title: Differential expression of manganese containing superoxide dismutase in patients with breast cancer in Taiwan.
abstract: This study used Western blot analysis to measure the expression of superoxide dismutases (Mn-SOD and Cu/Zn-SOD) in breast cancer tissues from 57 patients. Mn-SOD expression in the breast cancer tissues averaged 1.5-fold higher than in the adjacent tumor-free tissues (p <0.05). There was no significant difference in Cu/Zn-SOD expression between neoplastic and tumor-free breast tissues. This study shows a significant increase of Mn-SOD expression in breast cancer tissues. The authors speculate that up-regulation of Mn-SOD expression induced by oxidative stress or local inflammation may contribute a selective growth advantage to tumor cells compared to their normal counterparts.
authors.affiliation: Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
authors.forename: Tze-Kiong
authors.initials: TK
authors.lastname: Er
authors.forename: Ming-Feng
authors.initials: MF
authors.lastname: Hou
authors.forename: Eing-Mei
authors.initials: EM
authors.lastname: Tsa
authors.forename: Jau-Nan
authors.initials: JN
authors.lastname: Lee
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Tsai
mesh_terms: D015153:Blotting, Western; D001943:Breast Neoplasms / Q000201:enzymology*; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology; D005260:Female; D006801:Humans; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*; D013624:Taiwan
chemical_list: D013482:Superoxide Dismutase