Omeprazole and talampanel as two examples of retrometabolic drug design.
The goal of retrometabolic drug design is: "to design safe, locally active compounds with an improved therapeutic index". Here we describe two cases from our own practice, talampanel and omeprazole.
Andrási
F
F
IVAX Drug Research Institute, Budapest, Hungary.
Berzsenyi
P
P
Farkas
L
L
Körösi
J
J
Hámori
T
T
Botka
P
P
Ling
I
I
Láng
T
T
D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D007202:Indicators and Reagents; D009853:Omeprazole / Q000138:chemical synthesis* / Q000378:metabolism* / Q000494:pharmacology; D054328:Proton Pump Inhibitors; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D054328:Proton Pump Inhibitors; C061950:GYKI 52466; D001569:Benzodiazepines; C085266:talampanel; D009853:Omeprazole