title: Potential eye irritation of some "biodegradable" liquid scintillation cocktails determined in vitro.
abstract: The potential eye irritation of a range of liquid scintillation cocktails has been evaluated by an in vitro method using the chorioallantoic membrane as an alternative to the Draize rabbit test. All the cocktails studied are potentially moderately to strongly irritant. The only slightly irritant product was Solventgreen, which is a solvent used in some of the cocktails. There is a correlation between the concentration of the cocktail and the potential eye irritation induced. Manufacturers of chemicals including liquid scintillation cocktails should accept responsibility for disclosing data about the composition and toxicity of their products with regard to waste disposal and safety of laboratory staff.
authors.affiliation: Departament de Fisiologia-Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII s/n, E-08028 Barcelona, Spain. mpvinardelmh@ub.edu
authors.forename: M P
authors.initials: MP
authors.lastname: Vinardell
authors.forename: V
authors.initials: V
authors.lastname: Rimbau
authors.forename: M
authors.initials: M
authors.lastname: Mitjans
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D002642:Chick Embryo; D002824:Chorionic Villi / Q000187:drug effects; D004338:Drug Combinations; D005128:Eye Diseases / Q000139:chemically induced*; D007509:Irritants; D008566:Membranes / Q000187:drug effects; D019275:Radiopharmaceuticals / Q000633:toxicity*; D012997:Solvents / Q000633:toxicity
chemical_list: D004338:Drug Combinations; D007509:Irritants; D019275:Radiopharmaceuticals; D012997:Solvents