, uric acid (UA), immunoreactive insulin, HOMA index were studied in 55 male patients with gout (mean age 50.1 +/- 7.9 years, mean duration of the disease 7.5 +/- 7.2 years). Statistic processing was made with computer program Statistica 6.0.


RESULTS
IR was revealed in 49% patients. Immunoresistant patients had visceral obesity, arterial hypertension, abnormal lipid profile, high UA concentrations, longer disease, chronic articular syndrome, high occurrence of diabetes mellitus and vascular events significantly more frequently.


CONCLUSIONS
IR in gout patients is the risk factor of cardiovascular diseases; combination of IR and hyperinsulinemia is characterized by marked hyperuricemia and a trend to chronic course of the articular syndrome. Longer duration of gout, especially treated inadequately, raises the risk of IR. IR deteriorates prognosis in relation to cardiovascular diseases, diabetes mellitus type 2, course of gout itself.
Barskova
V G
VG
Eliseev
M S
MS
Nasonov
E L
EL
Iakunina
I A
IA
Zilov
A V
AV
Il'inykh
E V
EV
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology; D006073:Gout / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000378:metabolism; D033461:Hyperuricemia / Q000150:complications / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism; D012307:Risk Factors; D013577:Syndrome; D014527:Uric Acid / Q000032:analysis
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014527:Uric Acid