A noninflammatory pathway for pregnancy loss: innate immune activation?
Although the mechanisms of immune-mediated pregnancy loss are unknown, investigations are currently focused on mediators of immune activation and tissue injury at the maternal-fetal interface. A new study, however, demonstrates that systemic inflammatory mediators can induce pregnancy failure in a different way, by inhibiting ovarian hormone production, and identifies links between the immune and reproductive endocrine systems.
Salmon
Jane E
JE
Department of Medicine, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, New York 10021, USA. salmonj@hss.edu
D000022:Abortion, Spontaneous / Q000209:etiology* / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D007109:Immunity; D007249:Inflammation; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011247:Pregnancy