A morphometric study of nucleolar organiser regions in cervical intraepithelial neoplasia.
The study sought a correlation between the number of AgNOR granules and the degree of cervical intraepithelial neoplasia (CIN). Thirty-five sections (5 normal, 10 CIN1, 10 CIN2 and 10 CIN3) were subjected to retrospective analysis. The percentage of cells with 1, 2, 3, 4 and more AgNORs was calculated and the number of granules per 100 cells was counted. The number of cells containing single granules decreases. However, the number increases with CIN level when the cells contain 4 and more AgNORs. The number of granules per 100 cells also increases with the degree of CIN. It can be thus concluded that the number of cells with 4 and more AgNOR granules can serve as a CIN differentiation exponent.
Terlikowski
Sławomir
S
Department of Pathophysiology of Pregnancy, Medical University, Białystok, Poland. ster@amb.edu.pl
Dziecioł
Janusz
J
Mazurek
Andrzej
A
Sulkowski
Stanisław
S
Boroń
Robert
R
Oniszczuk
Małgorzata
M
Lejmanowicz
Krzysztof
K
D001706:Biopsy; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009697:Nucleolus Organizer Region; D012189:Retrospective Studies; D016622:Silver Staining; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000235:genetics / Q000473:pathology*