title: Effects of isothiocyanates on tumor necrosis factor-alpha production by J774A.1 (BALB/c macrophage) cells.
abstract: The effects of isothiocyanates (ITCs) on tumor necrosis factor-alpha (TNF-alpha) production by the J774A.1 mouse macrophage cell line stimulated with lipopolysaccharide (LPS) were examined. Some individual ITCs examined showed a priming effect, which was expressed as pre-activation, but also inhibited the production of TNF-alpha with concomitant stimulation by LPS, as a triggering stimulant of TNF production. These results suggest that ITCs exert opposing activities that can enhance or inhibit the host defense system.
authors.affiliation: Hiroshima Prefectural Food Technology Research Center, Hiroshima, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Ohta
authors.forename: Kohji
authors.initials: K
authors.lastname: Yamaki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Osawa
authors.forename: Shunro
authors.initials: S
authors.lastname: Kawakishi
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004336:Drug Antagonism; D017879:Isothiocyanates / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis*
chemical_list: D017879:Isothiocyanates; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha