title: [Usefulness of the sentinel node in the treatment and staging of initial cervix cancer].
abstract: OBJECTIVE
  The aim of this study was to evaluate the usefulness of intraoperative sentinel node (SN) detection in patients with initial cervix cancer.
  
  
  METHODS
  Lymphoscintigraphy and intraoperative SN detection was performed in 17 patients with initial cervix cancer who we going to have a radical laparoscopic hysterectomy and pelvic lymphadenectomy. Conization was performed in 4/17. The day before surgery, an injection of 111 MBq 99mtechnetium nanocolloid around the primary tumour and a subsequent lymphoscintigraphy were carried out. Blue dye was injected at the same location intraoperatively. A laparoscopic gamma probe was used to identify SNs.
  
  
  RESULTS
  SNs were successfully localized using a combination of radiocolloid and blue dye in 16/17 patients (detection rate 94 %). The detection rate only using blue dye technique decreases to 71 % (12/17) and it reaches an 82 % (14/17) if we avoid the blue dye injection. In 3 cases, there was no migration in lymphoscintigraphy and in one of the three SN could not be detected. Thirty-three SNs were identified (1.9 nodes/patient). The most frequent location was left external iliac nodal group (13 nodes: 39 %). SNs were identified in regions that are not included in usual lymphadenectomy: right parametrium (2 sentinel nodes, one of them in the retrouterine region), and interiliac (2 SNs). In all four patients with previous conization SNs were identified (detection rate 100 %).
  
  
  CONCLUSIONS
  The rate of SN detection combining lymphoscintigraphy with gamma probe and blue dye is 82 %. The use of blue dye allows increasing this rate to 94 % in those cases which migration was not seen or when the SN is placed near the injection site. The SN technique offers the possibility to find SNs in regions not included in usual lymphadenectomy.
authors.affiliation: Servicio de Medicina Nuclear, CDIC, Hospital Clínic de Barcelona.
authors.forename: P
authors.initials: P
authors.lastname: Paredes
authors.forename: S
authors.initials: S
authors.lastname: Vidal-Sicart
authors.forename: S
authors.initials: S
authors.lastname: García
authors.forename: J
authors.initials: J
authors.lastname: Pahisa
authors.forename: A
authors.initials: A
authors.lastname: Torné
authors.forename: J
authors.initials: J
authors.lastname: Ordi
authors.forename: S
authors.initials: S
authors.lastname: Fuertes
authors.forename: M
authors.initials: M
authors.lastname: Ortega
authors.forename: F
authors.initials: F
authors.lastname: Pons
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D009367:Neoplasm Staging; D021701:Sentinel Lymph Node Biopsy; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*