title: Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity.
abstract: OBJECTIVE
  Adiponectin is negatively associated with leptin, insulin and obesity in children and adults. Whereas increases in fetal insulin and leptin are associated with increased weight and adiposity at birth, the role of adiponectin in fetal growth has not yet been determined. The aims of this study were to examine the relationships between adiponectin and insulin, leptin, weight and adiposity at birth in healthy term infants.
  
  
  METHODS
  Anthropometric parameters including weight, length, circumferences and skinfold thickness were measured, and plasma lipid profiles, insulin, leptin and adiponectin concentrations in cord blood samples from 226 singleton infants born at term after uncomplicated pregnancies were assayed.
  
  
  RESULTS
  Cord plasma adiponectin, leptin and insulin levels correlated significantly and positively with birthweight (P = 0.001, P < 0.001, P < 0.001, respectively) and the sum of skinfold thicknesses (P < 0.001, P < 0.001, P < 0.001, respectively). Mean cord plasma adiponectin and leptin levels, but not insulin level, were significantly higher in large-for-gestational-age (LGA) infants compared with appropriate-for-gestational-age (AGA) infants. Cord plasma leptin concentration, but not adiponectin concentration, was significantly higher in female infants than in male infants (P = 0.003 and P = 0.94, respectively). Cord plasma adiponectin concentration correlated positively with leptin level (P = 0.007) but not with insulin level (P = 0.78).
  
  
  CONCLUSIONS
  High adiponectin levels are present in the cord blood. Cord plasma adiponectin and leptin levels are positively correlated with birthweight and adiposity. This suggests that adiponectin may be involved in regulating fetal growth.
authors.affiliation: Department of Food Science, and Institute of Biotechnology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan.
authors.forename: Po-Jung
authors.initials: PJ
authors.lastname: Tsai
authors.forename: Chun-Hsien
authors.initials: CH
authors.lastname: Yu
authors.forename: Shih-Penn
authors.initials: SP
authors.lastname: Hsu
authors.forename: Yu-Hsiang
authors.initials: YH
authors.lastname: Lee
authors.forename: Chuen-Hua
authors.initials: CH
authors.lastname: Chiou
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hsu
authors.forename: Su-Chen
authors.initials: SC
authors.lastname: Ho
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Chu
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000033:anatomy & histology*; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D005314:Embryonic and Fetal Development / Q000502:physiology; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005783:Gender Identity; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007328:Insulin / Q000097:blood; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D011506:Proteins / Q000032:analysis*; D012885:Skinfold Thickness
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins