[Stem cells: biology and possible application to myocardial infarct].
If the heart fails to recover sufficient functionality following an infarct, then heart failure develops, an important cause of death in the western world. One obvious therapy is to create more muscle tissue to supplement the damaged myocardium with new functional contractile cells, together with neovasculogenesis. Stem cells repair recipient tissue by differentiating into tissue-specific cells or by creating an environment that stimulates the process of repair by the body's own cells at the site. In animal studies the heart function stabilised following an injection of stem cells in the infarcted area. In 3 non-randomised trials in humans, bone marrow stem cells were injected via the infarcted artery or round the infarcted area; the results indicated an improved heart function. There is currently still insufficient fundamental knowledge about the behaviour of multipotent cells, about the effects of using them for treatment, and about their long-term risk for these cells to be employed in the treatment of patients with a heart infarct.
Fijnvandraat
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Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Anatomie en Embryologie, Meibergdreef 15, 1105 AZ Amsterdam.
Moorman
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D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy*; D018919:Neovascularization, Physiologic; D012038:Regeneration / Q000502:physiology; D033581:Stem Cell Transplantation