Osteosarcoma as a second tumor after treatment for primary non-Hodgkin's lymphoma in a child with ataxia-telangiectasia: presentation of a case and review of possible pathogenetic mechanisms.
Patients with ataxia-telangiectasia (A-T) and cancer are exposed to additional toxicity due to their underlying inability to repair chemotherapy-induced DNA damage. The authors report the development of osteosarcoma as a second neoplasia in a child with A-T who was treated, without being irradiated, for non-Hodgkin's lymphoma as a primary malignancy. This is the first report of osteosarcoma associated with A-T. The authors postulate that the mechanisms of carcinogenesis are common and independent of the different histopathology categories of these two neoplasias, and the underlying "canvas" of the A-T mutated gene was further triggered by chemotherapy, leading to the development of a second malignancy.
Makis
Alexandros
A
Department of Pediatric Hematology/Oncology, Aghia Sophia Children's Hospital, Athens, Greece. me00350@cc.uoi.gr
Polychronopoulou
Sophia
S
Haidas
Stavros
S
D001260:Ataxia Telangiectasia / Q000150:complications*; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology*; D002648:Child; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000150:complications / Q000473:pathology*; D012516:Osteosarcoma / Q000150:complications / Q000473:pathology*