Imaging and quantification of calcified corneal lesions with optical coherence tomography.
OBJECTIVE
The purpose of this study was to image and quantify calcified corneal lesions with optical coherence tomography (OCT) and to evaluate this diagnostic method to assess this corneal disease.


METHODS
In a clinical study 15 eyes of 14 patients with calcified corneal lesions in the anterior portions of the cornea were assessed with slit-lamp biomicroscopy and slit-lamp-adapted OCT. The qualitative and quantitative optical changes were compared with the clinical findings.


RESULTS
In corneal OCT all calcified lesions revealed marked hyperreflective changes that correlated well with macroscopic findings. Dense calcified lesions resulted in partial or complete shadowing of the posterior corneal structures. The thickness values for the hyperreflective calcified lesions ranged from 27 to 344 microm.


CONCLUSIONS
Noncontact slit-lamp-adapted OCT may be of value in assessing calcified corneal lesions. Corneal OCT could also be used to precisely measure the depth of these corneal processes and evaluate treatment modalities.
Wirbelauer
Christopher
C
Klinik für Augenheilkunde, Vivantes Klinikum Neukölln, Rudower Str. 48, D-12351 Berlin, Germany. knk.augen@vivantes.de
Pham
Duy Thoai
DT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000175:diagnosis*; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000175:diagnosis*; D003941:Diagnostic Techniques, Ophthalmological; D006801:Humans; D008875:Middle Aged; D041623:Tomography, Optical Coherence / Q000379:methods*