Foxp3: a critical regulator of the development and function of regulatory T cells.
Regulatory T cells are capable of suppressing deleterious immune responses against self- or non-self-antigens. Their essential role in tolerance and immune regulation has been illustrated by recent findings that mutations in the Foxp3 gene leads to the defective development of regulatory T cells and the emergence of a fatal autoimmune, inflammatory and allergic disease. This review discusses the critical role for this transcription factor in the development and function of regulatory T cells.
Hori
Shohei
S
Research Unit for Immune Homeostasis, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan. shohei@rcai.riken.jp
Sakaguchi
Shimon
S
D000818:Animals; D001327:Autoimmune Diseases; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D015536:Down-Regulation; D051858:Forkhead Transcription Factors; D006801:Humans; D006967:Hypersensitivity; D007108:Immune Tolerance; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology*
D004268:DNA-Binding Proteins; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse