[Progression of tocotrienols].
Tocotrienols is an isoform of tocopherols. Tocotrienols consists of a chromanol nucleus and a lipophilic isoprenoid chain. Tocotrienols were found in high concentrations in palm oil and rice bran. Its discovery was mainly antioxidant and resistant to lipid peroxidation. Tocotrienols influenced cholesterol synthesis by directly regulated activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductae (HMG CoA reductase) and decreased cholesterol. Important novel antiproliferative and neuroprotective effects have found. Molecular structure and biological function of tocotrienols were reviewed in this paper.
Sun
Wenguang
W
First Clinic College of Harbin Medical University, Harbin 150001, China.
Yan
Yageng
Y
Dong
Fengli
F
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology; D024508:Tocotrienols / Q000737:chemistry / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D000975:Antioxidants; D018696:Neuroprotective Agents; D024508:Tocotrienols