title: FR901512, a novel HMG-CoA reductase inhibitor produced by an agonomycetous fungus No. 14919. II. Taxonomy of the producing organism, fermentation, isolation and physico-chemical properties.
abstract: Novel compounds FR901512 and FR901516 were isolated from the fermentation broth of agonomycete strain No. 14919. FR901512 and FR901516 possess unique tetralin ring in their structure. These compounds were potent inhibitors of the cholesterol synthesis in human hepatoma cell line Hep G2. FR901512 shows strong 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitory activity with an IC50 value of 0.95 nM.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. hidetaka_hatori@po.fujisawa.co.jp
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Hatori
authors.forename: Bunji
authors.initials: B
authors.lastname: Sato
authors.forename: Ikuko
authors.initials: I
authors.lastname: Sato
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Takase
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Ueda
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
mesh_terms: D045744:Cell Line, Tumor; D002784:Cholesterol / Q000378:metabolism; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004952:Esters; C487955:FR901512; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013764:Tetrahydronaphthalenes; D002784:Cholesterol