Evaluation of anti-ulcerogenic and ulcer-healing properties of Ocimum sanctum Linn.
Ocimum sanctum (OS) is known to possess various therapeutic properties. We evaluated its anti-ulcerogenic activity in cold restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models in Sprague-Dawley rats, histamine-induced duodenal (HST) ulcer in guinea pigs, and ulcer-healing activity, in acetic acid-induced (AC) chronic ulcer model. We found that OS, decreased the incidence of ulcers and also enhanced the healing of ulcers. OS at a dose of 100 mg/kg was found to be effective in CRU (65.07%), ASP (63.49%), AL (53.87%), PL (62.06%), and HST (61.76%) induced ulcer models and significantly reduced free, total acidity and peptic activity by 72.58, 58.63, 57.6%, respectively, and increased mucin secretion by 34.61%. Additionally, OS completely healed the ulcers within 20 days of treatment in AC. We observed that anti-ulcer effect of OS may be due to its cytoprotective effect rather than antisecretory activity. Conclusively, OS was found to possess potent anti-ulcerogenic as well as ulcer-healing properties and could act as a potent therapeutic agent against peptic ulcer disease.
Dharmani
Poonam
P
Division of Pharmacology, Central Drug Research Institute, P.O. Box 173, Lucknow 226001, UP, India.
Kuchibhotla
Vijay Kumar
VK
Maurya
Rakesh
R
Srivastava
Sudhir
S
Sharma
Sharad
S
Palit
Gautam
G
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D000431:Ethanol; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D008297:Male; D031339:Ocimum; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D006632:Histamine; D001241:Aspirin