title: Impacted morselized cancellous bone: mechanical effects of defatting and augmentation with fine hydroxyapatite particles.
abstract: Geotechnical engineering testing techniques were used to study the mechanical properties of morselized cancellous bone (MCB) and the effects of defatting and augmentation with fine hydroxyapatite (HA) particles. Bovine and human cancellous bone was morselized, rinsed, and manually squeezed to remove excess fluid, producing a standard surgical MCB sample that was also used as a control. Some of the MCB was defatted with heat and detergent and mixed with HA particles in ratios ranging from 0% to 100% HA. Compaction tests were used to determine the effects of moisture content and the amount of MCB that can be packed into a confined space. One-dimensional consolidation tests were used to determine the uniaxial strain behavior, confined modulus, and steady-state creep rate. The compaction tests demonstrated that defatting and adding HA particles significantly increased density. The one-dimensional consolidation tests showed that strain was decreased, modulus was increased and the creep rate was decreased by defatting and adding HA.
authors.affiliation: Department of Orthopaedic Surgery, University of Louisville, Louisville, KY 40202, USA. mike.voor@louisville.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Voor
authors.forename: J E
authors.initials: JE
authors.lastname: White
authors.forename: J E
authors.initials: JE
authors.lastname: Grieshaber
authors.forename: A L
authors.initials: AL
authors.lastname: Malkani
authors.forename: C R
authors.initials: CR
authors.lastname: Ullrich
mesh_terms: D000818:Animals; D001834:Body Water / Q000737:chemistry / Q000378:metabolism; D018786:Bone Substitutes / Q000737:chemistry / Q000592:standards / Q000627:therapeutic use*; D002417:Cattle; D017886:Durapatite / Q000737:chemistry / Q000592:standards / Q000627:therapeutic use*; D005223:Fats / Q000737:chemistry; D005269:Femur / Q000378:metabolism; D006801:Humans; D008422:Materials Testing; D010316:Particle Size; D019736:Prostheses and Implants; D013314:Stress, Mechanical; D013977:Tibia / Q000378:metabolism; D019737:Transplants
chemical_list: D018786:Bone Substitutes; D005223:Fats; D017886:Durapatite