Metamizole sodium-induced severe aplastic anemia and its recovery with a short-course steroid therapy.
The authors treated a girl with severe aplastic anemia that developed following urinary tract infection. She was referred to our hospital for bone marrow transplantation. The detailed medical history of the patient revealed iatrogenic metamizole sodium overdose that was given during her infection. She responded to a 3-day, high-dose methylprednisolone therapy and consequent conventional dose steroid. The authors observed at first partial and subsequently complete remission of all the hematologic parameters of the patient within 30 days and 4 months, respectively. This case suggests that the history of drug use should be questioned carefully in the patients with aplastic features. Steroid treatment may be an appropriate alternative therapy for aplastic anemia if associated drug use is detected in the medical history.
Yetgin
Sevgi
S
Section of Pediatric Hematology, Ihsan Dogramaci Children's Hospital, Hacettepe University, Ankara, Turkey. yetgins@superonline.com
Ozyürek
Emel
E
Aslan
Deniz
D
Cetin
Mualla
M
D000293:Adolescent; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000188:drug therapy*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D004177:Dipyrone / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D013256:Steroids; D004177:Dipyrone; D008775:Methylprednisolone