title: Simultaneous development of bilateral retrobulbar and intradural spinal masses following donor lymphocyte infusions for acute lymphoblastic leukemia relapsing after bone marrow transplantation.
abstract: The authors describe a 6-year-old boy with acute lymphoblastic leukemia in relapse after bone marrow transplantation. Complete remission was obtained after reinduction chemotherapy followed by donor lymphocyte infusions. Ten months later, right-sided proptosis and exotropia developed, with back pain and leg paralysis. Computed tomography revealed bilateral orbital masses. Magnetic resonance imaging demonstrated abnormal signal intensity in the T4-6 vertebral bodies and an intradural mass on the left posterior side of the spinal canal. Although bone marrow aspiration was negative, orbital mass biopsies revealed CD10-positive lymphoblasts. Chimerism analysis of bone marrow and peripheral blood showed full donor alleles. Local radiotherapy and chemotherapy resulted in neurologic improvement.
authors.affiliation: Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Taoyuan, Taiwan. jaing001@cgmh.org.tw
authors.forename: Tang-Her
authors.initials: TH
authors.lastname: Jaing
authors.forename: Huei-Shyong
authors.initials: HS
authors.lastname: Wang
authors.forename: Chen-Kan
authors.initials: CK
authors.lastname: Tseng
authors.forename: Chuen
authors.initials: C
authors.lastname: Hsueh
authors.forename: Chao-Jan
authors.initials: CJ
authors.lastname: Wang
authors.forename: Yueh-Ju
authors.initials: YJ
authors.lastname: Tsai
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D016026:Bone Marrow Transplantation; D002648:Child; D006801:Humans; D017710:Lymphocyte Transfusion; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009918:Orbital Neoplasms / Q000473:pathology* / Q000503:physiopathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D013125:Spinal Neoplasms / Q000473:pathology* / Q000503:physiopathology