Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus.
A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3-carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus.
González
Isabel C
IC
Elanco Animal Health Research and Development, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140-0708, USA. gonzalez_isabel_c@lilly.com
Davis
Leon N
LN
Smith
Charles K
CK
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D006189:Haemonchus / Q000187:drug effects*; D007700:Kinetics; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000871:Anthelmintics; D013876:Thiophenes